{"text_format":"3","workbook":"xlsx","n_sheets":13,"sheets":["Table S1","Table S2","Table S3","Table S4","AUC","SE","RI","MXE","A5SS","A3SS","Proteomics","AS_DEP","AS_DEP_KEGG"],"bounds":{"halvings":2},"cells_cut":43,"read":"whole","date_system":"1900"}

{"sheet":"Table S1","index":0,"n_rows":8,"n_cols":4,"rows_kept":8}
[{"$nulls":3},"The sequences of shRNA/sgRNA"]
["shRBM39#1","5-CCGGGCTTCGAGTGCTAGTTCATTTCTCGAGAAATGAACTAGCACTCGAAGCTTTTTGAATT-3"]
["shRBM39#2","5-CCGGGGAAGCGAAGTAGAGACAGAGCTCGAGCTCTGTCTCTACTTCGCTTCCTTTTTGAATT-3"]
["shRBM39#3","5-CCGGCCAAGGGATATGGATTTATTACTCGAGTAATAAATCCATATCCCTTGGTTTTTGAATT-3"]
["shZMYND8#1","5-CCGGGGACAGATGCATTCCAGAAGCCTCGAGGCTTCTGGAATGCATCTGTCCTTTTTGAATT-3"]
["shZMYND8#2","5-CCGGGCAGCATCCTGAATCTTAACCCTCGAGGGTTAAGATTCAGGATGCTGCTTTTTGAATT-3"]
["shZMYND8#3","5-CCGGGCTGATGTCGCCGCTGATATTCTCGAGAATATCAGCGGCGACATCAGCTTTTTGAATT-3"]
["sgDCAF15","caccgTTCCGCTCCGATTTCGAGCT"]

{"sheet":"Table S2","index":1,"n_rows":9,"n_cols":3,"rows_kept":9}
[null,"the sequences of PCR primers (5'-3')","the sequences of qPCR primers (5'-3')"]
["EZH2 forward","AGAGGAAACACCGGTTGTGG","—"]
["EZH2 reverse","CAGCGGCTCCACAAGTAAGA","—"]
["ZMYND8 forward","CCGCAGGACACATCAACAAG","GGGTTTATCACGCTAAGTGTCTG"]
["ZMYND8 reverse","GTCAGGGTGCTGTTCCAATG"," GGCTTTACTCTGGGTCTCGATG"]
["RBM39 forward","—","AAAAGCCGTGAAAGAAAGCGA"]
["RBM39 reverse","—","GCGGCCTCTAAATCTTCGATCT"]
["GAPDH forward","AAGCCTGCCGGTGACTAAC","GTTAGGAAAGCCTGCCGGT"]
["GAPDH reverse","TGACGAACATGGGGGCATC","ATGGTTCACACCCATGACGAA"]

{"sheet":"Table S3","index":2,"n_rows":10,"n_cols":2,"rows_kept":10}
["Protein","Information"]
["RBM39","Proteintech, 21339-1-AP, China"]
["ZMYND8","Bethyl, A302-090A, USA"]
["EZH2","Proteintech, 21800-1-AP, China"]
["PARP","Cell Signaling Technology, 9542, USA"]
["CDK4","Cell Signaling Technology, 12790, USA"]
["c-MYC","Cell Signaling Technology, 9402, USA"]
["GAPDH","Millipore, MA3374, USA"]
["Horseradish Peroxidase-conjugated AffiniPure Goat Anti-Rabbit IgG （H+L）","Jackson, 111-035-003，USA"]
["Ki67","Servicebio, GB12114, China"]

{"sheet":"Table S4","index":3,"n_rows":25383,"n_cols":13,"rows_kept":1125,"cut":true,"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
["gene_id","gene_name","Ctrl_1_count","Ctrl_2_count","Indisulam_1_count","Indisulam_2_count","Ctrl_1_FPKM","Ctrl_2_PFKM","Indisulam_1_FPKM","Indisulam_2_FPKM","log2FoldChange","Pvalue","FDR"]
["ENSG00000198673.10","FAM19A2",8979,8509,1286,1404,52.031761,51.452061,9.007653,9.424492,-2.74795546474326,0,0]
["ENSG00000002549.12","LAP3",14029,12358,2173,2290,53.081356,49.342083,9.941399,9.977858,-2.60950257506217,0,0]
["ENSG00000082212.12","ME2",9866,9066,1497,1719,10.779269,12.184938,3.403611,3.484208,-2.60495555908747,0,0]
["ENSG00000175567.8","UCP2",15395,15575,2877,3006,58.623997,61.760857,15.272813,15.363102,-2.44399919685803,0,0]
["ENSG00000176890.15","TYMS",34284,32018,6621,6773,151.224106,144.850845,35.491257,33.195728,-2.35369385396436,0,0]
["ENSG00000278259.4","MYO19",10768,10518,2255,2266,21.668167,22.732351,6.118916,5.553539,-2.28190987193929,0,0]
["ENSG00000164062.12","APEH",17349,17513,3777,3711,44.350075,47.142338,13.467039,11.523752,-2.26587354273833,0,0]
["ENSG00000169299.13","PGM2",11748,11070,2471,2515,26.934381,25.775248,6.932814,6.226526,-2.24055829745684,0,0]
["ENSG00000094804.10","CDC6",15812,14797,3281,3438,36.227329,35.68869,8.48903,7.978634,-2.23424563362119,0,0]
["ENSG00000174780.16","SRP72",30333,28107,6681,6594,64.264099,66.409607,21.021307,18.815071,-2.1838244965246,0,0]
["ENSG00000132182.11","NUP210",35070,34811,8269,8383,36.886814,37.732967,10.343289,9.723853,-2.11623173908369,0,0]
["ENSG00000127022.14","CANX",138887,126674,31574,31922,245.246048,224.78598,68.331848,63.529903,-2.10992746050173,0,0]
["ENSG00000115904.12","SOS1",100602,94834,24693,24440,99.725441,96.227425,30.879992,29.362633,-2.03774502155665,0,0]
["ENSG00000124571.17","XPO5",20865,19818,5672,5765,31.861937,30.643339,12.371904,11.713604,-1.87711861089742,0,0]
["ENSG00000272398.5","CD24",47789,44207,12892,13401,142.243729,137.399155,48.96439,47.626354,-1.85319208103483,0,0]
["ENSG00000163399.15","ATP1A1",40304,39790,11443,11811,82.940208,84.134415,28.788202,27.490999,-1.83141806210442,0,0]
["ENSG00000112972.14","HMGCS1",36238,33669,10656,11282,78.642227,74.992706,29.235846,28.069117,-1.71865166574004,0,0]
["ENSG00000182308.6","DCAF4L1",477,434,6026,6298,0.697514,0.642817,10.373751,10.181631,3.71137851786648,0,0]
["ENSG00000177606.6","JUN",198,234,5553,5952,0.388282,0.470019,12.971883,12.966956,4.68650533995437,0,0]
["ENSG00000103876.12","FAH",14641,14174,3554,3823,67.53804,65.60881,20.336248,20.264681,-2.01318774919043,{"v":2.03849530443832E-303,"d":"2.04E-303"},{"v":2.53680548160826e-300,"d":"2.54E-300"}]
["ENSG00000068796.16","KIF2A",13855,13007,3357,3436,39.731487,39.201771,10.206308,8.984552,-2.02978920311478,{"v":3.0449485186514e-296,"d":"3.04E-296"},{"v":3.60884398479594e-293,"d":"3.61E-293"}]
["ENSG00000115232.13","ITGA4",103461,95910,35893,36960,211.651947,206.226837,95.903084,91.819748,-1.49856686049272,{"v":1.58248069765446E-293,"d":"1.58E-293"},{"v":1.79028918563282E-290,"d":"1.79E-290"}]
["ENSG00000134363.11","FST",7191,6545,952,1085,21.74954,20.502293,3.305995,3.614086,-2.80060092128902,{"v":5.10981469675796e-293,"d":"5.11E-293"},{"v":5.52948599946125e-290,"d":"5.53E-290"}]
["ENSG00000141076.17","UTP4",11308,11188,2580,2715,38.227222,38.827389,11.232618,11.043012,-2.13446545792863,{"v":7.27501987855656e-289,"d":"7.28E-289"},{"v":7.54449873989143e-286,"d":"7.54E-286"}]
["ENSG00000131747.14","TOP2A",63117,57579,19523,19454,81.521973,76.462875,29.807154,28.439278,-1.67609496825506,{"v":1.0502132010585E-284,"d":"1.05E-284"},{"v":1.0455502544458e-281,"d":"1.05E-281"}]
["ENSG00000244462.7","RBM12",18191,16602,4762,5029,24.33289,23.311085,8.026687,7.811079,-1.87560577578297,{"v":2.03809304628589E-275,"d":"2.04E-275"},{"v":1.95100376265422E-272,"d":"1.95E-272"}]
["ENSG00000149534.8","MS4A2",701,608,5112,5452,1.927575,1.859885,18.29022,17.817112,2.96639003575721,{"v":1.65414886043144e-264,"d":"1.65E-264"},{"v":1.52481892545474E-261,"d":"1.52E-261"}]
["ENSG00000197451.11","HNRNPAB",43983,42605,10457,12413,185.416794,186.290268,52.711212,58.203239,-1.96978498102636,{"v":2.01285020906983E-264,"d":"2.01E-264"},{"v":1.78920817334068E-261,"d":"1.79E-261"}]
["ENSG00000130544.11","ZNF557",1238,1216,6989,7047,1.697523,1.679646,10.547376,9.92317,2.46927473491919,{"v":2.99293594125447e-260,"d":"2.99E-260"},{"v":2.56866147040974e-257,"d":"2.57E-257"}]
["ENSG00000085465.12","OVGP1",187,172,3436,3269,0.543946,0.578524,13.528778,12.662701,4.1779865859351,{"v":1.33525100286024e-259,"d":"1.34E-259"},{"v":1.10776874033961E-256,"d":"1.11E-256"}]
["ENSG00000136628.17","EPRS",49148,43807,13708,13235,72.551018,66.405205,24.222876,21.926416,-1.83118217054836,{"v":3.297000419036e-256,"d":"3.30E-256"},{"v":2.647065917077E-253,"d":"2.65E-253"}]
["ENSG00000198589.11","LRBA",12608,11869,3334,3468,9.643288,9.939929,3.498573,4.015913,-1.89399741892955,{"v":4.16806037597586e-254,"d":"4.17E-254"},{"v":3.24183920930198e-251,"d":"3.24E-251"}]
["ENSG00000037474.14","NSUN2",32626,30530,11087,11342,79.446991,77.269928,37.176601,36.843056,-1.53979665989119,{"v":1.50385464940191e-252,"d":"1.50E-252"},{"v":1.13422540512012e-249,"d":"1.13E-249"}]
["ENSG00000176393.10","RNPEP",10725,10469,2715,2769,34.68998,35.520824,11.523447,10.783201,-1.99724131086565,{"v":1.70458882416832e-251,"d":"1.70E-251"},{"v":1.24780915425663E-248,"d":"1.25E-248"}]
["ENSG00000093009.9","CDC45",10114,9915,2011,1829,41.986492,41.586391,9.033404,8.424757,-2.42834558684501,{"v":7.50249532444998e-251,"d":"7.50E-251"},{"v":5.33513160372102e-248,"d":"5.34E-248"}]
["ENSG00000088832.16","FKBP1A",39677,37479,13975,14100,214.742035,214.743286,108.837967,107.42572,-1.50466116019471,{"v":3.35107226511332e-249,"d":"3.35E-249"},{"v":2.31680104462237e-246,"d":"2.32E-246"}]
["ENSG00000112118.18","MCM3",64346,61668,24555,24993,157.448074,155.944061,70.219444,66.774315,-1.39320097138583,{"v":7.25840532298984e-248,"d":"7.26E-248"},{"v":4.88255270497011e-245,"d":"4.88E-245"}]
["ENSG00000109586.11","GALNT7",12195,10844,2762,2762,22.654673,20.835167,6.293099,5.808942,-2.10549514333765,{"v":3.64433287762543e-244,"d":"3.64E-244"},{"v":2.38694213134788e-241,"d":"2.39E-241"}]
["ENSG00000023228.13","NDUFS1",15843,15050,4730,4820,11.385906,12.326762,3.972939,3.90196,-1.74015299868045,{"v":6.06813248298695e-244,"d":"6.07E-244"},{"v":3.8725576761298e-241,"d":"3.87E-241"}]
["ENSG00000278540.4","ACACA",12555,12249,3255,3136,10.587815,10.45025,3.448282,3.221541,-2.00254437921653,{"v":2.15612672967737e-239,"d":"2.16E-239"},{"v":1.3415959543735e-236,"d":"1.34E-236"}]
["ENSG00000116016.13","EPAS1",11084,10734,2641,2960,16.08317,16.030298,4.720325,4.846235,-2.00978746024279,{"v":1.01882263271907E-238,"d":"1.02E-238"},{"v":6.18475036725486e-236,"d":"6.18E-236"}]
["ENSG00000138095.18","LRPPRC",58452,54832,21193,21024,70.601868,68.437233,30.388887,27.856043,-1.46982678491921,{"v":6.60789693950626e-235,"d":"6.61E-235"},{"v":3.91580826017551e-232,"d":"3.92E-232"}]
["ENSG00000099194.5","SCD",63869,60057,24816,25645,84.602196,82.026619,39.407001,37.752682,-1.34269530493499,{"v":9.4477974972056e-235,"d":"9.45E-235"},{"v":5.46851702111512E-232,"d":"5.47E-232"}]
["ENSG00000111684.10","LPCAT3",5532,5245,941,1027,11.872554,11.958752,2.512778,2.284027,-2.5004237728885,{"v":1.14144639483298E-228,"d":"1.14E-228"},{"v":6.4566953002268e-226,"d":"6.46E-226"}]
["ENSG00000128683.13","GAD1",7301,7336,22426,24209,29.834925,24.547268,108.086624,104.90535,1.62368075398598,{"v":1.89261548778012E-227,"d":"1.89E-227"},{"v":1.04678459723021E-224,"d":"1.05E-224"}]
["ENSG00000077380.15","DYNC1I2",8278,7670,1890,1921,26.358946,25.173264,6.422248,6.962838,-2.11121406310967,{"v":3.36673102893482E-227,"d":"3.37E-227"},{"v":1.82162105606867e-224,"d":"1.82E-224"}]
["ENSG00000120437.8","ACAT2",14388,13071,3794,4134,31.291397,30.059429,9.54289,9.792933,-1.83895600823339,{"v":1.86487389819211e-226,"d":"1.86E-226"},{"v":9.87549924512838e-224,"d":"9.88E-224"}]
["ENSG00000198911.11","SREBF2",27711,28052,9477,10017,41.414734,44.264149,18.504869,18.295818,-1.56422131140803,{"v":1.1078139447148E-224,"d":"1.11E-224"},{"v":5.74424609791807e-222,"d":"5.74E-222"}]
["ENSG00000168710.17","AHCYL1",15544,14588,4685,5027,28.021833,27.046974,9.898739,10.010241,-1.68044174803103,{"v":2.3686354744566E-224,"d":"2.37E-224"},{"v":1.20312180252552e-221,"d":"1.20E-221"}]
["ENSG00000132646.10","PCNA",53634,50537,21024,22105,288.222778,277.835632,132.389725,128.728271,-1.31898390820336,{"v":9.12718736386653e-223,"d":"9.13E-223"},{"v":4.54333132598548e-220,"d":"4.54E-220"}]
["ENSG00000059573.8","ALDH18A1",15025,14662,4764,4872,33.164574,33.245392,12.776185,11.771185,-1.67022411923547,{"v":7.60820639280957e-221,"d":"7.61E-221"},{"v":3.71295390020857E-218,"d":"3.71E-218"}]
["ENSG00000149428.18","HYOU1",50112,48514,19914,20339,89.233818,90.930779,44.45504,42.42968,-1.3396014587231,{"v":2.93965825574393e-220,"d":"2.94E-220"},{"v":1.4070221986002e-217,"d":"1.41E-217"}]
["ENSG00000073578.16","SDHA",16039,15610,4757,5276,54.698868,54.166542,20.363064,21.047598,-1.70541803052704,{"v":2.79459193847305e-217,"d":"2.79E-217"},{"v":1.3123509199369e-214,"d":"1.31E-214"}]
["ENSG00000100983.10","GSS",7689,8138,1658,1678,29.695393,32.592312,7.175422,7.345474,-2.29420681393438,{"v":1.99743529259098e-215,"d":"2.00E-215"},{"v":9.20632722172167e-213,"d":"9.21E-213"}]
["ENSG00000004700.15","RECQL",11599,10427,3020,3162,24.064846,21.723696,7.1584,6.937225,-1.879058175161,{"v":6.98168319764825e-212,"d":"6.98E-212"},{"v":3.15940205647759e-209,"d":"3.16E-209"}]
["ENSG00000170515.13","PA2G4",37404,33764,12922,13131,176.45874,163.0439,73.274391,67.329353,-1.49535108088268,{"v":6.63289362685598E-211,"d":"6.63E-211"},{"v":2.94796588355033e-208,"d":"2.95E-208"}]
["ENSG00000075826.16","SEC31B",4476,4341,14994,14851,10.003595,9.993553,46.910809,43.207584,1.71288313967063,{"v":5.53786282352649E-209,"d":"5.54E-209"},{"v":2.41810294411843e-206,"d":"2.42E-206"}]
["ENSG00000204394.12","VARS",22700,23423,7545,7676,41.464066,43.394356,16.872177,16.001423,-1.64708848678828,{"v":3.50867820371678e-208,"d":"3.51E-208"},{"v":1.50564641055702E-205,"d":"1.51E-205"}]
["ENSG00000179218.13","CALR",216416,203610,92861,98558,863.003662,830.822266,439.454254,435.075531,-1.18063237637712,{"v":1.20816065769381E-207,"d":"1.21E-207"},{"v":5.09659501853242e-205,"d":"5.10E-205"}]
["ENSG00000164163.10","ABCE1",31145,27771,10061,10712,58.685951,53.499687,24.916491,24.895267,-1.5500489516963,{"v":4.60499651640021e-207,"d":"4.60E-207"},{"v":1.91022930494475e-204,"d":"1.91E-204"}]
["ENSG00000166197.16","NOLC1",62322,58139,25313,26190,124.613686,124.606934,60.507454,57.838821,-1.27218967201783,{"v":3.78662330506764e-206,"d":"3.79E-206"},{"v":1.54500438425948e-203,"d":"1.55E-203"}]
["ENSG00000138796.16","HADH",10646,9941,2836,2740,24.82247,27.431744,9.828136,7.402933,-1.92990644074828,{"v":7.41057090583611e-206,"d":"7.41E-206"},{"v":2.97486611734444e-203,"d":"2.97E-203"}]
["ENSG00000232611.1","AL683813.1",330,284,3059,3361,0.739649,0.649904,7.819628,8.247425,3.33951508269729,{"v":2.3444994075699e-205,"d":"2.34E-205"},{"v":9.26226123095354e-203,"d":"9.26E-203"}]
["ENSG00000109861.15","CTSC",29347,27005,10646,10931,97.624687,91.760262,41.187504,39.827644,-1.43101221076101,{"v":2.05090545700695e-203,"d":"2.05E-203"},{"v":7.97577904991343e-201,"d":"7.98E-201"}]
["ENSG00000104738.17","MCM4",67980,66420,29027,30101,130.681915,130.849686,66.853432,63.920933,-1.23172794985874,{"v":1.05469133552525E-200,"d":"1.05E-200"},{"v":4.03849425382891e-198,"d":"4.04E-198"}]
["ENSG00000137193.13","PIM1",29651,29998,11032,11618,81.103592,85.084923,35.930405,35.295803,-1.44486801048603,{"v":2.47674052769456e-198,"d":"2.48E-198"},{"v":9.3399386354227e-196,"d":"9.34E-196"}]
["ENSG00000011260.13","UTP18",10983,10318,3174,3420,42.291557,40.417576,14.863696,14.960979,-1.73874383368897,{"v":3.02192125823051E-198,"d":"3.02E-198"},{"v":1.12257609247909e-195,"d":"1.12E-195"}]
["ENSG00000006744.18","ELAC2",18106,18321,6077,6492,46.203896,47.532669,19.410242,18.796459,-1.58321633848246,{"v":6.56169451512292e-198,"d":"6.56E-198"},{"v":2.40167668804257E-195,"d":"2.40E-195"}]
["ENSG00000125166.12","GOT2",17468,15907,5162,5720,52.184132,48.681568,19.22863,20.197989,-1.66382557459514,{"v":1.09547495858294e-197,"d":"1.10E-197"},{"v":3.9514893107494E-195,"d":"3.95E-195"}]
["ENSG00000163938.16","GNL3",35760,33328,13985,14417,138.053802,131.839661,68.333565,63.653469,-1.32873382049379,{"v":4.79050023714527e-197,"d":"4.79E-197"},{"v":1.70329657717584E-194,"d":"1.70E-194"}]
["ENSG00000044574.7","HSPA5",99116,91480,41232,42979,184.6203,175.266312,91.883026,88.637047,-1.22473416711654,{"v":1.25260098184242e-196,"d":"1.25E-196"},{"v":4.39098392071494e-194,"d":"4.39E-194"}]
["ENSG00000132589.15","FLOT2",23809,23582,8955,9214,70.061821,71.176476,31.128813,30.826052,-1.43033590079345,{"v":3.07389272676648e-196,"d":"3.07E-196"},{"v":1.06258494550682E-193,"d":"1.06E-193"}]
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[311,"ENSG00000172534.13","HCFC1","chrX","-",153964123,153964284,153962221,153962306,153964577,153964726,311,{"v":554555,"d":"554,555"},"0,0",{"v":535444,"d":"535,444"},"1,2",298,149,1,1,"1.0,1.0","0.996,0.991",0.006]
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[318,"ENSG00000089820.15","ARHGAP4","chrX","-",153910170,153910404,153910011,153910085,153910505,153910611,318,{"v":823965,"d":"823,965"},"4,2",{"v":171212,"d":"171,212"},"9,4",298,149,{"v":2.1446229084e-05,"d":"2.14E-05"},1.21598699209275E-4,"0.99,0.996","0.905,0.964",0.058]
[322,"ENSG00000089820.15","ARHGAP4","chrX","-",153910505,153910611,153910170,153910404,153910699,153910834,322,{"v":852978,"d":"852,978"},"0,1",{"v":283322,"d":"283,322"},"2,0",255,149,1,1,"1.0,0.998","0.988,1.0",0.005]
[323,"ENSG00000089820.15","ARHGAP4","chrX","-",153910921,153910999,153910699,153910834,153911128,153911189,323,{"v":684757,"d":"684,757"},"2,2",{"v":225248,"d":"225,248"},"8,8",227,149,{"v":2.01947974954E-5,"d":"2.02E-05"},1.14992948632588E-4,"0.996,0.996","0.949,0.953",0.045]
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[327,"ENSG00000089820.15","ARHGAP4","chrX","-",153911128,153911189,153910921,153910999,153913023,153913051,327,{"v":170219,"d":"170,219"},"0,0","73,83","2,1",210,149,0.434089258059,0.969057302358647,"1.0,1.0","0.963,0.983",0.027]
[328,"ENSG00000089820.15","ARHGAP4","chrX","-",153912699,153912802,153910921,153910999,153913023,153913051,328,{"v":436419,"d":"436,419"},"0,0",{"v":164153,"d":"164,153"},"2,1",252,149,0.730395006968,1,"1.0,1.0","0.98,0.989",0.016]
[329,"ENSG00000089820.15","ARHGAP4","chrX","-",153912699,153912802,153911128,153911189,153913023,153913051,329,{"v":866896,"d":"866,896"},"2,0",{"v":270268,"d":"270,268"},"0,1",252,149,1,1,"0.996,1.0","1.0,0.994",1E-3]
[330,"ENSG00000089820.15","ARHGAP4","chrX","-",153913023,153913051,153912699,153912802,153913408,153913600,330,"68,54","0,0","34,30","0,1",177,149,1,1,"1.0,1.0","1.0,0.962",0.019]
[331,"ENSG00000089820.15","ARHGAP4","chrX","-",153913217,153913302,153913023,153913051,153913408,153913600,331,{"v":832846,"d":"832,846"},"5,0",{"v":243237,"d":"243,237"},"3,11",234,149,0.000214800853185,0.00103354728338678,"0.991,1.0","0.981,0.932",0.039]
[332,"ENSG00000089820.15","ARHGAP4","chrX","-",153913777,153913879,153913209,153913600,153918831,153919053,332,{"v":847894,"d":"847,894"},"2,3",{"v":246301,"d":"246,301"},"29,25",251,149,0,0,"0.996,0.994","0.834,0.877",0.14]
[333,"ENSG00000089820.15","ARHGAP4","chrX","-",153913777,153913879,153913408,153913516,153918831,153919053,333,{"v":408417,"d":"408,417"},"3,3",{"v":105114,"d":"105,114"},"0,0",251,149,0.894296286826,1,"0.988,0.988","1.0,1.0",-0.012]
[335,"ENSG00000089820.15","ARHGAP4","chrX","-",153919566,153919686,153919154,153919283,153920625,153920808,335,"59,84",{"v":421523,"d":"421,523"},"9,17",{"v":154168,"d":"154,168"},269,149,0.00390968907093,0.014809611075013,"0.072,0.082","0.031,0.053",0.035]
[342,"ENSG00000089820.15","ARHGAP4","chrX","-",153921364,153921527,153921096,153921159,153921604,153921809,342,{"v":733726,"d":"733,726"},"0,1",{"v":239262,"d":"239,262"},"0,2",298,149,1,1,"1.0,0.997","1.0,0.985",0.006]
[343,"ENSG00000089820.15","ARHGAP4","chrX","-",153921604,153921809,153921096,153921159,153926135,153926244,343,{"v":273365,"d":"273,365"},"0,0","88,75","1,0",298,149,1,1,"1.0,1.0","0.978,1.0",0.011]
[344,"ENSG00000089820.15","ARHGAP4","chrX","-",153932315,153932431,153932070,153932115,153932538,153932584,344,{"v":29642984,"d":"29,642,984"},"0,0",{"v":19792154,"d":"19,792,154"},"1,0",265,149,1,1,"1.0,1.0","0.999,1.0",0]
[345,"ENSG00000089820.15","ARHGAP4","chrX","-",153932538,153932584,153932070,153932115,153933942,153934001,345,{"v":640553,"d":"640,553"},"0,0",{"v":458384,"d":"458,384"},"4,0",195,149,1,1,"1.0,1.0","0.989,1.0",0.006]
[347,"ENSG00000089820.15","ARHGAP4","chrX","-",153933942,153934001,153932070,153932115,153934376,153934475,347,{"v":319284,"d":"319,284"},"0,0",{"v":273276,"d":"273,276"},"1,0",208,149,1,1,"1.0,1.0","0.995,1.0",2E-3]
[348,"ENSG00000089820.15","ARHGAP4","chrX","-",153933942,153934001,153932538,153932584,153934376,153934475,348,{"v":18641710,"d":"18,641,710"},"0,1",{"v":13351282,"d":"13,351,282"},"20,26",208,149,{"v":1.8169789648e-05,"d":"1.82E-05"},1.04219491159607E-4,"1.0,0.999","0.98,0.972",0.024]
[349,"ENSG00000089820.15","ARHGAP4","chrX","-",153934376,153934475,153933942,153934001,153934883,153934999,349,{"v":20361950,"d":"20,361,950"},"2,3",{"v":15481557,"d":"15,481,557"},"0,0",248,149,1,1,"0.998,0.997","1.0,1.0",-2E-3]
[351,"ENSG00000184343.10","SRPK3","chrX","+",153778599,153778674,153777947,153778471,153778934,153780485,351,"33,34","0,0","53,44","1,0",224,149,1,1,"1.0,1.0","0.972,1.0",0.014]
[352,"ENSG00000184343.10","SRPK3","chrX","+",153778934,153780485,153778599,153778674,153781215,153781346,352,"16,21","0,0","27,12","1,0",298,149,1,1,"1.0,1.0","0.931,1.0",0.034]
[354,"ENSG00000198753.11","PLXNB3","chrX","+",153766872,153767913,153765470,153765580,153768248,153768428,354,"7,8","5,0","36,33","0,0",298,149,1.94242964575E-3,0.00782824086514872,"0.412,1.0","1.0,1.0",-0.294]
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[374,"ENSG00000147383.10","NSDHL","chrX","+",152831633,152831700,152830966,152831117,152846281,152846432,374,"32,21","97,84","4,7","91,80",216,149,{"v":1.37472541872e-06,"d":"1.37E-06"},{"v":9.23139732067417e-06,"d":"9.23E-06"},"0.185,0.147","0.029,0.057",0.123]
[375,"ENSG00000147383.10","NSDHL","chrX","+",152858769,152858916,152850264,152850423,152862595,152862724,375,{"v":739665,"d":"739,665"},"0,1",{"v":359410,"d":"359,410"},"0,0",296,149,1,1,"1.0,0.997","1.0,1.0",-2E-3]
[376,"ENSG00000213401.9","MAGEA12","chrX","+",152735147,152735253,152733778,152733859,152736086,152737106,376,"22,5","13,15","3,13","20,19",255,149,0.181528431484,0.467160674399477,"0.497,0.163","0.081,0.286",0.147]
[382,"ENSG00000011677.12","GABRA3","chrX","-",152189729,152189941,152166233,152168563,152197632,152197785,382,"13,15","1,1","19,16","1,6",298,149,0.131808766849,0.353209901269548,"0.867,0.882","0.905,0.571",0.137]
[383,"ENSG00000011677.12","GABRA3","chrX","-",152189729,152189941,152166233,152168563,152208000,152208144,383,"7,11","0,0","10,10","0,2",298,149,0.694870113227,1,"1.0,1.0","1.0,0.714",0.143]
[384,"ENSG00000011677.12","GABRA3","chrX","-",152197632,152197785,152166233,152168563,152208000,152208144,384,"5,4","0,0","21,14","0,2",298,149,0.756034084685,1,"1.0,1.0","1.0,0.778",0.111]
[385,"ENSG00000011677.12","GABRA3","chrX","-",152197632,152197785,152189729,152189941,152208000,152208144,385,"10,7","0,0","30,14","1,0",298,149,1,1,"1.0,1.0","0.938,1.0",0.031]
[386,"ENSG00000011677.12","GABRA3","chrX","-",152208000,152208144,152166233,152168563,152224762,152224845,386,"4,6","0,0","12,15","5,5",293,149,{"v":1.19382547045e-05,"d":"1.19E-05"},{"v":7.02785317438438e-05,"d":"7.03E-05"},"1.0,1.0","0.55,0.604",0.423]
[390,"ENSG00000029993.14","HMGB3","chrX","+",150987127,150987302,150986050,150986190,150987776,150987877,390,{"v":20021939,"d":"20,021,939"},"0,0",{"v":14871789,"d":"14,871,789"},"1,1",298,149,1,1,"1.0,1.0","0.999,0.999",1E-3]
[392,"ENSG00000102181.20","CD99L2","chrX","-",150776173,150776293,150770303,150770369,150793690,150793756,392,{"v":237193,"d":"237,193"},"0,0",{"v":175150,"d":"175,150"},"0,1",269,149,1,1,"1.0,1.0","1.0,0.988",0.006]
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[57164,"ENSG00000138385.15","SSB","chr2","+",169805997,169806113,169805664,169805839,169806784,169806890,57164,"2,2",{"v":46674099,"d":"46,674,099"},"0,2",{"v":32193239,"d":"32,193,239"},265,149,1,1,"0.0,0.0","0.0,0.0",0]
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[62156,"ENSG00000171365.16","CLCN5","chrX","+",50054439,50054633,50050282,50050413,50069878,50070030,62156,"13,2","0,0","5,4","2,0",298,149,0.516311058458,1,"1.0,1.0","0.556,1.0",0.222]
[62335,"ENSG00000138286.14","FAM149B1","chr10","+",73232938,73233197,73230421,73230525,73234816,73234940,62335,"82,63","1,1","8,0","0,0",298,149,1,1,"0.976,0.969","1.0,NA",-0.028]
[62741,"ENSG00000211460.11","TSN","chr2","+",121763004,121763084,121755659,121755845,121765133,121765218,62741,{"v":670621,"d":"670,621"},"0,0",{"v":481593,"d":"481,593"},"71,90",229,149,0,0,"1.0,1.0","0.815,0.811",0.187]
[62967,"ENSG00000144134.18","RABL2A","chr2","+",113641352,113641450,113635050,113635130,113641780,113641864,62967,"2,3","0,1","9,6","0,0",247,149,1,1,"1.0,0.644","1.0,1.0",-0.178]
[63149,"ENSG00000024526.16","DEPDC1","chr1","-",68481439,68481612,68479143,68479320,68483949,68484090,63149,{"v":505460,"d":"505,460"},"0,0",{"v":356428,"d":"356,428"},"7,5",298,149,0.0144310045185,0.0486953850857886,"1.0,1.0","0.962,0.977",0.03]
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[63832,"ENSG00000138018.17","SELENOI","chr2","+",26364831,26364940,26364301,26364370,26373366,26373506,63832,{"v":226276,"d":"226,276"},"0,0",{"v":138144,"d":"138,144"},"0,1",258,149,1,1,"1.0,1.0","1.0,0.988",0.006]
[64126,"ENSG00000109919.9","MTCH2","chr11","-",47622700,47622776,47617315,47618919,47625673,47625741,64126,{"v":20761841,"d":"20,761,841"},"2,0",{"v":416510,"d":"416,510"},"0,0",225,149,1,1,"0.999,1.0","1.0,1.0",0]
[64354,"ENSG00000204410.14","MSH5","chr6","+",31740453,31740613,31739947,31740220,31741162,31741286,64354,{"v":272268,"d":"272,268"},"3,0",{"v":103121,"d":"103,121"},"9,8",298,149,{"v":1.77264566692e-07,"d":"1.77E-07"},{"v":1.33165365609186E-6,"d":"1.33E-06"},"0.978,1.0","0.851,0.883",0.122]
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[65023,"ENSG00000132676.15","DAP3","chr1","+",155709772,155709824,155689057,155689174,155717005,155717128,65023,{"v":8771165,"d":"8,771,165"},"3,2",{"v":8251036,"d":"8,251,036"},"1,0",201,149,1,1,"0.995,0.998","0.998,1.0",-0.003]
[65444,"ENSG00000106976.20","DNM1","chr9","+",128234815,128234935,128234020,128234107,128239444,128239515,65444,"1,6","65,42","0,0","54,23",269,149,0.0639479886668,0.185829605696563,"0.008,0.073","0.0,0.0",0.04]
[65562,"ENSG00000137200.12","CMTR1","chr6","+",37475320,37475412,37474523,37474646,37476125,37476194,65562,{"v":434402,"d":"434,402"},"0,0",{"v":153200,"d":"153,200"},"0,5",241,149,0.984352871249,1,"1.0,1.0","1.0,0.961",0.02]
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[83086,"ENSG00000059377.16","TBXAS1","chr7","+",139953367,139953456,139936190,139936307,139957633,139957764,83086,"68,95","0,0",{"v":92116,"d":"92,116"},"2,3",238,149,0.254706789206,0.627146078784395,"1.0,1.0","0.966,0.96",0.037]
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[84249,"ENSG00000135838.13","NPL","chr1","+",182803697,182803771,182794349,182794439,182814782,182814858,84249,{"v":138157,"d":"138,157"},"0,0","28,38","0,1",223,149,1,1,"1.0,1.0","1.0,0.962",0.019]
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[85122,"ENSG00000073803.13","MAP3K13","chr3","+",185428496,185429056,185285524,185285643,185437446,185437630,85122,"4,1","0,0","4,3","2,0",298,149,0.461057550646,1,"1.0,1.0","0.5,1.0",0.25]
[85568,"ENSG00000128694.11","OSGEPL1","chr2","-",189755172,189755560,189753915,189754064,189761646,189761660,85568,"0,5","5,0","5,30","1,2",298,149,0.102805345916,0.283336559497601,"0.0,1.0","0.714,0.882",-0.298]
[85855,"ENSG00000269891.2","ARHGAP19-SLIT1","chr10","-",97243967,97244159,97235216,97235315,97246271,97246337,85855,{"v":637602,"d":"637,602"},"5,2",{"v":634568,"d":"634,568"},"23,22",298,149,{"v":1.99553987779e-08,"d":"2.00E-08"},{"v":1.67073729709037e-07,"d":"1.67E-07"},"0.985,0.993","0.932,0.928",0.059]
[86094,"ENSG00000155749.12","ALS2CR12","chr2","-",201346541,201346675,201330735,201330833,201350710,201350782,86094,"0,2","0,0","0,0","1,0",283,149,1,1,"NA,1.0","0.0,NA",1]
[86279,"ENSG00000048028.11","USP28","chr11","-",113815173,113815382,113813754,113813955,113817657,113817837,86279,{"v":409452,"d":"409,452"},"0,1",{"v":282277,"d":"282,277"},"0,0",298,149,1,1,"1.0,0.996","1.0,1.0",-2E-3]
[86684,"ENSG00000112031.15","MTRF1L","chr6","-",152995262,152995319,152994512,152994676,152998549,152998629,86684,"39,33","0,2","2,16","12,4",206,149,{"v":1.14420978435E-5,"d":"1.14E-05"},{"v":6.75052002738314e-05,"d":"6.75E-05"},"1.0,0.923","0.108,0.743",0.536]
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[87199,"ENSG00000181090.20","EHMT1","chr9","+",137757879,137758011,137743901,137744090,137775108,137775252,87199,"0,2","3,1","50,36","13,2",281,149,0.00142284645885,0.00588670355868855,"0.0,0.515","0.671,0.905",-0.53]
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[88281,"ENSG00000170266.15","GLB1","chr3","-",33051757,33051798,33046119,33046232,33053490,33053549,88281,"52,56","0,0","41,49","50,47",190,149,0,0,"1.0,1.0","0.391,0.45",0.58]
[88649,"ENSG00000114026.21","OGG1","chr3","+",9759186,9759286,9756766,9756816,9765808,9766737,88649,"4,1","16,24","0,0","17,11",249,149,0.035539458907,0.109685888676939,"0.13,0.024","0.0,0.0",0.077]
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[89462,"ENSG00000179051.13","RCC2","chr1","-",17425540,17425684,17416479,17416646,17438229,17438522,89462,"9,3","0,0",{"v":116126,"d":"116,126"},"16,5",293,149,0.000803025149084,3.48670761670496E-3,"1.0,1.0","0.787,0.928",0.142]
[89768,"ENSG00000126249.7","PDCD2L","chr19","+",34404648,34404990,34404424,34404538,34409160,34409510,89768,{"v":156208,"d":"156,208"},"2,2",{"v":136207,"d":"136,207"},"5,0",298,149,0.652261595377,1,"0.975,0.981","0.932,1.0",0.012]
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[90309,"ENSG00000096384.19","HSP90AB1","chr6","+",44249376,44249583,44247086,44247195,44249674,44249834,90309,{"v":1552715724,"d":"1,552,715,724"},"0,0",{"v":1417713906,"d":"1,417,713,906"},"1,0",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[90589,"ENSG00000004534.14","RBM6","chr3","+",50075172,50075330,50070454,50070552,50077007,50077249,90589,{"v":373289,"d":"373,289"},"0,3",{"v":428528,"d":"428,528"},"1,0",298,149,1,1,"1.0,0.98","0.995,1.0",-0.008]
[90702,"ENSG00000123600.19","METTL8","chr2","-",171392042,171392197,171360421,171360513,171433882,171434018,90702,{"v":163170,"d":"163,170"},"18,14","26,37","27,19",298,149,{"v":5.12107467543e-10,"d":"5.12E-10"},{"v":5.05112962764024e-09,"d":"5.05E-09"},"0.819,0.859","0.325,0.493",0.43]
[90955,"ENSG00000182095.14","TNRC18","chr7","-",5332621,5333049,5325095,5325248,5345561,5345810,90955,{"v":264289,"d":"264,289"},"3,0",{"v":571582,"d":"571,582"},"0,0",298,149,1,1,"0.978,1.0","1.0,1.0",-0.011]
[91387,"ENSG00000100060.17","MFNG","chr22","-",37480720,37480769,37480196,37480299,37484237,37484338,91387,{"v":481522,"d":"481,522"},"0,0","56,63","4,5",198,149,{"v":6.82950836967e-05,"d":"6.83E-05"},0.000356815008400245,"1.0,1.0","0.913,0.905",0.091]
[91515,"ENSG00000106133.17","NSUN5P2","chr7","-",72949312,72949491,72948891,72948980,72949845,72949961,91515,{"v":95123,"d":"95,123"},"2,2","108,96","27,27",298,149,{"v":1.36324285194E-12,"d":"1.36E-12"},{"v":1.6994776341064E-11,"d":"1.70E-11"},"0.96,0.969","0.667,0.64",0.311]
[91805,"ENSG00000204120.14","GIGYF2","chr2","+",232731121,232731258,232722553,232722658,232735154,232735238,91805,"0,5","0,5","0,0","2,2",286,149,1,1,"NA,0.343","0.0,0.0",0.343]
[92165,"ENSG00000141524.15","TMC6","chr17","-",78120652,78120832,78119296,78119392,78121555,78121711,92165,{"v":405368,"d":"405,368"},"0,0","86,86","3,4",298,149,2.72125274684E-3,0.0106432288848974,"1.0,1.0","0.935,0.915",0.075]
[92333,"ENSG00000164532.10","TBX20","chr7","-",35240878,35241037,35231499,35231580,35244948,35245057,92333,"0,10","0,0","7,13","1,0",298,149,1,1,"NA,1.0","0.778,1.0",0.111]
[92620,"ENSG00000100029.17","PES1","chr22","-",30581333,30581408,30580570,30580701,30581527,30581644,92620,{"v":280290,"d":"280,290"},"2,0",{"v":286299,"d":"286,299"},"5,2",224,149,0.775834713202,1,"0.989,1.0","0.974,0.99",0.012]
[92979,"ENSG00000106070.18","GRB10","chr7","-",50755886,50756056,50705139,50705323,50793223,50793313,92979,{"v":104148,"d":"104,148"},"0,1",{"v":87120,"d":"87,120"},"0,0",298,149,1,1,"1.0,0.987","1.0,1.0",-0.006]
[93026,"ENSG00000174485.15","DENND4A","chr15","-",65756139,65756472,65752378,65752628,65761359,65761437,93026,{"v":179141,"d":"179,141"},"2,0",{"v":184194,"d":"184,194"},"0,0",298,149,1,1,"0.978,1.0","1.0,1.0",-0.011]
[93399,"ENSG00000164669.13","INTS4P1","chr7","+",65231540,65231936,65212650,65212794,65233064,65234204,93399,"3,1","3,1","4,5","0,0",298,149,{"v":1.30877818736E-5,"d":"1.31E-05"},{"v":7.65075403001991e-05,"d":"7.65E-05"},"0.333,0.333","1.0,1.0",-0.667]
[93530,"ENSG00000147912.12","FBXO10","chr9","-",37518124,37518438,37510891,37512721,37521568,37521838,93530,"39,42","1,0","55,99","0,1",298,149,1,1,"0.951,1.0","1.0,0.98",-0.014]
[93839,"ENSG00000223705.9","NSUN5P1","chr7","+",75415591,75415778,75415119,75415234,75415980,75416126,93839,{"v":184247,"d":"184,247"},"1,4",{"v":224215,"d":"224,215"},"53,66",298,149,0,0,"0.989,0.969","0.679,0.62",0.33]
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[94338,"ENSG00000197603.13","CPLANE1","chr5","-",37226303,37227073,37224252,37224333,37227242,37227392,94338,"43,47","0,0","20,42","4,0",298,149,0.0379568443533,0.11636363554593,"1.0,1.0","0.714,1.0",0.143]
[94654,"ENSG00000197323.11","TRIM33","chr1","-",114463411,114463556,114463103,114463236,114464269,114464388,94654,{"v":473533,"d":"473,533"},"0,1",{"v":602576,"d":"602,576"},"3,2",294,149,1,1,"1.0,0.996","0.99,0.993",0.006]
[95107,"ENSG00000151503.12","NCAPD3","chr11","-",134216935,134217098,134210269,134210454,134220571,134220726,95107,{"v":13301420,"d":"13,301,420"},"15,29",{"v":455430,"d":"455,430"},"46,52",298,149,0,0,"0.978,0.961","0.832,0.805",0.151]
[95381,"ENSG00000166762.17","CATSPER2","chr15","-",43647049,43647118,43639421,43640496,43647293,43647467,95381,"23,14","0,3","7,0","0,0",218,149,1,1,"1.0,0.761","1.0,NA",-0.119]
[95500,"ENSG00000105819.13","PMPCB","chr7","+",103311642,103311728,103310314,103310475,103311807,103311896,95500,{"v":1077931,"d":"1,077,931"},"1,0",{"v":784735,"d":"784,735"},"9,11",235,149,0.0283126574501,0.0894198925697904,"0.999,1.0","0.982,0.977",0.02]
[95902,"ENSG00000245910.8","SNHG6","chr8","-",66922613,66922725,66922323,66922392,66925436,66925541,95902,{"v":84528384,"d":"84,528,384"},{"v":415410,"d":"415,410"},{"v":1178712795,"d":"1,178,712,795"},{"v":350403,"d":"350,403"},261,149,{"v":2.96493631179E-5,"d":"2.96E-05"},1.64447474067404E-4,"0.921,0.921","0.951,0.948",-0.028]
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[96682,"ENSG00000104689.9","TNFRSF10A","chr8","-",23202647,23202761,23201807,23201919,23212115,23212212,96682,{"v":236228,"d":"236,228"},"0,0",{"v":100127,"d":"100,127"},"1,3",263,149,0.830357003044,1,"1.0,1.0","0.983,0.96",0.028]
[96887,"ENSG00000157741.14","UBN2","chr7","+",139258487,139258625,139237004,139237097,139259266,139259370,96887,"59,58","0,0",{"v":134103,"d":"134,103"},"5,1",287,149,0.0376878285206,0.115612420824062,"1.0,1.0","0.933,0.982",0.042]
[97235,"ENSG00000185485.14","SDHAP1","chr3","-",195963299,195963421,195959920,195960086,195965428,195965542,97235,{"v":150123,"d":"150,123"},"21,15","15,32","38,37",271,149,0,0,"0.797,0.818","0.178,0.322",0.557]
[97517,"ENSG00000063176.15","SPHK2","chr19","+",48626067,48626362,48620401,48620553,48627691,48627841,97517,{"v":104113,"d":"104,113"},"2,4",{"v":91109,"d":"91,109"},"8,11",298,149,0.00314229367107,0.0121310981033027,"0.963,0.934","0.85,0.832",0.108]
[97923,"ENSG00000146909.7","NOM1","chr7","+",156958605,156958856,156954111,156954298,156959850,156960118,97923,"5,10",{"v":201163,"d":"201,163"},"3,18",{"v":233175,"d":"233,175"},298,149,0.516077889068,1,"0.012,0.03","0.006,0.049",-0.007]
[98101,"ENSG00000182372.9","CLN8","chr8","+",1765067,1765223,1763814,1763885,1770931,1771597,98101,"2,0","109,76","0,0","40,86",298,149,1,1,"0.009,0.0","0.0,0.0",0.004]
[98331,"ENSG00000158711.13","ELK4","chr1","-",205623675,205623891,205619267,205620838,205631631,205631893,98331,{"v":173231,"d":"173,231"},"0,0",{"v":244241,"d":"244,241"},"3,0",298,149,1,1,"1.0,1.0","0.976,1.0",0.012]
[98729,"ENSG00000078674.17","PCM1","chr8","+",17963100,17963291,17962033,17962174,17964567,17964768,98729,{"v":1165989,"d":"1,165,989"},"3,7",{"v":1080909,"d":"1,080,909"},"15,11",298,149,0.00486624328279,0.0180954875076723,"0.995,0.986","0.973,0.976",0.016]
[98752,"ENSG00000225778.5","PROSER2-AS1","chr10","-",11862816,11862930,11849607,11851756,11869365,11869501,98752,{"v":114111,"d":"114,111"},"3,1","11,16","27,55",263,149,0,0,"0.956,0.984","0.188,0.141",0.805]
[99294,"ENSG00000104290.10","FZD3","chr8","+",28499932,28499978,28494255,28494343,28502669,28503202,99294,"40,35","13,17","5,1","21,14",195,149,{"v":2.79093526068e-10,"d":"2.79E-10"},{"v":2.82287108158671e-09,"d":"2.82E-09"},"0.702,0.611","0.154,0.052",0.553]
[99298,"ENSG00000104299.14","INTS9","chr8","-",28770981,28771080,28769600,28770026,28775758,28775925,99298,{"v":441384,"d":"441,384"},"0,1",{"v":307320,"d":"307,320"},"0,4",248,149,1,1,"1.0,0.996","1.0,0.98",0.008]
[99594,"ENSG00000204370.10","SDHD","chr11","+",112107544,112107708,112088866,112089011,112119291,112119442,99594,"2,5","23,7","4,4","4,4",298,149,0.0534282817634,0.158303366818751,"0.042,0.263","0.333,0.333",-0.181]
[99854,"ENSG00000145604.15","SKP2","chr5","+",36163644,36163756,36152770,36153042,36176964,36177016,99854,{"v":290313,"d":"290,313"},"5,1",{"v":151140,"d":"151,140"},"60,86",261,149,0,0,"0.971,0.994","0.59,0.482",0.446]
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[23,"ENSG00000198753.11","PLXNB3","chrX","+",153777527,153778095,153777527,153777688,153777947,153778095,23,"20,20","28,32","32,29","47,51",298,149,0.851939019803,0.999616876598722,"0.263,0.238","0.254,0.221",0.013]
[24,"ENSG00000063587.14","ZNF275","chrX","+",153346818,153352926,153346818,153347655,153347753,153352926,24,"44,85","0,0","83,91","0,4",247,149,0.490998967165,0.662248464808961,"1.0,1.0","1.0,0.932",0.034]
[26,"ENSG00000147400.8","CETN2","chrX","-",152828536,152829277,152828536,152828674,152829148,152829277,26,"2,2",274220,"0,1",145215,298,149,1,1,"0.004,0.005","0.0,0.002",0.004]
[30,"ENSG00000063601.16","MTMR1","chrX","+",150762564,150765102,150762564,150762737,150764511,150765102,30,"72,99","1,0","78,65","0,0",298,149,1,1,"0.973,1.0","1.0,1.0",-0.014]
[31,"ENSG00000269556.7","TMEM185A","chrX","-",149596556,149598255,149596556,149597182,149597260,149598255,31,"18,46","4,0","58,35","5,3",227,149,0.527340285963,0.700316164817921,"0.747,1.0","0.884,0.884",-0.011]
[35,"ENSG00000165359.15","INTS6L","chrX","+",135569336,135573033,135569336,135569431,135572814,135573033,35,140125,"23,16",103102,"2,0",298,149,{"v":2.00766714364E-9,"d":"2.01E-09"},{"v":1.16888105479408E-8,"d":"1.17E-08"},"0.753,0.796","0.963,1.0",-0.207]
[37,"ENSG00000102034.16","ELF4","chrX","-",130069299,130069677,130069299,130069482,130069484,130069677,37,328361,"1,0",391330,"0,0",151,149,1,1,"0.997,1.0","1.0,1.0",-2E-3]
[38,"ENSG00000102034.16","ELF4","chrX","-",130081255,130081539,130081255,130081312,130081436,130081539,38,290300,"2,3",260309,"5,4",273,149,0.200536084392,0.315289503127912,"0.988,0.982","0.966,0.977",0.013]
[41,"ENSG00000089682.16","RBM41","chrX","-",107088435,107088839,107088435,107088573,107088734,107088839,41,363338,"7,5",266241,"4,14",298,149,0.0595192395108,0.108748090673371,"0.963,0.971","0.971,0.896",0.033]
[42,"ENSG00000147206.16","NXF3","chrX","-",103079762,103080216,103079762,103079870,103080147,103080216,42,439457,"18,9",779773,"34,59",298,149,0.00222767397441,0.00569521175031004,"0.924,0.962","0.92,0.868",0.049]
[45,"ENSG00000147180.16","ZNF711","chrX","+",85246929,85247651,85246929,85247183,85247546,85247651,45,"68,49","9,8","29,15","2,3",298,149,0.415169373559,0.578554677690882,"0.791,0.754","0.879,0.714",-0.024]
[47,"ENSG00000147099.20","HDAC8","chrX","-",72329567,72330876,72329567,72330076,72330815,72330876,47,"40,44","5,7",118137,"16,37",298,149,0.268683144776,0.40359158239474,"0.8,0.759","0.787,0.649",0.062]
[48,"ENSG00000147099.20","HDAC8","chrX","-",72567581,72568030,72567581,72567796,72567888,72568030,48,"71,21","49,29","50,67","11,12",241,149,{"v":2.07630560545e-06,"d":"2.08E-06"},{"v":8.58194259395492e-06,"d":"8.58E-06"},"0.473,0.309","0.738,0.775",-0.365]
[50,"ENSG00000184634.15","MED12","chrX","+",71137725,71137943,71137725,71137780,71137855,71137943,50,615701,"62,67",421407,"2,5",224,149,0,0,"0.868,0.874","0.993,0.982",-0.117]
[51,"ENSG00000204271.12","SPIN3","chrX","-",56978291,56978660,56978291,56978417,56978579,56978660,51,"4,0","0,0","10,4","1,0",298,149,1,1,"1.0,NA","0.833,1.0",0.084]
[52,"ENSG00000204271.12","SPIN3","chrX","-",56978291,56978660,56978291,56978421,56978579,56978660,52,"4,0","0,0","10,4","2,8",298,149,1,1,"1.0,NA","0.714,0.2",0.543]
[53,"ENSG00000204271.12","SPIN3","chrX","-",56978291,56978660,56978291,56978498,56978579,56978660,53,"2,0","0,0","6,4","2,0",230,149,1,1,"1.0,NA","0.66,1.0",0.17]
[54,"ENSG00000204271.12","SPIN3","chrX","-",56993786,56994949,56993786,56993888,56994722,56994949,54,"21,21","5,6","42,40","0,2",298,149,{"v":3.31219891855e-05,"d":"3.31E-05"},1.13886839626954E-4,"0.677,0.636","1.0,0.909",-0.298]
[55,"ENSG00000102349.17","KLF8","chrX","+",56265179,56269489,56265179,56265744,56269377,56269489,55,"7,4","6,6","3,0","6,18",298,149,0.00191424664091,0.00495802418729145,"0.368,0.25","0.2,0.0",0.209]
[56,"ENSG00000126012.11","KDM5C","chrX","-",53198489,53198888,53198489,53198637,53198763,53198888,56,149152,404444,221185,410429,275,149,0.0219807901119,0.0453276180273644,"0.167,0.156","0.226,0.189",-0.046]
[57,"ENSG00000184205.14","TSPYL2","chrX","+",53084531,53084866,53084531,53084622,53084754,53084866,57,"45,37",97119,"80,80",115117,281,149,1.65647117284E-3,0.00433533133763144,"0.197,0.142","0.269,0.266",-0.098]
[62,"ENSG00000049768.14","FOXP3","chrX","-",49251333,49251765,49251333,49251483,49251663,49251765,62,"2,0","0,3","1,2","1,0",298,149,0.0104884579391,0.0235977870654478,"1.0,0.0","0.333,1.0",-0.166]
[64,"ENSG00000269313.5","MAGIX","chrX","+",49164706,49165090,49164706,49164789,49164862,49165090,64,"5,4","0,3","5,5","2,2",222,149,0.368084494505,0.52623107153547,"1.0,0.472","0.627,0.627",0.109]
[65,"ENSG00000269313.5","MAGIX","chrX","+",49164706,49165090,49164706,49164789,49164907,49165090,65,"7,9","4,7","6,5","2,2",267,149,0.268765685685,0.40359158239474,"0.494,0.418","0.626,0.582",-0.148]
[66,"ENSG00000196998.17","WDR45","chrX","-",49076644,49077911,49076644,49076750,49077836,49077911,66,"67,67","48,52",168146,"26,43",298,149,{"v":5.89234652626e-07,"d":"5.89E-07"},{"v":2.61545222330249e-06,"d":"2.62E-06"},"0.411,0.392","0.764,0.629",-0.295]
[67,"ENSG00000196998.17","WDR45","chrX","-",49076644,49077911,49076644,49076753,49077836,49077911,67,"67,66","2,5",167151,"6,5",298,149,0.610296429871,0.778037764572244,"0.944,0.868","0.933,0.938",-0.03]
[68,"ENSG00000196998.17","WDR45","chrX","-",49076644,49077911,49076644,49076804,49077836,49077911,68,"66,57","0,0",158145,"1,0",298,149,1,1,"1.0,1.0","0.988,1.0",0.006]
[69,"ENSG00000196998.17","WDR45","chrX","-",49100581,49101144,49100581,49100677,49101049,49101144,69,"28,63","1,3","40,26","6,0",298,149,0.455548031144,0.623291640074475,"0.933,0.913","0.769,1.0",0.038]
[70,"ENSG00000068308.13","OTUD5","chrX","-",48934463,48934867,48934463,48934612,48934695,48934867,70,"64,94","44,31","58,60","28,38",232,149,0.5965732626,0.764651575104538,"0.483,0.661","0.571,0.503",0.035]
[71,"ENSG00000068308.13","OTUD5","chrX","-",48934463,48934867,48934463,48934612,48934710,48934867,71,"66,97",10061011,"64,70",657685,247,149,0.183582732314,0.292708355117584,"0.038,0.055","0.056,0.058",-0.011]
[72,"ENSG00000094631.19","HDAC6","chrX","+",48805630,48806464,48805630,48805671,48806367,48806464,72,"43,36",410312,120154,"80,74",298,149,0,0,"0.05,0.055","0.429,0.51",-0.417]
[74,"ENSG00000094631.19","HDAC6","chrX","+",48814674,48814893,48814674,48814740,48814833,48814893,74,125144,229275,"116,80","52,59",242,149,{"v":1.25176646826E-8,"d":"1.25E-08"},{"v":6.76495659668986e-08,"d":"6.76E-08"},"0.252,0.244","0.579,0.455",-0.269]
[75,"ENSG00000094631.19","HDAC6","chrX","+",48814961,48815490,48814961,48815051,48815383,48815490,75,219208,210214,"144,95","41,42",298,149,{"v":1.42745052667e-07,"d":"1.43E-07"},{"v":6.78003278183098e-07,"d":"6.78E-07"},"0.343,0.327","0.637,0.531",-0.249]
[76,"ENSG00000094631.19","HDAC6","chrX","+",48818040,48818412,48818040,48818109,48818219,48818412,76,"55,56",257311,78107,"102,97",259,149,0,0,"0.11,0.094","0.306,0.388",-0.245]
[77,"ENSG00000094631.19","HDAC6","chrX","+",48822911,48823588,48822911,48823018,48823120,48823588,77,800828,"2,2",313342,"4,2",251,149,0.653551845578,0.818881306381729,"0.996,0.996","0.979,0.99",0.012]
[78,"ENSG00000102317.17","RBM3","chrX","+",48575560,48576083,48575560,48575667,48575814,48576083,78,297323,"24,37",298277,"73,86",296,149,{"v":1.53101203937e-08,"d":"1.53E-08"},{"v":8.19938163296912e-08,"d":"8.20E-08"},"0.862,0.815","0.673,0.619",0.193]
[79,"ENSG00000102317.17","RBM3","chrX","+",48575560,48576083,48575560,48575667,48575921,48576083,79,466518,"17,11",542625,"0,0",298,149,{"v":4.84773157172e-08,"d":"4.85E-08"},{"v":2.46279296657509E-7,"d":"2.46E-07"},"0.932,0.959","1.0,1.0",-0.054]
[80,"ENSG00000102312.21","PORCN","chrX","+",48511891,48512507,48511891,48511935,48512325,48512507,80,"6,16","17,16","13,35","16,12",298,149,0.0791333322841,0.140002856706955,"0.15,0.333","0.289,0.593",-0.199]
[82,"ENSG00000102226.9","USP11","chrX","+",47239350,47239907,47239350,47239481,47239789,47239907,82,"49,19",412401,"49,34",220181,298,149,{"v":6.31530332085e-06,"d":"6.32E-06"},{"v":2.4482119491367E-5,"d":"2.45E-05"},"0.056,0.023","0.1,0.086",-0.053]
[83,"ENSG00000102226.9","USP11","chrX","+",47247071,47247419,47247071,47247221,47247303,47247419,83,68106,648602,"28,11",347323,231,149,{"v":7.13350288273e-06,"d":"7.13E-06"},{"v":2.74521258544637e-05,"d":"2.75E-05"},"0.063,0.102","0.049,0.021",0.047]
[84,"ENSG00000102226.9","USP11","chrX","+",47247303,47247699,47247303,47247419,47247610,47247699,84,"105,78",608686,"67,49",320264,298,149,0.0449357730181,0.0850160458416604,"0.079,0.054","0.095,0.085",-0.023]
[86,"ENSG00000182220.14","ATP6AP2","chrX","+",40599591,40600881,40599591,40599741,40600761,40600881,86,"14,13",16121467,"23,18",13841554,298,149,1,1,"0.004,0.004","0.008,0.006",-0.003]
[87,"ENSG00000182220.14","ATP6AP2","chrX","+",40599591,40600881,40599591,40599741,40600768,40600881,87,"30,32","6,7","40,35","4,3",298,149,0.0805799161922,0.14224393687946,"0.714,0.696","0.833,0.854",-0.138]
[88,"ENSG00000182220.14","ATP6AP2","chrX","+",40599591,40600881,40599591,40599741,40600781,40600881,88,"81,59","8,11","91,75","12,8",298,149,0.761563834792,0.919496283991867,"0.835,0.728","0.791,0.824",-0.026]
[89,"ENSG00000102230.13","PCYT1B","chrX","-",24561841,24562505,24561841,24562117,24562442,24562505,89,105111,"0,3",79101,"0,1",298,149,0.456312385337,0.623977598969471,"1.0,0.949","1.0,0.981",-0.016]
[90,"ENSG00000149970.15","CNKSR2","chrX","+",21591021,21595047,21591021,21591194,21594973,21595047,90,"2,0","24,17","3,0","13,11",298,149,0.501279447356,0.672292531855347,"0.04,0.0","0.103,0.0",-0.032]
[91,"ENSG00000102054.17","RBBP7","chrX","-",16845827,16849301,16845827,16845938,16849243,16849301,91,"13,17",803734,"42,35",591586,298,149,{"v":1.37420911206e-07,"d":"1.37E-07"},{"v":6.5537398413807e-07,"d":"6.55E-07"},"0.008,0.011","0.034,0.029",-0.022]
[92,"ENSG00000165195.15","PIGA","chrX","-",15324664,15325152,15324664,15324871,15325019,15325152,92,"4,9","55,34","10,12","23,22",297,149,0.00260529297817,0.00658259594324635,"0.035,0.117","0.179,0.215",-0.121]
[93,"ENSG00000165195.15","PIGA","chrX","-",15331215,15331992,15331215,15331299,15331873,15331992,93,"79,58","2,0","59,63","0,0",298,149,0.406391618139,0.568996231357201,"0.952,1.0","1.0,1.0",-0.024]
[94,"ENSG00000068438.14","FTSJ1","chrX","+",48477960,48478518,48477960,48478168,48478448,48478518,94,89111,706664,156141,281252,298,149,0,0,"0.059,0.077","0.217,0.219",-0.15]
[95,"ENSG00000068438.14","FTSJ1","chrX","+",48481425,48481715,48481425,48481528,48481631,48481715,95,"66,49",709688,123171,255360,252,149,0,0,"0.052,0.04","0.222,0.219",-0.174]
[96,"ENSG00000068438.14","FTSJ1","chrX","+",48482596,48483027,48482596,48482794,48482985,48483027,96,306363,613621,291378,175186,298,149,0,0,"0.2,0.226","0.454,0.504",-0.266]
[97,"ENSG00000073464.11","CLCN4","chrX","+",10208044,10208590,10208044,10208181,10208274,10208590,97,313371,"8,14",291281,"5,7",242,149,0.203267070896,0.318527824108824,"0.96,0.942","0.973,0.961",-0.016]
[100,"ENSG00000100299.17","ARSA","chr22","-",50626590,50627406,50626590,50626760,50627165,50627406,100,"50,60","0,4","67,75","2,1",298,149,0.869755627705,1,"1.0,0.882","0.944,0.974",-0.018]
[101,"ENSG00000100299.17","ARSA","chr22","-",50627555,50628170,50627555,50627792,50627945,50628170,101,"61,83","29,40",127168,"10,2",298,149,{"v":1.7763568394E-15,"d":"1.78E-15"},{"v":1.7670467930719e-14,"d":"1.77E-14"},"0.513,0.509","0.864,0.977",-0.409]
[102,"ENSG00000100288.19","CHKB","chr22","-",50580189,50580416,50580189,50580271,50580357,50580416,102,254212,328272,296381,101117,235,149,0,0,"0.329,0.331","0.65,0.674",-0.332]
[103,"ENSG00000100288.19","CHKB","chr22","-",50581748,50582357,50581748,50581862,50582248,50582357,103,373378,"65,72",353366,"33,39",298,149,0.000851179696407,0.00233729609921945,"0.742,0.724","0.842,0.824",-0.1]
[104,"ENSG00000025770.18","NCAPH2","chr22","+",50523016,50523472,50523016,50523166,50523234,50523472,104,"36,72",684824,147137,498536,217,149,0,0,"0.035,0.057","0.169,0.149",-0.113]
[105,"ENSG00000100258.17","LMF2","chr22","-",50504339,50504727,50504339,50504451,50504558,50504727,105,"40,61",294326,"16,23",145197,256,149,0.0872494094509,0.152879781331063,"0.073,0.098","0.06,0.064",0.023]
[106,"ENSG00000100258.17","LMF2","chr22","-",50505056,50505537,50505056,50505153,50505402,50505537,106,88112,"8,4","88,97","10,12",298,149,0.0600619382832,0.10965521244855,"0.846,0.933","0.815,0.802",0.081]
[107,"ENSG00000100241.20","SBF1","chr22","-",50447321,50447609,50447321,50447453,50447521,50447609,107,"4,4",233270,"15,13",218232,217,149,0.000179353258121,0.000546233125663764,"0.012,0.01","0.045,0.037",-0.03]
[108,"ENSG00000100241.20","SBF1","chr22","-",50467531,50467923,50467531,50467690,50467785,50467923,108,"10,2",132142,"6,8",108171,244,149,0.762618704977,0.920067570586286,"0.044,0.009","0.033,0.028",-0.004]
[109,"ENSG00000100241.20","SBF1","chr22","-",50467531,50467923,50467531,50467693,50467785,50467923,109,"9,1","50,21","6,7","33,44",241,149,0.779857332846,0.935395107268521,"0.1,0.029","0.101,0.09",-0.031]
[110,"ENSG00000205593.11","DENND6B","chr22","-",50313813,50314272,50313813,50313878,50314206,50314272,110,"20,16",75129,"32,39","56,48",298,149,{"v":8.5798960936e-08,"d":"8.58E-08"},{"v":4.21445206668033E-7,"d":"4.21E-07"},"0.118,0.058","0.222,0.289",-0.168]
[116,"ENSG00000196576.14","PLXNB2","chr22","-",50278854,50279011,50278854,50278881,50278882,50279011,116,268284,"0,0",201228,"0,1",150,149,1,1,"1.0,1.0","1.0,0.996",2E-3]
[117,"ENSG00000196576.14","PLXNB2","chr22","-",50281359,50281742,50281359,50281499,50281565,50281742,117,"27,40",178171,"23,47",136120,215,149,0.15052138959,0.245775634413128,"0.095,0.139","0.105,0.213",-0.042]
[118,"ENSG00000100429.17","HDAC10","chr22","-",50245674,50246092,50245674,50245827,50245909,50246092,118,"72,86",133121,"89,88",105140,231,149,0.373794089509,0.532948604182753,"0.259,0.314","0.353,0.288",-0.034]
[119,"ENSG00000100429.17","HDAC10","chr22","-",50246297,50246735,50246297,50246376,50246678,50246735,119,"70,67",125126,152152,84117,298,149,{"v":9.4971716047e-09,"d":"9.50E-09"},{"v":5.22785142277279e-08,"d":"5.23E-08"},"0.219,0.21","0.475,0.394",-0.22]
[120,"ENSG00000100429.17","HDAC10","chr22","-",50246678,50246966,50246678,50246735,50246874,50246966,120,"31,24",152128,"34,49",149164,288,149,0.156757601479,0.25481836896809,"0.095,0.088","0.106,0.134",-0.028]
[121,"ENSG00000100429.17","HDAC10","chr22","-",50248224,50248472,50248224,50248292,50248365,50248472,121,"79,89",169226,115153,114156,222,149,{"v":1.24279911584e-07,"d":"1.24E-07"},{"v":6.01129643696309e-07,"d":"6.01E-07"},"0.239,0.209","0.404,0.397",-0.177]
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[123,"ENSG00000170638.9","TRABD","chr22","+",50197822,50198186,50197822,50197995,50198074,50198186,123,459511,434456,319363,235267,228,149,0.0770928331612,0.137057135013073,"0.409,0.423","0.47,0.47",-0.054]
[124,"ENSG00000100416.13","TRMU","chr22","+",46355443,46357337,46355443,46355588,46356841,46357337,124,"73,84","22,12",97112,76108,298,149,{"v":2.63810732148e-07,"d":"2.64E-07"},{"v":1.2212506576022e-06,"d":"1.22E-06"},"0.624,0.778","0.39,0.341",0.336]
[127,"ENSG00000237037.9","NDUFA6-DT","chr22","+",42124046,42124562,42124046,42124130,42124519,42124562,127,"3,3","4,13","1,4","15,4",298,149,0.741073665172,0.902565333994132,"0.273,0.103","0.032,0.333",0.006]
[128,"ENSG00000237037.9","NDUFA6-DT","chr22","+",42136198,42136714,42136198,42136282,42136671,42136714,128,"4,3","1,0","1,2","4,6",298,149,{"v":1.55458014658e-05,"d":"1.55E-05"},{"v":5.66115333501312e-05,"d":"5.66E-05"},"0.667,1.0","0.111,0.143",0.707]
[129,"ENSG00000198951.11","NAGA","chr22","-",42070281,42070830,42070281,42070366,42070762,42070830,129,258256,"5,9",145134,"8,2",298,149,0.688943771432,0.85197763759313,"0.963,0.934","0.901,0.971",0.013]
[130,"ENSG00000100395.14","L3MBTL2","chr22","+",41217122,41219536,41217122,41217202,41219418,41219536,130,"37,26",166232,"31,59",114100,298,149,{"v":3.43150567432e-05,"d":"3.43E-05"},1.17478314752152E-4,"0.1,0.053","0.12,0.228",-0.097]
[131,"ENSG00000100395.14","L3MBTL2","chr22","+",41227088,41227869,41227088,41227323,41227803,41227869,131,"55,47",220199,"24,9",197180,298,149,{"v":3.21593641428E-6,"d":"3.22E-06"},{"v":1.2920929962539E-5,"d":"1.29E-05"},"0.111,0.106","0.057,0.024",0.068]
[134,"ENSG00000100242.15","SUN2","chr22","-",38740266,38741050,38740266,38740432,38740888,38741050,134,"27,29","1,2",97100,"14,1",298,149,0.383166636715,0.54210425743101,"0.931,0.879","0.776,0.98",0.027]
[135,"ENSG00000100242.15","SUN2","chr22","-",38740266,38741050,38740266,38740432,38741006,38741050,135,"35,41",193140,147156,303301,298,149,{"v":4.20081012698e-06,"d":"4.20E-06"},{"v":1.67221846078188e-05,"d":"1.67E-05"},"0.083,0.128","0.195,0.206",-0.095]
[136,"ENSG00000100242.15","SUN2","chr22","-",38750897,38751373,38750897,38751035,38751209,38751373,136,"18,13",113153,"15,14",206240,298,149,0.0468430529527,0.0881325480811108,"0.074,0.041","0.035,0.028",0.026]
[137,"ENSG00000100201.20","DDX17","chr22","-",38487878,38492115,38487878,38488115,38492055,38492115,137,37343648,14181416,41853954,15251546,298,149,0.873941393725,1,"0.568,0.563","0.578,0.561",-0.004]
[138,"ENSG00000100151.15","PICK1","chr22","+",38073772,38074451,38073772,38073823,38074306,38074451,138,"17,40","46,82","75,98","48,38",298,149,{"v":2.0950686741e-09,"d":"2.10E-09"},{"v":1.2167810108451e-08,"d":"1.22E-08"},"0.156,0.196","0.439,0.563",-0.325]
[139,"ENSG00000100097.11","LGALS1","chr22","+",37678375,37678654,37678375,37678392,37678482,37678654,139,"17,6","0,0","13,25","0,2",239,149,0.507016586558,0.678090010635472,"1.0,1.0","1.0,0.886",0.057]
[140,"ENSG00000133466.13","C1QTNF6","chr22","-",37180166,37182735,37180166,37180867,37182151,37182735,140,"55,40","3,7",89108,"0,3",298,149,0.000869567218759,2.38386968255934E-3,"0.902,0.741","1.0,0.947",-0.152]
[141,"ENSG00000100365.14","NCF4","chr22","+",36875652,36876094,36875652,36875783,36876028,36876094,141,1013899,12471164,843969,12091412,298,149,0.214338047352,0.333126116831064,"0.289,0.279","0.259,0.255",0.027]
[142,"ENSG00000100360.14","IFT27","chr22","-",36758210,36764036,36758210,36758409,36763918,36764036,142,"93,74","80,54","84,78","71,61",298,149,0.927027293482,1,"0.368,0.407","0.372,0.39",0.006]
[143,"ENSG00000100360.14","IFT27","chr22","-",36775673,36776125,36775673,36775794,36776030,36776125,143,194172,"6,11",94134,"2,0",298,149,0.000583741110309,1.63993580131214E-3,"0.942,0.887","0.959,1.0",-0.065]
[144,"ENSG00000100353.17","EIF3D","chr22","-",36525663,36526131,36525663,36525709,36525998,36526131,144,"59,56",33243130,"13,17",12911432,298,149,1,1,"0.009,0.009","0.005,0.006",0.003]
[149,"ENSG00000128284.19","APOL3","chr22","-",36149045,36149371,36149045,36149142,36149258,36149371,149,"4,20","2,5","2,2","3,0",265,149,0.970875074151,1,"0.529,0.692","0.273,1.0",-0.026]
[150,"ENSG00000138942.15","RNF185","chr22","+",31204488,31207013,31204488,31204966,31205376,31207013,150,463457,"4,0",503558,"0,0",298,149,1,1,"0.983,1.0","1.0,1.0",-0.008]
[152,"ENSG00000185133.13","INPP5J","chr22","+",31133609,31134696,31133609,31133714,31133912,31134696,152,"0,0","7,5","2,2","2,3",298,149,0.00335455110654,0.00833805395522907,"0.0,0.0","0.333,0.25",-0.291]
[153,"ENSG00000183963.18","SMTN","chr22","+",31080449,31080754,31080449,31080569,31080675,31080754,153,225223,"62,32","34,44","2,8",255,149,0.132766607475,0.219887452868717,"0.68,0.803","0.909,0.763",-0.095]
[154,"ENSG00000183963.18","SMTN","chr22","+",31096997,31097338,31096997,31097060,31097268,31097338,154,111106,230212,"18,21",110114,298,149,{"v":2.77221652856e-07,"d":"2.77E-07"},{"v":1.28208259532331E-6,"d":"1.28E-06"},"0.194,0.2","0.076,0.084",0.117]
[155,"ENSG00000183963.18","SMTN","chr22","+",31099061,31099896,31099061,31099179,31099744,31099896,155,"7,10",311247,"6,8",120131,298,149,0.169386972077,0.2726936688534,"0.011,0.02","0.024,0.03",-0.011]
[156,"ENSG00000100003.17","SEC14L2","chr22","+",30415758,30416087,30415758,30415865,30415947,30416087,156,"0,0","0,2","9,0","1,2",231,149,1,1,"NA,0.0","0.853,0.0",-0.426]
[157,"ENSG00000099999.14","RNF215","chr22","-",30379481,30379780,30379481,30379622,30379710,30379780,157,"28,65","36,53","29,25","60,69",237,149,0.000512517771803,0.00145884632705772,"0.328,0.435","0.233,0.186",0.172]
[158,"ENSG00000186575.17","NF2","chr22","+",29683019,29683915,29683019,29683064,29683700,29683915,158,"13,16","1,1","24,26","0,0",298,149,0.309161201381,0.455156655461633,"0.867,0.889","1.0,1.0",-0.122]
[159,"ENSG00000100296.13","THOC5","chr22","-",29528273,29528466,29528273,29528359,29528425,29528466,159,"32,19","0,2","50,50","0,1",215,149,0.947655916989,1,"1.0,0.868","1.0,0.972",-0.052]
[160,"ENSG00000100296.13","THOC5","chr22","-",29544459,29544603,29544459,29544508,29544579,29544603,160,763617,"31,31",372474,"31,28",220,149,0.0413437558668,0.0791351841823178,"0.943,0.931","0.89,0.92",0.032]
[161,"ENSG00000100276.9","RASL10A","chr22","-",29312932,29313987,29312932,29313568,29313862,29313987,161,"8,2","1,9","9,6","0,9",298,149,0.342345278987,0.495403583041572,"0.8,0.1","1.0,0.25",-0.175]
[162,"ENSG00000100099.20","HPS4","chr22","-",26465454,26466262,26465454,26465551,26466225,26466262,162,116168,214303,588588,244232,298,149,0,0,"0.213,0.217","0.546,0.559",-0.338]
[163,"ENSG00000100099.20","HPS4","chr22","-",26466225,26468623,26466225,26466262,26468550,26468623,163,96122,218311,486416,253234,298,149,0,0,"0.18,0.164","0.49,0.471",-0.308]
[165,"ENSG00000100031.18","GGT1","chr22","+",24610249,24610531,24610249,24610336,24610413,24610531,165,"33,33","1,0","33,12","0,0",226,149,1,1,"0.956,1.0","1.0,1.0",-0.022]
[166,"ENSG00000100031.18","GGT1","chr22","+",24610249,24610531,24610249,24610336,24610454,24610531,166,"47,38","0,0","45,29","7,1",267,149,1.20912816712E-4,0.000380458431895517,"1.0,1.0","0.782,0.942",0.138]
[168,"ENSG00000100031.18","GGT1","chr22","+",24628080,24628388,24628080,24628193,24628274,24628388,168,"0,0","44,68","2,2","68,62",230,149,0.536736806846,0.708629980101355,"0.0,0.0","0.019,0.02",-0.019]
[174,"ENSG00000100023.18","PPIL2","chr22","+",21694936,21695496,21694936,21695070,21695393,21695496,174,"31,37",206174,"28,44",173199,298,149,0.731421111966,0.894021941339173,"0.07,0.096","0.075,0.1",-0.004]
[175,"ENSG00000100023.18","PPIL2","chr22","+",21694936,21695496,21694936,21695070,21695397,21695496,175,"46,45","15,20","38,48","4,14",298,149,0.0849288581341,0.149420627306749,"0.605,0.529","0.826,0.632",-0.162]
[176,"ENSG00000161179.13","YDJC","chr22","-",21629009,21629407,21629009,21629187,21629307,21629407,176,"35,66",71156,69109,"44,24",269,149,{"v":1.91613798384E-7,"d":"1.92E-07"},{"v":8.99315008241424e-07,"d":"8.99E-07"},"0.214,0.19","0.465,0.716",-0.389]
[177,"ENSG00000161179.13","YDJC","chr22","-",21629307,21629761,21629307,21629407,21629542,21629761,177,74118,"45,54",195278,"6,10",284,149,0,0,"0.463,0.534","0.945,0.936",-0.442]
[178,"ENSG00000161179.13","YDJC","chr22","-",21629009,21629761,21629009,21629407,21629601,21629761,178,202233,"66,73",305388,"8,16",298,149,0,0,"0.605,0.615","0.95,0.924",-0.327]
[179,"ENSG00000206140.10","TMEM191C","chr22","+",21467893,21468202,21467893,21468017,21468151,21468202,179,"2,0","0,2","5,1","0,2",283,149,0.181855315431,0.290637747295417,"1.0,0.0","1.0,0.208",-0.104]
[181,"ENSG00000206140.10","TMEM191C","chr22","+",21467893,21468431,21467893,21468202,21468314,21468431,181,"10,8","4,4","9,9","0,0",261,149,{"v":3.64430105226e-06,"d":"3.64E-06"},{"v":1.46049058217683e-05,"d":"1.46E-05"},"0.588,0.533","1.0,1.0",-0.44]
[183,"ENSG00000206140.10","TMEM191C","chr22","+",21468943,21469346,21468943,21469062,21469273,21469346,183,"0,2","0,0","0,0","1,1",298,149,1,1,"NA,1.0","0.0,0.0",1]
[184,"ENSG00000206140.10","TMEM191C","chr22","+",21469273,21469534,21469273,21469346,21469493,21469534,184,"0,0","2,0","2,1","0,0",296,149,1,1,"0.0,NA","1.0,1.0",-1]
[185,"ENSG00000206140.10","TMEM191C","chr22","+",21469493,21469933,21469493,21469534,21469616,21469933,185,"2,0","1,0","2,4","0,0",231,149,1,1,"0.563,NA","1.0,1.0",-0.437]
[186,"ENSG00000184436.11","THAP7","chr22","-",21000646,21001411,21000646,21000787,21001255,21001411,186,103117,347337,236270,"87,96",298,149,0,0,"0.129,0.148","0.576,0.584",-0.441]
[187,"ENSG00000099949.19","LZTR1","chr22","+",20994103,20994727,20994103,20994269,20994557,20994727,187,"61,65","31,20",142192,"8,5",298,149,{"v":6.39710506789e-13,"d":"6.40E-13"},{"v":5.2974281932178e-12,"d":"5.30E-12"},"0.496,0.619","0.899,0.95",-0.367]
[188,"ENSG00000099949.19","LZTR1","chr22","+",20994869,20995872,20994869,20995026,20995745,20995872,188,"31,36",96105,"16,19",167139,298,149,{"v":9.46448977324e-06,"d":"9.46E-06"},{"v":3.56214100472613e-05,"d":"3.56E-05"},"0.139,0.146","0.046,0.064",0.088]
[189,"ENSG00000099949.19","LZTR1","chr22","+",20995962,20996801,20995962,20996112,20996695,20996801,189,"30,26","117,91","25,23",100134,298,149,0.258870983824,0.391316603454883,"0.114,0.125","0.111,0.079",0.024]
[190,"ENSG00000099949.19","LZTR1","chr22","+",20996695,20996966,20996695,20996801,20996885,20996966,190,"17,33",174172,116145,"96,81",233,149,0,0,"0.059,0.109","0.436,0.534",-0.401]
[192,"ENSG00000226287.8","TMEM191A","chr22","+",20703632,20704040,20703632,20703751,20703967,20704040,192,"0,4","7,4","0,0","7,21",298,149,0.0371304449907,0.0721474043738212,"0.0,0.333","0.0,0.0",0.167]
[193,"ENSG00000128191.15","DGCR8","chr22","+",20089668,20090258,20089668,20089811,20089975,20090258,193,216182,353336,"85,79",286289,298,149,{"v":1.32524834684e-06,"d":"1.33E-06"},{"v":5.62460054182093e-06,"d":"5.62E-06"},"0.234,0.213","0.129,0.12",0.099]
[194,"ENSG00000184702.19","2024-09-05","chr22","+",19721821,19722339,19721821,19721957,19722236,19722339,194,"38,60",485640,"74,66",229302,298,149,{"v":1.01607500191E-10,"d":"1.02E-10"},{"v":6.76195776165911e-10,"d":"6.76E-10"},"0.038,0.045","0.139,0.099",-0.078]
[195,"ENSG00000184702.19","2024-09-05","chr22","+",19722236,19723319,19722236,19722339,19722427,19723319,195,"2,1",331420,"6,2",229241,237,149,1,1,"0.004,0.001","0.016,0.005",-0.008]
[196,"ENSG00000070010.18","UFD1","chr22","-",19450620,19454830,19450620,19450744,19454801,19454830,196,295257,"3,5",405362,"12,3",298,149,0.448380093258,0.615436373303213,"0.98,0.963","0.944,0.984",0.008]
[197,"ENSG00000070371.15","CLTCL1","chr22","-",19196265,19196656,19196265,19196415,19196488,19196656,197,"4,7","9,7","2,0","0,0",222,149,1,1,"0.23,0.402","1.0,NA",-0.684]
[198,"ENSG00000100075.9","SLC25A1","chr22","-",19177726,19178041,19177726,19177865,19177941,19178041,198,"7,15",263315,"15,0","42,52",225,149,4.36175324815E-3,0.0105864548145635,"0.017,0.031","0.191,0.0",-0.072]
[199,"ENSG00000187325.4","TAF9B","chrX","-",78137748,78138098,78137748,78137883,78137961,78138098,199,"3,1",147126,"0,0","53,48",227,149,1,1,"0.013,0.005","0.0,0.0",0.009]
[204,"ENSG00000274602.4","PI4KAP1","chr22","-",18536649,18537412,18536649,18536808,18537294,18537412,204,149182,"0,2",126170,"0,0",298,149,1,1,"1.0,0.978","1.0,1.0",-0.011]
[205,"ENSG00000274602.4","PI4KAP1","chr22","-",18548010,18548469,18548010,18548118,18548317,18548469,205,"11,11","111,80","10,6","51,80",298,149,0.95072805163,1,"0.047,0.064","0.089,0.036",-0.007]
[207,"ENSG00000278558.4","TMEM191B","chr22","+",18529605,18530008,18529605,18529724,18529935,18530008,207,"2,5","2,3","0,0","1,5",298,149,{"v":2.38915310319e-05,"d":"2.39E-05"},{"v":8.43491925196171e-05,"d":"8.43E-05"},"0.333,0.455","0.0,0.0",0.394]
[208,"ENSG00000278558.4","TMEM191B","chr22","+",18529935,18530196,18529935,18530008,18530155,18530196,208,"4,0","0,6","2,2","0,6",296,149,0.61989694453,0.787284837503016,"1.0,0.0","1.0,0.144",-0.072]
[210,"ENSG00000160298.17","C21orf58","chr21","-",46301129,46302154,46301129,46301713,46301996,46302154,210,475488,"72,35",530510,"17,19",298,149,{"v":7.01220901456e-07,"d":"7.01E-07"},{"v":3.09227990465494e-06,"d":"3.09E-06"},"0.767,0.875","0.94,0.931",-0.115]
[211,"ENSG00000160298.17","C21orf58","chr21","-",46314870,46315547,46314870,46315049,46315473,46315547,211,"55,63","56,69",142185,"31,58",298,149,{"v":3.09761105655e-11,"d":"3.10E-11"},{"v":2.17107303741946E-10,"d":"2.17E-10"},"0.329,0.313","0.696,0.615",-0.334]
[212,"ENSG00000160294.10","MCM3AP","chr21","-",46246306,46246886,46246306,46246404,46246627,46246886,212,221252,348389,369341,334393,298,149,0.000910661487288,2.48053315567253E-3,"0.241,0.245","0.356,0.303",-0.087]
[213,"ENSG00000160285.14","LSS","chr21","-",46188445,46191235,46188445,46188821,46191075,46191235,213,138101,"0,0","69,66","1,0",298,149,1,1,"1.0,1.0","0.972,1.0",0.014]
[214,"ENSG00000160285.14","LSS","chr21","-",46228433,46228824,46228433,46228599,46228731,46228824,214,"7,10",272242,"11,14","97,99",281,149,{"v":8.3433656529e-05,"d":"8.34E-05"},0.000268219986605762,"0.013,0.021","0.057,0.07",-0.046]
[215,"ENSG00000160226.15","CFAP410","chr21","-",44330462,44332014,44330462,44330916,44331842,44332014,215,"44,43","22,34",108150,"7,36",298,149,{"v":2.9339385158e-05,"d":"2.93E-05"},1.01395034650189E-4,"0.5,0.387","0.885,0.676",-0.337]
[216,"ENSG00000141959.16","PFKL","chr21","+",44313912,44316339,44313912,44314021,44316243,44316339,216,118161,728808,163172,491528,298,149,{"v":9.30238685026e-06,"d":"9.30E-06"},{"v":3.51133370335027e-05,"d":"3.51E-05"},"0.075,0.091","0.142,0.14",-0.058]
[217,"ENSG00000141959.16","PFKL","chr21","+",44319350,44320147,44319350,44319415,44320083,44320147,217,207241,11981255,416471,687658,298,149,0,0,"0.08,0.088","0.232,0.264",-0.164]
[218,"ENSG00000141959.16","PFKL","chr21","+",44319350,44321875,44319350,44320147,44321728,44321875,218,"39,47",15281690,"95,96",872911,298,149,0,0,"0.013,0.014","0.052,0.05",-0.038]
[219,"ENSG00000141959.16","PFKL","chr21","+",44324855,44326060,44324855,44324917,44325960,44326060,219,230226,"2,2",302287,"18,15",298,149,{"v":3.66704734489E-6,"d":"3.67E-06"},{"v":1.46836621531671E-5,"d":"1.47E-05"},"0.983,0.983","0.893,0.905",0.084]
[223,"ENSG00000160221.17","GATD3A","chr21","+",44144820,44145723,44144820,44144916,44145570,44145723,223,261278,"7,1",196208,"4,0",298,149,0.369620766943,0.527473846359258,"0.949,0.993","0.961,1.0",-0.009]
[224,"ENSG00000160201.11","U2AF1","chr21","-",43092955,43094563,43092955,43093249,43094470,43094563,224,"44,34","0,3","93,66","0,0",298,149,0.387420570552,0.546653649433736,"1.0,0.85","1.0,1.0",-0.075]
[225,"ENSG00000160201.11","U2AF1","chr21","-",43100452,43104402,43100452,43100519,43104314,43104402,225,"0,0","29,20","2,0","6,10",298,149,0.848735561293,0.997337850008738,"0.0,0.0","0.143,0.0",-0.071]
[228,"ENSG00000173276.13","ZBTB21","chr21","-",41986830,41994108,41986830,41991889,41992492,41994108,228,101106,"11,9",168174,"17,7",298,149,0.381352114095,0.540315252726418,"0.821,0.855","0.832,0.926",-0.041]
[230,"ENSG00000157601.13","MX1","chr21","+",41421837,41422095,41421837,41421871,41421974,41422095,230,"6,2","0,0","2,2","4,0",252,149,0.00644490676476,0.0151092305329971,"1.0,1.0","0.228,1.0",0.386]
[232,"ENSG00000156256.14","USP16","chr21","+",29042471,29043599,29042471,29042528,29043422,29043599,232,"85,96",494407,706650,228222,298,149,0,0,"0.079,0.105","0.608,0.594",-0.509]
[233,"ENSG00000156253.6","RWDD2B","chr21","-",29008239,29008621,29008239,29008307,29008394,29008621,233,"47,49",185178,"31,21","3,7",236,149,{"v":6.55031584529E-14,"d":"6.55E-14"},{"v":5.82045855541218e-13,"d":"5.82E-13"},"0.138,0.148","0.867,0.654",-0.617]
[234,"ENSG00000156239.11","N6AMT1","chr21","-",28872190,28876491,28872190,28872739,28876311,28876491,234,"101,78","55,53",226226,"19,12",298,149,0,0,"0.479,0.424","0.856,0.904",-0.428]
[235,"ENSG00000012211.12","PRICKLE3","chrX","-",49177992,49178475,49177992,49178179,49178271,49178475,235,"4,14","53,82","30,40",77123,241,149,0.000381873541508,1.10960805539219E-3,"0.045,0.095","0.194,0.167",-0.11]
[239,"ENSG00000198034.10","RPS4X","chrX","-",72273800,72275150,72273800,72273972,72275052,72275150,239,207258,2137421004,313310,2412126199,298,149,1,1,"0.005,0.006","0.006,0.006",-1E-3]
[240,"ENSG00000275464.4","FP565260.1","chr21","-",5135934,5137474,5135934,5136043,5137326,5137474,240,"23,20",787714,"10,13",474555,298,149,0.325725525367,0.475266795161874,"0.014,0.014","0.01,0.012",0.003]
[241,"ENSG00000275464.4","FP565260.1","chr21","-",5139697,5141103,5139697,5139878,5140952,5141103,241,"14,2",325292,"10,18",181223,298,149,0.00251671484295,6.37576718088507E-3,"0.021,0.003","0.027,0.039",-0.021]
[242,"ENSG00000198276.15","UCKL1","chr20","-",63940949,63941208,63940949,63941043,63941109,63941208,242,"62,76",193162,"37,61",141134,215,149,0.608530012571,0.776411645509382,"0.182,0.245","0.154,0.24",0.016]
[243,"ENSG00000198276.15","UCKL1","chr20","-",63945804,63946267,63945804,63945975,63946160,63946267,243,"82,90",309313,163167,180142,298,149,0,0,"0.117,0.126","0.312,0.37",-0.219]
[244,"ENSG00000203896.9","LIME1","chr20","+",63737820,63738060,63737820,63737902,63737972,63738060,244,"12,16","7,13","26,42","14,29",219,149,0.745672474823,0.907002279680885,"0.538,0.456","0.558,0.496",-0.03]
[245,"ENSG00000203896.9","LIME1","chr20","+",63737820,63738060,63737820,63737902,63738007,63738060,245,"21,24","28,35","37,71","60,47",254,149,0.323950911036,0.473551162312328,"0.306,0.287","0.266,0.47",-0.072]
[246,"ENSG00000203896.9","LIME1","chr20","+",63738007,63738499,63738007,63738060,63738182,63738499,246,"9,10","44,64","27,29",64111,271,149,0.0296393140218,0.0590670075738937,"0.101,0.079","0.188,0.126",-0.067]
[247,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63734824,63733586,63733712,63734644,63734824,247,106126,"0,4",112110,"0,1",298,149,0.542850735129,0.715031437362,"1.0,0.94","1.0,0.982",-0.021]
[248,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63734824,63733586,63733739,63734644,63734824,248,"67,90","2,17","65,71","7,9",298,149,0.851534312314,0.999389144677202,"0.944,0.726","0.823,0.798",0.024]
[249,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63734824,63733586,63733775,63734644,63734824,249,"72,91","0,0","71,77","2,0",298,149,0.447479055609,0.614695589729827,"1.0,1.0","0.947,1.0",0.026]
[250,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63734824,63733586,63733712,63734704,63734824,250,119141,"14,14",114118,"13,10",298,149,0.771474723167,0.92765557826332,"0.81,0.834","0.814,0.855",-0.012]
[251,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63734824,63733586,63733739,63734704,63734824,251,80105,"85,81","67,79","106,85",298,149,0.0534870790589,0.0991778781299259,"0.32,0.393","0.24,0.317",0.078]
[252,"ENSG00000101246.19","ARFRP1","chr20","-",63698642,63700702,63698642,63700530,63700601,63700702,252,59100,281393,219212,153224,220,149,0,0,"0.124,0.147","0.492,0.391",-0.306]
[253,"ENSG00000026036.22","RTEL1-TNFRSF6B","chr20","+",63688527,63689132,63688527,63688605,63689054,63689132,253,"74,67",176168,"17,23",118121,298,149,{"v":1.83647197276E-5,"d":"1.84E-05"},{"v":6.62162576804422e-05,"d":"6.62E-05"},"0.174,0.166","0.067,0.087",0.093]
[254,"ENSG00000026036.22","RTEL1-TNFRSF6B","chr20","+",63689749,63690210,63689749,63689865,63690086,63690210,254,"49,48",154215,"23,31",124130,298,149,0.274558292511,0.411490555263643,"0.137,0.1","0.085,0.107",0.023]
[255,"ENSG00000026036.22","RTEL1-TNFRSF6B","chr20","+",63691741,63693003,63691741,63691837,63692804,63693003,255,"18,21",217261,"22,20",135135,298,149,0.013113603365,0.0287674747882223,"0.04,0.039","0.075,0.069",-0.033]
[256,"ENSG00000026036.22","RTEL1-TNFRSF6B","chr20","+",63695777,63697191,63695777,63695854,63696759,63697191,256,199151,"17,4",134148,"3,3",298,149,0.0112920753976,0.0251908311056003,"0.854,0.95","0.957,0.961",-0.057]
[257,"ENSG00000101203.16","COL20A1","chr20","+",63319057,63319596,63319057,63319200,63319486,63319596,257,"0,1","1,0","0,0","3,0",298,149,1,1,"0.0,1.0","0.0,NA",0.5]
[261,"ENSG00000101194.17","SLC17A9","chr20","+",62962623,62963369,62962623,62962734,62963272,62963369,261,590575,"17,14",177173,"8,8",298,149,0.173272795853,0.278139180082031,"0.946,0.954","0.917,0.915",0.034]
[262,"ENSG00000101194.17","SLC17A9","chr20","+",62962623,62963369,62962623,62962754,62963272,62963369,262,629615,219202,190184,"43,61",298,149,0.235461946166,0.360874332867464,"0.59,0.604","0.688,0.601",-0.047]
[263,"ENSG00000101194.17","SLC17A9","chr20","+",62966702,62968597,62966702,62966732,62967336,62968597,263,217219,184169,114106,83109,298,149,0.657113681722,0.822041766351407,"0.371,0.393","0.407,0.327",0.015]
[264,"ENSG00000171858.17","RPS21","chr20","+",62388308,62388519,62388308,62388364,62388456,62388519,264,779740,1320211576,14781667,1227313730,241,149,{"v":1.25534693751e-10,"d":"1.26E-10"},{"v":8.27308502567354e-10,"d":"8.27E-10"},"0.035,0.038","0.069,0.07",-0.033]
[265,"ENSG00000130703.16","OSBPL2","chr20","+",62281057,62281879,62281057,62281165,62281789,62281879,265,"31,36",142136,"42,42",111163,298,149,0.233178479924,0.358068571922129,"0.098,0.117","0.159,0.114",-0.029]
[266,"ENSG00000101158.13","NELFCD","chr20","+",58988913,58989640,58988913,58989021,58989487,58989640,266,188144,759723,161147,334334,298,149,{"v":1.00457903218E-7,"d":"1.00E-07"},{"v":4.90909115107528e-07,"d":"4.91E-07"},"0.11,0.091","0.194,0.18",-0.086]
[267,"ENSG00000101158.13","NELFCD","chr20","+",58992997,58993544,58992997,58993112,58993448,58993544,267,"37,51",793776,134119,285344,298,149,0,0,"0.023,0.032","0.19,0.147",-0.141]
[268,"ENSG00000101158.13","NELFCD","chr20","+",58993623,58994239,58993623,58993675,58994109,58994239,268,565548,"65,45",287311,56109,298,149,{"v":2.04960263928e-06,"d":"2.05E-06"},{"v":8.4937681426931e-06,"d":"8.49E-06"},"0.813,0.859","0.719,0.588",0.182]
[269,"ENSG00000101158.13","NELFCD","chr20","+",58993623,58994239,58993623,58993764,58994109,58994239,269,513485,610583,253296,183199,298,149,{"v":2.33149652425E-5,"d":"2.33E-05"},{"v":8.24362966286605e-05,"d":"8.24E-05"},"0.296,0.294","0.409,0.427",-0.123]
[270,"ENSG00000101158.13","NELFCD","chr20","+",58994641,58995133,58994641,58994824,58994925,58995133,270,15691556,"52,54",657751,"18,29",250,149,0.849535889543,0.99753719274475,"0.947,0.945","0.956,0.939",-2E-3]
[271,"ENSG00000087460.24","GNAS","chr20","+",58909349,58909579,58909349,58909423,58909520,58909579,271,"60,63",86978724,"57,57",85268493,246,149,1,1,"0.004,0.004","0.004,0.004",0]
[272,"ENSG00000215440.11","NPEPL1","chr20","+",58713419,58714093,58713419,58713543,58713916,58714093,272,"69,55",108118,"37,35",105110,298,149,0.0128376583269,0.0282012447968243,"0.242,0.189","0.15,0.137",0.072]
[273,"ENSG00000124222.22","STX16","chr20","+",58651271,58652087,58651271,58651414,58652072,58652087,273,689632,"2,0",11551138,"9,4",298,149,0.911183815251,1,"0.994,1.0","0.985,0.993",0.008]
[274,"ENSG00000124222.22","STX16","chr20","+",58651282,58652138,58651282,58651434,58652072,58652138,274,710655,"0,7",11851182,"25,25",298,149,{"v":2.39871696327e-05,"d":"2.40E-05"},{"v":8.46238809718672e-05,"d":"8.46E-05"},"1.0,0.979","0.96,0.959",0.03]
[275,"ENSG00000124224.16","PPP4R1L","chr20","-",58245782,58247506,58245782,58246252,58247321,58247506,275,"6,10","6,7","14,12","21,21",298,149,0.160195915369,0.260051186597983,"0.333,0.417","0.25,0.222",0.139]
[277,"ENSG00000124228.14","DDX27","chr20","+",49233567,49236231,49233567,49233709,49236149,49236231,277,"55,46","0,0",140114,"0,2",298,149,1,1,"1.0,1.0","1.0,0.966",0.017]
[278,"ENSG00000124228.14","DDX27","chr20","+",49243628,49244077,49243628,49243703,49243815,49244077,278,"30,23",337305,"24,21",320321,261,149,0.483324143757,0.653941563195598,"0.048,0.041","0.041,0.036",0.006]
[279,"ENSG00000062598.17","ELMO2","chr20","-",46368890,46370525,46368890,46368968,46370442,46370525,279,"12,16",186176,"32,33",195165,298,149,0.00051649450883,1.46840410089775E-3,"0.031,0.043","0.076,0.091",-0.046]
[280,"ENSG00000080189.14","SLC35C2","chr20","-",46349527,46350890,46349527,46350524,46350760,46350890,280,"73,89",249330,"67,87",174250,298,149,0.113240962964,0.191766013299136,"0.128,0.119","0.161,0.148",-0.031]
[281,"ENSG00000080189.14","SLC35C2","chr20","-",46358386,46358763,46358386,46358558,46358690,46358763,281,395404,"0,1",376414,"6,1",281,149,0.841459694755,0.990996835843255,"1.0,0.995","0.971,0.995",0.015]
[282,"ENSG00000166913.12","YWHAB","chr20","+",44901530,44904116,44901530,44901833,44903992,44904116,282,119101,25742285,"88,89",20732182,298,149,0.572936070762,0.740861190460494,"0.023,0.022","0.021,0.02",2E-3]
[283,"ENSG00000166913.12","YWHAB","chr20","+",44904967,44906096,44904967,44905131,44906000,44906096,283,137108,45943709,169105,29593043,298,149,0.00165317472147,0.00432909164093551,"0.015,0.014","0.028,0.017",-0.008]
[284,"ENSG00000196756.11","SNHG17","chr20","-",38421005,38422241,38421005,38421098,38422091,38422241,284,125102,"53,41","27,38","17,12",298,149,0.814760128782,0.96675089049027,"0.541,0.554","0.443,0.613",0.02]
[285,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771193,36770872,36770974,36771114,36771193,285,813666,"6,0",609682,"2,2",289,149,1,1,"0.986,1.0","0.994,0.994",-1E-3]
[286,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771473,36770872,36770977,36771424,36771473,286,507373,"10,13",484539,"10,8",298,149,0.224705468001,0.346740632736502,"0.962,0.935","0.96,0.971",-0.017]
[287,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771473,36770872,36771024,36771424,36771473,287,430376,"2,13",461478,"3,0",298,149,0.00255173204556,0.00645414102141908,"0.991,0.935","0.987,1.0",-0.03]
[288,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771473,36770872,36771193,36771424,36771473,288,108108,204155,325333,"96,69",298,149,0,0,"0.209,0.258","0.629,0.707",-0.434]
[289,"ENSG00000061656.9","SPAG4","chr20","+",35617519,35617840,35617519,35617586,35617778,35617840,289,"4,9","8,7","4,2","0,0",298,149,{"v":7.24889857695e-07,"d":"7.25E-07"},{"v":3.18776865130933e-06,"d":"3.19E-06"},"0.2,0.391","1.0,1.0",-0.705]
[290,"ENSG00000061656.9","SPAG4","chr20","+",35618449,35618720,35618449,35618475,35618611,35618720,290,"26,16","17,7","14,7","1,0",285,149,{"v":9.46651171119e-06,"d":"9.47E-06"},{"v":3.56214100472613e-05,"d":"3.56E-05"},"0.444,0.544","0.88,1.0",-0.446]
[298,"ENSG00000100983.10","GSS","chr20","-",34942487,34943006,34942487,34942627,34942930,34943006,298,127114,643553,"18,14","53,32",298,149,0.0239547600245,0.0489093529760122,"0.09,0.093","0.145,0.179",-0.07]
[300,"ENSG00000101444.12","AHCY","chr20","-",34290331,34290638,34290331,34290449,34290550,34290638,300,"79,96",22072509,"38,75",16501845,250,149,0.350389606859,0.505195589348512,"0.021,0.022","0.014,0.024",2E-3]
[302,"ENSG00000125967.16","NECAB3","chr20","-",33659496,33659732,33659496,33659550,33659652,33659732,302,"14,18","32,18","25,14","9,16",251,149,0.0743345851252,0.132650472515635,"0.206,0.372","0.622,0.342",-0.193]
[303,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660395,33659884,33659998,33660258,33660395,303,"42,26","1,2","20,10","0,0",298,149,0.425286035872,0.589363972024719,"0.955,0.867","1.0,1.0",-0.089]
[304,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660395,33659884,33660003,33660258,33660395,304,"42,26","28,49","17,13","19,17",298,149,0.833999975847,0.984655358396122,"0.429,0.21","0.309,0.277",0.026]
[306,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660395,33659884,33660058,33660258,33660395,306,"53,29","3,0","20,20","0,1",298,149,0.363787071594,0.521659007166373,"0.898,1.0","1.0,0.909",-0.005]
[307,"ENSG00000125967.16","NECAB3","chr20","-",33669374,33669712,33669374,33669472,33669686,33669712,307,"22,12","61,56","8,7","25,63",298,149,0.108924403377,0.185607876512908,"0.153,0.097","0.138,0.053",0.029]
[309,"ENSG00000149600.11","COMMD7","chr20","-",32702702,32704071,32702702,32703458,32704022,32704071,309,107108,12471104,357410,610634,298,149,0,0,"0.041,0.047","0.226,0.244",-0.191]
[310,"ENSG00000171456.18","ASXL1","chr20","+",32428127,32428422,32428127,32428248,32428324,32428422,310,"67,51",366394,"40,62",478484,225,149,0.0281925128939,0.0566117112490713,"0.108,0.079","0.053,0.078",0.028]
[311,"ENSG00000022277.12","RTF2","chr20","+",56516934,56517201,56516934,56516989,56517105,56517201,311,"50,31",13691157,"37,52",716786,265,149,0.00108382221406,0.00291043373271912,"0.02,0.015","0.028,0.036",-0.014]
[314,"ENSG00000132640.14","BTBD3","chr20","+",11917777,11918601,11917777,11918011,11918333,11918601,314,"16,12","3,10","31,23","8,3",298,149,0.196282755845,0.309422483881901,"0.727,0.375","0.66,0.793",-0.176]
[315,"ENSG00000101384.12","JAG1","chr20","-",10648548,10649107,10648548,10648676,10649060,10649107,315,"19,18","3,2","16,10","0,0",298,149,0.0013805177763,3.65340593895343E-3,"0.76,0.818","1.0,1.0",-0.211]
[316,"ENSG00000101384.12","JAG1","chr20","-",10648548,10649107,10648548,10648722,10649060,10649107,316,"4,1","40,49","3,10","47,57",298,149,0.0773185618757,0.137355513328415,"0.048,0.01","0.031,0.081",-0.027]
[317,"ENSG00000101384.12","JAG1","chr20","-",10650246,10651694,10650246,10650360,10651580,10651694,317,"5,6","44,27","5,6","43,64",298,149,0.418159914171,0.581376591267197,"0.054,0.1","0.055,0.045",0.027]
[318,"ENSG00000089195.14","TRMT6","chr20","-",5941052,5942036,5941052,5941139,5941950,5942036,318,"83,59","0,1","40,19","0,1",298,149,1,1,"1.0,0.967","1.0,0.905",0.031]
[320,"ENSG00000101222.12","SPEF1","chr20","-",3778745,3778990,3778745,3778806,3778950,3778990,320,"0,0","2,0","4,0","0,0",293,149,1,1,"0.0,NA","1.0,NA",-1]
[324,"ENSG00000215305.9","VPS16","chr20","+",2863948,2864287,2863948,2864083,2864178,2864287,324,"68,68",267230,"29,31",148128,244,149,0.214680483275,0.333549080923338,"0.135,0.153","0.107,0.129",0.026]
[327,"ENSG00000088832.16","FKBP1A","chr20","-",1368977,1370072,1368977,1369039,1369771,1370072,327,43014477,"7,14",14591427,"2,2",298,149,1,1,"0.997,0.994","0.997,0.997",-1E-3]
[328,"ENSG00000101266.18","CSNK2A1","chr20","-",486375,487575,486375,486462,487426,487575,328,"8,13",23102227,"19,38",23942434,298,149,1,1,"0.002,0.003","0.004,0.008",-0.004]
[329,"ENSG00000101266.18","CSNK2A1","chr20","-",487426,488778,487426,487575,488677,488778,329,"25,19",35182953,"37,46",27912885,298,149,1,1,"0.004,0.003","0.007,0.008",-0.004]
[330,"ENSG00000101266.18","CSNK2A1","chr20","-",499254,499934,499254,499305,499832,499934,330,"14,35",22852145,"30,45",20542026,298,149,0.954913726724,1,"0.003,0.008","0.007,0.011",-0.003]
[331,"ENSG00000125875.13","TBC1D20","chr20","-",435479,438841,435479,435970,438549,438841,331,281245,"0,2",404381,"0,0",298,149,1,1,"1.0,0.984","1.0,1.0",-0.008]
[332,"ENSG00000125875.13","TBC1D20","chr20","-",441587,442043,441587,441689,441856,442043,332,"50,63",187207,"90,94",201239,298,149,0.0236072666853,0.0483246248583902,"0.118,0.132","0.183,0.164",-0.048]
[333,"ENSG00000099326.8","MZF1","chr19","-",58570343,58571429,58570343,58570527,58570993,58571429,333,143156,"44,34",260252,"77,75",298,149,0.484635892044,0.655529449187223,"0.619,0.696","0.628,0.627",0.03]
[334,"ENSG00000130726.11","TRIM28","chr19","+",58548739,58548910,58548739,58548776,58548861,58548910,334,505538,61206283,334367,47874907,234,149,0.180982840023,0.289340827462646,"0.05,0.052","0.043,0.045",0.007]
[335,"ENSG00000130726.11","TRIM28","chr19","+",58548739,58548910,58548739,58548776,58548885,58548910,335,29293006,"11,23",21632197,"13,35",258,149,0.0107112760433,0.0240307351420607,"0.994,0.987","0.99,0.973",0.009]
[336,"ENSG00000130726.11","TRIM28","chr19","+",58549736,58550035,58549736,58549860,58549948,58550035,336,165185,957410173,295306,70477680,237,149,{"v":5.63527002839e-12,"d":"5.64E-12"},{"v":4.19112167471952e-11,"d":"4.19E-11"},"0.011,0.011","0.026,0.024",-0.014]
[337,"ENSG00000083838.15","ZNF446","chr19","+",58479642,58480019,58479642,58479727,58479929,58480019,337,"31,11","15,17","24,19","22,35",298,149,0.307295328912,0.452971834634184,"0.508,0.244","0.353,0.213",0.093]
[342,"ENSG00000083844.10","ZNF264","chr19","+",57191500,57191946,57191500,57191527,57191698,57191946,342,"62,50","0,4",118175,"0,0",298,149,0.130294898501,0.216473842222424,"1.0,0.862","1.0,1.0",-0.069]
[344,"ENSG00000108107.14","RPL28","chr19","+",55386569,55388048,55386569,55386674,55387929,55388048,344,44644097,"21,19",52985836,"29,25",298,149,1,1,"0.991,0.991","0.989,0.992",1E-3]
[345,"ENSG00000108107.14","RPL28","chr19","+",55386569,55388048,55386569,55386693,55387929,55388048,345,241279,5180152526,9691030,4797349200,298,149,0.946020691436,1,"0.002,0.003","0.01,0.01",-0.007]
[347,"ENSG00000131037.14","EPS8L1","chr19","+",55082091,55082349,55082091,55082180,55082274,55082349,347,"12,2","31,79","15,12","28,36",243,149,0.00501644557504,0.0120217344714973,"0.192,0.015","0.247,0.17",-0.105]
[348,"ENSG00000131037.14","EPS8L1","chr19","+",55083377,55083644,55083377,55083519,55083615,55083644,348,"26,8","63,71","2,4","32,30",245,149,0.0159827308232,0.034145906238669,"0.201,0.064","0.037,0.075",0.077]
[349,"ENSG00000022556.15","NLRP2","chr19","+",54969998,54970295,54969998,54970153,54970222,54970295,349,450441,"4,5",350358,"3,3",218,149,0.668158091889,0.833003191280427,"0.987,0.984","0.988,0.988",-2E-3]
[350,"ENSG00000022556.15","NLRP2","chr19","+",54990021,54990393,54990021,54990096,54990214,54990393,350,350307,"11,8",290239,"1,0",267,149,1.02782289661E-4,0.000326003986926099,"0.947,0.955","0.994,1.0",-0.046]
[354,"ENSG00000170889.13","RPS9","chr19","+",54206275,54206724,54206275,54206462,54206552,54206724,354,"55,42",160168,"52,50",443492,239,149,{"v":1.05616917545e-07,"d":"1.06E-07"},{"v":5.15588759003112e-07,"d":"5.16E-07"},"0.176,0.135","0.068,0.06",0.091]
[355,"ENSG00000170889.13","RPS9","chr19","+",54206552,54207647,54206552,54206724,54207397,54207647,355,"9,21",238267,"33,29",488505,298,149,0.738486354531,0.900338579714695,"0.019,0.038","0.033,0.028",-2E-3]
[357,"ENSG00000170949.17","ZNF160","chr19","-",53091412,53091720,53091412,53091497,53091636,53091720,357,"32,51","5,0","40,54","0,0",288,149,0.0127778592598,0.0280828819767258,"0.768,1.0","1.0,1.0",-0.116]
[358,"ENSG00000170949.17","ZNF160","chr19","-",53091412,53091720,53091412,53091529,53091636,53091720,358,"23,50","21,9","37,51","10,14",256,149,0.407034534883,0.569728279651868,"0.389,0.764","0.683,0.68",-0.105]
[359,"ENSG00000170949.17","ZNF160","chr19","-",53091412,53091720,53091412,53091553,53091636,53091720,359,"22,48","7,3","36,48","9,6",232,149,0.672927458668,0.836750731493621,"0.669,0.911","0.72,0.837",0.012]
[360,"ENSG00000161551.14","ZNF577","chr19","-",51886820,51887936,51886820,51886912,51887831,51887936,360,183156,"4,4",224181,"6,2",298,149,0.765419556987,0.922742834833159,"0.958,0.951","0.949,0.978",-0.009]
[361,"ENSG00000161551.14","ZNF577","chr19","-",51886820,51887951,51886820,51886912,51887895,51887951,361,155133,"4,14",183156,"16,7",298,149,0.813912052929,0.965986165869961,"0.951,0.826","0.851,0.918",0.004]
[363,"ENSG00000142512.14","SIGLEC10","chr19","-",51415897,51416357,51415897,51416167,51416309,51416357,363,"42,41",222249,"29,38",191215,291,149,0.724574753226,0.887482499756677,"0.088,0.078","0.072,0.083",0.005]
[369,"ENSG00000167748.10","KLK1","chr19","-",50819898,50820443,50819898,50820035,50820153,50820443,369,"2,5","6,15","0,2","12,20",267,149,0.00883184184017,0.0202645500636395,"0.157,0.157","0.0,0.053",0.131]
[370,"ENSG00000062822.13","POLD1","chr19","+",50401998,50402373,50401998,50402124,50402204,50402373,370,171164,541573,72109,539574,229,149,{"v":1.08439219922E-5,"d":"1.08E-05"},{"v":4.04515800731045e-05,"d":"4.05E-05"},"0.171,0.157","0.08,0.11",0.069]
[371,"ENSG00000062822.13","POLD1","chr19","+",50415723,50416528,50415723,50415826,50416395,50416528,371,272249,1023987,411511,609678,298,149,0,0,"0.117,0.112","0.252,0.274",-0.149]
[372,"ENSG00000131400.7","NAPSA","chr19","-",50361662,50362313,50361662,50361781,50362171,50362313,372,"5,1","0,0","6,2","0,2",298,149,0.301645903788,0.44505902160263,"1.0,1.0","1.0,0.333",0.334]
[373,"ENSG00000131408.13","NR1H2","chr19","+",50376472,50376826,50376472,50376576,50376718,50376826,373,"5,15",218275,"7,18",297351,291,149,0.959727566446,1,"0.012,0.027","0.012,0.026",1E-3]
[377,"ENSG00000126460.10","PRRG2","chr19","+",49583206,49583717,49583206,49583304,49583541,49583717,377,"0,0","5,2","2,2","3,4",298,149,0.00481588190635,0.0115820373267261,"0.0,0.0","0.25,0.2",-0.225]
[378,"ENSG00000104870.12","FCGRT","chr19","+",49513881,49514486,49513881,49514133,49514210,49514486,378,"7,12",175168,"60,70",168189,226,149,{"v":2.99760216649e-15,"d":"3.00E-15"},{"v":2.95095897925208E-14,"d":"2.95E-14"},"0.026,0.045","0.191,0.196",-0.158]
[379,"ENSG00000104870.12","FCGRT","chr19","+",49524506,49525573,49524506,49524776,49525456,49525573,379,"70,70",321357,228220,310277,298,149,0,0,"0.098,0.089","0.269,0.284",-0.183]
[380,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490297,49489849,49489922,49490126,49490297,380,581614,"0,1",745776,"3,2",298,149,1,1,"1.0,0.997","0.992,0.995",0.005]
[381,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490297,49489849,49489912,49490231,49490297,381,668676,341293,787837,12931606,298,149,0,0,"0.495,0.536","0.233,0.207",0.296]
[382,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490297,49489849,49489922,49490231,49490297,382,624627,5914261613,761792,8004591880,298,149,1,1,"0.005,0.005","0.005,0.004",0]
[383,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490297,49489849,49490090,49490231,49490297,383,676661,"0,2",814904,"8,8",290,149,0.146632987531,0.240253289307525,"1.0,0.994","0.981,0.983",0.015]
[384,"ENSG00000142541.16","RPL13A","chr19","+",49490231,49490576,49490231,49490297,49490474,49490576,384,559541,7250473147,781841,101058113415,298,149,1,1,"0.004,0.004","0.004,0.004",0]
[385,"ENSG00000142541.16","RPL13A","chr19","+",49490778,49491099,49490778,49490864,49491039,49491099,385,807755,6855168200,615605,7651779106,298,149,1,1,"0.006,0.006","0.004,0.004",2E-3]
[387,"ENSG00000142541.16","RPL13A","chr19","+",49491039,49491547,49491039,49491099,49491424,49491547,387,353279,7987979609,273231,8569690152,298,149,1,1,"0.002,0.002","0.002,0.001",1E-3]
[388,"ENSG00000104872.10","PIH1D1","chr19","-",49447826,49448010,49447826,49447908,49448000,49448010,388,187137,10261075,141130,251250,241,149,0,0,"0.101,0.073","0.258,0.243",-0.164]
[389,"ENSG00000104894.11","CD37","chr19","+",49335713,49337033,49335713,49335782,49336908,49337033,389,"83,69","56,34","31,21","60,67",298,149,{"v":1.03224373493E-9,"d":"1.03E-09"},{"v":6.13015835074198e-09,"d":"6.13E-09"},"0.426,0.504","0.205,0.135",0.295]
[390,"ENSG00000104894.11","CD37","chr19","+",49335713,49337033,49335713,49335786,49336908,49337033,390,"73,62",713693,"24,11",832851,298,149,{"v":2.68673971959e-14,"d":"2.69E-14"},{"v":2.45637378987563e-13,"d":"2.46E-13"},"0.049,0.043","0.014,0.006",0.036]
[391,"ENSG00000104894.11","CD37","chr19","+",49339329,49340606,49339329,49339413,49340250,49340606,391,408492,566594,275274,868884,298,149,{"v":4.10782519111e-14,"d":"4.11E-14"},{"v":3.71269152986989e-13,"d":"3.71E-13"},"0.265,0.293","0.137,0.134",0.144]
[392,"ENSG00000130529.15","TRPM4","chr19","+",49188640,49189091,49188640,49188770,49188945,49189091,392,"0,6","8,2","11,1","0,0",298,149,{"v":2.9092531717E-8,"d":"2.91E-08"},{"v":1.51696772524357E-7,"d":"1.52E-07"},"0.0,0.6","1.0,1.0",-0.7]
[393,"ENSG00000130529.15","TRPM4","chr19","+",49211163,49211834,49211163,49211269,49211493,49211834,393,"12,11",221237,"41,60",251279,298,149,{"v":1.49871535182E-8,"d":"1.50E-08"},{"v":8.03548513489932e-08,"d":"8.04E-08"},"0.026,0.023","0.076,0.097",-0.062]
[394,"ENSG00000104805.15","NUCB1","chr19","+",48919029,48919286,48919029,48919122,48919193,48919286,394,"43,73",11841041,"35,28",725852,220,149,0.145868168204,0.239165327618514,"0.024,0.045","0.032,0.022",0.008]
[395,"ENSG00000174951.11","FUT1","chr19","-",48752489,48753122,48752489,48752725,48752891,48753122,395,"51,58","12,18",92124,"15,13",298,149,0.0146352885774,0.0315943786623125,"0.68,0.617","0.754,0.827",-0.142]
[396,"ENSG00000174951.11","FUT1","chr19","-",48753324,48753660,48753324,48753563,48753647,48753660,396,"37,25","0,7","49,80","2,2",233,149,0.0953223211986,0.165315940821402,"1.0,0.695","0.94,0.962",-0.104]
[398,"ENSG00000105443.14","CYTH2","chr19","+",48474837,48478145,48474837,48474949,48478068,48478145,398,"77,63",214215,130125,"31,47",298,149,0,0,"0.152,0.128","0.677,0.571",-0.484]
[400,"ENSG00000105483.17","CARD8","chr19","-",48232452,48234543,48232452,48232493,48234402,48234543,400,245292,258152,230182,410436,298,149,{"v":3.42835202649E-6,"d":"3.43E-06"},{"v":1.37510823040532E-5,"d":"1.38E-05"},"0.322,0.49","0.219,0.173",0.21]
[401,"ENSG00000105483.17","CARD8","chr19","-",48232452,48234543,48232452,48232789,48234402,48234543,401,252259,"3,0",217175,"0,0",298,149,1,1,"0.977,1.0","1.0,1.0",-0.012]
[404,"ENSG00000105373.18","NOP53","chr19","+",47755755,47756604,47755755,47755822,47756527,47756604,404,179159,18901859,256356,28332927,298,149,0.199739204755,0.314349096703971,"0.045,0.041","0.043,0.057",-0.007]
[405,"ENSG00000105402.7","NAPA","chr19","-",47492014,47493493,47492014,47492119,47493415,47493493,405,"45,53","0,4",207160,"1,0",298,149,0.10633626843,0.181694488188818,"1.0,0.869","0.99,1.0",-0.06]
[406,"ENSG00000160007.18","ARHGAP35","chr19","+",46987988,46989675,46987988,46988066,46989543,46989675,406,"6,8",205238,"9,5",103126,298,149,0.127822041857,0.213186498633203,"0.014,0.017","0.042,0.019",-0.015]
[407,"ENSG00000090372.14","STRN4","chr19","-",46721985,46722340,46721985,46722072,46722241,46722340,407,"45,54",10391083,70103,508563,298,149,{"v":3.34177130412e-14,"d":"3.34E-14"},{"v":3.043513404616E-13,"d":"3.04E-13"},"0.021,0.024","0.064,0.084",-0.052]
[408,"ENSG00000125755.18","SYMPK","chr19","-",45827836,45829205,45827836,45827918,45828969,45829205,408,105102,697691,132133,520467,298,149,{"v":3.52665291347e-05,"d":"3.53E-05"},1.20474932141217E-4,"0.07,0.069","0.113,0.125",-0.049]
[409,"ENSG00000125755.18","SYMPK","chr19","-",45827836,45829205,45827836,45827918,45829054,45829205,409,358387,"6,11",403292,"4,9",298,149,0.574129291274,0.741260119510315,"0.968,0.946","0.981,0.942",-0.005]
[410,"ENSG00000125755.18","SYMPK","chr19","-",45854174,45854507,45854174,45854240,45854390,45854507,410,"23,17",585610,"10,25",624648,298,149,0.443379391159,0.609984114540288,"0.019,0.014","0.008,0.019",0.003]
[412,"ENSG00000104884.15","ERCC2","chr19","-",45368929,45369147,45368929,45368992,45369069,45369147,412,"5,8",380386,"14,29","103,95",226,149,{"v":6.66133814775e-16,"d":"6.66E-16"},{"v":6.87131511110298e-15,"d":"6.87E-15"},"0.009,0.013","0.082,0.168",-0.114]
[413,"ENSG00000104856.13","RELB","chr19","+",45034243,45034528,45034243,45034312,45034450,45034528,413,"4,2","27,22","1,2","23,35",287,149,0.152734899271,0.249132725005464,"0.071,0.045","0.022,0.029",0.032]
[415,"ENSG00000187244.11","BCAM","chr19","+",44819581,44820822,44819581,44819726,44820704,44820822,415,"8,14","11,32","16,5","14,26",298,149,0.892341296988,1,"0.267,0.179","0.364,0.088",-0.003]
[416,"ENSG00000069399.14","BCL3","chr19","+",44758245,44758841,44758245,44758413,44758723,44758841,416,"2,4","17,17","6,2","28,20",298,149,0.844388723384,0.9934600774751,"0.056,0.105","0.097,0.048",0.008]
[418,"ENSG00000167380.16","ZNF226","chr19","+",44165587,44165807,44165587,44165613,44165756,44165807,418,"39,36","8,2","9,23","3,0",292,149,0.36861048289,0.526824319672605,"0.713,0.902","0.605,1.0",0.005]
[419,"ENSG00000105755.7","ETHE1","chr19","-",43526200,43526659,43526200,43526349,43526514,43526659,419,"6,12",152132,"5,12",112137,298,149,0.877527270183,1,"0.019,0.043","0.022,0.042",-1E-3]
[420,"ENSG00000076928.17","ARHGEF1","chr19","+",41892024,41892373,41892024,41892123,41892330,41892373,420,84130,530577,127134,476503,298,149,0.0211440012515,0.0437540752910377,"0.073,0.101","0.118,0.118",-0.031]
[422,"ENSG00000105341.18","DMAC2","chr19","-",41431318,41433434,41431318,41432408,41433271,41433434,422,111126,209219,314311,132111,298,149,0,0,"0.21,0.223","0.543,0.583",-0.346]
[423,"ENSG00000248098.11","BCKDHA","chr19","+",41410636,41411009,41410636,41410816,41410922,41411009,423,"16,15",535526,"13,25",332388,255,149,0.0290106894963,0.0580336094687788,"0.017,0.016","0.022,0.036",-0.012]
[424,"ENSG00000100124.14","ANKRD54","chr22","-",37832957,37833206,37832957,37833082,37833158,37833206,424,"34,42",103163,"44,53",102113,225,149,0.0264578612512,0.0535362693547735,"0.179,0.146","0.222,0.237",-0.067]
[425,"ENSG00000269858.5","EGLN2","chr19","+",40807137,40807551,40807137,40807274,40807483,40807551,425,"67,53",7981037,164132,816850,298,149,{"v":2.25800489417e-11,"d":"2.26E-11"},{"v":1.59675606897714e-10,"d":"1.60E-10"},"0.04,0.025","0.091,0.072",-0.049]
[428,"ENSG00000167578.17","RAB4B","chr19","+",40780018,40780499,40780018,40780099,40780384,40780499,428,"33,34",112126,"6,9","84,85",298,149,{"v":4.25884669774e-05,"d":"4.26E-05"},0.000144241453110466,"0.128,0.119","0.034,0.05",0.081]
[429,"ENSG00000123815.11","COQ8B","chr19","-",40705095,40705447,40705095,40705181,40705324,40705447,429,90100,107111,"74,72","46,68",292,149,0.0584250690419,0.106831195608406,"0.3,0.315","0.451,0.351",-0.094]
[431,"ENSG00000105223.19","PLD3","chr19","+",40365552,40365930,40365552,40365585,40365717,40365930,431,384396,"5,8",237221,"1,0",281,149,0.0148581946494,0.0320027842085351,"0.976,0.963","0.992,1.0",-0.026]
[434,"ENSG00000013275.7","PSMC4","chr19","+",39980069,39980454,39980069,39980146,39980285,39980454,434,"62,66",19552051,161159,16071485,288,149,{"v":3.33066907388e-16,"d":"3.33E-16"},{"v":3.52768409722334E-15,"d":"3.53E-15"},"0.016,0.016","0.049,0.052",-0.035]
[435,"ENSG00000013275.7","PSMC4","chr19","+",39980285,39980717,39980285,39980454,39980661,39980717,435,"47,38",25822891,"33,46",19831801,298,149,0.731787556323,0.894239493884273,"0.009,0.007","0.008,0.013",-2E-3]
[436,"ENSG00000105202.8","FBL","chr19","-",39834457,39834813,39834457,39834562,39834667,39834813,436,"17,35",17351615,"51,63",13181681,254,149,{"v":8.06621035621e-06,"d":"8.07E-06"},{"v":3.06929977066691e-05,"d":"3.07E-05"},"0.006,0.013","0.022,0.022",-0.012]
[437,"ENSG00000105202.8","FBL","chr19","-",39840616,39840787,39840616,39840682,39840721,39840787,437,479438,"4,1",433572,"5,2",188,149,1,1,"0.99,0.997","0.986,0.996",0.003]
[438,"ENSG00000105204.13","DYRK1B","chr19","-",39826671,39826987,39826671,39826867,39826951,39826987,438,"0,4","2,2","10,5","0,0",233,149,{"v":3.25852035308e-05,"d":"3.26E-05"},1.12122400836581E-4,"0.0,0.561","1.0,1.0",-0.72]
[444,"ENSG00000068903.19","SIRT2","chr19","-",38889688,38889961,38889688,38889745,38889854,38889961,444,"2,2",271334,"17,9",393361,258,149,0.0162959988945,0.0346902264488122,"0.004,0.003","0.024,0.014",-0.015]
[445,"ENSG00000104823.8","ECH1","chr19","-",38815856,38816355,38815856,38816007,38816283,38816355,445,"37,56",13051341,"22,29",823935,298,149,0.324653230548,0.474285584652173,"0.014,0.02","0.013,0.015",0.003]
[446,"ENSG00000104823.8","ECH1","chr19","-",38817315,38817575,38817315,38817364,38817450,38817575,446,"14,4",932931,"5,16",613628,235,149,0.786205610007,0.942056974616973,"0.009,0.003","0.005,0.016",-0.005]
[447,"ENSG00000104814.12","MAP4K1","chr19","-",38595484,38595729,38595484,38595555,38595639,38595729,447,"25,49",141187,"26,32",91102,233,149,0.200887367727,0.315639197962202,"0.102,0.144","0.154,0.167",-0.038]
[448,"ENSG00000104814.12","MAP4K1","chr19","-",38607863,38608033,38607863,38607911,38607989,38608033,448,"11,18",261204,"2,4","122,94",227,149,0.0215020229791,0.0444368898239675,"0.027,0.055","0.011,0.027",0.022]
[449,"ENSG00000130244.12","FAM98C","chr19","+",38403337,38403694,38403337,38403486,38403559,38403694,449,"7,0","31,16","9,11","62,53",222,149,0.477684604786,0.648344808269327,"0.132,0.0","0.089,0.122",-0.039]
[450,"ENSG00000130244.12","FAM98C","chr19","+",38405518,38407077,38405518,38405635,38406909,38407077,450,"25,20","70,46",121107,"19,12",298,149,0,0,"0.152,0.179","0.761,0.817",-0.623]
[451,"ENSG00000099341.11","PSMD8","chr19","+",38376159,38376454,38376159,38376232,38376351,38376454,451,"15,22",30603104,"20,21",28343128,268,149,1,1,"0.003,0.004","0.004,0.004",-1E-3]
[453,"ENSG00000167645.16","YIF1B","chr19","-",38307427,38307752,38307427,38307521,38307596,38307752,453,"34,16",394499,"49,27",373493,224,149,0.0308965029539,0.0611614128144578,"0.054,0.021","0.08,0.035",-0.02]
[454,"ENSG00000167645.16","YIF1B","chr19","-",38309223,38309643,38309223,38309328,38309404,38309643,454,"27,22",905913,"28,21",822875,225,149,0.783676940407,0.939501536693081,"0.019,0.016","0.022,0.016",-1E-3]
[455,"ENSG00000167642.12","SPINT2","chr19","+",38290536,38292468,38290536,38290575,38291839,38292468,455,"23,21",880837,"60,77",11211240,298,149,{"v":2.19206876688E-5,"d":"2.19E-05"},{"v":7.79712616105367e-05,"d":"7.80E-05"},"0.013,0.012","0.026,0.03",-0.015]
[456,"ENSG00000011332.19","DPF1","chr19","-",38217459,38217876,38217459,38217591,38217797,38217876,456,"9,6","28,16","18,24","25,34",298,149,0.0301402141058,0.0599644930532582,"0.138,0.158","0.265,0.261",-0.115]
[457,"ENSG00000188283.11","ZNF383","chr19","+",37235548,37236074,37235548,37235675,37235978,37236074,457,"17,36","45,47",91108,"43,88",298,149,0.000249621988534,0.00074681988372877,"0.159,0.277","0.514,0.38",-0.229]
[459,"ENSG00000105258.8","POLR2I","chr19","-",36114338,36114713,36114338,36114412,36114658,36114713,459,"39,34",12081458,"107,99",791849,298,149,0,0,"0.016,0.012","0.063,0.055",-0.045]
[460,"ENSG00000239382.10","ALKBH6","chr19","-",36013020,36013422,36013020,36013089,36013309,36013422,460,"29,18","0,0","26,45","2,0",298,149,0.913960805582,1,"1.0,1.0","0.867,1.0",0.067]
[461,"ENSG00000239382.10","ALKBH6","chr19","-",36013020,36013422,36013020,36013089,36013327,36013422,461,"30,16","0,0","22,38","0,2",298,149,0.443813273325,0.610292702742163,"1.0,1.0","1.0,0.905",0.047]
[462,"ENSG00000239382.10","ALKBH6","chr19","-",36013020,36013422,36013020,36013089,36013343,36013422,462,"30,16",103101,"23,38",116133,298,149,0.701274773278,0.864522940816864,"0.127,0.073","0.09,0.125",-0.007]
[463,"ENSG00000181392.15","SYNE4","chr19","-",36005332,36006671,36005332,36005437,36006422,36006671,463,"14,11","5,0","7,0","2,0",298,149,1,1,"0.583,1.0","0.636,NA",0.155]
[465,"ENSG00000167604.14","NFKBID","chr19","-",35896725,35897058,35896725,35896831,35896912,35897058,465,"20,32","28,23","33,30","22,23",230,149,0.313472547421,0.46007647309392,"0.316,0.474","0.493,0.458",-0.081]
[481,"ENSG00000064601.18","CTSA","chr20","+",45891568,45892027,45891568,45891762,45891915,45892027,481,"28,37",392428,"47,44",417473,298,149,0.183160715155,0.292133644843857,"0.034,0.041","0.053,0.044",-0.011]
[482,"ENSG00000064601.18","CTSA","chr20","+",45892272,45892484,45892272,45892323,45892397,45892484,482,"52,15",491478,"27,57",376462,223,149,0.0581532326357,0.106416154591745,"0.066,0.021","0.046,0.076",-0.017]
[483,"ENSG00000089327.14","FXYD5","chr19","+",35166141,35166325,35166141,35166171,35166250,35166325,483,"73,69",44023886,174199,32933349,228,149,0,0,"0.011,0.011","0.033,0.037",-0.024]
[487,"ENSG00000266964.5","FXYD1","chr19","+",35142719,35143050,35142719,35142771,35142916,35143050,487,"0,0","2,7","6,11","11,4",294,149,{"v":7.75293042021e-06,"d":"7.75E-06"},{"v":2.96196898904158E-5,"d":"2.96E-05"},"0.0,0.0","0.217,0.582",-0.399]
[489,"ENSG00000153902.13","LGI4","chr19","-",35133692,35134104,35133692,35133764,35134032,35134104,489,"0,0","1,0","0,1","0,0",298,149,1,1,"0.0,NA","NA,1.0",-1]
[490,"ENSG00000089356.18","FXYD3","chr19","+",35122764,35122954,35122764,35122839,35122917,35122954,490,"0,0","2,0","1,0","0,0",227,149,1,1,"0.0,NA","1.0,NA",-1]
[491,"ENSG00000197841.14","ZNF181","chr19","+",34739147,34739621,34739147,34739268,34739522,34739621,491,"17,16","36,31","71,87","35,52",298,149,{"v":3.75250678086E-7,"d":"3.75E-07"},{"v":1.710436568221e-06,"d":"1.71E-06"},"0.191,0.205","0.504,0.455",-0.282]
[492,"ENSG00000197841.14","ZNF181","chr19","+",34739147,34739621,34739147,34739268,34739525,34739621,492,"18,16","29,30","69,86","42,26",298,149,{"v":1.39822314417E-5,"d":"1.40E-05"},{"v":5.15106274773808e-05,"d":"5.15E-05"},"0.237,0.211","0.451,0.623",-0.313]
[497,"ENSG00000184162.14","NR2C2AP","chr19","-",19201415,19202041,19201415,19201563,19201930,19202041,497,350245,"11,6",193203,"1,1",298,149,0.000919388330209,2.50286725578984E-3,"0.941,0.953","0.99,0.99",-0.043]
[498,"ENSG00000064607.16","SUGP2","chr19","-",18990887,18993740,18990887,18991149,18993637,18993740,498,646561,"112,81",944868,"5,11",298,149,0,0,"0.743,0.776","0.99,0.975",-0.223]
[499,"ENSG00000064607.16","SUGP2","chr19","-",18994365,18995280,18994365,18994486,18995143,18995280,499,369419,241213,338389,456487,298,149,{"v":1.06724740156E-10,"d":"1.07E-10"},{"v":7.09256151316834E-10,"d":"7.09E-10"},"0.434,0.496","0.27,0.285",0.188]
[500,"ENSG00000064607.16","SUGP2","chr19","-",19004167,19004646,19004167,19004273,19004429,19004646,500,10241017,"17,19",14741605,"42,17",298,149,0.678182238744,0.84174070699458,"0.968,0.964","0.946,0.979",0.004]
[501,"ENSG00000064607.16","SUGP2","chr19","-",19024618,19026226,19024618,19025456,19025854,19026226,501,11811091,"8,8",14851553,"8,0",298,149,0.542987288544,0.715031437362,"0.987,0.986","0.989,1.0",-0.008]
[503,"ENSG00000105643.9","ARRDC2","chr19","+",18008169,18008584,18008169,18008228,18008453,18008584,503,"3,27","0,0",265215,"4,13",298,149,0.00427585923115,0.0103961923886943,"1.0,1.0","0.971,0.892",0.069]
[504,"ENSG00000105643.9","ARRDC2","chr19","+",18008167,18008777,18008167,18008584,18008710,18008777,504,"10,14","1,9","42,33",143170,275,149,{"v":2.76152222711e-05,"d":"2.76E-05"},{"v":9.62779057137174e-05,"d":"9.63E-05"},"0.844,0.457","0.137,0.095",0.534]
[505,"ENSG00000156261.12","CCT8","chr21","-",29066715,29067071,29066715,29066777,29066890,29067071,505,176186,62456023,180195,59245826,262,149,0.56288919836,0.732759738331467,"0.016,0.017","0.017,0.019",-2E-3]
[506,"ENSG00000130304.16","SLC27A1","chr19","+",17486562,17487335,17486562,17486957,17487099,17487335,506,"6,0","2,0","4,5","0,0",291,149,1,1,"0.606,NA","1.0,1.0",-0.394]
[507,"ENSG00000130304.16","SLC27A1","chr19","+",17486562,17487335,17486562,17486957,17487173,17487335,507,"8,0","2,10","4,6","0,2",298,149,0.00743479464325,0.0172424734028451,"0.667,0.0","1.0,0.6",-0.467]
[508,"ENSG00000160117.14","ANKLE1","chr19","+",17282655,17283002,17282655,17282761,17282863,17283002,508,"38,28",165229,135136,"105,91",251,149,0,0,"0.12,0.068","0.433,0.47",-0.358]
[510,"ENSG00000130307.11","USHBP1","chr19","-",17258211,17258701,17258211,17258385,17258583,17258701,510,"6,0","0,0","8,5","5,0",298,149,1,1,"1.0,NA","0.444,1.0",0.278]
[511,"ENSG00000130307.11","USHBP1","chr19","-",17262551,17264150,17262551,17262990,17264001,17264150,511,"0,0","0,2","3,1","1,2",298,149,1,1,"NA,0.0","0.6,0.2",-0.4]
[512,"ENSG00000053501.12","USE1","chr19","+",17215801,17216070,17215801,17215851,17215991,17216070,512,"16,9",185200,"14,10","53,71",289,149,1.19627419976E-3,0.00318715388987153,"0.043,0.023","0.12,0.068",-0.061]
[513,"ENSG00000196684.12","HSH2D","chr19","+",16152551,16153208,16152551,16152641,16153031,16153208,513,"5,3","0,2","5,9","0,0",298,149,0.383414518006,0.54210425743101,"1.0,0.429","1.0,1.0",-0.285]
[514,"ENSG00000196684.12","HSH2D","chr19","+",16152551,16153208,16152551,16152641,16153042,16153208,514,"5,3","5,2","5,11","7,2",298,149,0.558861142285,0.72871561421883,"0.333,0.429","0.263,0.733",-0.117]
[517,"ENSG00000011243.17","AKAP8L","chr19","-",15398629,15399410,15398629,15398703,15399301,15399410,517,218260,"15,14",454435,"19,19",298,149,0.229601996636,0.353377059370035,"0.879,0.903","0.923,0.92",-0.03]
[518,"ENSG00000011243.17","AKAP8L","chr19","-",15398629,15399410,15398629,15398766,15399301,15399410,518,226287,"66,59",459444,"11,31",298,149,{"v":3.33066907388E-15,"d":"3.33E-15"},{"v":3.25856180527022e-14,"d":"3.26E-14"},"0.631,0.709","0.954,0.877",-0.246]
[519,"ENSG00000011243.17","AKAP8L","chr19","-",15403474,15403715,15403474,15403555,15403652,15403715,519,856832,"12,7",10101041,"0,3",246,149,0.0804615604916,0.142087869197112,"0.977,0.986","1.0,0.995",-0.016]
[520,"ENSG00000011243.17","AKAP8L","chr19","-",15403474,15403715,15403474,15403555,15403657,15403715,520,883848,107121,10381076,"41,40",251,149,{"v":1.62092561595E-14,"d":"1.62E-14"},{"v":1.51403386765408e-13,"d":"1.51E-13"},"0.83,0.806","0.938,0.941",-0.121]
[521,"ENSG00000011243.17","AKAP8L","chr19","-",15403474,15404042,15403474,15403555,15404009,15404042,521,518515,"4,6",626615,"17,9",298,149,0.0241595344664,0.0492638551968491,"0.985,0.977","0.948,0.972",0.021]
[522,"ENSG00000011243.17","AKAP8L","chr19","-",15403474,15404042,15403474,15403715,15404009,15404042,522,"39,30",620622,"81,65",594660,298,149,{"v":2.77511605202e-05,"d":"2.78E-05"},{"v":9.66098728307769e-05,"d":"9.66E-05"},"0.03,0.024","0.064,0.047",-0.029]
[524,"ENSG00000127507.17","ADGRE2","chr19","-",14765657,14766381,14765657,14765804,14766234,14766381,524,"30,15","0,2","9,9","4,2",298,149,2.75334383343E-3,0.00693819250643937,"1.0,0.789","0.529,0.692",0.284]
[525,"ENSG00000160961.11","ZNF333","chr19","+",14716993,14717733,14716993,14717089,14717656,14717733,525,"24,12","45,36","27,40","61,73",298,149,0.595416646708,0.763854851711719,"0.211,0.143","0.181,0.215",-0.021]
[526,"ENSG00000099797.14","TECR","chr19","+",14563657,14563903,14563657,14563702,14563770,14563903,526,"42,44","14,3","91,56","7,7",217,149,0.1723050846,0.276679399806091,"0.673,0.91","0.899,0.846",-0.081]
[527,"ENSG00000099797.14","TECR","chr19","+",14563657,14563903,14563657,14563702,14563799,14563903,527,"55,53",20832092,"99,62",16401723,246,149,0.000144094081113,0.000446296615457692,"0.016,0.015","0.035,0.021",-0.013]
[528,"ENSG00000099797.14","TECR","chr19","+",14563657,14563903,14563657,14563702,14563834,14563903,528,654634,"11,14",533487,"13,13",281,149,0.379448948392,0.538422625633983,"0.969,0.96","0.956,0.952",0.01]
[529,"ENSG00000099797.14","TECR","chr19","+",14563981,14564287,14563981,14564097,14564181,14564287,529,"53,62",17711797,"67,75",12561250,233,149,0.000538534981368,0.00152558118602457,"0.019,0.022","0.033,0.037",-0.015]
[530,"ENSG00000099797.14","TECR","chr19","+",14564785,14564992,14564785,14564858,14564948,14564992,530,"92,79",18721861,205139,12571313,239,149,{"v":1.04360964315E-14,"d":"1.04E-14"},{"v":9.86439792180627e-14,"d":"9.86E-14"},"0.03,0.026","0.092,0.062",-0.049]
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[631,"ENSG00000126934.13","MAP2K2","chr19","-",4094452,4095449,4094452,4094498,4095387,4095449,631,"62,49",1003968,"46,48",835894,298,149,0.851429729802,0.999389144677202,"0.03,0.025","0.027,0.026",1E-3]
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[639,"ENSG00000161091.12","MFSD12","chr19","-",3544198,3544732,3544198,3544307,3544354,3544732,639,214162,"3,1",106119,"0,0",196,149,0.801929561853,0.954869704138641,"0.982,0.992","1.0,1.0",-0.013]
[640,"ENSG00000105325.13","FZR1","chr19","+",3526119,3526386,3526119,3526183,3526258,3526386,640,"8,15",225271,"22,39",242295,224,149,0.000415685006616,1.20123346917961E-3,"0.023,0.036","0.057,0.081",-0.04]
[641,"ENSG00000125912.10","NCLN","chr19","+",3207628,3209575,3207628,3207747,3209477,3209575,641,760651,"2,0",606797,"0,3",298,149,1,1,"0.995,1.0","1.0,0.993",1E-3]
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[648,"ENSG00000099875.14","MKNK2","chr19","-",2037464,2039856,2037464,2037829,2039630,2039856,648,598626,"2,1",478374,"0,0",298,149,1,1,"0.993,0.997","1.0,1.0",-0.005]
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[652,"ENSG00000129968.15","ABHD17A","chr19","-",1877507,1880115,1877507,1877687,1878663,1880115,652,222191,"7,4",696813,"1,1",298,149,0.000551580927451,1.55881566453543E-3,"0.941,0.96","0.997,0.998",-0.047]
[653,"ENSG00000129968.15","ABHD17A","chr19","-",1877507,1880115,1877507,1877687,1879920,1880115,653,141141,558719,533552,247243,298,149,0,0,"0.112,0.089","0.519,0.532",-0.425]
[654,"ENSG00000071564.14","TCF3","chr19","-",1609292,1611849,1609292,1610500,1611703,1611849,654,11671225,"26,30",1035974,"0,7",298,149,{"v":2.13638449154e-08,"d":"2.14E-08"},{"v":1.13137772459344e-07,"d":"1.13E-07"},"0.957,0.953","1.0,0.986",-0.038]
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[656,"ENSG00000071564.14","TCF3","chr19","-",1615284,1615821,1615284,1615515,1615685,1615821,656,"31,67","13,9","72,36","11,10",298,149,0.686006859653,0.84878814838422,"0.544,0.788","0.766,0.643",-0.038]
[657,"ENSG00000071564.14","TCF3","chr19","-",1615284,1615821,1615284,1615520,1615685,1615821,657,"28,53",512487,"67,35",338342,298,149,0.00101686418729,0.00274616993095677,"0.027,0.052","0.09,0.049",-0.03]
[658,"ENSG00000071564.14","TCF3","chr19","-",1619110,1619474,1619110,1619234,1619315,1619474,658,"24,29",10341106,"49,32",601630,230,149,{"v":1.77610707219e-06,"d":"1.78E-06"},{"v":7.42522295818638e-06,"d":"7.43E-06"},"0.015,0.017","0.05,0.032",-0.025]
[659,"ENSG00000115268.9","RPS15","chr19","+",1438806,1440253,1438806,1438892,1439960,1440253,659,"56,47","4,4","53,51","8,5",298,149,0.268777534324,0.40359158239474,"0.875,0.855","0.768,0.836",0.063]
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[663,"ENSG00000115268.9","RPS15","chr19","+",1440018,1440494,1440018,1440253,1440348,1440494,663,"82,80",1544316359,"67,93",1913422749,244,149,1,1,"0.003,0.003","0.002,0.002",1E-3]
[664,"ENSG00000115286.19","NDUFS7","chr19","+",1388524,1388938,1388524,1388593,1388742,1388938,664,"20,19","0,4","39,44","2,7",298,149,0.603527145452,0.771896578212868,"1.0,0.704","0.907,0.759",0.019]
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[667,"ENSG00000115286.19","NDUFS7","chr19","+",1390870,1391165,1390870,1391050,1391118,1391165,667,"30,58",11231399,"85,60",8301016,217,149,{"v":1.1039015263E-6,"d":"1.10E-06"},{"v":4.71893039846261e-06,"d":"4.72E-06"},"0.018,0.028","0.066,0.039",-0.03]
[668,"ENSG00000115286.19","NDUFS7","chr19","+",1393241,1395584,1393241,1393330,1395390,1395584,668,"26,67",615754,348449,437442,298,149,0,0,"0.021,0.043","0.285,0.337",-0.279]
[669,"ENSG00000099622.13","CIRBP","chr19","+",1270927,1271467,1270927,1271036,1271139,1271467,669,122123,20791762,110105,20302396,252,149,0.051798461232,0.0963102267029153,"0.034,0.04","0.031,0.025",0.009]
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[672,"ENSG00000099622.13","CIRBP","chr19","+",1271139,1271632,1271139,1271365,1271550,1271632,672,1025949,"11,12",12171557,"55,59",298,149,{"v":1.82154544781e-08,"d":"1.82E-08"},{"v":9.71149792118927E-8,"d":"9.71E-08"},"0.979,0.975","0.917,0.93",0.053]
[673,"ENSG00000099622.13","CIRBP","chr19","+",1271139,1271632,1271139,1271467,1271550,1271632,673,"48,32",299342,"67,49",355396,232,149,0.236616358736,0.362175684581393,"0.093,0.057","0.108,0.074",-0.016]
[674,"ENSG00000099622.13","CIRBP","chr19","+",1271980,1273172,1271980,1272051,1272426,1273172,674,564580,16411504,353386,20312083,298,149,{"v":3.97278654418e-10,"d":"3.97E-10"},{"v":2.45134878441275e-09,"d":"2.45E-09"},"0.147,0.162","0.08,0.085",0.072]
[675,"ENSG00000099622.13","CIRBP","chr19","+",1271980,1274440,1271980,1272051,1274306,1274440,675,377371,106104,228242,84154,298,149,0.00555494118815,0.0131790979688858,"0.64,0.641","0.576,0.44",0.133]
[676,"ENSG00000099622.13","CIRBP","chr19","+",1274306,1274810,1274306,1274440,1274648,1274810,676,125139,288289,181179,"112,94",298,149,0,0,"0.178,0.194","0.447,0.488",-0.282]
[678,"ENSG00000099624.7","ATP5F1D","chr19","+",1244314,1244825,1244314,1244440,1244736,1244825,678,434460,556687,571647,117161,298,149,0,0,"0.281,0.251","0.709,0.668",-0.422]
[679,"ENSG00000099625.13","CBARP","chr19","-",1228286,1231275,1228286,1230142,1231100,1231275,679,"10,13","18,2","29,14","1,4",298,149,0.0398250489734,0.0767234500116861,"0.217,0.765","0.935,0.636",-0.295]
[680,"ENSG00000118046.14","STK11","chr19","+",1220372,1220717,1220372,1220505,1220580,1220717,680,43106,354355,100114,406408,224,149,0.126658101954,0.211691685019982,"0.075,0.166","0.141,0.157",-0.028]
[681,"ENSG00000118046.14","STK11","chr19","+",1221212,1222006,1221212,1221340,1221948,1222006,681,"38,38",415405,"78,58",301348,298,149,{"v":5.2012668742e-06,"d":"5.20E-06"},{"v":2.03798607085706e-05,"d":"2.04E-05"},"0.044,0.045","0.115,0.077",-0.052]
[684,"ENSG00000180448.10","ARHGAP45","chr19","+",1080254,1080547,1080254,1080379,1080463,1080547,684,"11,19",205315,"14,2",240284,233,149,0.0423252825192,0.080753303399117,"0.033,0.037","0.036,0.004",0.015]
[693,"ENSG00000011304.19","PTBP1","chr19","+",804291,804702,804291,804438,804540,804702,693,348443,"36,56",517426,"54,53",251,149,0.934976552406,1,"0.852,0.824","0.85,0.827",-1E-3]
[704,"ENSG00000075336.11","TIMM21","chr18","+",74155144,74155403,74155144,74155207,74155305,74155403,704,133114,440402,164142,202215,247,149,{"v":1.96602512048E-10,"d":"1.97E-10"},{"v":1.25386951568247e-09,"d":"1.25E-09"},"0.154,0.146","0.329,0.285",-0.157]
[721,"ENSG00000176014.12","TUBB6","chr18","+",12308240,12308795,12308240,12308349,12308686,12308795,721,"8,3",320320,"10,14",122188,298,149,{"v":7.79469401655e-05,"d":"7.79E-05"},0.000251947023900066,"0.012,0.005","0.039,0.036",-0.029]
[738,"ENSG00000169718.17","DUS1L","chr17","-",82058340,82058818,82058340,82058408,82058780,82058818,738,408423,117127,513463,"63,60",298,149,{"v":4.02743632888E-8,"d":"4.03E-08"},{"v":2.06150867103943e-07,"d":"2.06E-07"},"0.636,0.625","0.803,0.794",-0.168]
[745,"ENSG00000183010.16","PYCR1","chr17","-",81936747,81937257,81936747,81936861,81937227,81937257,745,149136,"6,5","108,84","0,0",298,149,0.000614224480521,1.72048120429288E-3,"0.925,0.932","1.0,1.0",-0.071]
[761,"ENSG00000089685.14","BIRC5","chr17","+",78215965,78216781,78215965,78216066,78216663,78216781,761,"53,34","1,0","23,25","0,0",298,149,1,1,"0.964,1.0","1.0,1.0",-0.018]
[766,"ENSG00000167895.14","TMC8","chr17","+",78137234,78137814,78137234,78137323,78137716,78137814,766,256253,"58,37",541575,"1,0",298,149,0,0,"0.688,0.774","0.996,1.0",-0.267]
[782,"ENSG00000132470.13","ITGB4","chr17","+",75757199,75757818,75757199,75757310,75757415,75757818,782,"0,0","4,7","1,0","2,1",254,149,1,1,"0.0,0.0","0.227,0.0",-0.114]
[792,"ENSG00000177728.16","TMEM94","chr17","+",75492928,75493593,75492928,75493102,75493490,75493593,792,105101,100136,100123,"74,86",298,149,0.00904833266615,0.0206912474703044,"0.344,0.271","0.403,0.417",-0.103]
[803,"ENSG00000109065.11","NAT9","chr17","-",74771959,74772277,74771959,74772039,74772217,74772277,803,140118,"9,6",181248,"7,18",298,149,0.818232643484,0.969416702454826,"0.886,0.908","0.928,0.873",-0.004]
[817,"ENSG00000087191.12","PSMC5","chr17","+",63827459,63827923,63827459,63827514,63827673,63827923,817,"77,34","0,0",387324,"2,2",298,149,1,1,"1.0,1.0","0.99,0.988",0.011]
[842,"ENSG00000006282.20","SPATA20","chr17","+",50548282,50548618,50548282,50548453,50548553,50548618,842,"4,4",99105,"3,7","75,68",249,149,0.253897711755,0.385148542927581,"0.024,0.022","0.023,0.058",-0.018]
[852,"ENSG00000121073.14","SLC35B1","chr17","-",49705123,49706309,49705123,49705281,49706203,49706309,852,"39,34","0,0","42,42","3,3",298,149,0.0020140418468,0.00519664413434801,"1.0,1.0","0.875,0.875",0.125]
[861,"ENSG00000108465.14","CDK5RAP3","chr17","+",47974399,47975337,47974399,47974448,47975171,47975337,861,869896,"4,5",995988,"3,9",298,149,0.833260498931,0.984027144705723,"0.991,0.989","0.994,0.982",2E-3]
[862,"ENSG00000108465.14","CDK5RAP3","chr17","+",47975513,47976013,47975513,47975638,47975868,47976013,862,916932,"14,10",796896,"1,0",298,149,0.00117035691975,0.00312512300743598,"0.97,0.979","0.997,1.0",-0.024]
[875,"ENSG00000108883.12","EFTUD2","chr17","-",44853516,44854356,44853516,44853635,44854268,44854356,875,"62,38",808674,"84,96",421405,298,149,{"v":5.61217738948e-13,"d":"5.61E-13"},{"v":4.6555562435459e-12,"d":"4.66E-12"},"0.037,0.027","0.091,0.106",-0.067]
[885,"ENSG00000013306.15","SLC25A39","chr17","-",44321057,44321558,44321057,44321231,44321433,44321558,885,177180,888900,335307,654704,298,149,{"v":4.53137527501e-12,"d":"4.53E-12"},{"v":3.40211640505102e-11,"d":"3.40E-11"},"0.091,0.091","0.204,0.179",-0.101]
[897,"ENSG00000126581.12","BECN1","chr17","-",42818786,42819609,42818786,42818877,42819547,42819609,897,"53,81",497457,149130,137132,298,149,0,0,"0.051,0.081","0.352,0.33",-0.275]
[909,"ENSG00000168256.17","NKIRAS2","chr17","+",42022398,42022640,42022398,42022472,42022564,42022640,909,314327,"58,36",519424,"51,24",241,149,0.00180516543279,0.004693430125254,"0.77,0.849","0.863,0.916",-0.08]
[926,"ENSG00000131748.15","STARD3","chr17","+",39662250,39663484,39662250,39662367,39662803,39663484,926,"43,42","4,5","77,80","3,12",298,149,0.788601937991,0.943748437935697,"0.843,0.808","0.928,0.769",-0.023]
[941,"ENSG00000196712.17","NF1","chr17","+",31229024,31229974,31229024,31229465,31229834,31229974,941,"10,8","82,63","0,1","88,43",298,149,{"v":6.87098412696e-05,"d":"6.87E-05"},0.000224228470993295,"0.057,0.06","0.0,0.011",0.053]
[952,"ENSG00000109111.14","SUPT6H","chr17","+",28700345,28701128,28700345,28700512,28700940,28701128,952,"15,8",639755,"40,42",366373,298,149,{"v":2.6645352591e-15,"d":"2.66E-15"},{"v":2.62852802586891e-14,"d":"2.63E-14"},"0.012,0.005","0.052,0.053",-0.044]
[953,"ENSG00000076382.16","SPAG5","chr17","-",28578009,28578292,28578009,28578090,28578217,28578292,953,"103,59",703778,197193,488509,276,149,0,0,"0.073,0.039","0.179,0.17",-0.118]
[974,"ENSG00000108641.15","B9D1","chr17","-",19343169,19343857,19343169,19343461,19343789,19343857,974,"1,5","18,26","5,2","10,3",298,149,0.054903581986,0.101526693890713,"0.027,0.088","0.2,0.25",-0.168]
[990,"ENSG00000108591.9","DRG2","chr17","+",18099016,18100435,18099016,18099077,18099632,18100435,990,"47,34",331383,"121,94","124,74",298,149,0,0,"0.066,0.042","0.328,0.388",-0.304]
[1001,"ENSG00000105122.12","RASAL3","chr19","-",15451623,15452815,15451623,15451938,15452657,15452815,1001,"61,49","11,6",90119,"25,45",298,149,0.00769145379115,0.0178115901605694,"0.735,0.803","0.643,0.569",0.163]
[1010,"ENSG00000175061.17","LRRC75A-AS1","chr17","+",16439326,16440253,16439326,16439414,16440184,16440253,1010,993894,41123634,504554,982011627,298,149,0,0,"0.108,0.11","0.025,0.023",0.085]
[1023,"ENSG00000076984.17","MAP2K7","chr19","+",7910062,7910373,7910062,7910129,7910259,7910373,1023,"14,9",266195,"28,23",359348,279,149,0.139868956213,0.230204022625974,"0.027,0.024","0.04,0.034",-0.012]
[1032,"ENSG00000179029.14","TMEM107","chr17","-",8175756,8176026,8175756,8175875,8175958,8176026,1032,"8,10","6,1","9,15","1,3",232,149,0.316622132328,0.463838227198629,"0.461,0.865","0.853,0.763",-0.145]
[1046,"ENSG00000161960.14","EIF4A1","chr17","+",7574259,7574678,7574259,7574308,7574547,7574678,1046,179193,"56,57",225266,"49,80",298,149,0.398527478813,0.559305793246875,"0.615,0.629","0.697,0.624",-0.038]
[1047,"ENSG00000161960.14","EIF4A1","chr17","+",7576523,7577165,7576523,7576690,7577055,7577165,1047,332360,"0,1",313316,"1,1",298,149,1,1,"1.0,0.994","0.994,0.994",0.003]
[1057,"ENSG00000187838.16","PLSCR3","chr17","-",7393600,7394159,7393600,7393836,7394103,7394159,1057,"4,13","25,54","29,27","26,39",298,149,{"v":1.64356070229e-05,"d":"1.64E-05"},{"v":5.95320269646263e-05,"d":"5.95E-05"},"0.074,0.107","0.358,0.257",-0.217]
[1068,"ENSG00000072778.19","ACADVL","chr17","+",7224320,7224552,7224320,7224393,7224483,7224552,1068,"10,24","59,54","25,32","33,63",239,149,0.0173647111448,0.0367018059608356,"0.096,0.217","0.321,0.241",-0.125]
[1080,"ENSG00000184922.13","FMNL1","chr17","+",45243790,45244244,45243790,45244025,45244175,45244244,1080,"32,28",396465,"29,5",363319,298,149,0.12988028227,0.216011896029144,"0.039,0.029","0.038,0.008",0.011]
[1093,"ENSG00000141258.12","SGSM2","chr17","+",2362837,2363134,2362837,2362905,2362988,2363134,1093,"47,57","72,47","43,61","82,89",232,149,0.134366014535,0.222226120240005,"0.295,0.438","0.252,0.306",0.087]
[1107,"ENSG00000167526.13","RPL13","chr16","+",89560939,89561368,89560939,89561063,89561226,89561368,1107,289296,1308515701,12631211,2313524950,298,149,{"v":1.11022302463e-16,"d":"1.11E-16"},{"v":1.20825877336452E-15,"d":"1.21E-15"},"0.011,0.009","0.027,0.024",-0.016]
[1117,"ENSG00000197912.15","SPG7","chr16","+",89540943,89542279,89540943,89540977,89541201,89542279,1117,381370,"0,0",202178,"0,1",298,149,1,1,"1.0,1.0","1.0,0.989",0.006]
[1129,"ENSG00000197912.15","SPG7","chr16","+",89556886,89557747,89556886,89557173,89557271,89557747,1129,872777,"10,6",528467,"7,6",247,149,0.536477133704,0.708625938723657,"0.981,0.987","0.978,0.979",0.006]
[1130,"ENSG00000182944.17","EWSR1","chr22","+",29288605,29291599,29288605,29288786,29291561,29291599,1130,594601,818729,333339,621682,298,149,0.000543322429471,0.00153639149454105,"0.266,0.292","0.211,0.199",0.074]
[1139,"ENSG00000167508.11","MVD","chr16","-",88657435,88658029,88657435,88657582,88657914,88658029,1139,"75,78",204164,"27,26",127115,298,149,1.05441556561E-3,0.00284111405952268,"0.155,0.192","0.096,0.102",0.074]
[1159,"ENSG00000124067.16","SLC12A4","chr16","-",67950653,67951060,67950653,67950711,67950961,67951060,1159,"1,1","23,20","0,0","15,6",298,149,0.577755097728,0.744351870409818,"0.021,0.024","0.0,0.0",0.022]
[1167,"ENSG00000159753.13","CARMIL2","chr16","+",67645539,67645777,67645539,67645631,67645723,67645777,1167,"10,7","12,12","14,6","5,11",241,149,0.352988220181,0.508478781043972,"0.34,0.265","0.634,0.252",-0.141]
[1179,"ENSG00000102878.16","HSF4","chr16","+",67165945,67166395,67165945,67166011,67166319,67166395,1179,"26,52","2,2","25,37","3,0",298,149,0.705455221835,0.867872706146506,"0.867,0.929","0.806,1.0",-0.005]
[1192,"ENSG00000133460.19","SLC2A11","chr22","+",23882758,23884024,23882758,23882869,23883948,23884024,1192,"14,7","0,4","21,21","0,0",298,149,0.00850645093486,0.0195842356554637,"1.0,0.467","1.0,1.0",-0.266]
[1204,"ENSG00000089280.18","FUS","chr16","+",31184938,31188357,31184938,31185179,31188324,31188357,1204,11971075,"112,88",615641,162185,298,149,{"v":1.11022302463e-16,"d":"1.11E-16"},{"v":1.20825877336452E-15,"d":"1.21E-15"},"0.842,0.859","0.655,0.634",0.206]
[1214,"ENSG00000156873.15","PHKG2","chr16","+",30751105,30751603,30751105,30751217,30751548,30751603,1214,342329,"13,3",537522,"18,14",298,149,0.375046459928,0.534137302263605,"0.929,0.982","0.937,0.949",0.012]
[1215,"ENSG00000156873.15","PHKG2","chr16","+",30751105,30751603,30751105,30751281,30751548,30751603,1215,314344,173140,515529,"75,96",298,149,{"v":2.44715359088e-12,"d":"2.45E-12"},{"v":1.88808842093099e-11,"d":"1.89E-11"},"0.476,0.551","0.774,0.734",-0.24]
[1226,"ENSG00000103502.13","CDIPT","chr16","-",29860580,29861259,29860580,29860662,29861105,29861259,1226,"17,13",307316,"21,25",308210,298,149,0.0158922098179,0.0340291225568301,"0.027,0.02","0.033,0.056",-0.021]
[1238,"ENSG00000168488.18","ATXN2L","chr16","+",28835932,28837237,28835932,28836122,28836750,28837237,1238,606584,"90,60",11191385,"68,57",298,149,{"v":1.20247034552e-08,"d":"1.20E-08"},{"v":6.52082490227702e-08,"d":"6.52E-08"},"0.771,0.83","0.892,0.924",-0.108]
[1247,"ENSG00000188603.19","CLN3","chr16","-",28487455,28488662,28487455,28487541,28488590,28488662,1247,"19,24","5,14","40,31",106113,298,149,{"v":1.35203180762e-07,"d":"1.35E-07"},{"v":6.467127950763e-07,"d":"6.47E-07"},"0.655,0.462","0.159,0.121",0.418]
[1258,"ENSG00000103365.15","GGA2","chr16","-",23493359,23494378,23493359,23493458,23494302,23494378,1258,88101,250244,"63,57",237228,298,149,0.0167668396688,0.0355489965274602,"0.15,0.171","0.117,0.111",0.046]
[1274,"ENSG00000179889.18","PDXDC1","chr16","+",15031734,15032979,15031734,15031906,15032860,15032979,1274,"18,31",482443,"32,20",445404,298,149,0.542655921904,0.715031437362,"0.018,0.034","0.035,0.024",-0.003]
[1285,"ENSG00000153406.13","NMRAL1","chr16","-",4474092,4474792,4474092,4474166,4474553,4474792,1285,"85,99",143115,"32,34","30,20",298,149,0.0182752832996,0.0384550861448345,"0.229,0.301","0.348,0.459",-0.138]
[1296,"ENSG00000131652.13","THOC6","chr16","+",3025923,3026288,3025923,3025988,3026250,3026288,1296,151104,"1,2",125114,"6,2",298,149,0.0543144256347,0.10055479892183,"0.987,0.963","0.912,0.966",0.036]
[1297,"ENSG00000131652.13","THOC6","chr16","+",3025923,3026288,3025923,3026166,3026250,3026288,1297,"109,89",850935,"94,84",384469,233,149,{"v":2.56381590361e-05,"d":"2.56E-05"},{"v":8.98471673754021e-05,"d":"8.98E-05"},"0.076,0.057","0.135,0.103",-0.052]
[1308,"ENSG00000215301.10","DDX3X","chrX","+",41341483,41342653,41341483,41341616,41342494,41342653,1308,"68,64",16771528,"75,75",17921613,298,149,0.68272766879,0.845833626216331,"0.02,0.021","0.02,0.023",-1E-3]
[1319,"ENSG00000215301.10","DDX3X","chrX","+",41347311,41349886,41347311,41347451,41347639,41349886,1319,183124,12731159,365331,11461162,298,149,{"v":1.38711264697e-12,"d":"1.39E-12"},{"v":1.10992403201899E-11,"d":"1.11E-11"},"0.067,0.051","0.137,0.125",-0.072]
[1327,"ENSG00000103197.17","TSC2","chr16","+",2081594,2082504,2081594,2081798,2082435,2082504,1327,"30,52","2,0","79,81","3,6",298,149,0.0327065926424,0.0643686362870958,"0.882,1.0","0.929,0.871",0.041]
[1341,"ENSG00000140988.15","RPS2","chr16","-",1962060,1962656,1962060,1962270,1962496,1962656,1341,707661,3618737060,641664,3383341391,298,149,1,1,"0.01,0.009","0.009,0.008",1E-3]
[1350,"ENSG00000095906.16","NUBP2","chr16","+",1786536,1787831,1786536,1786955,1787676,1787831,1350,"54,59",248323,124106,194175,298,149,{"v":2.7142732506e-12,"d":"2.71E-12"},{"v":2.0806504966231E-11,"d":"2.08E-11"},"0.098,0.084","0.242,0.232",-0.146]
[1363,"ENSG00000103253.18","HAGHL","chr16","+",728115,728424,728115,728233,728315,728424,1363,"25,48","72,94","19,46","75,51",231,149,0.713615334525,0.876547958146809,"0.183,0.248","0.14,0.368",-0.039]
[1373,"ENSG00000127580.16","WDR24","chr16","-",685868,686186,685868,685990,686067,686186,1373,"18,40","119,86","79,95","27,19",226,149,0,0,"0.091,0.235","0.659,0.767",-0.55]
[1374,"ENSG00000182310.14","SPACA6","chr19","+",51704029,51704480,51704029,51704186,51704269,51704480,1374,"4,10","26,27","12,19","26,29",232,149,0.036806275595,0.0715761384009323,"0.09,0.192","0.229,0.296",-0.121]
[1383,"ENSG00000140983.13","RHOT2","chr16","+",670122,670357,670122,670175,670265,670357,1383,"85,93","100,48","67,76","20,24",239,149,0.00198982736732,0.00514255493351492,"0.346,0.547","0.676,0.664",-0.224]
[1392,"ENSG00000161996.18","WDR90","chr16","+",655772,656537,655772,655885,656301,656537,1392,"30,33","9,11","94,63","5,0",298,149,{"v":3.40868227422E-7,"d":"3.41E-07"},{"v":1.56121596439902e-06,"d":"1.56E-06"},"0.625,0.6","0.904,1.0",-0.339]
[1400,"ENSG00000242612.6","DECR2","chr16","+",406345,406833,406345,406397,406735,406833,1400,"16,13","3,6","18,12","15,5",298,149,0.155087346757,0.252535847756336,"0.727,0.52","0.375,0.545",0.163]
[1412,"ENSG00000161981.10","SNRNP25","chr16","+",55776,56613,55776,55882,56538,56613,1412,"11,21",1014919,"18,24",527542,298,149,0.00419922815971,0.0102233646063745,"0.005,0.011","0.017,0.022",-0.011]
[1425,"ENSG00000196547.14","MAN2A2","chr15","+",90912042,90912664,90912042,90912279,90912516,90912664,1425,252228,155182,297420,172169,298,149,0.0160759907402,0.034301131981319,"0.448,0.385","0.463,0.554",-0.092]
[1434,"ENSG00000087088.19","BAX","chr19","+",48960809,48961798,48960809,48960914,48961531,48961798,1434,538598,960821,10301087,232286,298,149,0,0,"0.219,0.267","0.689,0.655",-0.429]
[1436,"ENSG00000141452.9","RMC1","chr18","+",23530228,23530612,23530228,23530297,23530386,23530612,1436,"35,2",220165,"45,30",146153,238,149,{"v":2.43312835406E-5,"d":"2.43E-05"},{"v":8.56468400594562e-05,"d":"8.56E-05"},"0.091,0.008","0.162,0.109",-0.086]
[1450,"ENSG00000106263.17","EIF3B","chr7","+",2366316,2366591,2366316,2366448,2366524,2366591,1450,"129,89",13401235,104140,701652,225,149,{"v":7.32624962918e-08,"d":"7.33E-08"},{"v":3.62492747554318e-07,"d":"3.62E-07"},"0.06,0.046","0.089,0.124",-0.053]
[1460,"ENSG00000271853.5","AL162258.1","chr1","-",153632033,153632240,153632033,153632063,153632154,153632240,1460,95106,"30,33",186225,"7,3",240,149,0,0,"0.663,0.666","0.943,0.979",-0.296]
[1477,"ENSG00000179532.12","DNHD1","chr11","+",6570008,6571423,6570008,6570396,6570617,6571423,1477,"13,16","9,0","5,0","0,0",298,149,1,1,"0.419,1.0","1.0,NA",-0.29]
[1487,"ENSG00000151093.7","OXSM","chr3","+",25790989,25791997,25790989,25791696,25791945,25791997,1487,269213,"0,3",337307,"0,1",298,149,1,1,"1.0,0.973","1.0,0.994",-0.011]
[1502,"ENSG00000135535.16","CD164","chr6","-",109366513,109369017,109366513,109368325,109368921,109369017,1502,1355411622,"17,4",1084810959,"0,0",298,149,1,1,"0.997,0.999","1.0,1.0",-2E-3]
[1520,"ENSG00000156508.17","EEF1A1","chr6","-",73518931,73519516,73518931,73519228,73519336,73519516,1520,686603,165991163224,440375,187402184887,257,149,1,1,"0.002,0.002","0.001,0.001",1E-3]
[1532,"ENSG00000112146.16","FBXO9","chr6","+",53092733,53093561,53092733,53092824,53093465,53093561,1532,236197,447360,344282,455389,298,149,0.0116982624109,0.0259627011878954,"0.209,0.215","0.274,0.266",-0.058]
[1540,"ENSG00000178821.12","TMEM52","chr1","-",1918252,1918934,1918252,1918431,1918892,1918934,1540,"5,1","1,6","1,0","0,1",298,149,0.0700618718947,0.125830273330943,"0.714,0.077","1.0,0.0",-0.105]
[1551,"ENSG00000112659.13","CUL9","chr6","+",43196068,43196862,43196068,43196265,43196644,43196862,1551,"81,61",125123,"75,89","39,30",298,149,{"v":1.14837805931e-10,"d":"1.15E-10"},{"v":7.57865631630869e-10,"d":"7.58E-10"},"0.245,0.199","0.49,0.597",-0.322]
[1561,"ENSG00000117593.10","DARS2","chr1","+",173826686,173828399,173826686,173826786,173828332,173828399,1561,"12,2",439307,"13,23",116157,298,149,{"v":1.12013109899e-09,"d":"1.12E-09"},{"v":6.63548322685087e-09,"d":"6.64E-09"},"0.013,0.003","0.053,0.068",-0.052]
[1573,"ENSG00000065029.14","ZNF76","chr6","+",35286127,35286399,35286127,35286208,35286321,35286399,1573,"35,25",154151,"28,19",168172,262,149,0.12554657177,0.209981841046404,"0.114,0.086","0.087,0.059",0.027]
[1581,"ENSG00000115459.17","ELMOD3","chr2","+",85355075,85357252,85355075,85355170,85356966,85357252,1581,"49,40","7,8","22,24","4,9",298,149,0.291654726469,0.432604462986997,"0.778,0.714","0.733,0.571",0.094]
[1592,"ENSG00000204469.12","PRRC2A","chr6","+",31637233,31637771,31637233,31637324,31637445,31637771,1592,"9,18",13421165,"24,41",716750,270,149,{"v":1.79742029882E-6,"d":"1.80E-06"},{"v":7.50771066716628e-06,"d":"7.51E-06"},"0.004,0.008","0.018,0.029",-0.018]
[1602,"ENSG00000213780.10","GTF2H4","chr6","+",30911683,30912146,30911683,30911767,30912013,30912146,1602,"65,45",307272,"14,28",223264,298,149,1.22745882666E-4,0.000385459439609642,"0.096,0.076","0.03,0.05",0.046]
[1616,"ENSG00000196839.12","ADA","chr20","-",44622828,44623078,44622828,44622930,44623006,44623078,1616,"26,10",147121,"26,22","15,16",225,149,{"v":2.22044604925E-16,"d":"2.22E-16"},{"v":2.37297669002055e-15,"d":"2.37E-15"},"0.105,0.052","0.534,0.477",-0.427]
[1618,"ENSG00000239665.8","AL157392.3","chr10","+",13654352,13655482,13654352,13654427,13655377,13655482,1618,"6,5","20,10","23,27","23,24",298,149,0.00416986378167,0.0101570860595606,"0.13,0.2","0.333,0.36",-0.182]
[1636,"ENSG00000160789.19","LMNA","chr1","+",156137653,156138757,156137653,156137743,156138487,156138757,1636,"81,50",128114,133112,"57,74",298,149,{"v":1.05255149041E-9,"d":"1.05E-09"},{"v":6.24294602749431E-9,"d":"6.24E-09"},"0.24,0.18","0.538,0.431",-0.275]
[1645,"ENSG00000117139.17","KDM5B","chr1","-",202730908,202731939,202730908,202731063,202731827,202731939,1645,"7,3",381332,"10,5",304306,298,149,0.852200826403,0.999676865582752,"0.009,0.004","0.016,0.008",-0.006]
[1654,"ENSG00000112739.16","PRPF4B","chr6","+",4060412,4062299,4060412,4060686,4061654,4062299,1654,15791408,"3,0",15091564,"8,6",298,149,1,1,"0.996,1.0","0.99,0.992",0.007]
[1665,"ENSG00000100888.13","CHD8","chr14","-",21394911,21395892,21394911,21395119,21395816,21395892,1665,"13,16","0,0","76,93","29,28",298,149,{"v":1.58820390395E-7,"d":"1.59E-07"},{"v":7.49853484999278e-07,"d":"7.50E-07"},"1.0,1.0","0.567,0.624",0.405]
[1679,"ENSG00000088826.17","SMOX","chr20","+",4182088,4182848,4182088,4182323,4182482,4182848,1679,"73,67","0,12",171175,"0,0",298,149,{"v":1.11782413142E-5,"d":"1.12E-05"},{"v":4.1633245711051e-05,"d":"4.16E-05"},"1.0,0.736","1.0,1.0",-0.132]
[1688,"ENSG00000048140.17","TSPAN17","chr5","+",176652742,176655020,176652742,176652913,176654894,176655020,1688,"25,26",97114,"57,57",95124,298,149,0.000268185443059,0.000800843251928857,"0.114,0.102","0.231,0.187",-0.101]
[1700,"ENSG00000137221.14","TJAP1","chr6","+",43500743,43501687,43500743,43500772,43501525,43501687,1700,"57,59",210193,101104,224233,298,149,0.00725016771491,0.0168554854518608,"0.119,0.133","0.184,0.182",-0.057]
[1713,"ENSG00000041357.15","PSMA4","chr15","+",78542176,78542645,78542176,78542219,78542575,78542645,1713,30922761,"78,98",13851520,"52,41",298,149,0.757319374362,0.916704191670329,"0.952,0.934","0.93,0.949",0.004]
[1723,"ENSG00000092929.11","UNC13D","chr17","-",75839838,75840329,75839838,75839942,75840224,75840329,1723,241248,"6,4",419503,"56,41",298,149,{"v":9.5097769659e-09,"d":"9.51E-09"},{"v":5.22872441520225e-08,"d":"5.23E-08"},"0.953,0.969","0.789,0.86",0.136]
[1730,"ENSG00000117616.17","RSRP1","chr1","-",25243549,25245301,25243549,25243633,25245149,25245301,1730,15431345,336352,243225,12431275,298,149,0,0,"0.697,0.656","0.089,0.081",0.592]
[1742,"ENSG00000170445.13","HARS","chr5","-",140677654,140679127,140677654,140677753,140679061,140679127,1742,264287,"0,0",215209,"2,1",298,149,1,1,"1.0,1.0","0.982,0.991",0.014]
[1755,"ENSG00000137411.17","VARS2","chr6","+",30923352,30924560,30923352,30923505,30924353,30924560,1755,"4,0",304351,"5,5",261208,298,149,1,1,"0.007,0.0","0.009,0.012",-0.007]
[1770,"ENSG00000168010.10","ATG16L2","chr11","+",72822847,72824842,72822847,72822961,72824733,72824842,1770,141145,"2,0","115,87","0,1",298,149,1,1,"0.972,1.0","1.0,0.978",-0.003]
[1784,"ENSG00000140553.17","UNC45A","chr15","+",90935945,90936460,90935945,90935982,90936284,90936460,1784,"24,13",402423,"56,28",382442,298,149,1.55357083465E-4,0.000476823648797817,"0.029,0.015","0.068,0.031",-0.028]
[1796,"ENSG00000185513.16","L3MBTL1","chr20","+",43530283,43532924,43530283,43530419,43532772,43532924,1796,"36,29","7,5","41,22","0,1",298,149,1,1,"0.72,0.744","1.0,0.917",-0.227]
[1811,"ENSG00000070756.15","PABPC1","chr8","-",100717772,100718280,100717772,100717888,100718230,100718280,1811,76147343,193163,56305448,129104,298,149,0.344071167566,0.497597589180332,"0.952,0.957","0.956,0.963",-0.005]
[1821,"ENSG00000172262.11","ZNF131","chr5","+",43161248,43161931,43161248,43161613,43161708,43161931,1821,376328,"94,50",230210,103103,244,149,{"v":1.15036301052E-6,"d":"1.15E-06"},{"v":4.90869827780341e-06,"d":"4.91E-06"},"0.71,0.8","0.577,0.555",0.189]
[1825,"ENSG00000161914.9","ZNF653","chr19","-",11486986,11487903,11486986,11487158,11487291,11487903,1825,"6,13","7,16","10,4","5,6",282,149,0.550487840993,0.721237666372852,"0.312,0.3","0.514,0.26",-0.081]
[1836,"ENSG00000198930.12","CSAG1","chrX","-",152727483,152728224,152727483,152727863,152728073,152728224,1836,"22,16","43,56","23,28","45,64",298,149,0.455814995783,0.623477127411454,"0.204,0.125","0.204,0.179",-0.027]
[1848,"ENSG00000197989.14","SNHG12","chr1","-",28579532,28579981,28579532,28579587,28579911,28579981,1848,12561094,207192,924909,185188,298,149,0.158084755808,0.256822846513497,"0.752,0.74","0.714,0.707",0.036]
[1858,"ENSG00000151651.15","ADAM8","chr10","-",133273253,133273838,133273253,133273443,133273761,133273838,1858,"3,3","5,9","2,11","22,16",298,149,0.669778294502,0.833927580008394,"0.231,0.143","0.043,0.256",0.038]
[1875,"ENSG00000142546.13","NOSIP","chr19","-",49556548,49556993,49556548,49556657,49556874,49556993,1875,635729,"5,7",535633,"0,2",298,149,0.31336226983,0.460056921517125,"0.984,0.981","1.0,0.994",-0.015]
[1884,"ENSG00000213523.10","SRA1","chr5","-",140551060,140552184,140551060,140551169,140551981,140552184,1884,"13,13",257252,"26,34",137140,298,149,{"v":1.22678802672E-8,"d":"1.23E-08"},{"v":6.6451018114e-08,"d":"6.65E-08"},"0.025,0.025","0.087,0.108",-0.073]
[1897,"ENSG00000183323.12","CCDC125","chr5","-",69320236,69320580,69320236,69320345,69320464,69320580,1897,"71,43","42,8","68,58","19,17",268,149,0.525149382058,0.697601852705825,"0.484,0.749","0.666,0.655",-0.044]
[1907,"ENSG00000213658.11","LAT","chr16","+",28986539,28986714,28986539,28986569,28986656,28986714,1907,647648,25012603,539533,16962019,236,149,0.235759708775,0.361097423543374,"0.14,0.136","0.167,0.143",-0.017]
[1910,"ENSG00000149761.8","NUDT22","chr11","+",64226289,64227132,64226289,64226427,64226634,64227132,1910,"41,49",134110,90128,"60,49",298,149,{"v":9.97646409928e-13,"d":"9.98E-13"},{"v":8.11978081493715e-12,"d":"8.12E-12"},"0.133,0.182","0.429,0.566",-0.34]
[1925,"ENSG00000161265.14","U2AF1L4","chr19","-",35742528,35743904,35742528,35742803,35743808,35743904,1925,"43,46",96103,151135,"48,70",298,149,{"v":1.82076576039E-14,"d":"1.82E-14"},{"v":1.69402618295108E-13,"d":"1.69E-13"},"0.183,0.183","0.611,0.491",-0.368]
[1936,"ENSG00000198755.10","RPL10A","chr6","+",35468946,35469529,35468946,35469285,35469380,35469529,1936,10501243,"105,77",17052021,"73,76",244,149,{"v":5.75717015305e-06,"d":"5.76E-06"},{"v":2.240998554243e-05,"d":"2.24E-05"},"0.859,0.908","0.934,0.942",-0.054]
[1948,"ENSG00000185627.17","PSMD13","chr11","+",244040,244469,244040,244075,244425,244469,1948,"109,91","0,1",180204,"3,1",298,149,0.623532051828,0.789887498022441,"1.0,0.978","0.968,0.99",0.01]
[1960,"ENSG00000164111.14","ANXA5","chr4","-",121696580,121696975,121696580,121696624,121696862,121696975,1960,"6,1",316345,"0,1",224382,298,149,1,1,"0.009,0.001","0.0,0.001",0.004]
[1969,"ENSG00000164073.10","MFSD8","chr4","-",127920556,127921771,127920556,127920836,127921523,127921771,1969,"64,68","31,40","37,20","65,60",298,149,{"v":2.42379849524e-09,"d":"2.42E-09"},{"v":1.40255169023339e-08,"d":"1.40E-08"},"0.508,0.459","0.222,0.143",0.301]
[1988,"ENSG00000138750.14","NUP54","chr4","-",76117663,76118194,76117663,76117774,76118074,76118194,1988,"49,50",598522,"75,67",349302,298,149,{"v":1.30101142637E-7,"d":"1.30E-07"},{"v":6.25991609744731e-07,"d":"6.26E-07"},"0.039,0.046","0.097,0.1",-0.056]
[1998,"ENSG00000127419.16","TMEM175","chr4","+",948115,948615,948115,948154,948410,948615,1998,"102,81","3,11",140140,"12,7",298,149,0.954957914308,1,"0.944,0.786","0.854,0.909",-0.016]
[2001,"ENSG00000109670.14","FBXW7","chr4","-",152534940,152536063,152534940,152535033,152535126,152536063,2001,"53,52","44,36","46,57","51,38",242,149,0.622072692682,0.788601369697058,"0.426,0.471","0.357,0.48",0.03]
[2012,"ENSG00000213024.11","NUP62","chr19","-",49927693,49929504,49927693,49927848,49929325,49929504,2012,408362,92111,200189,"48,36",298,149,0.240667741949,0.367192423005789,"0.689,0.62","0.676,0.724",-0.045]
[2021,"ENSG00000158850.14","B4GALT3","chr1","-",161176433,161177106,161176433,161176579,161176911,161177106,2021,"62,57","43,37","17,4","3,0",298,149,0.00399484189685,0.00980120206853839,"0.419,0.435","0.739,1.0",-0.442]
[2035,"ENSG00000099956.19","SMARCB1","chr22","+",23800943,23803422,23800943,23801135,23803294,23803422,2035,"6,12","40,35","8,7","30,29",298,149,0.887544396565,1,"0.07,0.146","0.118,0.108",-0.005]
[2051,"ENSG00000151632.17","AKR1C2","chr10","-",4999199,5000666,4999199,4999277,5000549,5000666,2051,"0,0","2,0","0,9","0,1",298,149,1,1,"0.0,NA","NA,0.818",-0.818]
[2067,"ENSG00000163682.16","RPL9","chr4","-",39458193,39458440,39458193,39458309,39458393,39458440,2067,"41,48",1104511579,"21,43",1421917620,233,149,1,1,"0.002,0.003","0.001,0.002",1E-3]
[2081,"ENSG00000169045.17","HNRNPH1","chr5","-",179616125,179617110,179616125,179616218,179617020,179617110,2081,16271534,144161,881936,835912,298,149,0,0,"0.85,0.827","0.345,0.339",0.497]
[2082,"ENSG00000169045.17","HNRNPH1","chr5","-",179616868,179617110,179616868,179616958,179617050,179617110,2082,16621587,54735177,10471237,17061716,241,149,{"v":1.53654866608e-13,"d":"1.54E-13"},{"v":1.33046047820248e-12,"d":"1.33E-12"},"0.158,0.159","0.275,0.308",-0.133]
[2092,"ENSG00000237765.6","FAM200B","chr4","+",15686235,15687148,15686235,15686462,15686931,15687148,2092,164135,"2,5",376478,"0,0",298,149,0.0293378528482,0.0585646242173786,"0.976,0.931","1.0,1.0",-0.046]
[2102,"ENSG00000128815.19","WDFY4","chr10","+",48966525,48969248,48966525,48966673,48969063,48969248,2102,"31,37",75103,"11,5","5,2",298,149,0.000243906504832,7.30641644840808E-4,"0.171,0.152","0.524,0.556",-0.379]
[2112,"ENSG00000196911.10","KPNA5","chr6","+",116732135,116741866,116732135,116732368,116741505,116741866,2112,"45,49","18,10","56,65","1,1",298,149,{"v":1.34762603299E-8,"d":"1.35E-08"},{"v":7.24177296323618e-08,"d":"7.24E-08"},"0.556,0.71","0.966,0.97",-0.335]
[2121,"ENSG00000109736.14","MFSD10","chr4","-",2932599,2933209,2932599,2932758,2933105,2933209,2121,152192,208265,257289,136143,298,149,{"v":3.32589511487e-12,"d":"3.33E-12"},{"v":2.52906607693239e-11,"d":"2.53E-11"},"0.268,0.266","0.486,0.503",-0.227]
[2130,"ENSG00000006047.12","YBX2","chr17","-",7291092,7292059,7291092,7291182,7292025,7292059,2130,"3,7","0,6","2,1","0,0",298,149,0.000922727513303,2.51051723086165E-3,"1.0,0.368","1.0,1.0",-0.316]
[2151,"ENSG00000104522.15","TSTA3","chr8","-",143614319,143614697,143614319,143614453,143614623,143614697,2151,"39,45",311278,"22,17","77,88",298,149,0.0498557775787,0.0929896480388881,"0.059,0.075","0.125,0.088",-0.039]
[2167,"ENSG00000161204.11","ABCF3","chr3","+",184187663,184187983,184187663,184187761,184187860,184187983,2167,"36,25",230239,"91,98",173158,248,149,{"v":7.77156117238e-16,"d":"7.77E-16"},{"v":7.96459130949095e-15,"d":"7.96E-15"},"0.086,0.059","0.24,0.271",-0.183]
[2168,"ENSG00000161204.11","ABCF3","chr3","+",184189087,184189277,184189087,184189144,184189254,184189277,2168,"10,29",209246,"20,20",161154,259,149,0.128279686816,0.213772931058288,"0.027,0.064","0.067,0.07",-0.023]
[2177,"ENSG00000145191.13","EIF2B5","chr3","+",184143051,184143565,184143051,184143142,184143430,184143565,2177,315290,"5,7",246248,"3,1",298,149,0.0491563556381,0.0918656587250037,"0.969,0.954","0.976,0.992",-0.022]
[2187,"ENSG00000204628.11","RACK1","chr5","-",181236928,181237719,181236928,181237042,181237608,181237719,2187,236202,1012410558,293386,816210487,298,149,{"v":5.82646360425e-06,"d":"5.83E-06"},{"v":2.26611227886608e-05,"d":"2.27E-05"},"0.012,0.009","0.018,0.018",-0.007]
[2196,"ENSG00000187796.14","CARD9","chr9","-",136364482,136365217,136364482,136364559,136365140,136365217,2196,350403,396396,313323,129178,298,149,{"v":1.00611631249E-8,"d":"1.01E-08"},{"v":5.51272737039844e-08,"d":"5.51E-08"},"0.306,0.337","0.548,0.476",-0.191]
[2212,"ENSG00000114859.15","CLCN2","chr3","-",184355693,184357094,184355693,184355844,184356992,184357094,2212,"16,24","2,0","52,44","3,7",298,149,0.0404100982762,0.0776580721192605,"0.8,1.0","0.897,0.759",0.072]
[2223,"ENSG00000164068.15","RNF123","chr3","+",49705533,49706065,49705533,49705679,49705981,49706065,2223,"59,45",222253,145131,"17,40",298,149,0,0,"0.117,0.082","0.81,0.621",-0.616]
[2241,"ENSG00000243989.8","ACY1","chr3","+",51986604,51987453,51986604,51986661,51986987,51987453,2241,"16,21",220165,"25,16","57,57",298,149,{"v":1.81460135473e-06,"d":"1.81E-06"},{"v":7.56615415482763E-6,"d":"7.57E-06"},"0.035,0.06","0.18,0.123",-0.104]
[2252,"ENSG00000109184.14","DCUN1D4","chr4","+",51886567,51887244,51886567,51886638,51887122,51887244,2252,"40,50","10,0","4,33","0,1",298,149,0.00469046356036,0.0113090699156037,"0.667,1.0","1.0,0.943",-0.138]
[2253,"ENSG00000149243.15","KLHL35","chr11","-",75425392,75426638,75425392,75425581,75426519,75426638,2253,"8,16","21,21","10,12","6,8",298,149,0.0211531820269,0.0437540752910377,"0.16,0.276","0.455,0.429",-0.224]
[2266,"ENSG00000164896.19","FASTK","chr7","-",151077309,151077780,151077309,151077401,151077620,151077780,2266,"132,83",256317,138202,238277,298,149,0.000471123431055,0.00135156026623698,"0.205,0.116","0.225,0.267",-0.085]
[2273,"ENSG00000169733.11","RFNG","chr17","-",82047901,82049116,82047901,82048807,82049030,82049116,2273,"16,10",213224,"14,39",209171,298,149,1.02956258407E-3,0.00277888194619576,"0.036,0.022","0.032,0.102",-0.038]
[2282,"ENSG00000169714.16","CNBP","chr3","-",129171078,129171538,129171078,129171280,129171445,129171538,2282,146149,12091149,"74,88",10731009,298,149,0.000800271016638,0.0022128706141884,"0.057,0.061","0.033,0.042",0.021]
[2295,"ENSG00000138035.14","PNPT1","chr2","-",55644636,55645432,55644636,55644720,55645348,55645432,2295,"81,69",900718,"102,88",532505,298,149,{"v":9.45079882619e-06,"d":"9.45E-06"},{"v":3.56187771487462e-05,"d":"3.56E-05"},"0.043,0.046","0.087,0.08",-0.039]
[2310,"ENSG00000104731.13","KLHDC4","chr16","-",87755193,87756477,87755193,87755292,87756398,87756477,2310,"30,33","99,69","17,8","3,7",298,149,0.00123835732716,0.00329003668386013,"0.132,0.193","0.739,0.364",-0.389]
[2325,"ENSG00000113460.12","BRIX1","chr5","+",34922216,34923234,34922216,34922287,34923132,34923234,2325,"74,33","0,0",168178,"0,1",298,149,1,1,"1.0,1.0","1.0,0.989",0.006]
[2336,"ENSG00000157379.13","DHRS1","chr14","-",24291138,24291625,24291138,24291219,24291555,24291625,2336,"31,33","24,39","41,39","17,22",298,149,0.0165576615697,0.0351998674499222,"0.392,0.297","0.547,0.47",-0.164]
[2337,"ENSG00000157379.13","DHRS1","chr14","-",24292183,24292784,24292183,24292330,24292651,24292784,2337,"14,25","43,42","37,27","13,11",298,149,{"v":1.82940029791e-08,"d":"1.83E-08"},{"v":9.74242919594046e-08,"d":"9.74E-08"},"0.14,0.229","0.587,0.551",-0.384]
[2360,"ENSG00000214279.13","SCART1","chr10","+",133464605,133465174,133464605,133464930,133465105,133465174,2360,"42,79","2,0","74,81","0,0",298,149,0.724315418209,0.887393921869792,"0.913,1.0","1.0,1.0",-0.043]
[2372,"ENSG00000198585.11","NUDT16","chr3","+",131383161,131388830,131383161,131383272,131383343,131388830,2372,189191,"7,0","117,99","2,1",220,149,0.404311810206,0.566418523598308,"0.948,1.0","0.975,0.985",-0.006]
[2382,"ENSG00000100949.14","RABGGTA","chr14","-",24268513,24268826,24268513,24268619,24268724,24268826,2382,"29,27",138161,"31,25","87,95",254,149,0.0362302550936,0.0705427002130209,"0.11,0.09","0.173,0.134",-0.053]
[2395,"ENSG00000110172.11","CHORDC1","chr11","-",90210535,90214175,90210535,90210594,90214017,90214175,2395,95103,"0,0",151129,"8,6",298,149,{"v":4.47580991617e-05,"d":"4.48E-05"},0.000150836065711837,"1.0,1.0","0.904,0.915",0.091]
[2411,"ENSG00000054118.14","THRAP3","chr1","+",36303795,36305357,36303795,36303831,36304473,36305357,2411,23962315,"8,11",25612891,"9,13",298,149,1,1,"0.993,0.991","0.993,0.991",0]
[2421,"ENSG00000143793.12","C1orf35","chr1","-",228102309,228102560,228102309,228102382,228102477,228102560,2421,"12,29",415436,"52,78",174230,244,149,0,0,"0.017,0.039","0.154,0.172",-0.135]
[2436,"ENSG00000111325.16","OGFOD2","chr12","+",122975810,122976767,122975810,122975867,122976600,122976767,2436,99156,"2,23",221233,"13,22",298,149,0.802330166271,0.955107034359231,"0.961,0.772","0.895,0.841",-1E-3]
[2437,"ENSG00000111325.16","OGFOD2","chr12","+",122975810,122976767,122975810,122975867,122976653,122976767,2437,99163,276406,246236,157150,298,149,0,0,"0.152,0.167","0.439,0.44",-0.28]
[2452,"ENSG00000126456.15","IRF3","chr19","-",49663187,49663514,49663187,49663258,49663342,49663514,2452,"51,81",543531,"62,88",375390,233,149,0.00414057972942,0.0100961206660318,"0.057,0.089","0.096,0.126",-0.038]
[2475,"ENSG00000142949.16","PTPRF","chr1","+",43620094,43620579,43620094,43620221,43620453,43620579,2475,"0,2","29,27","1,0","44,43",298,149,1,1,"0.0,0.036","0.011,0.0",0.012]
[2482,"ENSG00000009790.14","TRAF3IP3","chr1","+",209775348,209775736,209775348,209775489,209775598,209775736,2482,"34,34",230198,"21,13",190188,258,149,0.0136170412414,0.0296506178192965,"0.079,0.09","0.06,0.038",0.035]
[2492,"ENSG00000268758.7","ADGRE4P","chr19","-",6981079,6981770,6981079,6981215,6981726,6981770,2492,"33,24","1,0","42,55","3,4",298,149,0.00671743657391,0.0156938633890708,"0.943,1.0","0.875,0.873",0.098]
[2503,"ENSG00000163161.13","ERCC3","chr2","-",127289336,127289824,127289336,127289519,127289688,127289824,2503,111139,"17,25",291252,"31,45",298,149,0.488073301633,0.658676853313021,"0.766,0.735","0.824,0.737",-0.03]
[2507,"ENSG00000139998.15","RAB15","chr14","-",64950324,64951151,64950324,64950414,64951073,64951151,2507,"12,10","31,29","8,16","26,18",298,149,0.350063615936,0.504878984077908,"0.162,0.147","0.133,0.308",-0.066]
[2527,"ENSG00000142784.15","WDTC1","chr1","+",27303620,27305193,27303620,27303795,27305000,27305193,2527,"13,21",132182,"51,33",126148,298,149,{"v":6.9231462515e-06,"d":"6.92E-06"},{"v":2.66642280546814e-05,"d":"2.67E-05"},"0.047,0.055","0.168,0.1",-0.083]
[2528,"ENSG00000142784.15","WDTC1","chr1","+",27303620,27305193,27303620,27303795,27305058,27305193,2528,"64,73","1,3","99,85","2,2",298,149,0.756241938293,0.915909670102145,"0.97,0.924","0.961,0.955",-0.011]
[2537,"ENSG00000137955.15","RABGGTB","chr1","+",75789158,75790517,75789158,75789356,75790445,75790517,2537,336363,"0,0",789984,"0,1",298,149,1,1,"1.0,1.0","1.0,0.998",1E-3]
[2556,"ENSG00000127603.25","MACF1","chr1","+",39484600,39486987,39484600,39484730,39485537,39486987,2556,"80,79",745641,"59,58",566596,298,149,0.410096095088,0.572830724519446,"0.051,0.058","0.05,0.046",0.006]
[2563,"ENSG00000197343.10","ZNF655","chr7","+",99561887,99562494,99561887,99561973,99562367,99562494,2563,115127,111122,145131,"7,6",298,149,0,0,"0.341,0.342","0.912,0.916",-0.573]
[2579,"ENSG00000115355.16","CCDC88A","chr2","-",55332130,55332693,55332130,55332432,55332565,55332693,2579,"9,23","0,1","22,29","1,2",282,149,1,1,"1.0,0.924","0.921,0.885",0.059]
[2592,"ENSG00000152332.15","UHMK1","chr1","+",162499954,162501104,162499954,162500247,162500912,162501104,2592,"26,20",258257,"32,31",540397,298,149,0.249043782827,0.378754086382729,"0.048,0.037","0.029,0.038",0.009]
[2601,"ENSG00000248323.6","LUCAT1","chr5","-",91314079,91314377,91314079,91314247,91314331,91314377,2601,"1,0","0,0","8,3","0,1",233,149,1,1,"1.0,NA","1.0,0.657",0.171]
[2634,"ENSG00000114021.11","NIT2","chr3","+",100345584,100346255,100345584,100345678,100346180,100346255,2634,333305,380411,"21,12","63,62",298,149,{"v":6.64376228476e-08,"d":"6.64E-08"},{"v":3.31070681688875E-7,"d":"3.31E-07"},"0.305,0.271","0.143,0.088",0.173]
[2635,"ENSG00000168137.15","SETD5","chr3","+",9474448,9475156,9474448,9474582,9475067,9475156,2635,"109,81",582494,"45,70",650746,298,149,{"v":1.42861549179E-6,"d":"1.43E-06"},{"v":6.02558267426093e-06,"d":"6.03E-06"},"0.086,0.076","0.033,0.045",0.042]
[2656,"ENSG00000147789.15","ZNF7","chr8","+",144829042,144829604,144829042,144829090,144829444,144829604,2656,"58,55","2,5","59,56","2,6",298,149,0.835090382927,0.985697479350401,"0.935,0.846","0.937,0.824",0.01]
[2673,"ENSG00000160766.14","GBAP1","chr1","-",155215562,155215787,155215562,155215651,155215761,155215787,2673,"138,83","20,18","34,38","1,0",259,149,{"v":1.85804817776e-06,"d":"1.86E-06"},{"v":7.74050799251202e-06,"d":"7.74E-06"},"0.799,0.726","0.951,1.0",-0.213]
[2677,"ENSG00000158796.16","DEDD","chr1","-",161124137,161124526,161124137,161124210,161124413,161124526,2677,402380,"19,14",453450,"4,5",298,149,{"v":2.25134282779e-05,"d":"2.25E-05"},{"v":7.99597433971822e-05,"d":"8.00E-05"},"0.914,0.931","0.983,0.978",-0.058]
[2688,"ENSG00000256269.8","HMBS","chr11","+",119088634,119089131,119088634,119088707,119089081,119089131,2688,"73,41",941922,187214,602688,298,149,0,0,"0.037,0.022","0.134,0.135",-0.105]
[2698,"ENSG00000239779.6","WBP1","chr2","+",74459437,74459745,74459437,74459562,74459642,74459745,2698,"75,57","30,35","95,57","9,6",229,149,{"v":1.49065603416e-07,"d":"1.49E-07"},{"v":7.0731628820892e-07,"d":"7.07E-07"},"0.619,0.514","0.873,0.861",-0.3]
[2702,"ENSG00000143624.13","INTS3","chr1","+",153773192,153774808,153773192,153773331,153774517,153774808,2702,"71,48","5,14","71,61","13,13",298,149,0.568157281978,0.737190676233418,"0.877,0.632","0.732,0.701",0.038]
[2721,"ENSG00000213930.11","GALT","chr9","+",34647088,34647567,34647088,34647258,34647491,34647567,2721,"51,36",108124,"19,22","4,6",298,149,{"v":4.38182823359E-12,"d":"4.38E-12"},{"v":3.29505150053637e-11,"d":"3.30E-11"},"0.191,0.127","0.704,0.647",-0.516]
[2722,"ENSG00000213930.11","GALT","chr9","+",34647088,34647567,34647088,34647258,34647540,34647567,2722,"89,86","0,4","26,25","14,8",298,149,{"v":6.25183904646e-10,"d":"6.25E-10"},{"v":3.80808424588609e-09,"d":"3.81E-09"},"1.0,0.915","0.481,0.61",0.412]
[2732,"ENSG00000213930.11","GALT","chr9","+",34648761,34649081,34648761,34648907,34648997,34649081,2732,"45,39","4,1","28,42","0,0",239,149,0.0154286936331,0.0331413088678404,"0.875,0.96","1.0,1.0",-0.083]
[2754,"ENSG00000124006.14","OBSL1","chr2","-",219552535,219553024,219552535,219552697,219552867,219553024,2754,"12,3","0,2","21,18","0,0",298,149,0.381157464105,0.540200766779637,"1.0,0.429","1.0,1.0",-0.285]
[2760,"ENSG00000106397.11","PLOD3","chr7","-",101212841,101213204,101212841,101212943,101213106,101213204,2760,"4,9",161173,"12,9",167153,298,149,0.137824412726,0.227154164079496,"0.012,0.025","0.035,0.029",-0.013]
[2771,"ENSG00000197102.11","DYNC1H1","chr14","+",102015855,102016999,102015855,102016489,102016765,102016999,2771,"7,17",445461,"24,15",311311,298,149,1.90659219177E-3,0.00494274001952422,"0.008,0.018","0.037,0.024",-0.018]
[2781,"ENSG00000014914.20","MTMR11","chr1","-",149930364,149930965,149930364,149930547,149930791,149930965,2781,"2,7","4,2","4,2","5,17",298,149,0.0628190930759,0.114249366287905,"0.2,0.636","0.286,0.056",0.247]
[2793,"ENSG00000178104.19","PDE4DIP","chr1","+",148991884,148993882,148991884,148991973,148993484,148993882,2793,"5,5","0,0","2,4","1,0",298,149,1,1,"1.0,1.0","0.5,1.0",0.25]
[2799,"ENSG00000153187.19","HNRNPU","chr1","-",244859274,244862381,244859274,244859374,244860357,244862381,2799,23071937,"52,19",870991,"25,21",298,149,0.0799353944149,0.141263853444581,"0.957,0.981","0.946,0.959",0.017]
[2805,"ENSG00000173171.14","MTX1","chr1","+",155210547,155212219,155210547,155210627,155212126,155212219,2805,"71,76",459514,95129,337404,298,149,{"v":6.34419498302e-06,"d":"6.34E-06"},{"v":2.45540009742495e-05,"d":"2.46E-05"},"0.072,0.069","0.124,0.138",-0.06]
[2814,"ENSG00000166986.14","MARS","chr12","+",57515919,57516337,57515919,57516158,57516244,57516337,2814,259224,"4,5",253256,"5,2",235,149,0.51573891247,0.687410432491615,"0.976,0.966","0.97,0.988",-0.008]
[2825,"ENSG00000183856.10","IQGAP3","chr1","-",156525404,156526599,156525404,156525552,156526222,156526599,2825,352317,"3,4",233260,"0,0",298,149,0.487324891003,0.658200183818286,"0.983,0.975","1.0,1.0",-0.021]
[2841,"ENSG00000136450.12","SRSF1","chr17","-",58004922,58005973,58004922,58005041,58005800,58005973,2841,32492735,138113,29233050,101149,298,149,0.960913047239,1,"0.922,0.924","0.935,0.911",0]
[2852,"ENSG00000169242.11","EFNA1","chr1","+",155133502,155133780,155133502,155133568,155133729,155133780,2852,"3,4","3,10","0,2","20,14",298,149,0.00180656657546,0.00469450076700859,"0.333,0.167","0.0,0.067",0.216]
[2867,"ENSG00000117385.15","P3H1","chr1","-",42746374,42747412,42746374,42746852,42747271,42747412,2867,207190,422405,"98,60",137145,298,149,0.430977737331,0.596380683474947,"0.197,0.19","0.263,0.171",-0.024]
[2879,"ENSG00000196497.16","IPO4","chr14","-",24188215,24188423,24188215,24188257,24188343,24188423,2879,"2,2",419488,"3,4",202188,235,149,1,1,"0.003,0.003","0.009,0.013",-0.008]
[2890,"ENSG00000163359.15","COL6A3","chr2","-",237342064,237344843,237342064,237342161,237344349,237344843,2890,"1,0","2,2","4,2","7,6",298,149,0.0140630857518,0.0305257739671962,"0.2,0.0","0.222,0.143",-0.082]
[2896,"ENSG00000164050.12","PLXNB1","chr3","-",48410454,48411036,48410454,48410558,48410867,48411036,2896,"1,2","0,5","0,3","0,10",298,149,1,1,"1.0,0.167","NA,0.13",0.454]
[2907,"ENSG00000115271.10","GCA","chr2","+",162359043,162359552,162359043,162359157,162359493,162359552,2907,"54,26",321272,209260,157199,298,149,0,0,"0.078,0.046","0.4,0.395",-0.336]
[2919,"ENSG00000100219.16","XBP1","chr22","-",28796046,28796192,28796046,28796121,28796147,28796192,2919,728675,"31,34",393330,"11,11",175,149,0.0774672547128,0.137568160034519,"0.952,0.944","0.968,0.962",-0.017]
[2933,"ENSG00000187621.14","TCL6","chr14","+",95668125,95669617,95668125,95668580,95669550,95669617,2933,"25,53","4,0","3,7","0,0",298,149,0.0598081738151,0.109233943322805,"0.758,1.0","1.0,1.0",-0.121]
[2946,"ENSG00000128596.16","CCDC136","chr7","+",128806236,128806858,128806236,128806395,128806687,128806858,2946,"21,19","17,13","23,20","1,4",298,149,0.000131729764124,0.000411222191294986,"0.382,0.422","0.92,0.714",-0.415]
[2958,"ENSG00000051523.10","CYBA","chr16","-",88646115,88646838,88646115,88646197,88646754,88646838,2958,135149,50225140,202225,56756821,298,149,0.115819151344,0.195504045936421,"0.013,0.014","0.017,0.016",-0.003]
[2969,"ENSG00000168936.10","TMEM129","chr4","-",1720632,1721331,1720632,1720945,1721029,1721331,2969,110151,"14,26",215245,"19,32",233,149,0.206337444541,0.322699793786105,"0.834,0.788","0.879,0.83",-0.044]
[2979,"ENSG00000133835.15","HSD17B4","chr5","+",119492099,119493946,119492099,119492124,119493817,119493946,2979,"38,37",663602,183176,526519,298,149,0,0,"0.028,0.03","0.148,0.145",-0.117]
[2991,"ENSG00000221978.11","CCNL2","chr1","-",1390765,1391575,1390765,1390865,1391296,1391575,2991,15391539,"7,15",13571433,"37,16",298,149,1.48139809939E-4,0.00045733467674727,"0.991,0.981","0.948,0.978",0.023]
[3004,"ENSG00000158793.13","NIT1","chr1","+",161119133,161119612,161119133,161119388,161119492,161119612,3004,"35,36","4,0","36,32","5,1",253,149,0.416977265896,0.580392234284693,"0.837,1.0","0.809,0.95",0.039]
[3019,"ENSG00000163702.19","IL17RC","chr3","+",9923880,9924291,9923880,9924020,9924231,9924291,3019,"11,12","19,19","5,10","29,17",298,149,0.139959066395,0.230272458406475,"0.224,0.24","0.079,0.227",0.079]
[3036,"ENSG00000084072.16","PPIE","chr1","+",39741894,39743297,39741894,39741921,39743215,39743297,3036,"40,29",13271423,"96,91",636797,298,149,0,0,"0.015,0.01","0.07,0.054",-0.05]
[3050,"ENSG00000013573.16","DDX11","chr12","+",31089402,31090094,31089402,31089490,31089839,31090094,3050,413332,"1,6",159164,"0,2",298,149,0.471076173388,0.641761826794734,"0.995,0.965","1.0,0.976",-0.008]
[3060,"ENSG00000162910.18","MRPL55","chr1","-",228108436,228109021,228108436,228108474,228108954,228109021,3060,165195,"29,25",341270,"47,38",298,149,0.751297631009,0.91174098699174,"0.74,0.796","0.784,0.78",-0.014]
[3073,"ENSG00000138496.16","PARP9","chr3","-",122536167,122537073,122536167,122536342,122536933,122537073,3073,"16,9","80,99","14,19","81,81",298,149,0.206270979612,0.322699793786105,"0.091,0.043","0.08,0.105",-0.025]
[3082,"ENSG00000010327.10","STAB1","chr3","+",52519504,52520120,52519504,52519564,52519943,52520120,3082,"3,3","23,22","9,5","53,42",298,149,0.635679978746,0.801568296345939,"0.061,0.064","0.078,0.056",-0.005]
[3087,"ENSG00000143499.13","SMYD2","chr1","+",214330949,214334308,214330949,214331070,214332017,214334308,3087,"86,86",199200,"37,30","45,25",298,149,0.00053180537541,0.00150741726781388,"0.178,0.177","0.291,0.375",-0.155]
[3098,"ENSG00000103496.14","STX4","chr16","+",31039722,31040168,31039722,31039818,31039911,31040168,3098,"23,8",313342,"16,25",236281,242,149,0.0506388328551,0.0943389328219275,"0.043,0.014","0.04,0.052",-0.018]
[3107,"ENSG00000189171.14","S100A13","chr1","-",153626319,153627598,153626319,153626533,153627482,153627598,3107,"95,74","48,67","39,68","23,15",298,149,0.0933598471015,0.162327766396708,"0.497,0.356","0.459,0.694",-0.15]
[3121,"ENSG00000135341.17","MAP3K7","chr6","-",90550467,90552179,90550467,90550549,90552048,90552179,3121,"47,23",453372,"59,80",368371,298,149,{"v":8.89778395885e-06,"d":"8.90E-06"},{"v":3.37087225080507e-05,"d":"3.37E-05"},"0.049,0.03","0.074,0.097",-0.046]
[3127,"ENSG00000188542.9","DUSP28","chr2","+",240561329,240564014,240561329,240561519,240563673,240564014,3127,"55,91","20,20",85100,"28,21",298,149,0.883541431458,1,"0.579,0.695","0.603,0.704",-0.016]
[3146,"ENSG00000169738.7","DCXR","chr17","-",82036190,82036643,82036190,82036448,82036543,82036643,3146,199197,13621325,268237,604633,244,149,{"v":4.4408920985E-16,"d":"4.44E-16"},{"v":4.62105987004002e-15,"d":"4.62E-15"},"0.082,0.083","0.213,0.186",-0.117]
[3160,"ENSG00000157191.19","NECAP2","chr1","+",16449092,16452015,16449092,16449201,16451837,16452015,3160,"14,14",238251,"25,12",206222,298,149,0.13552855873,0.223914697483931,"0.029,0.027","0.057,0.026",-0.014]
[3170,"ENSG00000143702.15","CEP170","chr1","-",243185778,243186422,243185778,243186072,243186258,243186422,3170,"12,14",243218,"36,17","70,66",298,149,{"v":5.06394925992e-12,"d":"5.06E-12"},{"v":3.7899746432682e-11,"d":"3.79E-11"},"0.024,0.031","0.205,0.114",-0.132]
[3174,"ENSG00000158769.17","F11R","chr1","-",161001019,161001353,161001019,161001127,161001284,161001353,3174,"2,1",137135,"7,3",169217,298,149,0.773959841261,0.929731505514796,"0.007,0.004","0.02,0.007",-0.008]
[3184,"ENSG00000154889.16","MPPE1","chr18","-",11885675,11887025,11885675,11885816,11886916,11887025,3184,"57,61","1,0","75,76","42,54",298,149,0,0,"0.966,1.0","0.472,0.413",0.54]
[3199,"ENSG00000099957.16","P2RX6","chr22","+",21026419,21028008,21026419,21026957,21027507,21028008,3199,"3,4","1,0","2,3","0,0",298,149,1,1,"0.6,1.0","1.0,1.0",-0.2]
[3209,"ENSG00000110888.17","CAPRIN2","chr12","-",30719078,30720915,30719078,30719225,30720810,30720915,3209,"47,45","84,79","28,42","24,13",298,149,1.0756257266E-3,0.00289169635847988,"0.219,0.222","0.368,0.618",-0.272]
[3214,"ENSG00000213983.11","AP1G2","chr14","-",23563583,23563856,23563583,23563609,23563715,23563856,3214,"53,50","4,9","66,48","9,12",255,149,0.307498520376,0.453080875964708,"0.886,0.764","0.811,0.7",0.069]
[3232,"ENSG00000198830.10","HMGN2","chr1","+",26473482,26474135,26473482,26473527,26474084,26474135,3232,940887,"8,7",902929,"0,0",298,149,0.287340883929,0.427006731676512,"0.983,0.984","1.0,1.0",-0.016]
[3243,"ENSG00000110011.13","DNAJC4","chr11","+",64233893,64234281,64233893,64233980,64234072,64234281,3243,151104,77105,160184,"105,90",241,149,0.331888042734,0.48270131110241,"0.548,0.38","0.485,0.558",-0.058]
[3262,"ENSG00000174748.20","RPL15","chr3","+",23917147,23918576,23917147,23917173,23918439,23918576,3262,"68,69","0,1","57,80","0,0",298,149,1,1,"1.0,0.972","1.0,1.0",-0.014]
[3266,"ENSG00000103126.14","AXIN1","chr16","-",289439,293718,289439,289607,293487,293718,3266,"10,5",224227,"22,13",252260,298,149,0.0170225394928,0.0360589062023821,"0.022,0.011","0.042,0.024",-0.017]
[3275,"ENSG00000013441.15","CLK1","chr2","-",200859679,200861466,200859679,200859746,200861237,200861466,3275,263277,221212,764822,292311,298,149,{"v":5.53291834571e-09,"d":"5.53E-09"},{"v":3.10694645566792e-08,"d":"3.11E-08"},"0.373,0.395","0.567,0.569",-0.184]
[3285,"ENSG00000007923.15","DNAJC11","chr1","-",6637446,6638364,6637446,6637504,6638294,6638364,3285,137129,1070874,97150,771771,298,149,0.295182477416,0.436744887851237,"0.06,0.069","0.059,0.089",-0.009]
[3295,"ENSG00000088836.13","SLC4A11","chr20","-",3229094,3229452,3229094,3229263,3229345,3229452,3295,"0,0","3,30","0,3","2,9",231,149,0.18544008594,0.295173836895437,"0.0,0.0","0.0,0.177",-0.088]
[3303,"ENSG00000072694.20","FCGR2B","chr1","+",161673959,161677365,161673959,161674073,161677327,161677365,3303,"1,0","1,0","0,4","0,1",298,149,1,1,"0.333,NA","NA,0.667",-0.334]
[3321,"ENSG00000021776.10","AQR","chr15","-",34873827,34874864,34873827,34873999,34874676,34874864,3321,"27,35",426328,"22,34",352344,298,149,0.898890131905,1,"0.031,0.051","0.03,0.047",2E-3]
[3335,"ENSG00000215788.10","TNFRSF25","chr1","-",6462862,6463147,6462862,6462970,6463064,6463147,3335,303270,"3,2",145130,"0,0",243,149,0.679356219548,0.842773572840155,"0.984,0.988","1.0,1.0",-0.014]
[3351,"ENSG00000012171.19","SEMA3B","chr3","+",50273534,50273828,50273534,50273646,50273758,50273828,3351,"0,1","0,1","0,0","1,0",261,149,1,1,"NA,0.363","0.0,NA",0.363]
[3354,"ENSG00000012171.19","SEMA3B","chr3","+",50275011,50275459,50275011,50275053,50275301,50275459,3354,"2,0","0,0","9,1","0,5",298,149,1,1,"1.0,NA","1.0,0.091",0.455]
[3366,"ENSG00000171530.13","TBCA","chr5","-",77691240,77693352,77691240,77691498,77693265,77693352,3366,"53,49",54075225,"17,12",33103582,298,149,1,1,"0.005,0.005","0.003,0.002",0.003]
[3376,"ENSG00000270629.5","NBPF14","chr1","-",148595542,148595890,148595542,148595752,148595854,148595890,3376,"11,18","17,23","16,22","4,0",251,149,{"v":2.67921206065e-06,"d":"2.68E-06"},{"v":1.08936257307491E-5,"d":"1.09E-05"},"0.278,0.317","0.704,1.0",-0.554]
[3385,"ENSG00000184009.11","ACTG1","chr17","-",81511187,81511803,81511187,81511626,81511762,81511803,3385,412432,"0,0",916950,"0,2",285,149,1,1,"1.0,1.0","1.0,0.996",2E-3]
[3393,"ENSG00000133056.13","PIK3C2B","chr1","-",204445955,204446144,204445955,204446002,204446086,204446144,3393,"61,55","2,0","64,58","0,6",233,149,0.103209050678,0.176732928714222,"0.951,1.0","1.0,0.861",0.045]
[3416,"ENSG00000073060.15","SCARB1","chr12","-",124782682,124786503,124782682,124782811,124786356,124786503,3416,220225,346360,309257,"72,95",298,149,0,0,"0.241,0.238","0.682,0.575",-0.389]
[3429,"ENSG00000187801.14","ZFP69B","chr1","+",40456944,40457439,40456944,40457071,40457343,40457439,3429,"1,1","8,4","21,27","17,18",298,149,{"v":8.21760751847e-05,"d":"8.22E-05"},0.000264715191277258,"0.059,0.111","0.382,0.429",-0.321]
[3443,"ENSG00000171703.16","TCEA2","chr20","+",64069764,64070635,64069764,64070414,64070488,64070635,3443,"3,4","78,57","30,23","37,40",223,149,{"v":2.93542967711e-13,"d":"2.94E-13"},{"v":2.49616735087579e-12,"d":"2.50E-12"},"0.025,0.045","0.351,0.278",-0.279]
[3449,"ENSG00000204257.14","HLA-DMA","chr6","-",32949610,32950803,32949610,32949787,32950518,32950803,3449,"48,45","9,1","25,22","0,4",298,149,0.497276023587,0.668566146498793,"0.727,0.957","1.0,0.733",-0.025]
[3459,"ENSG00000003509.15","NDUFAF7","chr2","+",37241577,37242693,37241577,37241791,37242634,37242693,3459,154161,"47,53",190250,"1,5",298,149,0,0,"0.621,0.603","0.99,0.962",-0.364]
[3471,"ENSG00000241370.5","RPP21","chr6","+",30345297,30345573,30345297,30345398,30345490,30345573,3471,"51,23",481498,"47,64",376411,241,149,6.9065514627E-4,1.92321518136804E-3,"0.062,0.028","0.072,0.088",-0.035]
[3494,"ENSG00000185920.15","PTCH1","chr9","-",95449840,95453620,95449840,95449940,95453477,95453620,3494,"9,7","46,49","12,24","28,39",298,149,0.000558926947332,0.00157769682634761,"0.089,0.067","0.176,0.235",-0.128]
[3512,"ENSG00000255717.6","SNHG1","chr11","-",62852810,62853590,62852810,62852839,62853551,62853590,3512,13471195,"0,1",649619,"0,0",298,149,1,1,"1.0,0.998","1.0,1.0",-1E-3]
[3523,"ENSG00000198720.12","ANKRD13B","chr17","+",29609085,29609421,29609085,29609275,29609354,29609421,3523,"3,4","94,69","9,12","60,75",228,149,0.00158293118361,0.00415202236939162,"0.02,0.037","0.089,0.095",-0.064]
[3531,"ENSG00000141425.17","RPRD1A","chr18","-",35989823,35993300,35989823,35990595,35993101,35993300,3531,580432,"9,16",410476,"16,11",298,149,0.497068545831,0.6685346513515,"0.97,0.931","0.928,0.956",0.009]
[3542,"ENSG00000142208.16","AKT1","chr14","-",104769351,104772452,104769351,104770420,104770744,104772452,3542,"51,46",904988,"52,74",556569,298,149,{"v":6.34033971048e-06,"d":"6.34E-06"},{"v":2.45540009742495e-05,"d":"2.46E-05"},"0.027,0.023","0.045,0.061",-0.028]
[3543,"ENSG00000142208.16","AKT1","chr14","-",104770744,104772452,104770744,104770847,104772364,104772452,3543,"65,72",11481250,"77,94",615668,298,149,{"v":6.13533659433e-08,"d":"6.14E-08"},{"v":3.06766829716499E-7,"d":"3.07E-07"},"0.028,0.028","0.059,0.066",-0.035]
[3559,"ENSG00000185813.10","PCYT2","chr17","-",81907553,81907857,81907553,81907598,81907772,81907857,3559,"34,27",336301,"23,22",167146,298,149,0.0953842413624,0.165362888295428,"0.048,0.043","0.064,0.07",-0.022]
[3567,"ENSG00000132781.17","MUTYH","chr1","-",45332917,45333324,45332917,45332959,45333284,45333324,3567,"96,90","0,3",142133,"9,17",298,149,{"v":7.58159194078e-05,"d":"7.58E-05"},0.000245560776511952,"1.0,0.938","0.887,0.796",0.127]
[3584,"ENSG00000174851.15","YIF1A","chr11","-",66284579,66284966,66284579,66284783,66284872,66284966,3584,"34,23",512560,"38,45",366495,238,149,0.00314386454153,0.007859661353825,"0.04,0.025","0.061,0.054",-0.025]
[3598,"ENSG00000143379.12","SETDB1","chr1","+",150962973,150963741,150962973,150963139,150963529,150963741,3598,"54,62",231238,"62,65",164163,298,149,0.0112754483786,0.0251655703464049,"0.105,0.115","0.159,0.166",-0.053]
[3614,"ENSG00000123066.8","MED13L","chr12","-",115980749,115982603,115980749,115980938,115982383,115982603,3614,"24,30",237189,"19,31",291296,298,149,0.0829002913383,0.146068281619098,"0.048,0.074","0.032,0.05",0.02]
[3624,"ENSG00000160753.15","RUSC1","chr1","+",155325863,155327132,155325863,155325910,155326897,155327132,3624,109152,"28,28",170157,"8,13",298,149,{"v":7.22563448985e-06,"d":"7.23E-06"},{"v":2.77616483031078e-05,"d":"2.78E-05"},"0.661,0.731","0.914,0.858",-0.19]
[3638,"ENSG00000092531.9","SNAP23","chr15","+",42512954,42513447,42512954,42512996,42513173,42513447,3638,"102,86","2,2",149207,"1,0",298,149,0.472235447928,0.642603154694109,"0.962,0.956","0.987,1.0",-0.035]
[3639,"ENSG00000092531.9","SNAP23","chr15","+",42512954,42513447,42512954,42512996,42513335,42513447,3639,"93,94","4,0",201247,"0,3",298,149,0.277254507855,0.414614761982973,"0.921,1.0","1.0,0.976",-0.027]
[3657,"ENSG00000008710.19","PKD1","chr16","-",2103265,2103895,2103265,2103390,2103515,2103895,3657,172175,"0,0",255306,"3,2",274,149,0.60213626063,0.770533051965844,"1.0,1.0","0.979,0.988",0.016]
[3663,"ENSG00000213316.9","LTC4S","chr5","+",179795583,179795856,179795583,179795683,179795785,179795856,3663,331409,342376,645774,426541,251,149,2.87811809848E-3,0.00722957669522901,"0.365,0.392","0.473,0.459",-0.087]
[3674,"ENSG00000171720.9","HDAC3","chr5","-",141629859,141630125,141629859,141629916,141630043,141630125,3674,"50,35",452537,"95,90",251248,276,149,0,0,"0.056,0.034","0.17,0.164",-0.122]
[3687,"ENSG00000164080.13","RAD54L2","chr3","+",51638143,51639670,51638143,51638321,51639418,51639670,3687,"39,15","80,92","19,21","97,93",298,149,0.169939768208,0.273158604385826,"0.196,0.075","0.089,0.101",0.041]
[3701,"ENSG00000160014.16","CALM3","chr19","+",46608481,46608981,46608481,46608588,46608845,46608981,3701,"103,67",48274538,"95,97",31823331,298,149,0.00887740125844,0.0203592406821159,"0.011,0.007","0.015,0.014",-0.005]
[3712,"ENSG00000129255.15","MPDU1","chr17","+",7586898,7587271,7586898,7587017,7587160,7587271,3712,"50,64",519446,"23,29","50,93",292,149,{"v":7.47641044518E-7,"d":"7.48E-07"},{"v":3.27870310188346e-06,"d":"3.28E-06"},"0.047,0.068","0.19,0.137",-0.106]
[3724,"ENSG00000172053.17","QARS","chr3","-",49098599,49098989,49098599,49098692,49098884,49098989,3724,173178,13881474,149186,736730,298,149,{"v":2.04007217963E-6,"d":"2.04E-06"},{"v":8.46906604754536e-06,"d":"8.47E-06"},"0.059,0.057","0.092,0.113",-0.045]
[3725,"ENSG00000172053.17","QARS","chr3","-",49099760,49100091,49099760,49099853,49099960,49100091,3725,"19,19",15961734,"101,79",865915,256,149,0,0,"0.007,0.006","0.064,0.048",-0.05]
[3746,"ENSG00000136718.9","IMP4","chr2","+",130346017,130346249,130346017,130346112,130346200,130346249,3746,"29,31",923941,"33,45",591715,237,149,0.00228959952226,0.00584408269667762,"0.019,0.02","0.034,0.038",-0.017]
[3753,"ENSG00000005302.18","MSL3","chrX","+",11763779,11765729,11763779,11763938,11765466,11765729,3753,"66,79",175132,92118,151163,298,149,0.045216226616,0.0854444425698606,"0.159,0.23","0.234,0.266",-0.055]
[3762,"ENSG00000198198.16","SZT2","chr1","+",43448611,43450171,43448611,43448728,43450102,43450171,3762,214116,227223,105110,182155,298,149,0.563361057446,0.733172851777638,"0.32,0.206","0.224,0.262",0.02]
[3771,"ENSG00000114388.12","NPRL2","chr3","-",50349664,50350022,50349664,50349828,50349930,50350022,3771,"38,38","52,34","42,48","19,30",251,149,0.00709612010313,0.0165297446683121,"0.303,0.399","0.568,0.487",-0.176]
[3782,"ENSG00000177685.16","CRACR2B","chr11","+",830865,831295,830865,831032,831223,831295,3782,"37,25","30,34","59,54","24,24",298,149,0.00140055117051,0.00370435635678369,"0.381,0.269","0.551,0.529",-0.215]
[3790,"ENSG00000101365.20","IDH3B","chr20","-",2660456,2660829,2660456,2660590,2660696,2660829,3790,181144,19141717,533594,11911338,255,149,0,0,"0.052,0.047","0.207,0.206",-0.157]
[3800,"ENSG00000112787.13","FBRSL1","chr12","+",132574318,132574564,132574318,132574348,132574492,132574564,3800,"64,54",726744,"34,22",308333,293,149,0.751251228046,0.91174098699174,"0.043,0.036","0.053,0.033",-0.004]
[3804,"ENSG00000123473.15","STIL","chr1","-",47299904,47300152,47299904,47299968,47300109,47300152,3804,335409,"59,56",662636,"30,28",290,149,{"v":5.32665023201e-11,"d":"5.33E-11"},{"v":3.66835346166726e-10,"d":"3.67E-10"},"0.745,0.79","0.919,0.921",-0.152]
[3829,"ENSG00000102125.15","TAZ","chrX","+",154419542,154419746,154419542,154419623,154419704,154419746,3829,"44,42","67,63","27,32","38,38",230,149,0.527765825597,0.700685182556733,"0.298,0.302","0.315,0.353",-0.034]
[3835,"ENSG00000171863.14","RPS7","chr2","+",3575357,3575684,3575357,3575448,3575600,3575684,3835,15291406,"66,69",16671872,130107,298,149,0.0105551230662,0.0237365208289663,"0.921,0.911","0.865,0.897",0.035]
[3846,"ENSG00000114786.16","ABHD14A-ACY1","chr3","+",51986414,51987624,51986414,51987453,51987555,51987624,3846,"5,12",382382,"6,5",96134,251,149,0.13116800895,0.217771939281927,"0.008,0.018","0.036,0.022",-0.016]
[3856,"ENSG00000164877.18","MICALL2","chr7","-",1440590,1442484,1440590,1440684,1442191,1442484,3856,276369,279267,167185,201215,298,149,0.0239943035029,0.0489690194069937,"0.331,0.409","0.293,0.301",0.073]
[3867,"ENSG00000164855.15","TMEM184A","chr7","-",1548518,1549945,1548518,1548688,1549853,1549945,3867,"0,0","4,4","6,0","0,1",298,149,0.0132206589949,0.0289487895389019,"0.0,0.0","1.0,0.0",-0.5]
[3872,"ENSG00000172009.14","THOP1","chr19","+",2807441,2808444,2807441,2807773,2808242,2808444,3872,151214,"0,0",144149,"8,4",298,149,{"v":6.34771500312e-05,"d":"6.35E-05"},0.000209311380749161,"1.0,1.0","0.9,0.949",0.076]
[3908,"ENSG00000084774.13","CAD","chr2","+",27242619,27242973,27242619,27242775,27242871,27242973,3908,"5,12",11111281,"14,5",434406,245,149,0.507389082073,0.678377344163534,"0.003,0.006","0.019,0.007",-0.008]
[3915,"ENSG00000104783.12","KCNN4","chr19","-",43766532,43767707,43766532,43767089,43767539,43767707,3915,"44,43",412454,159185,423344,298,149,0,0,"0.051,0.045","0.158,0.212",-0.137]
[3930,"ENSG00000163938.16","GNL3","chr3","+",52690591,52691071,52690591,52690704,52690944,52691071,3930,523469,17301655,493382,505569,298,149,{"v":4.4408920985E-16,"d":"4.44E-16"},{"v":4.62105987004002e-15,"d":"4.62E-15"},"0.131,0.124","0.328,0.251",-0.162]
[3940,"ENSG00000197448.13","GSTK1","chr7","+",143264991,143265296,143264991,143265092,143265260,143265296,3940,443457,890786,"70,94",283314,298,149,{"v":8.0572988248e-07,"d":"8.06E-07"},{"v":3.5107330508426e-06,"d":"3.51E-06"},"0.199,0.225","0.11,0.13",0.092]
[3951,"ENSG00000074582.13","BCS1L","chr2","+",218662196,218662679,218662196,218662260,218662514,218662679,3951,"60,53","35,45","77,74","42,53",298,149,0.604945587733,0.77287744043971,"0.462,0.371","0.478,0.411",-0.028]
[3969,"ENSG00000135597.18","REPS1","chr6","-",138926400,138930098,138926400,138926481,138929976,138930098,3969,"27,23",220194,"43,40","50,26",298,149,{"v":1.11022302463e-16,"d":"1.11E-16"},{"v":1.20825877336452E-15,"d":"1.21E-15"},"0.058,0.056","0.301,0.435",-0.311]
[3980,"ENSG00000214021.15","TTLL3","chr3","+",9817644,9818920,9817644,9817759,9818821,9818920,3980,449435,"7,11",559602,"4,4",298,149,0.00704665023799,0.0164225714043529,"0.97,0.952","0.986,0.987",-0.025]
[3984,"ENSG00000214021.15","TTLL3","chr3","+",9834680,9835404,9834680,9834907,9835093,9835404,3984,460415,"20,32",715732,"63,55",298,149,0.092468458283,0.160954818251223,"0.92,0.866","0.85,0.869",0.034]
[4009,"ENSG00000214706.10","IFRD2","chr3","-",50289446,50289762,50289446,50289628,50289711,50289762,4009,"67,96",449501,125118,179176,232,149,0,0,"0.087,0.11","0.31,0.301",-0.207]
[4010,"ENSG00000214706.10","IFRD2","chr3","-",50289928,50290294,50289928,50290086,50290169,50290294,4010,"25,39",436367,"79,66",340342,232,149,{"v":7.81886763113e-08,"d":"7.82E-08"},{"v":3.85660362886817e-07,"d":"3.86E-07"},"0.036,0.064","0.13,0.11",-0.07]
[4021,"ENSG00000164032.11","H2AFZ","chr4","-",99948087,99948940,99948087,99948523,99948810,99948940,4021,227220,113639888,181263,66716733,298,149,3.18636084515E-4,0.000936758501253826,"0.01,0.011","0.013,0.019",-0.006]
[4034,"ENSG00000179818.13","PCBP1-AS1","chr2","-",69996685,69996888,69996685,69996777,69996857,69996888,4034,"60,66","0,0",98155,"1,0",229,149,1,1,"1.0,1.0","0.985,1.0",0.008]
[4046,"ENSG00000096080.11","MRPS18A","chr6","-",43675201,43675617,43675201,43675271,43675493,43675617,4046,"61,50",602593,110128,484465,298,149,{"v":1.68393521349E-10,"d":"1.68E-10"},{"v":1.08711191673606e-09,"d":"1.09E-09"},"0.048,0.04","0.102,0.121",-0.067]
[4055,"ENSG00000168291.12","PDHB","chr3","-",58429707,58430238,58429707,58429799,58430127,58430238,4055,"12,14",13461276,"18,40",643712,298,149,{"v":8.25363374674e-05,"d":"8.25E-05"},2.65515200869703E-4,"0.004,0.005","0.014,0.027",-0.016]
[4071,"ENSG00000168894.9","RNF181","chr2","+",85597103,85597581,85597103,85597178,85597444,85597581,4071,"16,5",1120983,"44,41",908830,298,149,{"v":1.26201493811E-7,"d":"1.26E-07"},{"v":6.09182185283006e-07,"d":"6.09E-07"},"0.007,0.003","0.024,0.024",-0.019]
[4077,"ENSG00000132300.18","PTCD3","chr2","+",86130647,86131106,86130647,86130737,86131077,86131106,4077,163140,1040965,191172,593577,298,149,{"v":4.91795816293e-08,"d":"4.92E-08"},{"v":2.49579801958319E-7,"d":"2.50E-07"},"0.073,0.068","0.139,0.13",-0.064]
[4099,"ENSG00000198689.11","SLC9A6","chrX","+",135985434,135985827,135985434,135985477,135985602,135985827,4099,"25,34","9,5","2,9","1,4",274,149,0.367721030035,0.526173077342758,"0.602,0.787","0.521,0.55",0.159]
[4100,"ENSG00000077152.10","UBE2T","chr1","-",202333009,202333335,202333009,202333093,202333236,202333335,4100,"115,79",17171671,431411,837979,292,149,0,0,"0.033,0.024","0.208,0.176",-0.164]
[4110,"ENSG00000130414.11","NDUFA10","chr2","-",240011616,240014860,240011616,240011696,240014738,240014860,4110,337299,766639,126220,409399,298,149,0.568823121656,0.737651192199431,"0.18,0.19","0.133,0.216",0.011]
[4126,"ENSG00000204394.12","VARS","chr6","-",31782529,31782845,31782529,31782633,31782720,31782845,4126,"67,49",751592,"43,36",212208,236,149,{"v":4.65479095454e-05,"d":"4.65E-05"},0.000156423392912835,"0.053,0.05","0.114,0.099",-0.055]
[4140,"ENSG00000165699.14","TSC1","chr9","-",132910570,132911568,132910570,132910689,132911452,132911568,4140,"40,45","0,0",109187,"1,2",298,149,0.507012237062,0.678090010635472,"1.0,1.0","0.982,0.979",0.02]
[4154,"ENSG00000283189.2","AC104452.1","chr3","-",49419709,49420342,49419709,49419788,49420214,49420342,4154,"41,44","1,0","25,22","0,0",298,149,1,1,"0.953,1.0","1.0,1.0",-0.024]
[4167,"ENSG00000153094.22","BCL2L11","chr2","+",111123732,111124139,111123732,111123869,111124049,111124139,4167,141169,"41,55",205206,"27,41",298,149,0.00214628653015,0.00551089263287973,"0.632,0.606","0.792,0.715",-0.135]
[4181,"ENSG00000142798.19","HSPG2","chr1","-",21878185,21878491,21878185,21878253,21878432,21878491,4181,"14,13",121168,"24,40","101,91",298,149,{"v":9.14864658697e-07,"d":"9.15E-07"},{"v":3.94998435442881e-06,"d":"3.95E-06"},"0.055,0.037","0.106,0.18",-0.097]
[4195,"ENSG00000167851.14","CD300A","chr17","+",74481288,74481833,74481288,74481326,74481725,74481833,4195,"3,4","43,17","1,5","18,31",298,149,0.88695940206,1,"0.034,0.105","0.027,0.075",0.019]
[4196,"ENSG00000138074.14","SLC5A6","chr2","-",27202812,27203345,27202812,27202880,27203232,27203345,4196,196206,520561,"100,84",300307,298,149,0.141332533784,0.232371057798018,"0.159,0.155","0.143,0.12",0.025]
[4215,"ENSG00000110697.12","PITPNM1","chr11","-",67496177,67497436,67496177,67496348,67497230,67497436,4215,"50,59",101164,"38,22","77,92",298,149,0.447984854314,0.615071797951368,"0.198,0.152","0.198,0.107",0.022]
[4226,"ENSG00000063660.8","GPC1","chr2","+",240463346,240464746,240463346,240463512,240464615,240464746,4226,"0,0","1,2","1,2","1,3",298,149,0.0863565271838,0.151483076335353,"0.0,0.0","0.333,0.25",-0.291]
[4240,"ENSG00000178149.16","DALRD3","chr3","-",49015972,49016340,49015972,49016060,49016157,49016340,4240,81116,"39,23","88,46","11,6",246,149,0.00921461204818,0.0210208337349106,"0.557,0.753","0.829,0.823",-0.171]
[4248,"ENSG00000171777.15","RASGRP4","chr19","-",38411114,38411381,38411114,38411249,38411344,38411381,4248,"57,71",293360,"80,50","124,89",244,149,{"v":2.49543274933e-10,"d":"2.50E-10"},{"v":1.57457824409186E-9,"d":"1.57E-09"},"0.106,0.107","0.283,0.255",-0.163]
[4257,"ENSG00000082269.16","FAM135A","chr6","+",70524930,70526698,70524930,70525191,70525863,70526698,4257,129126,"19,16","85,97","0,2",298,149,{"v":4.01630124713e-08,"d":"4.02E-08"},{"v":2.06025399109533e-07,"d":"2.06E-07"},"0.772,0.797","1.0,0.96",-0.196]
[4276,"ENSG00000105193.8","RPS16","chr19","-",39433664,39435708,39433664,39433761,39435657,39435708,4276,977110574,678657,1220912690,614675,298,149,0.027514829175,0.055438583624363,"0.878,0.889","0.909,0.904",-0.023]
[4298,"ENSG00000162300.12","ZFPL1","chr11","+",65085114,65086608,65085114,65085226,65086414,65086608,4298,"22,25",225243,"17,15","80,74",298,149,0.0109279184026,0.024424386632283,"0.047,0.049","0.096,0.092",-0.046]
[4300,"ENSG00000131143.8","COX4I1","chr16","+",85804936,85805864,85804936,85805104,85805732,85805864,4300,174200,55054891,550593,46955084,298,149,0,0,"0.016,0.02","0.055,0.055",-0.037]
[4310,"ENSG00000128694.11","OSGEPL1","chr2","-",189761419,189761660,189761419,189761525,189761646,189761660,4310,157178,"3,0",155197,"4,1",270,149,0.410402164039,0.573089543368174,"0.967,1.0","0.955,0.991",0.011]
[4322,"ENSG00000114062.19","UBE3A","chr15","-",25333727,25340228,25333727,25339257,25340084,25340228,4322,"35,34",636579,"110,86",529635,298,149,{"v":1.63435931455e-10,"d":"1.63E-10"},{"v":1.05943100376226E-9,"d":"1.06E-09"},"0.027,0.029","0.094,0.063",-0.051]
[4339,"ENSG00000163449.10","TMEM169","chr2","+",216081918,216082232,216081918,216081979,216082146,216082232,4339,"2,5","0,0","16,18","2,0",298,149,0.867833234461,1,"1.0,1.0","0.8,1.0",0.1]
[4347,"ENSG00000204348.9","DXO","chr6","-",31970605,31971147,31970605,31970825,31970911,31971147,4347,"1,4",145120,"4,2","37,25",235,149,0.0342186103924,0.0670385244888265,"0.004,0.021","0.064,0.048",-0.043]
[4357,"ENSG00000140043.11","PTGR2","chr14","+",73876997,73880176,73876997,73877168,73880054,73880176,4357,"44,25","15,13","31,11","105,87",298,149,{"v":4.4408920985E-16,"d":"4.44E-16"},{"v":4.62105987004002e-15,"d":"4.62E-15"},"0.595,0.49","0.129,0.059",0.449]
[4368,"ENSG00000100650.15","SRSF5","chr14","+",69768797,69770540,69768797,69768896,69770466,69770540,4368,669624,"0,1",20592129,"25,24",298,149,0.00058783640147,1.65046374258884E-3,"1.0,0.997","0.976,0.978",0.021]
[4382,"ENSG00000187091.13","PLCD1","chr3","-",38008457,38009158,38008457,38008636,38009041,38009158,4382,"2,0","7,9","0,2","0,1",298,149,1,1,"0.125,0.0","NA,0.5",-0.438]
[4383,"ENSG00000187091.13","PLCD1","chr3","-",38009271,38009811,38009271,38009431,38009652,38009811,4383,"0,0","7,8","4,1","8,0",298,149,0.0435855145943,0.0826922298080581,"0.0,0.0","0.2,1.0",-0.6]
[4395,"ENSG00000174373.16","RALGAPA1","chr14","-",35688458,35690003,35688458,35688540,35689835,35690003,4395,"14,13","2,0","32,17","1,0",298,149,0.387718016022,0.546885251493576,"0.778,1.0","0.941,1.0",-0.081]
[4406,"ENSG00000115677.16","HDLBP","chr2","-",241235120,241235594,241235120,241235275,241235489,241235594,4406,"92,56","0,2",109125,"10,14",298,149,{"v":2.14640445099e-05,"d":"2.15E-05"},{"v":7.66342296459559e-05,"d":"7.66E-05"},"1.0,0.933","0.845,0.817",0.136]
[4414,"ENSG00000160410.14","SHKBP1","chr19","+",40577157,40577441,40577157,40577284,40577395,40577441,4414,"8,5",511519,"27,34",350369,260,149,{"v":5.89263082773e-11,"d":"5.89E-11"},{"v":4.02889528495372e-10,"d":"4.03E-10"},"0.009,0.005","0.042,0.05",-0.039]
[4426,"ENSG00000159433.11","STARD9","chr15","+",42663280,42663917,42663280,42663490,42663819,42663917,4426,"12,7","2,17","2,2","0,2",298,149,0.356048505735,0.512265057523521,"0.75,0.171","1.0,0.333",-0.206]
[4437,"ENSG00000130714.15","POMT1","chr9","+",131509902,131510415,131509902,131509996,131510259,131510415,4437,"56,74","33,31",123142,"28,21",298,149,{"v":9.62894744055e-05,"d":"9.63E-05"},0.000306639970506105,"0.459,0.544","0.687,0.772",-0.228]
[4447,"ENSG00000185122.10","HSF1","chr8","+",144309771,144311249,144309771,144309896,144311173,144311249,4447,90103,655569,140145,572616,298,149,0.00320405091898,0.00799328160386966,"0.064,0.083","0.109,0.105",-0.033]
[4459,"ENSG00000144635.8","DYNC1LI1","chr3","-",32530283,32533097,32530283,32530328,32532985,32533097,4459,"8,0","4,7","12,12","4,7",298,149,0.0460885522912,0.0869197856207249,"0.5,0.0","0.6,0.462",-0.281]
[4460,"ENSG00000144635.8","DYNC1LI1","chr3","-",32570345,32570858,32570345,32570419,32570624,32570858,4460,"18,11",731680,"22,20",613608,298,149,0.0529897177546,0.0983709744701005,"0.012,0.008","0.018,0.016",-0.007]
[4475,"ENSG00000197355.10","UAP1L1","chr9","+",137081997,137084538,137081997,137082064,137082636,137084538,4475,"74,85",245193,102118,270297,298,149,0.68145703489,0.844479924406646,"0.131,0.18","0.159,0.166",-0.007]
[4489,"ENSG00000178035.11","IMPDH2","chr3","-",49024494,49024802,49024494,49024578,49024658,49024802,4489,100152,28642805,168237,15931772,229,149,{"v":1.72084568817e-14,"d":"1.72E-14"},{"v":1.60420683504256e-13,"d":"1.60E-13"},"0.022,0.034","0.064,0.08",-0.044]
[4496,"ENSG00000164128.6","NPY1R","chr4","-",163325855,163326705,163325855,163325931,163326664,163326705,4496,47424188,"28,46",56305882,"2,13",298,149,3.77835472221E-3,0.00932308536499555,"0.988,0.979","0.999,0.996",-0.014]
[4513,"ENSG00000075624.14","ACTB","chr7","-",5529160,5529663,5529160,5529400,5529534,5529663,4513,499470,4300041603,395461,3426934635,283,149,1,1,"0.006,0.006","0.006,0.007",-1E-3]
[4530,"ENSG00000132382.14","MYBBP1A","chr17","-",4538901,4539967,4538901,4538975,4539438,4539967,4530,355416,"8,2",185217,"3,5",298,149,0.54309237097,0.715031437362,"0.957,0.99","0.969,0.956",0.011]
[4540,"ENSG00000172932.14","ANKRD13D","chr11","+",67291475,67291746,67291475,67291521,67291602,67291746,4540,"14,10",159173,"43,31",157196,230,149,{"v":1.5708222051e-05,"d":"1.57E-05"},{"v":5.70791476027699e-05,"d":"5.71E-05"},"0.054,0.036","0.151,0.093",-0.077]
[4555,"ENSG00000122545.19","2024-09-07","chr7","+",35898247,35903215,35898247,35898383,35903075,35903215,4555,"41,13",17411716,"11,11",17621801,298,149,0.865322289494,1,"0.012,0.004","0.003,0.003",0.005]
[4556,"ENSG00000010270.13","STARD3NL","chr7","+",38215027,38217305,38215027,38215105,38217187,38217305,4556,"3,3","68,54","21,27",351388,298,149,0.239140877616,0.365504185619863,"0.022,0.027","0.029,0.034",-0.007]
[4565,"ENSG00000176978.13","DPP7","chr9","-",137114462,137114718,137114462,137114576,137114646,137114718,4565,159216,163210,223294,126197,219,149,8.88012224539E-4,0.00243140104179893,"0.399,0.412","0.546,0.504",-0.12]
[4575,"ENSG00000136286.15","MYO1G","chr7","-",44972114,44975227,44972114,44972274,44975173,44975227,4575,"35,34","7,8",104104,"0,8",298,149,1.80124652845E-4,5.48230582263967E-4,"0.714,0.68","1.0,0.867",-0.236]
[4587,"ENSG00000126522.16","ASL","chr7","+",66089090,66089335,66089090,66089175,66089275,66089335,4587,"15,12",331339,"2,2","56,71",249,149,0.266470157385,0.40126972287903,"0.026,0.021","0.021,0.017",0.004]
[4602,"ENSG00000167965.17","MLST8","chr16","+",2206357,2206659,2206357,2206409,2206554,2206659,4602,301367,"22,23",272249,"22,14",294,149,0.934329429433,1,"0.874,0.89","0.862,0.9",1E-3]
[4613,"ENSG00000106077.18","ABHD11","chr7","-",73737220,73737735,73737220,73737360,73737561,73737735,4613,"83,93","0,0","112,86","0,1",298,149,1,1,"1.0,1.0","1.0,0.977",0.012]
[4625,"ENSG00000183506.17","PI4KAP2","chr22","-",21475210,21476764,21475210,21475300,21476001,21476764,4625,"26,53","116,89","29,41",79109,298,149,0.959550315634,1,"0.101,0.229","0.155,0.158",0.009]
[4635,"ENSG00000135218.18","CD36","chr7","+",80672769,80674147,80672769,80672843,80673982,80674147,4635,"36,14","0,0",210210,"7,9",298,149,0.00224506171011,0.00573348644481805,"1.0,1.0","0.938,0.921",0.071]
[4645,"ENSG00000234545.7","FAM133B","chr7","-",92577654,92578182,92577654,92577717,92578149,92578182,4645,"74,92",388345,"76,72",350394,298,149,0.419323884724,0.582462480390919,"0.087,0.118","0.098,0.084",0.011]
[4661,"ENSG00000090581.9","GNPTG","chr16","+",1352101,1352306,1352101,1352159,1352238,1352306,4661,"48,34",113124,167211,"74,91",228,149,0,0,"0.217,0.152","0.596,0.602",-0.414]
[4682,"ENSG00000172354.9","GNB2","chr7","+",100676692,100677415,100676692,100676799,100677351,100677415,4682,"49,22",12151390,"57,48",910823,298,149,{"v":1.62029324278e-05,"d":"1.62E-05"},{"v":5.87840913164052e-05,"d":"5.88E-05"},"0.02,0.008","0.03,0.028",-0.015]
[4692,"ENSG00000049089.14","COL9A2","chr1","-",40312058,40312479,40312058,40312112,40312455,40312479,4692,"3,9","36,44","12,6","57,40",298,149,0.547321235106,0.719003117546503,"0.04,0.093","0.095,0.07",-0.016]
[4702,"ENSG00000146830.10","GIGYF1","chr7","-",100685973,100686433,100685973,100686079,100686179,100686433,4702,"55,52","108,99","40,54",192197,249,149,{"v":7.90308538227e-05,"d":"7.90E-05"},2.5527665172819E-4,"0.234,0.239","0.111,0.141",0.11]
[4715,"ENSG00000110321.16","EIF4G2","chr11","-",10799551,10800348,10799551,10799756,10800089,10800348,4715,381321,70306431,13391268,44724611,298,149,0,0,"0.026,0.024","0.13,0.121",-0.101]
[4725,"ENSG00000148337.20","CIZ1","chr9","-",128178708,128179415,128178708,128178904,128179243,128179415,4725,16061628,"2,1",14461340,"0,0",298,149,1,1,"0.998,0.999","1.0,1.0",-2E-3]
[4742,"ENSG00000115257.15","PCSK4","chr19","-",1486852,1487313,1486852,1487065,1487140,1487313,4742,"2,4","9,7","1,2","3,10",224,149,0.558471370637,0.728407546364091,"0.129,0.275","0.181,0.117",0.053]
[4756,"ENSG00000165516.10","KLHDC2","chr14","+",49779594,49779806,49779594,49779675,49779747,49779806,4756,"67,53",195188,"20,16","9,16",221,149,{"v":2.59803009787E-5,"d":"2.60E-05"},{"v":9.09118939114539e-05,"d":"9.09E-05"},"0.188,0.16","0.6,0.403",-0.328]
[4760,"ENSG00000157456.7","CCNB2","chr15","+",59107321,59107670,59107321,59107450,59107556,59107670,4760,"6,4",1150971,"18,9",16701739,255,149,1,1,"0.003,0.002","0.006,0.003",-2E-3]
[4783,"ENSG00000143303.11","RRNAD1","chr1","+",156731990,156732473,156731990,156732115,156732280,156732473,4783,145117,"91,79",228228,"42,44",298,149,{"v":4.91551244153e-12,"d":"4.92E-12"},{"v":3.68469297552288e-11,"d":"3.68E-11"},"0.443,0.425","0.731,0.722",-0.292]
[4804,"ENSG00000055118.14","KCNH2","chr7","-",150950920,150951835,150950920,150951120,150951447,150951835,4804,182192,15021679,249274,11751094,298,149,{"v":5.50411582978e-08,"d":"5.50E-08"},{"v":2.76663449282903e-07,"d":"2.77E-07"},"0.057,0.054","0.096,0.111",-0.048]
[4817,"ENSG00000139350.11","NEDD1","chr12","+",96907603,96907856,96907603,96907624,96907701,96907856,4817,140130,"2,0",113115,"0,1",226,149,1,1,"0.979,1.0","1.0,0.987",-0.004]
[4841,"ENSG00000134253.9","TRIM45","chr1","-",117111059,117112453,117111059,117111212,117112094,117112453,4841,"43,42","1,9","36,12","0,0",298,149,0.000165191920436,0.000505700427399238,"0.956,0.7","1.0,1.0",-0.172]
[4850,"ENSG00000137802.13","MAPKBP1","chr15","+",41812515,41813781,41812515,41813101,41813620,41813781,4850,"8,4","31,26","7,22","16,39",298,149,0.013506005067,0.0295055221192058,"0.114,0.071","0.179,0.22",-0.107]
[4866,"ENSG00000184661.13","CDCA2","chr8","+",25460239,25460554,25460239,25460300,25460383,25460554,4866,"50,55",218219,283297,186163,232,149,0,0,"0.128,0.139","0.494,0.539",-0.383]
[4873,"ENSG00000120885.21","CLU","chr8","-",27604923,27605335,27604923,27605069,27605171,27605335,4873,520459,"8,18",669670,"16,11",251,149,0.377297525275,0.535850570915856,"0.975,0.938","0.961,0.973",-0.011]
[4877,"ENSG00000173020.10","GRK2","chr11","+",67281821,67282542,67281821,67281952,67282270,67282542,4877,253294,16461470,302297,11241154,298,149,0.000743150743726,0.00206575880432329,"0.071,0.091","0.118,0.114",-0.035]
[4887,"ENSG00000147475.15","ERLIN2","chr8","+",37744570,37746550,37744570,37744696,37745568,37746550,4887,"16,30","28,14","30,27","4,0",298,149,{"v":6.52634499887e-06,"d":"6.53E-06"},{"v":2.51768349753155E-5,"d":"2.52E-05"},"0.222,0.517","0.789,1.0",-0.525]
[4899,"ENSG00000143322.19","ABL2","chr1","-",179107717,179109441,179107717,179108898,179109207,179109441,4899,173142,"33,28",209179,"58,54",298,149,0.0429620166641,0.0817708660534113,"0.724,0.717","0.643,0.624",0.087]
[4912,"ENSG00000260669.2","AL096870.2","chr14","-",24215551,24215797,24215551,24215662,24215736,24215797,4912,"94,82",136140,124166,"19,48",223,149,0,0,"0.316,0.281","0.813,0.698",-0.457]
[4930,"ENSG00000196628.16","TCF4","chr18","-",55227848,55228361,55227848,55228030,55228220,55228361,4930,"7,7","78,89","6,8",125116,298,149,0.402540037375,0.564491360965777,"0.043,0.038","0.023,0.033",0.012]
[4940,"ENSG00000104231.10","ZFAND1","chr8","-",81713917,81714895,81713917,81714039,81714803,81714895,4940,"61,40",332247,150106,145170,298,149,{"v":4.4408920985E-16,"d":"4.44E-16"},{"v":4.62105987004002e-15,"d":"4.62E-15"},"0.084,0.075","0.341,0.238",-0.21]
[4950,"ENSG00000085719.12","CPNE3","chr8","+",86551045,86551234,86551045,86551100,86551182,86551234,4950,"2,0",116116,"1,0","83,69",231,149,1,1,"0.011,0.0","0.008,0.0",1E-3]
[4952,"ENSG00000104327.7","CALB1","chr8","-",90060628,90063153,90060628,90060700,90063099,90063153,4952,"0,0","0,2","0,1","0,0",298,149,1,1,"NA,0.0","NA,1.0",-1]
[4962,"ENSG00000141294.9","LRRC46","chr17","+",47834424,47835399,47834424,47834533,47835352,47835399,4962,"10,7","24,21","9,3","7,5",298,149,0.104246052928,0.17837992107586,"0.172,0.143","0.391,0.231",-0.154]
[4979,"ENSG00000160948.13","VPS28","chr8","-",144424717,144425772,144424717,144424819,144425682,144425772,4979,184180,"1,0",191242,"5,3",298,149,0.0389333536645,0.0752433516771085,"0.989,1.0","0.95,0.976",0.031]
[4989,"ENSG00000214087.8","ARL16","chr17","-",81682033,81682675,81682033,81682149,81682442,81682675,4989,218298,"3,2",83107,"4,1",298,149,0.233164658795,0.358068571922129,"0.973,0.987","0.912,0.982",0.033]
[5008,"ENSG00000129292.20","PHF20L1","chr8","+",132814636,132817545,132814636,132814889,132817338,132817545,5008,"49,72","0,0","96,69","4,4",298,149,0.00153888566456,0.00404767875739312,"1.0,1.0","0.923,0.896",0.091]
[5014,"ENSG00000177595.17","PIDD1","chr11","-",799814,800244,799814,800014,800130,800244,5014,"20,32","66,55","8,21","22,33",265,149,0.616925747527,0.78438174491308,"0.146,0.246","0.17,0.264",-0.021]
[5030,"ENSG00000104518.10","GSDMD","chr8","+",143559776,143561423,143559776,143559969,143561369,143561423,5030,"77,89","0,0","117,83","3,1",298,149,0.53175920439,0.704803749952667,"1.0,1.0","0.951,0.976",0.036]
[5039,"ENSG00000104529.17","EEF1D","chr8","-",143581053,143581328,143581053,143581154,143581285,143581328,5039,788810,132119,1005986,115151,280,149,0.233505551822,0.358338888549608,"0.761,0.784","0.823,0.777",-0.028]
[5040,"ENSG00000241404.6","EGFL8","chr6","+",32167349,32167656,32167349,32167429,32167502,32167656,5040,"91,92","28,33","44,56","27,33",222,149,0.014127433412,0.0306514273159305,"0.686,0.652","0.522,0.532",0.142]
[5053,"ENSG00000179698.13","WDR97","chr8","+",144113976,144114475,144113976,144114162,144114277,144114475,5053,"8,4","0,0","3,4","0,4",264,149,0.0057543260412,0.0136316909962526,"1.0,1.0","1.0,0.361",0.32]
[5065,"ENSG00000071894.16","CPSF1","chr8","-",144394233,144394555,144394233,144394300,144394378,144394555,5065,182167,596594,219227,284260,227,149,{"v":9.7699626167e-15,"d":"9.77E-15"},{"v":9.29027507339509e-14,"d":"9.29E-14"},"0.167,0.156","0.336,0.364",-0.188]
[5075,"ENSG00000011295.15","TTC19","chr17","+",16026539,16028786,16026539,16026702,16027373,16028786,5075,"93,58",828665,208208,443414,298,149,0,0,"0.053,0.042","0.19,0.201",-0.148]
[5088,"ENSG00000137145.20","DENND4C","chr9","+",19336269,19336832,19336269,19336414,19336685,19336832,5088,"8,13","60,98","11,31",104101,298,149,0.137428328255,0.226658817368778,"0.062,0.062","0.05,0.133",-0.029]
[5097,"ENSG00000165280.15","VCP","chr9","-",35060312,35060923,35060312,35060525,35060800,35060923,5097,"77,59",917753,"69,55",858802,298,149,0.604042007911,0.772346895051925,"0.04,0.038","0.039,0.033",0.003]
[5114,"ENSG00000161513.11","FDXR","chr17","-",74863895,74864347,74863895,74864067,74864147,74864347,5114,"16,31",180204,"52,31","62,57",229,149,{"v":4.34208224931E-13,"d":"4.34E-13"},{"v":3.64013785741624e-12,"d":"3.64E-12"},"0.055,0.09","0.353,0.261",-0.234]
[5125,"ENSG00000140465.13","CYP1A1","chr15","-",74720719,74721053,74720719,74720774,74720966,74721053,5125,"0,0","6,6","8,0","0,2",298,149,0.00835644930262,0.0192669348595393,"0.0,0.0","1.0,0.0",-0.5]
[5127,"ENSG00000196873.15","CBWD3","chr9","+",68297751,68299965,68297751,68297817,68299480,68299965,5127,"5,0","0,1","2,5","4,4",298,149,0.664562537097,0.829828746980332,"1.0,0.0","0.2,0.385",0.208]
[5140,"ENSG00000196730.12","DAPK1","chr9","+",87639649,87639815,87639649,87639698,87639788,87639815,5140,"26,22",214229,"43,39",237243,239,149,0.0309735784836,0.0612884194765145,"0.07,0.057","0.102,0.091",-0.033]
[5154,"ENSG00000141503.15","MINK1","chr17","+",4889646,4890735,4889646,4889763,4890516,4890735,5154,"16,23","66,91","26,34","86,73",298,149,0.0900687565531,0.157059523305236,"0.108,0.112","0.131,0.189",-0.05]
[5168,"ENSG00000123349.13","PFDN5","chr12","+",53295838,53296467,53295838,53295941,53296429,53296467,5168,202192,"11,19",158193,"1,13",298,149,0.0419476457515,0.0801294601815086,"0.902,0.835","0.988,0.881",-0.066]
[5195,"ENSG00000090097.21","PCBP4","chr3","-",51960525,51960898,51960525,51960637,51960865,51960898,5195,"1,3","0,0","2,4","3,3",298,149,{"v":1.55431734594e-07,"d":"1.55E-07"},{"v":7.34585239689771e-07,"d":"7.35E-07"},"1.0,1.0","0.25,0.4",0.675]
[5208,"ENSG00000186073.12","C15orf41","chr15","+",36808323,36810248,36808323,36808489,36808903,36810248,5208,191151,"27,20",229212,"32,24",298,149,0.749106828542,0.910246325590727,"0.78,0.791","0.782,0.815",-0.013]
[5221,"ENSG00000149273.14","RPS3","chr11","+",75401639,75402446,75401639,75401725,75402379,75402446,5221,66526012,328210,78478378,282311,298,149,0.248945364745,0.378725795355891,"0.91,0.935","0.933,0.931",-0.009]
[5235,"ENSG00000213213.13","CCDC183","chr9","+",136806077,136806672,136806077,136806238,136806503,136806672,5235,"5,6","0,2","15,12","1,0",298,149,0.56413997169,0.733784036641735,"1.0,0.6","0.882,1.0",-0.141]
[5236,"ENSG00000213213.13","CCDC183","chr9","+",136806077,136806867,136806077,136806672,136806756,136806867,5236,"9,1","4,0","28,5","2,1",233,149,0.255935198338,0.387619698727676,"0.59,1.0","0.9,0.762",-0.036]
[5246,"ENSG00000107331.16","ABCA2","chr9","-",137011406,137011749,137011406,137011554,137011633,137011749,5246,"5,14","54,91","3,4","53,68",228,149,0.0430011476572,0.0817797377288232,"0.057,0.091","0.036,0.037",0.037]
[5260,"ENSG00000168090.9","COPS6","chr7","+",100090591,100091152,100090591,100090654,100091037,100091152,5260,"39,41","1,0","51,52","8,9",298,149,{"v":5.58465006506e-06,"d":"5.58E-06"},{"v":2.17741697277811e-05,"d":"2.18E-05"},"0.951,1.0","0.761,0.743",0.224]
[5269,"ENSG00000164117.13","FBXO8","chr4","-",174262763,174263100,174262763,174262795,174262918,174263100,5269,175131,"0,0",265188,"6,0",272,149,0.458834523609,0.626713913368818,"1.0,1.0","0.96,1.0",0.02]
[5285,"ENSG00000167522.15","ANKRD11","chr16","-",89290624,89291183,89290624,89290828,89291012,89291183,5285,"10,10",410387,"35,27",780875,298,149,0.0975288182693,0.168281542795574,"0.012,0.013","0.022,0.015",-0.006]
[5295,"ENSG00000206503.12","HLA-A","chr6","+",29944499,29945091,29944499,29944616,29945058,29945091,5295,"18,8",749627,"26,21",562523,298,149,0.00201145079759,0.00519342786865973,"0.012,0.006","0.023,0.02",-0.012]
[5317,"ENSG00000072134.15","EPN2","chr17","+",19281954,19283714,19281954,19282077,19282949,19283714,5317,"0,0","15,18","1,3","24,37",298,149,0.88095916662,1,"0.0,0.0","0.02,0.039",-0.029]
[5328,"ENSG00000228065.10","LINC01515","chr10","+",65585484,65585802,65585484,65585567,65585664,65585802,5328,111156,"25,25",122131,"22,18",246,149,0.475388523827,0.645782578173236,"0.729,0.791","0.771,0.815",-0.033]
[5329,"ENSG00000141499.16","WRAP53","chr17","+",7688476,7689079,7688476,7688561,7688647,7689079,5329,"27,55",136190,"42,71",106121,235,149,0.000560681484711,0.00157982995543568,"0.112,0.155","0.201,0.271",-0.103]
[5339,"ENSG00000165644.10","COMTD1","chr10","-",75234937,75235178,75234937,75234992,75235059,75235178,5339,"16,18","30,38","8,6","5,4",216,149,0.0206567511914,0.042876764830793,"0.269,0.246","0.525,0.509",-0.26]
[5357,"ENSG00000079616.12","KIF22","chr16","+",29799263,29799781,29799263,29799494,29799627,29799781,5357,"39,47",877798,"60,38",772904,282,149,0.47749567781,0.648273817227024,"0.023,0.03","0.039,0.022",-0.004]
[5367,"ENSG00000115073.7","ACTR1B","chr2","-",97658426,97659003,97658426,97658643,97658878,97659003,5367,118139,142190,191175,"30,22",298,149,0,0,"0.294,0.268","0.761,0.799",-0.499]
[5381,"ENSG00000149179.13","C11orf49","chr11","+",47161126,47162247,47161126,47161190,47161445,47162247,5381,"8,15","3,0","26,29","1,3",298,149,0.704157748177,0.866950834224147,"0.571,1.0","0.929,0.829",-0.094]
[5394,"ENSG00000167792.12","NDUFV1","chr11","+",67606957,67607324,67606957,67607076,67607298,67607324,5394,290346,"9,1",609610,"13,22",298,149,0.0474909392107,0.0890689749228345,"0.942,0.994","0.959,0.933",0.022]
[5402,"ENSG00000107679.14","PLEKHA1","chr10","+",122417899,122424263,122417899,122417968,122424198,122424263,5402,"0,4","36,25","4,1","34,23",298,149,0.616269830439,0.783757798293501,"0.0,0.074","0.056,0.021",-2E-3]
[5417,"ENSG00000147894.15","C9orf72","chr9","-",27558490,27560299,27558490,27558607,27560226,27560299,5417,"31,24","14,16","17,5","25,29",298,149,{"v":6.93008615664e-05,"d":"6.93E-05"},2.25846557783357E-4,"0.525,0.429","0.254,0.079",0.31]
[5419,"ENSG00000090857.13","PDPR","chr16","+",70128783,70129122,70128783,70128865,70128958,70129122,5419,"16,11",283290,"42,50",194192,242,149,{"v":1.8979262606e-12,"d":"1.90E-12"},{"v":1.49595682833006e-11,"d":"1.50E-11"},"0.034,0.023","0.118,0.138",-0.1]
[5432,"ENSG00000130600.18","H19","chr11","-",1995175,1995998,1995175,1995788,1995875,1995998,5432,"9,12","4,4","3,0","5,2",236,149,4.20739989793E-3,0.0102380064182963,"0.587,0.654","0.275,0.0",0.483]
[5447,"ENSG00000142327.12","RNPEPL1","chr2","+",240573774,240574628,240573774,240573891,240574514,240574628,5447,"38,43","1,0","41,69","9,16",298,149,{"v":1.37428264324e-07,"d":"1.37E-07"},{"v":6.5537398413807e-07,"d":"6.55E-07"},"0.95,1.0","0.695,0.683",0.286]
[5453,"ENSG00000143321.18","HDGF","chr1","-",156745007,156745373,156745007,156745146,156745296,156745373,5453,113102,34923301,128215,34083344,298,149,0.000593812769645,1.66527280849026E-3,"0.016,0.015","0.018,0.031",-0.009]
[5464,"ENSG00000166340.16","TPP1","chr11","-",6616314,6616859,6616314,6616503,6616660,6616859,5464,"29,52",390387,126113,336337,298,149,{"v":1.08912878716e-13,"d":"1.09E-13"},{"v":9.53490054441734e-13,"d":"9.53E-13"},"0.036,0.063","0.158,0.144",-0.101]
[5473,"ENSG00000166340.16","TPP1","chr11","-",6619195,6619413,6619195,6619259,6619383,6619413,5473,"27,17","6,5","25,29","12,5",273,149,0.703179808336,0.865971500273636,"0.711,0.65","0.532,0.76",0.034]
[5487,"ENSG00000174744.13","BRMS1","chr11","-",66338242,66338785,66338242,66338282,66338720,66338785,5487,"30,21",527577,"25,45",580617,298,149,0.272041790798,0.407976705858568,"0.028,0.018","0.021,0.035",-0.005]
[5503,"ENSG00000137504.13","CREBZF","chr11","-",85663523,85665102,85663523,85663601,85663814,85665102,5503,12041193,313345,14351384,217215,298,149,{"v":1.36325319167E-6,"d":"1.36E-06"},{"v":5.77886804126705e-06,"d":"5.78E-06"},"0.658,0.634","0.768,0.763",-0.12]
[5504,"ENSG00000007372.22","PAX6","chr11","-",31790709,31793553,31790709,31790860,31793437,31793553,5504,"14,8",147147,"20,28",98111,298,149,{"v":5.09012967205e-05,"d":"5.09E-05"},1.7032909234046E-4,"0.045,0.026","0.093,0.112",-0.067]
[5520,"ENSG00000173801.16","JUP","chr17","-",41754603,41755895,41754603,41755432,41755729,41755895,5520,283296,267289,431495,186156,298,149,{"v":1.00514041534E-11,"d":"1.01E-11"},{"v":7.32625387217864e-11,"d":"7.33E-11"},"0.346,0.339","0.537,0.613",-0.232]
[5535,"ENSG00000138459.8","SLC35A5","chr3","+",112580545,112581326,112580545,112580706,112581178,112581326,5535,386388,"4,0",506552,"0,0",298,149,1,1,"0.98,1.0","1.0,1.0",-0.01]
[5542,"ENSG00000149136.8","SSRP1","chr11","-",57326702,57327514,57326702,57326889,57327425,57327514,5542,"31,25",16931891,"25,25",11881236,298,149,1,1,"0.009,0.007","0.01,0.01",-2E-3]
[5554,"ENSG00000008128.22","CDK11A","chr1","-",1703475,1703940,1703475,1703624,1703823,1703940,5554,177157,634611,160178,9501038,298,149,0.00055240920557,1.56022719073193E-3,"0.122,0.114","0.078,0.079",0.039]
[5563,"ENSG00000149532.15","CPSF7","chr11","-",61415665,61416519,61415665,61415784,61416104,61416519,5563,106147,630556,"63,71",590796,298,149,{"v":1.59633633645E-7,"d":"1.60E-07"},{"v":7.52943928077062e-07,"d":"7.53E-07"},"0.078,0.117","0.051,0.043",0.051]
[5573,"ENSG00000111364.15","DDX55","chr12","+",123607431,123607662,123607431,123607523,123607603,123607662,5573,129114,"10,9",91129,"6,6",229,149,0.309804849669,0.455962782778971,"0.894,0.892","0.908,0.933",-0.028]
[5584,"ENSG00000175634.14","RPS6KB2","chr11","+",67429526,67432657,67429526,67429595,67432599,67432657,5584,"100,85","0,3",120114,"7,5",298,149,0.0171871246222,0.0363588525779487,"1.0,0.934","0.896,0.919",0.06]
[5585,"ENSG00000175634.14","RPS6KB2","chr11","+",67433125,67433447,67433125,67433216,67433339,67433447,5585,"78,80",533512,"64,58",156220,272,149,{"v":6.09751161029e-06,"d":"6.10E-06"},{"v":2.36765078484664E-5,"d":"2.37E-05"},"0.074,0.079","0.183,0.126",-0.078]
[5595,"ENSG00000173113.6","TRMT112","chr11","-",64316690,64317147,64316690,64316968,64317057,64317147,5595,157166,22742243,741822,12911492,238,149,0,0,"0.041,0.044","0.264,0.256",-0.218]
[5613,"ENSG00000162298.18","SYVN1","chr11","-",65130001,65130379,65130001,65130172,65130250,65130379,5613,"31,29","57,78","46,54","50,34",227,149,0.000209435295682,0.000631366250324707,"0.263,0.196","0.377,0.51",-0.214]
[5618,"ENSG00000162298.18","SYVN1","chr11","-",65132921,65133320,65132921,65133074,65133159,65133320,5618,"7,6",234210,"62,55",265259,234,149,{"v":3.77475828373e-15,"d":"3.77E-15"},{"v":3.68543787166643e-14,"d":"3.69E-14"},"0.019,0.018","0.13,0.119",-0.106]
[5628,"ENSG00000173039.18","RELA","chr11","-",65661686,65662088,65661686,65661835,65661936,65662088,5628,"9,16",503521,"86,75",517536,250,149,0,0,"0.011,0.018","0.09,0.077",-0.069]
[5638,"ENSG00000175467.14","SART1","chr11","+",65966075,65966556,65966075,65966218,65966349,65966556,5638,"15,28",808874,"16,13",514567,280,149,0.941756633424,1,"0.01,0.017","0.016,0.012",0]
[5648,"ENSG00000167799.9","NUDT8","chr11","-",67627938,67628400,67627938,67628251,67628322,67628400,5648,"43,52",152119,"42,45","36,42",220,149,{"v":1.63457781865E-7,"d":"1.63E-07"},{"v":7.70215665292378e-07,"d":"7.70E-07"},"0.161,0.228","0.441,0.421",-0.236]
[5655,"ENSG00000102901.12","CENPT","chr16","-",67829764,67831358,67829764,67830088,67831215,67831358,5655,345377,"4,8",538487,"17,4",298,149,0.504846991708,0.676121641449184,"0.977,0.959","0.941,0.984",0.006]
[5661,"ENSG00000102901.12","CENPT","chr16","-",67832227,67832545,67832227,67832350,67832454,67832545,5661,"104,71","1,1",99111,"1,2",253,149,0.644091800467,0.809593534626732,"0.984,0.977","0.983,0.97",0.004]
[5672,"ENSG00000089818.17","NECAP1","chr12","+",8090194,8092784,8090194,8090343,8092675,8092784,5672,"80,68","0,2",311350,"2,1",298,149,0.452851582679,0.620676129350622,"1.0,0.944","0.987,0.994",-0.018]
[5682,"ENSG00000186635.14","ARAP1","chr11","-",72696548,72697195,72696548,72696654,72696982,72697195,5682,"61,57",379382,"50,39",433439,298,149,0.0188055577826,0.0394658875181057,"0.074,0.069","0.055,0.043",0.023]
[5690,"ENSG00000165801.9","ARHGEF40","chr14","+",21088829,21089545,21088829,21088876,21089013,21089545,5690,"11,7","25,17","8,16","9,17",286,149,0.0557098700993,0.102657605289778,"0.186,0.177","0.317,0.329",-0.142]
[5704,"ENSG00000103024.7","NME3","chr16","-",1770880,1771410,1770880,1770993,1771069,1771410,5704,"13,21","1,6","16,0","0,10",225,149,0.340270909716,0.492702309002874,"0.896,0.699","1.0,0.0",0.297]
[5718,"ENSG00000159348.12","CYB5R1","chr1","-",202965886,202966600,202965886,202966109,202966527,202966600,5718,"28,26","1,2","64,83","2,0",298,149,0.184694401446,0.294085548611164,"0.933,0.867","0.941,1.0",-0.07]
[5729,"ENSG00000150316.11","CWC15","chr11","-",94970976,94971487,94970976,94971065,94971374,94971487,5729,"47,39",14221258,"39,30",14061396,298,149,0.173687632851,0.278616571290735,"0.016,0.015","0.014,0.011",0.003]
[5735,"ENSG00000122008.15","POLK","chr5","+",75597746,75598040,75597746,75597789,75597933,75598040,5735,"1,0","92,77","46,38",162177,293,149,{"v":3.96571664396e-13,"d":"3.97E-13"},{"v":3.35109065842123e-12,"d":"3.35E-12"},"0.005,0.0","0.126,0.098",-0.11]
[5741,"ENSG00000108349.16","CASC3","chr17","+",40163480,40164166,40163480,40163602,40163885,40164166,5741,10811020,"18,11",16131494,"15,21",298,149,0.575151847704,0.742207102897873,"0.968,0.979","0.982,0.973",-0.004]
[5756,"ENSG00000149582.15","TMEM25","chr11","+",118531191,118531871,118531191,118531234,118531777,118531871,5756,"1,2","0,0","3,16","0,1",298,149,1,1,"1.0,1.0","1.0,0.889",0.055]
[5765,"ENSG00000172375.13","C2CD2L","chr11","+",119114079,119117121,119114079,119114365,119116024,119117121,5765,"45,47","2,0","49,48","20,28",298,149,{"v":1.60368385238E-11,"d":"1.60E-11"},{"v":1.15120724350122e-10,"d":"1.15E-10"},"0.918,1.0","0.551,0.462",0.453]
[5779,"ENSG00000109927.10","TECTA","chr11","+",121168053,121168925,121168053,121168217,121168676,121168925,5779,"0,0","6,2","14,8","15,14",298,149,{"v":1.66209276954e-05,"d":"1.66E-05"},{"v":6.01573622537551e-05,"d":"6.02E-05"},"0.0,0.0","0.318,0.222",-0.27]
[5792,"ENSG00000154134.14","ROBO3","chr11","+",124877518,124878131,124877518,124877752,124877936,124878131,5792,"52,33","2,4","56,58","0,5",298,149,0.460341653753,0.628581625052657,"0.929,0.805","1.0,0.853",-0.059]
[5804,"ENSG00000002016.17","RAD52","chr12","-",916343,916820,916343,916483,916638,916820,5804,106121,"53,95",127157,"17,11",298,149,{"v":3.64042129775E-13,"d":"3.64E-13"},{"v":3.09012505506686E-12,"d":"3.09E-12"},"0.5,0.389","0.789,0.877",-0.388]
[5814,"ENSG00000148362.10","PAXX","chr9","+",136992639,136993243,136992639,136992700,136993052,136993243,5814,392371,"4,4",567534,"4,18",298,149,0.0676856220485,0.122070800691802,"0.98,0.979","0.986,0.937",0.018]
[5821,"ENSG00000010292.12","NCAPD2","chr12","+",6514264,6514587,6514264,6514392,6514463,6514587,5821,"47,63",11961241,"64,67",451434,220,149,{"v":1.79212200635E-12,"d":"1.79E-12"},{"v":1.41491163396518e-11,"d":"1.41E-11"},"0.026,0.033","0.088,0.095",-0.062]
[5828,"ENSG00000111642.15","CHD4","chr12","-",6578028,6578546,6578028,6578135,6578408,6578546,5828,355341,"10,3",198206,"9,10",298,149,0.0138514560573,0.0300801642983471,"0.947,0.983","0.917,0.912",0.05]
[5839,"ENSG00000111665.11","CDCA3","chr12","-",6849322,6849858,6849322,6849429,6849564,6849858,5839,"57,44",366319,"90,77",147157,284,149,{"v":2.55351295664e-14,"d":"2.55E-14"},{"v":2.34360134995295e-13,"d":"2.34E-13"},"0.076,0.067","0.243,0.205",-0.152]
[5849,"ENSG00000215021.8","PHB2","chr12","-",6970195,6970645,6970195,6970280,6970416,6970645,5849,"44,44",33223113,118121,18772137,285,149,0,0,"0.007,0.007","0.032,0.029",-0.024]
[5872,"ENSG00000081760.16","AACS","chr12","+",125124704,125125024,125124704,125124769,125124901,125125024,5872,"36,10","90,70","1,10","14,18",281,149,0.933376849256,1,"0.175,0.07","0.036,0.228",-0.01]
[5893,"ENSG00000172432.18","GTPBP2","chr6","-",43620489,43622167,43620489,43621790,43622002,43622167,5893,"104,67",470358,197196,561475,298,149,{"v":1.3938195072e-05,"d":"1.39E-05"},{"v":5.14682767444669e-05,"d":"5.15E-05"},"0.1,0.086","0.149,0.171",-0.067]
[5904,"ENSG00000129317.14","PUS7L","chr12","-",43754335,43755261,43754335,43754442,43755216,43755261,5904,260247,"0,0",224243,"3,0",298,149,1,1,"1.0,1.0","0.974,1.0",0.013]
[5916,"ENSG00000174243.9","DDX23","chr12","-",48837280,48837657,48837280,48837393,48837523,48837657,5916,110101,13561286,248204,13471411,279,149,{"v":5.29871422295e-08,"d":"5.30E-08"},{"v":2.67472329658486e-07,"d":"2.67E-07"},"0.042,0.04","0.09,0.072",-0.04]
[5922,"ENSG00000156650.13","KAT6B","chr10","+",74981786,74985241,74981786,74981928,74985079,74985241,5922,"2,1","71,86","10,8","28,34",298,149,{"v":1.30568988621E-7,"d":"1.31E-07"},{"v":6.27074747982434E-7,"d":"6.27E-07"},"0.014,0.006","0.152,0.105",-0.119]
[5929,"ENSG00000185189.17","NRBP2","chr8","-",143839508,143839825,143839508,143839549,143839735,143839825,5929,"9,29","21,20","56,31","12,3",298,149,{"v":1.62043396084e-05,"d":"1.62E-05"},{"v":5.87840913164052e-05,"d":"5.88E-05"},"0.176,0.42","0.7,0.838",-0.471]
[5940,"ENSG00000115875.18","SRSF7","chr2","-",38748578,38749705,38748578,38748653,38749528,38749705,5940,1057961,39843701,565521,33753500,298,149,{"v":2.63182257343e-06,"d":"2.63E-06"},{"v":1.07285207138533E-5,"d":"1.07E-05"},"0.117,0.115","0.077,0.069",0.043]
[5954,"ENSG00000139625.12","MAP3K12","chr12","-",53486946,53487428,53486946,53487155,53487254,53487428,5954,"24,31","8,0","44,45","8,13",248,149,0.203014583801,0.318425186831384,"0.643,1.0","0.768,0.675",0.1]
[5963,"ENSG00000182796.14","TMEM198B","chr12","+",55832958,55833541,55832958,55833014,55833446,55833541,5963,74101,"3,2","38,70","2,1",298,149,0.706895386174,0.869193730861785,"0.925,0.962","0.905,0.972",0.005]
[5976,"ENSG00000065357.19","DGKA","chr12","+",55951622,55952099,55951622,55951783,55952034,55952099,5976,"2,2","103,79","4,10","43,35",298,149,{"v":5.32861425731e-05,"d":"5.33E-05"},1.77807838614176E-4,"0.01,0.012","0.044,0.125",-0.073]
[5985,"ENSG00000092841.18","MYL6","chr12","+",56158683,56159730,56158683,56158711,56159622,56159730,5985,16151457,"20,18",11181548,"5,6",298,149,0.00115692401122,0.00309273489196557,"0.976,0.976","0.991,0.992",-0.016]
[5994,"ENSG00000135473.14","PAN2","chr12","-",56319087,56319487,56319087,56319181,56319307,56319487,5994,202186,177143,354359,98119,275,149,{"v":9.48541245549E-12,"d":"9.49E-12"},{"v":6.93502035459168e-11,"d":"6.94E-11"},"0.382,0.413","0.662,0.62",-0.244]
[6005,"ENSG00000182199.10","SHMT2","chr12","+",57230802,57231913,57230802,57231000,57231712,57231913,6005,"25,33","5,2","76,50","25,28",298,149,3.18251556822E-3,0.007947913879581,"0.714,0.892","0.603,0.472",0.265]
[6012,"ENSG00000175197.12","DDIT3","chr12","-",57517268,57517753,57517268,57517542,57517705,57517753,6012,110113,"0,0",450491,"0,1",298,149,1,1,"1.0,1.0","1.0,0.996",2E-3]
[6016,"ENSG00000135506.15","OS9","chr12","+",57695961,57696373,57695961,57695976,57696274,57696373,6016,392362,"16,23",375484,"23,14",298,149,0.487442665108,0.658200183818286,"0.925,0.887","0.891,0.945",-0.012]
[6029,"ENSG00000148334.14","PTGES2","chr9","-",128122361,128123134,128122361,128122479,128122933,128123134,6029,176153,433469,116110,341410,298,149,0.175445321994,0.281150980365258,"0.169,0.14","0.145,0.118",0.023]
[6043,"ENSG00000168818.9","STX18","chr4","-",4418967,4420944,4418967,4420129,4420863,4420944,6043,"28,16",201259,"45,45",192233,298,149,1.92571180064E-4,0.000583865974059859,"0.065,0.03","0.105,0.088",-0.049]
[6059,"ENSG00000135596.17","MICAL1","chr6","-",109446135,109446772,109446135,109446412,109446695,109446772,6059,"16,18","94,92","15,13","33,23",298,149,2.12771801838E-3,0.0054661732524164,"0.078,0.089","0.185,0.22",-0.119]
[6065,"ENSG00000142046.14","TMEM91","chr19","+",41382771,41384083,41382771,41382921,41383862,41384083,6065,148160,"47,46","29,27","4,6",298,149,0.102382001391,0.175570146946257,"0.612,0.635","0.784,0.692",-0.115]
[6084,"ENSG00000089053.12","ANAPC5","chr12","-",121318276,121318608,121318276,121318351,121318500,121318608,6084,13491180,"23,15",891780,"3,14",298,149,0.154708999096,0.252006248098359,"0.967,0.975","0.993,0.965",-0.008]
[6093,"ENSG00000198093.10","ZNF649","chr19","-",51899797,51900294,51899797,51899912,51900092,51900294,6093,"38,25","6,0","24,37","0,0",298,149,0.000968252511856,0.00262384818318487,"0.76,1.0","1.0,1.0",-0.12]
[6101,"ENSG00000182196.13","ARL6IP4","chr12","+",122981128,122981879,122981128,122981266,122981570,122981879,6101,423478,241264,473517,557568,298,149,{"v":7.27609472673e-09,"d":"7.28E-09"},{"v":4.04748762934746e-08,"d":"4.05E-08"},"0.467,0.475","0.298,0.313",0.165]
[6105,"ENSG00000182196.13","ARL6IP4","chr12","+",122981956,122982538,122981956,122982074,122982468,122982538,6105,137125,37463437,174179,27653374,298,149,0.000455560668192,1.31008204277032E-3,"0.018,0.018","0.031,0.026",-0.01]
[6119,"ENSG00000185684.14","EP400P1","chr12","+",132103996,132105304,132103996,132104170,132104377,132105304,6119,"30,25","25,22","81,70","10,27",298,149,0.000527830430428,0.00149793982797898,"0.375,0.362","0.802,0.565",-0.315]
[6136,"ENSG00000233325.3","MIPEPP3","chr13","+",21301418,21301618,21301418,21301455,21301481,21301618,6136,"22,30","4,0","14,21","0,2",175,149,0.490005045658,0.661095803709755,"0.824,1.0","1.0,0.899",-0.038]
[6152,"ENSG00000133106.14","EPSTI1","chr13","-",42969093,42970670,42969093,42969177,42970611,42970670,6152,"0,1","16,4","1,1","6,18",298,149,0.571455230465,0.740255273971178,"0.0,0.111","0.077,0.027",0.004]
[6158,"ENSG00000136104.20","RNASEH2B","chr13","+",50959473,50960171,50959473,50959596,50960148,50960171,6158,"6,10","1,0","25,6","0,0",298,149,1,1,"0.75,1.0","1.0,1.0",-0.125]
[6173,"ENSG00000204482.10","LST1","chr6","+",31587199,31588909,31587199,31587318,31588562,31588909,6173,227210,292233,215228,155178,298,149,0.000806081897901,0.00222764042256275,"0.28,0.311","0.41,0.39",-0.105]
[6184,"ENSG00000179335.18","CLK3","chr15","+",74620008,74622216,74620008,74620225,74622119,74622216,6184,"79,64",237232,139135,249251,298,149,0.000155336861454,0.000476823648797817,"0.143,0.121","0.218,0.212",-0.083]
[6186,"ENSG00000134905.16","CARS2","chr13","-",110642314,110644182,110642314,110642521,110644064,110644182,6186,127120,137163,"44,62","38,74",298,149,0.473538599574,0.644191701542038,"0.317,0.269","0.367,0.295",-0.038]
[6198,"ENSG00000100823.11","APEX1","chr14","+",20455577,20456101,20455577,20455703,20455913,20456101,6198,198185,13861195,283316,11911418,298,149,0.000364226250548,1.06223328755393E-3,"0.067,0.072","0.106,0.1",-0.034]
[6213,"ENSG00000196182.10","STK40","chr1","-",36339623,36343448,36339623,36341973,36343363,36343448,6213,"32,33",499493,"56,49",491530,298,149,0.0166554585497,0.0353444323874447,"0.031,0.032","0.054,0.044",-0.018]
[6222,"ENSG00000100462.15","PRMT5","chr14","-",22928125,22928615,22928125,22928241,22928496,22928615,6222,"71,74","1,10","103,77","12,9",298,149,0.224518165236,0.346564311660644,"0.973,0.787","0.811,0.811",0.069]
[6236,"ENSG00000100911.15","PSME2","chr14","-",24144399,24145273,24144399,24145155,24145242,24145273,6236,178179,14411272,177167,871826,236,149,0.000898582819374,0.00245750748007471,"0.072,0.082","0.114,0.113",-0.037]
[6244,"ENSG00000187134.13","AKR1C1","chr10","+",4966926,4968386,4966926,4967043,4968308,4968386,6244,"4,1","52,44","7,0","34,59",298,149,0.49968567119,0.670913556818491,"0.037,0.011","0.093,0.0",-0.022]
[6255,"ENSG00000168701.18","TMEM208","chr16","+",67228796,67229278,67228796,67228836,67228975,67229278,6255,93105,"6,16",160157,"5,5",288,149,1.43998990261E-3,0.00380442766585993,"0.889,0.772","0.943,0.942",-0.112]
[6268,"ENSG00000100906.10","NFKBIA","chr14","-",35402393,35402859,35402393,35402534,35402770,35402859,6268,219166,"12,8",146137,"7,3",298,149,0.264502968766,0.398813659610635,"0.901,0.912","0.912,0.958",-0.028]
[6270,"ENSG00000102316.16","MAGED2","chrX","+",54809721,54810213,54809721,54809817,54809871,54810213,6270,818768,"21,32",10241144,"37,62",203,149,0.108636507434,0.185224659638638,"0.966,0.946","0.953,0.931",0.014]
[6279,"ENSG00000185246.17","PRPF39","chr14","+",45096423,45096758,45096423,45096492,45096595,45096758,6279,248164,"20,10","53,54","0,0",252,149,{"v":1.228997521e-05,"d":"1.23E-05"},{"v":4.55949432145817E-5,"d":"4.56E-05"},"0.88,0.907","1.0,1.0",-0.107]
[6293,"ENSG00000129084.17","PSMA1","chr11","-",14513816,14514491,14513816,14513887,14514402,14514491,6293,1106909,33623325,319349,36663781,298,149,0,0,"0.141,0.12","0.042,0.044",0.088]
[6304,"ENSG00000126822.16","PLEKHG3","chr14","+",64731360,64731806,64731360,64731543,64731713,64731806,6304,"4,20","72,59","16,38","69,91",298,149,0.0349717112551,0.0683499790221392,"0.027,0.145","0.104,0.173",-0.052]
[6319,"ENSG00000100577.18","GSTZ1","chr14","+",77327471,77328037,77327471,77327552,77327911,77328037,6319,"5,2",142150,"15,8","65,78",298,149,{"v":2.40591704737e-06,"d":"2.41E-06"},{"v":9.85844247821299e-06,"d":"9.86E-06"},"0.017,0.007","0.103,0.049",-0.064]
[6320,"ENSG00000100629.16","CEP128","chr14","-",80830164,80831294,80830164,80830283,80831142,80831294,6320,"4,6","0,0","3,9","0,2",298,149,0.737368791135,0.899669558738898,"1.0,1.0","1.0,0.692",0.154]
[6321,"ENSG00000042317.16","SPATA7","chr14","+",88427629,88429463,88427629,88427696,88429347,88429463,6321,"7,0","44,20","3,9","25,32",298,149,0.165420373173,0.267434300070148,"0.074,0.0","0.057,0.123",-0.053]
[6322,"ENSG00000042317.16","SPATA7","chr14","+",88437837,88438455,88437837,88437903,88438326,88438455,6322,"71,27","0,0","45,54","0,4",298,149,0.107755596132,0.183920972534654,"1.0,1.0","1.0,0.871",0.065]
[6323,"ENSG00000100722.19","ZC3H14","chr14","+",88567857,88568153,88567857,88567916,88568038,88568153,6323,"6,13","0,9","46,44","2,0",271,149,0.00454901574008,0.011001569667013,"1.0,0.443","0.927,1.0",-0.242]
[6324,"ENSG00000100722.19","ZC3H14","chr14","+",88609266,88609803,88609266,88609403,88609678,88609803,6324,"48,45","0,0","97,94","1,0",298,149,1,1,"1.0,1.0","0.98,1.0",0.01]
[6325,"ENSG00000100722.19","ZC3H14","chr14","+",88609266,88609803,88609266,88609403,88609711,88609803,6325,"56,49",189197,112114,105131,298,149,{"v":2.21933582623E-13,"d":"2.22E-13"},{"v":1.89743216134438e-12,"d":"1.90E-12"},"0.129,0.111","0.348,0.303",-0.206]
[6326,"ENSG00000100722.19","ZC3H14","chr14","+",88609266,88609803,88609266,88609403,88609714,88609803,6326,"56,51",113110,109114,"54,77",298,149,{"v":3.56252805034E-11,"d":"3.56E-11"},{"v":2.48226073404747E-10,"d":"2.48E-10"},"0.199,0.188","0.502,0.425",-0.27]
[6327,"ENSG00000100722.19","ZC3H14","chr14","+",88609266,88609803,88609266,88609403,88609726,88609803,6327,"76,67","2,4",121136,"1,3",298,149,0.129035523912,0.214757474907906,"0.95,0.893","0.984,0.958",-0.049]
[6328,"ENSG00000165533.18","TTC8","chr14","+",88841036,88841514,88841036,88841196,88841424,88841514,6328,"7,3","12,8","2,1","3,0",298,149,0.788810601655,0.943748437935697,"0.226,0.158","0.25,1.0",-0.433]
[6330,"ENSG00000100764.13","PSMC1","chr14","+",90269396,90270352,90269396,90269548,90270197,90270352,6330,"67,61",23072018,"42,65",22802419,298,149,0.116850927471,0.197105457109809,"0.014,0.015","0.009,0.013",0.003]
[6332,"ENSG00000168268.10","NT5DC2","chr3","-",52527616,52527931,52527616,52527718,52527828,52527931,6332,148140,16131733,343350,336442,259,149,0,0,"0.05,0.044","0.37,0.313",-0.295]
[6333,"ENSG00000015133.18","CCDC88C","chr14","-",91271324,91273653,91271324,91273221,91273359,91273653,6333,91199,"2,3",119127,"3,0",287,149,0.453639040302,0.621217098479939,"0.959,0.972","0.954,1.0",-0.011]
[6334,"ENSG00000166140.17","ZFYVE19","chr15","+",40809851,40810216,40809851,40809970,40810070,40810216,6334,"58,40",206172,"86,86",170171,249,149,1.34426825256E-4,4.1854021380559E-4,"0.144,0.122","0.232,0.231",-0.099]
[6335,"ENSG00000166140.17","ZFYVE19","chr15","+",40813337,40813811,40813337,40813417,40813712,40813811,6335,"39,42",130136,"61,61",135179,298,149,0.189194375827,0.299842122010392,"0.13,0.134","0.184,0.146",-0.033]
[6336,"ENSG00000166140.17","ZFYVE19","chr15","+",40813942,40814569,40813942,40814070,40814147,40814569,6336,"51,58",127127,118127,"111,98",226,149,{"v":1.01889381376e-08,"d":"1.02E-08"},{"v":5.57629889998985e-08,"d":"5.58E-08"},"0.209,0.231","0.412,0.461",-0.216]
[6337,"ENSG00000176438.12","SYNE3","chr14","-",95449930,95452383,95449930,95450105,95452246,95452383,6337,"0,0","20,17","0,1","17,19",298,149,1,1,"0.0,0.0","0.0,0.026",-0.013]
[6338,"ENSG00000104904.12","OAZ1","chr19","+",2271384,2271530,2271384,2271442,2271443,2271530,6338,1036310848,"0,0",1048111463,"0,1",150,149,1,1,"1.0,1.0","1.0,1.0",0]
[6339,"ENSG00000104904.12","OAZ1","chr19","+",2271384,2271954,2271384,2271530,2271781,2271954,6339,223238,91879389,543522,1017910382,298,149,{"v":1.66773816979e-10,"d":"1.67E-10"},{"v":1.07812229096097e-09,"d":"1.08E-09"},"0.012,0.013","0.026,0.025",-0.013]
[6343,"ENSG00000053524.12","MCF2L2","chr3","-",183224097,183228366,183224097,183224190,183228296,183228366,6343,"9,3","10,14","8,23","9,9",298,149,0.028837868507,0.0577365763990358,"0.31,0.097","0.308,0.561",-0.231]
[6344,"ENSG00000214517.9","PPME1","chr11","+",74250953,74251715,74250953,74251018,74251647,74251715,6344,"24,25",450448,"29,20",231189,298,149,1.510806109E-3,0.00398044141432815,"0.026,0.027","0.059,0.05",-0.028]
[6345,"ENSG00000117308.14","GALE","chr1","-",23796508,23796782,23796508,23796586,23796696,23796782,6345,"102,68",568496,"67,60",105136,259,149,{"v":4.17621492943e-12,"d":"4.18E-12"},{"v":3.15041968841738e-11,"d":"3.15E-11"},"0.094,0.073","0.269,0.202",-0.152]
[6346,"ENSG00000117308.14","GALE","chr1","-",23798116,23798730,23798116,23798225,23798614,23798730,6346,"34,45","9,17","87,95","6,8",298,149,{"v":5.5743177946e-05,"d":"5.57E-05"},0.0001854848382565,"0.654,0.57","0.879,0.856",-0.255]
[6347,"ENSG00000117308.14","GALE","chr1","-",23798116,23798730,23798116,23798230,23798614,23798730,6347,"28,40",273247,"86,95",110157,298,149,0,0,"0.049,0.075","0.281,0.232",-0.195]
[6348,"ENSG00000112759.17","SLC29A1","chr6","+",44229906,44230481,44229906,44230046,44230346,44230481,6348,344348,910875,"82,83",346360,298,149,2.11661311144E-4,0.000637671696113193,"0.159,0.166","0.106,0.103",0.058]
[6350,"ENSG00000112759.17","SLC29A1","chr6","+",44232342,44233006,44232342,44232428,44232806,44233006,6350,174183,13431485,235247,343352,298,149,0,0,"0.061,0.058","0.255,0.26",-0.198]
[6351,"ENSG00000185686.17","PRAME","chr22","-",22556811,22557580,22556811,22556909,22557544,22557580,6351,434455,509452,753881,179195,298,149,0,0,"0.299,0.335","0.678,0.693",-0.368]
[6352,"ENSG00000185686.17","PRAME","chr22","-",22556811,22557580,22556811,22556930,22557544,22557580,6352,284304,467474,466583,12571420,298,149,{"v":8.22826338889e-05,"d":"8.23E-05"},2.64878628088758E-4,"0.233,0.243","0.156,0.17",0.075]
[6353,"ENSG00000185686.17","PRAME","chr22","-",22556811,22557580,22556811,22556977,22557544,22557580,6353,230230,"2,4",378507,"2,1",298,149,0.381025100581,0.540174515164877,"0.983,0.966","0.99,0.996",-0.019]
[6354,"ENSG00000185686.17","PRAME","chr22","-",22556811,22557580,22556811,22557086,22557544,22557580,6354,154173,"3,1",275404,"2,0",298,149,0.586115903996,0.753282763938521,"0.963,0.989","0.986,1.0",-0.017]
[6355,"ENSG00000006015.17","REX1BD","chr19","+",18588994,18589683,18588994,18589077,18589412,18589683,6355,324407,255322,682778,99130,298,149,0,0,"0.388,0.387","0.775,0.75",-0.375]
[6356,"ENSG00000006015.17","REX1BD","chr19","+",18588994,18589683,18588994,18589077,18589478,18589683,6356,340483,112110,681793,"25,29",298,149,0,0,"0.603,0.687","0.932,0.932",-0.287]
[6357,"ENSG00000006015.17","REX1BD","chr19","+",18590853,18592336,18590853,18590933,18592088,18592336,6357,"73,81","2,9",193172,"16,26",298,149,0.127379801638,0.212543539646868,"0.948,0.818","0.858,0.768",0.07]
[6358,"ENSG00000006015.17","REX1BD","chr19","+",18590853,18592336,18590853,18590933,18592107,18592336,6358,"73,78",372391,197177,215249,298,149,0,0,"0.089,0.091","0.314,0.262",-0.198]
[6362,"ENSG00000205436.7","EXOC3L4","chr14","+",103110030,103110559,103110030,103110184,103110359,103110559,6362,97139,"0,1","56,90","0,0",298,149,1,1,"1.0,0.986","1.0,1.0",-0.007]
[6363,"ENSG00000145495.15","2024-03-06","chr5","+",10400783,10402139,10400783,10400842,10402058,10402139,6363,567478,589558,400403,448408,298,149,0.791876048002,0.946938469699972,"0.325,0.3","0.309,0.331",-0.008]
[6364,"ENSG00000131591.17","C1orf159","chr1","-",1083914,1084383,1083914,1084011,1084352,1084383,6364,106133,"0,1",94130,"1,4",298,149,0.11225355187,0.19022967986541,"1.0,0.985","0.979,0.942",0.032]
[6365,"ENSG00000131591.17","C1orf159","chr1","-",1083914,1084383,1083914,1084086,1084352,1084383,6365,105107,"12,10","56,86","14,20",298,149,5.58798387625E-3,0.0132508663132465,"0.814,0.843","0.667,0.683",0.153]
[6366,"ENSG00000131591.17","C1orf159","chr1","-",1084352,1084506,1084352,1084383,1084480,1084506,6366,"15,9",165175,"19,16",91153,246,149,0.0135464783834,0.0295803221027303,"0.052,0.03","0.112,0.06",-0.045]
[6367,"ENSG00000131591.17","C1orf159","chr1","-",1090352,1091374,1090352,1090428,1091277,1091374,6367,"21,43","1,0","46,38","2,2",298,149,0.055934328602,0.102991225928013,"0.913,1.0","0.92,0.905",0.044]
[6368,"ENSG00000131591.17","C1orf159","chr1","-",1090352,1091374,1090352,1090587,1091277,1091374,6368,"25,27","0,0","37,25","0,1",298,149,1,1,"1.0,1.0","1.0,0.926",0.037]
[6369,"ENSG00000185215.8","TNFAIP2","chr14","+",103129739,103130124,103129739,103129854,103130001,103130124,6369,"14,11",386364,"6,10",163174,296,149,0.415752495239,0.579171211042028,"0.018,0.015","0.018,0.028",-0.006]
[6370,"ENSG00000167968.12","DNASE1L2","chr16","+",2237375,2237649,2237375,2237476,2237539,2237649,6370,"33,22","0,0","47,33","0,2",212,149,0.533466178433,0.706504260666336,"1.0,1.0","1.0,0.921",0.039]
[6372,"ENSG00000158828.7","PINK1","chr1","+",20648504,20649231,20648504,20648632,20648994,20649231,6372,"15,2","61,76","22,9","84,74",298,149,0.148767482569,0.243162833203549,"0.109,0.013","0.116,0.057",-0.026]
[6374,"ENSG00000185024.16","BRF1","chr14","-",105211121,105212164,105211121,105211293,105212112,105212164,6374,"18,20",125125,"39,21",115153,298,149,0.10893950181,0.185607876512908,"0.067,0.074","0.145,0.064",-0.034]
[6375,"ENSG00000185024.16","BRF1","chr14","-",105219150,105220130,105219150,105219232,105220068,105220130,6375,"11,8",109106,"12,12","115,93",298,149,0.408643360348,0.571474431138007,"0.048,0.036","0.05,0.061",-0.014]
[6376,"ENSG00000185024.16","BRF1","chr14","-",105219150,105220130,105219150,105219298,105220068,105220130,6376,"8,14","3,2","14,10","9,4",298,149,0.127391744311,0.212543539646868,"0.571,0.778","0.437,0.556",0.178]
[6377,"ENSG00000182979.17","MTA1","chr14","+",105450057,105450324,105450057,105450184,105450260,105450324,6377,241245,860818,226211,681827,225,149,0.981843853799,1,"0.157,0.166","0.18,0.145",-1E-3]
[6378,"ENSG00000182979.17","MTA1","chr14","+",105464462,105464863,105464462,105464567,105464673,105464863,6378,"66,97",805939,"37,56",745740,255,149,0.0159332342556,0.0340708411639576,"0.046,0.057","0.028,0.042",0.017]
[6379,"ENSG00000182979.17","MTA1","chr14","+",105469466,105469992,105469466,105469498,105469840,105469992,6379,127121,647666,"60,89",562651,298,149,0.00326911932025,0.00813849484500852,"0.089,0.083","0.051,0.064",0.028]
[6380,"ENSG00000182809.10","CRIP2","chr14","+",105478265,105478507,105478265,105478360,105478449,105478507,6380,"1,0","5,4","0,0","9,4",238,149,1,1,"0.111,0.0","0.0,0.0",0.056]
[6382,"ENSG00000182809.10","CRIP2","chr14","+",105479124,105479493,105479124,105479219,105479435,105479493,6382,"0,2","3,6","0,2","6,10",298,149,0.637713700914,0.802954839664852,"0.0,0.143","0.0,0.091",0.026]
[6384,"ENSG00000160602.13","NEK8","chr17","+",28737305,28737736,28737305,28737579,28737655,28737736,6384,"22,9","2,0","13,26","0,0",225,149,0.523451395273,0.695735818086942,"0.879,1.0","1.0,1.0",-0.06]
[6385,"ENSG00000160602.13","NEK8","chr17","+",28737305,28737736,28737305,28737514,28737674,28737736,6385,"31,14","3,4","39,29","8,5",298,149,0.597603013656,0.765764596218666,"0.838,0.636","0.709,0.744",0.011]
[6386,"ENSG00000012817.15","KDM5D","chrY","-",19706440,19706863,19706440,19706640,19706793,19706863,6386,"62,71",291316,"20,9",128134,298,149,0.00169831693003,0.00443262587073286,"0.096,0.101","0.072,0.032",0.047]
[6387,"ENSG00000180229.12","HERC2P3","chr15","-",20438926,20439655,20438926,20439123,20439507,20439655,6387,123175,167171,258319,"78,94",298,149,0,0,"0.269,0.338","0.623,0.629",-0.323]
[6388,"ENSG00000174652.18","ZNF266","chr19","-",9418761,9419299,9418761,9418895,9419050,9419299,6388,214177,"33,20",339356,"6,12",298,149,{"v":1.45090683912e-09,"d":"1.45E-09"},{"v":8.55223969145888e-09,"d":"8.55E-09"},"0.764,0.816","0.966,0.937",-0.161]
[6390,"ENSG00000104695.12","PPP2CB","chr8","-",30799545,30799755,30799545,30799648,30799716,30799755,6390,12241254,"0,3",14801600,"0,0",217,149,1,1,"1.0,0.997","1.0,1.0",-2E-3]
[6394,"ENSG00000117155.16","SSX2IP","chr1","-",84662197,84662530,84662197,84662375,84662454,84662530,6394,"9,17",288271,"38,28",103127,228,149,{"v":3.95461441371e-13,"d":"3.95E-13"},{"v":3.35082953447392E-12,"d":"3.35E-12"},"0.02,0.039","0.194,0.126",-0.131]
[6395,"ENSG00000117155.16","SSX2IP","chr1","-",84669680,84670815,84669680,84669893,84670645,84670815,6395,"35,37",190195,"65,50",115101,298,149,{"v":1.11222029031E-7,"d":"1.11E-07"},{"v":5.41836270792705E-7,"d":"5.42E-07"},"0.084,0.087","0.22,0.198",-0.124]
[6396,"ENSG00000187994.13","RINL","chr19","-",38871077,38871870,38871077,38871227,38871797,38871870,6396,"49,23","4,1","54,60","17,28",298,149,{"v":1.92953460634E-5,"d":"1.93E-05"},{"v":6.94661738018459e-05,"d":"6.95E-05"},"0.86,0.92","0.614,0.517",0.325]
[6397,"ENSG00000187994.13","RINL","chr19","-",38876330,38876781,38876330,38876474,38876692,38876781,6397,"38,26","2,4","54,62","0,5",298,149,0.253698715566,0.384969749076005,"0.905,0.765","1.0,0.861",-0.096]
[6398,"ENSG00000187994.13","RINL","chr19","-",38876330,38876781,38876330,38876490,38876692,38876781,6398,"35,23","46,39","52,71","40,63",298,149,0.0147243271388,0.0317576964880027,"0.276,0.228","0.394,0.36",-0.125]
[6403,"ENSG00000166471.10","TMEM41B","chr11","-",9280653,9283593,9280653,9281041,9283370,9283593,6403,291247,"70,45",400409,"78,97",298,149,0.914065292785,1,"0.675,0.733","0.719,0.678",0.005]
[6404,"ENSG00000176454.13","LPCAT4","chr15","-",34359588,34360209,34359588,34359745,34360110,34360209,6404,"100,84",127137,"125,96","50,62",298,149,{"v":8.81985135481E-7,"d":"8.82E-07"},{"v":3.82193558708433E-6,"d":"3.82E-06"},"0.282,0.235","0.556,0.436",-0.238]
[6406,"ENSG00000137801.10","THBS1","chr15","+",39593396,39594196,39593396,39593668,39594098,39594196,6406,"1,1","20,18","5,0","112,86",298,149,0.482755423874,0.653875458111145,"0.024,0.027","0.022,0.0",0.015]
[6409,"ENSG00000062524.15","LTK","chr15","-",41504341,41504640,41504341,41504432,41504505,41504640,6409,"16,19",102138,"9,11",78101,222,149,0.33736576687,0.489242226099679,"0.095,0.085","0.072,0.068",0.02]
[6410,"ENSG00000062524.15","LTK","chr15","-",41507094,41507657,41507094,41507290,41507513,41507657,6410,"77,64","3,4","99,75","4,7",298,149,0.557833155431,0.727775178036869,"0.928,0.889","0.925,0.843",0.025]
[6411,"ENSG00000062524.15","LTK","chr15","-",41507094,41507657,41507094,41507174,41507561,41507657,6411,128150,"7,7",159126,"0,0",298,149,{"v":1.41011482796E-5,"d":"1.41E-05"},{"v":5.18681771989938e-05,"d":"5.19E-05"},"0.901,0.915","1.0,1.0",-0.092]
[6412,"ENSG00000062524.15","LTK","chr15","-",41507094,41507657,41507094,41507290,41507561,41507657,6412,"84,73","27,28","97,81","20,16",298,149,0.0302915095197,0.0601394195276052,"0.609,0.566","0.708,0.717",-0.125]
[6413,"ENSG00000159459.11","UBR1","chr15","-",43025373,43026663,43025373,43025429,43026560,43026663,6413,"29,30",266276,"86,86",183202,298,149,{"v":2.0872192863E-14,"d":"2.09E-14"},{"v":1.92682013881196E-13,"d":"1.93E-13"},"0.052,0.052","0.19,0.176",-0.131]
[6414,"ENSG00000166946.13","CCNDBP1","chr15","+",43185819,43186233,43185819,43185879,43186153,43186233,6414,"26,38",268343,"81,76",236222,298,149,{"v":9.035217019e-11,"d":"9.04E-11"},{"v":6.03832461340211e-10,"d":"6.04E-10"},"0.046,0.052","0.146,0.146",-0.097]
[6415,"ENSG00000166946.13","CCNDBP1","chr15","+",43194080,43194461,43194080,43194137,43194414,43194461,6415,"45,58","57,45","86,99","20,36",298,149,{"v":4.45817976102e-06,"d":"4.46E-06"},{"v":1.76725672230909e-05,"d":"1.77E-05"},"0.283,0.392","0.683,0.579",-0.293]
[6416,"ENSG00000137822.12","TUBGCP4","chr15","+",43401715,43403799,43401715,43401850,43403682,43403799,6416,"31,33",203185,123145,"11,15",298,149,0,0,"0.071,0.082","0.848,0.829",-0.762]
[6417,"ENSG00000166710.18","B2M","chr15","+",44715422,44715701,44715422,44715458,44715512,44715701,6417,2273219932,"3,0",2410325140,"3,2",203,149,1,1,"1.0,1.0","1.0,1.0",0]
[6418,"ENSG00000166710.18","B2M","chr15","+",44715422,44716356,44715422,44715701,44716328,44716356,6418,167120,110319272,191143,1213612612,298,149,1,1,"0.008,0.006","0.008,0.006",0]
[6419,"ENSG00000166710.18","B2M","chr15","+",44717606,44718145,44717606,44717791,44717843,44718145,6419,1907917091,365366,1832020001,290325,201,149,0.045347989572,0.0856593194741799,"0.975,0.972","0.979,0.979",-0.005]
[6422,"ENSG00000128951.13","DUT","chr15","+",48341288,48342395,48341288,48341363,48342021,48342395,6422,"68,71","3,2","76,87","4,4",298,149,0.482861876759,0.653875458111145,"0.919,0.947","0.905,0.916",0.022]
[6423,"ENSG00000115282.19","TTC31","chr2","+",74490024,74490473,74490024,74490127,74490243,74490473,6423,142136,231177,"42,51","17,24",265,149,{"v":5.1640205001e-08,"d":"5.16E-08"},{"v":2.61228968795037e-07,"d":"2.61E-07"},"0.257,0.302","0.581,0.544",-0.283]
[6424,"ENSG00000115282.19","TTC31","chr2","+",74490243,74491184,74490243,74490473,74490655,74491184,6424,"68,43",130121,"52,46",124156,298,149,0.238340960585,0.364697793607167,"0.207,0.151","0.173,0.128",0.028]
[6425,"ENSG00000115282.19","TTC31","chr2","+",74490243,74491184,74490243,74490473,74491127,74491184,6425,"86,65","0,0","59,57","4,0",298,149,0.142805780287,0.234630688179298,"1.0,1.0","0.881,1.0",0.059]
[6426,"ENSG00000115282.19","TTC31","chr2","+",74490655,74491184,74490655,74490739,74491127,74491184,6426,"62,42",131105,"50,46",119151,298,149,0.284727582521,0.423767015952113,"0.191,0.167","0.174,0.132",0.026]
[6427,"ENSG00000115282.19","TTC31","chr2","+",74492003,74494559,74492003,74492055,74492138,74494559,6427,"64,39",183199,"65,64",110181,232,149,0.00919206267593,0.0209794792675747,"0.183,0.112","0.275,0.185",-0.083]
[6428,"ENSG00000115282.19","TTC31","chr2","+",74492138,74492445,74492138,74492229,74492303,74492445,6428,"63,52","115,95",130154,"65,68",223,149,{"v":7.29416527179e-14,"d":"7.29E-14"},{"v":6.4452167997474e-13,"d":"6.45E-13"},"0.268,0.268","0.572,0.602",-0.319]
[6429,"ENSG00000092439.14","TRPM7","chr15","-",50575723,50575919,50575723,50575789,50575868,50575919,6429,"31,62",298275,"24,13",208239,228,149,0.00202565022963,0.00522091816382093,"0.064,0.128","0.07,0.034",0.044]
[6432,"ENSG00000186654.20","PRR5","chr22","+",44702217,44702608,44702217,44702409,44702491,44702608,6432,"31,41","4,0","8,13","0,6",231,149,0.115636900049,0.19526586858808,"0.833,1.0","1.0,0.583",0.125]
[6433,"ENSG00000177830.17","CHID1","chr11","-",869213,869956,869213,869345,869857,869956,6433,167209,"3,1",126139,"0,3",298,149,0.902910146082,1,"0.965,0.991","1.0,0.959",-2E-3]
[6434,"ENSG00000171914.16","TLN2","chr15","+",62753772,62755693,62753772,62753916,62755531,62755693,6434,"0,0","22,12","1,0","3,7",298,149,1,1,"0.0,0.0","0.143,0.0",-0.071]
[6435,"ENSG00000185088.13","RPS27L","chr15","-",63153852,63155731,63153852,63154060,63155620,63155731,6435,"27,8",928836,"33,53",682737,298,149,{"v":3.47320542216e-07,"d":"3.47E-07"},{"v":1.58923430358237e-06,"d":"1.59E-06"},"0.014,0.005","0.024,0.035",-0.02]
[6437,"ENSG00000174444.14","RPL4","chr15","-",66500948,66501504,66500948,66501105,66501374,66501504,6437,383305,1931517804,443430,2209120996,298,149,1,1,"0.01,0.008","0.01,0.01",-1E-3]
[6438,"ENSG00000174444.14","RPL4","chr15","-",66502611,66503164,66502611,66502750,66503057,66503164,6438,532499,1423313938,322305,1836819493,298,149,{"v":2.64789880022e-08,"d":"2.65E-08"},{"v":1.38985396095618e-07,"d":"1.39E-07"},"0.018,0.018","0.009,0.008",0.009]
[6439,"ENSG00000174444.14","RPL4","chr15","-",66503057,66503529,66503057,66503164,66503357,66503529,6439,151145,2150420787,191217,2392726453,298,149,1,1,"0.003,0.003","0.004,0.004",-1E-3]
[6441,"ENSG00000005007.12","UPF1","chr19","+",18865288,18865778,18865288,18865450,18865560,18865778,6441,"13,9",774765,"7,2",629634,259,149,1,1,"0.01,0.007","0.006,0.002",0.005]
[6442,"ENSG00000145020.15","AMT","chr3","-",49416777,49417718,49416777,49417367,49417614,49417718,6442,"44,27","0,0","76,58","5,0",298,149,0.0411310017175,0.0787915232739352,"1.0,1.0","0.884,1.0",0.058]
[6443,"ENSG00000145020.15","AMT","chr3","-",49416793,49417718,49416793,49417357,49417614,49417718,6443,"44,27","0,0","77,59","2,0",298,149,0.404294318554,0.566418523598308,"1.0,1.0","0.951,1.0",0.024]
[6444,"ENSG00000145020.15","AMT","chr3","-",49416821,49417718,49416821,49417309,49417614,49417718,6444,"48,33","0,1","78,56","0,0",298,149,1,1,"1.0,0.943","1.0,1.0",-0.028]
[6445,"ENSG00000145020.15","AMT","chr3","-",49418970,49419405,49418970,49419151,49419259,49419405,6445,"5,23","17,17","8,9","11,12",257,149,0.906902662047,1,"0.146,0.44","0.297,0.303",-0.007]
[6446,"ENSG00000145020.15","AMT","chr3","-",49418970,49420342,49418970,49419151,49419709,49420342,6446,"20,10","1,4","8,13","0,0",298,149,0.000612148612327,1.71567936532286E-3,"0.909,0.556","1.0,1.0",-0.267]
[6447,"ENSG00000145020.15","AMT","chr3","-",49419259,49420342,49419259,49419335,49419709,49420342,6447,"28,26","0,2","19,21","0,0",298,149,0.69788498429,0.861239076841625,"1.0,0.867","1.0,1.0",-0.067]
[6448,"ENSG00000145020.15","AMT","chr3","-",49418970,49421572,49418970,49420342,49421491,49421572,6448,"3,9","18,16","18,23","28,58",298,149,0.307560274285,0.453080875964708,"0.077,0.22","0.243,0.165",-0.056]
[6449,"ENSG00000145020.15","AMT","chr3","-",49422103,49422451,49422103,49422271,49422360,49422451,6449,"19,13","2,0","18,17","1,1",238,149,0.512207135415,0.684048088247727,"0.856,1.0","0.918,0.914",0.012]
[6452,"ENSG00000103653.16","CSK","chr15","+",74800411,74800746,74800411,74800505,74800680,74800746,6452,"67,94",16671473,152176,9501005,298,149,0,0,"0.02,0.031","0.074,0.081",-0.052]
[6453,"ENSG00000103653.16","CSK","chr15","+",74800680,74800922,74800680,74800746,74800822,74800922,6453,"44,23",12061072,96119,770939,225,149,0,0,"0.024,0.014","0.076,0.077",-0.057]
[6454,"ENSG00000103653.16","CSK","chr15","+",74801694,74802083,74801694,74801890,74801996,74802083,6454,"28,55",19832036,"69,50",14761468,255,149,0.000126280167681,0.000395839329238249,"0.008,0.016","0.027,0.02",-0.011]
[6455,"ENSG00000140474.13","ULK3","chr15","-",74840233,74840641,74840233,74840316,74840497,74840641,6455,510551,249216,427411,111133,298,149,0.00239067149173,6.07917268395436E-3,"0.506,0.561","0.658,0.607",-0.099]
[6456,"ENSG00000140474.13","ULK3","chr15","-",74842074,74842420,74842074,74842118,74842279,74842420,6456,473485,"32,24",452476,"31,26",298,149,0.821827252805,0.972703994651964,"0.881,0.91","0.879,0.902",0.005]
[6457,"ENSG00000140474.13","ULK3","chr15","-",74842074,74842420,74842074,74842195,74842279,74842420,6457,"67,64",577542,208187,299342,233,149,0,0,"0.069,0.07","0.308,0.259",-0.214]
[6458,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842676,74842279,74842417,74842534,74842676,6458,"36,51","1,1",156144,"3,1",266,149,0.556917985302,0.726980973936173,"0.953,0.966","0.967,0.988",-0.018]
[6459,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842676,74842279,74842420,74842534,74842676,6459,"30,43","51,46",155143,"43,61",263,149,{"v":3.01618644505e-08,"d":"3.02E-08"},{"v":1.56927682914059e-07,"d":"1.57E-07"},"0.25,0.346","0.671,0.57",-0.323]
[6460,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842676,74842279,74842449,74842534,74842676,6460,"28,34","0,0",135125,"0,5",234,149,0.380330892611,0.539512731073003,"1.0,1.0","1.0,0.941",0.03]
[6461,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842676,74842279,74842417,74842538,74842676,6461,"36,52","1,0",157148,"0,0",270,149,1,1,"0.952,1.0","1.0,1.0",-0.024]
[6462,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842676,74842279,74842420,74842538,74842676,6462,"30,44","21,27",155147,"22,7",267,149,{"v":1.45446987787E-10,"d":"1.45E-10"},{"v":9.454054206155e-10,"d":"9.45E-10"},"0.444,0.476","0.797,0.921",-0.399]
[6463,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842676,74842279,74842449,74842538,74842676,6463,"28,35","0,0",136129,"2,1",238,149,0.575800036686,0.742437819042138,"1.0,1.0","0.977,0.988",0.018]
[6464,"ENSG00000140497.16","SCAMP2","chr15","-",74852068,74854119,74852068,74852186,74854020,74854119,6464,"46,50",8481025,"40,52",809891,298,149,0.798489862676,0.952686547246069,"0.026,0.024","0.024,0.028",-1E-3]
[6465,"ENSG00000178761.14","FAM219B","chr15","-",74899991,74902063,74899991,74900137,74901949,74902063,6465,287354,"27,53",521578,"11,16",298,149,{"v":6.18649576012e-12,"d":"6.19E-12"},{"v":4.57955107359897e-11,"d":"4.58E-11"},"0.842,0.77","0.959,0.948",-0.147]
[6466,"ENSG00000178761.14","FAM219B","chr15","-",74899991,74902786,74899991,74900137,74902603,74902786,6466,232285,"13,11",412532,"1,12",298,149,0.000476447602009,1.36435960864979E-3,"0.899,0.928","0.995,0.957",-0.062]
[6467,"ENSG00000178761.14","FAM219B","chr15","-",74899991,74902786,74899991,74902063,74902603,74902786,6467,226233,"76,57",517603,"9,5",298,149,0,0,"0.598,0.671","0.966,0.984",-0.34]
[6468,"ENSG00000178761.14","FAM219B","chr15","-",74904663,74905231,74904663,74904712,74905153,74905231,6468,140119,251274,"114,70",255262,298,149,0.0278112672152,0.0558934616417297,"0.218,0.178","0.183,0.118",0.048]
[6469,"ENSG00000178761.14","FAM219B","chr15","-",74904663,74906365,74904663,74904712,74906277,74906365,6469,"89,67","0,1","71,51","0,0",298,149,1,1,"1.0,0.971","1.0,1.0",-0.014]
[6470,"ENSG00000178761.14","FAM219B","chr15","-",74904663,74906365,74904663,74905231,74906277,74906365,6470,"28,50",129146,"52,80",125159,298,149,0.00916778792618,0.02093414519236,"0.098,0.146","0.172,0.201",-0.065]
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[20,"ENSG00000130830.14","MPP1","chrX","-",154781238,154781313,154781599,154781802,154778683,154779353,154783426,154783507,20,10861144,1081913,9611012,785793,298,224,0.32475779,0.5118534055367,"0.43,0.485","0.479,0.49",-0.027]
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[154,"ENSG00000147099.20","HDAC8","chrX","-",72488932,72489041,72490928,72491006,72464558,72464731,72567888,72568030,154,"0,0",138129,"4,4","40,53",227,258,0.000301725810162,0.00145826569768336,"0.0,0.0","0.102,0.079",-0.09]
[155,"ENSG00000147099.20","HDAC8","chrX","-",72488932,72489041,72495155,72495268,72464558,72464731,72567888,72568030,155,97122,138129,"48,62","40,53",262,258,0.0628736722665,0.144878324495537,"0.409,0.482","0.542,0.535",-0.093]
[156,"ENSG00000147099.20","HDAC8","chrX","-",72488932,72489041,72495155,72495268,72473415,72474729,72567888,72568030,156,97122,"41,26","33,58","9,2",262,258,0.0138895051127,0.0414123262177887,"0.7,0.822","0.783,0.966",-0.114]
[157,"ENSG00000147099.20","HDAC8","chrX","-",72490928,72491006,72495155,72495268,72464558,72464731,72567888,72568030,157,97122,"0,0","48,62","4,4",262,227,0.000746513120391,0.00329795937223994,"1.0,1.0","0.912,0.931",0.079]
[158,"ENSG00000147099.20","HDAC8","chrX","-",72490928,72491006,72495155,72495268,72488932,72489041,72567888,72568030,158,105136,"101,98","35,68","49,42",262,227,0.731110850926,0.880840460211619,"0.474,0.546","0.382,0.584",0.027]
[159,"ENSG00000147099.20","HDAC8","chrX","-",72490928,72491006,72567888,72568030,72488932,72489041,72572056,72572095,159,"1,1","101,98","21,30","44,41",291,227,0,0,"0.008,0.008","0.271,0.363",-0.309]
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[162,"ENSG00000147099.20","HDAC8","chrX","-",72495155,72495268,72567888,72568030,72490928,72491006,72568753,72568884,162,181177,193188,"103,78","42,64",291,262,0.01264307231,0.0382338077703082,"0.458,0.459","0.688,0.523",-0.147]
[163,"ENSG00000147099.20","HDAC8","chrX","-",72567888,72568030,72568753,72568884,72495155,72495268,72572056,72572109,163,224213,141153,143146,"62,98",280,291,0.243796113182,0.415618730431438,"0.623,0.591","0.706,0.608",-0.05]
[164,"ENSG00000147099.20","HDAC8","chrX","-",72568753,72568884,72572056,72572109,72495155,72495268,72572650,72572843,164,"91,77","2,0","100,98","0,0",202,280,1,1,"0.984,1.0","1.0,1.0",-0.008]
[165,"ENSG00000147133.15","TAF1","chrX","+",71388236,71388378,71388737,71388868,71387260,71387461,71389584,71389665,165,132125,164194,149131,139131,291,280,0.0177401383604,0.051120491342313,"0.436,0.383","0.508,0.49",-0.09]
[166,"ENSG00000147133.15","TAF1","chrX","+",71424153,71424238,71454169,71454237,71423973,71424066,71454740,71454857,166,167185,141144,176171,"137,98",234,217,0.243309358636,0.415040842635308,"0.523,0.544","0.544,0.618",-0.047]
[167,"ENSG00000184634.15","MED12","chrX","+",71125662,71125713,71126035,71126154,71125350,71125495,71126340,71126484,167,161107,228234,"30,37",156154,200,268,{"v":1.39547413369e-06,"d":"1.40E-06"},{"v":1.06143900845905e-05,"d":"1.06E-05"},"0.486,0.38","0.205,0.244",0.209]
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[177,"ENSG00000102043.15","MTMR8","chrX","-",64337267,64337393,64348659,64348794,64336078,64336128,64349941,64350070,177,"46,31","7,16","53,47","6,7",284,275,0.0538503391127,0.127970731837467,"0.864,0.652","0.895,0.867",-0.123]
[178,"ENSG00000102043.15","MTMR8","chrX","-",64354776,64354934,64359404,64359527,64349941,64350070,64395339,64395431,178,"7,14","46,34","9,18","54,71",272,298,0.627726001495,0.800273200026828,"0.143,0.311","0.154,0.217",0.041]
[179,"ENSG00000169188.4","APEX2","chrX","+",55001545,55001629,55002961,55003108,55000356,55000579,55003798,55003868,179,258184,662799,189208,646658,233,296,0.942930955504,1,"0.331,0.226","0.271,0.287",-1E-3]
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[181,"ENSG00000130119.15","GNL3L","chrX","+",54544222,54544326,54548228,54548373,54543206,54543342,54550962,54551050,181,502450,420446,232272,218228,253,294,0.8337001776,0.954552290684841,"0.581,0.54","0.553,0.581",-0.006]
[182,"ENSG00000130119.15","GNL3L","chrX","+",54551567,54551742,54551831,54551974,54550962,54551050,54552291,54552428,182,490542,602686,327332,220218,298,292,{"v":4.12601676603e-07,"d":"4.13E-07"},{"v":3.39587804820249E-6,"d":"3.40E-06"},"0.444,0.436","0.593,0.599",-0.156]
[183,"ENSG00000172943.19","PHF8","chrX","-",53987765,53987944,53992735,53992839,53987077,53987163,53993600,53993903,183,221178,446377,133140,268333,253,298,0.656137646153,0.824282783051272,"0.369,0.357","0.369,0.331",0.013]
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[187,"ENSG00000086758.15","HUWE1","chrX","-",53543840,53543968,53545028,53545161,53542442,53542539,53546435,53546592,187,782801,373399,401354,134161,282,277,0.083194407423,0.181908830321855,"0.673,0.664","0.746,0.684",-0.046]
[188,"ENSG00000086758.15","HUWE1","chrX","-",53543885,53543968,53544559,53544762,53542442,53542539,53545028,53545161,188,562598,291252,232202,"63,68",298,232,3.07939860904E-3,0.0114365301399206,"0.601,0.649","0.741,0.698",-0.095]
[189,"ENSG00000086758.15","HUWE1","chrX","-",53543885,53543968,53545028,53545161,53542442,53542539,53546435,53546592,189,782801,279246,401354,"59,63",282,232,{"v":7.45218041609e-07,"d":"7.45E-07"},{"v":5.94824304686061e-06,"d":"5.95E-06"},"0.698,0.728","0.848,0.822",-0.122]
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[191,"ENSG00000086758.15","HUWE1","chrX","-",53554632,53554920,53557381,53557427,53552637,53552893,53558654,53558809,191,149101,495530,111134,497410,195,298,0.499447122989,0.687468521326368,"0.315,0.226","0.254,0.333",-0.023]
[192,"ENSG00000086758.15","HUWE1","chrX","-",53607522,53607699,53608851,53608909,53604588,53604834,53614533,53614745,192,118128,806904,"81,66",408383,207,298,0.0987752191908,0.208509996241834,"0.174,0.169","0.222,0.199",-0.039]
[193,"ENSG00000086758.15","HUWE1","chrX","-",53631413,53631482,53632486,53632564,53630934,53631034,53634235,53634298,193,415465,215186,269256,151135,227,218,0.200422512333,0.35928621586167,"0.65,0.706","0.631,0.646",0.039]
[194,"ENSG00000086758.15","HUWE1","chrX","-",53680048,53680186,53686269,53686368,53654062,53654131,53686587,53686728,194,"52,48",565569,"51,50",362386,248,287,0.0180681156114,0.0519266332730041,"0.096,0.089","0.14,0.13",-0.043]
[195,"ENSG00000072506.12","HSD17B10","chrX","-",53432246,53432411,53433721,53433886,53431987,53432116,53434318,53434350,195,580450,17681673,467529,13311519,298,298,0.153962749074,0.29469196770966,"0.247,0.212","0.26,0.258",-0.03]
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[317,"ENSG00000196576.14","PLXNB2","chr22","-",50284572,50284665,50285799,50285901,50284131,50284213,50285989,50286098,317,116106,112107,"45,60","80,77",251,242,0.0286016287292,0.0760802646994666,"0.5,0.489","0.352,0.429",0.104]
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[319,"ENSG00000100429.17","HDAC10","chr22","-",50248365,50248472,50248661,50248751,50248224,50248292,50248830,50248890,319,94115,134167,"55,59",87131,239,256,0.130808851816,0.259595839202764,"0.429,0.424","0.404,0.325",0.062]
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[330,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248859,50249102,50249168,50248661,50248751,50249327,50249454,330,82102,"22,20","29,11","30,22",215,178,{"v":2.99789583158e-08,"d":"3.00E-08"},{"v":2.90970718962293e-07,"d":"2.91E-07"},"0.755,0.809","0.445,0.293",0.413]
[331,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248859,50249327,50249454,50248661,50248751,50249634,50249703,331,171196,"19,17",187177,"11,9",276,178,0.044848137816,0.110022143092881,"0.853,0.881","0.916,0.927",-0.054]
[332,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248859,50249327,50249516,50248661,50248751,50249634,50249703,332,"18,15","19,17","17,6","11,9",298,178,0.713746910917,0.868470667247594,"0.361,0.345","0.48,0.285",-0.029]
[333,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248890,50249102,50249168,50248661,50248751,50249327,50249454,333,82102,"40,38","29,11","23,28",215,209,0.00334831407786,0.0122910094780977,"0.666,0.723","0.551,0.276",0.281]
[334,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248890,50249327,50249454,50248661,50248751,50249634,50249703,334,171196,"38,39",187177,"23,28",276,209,0.0588799605295,0.137296285056758,"0.773,0.792","0.86,0.827",-0.061]
[335,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248890,50249327,50249516,50248661,50248751,50249634,50249703,335,"18,15","38,39","17,6","23,28",298,209,0.944417676377,1,"0.249,0.212","0.341,0.131",-0.006]
[336,"ENSG00000100429.17","HDAC10","chr22","-",50250062,50250160,50250426,50250523,50249859,50249964,50250770,50250905,336,131141,242296,"64,55",199253,246,247,{"v":4.67160685568e-05,"d":"4.67E-05"},2.69905719825852E-4,"0.352,0.324","0.244,0.179",0.126]
[337,"ENSG00000170638.9","TRABD","chr22","+",50194899,50195040,50197240,50197351,50194339,50194506,50197448,50197588,337,261257,434466,203269,266314,290,260,0.00846164017463,0.0272306778979893,"0.35,0.331","0.406,0.434",-0.08]
[338,"ENSG00000100427.15","MLC1","chr22","-",50070526,50070583,50074215,50074332,50068432,50068555,50076840,50076912,338,782831,239282,388482,"84,94",266,206,0.000947805567513,0.00408130381304131,"0.717,0.695","0.782,0.799",-0.085]
[339,"ENSG00000100427.15","MLC1","chr22","-",50079917,50080019,50080343,50080397,50077400,50077502,50083083,50083173,339,277265,10661122,375379,257317,203,251,0,0,"0.243,0.226","0.643,0.596",-0.385]
[340,"ENSG00000100427.15","MLC1","chr22","-",50080343,50080397,50083083,50083173,50077400,50077502,50084725,50084961,340,393500,"15,15",307335,112142,239,203,0,0,"0.957,0.966","0.7,0.667",0.278]
[341,"ENSG00000100427.15","MLC1","chr22","-",50080343,50080397,50083083,50083173,50079917,50080019,50084725,50084961,341,388503,670648,304332,168198,239,203,{"v":2.06390460278E-13,"d":"2.06E-13"},{"v":3.60045594098321e-12,"d":"3.60E-12"},"0.33,0.397","0.606,0.587",-0.233]
[342,"ENSG00000184164.14","CRELD2","chr22","+",49919229,49919312,49919729,49919840,49918634,49918898,49920155,49920247,342,"66,70",168184,"40,37","91,89",232,260,0.628065131946,0.800544330025792,"0.306,0.299","0.33,0.318",-0.022]
[343,"ENSG00000184164.14","CRELD2","chr22","+",49923233,49923317,49924359,49924455,49922611,49922707,49925416,49925557,343,116161,367336,"98,85",116131,233,245,0.000184147879726,0.000935055075607569,"0.249,0.335","0.47,0.406",-0.146]
[344,"ENSG00000054611.13","TBC1D22A","chr22","+",46793500,46793841,46878652,46878723,46762680,46762848,46891265,46891394,344,"0,0",155153,"1,2",161142,298,220,1,1,"0.0,0.0","0.005,0.01",-0.007]
[345,"ENSG00000054611.13","TBC1D22A","chr22","+",46797443,46797620,46878652,46878723,46793500,46793841,46891265,46891394,345,142139,156154,97116,185176,298,220,0.00544941101861,0.0186707557452192,"0.402,0.4","0.279,0.327",0.098]
[346,"ENSG00000054611.13","TBC1D22A","chr22","+",46878652,46878723,46891265,46891394,46797443,46797620,46912073,46912188,346,"47,49","2,0","39,33","8,14",220,278,{"v":2.23541419597e-07,"d":"2.24E-07"},{"v":1.91529082912788e-06,"d":"1.92E-06"},"0.967,1.0","0.86,0.749",0.179]
[347,"ENSG00000054611.13","TBC1D22A","chr22","+",46894783,46894846,46912073,46912188,46891265,46891394,46974289,46974399,347,94121,144123,"81,82",97112,212,264,0.882525444495,0.986835085715047,"0.448,0.551","0.51,0.477",0.006]
[348,"ENSG00000054611.13","TBC1D22A","chr22","+",46912073,46912188,46974289,46974399,46894783,46894846,46997633,46997709,348,180225,152190,212255,125136,264,259,4.77289334092E-3,0.0166654452955915,"0.537,0.537","0.625,0.648",-0.1]
[349,"ENSG00000054611.13","TBC1D22A","chr22","+",46912073,46912188,46997633,46997709,46894783,46894846,47037070,47037198,349,173219,160201,186230,132129,264,225,0.00920283103015,0.0292068659024882,"0.48,0.481","0.546,0.603",-0.094]
[350,"ENSG00000054611.13","TBC1D22A","chr22","+",46913333,46913446,46974289,46974399,46912073,46912188,46997633,46997709,350,"0,1",334340,"1,0",271266,262,259,1,1,"0.0,0.003","0.004,0.0",-1E-3]
[351,"ENSG00000054611.13","TBC1D22A","chr22","+",46974289,46974399,46997633,46997709,46912073,46912188,47037070,47037198,351,143109,167207,118101,155154,259,225,0.790558988198,0.924630154901924,"0.427,0.314","0.398,0.363",-0.01]
[352,"ENSG00000054611.13","TBC1D22A","chr22","+",46974289,46974399,47037070,47037198,46912073,46912188,47111507,47111603,352,142109,195156,116105,107106,259,277,0.0204257033323,0.0576057648014872,"0.438,0.428","0.537,0.514",-0.093]
[353,"ENSG00000054611.13","TBC1D22A","chr22","+",46997633,46997709,47037070,47037198,46974289,46974399,47111507,47111603,353,108115,196156,"91,89",108102,225,277,0.0782314177396,0.173044076116467,"0.404,0.476","0.509,0.518",-0.074]
[354,"ENSG00000054611.13","TBC1D22A","chr22","+",46997633,46997709,47111507,47111603,46974289,46974399,47173497,47174083,354,96114,160118,"75,81","91,72",225,245,0.273995664882,0.45347735667602,"0.395,0.513","0.473,0.551",-0.058]
[355,"ENSG00000054611.13","TBC1D22A","chr22","+",47037070,47037198,47111507,47111603,46997633,46997709,47173497,47174083,355,191210,172118,168169,"111,79",277,245,0.216338441824,0.380412306256335,"0.496,0.612","0.572,0.654",-0.059]
[356,"ENSG00000100416.13","TRMU","chr22","+",46350290,46350463,46355443,46355588,46346421,46346544,46356841,46357016,356,132102,"24,12",500536,76109,298,294,0.394875264303,0.586569635966158,"0.844,0.893","0.867,0.829",0.021]
[357,"ENSG00000100416.13","TRMU","chr22","+",46350345,46350463,46355443,46355588,46346421,46346544,46356841,46357337,357,"80,87","24,12","18,13",76109,267,294,0,0,"0.786,0.889","0.207,0.116",0.676]
[358,"ENSG00000100416.13","TRMU","chr22","+",46350349,46350463,46355443,46355588,46346421,46346544,46356841,46357337,358,"30,46","24,12","10,6",76109,263,294,{"v":3.33066907388e-16,"d":"3.33E-16"},{"v":7.64420872533296e-15,"d":"7.64E-15"},"0.583,0.811","0.128,0.058",0.604]
[359,"ENSG00000100416.13","TRMU","chr22","+",46352263,46352330,46353766,46353867,46352120,46352174,46355443,46355588,359,157196,104104,298320,179241,216,250,0.352915237465,0.542643705645732,"0.636,0.686","0.658,0.606",0.029]
[360,"ENSG00000130638.16","ATXN10","chr22","+",45689711,45689903,45718412,45718493,45671798,45672179,45729424,45729590,360,461538,662670,438440,446418,298,230,0.00980570984106,0.0307543962058594,"0.35,0.383","0.431,0.448",-0.073]
[361,"ENSG00000130638.16","ATXN10","chr22","+",45692995,45693078,45700281,45700378,45671797,45672179,45702688,45702847,361,"0,1",530546,"5,4",340369,232,246,0.731431939849,0.881161560048639,"0.0,0.002","0.015,0.011",-0.012]
[362,"ENSG00000130638.16","ATXN10","chr22","+",45692995,45693078,45718412,45718493,45671797,45672179,45729424,45729590,362,"0,0",662670,"5,4",446418,232,230,1,1,"0.0,0.0","0.011,0.009",-0.01]
[363,"ENSG00000248405.10","PRR5-ARHGAP8","chr22","+",44714590,44714671,44725243,44725292,44702232,44702608,44726576,44726634,363,"50,77","35,42","81,78","52,49",230,198,0.843923261415,0.961713838856501,"0.552,0.612","0.573,0.578",0.007]
[364,"ENSG00000248405.10","PRR5-ARHGAP8","chr22","+",44731729,44731821,44732250,44732391,44726576,44726634,44735026,44735162,364,"59,71",114125,"34,45","53,43",241,290,0.0858926914271,0.186375942411927,"0.384,0.406","0.436,0.557",-0.102]
[366,"ENSG00000100243.20","CYB5R3","chr22","-",42623788,42623888,42627303,42627389,42617839,42619945,42627604,42627688,366,494460,12521148,468461,874834,235,249,0.00624540783843,0.0209426770464162,"0.295,0.298","0.362,0.369",-0.069]
[367,"ENSG00000100227.17","POLDIP3","chr22","-",42587505,42587572,42591954,42592084,42583720,42585968,42595536,42595603,367,618479,327295,777861,336404,279,216,0.0523768987351,0.1249449556937,"0.594,0.557","0.642,0.623",-0.057]
[368,"ENSG00000100227.17","POLDIP3","chr22","-",42591954,42592084,42595536,42595603,42587505,42587572,42596185,42596365,368,"6,0",693729,"10,19",900805,216,279,0.00498464972026,0.0173053298152846,"0.011,0.0","0.014,0.03",-0.017]
[369,"ENSG00000100227.17","POLDIP3","chr22","-",42591954,42592084,42595536,42595614,42587505,42587572,42596185,42596365,369,469370,693729,488527,900805,227,279,0.907137809779,1,"0.454,0.384","0.4,0.446",-0.004]
[370,"ENSG00000100227.17","POLDIP3","chr22","-",42599697,42599793,42601969,42602056,42596185,42596365,42602769,42603160,370,415393,614593,281258,12281175,236,245,0,0,"0.412,0.408","0.192,0.186",0.221]
[371,"ENSG00000100227.17","POLDIP3","chr22","-",42599697,42599793,42601969,42602107,42596185,42596365,42602769,42603160,371,"2,11",614593,"1,0",12281175,287,245,0.878065792409,0.984250160324574,"0.003,0.016","0.001,0.0",0.009]
[372,"ENSG00000198951.11","NAGA","chr22","-",42065737,42065899,42066709,42066804,42062826,42063024,42067112,42067290,372,234267,425395,104110,131134,244,298,0.057897710905,0.135539035874603,"0.402,0.452","0.492,0.501",-0.069]
[373,"ENSG00000100147.13","CCDC134","chr22","+",41810206,41810291,41813263,41813445,41809878,41810000,41813750,41813822,373,"89,31","58,59","56,90","69,60",234,298,0.615564057543,0.789536979617174,"0.661,0.401","0.508,0.656",-0.051]
[374,"ENSG00000100147.13","CCDC134","chr22","+",41810206,41810291,41813750,41813822,41809878,41810000,41825697,41826299,374,"89,31","25,36","57,88","42,26",234,221,0.701011828459,0.858975556178506,"0.771,0.449","0.562,0.762",-0.052]
[375,"ENSG00000100147.13","CCDC134","chr22","+",41813263,41813445,41813750,41813822,41810206,41810291,41825697,41826299,375,"94,90","25,36","75,90","42,28",298,221,0.36102116558,0.551822079552178,"0.736,0.65","0.57,0.704",0.056]
[376,"ENSG00000196419.12","XRCC6","chr22","+",41637607,41637791,41646895,41647082,41636515,41636770,41650722,41650891,376,50964872,39553579,42134590,34203468,298,298,0.724968145961,0.8762496944698,"0.563,0.576","0.552,0.57",0.008]
[377,"ENSG00000196419.12","XRCC6","chr22","+",41653528,41653690,41656902,41657032,41650722,41650891,41658251,41658352,377,46964656,67826232,39784507,52485244,298,279,0.259379176368,0.435422268212932,"0.393,0.412","0.415,0.446",-0.028]
[378,"ENSG00000196419.12","XRCC6","chr22","+",41656902,41657032,41658251,41658352,41653528,41653690,41661330,41661444,378,53284841,31972899,42174241,27913125,279,250,0.137805169618,0.270305050733028,"0.599,0.599","0.575,0.549",0.037]
[379,"ENSG00000196419.12","XRCC6","chr22","+",41656902,41657032,41661330,41661444,41653528,41653690,41663621,41664034,379,53254842,30033013,42174239,23972556,279,263,0.912341204664,1,"0.626,0.602","0.624,0.61",-0.003]
[380,"ENSG00000196419.12","XRCC6","chr22","+",41658251,41658352,41661330,41661444,41656902,41657032,41663621,41664034,380,57735318,29983009,42884197,24002557,250,263,0.471607508749,0.661498789817172,"0.67,0.65","0.653,0.633",0.017]
[381,"ENSG00000100418.7","DESI1","chr22","-",41604043,41604153,41607261,41607331,41603258,41603381,41607839,41607861,381,"50,34",253247,"6,2","34,24",219,259,0.345786313465,0.535382626601783,"0.189,0.14","0.173,0.09",0.033]
[382,"ENSG00000100418.7","DESI1","chr22","-",41607261,41607331,41607839,41607861,41604043,41604153,41620751,41621096,382,"7,11","122,94","1,1","10,18",171,219,0.252774393971,0.427422325265984,"0.068,0.13","0.114,0.066",0.009]
[383,"ENSG00000100410.7","PHF5A","chr22","-",41467447,41467614,41468123,41468147,41459716,41460487,41468601,41468725,383,"4,0",753726,"4,2",630673,173,298,1,1,"0.009,0.0","0.011,0.005",-0.004]
[384,"ENSG00000100401.19","RANGAP1","chr22","-",41249329,41249451,41252871,41252991,41245610,41246672,41254307,41254494,384,887844,574617,697741,598558,269,271,0.172233795856,0.32083093741913,"0.609,0.579","0.54,0.572",0.038]
[385,"ENSG00000100401.19","RANGAP1","chr22","-",41256190,41256290,41256710,41256824,41256020,41256105,41257947,41258106,385,641565,521387,528581,393422,263,249,0.88521988265,0.988470606463713,"0.538,0.58","0.56,0.566",-0.004]
[386,"ENSG00000100401.19","RANGAP1","chr22","-",41256710,41256824,41257947,41258106,41256190,41256290,41264663,41264843,386,"5,7",633628,"26,19",589654,298,263,{"v":1.96476489481E-5,"d":"1.96E-05"},0.000123210444938559,"0.007,0.01","0.037,0.025",-0.022]
[387,"ENSG00000100401.19","RANGAP1","chr22","-",41257947,41258106,41264663,41264843,41256710,41256824,41268096,41268156,387,687689,952891,664697,799821,298,298,0.297232618578,0.480884195480204,"0.419,0.436","0.454,0.459",-0.029]
[388,"ENSG00000100401.19","RANGAP1","chr22","-",41261445,41261580,41264663,41264843,41257947,41258106,41268096,41268156,388,692694,11281178,674713,910998,298,284,0.0875568652107,0.189305157066006,"0.369,0.36","0.414,0.405",-0.045]
[389,"ENSG00000100395.14","L3MBTL2","chr22","+",41213850,41214026,41216138,41216262,41209695,41209933,41219418,41219536,389,"1,0","0,0","20,7","3,6",298,273,1,1,"1.0,NA","0.859,0.517",0.312]
[390,"ENSG00000100395.14","L3MBTL2","chr22","+",41213892,41214026,41216138,41216262,41209695,41209933,41219418,41219536,390,188163,"0,0",113116,"3,6",283,273,0.0129779370573,0.0390938822550574,"1.0,1.0","0.973,0.949",0.039]
[391,"ENSG00000100395.14","L3MBTL2","chr22","+",41217122,41217202,41219418,41219536,41216138,41216262,41220733,41220868,391,98115,206195,"88,79",120147,229,267,0.331018379109,0.51884561982561,"0.357,0.407","0.461,0.385",-0.041]
[392,"ENSG00000100395.14","L3MBTL2","chr22","+",41224019,41224251,41224724,41224801,41221198,41221287,41224966,41225071,392,233161,"90,56",139127,79111,298,226,0.000733225305526,3.24563423756179E-3,"0.663,0.686","0.572,0.465",0.156]
[393,"ENSG00000196236.12","XPNPEP3","chr22","+",40868998,40869115,40881769,40882177,40857097,40857245,40886312,40886515,393,"63,94",142124,118128,144181,266,298,0.202519615053,0.362207532486337,"0.332,0.459","0.479,0.442",-0.065]
[394,"ENSG00000196236.12","XPNPEP3","chr22","+",40870047,40870139,40881769,40882177,40868998,40869115,40907586,40907649,394,"8,10","74,71","4,3","131,95",241,298,0.00104034423232,0.00443389502200267,"0.118,0.148","0.036,0.038",0.096]
[395,"ENSG00000196236.12","XPNPEP3","chr22","+",40870047,40870139,40886312,40886515,40868998,40869115,40907586,40907649,395,"8,10","84,86","4,3","88,70",241,298,0.0322071662996,0.0840393472983059,"0.105,0.126","0.053,0.05",0.064]
[396,"ENSG00000196236.12","XPNPEP3","chr22","+",40881769,40882177,40886312,40886515,40868998,40869115,40907586,40907649,396,"74,71","84,86","131,95","88,70",298,298,0.00459842698459,0.0161465941423273,"0.468,0.452","0.598,0.576",-0.127]
[397,"ENSG00000196236.12","XPNPEP3","chr22","+",40886312,40886515,40907586,40907649,40881769,40882177,40909121,40909235,397,142126,"49,32",144178,"29,26",298,212,0.00834470110818,0.0269029817369174,"0.673,0.737","0.779,0.83",-0.099]
[398,"ENSG00000196236.12","XPNPEP3","chr22","+",40907586,40907649,40909121,40909235,40886312,40886515,40914238,40914324,398,"40,48","50,47","32,27","65,46",212,263,0.0241722197836,0.0663319011135452,"0.498,0.559","0.379,0.421",0.128]
[399,"ENSG00000100372.14","SLC25A17","chr22","-",40779757,40779894,40784512,40784604,40779008,40779125,40792524,40792676,399,"6,8","6,5","1,3","0,2",241,286,0.0911822884468,0.195643128257367,"0.543,0.655","1.0,0.64",-0.221]
[400,"ENSG00000100372.14","SLC25A17","chr22","-",40779757,40779894,40817202,40817377,40779008,40779125,40819194,40819338,400,"4,11","4,2","10,4","0,4",298,286,0.489685147811,0.677884023545398,"0.49,0.841","1.0,0.49",-0.08]
[401,"ENSG00000100372.14","SLC25A17","chr22","-",40784512,40784604,40792524,40792676,40779008,40779125,40794513,40794580,401,952952,"8,10",445494,"1,2",298,241,0.845993507746,0.963291345742911,"0.99,0.987","0.997,0.995",-0.008]
[402,"ENSG00000100372.14","SLC25A17","chr22","-",40792524,40792676,40794513,40794580,40779008,40779125,40799022,40799083,402,149151,487482,"91,94",255294,216,298,0.570305158851,0.751993511285134,"0.297,0.302","0.33,0.306",-0.019]
[403,"ENSG00000100372.14","SLC25A17","chr22","-",40792524,40792676,40797283,40797336,40779008,40779125,40799022,40799083,403,"14,3",487482,"0,0",255294,202,298,0.0105417254633,0.0327564692898475,"0.041,0.009","0.0,0.0",0.025]
[404,"ENSG00000100372.14","SLC25A17","chr22","-",40794513,40794580,40797283,40797336,40779008,40779125,40799022,40799083,404,"14,3",149151,"0,0","91,94",202,216,0.000128954286115,0.000679520134783755,"0.091,0.021","0.0,0.0",0.056]
[405,"ENSG00000284431.1","AL022238.4","chr22","+",40364879,40365056,40366435,40366498,40364275,40364365,40400695,40400813,405,18951769,"77,59",599648,"49,72",298,212,{"v":7.18144510525e-09,"d":"7.18E-09"},{"v":7.55085101325196e-08,"d":"7.55E-08"},"0.946,0.955","0.897,0.865",0.069]
[406,"ENSG00000100354.20","TNRC6B","chr22","+",40246014,40246102,40251178,40251200,40156114,40156182,40261831,40262173,406,"9,9","18,17","15,13","29,39",237,171,0.629026047745,0.80130026520143,"0.265,0.276","0.272,0.194",0.038]
[407,"ENSG00000100354.20","TNRC6B","chr22","+",40246014,40246102,40251178,40251200,40177924,40178140,40261831,40262173,407,"44,21","18,17","34,23","29,39",237,171,0.0380858850368,0.0965750762771537,"0.638,0.471","0.458,0.298",0.176]
[408,"ENSG00000100354.20","TNRC6B","chr22","+",40264687,40267036,40270121,40270280,40261831,40262173,40273424,40273600,408,"70,91","25,24",129111,"40,28",298,298,0.776148141876,0.914642437953926,"0.737,0.791","0.763,0.799",-0.017]
[409,"ENSG00000100354.20","TNRC6B","chr22","+",40264687,40267036,40270121,40270280,40261831,40262173,40277076,40277151,409,"40,56","0,0","72,62","7,0",298,298,0.0222316995689,0.0617368454643224,"1.0,1.0","0.911,1.0",0.044]
[410,"ENSG00000100354.20","TNRC6B","chr22","+",40264687,40267036,40273424,40273600,40261831,40262173,40277076,40277151,410,"40,56","96,76","72,62","97,88",298,298,0.25930733617,0.435381664986322,"0.294,0.424","0.426,0.413",-0.06]
[411,"ENSG00000100354.20","TNRC6B","chr22","+",40270121,40270280,40273424,40273600,40261831,40262173,40277076,40277151,411,"0,0","96,76","7,0","97,88",298,298,0.0564881222106,0.132889919165529,"0.0,0.0","0.067,0.0",-0.034]
[412,"ENSG00000100354.20","TNRC6B","chr22","+",40270121,40270280,40273424,40273600,40264687,40267036,40277076,40277151,412,"34,28",122112,"49,24",151137,298,298,0.816111076285,0.941624718755657,"0.218,0.2","0.245,0.149",0.012]
[413,"ENSG00000100354.20","TNRC6B","chr22","+",40273424,40273600,40277076,40277151,40264687,40267036,40277998,40278044,413,"31,37","85,74","79,71","58,64",298,224,{"v":4.29443641203e-07,"d":"4.29E-07"},{"v":3.5241669737729e-06,"d":"3.52E-06"},"0.215,0.273","0.506,0.455",-0.237]
[414,"ENSG00000100354.20","TNRC6B","chr22","+",40273424,40273600,40277076,40277151,40270121,40270280,40277998,40278044,414,"26,25","85,73","58,50","61,64",298,224,{"v":1.11441030421e-05,"d":"1.11E-05"},{"v":7.30232870378958e-05,"d":"7.30E-05"},"0.187,0.205","0.417,0.37",-0.197]
[415,"ENSG00000100351.16","GRAP2","chr22","+",39947092,39947184,39955818,39955910,39901081,39901330,39960054,39960174,415,111116,"115,79","30,29","29,30",241,241,0.500872601874,0.68870365898702,"0.491,0.595","0.508,0.492",0.043]
[416,"ENSG00000100351.16","GRAP2","chr22","+",39947092,39947184,39960054,39960174,39901081,39901330,39965989,39966158,416,107109,196152,"28,26","24,22",241,269,0.00811537445484,0.0262933451515212,"0.379,0.445","0.566,0.569",-0.155]
[417,"ENSG00000100351.16","GRAP2","chr22","+",39955818,39955910,39960054,39960174,39946816,39947184,39965989,39966158,417,136150,195158,"40,42","30,25",241,269,0.00505910033621,0.0175340005328246,"0.438,0.514","0.598,0.652",-0.149]
[418,"ENSG00000128394.16","APOBEC3F","chr22","+",39045427,39045542,39049424,39049581,39044940,39045220,39052073,39052353,418,"64,58","65,50","6,2","3,6",264,298,0.765173409135,0.906763461661952,"0.526,0.567","0.693,0.273",0.064]
[419,"ENSG00000100226.15","GTPBP1","chr22","+",38726257,38726440,38727212,38727348,38726005,38726150,38727982,38728161,419,354458,453527,426390,187235,298,285,{"v":7.50970396979e-11,"d":"7.51E-11"},{"v":1.00797812722348E-9,"d":"1.01E-09"},"0.428,0.454","0.685,0.613",-0.208]
[420,"ENSG00000100211.10","CBY1","chr22","+",38656955,38657143,38665545,38665685,38656675,38656750,38668016,38668132,420,"6,8","14,11","9,4","3,4",298,289,0.0458216314476,0.111958051000013,"0.294,0.414","0.744,0.492",-0.264]
[422,"ENSG00000100201.20","DDX17","chr22","-",38487872,38488115,38493709,38493771,38483439,38486440,38494020,38494131,422,396374,335274,594532,422485,211,298,0.864887300286,0.976245993676586,"0.625,0.658","0.665,0.608",0.005]
[423,"ENSG00000100201.20","DDX17","chr22","-",38487878,38488115,38493709,38493771,38485877,38486440,38494020,38494131,423,396374,12891234,594532,17731779,211,298,0.744455381272,0.890690519797687,"0.303,0.3","0.321,0.297",-0.008]
[424,"ENSG00000100201.20","DDX17","chr22","-",38494885,38495046,38495795,38495937,38494629,38494802,38498084,38498150,424,13221190,29372717,19461849,33203035,291,298,0.00466521772726,0.0163402614362907,"0.316,0.31","0.375,0.384",-0.067]
[425,"ENSG00000100201.20","DDX17","chr22","-",38495795,38495937,38498084,38498150,38494885,38495046,38498439,38498573,425,19261886,22612194,23602282,29092597,215,291,0.899883877628,0.998559284231249,"0.536,0.538","0.523,0.543",0.004]
[426,"ENSG00000100201.20","DDX17","chr22","-",38498084,38498150,38498439,38498573,38495795,38495937,38499399,38499499,426,20282032,840805,25792681,12371120,283,215,0.351387987256,0.541221324763851,"0.647,0.657","0.613,0.645",0.023]
[427,"ENSG00000100116.16","GCAT","chr22","+",37809948,37810157,37813462,37813609,37807904,37808163,37815125,37815280,427,"69,57",197207,"15,27","66,66",298,296,0.977475260397,1,"0.258,0.215","0.184,0.289",0]
[428,"ENSG00000100116.16","GCAT","chr22","+",37810026,37810157,37813462,37813609,37807911,37808163,37815125,37815280,428,206214,197207,"30,26","66,66",280,296,{"v":3.86703966604e-06,"d":"3.87E-06"},{"v":2.7314842582915e-05,"d":"2.73E-05"},"0.525,0.522","0.325,0.294",0.214]
[429,"ENSG00000285304.1","Z83844.3","chr22","+",37643097,37643174,37643643,37643788,37642894,37643006,37644636,37644705,429,159159,348337,121131,275265,226,294,0.977667824239,1,"0.373,0.38","0.364,0.391",-1E-3]
[430,"ENSG00000285304.1","Z83844.3","chr22","+",37643643,37643788,37644636,37644705,37643097,37643174,37644869,37644960,430,386348,230196,300277,161145,294,218,0.512140399603,0.699871222398723,"0.554,0.568","0.58,0.586",-0.022]
[431,"ENSG00000285304.1","Z83844.3","chr22","+",37645364,37645510,37646817,37646929,37644869,37644960,37647266,37647348,431,299247,214192,247213,146159,295,261,0.411696975057,0.603318074757164,"0.553,0.532","0.599,0.542",-0.028]
[432,"ENSG00000285304.1","Z83844.3","chr22","+",37648318,37648435,37650151,37650249,37647440,37647521,37650541,37650725,432,302300,287248,197233,198263,266,247,0.166481569494,0.312789767354501,"0.494,0.529","0.48,0.451",0.046]
[433,"ENSG00000128340.14","RAC2","chr22","-",37226670,37226803,37231230,37231390,37225260,37226039,37231931,37231994,433,14431444,12611307,10761085,10471053,298,282,0.413992182545,0.605598330052318,"0.52,0.511","0.493,0.494",0.022]
[434,"ENSG00000128340.14","RAC2","chr22","-",37231230,37231390,37231931,37231994,37226670,37226803,37232800,37232918,434,756736,9631114,529530,947964,212,298,0.0198808574519,0.0563307674762599,"0.525,0.482","0.44,0.436",0.066]
[435,"ENSG00000128340.14","RAC2","chr22","-",37231931,37231994,37232800,37232918,37231230,37231390,37241586,37241658,435,729841,677692,591669,596612,267,212,0.409479352884,0.601188681387258,"0.461,0.491","0.441,0.465",0.023]
[436,"ENSG00000100365.14","NCF4","chr22","+",36864918,36865072,36867391,36867462,36860987,36861203,36870414,36870542,436,"77,60",11691265,268321,12331161,298,220,0,0,"0.046,0.034","0.138,0.17",-0.114]
[437,"ENSG00000100336.17","APOL4","chr22","-",36199329,36199376,36201699,36201796,36195310,36195437,36201992,36202055,437,"0,1",104103,"0,0","11,7",246,196,1,1,"0.0,0.008","0.0,0.0",0.004]
[438,"ENSG00000100336.17","APOL4","chr22","-",36199329,36199376,36201699,36201888,36195310,36195437,36201992,36202055,438,"0,1",104103,"0,0","11,7",298,196,1,1,"0.0,0.006","0.0,0.0",0.003]
[439,"ENSG00000100336.17","APOL4","chr22","-",36199329,36199376,36201699,36202055,36195310,36195437,36204627,36204806,439,"0,1",104103,"0,0","11,7",298,196,1,1,"0.0,0.006","0.0,0.0",0.003]
[442,"ENSG00000100320.22","RBFOX2","chr22","-",35768256,35768349,35778024,35778078,35765422,35765483,35781599,35781743,442,"19,27","53,48","32,58","39,44",203,242,0.00275004614482,0.0103467493013999,"0.299,0.401","0.494,0.611",-0.203]
[443,"ENSG00000100281.13","HMGXB4","chr22","+",35288237,35288407,35292991,35293114,35287346,35287452,35293606,35295764,443,398366,153163,751495,305309,298,272,0.207880951281,0.369502182923248,"0.704,0.672","0.692,0.594",0.045]
[444,"ENSG00000100220.11","RTCB","chr22","-",32406661,32406761,32408754,32408833,32401561,32401903,32412063,32412241,444,347362,797791,327363,588630,228,249,0.0471072397641,0.114538747999086,"0.322,0.333","0.378,0.386",-0.054]
[445,"ENSG00000285404.1","Z82190.2","chr22","+",31758545,31758633,31760655,31760702,31754898,31754979,31764974,31765060,445,"48,46","53,47","65,52","64,59",237,196,0.961727492143,1,"0.428,0.447","0.456,0.422",-2E-3]
[446,"ENSG00000285404.1","Z82190.2","chr22","+",31797599,31797703,31798581,31798656,31792744,31792817,31802703,31802838,446,"57,46","55,55","46,42","53,28",253,224,0.508956641494,0.696772564203626,"0.479,0.425","0.435,0.57",-0.05]
[447,"ENSG00000100150.17","DEPDC5","chr22","+",31754861,31754979,31758545,31758633,31753866,31753996,31760655,31760702,447,"12,0","83,63","9,5",94108,267,237,0.835644112794,0.955854124702149,"0.114,0.0","0.078,0.039",-1E-3]
[448,"ENSG00000100150.17","DEPDC5","chr22","+",31758526,31758633,31760655,31760702,31754861,31754979,31764974,31765060,448,"1,0","53,47","35,18","64,59",256,196,{"v":2.52309284576e-12,"d":"2.52E-12"},{"v":3.97276616337641e-11,"d":"3.97E-11"},"0.014,0.0","0.295,0.189",-0.235]
[449,"ENSG00000100150.17","DEPDC5","chr22","+",31778098,31778168,31783906,31783985,31768813,31768863,31784813,31784875,449,"59,63","44,22","63,95","20,24",219,228,0.0339449353894,0.0877281749786552,"0.583,0.749","0.766,0.805",-0.12]
[450,"ENSG00000100150.17","DEPDC5","chr22","+",31806121,31806191,31809610,31809647,31804841,31804915,31810520,31810641,450,"88,65","31,32","53,40","29,24",219,186,0.202876953626,0.362673424379234,"0.707,0.633","0.608,0.586",0.073]
[451,"ENSG00000100150.17","DEPDC5","chr22","+",31821501,31821637,31822692,31822790,31819021,31819225,31833914,31833980,451,"82,46","34,38","8,6","6,3",285,247,0.902508834227,1,"0.676,0.512","0.536,0.634",0.009]
[452,"ENSG00000100150.17","DEPDC5","chr22","+",31821501,31821637,31831063,31831225,31819021,31819225,31833914,31833980,452,"82,46","1,2","8,6","0,0",285,298,0.46623856293,0.656591304949807,"0.988,0.96","1.0,1.0",-0.026]
[453,"ENSG00000100150.17","DEPDC5","chr22","+",31822692,31822790,31831063,31831225,31819021,31819225,31833914,31833980,453,"34,38","1,2","6,3","0,0",247,298,0.434922836322,0.626588946481086,"0.976,0.958","1.0,1.0",-0.033]
[454,"ENSG00000100150.17","DEPDC5","chr22","+",31822692,31822790,31833914,31833980,31821501,31821637,31837093,31837155,454,"56,60","4,14","7,2","0,2",247,215,0.319052346688,0.505912997722842,"0.924,0.789","1.0,0.465",0.124]
[455,"ENSG00000100150.17","DEPDC5","chr22","+",31833914,31833980,31836971,31837155,31819021,31819225,31838684,31838845,455,"18,15","87,72","27,21","47,70",215,298,0.0238730921137,0.0656473512058163,"0.223,0.224","0.443,0.294",-0.145]
[456,"ENSG00000100150.17","DEPDC5","chr22","+",31833914,31833980,31838684,31838845,31819021,31819225,31843094,31843212,456,"18,16","73,86","25,21","65,53",215,298,0.0263929738403,0.0711230186156993,"0.255,0.205","0.348,0.355",-0.121]
[457,"ENSG00000100150.17","DEPDC5","chr22","+",31833914,31833980,31837093,31837155,31822692,31822790,31838684,31838845,457,"28,43","36,36","2,4","18,33",215,211,{"v":6.56882979122E-8,"d":"6.57E-08"},{"v":6.0589095475748e-07,"d":"6.06E-07"},"0.433,0.54","0.098,0.106",0.385]
[458,"ENSG00000100150.17","DEPDC5","chr22","+",31836971,31837155,31838684,31838845,31833914,31833980,31843094,31843212,458,"60,58","73,86","65,71","64,53",298,298,0.0262395199276,0.0707944012071619,"0.451,0.403","0.504,0.573",-0.111]
[459,"ENSG00000100150.17","DEPDC5","chr22","+",31836998,31837155,31838684,31838845,31833865,31833980,31843094,31843212,459,"30,36","73,86","2,2","64,53",298,298,{"v":4.73719952154e-11,"d":"4.74E-11"},{"v":6.51010006418851e-10,"d":"6.51E-10"},"0.291,0.295","0.03,0.036",0.26]
[460,"ENSG00000100150.17","DEPDC5","chr22","+",31837093,31837155,31838684,31838845,31833914,31833980,31843094,31843212,460,"0,5","73,86","0,1","64,53",211,298,0.112919957212,0.23153846674543,"0.0,0.076","0.0,0.026",0.025]
[461,"ENSG00000100150.17","DEPDC5","chr22","+",31846833,31846967,31857444,31857553,31845017,31845237,31870589,31870744,461,"50,85",90102,"44,43","55,45",283,258,0.312197498878,0.498654746090205,"0.336,0.432","0.422,0.466",-0.06]
[462,"ENSG00000100150.17","DEPDC5","chr22","+",31876086,31876265,31879524,31879752,31874272,31874405,31893581,31893751,462,"4,3","62,75","1,1","23,37",298,298,0.199456768767,0.357916570530861,"0.061,0.038","0.042,0.026",0.015]
[463,"ENSG00000100150.17","DEPDC5","chr22","+",31876156,31876265,31879524,31879752,31874272,31874405,31893581,31893751,463,"83,69","62,75","8,13","23,37",258,298,{"v":6.21578910716e-05,"d":"6.22E-05"},3.51226910900473E-4,"0.607,0.515","0.287,0.289",0.273]
[464,"ENSG00000100150.17","DEPDC5","chr22","+",31879524,31879752,31893581,31893751,31870589,31870744,31897481,31897653,464,"2,3","65,84","2,1","10,7",298,298,0.42951101927,0.621479636136786,"0.03,0.034","0.167,0.125",-0.114]
[465,"ENSG00000100150.17","DEPDC5","chr22","+",31879524,31879752,31893581,31893751,31875738,31876265,31897481,31897653,465,"32,66","67,88","6,14","8,7",298,298,0.110614812416,0.227809736038048,"0.323,0.429","0.429,0.667",-0.172]
[466,"ENSG00000100150.17","DEPDC5","chr22","+",31893581,31893751,31897481,31897653,31879524,31879752,31901741,31901802,466,"62,68","73,57","19,31","19,12",298,298,0.189765503685,0.34501460985898,"0.459,0.544","0.5,0.721",-0.109]
[467,"ENSG00000100150.17","DEPDC5","chr22","+",31897481,31897653,31901741,31901802,31893581,31893751,31905983,31906066,467,"65,84","49,49","8,7","15,14",298,210,0.00119850246497,0.00502878653322333,"0.483,0.547","0.273,0.261",0.248]
[468,"ENSG00000138942.15","RNF185","chr22","+",31192683,31192702,31201497,31201615,31160182,31160303,31204488,31204571,468,"0,0","85,72","4,1",101101,168,267,0.225582915825,0.392126143870642,"0.0,0.0","0.059,0.015",-0.037]
[469,"ENSG00000138942.15","RNF185","chr22","+",31192683,31192702,31201497,31201615,31187046,31187270,31204488,31204966,469,"11,8","84,72","8,7","101,97",168,267,0.197392983552,0.35506636108923,"0.172,0.15","0.112,0.103",0.053]
[470,"ENSG00000138942.15","RNF185","chr22","+",31195468,31195581,31196935,31197157,31192683,31192702,31201497,31201615,470,152150,"2,5",163126,"9,6",262,298,0.0557687882818,0.131541980254436,"0.989,0.972","0.954,0.96",0.023]
[471,"ENSG00000138942.15","RNF185","chr22","+",31196935,31196990,31201497,31201615,31195468,31195581,31204488,31204966,471,150134,"83,76","86,95",113108,204,267,{"v":5.19665158849E-6,"d":"5.20E-06"},{"v":3.59839260518168e-05,"d":"3.60E-05"},"0.703,0.698","0.499,0.535",0.183]
[472,"ENSG00000183963.18","SMTN","chr22","+",31080449,31080754,31083178,31083309,31064117,31064187,31087964,31088024,472,"68,40",128114,"11,11","91,69",298,280,{"v":6.17335174324E-6,"d":"6.17E-06"},{"v":4.21992821170853e-05,"d":"4.22E-05"},"0.333,0.248","0.102,0.13",0.174]
[473,"ENSG00000248751.6","AC004997.1","chr22","-",30286015,30286098,30286262,30286376,30285831,30285926,30286824,30286948,473,"49,45","28,37","8,21","15,15",263,232,0.25715816801,0.43291278017657,"0.607,0.518","0.32,0.553",0.126]
[474,"ENSG00000248751.6","AC004997.1","chr22","-",30286015,30286142,30286262,30286376,30285831,30285926,30286824,30286948,474,"49,45","28,35","8,21","14,13",263,276,0.369741479077,0.560461532306625,"0.647,0.574","0.375,0.629",0.109]
[475,"ENSG00000248751.6","AC004997.1","chr22","-",30288705,30288776,30292772,30292851,30287372,30287560,30293650,30293805,475,"24,7","18,22","4,14","2,8",228,220,0.0774443100129,0.171691781122826,"0.563,0.235","0.659,0.628",-0.244]
[476,"ENSG00000100330.15","MTMR3","chr22","+",30016527,30016698,30019479,30020884,30013355,30013541,30022028,30022139,476,168194,132166,317325,"55,67",298,298,0,0,"0.56,0.539","0.852,0.829",-0.291]
[477,"ENSG00000100330.15","MTMR3","chr22","+",30016527,30016698,30019479,30020884,30013355,30013541,30022608,30022697,477,168194,"39,33",318323,206187,298,298,{"v":2.20984341937e-11,"d":"2.21E-11"},{"v":3.16059654932046e-10,"d":"3.16E-10"},"0.812,0.855","0.607,0.633",0.214]
[478,"ENSG00000100330.15","MTMR3","chr22","+",30019479,30020884,30022028,30022139,30016527,30016698,30022608,30022697,478,"40,33",95101,264217,"52,92",298,260,0,0,"0.269,0.222","0.816,0.673",-0.499]
[479,"ENSG00000100319.12","ZMAT5","chr22","-",29738329,29738441,29740649,29740730,29730955,29731354,29742417,29742480,479,462493,442444,435410,439517,230,261,0.102641921008,0.215116250641614,"0.543,0.558","0.529,0.474",0.049]
[480,"ENSG00000186575.17","NF2","chr22","+",29639089,29639212,29642201,29642285,29636750,29636876,29654656,29654725,480,"110,79","90,64","82,57","84,68",272,233,0.112679726692,0.231109153723646,"0.511,0.514","0.455,0.418",0.076]
[481,"ENSG00000100296.13","THOC5","chr22","-",29525837,29525946,29529161,29529239,29520997,29521099,29536623,29536738,481,"3,0",412426,"4,1",228258,227,258,1,1,"0.008,0.0","0.02,0.004",-0.008]
[482,"ENSG00000100296.13","THOC5","chr22","-",29539329,29539476,29542858,29542956,29535793,29536738,29543428,29543542,482,260229,437485,155140,306296,247,296,0.550714093405,0.735273484447648,"0.416,0.361","0.378,0.362",0.018]
[483,"ENSG00000100280.16","AP1B1","chr22","-",29363000,29363106,29367206,29367267,29359672,29359959,29388423,29388529,483,"0,3","10,23","0,7","65,59",210,255,0.732015301245,0.881337697728787,"0.0,0.137","0.0,0.126",0.006]
[484,"ENSG00000100280.16","AP1B1","chr22","-",29363000,29363106,29367206,29367270,29359823,29359959,29388423,29388583,484,322350,"10,23",367325,"65,59",213,255,{"v":6.13657902271e-10,"d":"6.14E-10"},{"v":7.37735655758539e-09,"d":"7.38E-09"},"0.975,0.948","0.871,0.868",0.092]
[485,"ENSG00000100209.9","HSCB","chr22","+",28744614,28744704,28745863,28746008,28743881,28743978,28751240,28751288,485,"49,80",137121,"51,52","94,97",239,294,0.704436651937,0.860836637026782,"0.306,0.449","0.4,0.397",-0.021]
[486,"ENSG00000100209.9","HSCB","chr22","+",28744614,28744709,28745863,28746008,28743881,28743978,28751240,28751288,486,"56,80",137121,"51,54","94,97",244,294,0.83020613352,0.952069699079307,"0.33,0.443","0.395,0.401",-0.012]
[487,"ENSG00000100209.9","HSCB","chr22","+",28745863,28746008,28751240,28751288,28744614,28744704,28757077,28757210,487,"71,63","28,19","47,42","21,11",294,197,0.981108231507,1,"0.63,0.69","0.6,0.719",0]
[488,"ENSG00000183765.21","CHEK2","chr22","-",28719394,28719485,28724885,28724923,28711908,28712017,28725242,28725367,488,"9,9",282209,"0,0",237245,187,240,{"v":6.26595706971e-05,"d":"6.27E-05"},0.000353743189445512,"0.039,0.052","0.0,0.0",0.045]
[489,"ENSG00000183765.21","CHEK2","chr22","-",28719394,28719485,28724976,28725124,28711908,28712017,28725242,28725367,489,493393,282209,231234,237245,297,240,{"v":1.75742869002e-06,"d":"1.76E-06"},{"v":1.31319139461454E-5,"d":"1.31E-05"},"0.586,0.603","0.441,0.436",0.156]
[490,"ENSG00000183765.21","CHEK2","chr22","-",28719394,28719485,28725242,28725367,28711908,28712017,28734402,28734721,490,407318,282209,315348,173162,274,240,0.0297537041793,0.0786512916711402,"0.558,0.571","0.615,0.653",-0.07]
[491,"ENSG00000183765.21","CHEK2","chr22","-",28724564,28724923,28724976,28725124,28719394,28719485,28725242,28725367,491,13321159,"8,8",566527,"0,0",297,298,1,1,"0.994,0.993","1.0,1.0",-0.006]
[492,"ENSG00000183765.21","CHEK2","chr22","-",28724885,28724923,28724976,28725124,28711908,28712017,28725242,28725367,492,493393,"9,9",231234,"0,0",297,187,0.002317758639,0.00893118141994357,"0.972,0.965","1.0,1.0",-0.032]
[493,"ENSG00000183765.21","CHEK2","chr22","-",28724885,28724923,28724976,28725124,28719394,28719485,28725242,28725367,493,13321159,"12,13",566527,"0,0",297,187,0.132444424079,0.262147089907597,"0.986,0.982","1.0,1.0",-0.016]
[494,"ENSG00000123130.16","ACOT9","chrX","-",23704693,23704844,23704992,23705080,23702252,23703982,23705508,23705594,494,"92,75",216191,"68,87",148172,237,298,0.323951895513,0.510834103465618,"0.349,0.331","0.366,0.389",-0.038]
[495,"ENSG00000128294.15","TPST2","chr22","-",26536287,26536486,26540788,26541718,26532694,26532745,26544603,26544675,495,121106,309287,175156,286313,298,298,0.00927988629866,0.0293799866485263,"0.281,0.27","0.38,0.333",-0.081]
[496,"ENSG00000100104.13","SRRD","chr22","+",26488389,26488488,26490043,26490198,26487981,26488288,26491024,26491070,496,178187,232187,278230,84115,248,298,{"v":1.30049526703E-10,"d":"1.30E-10"},{"v":1.69987365648034e-09,"d":"1.70E-09"},"0.48,0.546","0.799,0.706",-0.239]
[497,"ENSG00000100099.20","HPS4","chr22","-",26463916,26464826,26476992,26477136,26453111,26453404,26479264,26479488,497,331237,"22,12",223294,"54,61",293,298,{"v":5.72000224963e-10,"d":"5.72E-10"},{"v":6.91354118057753e-09,"d":"6.91E-09"},"0.939,0.953","0.808,0.831",0.126]
[498,"ENSG00000100099.20","HPS4","chr22","-",26463916,26464826,26468550,26468623,26458444,26458577,26472301,26472418,498,"0,0",415475,"0,3",644645,222,298,1,1,"0.0,0.0","0.0,0.006",-0.003]
[499,"ENSG00000100099.20","HPS4","chr22","-",26463916,26464826,26476992,26477136,26458444,26458577,26479264,26479355,499,331237,415475,223293,644644,293,298,0.00423384037602,0.0150403414085048,"0.448,0.337","0.26,0.316",0.104]
[500,"ENSG00000100099.20","HPS4","chr22","-",26465454,26465551,26466050,26466104,26463916,26464826,26466225,26466262,500,"11,10",412510,"19,15",524562,203,246,0.250595334747,0.424603793463199,"0.031,0.023","0.042,0.031",-0.01]
[501,"ENSG00000100099.20","HPS4","chr22","-",26465454,26465551,26466225,26466262,26463916,26464826,26468550,26468623,501,"31,48",199207,"46,40",282330,186,246,0.106424161784,0.221170354740928,"0.171,0.235","0.177,0.138",0.046]
[502,"ENSG00000100099.20","HPS4","chr22","-",26465454,26465551,26466225,26468623,26463916,26464826,26470718,26470813,502,240310,199207,233258,282335,298,246,{"v":8.23969239101e-05,"d":"8.24E-05"},0.000451885888048825,"0.499,0.553","0.405,0.389",0.129]
[503,"ENSG00000100099.20","HPS4","chr22","-",26466225,26466262,26468550,26468623,26465454,26465551,26470718,26470813,503,232297,"66,76",221246,"82,64",222,186,0.379691270233,0.570768926932847,"0.747,0.766","0.693,0.763",0.028]
[504,"ENSG00000100099.20","HPS4","chr22","-",26466225,26466262,26470718,26470813,26465454,26465551,26472301,26472418,504,239256,"64,76",319317,"65,42",244,186,2.42132955601E-3,0.00925567434399263,"0.74,0.72","0.789,0.852",-0.091]
[505,"ENSG00000100099.20","HPS4","chr22","-",26466225,26466262,26470718,26470922,26465454,26465551,26472301,26472418,505,"16,13","64,76","61,39","65,42",298,186,{"v":1.75400038938E-9,"d":"1.75E-09"},{"v":1.99295313394533e-08,"d":"1.99E-08"},"0.135,0.096","0.369,0.367",-0.253]
[506,"ENSG00000100099.20","HPS4","chr22","-",26466225,26468623,26470718,26470813,26465454,26465551,26472301,26472418,506,239256,"68,79",319317,"67,43",244,298,0.00143219449151,0.00587654821580317,"0.811,0.798","0.853,0.9",-0.072]
[507,"ENSG00000100099.20","HPS4","chr22","-",26466225,26468623,26470718,26470922,26465454,26465551,26472301,26472418,507,"16,13","68,79","61,39","67,43",298,298,{"v":8.65280402884e-10,"d":"8.65E-10"},{"v":1.0200412052676e-08,"d":"1.02E-08"},"0.19,0.141","0.477,0.476",-0.311]
[508,"ENSG00000100099.20","HPS4","chr22","-",26468550,26468623,26470718,26470813,26465454,26466262,26472301,26472418,508,241256,133172,343340,129140,244,222,0.00203960200413,0.0079950832921837,"0.622,0.575","0.708,0.688",-0.099]
[509,"ENSG00000100099.20","HPS4","chr22","-",26468550,26468623,26470718,26470922,26466225,26466262,26472301,26472418,509,"18,13",133172,"76,53",129140,298,222,{"v":1.82481807443e-11,"d":"1.82E-11"},{"v":2.63000880784911e-10,"d":"2.63E-10"},"0.092,0.053","0.305,0.22",-0.19]
[510,"ENSG00000100099.20","HPS4","chr22","-",26472831,26472939,26476992,26477136,26472301,26472418,26479264,26479355,510,331237,296322,222294,392407,293,257,0.0269402557663,0.0723203913565516,"0.495,0.392","0.332,0.388",0.084]
[511,"ENSG00000100099.20","HPS4","chr22","-",26476992,26477136,26481721,26482240,26472831,26472939,26483764,26483783,511,"27,22",316332,"63,87",461463,298,293,{"v":5.94299150587e-05,"d":"5.94E-05"},0.00033677951108548,"0.077,0.061","0.118,0.156",-0.068]
[515,"ENSG00000102024.17","PLS3","chrX","+",115640407,115640503,115643312,115643508,115636835,115636978,115645020,115645099,515,"62,37","50,37","30,15","66,39",245,298,{"v":6.94871604263e-05,"d":"6.95E-05"},3.87709711353001E-4,"0.601,0.549","0.356,0.319",0.237]
[516,"ENSG00000133454.15","MYO18B","chr22","+",25770871,25770984,25777582,25777781,25770026,25770176,25780055,25780198,516,"23,10","11,22","65,51","40,30",262,298,0.298535106832,0.48222755682302,"0.704,0.341","0.649,0.659",-0.132]
[517,"ENSG00000133454.15","MYO18B","chr22","+",25785427,25785491,25797952,25798097,25781733,25781834,25823504,25823678,517,"8,9","20,15","25,27","27,17",213,294,0.0195253422191,0.055463326715671,"0.356,0.453","0.561,0.687",-0.22]
[518,"ENSG00000133454.15","MYO18B","chr22","+",25847429,25847652,25851469,25851579,25846099,25846283,25868319,25868385,518,"28,23","9,14","28,25","10,25",298,259,0.44613620137,0.637592819525666,"0.73,0.588","0.709,0.465",0.072]
[519,"ENSG00000184117.11","NIPSNAP1","chr22","-",29564237,29564371,29569192,29569287,29561791,29561862,29570161,29570207,519,722607,"6,0",541521,"0,0",244,283,1,1,"0.993,1.0","1.0,1.0",-0.004]
[525,"ENSG00000258555.6","SPECC1L-ADORA2A","chr22","+",24302194,24302384,24313312,24313466,24276699,24276803,24321287,24322918,525,93109,310319,"42,34",364374,298,298,{"v":2.65679700462e-11,"d":"2.66E-11"},{"v":3.75680125215901e-10,"d":"3.76E-10"},"0.231,0.255","0.103,0.083",0.15]
[568,"ENSG00000099968.17","BCL2L13","chr22","+",17683213,17683321,17702242,17702386,17655661,17655832,17726676,17730855,568,348310,178195,165176,155134,257,293,0.00525468529013,0.018119449640169,"0.69,0.644","0.548,0.6",0.093]
[635,"ENSG00000185808.13","PIGP","chr21","-",37069551,37069624,37072144,37072310,37065373,37065712,37072433,37072537,635,"129,90",285270,"13,29",76139,298,222,0.000421913983179,1.97089091227628E-3,"0.252,0.199","0.113,0.135",0.102]
[676,"ENSG00000142207.6","URB1","chr21","-",32317675,32317917,32319216,32319414,32316465,32317065,32320530,32320640,676,512513,572624,370380,415494,298,298,0.763548803944,0.905434772842396,"0.472,0.451","0.471,0.435",0.009]
[721,"ENSG00000026036.22","RTEL1-TNFRSF6B","chr20","+",63680663,63680719,63685522,63685597,63679848,63679946,63685790,63685872,721,"76,56",139127,"39,41",72129,205,224,0.37269103942,0.563364519704571,"0.374,0.325","0.372,0.258",0.035]
[782,"ENSG00000124208.16","TMEM189-UBE2V1","chr20","-",50096671,50096820,50127974,50128187,50084128,50084254,50129545,50129690,782,281262,13011279,170214,766829,298,298,0.296755678598,0.480250888967045,"0.178,0.17","0.182,0.205",-0.02]
[806,"ENSG00000101040.19","ZMYND8","chr20","-",47238757,47239138,47249286,47249439,47236325,47236516,47262287,47262428,806,641732,"105,88",573598,391401,298,298,0,0,"0.859,0.893","0.594,0.599",0.279]
[863,"ENSG00000101040.19","ZMYND8","chr20","-",47310055,47310204,47347855,47347926,47298728,47298947,47356656,47356670,863,"10,11",616630,"19,16",885779,220,298,0.399084343078,0.590635364551415,"0.022,0.023","0.028,0.027",-0.005]
[886,"ENSG00000171100.14","MTM1","chrX","+",150598591,150598686,150614588,150614699,150596497,150596570,150619037,150619139,886,"72,90","108,86","2,7","15,7",244,260,0.17590861262,0.326005494635333,"0.415,0.527","0.124,0.516",0.151]
[938,"ENSG00000125991.19","ERGIC3","chr20","+",35548807,35548865,35555043,35555075,35548508,35548674,35556032,35556129,938,525461,191171,613549,253224,207,181,0.388892052203,0.580136470651255,"0.706,0.702","0.679,0.682",0.023]
[1015,"ENSG00000101294.17","HM13","chr20","+",31559610,31559647,31561633,31561740,31554746,31554829,31569119,31569567,1015,302351,"0,0",225274,"18,23",186,256,{"v":2.93300939092e-11,"d":"2.93E-11"},{"v":4.12143764881685E-10,"d":"4.12E-10"},"1.0,1.0","0.945,0.943",0.056]
[1036,"ENSG00000173418.11","NAA20","chr20","+",20025668,20025767,20026783,20026919,20017358,20017449,20032507,20032653,1036,"4,2",714628,"0,3",561547,248,285,1,1,"0.006,0.004","0.0,0.006",2E-3]
[1068,"ENSG00000125863.19","MKKS","chr20","-",10412529,10413931,10420527,10420758,10408627,10408803,10434107,10434222,1068,470451,281248,317460,130146,298,298,0.000401948433125,0.00188546541626004,"0.626,0.645","0.709,0.759",-0.099]
[1114,"ENSG00000130726.11","TRIM28","chr19","+",58549330,58549650,58549736,58549860,58548987,58549240,58549948,58550035,1114,50445370,70657439,42294493,53645910,298,273,0.461114044204,0.651948871081026,"0.395,0.398","0.419,0.411",-0.018]
[1188,"ENSG00000142541.16","RPL13A","chr19","+",49490126,49490297,49490474,49490576,49489849,49489922,49490778,49490864,1188,"0,1",3112231073,"9,17",4334842509,298,251,1,1,"0.0,0.0","0.0,0.0",0]
[1250,"ENSG00000105486.13","LIG1","chr19","-",48153871,48153967,48157013,48157140,48151231,48151336,48161371,48161507,1250,903835,110104,436427,"62,69",276,245,0.191934389695,0.347984652792459,"0.879,0.877","0.862,0.846",0.024]
[1259,"ENSG00000105402.7","NAPA","chr19","-",47492960,47493045,47493118,47493174,47492014,47492119,47493415,47493493,1259,456381,573614,347356,590471,205,234,0.645198953331,0.815169550292073,"0.476,0.415","0.402,0.463",0.013]
[1335,"ENSG00000167578.17","RAB4B","chr19","+",40780384,40780499,40783777,40783840,40780018,40780099,40783920,40784075,1335,112137,"42,56",116129,"4,11",264,212,{"v":2.04980477037e-12,"d":"2.05E-12"},{"v":3.26414340081102e-11,"d":"3.26E-11"},"0.682,0.663","0.959,0.904",-0.259]
[1353,"ENSG00000130402.11","ACTN4","chr19","+",38711275,38711361,38714468,38714561,38709394,38709476,38717085,38717316,1353,"42,64",10581264,"4,4",823816,235,242,{"v":3.51496609596e-13,"d":"3.51E-13"},{"v":5.9831646371307e-12,"d":"5.98E-12"},"0.039,0.05","0.005,0.005",0.04]
[1449,"ENSG00000105669.13","COPE","chr19","-",18906959,18907112,18910970,18911071,18905575,18905629,18912983,18913046,1449,758624,12561438,679682,9621067,250,298,0.0262141711173,0.070734503522831,"0.418,0.341","0.457,0.432",-0.065]
[1451,"ENSG00000105669.13","COPE","chr19","-",18906959,18907112,18910970,18911071,18905866,18905935,18912983,18913046,1451,670532,"6,19",531544,"4,16",250,298,0.682015321087,0.843332906802256,"0.993,0.971","0.994,0.976",-0.003]
[1522,"ENSG00000232907.7","DLGAP4-AS1","chr20","-",36508811,36508825,36510879,36511032,36507701,36508274,36571440,36571543,1522,"3,1","0,1","0,0","1,0",298,163,1,1,"1.0,0.354","0.0,NA",0.677]
[1584,"ENSG00000213339.8","QTRT1","chr19","+",10702115,10702254,10706709,10706825,10701949,10702018,10707301,10707380,1584,720637,"6,7",440471,"17,10",288,265,0.00086115565767,0.00374696097447467,"0.991,0.988","0.96,0.977",0.021]
[1603,"ENSG00000105364.13","MRPL4","chr19","+",10254588,10254640,10256707,10256825,10252396,10252463,10258221,10258328,1603,"0,0",16091514,"0,1",740784,201,267,1,1,"0.0,0.0","0.0,0.002",-1E-3]
[1668,"ENSG00000125648.14","SLC25A23","chr19","-",6452311,6452479,6453980,6454088,6444150,6444301,6454322,6454475,1668,"137,82",139103,"29,39","27,36",257,298,0.396309648773,0.587845359009805,"0.533,0.48","0.555,0.557",-0.05]
[1712,"ENSG00000071564.14","TCF3","chr19","-",1612206,1612433,1615284,1615520,1609289,1611849,1615685,1615821,1712,16451662,840803,711794,612709,298,298,{"v":3.10433075135E-7,"d":"3.10E-07"},{"v":2.60752178138628e-06,"d":"2.61E-06"},"0.662,0.674","0.537,0.528",0.136]
[1747,"ENSG00000172270.19","BSG","chr19","+",579499,579656,580378,580461,572577,572701,580645,580782,1747,31683168,13391429,32284148,17532013,298,232,0.123119638185,0.247638989381323,"0.648,0.633","0.589,0.616",0.038]
[1769,"ENSG00000176225.13","RTTN","chr18","-",70139598,70139716,70142287,70142387,70135183,70135280,70145611,70145783,1769,"14,25","22,19","22,11","11,5",249,267,0.0498804054442,0.120163271140316,"0.406,0.585","0.682,0.702",-0.196]
[1833,"ENSG00000078043.15","PIAS2","chr18","-",46844733,46844839,46846706,46846841,46844053,46844127,46855344,46855435,1833,168217,178124,"60,99","69,68",284,255,0.6519186131,0.820935903028857,"0.459,0.611","0.438,0.567",0.033]
[1904,"ENSG00000141446.10","ESCO1","chr18","-",21564202,21564317,21566145,21566206,21560858,21560990,21567979,21568094,1904,"97,87","84,68","62,60","69,79",210,264,0.0438440441692,0.108085828035988,"0.592,0.617","0.53,0.488",0.096]
[1924,"ENSG00000175354.19","PTPN2","chr18","-",12817155,12817265,12825809,12825944,12814324,12814355,12830942,12831041,1924,209214,185179,171178,100118,284,259,0.0313624988824,0.0821980622172688,"0.507,0.522","0.609,0.579",-0.08]
[1987,"ENSG00000079134.11","THOC1","chr18","-",260185,260304,264025,264092,259179,259275,265302,265363,1987,131161,"2,1","10,8","18,37",216,268,0,0,"0.988,0.995","0.408,0.212",0.681]
[2034,"ENSG00000178927.17","CYBC1","chr17","-",82449169,82449292,82449430,82449480,82445863,82445960,82450532,82450708,2034,"0,0","5,4","3,0","16,12",199,272,0.188825707091,0.343930351218197,"0.0,0.0","0.204,0.0",-0.102]
[2071,"ENSG00000182446.13","NPLOC4","chr17","-",81613317,81613494,81622165,81622278,81608727,81608822,81629724,81629805,2071,340351,"11,7",425404,"78,56",262,298,{"v":7.1054273576E-15,"d":"7.11E-15"},{"v":1.42801294541962E-13,"d":"1.43E-13"},"0.972,0.983","0.861,0.891",0.102]
[2136,"ENSG00000257949.6","TEN1","chr17","+",75986186,75986284,75991465,75991577,75979240,75979511,76000140,76000521,2136,95124,"2,3",114160,"4,7",247,261,0.192296681177,0.348371612739138,"0.98,0.978","0.968,0.96",0.015]
[2168,"ENSG00000167863.11","ATP5PD","chr17","-",75040091,75040163,75042180,75042277,75039208,75039271,75042528,75042659,2168,19522015,17241561,13091676,919944,246,221,0.0100969961486,0.0315446894414479,"0.504,0.537","0.561,0.615",-0.068]
[2220,"ENSG00000108604.15","SMARCD2","chr17","-",63836921,63837044,63837194,63837237,63835411,63835567,63837440,63837625,2220,103140,10891000,123158,747694,192,272,0.000165275346934,0.000849593175534213,"0.118,0.166","0.189,0.244",-0.074]
[2243,"ENSG00000146872.17","TLK2","chr17","+",62578476,62578574,62580110,62580192,62576708,62576775,62586134,62586226,2243,362322,224191,443373,230266,247,231,0.977591650748,1,"0.602,0.612","0.643,0.567",2E-3]
[2299,"ENSG00000169169.14","CPT1C","chr19","+",49700683,49700855,49701316,49701418,49697325,49697465,49701496,49701634,2299,"0,0","4,0","2,0","1,1",298,251,1,1,"0.0,NA","0.627,0.0",-0.314]
[2321,"ENSG00000008294.20","SPAG9","chr17","-",50970706,50970856,50974770,50974947,50962173,50966387,50977107,50977221,2321,221230,144196,195170,165145,298,298,0.394984564484,0.586615650696741,"0.605,0.54","0.542,0.54",0.031]
[2390,"ENSG00000161692.17","DBF4B","chr17","+",44722879,44723022,44729904,44730096,44709303,44709366,44730964,44731015,2390,185196,237236,149124,104122,292,298,0.0130703566179,0.0393459060621108,"0.443,0.459","0.594,0.509",-0.1]
[2429,"ENSG00000161654.9","LSM12","chr17","-",44037411,44037538,44040146,44040256,44034634,44036300,44063800,44063934,2429,783669,602702,555520,495548,259,276,0.544060916449,0.730082700172753,"0.581,0.504","0.544,0.503",0.019]
[2474,"ENSG00000168610.14","STAT3","chr17","-",42345558,42345657,42346568,42346713,42339313,42339409,42348388,42348517,2474,727873,428370,789730,354347,294,248,0.536845525403,0.724162941122651,"0.589,0.666","0.653,0.64",-0.019]
[2540,"ENSG00000278845.4","MRPL45","chr17","+",38306532,38306631,38318686,38318735,38299350,38299468,38320617,38320767,2540,482402,427395,470522,430365,248,198,0.218237401531,0.3830619619561,"0.474,0.448","0.466,0.533",-0.039]
[2557,"ENSG00000278311.4","GGNBP2","chr17","+",36554819,36554900,36557082,36557336,36545503,36545817,36560772,36560818,2557,100117,503458,170189,511606,230,298,0.0102961295736,0.0320909606587901,"0.205,0.249","0.301,0.288",-0.068]
[2617,"ENSG00000264538.6","SUZ12P1","chr17","+",30734896,30734943,30735032,30735097,30709607,30709811,30743300,30743369,2617,"16,5","81,49","27,31","49,58",196,214,{"v":2.32528516403e-05,"d":"2.33E-05"},0.000143653649575446,"0.177,0.1","0.376,0.369",-0.234]
[2685,"ENSG00000228315.11","GUSBP11","chr22","-",23683724,23683867,23709129,23709241,23659864,23660000,23709785,23709867,2685,"44,28","88,82","43,14","61,52",261,292,0.785108337188,0.920795449852655,"0.359,0.276","0.441,0.231",-0.019]
[2702,"ENSG00000141068.14","KSR1","chr17","+",27601359,27601401,27601892,27601958,27597267,27597436,27603833,27603888,2702,227297,"7,6",294283,"3,7",191,215,0.390897926224,0.582278275280234,"0.973,0.982","0.991,0.978",-0.007]
[2745,"ENSG00000141027.20","NCOR1","chr17","-",16058470,16058599,16061400,16061894,16057906,16058064,16062104,16062270,2745,571414,553507,594456,501479,298,278,0.220982553327,0.386521640254115,"0.491,0.432","0.525,0.47",-0.036]
[2785,"ENSG00000241837.6","ATP5PO","chr21","-",33907340,33907453,33912288,33912399,33903934,33904021,33914449,33914500,2785,42903602,43964038,30823150,25122711,260,262,0.0168160629138,0.048803941825132,"0.496,0.473","0.553,0.539",-0.062]
[2851,"ENSG00000129197.14","RPAIN","chr17","+",5426235,5426299,5428070,5428211,5422768,5422829,5432541,5432876,2851,"42,47",167130,"17,17","52,61",213,290,1,1,"0.255,0.33","0.308,0.275",1E-3]
[2874,"ENSG00000185722.17","ANKFY1","chr17","-",4165397,4167911,4169197,4169288,4163956,4164173,4170714,4170861,2874,"61,78","2,0","32,22","19,23",240,298,{"v":1.11022302463e-16,"d":"1.11E-16"},{"v":2.67083523987274e-15,"d":"2.67E-15"},"0.974,1.0","0.677,0.543",0.377]
[2931,"ENSG00000275066.4","SYNRG","chr17","-",37570636,37570885,37571790,37571987,37568790,37568924,37576340,37576418,2931,194183,"106,63",182217,160155,298,298,0.000847016878035,3.68972900980388E-3,"0.647,0.744","0.532,0.583",0.138]
[2996,"ENSG00000158545.15","ZC3H18","chr16","+",88625201,88625267,88627621,88627782,88624601,88624745,88627919,88628119,2996,101117,485530,190170,496512,215,298,0.000230276711316,0.00114189728107224,"0.224,0.234","0.347,0.315",-0.102]
[3003,"ENSG00000140948.11","ZCCHC14","chr16","-",87413054,87413195,87414413,87414541,87411411,87412976,87415275,87415367,3003,"82,66","92,73","55,38","101,73",277,290,0.00809189084854,0.0262248226562592,"0.483,0.486","0.363,0.353",0.127]
[3087,"ENSG00000102967.11","DHODH","chr16","+",72014472,72014672,72017023,72017106,72012049,72012262,72024144,72024238,3087,165205,"6,1",80106,"6,11",298,232,2.81346650404E-4,1.36860313659395E-3,"0.955,0.994","0.912,0.882",0.077]
[3104,"ENSG00000189091.12","SF3B3","chr16","+",70541668,70541834,70544437,70544533,70539103,70539207,70548369,70548442,3104,12511292,710743,254262,281315,298,245,{"v":6.2942505652e-09,"d":"6.29E-09"},{"v":6.65531839762253E-8,"d":"6.66E-08"},"0.592,0.588","0.426,0.406",0.174]
[3167,"ENSG00000102898.11","NUTF2","chr16","+",67847277,67847456,67865101,67865229,67846934,67846985,67868339,67868411,3167,"2,3",23142170,"12,9",25243171,298,277,1,1,"0.001,0.001","0.004,0.003",-0.003]
[3203,"ENSG00000103042.8","SLC38A7","chr16","-",58678695,58678894,58679856,58680241,58678332,58678474,58683954,58684178,3203,"85,62","78,68","40,38","26,53",298,298,0.942229835913,1,"0.521,0.477","0.606,0.418",-0.013]
[3260,"ENSG00000089280.18","FUS","chr16","+",31183857,31184002,31184208,31184396,31182512,31182664,31184938,31185179,3260,25292526,294315,22332195,282305,294,298,0.420675211718,0.61293795820182,"0.897,0.89","0.889,0.879",0.009]
[3324,"ENSG00000261832.6","AC138894.1","chr16","-",28488590,28488662,28491481,28491560,28487455,28487541,28491713,28491835,3324,127104,"3,9",72106,"48,50",228,221,{"v":1.11022302463e-16,"d":"1.11E-16"},{"v":2.67083523987274e-15,"d":"2.67E-15"},"0.976,0.918","0.592,0.673",0.315]
[3335,"ENSG00000205629.11","LCMT1","chr16","+",25140170,25140247,25161101,25161204,25132401,25132523,25164597,25164718,3335,160129,261259,133190,"29,44",226,252,0,0,"0.406,0.357","0.836,0.828",-0.45]
[3410,"ENSG00000072864.14","NDE1","chr16","+",15667285,15667439,15672689,15672771,15664735,15664861,15677800,15677949,3410,627594,"0,0",982925,"0,2",298,231,1,1,"1.0,1.0","1.0,0.997",2E-3]
[3431,"ENSG00000103342.12","GSPT1","chr16","-",11886776,11886931,11887569,11887750,11886470,11886611,11891061,11891139,3431,18841502,22281954,12901227,15941517,298,298,0.980093993388,1,"0.458,0.435","0.447,0.447",-1E-3]
[3512,"ENSG00000162086.14","ZNF75A","chr16","+",3312676,3312768,3316911,3317022,3311752,3311948,3317189,3317252,3512,137129,"63,60",169169,192189,241,260,{"v":4.6511978713e-08,"d":"4.65E-08"},{"v":4.38545957516811e-07,"d":"4.39E-07"},"0.701,0.699","0.487,0.491",0.211]
[3555,"ENSG00000270011.7","ZNF559-ZNF177","chr19","+",9364861,9364948,9376315,9376423,9357827,9357904,9378258,9378344,3555,"3,0","34,14","2,1",122152,236,257,0.464507577962,0.655139085382473,"0.088,0.0","0.018,0.007",0.032]
[3576,"ENSG00000162039.15","MEIOB","chr16","-",1837783,1837870,1839254,1839438,1833987,1834366,1841819,1841973,3576,440384,188203,"57,48","35,25",298,236,0.386004617782,0.57722687526789,"0.65,0.6","0.563,0.603",0.042]
[3640,"ENSG00000104774.12","MAN2B1","chr19","-",12658427,12658510,12661259,12661376,12658223,12658344,12663316,12663462,3640,489506,272280,373392,213188,266,232,0.655172169119,0.823602073846638,"0.611,0.612","0.604,0.645",-0.013]
[3655,"ENSG00000131115.15","ZNF227","chr19","+",44217790,44217852,44228445,44228572,44213086,44213244,44229732,44229816,3655,"85,61","95,95","38,40",452475,211,276,0,0,"0.539,0.456","0.099,0.099",0.399]
[3720,"ENSG00000140526.17","ABHD2","chr15","+",89188192,89188303,89191079,89191149,89185414,89185516,89193234,89193453,3720,15711473,598704,17651853,834788,260,219,0.657002099231,0.824841044176193,"0.689,0.638","0.641,0.665",0.01]
[3766,"ENSG00000164828.17","SUN1","chr7","+",817279,817499,832504,832601,816614,816673,838797,838986,3766,"2,2",123147,"0,1","87,86",298,246,1,1,"0.013,0.011","0.0,0.01",0.007]
[3802,"ENSG00000241685.9","ARPC1A","chr7","+",99344292,99344515,99348851,99348959,99338180,99338285,99353908,99354121,3802,853815,350335,578601,254293,298,257,0.323446925398,0.510216860907586,"0.678,0.677","0.662,0.639",0.027]
[3865,"ENSG00000049323.15","LTBP1","chr2","+",33309433,33309556,33342837,33342963,33301521,33301644,33347366,33347409,3865,247207,209178,262266,109120,272,275,{"v":2.68302192741e-06,"d":"2.68E-06"},{"v":1.94970309466284e-05,"d":"1.95E-05"},"0.544,0.54","0.708,0.691",-0.157]
[3883,"ENSG00000125844.15","RRBP1","chr20","-",17625511,17625602,17627347,17627382,17624575,17624668,17627503,17627682,3883,"48,70",322289,"65,77",236228,184,240,0.00924497672834,0.0292942296021818,"0.163,0.24","0.264,0.306",-0.084]
[3953,"ENSG00000111860.13","CEP85L","chr6","-",118491685,118491865,118511297,118511415,118483705,118483858,118523801,118523920,3953,"24,20","33,61","19,33","58,34",267,298,0.692232752002,0.851812181723638,"0.448,0.268","0.268,0.52",-0.036]
[3968,"ENSG00000153975.9","ZUP1","chr6","-",116660735,116660846,116666633,116667207,116658802,116658924,116668565,116668794,3968,121101,183179,282258,148137,298,260,{"v":3.2640556924e-14,"d":"3.26E-14"},{"v":6.1578562008846e-13,"d":"6.16E-13"},"0.366,0.33","0.624,0.622",-0.275]
[4038,"ENSG00000161040.16","FBXL13","chr7","-",102822039,102822203,102877466,102877593,102813229,102813531,102878330,102878450,4038,"101,97",124131,141143,"72,74",276,298,{"v":5.64936849523E-8,"d":"5.65E-08"},{"v":5.25831237445413e-07,"d":"5.26E-07"},"0.468,0.444","0.679,0.676",-0.221]
[4088,"ENSG00000119899.12","SLC17A5","chr6","-",73636620,73636707,73638411,73638499,73635232,73635500,73641690,73641924,4088,"25,33","55,48","49,51","46,45",237,236,0.00694166511082,0.0229337264189111,"0.312,0.406","0.515,0.53",-0.163]
[4119,"ENSG00000135336.14","ORC3","chr6","+",87657920,87658018,87664742,87664859,87656902,87656982,87665753,87665833,4119,233225,315255,178180,243201,247,266,0.987511310799,1,"0.443,0.487","0.441,0.491",-1E-3]
[4188,"ENSG00000188672.18","RHCE","chr1","-",25370466,25370540,25385710,25385844,25362248,25362553,25388975,25389113,4188,"53,64","61,39","14,26","40,55",283,223,3.56649890639E-4,1.69205371468912E-3,"0.406,0.564","0.216,0.271",0.241]
[4221,"ENSG00000124608.4","AARS2","chr6","-",44302801,44302910,44303065,44303175,44302390,44302513,44303285,44303423,4221,"98,80",148153,"99,93",157123,259,258,0.359652487428,0.550366528639905,"0.397,0.342","0.386,0.43",-0.038]
[4268,"ENSG00000165055.15","METTL2B","chr7","+",128479157,128479513,128480646,128480696,128477948,128477992,128488100,128488161,4268,"0,0","49,36","7,11","35,32",298,199,{"v":9.99255029832e-08,"d":"9.99E-08"},{"v":8.94868922490841e-07,"d":"8.95E-07"},"0.0,0.0","0.118,0.187",-0.152]
[4290,"ENSG00000096070.19","BRPF3","chr6","+",36222167,36222265,36228901,36229056,36217916,36218010,36230425,36231317,4290,"93,88","53,68","35,67","21,32",247,298,0.266916627463,0.444544489101337,"0.679,0.61","0.668,0.716",-0.047]
[4348,"ENSG00000135093.12","USP30","chr12","+",109081333,109081393,109081932,109082019,109073437,109073532,109082662,109082743,4348,"34,37","13,32","33,33","17,22",209,236,0.959425157728,1,"0.747,0.566","0.687,0.629",-2E-3]
[4371,"ENSG00000204420.9","MPIG6B","chr6","+",31724141,31724232,31724586,31724627,31723638,31723986,31724745,31724844,4371,11811226,465483,122140,469547,240,190,0,0,"0.668,0.668","0.171,0.168",0.499]
[4433,"ENSG00000105197.10","TIMM50","chr19","+",39485687,39485807,39486186,39486291,39485543,39485602,39486396,39486495,4433,12721477,10841169,235254,487512,269,254,{"v":7.32747196253e-15,"d":"7.33E-15"},{"v":1.47000863862577E-13,"d":"1.47E-13"},"0.526,0.544","0.313,0.319",0.219]
[4504,"ENSG00000151422.12","FER","chr5","+",108768092,108768238,108798123,108798389,108748961,108748993,108867766,108867950,4504,"4,3","1,7","12,5","1,0",295,298,0.000223883171928,1.11268104181602E-3,"0.802,0.302","0.924,1.0",-0.41]
[4538,"ENSG00000028528.14","SNX1","chr15","+",64118116,64118244,64123502,64123546,64112572,64112684,64126078,64126220,4538,682728,280346,673694,239269,277,193,0.151560069851,0.291035228568679,"0.629,0.594","0.662,0.643",-0.041]
[4586,"ENSG00000205268.10","PDE7A","chr8","-",65727169,65727301,65734793,65734894,65726874,65726966,65739501,65739597,4586,370270,324328,317230,283305,250,281,0.744265635575,0.890682769250949,"0.562,0.481","0.557,0.459",0.014]
[4603,"ENSG00000017260.19","ATP2C1","chr3","+",130967144,130967240,130967329,130967419,130964947,130965045,130969291,130969396,4603,337393,224173,429370,183144,245,239,0.0683415474352,0.155076371371592,"0.595,0.689","0.696,0.715",-0.064]
[4667,"ENSG00000161010.14","MRNIP","chr5","-",179851242,179851424,179853196,179853276,179847977,179848066,179853377,179853437,4667,"34,37","10,9","8,17","0,2",229,298,0.0055522118007,0.0189651333155865,"0.816,0.843","1.0,0.917",-0.129]
[4731,"ENSG00000176095.11","IP6K1","chr3","-",49738211,49738422,49747817,49748168,49732790,49732972,49786353,49786540,4731,230264,365365,183205,370294,298,298,0.322319354947,0.509403783238668,"0.387,0.42","0.331,0.411",0.032]
[4752,"ENSG00000111653.19","ING4","chr12","-",6652935,6653050,6656726,6656798,6652661,6652767,6663064,6663114,4752,"1,1",135168,"4,8",303371,221,264,0.138884234627,0.271828385699831,"0.009,0.007","0.016,0.025",-0.013]
[4800,"ENSG00000196696.12","PDXDC2P-NPIPB14P","chr16","-",69996389,69996468,70010750,70010856,69996068,69996226,70011840,70011929,4800,"27,17","49,30","6,8","30,14",255,228,0.153862923643,0.29454559964378,"0.33,0.336","0.152,0.338",0.088]
[4835,"ENSG00000066322.14","ELOVL1","chr1","-",43364614,43364647,43364927,43365008,43364323,43364460,43365563,43365623,4835,"16,23","5,6",365366,"34,30",230,182,0.0159962206395,0.0467871754164183,"0.717,0.752","0.895,0.906",-0.166]
[4901,"ENSG00000170632.13","ARMC10","chr7","+",103086629,103086764,103086868,103086937,103083681,103083830,103097276,103097348,4901,429465,"0,2",405397,"3,4",284,218,1,1,"1.0,0.994","0.99,0.987",0.009]
[4929,"ENSG00000163507.13","CIP2A","chr3","-",108582107,108582138,108585064,108585212,108581414,108581511,108589273,108589452,4929,426389,"85,78",168228,"12,19",297,180,{"v":7.78108249821e-06,"d":"7.78E-06"},{"v":5.22045812637445e-05,"d":"5.22E-05"},"0.752,0.751","0.895,0.879",-0.135]
[4989,"ENSG00000198756.11","COLGALT2","chr1","-",183945431,183945564,183951006,183951113,183944195,183944323,183954761,183954838,4989,"51,55","45,65","36,18","11,27",256,282,0.384063178661,0.575301037422267,"0.555,0.482","0.783,0.423",-0.085]
[5053,"ENSG00000070501.11","POLB","chr8","+",42349015,42349090,42355515,42355567,42344952,42345019,42357168,42357203,5053,151124,139144,107166,138147,224,201,0.880955596211,0.985934149964106,"0.494,0.436","0.41,0.503",0.008]
[5070,"ENSG00000070501.11","POLB","chr8","+",42369270,42369335,42369848,42369988,42362611,42362698,42371562,42371765,5070,170135,328331,256317,227237,214,289,{"v":5.20250509339e-13,"d":"5.20E-13"},{"v":8.71051318505066e-12,"d":"8.71E-12"},"0.412,0.355","0.604,0.644",-0.241]
[5116,"ENSG00000135365.15","PHF21A","chr11","-",46092182,46092223,46118741,46118800,46084165,46084302,46119723,46119787,5116,"1,0","1,10","1,2","14,8",208,190,0.314109036128,0.50076031877111,"0.477,0.0","0.061,0.186",0.115]
[5156,"ENSG00000145715.14","RASA1","chr5","+",87380508,87380595,87383712,87383780,87379734,87379850,87385300,87385389,5156,118124,"88,59","85,71","113,80",236,217,0.000401488650473,0.00188383376745654,"0.552,0.659","0.409,0.449",0.177]
[5222,"ENSG00000145687.16","SSBP2","chr5","-",81489249,81489309,81513627,81513717,81474495,81474562,81615472,81615557,5222,"75,54","56,53","33,39",50112,239,209,2.0414066507E-4,0.0010265972702457,"0.539,0.471","0.366,0.233",0.206]
[5253,"ENSG00000164306.10","PRIMPOL","chr4","+",184678231,184678394,184685575,184685684,184672172,184672460,184691498,184691581,5253,"101,63",145136,"12,15","67,72",298,258,{"v":7.73990440361e-06,"d":"7.74E-06"},{"v":5.19438208018856E-5,"d":"5.19E-05"},"0.376,0.286","0.134,0.153",0.187]
[5307,"ENSG00000089006.16","SNX5","chr20","-",17953995,17954117,17956932,17957037,17952586,17952710,17968374,17968457,5307,453522,13871332,404428,12661237,254,271,0.514554171105,0.70225297334996,"0.258,0.295","0.254,0.27",0.014]
[5374,"ENSG00000007341.18","ST7L","chr1","-",112582374,112582472,112591524,112591603,112578344,112578417,112597970,112598086,5374,"53,46","6,6","17,11","4,0",228,247,0.73993624504,0.887978822293636,"0.905,0.893","0.822,1.0",-0.012]
[5384,"ENSG00000007341.18","ST7L","chr1","-",112591524,112591603,112600793,112600848,112582374,112582472,112610840,112611003,5384,"48,34","7,6","12,24","3,5",204,228,0.686099247029,0.847059917913183,"0.885,0.864","0.817,0.843",0.045]
[5451,"ENSG00000151651.15","ADAM8","chr10","-",133268747,133268862,133269444,133269529,133267928,133268118,133269896,133269974,5451,"3,13","16,18","10,6","32,28",234,264,0.362598391199,0.553291901653672,"0.175,0.449","0.261,0.195",0.084]
[5472,"ENSG00000251443.1","LINC02160","chr5","+",33244851,33245056,33248541,33248651,33229734,33229858,33255475,33255553,5472,175165,"34,23","71,52","6,0",298,259,0.000446657022353,0.00207439781629796,"0.817,0.862","0.911,1.0",-0.116]
[5557,"ENSG00000114982.17","KANSL3","chr2","-",96602115,96602338,96602752,96602862,96601642,96601776,96604249,96604380,5557,238226,201231,186251,148121,259,298,0.0215385338136,0.0602001886127352,"0.577,0.53","0.591,0.705",-0.094]
[5608,"ENSG00000124795.15","DEK","chr6","-",18226173,18226242,18236451,18236596,18224216,18225730,18237380,18237516,5608,"12,7",606513,"33,23",630595,294,218,1.68616494731E-4,8.64987219203387E-4,"0.014,0.01","0.037,0.028",-0.021]
[5625,"ENSG00000064687.12","ABCA7","chr19","+",1056906,1057084,1057313,1057429,1056329,1056499,1057914,1058059,5625,115116,"53,49","22,46","14,20",298,265,0.679721136561,0.841514916380467,"0.659,0.678","0.583,0.672",0.041]
[5692,"ENSG00000091106.18","NLRC4","chr2","-",32249606,32251601,32252418,32252679,32241032,32241125,32256774,32256893,5692,"5,14","7,6","32,7","10,7",298,298,0.545377943153,0.731084672078189,"0.417,0.7","0.762,0.5",-0.073]
[5709,"ENSG00000132405.18","TBC1D14","chr4","+",6999084,6999202,7014447,7014557,6996324,6996407,7025003,7025262,5709,400439,348343,207204,224216,267,259,0.0468578347266,0.114129939129753,"0.527,0.554","0.473,0.478",0.065]
[5777,"ENSG00000170180.21","GYPA","chr4","-",144118713,144118752,144119685,144119781,144116853,144116939,144120489,144120588,5777,793636,1171921,29512758,349386,245,188,0,0,"0.342,0.346","0.866,0.846",-0.512]
[5795,"ENSG00000011405.13","PIK3C2A","chr11","-",17145862,17145942,17148666,17148787,17145667,17145731,17150497,17150655,5795,"31,54","40,43","28,15","51,63",270,229,1.41552906738E-3,0.00582092287975132,"0.397,0.516","0.318,0.168",0.214]
[5880,"ENSG00000101290.13","CDS2","chr20","+",5185757,5185826,5186686,5186839,5184857,5184945,5189066,5189186,5880,136102,592557,95101,298274,218,298,0.000635987926653,0.00286487825259949,"0.239,0.2","0.304,0.335",-0.1]
[5920,"ENSG00000130340.15","SNX9","chr6","+",157875050,157875176,157896826,157896998,157873101,157873176,157901897,157902045,5920,127102,"118,98",144138,"136,75",275,298,0.210306647416,0.372987612344313,"0.538,0.53","0.534,0.666",-0.066]
[5942,"ENSG00000133318.13","RTN3","chr11","+",63752506,63752645,63753068,63753138,63749990,63750198,63753661,63753708,5942,16741626,12801212,12811292,867987,288,219,0.656141673153,0.824282783051272,"0.499,0.505","0.529,0.499",-0.012]
[6016,"ENSG00000168297.15","PXK","chr3","+",58369430,58369478,58382513,58382700,58365873,58365924,58390581,58390659,6016,"13,10","92,78","7,16","81,82",197,298,0.905475993755,1,"0.176,0.162","0.116,0.228",-0.003]
[6028,"ENSG00000138641.16","HERC3","chr4","+",88662430,88662555,88664152,88664212,88658414,88658491,88667376,88667488,6028,"84,66","37,26","17,33","10,18",274,209,0.346742969874,0.536420255446082,"0.634,0.659","0.565,0.583",0.073]
[6127,"ENSG00000167543.15","TP53I13","chr17","+",29569317,29569359,29571590,29571719,29568590,29569086,29571856,29572057,6127,"58,58","46,64","32,36","51,48",191,278,0.0624157444449,0.144044716714508,"0.647,0.569","0.477,0.522",0.108]
[6177,"ENSG00000118495.19","PLAGL1","chr6","-",143968906,143968978,143985134,143985174,143940301,143942663,144064467,144064599,6177,"0,2","3,9","0,2","12,4",189,221,0.616830823946,0.790710393840864,"0.0,0.206","0.0,0.369",-0.082]
[6211,"ENSG00000272305.5","AC096887.1","chr3","-",53085749,53085852,53092368,53092618,53077687,53077828,53099380,53099453,6211,431407,"2,1","88,91","1,7",298,252,0.0078657267804,0.0255730017405306,"0.995,0.997","0.987,0.917",0.044]
[6276,"ENSG00000112984.11","KIF20A","chr5","+",138179659,138179845,138181421,138181511,138178997,138179202,138181608,138181728,6276,194188,208219,197237,179201,298,239,0.0845759895498,0.184069925338478,"0.428,0.408","0.469,0.486",-0.059]
[6310,"ENSG00000148634.15","HERC4","chr10","-",68014025,68014186,68025545,68025676,67992605,67992682,68032777,68032869,6310,135132,183182,"45,65","102,91",280,298,0.202298234427,0.36192682772038,"0.44,0.436","0.32,0.432",0.062]
[6360,"ENSG00000103274.10","NUBP1","chr16","+",10761363,10761474,10767948,10768032,10757872,10758027,10769046,10769351,6360,225259,270337,340284,354312,260,233,0.223152662831,0.388894530454489,"0.428,0.408","0.463,0.449",-0.038]
[6377,"ENSG00000157796.17","WDR19","chr4","+",39194543,39194659,39199477,39199593,39189655,39189781,39203641,39203722,6377,"10,17","22,28","12,14","28,15",265,265,0.726174778601,0.877178212759107,"0.312,0.378","0.3,0.483",-0.046]
[6442,"ENSG00000120253.13","NUP43","chr6","-",149736470,149736622,149738642,149738778,149731397,149731735,149743637,149743715,6442,"4,10",584443,"31,15",537492,285,298,{"v":5.15420177385e-05,"d":"5.15E-05"},0.00029543306034856,"0.007,0.023","0.057,0.031",-0.029]
[6496,"ENSG00000162961.13","DPY30","chr2","-",32029593,32029736,32039278,32039326,32023891,32024256,32039420,32039492,6496,123126,12841057,131178,894826,197,292,0.00012875443625,0.000678626185339256,"0.124,0.15","0.178,0.242",-0.073]
[6525,"ENSG00000124571.17","XPO5","chr6","-",43549892,43549934,43551297,43551453,43549488,43549578,43553372,43553503,6525,749656,164145,"79,63","22,45",298,191,0.0192213464849,0.0547590255064305,"0.745,0.744","0.697,0.473",0.159]
[6590,"ENSG00000168924.14","LETM1","chr4","-",1825563,1825683,1832743,1832947,1823643,1823775,1834844,1834982,6590,360387,464546,353354,423436,298,269,0.390584871616,0.58192768916782,"0.412,0.39","0.43,0.423",-0.025]
[6624,"ENSG00000164190.17","NIPBL","chr5","+",37052365,37052566,37058890,37059165,37050942,37051886,37060843,37061018,6624,421405,521441,573631,710736,298,298,0.776532258436,0.914939869680046,"0.447,0.479","0.447,0.462",0.008]
[6671,"ENSG00000133657.15","ATP13A3","chr3","-",194453705,194453778,194454257,194454392,194450144,194450276,194455892,194455962,6671,225175,137118,181155,"129,91",284,222,0.901426805926,0.999465033424687,"0.562,0.537","0.523,0.571",0.003]
[6692,"ENSG00000163002.12","NUP35","chr2","+",183151507,183151649,183157443,183157513,183133565,183133623,183158282,183158411,6692,328286,162126,"93,70",104116,291,219,{"v":1.07551423323E-9,"d":"1.08E-09"},{"v":1.25536256137375e-08,"d":"1.26E-08"},"0.604,0.631","0.402,0.312",0.26]
[6754,"ENSG00000163882.9","POLR2H","chr3","+",184364965,184365049,184365132,184365226,184362872,184363565,184366716,184366800,6754,350398,578488,266259,412467,233,243,0.214139085593,0.37791399429771,"0.387,0.46","0.402,0.366",0.039]
[6816,"ENSG00000177058.11","SLC38A9","chr5","-",55649206,55649314,55656714,55656774,55645788,55645895,55664692,55664863,6816,"38,51","67,40","9,6","9,17",209,257,0.438739491013,0.630551210411353,"0.411,0.611","0.552,0.303",0.084]
[6844,"ENSG00000113456.18","RAD1","chr5","-",34909257,34909356,34911553,34911812,34908553,34908948,34914694,34914961,6844,"112,68",450384,299274,211181,298,248,0,0,"0.172,0.128","0.541,0.557",-0.399]
[6891,"ENSG00000114859.15","CLCN2","chr3","-",184353541,184353795,184354100,184354314,184353249,184353422,184354547,184354658,6891,"26,18","2,0","47,45","1,1",298,298,0.5838405512,0.763352723314005,"0.929,1.0","0.979,0.978",-0.014]
[6929,"ENSG00000196865.4","NHLRC2","chr10","+",113884250,113884380,113898109,113898209,113879573,113879695,113901665,113901897,6929,"85,90","65,58","71,64","43,30",279,249,0.20196160187,0.361468474782302,"0.539,0.581","0.596,0.656",-0.066]
[6994,"ENSG00000243989.8","ACY1","chr3","+",51985206,51985271,51985400,51985465,51984046,51984158,51985851,51985946,6994,"143,91",144138,"8,46","44,63",214,214,0.0612289082511,0.141830138092161,"0.498,0.397","0.154,0.422",0.16]
[7024,"ENSG00000110514.19","MADD","chr11","+",47286432,47286534,47288967,47289027,47284940,47285194,47289390,47289493,7024,203216,"8,3","52,48","5,6",251,209,0.00449836786614,0.0158457918643557,"0.955,0.984","0.896,0.869",0.087]
[7079,"ENSG00000140694.16","PARN","chr16","-",14627105,14627187,14627268,14627336,14617589,14617650,14628171,14628251,7079,185149,271203,97130,91108,217,231,0.00225554028987,0.00871834418941837,"0.421,0.439","0.532,0.562",-0.117]
[7143,"ENSG00000004399.12","PLXND1","chr3","-",129560688,129560723,129561645,129561709,129560329,129560434,129561799,129561903,7143,194224,129119,"61,60","67,94",213,184,{"v":1.53018889518E-5,"d":"1.53E-05"},{"v":9.80097328557566e-05,"d":"9.80E-05"},"0.565,0.619","0.44,0.355",0.195]
[7164,"ENSG00000132394.10","EEFSEC","chr3","+",128264616,128264781,128358216,128358373,128262127,128262224,128408068,128408646,7164,210218,190208,122127,149133,298,298,0.186970069178,0.341519428043287,"0.525,0.512","0.45,0.488",0.049]
[7209,"ENSG00000198692.9","EIF1AY","chrY","+",20579607,20579691,20582589,20582693,20575793,20575887,20588023,20588105,7209,207267,"15,4",192219,211227,233,253,0,0,"0.937,0.986","0.497,0.512",0.457]
[7242,"ENSG00000206527.9","HACD2","chr3","-",123528385,123528474,123567761,123567780,123502559,123502681,123582211,123582329,7242,"8,11","131,95","15,9","108,86",168,238,0.245033914524,0.417213208939798,"0.08,0.141","0.164,0.129",-0.036]
[7308,"ENSG00000151445.15","VIPAS39","chr14","-",77434261,77434303,77435258,77435393,77433841,77433931,77435843,77435919,7308,282214,"62,61",122141,"20,25",284,191,0.0641978324377,0.147430610899701,"0.754,0.702","0.804,0.791",-0.07]
[7337,"ENSG00000149516.13","MS4A3","chr11","+",60064261,60064318,60066950,60067112,60061489,60061554,60069573,60069675,7337,"10,18",38483301,"30,39",17041661,206,298,{"v":2.19948137481e-09,"d":"2.20E-09"},{"v":2.46607520013003E-8,"d":"2.47E-08"},"0.004,0.008","0.025,0.033",-0.023]
[7390,"ENSG00000186001.13","LRCH3","chr3","+",197854391,197854445,197865422,197865471,197852560,197852620,197870159,197870278,7390,"51,36","10,13","22,24","28,17",203,198,2.90910790152E-4,1.40993842621339E-3,"0.833,0.73","0.434,0.579",0.275]
[7459,"ENSG00000124207.16","CSE1L","chr20","+",49076979,49077064,49078560,49078622,49075317,49075520,49084025,49084162,7459,671647,720690,217241,250233,234,211,0.917010883052,1,"0.457,0.458","0.439,0.483",-0.003]
[7472,"ENSG00000059378.12","PARP12","chr7","-",140034234,140034331,140041643,140041839,140028612,140028688,140046883,140047007,7472,"93,76","72,82","22,15","33,53",298,246,0.0018134852783,0.00723622815097188,"0.516,0.433","0.355,0.189",0.203]
[7545,"ENSG00000137812.19","KNL1","chr15","+",40640911,40641027,40644996,40645087,40629272,40629371,40645655,40645772,7545,197150,148179,108149,105108,265,240,0.515183361425,0.702918080389745,"0.547,0.431","0.482,0.555",-0.029]
[7563,"ENSG00000168374.10","ARF4","chr3","-",57575547,57575673,57583897,57584007,57571362,57572298,57584383,57584464,7563,513389,940915,330290,724894,259,275,0.062601975227,0.144385524674139,"0.367,0.311","0.326,0.256",0.048]
[7649,"ENSG00000169499.14","PLEKHA2","chr8","+",38943788,38943837,38946123,38946221,38935993,38936050,38950849,38950990,7649,"85,73",187199,"55,54",161195,198,247,0.0968783865013,0.205399499703485,"0.362,0.314","0.299,0.257",0.06]
[7690,"ENSG00000069248.11","NUP133","chr1","-",229475637,229475732,229477596,229477760,229470579,229470804,229484053,229484145,7690,693732,408385,159187,147133,298,244,0.00621393795347,0.0208513996231358,"0.582,0.609","0.47,0.535",0.093]
[7710,"ENSG00000143093.14","STRIP1","chr1","+",110046679,110046751,110047541,110047616,110045014,110045078,110047771,110047869,7710,195206,151119,227185,142119,221,224,0.70869558515,0.864055624436233,"0.567,0.637","0.618,0.612",-0.013]
[7774,"ENSG00000157869.14","RAB28","chr4","-",13474317,13474406,13479429,13479526,13381490,13381594,13484075,13484331,7774,"65,42","11,9","42,58","5,18",246,238,0.68427414798,0.845335156749649,"0.851,0.819","0.89,0.757",0.011]
[7796,"ENSG00000118873.15","RAB3GAP2","chr1","-",220157801,220157876,220159385,220159421,220157269,220157488,220162197,220162268,7796,"58,62",113116,"34,27","49,57",185,224,0.702932293236,0.860194296335261,"0.383,0.393","0.457,0.364",-0.022]
[7860,"ENSG00000077254.14","USP33","chr1","-",77739264,77739417,77740876,77740939,77736055,77736158,77741375,77741429,7860,117138,602663,164142,746585,212,298,0.321500837384,0.508449983681549,"0.215,0.226","0.236,0.254",-0.024]
[7882,"ENSG00000143476.17","DTL","chr1","+",212044659,212044758,212047150,212047212,212042992,212043118,212047296,212047417,7882,342312,269268,"55,50",71135,248,211,0.000289804168506,0.00140548453748355,"0.52,0.498","0.397,0.24",0.191]
[7970,"ENSG00000136731.12","UGGT1","chr2","+",128174772,128174858,128176813,128176898,128173780,128173939,128177831,128177920,7970,238233,246304,194196,182235,235,234,0.518532129821,0.706006446842115,"0.491,0.433","0.515,0.454",-0.023]
[8009,"ENSG00000149182.14","ARFGAP2","chr11","-",47171663,47171800,47175850,47175923,47168122,47168251,47176515,47176634,8009,244262,"0,0",153161,"63,48",222,286,0,0,"1.0,1.0","0.758,0.812",0.215]
[8030,"ENSG00000058673.16","ZC3H11A","chr1","+",203801574,203801628,203802956,203803016,203796292,203796496,203816925,203817124,8030,"76,69",334367,"5,6",403378,203,209,0,0,"0.19,0.162","0.013,0.016",0.161]
[8105,"ENSG00000116750.13","UCHL5","chr1","-",193029531,193029657,193049745,193049851,193029387,193029449,193051753,193051817,8105,864808,16371438,368469,775801,255,275,0.791436242869,0.92507834058282,"0.363,0.377","0.339,0.387",0.007]
[8119,"ENSG00000116539.12","ASH1L","chr1","-",155438326,155439068,155459796,155459898,155415743,155415923,155477885,155482449,8119,"94,68",142177,"95,92",134138,251,298,0.141128160713,0.2753089636274,"0.44,0.313","0.457,0.442",-0.073]
[8184,"ENSG00000109685.17","NSD2","chr4","+",1892165,1892263,1893729,1893909,1871433,1871542,1900625,1900766,8184,"29,28","59,44","6,6","17,26",247,298,0.04438001015,0.10913587042359,"0.372,0.434","0.299,0.218",0.145]
[8236,"ENSG00000165995.19","CACNB2","chr10","+",18536100,18536196,18538179,18538365,18534075,18534227,18539229,18539669,8236,"23,30","37,61","33,43","52,78",245,298,0.749469424642,0.894094599229499,"0.431,0.374","0.436,0.401",-0.016]
[8267,"ENSG00000115204.14","MPV17","chr2","-",27312993,27313154,27317077,27317234,27312679,27312772,27322447,27322522,8267,"10,11",602538,"8,6",170151,298,298,0.0442588015145,0.108883645219331,"0.016,0.02","0.045,0.038",-0.023]
[8328,"ENSG00000234741.7","GAS5","chr1","-",173864674,173864704,173865470,173865547,173864483,173864506,173865856,173865894,8328,23512123,726592,44274733,11191466,226,179,0.66533278447,0.830889413864852,"0.719,0.74","0.758,0.719",-0.009]
[8364,"ENSG00000234741.7","GAS5","chr1","-",173866176,173866206,173866527,173866796,173865856,173865894,173866990,173867043,8364,641706,16321350,432476,30693274,298,179,0,0,"0.191,0.239","0.078,0.08",0.136]
[8410,"ENSG00000223546.6","LINC00630","chrX","+",102845856,102846020,102865041,102865152,102839800,102839863,102884142,102885406,8410,"1,1","9,8","1,0","1,2",298,260,0.248817716501,0.422425512221076,"0.088,0.098","0.466,0.0",-0.14]
[8427,"ENSG00000141429.13","GALNT1","chr18","+",35663627,35663802,35677590,35677757,35654559,35654801,35683390,35683598,8427,732710,708744,670737,714729,298,298,0.866765382091,0.977393701858748,"0.508,0.488","0.484,0.503",0.005]
[8493,"ENSG00000143179.15","UCK2","chr1","+",165896189,165896332,165903181,165903279,165891225,165891322,165905920,165905969,8493,678628,822863,254329,561560,292,247,0.000619291504066,2.79751926112966E-3,"0.411,0.381","0.277,0.332",0.092]
[8549,"ENSG00000115020.16","PIKFYVE","chr2","+",208277536,208277708,208285725,208285933,208276711,208276830,208288728,208288818,8549,"102,90",171167,"25,25","68,86",298,298,0.00585677832119,0.019848559894241,"0.374,0.35","0.269,0.225",0.115]
[8574,"ENSG00000179406.7","LINC00174","chr7","-",66455658,66455853,66467681,66467719,66450070,66450236,66476258,66476327,8574,"3,2","6,8","2,0","1,0",187,298,1,1,"0.443,0.285","0.761,NA",-0.397]
[8640,"ENSG00000169180.11","XPO6","chr16","-",28121669,28121762,28125688,28125848,28112903,28113050,28132333,28132403,8640,535673,"16,7",288299,"29,44",298,242,{"v":1.21014309684E-14,"d":"1.21E-14"},{"v":2.37059330801202e-13,"d":"2.37E-13"},"0.964,0.987","0.89,0.847",0.107]
[8676,"ENSG00000137710.15","RDX","chr11","-",109990755,109990789,110124058,110124270,109864294,109864719,110131435,110131730,8676,"18,5","0,1","0,1","0,0",298,183,1,1,"1.0,0.754","NA,1.0",-0.123]
[8728,"ENSG00000116266.10","STXBP3","chr1","+",108800219,108800305,108807400,108807549,108798144,108798237,108808782,108809526,8728,254207,242183,109126,168191,235,298,0.000520890812781,0.00238320009618739,"0.571,0.589","0.451,0.455",0.127]
[8751,"ENSG00000113300.11","CNOT6","chr5","+",180569109,180569340,180571229,180571432,180567848,180568003,180573987,180578349,8751,281242,310323,221211,200153,298,298,0.00344791030788,0.0125989749077501,"0.475,0.428","0.525,0.58",-0.101]
[8819,"ENSG00000173473.10","SMARCC1","chr3","-",47662333,47662592,47670657,47670717,47661293,47661455,47675474,47675588,8819,319303,11891133,236256,816797,209,298,0.28822601527,0.47026550763233,"0.277,0.276","0.292,0.314",-0.026]
[8882,"ENSG00000117000.8","RLF","chr1","+",40202411,40202614,40231516,40231658,40195631,40195764,40235791,40240921,8882,"114,81","103,66",118117,"112,65",298,291,0.458130010408,0.649157432733772,"0.519,0.545","0.507,0.637",-0.04]
[8899,"ENSG00000256269.8","HMBS","chr11","+",119088174,119088308,119088634,119088707,119087982,119088078,119089081,119089131,8899,"11,3",540515,"1,6",339380,283,222,0.896668107155,0.996876239279288,"0.016,0.005","0.002,0.012",0.004]
[8947,"ENSG00000151725.11","CENPU","chr4","-",184702362,184702441,184710071,184710180,184702088,184702136,184712943,184713013,8947,873857,605508,444410,"47,29",258,228,0,0,"0.56,0.599","0.893,0.926",-0.33]
[8981,"ENSG00000068878.14","PSME4","chr2","-",53866746,53866880,53869375,53869538,53866084,53866223,53875626,53875755,8981,"7,6",978837,"58,55",725714,298,283,0,0,"0.007,0.007","0.071,0.068",-0.062]
[9043,"ENSG00000172113.9","NME6","chr3","-",48296726,48296829,48298426,48298523,48296118,48296158,48301295,48301358,9043,"24,27","98,98","2,19","2,12",246,252,{"v":2.55779534609e-05,"d":"2.56E-05"},0.000157067788005728,"0.201,0.22","0.506,0.619",-0.352]
[9120,"ENSG00000124783.13","SSR1","chr6","-",7289867,7289931,7295391,7295485,7268305,7269154,7297922,7298001,9120,798717,"6,6",513448,"9,11",243,213,0.0159111411519,0.0465625723550457,"0.991,0.991","0.98,0.973",0.015]
[9141,"ENSG00000060971.17","ACAA1","chr3","-",38126161,38126700,38127785,38127866,38125825,38125881,38129289,38129388,9141,351318,518472,132137,116144,230,298,0.00242177591518,0.00925580592586824,"0.468,0.466","0.596,0.552",-0.107]
[9200,"ENSG00000268043.7","NBPF12","chr1","+",146951813,146952037,146959858,146960006,146951347,146951489,146960108,146960318,9200,"2,7","2,0","4,11","1,0",298,297,0.532821359079,0.72007476946626,"0.499,1.0","0.799,1.0",-0.15]
[9223,"ENSG00000146263.11","MMS22L","chr6","-",97270106,97270283,97272974,97273062,97269901,97269992,97278848,97278898,9223,"93,82","4,13",94120,"21,29",237,298,0.0025636297009,0.00971041735494303,"0.967,0.888","0.849,0.839",0.084]
[9273,"ENSG00000010671.15","BTK","chrX","-",101358309,101358437,101358616,101358696,101357508,101357583,101359292,101359347,9273,1151933,17301612,838766,11921252,229,277,0.617061777585,0.790961325834751,"0.446,0.412","0.46,0.425",-0.014]
[9302,"ENSG00000163466.15","ARPC2","chr2","+",218225919,218225954,218234351,218234397,218217209,218217544,218238663,218238850,9302,487543,14101388,391513,782842,184,195,0.000355584030386,1.68770967020342E-3,"0.268,0.293","0.346,0.392",-0.089]
[9371,"ENSG00000123636.17","BAZ2B","chr2","-",159453612,159453801,159478574,159478721,159448241,159448403,159555822,159555865,9371,"39,45","4,2","69,63","8,9",296,298,0.134973603957,0.266098263342092,"0.908,0.958","0.897,0.876",0.046]
[9404,"ENSG00000135655.15","USP15","chr12","+",62302789,62302920,62314789,62314916,62294178,62294306,62321463,62321489,9404,1012810,13061296,15621457,18091777,280,276,0.0792285989175,0.174922608733153,"0.433,0.381","0.46,0.447",-0.046]
[9458,"ENSG00000136643.11","RPS6KC1","chr1","+",213176399,213176492,213240701,213242297,213167857,213167973,213242568,213242658,9458,124121,185133,"99,94",161155,242,298,0.149380809224,0.28805677938128,"0.452,0.528","0.431,0.428",0.06]
[9521,"ENSG00000166169.16","POLL","chr10","-",101582762,101582891,101583507,101583681,101580247,101580416,101587245,101587406,9521,"0,2",99128,"0,0","29,27",298,278,1,1,"0.0,0.014","0.0,0.0",0.007]
[9537,"ENSG00000078369.17","GNB1","chr1","-",1817836,1817875,1825396,1825499,1815755,1815862,1839189,1839238,9537,9761122,509491,722825,436456,252,188,0.0994464791052,0.209670914799168,"0.589,0.63","0.553,0.574",0.046]
[9602,"ENSG00000165097.14","KDM1B","chr6","+",18162834,18162924,18166266,18166378,18161326,18161454,18171362,18171479,9602,198168,190176,134119,159194,239,261,0.0359148685575,0.0920569451994601,"0.532,0.51","0.479,0.401",0.081]
[9665,"ENSG00000112081.16","SRSF3","chr6","+",36599820,36600276,36601151,36601190,36598848,36598983,36601707,36601794,9665,114131,77947546,200193,85219380,298,188,0.0203768614787,0.0574896660679194,"0.009,0.011","0.015,0.013",-0.004]
[9687,"ENSG00000076258.9","FMO4","chr1","+",171319817,171319957,171334410,171334763,171316185,171316327,171337355,171337425,9687,"31,11","7,15","8,0","13,7",289,298,0.0137553846195,0.0410942344123847,"0.82,0.431","0.388,0.0",0.431]
[9724,"ENSG00000117543.20","DPH5","chr1","-",101001466,101001587,101021640,101021765,100995109,100995149,101025308,101025351,9724,398339,426333,155161,124191,274,270,0.783763115157,0.919908689513568,"0.479,0.501","0.552,0.454",-0.013]
[9772,"ENSG00000117620.14","SLC35A3","chr1","+",99999260,99999415,100007033,100007156,99993536,99993741,100011364,100011533,9772,120159,123132,145174,123135,298,272,0.425262385969,0.617701244446147,"0.471,0.524","0.518,0.541",-0.032]
[9837,"ENSG00000178105.10","DDX10","chr11","+",108852152,108852209,108917872,108918018,108841314,108841476,108940245,108940918,9837,"82,78",841732,172207,869766,206,295,{"v":3.92990395781e-09,"d":"3.93E-09"},{"v":4.25902755293949e-08,"d":"4.26E-08"},"0.123,0.132","0.221,0.279",-0.122]
[9853,"ENSG00000105229.6","PIAS4","chr19","+",4028719,4028848,4028930,4029036,4028509,4028600,4033099,4033173,9853,265242,140141,281365,204178,278,255,0.662814040921,0.828551975976712,"0.635,0.612","0.558,0.653",0.018]
[9918,"ENSG00000158793.13","NIT1","chr1","+",161119492,161119612,161119818,161119952,161119133,161119388,161120106,161120232,9918,"1,0",228234,"4,2",100109,269,283,0.257000226501,0.432764068228567,"0.005,0.0","0.04,0.019",-0.027]
[9993,"ENSG00000132780.16","NASP","chr1","+",45613168,45613248,45614095,45614181,45606481,45606591,45614292,45614366,9993,23502243,22932161,11501205,14631521,229,235,0.0115041174111,0.0352545027427722,"0.513,0.516","0.446,0.448",0.067]
[10036,"ENSG00000106991.13","ENG","chr9","-",127829686,127829827,127843093,127843245,127826509,127826672,127854288,127854636,10036,327368,307344,229236,223254,298,290,0.49498431749,0.682794687886024,"0.509,0.51","0.5,0.475",0.022]
[10078,"ENSG00000258881.6","AC007040.2","chr2","-",70989748,70989816,70991829,70991983,70988914,70989017,70993695,70993775,10078,442387,356339,165194,146221,298,217,0.160462851087,0.304128199162699,"0.475,0.454","0.451,0.39",0.044]
[10095,"ENSG00000120948.17","TARDBP","chr1","+",11015523,11015646,11016122,11016254,11013715,11013965,11016843,11017007,10095,"15,17","22,37","9,4","2,1",272,281,0.000180670143943,0.000919265730130268,"0.413,0.322","0.823,0.805",-0.447]
[10167,"ENSG00000175931.12","UBE2O","chr17","-",76391755,76391813,76391909,76392113,76389450,76391613,76395724,76395861,10167,481470,139146,430390,148156,298,207,0.121707910039,0.245348558286945,"0.706,0.691","0.669,0.635",0.046]
[10178,"ENSG00000180198.16","RCC1","chr1","+",28535257,28535380,28535870,28536026,28535049,28535146,28536261,28536293,10178,14891791,20732072,10061131,11631314,272,298,0.39995535083,0.591456942069189,"0.44,0.486","0.487,0.485",-0.023]
[10241,"ENSG00000118308.15","LRMP","chr12","+",25062819,25062900,25063719,25063816,25061591,25061653,25066364,25066409,10241,"28,26",182148,"7,13","68,59",230,246,0.76265795657,0.904760381529637,"0.141,0.158","0.099,0.191",0.004]
[10301,"ENSG00000055208.18","TAB2","chr6","+",149397968,149398062,149399103,149399184,149397603,149397764,149409576,149411382,10301,249233,249216,327236,326336,243,230,0.161095035769,0.305043347268975,"0.486,0.505","0.487,0.399",0.052]
[10328,"ENSG00000213064.9","SFT2D2","chr1","+",168231833,168231919,168235100,168235182,168231513,168231600,168236588,168236624,10328,184170,"90,99","105,68","75,62",235,231,0.0239970145804,0.0659558312669122,"0.668,0.628","0.579,0.519",0.099]
[10396,"ENSG00000138380.17","CARF","chr2","+",202941859,202941980,202942739,202942967,202917876,202918043,202952558,202952679,10396,"26,29","38,46","19,22","40,65",270,298,0.0568166022058,0.133536844661309,"0.43,0.41","0.344,0.272",0.112]
[10417,"ENSG00000057019.15","DCBLD2","chr3","-",98849460,98849598,98881539,98881767,98825314,98825366,98901121,98901326,10417,"87,75","72,70",118107,"22,28",298,287,{"v":5.45415934639e-11,"d":"5.45E-11"},{"v":7.43174689836488e-10,"d":"7.43E-10"},"0.538,0.508","0.838,0.786",-0.289]
[10488,"ENSG00000112249.13","ASCC3","chr6","-",100848147,100848707,100864063,100864214,100805759,100805880,100867907,100868038,10488,442476,321251,267216,189136,298,298,0.591726588647,0.769772158424585,"0.579,0.655","0.586,0.614",0.017]
[10540,"ENSG00000144306.14","SCRN3","chr2","+",174404102,174404315,174422884,174423047,174400989,174401189,174424474,174424570,10540,244195,262201,217187,107100,298,298,{"v":8.7789146852e-07,"d":"8.78E-07"},{"v":6.92360245917019e-06,"d":"6.92E-06"},"0.482,0.492","0.67,0.652",-0.174]
[10562,"ENSG00000137770.13","CTDSPL2","chr15","+",44514597,44514660,44519168,44519295,44499726,44499813,44521310,44521406,10562,130145,362339,"55,59",176179,212,276,0.206896414437,0.368130893045539,"0.319,0.358","0.289,0.3",0.044]
[10677,"ENSG00000197329.11","PELI1","chr2","-",64104700,64104830,64108239,64108379,64100397,64100499,64144080,64144454,10677,"49,63","68,98",136126,"62,46",289,279,{"v":2.20334861467E-11,"d":"2.20E-11"},{"v":3.1553244119197e-10,"d":"3.16E-10"},"0.41,0.383","0.679,0.726",-0.306]
[10704,"ENSG00000172456.17","FGGY","chr1","+",59378748,59378837,59456960,59457076,59321535,59321750,59512310,59512439,10704,"1,0","45,46","4,1","28,19",238,265,0.0104000221882,0.032356424611834,"0.024,0.0","0.137,0.055",-0.084]
[10768,"ENSG00000145241.10","CENPC","chr4","-",67492179,67492275,67492868,67492997,67489966,67490121,67493883,67493988,10768,304258,188127,245246,150154,278,245,0.454362713635,0.645587811770564,"0.588,0.642","0.59,0.585",0.028]
[10812,"ENSG00000116133.12","DHCR24","chr1","-",54879059,54879319,54879748,54879805,54875941,54876047,54883617,54883773,10812,"12,12","9,0","0,1","2,0",206,298,0.679936521652,0.841609055467062,"0.659,1.0","0.0,1.0",0.33]
[10855,"ENSG00000198270.12","TMEM116","chr12","-",111938160,111938210,111943264,111943369,111933885,111934030,111991757,111991889,10855,"16,6","0,0","0,5","1,6",254,199,{"v":4.34478410138E-7,"d":"4.34E-07"},{"v":3.56288153189442E-6,"d":"3.56E-06"},"1.0,1.0","0.0,0.395",0.802]
[10917,"ENSG00000087842.10","PIR","chrX","-",15407505,15407550,15425905,15425990,15397448,15397531,15455847,15456054,10917,136108,"48,31","56,49","36,23",234,194,0.020157574203,0.0569783035309104,"0.701,0.743","0.563,0.639",0.121]
[10940,"ENSG00000072274.12","TFRC","chr3","-",196060179,196060247,196062581,196062645,196058573,196058632,196062853,196062939,10940,30212771,50374392,21201947,27142832,213,217,0.0911799052818,0.195643128257367,"0.379,0.391","0.443,0.412",-0.042]
[11011,"ENSG00000134242.15","PTPN22","chr1","-",113854470,113854537,113858477,113858573,113852026,113852104,113859001,113859078,11011,"64,75","37,23","82,79","43,33",245,216,0.709961448256,0.865082634537096,"0.604,0.742","0.627,0.679",0.02]
[11031,"ENSG00000145391.13","SETD7","chr4","-",139533164,139533366,139546919,139547049,139529030,139529220,139556097,139556238,11031,"56,65","73,72","51,51","98,78",279,298,0.0699674611183,0.158142931683641,"0.45,0.491","0.357,0.411",0.087]
[11099,"ENSG00000124721.17","DNAH8","chr6","+",38750475,38750589,38755971,38756079,38741710,38741887,38761701,38761803,11099,"1,5","1,3","5,12","6,1",263,257,0.821616278839,0.94579108403266,"0.494,0.62","0.449,0.921",-0.128]
[11141,"ENSG00000134058.11","CDK7","chr5","+",69258042,69258153,69259817,69259936,69255459,69255528,69262204,69262304,11141,179175,213198,204223,290255,260,268,0.500231953013,0.688159661559364,"0.464,0.477","0.42,0.474",0.024]
[11181,"ENSG00000256861.1","AC048338.1","chr12","-",122232799,122232968,122238586,122238724,122232325,122232427,122239877,122239945,11181,308252,410339,176185,207177,287,298,0.0899492630575,0.193403826951097,"0.438,0.436","0.469,0.52",-0.057]
[11251,"ENSG00000160214.12","RRP1","chr21","+",43800861,43800881,43802273,43802387,43800516,43800614,43803511,43805293,11251,239222,320320,142143,292276,169,263,0.00858822395278,0.0275709107008163,"0.538,0.519","0.431,0.446",0.09]
[11274,"ENSG00000071054.16","MAP4K4","chr2","+",101835899,101835978,101839818,101839994,101834408,101834463,101842608,101842681,11274,611582,743694,412422,611566,228,298,0.175316374434,0.325095619143149,"0.518,0.523","0.468,0.494",0.039]
[11332,"ENSG00000096401.7","CDC5L","chr6","+",44426102,44426183,44429712,44429910,44424418,44424583,44445654,44445867,11332,303230,547388,421395,695814,230,298,0.663209410458,0.828847676692551,"0.418,0.434","0.44,0.386",0.013]
[11357,"ENSG00000166704.11","ZNF606","chr19","-",58000682,58000739,58001288,58001370,57988675,57988721,58002395,58002782,11357,"16,27","5,1","60,39","1,1",231,206,0.00791275838356,0.0257184678316519,"0.741,0.96","0.982,0.972",-0.126]
[11411,"ENSG00000112715.21","VEGFA","chr6","+",43778459,43778536,43782010,43782087,43777468,43777665,43784540,43784562,11411,144163,235179,86140,"52,42",226,226,{"v":1.66785536149E-6,"d":"1.67E-06"},{"v":1.25208961300764E-5,"d":"1.25E-05"},"0.38,0.477","0.623,0.769",-0.267]
[11442,"ENSG00000215788.10","TNFRSF25","chr1","-",6462628,6462666,6462862,6462970,6461993,6462174,6464374,6464453,11442,"14,25",155209,"7,7",66103,257,187,0.342893181482,0.53211319115402,"0.062,0.08","0.072,0.047",0.012]
[11515,"ENSG00000031823.14","RANBP3","chr19","-",5923811,5923914,5924826,5924905,5923193,5923303,5925633,5925737,11515,449445,370302,321322,245297,228,252,0.364730789734,0.55526364350791,"0.573,0.62","0.592,0.545",0.028]
[11558,"ENSG00000109919.9","MTCH2","chr11","-",47622700,47622776,47625673,47625741,47617315,47618919,47627079,47627127,11558,523490,729640,129109,138150,217,225,0.442153682794,0.633461785945739,"0.427,0.443","0.492,0.43",-0.026]
[11606,"ENSG00000204410.14","MSH5","chr6","+",31743107,31743170,31743903,31744025,31742876,31742957,31744189,31744234,11606,148140,170110,"62,70","50,61",212,271,0.492611715495,0.680719104271657,"0.527,0.619","0.613,0.595",-0.031]
[11667,"ENSG00000128908.16","INO80","chr15","-",41005592,41005687,41016087,41016215,40997528,40997601,41020899,41021125,11667,143141,148137,115132,157181,277,244,0.0444878212234,0.109305287596344,"0.46,0.476","0.392,0.391",0.076]
[11702,"ENSG00000047365.11","ARAP2","chr4","-",36150899,36151044,36158729,36158864,36148404,36148507,36159330,36159505,11702,"1,5","7,8","2,2","7,22",284,294,0.176088060282,0.326257328809784,"0.129,0.393","0.228,0.086",0.104]
[11749,"ENSG00000097096.8","SYDE2","chr1","-",85178145,85178272,85182097,85183200,85169043,85169225,85190056,85190752,11749,"49,38","5,8","16,16","2,4",298,276,0.852453072503,0.967753035876612,"0.901,0.815","0.881,0.787",0.024]
[11814,"ENSG00000175567.8","UCP2","chr11","-",73976822,73977017,73977885,73978096,73976640,73976742,73978252,73978477,11814,743810,18621841,"120,86",155168,298,298,0.0110431029752,0.0339900658561327,"0.285,0.306","0.436,0.339",-0.092]
[11837,"ENSG00000058804.11","NDC1","chr1","-",53772328,53772489,53800692,53800848,53765459,53768033,53803927,53804009,11837,12361171,791626,249256,182188,298,298,0.0770550528237,0.171014419389146,"0.61,0.652","0.578,0.577",0.054]
[11881,"ENSG00000115232.13","ITGA4","chr2","+",181478756,181478824,181480136,181480266,181475158,181475288,181481597,181481683,11881,13731230,36653223,709601,457447,217,279,0,0,"0.325,0.329","0.666,0.634",-0.323]
[11923,"ENSG00000180902.17","D2HGDH","chr2","+",241744708,241744877,241755848,241756014,241743621,241743815,241767709,241768809,11923,110124,"66,74","27,38","27,24",298,298,0.299786555633,0.483762145828632,"0.625,0.626","0.5,0.613",0.069]
[11996,"ENSG00000225921.6","NOL7","chr6","+",13617769,13617801,13618057,13618139,13616462,13616521,13620207,13620329,11996,126124,11651133,130128,819808,181,231,6.26664477235E-3,0.0210000360014813,"0.121,0.123","0.168,0.168",-0.046]
[12015,"ENSG00000118454.12","ANKRD13C","chr1","-",70270855,70270956,70274719,70274818,70260587,70262847,70276764,70276844,12015,146122,"119,88","56,73",112126,248,250,{"v":3.93144798716e-07,"d":"3.93E-07"},{"v":3.2524191761229e-06,"d":"3.25E-06"},"0.553,0.583","0.335,0.369",0.216]
[12081,"ENSG00000242588.6","AC108010.1","chr7","+",128609486,128609579,128615859,128615970,128608117,128608213,128617867,128617977,12081,79110,112155,"73,59",158109,242,260,0.040229858513,0.101008458032025,"0.431,0.433","0.332,0.368",0.082]
[12152,"ENSG00000275052.4","PPP4R3B","chr2","-",55573618,55573777,55577314,55577356,55568193,55568363,55579678,55579781,12152,"62,95",459471,230252,189185,191,298,0,0,"0.174,0.239","0.655,0.68",-0.461]
[12208,"ENSG00000255717.6","SNHG1","chr11","-",62853800,62853833,62854518,62854551,62853551,62853590,62855132,62855216,12208,"71,90",735588,16631564,23682471,182,182,0,0,"0.088,0.133","0.413,0.388",-0.29]
[12243,"ENSG00000029364.11","SLC39A9","chr14","+",69424093,69424202,69453240,69453309,69398689,69399465,69454811,69454897,12243,89117,"85,77",175207,89133,258,218,0.0885818631676,0.191121235620188,"0.469,0.562","0.624,0.568",-0.08]
[12260,"ENSG00000061273.17","HDAC7","chr12","-",47796206,47796298,47797016,47797142,47795586,47795767,47797383,47797499,12260,793936,"90,88",730688,242263,275,241,0,0,"0.885,0.903","0.726,0.696",0.183]
[12312,"ENSG00000132128.16","LRRC41","chr1","-",46279181,46279257,46280191,46280290,46267494,46267677,46280395,46280560,12312,301300,"1,1","21,39","1,0",248,225,1,1,"0.996,0.996","0.95,1.0",0.021]
[12346,"ENSG00000132781.17","MUTYH","chr1","-",45330515,45330557,45331419,45331556,45329162,45329437,45332762,45332834,12346,"0,0",230219,"4,3","89,92",286,191,0.268259143107,0.446341017335326,"0.0,0.0","0.029,0.021",-0.025]
[12411,"ENSG00000176393.10","RNPEP","chr1","+",201989382,201989531,201996146,201996409,201988903,201989044,201997318,201997554,12411,509451,"42,25","73,70","65,50",298,298,0,0,"0.924,0.947","0.529,0.583",0.379]
[12476,"ENSG00000115841.19","RMDN2","chr2","+",37975211,37975314,37981282,37981343,37974039,37974214,37989540,37989616,12476,"48,50","14,18","70,75","35,37",252,210,0.0983841621645,0.207879794966536,"0.741,0.698","0.625,0.628",0.093]
[12529,"ENSG00000177479.19","ARIH2","chr3","+",48945135,48945181,48961611,48961679,48927461,48927813,48967124,48967275,12529,"11,17",249250,"16,10",315406,195,217,0.148009691015,0.285790216591688,"0.047,0.07","0.054,0.027",0.018]
[12564,"ENSG00000145860.11","RNF145","chr5","-",159194715,159194824,159203433,159203656,159181959,159182051,159209852,159210053,12564,"0,5",329303,"1,0",210176,298,258,1,1,"0.0,0.014","0.004,0.0",0.005]
[12585,"ENSG00000170113.15","NIPA1","chr15","+",22812162,22812253,22820312,22820473,22810748,22810796,22823727,22823771,12585,"22,13","72,96","10,15",106108,240,298,0.0649749785763,0.148926124006006,"0.275,0.144","0.105,0.147",0.084]
[12661,"ENSG00000204623.9","ZNRD1ASP","chr6","-",30021666,30021761,30034907,30035110,30001010,30002732,30058114,30058190,12661,"0,0","14,15","1,2","1,5",298,244,0.0610076907736,0.141419767253896,"0.0,0.0","0.45,0.247",-0.349]
[12714,"ENSG00000143493.12","INTS7","chr1","-",211975165,211975372,211976581,211976719,211968512,211968707,211978271,211978511,12714,301335,500450,355402,414471,287,298,0.0459895563581,0.112307286361281,"0.385,0.436","0.471,0.47",-0.06]
[12731,"ENSG00000142657.20","PGD","chr1","+",10403070,10403136,10408070,10408140,10400392,10400572,10411417,10411552,12731,37933544,11931149,24952494,13321388,215,219,{"v":4.0547666158E-7,"d":"4.05E-07"},{"v":3.3421332021427e-06,"d":"3.34E-06"},"0.764,0.759","0.656,0.647",0.11]
[12789,"ENSG00000100084.14","HIRA","chr22","-",19351357,19351446,19359335,19359484,19330697,19331556,19361236,19361341,12789,324351,259226,187196,"106,88",298,238,0.0156628795473,0.0459737740755432,"0.5,0.554","0.585,0.64",-0.086]
[12812,"ENSG00000164144.15","ARFIP1","chr4","+",152863605,152863714,152888132,152888307,152829624,152829726,152910063,152910244,12812,105139,265197,"102,90",178153,258,298,0.660730838639,0.827303494755067,"0.314,0.449","0.398,0.405",-0.02]
[12875,"ENSG00000117448.13","AKR1A1","chr1","+",45561788,45561878,45566568,45566688,45552435,45552563,45566868,45567020,12875,174173,792869,"29,24",319372,239,269,{"v":6.02727545651E-9,"d":"6.03E-09"},{"v":6.38805906756241e-08,"d":"6.39E-08"},"0.198,0.183","0.093,0.068",0.11]
[12918,"ENSG00000115761.15","NOL10","chr2","-",10644319,10644372,10654480,10654547,10607184,10607311,10657741,10657891,12918,333270,270242,"94,56","82,92",216,202,0.140482904129,0.274383725041246,"0.536,0.511","0.517,0.363",0.084]
[12959,"ENSG00000184182.18","UBE2F","chr2","+",237994743,237994809,238025341,238025412,237973094,237973225,238030555,238030613,12959,"3,1",186167,"8,3",221301,215,220,0.184390498303,0.338071816105271,"0.016,0.006","0.036,0.01",-0.012]
[13020,"ENSG00000198400.11","NTRK1","chr1","+",156868103,156868249,156868504,156868647,156866909,156866978,156871622,156871755,13020,169197,104113,"18,11","20,13",295,292,0.024090853897,0.0661651871668125,"0.617,0.633","0.471,0.456",0.161]
[13063,"ENSG00000160124.9","CCDC58","chr3","-",122362967,122363027,122368175,122368322,122359590,122359919,122371674,122371800,13063,12611204,"15,4",833911,"6,7",296,209,0.808415023804,0.936302946899591,"0.983,0.995","0.99,0.989",-1E-3]
[13102,"ENSG00000198198.16","SZT2","chr1","+",43435199,43435329,43437170,43437323,43432988,43434485,43437405,43437508,13102,"76,86",119129,"61,78","84,80",279,298,0.166996441779,0.313365880268277,"0.406,0.416","0.437,0.51",-0.062]
[13119,"ENSG00000114388.12","NPRL2","chr3","-",50349385,50349494,50349664,50349833,50348684,50348782,50349930,50350022,13119,207201,"2,2","76,92","0,0",298,258,1,1,"0.989,0.989","1.0,1.0",-0.011]
[13187,"ENSG00000187109.13","NAP1L1","chr12","-",76049199,76049250,76049755,76049785,76036586,76048464,76050530,76050653,13187,20301788,954944,17531839,948872,179,200,0.879389477735,0.984995123391212,"0.704,0.679","0.674,0.702",0.004]
[13229,"ENSG00000163374.19","YY1AP1","chr1","-",155668626,155668777,155675009,155675096,155660716,155661423,155676547,155676746,13229,283314,317280,309242,286240,236,298,0.737404280594,0.885555145946904,"0.53,0.586","0.577,0.56",-0.01]
[13268,"ENSG00000125835.18","SNRPB","chr20","-",2465707,2465819,2467606,2467758,2463746,2463899,2470687,2470732,13268,67916245,32423407,78518655,41154543,298,261,0.791224369078,0.925005125377696,"0.647,0.616","0.626,0.625",0.006]
[13333,"ENSG00000123473.15","STIL","chr1","-",47289434,47289585,47293457,47293544,47287550,47287660,47295764,47295848,13333,200183,259257,258223,423475,236,298,0.0144195827832,0.0427565283059714,"0.494,0.473","0.435,0.372",0.08]
[13360,"ENSG00000129493.14","HEATR5A","chr14","-",31295908,31296063,31306731,31306879,31293890,31294104,31307892,31308020,13360,"34,42","66,60","22,10","14,21",297,298,0.384123127355,0.575346403341509,"0.341,0.413","0.612,0.323",-0.091]
[13416,"ENSG00000148429.14","USP6NL","chr10","-",11481769,11481922,11484970,11485070,11453945,11463849,11485168,11485234,13416,111128,119107,123125,105139,249,298,0.830472442881,0.952229297769605,"0.527,0.589","0.584,0.518",0.007]
[13435,"ENSG00000143727.15","ACP1","chr2","+",272036,272150,276979,277085,271865,271939,277226,277261,13435,10161025,15581385,12671514,11051186,263,255,{"v":2.59181816009e-07,"d":"2.59E-07"},{"v":2.20338865830731E-6,"d":"2.20E-06"},"0.387,0.418","0.526,0.553",-0.137]
[13489,"ENSG00000114786.16","ABHD14A-ACY1","chr3","+",51984060,51984158,51985360,51985465,51978258,51978374,51985851,51985946,13489,"3,0",235212,"6,6","65,93",247,254,{"v":5.87044841657e-05,"d":"5.87E-05"},3.33004558121462E-4,"0.013,0.0","0.087,0.062",-0.068]
[13565,"ENSG00000113194.12","FAF2","chr5","+",176488950,176489027,176492193,176492332,176486354,176486489,176493998,176494084,13565,"115,98",133124,153134,125138,226,288,0.0855926003951,0.185850419238258,"0.524,0.502","0.609,0.553",-0.068]
[13582,"ENSG00000137522.17","RNF121","chr11","+",71990596,71990717,71994718,71994852,71960749,71960891,71995449,71995551,13582,"14,19",141158,107107,198221,270,283,{"v":8.04911692853e-14,"d":"8.05E-14"},{"v":1.46086921055848E-12,"d":"1.46E-12"},"0.094,0.112","0.362,0.337",-0.247]
[13637,"ENSG00000164506.14","STXBP5","chr6","+",147314263,147314331,147314595,147314636,147313883,147314031,147315514,147315735,13637,12121155,338328,555458,659671,217,190,0,0,"0.758,0.755","0.424,0.374",0.357]
[13666,"ENSG00000118007.12","STAG1","chr3","-",136521212,136521417,136568764,136568861,136502627,136502779,136604308,136604473,13666,"42,26",200151,"29,47",153194,246,298,0.555336456073,0.739384619074676,"0.203,0.173","0.187,0.227",-0.019]
[13732,"ENSG00000135040.15","NAA35","chr9","+",85996398,85996577,86003584,86003644,85978266,85978381,86007357,86007464,13732,127152,141167,176219,157146,298,209,0.0198541302901,0.0562763281806808,"0.387,0.39","0.44,0.513",-0.088]
[13753,"ENSG00000115760.14","BIRC6","chr2","+",32471013,32471151,32473111,32473239,32470167,32470301,32476212,32476344,13753,280248,263240,207184,220166,287,277,0.822933232785,0.946579646127068,"0.507,0.499","0.476,0.517",0.007]
[13812,"ENSG00000143537.13","ADAM15","chr1","+",155055786,155055852,155055931,155056000,155054313,155054506,155056079,155056249,13812,"9,8",328370,"2,6",181180,215,218,0.614076531535,0.788033901825342,"0.027,0.021","0.011,0.033",2E-3]
[13888,"ENSG00000138032.20","PPM1B","chr2","+",44209209,44209327,44217966,44218078,44168909,44169274,44218479,44218537,13888,"0,8",399290,"7,12",489466,267,261,0.152546391219,0.292604137297226,"0.0,0.026","0.014,0.025",-0.007]
[13907,"ENSG00000250565.6","ATP6V1E2","chr2","-",46536610,46536703,46541389,46541453,46535812,46535927,46541675,46542178,13907,"1,2","18,7","1,0","19,19",213,242,0.230436411127,0.398405334072988,"0.059,0.245","0.056,0.0",0.124]
[13945,"ENSG00000162869.15","PPP1R21","chr2","+",48498492,48498735,48505563,48505596,48495678,48495771,48507268,48507385,13945,135117,"33,13",160144,"10,13",298,182,4.99651882248E-3,0.0173438562370312,"0.714,0.846","0.907,0.871",-0.109]
[13989,"ENSG00000214021.15","TTLL3","chr3","+",9816073,9816202,9818821,9818920,9813247,9813345,9820545,9820741,13989,153182,"6,16",219238,"74,82",278,248,{"v":3.9312997302e-13,"d":"3.93E-13"},{"v":6.65153415947769e-12,"d":"6.65E-12"},"0.958,0.91","0.725,0.721",0.211]
[14052,"ENSG00000138758.11","2024-09-11","chr4","+",76996424,76996539,77005600,77005796,76949702,76949930,77011734,77011921,14052,246339,12281109,228199,643709,264,298,0.0664872933654,0.151711485186064,"0.184,0.257","0.286,0.241",-0.043]
[14074,"ENSG00000113761.11","ZNF346","chr5","+",177044388,177044533,177050750,177050936,177041777,177041870,177062057,177062151,14074,173203,107122,"81,45","71,57",294,298,0.00730783160739,0.0239987822839003,"0.621,0.628","0.536,0.445",0.134]
[14135,"ENSG00000162384.13","C1orf123","chr1","-",53218413,53218495,53218866,53218923,53218171,53218203,53220260,53220344,14135,"152,86",726718,"13,30",214189,206,231,0.0335968677166,0.0870288241554398,"0.19,0.118","0.064,0.151",0.046]
[14200,"ENSG00000168538.15","TRAPPC11","chr4","+",183685270,183685403,183686617,183686748,183685083,183685145,183691315,183691471,14200,297255,275211,205160,164214,282,280,0.376548759419,0.567296956630705,"0.517,0.545","0.554,0.426",0.041]
[14226,"ENSG00000115307.16","AUP1","chr2","-",74527247,74527363,74527470,74527590,74526940,74527059,74527735,74527838,14226,20051998,24242308,21802073,21942218,269,265,0.214593609222,0.378475853888047,"0.449,0.46","0.495,0.479",-0.032]
[14309,"ENSG00000087338.4","GMCL1","chr2","+",69843148,69843261,69844130,69844196,69840941,69841039,69847542,69847627,14309,536404,146180,117151,"56,37",262,215,0.948542523411,1,"0.751,0.648","0.632,0.77",-2E-3]
[14343,"ENSG00000179818.13","PCBP1-AS1","chr2","-",70015447,70015580,70018014,70018131,70011654,70011718,70051202,70051305,14343,"18,9","0,1","15,11","0,0",266,282,1,1,"1.0,0.905","1.0,1.0",-0.047]
[14414,"ENSG00000106635.7","BCL7B","chr7","-",73543547,73543644,73552166,73552242,73537933,73538013,73557486,73557671,14414,138217,"23,13",101121,"2,3",225,246,{"v":7.39751381633e-05,"d":"7.40E-05"},0.000409496767526776,"0.868,0.948","0.982,0.978",-0.072]
[14439,"ENSG00000104980.7","TIMM44","chr19","-",7931137,7931188,7932626,7932751,7928076,7928166,7932839,7932932,14439,632523,199200,422428,120125,274,200,0.173018536345,0.321977264629435,"0.699,0.656","0.72,0.714",-0.039]
[14506,"ENSG00000134910.13","STT3A","chr11","+",125609433,125609589,125612591,125612747,125608108,125608289,125612988,125613177,14506,21992165,22871869,864866,834876,298,298,0.702616833775,0.860004229345234,"0.49,0.537","0.509,0.497",0.011]
[14578,"ENSG00000143515.16","ATP8B2","chr1","+",154345321,154345545,154345799,154345883,154344970,154345154,154346230,154346476,14578,185158,81109,103112,"48,60",298,233,0.630092078537,0.802399620984348,"0.641,0.531","0.627,0.593",-0.024]
[14627,"ENSG00000115827.13","DCAF17","chr2","+",171468887,171469030,171473865,171473975,171453123,171453213,171476859,171476950,14627,"53,41",156157,139142,"47,50",292,259,0,0,"0.232,0.188","0.724,0.716",-0.51]
[14659,"ENSG00000173692.12","PSMD1","chr2","+",231163634,231163727,231165199,231165286,231161339,231161509,231165870,231166017,14659,1023883,13051080,661709,13411182,242,236,0.000434454182228,0.00202399979690668,"0.433,0.444","0.325,0.369",0.092]
[14676,"ENSG00000124155.17","PIGT","chr20","+",45418851,45418979,45419503,45419590,45416140,45416343,45420331,45420429,14676,"1,4","4,3","1,0","39,50",277,236,0.000284022525264,1.38012589103737E-3,"0.176,0.532","0.021,0.0",0.343]
[14757,"ENSG00000126070.19","AGO3","chr1","+",35973374,35973511,36004340,36004475,35972023,35972232,36008896,36009044,14757,195180,"0,3",113112,"59,49",286,284,0,0,"1.0,0.983","0.655,0.694",0.317]
[14805,"ENSG00000130414.11","NDUFA10","chr2","-",239990073,239990182,240011616,240014860,239960740,239961186,240018552,240018639,14805,894813,463561,496510,350315,298,258,0.424087612497,0.616552867369465,"0.626,0.556","0.551,0.584",0.023]
[14823,"ENSG00000075568.16","TMEM131","chr2","-",97772296,97772424,97792385,97792984,97766477,97766602,97793394,97793553,14823,177134,236245,"53,59",102102,298,277,0.348562644048,0.538271755952887,"0.411,0.337","0.326,0.35",0.036]
[14857,"ENSG00000163946.13","FAM208A","chr3","-",56666259,56666384,56668396,56668558,56663540,56663572,56669699,56669791,14857,130101,156161,"35,41","89,69",298,274,0.0411739894997,0.10291894204792,"0.434,0.366","0.266,0.353",0.091]
[14910,"ENSG00000163006.11","CCDC138","chr2","+",108856793,108856970,108873450,108873589,108846737,108846930,108876087,108876578,14910,127134,160154,"96,76","31,14",298,288,{"v":5.6943338933e-13,"d":"5.69E-13"},{"v":9.49154215493751e-12,"d":"9.49E-12"},"0.434,0.457","0.75,0.84",-0.349]
[14971,"ENSG00000079156.16","OSBPL6","chr2","+",178336300,178336433,178338990,178339094,178332870,178333041,178349223,178349389,14971,382372,263254,575505,370374,282,253,0.960837238665,1,"0.566,0.568","0.582,0.548",2E-3]
[15038,"ENSG00000119688.20","ABCD4","chr14","-",74295147,74295198,74295853,74295979,74292747,74292869,74296332,74296449,15038,"98,80","1,6","88,94","6,19",275,200,0.00238256675265,0.00914015577348349,"0.986,0.907","0.914,0.783",0.098]
[15058,"ENSG00000072182.12","ASIC4","chr2","+",219531757,219531902,219535170,219535324,219514329,219515306,219537065,219537157,15058,212170,183248,178186,288279,294,298,0.0823526172687,0.180454550166805,"0.54,0.41","0.385,0.403",0.081]
[15124,"ENSG00000100485.11","SOS2","chr14","-",50174453,50174552,50180571,50180682,50161481,50161609,50182462,50182606,15124,"128,81","86,81","66,84","82,67",260,248,0.364166006128,0.554666892061417,"0.587,0.488","0.434,0.545",0.048]
[15147,"ENSG00000143207.20","COP1","chr1","-",176135009,176135086,176149005,176149074,176116623,176116681,176175909,176176007,15147,"16,16",237184,"20,17",196116,218,226,0.0998236926864,0.210268918249809,"0.065,0.083","0.096,0.132",-0.04]
[15213,"ENSG00000117479.13","SLC19A2","chr1","-",169468643,169468737,169477154,169477757,169468110,169468252,169485562,169485941,15213,98129,111116,168134,82107,298,243,0.0183122862006,0.0525624372306184,"0.419,0.476","0.626,0.505",-0.118]
[15236,"ENSG00000156110.13","ADK","chr10","+",74224537,74224591,74314666,74314745,74200763,74200838,74394140,74394313,15236,210215,257265,"87,94",85112,203,228,0.432961497154,0.624579270491959,"0.479,0.477","0.535,0.485",-0.032]
[15299,"ENSG00000082269.16","FAM135A","chr6","+",70426438,70426532,70428303,70428419,70415290,70415376,70452491,70452571,15299,"28,30","96,83","16,15","50,56",243,265,0.666474652674,0.831735884588019,"0.241,0.283","0.259,0.226",0.02]
[15345,"ENSG00000048740.18","CELF2","chr10","+",11314138,11314270,11325835,11325979,11288417,11288552,11328925,11329097,15345,603695,464315,674678,334285,281,293,0.121270783233,0.244599033075608,"0.575,0.697","0.678,0.713",-0.06]
[15384,"ENSG00000137266.14","SLC22A23","chr6","-",3410187,3410342,3415751,3415855,3323341,3324002,3455905,3456559,15384,"21,8","97,76","3,10","33,31",253,298,0.799212731545,0.930482682849467,"0.203,0.11","0.097,0.275",-0.029]
[15460,"ENSG00000162511.7","LAPTM5","chr1","-",30739808,30739937,30741639,30741716,30738939,30739062,30742455,30742549,15460,25122752,38843864,39643867,57656062,226,278,0.814061770511,0.940164263022909,"0.443,0.467","0.458,0.44",0.006]
[15493,"ENSG00000198837.9","DENND4B","chr1","-",153936059,153936188,153936541,153936748,153934759,153934964,153937487,153937614,15493,423475,248339,384351,192198,298,278,0.118510686592,0.240196339259935,"0.614,0.567","0.651,0.623",-0.046]
[15546,"ENSG00000174501.14","ANKRD36C","chr2","-",95918013,95918042,95919891,95919920,95917854,95917927,95921606,95921679,15546,"3,10","6,7","2,2","3,1",178,178,0.967193283501,1,"0.333,0.588","0.4,0.667",-0.073]
[15563,"ENSG00000117859.18","OSBPL9","chr1","+",51750144,51750195,51756319,51756358,51748368,51748398,51760689,51760780,15563,690589,"101,98",228232,"33,27",200,188,0.287055021119,0.468870722011985,"0.865,0.85","0.867,0.89",-0.021]
[15637,"ENSG00000124523.15","SIRT5","chr6","+",13591668,13591894,13595476,13595564,13588330,13588464,13596962,13597016,15637,127135,"67,45","33,51","50,37",298,237,0.00238518834095,0.00914552846976203,"0.601,0.705","0.344,0.523",0.22]
[15692,"ENSG00000188130.13","MAPK12","chr22","-",50256787,50256964,50257081,50257193,50256598,50256646,50258242,50258301,15692,175238,116106,126159,128103,261,298,0.0400689875366,0.100672043045942,"0.633,0.719","0.529,0.638",0.092]
[15709,"ENSG00000143198.12","MGST3","chr1","+",165649754,165649964,165651013,165651087,165631238,165631293,165651977,165652035,15709,"2,5",544496,"12,32",263299,298,223,{"v":2.14934736675E-11,"d":"2.15E-11"},{"v":3.07995446323378e-10,"d":"3.08E-10"},"0.003,0.007","0.033,0.074",-0.049]
[15776,"ENSG00000084463.7","WBP11","chr12","-",14794536,14794736,14794970,14795104,14793730,14793922,14796806,14797003,15776,891670,11321133,621564,796754,283,298,0.341133376803,0.530151185737073,"0.453,0.384","0.451,0.441",-0.028]
[15806,"ENSG00000148225.15","WDR31","chr9","-",113328880,113328955,113330983,113331116,113323010,113323155,113331906,113332050,15806,"7,3","3,5","0,2","0,0",282,224,1,1,"0.65,0.323","NA,1.0",-0.513]
[15861,"ENSG00000160746.12","ANO10","chr3","-",43561219,43561402,43565652,43565727,43555277,43555469,43574808,43574864,15861,"66,74",153182,"44,55",126107,224,298,0.945511433415,1,"0.365,0.351","0.317,0.406",-0.004]
[15878,"ENSG00000131508.15","UBE2D2","chr5","+",139614585,139614617,139614696,139614774,139600371,139600435,139614860,139614966,15878,231286,982839,180169,638717,181,227,0.464003507898,0.654715826360221,"0.228,0.299","0.261,0.228",0.019]
[15937,"ENSG00000157985.18","AGAP1","chr2","+",235930764,235930923,235968461,235968623,235908737,235908906,236036560,236036715,15937,"87,94",263255,"19,25",322358,298,298,0,0,"0.249,0.269","0.056,0.065",0.199]
[16011,"ENSG00000144504.15","ANKMY1","chr2","-",240507559,240507691,240511860,240512001,240500451,240500565,240512801,240512942,16011,"7,9","24,31","10,9","8,10",290,281,0.00306477455641,0.0113916326729489,"0.22,0.22","0.548,0.466",-0.287]
[16029,"ENSG00000122085.16","MTERF4","chr2","-",241089979,241090044,241097242,241097427,241087093,241089365,241099395,241099894,16029,148127,"66,57","61,67","68,52",298,214,0.000320326651482,0.00153659682582174,"0.617,0.615","0.392,0.481",0.179]
[16072,"ENSG00000163106.10","HPGDS","chr4","-",94302145,94302244,94317872,94317965,94298534,94299644,94334496,94334638,16072,828665,594563,479570,154165,242,248,{"v":3.97459842816e-14,"d":"3.97E-14"},{"v":7.44210434019392e-13,"d":"7.44E-13"},"0.588,0.548","0.761,0.78",-0.202]
[16112,"ENSG00000117395.12","EBNA1BP2","chr1","-",43171478,43171651,43171885,43171969,43170755,43170879,43172052,43172141,16112,10201193,26562932,640751,14961709,233,298,0.395612608806,0.587276671991412,"0.329,0.342","0.354,0.36",-0.021]
[16173,"ENSG00000198520.11","ARMH1","chr1","+",44724319,44724392,44724761,44724839,44724121,44724244,44725135,44725217,16173,"32,16","14,8","22,34","11,5",222,227,0.26945225664,0.447705594501527,"0.7,0.672","0.672,0.874",-0.087]
[16216,"ENSG00000131374.14","TBC1D5","chr3","-",17238162,17238419,17258505,17258591,17214206,17214370,17291894,17292001,16216,173168,156161,121125,140182,235,298,0.0259277350196,0.0701553803173642,"0.584,0.57","0.523,0.466",0.082]
[16257,"ENSG00000187118.13","CMC1","chr3","+",28263290,28263380,28316332,28316423,28253730,28253765,28319508,28319773,16257,"22,25",270303,"13,10",225242,239,240,0.0513237480702,0.122928610530788,"0.076,0.077","0.055,0.04",0.029]
[16320,"ENSG00000169919.16","GUSB","chr7","-",65979398,65979541,65979726,65979911,65967730,65967907,65980223,65980409,16320,856891,"11,17",463446,"5,6",298,292,0.322564131264,0.509611409462158,"0.987,0.981","0.989,0.986",-0.004]
[16350,"ENSG00000223745.7","CCDC18-AS1","chr1","-",93339648,93339679,93340457,93340510,93338937,93339536,93345723,93345846,16350,"6,9","59,54","5,0","20,14",202,180,0.744362759477,0.890682769250949,"0.083,0.129","0.182,0.0",0.015]
[16408,"ENSG00000114648.11","KLHL18","chr3","+",47340571,47340676,47342718,47342830,47336534,47336757,47343554,47344577,16408,100108,120124,177184,228253,254,261,0.413834125145,0.605485378516833,"0.461,0.472","0.444,0.428",0.031]
[16429,"ENSG00000177463.15","NR2C2","chr3","+",15003875,15003986,15013588,15013789,14947583,14947906,15016151,15016254,16429,"25,14",124116,"63,61",162134,260,298,{"v":1.04820369189e-05,"d":"1.05E-05"},{"v":6.9006998983523e-05,"d":"6.90E-05"},"0.188,0.122","0.308,0.343",-0.171]
[16493,"ENSG00000123600.19","METTL8","chr2","-",171330558,171330698,171339183,171339554,171326041,171326148,171360421,171360513,16493,198187,176158,80114,"33,57",298,289,3.26283812971E-4,1.56217153071497E-3,"0.522,0.534","0.702,0.66",-0.153]
[16519,"ENSG00000127616.18","SMARCA4","chr19","+",11007901,11008023,11010380,11010531,11003339,11003397,11012948,11013112,16519,470508,11071093,436415,662616,271,298,4.80699572082E-4,0.00221374025109867,"0.318,0.338","0.42,0.426",-0.095]
[16582,"ENSG00000214960.9","ISPD","chr7","-",16301420,16301466,16308522,16308627,16278128,16278226,16376091,16376241,16582,114110,"69,91","40,50","13,24",254,195,0.024735878036,0.0675650916108538,"0.559,0.481","0.703,0.615",-0.139]
[16644,"ENSG00000075711.20","DLG1","chr3","-",197149742,197149796,197194424,197194589,197142717,197142768,197282678,197282845,16644,226205,"76,49",299195,"68,62",298,203,0.656573535915,0.824542691279116,"0.669,0.74","0.75,0.682",-0.011]
[16703,"ENSG00000127329.15","PTPRB","chr12","-",70571823,70572087,70576381,70576645,70571025,70571289,70581035,70581302,16703,"2,5","3,4","2,2","10,7",298,298,0.0445168719152,0.10933829646333,"0.4,0.556","0.167,0.222",0.284]
[16734,"ENSG00000141524.15","TMC6","chr17","-",78121012,78121164,78121555,78121711,78119296,78119392,78122604,78122748,16734,337308,"45,62",243247,239289,298,298,0,0,"0.882,0.832","0.504,0.461",0.374]
[16800,"ENSG00000106636.7","YKT6","chr7","+",44206384,44206485,44207387,44207492,44204567,44204650,44208132,44208198,16800,318310,532447,424436,516556,250,254,0.0675943133392,0.153681590370852,"0.378,0.413","0.455,0.443",-0.054]
[16809,"ENSG00000122515.14","ZMIZ2","chr7","+",44761694,44761905,44762880,44762986,44761448,44761593,44763255,44763413,16809,136170,114115,117145,"78,75",298,255,0.134612061813,0.265515033767263,"0.505,0.558","0.562,0.623",-0.061]
[16889,"ENSG00000134882.15","UBAC2","chr13","+",99243831,99243951,99318021,99318069,99238426,99238554,99340319,99340565,16889,266276,420335,127145,306311,269,197,2.62689960505E-4,0.00128676274745734,"0.317,0.376","0.233,0.255",0.103]
[16907,"ENSG00000111596.12","CNOT2","chr12","+",70278131,70278274,70310894,70311017,70242993,70243480,70319297,70319364,16907,"66,66",451370,"131,77",268219,292,272,{"v":1.94485083593E-9,"d":"1.94E-09"},{"v":2.19702631636556e-08,"d":"2.20E-08"},"0.12,0.142","0.313,0.247",-0.149]
[16944,"ENSG00000109445.10","ZNF330","chr4","+",141226766,141226846,141230165,141230270,141224606,141224677,141231438,141231485,16944,276244,507458,223227,363436,229,254,0.715860732997,0.869770984140463,"0.376,0.371","0.405,0.366",-0.012]
[16989,"ENSG00000277149.4","TYW1B","chr7","-",72807065,72807356,72815379,72815481,72802399,72802522,72826854,72826985,16989,"7,6","9,9","22,11","28,10",251,298,0.651410669341,0.820536997819392,"0.48,0.442","0.483,0.566",-0.064]
[17060,"ENSG00000100591.7","AHSA1","chr14","+",77462641,77462759,77468082,77468184,77462159,77462242,77469076,77469470,17060,17331330,"1,4",840871,"2,2",267,251,1,1,"0.999,0.997","0.997,0.998",0]
[17127,"ENSG00000001631.15","KRIT1","chr7","-",92235402,92235646,92236412,92236542,92234807,92234923,92237666,92237759,17127,333317,348278,128132,167137,279,298,0.169110853707,0.316303319066226,"0.505,0.549","0.45,0.507",0.048]
[17171,"ENSG00000137807.15","KIF23","chr15","+",69446285,69446364,69446430,69446587,69446008,69446091,69446870,69446941,17171,300286,"14,7",419392,"35,45",228,298,{"v":3.38122621835e-05,"d":"3.38E-05"},0.000202486065831839,"0.966,0.982","0.94,0.919",0.044]
[17225,"ENSG00000215126.10","CBWD6","chr9","-",41133673,41133742,41145280,41145332,41133504,41133570,41162332,41162377,17225,"1,1","32,15","4,11","24,23",201,218,0.000350638830585,0.00166740822950568,"0.033,0.067","0.153,0.342",-0.198]
[17243,"ENSG00000121716.20","PILRB","chr7","+",100355142,100355240,100356749,100356883,100353209,100353270,100358219,100358366,17243,"20,27",169157,"24,22",157174,247,283,0.88484263573,0.988098463407254,"0.119,0.165","0.149,0.127",0.004]
[17309,"ENSG00000105821.14","DNAJC2","chr7","-",103323597,103323663,103324481,103324562,103322702,103322794,103326542,103326684,17309,246209,425297,254253,276241,230,215,0.00096762634442,0.00415947892343083,"0.351,0.397","0.462,0.495",-0.105]
[17326,"ENSG00000091127.13","PUS7","chr7","-",105470760,105470848,105472131,105472193,105468336,105468463,105481051,105481177,17326,118118,"26,20","33,44","9,13",211,237,0.283266150222,0.464475452772248,"0.836,0.869","0.805,0.792",0.054]
[17391,"ENSG00000006715.15","VPS41","chr7","-",38776678,38776776,38789800,38789867,38774114,38774244,38795464,38795611,17391,"102,72",139157,131115,157156,216,247,0.121880919955,0.24563121270687,"0.456,0.344","0.488,0.457",-0.073]
[17476,"ENSG00000106554.12","CHCHD3","chr7","-",132885661,132885745,132975168,132975286,132838398,132838469,133024545,133024627,17476,9811017,670576,789819,485553,267,233,0.760818691812,0.903246073461049,"0.561,0.606","0.587,0.564",0.008]
[17493,"ENSG00000116001.15","TIA1","chr2","-",70215370,70215494,70216207,70216292,70214348,70214494,70216403,70216499,17493,373291,549474,141173,167190,234,273,0.0246084646852,0.0672497680627291,"0.442,0.417","0.496,0.515",-0.076]
[17556,"ENSG00000278535.4","DHRS11","chr17","+",36594970,36595180,36598162,36598257,36591797,36592156,36598920,36599050,17556,79110,159175,"35,10","66,63",298,244,0.0489283739411,0.118237431069324,"0.289,0.34","0.303,0.115",0.106]
[17607,"ENSG00000123607.14","TTC21B","chr2","-",165945523,165945690,165949393,165949504,165943218,165943341,165949594,165949724,17607,"79,70","68,48","28,49","38,24",260,298,0.899865699448,0.998559284231249,"0.571,0.626","0.458,0.701",0.019]
[17641,"ENSG00000106615.9","RHEB","chr7","-",151477332,151477415,151484736,151484804,151471548,151471605,151490942,151491014,17641,608667,930839,813858,722745,217,232,{"v":4.71342165196e-05,"d":"4.71E-05"},0.000272041795781888,"0.411,0.459","0.546,0.552",-0.114]
[17702,"ENSG00000114126.17","TFDP2","chr3","-",141995019,141995141,142093060,142093127,141993537,141993585,142101734,142101757,17702,"14,12",540490,"26,17",659724,216,271,0.39719425789,0.588807665140226,"0.032,0.03","0.047,0.029",-0.007]
[17737,"ENSG00000181804.14","SLC9A9","chr3","-",143652254,143652360,143693191,143693307,143578584,143578723,143795000,143795077,17737,"8,4","8,9","5,1","3,4",265,255,0.972782036625,1,"0.49,0.3","0.616,0.194",-0.01]
[17788,"ENSG00000136536.14","2024-03-07","chr2","+",159743060,159743253,159745769,159745937,159729008,159729175,159747804,159748903,17788,604577,693556,771776,735847,298,298,0.785913674311,0.921403305405367,"0.466,0.509","0.512,0.478",-0.007]
[17813,"ENSG00000078674.17","PCM1","chr8","+",17939690,17939861,17947185,17947363,17938739,17939009,17950614,17950724,17813,442442,555495,398414,430388,298,298,0.173338435378,0.322385672089088,"0.443,0.472","0.481,0.516",-0.041]
[17886,"ENSG00000149577.15","SIDT2","chr11","+",117193152,117193258,117193852,117193963,117192819,117192866,117195801,117195915,17886,"48,65","9,12",103129,"30,28",255,260,0.247041232353,0.420003741657048,"0.845,0.847","0.778,0.824",0.045]
[17920,"ENSG00000104691.14","UBXN8","chr8","+",30756764,30756887,30760887,30760929,30753034,30753105,30763272,30763347,17920,"14,18",161119,"87,49",218221,272,191,{"v":1.35679072559E-5,"d":"1.36E-05"},{"v":8.7725760490633e-05,"d":"8.77E-05"},"0.058,0.096","0.219,0.135",-0.1]
[17972,"ENSG00000254673.1","AC110275.1","chr8","+",43064100,43064215,43069554,43069659,43059091,43059177,43072180,43072307,17972,527573,776713,227301,293384,264,254,0.6666008707,0.831745936472132,"0.395,0.436","0.427,0.43",-0.013]
[18034,"ENSG00000265257.5","AP005263.1","chr18","+",9124873,9124983,9126830,9126907,9122512,9122681,9134185,9134292,18034,12261164,663545,8501013,365571,259,226,0.877043681399,0.983686961112358,"0.617,0.651","0.67,0.608",-0.005]
[18067,"ENSG00000149929.15","HIRIP3","chr16","-",29995102,29995217,29995342,29995463,29993905,29994843,29995540,29996436,18067,274289,440427,226233,222217,270,264,0.000295423860488,0.00142934511656004,"0.378,0.398","0.499,0.512",-0.118]
[18120,"ENSG00000174799.10","CEP135","chr4","+",55991933,55992085,55999301,55999417,55985280,55985358,55999490,55999645,18120,"59,64","53,39",123126,91143,298,265,0.342766996383,0.531999728683398,"0.497,0.593","0.546,0.439",0.052]
[18138,"ENSG00000066777.8","ARFGEF1","chr8","-",67277281,67277457,67287954,67288065,67275975,67276109,67291846,67292123,18138,162139,226204,137125,141150,260,298,0.0947666752375,0.201830561697761,"0.451,0.439","0.527,0.489",-0.063]
[18210,"ENSG00000133731.9","IMPA1","chr8","-",81679125,81679230,81680649,81680783,81676233,81676279,81681497,81681584,18210,365407,177153,341385,156150,283,254,0.925509099978,1,"0.649,0.705","0.662,0.697",-2E-3]
[18234,"ENSG00000176623.11","RMDN1","chr8","-",86474819,86474914,86477293,86477324,86474020,86474358,86478922,86479010,18234,"98,78","96,97","42,28","27,30",180,244,0.236929325986,0.406844862482188,"0.581,0.522","0.678,0.559",-0.067]
[18299,"ENSG00000138346.14","DNA2","chr10","-",68422224,68422429,68430435,68430540,68419802,68419892,68431856,68431971,18299,"8,1",289258,"0,0","81,80",254,298,0.387960175041,0.579092351889738,"0.031,0.005","0.0,0.0",0.018]
[18343,"ENSG00000153107.12","ANAPC1","chr2","-",111802427,111802506,111803447,111803530,111800796,111800871,111803704,111803839,18343,"115,94","39,27","61,61","32,34",232,228,0.0190096785458,0.0542537059652358,"0.743,0.774","0.652,0.638",0.113]
[18380,"ENSG00000164010.14","ERMAP","chr1","+",42835731,42835764,42840032,42840053,42835037,42835154,42840151,42840178,18380,"55,50","88,37","65,58","51,55",182,170,0.370484157513,0.5612465301483,"0.369,0.558","0.543,0.496",-0.056]
[18450,"ENSG00000166579.15","NDEL1","chr17","+",8454795,8454887,8460008,8460160,8450779,8450953,8463319,8463354,18450,344337,"23,6",257279,"12,19",241,298,0.282183749835,0.463252926977381,"0.949,0.986","0.964,0.948",0.012]
[18467,"ENSG00000146463.11","ZMYM4","chr1","+",35370371,35370627,35381258,35381433,35370028,35370113,35381545,35381758,18467,451457,494454,276264,170214,298,298,3.0743170113E-3,0.0114214333543154,"0.477,0.502","0.619,0.552",-0.096]
[18514,"ENSG00000153310.19","FAM49B","chr8","-",129880375,129880458,129894486,129894564,129879388,129879471,129903311,129903350,18514,"1,0","13,19","0,0","2,0",227,232,1,1,"0.073,0.0","0.0,NA",0.036]
[18553,"ENSG00000129292.20","PHF20L1","chr8","+",132777795,132777911,132794409,132794581,132775357,132775645,132794732,132794817,18553,"47,53",209193,107101,286272,265,298,0.0154805470487,0.0455039784978074,"0.202,0.236","0.296,0.295",-0.076]
[18617,"ENSG00000114770.16","ABCC5","chr3","-",183963384,183963588,183965184,183965257,183961510,183961654,183965376,183965501,18617,"54,63",137156,"18,18","60,71",222,298,0.0968812095713,0.205399499703485,"0.346,0.352","0.287,0.254",0.079]
[18646,"ENSG00000107669.17","ATE1","chr10","-",121836717,121836817,121841081,121841263,121790168,121790289,121870005,121870038,18646,92113,"59,95",102132,"70,68",298,249,0.211678334698,0.374474490381022,"0.566,0.498","0.549,0.619",-0.052]
[18700,"ENSG00000234906.9","APOC2","chr19","+",44948465,44948533,44948700,44948818,44946055,44946075,44949158,44949399,18700,"29,19","8,6","11,16","4,14",217,267,0.100804561255,0.211997162751646,"0.817,0.796","0.772,0.584",0.129]
[18764,"ENSG00000147854.16","UHRF2","chr9","+",6486820,6486925,6492302,6492401,6481991,6482099,6493825,6493932,18764,416351,"32,36",522506,"96,95",254,248,{"v":2.00432183391e-05,"d":"2.00E-05"},1.25480934204858E-4,"0.927,0.905","0.841,0.839",0.076]
[18793,"ENSG00000164946.19","FREM1","chr9","-",14819233,14819442,14841446,14841589,14816777,14816871,14842315,14842660,18793,483381,369425,491475,419429,292,298,0.732308146925,0.881495058497016,"0.572,0.478","0.545,0.531",-0.013]
[18848,"ENSG00000136100.13","VPS36","chr13","-",52426988,52427066,52427186,52427219,52425931,52426066,52433661,52433748,18848,187151,563557,"100,77",431421,182,227,0.00864763393561,0.0277378568021728,"0.293,0.253","0.224,0.186",0.068]
[18911,"ENSG00000198876.12","DCAF12","chr9","-",34093285,34093448,34096715,34096781,34089411,34089590,34098323,34098517,18911,231289,948902,270250,795828,215,298,0.276853317972,0.457028668100276,"0.252,0.308","0.32,0.295",-0.027]
[18923,"ENSG00000139697.13","SBNO1","chr12","-",123313619,123313719,123315372,123315444,123311054,123311129,123315547,123315660,18923,335238,208247,308321,243246,221,249,0.865924801631,0.977024423413023,"0.645,0.521","0.588,0.595",-0.008]
[18993,"ENSG00000121897.14","LIAS","chr4","+",39465284,39465342,39466016,39466117,39463524,39463605,39467517,39467646,18993,158135,"1,0","18,25","0,0",207,250,1,1,"0.995,1.0","1.0,1.0",-2E-3]
[19015,"ENSG00000084234.17","APLP2","chr11","+",130135562,130135715,130140397,130140483,130133628,130133728,130141497,130141572,19015,26392454,12781165,16521582,16641934,298,235,{"v":2.10942374679e-15,"d":"2.11E-15"},{"v":4.47983385317812e-14,"d":"4.48E-14"},"0.62,0.624","0.439,0.392",0.207]
[19078,"ENSG00000165060.12","FXN","chr9","+",69046384,69046482,69064937,69065035,69035562,69035947,69099900,69100178,19078,146146,"5,14","123,99","20,22",247,247,2.16623225341E-4,1.08114332523032E-3,"0.967,0.912","0.86,0.818",0.101]
[19134,"ENSG00000111321.10","LTBR","chr12","+",6385226,6385379,6386346,6386444,6385118,6385147,6388799,6388825,19134,657690,"20,34",875880,211269,298,247,0,0,"0.965,0.944","0.775,0.731",0.201]
[19161,"ENSG00000188312.13","CENPP","chr9","+",92337540,92337629,92345698,92345787,92332169,92332351,92379762,92379859,19161,84100,"81,73","45,41","45,55",238,238,0.124361635246,0.249289105392307,"0.509,0.578","0.5,0.427",0.08]
[19227,"ENSG00000136925.14","TSTD2","chr9","-",97610345,97610451,97617756,97617877,97606142,97606261,97625680,97625997,19227,"97,83","78,67",163107,187168,270,255,0.00443452003662,0.0156566987276578,"0.54,0.539","0.452,0.376",0.126]
[19268,"ENSG00000136813.14","ECPAS","chr9","-",111373971,111374038,111375112,111375202,111373314,111373406,111376475,111376541,19268,263237,211223,285293,193197,239,216,0.063695892303,0.146457532148598,"0.53,0.49","0.572,0.573",-0.062]
[19312,"ENSG00000095261.13","PSMD5","chr9","-",120831330,120831459,120831831,120831945,120829098,120829208,120833311,120833456,19312,231164,374304,"94,82","121,98",263,278,0.0363527462698,0.0929883715774289,"0.395,0.363","0.451,0.469",-0.081]
[19329,"ENSG00000119397.16","CNTRL","chr9","+",121150169,121150483,121152484,121152693,121148671,121148861,121154720,121154913,19329,331304,313280,187160,243206,298,298,0.0157929613083,0.0462729016159027,"0.514,0.521","0.435,0.437",0.082]
[19371,"ENSG00000119414.11","PPP6C","chr9","-",125158240,125158382,125171084,125171180,125153905,125153985,125189643,125189818,19371,348283,858897,357349,607615,245,291,{"v":6.91189125887E-5,"d":"6.91E-05"},0.000386038490418966,"0.325,0.273","0.411,0.403",-0.108]
[19412,"ENSG00000148343.18","MIGA2","chr9","+",129068018,129068332,129069075,129069129,129067772,129067871,129069848,129069965,19412,"1,3","40,43","3,5","40,32",298,203,0.119673522752,0.242116367973589,"0.017,0.045","0.049,0.096",-0.042]
[19473,"ENSG00000109118.13","PHF12","chr17","-",28906855,28906994,28907589,28907672,28905249,28906517,28908782,28908881,19473,158106,399378,"125,79",384356,232,288,0.174271823465,0.323692948783589,"0.33,0.258","0.288,0.216",0.042]
[19546,"ENSG00000213593.9","TMX2","chr11","+",57737607,57737668,57739130,57739260,57712602,57712807,57740098,57740973,19546,534516,967902,253238,412388,210,279,0.472263260825,0.661990976960347,"0.423,0.432","0.449,0.449",-0.022]
[19560,"ENSG00000127947.15","PTPN12","chr7","+",77571077,77571186,77592184,77592256,77537274,77537645,77597841,77597901,19560,133117,156153,138111,149164,258,221,0.913290164319,1,"0.422,0.396","0.442,0.367",0.005]
[19633,"ENSG00000167522.15","ANKRD11","chr16","-",89291012,89291183,89316932,89317078,89290624,89290828,89418283,89418368,19633,256361,411387,455494,781875,295,298,0.0515739839088,0.123383288378069,"0.386,0.485","0.37,0.363",0.069]
[19685,"ENSG00000077420.15","APBB1IP","chr10","+",26560104,26560203,26560729,26560844,26541581,26541692,26562325,26562429,19685,460381,398411,344349,365323,248,264,0.826838571417,0.949467770285101,"0.552,0.497","0.501,0.535",0.006]
[19716,"ENSG00000160193.11","WDR4","chr21","-",42873550,42873691,42876701,42876767,42863439,42863596,42879406,42879531,19716,261295,481495,171175,153163,215,290,{"v":1.73448384833e-06,"d":"1.73E-06"},{"v":1.2969090711523E-5,"d":"1.30E-05"},"0.423,0.446","0.601,0.592",-0.162]
[19784,"ENSG00000198298.12","ZNF485","chr10","+",43608613,43608740,43609254,43609350,43606996,43607074,43616290,43616395,19784,"7,5","20,21","9,7","16,6",276,245,0.0541662099408,0.128598961449686,"0.237,0.174","0.333,0.509",-0.216]
[19801,"ENSG00000249967.1","AL355315.1","chr10","+",97656820,97656974,97662906,97662968,97656284,97656416,97664884,97664984,19801,"83,93","56,23",132146,"49,40",298,211,0.397940764255,0.589447625555118,"0.512,0.741","0.656,0.721",-0.062]
[19858,"ENSG00000204130.13","RUFY2","chr10","-",68393137,68393203,68394074,68394136,68386058,68386128,68394327,68394451,19858,"5,5","23,27","11,10","20,25",211,215,0.0404001777329,0.1013454944156,"0.181,0.159","0.359,0.29",-0.155]
[19890,"ENSG00000166295.8","ANAPC16","chr10","+",72220053,72220379,72230365,72230440,72215999,72216138,72233000,72235858,19890,174149,422391,193203,294348,298,224,1.07190919167E-3,4.54514580630934E-3,"0.237,0.223","0.33,0.305",-0.088]
[19956,"ENSG00000174953.13","DHX36","chr3","-",154295283,154295297,154299837,154299925,154293747,154293812,154300593,154300696,19956,248209,"25,1","100,90","15,17",237,163,0.000316465446922,0.00152099724639367,"0.872,0.993","0.821,0.785",0.13]
[20007,"ENSG00000105397.13","TYK2","chr19","-",10352925,10353098,10353527,10353646,10351051,10351162,10354041,10354234,20007,160166,"7,6","70,95","30,6",268,298,{"v":8.24261844454e-05,"d":"8.24E-05"},0.000451936051318616,"0.962,0.969","0.722,0.946",0.132]
[20037,"ENSG00000198836.9","OPA1","chr3","+",193615673,193615770,193617177,193617285,193593143,193593409,193618868,193618936,20037,"16,19",326273,"16,15",223215,246,257,0.51837320191,0.705855855627888,"0.049,0.068","0.07,0.068",-0.011]
[20098,"ENSG00000112312.9","GMNN","chr6","+",24777221,24777297,24780662,24780740,24774930,24775112,24781476,24781621,20098,235189,845879,194186,651710,225,227,0.312297806395,0.498686618711481,"0.219,0.178","0.231,0.209",-0.021]
[20135,"ENSG00000120008.15","WDR11","chr10","+",120890715,120890887,120900028,120900137,120889894,120890009,120901035,120901098,20135,200226,113123,"59,82",118109,298,258,{"v":3.67770536247e-09,"d":"3.68E-09"},{"v":4.00554347015697e-08,"d":"4.01E-08"},"0.605,0.614","0.302,0.394",0.261]
[20183,"ENSG00000107566.13","ERLIN1","chr10","-",100167347,100167406,100174207,100174281,100164003,100164095,100175944,100176070,20183,221181,"86,77","87,87","35,40",223,208,0.789649524664,0.923895293454068,"0.706,0.687","0.699,0.67",0.012]
[20200,"ENSG00000075826.16","SEC31B","chr10","-",100489702,100489761,100490705,100490883,100488857,100488974,100495384,100495546,20200,136153,"0,0",409379,"16,24",298,208,{"v":8.59686581922e-07,"d":"8.60E-07"},{"v":6.78240793862549e-06,"d":"6.78E-06"},"1.0,1.0","0.947,0.917",0.068]
[20264,"ENSG00000092020.10","PPP2R3C","chr14","-",35107303,35107374,35109847,35109931,35099251,35099384,35110524,35110629,20264,220208,105109,165165,"77,91",233,220,0.924590750225,1,"0.664,0.643","0.669,0.631",0.003]
[20332,"ENSG00000167792.12","NDUFV1","chr11","+",67610994,67611207,67611896,67611978,67610380,67610570,67612119,67612265,20332,1046974,776706,762841,609611,298,231,0.737329103128,0.885512192965045,"0.511,0.517","0.492,0.516",0.01]
[20356,"ENSG00000249115.8","HAUS5","chr19","+",35617854,35617912,35618070,35618195,35617286,35617369,35618401,35618465,20356,"66,74",141172,"60,43","115,97",207,274,0.678849945256,0.840813960726111,"0.383,0.363","0.408,0.37",-0.016]
[20420,"ENSG00000125257.14","ABCC4","chr13","-",95210691,95210781,95246974,95247095,95209433,95209597,95247642,95247753,20420,12121096,758730,831881,632606,270,239,0.309079450359,0.495044240754923,"0.586,0.571","0.538,0.563",0.028]
[20439,"ENSG00000148803.11","FUOM","chr10","-",133356639,133356738,133356942,133357013,133355737,133355811,133357186,133357255,20439,"97,94","55,63","31,25","30,25",220,248,0.0591511129209,0.137841356172962,"0.665,0.627","0.538,0.53",0.112]
[20505,"ENSG00000148985.19","PGAP2","chr11","+",3811249,3811424,3824269,3824376,3808293,3808315,3825019,3825128,20505,"18,22","69,86","12,20","30,23",298,256,0.0175531096128,0.0506876776622546,"0.183,0.18","0.256,0.428",-0.16]
[20522,"ENSG00000142327.12","RNPEPL1","chr2","+",240573774,240573891,240574112,240574348,240573109,240573261,240574514,240574628,20522,"111,88",175205,"81,90",120119,266,298,0.084971292872,0.184769184122807,"0.415,0.325","0.431,0.459",-0.075]
[20585,"ENSG00000120686.11","UFM1","chr13","+",38354238,38354296,38359300,38359333,38349998,38350055,38360710,38363619,20585,"36,29",110112,"53,61",107135,207,182,0.0180699784397,0.0519266332730041,"0.223,0.185","0.303,0.284",-0.089]
[20649,"ENSG00000074319.12","TSG101","chr11","-",18506856,18506923,18509541,18509665,18502485,18502577,18514677,18514841,20649,370360,218172,413443,275285,273,216,0.111682899726,0.229399677661897,"0.573,0.623","0.543,0.552",0.05]
[20668,"ENSG00000109881.16","CCDC34","chr11","-",27350331,27350439,27357402,27357541,27341391,27341550,27362835,27363868,20668,255242,193252,288290,154145,288,257,0.000255152576291,0.00125366788468893,"0.541,0.461","0.625,0.641",-0.132]
[20716,"ENSG00000174839.12","DENND6A","chr3","-",57666122,57666235,57672399,57672438,57663635,57663716,57692781,57693089,20716,"30,26","76,63","19,20","45,54",188,262,0.922570136952,1,"0.355,0.365","0.37,0.34",0.005]
[20751,"ENSG00000166199.12","ALKBH3","chr11","+",43892040,43892129,43897194,43897354,43889724,43889828,43901515,43901725,20751,466509,"1,0","12,5","0,5",238,298,0.00587581084143,0.0199040545448651,"0.998,1.0","1.0,0.556",0.221]
[20812,"ENSG00000182670.13","TTC3","chr21","+",37094004,37094090,37095349,37095444,37091292,37091413,37096580,37096643,20812,250262,267265,169173,168216,235,244,0.597520728659,0.774574121746903,"0.493,0.507","0.511,0.454",0.017]
[20844,"ENSG00000110031.12","LPXN","chr11","-",58554840,58554940,58564154,58564201,58551064,58551232,58570555,58570713,20844,156127,154174,138155,279258,196,249,0.00388353606132,0.0139793610640498,"0.563,0.481","0.386,0.433",0.113]
[20902,"ENSG00000149483.11","TMEM138","chr11","+",61364251,61364518,61366044,61366216,61362000,61362420,61367922,61367998,20902,"56,59",146129,"45,67","85,72",298,298,0.0254791847592,0.0691632779013269,"0.277,0.314","0.346,0.482",-0.118]
[20969,"ENSG00000168000.14","BSCL2","chr11","-",62702467,62702549,62705300,62705617,62694567,62694711,62705915,62706234,20969,"12,2","60,44","1,12","40,34",298,231,0.685230156731,0.846246080134992,"0.134,0.034","0.019,0.215",-0.033]
[20980,"ENSG00000136448.11","NMT1","chr17","+",45086507,45086652,45093684,45093803,45081643,45081752,45096193,45096285,20980,13641374,628690,10721118,616625,294,268,0.141123510648,0.2753089636274,"0.664,0.645","0.613,0.62",0.038]
[21047,"ENSG00000136738.14","STAM","chr10","+",17660463,17660548,17684674,17684750,17644124,17644379,17684831,17684927,21047,175142,401383,197244,419422,234,225,0.0516251509319,0.123451443995415,"0.296,0.263","0.311,0.357",-0.054]
[21068,"ENSG00000111300.9","NAA25","chr12","-",112054387,112054568,112060269,112060359,112053557,112053657,112061180,112061388,21068,"57,80",230259,"35,31",115121,239,298,1,1,"0.236,0.278","0.275,0.242",-2E-3]
[21129,"ENSG00000132740.8","IGHMBP2","chr11","+",68929182,68929357,68933298,68933481,68917735,68917883,68933794,68933913,21129,136146,133132,290280,178186,298,298,0.00877907124486,0.028071289568914,"0.506,0.525","0.62,0.601",-0.095]
[21190,"ENSG00000137478.14","FCHSD2","chr11","-",72843448,72843532,72849754,72849879,72843227,72843328,72867864,72868026,21190,"10,7",217193,"3,8",284303,274,233,0.0440063587062,0.108383083828741,"0.038,0.03","0.009,0.022",0.019]
[21213,"ENSG00000148110.15","MFSD14B","chr9","+",94440984,94441099,94444963,94445182,94438400,94438528,94446822,94446936,21213,115140,171179,"52,40",148141,264,298,{"v":1.6198753352e-06,"d":"1.62E-06"},{"v":1.21851285258147E-5,"d":"1.22E-05"},"0.432,0.469","0.284,0.243",0.187]
[21277,"ENSG00000073578.16","SDHA","chr5","+",233476,233645,240357,240476,230875,231000,254392,254506,21277,743635,"68,55",208204,"15,16",298,268,0.360420026405,0.551278255499928,"0.908,0.912","0.926,0.92",-0.013]
[21293,"ENSG00000078124.11","ACER3","chr11","+",76958978,76959031,76959076,76959200,76926556,76926667,76976288,76976341,21293,179142,"2,5",184155,"4,2",202,273,0.698855697474,0.857736679463385,"0.992,0.975","0.984,0.991",-0.004]
[21363,"ENSG00000073417.14","PDE8A","chr15","+",85115983,85116119,85123060,85123193,85115438,85115487,85126206,85126374,21363,"123,94","117,88","73,39","66,64",285,282,0.325637264836,0.512951745905782,"0.51,0.514","0.523,0.376",0.062]
[21380,"ENSG00000073921.17","PICALM","chr11","-",86022366,86022469,86026291,86026367,86014869,86014963,86031468,86031611,21380,659499,1011892,402402,825822,225,252,0.0623093554714,0.143843512594974,"0.422,0.385","0.353,0.354",0.05]
[21424,"ENSG00000182919.14","C11orf54","chr11","+",93755209,93755386,93757315,93757465,93753935,93754037,93759741,93759858,21424,194153,176190,363250,378349,298,298,0.410763153124,0.602286432233304,"0.524,0.446","0.49,0.417",0.031]
[21513,"ENSG00000086827.8","ZW10","chr11","-",113748256,113748420,113757661,113757853,113747530,113747713,113758553,113758706,21513,280298,398373,122123,290319,298,298,{"v":4.70354557092e-06,"d":"4.70E-06"},{"v":3.27702218396903e-05,"d":"3.28E-05"},"0.413,0.444","0.296,0.278",0.141]
[21534,"ENSG00000109917.10","ZPR1","chr11","-",116782157,116782244,116782918,116783029,116779771,116779837,116783529,116783619,21534,713618,492491,507478,406400,260,236,0.395951501737,0.587546842724121,"0.568,0.533","0.531,0.52",0.025]
[21605,"ENSG00000106868.16","SUSD1","chr9","-",112052398,112052438,112078537,112078724,112041866,112041960,112080073,112080165,21605,369308,"46,24",317349,"38,57",298,189,0.0893253267667,0.192356791941823,"0.836,0.891","0.841,0.795",0.045]
[21616,"ENSG00000106868.16","SUSD1","chr9","-",112112770,112112868,112124256,112124436,112111649,112111840,112142319,112142466,21616,266287,226235,270310,294336,298,247,0.0441085805372,0.108587235246011,"0.494,0.503","0.432,0.433",0.066]
[21683,"ENSG00000002016.17","RAD52","chr12","-",926795,926946,927144,927263,925449,925525,930050,930144,21683,192180,"17,16",133130,"2,4",268,298,2.33582625778E-4,1.15565185317714E-3,"0.926,0.926","0.987,0.973",-0.054]
[21701,"ENSG00000111206.12","FOXM1","chr12","-",2865354,2865399,2866392,2866521,2864682,2864752,2872095,2872247,21701,241282,"38,41","99,74","41,65",278,194,{"v":4.6286478117e-07,"d":"4.63E-07"},{"v":3.78323345511412e-06,"d":"3.78E-06"},"0.816,0.828","0.628,0.443",0.286]
[21774,"ENSG00000093010.13","COMT","chr22","+",19962526,19962815,19963565,19963759,19961198,19961289,19964167,19964299,21774,654689,11191235,327269,604698,298,298,0.0724244267642,0.162484216674064,"0.369,0.358","0.351,0.278",0.049]
[21833,"ENSG00000092199.17","HNRNPC","chr14","-",21262600,21262768,21263310,21263336,21233952,21234229,21263666,21263829,21833,16911759,"78,50",12101378,"56,55",175,298,0.394971743474,0.586615650696741,"0.974,0.984","0.974,0.977",0.003]
[21851,"ENSG00000111731.12","C2CD5","chr12","-",22471966,22472065,22472285,22472347,22471398,22471488,22472743,22472807,21851,"106,77","102,92","52,35","88,78",211,248,0.00234236354511,0.00901208330395147,"0.55,0.496","0.41,0.345",0.146]
[21924,"ENSG00000214548.16","MEG3","chr14","+",100831420,100831534,100835735,100835879,100831015,100831094,100836166,100836300,21924,"30,25",473445,76120,357353,263,293,{"v":9.99200722163e-16,"d":"9.99E-16"},{"v":2.2010824535569e-14,"d":"2.20E-14"},"0.066,0.059","0.192,0.275",-0.171]
[21936,"ENSG00000214548.16","MEG3","chr14","+",100834631,100834751,100835735,100835879,100832511,100832641,100836166,100836300,21936,"17,17",472446,"12,3",355352,269,293,0.0571678279672,0.134137836946012,"0.038,0.04","0.036,0.009",0.017]
[22002,"ENSG00000156650.13","KAT6B","chr10","+",74972506,74972639,74975398,74976330,74970019,74970101,74977315,74977437,22002,"42,37","44,52","21,9","41,22",282,298,0.0467832979488,0.113985461029233,"0.502,0.429","0.351,0.302",0.139]
[22058,"ENSG00000066117.14","SMARCD1","chr12","+",50087362,50087485,50088520,50088637,50086755,50086878,50089883,50089985,22058,644567,10371049,362407,537520,272,266,0.0526108926848,0.125423251749047,"0.378,0.346","0.397,0.434",-0.053]
[22085,"ENSG00000110911.15","SLC11A2","chr12","-",51008475,51008544,51008585,51008624,51005310,51005436,51010694,51010766,22085,"39,57","55,55","68,46","71,94",188,218,0.407093614755,0.598350652837711,"0.451,0.546","0.526,0.362",0.055]
[22154,"ENSG00000135387.20","CAPRIN1","chr11","+",34097195,34097296,34097697,34097761,34096478,34096673,34099302,34099388,22154,1017918,10581019,767767,583546,250,213,0.000717792810362,0.00318359389183256,"0.45,0.434","0.529,0.545",-0.095]
[22197,"ENSG00000139641.12","ESYT1","chr12","+",56138182,56138272,56138403,56138499,56138025,56138074,56138767,56138839,22197,10541008,842774,520558,297346,239,245,0.0185172468593,0.0530507158289821,"0.562,0.572","0.642,0.623",-0.066]
[22243,"ENSG00000183735.9","TBK1","chr12","+",64488486,64488588,64490040,64490119,64485925,64486017,64495482,64495604,22243,"112,97",226183,225163,384400,251,228,0.807288613611,0.935504033560819,"0.31,0.325","0.347,0.27",0.009]
[22264,"ENSG00000163785.12","RYK","chr3","-",134175608,134175768,134175929,134176039,134159282,134159373,134183001,134183071,22264,"7,3",228198,"2,2",103134,259,298,0.351625474091,0.541494876648651,"0.034,0.017","0.022,0.017",0.006]
[22333,"ENSG00000177192.13","PUS1","chr12","+",131939172,131939275,131941291,131941983,131931514,131932312,131943538,131943859,22333,283283,488496,134177,461476,252,298,{"v":2.03063720844e-05,"d":"2.03E-05"},1.26916237653514E-4,"0.407,0.403","0.256,0.305",0.125]
[22396,"ENSG00000185480.11","PARPBP","chr12","+",102182548,102182627,102195311,102195447,102165728,102165883,102195950,102197361,22396,"94,90","78,66","37,42","13,23",228,285,0.0258427785795,0.0699676336790921,"0.601,0.63","0.781,0.695",-0.123]
[22419,"ENSG00000161203.13","AP2M1","chr3","+",184181084,184181226,184181695,184181815,184180848,184180984,184181911,184182047,22419,31142863,20301934,19281967,13281275,291,269,0.950866920684,1,"0.586,0.578","0.573,0.588",1E-3]
[22482,"ENSG00000103657.13","HERC1","chr15","-",63665918,63666150,63666355,63666472,63664469,63664594,63669537,63669698,22482,"133,78",221209,"108,57",173190,266,298,0.71806334809,0.871222278105416,"0.403,0.295","0.412,0.252",0.017]
[22524,"ENSG00000125107.17","CNOT1","chr16","-",58576462,58576582,58578698,58578939,58575006,58575129,58580632,58580760,22524,785710,583594,607563,463453,298,269,0.960497681836,1,"0.549,0.519","0.542,0.529",-2E-3]
[22569,"ENSG00000089053.12","ANAPC5","chr12","-",121309700,121309863,121318276,121318404,121308356,121308691,121318500,121318608,22569,"22,11",20151957,"19,13",10981299,277,298,0.232911076745,0.401663902324307,"0.012,0.006","0.018,0.011",-0.005]
[22586,"ENSG00000130783.13","CCDC62","chr12","+",122798084,122798200,122801123,122801852,122797306,122797395,122806150,122806295,22586,"3,11","13,7","1,1","7,10",265,298,0.00975162560736,0.0306061287570571,"0.206,0.639","0.138,0.101",0.303]
[22653,"ENSG00000184967.6","NOC4L","chr12","+",132147632,132147782,132147879,132147979,132147280,132147388,132148071,132148106,22653,362360,321336,297326,174260,298,249,0.0434462426239,0.107321198935401,"0.485,0.472","0.588,0.512",-0.072]
[22717,"ENSG00000141084.10","RANBP10","chr16","-",67734857,67735042,67738012,67738035,67731028,67731584,67744287,67744455,22717,"15,9","98,95","11,12",135120,172,298,0.331395234121,0.519182785906062,"0.21,0.141","0.124,0.148",0.039]
[22735,"ENSG00000132952.11","USPL1","chr13","+",30630834,30631474,30637743,30637857,30621763,30621892,30642627,30642757,22735,97113,94144,130115,102107,298,263,0.101132068037,0.212624160872841,"0.477,0.409","0.529,0.487",-0.065]
[22787,"ENSG00000174032.16","SLC25A30","chr13","-",45408926,45409074,45411361,45411480,45405882,45405977,45418299,45418380,22787,"20,30","55,56","11,6","48,28",268,297,0.0249186483388,0.067956925540053,"0.287,0.373","0.203,0.192",0.132]
[22819,"ENSG00000136104.20","RNASEH2B","chr13","+",50927406,50927478,50929474,50929582,50910109,50910140,50934884,50934999,22819,436515,"0,0",338412,"3,10",221,257,0.562574396513,0.745839279870816,"1.0,1.0","0.992,0.98",0.014]
[22886,"ENSG00000136122.15","BORA","chr13","+",72737961,72738043,72743536,72743602,72731280,72731387,72744504,72744561,22886,"17,6","134,96","21,18",184204,231,215,0.955384976496,1,"0.106,0.055","0.096,0.076",-0.005]
[22916,"ENSG00000204843.12","DCTN1","chr2","-",74377431,74377466,74377647,74377726,74371536,74371728,74377999,74378245,22916,402414,442432,277291,219212,228,184,0.00714376218583,0.0235287588029044,"0.423,0.436","0.505,0.526",-0.086]
[22964,"ENSG00000161202.18","DVL3","chr3","+",184166876,184166975,184167579,184167711,184166605,184166673,184167897,184168065,22964,"1,1",308353,"3,5",264261,248,281,0.671143382436,0.835360107464795,"0.004,0.003","0.013,0.021",-0.014]
[23031,"ENSG00000198176.12","TFDP1","chr13","+",113623179,113623286,113631622,113631905,113585773,113585849,113633119,113633285,23031,141118,"18,15",224198,"11,11",256,298,0.00280057063544,0.0105139551558398,"0.901,0.902","0.96,0.954",-0.055]
[23048,"ENSG00000169062.14","UPF3A","chr13","+",114282836,114282943,114291488,114291544,114281924,114282127,114291633,114291792,23048,217306,217218,200173,164149,256,205,0.994580975529,1,"0.445,0.529","0.494,0.482",-1E-3]
[23102,"ENSG00000100462.15","PRMT5","chr14","-",22924631,22924709,22924878,22925040,22924478,22924537,22926132,22926296,23102,1053889,347299,652625,251308,298,227,0.025182788703,0.0685402235088556,"0.698,0.694","0.664,0.607",0.06]
[23134,"ENSG00000006042.11","TMEM98","chr17","+",32931326,32931402,32931474,32931659,32928203,32928237,32933173,32933305,23134,"6,6",88116,"0,0",101107,225,298,1.43269704522E-4,0.000744823459256089,"0.083,0.064","0.0,0.0",0.074]
[23196,"ENSG00000127314.17","RAP1B","chr12","+",68650399,68650468,68651994,68652051,68648698,68648781,68654111,68654252,23196,721698,594491,728736,548618,218,206,0.712151001074,0.866951337873528,"0.534,0.573","0.557,0.529",0.01]
[23233,"ENSG00000257621.7","PSMA3-AS1","chr14","-",58273978,58274135,58291634,58291707,58266888,58267393,58297954,58298122,23233,"80,82","20,24","93,77","5,3",222,298,{"v":3.42147883914e-07,"d":"3.42E-07"},{"v":2.8557655288498e-06,"d":"2.86E-06"},"0.843,0.821","0.961,0.972",-0.134]
[23281,"ENSG00000230453.9","ANKRD18B","chr9","+",33539448,33539502,33540077,33540212,33536877,33536945,33541146,33541227,23281,"28,26","52,68","21,11","52,57",203,284,0.153176712297,0.293562568116794,"0.43,0.348","0.361,0.213",0.102]
[23347,"ENSG00000119720.17","NRDE2","chr14","-",90316577,90316811,90318004,90318113,90312393,90312543,90331840,90332137,23347,"49,54",92110,"51,43","68,62",258,298,0.0916990511321,0.196526705445169,"0.381,0.362","0.464,0.445",-0.083]
[23366,"ENSG00000063245.14","EPN1","chr19","+",55685395,55685645,55691753,55692057,55678526,55678855,55692685,55692796,23366,11231062,396358,616614,268355,298,298,0.00152701057277,0.00621264579123025,"0.739,0.748","0.697,0.634",0.078]
[23431,"ENSG00000126214.21","KLC1","chr14","+",103687080,103687211,103692358,103692425,103679383,103679518,103693552,103693743,23431,"19,22","91,75","42,43","44,35",280,216,{"v":1.98071559154e-09,"d":"1.98E-09"},{"v":2.23236833489095e-08,"d":"2.23E-08"},"0.139,0.185","0.424,0.487",-0.293]
[23455,"ENSG00000134755.15","DSC2","chr18","-",31071604,31071841,31074682,31074907,31070725,31070850,31079846,31079989,23455,269257,254221,193176,170124,298,298,0.361974752749,0.552715645227134,"0.514,0.538","0.532,0.587",-0.033]
[23498,"ENSG00000166439.5","RNF169","chr11","+",74817595,74817714,74834675,74834775,74810183,74810330,74835545,74842413,23498,153107,128146,135113,162130,268,249,0.607110020125,0.781907316415718,"0.526,0.405","0.436,0.447",0.024]
[23580,"ENSG00000104133.14","SPG11","chr15","-",44613429,44613536,44615362,44615566,44610839,44610985,44620189,44620403,23580,"106,98",152146,"95,94","73,75",298,256,3.07193455675E-4,1.48055121311917E-3,"0.375,0.366","0.528,0.518",-0.153]
[23602,"ENSG00000092439.14","TRPM7","chr15","-",50575868,50575919,50578638,50578664,50575723,50575789,50580873,50580908,23602,129130,"125,97","73,66","71,90",175,200,0.109517752687,0.22592309815683,"0.541,0.605","0.54,0.456",0.075]
[23669,"ENSG00000128915.11","ICE2","chr15","-",60442415,60442545,60448847,60449841,60436142,60436227,60453602,60453784,23669,284292,317287,288278,389296,298,279,0.283655192901,0.464909805915279,"0.456,0.488","0.409,0.468",0.033]
[23681,"ENSG00000140455.16","USP3","chr15","+",63558105,63558188,63562894,63563008,63556666,63556748,63570432,63570579,23681,152221,"120,76",168151,149149,232,263,0.0163613837584,0.047669078276386,"0.589,0.767","0.561,0.535",0.13]
[23682,"ENSG00000140455.16","USP3","chr15","+",63570432,63570579,63574045,63574152,63562894,63563008,63574322,63574403,23682,154107,171146,197192,147168,296,256,6.12601642966E-3,0.0206056082571902,"0.438,0.388","0.537,0.497",-0.104]
[23683,"ENSG00000028203.17","VEZT","chr12","+",95224179,95224236,95242163,95242264,95217811,95217886,95251939,95252071,23683,"11,0","7,6","5,2","2,0",206,250,5.22730514103E-3,0.0180473754169949,"0.656,0.0","0.752,1.0",-0.548]
[23684,"ENSG00000028203.17","VEZT","chr12","+",95256549,95256622,95257149,95257239,95251939,95252071,95262905,95263081,23684,"75,84",211212,"69,60",293294,222,239,0.00129147923151,5.37076565848569E-3,"0.277,0.299","0.202,0.18",0.097]
[23685,"ENSG00000028203.17","VEZT","chr12","+",95256549,95256622,95257153,95257239,95251939,95252071,95262905,95263081,23685,"75,84",109122,"69,60",143146,222,235,0.014378401541,0.0426718140568919,"0.421,0.422","0.338,0.303",0.101]
[23686,"ENSG00000028203.17","VEZT","chr12","+",95257149,95257239,95262905,95263081,95256549,95256622,95266356,95266632,23686,"58,58",261298,"69,72",262277,239,298,0.174975413938,0.324650914597268,"0.217,0.195","0.247,0.245",-0.04]
[23687,"ENSG00000028203.17","VEZT","chr12","+",95287663,95287857,95294271,95294372,95282312,95282359,95296050,95296258,23687,"2,4",271198,"6,2",244271,298,250,0.704446270195,0.860836637026782,"0.006,0.017","0.02,0.006",-2E-3]
[23688,"ENSG00000028203.17","VEZT","chr12","+",95287663,95287857,95294271,95294372,95282312,95282644,95296050,95296258,23688,294266,275200,279280,260288,298,250,0.256455843499,0.432176963789884,"0.473,0.527","0.474,0.449",0.038]
[23689,"ENSG00000198586.13","TLK1","chr2","-",171014850,171014948,171028338,171028405,171011372,171011454,171046173,171046362,23689,238204,234213,181192,206220,216,247,0.388303790115,0.579528253742539,"0.538,0.523","0.501,0.499",0.03]
[23690,"ENSG00000198586.13","TLK1","chr2","-",171022871,171023129,171028338,171028405,171014850,171014948,171046173,171046362,23690,650531,"7,10",549536,"20,30",216,298,{"v":2.79884059589e-05,"d":"2.80E-05"},0.000170564549360055,"0.992,0.987","0.974,0.961",0.022]
[23691,"ENSG00000198586.13","TLK1","chr2","-",171022871,171023129,171028338,171028405,171014850,171014948,171049813,171049950,23691,241159,"7,10",199188,"16,30",216,298,0.000335556102492,1.60212708603755E-3,"0.979,0.956","0.945,0.896",0.047]
[23692,"ENSG00000198586.13","TLK1","chr2","-",171022871,171023129,171046173,171046362,171014850,171014948,171049813,171049950,23692,436448,"7,10",446375,"16,30",298,298,0.000135412999837,0.000708866635336025,"0.984,0.978","0.965,0.926",0.035]
[23693,"ENSG00000198586.13","TLK1","chr2","-",171028338,171028405,171046173,171046362,171014850,171014948,171049813,171049950,23693,436448,241159,446375,199188,298,216,0.719807455887,0.872539293741078,"0.567,0.671","0.619,0.591",0.014]
[23694,"ENSG00000198586.13","TLK1","chr2","-",171028338,171028405,171046173,171046362,171022871,171023129,171049813,171049950,23694,435446,"15,11",430365,"26,32",298,216,0.000243949587467,0.00120309554012204,"0.955,0.967","0.923,0.892",0.053]
[23695,"ENSG00000198586.13","TLK1","chr2","-",171050063,171050174,171053760,171053853,171049813,171049950,171055082,171055172,23695,280277,339378,223212,290318,242,260,0.527333218599,0.7149369509866,"0.47,0.441","0.452,0.417",0.021]
[23696,"ENSG00000198586.13","TLK1","chr2","-",171082780,171082852,171117738,171117857,171061080,171061156,171160289,171160564,23696,234252,129129,302305,135150,268,221,0.395684054007,0.587305126799001,"0.599,0.617","0.648,0.626",-0.029]
[23697,"ENSG00000169118.17","CSNK1G1","chr15","-",64216561,64216713,64251511,64251581,64214082,64214124,64300318,64300723,23697,"1,0","60,46","4,14","89,65",219,298,{"v":3.74529409642e-05,"d":"3.75E-05"},0.000222098213387334,"0.022,0.0","0.058,0.227",-0.132]
[23698,"ENSG00000249240.2","AC069368.1","chr15","+",64859893,64859998,64921920,64922019,64854920,64855037,64930821,64930920,23698,247172,"1,0",247270,"6,13",254,248,0.000479348544371,0.00220797098062156,"0.996,1.0","0.976,0.953",0.034]
[23699,"ENSG00000166839.16","ANKDD1A","chr15","+",64942466,64942565,64943483,64943582,64934135,64934234,64944651,64944747,23699,"10,3","12,8","5,7","4,6",248,248,0.219567126451,0.384794771408433,"0.455,0.273","0.556,0.538",-0.183]
[23700,"ENSG00000166839.16","ANKDD1A","chr15","+",64943483,64943582,64944651,64944747,64942466,64942565,64947403,64947593,23700,"4,3","9,20","7,7","7,10",248,245,0.0238177239031,0.0655192012019121,"0.305,0.129","0.497,0.409",-0.236]
[23701,"ENSG00000166855.9","CLPX","chr15","-",65152429,65152536,65153546,65153639,65148218,65150913,65154781,65155081,23701,433336,177189,187184,125146,242,256,0.00388774527556,0.013989198768997,"0.721,0.653","0.613,0.571",0.095]
[23702,"ENSG00000166855.9","CLPX","chr15","-",65158574,65158751,65164028,65164188,65157745,65157910,65166630,65166785,23702,492432,449420,245195,258226,298,298,0.220158904227,0.385441048704726,"0.523,0.507","0.487,0.463",0.04]
[23703,"ENSG00000166855.9","CLPX","chr15","-",65158686,65158751,65164028,65164188,65157745,65157910,65166630,65166785,23703,492432,"0,3",245195,"7,2",298,214,0.0761135588127,0.16932629237253,"1.0,0.99","0.962,0.986",0.021]
[23704,"ENSG00000166855.9","CLPX","chr15","-",65162603,65162645,65164028,65164188,65158574,65158751,65166630,65166785,23704,492433,167129,257209,"58,50",298,191,0.042421639671,0.105311216635476,"0.654,0.683","0.74,0.728",-0.065]
[23705,"ENSG00000089597.17","GANAB","chr11","-",62629587,62629684,62630378,62630505,62629193,62629295,62630600,62630836,23705,13791523,590776,11151149,575616,276,246,0.293472086685,0.476378002869907,"0.676,0.636","0.633,0.624",0.027]
[23706,"ENSG00000089597.17","GANAB","chr11","-",62629813,62629957,62630196,62630276,62629587,62629684,62630378,62630505,23706,1033922,18261873,846836,12051345,229,293,0.0391192314224,0.0987052230016738,"0.42,0.386","0.473,0.443",-0.055]
[23707,"ENSG00000089597.17","GANAB","chr11","-",62629813,62629957,62630378,62630505,62629587,62629684,62630600,62630836,23707,13791523,18261871,11161149,12061341,276,293,0.236844147955,0.406729682085057,"0.445,0.464","0.496,0.476",-0.031]
[23708,"ENSG00000089597.17","GANAB","chr11","-",62630196,62630276,62630378,62630505,62629813,62629957,62630600,62630836,23708,13791525,749595,11141153,447593,276,229,0.923440597861,1,"0.604,0.68","0.674,0.617",-0.003]
[23709,"ENSG00000089597.17","GANAB","chr11","-",62631029,62631183,62632564,62632745,62630600,62630836,62633004,62633101,23709,12661170,18541810,9831038,13771346,298,298,0.305877335855,0.491016493486175,"0.406,0.393","0.417,0.435",-0.026]
[23710,"ENSG00000089597.17","GANAB","chr11","-",62633183,62633271,62633444,62633514,62633004,62633101,62634820,62635000,23710,728748,13951320,232225,10721069,219,237,{"v":9.99200722163e-16,"d":"9.99E-16"},{"v":2.2010824535569e-14,"d":"2.20E-14"},"0.361,0.38","0.19,0.186",0.182]
[23711,"ENSG00000074696.12","HACD3","chr15","+",65556738,65556903,65558679,65558731,65554886,65554960,65562773,65562884,23711,654644,289374,643681,349366,298,201,0.620299801921,0.793617825382242,"0.604,0.537","0.554,0.557",0.015]
[23712,"ENSG00000074696.12","HACD3","chr15","+",65558679,65558731,65562773,65562884,65556738,65556903,65564214,65564342,23712,282296,354364,235319,392347,201,260,0.623170862839,0.79629356899053,"0.507,0.513","0.437,0.543",0.02]
[23713,"ENSG00000074696.12","HACD3","chr15","+",65562773,65562884,65564214,65564342,65558679,65558731,65570090,65570199,23713,582548,475542,543637,469430,260,277,0.164532664005,0.310101709637214,"0.566,0.519","0.552,0.612",-0.04]
[23714,"ENSG00000166938.12","DIS3L","chr15","+",66323492,66323585,66325830,66326364,66322686,66322934,66328969,66329124,23714,116129,156130,"56,46","69,74",242,298,0.326608276575,0.514251423173523,"0.478,0.55","0.5,0.434",0.047]
[23716,"ENSG00000128973.12","CLN6","chr15","-",68209636,68209759,68211262,68211318,68208115,68208410,68218535,68218650,23716,"0,3",883994,"2,0",496426,205,272,1,1,"0.0,0.004","0.005,0.0",-1E-3]
[23717,"ENSG00000128973.12","CLN6","chr15","-",68211262,68211318,68218535,68218650,68209636,68209759,68229501,68229510,23717,460576,244303,297278,"154,96",264,205,0.174434610487,0.323888212795008,"0.594,0.596","0.6,0.692",-0.051]
[23718,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211643,68211648,68211863,68211262,68211318,68214289,68214388,23718,794810,"25,29",340319,"94,36",298,237,{"v":1.80189196897e-13,"d":"1.80E-13"},{"v":3.16797422932605e-12,"d":"3.17E-12"},"0.962,0.957","0.742,0.876",0.151]
[23719,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211643,68211674,68211863,68211262,68211318,68214289,68214388,23719,15531495,"25,29",691699,"94,36",298,237,{"v":1.11022302463e-16,"d":"1.11E-16"},{"v":2.67083523987274e-15,"d":"2.67E-15"},"0.98,0.976","0.854,0.939",0.082]
[23720,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211643,68211674,68211921,68211262,68211318,68214289,68214388,23720,765694,"25,29",353382,"94,36",298,237,{"v":3.83225895462e-10,"d":"3.83E-10"},{"v":4.74418878519872e-09,"d":"4.74E-09"},"0.961,0.95","0.749,0.894",0.134]
[23721,"ENSG00000128973.12","CLN6","chr15","-",68211674,68211863,68214289,68214388,68211262,68211318,68218535,68218650,23721,421441,781707,233202,364389,248,298,0.969986000394,1,"0.393,0.428","0.435,0.384",1E-3]
[23722,"ENSG00000128973.12","CLN6","chr15","-",68211674,68211863,68218535,68218650,68211262,68211318,68229501,68229677,23722,458588,765696,304278,353382,264,298,0.440447274231,0.632035635888297,"0.403,0.488","0.493,0.451",-0.026]
[23723,"ENSG00000166716.9","ZNF592","chr15","+",84764706,84764815,84778182,84778312,84748634,84748664,84782656,84784895,23723,178167,200160,"70,67",168177,258,279,{"v":2.51398268869e-08,"d":"2.51E-08"},{"v":2.46990279983277E-7,"d":"2.47E-07"},"0.49,0.53","0.311,0.29",0.21]
[23724,"ENSG00000138604.9","GLCE","chr15","+",69210315,69210406,69255793,69256392,69160633,69160757,69261086,69261329,23724,"18,29","120,68","23,38",156128,240,298,0.598154148378,0.775036836179721,"0.157,0.346","0.155,0.269",0.039]
[23725,"ENSG00000198612.10","COPS8","chr2","+",237088604,237088653,237094089,237094197,237087126,237087197,237095821,237095884,23725,222252,736640,107176,400365,198,257,0.793711763279,0.92687020472511,"0.281,0.338","0.258,0.385",-0.012]
[23726,"ENSG00000198612.10","COPS8","chr2","+",237089861,237089994,237094089,237094197,237088604,237088653,237095821,237095884,23726,344390,737651,266247,429400,282,257,0.206996529918,0.368250596257129,"0.298,0.353","0.361,0.36",-0.035]
[23727,"ENSG00000198612.10","COPS8","chr2","+",237096821,237096869,237097662,237097802,237095821,237095884,237098957,237099143,23727,282256,"17,42",149164,"18,13",197,289,0.620089611802,0.793445144549904,"0.961,0.899","0.924,0.949",-0.007]
[23728,"ENSG00000137819.13","PAQR5","chr15","+",69397467,69397564,69399973,69400115,69389653,69389780,69403580,69404504,23728,"2,3","2,9","2,3","27,28",246,291,0.0706147842355,0.1593655671944,"0.542,0.283","0.081,0.112",0.316]
[23729,"ENSG00000005007.12","UPF1","chr19","+",18856876,18857020,18857319,18857533,18856185,18856300,18860320,18860438,23729,487518,557593,401398,551463,293,298,0.396656753162,0.588243719015047,"0.471,0.47","0.425,0.466",0.025]
[23730,"ENSG00000137831.14","UACA","chr15","-",70682757,70682795,70687539,70687646,70679607,70679676,70687749,70687820,23730,"70,91","6,12","37,47","4,2",256,187,0.21995088354,0.385196913660191,"0.895,0.847","0.871,0.945",-0.037]
[23731,"ENSG00000137831.14","UACA","chr15","-",70684264,70684446,70687539,70687646,70682757,70682795,70687749,70687820,23731,"67,91","71,70","50,52","26,19",256,298,0.00249933458508,0.00950534001221437,"0.523,0.602","0.691,0.761",-0.163]
[23732,"ENSG00000145020.15","AMT","chr3","-",49418970,49419151,49419259,49419335,49417817,49417973,49419709,49419788,23732,"0,0","30,17","0,1","20,22",225,298,1,1,"0.0,0.0","0.0,0.057",-0.029]
[23733,"ENSG00000145020.15","AMT","chr3","-",49418970,49419151,49419259,49419393,49417817,49417973,49419709,49419788,23733,"0,0","30,17","1,1","20,22",283,298,0.267806567592,0.445663291899322,"0.0,0.0","0.05,0.046",-0.048]
[23734,"ENSG00000145020.15","AMT","chr3","-",49418970,49419151,49419259,49421572,49417817,49417973,49422103,49422271,23734,"8,8","29,14","4,7","20,22",298,298,0.406357876021,0.597503770454541,"0.216,0.364","0.167,0.241",0.086]
[23735,"ENSG00000145020.15","AMT","chr3","-",49418970,49419151,49420210,49420342,49417817,49417973,49422103,49422271,23735,"1,0","29,14","0,0","20,22",281,298,1,1,"0.035,0.0","0.0,0.0",0.018]
[23736,"ENSG00000145020.15","AMT","chr3","-",49419709,49419788,49420210,49420342,49417817,49417973,49421491,49421572,23736,"16,15","0,0","27,49","0,1",281,228,1,1,"1.0,1.0","1.0,0.975",0.012]
[23737,"ENSG00000145020.15","AMT","chr3","-",49420210,49420342,49421491,49421572,49419709,49419788,49422103,49422271,23737,"8,8","10,5","3,6","17,27",230,281,0.0010185042157,0.00435319977602497,"0.494,0.662","0.177,0.214",0.383]
[23738,"ENSG00000145020.15","AMT","chr3","-",49421491,49421572,49422103,49422271,49420210,49420342,49422360,49422473,23738,"2,0","9,7","1,1","15,30",298,230,0.389969968827,0.581281360592667,"0.146,0.0","0.049,0.025",0.036]
[23743,"ENSG00000093000.18","NUP50","chr22","+",45181285,45181367,45183401,45183520,45178237,45178900,45184452,45184830,23743,517394,928933,416423,824857,231,268,0.827239905088,0.949783006000116,"0.393,0.329","0.369,0.364",-0.006]
[23744,"ENSG00000125676.19","THOC2","chrX","-",123668158,123668314,123671668,123671761,123667105,123667278,123686547,123686714,23744,225285,432424,103151,247245,242,298,0.337730786149,0.526100459926641,"0.391,0.453","0.339,0.431",0.037]
[23745,"ENSG00000125676.19","THOC2","chrX","-",123671668,123671761,123686547,123686714,123668158,123668314,123696020,123696154,23745,460406,318346,196175,186165,298,242,0.120394324516,0.243224247217227,"0.54,0.488","0.461,0.463",0.052]
[23746,"ENSG00000125676.19","THOC2","chrX","-",123671668,123671761,123706857,123706949,123668158,123668314,123712849,123712908,23746,204166,318346,155134,184161,241,242,0.00485382754156,0.0169138726785532,"0.392,0.325","0.458,0.455",-0.098]
[23747,"ENSG00000125676.19","THOC2","chrX","-",123686547,123686714,123696020,123696154,123671668,123671761,123696720,123696835,23747,416437,434482,184167,218267,283,298,0.0682457258452,0.154905870695605,"0.502,0.488","0.471,0.397",0.061]
[23748,"ENSG00000125676.19","THOC2","chrX","-",123686547,123686714,123703453,123703505,123671668,123671761,123706857,123706949,23748,"89,88",437483,"31,35",219270,201,298,0.0443875587441,0.109142488227312,"0.232,0.213","0.173,0.161",0.056]
[23749,"ENSG00000125676.19","THOC2","chrX","-",123686547,123686714,123706857,123706949,123671668,123671761,123712849,123712908,23749,204166,433482,177145,220267,241,298,0.00252541427942,0.00958829561410746,"0.368,0.299","0.499,0.402",-0.117]
[23750,"ENSG00000125676.19","THOC2","chrX","-",123686547,123686714,123712849,123712908,123671668,123671761,123732951,123733037,23750,"2,2",433482,"5,6",218269,208,298,0.0163030881743,0.0475300490707599,"0.007,0.006","0.032,0.031",-0.025]
[23751,"ENSG00000125676.19","THOC2","chrX","-",123696020,123696154,123696720,123696835,123686547,123686714,123697680,123697687,23751,"1,0",432385,"0,0",186164,264,283,1,1,"0.002,0.0","0.0,0.0",1E-3]
[23752,"ENSG00000125676.19","THOC2","chrX","-",123696020,123696154,123696720,123696842,123686547,123686714,123697680,123697751,23752,324350,432385,122114,186164,271,283,0.148605443243,0.286832377306671,"0.439,0.487","0.407,0.421",0.049]
[23753,"ENSG00000125676.19","THOC2","chrX","-",123696020,123696154,123703453,123703505,123686547,123686714,123706857,123706949,23753,"89,89",432385,"31,35",186164,201,283,0.398631652339,0.590237535183195,"0.225,0.246","0.19,0.231",0.025]
[23754,"ENSG00000125676.19","THOC2","chrX","-",123696720,123696835,123697680,123697751,123696020,123696154,123703453,123703505,23754,322248,383387,90103,162140,220,264,0.349743889806,0.539539681431583,"0.502,0.435","0.4,0.469",0.034]
[23755,"ENSG00000125676.19","THOC2","chrX","-",123696720,123696842,123697680,123697751,123696020,123696154,123703453,123703505,23755,322248,392393,90103,166146,220,271,0.2926698355,0.475483150757205,"0.503,0.437","0.4,0.465",0.037]
[23756,"ENSG00000125676.19","THOC2","chrX","-",123697680,123697751,123703453,123703505,123696720,123696835,123706857,123706949,23756,"89,86","0,0","31,36","3,14",201,220,{"v":9.1231942001e-09,"d":"9.12E-09"},{"v":9.45957777951301e-08,"d":"9.46E-08"},"1.0,1.0","0.919,0.738",0.171]
[23757,"ENSG00000125676.19","THOC2","chrX","-",123697680,123697751,123703453,123703505,123696720,123696842,123706857,123706949,23757,"89,86",196250,"33,36","87,93",201,220,0.853393371082,0.968331299658954,"0.332,0.274","0.293,0.298",0.008]
[23758,"ENSG00000125676.19","THOC2","chrX","-",123697680,123697751,123706857,123706949,123696720,123696842,123712849,123712908,23758,204166,196250,156144,"76,77",241,220,{"v":3.59652394777e-06,"d":"3.60E-06"},{"v":2.55728786653304e-05,"d":"2.56E-05"},"0.487,0.377","0.652,0.631",-0.209]
[23759,"ENSG00000140463.13","BBS4","chr15","+",72697991,72698037,72704423,72704481,72695176,72695228,72709699,72709779,23759,"0,0","2,0","0,3","0,0",195,207,1,1,"0.0,NA","NA,1.0",-1]
[23760,"ENSG00000140463.13","BBS4","chr15","+",72727939,72727994,72729615,72729684,72724527,72724655,72731304,72731457,23760,"60,27","36,39","29,36","42,35",204,218,0.44520413009,0.636584676020886,"0.64,0.425","0.425,0.524",0.058]
[23761,"ENSG00000067141.16","NEO1","chr15","+",73273810,73274005,73278130,73278199,73272454,73272562,73282963,73283111,23761,159140,"83,86",125176,"104,57",298,218,0.790633683785,0.924648817777531,"0.584,0.544","0.468,0.693",-0.016]
[23762,"ENSG00000067141.16","NEO1","chr15","+",73298347,73298611,73301320,73301457,73289145,73289238,73302612,73302718,23762,"8,4","113,82","36,21","116,91",298,286,{"v":7.85148604798e-07,"d":"7.85E-07"},{"v":6.24478017741814e-06,"d":"6.24E-06"},"0.064,0.045","0.229,0.181",-0.151]
[23763,"ENSG00000156642.16","NPTN","chr15","-",73570149,73570423,73573661,73573795,73563235,73563257,73633124,73633245,23763,"8,13",668596,92133,513457,283,298,0,0,"0.012,0.022","0.159,0.235",-0.18]
[23764,"ENSG00000156642.16","NPTN","chr15","-",73587523,73587618,73591965,73592069,73573661,73573795,73633124,73633227,23764,"6,10",475390,"59,40",197147,253,244,0,0,"0.012,0.024","0.224,0.208",-0.198]
[23765,"ENSG00000156642.16","NPTN","chr15","-",73587523,73587618,73591965,73592137,73573661,73573795,73633124,73633243,23765,274291,475390,178189,197147,298,244,0.001175053062,0.00493777206846418,"0.321,0.379","0.425,0.513",-0.119]
[23766,"ENSG00000103653.16","CSK","chr15","+",74800411,74800505,74800680,74800746,74799177,74799491,74800822,74800922,23766,14121594,402377,9731008,349426,243,215,0.000444053044322,0.00206486503577628,"0.757,0.789","0.712,0.677",0.079]
[23767,"ENSG00000140474.13","ULK3","chr15","-",74838151,74838192,74838265,74838344,74837750,74837798,74838439,74838504,23767,244225,156168,131154,224226,228,190,{"v":8.52696768749e-09,"d":"8.53E-09"},{"v":8.88235683682025e-08,"d":"8.88E-08"},"0.566,0.527","0.328,0.362",0.202]
[23768,"ENSG00000140474.13","ULK3","chr15","-",74839267,74839373,74839557,74839713,74839009,74839050,74840233,74840316,23768,418484,272204,306267,140200,298,255,0.567458851782,0.749484654402172,"0.568,0.67","0.652,0.533",0.026]
[23769,"ENSG00000140474.13","ULK3","chr15","-",74839557,74839713,74840233,74840316,74839267,74839373,74840497,74840641,23769,179132,361395,"66,98",204311,232,298,0.127564854426,0.254371202884078,"0.389,0.3","0.294,0.288",0.054]
[23770,"ENSG00000140497.16","SCAMP2","chr15","-",74848599,74848645,74850513,74850673,74845472,74845593,74851352,74851481,23770,903898,712692,639649,446470,298,195,0.424124412415,0.616553911037295,"0.454,0.459","0.484,0.475",-0.023]
[23771,"ENSG00000140497.16","SCAMP2","chr15","-",74848599,74848701,74850513,74850673,74843731,74845593,74851352,74851481,23771,903898,10661094,639649,678704,298,251,0.321413419753,0.508365347629885,"0.416,0.409","0.443,0.437",-0.028]
[23772,"ENSG00000140497.16","SCAMP2","chr15","-",74852068,74852186,74854020,74854119,74851352,74851481,74854580,74854586,23772,640679,453614,734855,483485,248,267,0.018178784025,0.0521992457837348,"0.603,0.544","0.621,0.655",-0.065]
[23773,"ENSG00000140497.16","SCAMP2","chr15","-",74852068,74852186,74854020,74854119,74851352,74851481,74873198,74873310,23773,"0,0",453614,"9,0",483486,248,267,0.844235797064,0.96192363713139,"0.0,0.0","0.02,0.0",-0.01]
[23774,"ENSG00000178761.14","FAM219B","chr15","-",74904663,74904712,74905153,74905231,74902603,74902783,74906277,74906341,23774,"53,51","14,21","54,86","11,21",227,198,0.195639729251,0.352752419391706,"0.768,0.679","0.811,0.781",-0.073]
[23775,"ENSG00000178761.14","FAM219B","chr15","-",74905153,74905231,74906277,74906365,74904663,74904712,74906586,74906883,23775,"96,79",214216,125116,244259,237,227,0.284684321332,0.466120528747993,"0.301,0.259","0.329,0.3",-0.034]
[23776,"ENSG00000139154.14","AEBP2","chr12","+",19514670,19514784,19518086,19518113,19512397,19512465,19552852,19553272,23776,160135,"0,1","101,89","3,0",263,176,0.45979889466,0.650703619330827,"1.0,0.989","0.958,1.0",0.015]
[23777,"ENSG00000140400.16","MAN2C1","chr15","-",75356300,75356449,75356605,75356685,75356109,75356219,75356792,75356902,23777,243278,370401,119135,306303,229,298,0.000400629085814,0.00188084724804738,"0.461,0.474","0.336,0.367",0.116]
[23778,"ENSG00000140400.16","MAN2C1","chr15","-",75358200,75358344,75358461,75358618,75356792,75356902,75358703,75358808,23778,276278,280299,204244,127147,298,293,1.14497490865E-4,0.000609920370375933,"0.492,0.478","0.612,0.62",-0.131]
[23779,"ENSG00000140400.16","MAN2C1","chr15","-",75358200,75358344,75359327,75359425,75356792,75356902,75359619,75359680,23779,229258,281300,128150,113136,247,293,0.0481197860246,0.116594634196665,"0.492,0.505","0.573,0.567",-0.071]
[23780,"ENSG00000140400.16","MAN2C1","chr15","-",75358200,75358344,75359327,75359438,75356792,75356902,75359619,75359775,23780,"10,22",281300,"8,10",113136,260,293,0.51832912301,0.705838609994647,"0.039,0.076","0.074,0.077",-0.018]
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[59,"ENSG00000204165.5","CXorf65","chrX","-",71106339,71106426,71106358,71106426,71105999,71106137,59,"13,8","2,7","0,0","2,0",168,149,1,1,"0.852,0.503","0.0,NA",0.677]
[62,"ENSG00000204271.12","SPIN3","chrX","-",56995215,56995530,56995241,56995530,56994722,56994949,62,"11,10","2,7","27,39","14,12",175,149,0.946771758495,1,"0.824,0.549","0.622,0.735",0.008]
[63,"ENSG00000204271.12","SPIN3","chrX","-",56995215,56995555,56995280,56995555,56994722,56994949,63,"17,20","0,2","46,56","6,18",214,149,0.00183256021462,0.00897754225358923,"1.0,0.874","0.842,0.684",0.174]
[64,"ENSG00000204271.12","SPIN3","chrX","-",56995241,56995555,56995280,56995555,56994722,56994949,64,"8,17","0,2","33,29","6,18",188,149,2.38258962543E-3,0.0112816457704119,"1.0,0.871","0.813,0.561",0.248]
[65,"ENSG00000234068.6","PAGE2","chrX","+",55090501,55090610,55090501,55090559,55091331,55091457,65,"4,2","0,1","10,14","0,0",200,149,1,1,"1.0,0.598","1.0,1.0",-0.201]
[68,"ENSG00000086758.15","HUWE1","chrX","-",53543840,53543968,53543885,53543968,53542442,53542539,68,699665,433402,244292,"83,83",194,149,{"v":9.79208369611e-07,"d":"9.79E-07"},{"v":1.00518355346136E-5,"d":"1.01E-05"},"0.554,0.56","0.693,0.73",-0.154]
[69,"ENSG00000086758.15","HUWE1","chrX","-",53602563,53602658,53602590,53602658,53595186,53595403,69,179140,"0,0",134135,"2,0",176,149,1,1,"1.0,1.0","0.983,1.0",0.008]
[70,"ENSG00000086758.15","HUWE1","chrX","-",53602563,53602658,53602590,53602658,53600117,53600309,70,575475,"34,38",398463,"10,8",176,149,{"v":3.25316461969e-06,"d":"3.25E-06"},{"v":3.03798133495008e-05,"d":"3.04E-05"},"0.935,0.914","0.971,0.98",-0.051]
[71,"ENSG00000072506.12","HSD17B10","chrX","-",53431797,53431906,53431824,53431906,53431257,53431594,71,15971703,"39,30",11081333,"26,23",176,149,0.836061978316,1,"0.972,0.98","0.973,0.98",0]
[72,"ENSG00000072506.12","HSD17B10","chrX","-",53431973,53432116,53431987,53432116,53431858,53431906,72,"6,2",11231015,"10,11",780813,163,149,0.838072318467,1,"0.005,0.002","0.012,0.012",-0.009]
[73,"ENSG00000126012.11","KDM5C","chrX","-",53193772,53193851,53193781,53193851,53193436,53193636,73,270266,400366,244326,355341,158,149,0.284689797985,0.608401439555548,"0.389,0.407","0.393,0.474",-0.035]
[74,"ENSG00000268350.7","FAM156A","chrX","-",52995305,52995472,52995414,52995472,52947257,52948705,74,"0,0","0,1","4,0","0,1",258,149,1,1,"NA,0.0","1.0,0.0",-0.5]
[79,"ENSG00000269313.5","MAGIX","chrX","+",49164706,49165090,49164706,49164789,49165189,49165361,79,"14,23","17,5","8,12","15,14",298,149,0.088966406203,0.237729905099819,"0.292,0.697","0.211,0.3",0.239]
[80,"ENSG00000196998.17","WDR45","chrX","-",49076405,49076524,49076429,49076524,49075865,49075945,80,"0,3",136125,"4,1",99111,173,149,0.769378250734,1,"0.0,0.02","0.034,0.008",-0.011]
[83,"ENSG00000147144.12","CCDC120","chrX","+",49061958,49062104,49061958,49062058,49062234,49062325,83,"15,18","2,4","34,26","1,2",195,149,0.0551718940648,0.163060229766241,"0.851,0.775","0.963,0.909",-0.123]
[84,"ENSG00000147144.12","CCDC120","chrX","+",49061958,49062117,49061958,49062058,49062234,49062325,84,"50,59","2,4",130112,"1,2",208,149,0.0295042754357,0.097603627040978,"0.947,0.914","0.989,0.976",-0.052]
[86,"ENSG00000147144.12","CCDC120","chrX","+",49062234,49062325,49062234,49062289,49062467,49062601,86,"59,59","5,7",171128,"11,9",185,149,0.405107041262,0.785250729711098,"0.905,0.872","0.926,0.92",-0.034]
[87,"ENSG00000068308.13","OTUD5","chrX","-",48934695,48934867,48934710,48934867,48934463,48934612,87,"46,34",10061011,"34,48",657685,164,149,0.0248255297512,0.0849468985570641,"0.04,0.03","0.045,0.06",-0.017]
[88,"ENSG00000102100.15","SLC35A2","chrX","-",48904163,48905482,48904745,48905482,48903179,48903465,88,"28,35","70,46","71,85","2,8",298,149,0,0,"0.167,0.276","0.947,0.842",-0.673]
[89,"ENSG00000102100.15","SLC35A2","chrX","-",48909813,48909996,48909852,48909996,48906391,48906543,89,401319,"2,0",388365,"0,0",188,149,1,1,"0.994,1.0","1.0,1.0",-0.003]
[90,"ENSG00000102100.15","SLC35A2","chrX","-",48911468,48911646,48911506,48911646,48909813,48909996,90,"7,1","0,0","1,3","0,6",187,149,0.00192186994691,0.00936389351850442,"1.0,1.0","1.0,0.285",0.358]
[91,"ENSG00000102100.15","SLC35A2","chrX","-",48911468,48911646,48911545,48911646,48909813,48909996,91,"7,1",140126,"1,3",163154,226,149,0.435250262411,0.823210675635994,"0.032,0.005","0.004,0.013",0.01]
[92,"ENSG00000102100.15","SLC35A2","chrX","-",48911506,48911646,48911545,48911646,48909813,48909996,92,"0,0",140126,"0,6",163154,188,149,0.679024045035,1,"0.0,0.0","0.0,0.03",-0.015]
[94,"ENSG00000094631.19","HDAC6","chrX","+",48805630,48805779,48805630,48805671,48806367,48806464,94,"23,9",410312,"40,65","80,74",257,149,0,0,"0.031,0.016","0.225,0.337",-0.258]
[95,"ENSG00000094631.19","HDAC6","chrX","+",48805630,48806464,48805630,48805671,48806608,48806706,95,345328,"0,0",135147,"1,0",298,149,1,1,"1.0,1.0","0.985,1.0",0.008]
[96,"ENSG00000102317.17","RBM3","chrX","+",48575560,48575667,48575560,48575630,48576313,48576419,96,56005053,"8,1",51625857,"0,0",186,149,1,1,"0.998,1.0","1.0,1.0",-1E-3]
[97,"ENSG00000102317.17","RBM3","chrX","+",48575560,48576083,48575560,48575630,48576313,48576419,97,23382020,"8,1",21442499,"0,0",298,149,1,1,"0.993,0.999","1.0,1.0",-0.004]
[98,"ENSG00000102317.17","RBM3","chrX","+",48575560,48576083,48575560,48575667,48576313,48576419,98,173183,33693148,296255,32583577,298,149,0.0015071693866,7.63377036772259E-3,"0.025,0.028","0.043,0.034",-0.012]
[99,"ENSG00000102312.21","PORCN","chrX","+",48509423,48509707,48509423,48509577,48509783,48509956,99,"26,22","0,1","17,13","0,0",279,149,1,1,"1.0,0.922","1.0,1.0",-0.039]
[100,"ENSG00000147124.12","ZNF41","chrX","-",47467323,47467548,47467409,47467548,47456271,47456438,100,"8,5","6,1","1,8","10,38",235,149,0.000245975966926,1.52960083941613E-3,"0.458,0.76","0.06,0.118",0.52]
[101,"ENSG00000182872.15","RBM10","chrX","+",47179879,47180040,47179879,47180037,47180211,47180309,101,176173,188159,81114,134140,152,149,0.0275801161188,0.0926051464438359,"0.479,0.516","0.372,0.444",0.089]
[102,"ENSG00000251192.7","ZNF674","chrX","-",46528334,46528445,46528349,46528445,46499436,46501332,102,"0,0","3,0","4,6","3,0",164,149,1,1,"0.0,NA","0.548,1.0",-0.774]
[103,"ENSG00000147121.15","KRBOX4","chrX","+",46463197,46463308,46463197,46463293,46471141,46471185,103,"22,24","13,16","20,11","6,0",164,149,0.00904846729349,0.0357617234178418,"0.606,0.577","0.752,1.0",-0.285]
[104,"ENSG00000147121.15","KRBOX4","chrX","+",46463197,46463308,46463197,46463293,46472024,46472526,104,"3,6","0,2","10,11","0,0",164,149,0.78202727501,1,"1.0,0.732","1.0,1.0",-0.134]
[105,"ENSG00000147121.15","KRBOX4","chrX","+",46463197,46463308,46463197,46463293,46472752,46473594,105,"4,9","2,2","10,10","2,5",164,149,0.720459969385,1,"0.645,0.803","0.82,0.645",-0.008]
[107,"ENSG00000147044.21","CASK","chrX","-",41853096,41853227,41853114,41853227,41787177,41787283,107,"1,0","3,4","0,0","2,3",167,149,1,1,"0.229,0.0","0.0,0.0",0.115]
[113,"ENSG00000165195.15","PIGA","chrX","-",15331215,15331992,15331589,15331992,15325913,15326046,113,"53,38","2,1","58,65","7,3",298,149,0.0729677617751,0.204234517789125,"0.93,0.95","0.806,0.915",0.079]
[114,"ENSG00000165195.15","PIGA","chrX","-",15331215,15331992,15331819,15331992,15325913,15326046,114,"60,47","2,0","44,67","0,0",298,149,0.316300363844,0.656027590984124,"0.938,1.0","1.0,1.0",-0.031]
[115,"ENSG00000165195.15","PIGA","chrX","-",15331215,15331992,15331873,15331992,15325913,15326046,115,"59,56","10,18","49,67","3,0",298,149,{"v":2.65098489816E-6,"d":"2.65E-06"},{"v":2.5238314632217E-5,"d":"2.52E-05"},"0.747,0.609","0.891,1.0",-0.268]
[116,"ENSG00000165195.15","PIGA","chrX","-",15331589,15331992,15331819,15331992,15325913,15326046,116,"41,30","2,0","29,34","0,0",298,149,0.443780046164,0.832319689092104,"0.911,1.0","1.0,1.0",-0.044]
[117,"ENSG00000165195.15","PIGA","chrX","-",15331589,15331992,15331873,15331992,15325913,15326046,117,"40,39","10,18","34,34","3,0",298,149,{"v":2.76763930503E-5,"d":"2.77E-05"},0.000215131962742144,"0.667,0.52","0.85,1.0",-0.332]
[118,"ENSG00000165195.15","PIGA","chrX","-",15331819,15331992,15331873,15331992,15325913,15326046,118,"26,22","10,18","16,13","3,0",203,149,1.07986638263E-3,5.68912955158351E-3,"0.656,0.473","0.797,1.0",-0.334]
[119,"ENSG00000102048.15","ASB9","chrX","-",15248682,15248935,15248743,15248935,15236527,15236600,119,"22,21","2,0","8,6","1,2",210,149,0.151105927501,0.364974757084813,"0.886,1.0","0.85,0.68",0.178]
[120,"ENSG00000102048.15","ASB9","chrX","-",15248682,15248935,15248743,15248935,15243986,15244630,120,"60,58","22,20","14,7","1,0",210,149,{"v":5.4196046223e-05,"d":"5.42E-05"},0.000392356033154127,"0.659,0.673","0.909,1.0",-0.288]
[121,"ENSG00000046647.13","GEMIN8","chrX","-",14026051,14026221,14026139,14026221,14021463,14021511,121,"6,19",104111,"30,26","42,44",237,149,{"v":4.30744218072e-10,"d":"4.31E-10"},{"v":7.47410693228802e-09,"d":"7.47E-09"},"0.035,0.097","0.31,0.271",-0.224]
[123,"ENSG00000068438.14","FTSJ1","chrX","+",48481425,48481715,48481425,48481528,48482402,48482506,123,551509,"13,3",259364,"11,7",298,149,0.0837658643805,0.227794026543331,"0.955,0.988","0.922,0.963",0.029]
[124,"ENSG00000101871.14","MID1","chrX","-",10566887,10567603,10567001,10567603,10523091,10523187,124,"6,11","2,4","7,12","0,0",263,149,{"v":3.80704659826E-5,"d":"3.81E-05"},2.86407044084483E-4,"0.63,0.609","1.0,1.0",-0.381]
[126,"ENSG00000006757.11","PNPLA4","chrX","-",7927670,7927739,7927685,7927739,7922003,7922098,126,"3,1","1,2","0,0","0,1",164,149,1,1,"0.732,0.312","NA,0.0",0.522]
[127,"ENSG00000006757.11","PNPLA4","chrX","-",7927670,7927739,7927685,7927739,7925939,7926132,127,"37,25","14,5","16,30","4,7",164,149,0.605293208324,1,"0.706,0.82","0.784,0.796",-0.027]
[128,"ENSG00000130021.13","PUDP","chrX","-",7105619,7105838,7105748,7105838,7077219,7077449,128,350366,"3,0",217262,"1,0",278,149,1,1,"0.984,1.0","0.991,1.0",-0.004]
[129,"ENSG00000285756.1","BX890604.2","chrX","-",3828505,3829392,3829363,3829392,3818441,3818500,129,148154,"4,0",201195,"0,4",298,149,0.782335931894,1,"0.949,1.0","1.0,0.961",-0.006]
[130,"ENSG00000230590.9","FTX","chrX","-",74280376,74280494,74280393,74280494,74274341,74274410,130,"15,9","25,37","3,3","4,3",166,149,0.322683160147,0.664260512219943,"0.35,0.179","0.402,0.473",-0.173]
[131,"ENSG00000079974.17","RABL2B","chr22","-",50769424,50769549,50769454,50769549,50769040,50769124,131,"11,8","31,35","2,4","6,14",179,149,0.773740342146,1,"0.228,0.16","0.217,0.192",-0.011]
[132,"ENSG00000079974.17","RABL2B","chr22","-",50783038,50783286,50783044,50783286,50782187,50782351,132,"41,42","5,8","30,11","7,3",155,149,0.437785374215,0.82539345527602,"0.887,0.835","0.805,0.779",0.069]
[134,"ENSG00000254413.8","CHKB-CPT1B","chr22","-",50579726,50579830,50579790,50579830,50579425,50579507,134,620557,"0,3",415485,"0,0",213,149,1,1,"1.0,0.992","1.0,1.0",-0.004]
[135,"ENSG00000196576.14","PLXNB2","chr22","-",50294718,50294778,50294725,50294778,50289516,50290597,135,"42,32","20,30","22,32","5,12",156,149,0.0346968393684,0.111224254447332,"0.667,0.505","0.808,0.718",-0.177]
[136,"ENSG00000100429.17","HDAC10","chr22","-",50250973,50251405,50251101,50251405,50250770,50250905,136,260355,"29,49",190224,"29,33",277,149,0.425241089564,0.811124759136438,"0.828,0.796","0.779,0.785",0.03]
[137,"ENSG00000205643.10","CDPF1","chr22","-",46247105,46247221,46247109,46247221,46246672,46246795,137,"0,0","3,0","1,0","2,0",153,149,1,1,"0.0,NA","0.327,NA",-0.327]
[144,"ENSG00000100410.7","PHF5A","chr22","-",41468019,41468147,41468123,41468147,41467447,41467614,144,"26,33",12431084,"17,23",811890,253,149,0.712925506025,1,"0.012,0.018","0.012,0.015",1E-3]
[145,"ENSG00000100395.14","L3MBTL2","chr22","+",41217122,41219536,41217122,41217202,41220733,41220868,145,285264,"0,2",182195,"28,22",298,149,0,0,"1.0,0.985","0.765,0.816",0.202]
[146,"ENSG00000100372.14","SLC25A17","chr22","-",40797253,40797336,40797283,40797336,40794513,40794580,146,"1,2","1,8","0,2","2,0",179,149,0.905694527679,1,"0.454,0.172","0.0,1.0",-0.187]
[147,"ENSG00000100321.14","SYNGR1","chr22","+",39374315,39374660,39374315,39374553,39376051,39376197,147,"5,8","95,93","1,2","35,40",256,149,0.13470646538,0.332779697658166,"0.03,0.048","0.016,0.028",0.017]
[149,"ENSG00000100242.15","SUN2","chr22","-",38740266,38741050,38740888,38741050,38739721,38739943,149,247242,"0,0",405422,"0,2",298,149,1,1,"1.0,1.0","1.0,0.991",0.004]
[150,"ENSG00000100242.15","SUN2","chr22","-",38740266,38741050,38741006,38741050,38739721,38739943,150,255258,"0,0",455479,"1,0",298,149,1,1,"1.0,1.0","0.996,1.0",2E-3]
[151,"ENSG00000100242.15","SUN2","chr22","-",38740888,38741050,38741006,38741050,38739721,38739943,151,"18,31","0,0","77,86","1,0",267,149,1,1,"1.0,1.0","0.977,1.0",0.012]
[152,"ENSG00000100242.15","SUN2","chr22","-",38740888,38741050,38741006,38741050,38740266,38740432,152,"19,33",193140,"91,85",303301,267,149,1.08388873823E-3,0.00570451308619644,"0.052,0.116","0.144,0.136",-0.056]
[154,"ENSG00000100201.20","DDX17","chr22","-",38487872,38488115,38487878,38488115,38485934,38486440,154,368288,12891234,434523,17721779,155,149,0.744126773415,1,"0.215,0.183","0.191,0.22",-0.007]
[155,"ENSG00000100139.13","MICALL1","chr22","+",37927410,37927826,37927410,37927820,37931798,37931933,155,"82,64","5,5","51,83","2,2",155,149,0.0864812025751,0.233291067528316,"0.94,0.925","0.961,0.976",-0.036]
[158,"ENSG00000100150.17","DEPDC5","chr22","+",31784813,31785107,31784813,31784875,31792032,31792102,158,"13,16","127,59","23,11","48,60",298,149,0.0326084481553,0.105741631091342,"0.049,0.119","0.193,0.084",-0.055]
[159,"ENSG00000100150.17","DEPDC5","chr22","+",31797599,31797703,31797599,31797699,31798581,31798656,159,115128,"7,14","88,48","3,12",153,149,0.58645134835,1,"0.941,0.899","0.966,0.796",0.039]
[160,"ENSG00000100150.17","DEPDC5","chr22","+",31810520,31810665,31810520,31810641,31814991,31815212,160,"1,2",148146,"0,1",82105,173,149,1,1,"0.006,0.012","0.0,0.008",0.005]
[161,"ENSG00000100150.17","DEPDC5","chr22","+",31905983,31906094,31905983,31906066,31906204,31906975,161,"5,4",138132,"2,2","26,24",177,149,0.751838976699,1,"0.03,0.025","0.061,0.066",-0.036]
[162,"ENSG00000138942.15","RNF185","chr22","+",31196935,31197157,31196935,31196990,31201497,31201615,162,"10,16","47,56","21,21","70,88",298,149,0.785595744466,1,"0.096,0.125","0.13,0.107",-0.008]
[163,"ENSG00000138942.15","RNF185","chr22","+",31196935,31197158,31196935,31196990,31201497,31201615,163,"10,16","47,56","16,18","70,88",298,149,0.666044550113,1,"0.096,0.125","0.103,0.093",0.012]
[165,"ENSG00000185133.13","INPP5J","chr22","+",31124844,31126010,31124844,31124906,31126375,31126489,165,"2,6","2,1","9,0","0,0",298,149,1,1,"0.333,0.75","1.0,NA",-0.459]
[167,"ENSG00000185339.8","TCN2","chr22","+",30612872,30613042,30612872,30612961,30614348,30614501,167,"23,17","2,0","42,40","0,0",230,149,0.565925201478,0.980601905684418,"0.882,1.0","1.0,1.0",-0.059]
[168,"ENSG00000099999.14","RNF215","chr22","-",30379481,30379622,30379547,30379622,30377819,30378142,168,"27,20","0,1","36,23","0,0",215,149,1,1,"1.0,0.933","1.0,1.0",-0.033]
[169,"ENSG00000186575.17","NF2","chr22","+",29683019,29683079,29683019,29683064,29694751,29694811,169,"3,3","6,12","3,4","16,26",164,149,0.380910724075,0.74997027262058,"0.312,0.185","0.146,0.123",0.114]
[170,"ENSG00000100296.13","THOC5","chr22","-",29528273,29528466,29528425,29528466,29528077,29528177,170,"27,15",389407,"51,45",200202,298,149,{"v":7.22311099821e-13,"d":"7.22E-13"},{"v":1.68195298958318e-11,"d":"1.68E-11"},"0.034,0.018","0.113,0.1",-0.081]
[171,"ENSG00000100296.13","THOC5","chr22","-",29528936,29529239,29529161,29529239,29528425,29528466,171,"0,0",505562,"18,17",253228,298,149,{"v":1.24260735701e-07,"d":"1.24E-07"},{"v":1.48203657945826e-06,"d":"1.48E-06"},"0.0,0.0","0.034,0.036",-0.035]
[172,"ENSG00000100296.13","THOC5","chr22","-",29543414,29543542,29543428,29543542,29542858,29542956,172,"0,0",546542,"0,1",287277,163,149,1,1,"0.0,0.0","0.0,0.003",-2E-3]
[173,"ENSG00000100209.9","HSCB","chr22","+",28743881,28743978,28743881,28743923,28744614,28744704,173,121145,"0,0",80112,"4,2",204,149,0.0901826392075,0.240263702970352,"1.0,1.0","0.936,0.976",0.044]
[174,"ENSG00000100209.9","HSCB","chr22","+",28744614,28744709,28744614,28744704,28745255,28745543,174,"2,0","0,2","0,1","0,0",154,149,1,1,"1.0,0.0","NA,1.0",-0.5]
[175,"ENSG00000100209.9","HSCB","chr22","+",28744614,28744709,28744614,28744704,28745863,28746008,175,"25,29","71,63","15,29","45,38",154,149,0.442229541844,0.831689189267697,"0.254,0.308","0.244,0.425",-0.053]
[176,"ENSG00000100209.9","HSCB","chr22","+",28744614,28744709,28744614,28744704,28751240,28751288,176,"9,1","2,1","2,2","1,0",154,149,0.0856355066874,0.23147406556358,"0.813,0.492","0.659,1.0",-0.177]
[177,"ENSG00000183765.21","CHEK2","chr22","-",28741768,28741820,28741781,28741820,28711908,28712017,177,"1,0","0,0","4,0","0,1",162,149,1,1,"1.0,NA","1.0,0.0",0.5]
[178,"ENSG00000183765.21","CHEK2","chr22","-",28724564,28724923,28724885,28724923,28719394,28719485,178,"6,9","9,13","3,2","0,0",298,149,{"v":2.70434247873e-06,"d":"2.70E-06"},{"v":2.57008095284252e-05,"d":"2.57E-05"},"0.25,0.257","1.0,1.0",-0.746]
[179,"ENSG00000183765.21","CHEK2","chr22","-",28730419,28730548,28730455,28730548,28725242,28725367,179,"69,79","21,21","6,16","0,0",185,149,{"v":4.62855635519e-06,"d":"4.63E-06"},{"v":4.14950077242783e-05,"d":"4.15E-05"},"0.726,0.752","1.0,1.0",-0.261]
[180,"ENSG00000183765.21","CHEK2","chr22","-",28741768,28741820,28741781,28741820,28734402,28734727,180,111104,"14,3",122155,"4,2",162,149,0.00325248143556,0.0146647926587403,"0.879,0.97","0.966,0.986",-0.051]
[181,"ENSG00000100099.20","HPS4","chr22","-",26466225,26468623,26468550,26468623,26458444,26458577,181,"33,48","0,0",232146,"0,1",298,149,1,1,"1.0,1.0","1.0,0.986",0.007]
[182,"ENSG00000100099.20","HPS4","chr22","-",26465454,26466262,26466225,26466262,26463916,26464826,182,343417,"0,0",721747,"6,4",298,149,0.795016288324,1,"1.0,1.0","0.984,0.989",0.014]
[183,"ENSG00000100099.20","HPS4","chr22","-",26466225,26468623,26468550,26468623,26465454,26465551,183,247351,"0,0",475378,"1,0",298,149,1,1,"1.0,1.0","0.996,1.0",2E-3]
[185,"ENSG00000100031.18","GGT1","chr22","+",24628080,24628388,24628080,24628193,24628692,24628996,185,"16,23","0,0","26,14","3,0",298,149,0.185029467978,0.429923761664648,"1.0,1.0","0.812,1.0",0.094]
[186,"ENSG00000100028.11","SNRPD3","chr22","+",24567983,24568176,24567983,24568037,24571915,24572772,186,90358606,"4,6",67287200,"0,0",288,149,1,1,"0.999,0.999","1.0,1.0",-1E-3]
[187,"ENSG00000100028.11","SNRPD3","chr22","+",24567983,24568176,24567983,24568037,24572017,24572061,187,46194499,"143,95",35323845,92111,288,149,0.695702554467,1,"0.944,0.961","0.952,0.947",0.003]
[188,"ENSG00000099991.17","CABIN1","chr22","+",24098013,24098192,24098013,24098105,24113565,24113748,188,405360,"21,23",308316,"5,6",236,149,0.000123989178785,0.000826440883128271,"0.924,0.908","0.975,0.971",-0.057]
[193,"ENSG00000186716.20","BCR","chr22","+",23311696,23311918,23311696,23311836,23312886,23313021,193,"5,11",377369,"57,43",226248,231,149,0,0,"0.008,0.019","0.14,0.101",-0.107]
[194,"ENSG00000161179.13","YDJC","chr22","-",21629542,21629761,21629601,21629761,21629307,21629407,194,184194,"66,73",142167,"8,16",208,149,{"v":8.53372927878e-12,"d":"8.53E-12"},{"v":1.80011489374735E-10,"d":"1.80E-10"},"0.666,0.656","0.927,0.882",-0.244]
[199,"ENSG00000099949.19","LZTR1","chr22","+",20983026,20983122,20983026,20983089,20985840,20985897,199,"6,8",132133,"17,26",124108,182,149,{"v":3.78524963557E-5,"d":"3.79E-05"},0.000285566027906466,"0.036,0.047","0.101,0.165",-0.092]
[200,"ENSG00000099949.19","LZTR1","chr22","+",20983026,20983122,20983026,20983089,20988009,20988118,200,"1,3","0,0","6,12","2,0",182,149,0.681074122262,1,"1.0,1.0","0.711,1.0",0.145]
[201,"ENSG00000099949.19","LZTR1","chr22","+",20990385,20990969,20990385,20990525,20991627,20991829,201,"3,3",117132,"23,24",159145,298,149,{"v":1.48490835739E-7,"d":"1.48E-07"},{"v":1.73637435965235e-06,"d":"1.74E-06"},"0.013,0.011","0.067,0.076",-0.06]
[204,"ENSG00000226287.8","TMEM191A","chr22","+",20703967,20704056,20703967,20704040,20704187,20704228,204,"0,0","7,6","1,1","10,11",165,149,0.593646330718,1,"0.0,0.0","0.083,0.076",-0.08]
[205,"ENSG00000128191.15","DGCR8","chr22","+",20106591,20106698,20106591,20106685,20107270,20107398,205,450396,"0,4",311326,"0,6",162,149,0.904930648112,1,"1.0,0.989","1.0,0.98",0.004]
[207,"ENSG00000070010.18","UFD1","chr22","-",19475469,19475602,19475495,19475602,19475067,19475100,207,853777,"47,58",858954,"58,92",175,149,0.135986066842,0.335348870276359,"0.939,0.919","0.926,0.898",0.017]
[208,"ENSG00000070371.15","CLTCL1","chr22","-",19201328,19201493,19201390,19201493,19199733,19199841,208,"3,7","1,0","13,8","0,0",211,149,1,1,"0.679,1.0","1.0,1.0",-0.16]
[209,"ENSG00000100075.9","SLC25A1","chr22","-",19177726,19178041,19177941,19178041,19177119,19177204,209,310317,"2,2","76,54","1,0",298,149,1,1,"0.987,0.988","0.974,1.0",1E-3]
[210,"ENSG00000187325.4","TAF9B","chrX","-",78137748,78138098,78137961,78138098,78136914,78136990,210,166158,"1,0","36,50","0,0",298,149,1,1,"0.988,1.0","1.0,1.0",-0.006]
[211,"ENSG00000160299.16","PCNT","chr21","+",46431528,46432215,46431528,46431978,46435903,46436148,211,248323,178209,439355,"34,44",298,149,0,0,"0.411,0.436","0.866,0.801",-0.41]
[213,"ENSG00000182362.13","YBEY","chr21","+",46286869,46287123,46286869,46286988,46296161,46296230,213,385425,"6,2",154121,"0,0",284,149,0.512880989799,0.918065505533717,"0.971,0.991","1.0,1.0",-0.019]
[214,"ENSG00000160285.14","LSS","chr21","-",46222629,46222738,46222662,46222738,46221853,46221975,214,704770,"58,97",140156,"12,7",182,149,0.032776098287,0.106206405232393,"0.909,0.867","0.905,0.948",-0.038]
[215,"ENSG00000160285.14","LSS","chr21","-",46228433,46228824,46228731,46228824,46227551,46227690,215,675596,"0,1",194221,"0,0",298,149,1,1,"1.0,0.997","1.0,1.0",-2E-3]
[216,"ENSG00000183570.16","PCBP3","chr21","+",45913950,45914094,45913950,45914025,45917587,45917629,216,"0,6","9,11","2,2","0,1",218,149,0.000309236345859,1.87080193197887E-3,"0.0,0.272","1.0,0.578",-0.653]
[217,"ENSG00000160256.12","FAM207A","chr21","+",44943683,44943837,44943683,44943792,44960099,44960168,217,538619,325278,580529,284329,194,149,0.652975585806,1,"0.56,0.631","0.611,0.553",0.013]
[218,"ENSG00000160256.12","FAM207A","chr21","+",44943683,44943837,44943683,44943792,44973196,44973265,218,93117,"2,2",119104,"0,0",194,149,0.58913754026,1,"0.973,0.978","1.0,1.0",-0.024]
[219,"ENSG00000160226.15","CFAP410","chr21","-",44330462,44330916,44330822,44330916,44329890,44330326,219,"16,11","76,85","43,74","39,37",298,149,{"v":5.25135490648e-14,"d":"5.25E-14"},{"v":1.4053252757192e-12,"d":"1.41E-12"},"0.095,0.061","0.355,0.5",-0.349]
[220,"ENSG00000160226.15","CFAP410","chr21","-",44334060,44335804,44335757,44335804,44333032,44333262,220,"20,18",82130,"43,36","33,19",298,149,{"v":1.66533453694E-15,"d":"1.67E-15"},{"v":5.17793900242789e-14,"d":"5.18E-14"},"0.109,0.065","0.394,0.486",-0.353]
[221,"ENSG00000141959.16","PFKL","chr21","+",44313912,44316339,44313912,44314021,44316431,44316524,221,17491928,"0,0",10531069,"0,1",298,149,1,1,"1.0,1.0","1.0,0.998",1E-3]
[223,"ENSG00000160201.11","U2AF1","chr21","-",43100452,43104402,43104314,43104402,43095693,43095743,223,"27,11","0,0","3,3","4,9",298,149,{"v":1.09279252314e-12,"d":"1.09E-12"},{"v":2.51202178716669e-11,"d":"2.51E-11"},"1.0,1.0","0.273,0.143",0.792]
[224,"ENSG00000160185.14","UBASH3A","chr21","+",42434831,42435509,42434831,42434954,42437487,42437580,224,"7,2","82,75","22,14","67,71",298,149,{"v":1.3792647038E-5,"d":"1.38E-05"},1.124100733597E-4,"0.041,0.013","0.141,0.09",-0.088]
[225,"ENSG00000160185.14","UBASH3A","chr21","+",42434831,42435509,42434831,42434954,42437541,42437596,225,"7,2","3,4","20,15","1,1",298,149,0.000278700301356,1.69969265418812E-3,"0.538,0.2","0.909,0.882",-0.526]
[233,"ENSG00000157540.20","DYRK1A","chr21","+",37472683,37472880,37472683,37472829,37478207,37478300,233,566593,"0,0",789714,"1,2",200,149,1,1,"1.0,1.0","0.998,0.996",0.003]
[234,"ENSG00000159267.14","HLCS","chr21","-",36947332,36948287,36948165,36948287,36938831,36938994,234,"7,16","1,3","3,3","0,0",298,149,0.00275715968177,0.0127961707750136,"0.778,0.727","1.0,1.0",-0.248]
[236,"ENSG00000166979.12","EVA1C","chr21","+",32501414,32501495,32501414,32501486,32503925,32504015,236,"16,11","3,3","12,9","1,0",158,149,3.88605329545E-3,0.0172183531105647,"0.834,0.776","0.919,1.0",-0.155]
[237,"ENSG00000166979.12","EVA1C","chr21","+",32501414,32501538,32501414,32501486,32503925,32504015,237,"5,2","3,3","6,3","1,0",201,149,0.00048824166723,2.82392680433351E-3,"0.553,0.331","0.816,1.0",-0.466]
[238,"ENSG00000166979.12","EVA1C","chr21","+",32501414,32501538,32501414,32501495,32503925,32504015,238,"5,2","16,11","5,3","11,9",192,149,0.469604079863,0.862151753088906,"0.195,0.124","0.261,0.206",-0.074]
[239,"ENSG00000156256.14","USP16","chr21","+",29042471,29043599,29042471,29042528,29046666,29047321,239,768568,"0,0",925865,"1,5",298,149,1,1,"1.0,1.0","0.998,0.989",0.006]
[240,"ENSG00000156253.6","RWDD2B","chr21","-",29008239,29008621,29008394,29008621,29007760,29008123,240,226227,"68,62","30,26","43,57",298,149,0,0,"0.624,0.647","0.259,0.186",0.413]
[241,"ENSG00000156253.6","RWDD2B","chr21","-",29009594,29009692,29009626,29009692,29008394,29008621,241,"14,6","0,0","8,8","0,5",181,149,0.00242037258007,0.0114504697521517,"1.0,1.0","1.0,0.568",0.216]
[243,"ENSG00000237484.5","LINC01684","chr21","+",24438252,24438443,24438252,24438433,24441794,24441913,243,"64,71","24,32","53,59","14,20",159,149,0.22742509977,0.510141622878578,"0.714,0.675","0.78,0.734",-0.062]
[244,"ENSG00000012211.12","PRICKLE3","chrX","-",49183656,49183917,49183733,49183917,49179250,49179388,244,"3,2","0,4","21,15","1,1",226,149,0.115269396618,0.294565134552394,"1.0,0.248","0.933,0.908",-0.297]
[246,"ENSG00000203896.9","LIME1","chr20","+",63737820,63738060,63737820,63737902,63738182,63738499,246,"50,76","0,0",76140,"3,1",298,149,0.623799303769,1,"1.0,1.0","0.927,0.986",0.043]
[247,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63733739,63733586,63733712,63734644,63734824,247,"49,62","0,4","64,55","0,1",176,149,0.305703842214,0.641334230604175,"1.0,0.929","1.0,0.979",-0.025]
[248,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63733775,63733586,63733712,63734644,63734824,248,"53,48","0,4","64,48","0,1",212,149,0.164683466277,0.390406507317753,"1.0,0.894","1.0,0.971",-0.038]
[249,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63733775,63733586,63733739,63734644,63734824,249,"6,3","2,17","7,2","7,9",185,149,0.806498833346,1,"0.707,0.124","0.446,0.152",0.116]
[250,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63733739,63733586,63733712,63734704,63734824,250,132126,"14,14",163131,"13,10",176,149,0.282256714738,0.604402415834276,"0.889,0.884","0.914,0.917",-0.029]
[251,"ENSG00000197114.11","ZGPAT","chr20","+",63733586,63733775,63733586,63733739,63734704,63735185,251,"8,3","85,81","5,2","106,85",185,149,0.202687333188,0.463150027705289,"0.07,0.029","0.037,0.019",0.022]
[252,"ENSG00000026036.22","RTEL1-TNFRSF6B","chr20","+",63689749,63690210,63689749,63689865,63690293,63690441,252,304376,"9,3",179172,"2,1",298,149,0.087279595027,0.234855898774503,"0.944,0.984","0.978,0.989",-0.02]
[253,"ENSG00000026036.22","RTEL1-TNFRSF6B","chr20","+",63695327,63695650,63695327,63695480,63695777,63697191,253,256171,119111,146173,"51,48",298,149,1.8950992548E-3,0.00924192921502098,"0.518,0.435","0.589,0.643",-0.139]
[256,"ENSG00000101194.17","SLC17A9","chr20","+",62962623,62962754,62962623,62962734,62963272,62963369,256,246226,"17,14","49,74","8,8",169,149,0.0853400164753,0.230791326606655,"0.927,0.934","0.844,0.891",0.063]
[257,"ENSG00000101194.17","SLC17A9","chr20","+",62962623,62963369,62962623,62962734,62964227,62964315,257,211198,"0,0","60,66","1,0",298,149,1,1,"1.0,1.0","0.968,1.0",0.016]
[258,"ENSG00000101194.17","SLC17A9","chr20","+",62963583,62964022,62963583,62963680,62964227,62964315,258,"42,54",258249,"27,31","72,58",298,149,0.000142280120366,9.39048794415599E-4,"0.075,0.098","0.158,0.211",-0.098]
[259,"ENSG00000130703.16","OSBPL2","chr20","+",62242320,62242661,62242320,62242434,62256056,62256221,259,"4,10","3,2","3,2","0,0",298,149,{"v":3.18315277453e-05,"d":"3.18E-05"},2.44952486040012E-4,"0.4,0.714","1.0,1.0",-0.443]
[260,"ENSG00000130703.16","OSBPL2","chr20","+",62281057,62281879,62281057,62281165,62284045,62284169,260,166189,"0,0",153188,"9,15",298,149,{"v":9.0870163616e-09,"d":"9.09E-09"},{"v":1.28732321030192E-7,"d":"1.29E-07"},"1.0,1.0","0.895,0.862",0.121]
[261,"ENSG00000101181.17","MTG2","chr20","+",62199118,62199283,62199118,62199257,62200682,62202767,261,"6,26",211199,"39,35",284343,175,149,0.0652567268169,0.187608729849334,"0.024,0.1","0.105,0.08",-0.03]
[262,"ENSG00000101181.17","MTG2","chr20","+",62199118,62199283,62199118,62199257,62203083,62203568,262,"5,24","18,3","19,9","2,0",175,149,0.00273295615662,0.0127167570644108,"0.191,0.872","0.89,1.0",-0.414]
[263,"ENSG00000184402.14","SS18L1","chr20","+",62158671,62158942,62158671,62158748,62159876,62159961,263,"17,13",159144,"25,11",249292,298,149,0.183387398076,0.427149206370849,"0.051,0.043","0.048,0.018",0.014]
[264,"ENSG00000101182.14","PSMA7","chr20","-",62139695,62139905,62139780,62139905,62139074,62139197,264,136154,41214359,245199,40854012,234,149,0.000203748874716,0.00128785569576658,"0.021,0.022","0.037,0.031",-0.013]
[265,"ENSG00000130699.18","TAF4","chr20","-",62006509,62006758,62006545,62006758,62003159,62003274,265,"54,41","0,0","56,64","0,5",185,149,0.0906433974746,0.241371700502907,"1.0,1.0","1.0,0.912",0.044]
[266,"ENSG00000130699.18","TAF4","chr20","-",62006509,62006758,62006545,62006758,62003730,62003878,266,278285,"0,0",336348,"0,2",185,149,1,1,"1.0,1.0","1.0,0.993",0.004]
[269,"ENSG00000101158.13","NELFCD","chr20","+",58989857,58990232,58989857,58989988,58990909,58991075,269,"70,81",488537,"123,96",167187,298,149,0,0,"0.067,0.07","0.269,0.204",-0.168]
[270,"ENSG00000101158.13","NELFCD","chr20","+",58992997,58993544,58992997,58993112,58993623,58994239,270,494477,"0,0",240306,"3,5",298,149,0.107357220107,0.277765505991127,"1.0,1.0","0.976,0.968",0.028]
[271,"ENSG00000101158.13","NELFCD","chr20","+",58993623,58993764,58993623,58993675,58994109,58994239,271,870817,"65,45",285339,56109,238,149,{"v":1.47104550763E-13,"d":"1.47E-13"},{"v":3.76427167477357e-12,"d":"3.76E-12"},"0.893,0.919","0.761,0.661",0.195]
[272,"ENSG00000101158.13","NELFCD","chr20","+",58994109,58994239,58994109,58994191,58994641,58995133,272,10261042,"10,4",533517,"1,0",197,149,1,1,"0.987,0.995","0.998,1.0",-0.008]
[273,"ENSG00000087460.24","GNAS","chr20","+",58889159,58889353,58889159,58889332,58895611,58895684,273,908993,"54,83",568755,"60,63",170,149,0.110634745069,0.28460272296803,"0.936,0.913","0.892,0.913",0.022]
[274,"ENSG00000215440.11","NPEPL1","chr20","+",58691723,58691830,58691723,58691780,58693736,58693922,274,"14,3","14,16","12,13","38,35",199,149,0.520967708464,0.929644551479206,"0.428,0.123","0.191,0.218",0.071]
[275,"ENSG00000124222.22","STX16","chr20","+",58652072,58652138,58652072,58652087,58659622,58659634,275,"57,78","67,67",275227,446398,200,149,0.00285997694986,0.013227700785294,"0.388,0.464","0.315,0.298",0.12]
[276,"ENSG00000124222.22","STX16","chr20","+",58667489,58667608,58667489,58667597,58667986,58668127,276,"16,4",768752,"13,14",11201176,160,149,0.850277543449,1,"0.019,0.005","0.011,0.011",1E-3]
[277,"ENSG00000124222.22","STX16","chr20","+",58652072,58652138,58652072,58652087,58670511,58670603,277,"20,30","1,2","73,60","0,2",200,149,0.241629479909,0.535356910362963,"0.937,0.918","1.0,0.957",-0.051]
[278,"ENSG00000101138.11","CSTF1","chr20","+",56395520,56395759,56395520,56395721,56397206,56397484,278,"12,20",358383,"27,15",301327,187,149,0.0890659555065,0.237812939331437,"0.026,0.04","0.067,0.035",-0.018]
[279,"ENSG00000087586.17","AURKA","chr20","-",56392153,56392295,56392167,56392295,56390555,56390665,279,"19,20","26,16","13,15","9,10",163,149,0.235089552581,0.524055824008785,"0.4,0.533","0.569,0.578",-0.107]
[280,"ENSG00000124228.14","DDX27","chr20","+",49233567,49236231,49233567,49233709,49236332,49236510,280,559470,"0,0",393289,"1,12",298,149,0.00172033014122,0.00852086172156756,"1.0,1.0","0.995,0.923",0.041]
[281,"ENSG00000182518.13","FAM104B","chrX","-",55159125,55159228,55159128,55159228,55146180,55146311,281,"52,56",418326,"80,99",418401,152,149,0.01321849629,0.0497915206890126,"0.109,0.144","0.158,0.195",-0.05]
[282,"ENSG00000101040.19","ZMYND8","chr20","-",47238757,47239138,47238895,47239138,47236325,47236516,282,276227,936925,880780,596605,287,149,0,0,"0.133,0.113","0.434,0.401",-0.294]
[283,"ENSG00000062598.17","ELMO2","chr20","-",46393980,46394089,46394048,46394089,46393528,46393601,283,"12,24",220215,"21,23","75,94",217,149,{"v":1.38544748887E-5,"d":"1.39E-05"},1.1274314739231E-4,"0.036,0.071","0.161,0.144",-0.099]
[284,"ENSG00000080189.14","SLC35C2","chr20","-",46358386,46358763,46358690,46358763,46357622,46357702,284,182222,"0,0",340349,"0,4",298,149,1,1,"1.0,1.0","1.0,0.978",0.011]
[285,"ENSG00000101457.12","DNTTIP1","chr20","+",45801998,45802057,45801998,45802055,45803332,45803378,285,721735,"3,12",413413,"0,2",151,149,0.841675832411,1,"0.996,0.984","1.0,0.995",-0.008]
[286,"ENSG00000244274.7","DBNDD2","chr20","+",45408800,45409036,45408800,45408938,45409931,45410610,286,"8,10",178101,"20,28",184183,247,149,0.0117877800896,0.04503300362355,"0.026,0.056","0.062,0.084",-0.032]
[289,"ENSG00000101052.12","IFT52","chr20","+",43605001,43605216,43605001,43605073,43613849,43613976,289,"2,5","112,93","10,6",158117,292,149,0.165964376889,0.392405443202607,"0.009,0.027","0.031,0.026",-0.01]
[290,"ENSG00000196756.11","SNHG17","chr20","-",38435026,38435333,38435196,38435333,38434503,38434626,290,197260,"104,97",419525,146182,298,149,0.130990154404,0.325598909676116,"0.486,0.573","0.589,0.591",-0.06]
[291,"ENSG00000101407.12","TTI1","chr20","-",38011514,38013857,38013699,38013857,38006196,38006397,291,386361,"0,0",215280,"1,0",298,149,1,1,"1.0,1.0","0.991,1.0",0.004]
[292,"ENSG00000132792.18","CTNNBL1","chr20","+",37746467,37746609,37746467,37746607,37757560,37757656,292,"1,1","0,0","3,1","2,1",151,149,0.0168561494158,0.061512366151688,"1.0,1.0","0.597,0.497",0.453]
[293,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771473,36771424,36771473,36766768,36766841,293,"49,66","2,0",171189,"10,2",298,149,0.0547746379504,0.162153427372152,"0.925,1.0","0.895,0.979",0.025]
[294,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771473,36771424,36771473,36767968,36768042,294,599435,"73,76",407468,"15,15",298,149,{"v":3.19266835191e-12,"d":"3.19E-12"},{"v":7.09643101856359e-11,"d":"7.10E-11"},"0.804,0.741","0.931,0.94",-0.163]
[295,"ENSG00000101084.17","RAB5IF","chr20","+",36609600,36609758,36609600,36609730,36612009,36612557,295,"21,16",19831635,"24,25",11531142,177,149,6.27817885157E-3,0.0260038441028782,"0.009,0.008","0.017,0.018",-0.009]
[296,"ENSG00000080845.17","DLGAP4","chr20","+",36525850,36526077,36525850,36526006,36526812,36527231,296,"2,1",121119,"4,2","66,63",220,149,0.2080355748,0.473159981754418,"0.011,0.006","0.039,0.021",-0.021]
[297,"ENSG00000061656.9","SPAG4","chr20","+",35618449,35618720,35618449,35618475,35618922,35618998,297,"31,8","0,6","10,6","0,2",298,149,0.227838309759,0.510855468192438,"1.0,0.4","1.0,0.6",-0.1]
[301,"ENSG00000100983.10","GSS","chr20","-",34936762,34936840,34936764,34936840,34935575,34935642,301,599593,"0,2","43,46","0,0",151,149,1,1,"1.0,0.997","1.0,1.0",-2E-3]
[302,"ENSG00000100983.10","GSS","chr20","-",34942487,34943006,34942930,34943006,34936942,34937023,302,"53,65","5,0","11,8","61,80",298,149,0,0,"0.841,1.0","0.083,0.048",0.855]
[303,"ENSG00000100983.10","GSS","chr20","-",34942487,34943006,34942930,34943006,34941712,34941829,303,621659,"0,13","55,60","2,2",298,149,0.471218756233,0.863800543189247,"1.0,0.962","0.932,0.938",0.046]
[304,"ENSG00000100983.10","GSS","chr20","-",34951723,34951860,34951789,34951860,34945952,34946051,304,220200,"2,4","75,46","0,0",215,149,0.731565548721,1,"0.987,0.972","1.0,1.0",-0.02]
[307,"ENSG00000131061.13","ZNF341","chr20","+",33757147,33757343,33757147,33757322,33758715,33758806,307,"19,11","31,24","15,20","10,9",170,149,8.7996812997E-4,0.00470979957324241,"0.349,0.287","0.568,0.661",-0.297]
[308,"ENSG00000125967.16","NECAB3","chr20","-",33659496,33659732,33659652,33659732,33658721,33658834,308,"42,29","0,4","33,27","0,0",298,149,0.0538263819415,0.160139440521752,"1.0,0.784","1.0,1.0",-0.108]
[311,"ENSG00000022277.12","RTF2","chr20","+",56470599,56470941,56470599,56470751,56471613,56471669,311,"8,10","0,0","42,43","0,1",298,149,1,1,"1.0,1.0","1.0,0.956",0.022]
[312,"ENSG00000101294.17","HM13","chr20","+",31538178,31538359,31538178,31538261,31544946,31545035,312,"49,47",15341313,"137,99",732782,247,149,0,0,"0.019,0.021","0.101,0.071",-0.066]
[313,"ENSG00000101294.17","HM13","chr20","+",31538178,31538554,31538178,31538261,31544946,31545035,313,"78,58",15341313,171137,732782,298,149,0,0,"0.025,0.022","0.105,0.081",-0.07]
[314,"ENSG00000101294.17","HM13","chr20","+",31538178,31538554,31538178,31538359,31544946,31545035,314,"74,52","10,10",149173,"8,8",298,149,0.00163819641597,0.00818185563742119,"0.787,0.722","0.903,0.915",-0.155]
[315,"ENSG00000101310.16","SEC23B","chr20","+",18507939,18508297,18507939,18507972,18510821,18511056,315,"17,6",99110,"33,35",74121,298,149,{"v":8.14125949611e-06,"d":"8.14E-06"},{"v":6.88167588566321e-05,"d":"6.88E-05"},"0.079,0.027","0.182,0.126",-0.101]
[316,"ENSG00000125871.13","MGME1","chr20","+",17969800,17970370,17969800,17970130,17975683,17975903,316,615632,"15,4",411485,"3,0",298,149,0.00528030856547,0.0225432401647349,"0.953,0.988","0.986,1.0",-0.023]
[318,"ENSG00000101384.12","JAG1","chr20","-",10650246,10651694,10651580,10651694,10649521,10649635,318,"41,42","0,0","51,74","1,0",298,149,1,1,"1.0,1.0","0.962,1.0",0.019]
[319,"ENSG00000101311.15","FERMT1","chr20","-",6119403,6119572,6119420,6119572,6115810,6116044,319,"48,51","0,4","38,26","0,1",166,149,0.216211498497,0.488656155636707,"1.0,0.92","1.0,0.959",-0.02]
[320,"ENSG00000089195.14","TRMT6","chr20","-",5943826,5944031,5943947,5944031,5943558,5943683,320,"38,29",799767,"42,80",404478,270,149,{"v":2.38178143874e-10,"d":"2.38E-10"},{"v":4.31367082794022e-09,"d":"4.31E-09"},"0.026,0.02","0.054,0.085",-0.047]
[321,"ENSG00000125779.22","PANK2","chr20","+",3907925,3908278,3907925,3908135,3910576,3910830,321,494481,228239,389364,"37,49",292,149,0,0,"0.525,0.507","0.843,0.791",-0.301]
[322,"ENSG00000101220.17","C20orf27","chr20","-",3760006,3760186,3760081,3760186,3758535,3758678,322,"28,30",555632,"6,16",281374,224,149,0.112791943601,0.289046147989413,"0.032,0.031","0.014,0.028",0.01]
[324,"ENSG00000101266.18","CSNK2A1","chr20","-",486375,487575,487426,487575,481146,484076,324,13971293,"0,0",16241602,"0,1",298,149,1,1,"1.0,1.0","1.0,0.999",0]
[325,"ENSG00000101266.18","CSNK2A1","chr20","-",487426,488778,488677,488778,486375,486462,325,23272234,"0,0",24162453,"1,0",298,149,1,1,"1.0,1.0","0.999,1.0",0]
[326,"ENSG00000101266.18","CSNK2A1","chr20","-",499254,499934,499832,499934,497720,497780,326,23582245,"0,3",20531975,"117,73",298,149,0,0,"1.0,0.997","0.898,0.931",0.084]
[329,"ENSG00000099326.8","MZF1","chr19","-",58570343,58571429,58570993,58571429,58569515,58569586,329,198184,"1,1",274228,"1,0",298,149,1,1,"0.99,0.989","0.993,1.0",-0.007]
[330,"ENSG00000099326.8","MZF1","chr19","-",58573054,58573575,58573372,58573575,58570993,58571429,330,"60,54","15,4",81125,"3,11",298,149,0.0514231855724,0.154355644639475,"0.667,0.871","0.931,0.85",-0.122]
[331,"ENSG00000283515.1","AC020915.5","chr19","+",58246300,58246427,58246300,58246390,58246710,58246794,331,413379,"1,0",158188,"1,1",186,149,1,1,"0.997,1.0","0.992,0.993",0.006]
[333,"ENSG00000178935.5","ZNF552","chr19","-",57814532,57814913,57814710,57814913,57803840,57804064,333,"18,9","0,0","35,23","1,0",298,149,1,1,"1.0,1.0","0.946,1.0",0.027]
[334,"ENSG00000178935.5","ZNF552","chr19","-",57814532,57814913,57814710,57814913,57813293,57813420,334,"31,21","82,41","53,29","46,63",298,149,0.0655840721958,0.188348491372775,"0.159,0.204","0.366,0.187",-0.095]
[335,"ENSG00000251369.8","ZNF550","chr19","-",57543650,57544583,57544236,57544583,57541839,57543243,335,"85,99","6,3","18,30","0,0",298,149,1.83234212243E-3,0.00897754225358923,"0.876,0.943","1.0,1.0",-0.091]
[337,"ENSG00000105146.12","AURKC","chr19","+",57232541,57232685,57232541,57232680,57233459,57233608,337,"2,0","0,7","2,0","1,1",154,149,0.674327584439,1,"1.0,0.0","0.659,0.0",0.17]
[340,"ENSG00000166770.10","ZNF667-AS1","chr19","+",56478182,56478381,56478182,56478276,56497300,56497449,340,"89,75","4,0",170166,"0,0",254,149,0.391956091699,0.763918133848351,"0.929,1.0","1.0,1.0",-0.035]
[341,"ENSG00000131848.9","ZSCAN5A","chr19","-",56314619,56314839,56314680,56314839,56313282,56313384,341,"13,19","63,60","18,19","23,38",210,149,6.37162178495E-3,0.0263031109602809,"0.128,0.183","0.357,0.262",-0.154]
[342,"ENSG00000063244.12","U2AF2","chr19","+",55669082,55669181,55669082,55669169,55669443,55669692,342,568565,24132402,496707,23832719,161,149,0.9436860422,1,"0.179,0.179","0.162,0.194",1E-3]
[343,"ENSG00000108107.14","RPL28","chr19","+",55386569,55386693,55386569,55386674,55387929,55388048,343,5598256295,"21,19",5229053981,"29,25",168,149,1,1,"1.0,1.0","0.999,0.999",1E-3]
[344,"ENSG00000131037.14","EPS8L1","chr19","+",55082091,55082349,55082091,55082180,55082453,55082602,344,"69,82","0,0","42,56","0,4",298,149,0.107544383483,0.2781159801707,"1.0,1.0","1.0,0.875",0.062]
[345,"ENSG00000160439.15","RDH13","chr19","-",55047104,55047488,55047386,55047488,55044342,55045309,345,"20,18",223230,"9,18",160170,298,149,0.875527546177,1,"0.043,0.038","0.027,0.05",2E-3]
[346,"ENSG00000088053.11","GP6","chr19","-",55015678,55015733,55015682,55015733,55013704,55015165,346,"0,0","16,12","3,0","1,0",153,149,1,1,"0.0,0.0","0.745,NA",-0.745]
[347,"ENSG00000022556.15","NLRP2","chr19","+",54969998,54970295,54969998,54970153,54974499,54974544,347,719701,"0,0",546523,"0,2",291,149,1,1,"1.0,1.0","1.0,0.993",0.004]
[348,"ENSG00000022556.15","NLRP2","chr19","+",54990021,54990192,54990021,54990096,54990501,54990672,348,934770,"0,0",671663,"0,2",245,149,1,1,"1.0,1.0","1.0,0.995",2E-3]
[349,"ENSG00000022556.15","NLRP2","chr19","+",54990021,54990393,54990021,54990096,54990501,54990672,349,430399,"0,0",296235,"0,2",298,149,1,1,"1.0,1.0","1.0,0.983",0.008]
[350,"ENSG00000022556.15","NLRP2","chr19","+",54990021,54990393,54990021,54990192,54990501,54990672,350,116119,607483,"15,14",386436,298,149,0,0,"0.087,0.11","0.019,0.016",0.081]
[357,"ENSG00000170906.15","NDUFA3","chr19","+",54102868,54102898,54102868,54102888,54103113,54103188,357,"8,9",825791,"15,6",7611021,159,149,0.75011375737,1,"0.009,0.011","0.018,0.005",-2E-3]
[358,"ENSG00000170906.15","NDUFA3","chr19","+",54102868,54102898,54102868,54102888,54105933,54106011,358,"0,1","10,1","1,0","5,7",159,149,1,1,"0.0,0.484","0.158,0.0",0.163]
[359,"ENSG00000170949.17","ZNF160","chr19","-",53091412,53091720,53091636,53091720,53086261,53086321,359,"54,53","42,43","47,49","75,72",298,149,0.00260249290333,0.0121623017610878,"0.391,0.381","0.239,0.254",0.14]
[360,"ENSG00000167555.13","ZNF528","chr19","+",52397867,52397904,52397867,52397900,52398366,52398619,360,"10,10","3,1","30,29","4,5",153,149,0.835918237739,1,"0.764,0.907","0.88,0.85",-0.029]
[361,"ENSG00000221923.8","ZNF880","chr19","+",52374298,52374427,52374298,52374394,52374483,52374717,361,"19,32","10,2","32,47","8,7",182,149,0.874064647213,1,"0.609,0.929","0.766,0.846",-0.037]
[362,"ENSG00000167554.14","ZNF610","chr19","+",52347706,52347944,52347706,52347831,52349153,52349235,362,"14,19","0,1","44,53","6,5",262,149,1,1,"1.0,0.915","0.807,0.858",0.125]
[363,"ENSG00000196214.10","ZNF766","chr19","+",52274461,52274669,52274461,52274582,52282110,52282237,363,"2,5","2,0","8,19","0,0",236,149,0.343778842334,0.696120038912175,"0.387,1.0","1.0,1.0",-0.306]
[364,"ENSG00000176024.17","ZNF613","chr19","+",51929731,51929896,51929731,51929824,51940208,51940335,364,"27,38","0,0","29,28","1,0",221,149,1,1,"1.0,1.0","0.951,1.0",0.024]
[365,"ENSG00000142512.14","SIGLEC10","chr19","-",51415897,51416357,51416309,51416357,51415567,51415615,365,205228,"41,29",163172,"70,70",298,149,{"v":1.30769239359E-6,"d":"1.31E-06"},{"v":1.30988405681948E-5,"d":"1.31E-05"},"0.714,0.797","0.538,0.551",0.211]
[377,"ENSG00000062822.13","POLD1","chr19","+",50409518,50409666,50409518,50409594,50413425,50413521,377,12671137,148172,858897,"80,86",221,149,0.0143373631711,0.0535188594707473,"0.852,0.817","0.879,0.876",-0.043]
[378,"ENSG00000062822.13","POLD1","chr19","+",50415437,50415590,50415437,50415559,50415723,50415826,378,11061001,"8,20",688761,"10,8",180,149,0.758292976975,1,"0.991,0.976","0.983,0.987",-1E-3]
[379,"ENSG00000062822.13","POLD1","chr19","+",50415437,50415602,50415437,50415559,50415723,50415826,379,120128,"8,20",113130,"10,8",192,149,0.196652215796,0.451854877730322,"0.921,0.832","0.898,0.927",-0.036]
[380,"ENSG00000062822.13","POLD1","chr19","+",50415437,50415602,50415437,50415590,50415723,50415826,380,"1,7",987880,"8,14",583645,161,149,0.131342564335,0.326173431928885,"0.001,0.007","0.013,0.02",-0.013]
[381,"ENSG00000062822.13","POLD1","chr19","+",50415723,50416528,50415723,50415826,50416609,50416723,381,545587,"10,6",562611,"2,0",298,149,0.00621298787992,0.0258466061918713,"0.965,0.98","0.993,1.0",-0.024]
[382,"ENSG00000131408.13","NR1H2","chr19","+",50376472,50376826,50376472,50376576,50377586,50377648,382,330301,"0,0",349413,"0,4",298,149,1,1,"1.0,1.0","1.0,0.981",0.01]
[383,"ENSG00000131408.13","NR1H2","chr19","+",50378148,50378439,50378148,50378312,50378521,50378796,383,367372,"4,1",317370,"0,6",276,149,0.848661751755,1,"0.98,0.995","1.0,0.971",2E-3]
[384,"ENSG00000105053.10","VRK3","chr19","-",50020461,50020647,50020584,50020647,50016023,50016163,384,"1,3",416472,"7,1",234270,272,149,1,1,"0.001,0.003","0.016,0.002",-0.007]
[385,"ENSG00000105053.10","VRK3","chr19","-",50025266,50025372,50025345,50025372,50020584,50020647,385,"18,30",200232,"26,24",126136,228,149,0.0244552802856,0.083786594048562,"0.056,0.078","0.119,0.103",-0.044]
[387,"ENSG00000104951.15","IL4I1","chr19","-",49929325,49929496,49929416,49929496,49927693,49927815,387,192211,"47,25",199194,"12,15",240,149,4.34508093468E-4,0.0025432198419634,"0.717,0.84","0.911,0.889",-0.122]
[388,"ENSG00000104960.15","PTOV1","chr19","+",49850734,49851096,49850734,49850955,49854405,49854543,388,"16,17","2,3","12,32","1,0",290,149,0.00323798882597,0.0146116962205475,"0.804,0.744","0.86,1.0",-0.156]
[389,"ENSG00000126457.21","PRMT1","chr19","+",49680139,49680253,49680139,49680238,49680486,49680588,389,"104,90","79,84",72103,"47,66",164,149,0.160092660657,0.382388286711369,"0.545,0.493","0.582,0.586",-0.065]
[390,"ENSG00000126453.9","BCL2L12","chr19","+",49669023,49669164,49669023,49669115,49670215,49670488,390,"6,15",667882,"35,28",516520,198,149,{"v":3.16002868317e-09,"d":"3.16E-09"},{"v":4.78811106669617e-08,"d":"4.79E-08"},"0.007,0.013","0.049,0.039",-0.034]
[391,"ENSG00000104870.12","FCGRT","chr19","+",49513881,49514486,49513881,49514133,49521694,49521813,391,"10,15","0,2","52,58","1,0",298,149,0.896360831197,1,"1.0,0.789","0.963,1.0",-0.087]
[392,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49489922,49489849,49489912,49490231,49490297,392,5918061662,341293,8008591932,12931606,159,149,{"v":2.78854800362E-8,"d":"2.79E-08"},{"v":3.66738379253593e-07,"d":"3.67E-07"},"0.994,0.995","0.983,0.982",0.012]
[393,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490090,49489849,49489912,49490231,49490297,393,250316,341293,317319,12931606,298,149,0,0,"0.268,0.35","0.109,0.09",0.209]
[394,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490090,49489849,49489922,49490231,49490297,394,214272,5914261613,290275,8004591880,298,149,1,1,"0.002,0.002","0.002,0.001",1E-3]
[395,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49489922,49489849,49489912,49490474,49490576,395,"41,49","7,3","54,97","13,21",159,149,0.0388834490596,0.122599104625784,"0.846,0.939","0.796,0.812",0.088]
[396,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490297,49489849,49489912,49490474,49490576,396,7275473467,"7,3",101369113733,"13,21",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[397,"ENSG00000142541.16","RPL13A","chr19","+",49489849,49490297,49489849,49489922,49490474,49490576,397,7271873423,"3,0",101342113689,"14,45",298,149,1,1,"1.0,1.0","1.0,0.999",0]
[398,"ENSG00000142541.16","RPL13A","chr19","+",49490231,49490576,49490231,49490297,49490778,49490864,398,7036866811,"1,0",99935101239,"14,22",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[399,"ENSG00000142541.16","RPL13A","chr19","+",49490474,49490600,49490474,49490576,49490778,49490864,399,"91,61",7000666483,"118,98",99480100698,173,149,1,1,"0.001,0.001","0.001,0.001",0]
[400,"ENSG00000142541.16","RPL13A","chr19","+",49490778,49491099,49490778,49490864,49491424,49491547,400,8023879969,"0,1",8596790492,"1,3",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[401,"ENSG00000104872.10","PIH1D1","chr19","-",49449339,49449654,49449474,49449654,49448000,49448062,401,122110,940916,"67,92",250249,284,149,{"v":1.53624490906E-9,"d":"1.54E-09"},{"v":2.47409022929153e-08,"d":"2.47E-08"},"0.064,0.059","0.123,0.162",-0.081]
[402,"ENSG00000104872.10","PIH1D1","chr19","-",49451367,49451578,49451484,49451578,49450781,49450848,402,"28,35",548565,"32,46",157147,266,149,{"v":4.43978187548e-13,"d":"4.44E-13"},{"v":1.04743801351784e-11,"d":"1.05E-11"},"0.028,0.034","0.102,0.149",-0.095]
[404,"ENSG00000104894.11","CD37","chr19","+",49335713,49335786,49335713,49335782,49335885,49336029,404,"10,8","2,2","7,10","0,0",153,149,0.00544005897267,0.0231138050663443,"0.83,0.796","1.0,1.0",-0.187]
[405,"ENSG00000104894.11","CD37","chr19","+",49335713,49335786,49335713,49335782,49336908,49337033,405,723700,"56,34",839861,"60,67",153,149,0.316563554428,0.656138326810906,"0.926,0.952","0.932,0.926",0.01]
[406,"ENSG00000130529.15","TRPM4","chr19","+",49182577,49182922,49182577,49182867,49183077,49183212,406,"1,1","0,6","0,5","1,1",204,149,0.249199611853,0.547567284377976,"1.0,0.109","0.0,0.785",0.162]
[407,"ENSG00000104805.15","NUCB1","chr19","+",48900785,48901121,48900785,48900931,48904346,48904454,407,"28,20",16981542,"18,16",9991169,298,149,1,1,"0.008,0.006","0.009,0.007",-1E-3]
[408,"ENSG00000104805.15","NUCB1","chr19","+",48913473,48913564,48913473,48913532,48918666,48918744,408,480435,"3,0",278290,"3,2",181,149,1,1,"0.992,1.0","0.987,0.992",0.006]
[411,"ENSG00000105443.14","CYTH2","chr19","+",48474837,48474953,48474837,48474949,48478068,48478145,411,"0,2",214215,"2,1","31,47",153,149,0.445041149352,0.83433001561685,"0.0,0.009","0.059,0.02",-0.035]
[412,"ENSG00000142227.10","EMP3","chr19","+",48327520,48327623,48327520,48327561,48329351,48329492,412,73197203,"25,16",42174553,"7,9",211,149,1,1,"0.995,0.997","0.998,0.997",-2E-3]
[413,"ENSG00000142227.10","EMP3","chr19","+",48327520,48327664,48327520,48327561,48329351,48329492,413,20892008,"25,16",12231381,"7,9",252,149,0.0847690101469,0.229846644702204,"0.98,0.987","0.99,0.989",-0.006]
[414,"ENSG00000142227.10","EMP3","chr19","+",48327520,48327664,48327520,48327623,48329351,48329492,414,"30,28",52605223,"46,51",30403223,190,149,0.287347269398,0.611391381129017,"0.004,0.004","0.012,0.012",-0.008]
[415,"ENSG00000105483.17","CARD8","chr19","-",48232452,48234543,48234402,48234543,48231659,48231810,415,454382,"55,33",534511,"13,5",298,149,{"v":2.04836148043e-13,"d":"2.05E-13"},{"v":5.00824381965135e-12,"d":"5.01E-12"},"0.805,0.853","0.954,0.981",-0.139]
[416,"ENSG00000105486.13","LIG1","chr19","-",48120166,48121322,48121169,48121322,48119136,48119190,416,"77,49",518572,"36,50",270328,298,149,0.249434882939,0.547860447255565,"0.069,0.041","0.062,0.071",-0.011]
[417,"ENSG00000178980.14","SELENOW","chr19","+",47780863,47781000,47780863,47780917,47781107,47781182,417,"8,7",308259,"8,11",326404,232,149,0.964042493196,1,"0.016,0.017","0.016,0.017",0]
[418,"ENSG00000105373.18","NOP53","chr19","+",47752511,47752559,47752511,47752544,47755473,47755523,418,119138,"5,4",178189,"9,17",164,149,0.0427801001142,0.132860368657206,"0.956,0.969","0.947,0.91",0.034]
[419,"ENSG00000105373.18","NOP53","chr19","+",47754708,47754891,47754708,47754757,47756527,47756604,419,16531766,"0,1",26342649,"0,0",283,149,1,1,"1.0,0.999","1.0,1.0",0]
[420,"ENSG00000105402.7","NAPA","chr19","-",47492014,47493493,47493415,47493493,47490787,47490856,420,11571265,"0,0",12501064,"0,1",298,149,1,1,"1.0,1.0","1.0,0.998",1E-3]
[421,"ENSG00000105402.7","NAPA","chr19","-",47503392,47503502,47503422,47503502,47500632,47500749,421,"6,13",12641295,"12,12",9981060,179,149,1,1,"0.004,0.008","0.01,0.009",-0.003]
[423,"ENSG00000118162.13","KPTN","chr19","-",47483125,47483215,47483160,47483215,47480957,47481033,423,"13,20",192172,"11,12",149112,184,149,0.909449495204,1,"0.052,0.086","0.056,0.08",1E-3]
[424,"ENSG00000118162.13","KPTN","chr19","-",47483125,47483215,47483160,47483215,47481578,47481634,424,"18,18","2,0","11,12","0,0",184,149,0.62947107984,1,"0.879,1.0","1.0,1.0",-0.06]
[426,"ENSG00000090372.14","STRN4","chr19","-",46721985,46722340,46722241,46722340,46720535,46720771,426,11481237,"8,7",585663,"25,15",298,149,{"v":4.2015783408e-08,"d":"4.20E-08"},{"v":5.34043706624774e-07,"d":"5.34E-07"},"0.986,0.989","0.921,0.957",0.048]
[427,"ENSG00000105287.12","PRKD2","chr19","-",46678365,46678663,46678395,46678663,46675032,46675118,427,"5,0",328275,"0,2",222261,179,149,1,1,"0.013,0.0","0.0,0.006",0.003]
[428,"ENSG00000125755.18","SYMPK","chr19","-",45828969,45829205,45829054,45829205,45827836,45827918,428,9891010,"6,11",845686,"4,9",234,149,0.980148561667,1,"0.991,0.983","0.993,0.98",1E-3]
[429,"ENSG00000125755.18","SYMPK","chr19","-",45854174,45854507,45854390,45854507,45852481,45852535,429,666719,"0,0",695668,"1,0",298,149,1,1,"1.0,1.0","0.997,1.0",2E-3]
[430,"ENSG00000104936.17","DMPK","chr19","-",45777326,45777590,45777341,45777590,45774948,45775034,430,"10,9","1,12","34,22","2,2",164,149,0.0120709255667,0.0459515276880957,"0.901,0.405","0.939,0.909",-0.271]
[433,"ENSG00000125744.11","RTN2","chr19","-",45494117,45494420,45494165,45494420,45489345,45489553,433,"2,0","7,0","0,1","6,1",197,149,1,1,"0.178,NA","0.0,0.431",-0.038]
[434,"ENSG00000104866.10","PPP1R37","chr19","+",45140505,45140661,45140505,45140606,45141321,45141386,434,"4,10",135137,"11,12",137112,204,149,0.0886984062015,0.237367525849685,"0.021,0.051","0.055,0.073",-0.028]
[435,"ENSG00000104853.15","CLPTM1","chr19","+",44954590,44955085,44954590,44954701,44961962,44962075,435,"20,1","0,8","23,33","2,4",298,149,0.434491629604,0.822643602829959,"1.0,0.059","0.852,0.805",-0.299]
[436,"ENSG00000069399.14","BCL3","chr19","+",44758245,44758473,44758245,44758413,44758723,44758841,436,"0,0","17,17","3,0","28,20",209,149,0.610690272895,1,"0.0,0.0","0.071,0.0",-0.035]
[437,"ENSG00000073008.14","PVR","chr19","+",44658741,44658900,44658741,44658765,44661291,44661323,437,"99,97","8,30","24,15","0,1",284,149,1.85958389217E-4,0.0011851542364908,"0.867,0.629","1.0,0.887",-0.196]
[439,"ENSG00000159917.16","ZNF235","chr19","-",44298807,44298903,44298819,44298903,44234754,44234869,439,"8,8","1,1","6,6","9,10",161,149,{"v":2.5012869624e-05,"d":"2.50E-05"},0.000195843123300576,"0.881,0.881","0.382,0.357",0.512]
[440,"ENSG00000159917.16","ZNF235","chr19","-",44298807,44298903,44298819,44298903,44236109,44236729,440,"1,7","12,7","7,9","7,3",161,149,0.0390260417819,0.122904612848267,"0.072,0.481","0.481,0.735",-0.332]
[441,"ENSG00000159917.16","ZNF235","chr19","-",44298807,44298903,44298819,44298903,44274751,44274921,441,"1,3","0,2","1,4","0,0",161,149,0.548612649648,0.963745082448266,"1.0,0.581","1.0,1.0",-0.21]
[442,"ENSG00000159882.12","ZNF230","chr19","+",44008789,44008991,44008789,44008916,44009083,44009170,442,"0,3","33,50","0,3","51,47",224,149,0.900509438869,1,"0.0,0.038","0.0,0.041",-2E-3]
[443,"ENSG00000167619.11","TMEM145","chr19","+",42314791,42314893,42314791,42314851,42314992,42315077,443,"8,11","3,0","27,46","2,0",191,149,0.270720111126,0.585033360800905,"0.675,1.0","0.913,1.0",-0.119]
[444,"ENSG00000160570.13","DEDD2","chr19","-",42215132,42215252,42215147,42215252,42209699,42209840,444,144182,"8,10",317346,"20,15",164,149,0.900198242565,1,"0.942,0.943","0.935,0.954",-2E-3]
[445,"ENSG00000105372.7","RPS19","chr19","+",41860254,41860445,41860254,41860289,41860774,41860845,445,96119,66367077,"76,70",1097610120,298,149,1,1,"0.007,0.008","0.003,0.003",0.004]
[446,"ENSG00000105341.18","DMAC2","chr19","-",41436391,41436472,41436428,41436472,41433536,41433673,446,511398,"8,17",235230,"4,5",186,149,0.251467027557,0.550671638258641,"0.981,0.949","0.979,0.974",-0.011]
[447,"ENSG00000105341.18","DMAC2","chr19","-",41438217,41438414,41438234,41438414,41433536,41433673,447,95136,"0,0",630727,"21,13",166,149,0.00355648631926,0.0158101982738012,"1.0,1.0","0.964,0.98",0.028]
[448,"ENSG00000071553.16","ATP6AP1","chrX","+",154429047,154429403,154429047,154429174,154431519,154431600,448,"30,15","2,1","19,20","0,0",298,149,0.250472775762,0.549691171286739,"0.882,0.882","1.0,1.0",-0.118]
[449,"ENSG00000071553.16","ATP6AP1","chrX","+",154429047,154431657,154429047,154429174,154431829,154431904,449,"40,35",562692,"24,24",992868,298,149,{"v":6.55065727757e-05,"d":"6.55E-05"},0.000464242233149526,"0.034,0.025","0.012,0.014",0.017]
[450,"ENSG00000071553.16","ATP6AP1","chrX","+",154432930,154432971,154432930,154432965,154433634,154433720,450,760766,"0,0",900982,"0,1",155,149,1,1,"1.0,1.0","1.0,0.999",0]
[453,"ENSG00000100124.14","ANKRD54","chr22","-",37832957,37833206,37833158,37833206,37832636,37832744,453,210206,"3,6",169153,"32,33",298,149,{"v":1.87183601952e-13,"d":"1.87E-13"},{"v":4.61862658210921E-12,"d":"4.62E-12"},"0.972,0.945","0.725,0.699",0.246]
[454,"ENSG00000269858.5","EGLN2","chr19","+",40807137,40807551,40807137,40807274,40807808,40808432,454,9871109,"8,2",10421047,"2,2",298,149,0.922414653444,1,"0.984,0.996","0.996,0.996",-0.006]
[456,"ENSG00000167578.17","RAB4B","chr19","+",40780018,40780499,40780018,40780099,40783777,40783840,456,"55,65","1,0","18,10","0,0",298,149,1,1,"0.965,1.0","1.0,1.0",-0.018]
[458,"ENSG00000123815.11","COQ8B","chr19","-",40703368,40703622,40703540,40703622,40702599,40702693,458,"6,6",117190,"14,27",170184,298,149,0.000528255645396,0.00301324190518036,"0.025,0.016","0.04,0.068",-0.034]
[459,"ENSG00000090006.17","LTBP4","chr19","+",40611858,40611984,40611858,40611976,40612072,40612192,459,"63,54","3,8","58,48","2,0",157,149,0.00234282624262,0.0111129297698879,"0.952,0.865","0.965,1.0",-0.074]
[460,"ENSG00000090006.17","LTBP4","chr19","+",40616888,40617042,40616888,40617020,40619346,40619493,460,"1,1","65,72","1,0","13,10",171,149,1,1,"0.013,0.012","0.063,0.0",-0.019]
[461,"ENSG00000105223.19","PLD3","chr19","+",40348699,40348768,40348699,40348724,40365661,40365930,461,"0,4","1,0","9,1","2,1",193,149,0.169979564731,0.400841770577838,"0.0,1.0","0.776,0.436",-0.106]
[462,"ENSG00000105223.19","PLD3","chr19","+",40365552,40365930,40365552,40365585,40366418,40366510,462,398431,"26,31",260271,"12,6",298,149,0.00721466089889,0.0293997431629767,"0.884,0.874","0.915,0.958",-0.057]
[463,"ENSG00000160392.13","C19orf47","chr19","-",40341785,40341890,40341838,40341890,40336319,40336407,463,"52,37","66,69","10,14","70,55",202,149,{"v":4.23598880861e-06,"d":"4.24E-06"},{"v":3.81664720293353e-05,"d":"3.82E-05"},"0.368,0.283","0.095,0.158",0.199]
[464,"ENSG00000187187.13","ZNF546","chr19","+",39998247,39998410,39998247,39998332,40006095,40006182,464,"21,2","2,1","0,2","0,0",227,149,1,1,"0.873,0.568","NA,1.0",-0.28]
[465,"ENSG00000105202.8","FBL","chr19","-",39840682,39840787,39840721,39840787,39840413,39840509,465,318301,"65,61",309409,"73,92",188,149,0.448281300168,0.838131773932454,"0.795,0.796","0.77,0.779",0.021]
[466,"ENSG00000105202.8","FBL","chr19","-",39840616,39840787,39840619,39840787,39840413,39840515,466,225229,"30,25",280261,"41,50",152,149,0.102067608093,0.266904066082764,"0.88,0.9","0.87,0.837",0.037]
[467,"ENSG00000105202.8","FBL","chr19","-",39840616,39840787,39840655,39840787,39840413,39840515,467,231233,"8,12",281266,"7,10",188,149,0.35029555153,0.705709668234369,"0.958,0.939","0.97,0.955",-0.014]
[468,"ENSG00000105202.8","FBL","chr19","-",39840619,39840787,39840655,39840787,39840413,39840515,468,"36,29","8,12","42,55","7,10",185,149,0.149118916582,0.360614819421896,"0.784,0.661","0.829,0.816",-0.1]
[470,"ENSG00000130669.17","PAK4","chr19","+",39168229,39168312,39168229,39168302,39168624,39168840,470,"4,8","0,1","0,5","0,0",159,149,1,1,"1.0,0.882","NA,1.0",-0.059]
[471,"ENSG00000130669.17","PAK4","chr19","+",39168229,39168312,39168229,39168302,39169531,39169757,471,"79,68",114143,"34,49",74105,159,149,0.286392452811,0.610584622937126,"0.394,0.308","0.301,0.304",0.048]
[472,"ENSG00000130669.17","PAK4","chr19","+",39172917,39173376,39172917,39173106,39173575,39174010,472,218225,"1,1",391420,"1,0",298,149,1,1,"0.991,0.991","0.995,1.0",-0.007]
[473,"ENSG00000068903.19","SIRT2","chr19","-",38880820,38880897,38880849,38880897,38880684,38880736,473,245289,"0,0",407366,"2,0",178,149,1,1,"1.0,1.0","0.994,1.0",0.003]
[476,"ENSG00000167645.16","YIF1B","chr19","-",38309223,38309643,38309404,38309643,38308978,38309057,476,884940,"0,6",831822,"4,12",298,149,0.0998505424638,0.262028320162887,"1.0,0.987","0.99,0.972",0.013]
[479,"ENSG00000188283.11","ZNF383","chr19","+",37235548,37235758,37235548,37235675,37235978,37236074,479,"7,5","45,47","24,37","43,88",232,149,{"v":4.41143916766e-05,"d":"4.41E-05"},0.000326847538331172,"0.091,0.064","0.264,0.213",-0.161]
[481,"ENSG00000105258.8","POLR2I","chr19","-",36114150,36114251,36114176,36114251,36114014,36114066,481,"14,25",11331002,"13,20",642807,175,149,0.450670534081,0.841361679952225,"0.01,0.021","0.017,0.021",-0.004]
[482,"ENSG00000239382.10","ALKBH6","chr19","-",36013000,36013089,36013020,36013089,36010893,36011045,482,"0,4","3,2","13,8","25,30",169,149,0.908406284818,1,"0.0,0.638","0.314,0.19",0.067]
[483,"ENSG00000239382.10","ALKBH6","chr19","-",36013000,36013089,36013020,36013089,36010893,36011065,483,"4,4","0,0","13,8","0,4",169,149,0.0205994697618,0.0726111060607616,"1.0,1.0","1.0,0.638",0.181]
[484,"ENSG00000239382.10","ALKBH6","chr19","-",36013020,36013422,36013343,36013422,36011403,36011464,484,145126,"0,0",110136,"2,0",298,149,1,1,"1.0,1.0","0.965,1.0",0.018]
[485,"ENSG00000239382.10","ALKBH6","chr19","-",36013309,36013422,36013327,36013422,36013020,36013089,485,"1,0","0,0","2,0","0,2",167,149,1,1,"1.0,NA","1.0,0.0",0.5]
[486,"ENSG00000239382.10","ALKBH6","chr19","-",36013309,36013422,36013343,36013422,36013020,36013089,486,"1,0",103101,"3,0",116133,183,149,1,1,"0.008,0.0","0.021,0.0",-0.007]
[487,"ENSG00000239382.10","ALKBH6","chr19","-",36013327,36013422,36013343,36013422,36013020,36013089,487,"0,0",103101,"1,2",116133,165,149,1,1,"0.0,0.0","0.008,0.013",-0.01]
[493,"ENSG00000100412.15","ACO2","chr22","+",41515766,41515992,41515766,41515917,41517526,41517631,493,"6,15",925886,"42,30",231230,224,149,0,0,"0.004,0.011","0.108,0.08",-0.086]
[494,"ENSG00000064601.18","CTSA","chr20","+",45892724,45892887,45892724,45892880,45893219,45893311,494,"7,13",752651,"6,9",474597,156,149,0.908693735586,1,"0.009,0.019","0.012,0.014",1E-3]
[495,"ENSG00000064601.18","CTSA","chr20","+",45892724,45892887,45892724,45892880,45893987,45894072,495,"5,6","2,2","5,10","19,21",156,149,0.000706212329855,0.00387010684047325,"0.705,0.741","0.201,0.313",0.466]
[496,"ENSG00000089327.14","FXYD5","chr19","+",35154752,35154869,35154752,35154809,35155532,35155611,496,"2,6","4,7","0,9","23,17",209,149,0.0771612959732,0.212955675238503,"0.263,0.379","0.0,0.274",0.184]
[497,"ENSG00000089327.14","FXYD5","chr19","+",35157420,35157617,35157420,35157501,35158343,35158400,497,"47,39",47734762,109119,49234907,265,149,0.0498932863982,0.150603808942714,"0.006,0.005","0.012,0.013",-0.007]
[498,"ENSG00000089327.14","FXYD5","chr19","+",35166250,35166428,35166250,35166325,35169565,35169879,498,"22,31",42553754,"53,43",31563147,252,149,1,1,"0.003,0.005","0.01,0.008",-0.005]
[499,"ENSG00000089327.14","FXYD5","chr19","+",35166141,35166325,35166141,35166171,35169565,35169880,499,43123800,"76,59",33133322,10791107,298,149,0,0,"0.966,0.97","0.606,0.6",0.365]
[502,"ENSG00000089335.20","ZNF302","chr19","+",34677638,34678103,34677638,34677856,34678736,34678813,502,"30,49","58,66",118107,"78,70",298,149,{"v":1.3638354296e-05,"d":"1.36E-05"},0.000111321256082221,"0.205,0.271","0.431,0.433",-0.194]
[503,"ENSG00000089335.20","ZNF302","chr19","+",34677646,34677856,34677646,34677796,34678736,34678813,503,"68,71","6,16","103,85","7,6",209,149,0.0339885709841,0.109344810600163,"0.89,0.76","0.913,0.91",-0.087]
[505,"ENSG00000180182.10","MED14","chrX","-",40681847,40681943,40681851,40681943,40680757,40680910,505,"0,2",487474,"0,0",357301,153,149,1,1,"0.0,0.004","0.0,0.0",2E-3]
[506,"ENSG00000105171.9","POP4","chr19","+",29608656,29608744,29608656,29608709,29610408,29610632,506,"1,2",341305,"4,1",352372,184,149,1,1,"0.002,0.005","0.009,0.002",-2E-3]
[507,"ENSG00000105171.9","POP4","chr19","+",29608656,29608744,29608656,29608709,29611861,29611939,507,"1,0","15,6","1,3","32,29",184,149,0.129999427559,0.323584877760231,"0.051,0.0","0.025,0.077",-0.026]
[509,"ENSG00000196268.11","ZNF493","chr19","+",21397132,21397422,21397132,21397267,21405128,21405255,509,"8,8","22,25","17,22","39,24",298,149,0.085874610953,0.232003783182414,"0.154,0.138","0.179,0.314",-0.1]
[510,"ENSG00000181896.11","ZNF101","chr19","+",19677863,19677990,19677863,19677986,19678725,19678786,510,"97,95","50,41",97108,"13,30",153,149,0.000594472046778,3.34834046033388E-3,"0.654,0.693","0.879,0.778",-0.155]
[511,"ENSG00000105717.13","PBX4","chr19","-",19570098,19570299,19570108,19570299,19569448,19569584,511,"2,0","4,7","0,0","3,2",159,149,0.731107563457,1,"0.319,0.0","0.0,0.0",0.16]
[512,"ENSG00000105717.13","PBX4","chr19","-",19570585,19570833,19570686,19570833,19570108,19570299,512,"3,2","2,14","1,2","0,0",250,149,{"v":2.25884464466e-08,"d":"2.26E-08"},{"v":3.00750627317478E-7,"d":"3.01E-07"},"0.472,0.078","1.0,1.0",-0.725]
[513,"ENSG00000186010.18","NDUFA13","chr19","+",19527280,19527372,19527280,19527352,19527700,19527770,513,"1,0",20892050,"2,2",21542581,169,149,1,1,"0.0,0.0","0.001,0.001",-1E-3]
[514,"ENSG00000213999.15","MEF2B","chr19","-",19149216,19149429,19149225,19149429,19147697,19147832,514,"0,1","18,30","0,0","18,17",158,149,1,1,"0.0,0.03","0.0,0.0",0.015]
[515,"ENSG00000064607.16","SUGP2","chr19","-",18993637,18993740,18993647,18993740,18991339,18991553,515,"30,27","0,4","69,72","0,0",159,149,0.126051363455,0.315950738128818,"1.0,0.863","1.0,1.0",-0.069]
[517,"ENSG00000130475.14","FCHO1","chr19","+",17754316,17754466,17754316,17754361,17754591,17754685,517,"6,13","15,19","12,8","6,2",254,149,0.00295063637321,0.0135537771575547,"0.19,0.286","0.54,0.701",-0.383]
[518,"ENSG00000130475.14","FCHO1","chr19","+",17754591,17754758,17754591,17754621,17755117,17755191,518,"20,23","0,3","16,17","0,0",286,149,0.201669731706,0.461216618557216,"1.0,0.8","1.0,1.0",-0.1]
[520,"ENSG00000160117.14","ANKLE1","chr19","+",17283224,17283962,17283224,17283884,17284088,17284266,520,363388,"24,36",172156,"2,3",227,149,{"v":3.04216549007e-06,"d":"3.04E-06"},{"v":2.85083766046803e-05,"d":"2.85E-05"},"0.908,0.876","0.983,0.972",-0.086]
[521,"ENSG00000160117.14","ANKLE1","chr19","+",17282655,17283002,17282655,17282761,17285430,17285590,521,"19,19","0,0","96,77","1,0",298,149,1,1,"1.0,1.0","0.98,1.0",0.01]
[522,"ENSG00000160117.14","ANKLE1","chr19","+",17283224,17283962,17283224,17283884,17285430,17285590,522,208217,"0,10","87,80","19,15",227,149,{"v":2.69613220638E-10,"d":"2.70E-10"},{"v":4.81810469704917e-09,"d":"4.82E-09"},"1.0,0.934","0.75,0.778",0.203]
[523,"ENSG00000105393.15","BABAM1","chr19","+",17267442,17267527,17267442,17267516,17268793,17269091,523,370319,"10,6",255295,"3,11",160,149,0.807253484257,1,"0.972,0.98","0.988,0.962",1E-3]
[524,"ENSG00000130307.11","USHBP1","chr19","-",17264560,17264724,17264670,17264724,17264245,17264347,524,"0,0","2,0","3,2","8,1",259,149,1,1,"0.0,NA","0.177,0.535",-0.356]
[527,"ENSG00000214046.8","SMIM7","chr19","-",16647095,16647261,16647119,16647261,16631376,16631664,527,"88,59","0,0",105115,"4,1",173,149,0.573077897396,0.989472881408564,"1.0,1.0","0.958,0.99",0.026]
[529,"ENSG00000268790.5","AC008764.4","chr19","-",16659954,16660000,16659958,16660000,16659394,16659447,529,"3,0",273306,"0,2",410480,153,149,1,1,"0.011,0.0","0.0,0.004",0.003]
[530,"ENSG00000127527.13","EPS15L1","chr19","-",16402314,16402485,16402320,16402485,16395343,16395467,530,"3,1",182179,"6,5",137146,155,149,0.0195541174448,0.0694726537223112,"0.016,0.005","0.04,0.032",-0.026]
[531,"ENSG00000127527.13","EPS15L1","chr19","-",16440861,16440909,16440884,16440909,16434364,16434490,531,"20,24","0,0","35,30","2,0",172,149,0.332855334872,0.678964295137083,"1.0,1.0","0.938,1.0",0.031]
[532,"ENSG00000127527.13","EPS15L1","chr19","-",16440861,16440909,16440884,16440909,16436936,16436999,532,"21,25","0,0","45,36","0,1",172,149,1,1,"1.0,1.0","1.0,0.969",0.016]
[533,"ENSG00000127527.13","EPS15L1","chr19","-",16440861,16440909,16440884,16440909,16437769,16437865,533,189203,"4,1",181175,"11,7",172,149,1.54341650711E-3,7.7807285770803E-3,"0.976,0.994","0.934,0.956",0.04]
[536,"ENSG00000011243.17","AKAP8L","chr19","-",15398629,15399410,15399301,15399410,15397713,15397855,536,184223,498445,314275,496548,298,149,0.0343164958452,0.110202048448555,"0.156,0.2","0.24,0.201",-0.043]
[537,"ENSG00000011243.17","AKAP8L","chr19","-",15403474,15403715,15403657,15403715,15401149,15401603,537,885887,"0,0",10471052,"1,1",298,149,1,1,"1.0,1.0","0.998,0.998",2E-3]
[538,"ENSG00000011243.17","AKAP8L","chr19","-",15403652,15403715,15403657,15403715,15403474,15403555,538,"39,23",107121,"28,38","41,40",154,149,{"v":2.76310707868e-05,"d":"2.76E-05"},0.000215090491696378,"0.261,0.155","0.398,0.479",-0.23]
[539,"ENSG00000099797.14","TECR","chr19","+",14564785,14564992,14564785,14564858,14565065,14565123,539,23532070,"17,22",16661647,"65,56",283,149,{"v":6.87117029941e-13,"d":"6.87E-13"},{"v":1.60695761045766E-11,"d":"1.61E-11"},"0.986,0.98","0.931,0.939",0.048]
[540,"ENSG00000099797.14","TECR","chr19","+",14564785,14564992,14564785,14564858,14565201,14565290,540,"52,52","0,1","151,97","29,31",283,149,{"v":6.72793154521e-10,"d":"6.73E-10"},{"v":1.14162598680393e-08,"d":"1.14E-08"},"1.0,0.965","0.733,0.622",0.305]
[541,"ENSG00000099797.14","TECR","chr19","+",14564785,14565123,14564785,14564858,14565201,14565290,541,18941711,"0,1",16101491,"29,31",298,149,{"v":2.23912000052e-11,"d":"2.24E-11"},{"v":4.52790469278085e-10,"d":"4.53E-10"},"1.0,0.999","0.965,0.96",0.037]
[542,"ENSG00000099797.14","TECR","chr19","+",14564785,14565123,14564785,14564992,14565201,14565290,542,18701698,"0,0",15211457,"4,5",280,149,1,1,"1.0,1.0","0.995,0.994",0.006]
[545,"ENSG00000104915.14","STX10","chr19","-",13144763,13144870,13144767,13144870,13144576,13144671,545,684624,"7,17",691690,"12,26",153,149,0.131815853364,0.327046805924795,"0.99,0.973","0.982,0.963",0.009]
[546,"ENSG00000104907.12","TRMT1","chr19","-",13105266,13105606,13105486,13105606,13104906,13105081,546,11871154,"0,0",710810,"2,4",298,149,1,1,"1.0,1.0","0.994,0.99",0.008]
[547,"ENSG00000104907.12","TRMT1","chr19","-",13112895,13113011,13112908,13113011,13110157,13110306,547,"69,74","3,3","39,47","9,9",162,149,0.000276510429819,0.00168825153461566,"0.955,0.958","0.799,0.828",0.143]
[548,"ENSG00000104907.12","TRMT1","chr19","-",13112895,13113011,13112908,13113011,13112704,13112817,548,684703,"80,73",342417,"41,24",162,149,0.149202715519,0.360614819421896,"0.887,0.899","0.885,0.941",-0.02]
[549,"ENSG00000104907.12","TRMT1","chr19","-",13115996,13116431,13116105,13116431,13115625,13115768,549,656610,"0,0",331304,"2,0",258,149,1,1,"1.0,1.0","0.99,1.0",0.005]
[550,"ENSG00000104907.12","TRMT1","chr19","-",13115996,13116431,13116145,13116431,13115625,13115768,550,664617,"0,0",357314,"21,22",298,149,0,0,"1.0,1.0","0.895,0.877",0.114]
[551,"ENSG00000104907.12","TRMT1","chr19","-",13115996,13116431,13116186,13116431,13115625,13115768,551,813806,"0,0",474430,"1,0",298,149,1,1,"1.0,1.0","0.996,1.0",2E-3]
[552,"ENSG00000104907.12","TRMT1","chr19","-",13116105,13116431,13116145,13116431,13115625,13115768,552,"8,9","0,0","29,10","21,22",189,149,{"v":1.57137099999e-08,"d":"1.57E-08"},{"v":2.1617403091934e-07,"d":"2.16E-07"},"1.0,1.0","0.521,0.264",0.607]
[553,"ENSG00000104907.12","TRMT1","chr19","-",13116105,13116431,13116186,13116431,13115625,13115768,553,161212,"0,0",161145,"1,0",230,149,1,1,"1.0,1.0","0.991,1.0",0.004]
[554,"ENSG00000104907.12","TRMT1","chr19","-",13116145,13116340,13116186,13116340,13115625,13115768,554,153203,"0,0",153157,"1,0",190,149,1,1,"1.0,1.0","0.992,1.0",0.004]
[555,"ENSG00000104907.12","TRMT1","chr19","-",13116145,13116340,13116186,13116340,13115996,13116052,555,732763,"8,13",411413,"10,9",190,149,0.173604164323,0.407958409739369,"0.986,0.979","0.97,0.973",0.011]
[556,"ENSG00000104907.12","TRMT1","chr19","-",13116145,13116431,13116171,13116431,13115996,13116052,556,694725,"0,1",370384,"0,0",175,149,1,1,"1.0,0.998","1.0,1.0",-1E-3]
[557,"ENSG00000104907.12","TRMT1","chr19","-",13116171,13116431,13116186,13116431,13115996,13116052,557,"38,39","8,13","41,29","10,9",164,149,0.901967643226,1,"0.812,0.732","0.788,0.745",0.006]
[558,"ENSG00000179115.10","FARSA","chr19","-",12928534,12928663,12928572,12928663,12928341,12928457,558,24452673,"14,14",11571218,"7,8",187,149,1,1,"0.993,0.993","0.992,0.992",1E-3]
[559,"ENSG00000105607.12","GCDH","chr19","+",12891486,12891660,12891486,12891522,12891830,12891974,559,"43,60",224251,"14,19","29,54",287,149,0.0302419691147,0.0994933038947836,"0.091,0.11","0.2,0.154",-0.076]
[560,"ENSG00000095059.15","DHPS","chr19","-",12679456,12679719,12679622,12679719,12677290,12677396,560,1140997,"2,0",818882,"0,0",298,149,1,1,"0.997,1.0","1.0,1.0",-2E-3]
[561,"ENSG00000095059.15","DHPS","chr19","-",12680149,12680325,12680160,12680325,12679800,12679922,561,"47,72",700821,"53,58",618727,160,149,0.740669019789,1,"0.059,0.076","0.074,0.069",-0.004]
[562,"ENSG00000095059.15","DHPS","chr19","-",12680149,12680325,12680195,12680325,12679800,12679922,562,316352,"38,36",294337,"55,40",195,149,0.107048726139,0.277100624591761,"0.864,0.882","0.803,0.866",0.038]
[563,"ENSG00000095059.15","DHPS","chr19","-",12680160,12680325,12680195,12680325,12679800,12679922,563,9691101,"38,36",8591006,"55,40",184,149,0.0562894456543,0.166180531380065,"0.954,0.961","0.927,0.953",0.018]
[564,"ENSG00000095059.15","DHPS","chr19","-",12680149,12680325,12680160,12680325,12679800,12680030,564,"6,6","2,0","15,19","7,6",160,149,0.0297461007863,0.09816213259479,"0.736,1.0","0.666,0.747",0.161]
[565,"ENSG00000173875.13","ZNF791","chr19","+",12612225,12612365,12612225,12612316,12623699,12623826,565,"4,10","1,5","6,4","0,0",198,149,{"v":3.10449635618E-5,"d":"3.10E-05"},0.000239585163556559,"0.751,0.601","1.0,1.0",-0.324]
[566,"ENSG00000213297.8","ZNF625-ZNF20","chr19","-",12147675,12147802,12147679,12147802,12147394,12147455,566,"25,32","0,0","36,31","0,1",153,149,1,1,"1.0,1.0","1.0,0.968",0.016]
[569,"ENSG00000130159.13","ECSIT","chr19","-",11507701,11508048,11507990,11508048,11507456,11507562,569,339270,"3,8",255267,"18,12",298,149,0.000549379064267,0.00311348640112845,"0.983,0.944","0.876,0.918",0.067]
[570,"ENSG00000187266.13","EPOR","chr19","-",11382846,11383232,11383096,11383232,11381929,11382105,570,"11,6","26,25","10,10","33,47",298,149,0.513847293164,0.918877855694533,"0.175,0.107","0.132,0.096",0.027]
[571,"ENSG00000197256.10","KANK2","chr19","-",11195555,11195820,11195621,11195820,11194474,11194590,571,172195,"44,32","78,71","18,28",215,149,0.140997576257,0.344739073948365,"0.73,0.809","0.75,0.637",0.076]
[572,"ENSG00000142453.11","CARM1","chr19","+",10908549,10908668,10908549,10908633,10909102,10909207,572,"8,10","1,0","0,2","0,0",184,149,1,1,"0.866,1.0","NA,1.0",-0.067]
[573,"ENSG00000142453.11","CARM1","chr19","+",10908549,10908747,10908549,10908633,10909102,10909207,573,"23,28","1,0","8,15","0,0",263,149,1,1,"0.929,1.0","1.0,1.0",-0.035]
[574,"ENSG00000142453.11","CARM1","chr19","+",10908549,10908747,10908549,10908668,10909102,10909207,574,"15,19","0,1","8,13","0,0",228,149,1,1,"1.0,0.925","1.0,1.0",-0.037]
[575,"ENSG00000099203.6","TMED1","chr19","-",10835255,10835353,10835290,10835353,10834933,10835117,575,208308,"0,0",294344,"1,0",184,149,1,1,"1.0,1.0","0.996,1.0",2E-3]
[576,"ENSG00000213339.8","QTRT1","chr19","+",10701949,10702254,10701949,10702018,10707301,10707380,576,450349,"1,4",265292,"18,9",298,149,{"v":3.10623496036E-7,"d":"3.11E-07"},{"v":3.47368770307202e-06,"d":"3.47E-06"},"0.996,0.978","0.88,0.942",0.076]
[577,"ENSG00000213339.8","QTRT1","chr19","+",10712160,10712628,10712160,10712299,10712757,10712867,577,552525,"4,11",416450,"0,0",298,149,8.40510891904E-3,0.0336040891138519,"0.986,0.96","1.0,1.0",-0.027]
[579,"ENSG00000129353.14","SLC44A2","chr19","+",10634755,10635073,10634755,10634887,10635162,10635255,579,252232,"0,0","58,74","1,0",298,149,1,1,"1.0,1.0","0.967,1.0",0.016]
[580,"ENSG00000129353.14","SLC44A2","chr19","+",10634755,10635073,10634755,10634887,10636661,10636756,580,"7,19","0,0","14,29","1,3",298,149,0.00818648657917,0.0328375177549257,"1.0,1.0","0.875,0.829",0.148]
[581,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547075,10546838,10547071,10547188,10547253,581,"9,3","33,18","1,4","5,8",153,149,0.762081613304,1,"0.21,0.14","0.163,0.327",-0.07]
[582,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547082,10546838,10547071,10547188,10547253,582,"15,13","33,18","3,10","5,8",160,149,0.292219603976,0.618589967988959,"0.297,0.402","0.358,0.538",-0.098]
[583,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547115,10546838,10547071,10547188,10547253,583,117128,"33,18","15,42","5,8",193,149,0.874385137455,1,"0.732,0.846","0.698,0.802",0.039]
[584,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547082,10546838,10547075,10547188,10547253,584,"11,12","5,2","2,6","0,0",156,149,0.000163795872942,1.06151566331929E-3,"0.678,0.851","1.0,1.0",-0.236]
[585,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547115,10546838,10547075,10547188,10547253,585,113127,"5,2","14,38","0,0",189,149,0.0681519632838,0.19365526175571,"0.947,0.98","1.0,1.0",-0.036]
[586,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547115,10546838,10547082,10547188,10547253,586,111121,"9,6","13,34","1,2",182,149,0.549879715616,0.964713111210916,"0.91,0.943","0.914,0.933",0.003]
[587,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547115,10546838,10547071,10548903,10549034,587,"21,33","0,0","7,25","1,0",193,149,1,1,"1.0,1.0","0.844,1.0",0.078]
[588,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547253,10546838,10547071,10548903,10549034,588,267271,"0,0",92130,"1,0",298,149,1,1,"1.0,1.0","0.979,1.0",0.01]
[589,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547253,10546838,10547115,10548903,10549034,589,252244,"1,0",93118,"0,0",287,149,1,1,"0.992,1.0","1.0,1.0",-0.004]
[590,"ENSG00000130734.9","ATG4D","chr19","+",10546838,10547115,10546838,10547071,10551896,10551975,590,"20,33","0,0","8,25","2,0",193,149,0.810054690744,1,"1.0,1.0","0.755,1.0",0.123]
[591,"ENSG00000105401.8","CDC37","chr19","-",10393258,10393441,10393279,10393441,10393085,10393157,591,12901582,"19,16",11001191,"14,16",170,149,0.850072296565,1,"0.983,0.989","0.986,0.985",0]
[592,"ENSG00000076662.9","ICAM3","chr19","-",10335065,10335353,10335140,10335353,10334527,10334782,592,193203,"5,1",370345,"1,7",224,149,0.770487548703,1,"0.963,0.993","0.996,0.97",-0.005]
[593,"ENSG00000076662.9","ICAM3","chr19","-",10335065,10335976,10335670,10335976,10334527,10334782,593,144117,"6,22",291256,"20,28",298,149,0.706388398864,1,"0.923,0.727","0.879,0.821",-0.025]
[594,"ENSG00000267673.6","FDX2","chr19","-",10315385,10315759,10315704,10315759,10310852,10310940,594,358276,"0,2",281321,"0,2",298,149,1,1,"1.0,0.986","1.0,0.988",-1E-3]
[596,"ENSG00000130816.15","DNMT1","chr19","-",10135438,10135852,10135735,10135852,10134216,10134307,596,"13,21",11461103,"39,73",281308,298,149,0,0,"0.006,0.009","0.065,0.106",-0.078]
[597,"ENSG00000130812.10","ANGPTL6","chr19","-",10093692,10093880,10093812,10093880,10093348,10093619,597,"66,92","2,2","44,60","0,0",269,149,0.410537272206,0.792350192750654,"0.948,0.962","1.0,1.0",-0.045]
[599,"ENSG00000127445.13","PIN1","chr19","+",9849089,9849311,9849089,9849201,9849532,9849682,599,835739,"40,33",658745,"21,31",259,149,0.269043909635,0.582369090513748,"0.923,0.928","0.947,0.933",-0.014]
[600,"ENSG00000198258.10","UBL5","chr19","+",9827891,9828064,9827891,9827984,9828326,9828393,600,225234,16421771,258323,14671797,229,149,0.020670783518,0.0727671103032212,"0.082,0.079","0.103,0.105",-0.023]
[601,"ENSG00000198258.10","UBL5","chr19","+",9828326,9828393,9828326,9828389,9828591,9828675,601,39384216,"46,97",32774140,"64,74",153,149,0.660225365602,1,"0.988,0.977","0.98,0.982",1E-3]
[602,"ENSG00000171469.10","ZNF561","chr19","-",9617044,9617171,9617048,9617171,9614020,9614103,602,133114,"0,0","54,45","2,0",153,149,0.745750430287,1,"1.0,1.0","0.963,1.0",0.018]
[603,"ENSG00000171469.10","ZNF561","chr19","-",9620915,9621231,9621161,9621231,9619431,9619582,603,"24,52","51,30","55,29","48,55",298,149,0.743380278546,1,"0.19,0.464","0.364,0.209",0.041]
[604,"ENSG00000188321.13","ZNF559","chr19","+",9337795,9337865,9337795,9337858,9338493,9338582,604,"2,0","38,36","4,0","0,0",156,149,1,1,"0.048,0.0","1.0,NA",-0.976]
[605,"ENSG00000188321.13","ZNF559","chr19","+",9337795,9338017,9337795,9337858,9338493,9338582,605,"51,27","38,36","22,21","0,0",298,149,{"v":7.49400541622e-14,"d":"7.49E-14"},{"v":1.975992898718e-12,"d":"1.98E-12"},"0.402,0.273","1.0,1.0",-0.662]
[608,"ENSG00000142347.17","MYO1F","chr19","-",8555636,8555796,8555658,8555796,8554653,8554743,608,"6,6",675655,"0,4",541440,171,149,1,1,"0.008,0.008","0.0,0.008",0.004]
[609,"ENSG00000099783.11","HNRNPM","chr19","+",8463496,8463504,8463496,8463500,8463592,8463686,609,42363886,"1,2",49285051,"2,3",153,149,1,1,"1.0,0.999","1.0,0.999",0]
[610,"ENSG00000099783.11","HNRNPM","chr19","+",8465323,8465515,8465323,8465362,8466234,8466388,610,81697784,"15,16",91219298,"5,4",298,149,1,1,"0.996,0.996","0.999,0.999",-0.003]
[619,"ENSG00000076944.15","STXBP2","chr19","+",7647161,7647511,7647161,7647247,7647724,7647873,619,976916,"7,20",456566,"47,80",298,149,0,0,"0.986,0.958","0.829,0.78",0.167]
[621,"ENSG00000032444.16","PNPLA6","chr19","+",7542760,7543084,7542760,7542928,7549906,7550112,621,125162,"0,0",181160,"0,1",298,149,1,1,"1.0,1.0","1.0,0.988",0.006]
[622,"ENSG00000205744.9","DENND1C","chr19","-",6471264,6471496,6471405,6471496,6470294,6470366,622,"95,93","1,0",133146,"11,11",290,149,{"v":3.27313996462e-06,"d":"3.27E-06"},{"v":3.05133793235545e-05,"d":"3.05E-05"},"0.98,1.0","0.861,0.872",0.123]
[623,"ENSG00000088247.17","KHSRP","chr19","-",6415533,6415734,6415608,6415734,6415379,6415457,623,20102268,209310,21932538,235246,224,149,0.17394181699,0.408573377113192,"0.865,0.83","0.861,0.873",-0.02]
[624,"ENSG00000125656.9","CLPP","chr19","+",6361868,6362542,6361868,6361940,6364451,6364639,624,11101229,"0,0",689756,"4,1",298,149,1,1,"1.0,1.0","0.989,0.997",0.007]
[625,"ENSG00000125656.9","CLPP","chr19","+",6362445,6362542,6362445,6362525,6364451,6364639,625,12071339,"1,3",699780,"3,0",166,149,1,1,"0.999,0.998","0.995,1.0",1E-3]
[626,"ENSG00000130254.11","SAFB2","chr19","-",5616127,5616335,5616131,5616335,5613464,5613527,626,"59,29",607525,"86,79",478524,153,149,{"v":6.0551541925e-06,"d":"6.06E-06"},{"v":5.29351997008714E-5,"d":"5.29E-05"},"0.086,0.051","0.149,0.128",-0.07]
[627,"ENSG00000167664.8","TMIGD2","chr19","-",4294566,4294680,4294578,4294680,4292231,4292885,627,217244,241259,266327,290293,161,149,0.470922946637,0.863653095792848,"0.455,0.466","0.459,0.508",-0.023]
[628,"ENSG00000077463.14","SIRT6","chr19","-",4175679,4175937,4175841,4175937,4174703,4174946,628,"14,25","0,0","72,56","3,0",298,149,0.70090749381,1,"1.0,1.0","0.923,1.0",0.038]
[629,"ENSG00000077463.14","SIRT6","chr19","-",4175679,4175937,4175841,4175937,4175027,4175151,629,113121,"0,0",183155,"2,7",298,149,0.00505618651629,0.021723024976936,"1.0,1.0","0.979,0.917",0.052]
[630,"ENSG00000126934.13","MAP2K2","chr19","-",4094452,4095449,4095387,4095449,4090323,4090708,630,13211235,"0,0",1009983,"0,1",298,149,1,1,"1.0,1.0","1.0,0.998",1E-3]
[631,"ENSG00000240225.10","ZNF542P","chr19","+",56368138,56368460,56368138,56368220,56368865,56368936,631,84100,"8,6",97141,"8,1",298,149,0.117886373635,0.299532736789166,"0.84,0.893","0.858,0.986",-0.055]
[632,"ENSG00000105298.13","CACTIN","chr19","-",3614385,3614589,3614396,3614589,3613463,3613586,632,"25,29",173178,"22,35",201217,160,149,0.599013092842,1,"0.119,0.132","0.092,0.131",0.014]
[633,"ENSG00000064961.18","HMG20B","chr19","+",3573691,3574586,3573691,3573800,3575539,3575660,633,628727,"1,0",809826,"1,0",298,149,1,1,"0.997,1.0","0.998,1.0",-1E-3]
[634,"ENSG00000064961.18","HMG20B","chr19","+",3573691,3574586,3573691,3573800,3576552,3576625,634,115115,"0,0",305275,"0,4",298,149,0.909971545285,1,"1.0,1.0","1.0,0.972",0.014]
[635,"ENSG00000105325.13","FZR1","chr19","+",3534420,3534522,3534420,3534513,3534794,3534836,635,"23,16",185165,"30,34",152145,158,149,0.0046770201035,0.0201745718818977,"0.105,0.084","0.157,0.181",-0.074]
[636,"ENSG00000099875.14","MKNK2","chr19","-",2051095,2051244,2051217,2051244,2050800,2050947,636,"115,90","0,0",136133,"0,1",271,149,1,1,"1.0,1.0","1.0,0.987",0.006]
[637,"ENSG00000133275.15","CSNK1G2","chr19","+",1979494,1979643,1979494,1979618,1979751,1979835,637,856840,"12,11",760813,"38,24",174,149,{"v":1.74292430388e-05,"d":"1.74E-05"},0.000140347153152253,"0.984,0.985","0.945,0.967",0.028]
[638,"ENSG00000129968.15","ABHD17A","chr19","-",1878663,1880115,1879920,1880115,1877507,1877687,638,"51,60",558719,183210,247243,298,149,0,0,"0.044,0.04","0.27,0.302",-0.244]
[639,"ENSG00000071564.14","TCF3","chr19","-",1615284,1615821,1615685,1615821,1612206,1612430,639,"45,48","38,26","59,45","24,40",298,149,0.721825128091,1,"0.372,0.48","0.551,0.36",-0.03]
[640,"ENSG00000071564.14","TCF3","chr19","-",1631950,1632116,1632037,1632116,1627358,1627426,640,"55,72",676734,"40,84",333322,236,149,{"v":2.49769498719E-5,"d":"2.50E-05"},0.000195843123300576,"0.049,0.058","0.07,0.141",-0.052]
[642,"ENSG00000119559.15","C19orf25","chr19","-",1478653,1478905,1478773,1478905,1461142,1461824,642,"21,33","59,43","50,59","13,21",269,149,{"v":1.10321773938e-09,"d":"1.10E-09"},{"v":1.80920982320884E-8,"d":"1.81E-08"},"0.165,0.298","0.681,0.609",-0.414]
[643,"ENSG00000115286.19","NDUFS7","chr19","+",1388832,1391050,1388832,1388938,1391118,1391165,643,11311407,"0,0",8681072,"1,0",298,149,1,1,"1.0,1.0","0.998,1.0",1E-3]
[644,"ENSG00000099622.13","CIRBP","chr19","+",1271139,1271467,1271139,1271365,1271550,1271632,644,12801261,"11,12",15121908,"55,59",251,149,{"v":5.4200858246e-09,"d":"5.42E-09"},{"v":7.98757305493791e-08,"d":"7.99E-08"},"0.986,0.984","0.942,0.95",0.039]
[645,"ENSG00000118046.14","STK11","chr19","+",1221212,1222006,1221212,1221340,1222984,1223172,645,754688,"0,3",549582,"0,0",298,149,1,1,"1.0,0.991","1.0,1.0",-0.004]
[646,"ENSG00000180448.10","ARHGAP45","chr19","+",1080254,1080547,1080254,1080379,1080681,1080786,646,220279,"6,0",263291,"5,1",298,149,0.890851631614,1,"0.948,1.0","0.963,0.993",-0.004]
[647,"ENSG00000064666.14","CNN2","chr19","+",1032558,1032669,1032558,1032663,1036129,1036246,647,"37,32","25,23","31,35","14,10",155,149,0.0370128310508,0.117319987166914,"0.587,0.572","0.68,0.771",-0.146]
[648,"ENSG00000064666.14","CNN2","chr19","+",1032558,1032696,1032558,1032663,1036129,1036246,648,19321879,"25,23",12641285,"14,10",182,149,0.237980480441,0.528747213668789,"0.984,0.985","0.987,0.991",-0.005]
[649,"ENSG00000064666.14","CNN2","chr19","+",1032558,1032696,1032558,1032669,1036129,1036246,649,19041853,"9,6",12331258,"0,8",176,149,1,1,"0.994,0.996","1.0,0.993",-1E-3]
[650,"ENSG00000182087.13","TMEM259","chr19","-",1012065,1012573,1012462,1012573,1011891,1011992,650,903954,"0,0",11401268,"2,0",298,149,1,1,"1.0,1.0","0.997,1.0",2E-3]
[651,"ENSG00000011304.19","PTBP1","chr19","+",805012,807902,805012,805187,808359,808452,651,31013311,"1,0",42684638,"1,7",298,149,1,1,"0.999,1.0","1.0,0.997",1E-3]
[652,"ENSG00000070423.17","RNF126","chr19","-",651610,651855,651691,651855,650233,650296,652,618772,"77,69",490606,"67,37",230,149,0.541128704854,0.956689223262242,"0.839,0.879","0.826,0.914",-0.011]
[653,"ENSG00000282508.1","LINC01002","chr19","-",203870,204065,203874,204065,201755,201813,653,"5,0","10,5","5,1","5,7",153,149,0.513510795812,0.918877855694533,"0.327,0.0","0.493,0.122",-0.144]
[662,"ENSG00000197563.10","PIGN","chr18","-",62088390,62088842,62088755,62088842,62085208,62085264,662,"0,0",71101,"3,3","29,31",298,149,0.0612957811649,0.178125341375471,"0.0,0.0","0.049,0.046",-0.048]
[667,"ENSG00000066926.10","FECH","chr18","-",57580054,57580199,57580072,57580199,57571391,57571540,667,"0,1","0,0","6,5","24,4",167,149,1,1,"NA,1.0","0.182,0.527",0.645]
[668,"ENSG00000066926.10","FECH","chr18","-",57580054,57580199,57580072,57580199,57573245,57573365,668,"25,22",264297,"81,69",349363,167,149,{"v":1.73196843312e-06,"d":"1.73E-06"},{"v":1.70315506430575e-05,"d":"1.70E-05"},"0.078,0.062","0.172,0.145",-0.088]
[670,"ENSG00000166845.14","C18orf54","chr18","+",54361642,54361948,54361642,54361891,54362770,54362921,670,"28,16","15,19","30,12","14,14",206,149,0.811283611093,1,"0.574,0.379","0.608,0.383",-0.019]
[671,"ENSG00000166845.14","C18orf54","chr18","+",54361642,54362431,54361642,54361891,54362770,54362921,671,"59,75","15,19","89,54","14,14",298,149,0.408689637016,0.790485996946804,"0.663,0.664","0.761,0.659",-0.046]
[672,"ENSG00000166845.14","C18orf54","chr18","+",54361642,54362431,54361642,54361948,54362770,54362921,672,"61,71","9,3","97,67","3,1",298,149,0.0105394026082,0.0408734294372803,"0.772,0.922","0.942,0.971",-0.109]
[674,"ENSG00000154832.14","CXXC1","chr18","-",50284719,50284839,50284731,50284839,50284377,50284562,674,"22,31",562626,"37,45",752796,161,149,0.37848581204,0.746562223308822,"0.035,0.044","0.044,0.05",-0.007]
[675,"ENSG00000154832.14","CXXC1","chr18","-",50285748,50286257,50286021,50286257,50285324,50285351,675,639688,"0,0",580638,"2,0",298,149,1,1,"1.0,1.0","0.993,1.0",0.004]
[676,"ENSG00000141644.17","MBD1","chr18","-",50272823,50272955,50272847,50272955,50272676,50272738,676,502395,"4,0",454518,"2,1",173,149,1,1,"0.991,1.0","0.995,0.998",-1E-3]
[677,"ENSG00000141644.17","MBD1","chr18","-",50276661,50276998,50276831,50276998,50276377,50276418,677,216224,"0,0",332286,"1,1",298,149,1,1,"1.0,1.0","0.994,0.993",0.006]
[678,"ENSG00000141644.17","MBD1","chr18","-",50279875,50280017,50279882,50280017,50277089,50277204,678,"0,2",235281,"16,6",336345,156,149,0.00108702842784,0.00570451308619644,"0.0,0.007","0.044,0.016",-0.026]
[679,"ENSG00000167315.17","ACAA2","chr18","-",49813681,49813953,49813816,49813953,49802686,49802853,679,"36,20","6,6","56,51","6,1",284,149,0.0178176521872,0.0643661189489246,"0.759,0.636","0.83,0.964",-0.2]
[680,"ENSG00000134030.13","CTIF","chr18","+",48757918,48758411,48757918,48758405,48761389,48761689,680,"10,13","26,27","25,28","51,49",155,149,0.476984344576,0.869728403211628,"0.27,0.316","0.32,0.355",-0.044]
[681,"ENSG00000267228.7","AC012254.2","chr18","-",47136301,47136449,47136338,47136449,47134655,47134704,681,"49,37",212278,"34,34","93,74",186,149,{"v":9.31458016661e-05,"d":"9.31E-05"},0.000642347778412758,"0.156,0.096","0.227,0.269",-0.122]
[682,"ENSG00000152234.15","ATP5F1A","chr18","-",46089822,46089996,46089888,46089996,46089565,46089732,682,66096106,"34,61",44364685,"24,23",215,149,0.477615337903,0.870583836862161,"0.993,0.986","0.992,0.993",-0.003]
[683,"ENSG00000152234.15","ATP5F1A","chr18","-",46094979,46095131,46095052,46095131,46091681,46091851,683,"23,19",38614201,"92,92",26632757,222,149,{"v":4.4737291649e-10,"d":"4.47E-10"},{"v":7.7376814077161e-09,"d":"7.74E-09"},"0.004,0.003","0.023,0.022",-0.019]
[684,"ENSG00000152234.15","ATP5F1A","chr18","-",46094979,46095131,46095052,46095131,46093179,46093362,684,"19,16","1,2","86,83","0,0",222,149,0.286304321581,0.610584622937126,"0.927,0.843","1.0,1.0",-0.115]
[685,"ENSG00000152234.15","ATP5F1A","chr18","-",46097835,46098353,46098171,46098353,46095052,46095123,685,"13,16","7,10",124107,"3,0",298,149,{"v":2.47468712189E-13,"d":"2.47E-13"},{"v":5.99610001290374e-12,"d":"6.00E-12"},"0.481,0.444","0.954,1.0",-0.514]
[700,"ENSG00000154040.20","CABYR","chr18","+",24155700,24156999,24155700,24156042,24159471,24160069,700,"0,4","0,1","0,1","0,0",298,149,1,1,"NA,0.667","NA,1.0",-0.333]
[717,"ENSG00000141562.17","NARF","chr17","+",82459991,82460323,82459991,82460072,82464286,82464430,717,"22,23",432370,203212,270311,298,149,0,0,"0.025,0.03","0.273,0.254",-0.236]
[729,"ENSG00000183010.16","PYCR1","chr17","-",81937179,81937239,81937192,81937239,81936747,81936861,729,"42,32","1,0","15,3","0,1",162,149,1,1,"0.975,1.0","1.0,0.734",0.121]
[733,"ENSG00000175866.15","BAIAP2","chr17","+",81053667,81053743,81053667,81053739,81057880,81057967,733,112116,"2,0","76,97","0,0",153,149,1,1,"0.982,1.0","1.0,1.0",-0.009]
[753,"ENSG00000167895.14","TMC8","chr17","+",78131280,78131737,78131280,78131405,78132358,78132508,753,140166,"5,7",220308,"0,0",298,149,{"v":3.26978826091e-05,"d":"3.27E-05"},0.000251259872220498,"0.933,0.922","1.0,1.0",-0.073]
[756,"ENSG00000167895.14","TMC8","chr17","+",78137234,78137814,78137234,78137323,78138004,78138071,756,592528,"1,0",560638,"0,0",298,149,1,1,"0.997,1.0","1.0,1.0",-2E-3]
[766,"ENSG00000132470.13","ITGB4","chr17","+",75740357,75740498,75740357,75740461,75740792,75740851,766,"2,0","0,0","0,0","0,2",186,149,1,1,"1.0,NA","NA,0.0",1]
[789,"ENSG00000133195.11","SLC39A11","chr17","-",72947730,72947875,72947751,72947875,72736649,72736719,789,"10,13","4,8","12,22","11,5",170,149,0.875047199871,1,"0.687,0.588","0.489,0.794",-0.004]
[792,"ENSG00000133195.11","SLC39A11","chr17","-",72947527,72947875,72947751,72947875,72849633,72849804,792,"9,17",96107,"15,26",91119,298,149,0.125359186024,0.314655651713997,"0.045,0.074","0.076,0.098",-0.027]
[810,"ENSG00000266173.6","STRADA","chr17","-",63713405,63713527,63713459,63713527,63710727,63710836,810,435410,"2,0",326341,"0,2",203,149,1,1,"0.994,1.0","1.0,0.992",1E-3]
[828,"ENSG00000108406.9","DHX40","chr17","+",59566626,59566794,59566626,59566709,59573739,59573967,828,213194,"0,0",291315,"0,2",234,149,1,1,"1.0,1.0","1.0,0.99",0.005]
[834,"ENSG00000169169.14","CPT1C","chr19","+",49691820,49691953,49691820,49691889,49692238,49692393,834,"2,0","0,0","0,0","1,0",213,149,1,1,"1.0,NA","0.0,NA",1]
[862,"ENSG00000108468.14","CBX1","chr17","-",48075988,48076178,48076000,48076178,48075005,48075100,862,"3,6",543473,"10,12",664781,161,149,0.385551038749,0.756614023141507,"0.005,0.012","0.014,0.014",-0.005]
[863,"ENSG00000108465.14","CDK5RAP3","chr17","+",47971121,47971171,47971121,47971152,47971361,47971407,863,"0,4",299295,"6,3",228315,168,149,0.861119418171,1,"0.0,0.012","0.023,0.008",-0.009]
[873,"ENSG00000141279.15","NPEPPS","chr17","+",47579389,47579511,47579389,47579455,47582741,47582849,873,833683,"11,6",455485,"15,4",205,149,0.11135811512,0.285916611565861,"0.982,0.988","0.957,0.989",0.012]
[891,"ENSG00000161682.14","FAM171A2","chr17","-",44358944,44359143,44359061,44359143,44356429,44356588,891,"13,8","0,0","11,20","1,0",266,149,1,1,"1.0,1.0","0.86,1.0",0.07]
[906,"ENSG00000012048.21","BRCA1","chr17","-",43091434,43094860,43094743,43094860,43090943,43091032,906,469416,"45,39",245296,"25,25",298,149,0.864888129785,1,"0.839,0.842","0.831,0.855",-2E-3]
[916,"ENSG00000126581.12","BECN1","chr17","-",42823704,42823879,42823747,42823879,42820773,42820841,916,"10,22",527497,"34,29",270272,192,149,{"v":2.93721048594e-08,"d":"2.94E-08"},{"v":3.84410102283972e-07,"d":"3.84E-07"},"0.015,0.033","0.089,0.076",-0.058]
[932,"ENSG00000168610.14","STAT3","chr17","-",42322281,42322494,42322284,42322494,42317181,42317224,932,11181046,266239,865973,248247,152,149,0.237877559975,0.52873694012625,"0.805,0.811","0.774,0.794",0.024]
[948,"ENSG00000131748.15","STARD3","chr17","+",39662250,39662367,39662250,39662344,39662803,39663484,948,"4,8",334355,"14,17",319349,172,149,0.00257577432356,0.0120794159428328,"0.01,0.019","0.037,0.04",-0.024]
[960,"ENSG00000172716.16","SLFN11","chr17","-",35367540,35367700,35367602,35367700,35366946,35367063,960,"32,18",105100,"2,10","12,6",211,149,0.23331744644,0.520752922987867,"0.177,0.113","0.105,0.541",-0.178]
[965,"ENSG00000005156.11","LIG3","chr17","+",34998603,34999449,34998603,34998727,35001256,35001403,965,"8,3","0,0","17,14","1,0",298,149,1,1,"1.0,1.0","0.895,1.0",0.052]
[974,"ENSG00000196535.16","MYO18A","chr17","-",29096760,29097350,29097222,29097350,29094935,29095059,974,"66,46","5,0","20,30","3,2",298,149,0.319760233339,0.66128039028469,"0.868,1.0","0.769,0.882",0.108]
[987,"ENSG00000244045.12","TMEM199","chr17","+",28360528,28360576,28360528,28360571,28360734,28360847,987,"2,0",277327,"1,2",329310,154,149,1,1,"0.007,0.0","0.003,0.006",-1E-3]
[1001,"ENSG00000131899.10","LLGL1","chr17","+",18236834,18237773,18236834,18236939,18238066,18238214,1001,148195,"0,1",139131,"1,0",298,149,1,1,"1.0,0.99","0.986,1.0",2E-3]
[1009,"ENSG00000141030.12","COPS3","chr17","-",17270757,17271008,17270895,17271008,17267884,17267977,1009,18441651,"26,18",723663,357315,287,149,0,0,"0.974,0.979","0.513,0.522",0.459]
[1030,"ENSG00000154914.16","USP43","chr17","+",9701351,9701700,9701351,9701685,9709955,9710114,1030,"3,13","2,5","3,11","1,4",164,149,0.708029779535,1,"0.577,0.703","0.732,0.714",-0.083]
[1040,"ENSG00000170037.13","CNTROB","chr17","+",7948486,7948685,7948486,7948619,7949081,7949157,1040,"4,13","56,52","28,13","66,78",215,149,0.0730966362684,0.204465317986335,"0.047,0.148","0.227,0.104",-0.068]
[1055,"ENSG00000258315.5","C17orf49","chr17","+",7016494,7016685,7016494,7016525,7016949,7017014,1055,429386,"3,4",470550,"2,1",298,149,0.935987708828,1,"0.986,0.98","0.992,0.996",-0.011]
[1060,"ENSG00000129235.10","TXNDC17","chr17","+",6641752,6641932,6641752,6641834,6642248,6642324,1060,"0,9",671711,"2,1",350457,247,149,1,1,"0.0,0.008","0.003,0.001",2E-3]
[1074,"ENSG00000141480.17","ARRB2","chr17","+",4719282,4719420,4719282,4719289,4720215,4720299,1074,22021796,"15,10",21012137,"1,3",280,149,0.855490218174,1,"0.987,0.99","0.999,0.997",-0.01]
[1089,"ENSG00000140995.16","DEF8","chr16","+",89949416,89949638,89949416,89949513,89954242,89954376,1089,"10,17","87,89","27,55","37,69",274,149,{"v":2.93186475098e-10,"d":"2.93E-10"},{"v":5.2220200316296E-9,"d":"5.22E-09"},"0.059,0.094","0.284,0.302",-0.216]
[1099,"ENSG00000167526.13","RPL13","chr16","+",89560939,89561368,89560939,89561063,89561577,89561751,1099,3077433917,"0,5",3437836701,"12,17",298,149,1,1,"1.0,1.0","0.999,0.999",1E-3]
[1120,"ENSG00000182944.17","EWSR1","chr22","+",29288605,29291599,29288605,29288786,29292136,29292169,1120,23742098,"5,13",16111758,"39,38",298,149,{"v":9.82824932549e-12,"d":"9.83E-12"},{"v":2.04907570239576e-10,"d":"2.05E-10"},"0.996,0.988","0.954,0.959",0.036]
[1129,"ENSG00000172530.20","BANP","chr16","+",87975047,87975207,87975047,87975203,87981035,87981127,1129,"9,20","9,11","5,5","5,5",153,149,0.464879900768,0.856366091175024,"0.493,0.639","0.493,0.493",0.073]
[1135,"ENSG00000135686.12","KLHL36","chr16","+",84656870,84657944,84656870,84657913,84659759,84659917,1135,"58,41","1,3","51,60","10,10",180,149,0.000787851754588,0.0042677286887501,"0.98,0.919","0.808,0.832",0.129]
[1162,"ENSG00000166747.12","AP1G1","chr16","-",71808504,71808832,71808762,71808832,71789278,71789482,1162,"25,26",160102,"63,42",204236,298,149,0.316312459758,0.656027590984124,"0.072,0.113","0.134,0.082",-0.016]
[1164,"ENSG00000102908.20","NFAT5","chr16","+",69647027,69647586,69647027,69647167,69653235,69653428,1164,131122,"5,0",423349,"1,0",298,149,0.199861077563,0.458053999237911,"0.929,1.0","0.995,1.0",-0.033]
[1182,"ENSG00000102878.16","HSF4","chr16","+",67165945,67166070,67165945,67166011,67166319,67166395,1182,"12,16","2,2","15,26","3,0",208,149,0.450612820953,0.841361679952225,"0.811,0.851","0.782,1.0",-0.06]
[1197,"ENSG00000166971.16","AKTIP","chr16","-",53502699,53503206,53503146,53503206,53500217,53500329,1197,"5,4","14,3","4,2","22,14",298,149,0.069941685381,0.197696440180976,"0.152,0.4","0.083,0.067",0.201]
[1223,"ENSG00000099364.16","FBXL19","chr16","+",30928466,30928630,30928466,30928628,30930072,30930584,1223,"0,1",143179,"0,2",142164,151,149,1,1,"0.0,0.005","0.0,0.012",-0.004]
[1243,"ENSG00000168488.18","ATXN2L","chr16","+",28826861,28826986,28826861,28826923,28829400,28829492,1243,19521930,"5,21",24852297,"6,1",212,149,0.73478675345,1,"0.996,0.985","0.997,0.999",-0.008]
[1249,"ENSG00000188603.19","CLN3","chr16","-",28482104,28482672,28482607,28482672,28477736,28477877,1249,508447,"0,0",212244,"31,26",298,149,0,0,"1.0,1.0","0.774,0.824",0.201]
[1258,"ENSG00000188603.19","CLN3","chr16","-",28482476,28482672,28482625,28482672,28482326,28482382,1258,310483,"0,0",161170,"6,11",298,149,{"v":2.79921739121e-08,"d":"2.80E-08"},{"v":3.6724366700777E-7,"d":"3.67E-07"},"1.0,1.0","0.931,0.885",0.092]
[1279,"ENSG00000170540.14","ARL6IP1","chr16","-",18798700,18798834,18798722,18798834,18797924,18798044,1279,25022528,"10,3",27392865,"0,3",171,149,1,1,"0.995,0.999","1.0,0.999",-0.003]
[1293,"ENSG00000188895.11","MSL1","chr17","+",40133041,40133658,40133041,40133109,40133826,40133899,1293,519534,"0,0",691752,"2,3",298,149,1,1,"1.0,1.0","0.994,0.992",0.007]
[1295,"ENSG00000033011.12","ALG1","chr16","+",5079063,5079106,5079063,5079102,5079747,5079807,1295,"3,9",242213,"17,8",112111,153,149,{"v":5.03377116706e-05,"d":"5.03E-05"},0.000366892345631649,"0.012,0.04","0.129,0.066",-0.072]
[1318,"ENSG00000215301.10","DDX3X","chrX","+",41342494,41342836,41342494,41342653,41344029,41344128,1318,"77,84","0,0",159177,"0,1",298,149,1,1,"1.0,1.0","1.0,0.989",0.006]
[1321,"ENSG00000215301.10","DDX3X","chrX","+",41347314,41347454,41347314,41347451,41347639,41349884,1321,"3,3",12731159,"3,2",11461162,152,149,1,1,"0.002,0.003","0.003,0.002",0]
[1341,"ENSG00000140988.15","RPS2","chr16","-",1962496,1962909,1962735,1962909,1962060,1962270,1341,3650637485,"39,22",3457442046,97118,298,149,1,1,"0.998,0.999","0.994,0.994",0.004]
[1355,"ENSG00000103249.17","CLCN7","chr16","-",1449275,1450666,1450496,1450666,1448965,1449093,1355,222173,"2,0",177186,"4,0",298,149,0.55588034435,0.970300853561779,"0.982,1.0","0.957,1.0",0.013]
[1370,"ENSG00000007376.7","RPUSD1","chr16","-",787353,787477,787396,787477,787076,787179,1370,301397,"0,7",173185,"5,2",192,149,0.30201412071,0.634831557365803,"1.0,0.978","0.964,0.986",0.014]
[1379,"ENSG00000140983.13","RHOT2","chr16","+",671859,672181,671859,672002,672253,672825,1379,348396,"0,0",266265,"0,4",298,149,0.676870290474,1,"1.0,1.0","1.0,0.971",0.014]
[1393,"ENSG00000242612.6","DECR2","chr16","+",406684,406952,406684,406833,407424,407560,1393,"6,4","1,0","2,5","0,4",268,149,0.0166781603464,0.0609869643122267,"0.769,1.0","1.0,0.41",0.18]
[1397,"ENSG00000103202.12","NME4","chr16","+",398207,398394,398207,398385,398989,399123,1397,"48,63","30,26","23,11","15,8",158,149,0.421827372205,0.808051793123466,"0.601,0.696","0.591,0.565",0.071]
[1416,"ENSG00000100284.20","TOM1","chr22","+",35321958,35322037,35321958,35322019,35323027,35323177,1416,130111,"0,1",146143,"8,4",167,149,0.00314635135665,0.0143425626673053,"1.0,0.99","0.942,0.97",0.039]
[1426,"ENSG00000140854.12","KATNB1","chr16","+",57736977,57737283,57736977,57737063,57741686,57741817,1426,651724,"0,2",270280,"0,0",298,149,1,1,"1.0,0.995","1.0,1.0",-2E-3]
[1436,"ENSG00000181991.15","MRPS11","chr15","+",88467907,88469145,88467907,88468024,88472354,88472620,1436,"66,64","36,23",165177,"52,46",298,149,0.0568295384249,0.167224336535851,"0.478,0.582","0.613,0.658",-0.105]
[1446,"ENSG00000164062.12","APEH","chr3","+",49676055,49676515,49676055,49676219,49676608,49676700,1446,12951289,"28,16",180153,"41,17",298,149,0,0,"0.959,0.976","0.687,0.818",0.215]
[1461,"ENSG00000144199.11","FAHD2B","chr2","-",97085698,97086198,97086138,97086198,97084168,97084277,1461,307308,"1,2","71,72","1,2",298,149,0.469623468405,0.862151753088906,"0.994,0.987","0.973,0.947",0.03]
[1469,"ENSG00000178904.18","DPY19L3","chr19","+",32467473,32468813,32467473,32467626,32477521,32477654,1469,305343,"1,1","37,26","0,0",298,149,1,1,"0.993,0.994","1.0,1.0",-0.006]
[1488,"ENSG00000028310.17","BRD9","chr5","-",892086,892522,892420,892522,891639,891854,1488,"15,12","4,1","12,7","0,0",298,149,0.000383270575184,0.00227802477780633,"0.652,0.857","1.0,1.0",-0.246]
[1505,"ENSG00000250155.1","AC008957.1","chr5","-",36705679,36705851,36705720,36705851,36668564,36668711,1505,"17,9","1,0","15,8","1,0",190,149,1,1,"0.93,1.0","0.922,1.0",0.004]
[1519,"ENSG00000135297.15","MTO1","chr6","+",73479731,73480126,73479731,73479844,73480674,73480805,1519,247185,"1,0",175123,"0,0",298,149,1,1,"0.992,1.0","1.0,1.0",-0.004]
[1528,"ENSG00000053900.10","ANAPC4","chr4","+",25405572,25405622,25405572,25405619,25406828,25406885,1528,"22,48",168162,"21,26",162153,152,149,0.171110568062,0.402978872857048,"0.114,0.225","0.113,0.143",0.042]
[1540,"ENSG00000106462.10","EZH2","chr7","-",148846469,148846598,148846496,148846598,148832633,148832750,1540,513476,111118,256255,"34,38",176,149,0.00341511180285,0.0152954924125979,"0.796,0.774","0.864,0.85",-0.072]
[1546,"ENSG00000103174.12","NAGPA","chr16","-",5027134,5027379,5027277,5027379,5024871,5025685,1546,143123,"0,0",124135,"0,1",292,149,1,1,"1.0,1.0","1.0,0.986",0.007]
[1562,"ENSG00000168395.15","ING5","chr2","+",241711376,241711584,241711376,241711488,241711977,241712071,1562,"14,2","118,82","6,11",171129,245,149,0.426820782538,0.812984769572203,"0.067,0.015","0.021,0.049",0.006]
[1568,"ENSG00000118418.14","HMGN3","chr6","-",79202275,79202389,79202316,79202389,79201244,79201726,1568,22411924,1106870,23232683,414437,190,149,0,0,"0.614,0.634","0.815,0.828",-0.197]
[1587,"ENSG00000065029.14","ZNF76","chr6","+",35290640,35291403,35290640,35290716,35291557,35291737,1587,209201,"0,0",222180,"0,1",298,149,1,1,"1.0,1.0","1.0,0.989",0.006]
[1600,"ENSG00000167595.15","PROSER3","chr19","+",35762252,35762477,35762252,35762356,35764853,35764936,1600,"16,36",108129,"40,21",118108,270,149,0.362447355772,0.725448770287152,"0.076,0.133","0.158,0.097",-0.023]
[1614,"ENSG00000137404.14","NRM","chr6","-",30690024,30690243,30690046,30690243,30689275,30689452,1614,"11,23",194280,"4,12",150160,171,149,0.23008673221,0.515038090951972,"0.047,0.067","0.023,0.061",0.015]
[1621,"ENSG00000254087.7","LYN","chr8","+",55941854,55941991,55941854,55941928,55946447,55946493,1621,1005893,410372,535555,205220,212,149,0.646606219905,1,"0.633,0.628","0.647,0.639",-0.012]
[1636,"ENSG00000174197.16","MGA","chr15","+",41736180,41736698,41736180,41736368,41740052,41740203,1636,193156,"3,3",261278,"4,4",298,149,0.894556524033,1,"0.97,0.963","0.97,0.972",-0.005]
[1657,"ENSG00000108433.16","GOSR2","chr17","+",46923159,46923387,46923159,46923221,46929519,46929584,1657,"5,0",301300,"3,11",352389,298,149,0.921941353753,1,"0.008,0.0","0.004,0.014",-0.005]
[1663,"ENSG00000175193.13","PARL","chr3","-",183862696,183862801,183862752,183862801,183856431,183856551,1663,"16,11","8,0","14,10","0,1",205,149,0.00408948723826,0.0180011062639938,"0.592,1.0","1.0,0.879",-0.143]
[1673,"ENSG00000198721.12","ECI2","chr6","-",4125249,4126237,4126134,4126237,4117307,4117451,1673,"32,29","0,0","33,24","3,5",298,149,{"v":3.84502507819E-5,"d":"3.85E-05"},0.000288860194072402,"1.0,1.0","0.846,0.706",0.224]
[1688,"ENSG00000131469.14","RPL27","chr17","+",42998418,43000102,42998418,42998471,43002672,43002783,1688,1529716562,"0,0",1419716348,"1,5",298,149,1,1,"1.0,1.0","1.0,0.999",0]
[1698,"ENSG00000197157.10","SND1","chr7","+",128089488,128089825,128089488,128089692,128091836,128091881,1698,"15,23",12171194,"49,35",9921080,282,149,{"v":3.87618281866e-05,"d":"3.88E-05"},0.000290389796400726,"0.006,0.01","0.025,0.017",-0.013]
[1716,"ENSG00000111653.19","ING4","chr12","-",6652935,6653050,6652944,6653050,6652661,6652767,1716,162215,"40,65",360458,130130,158,149,0.366526692058,0.731537613125836,"0.793,0.757","0.723,0.769",0.029]
[1721,"ENSG00000113643.8","RARS","chr5","+",168492658,168492847,168492658,168492791,168493893,168494002,1721,12951147,"0,0",607467,"0,1",205,149,1,1,"1.0,1.0","1.0,0.997",2E-3]
[1740,"ENSG00000111678.10","C12orf57","chr12","+",6944475,6944652,6944475,6944565,6945770,6946002,1740,33353396,374442,51795543,477543,236,149,0.0314339207668,0.102848576523489,"0.849,0.829","0.873,0.866",-0.03]
[1755,"ENSG00000167967.15","E4F1","chr16","+",2234858,2235001,2234858,2234949,2235080,2235143,1755,283356,"1,0",243242,"0,1",201,149,1,1,"0.995,1.0","1.0,0.994",1E-3]
[1766,"ENSG00000055163.19","CYFIP2","chr5","+",157287018,157287108,157287018,157287074,157294782,157294860,1766,197250,"0,0",237221,"1,0",183,149,1,1,"1.0,1.0","0.995,1.0",2E-3]
[1775,"ENSG00000120705.12","ETF1","chr5","-",138542633,138542936,138542704,138542936,138518691,138518867,1775,"12,4","11,4","23,30","5,17",220,149,0.0671759377101,0.191488801771397,"0.425,0.404","0.757,0.544",-0.236]
[1794,"ENSG00000117523.16","PRRC2C","chr1","+",171584418,171584541,171584418,171584526,171587002,171587221,1794,584522,14201425,424341,10881114,164,149,0.313532892823,0.652147446665888,"0.272,0.25","0.261,0.218",0.022]
[1806,"ENSG00000101187.15","SLCO4A1","chr20","+",62667744,62668541,62667744,62667910,62668929,62669078,1806,361340,"0,0",145152,"1,1",298,149,1,1,"1.0,1.0","0.986,0.987",0.014]
[1820,"ENSG00000185324.21","CDK10","chr16","+",89694930,89695070,89694930,89695052,89695292,89695345,1820,579600,"26,28",425465,"23,27",167,149,0.382556618817,0.752384662748315,"0.952,0.95","0.943,0.939",0.01]
[1833,"ENSG00000077312.8","SNRPA","chr19","+",40757331,40757504,40757331,40757441,40758783,40758869,1833,1060970,"0,0",804898,"2,0",212,149,1,1,"1.0,1.0","0.996,1.0",2E-3]
[1842,"ENSG00000164308.16","ERAP2","chr5","+",96909579,96909809,96909579,96909764,96912636,96912798,1842,"0,4","0,0","1,2","4,1",194,149,1,1,"NA,1.0","0.161,0.606",0.617]
[1855,"ENSG00000127249.14","ATP13A4","chr3","-",193440489,193440637,193440557,193440637,193439022,193439065,1855,"8,1","5,2","2,4","0,0",217,149,{"v":9.9624000871e-07,"d":"9.96E-07"},{"v":1.01877851841275E-5,"d":"1.02E-05"},"0.523,0.256","1.0,1.0",-0.611]
[1870,"ENSG00000165410.14","CFL2","chr14","-",34713253,34713561,34713396,34713561,34713059,34713136,1870,114148,"2,1",93108,"6,5",292,149,0.00316728091925,0.014389192622167,"0.967,0.987","0.888,0.917",0.074]
[1875,"ENSG00000185513.16","L3MBTL1","chr20","+",43530283,43532924,43530283,43530419,43533341,43533418,1875,"64,38","0,0","55,31","1,0",298,149,1,1,"1.0,1.0","0.965,1.0",0.018]
[1898,"ENSG00000160310.17","PRMT2","chr21","+",46660832,46661936,46660832,46660962,46663382,46663554,1898,323236,"0,1",107107,"0,2",298,149,0.967165594186,1,"1.0,0.992","1.0,0.964",0.014]
[1903,"ENSG00000172262.11","ZNF131","chr5","+",43123208,43123310,43123208,43123250,43139164,43139309,1903,540511,"1,0",483456,"1,0",209,149,1,1,"0.997,1.0","0.997,1.0",0]
[1923,"ENSG00000135409.10","AMHR2","chr12","+",53425454,53425573,53425454,53425487,53425688,53425919,1923,"21,20","62,42","28,55","18,25",235,149,{"v":1.41326024217E-8,"d":"1.41E-08"},{"v":1.95925949552382e-07,"d":"1.96E-07"},"0.177,0.232","0.497,0.582",-0.335]
[1936,"ENSG00000167721.10","TSR1","chr17","-",2335259,2335394,2335307,2335394,2334471,2334896,1936,783696,"9,6",269290,"1,7",197,149,0.744177474759,1,"0.985,0.989","0.995,0.969",0.005]
[1950,"ENSG00000188917.14","TRMT2B","chrX","-",101042041,101042312,101042232,101042312,101041316,101041371,1950,153149,"62,35","21,25","6,0",298,149,0.0472192030547,0.143336395728685,"0.552,0.68","0.636,1.0",-0.202]
[1956,"ENSG00000154124.4","OTULIN","chr5","+",14681463,14681624,14681463,14681607,14687520,14687646,1956,"31,30",314279,"34,54",350287,166,149,0.134745153653,0.332779697658166,"0.081,0.088","0.08,0.144",-0.027]
[1975,"ENSG00000166598.14","HSP90B1","chr12","+",103942526,103943319,103942526,103942796,103943737,103943874,1975,78107100,"0,0",46234858,"0,1",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[1980,"ENSG00000249915.7","PDCD6","chr5","+",306601,306760,306601,306754,311292,311402,1980,803695,179159,426483,144135,155,149,0.0233096401372,0.0804249867209742,"0.812,0.808","0.74,0.775",0.052]
[1999,"ENSG00000110719.9","TCIRG1","chr11","+",68047646,68047972,68047646,68047804,68048878,68048997,1999,301274,"0,0",382395,"4,16",298,149,{"v":3.86806489313e-05,"d":"3.87E-05"},2.90185788844438E-4,"1.0,1.0","0.979,0.925",0.048]
[2005,"ENSG00000141994.15","DUS3L","chr19","-",5786748,5787171,5787060,5787171,5786466,5786542,2005,439386,"24,5",359333,"13,18",298,149,0.36896536476,0.733973630563624,"0.901,0.975","0.932,0.902",0.021]
[2019,"ENSG00000145425.9","RPS3A","chr4","+",151100974,151101162,151100974,151101012,151102870,151103079,2019,6235956404,"13,10",6667968127,"10,6",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[2035,"ENSG00000198755.10","RPL10A","chr6","+",35468798,35469027,35468798,35468873,35470178,35470351,2035,180209,"0,0",227233,"1,1",298,149,1,1,"1.0,1.0","0.991,0.991",0.009]
[2051,"ENSG00000082074.16","FYB1","chr5","-",39125971,39126135,39125997,39126135,39124252,39124278,2051,"19,11","109,80","8,4","39,38",175,149,0.832940870299,1,"0.129,0.105","0.149,0.082",2E-3]
[2057,"ENSG00000155508.13","CNOT8","chr5","+",154858638,154858816,154858638,154858801,154865191,154865385,2057,"25,23","16,2","44,53","12,4",164,149,0.272182538641,0.587507975662094,"0.587,0.913","0.769,0.923",-0.096]
[2073,"ENSG00000174720.15","LARP7","chr4","+",112644667,112644871,112644667,112644699,112646350,112646451,2073,876848,"7,2",607628,"0,0",298,149,1,1,"0.984,0.995","1.0,1.0",-0.01]
[2084,"ENSG00000138698.14","RAP1GDS1","chr4","+",98343138,98343319,98343138,98343261,98404476,98404602,2084,"5,8","0,0","3,14","0,2",207,149,0.630564768608,1,"1.0,1.0","1.0,0.834",0.083]
[2094,"ENSG00000143436.10","MRPL9","chr1","-",151762954,151763146,151762989,151763146,151762375,151762500,2094,"21,16",850792,"16,4",590669,184,149,0.203563287061,0.464756757682987,"0.02,0.016","0.021,0.005",0.005]
[2116,"ENSG00000163743.13","RCHY1","chr4","-",75491582,75491637,75491610,75491637,75490580,75490701,2116,"8,2",474381,"5,11",344291,177,149,0.0792311945845,0.217885785107375,"0.014,0.004","0.012,0.031",-0.012]
[2135,"ENSG00000165915.13","SLC39A13","chr11","+",47414776,47414909,47414776,47414905,47415059,47415159,2135,"21,55","1,0","38,47","1,0",153,149,1,1,"0.953,1.0","0.974,1.0",-0.011]
[2138,"ENSG00000161013.16","MGAT4B","chr5","-",179798927,179799121,179799064,179799121,179798512,179798591,2138,17201754,"4,2",13971482,"1,10",286,149,1,1,"0.996,0.998","0.999,0.987",0.004]
[2153,"ENSG00000198792.12","TMEM184B","chr22","-",38246784,38246885,38246805,38246885,38245934,38246100,2153,"3,2","2,1","0,6","1,0",170,149,0.0465826555067,0.142045410414137,"0.568,0.637","0.0,1.0",0.103]
[2162,"ENSG00000109180.14","OCIAD1","chr4","+",48831226,48831496,48831226,48831398,48833400,48833481,2162,"62,76","0,0",107183,"0,1",247,149,1,1,"1.0,1.0","1.0,0.991",0.004]
[2175,"ENSG00000157796.17","WDR19","chr4","+",39232161,39232308,39232161,39232272,39234765,39234875,2175,"3,0","31,22","0,0","11,4",185,149,0.637050487284,1,"0.072,0.0","0.0,0.0",0.036]
[2188,"ENSG00000270647.5","TAF15","chr17","+",35809483,35809616,35809483,35809576,35817715,35817755,2188,"3,5",10251028,"3,4",512545,189,149,1,1,"0.002,0.004","0.005,0.006",-2E-3]
[2198,"ENSG00000169045.17","HNRNPH1","chr5","-",179617050,179617110,179617059,179617110,179616868,179616958,2198,56245309,"66,33",17651812,"17,18",158,149,0.753328265127,1,"0.988,0.993","0.99,0.99",0]
[2217,"ENSG00000134317.17","GRHL1","chr2","+",9990695,9990773,9990695,9990747,9992006,9992146,2217,"0,1","3,6","0,0","3,5",175,149,1,1,"0.0,0.124","0.0,0.0",0.062]
[2231,"ENSG00000151692.14","RNF144A","chr2","+",7020472,7020768,7020472,7020680,7024368,7024516,2231,"6,7",207202,"12,17",84103,237,149,{"v":3.44014759268e-06,"d":"3.44E-06"},{"v":3.18494903632112e-05,"d":"3.18E-05"},"0.018,0.021","0.082,0.094",-0.068]
[2239,"ENSG00000159692.15","CTBP1","chr4","-",1214190,1214473,1214342,1214473,1213477,1213605,2239,"24,32",11701399,"45,51",9451123,298,149,1.03408356519E-4,0.00070409310090595,"0.01,0.011","0.023,0.022",-0.012]
[2253,"ENSG00000185798.7","WDR53","chr3","-",196566889,196567307,196567190,196567307,196554193,196554807,2253,111110,"8,2",117181,"4,4",298,149,0.32028547327,0.662112052543939,"0.874,0.965","0.936,0.958",-0.028]
[2269,"ENSG00000136935.13","GOLGA1","chr9","-",124921711,124921892,124921722,124921892,124921128,124921240,2269,"7,1","129,72","6,3",115107,160,149,0.679953330706,1,"0.048,0.013","0.046,0.025",-0.005]
[2284,"ENSG00000156931.15","VPS8","chr3","+",184839697,184839758,184839697,184839752,184849070,184849195,2284,"0,0","73,41","2,1","25,27",155,149,0.566216921219,0.980601905684418,"0.0,0.0","0.071,0.034",-0.052]
[2296,"ENSG00000145191.13","EIF2B5","chr3","+",184140079,184140740,184140079,184140730,184141924,184142070,2296,"5,1",535527,"6,3",175128,159,149,0.0906911344603,0.241379323236988,"0.009,0.002","0.031,0.021",-0.021]
[2310,"ENSG00000204628.11","RACK1","chr5","-",181242173,181242345,181242285,181242345,181241491,181241639,2310,2228822381,"34,53",2211824020,"49,54",261,149,1,1,"0.997,0.996","0.996,0.996",0]
[2320,"ENSG00000105854.12","PON2","chr7","-",95416171,95416297,95416241,95416297,95412311,95412477,2320,"33,21",123140,"36,45","48,15",219,149,{"v":7.90772714676e-06,"d":"7.91E-06"},{"v":6.70909531899401e-05,"d":"6.71E-05"},"0.154,0.093","0.338,0.671",-0.381]
[2343,"ENSG00000114346.13","ECT2","chr3","+",172752149,172752472,172752149,172752436,172754508,172754660,2343,"3,6","6,4","0,1","0,0",185,149,1,1,"0.287,0.547","NA,1.0",-0.583]
[2350,"ENSG00000109332.19","UBE2D3","chr4","-",102801453,102802638,102802560,102802638,102799406,102799500,2350,42693996,"1,0",31993372,"12,7",298,149,1,1,"1.0,1.0","0.993,0.996",0.006]
[2359,"ENSG00000164068.15","RNF123","chr3","+",49712478,49712892,49712478,49712656,49713512,49713587,2359,"40,68",177176,"32,37","63,48",298,149,0.00135523520395,0.00695592572714413,"0.102,0.162","0.203,0.278",-0.109]
[2377,"ENSG00000163660.11","CCNL1","chr3","-",157157006,157157083,157157010,157157083,157153035,157153156,2377,"3,4",172101,"2,8",81102,153,149,0.141866628508,0.346548862281803,"0.017,0.037","0.023,0.071",-0.02]
[2398,"ENSG00000110514.19","MADD","chr11","+",47284940,47285194,47284940,47285065,47286432,47286534,2398,"81,99","0,0",163168,"0,1",278,149,1,1,"1.0,1.0","1.0,0.989",0.006]
[2408,"ENSG00000140694.16","PARN","chr16","-",14628171,14628251,14628190,14628251,14610643,14610809,2408,"34,44","0,0","16,22","2,0",168,149,0.749558774859,1,"1.0,1.0","0.876,1.0",0.062]
[2422,"ENSG00000164896.19","FASTK","chr7","-",151077309,151077780,151077620,151077780,151076912,151077236,2422,236267,"0,0",175197,"0,1",298,149,1,1,"1.0,1.0","1.0,0.99",0.005]
[2432,"ENSG00000166562.8","SEC11C","chr18","+",59152535,59152685,59152535,59152612,59155687,59155807,2432,11211021,"4,11",11381324,"3,5",222,149,0.870165919853,1,"0.995,0.984","0.996,0.994",-0.005]
[2444,"ENSG00000169733.11","RFNG","chr17","-",82051011,82051342,82051293,82051342,82050661,82050764,2444,"28,27","96,96","29,53","97,91",298,149,0.080884081929,0.221299835552436,"0.127,0.123","0.13,0.226",-0.053]
[2453,"ENSG00000169714.16","CNBP","chr3","-",129171633,129171771,129171654,129171771,129171445,129171538,2453,12481176,24352403,10341141,26062534,170,149,0.111254223877,0.285786279959113,"0.31,0.3","0.258,0.283",0.035]
[2482,"ENSG00000172663.8","TMEM134","chr11","-",67468016,67468092,67468027,67468092,67467500,67467563,2482,"1,7","10,21","13,6","40,61",160,149,0.867059017301,1,"0.085,0.237","0.232,0.084",0.003]
[2486,"ENSG00000013375.15","PGM3","chr6","-",83170300,83170478,83170304,83170478,83164872,83169323,2486,"0,0",117140,"0,4","113,86",153,149,0.547697886738,0.963081704074436,"0.0,0.0","0.0,0.043",-0.021]
[2501,"ENSG00000155329.11","ZCCHC10","chr5","-",133026492,133026545,133026496,133026545,133022840,133022906,2501,"1,4","121,89","0,0","9,18",153,149,0.95324804255,1,"0.008,0.042","0.0,0.0",0.025]
[2514,"ENSG00000103051.18","COG4","chr16","-",70508405,70509388,70509230,70509388,70500957,70501091,2514,634579,"0,0",241217,"3,0",298,149,1,1,"1.0,1.0","0.976,1.0",0.012]
[2529,"ENSG00000162032.15","SPSB3","chr16","-",1777945,1778612,1778133,1778612,1777746,1777872,2529,126147,"0,0",135125,"3,7",298,149,0.000454957818325,0.00265137389465891,"1.0,1.0","0.957,0.899",0.072]
[2545,"ENSG00000215190.9","LINC00680","chr6","-",57948872,57949068,57948917,57949068,57946077,57947177,2545,138143,"5,5",329251,"17,12",194,149,0.251533782339,0.550671638258641,"0.955,0.956","0.937,0.941",0.016]
[2553,"ENSG00000132424.15","PNISR","chr6","-",99403828,99404702,99404602,99404702,99402539,99402710,2553,13991172,"67,33",16051712,176183,298,149,{"v":3.13649106687e-12,"d":"3.14E-12"},{"v":7.00049188742478e-11,"d":"7.00E-11"},"0.913,0.947","0.82,0.824",0.108]
[2570,"ENSG00000157036.12","EXOG","chr3","+",38497628,38497778,38497628,38497689,38498925,38498989,2570,"30,31","4,0","27,30","0,0",238,149,0.0618441110574,0.179138111673535,"0.824,1.0","1.0,1.0",-0.088]
[2581,"ENSG00000100949.14","RABGGTA","chr14","-",24267865,24267958,24267869,24267958,24267659,24267776,2581,"1,3",113110,"0,0","57,68",153,149,0.573743431328,0.989472881408564,"0.009,0.026","0.0,0.0",0.017]
[2597,"ENSG00000233355.6","CHRM3-AS2","chr1","-",239707533,239707760,239707614,239707760,239706424,239706496,2597,"47,40","6,0","17,12","0,0",230,149,0.00564134470626,0.0237811858738029,"0.835,1.0","1.0,1.0",-0.083]
[2617,"ENSG00000104763.18","ASAH1","chr8","-",18062247,18062423,18062278,18062423,18061685,18061740,2617,"21,10",22842013,"34,36",510496,180,149,0,0,"0.008,0.004","0.052,0.057",-0.049]
[2628,"ENSG00000104763.18","ASAH1","chr8","-",18084586,18084961,18084675,18084961,18075540,18075587,2628,"10,11","94,64","6,21","110,85",238,149,0.899192902983,1,"0.062,0.097","0.033,0.134",-0.004]
[2637,"ENSG00000102030.15","NAA10","chrX","-",153932070,153932431,153932315,153932431,153930762,153930847,2637,15081603,"6,2",10661315,"9,4",298,149,0.894093304452,1,"0.992,0.998","0.983,0.994",0.007]
[2653,"ENSG00000134644.15","PUM1","chr1","-",30941921,30942123,30941997,30942123,30941150,30941272,2653,"9,9",540516,"13,17",475461,225,149,0.0393082267881,0.123576243070245,"0.011,0.011","0.018,0.024",-0.01]
[2668,"ENSG00000271723.5","MROH7-TTC4","chr1","+",54731485,54731700,54731485,54731549,54733628,54733710,2668,979875,"0,0",896770,"7,7",298,149,0.29091673522,0.616921917128979,"1.0,1.0","0.985,0.982",0.016]
[2689,"ENSG00000131089.15","ARHGEF9","chrX","-",63754303,63755113,63754920,63755113,63706257,63706449,2689,"69,85","0,5","110,99","0,0",298,149,0.0563973967336,0.166407897438307,"1.0,0.895","1.0,1.0",-0.052]
[2706,"ENSG00000149182.14","ARFGAP2","chr11","-",47171425,47171557,47171452,47171557,47168122,47168251,2706,691561,"2,0",536629,"6,0",176,149,1,1,"0.997,1.0","0.987,1.0",0.005]
[2718,"ENSG00000163161.13","ERCC3","chr2","-",127291911,127292846,127292083,127292846,127290223,127290273,2718,"29,20","0,1",144102,"0,1",298,149,1,1,"1.0,0.909","1.0,0.981",-0.036]
[2719,"ENSG00000163161.13","ERCC3","chr2","-",127291911,127292846,127292609,127292846,127290223,127290273,2719,"18,38",297295,"124,66",182154,298,149,0,0,"0.029,0.061","0.254,0.176",-0.17]
[2740,"ENSG00000242086.8","MUC20-OT1","chr3","+",195708153,195708513,195708153,195708387,195708746,195708841,2740,"2,1","1,5","0,1","1,0",275,149,0.255334084864,0.557856231715457,"0.52,0.098","0.0,1.0",-0.191]
[2757,"ENSG00000109685.17","NSD2","chr4","+",1942338,1942565,1942338,1942432,1951071,1951203,2757,136105,"2,3",147148,"2,4",282,149,0.934587925586,1,"0.973,0.949","0.975,0.951",-2E-3]
[2761,"ENSG00000137955.15","RABGGTB","chr1","+",75789951,75790274,75789951,75790057,75791284,75791337,2761,512519,634549,9431035,354376,298,149,0,0,"0.288,0.321","0.571,0.579",-0.27]
[2780,"ENSG00000234741.7","GAS5","chr1","-",173864483,173864704,173864674,173864704,173864256,173864304,2780,75366916,602548,1153413328,11381267,298,149,0.0656981687044,0.188575479968499,"0.862,0.863","0.835,0.84",0.025]
[2789,"ENSG00000234741.7","GAS5","chr1","-",173865470,173865547,173865509,173865547,173864674,173864704,2789,834655,"25,23",12561390,779768,188,149,0,0,"0.964,0.958","0.561,0.589",0.386]
[2803,"ENSG00000157404.15","KIT","chr4","+",54725856,54726050,54725856,54726038,54727822,54727927,2803,"8,19","0,2","20,21","3,0",161,149,0.781265327769,1,"1.0,0.898","0.861,1.0",0.019]
[2816,"ENSG00000111752.10","PHC1","chr12","+",8932562,8933350,8932562,8932831,8933864,8934012,2816,217171,"7,15",249229,"12,11",298,149,0.651092462635,1,"0.939,0.851","0.912,0.912",-0.017]
[2819,"ENSG00000115355.16","CCDC88A","chr2","-",55299838,55301277,55301205,55301277,55296257,55296523,2819,478426,"16,28",266211,"17,34",298,149,0.00350797915274,0.0156203806809507,"0.937,0.884","0.887,0.756",0.089]
[2834,"ENSG00000141127.14","PRPSAP2","chr17","+",18856298,18856476,18856298,18856429,18872582,18872649,2834,"1,0","0,0","0,0","3,0",196,149,1,1,"1.0,NA","0.0,NA",1]
[2842,"ENSG00000261645.6","DISC1FP1","chr11","+",90844879,90844957,90844879,90844949,90852615,90852707,2842,"18,26",81117,"20,15",126105,157,149,0.143140846318,0.348899881614285,"0.174,0.174","0.131,0.119",0.049]
[2864,"ENSG00000168067.11","MAP4K2","chr11","-",64792171,64792422,64792363,64792422,64791908,64792086,2864,189159,"0,0","93,77","6,5",298,149,{"v":5.64045091234e-06,"d":"5.64E-06"},{"v":4.95751396364001e-05,"d":"4.96E-05"},"1.0,1.0","0.886,0.885",0.115]
[2879,"ENSG00000114021.11","NIT2","chr3","+",100345584,100346255,100345584,100345678,100348802,100348881,2879,691712,"10,0",137134,"0,0",298,149,0.799316386453,1,"0.972,1.0","1.0,1.0",-0.014]
[2893,"ENSG00000101019.21","UQCC1","chr20","-",35381917,35382025,35381983,35382025,35366556,35366614,2893,254226,"0,0",330266,"0,1",215,149,1,1,"1.0,1.0","1.0,0.995",2E-3]
[2907,"ENSG00000106052.13","TAX1BP1","chr7","+",27816348,27816520,27816348,27816394,27827737,27827820,2907,"56,62","1,3","16,25","7,5",275,149,0.00010253622345,0.000699039728691444,"0.968,0.918","0.553,0.73",0.302]
[2913,"ENSG00000120318.15","ARAP3","chr5","-",141671264,141671400,141671324,141671400,141670511,141670628,2913,"30,27","1,2","26,20","0,0",209,149,0.979593983029,1,"0.955,0.906","1.0,1.0",-0.07]
[2920,"ENSG00000204681.10","GABBR1","chr6","-",29630457,29630643,29630521,29630643,29629086,29629247,2920,"85,73","2,0","21,13","0,0",213,149,1,1,"0.967,1.0","1.0,1.0",-0.016]
[2933,"ENSG00000147465.11","STAR","chr8","-",38148199,38148754,38148640,38148754,38146288,38146447,2933,731658,"2,4",299332,"3,8",298,149,0.0134332261632,0.0503886496038025,"0.995,0.988","0.98,0.954",0.025]
[2947,"ENSG00000198805.11","PNP","chr14","+",20474471,20474948,20474471,20474575,20475061,20475252,2947,1126942,"0,0",681629,"0,1",298,149,1,1,"1.0,1.0","1.0,0.997",2E-3]
[2966,"ENSG00000145041.15","DCAF1","chr3","-",51466802,51466876,51466805,51466876,51463113,51463227,2966,348330,"2,0",362349,"2,0",152,149,1,1,"0.994,1.0","0.994,1.0",0]
[2981,"ENSG00000156869.13","FRRS1","chr1","-",99710805,99710949,99710833,99710949,99709197,99709259,2981,236238,"1,3",141177,"11,1",177,149,0.00533519737452,0.0227221113836445,"0.995,0.985","0.915,0.993",0.036]
[2987,"ENSG00000090621.13","PABPC4","chr1","-",39571096,39571349,39571233,39571349,39569862,39570002,2987,582549,32922964,416507,22692226,286,149,0.273541968943,0.589732365107974,"0.084,0.088","0.087,0.106",-0.011]
[3005,"ENSG00000130755.12","GMFG","chr19","-",39329543,39329626,39329547,39329626,39328999,39329073,3005,32682931,"23,28",19572146,"10,24",153,149,1,1,"0.993,0.99","0.995,0.989",0]
[3009,"ENSG00000115694.14","STK25","chr2","-",241501477,241501698,241501527,241501698,241500739,241500796,3009,1226909,"27,28",899789,"34,27",199,149,0.12238262894,0.308827753643105,"0.971,0.96","0.952,0.956",0.012]
[3019,"ENSG00000116906.12","GNPAT","chr1","+",231267679,231267911,231267679,231267903,231272311,231272391,3019,"1,3","4,0","1,2","15,10",157,149,0.0264945533166,0.0895188825167606,"0.192,1.0","0.06,0.16",0.486]
[3041,"ENSG00000153187.19","HNRNPU","chr1","-",244860352,244860474,244860357,244860474,244859274,244859374,3041,501408,"52,19",234249,"25,21",154,149,0.382220735776,0.751999026239613,"0.903,0.954","0.901,0.92",0.018]
[3043,"ENSG00000067829.18","IDH3G","chrX","-",153790795,153790851,153790809,153790851,153790194,153790292,3043,"3,10","5,1","6,8","0,0",163,149,0.00018239321778,0.00116519372736178,"0.354,0.901","1.0,1.0",-0.373]
[3056,"ENSG00000080503.23","SMARCA2","chr9","+",2158455,2158978,2158455,2158587,2159813,2159909,3056,"2,0","7,5","1,9","10,9",298,149,0.0270072658871,0.0909636821578321,"0.125,0.0","0.048,0.333",-0.128]
[3073,"ENSG00000136051.14","WASHC4","chr12","+",105133769,105133899,105133769,105133896,105137885,105138011,3073,"0,2",135164,"0,2","76,76",152,149,1,1,"0.0,0.012","0.0,0.025",-0.007]
[3080,"ENSG00000181038.13","METTL23","chr17","+",76733292,76733381,76733292,76733377,76733520,76733936,3080,"5,9",365281,"0,1",146142,153,149,0.0830064926654,0.226301025872877,"0.013,0.03","0.0,0.007",0.018]
[3098,"ENSG00000068654.15","POLR1A","chr2","-",86031329,86031635,86031512,86031635,86030195,86030396,3098,734599,"8,9",607533,"11,8",298,149,0.455327136834,0.847694204124568,"0.979,0.971","0.965,0.971",0.007]
[3112,"ENSG00000125520.13","SLC2A4RG","chr20","+",63742335,63742615,63742335,63742364,63742698,63742790,3112,490511,"2,6",316322,"0,2",298,149,0.892071845408,1,"0.992,0.977","1.0,0.988",-0.01]
[3116,"ENSG00000142303.13","ADAMTS10","chr19","-",8595761,8595903,8595772,8595903,8592762,8592870,3116,"14,3","6,8","6,10","0,0",160,149,{"v":1.04899050768E-6,"d":"1.05E-06"},{"v":1.07068689578951e-05,"d":"1.07E-05"},"0.685,0.259","1.0,1.0",-0.528]
[3142,"ENSG00000105640.12","RPL18A","chr19","+",17861292,17861472,17861292,17861307,17862093,17862223,3142,2682526703,"2,5",3850839214,"3,18",298,149,1,1,"1.0,1.0","1.0,0.999",0]
[3147,"ENSG00000166169.16","POLL","chr10","-",101584601,101584919,101584877,101584919,101583507,101583681,3147,266195,"11,18",181255,"3,3",298,149,{"v":6.63247786682e-05,"d":"6.63E-05"},0.000468805498628446,"0.924,0.844","0.968,0.977",-0.088]
[3160,"ENSG00000162909.17","CAPN2","chr1","+",223761580,223761739,223761580,223761617,223762185,223762251,3160,"1,0",185138,"0,0","141,87",271,149,1,1,"0.003,0.0","0.0,0.0",2E-3]
[3177,"ENSG00000152556.16","PFKM","chr12","+",48139284,48139504,48139284,48139349,48139848,48139912,3177,"18,18",296271,"47,22",177172,298,149,{"v":1.13263793666E-6,"d":"1.13E-06"},{"v":1.15169365997998E-5,"d":"1.15E-05"},"0.03,0.032","0.117,0.06",-0.057]
[3190,"ENSG00000092094.10","OSGEP","chr14","-",20448901,20449013,20448963,20449013,20448732,20448811,3190,"13,10",538549,89119,289475,211,149,0,0,"0.017,0.013","0.179,0.15",-0.149]
[3201,"ENSG00000115183.14","TANC1","chr2","+",159219237,159219867,159219237,159219361,159224231,159224364,3201,527480,"0,0",539615,"4,4",298,149,0.724711898416,1,"1.0,1.0","0.985,0.987",0.014]
[3209,"ENSG00000114779.19","ABHD14B","chr3","-",51971459,51971892,51971811,51971892,51969942,51970184,3209,637801,"0,0",205283,"1,0",298,149,1,1,"1.0,1.0","0.99,1.0",0.005]
[3215,"ENSG00000025800.13","KPNA6","chr1","+",32156852,32156945,32156852,32156927,32157345,32157445,3215,250232,"5,1",286238,"2,2",167,149,0.695079031758,1,"0.978,0.995","0.992,0.991",-0.005]
[3233,"ENSG00000116670.14","MAD2L2","chr1","-",11676808,11676948,11676847,11676948,11676045,11676140,3233,"33,36",11281077,"32,47",778939,188,149,0.0524927323135,0.156938453279758,"0.023,0.026","0.032,0.038",-0.011]
[3246,"ENSG00000163702.19","IL17RC","chr3","+",9923880,9924137,9923880,9924020,9924231,9924291,3246,"4,10","19,19","4,4","29,17",266,149,0.130680941486,0.325130797526916,"0.105,0.228","0.072,0.116",0.073]
[3262,"ENSG00000180376.16","CCDC66","chr3","+",56563683,56564125,56563683,56563825,56566593,56566759,3262,291239,"0,2",180165,"0,0",298,149,1,1,"1.0,0.984","1.0,1.0",-0.008]
[3277,"ENSG00000137309.19","HMGA1","chr6","+",34240736,34240915,34240736,34240882,34242711,34242795,3277,65786436,29052675,66487194,19292118,182,149,0.000202728126238,0.00128291128356964,"0.65,0.663","0.738,0.736",-0.08]
[3294,"ENSG00000198160.14","MIER1","chr1","+",66984571,66984652,66984571,66984592,66986402,66988619,3294,211231,"44,22",142170,"5,1",209,149,{"v":6.47314413182e-09,"d":"6.47E-09"},{"v":9.41055196893507e-08,"d":"9.41E-08"},"0.774,0.882","0.953,0.992",-0.144]
[3300,"ENSG00000162910.18","MRPL55","chr1","-",228109148,228109299,228109260,228109299,228108954,228109021,3300,188186,"35,30",104121,"22,28",261,149,0.296688375232,0.625620249798269,"0.754,0.78","0.73,0.712",0.046]
[3320,"ENSG00000213963.6","AC019080.1","chr2","-",177323084,177323396,177323303,177323396,177321606,177322237,3320,"67,67","4,5","22,12","0,0",298,149,0.000808294811659,0.00436561622465553,"0.893,0.87","1.0,1.0",-0.119]
[3332,"ENSG00000142794.18","NBPF3","chr1","+",21478143,21478307,21478143,21478196,21479348,21479400,3332,108134,"6,9","50,42","1,0",260,149,0.000992464483935,0.00524922955662376,"0.912,0.895","0.966,1.0",-0.08]
[3338,"ENSG00000010327.10","STAB1","chr3","+",52523426,52523756,52523426,52523576,52523870,52524017,3338,"17,14","0,1","37,33","3,5",298,149,0.00406897737242,0.0179401879395468,"1.0,0.875","0.86,0.767",0.124]
[3352,"ENSG00000186166.8","CCDC84","chr11","+",119011220,119011311,119011220,119011283,119011938,119012003,3352,"47,54","112,74","69,77","28,40",177,149,{"v":1.11867527464E-8,"d":"1.12E-08"},{"v":1.5629491694256E-7,"d":"1.56E-07"},"0.261,0.381","0.675,0.618",-0.326]
[3366,"ENSG00000133422.12","MORC2","chr22","-",30928018,30928207,30928027,30928207,30926610,30926871,3366,227204,"81,72",141195,"79,69",158,149,0.237425857779,0.528169432999686,"0.725,0.728","0.627,0.727",0.049]
[3371,"ENSG00000138674.16","SEC31A","chr4","-",82878729,82878928,82878857,82878928,82875726,82875822,3371,984883,"5,0",694682,"4,2",277,149,1,1,"0.991,1.0","0.989,0.995",0.004]
[3390,"ENSG00000114270.17","COL7A1","chr3","-",48571242,48572045,48572000,48572045,48571100,48571160,3390,"0,3","0,0","9,2","0,2",298,149,1,1,"NA,1.0","1.0,0.333",0.334]
[3398,"ENSG00000169738.7","DCXR","chr17","-",82036190,82036763,82036543,82036763,82035880,82036063,3398,16261788,"0,1",832871,"0,0",298,149,1,1,"1.0,0.999","1.0,1.0",0]
[3416,"ENSG00000143702.15","CEP170","chr1","-",243142285,243142463,243142315,243142463,243139936,243140107,3416,"62,82",341297,"70,32",337268,179,149,0.0734997667139,0.205102111538691,"0.131,0.187","0.147,0.09",0.041]
[3428,"ENSG00000243970.3","PPIEL","chr1","-",39529015,39529164,39529054,39529164,39522279,39522505,3428,"11,9","26,17","11,16","30,23",188,149,0.849958339437,1,"0.251,0.296","0.225,0.355",-0.017]
[3435,"ENSG00000154889.16","MPPE1","chr18","-",11885675,11887025,11886916,11887025,11884878,11885043,3435,"32,61","0,0","38,35","0,1",298,149,1,1,"1.0,1.0","1.0,0.946",0.027]
[3452,"ENSG00000142731.10","PLK4","chr4","+",127892364,127892514,127892364,127892398,127893512,127893604,3452,203194,"5,3",125115,"8,2",265,149,0.160441878128,0.382882370208745,"0.958,0.973","0.898,0.97",0.032]
[3467,"ENSG00000213983.11","AP1G2","chr14","-",23567596,23567783,23567738,23567783,23567110,23567319,3467,"3,9","73,65","29,11","71,35",291,149,{"v":1.00181110899e-05,"d":"1.00E-05"},{"v":8.31595980749569e-05,"d":"8.32E-05"},"0.021,0.066","0.173,0.139",-0.112]
[3483,"ENSG00000112306.7","RPS12","chr6","+",132814971,132815224,132814971,132815088,132816959,132817061,3483,517528,"0,9",11381232,174219,285,149,0,0,"1.0,0.968","0.774,0.746",0.224]
[3491,"ENSG00000116254.17","CHD5","chr1","-",6130147,6130328,6130203,6130328,6128837,6129069,3491,"1,1","48,65","4,7","105,80",205,149,0.0227162816833,0.0785793435205599,"0.015,0.011","0.027,0.06",-0.03]
[3515,"ENSG00000165240.19","ATP7A","chrX","+",77922998,77923052,77922998,77923042,77971620,77971761,3515,"2,0","4,11","0,0","1,0",159,149,1,1,"0.319,0.0","0.0,NA",0.16]
[3531,"ENSG00000204406.13","MBD5","chr2","+",148489385,148490787,148489385,148490594,148502435,148502509,3531,"2,0","15,17","0,1","19,9",298,149,0.625710690991,1,"0.062,0.0","0.0,0.053",0.005]
[3542,"ENSG00000043514.16","TRIT1","chr1","-",39850118,39850261,39850122,39850261,39847985,39848097,3542,172177,"37,43","114,93","16,9",153,149,0.00824138880297,0.0330085110731017,"0.819,0.8","0.874,0.91",-0.083]
[3560,"ENSG00000088035.16","ALG6","chr1","+",63411145,63411331,63411145,63411155,63411925,63412061,3560,308306,"4,10",287302,"29,12",298,149,0.000325586986017,0.00195461205109982,"0.975,0.939","0.832,0.926",0.078]
[3563,"ENSG00000165233.17","CARD19","chr9","+",93107673,93107827,93107673,93107816,93108990,93109092,3563,"4,5","1,0","3,6","0,0",160,149,1,1,"0.788,1.0","1.0,1.0",-0.106]
[3580,"ENSG00000007923.15","DNAJC11","chr1","-",6638082,6638364,6638294,6638364,6637446,6637504,3580,"70,83",1070874,66112,771771,298,149,0.0157611584244,0.0580282485727909,"0.032,0.045","0.041,0.068",-0.016]
[3596,"ENSG00000162585.16","FAAP20","chr1","-",2198753,2201225,2201049,2201225,2198006,2198142,3596,"13,16","1,2","30,21","0,0",298,149,0.144583724713,0.351589446307064,"0.867,0.8","1.0,1.0",-0.166]
[3605,"ENSG00000197386.12","HTT","chr4","+",3172907,3173331,3172907,3173131,3174720,3174799,3605,"9,11",180147,"23,27","119,87",298,149,{"v":7.48394238581e-07,"d":"7.48E-07"},{"v":7.83193114655096e-06,"d":"7.83E-06"},"0.024,0.036","0.088,0.134",-0.081]
[3619,"ENSG00000011021.22","CLCN6","chr1","+",11826155,11826224,11826155,11826214,11827088,11827221,3619,"3,1","87,71","5,7","32,43",159,149,0.000459487301294,2.67198074990316E-3,"0.031,0.013","0.128,0.132",-0.108]
[3632,"ENSG00000116857.16","TMEM9","chr1","-",201153782,201153959,201153857,201153959,201151760,201151852,3632,"2,2",915964,"12,14",11301211,224,149,1,1,"0.001,0.001","0.007,0.008",-0.006]
[3638,"ENSG00000021776.10","AQR","chr15","-",34906518,34906712,34906544,34906712,34904335,34904505,3638,"1,4",434405,"9,16",413338,175,149,0.000634105167448,3.53822790010663E-3,"0.002,0.008","0.018,0.039",-0.023]
[3655,"ENSG00000138386.16","NAB1","chr2","+",190655976,190656159,190655976,190656153,190659157,190659995,3655,"11,2",102102,"2,6","93,85",155,149,0.398641092128,0.774671399767526,"0.094,0.019","0.02,0.064",0.014]
[3671,"ENSG00000031823.14","RANBP3","chr19","-",5957906,5957973,5957917,5957973,5933413,5933479,3671,"0,0","6,5","1,0","12,11",160,149,1,1,"0.0,0.0","0.072,0.0",-0.036]
[3678,"ENSG00000104852.14","SNRNP70","chr19","+",49102113,49103587,49102113,49102173,49104633,49104735,3678,9171210,117103,18471974,106158,298,149,0.00259611903356,0.0121452225053262,"0.797,0.855","0.897,0.862",-0.053]
[3688,"ENSG00000090013.10","BLVRB","chr19","-",40457498,40458244,40458173,40458244,40451363,40451492,3688,128169,"41,24",147132,"30,40",298,149,0.618793201559,1,"0.61,0.779","0.71,0.623",0.028]
[3700,"ENSG00000109762.15","SNX25","chr4","+",185332594,185332759,185332594,185332713,185339378,185339510,3700,"67,50","8,0","20,6","7,4",195,149,0.000892986600824,0.00475581675824979,"0.865,1.0","0.686,0.534",0.322]
[3718,"ENSG00000168264.10","IRF2BP2","chr1","-",234608446,234609525,234608494,234609525,234604268,234607852,3718,532556,696648,705815,405398,197,149,{"v":3.19411164185e-13,"d":"3.19E-13"},{"v":7.63605623178273e-12,"d":"7.64E-12"},"0.366,0.394","0.568,0.608",-0.208]
[3741,"ENSG00000181555.20","SETD2","chr3","-",47080800,47081083,47080915,47081083,47067069,47067118,3741,"38,40","12,16","15,23","3,4",264,149,0.0940840938198,0.249299675200346,"0.641,0.585","0.738,0.764",-0.138]
[3744,"ENSG00000178999.12","AURKB","chr17","-",8207175,8207367,8207317,8207367,8206749,8206888,3744,955882,"19,18",654659,"10,9",291,149,0.220023913359,0.49643818370724,"0.963,0.962","0.971,0.974",-0.01]
[3766,"ENSG00000249859.9","PVT1","chr8","+",128070159,128070361,128070159,128070272,128082752,128082848,3766,"33,32","1,1","12,16","0,0",238,149,0.375263018078,0.742110211118221,"0.954,0.952","1.0,1.0",-0.047]
[3777,"ENSG00000126088.13","UROD","chr1","+",45013135,45013354,45013135,45013215,45013593,45013791,3777,35643778,"55,72",17361901,"25,18",288,149,0.0460254939469,0.140665415875213,"0.971,0.964","0.973,0.982",-0.01]
[3788,"ENSG00000003509.15","NDUFAF7","chr2","+",37241577,37241791,37241577,37241637,37243862,37243973,3788,180192,"14,14",115197,"78,51",298,149,{"v":3.25420886349e-07,"d":"3.25E-07"},{"v":3.62409720014755e-06,"d":"3.62E-06"},"0.865,0.873","0.424,0.659",0.328]
[3802,"ENSG00000241370.5","RPP21","chr6","+",30345297,30345573,30345297,30345398,30346431,30346557,3802,506564,"5,12",444476,58119,298,149,0,0,"0.981,0.959","0.793,0.667",0.24]
[3824,"ENSG00000114861.20","FOXP1","chr3","-",70977642,70977719,70977646,70977719,70976940,70977042,3824,"102,90","1,4",137112,"7,4",153,149,0.211363072386,0.479276080711123,"0.99,0.956","0.95,0.965",0.015]
[3848,"ENSG00000125877.12","ITPA","chr20","+",3213318,3213426,3213318,3213383,3213984,3214058,3848,"13,6",19891838,"28,11",13611339,192,149,0.620270811692,1,"0.005,0.003","0.016,0.006",-0.007]
[3857,"ENSG00000126091.20","ST3GAL3","chr1","+",43814890,43815004,43814890,43814933,43838218,43838311,3857,"2,4",176175,"1,1","54,81",220,149,1,1,"0.008,0.015","0.012,0.008",1E-3]
[3868,"ENSG00000205726.14","ITSN1","chr21","+",33829005,33829168,33829005,33829050,33829623,33829745,3868,"1,9","5,0","4,6","0,0",267,149,0.00457382884046,0.0198088770795767,"0.1,1.0","1.0,1.0",-0.45]
[3879,"ENSG00000086189.9","DIMT1","chr5","-",62398428,62398560,62398510,62398560,62394483,62394607,3879,"10,7",405387,"11,9","65,53",231,149,{"v":7.87448481976e-08,"d":"7.87E-08"},{"v":9.6265576921566e-07,"d":"9.63E-07"},"0.016,0.012","0.098,0.099",-0.085]
[3885,"ENSG00000116353.15","MECR","chr1","-",29220833,29220921,29220837,29220921,29216587,29216812,3885,"5,8","23,11","0,0","3,2",153,149,0.00012226464007,0.000817844432728878,"0.175,0.415","0.0,0.0",0.295]
[3896,"ENSG00000132781.17","MUTYH","chr1","-",45338185,45338656,45338506,45338656,45334390,45334511,3896,"63,67","31,11",150116,"1,3",298,149,{"v":4.83873718871e-10,"d":"4.84E-10"},{"v":8.34216901861253e-09,"d":"8.34E-09"},"0.504,0.753","0.987,0.951",-0.34]
[3906,"ENSG00000108523.15","RNF167","chr17","+",4940486,4940993,4940486,4940726,4941076,4941157,3906,593593,"3,3",580635,"4,13",298,149,0.0205174701849,0.0723694899177554,"0.99,0.99","0.986,0.961",0.016]
[3924,"ENSG00000159069.13","FBXW5","chr9","-",136942045,136942695,136942546,136942695,136941536,136941684,3924,599720,"0,0",260305,"2,0",298,149,1,1,"1.0,1.0","0.985,1.0",0.008]
[3940,"ENSG00000127483.17","HP1BP3","chr1","-",20780344,20780540,20780349,20780540,20779811,20779911,3940,1058965,102115,920815,"61,31",154,149,{"v":7.18191295157e-06,"d":"7.18E-06"},{"v":6.16132532161005e-05,"d":"6.16E-05"},"0.909,0.89","0.936,0.962",-0.05]
[3945,"ENSG00000204209.12","DAXX","chr6","-",33318996,33319219,33319201,33319219,33318558,33318802,3945,13241230,"0,1",800930,"0,0",298,149,1,1,"1.0,0.998","1.0,1.0",-1E-3]
[3959,"ENSG00000153140.8","CETN3","chr5","-",90405684,90405799,90405688,90405799,90399357,90399549,3959,507453,"1,0",394430,"2,3",153,149,1,1,"0.998,1.0","0.995,0.993",0.005]
[3978,"ENSG00000139631.18","CSAD","chr12","-",53171272,53171441,53171325,53171441,53170422,53170502,3978,"18,17","25,24","14,5","11,6",202,149,0.3194847533,0.660964803077192,"0.347,0.343","0.484,0.381",-0.088]
[3983,"ENSG00000143390.17","RFX5","chr1","-",151346421,151346606,151346481,151346606,151346204,151346333,3983,"9,4","76,46","6,3","37,45",209,149,0.948291566974,1,"0.078,0.058","0.104,0.045",-0.006]
[4009,"ENSG00000060656.19","PTPRU","chr1","+",29311455,29311553,29311455,29311544,29311642,29311759,4009,"23,17","18,5","13,15","9,18",158,149,0.208988826881,0.474725886736866,"0.546,0.762","0.577,0.44",0.146]
[4026,"ENSG00000118513.18","MYB","chr6","+",135195747,135196002,135195747,135195917,135196960,135197323,4026,975931,"2,0",17411788,"3,7",234,149,1,1,"0.997,1.0","0.997,0.994",0.003]
[4038,"ENSG00000213316.9","LTC4S","chr5","+",179795583,179795856,179795583,179795683,179795940,179796022,4038,619716,"6,16",9281131,"14,15",298,149,0.700832404367,1,"0.981,0.957","0.971,0.974",-0.003]
[4054,"ENSG00000117448.13","AKR1A1","chr1","+",45568926,45569006,45568926,45568999,45569142,45569229,4054,"3,0",12391220,"2,1",424423,156,149,1,1,"0.002,0.0","0.004,0.002",-2E-3]
[4069,"ENSG00000197622.12","CDC42SE1","chr1","-",151055015,151055993,151055676,151055993,151054230,151054321,4069,985825,"11,3",794886,"39,19",298,149,{"v":6.67228565732e-08,"d":"6.67E-08"},{"v":8.25062633349983e-07,"d":"8.25E-07"},"0.978,0.993","0.911,0.959",0.05]
[4070,"ENSG00000197622.12","CDC42SE1","chr1","-",151056650,151056786,151056655,151056786,151055676,151055993,4070,"63,32","20,20","8,13","0,1",154,149,{"v":2.81405773856e-05,"d":"2.81E-05"},0.000218424481612038,"0.753,0.608","1.0,0.926",-0.283]
[4098,"ENSG00000169598.15","DFFB","chr1","+",3858717,3858866,3858717,3858844,3865811,3866000,4098,"3,6","61,76","21,18","69,84",171,149,{"v":7.77292259054e-05,"d":"7.77E-05"},0.000543519155485088,"0.041,0.064","0.21,0.157",-0.131]
[4105,"ENSG00000172053.17","QARS","chr3","-",49104323,49104420,49104372,49104420,49103862,49103972,4105,27782903,"40,19",15061555,"9,6",198,149,0.117523122425,0.298892139727695,"0.981,0.991","0.992,0.995",-0.008]
[4119,"ENSG00000198198.16","SZT2","chr1","+",43432988,43434485,43432988,43433190,43435199,43435329,4119,134166,"0,0",145141,"11,9",298,149,{"v":9.47451170852e-08,"d":"9.47E-08"},{"v":1.14524490966582E-6,"d":"1.15E-06"},"1.0,1.0","0.868,0.887",0.123]
[4130,"ENSG00000114388.12","NPRL2","chr3","-",50349664,50350022,50349912,50350022,50349385,50349494,4130,225198,"1,0","97,91","0,0",298,149,1,1,"0.991,1.0","1.0,1.0",-0.004]
[4140,"ENSG00000125703.14","ATG4C","chr1","+",62784134,62784273,62784134,62784225,62803777,62803862,4140,"5,9","0,1","4,6","0,0",197,149,1,1,"1.0,0.872","1.0,1.0",-0.064]
[4158,"ENSG00000244005.12","NFS1","chr20","-",35699191,35699352,35699309,35699352,35698480,35698590,4158,154223,"11,15",213215,"11,8",267,149,0.163663694477,0.389361792389112,"0.887,0.892","0.915,0.937",-0.037]
[4171,"ENSG00000163374.19","YY1AP1","chr1","-",155680381,155680456,155680415,155680456,155679408,155679512,4171,"10,12",395431,"6,5",319385,183,149,0.121173426693,0.306149301165639,"0.02,0.022","0.015,0.01",0.008]
[4178,"ENSG00000112787.13","FBRSL1","chr12","+",132572287,132572344,132572287,132572338,132572526,132572622,4178,559582,"78,73",300308,"41,37",155,149,0.820386042255,1,"0.873,0.885","0.876,0.889",-0.004]
[4192,"ENSG00000144357.16","UBR3","chr2","+",170006989,170007202,170006989,170007190,170008803,170008940,4192,"58,66","107,97",171140,273239,161,149,0.995304888393,1,"0.334,0.386","0.367,0.352",1E-3]
[4201,"ENSG00000163608.14","NEPRO","chr3","-",113013948,113014032,113013952,113014032,113011044,113011406,4201,"2,8","5,3","0,0","0,1",153,149,1,1,"0.28,0.722","NA,0.0",0.501]
[4225,"ENSG00000135912.10","TTLL4","chr2","+",218752762,218752973,218752762,218752847,218753583,218753669,4225,147227,"0,0","94,88","5,2",275,149,4.02900881758E-3,0.0177931349998052,"1.0,1.0","0.911,0.96",0.065]
[4228,"ENSG00000172671.19","ZFAND4","chr10","-",45672271,45672762,45672678,45672762,45663541,45663842,4228,120117,"4,11",178188,"10,16",298,149,0.649956079692,1,"0.938,0.842","0.899,0.855",0.013]
[4246,"ENSG00000283235.1","AC139493.2","chr5","-",176182619,176182763,176182684,176182763,176180815,176180886,4246,"23,9","46,37","78,63","11,7",214,149,0,0,"0.258,0.145","0.832,0.862",-0.645]
[4252,"ENSG00000106603.18","COA1","chr7","-",43650492,43650712,43650611,43650712,43648599,43648652,4252,"48,41","51,93","29,26","7,14",268,149,1.9124501227E-4,1.21740464023707E-3,"0.344,0.197","0.697,0.508",-0.332]
[4268,"ENSG00000172009.14","THOP1","chr19","+",2807441,2807808,2807441,2807773,2808242,2808444,4268,499548,"0,0",277308,"8,4",184,149,0.0484572154427,0.146598066291497,"1.0,1.0","0.966,0.984",0.025]
[4279,"ENSG00000177302.14","TOP3A","chr17","-",18290539,18290686,18290556,18290686,18285406,18285520,4279,"3,1",247291,"0,6","50,51",166,149,0.0431073973644,0.133645354710724,"0.011,0.003","0.0,0.096",-0.041]
[4292,"ENSG00000196655.11","TRAPPC4","chr11","+",119018765,119019317,119018765,119018970,119020149,119020253,4292,867813,"1,4",142200,"0,0",298,149,1,1,"0.998,0.99","1.0,1.0",-0.006]
[4309,"ENSG00000115760.14","BIRC6","chr2","+",32471013,32471151,32471013,32471124,32473111,32473239,4309,221229,"47,46",216239,"32,34",176,149,0.0729692853475,0.204234517789125,"0.799,0.808","0.851,0.856",-0.05]
[4339,"ENSG00000127586.16","CHTF18","chr16","+",788623,788775,788623,788756,788930,789125,4339,461515,"40,32",211195,"23,24",168,149,0.0532204703586,0.158687865886313,"0.911,0.935","0.891,0.878",0.038]
[4344,"ENSG00000130511.15","SSBP4","chr19","+",18432558,18432735,18432558,18432604,18432828,18432883,4344,10281101,"0,0",754885,"11,9",280,149,0.0114622065735,0.0439452666848585,"1.0,1.0","0.973,0.981",0.023]
[4365,"ENSG00000169247.12","SH3TC2","chr5","-",149041415,149041617,149041473,149041617,149040603,149040677,4365,"3,5","3,4","31,31","3,2",207,149,5.23947785107E-4,0.00299184197037213,"0.419,0.474","0.881,0.918",-0.453]
[4371,"ENSG00000141577.13","CEP131","chr17","-",81198105,81198297,81198114,81198297,81197711,81197888,4371,"17,28","58,67","13,32","55,32",158,149,0.430669873689,0.817133421718917,"0.217,0.283","0.182,0.485",-0.084]
[4385,"ENSG00000197530.12","MIB2","chr1","+",1625545,1626754,1625545,1625653,1626836,1626999,4385,"80,86","4,2","85,92","0,0",298,149,0.0108599239307,0.0419651801891058,"0.909,0.956","1.0,1.0",-0.068]
[4400,"ENSG00000214021.15","TTLL3","chr3","+",9833103,9833273,9833103,9833245,9834426,9834503,4400,"16,27","4,1","9,12","0,0",177,149,0.00783826507312,0.0317007728032424,"0.771,0.958","1.0,1.0",-0.135]
[4419,"ENSG00000196365.11","LONP1","chr19","-",5711770,5712002,5711818,5712002,5708341,5708403,4419,10021166,"0,1",593665,"2,1",197,149,1,1,"1.0,0.999","0.996,0.998",0.003]
[4423,"ENSG00000122218.15","COPA","chr1","-",160306353,160306493,160306454,160306493,160305687,160305773,4423,867972,"8,9",366321,"2,6",250,149,0.894535186428,1,"0.985,0.985","0.991,0.97",0.005]
[4436,"ENSG00000224078.13","SNHG14","chr15","+",25099144,25102147,25099144,25099278,25103858,25103970,4436,"1,3","74,88","1,0","36,34",298,149,1,1,"0.007,0.017","0.014,0.0",0.005]
[4444,"ENSG00000197062.11","ZSCAN26","chr6","+",28271853,28272336,28271853,28271934,28272669,28272787,4444,"22,15","82,63","105,96","36,37",298,149,0,0,"0.118,0.106","0.593,0.565",-0.467]
[4452,"ENSG00000119760.15","SUPT7L","chr2","-",27660983,27662281,27662178,27662281,27655364,27655602,4452,103142,"0,1",93126,"0,0",298,149,1,1,"1.0,0.986","1.0,1.0",-0.007]
[4472,"ENSG00000196975.15","ANXA4","chr2","+",69810593,69811456,69810593,69810673,69812652,69812709,4472,"6,2",183147,"0,0","20,27",298,149,0.84385875928,1,"0.016,0.007","0.0,0.0",0.011]
[4481,"ENSG00000179818.13","PCBP1-AS1","chr2","-",70083506,70083687,70083537,70083687,70077300,70077381,4481,"18,16","0,2","5,7","0,1",180,149,0.715518836689,1,"1.0,0.869","1.0,0.853",0.008]
[4502,"ENSG00000163029.15","SMC6","chr2","-",17752977,17753064,17753001,17753064,17745826,17745951,4502,"86,79","5,2","3,17","1,0",173,149,0.113239648087,0.290055270028558,"0.937,0.971","0.721,1.0",0.093]
[4519,"ENSG00000228486.10","C2orf92","chr2","+",97671330,97671574,97671330,97671499,97675630,97675721,4519,"3,16","0,1","4,4","0,0",224,149,1,1,"1.0,0.914","1.0,1.0",-0.043]
[4526,"ENSG00000084090.13","STARD7","chr2","-",96193241,96193352,96193301,96193352,96193077,96193160,4526,20251908,"4,7",17471966,"4,1",209,149,1,1,"0.997,0.995","0.997,0.999",-2E-3]
[4539,"ENSG00000213672.7","NCKIPSD","chr3","-",48682868,48683012,48682902,48683012,48682347,48682552,4539,"2,6",112163,"5,6","91,84",183,149,0.11026819898,0.283795522638,"0.014,0.029","0.043,0.055",-0.028]
[4553,"ENSG00000134910.13","STT3A","chr11","+",125608108,125608289,125608108,125608243,125612591,125612747,4553,880905,"0,0",355369,"0,1",195,149,1,1,"1.0,1.0","1.0,0.996",2E-3]
[4579,"ENSG00000124155.17","PIGT","chr20","+",45416516,45416694,45416516,45416654,45418851,45418979,4579,500437,"2,2",251301,"0,0",189,149,1,1,"0.995,0.994","1.0,1.0",-0.006]
[4584,"ENSG00000124155.17","PIGT","chr20","+",45416516,45418979,45416516,45416694,45420135,45420223,4584,"4,10","0,0","24,20","1,3",298,149,0.0169081122381,0.0616601598160948,"1.0,1.0","0.923,0.769",0.154]
[4599,"ENSG00000082996.19","RNF13","chr3","+",149895472,149895570,149895472,149895560,149911977,149912083,4599,"5,9","0,4","28,11","13,20",159,149,0.042333426299,0.131777488461991,"1.0,0.678","0.669,0.34",0.334]
[4600,"ENSG00000082996.19","RNF13","chr3","+",149895472,149895570,149895472,149895560,149921133,149921227,4600,"1,1","0,0","17,20","7,1",159,149,0.000715541308768,0.0039114803860397,"1.0,1.0","0.695,0.949",0.178]
[4622,"ENSG00000254505.9","CHMP4A","chr14","-",24211410,24211592,24211414,24211592,24210347,24210483,4622,"2,1","2,0","1,0","1,0",153,149,1,1,"0.493,1.0","0.493,NA",0.253]
[4624,"ENSG00000130414.11","NDUFA10","chr2","-",240011616,240014860,240014738,240014860,239960740,239961186,4624,181169,"1,0",50109,"0,0",298,149,1,1,"0.989,1.0","1.0,1.0",-0.006]
[4653,"ENSG00000165699.14","TSC1","chr9","-",132901588,132901699,132901630,132901699,132900714,132900837,4653,"95,79","4,4",132150,"1,1",191,149,0.00811067448919,0.032582014994289,"0.949,0.939","0.99,0.992",-0.047]
[4664,"ENSG00000115685.14","PPP1R7","chr2","+",241158483,241158549,241158483,241158531,241163284,241163401,4664,"66,39","0,1","48,51","1,0",167,149,1,1,"1.0,0.972","0.977,1.0",-2E-3]
[4671,"ENSG00000163138.18","PACRGL","chr4","+",20700457,20700747,20700457,20700611,20704465,20704533,4671,"75,83","6,4",102139,"5,9",285,149,0.928020687057,1,"0.867,0.916","0.914,0.89",-0.011]
[4685,"ENSG00000283189.2","AC104452.1","chr3","-",49420210,49420342,49420214,49420342,49419709,49419788,4685,"11,6","1,0","17,36","0,0",153,149,1,1,"0.915,1.0","1.0,1.0",-0.042]
[4701,"ENSG00000172965.15","MIR4435-2HG","chr2","-",111365560,111367575,111367486,111367575,111350607,111350761,4701,259256,"0,0",357315,"1,0",298,149,1,1,"1.0,1.0","0.994,1.0",0.003]
[4714,"ENSG00000184470.20","TXNRD2","chr22","-",19877039,19877234,19877108,19877234,19875521,19875807,4714,"24,31","3,0","12,27","0,0",218,149,0.387743834934,0.758978925804216,"0.845,1.0","1.0,1.0",-0.078]
[4729,"ENSG00000182093.15","WRB","chr21","+",39390697,39391476,39390697,39390919,39391768,39391836,4729,"50,28","3,3",97115,"7,8",298,149,0.855434907852,1,"0.893,0.824","0.874,0.878",-0.017]
[4737,"ENSG00000129187.14","DCTD","chr4","-",182916285,182916539,182916418,182916539,182915880,182915888,4737,"88,64","18,19",114102,"20,9",282,149,0.0440016430109,0.135558326320521,"0.721,0.64","0.751,0.857",-0.124]
[4765,"ENSG00000161939.19","RNASEK-C17orf49","chr17","+",7014144,7014878,7014144,7014277,7015061,7015156,4765,15651611,"3,3",16202044,"12,11",298,149,0.643898427561,1,"0.996,0.996","0.985,0.989",0.009]
[4777,"ENSG00000164039.14","BDH2","chr4","-",103085348,103086540,103086479,103086540,103082870,103082929,4777,210144,"38,18",132128,"99,77",298,149,{"v":4.52970994047E-14,"d":"4.53E-14"},{"v":1.22438742561749E-12,"d":"1.22E-12"},"0.734,0.8","0.4,0.454",0.34]
[4786,"ENSG00000135838.13","NPL","chr1","+",182806144,182806531,182806144,182806232,182812155,182812213,4786,124121,213135,125191,"53,53",298,149,{"v":1.84308124318e-12,"d":"1.84E-12"},{"v":4.14808954270511e-11,"d":"4.15E-11"},"0.225,0.309","0.541,0.643",-0.325]
[4798,"ENSG00000214530.9","STARD10","chr11","-",72781061,72781294,72781112,72781294,72759233,72759381,4798,"28,17","0,0","26,11","0,3",200,149,0.221427618036,0.499395873130249,"1.0,1.0","1.0,0.732",0.134]
[4822,"ENSG00000105193.8","RPS16","chr19","-",39433521,39433761,39433664,39433761,39433206,39433418,4822,3323631841,"12,9",3144735247,"13,9",292,149,1,1,"0.999,0.999","0.999,0.999",0]
[4842,"ENSG00000109220.10","CHIC2","chr4","-",54048954,54049110,54049038,54049110,54014062,54014119,4842,271287,"16,13",264301,"11,6",233,149,0.0769255382148,0.212413999002776,"0.915,0.934","0.939,0.97",-0.03]
[4868,"ENSG00000105771.13","SMG9","chr19","-",43739672,43740218,43740106,43740218,43738121,43738217,4868,"4,5",454385,"23,26",373372,298,149,{"v":4.44730368976e-07,"d":"4.45E-07"},{"v":4.892034058736e-06,"d":"4.89E-06"},"0.004,0.006","0.03,0.034",-0.027]
[4874,"ENSG00000128694.11","OSGEPL1","chr2","-",189761419,189761660,189761646,189761660,189755172,189755560,4874,214212,"0,5",193217,"0,8",298,149,0.371806869708,0.737444377639871,"1.0,0.955","1.0,0.931",0.012]
[4894,"ENSG00000100359.20","SGSM3","chr22","+",40407016,40407568,40407016,40407328,40408070,40408120,4894,"43,47","0,0",118112,"0,4",298,149,0.660020954449,1,"1.0,1.0","1.0,0.933",0.033]
[4899,"ENSG00000104432.13","IL7","chr8","-",78798071,78798208,78798127,78798208,78721347,78721440,4899,"29,33","0,2","17,17","0,0",205,149,0.411619332268,0.793868909383138,"1.0,0.923","1.0,1.0",-0.038]
[4907,"ENSG00000082153.17","BZW1","chr2","+",200811545,200811990,200811545,200811727,200813207,200813281,4907,13931342,184206,12811379,268205,298,149,0.0834075845021,0.227049289998378,"0.791,0.765","0.705,0.771",0.04]
[4932,"ENSG00000112031.15","MTRF1L","chr6","-",152995135,152995319,152995243,152995319,152994512,152994676,4932,357274,"36,45",342379,"20,21",257,149,1.79856380313E-4,0.00115035370951679,"0.852,0.779","0.908,0.913",-0.095]
[4946,"ENSG00000163481.7","RNF25","chr2","-",218668238,218668341,218668278,218668341,218668078,218668146,4946,293205,"5,11",216243,"11,3",189,149,0.894250199429,1,"0.979,0.936","0.939,0.985",-0.004]
[4956,"ENSG00000140043.11","PTGR2","chr14","+",73874022,73874214,73874022,73874143,73876997,73877168,4956,197163,"0,0",218241,"2,0",220,149,1,1,"1.0,1.0","0.987,1.0",0.006]
[4975,"ENSG00000127415.12","IDUA","chr4","+",987808,987949,987808,987911,1000611,1000697,4975,140144,"1,6","92,99","1,2",187,149,0.309749440688,0.647548480940828,"0.991,0.95","0.987,0.975",-0.011]
[4977,"ENSG00000100650.15","SRSF5","chr14","+",69767092,69767380,69767092,69767255,69768137,69768282,4977,373340,858992,555565,928980,274,149,0.000281811955332,1.71478111734256E-3,"0.191,0.157","0.245,0.239",-0.068]
[4999,"ENSG00000284770.1","TBCE","chr1","+",235367412,235367552,235367412,235367504,235380018,235380149,4999,"9,3",116143,"8,17",111140,197,149,0.0263161516901,0.0890840654128684,"0.055,0.016","0.052,0.084",-0.033]
[5000,"ENSG00000284770.1","TBCE","chr1","+",235414432,235414618,235414432,235414469,235419416,235419561,5000,544444,"3,0",333409,"0,1",298,149,1,1,"0.989,1.0","1.0,0.995",-0.003]
[5011,"ENSG00000284770.1","TBCE","chr1","+",235442851,235442961,235442851,235442911,235448348,235448440,5011,"7,10",673529,"13,13",406336,199,149,0.00606567048942,0.0252924353198373,"0.008,0.014","0.023,0.028",-0.015]
[5033,"ENSG00000115677.16","HDLBP","chr2","-",241268953,241269295,241269200,241269295,241268476,241268541,5033,"33,41","6,3","24,30","2,1",298,149,0.11946857793,0.302552486198432,"0.733,0.872","0.857,0.938",-0.095]
[5040,"ENSG00000166411.13","IDH3A","chr15","+",78155212,78155275,78155212,78155251,78157547,78157631,5040,302229,"16,2",152138,"0,0",173,149,0.000808357270823,0.00436561622465553,"0.942,0.99","1.0,1.0",-0.034]
[5053,"ENSG00000163719.19","MTMR14","chr3","+",9653620,9653873,9653620,9653769,9662266,9662375,5053,"2,10",380372,"18,14",360400,253,149,0.00417531840232,0.0183189540669488,"0.003,0.016","0.029,0.02",-0.015]
[5070,"ENSG00000234684.6","SDCBP2-AS1","chr20","+",1325420,1325782,1325420,1325529,1373077,1373178,5070,"12,6","2,2","27,8","6,6",298,149,0.342872121577,0.69521825980134,"0.75,0.6","0.692,0.4",0.129]
[5085,"ENSG00000137185.12","ZSCAN9","chr6","+",28225291,28225366,28225291,28225330,28227011,28227504,5085,"42,21","13,19","48,48","16,8",185,149,0.0795664513975,0.21836119493222,"0.722,0.471","0.707,0.829",-0.171]
[5100,"ENSG00000136404.15","TM6SF1","chr15","+",83119577,83119734,83119577,83119681,83121920,83122003,5100,"24,9","37,46","31,11","17,9",202,149,0.000330197824508,0.0019800826064978,"0.324,0.126","0.574,0.474",-0.299]
[5112,"ENSG00000126249.7","PDCD2L","chr19","+",34404648,34404990,34404648,34404815,34413736,34413847,5112,"11,12","0,1","13,28","0,0",298,149,1,1,"1.0,0.857","1.0,1.0",-0.072]
[5115,"ENSG00000157224.15","CLDN12","chr7","+",90405518,90405612,90405518,90405608,90412643,90415954,5115,"1,3","35,28","6,8","9,25",153,149,0.00042629023918,0.00250329169928954,"0.027,0.094","0.394,0.238",-0.256]
[5133,"ENSG00000119778.14","ATAD2B","chr2","-",23786026,23786223,23786041,23786223,23782868,23783028,5133,"63,94","17,32",96100,"30,37",164,149,0.672601682825,1,"0.771,0.727","0.744,0.711",0.021]
[5140,"ENSG00000177463.15","NR2C2","chr3","+",15037999,15039227,15037999,15038137,15042833,15043349,5140,154163,"0,0",218190,"0,4",298,149,0.547267931933,0.96264035509078,"1.0,1.0","1.0,0.96",0.02]
[5151,"ENSG00000172046.18","USP19","chr3","-",49116726,49116943,49116733,49116943,49116450,49116607,5151,331311,"0,0",95108,"0,1",156,149,1,1,"1.0,1.0","1.0,0.99",0.005]
[5173,"ENSG00000136247.14","ZDHHC4","chr7","+",6578565,6578746,6578565,6578720,6580554,6580678,5173,"33,25",294253,"29,42",217222,175,149,0.0470640660528,0.142961601066941,"0.087,0.078","0.102,0.139",-0.038]
[5187,"ENSG00000145868.16","FBXO38","chr5","+",148427212,148427947,148427212,148427722,148433423,148433524,5187,127112,"19,16",221251,"17,19",298,149,0.0173141183061,0.0627578452618004,"0.77,0.778","0.867,0.869",-0.094]
[5209,"ENSG00000132406.11","TMEM128","chr4","-",4247600,4248212,4248105,4248212,4246201,4246343,5209,"58,43",91118,106100,116135,298,149,0.00582322643578,0.0244038743391007,"0.242,0.154","0.314,0.27",-0.094]
[5212,"ENSG00000136273.12","HUS1","chr7","-",47979409,47979553,47979467,47979553,47978688,47978816,5212,"10,17","109,87","26,30",186166,207,149,0.521077955514,0.929644551479206,"0.062,0.123","0.091,0.115",-0.011]
[5223,"ENSG00000100029.17","PES1","chr22","-",30584364,30584454,30584415,30584454,30581527,30581644,5223,16421638,"13,17",13191521,"11,5",200,149,0.612647582821,1,"0.989,0.986","0.989,0.996",-0.005]
[5236,"ENSG00000136270.13","TBRG4","chr7","-",45102280,45102491,45102346,45102491,45101824,45102070,5236,"9,10",348383,"2,1",326314,215,149,0.103966621531,0.27078815666076,"0.018,0.018","0.004,0.002",0.015]
[5249,"ENSG00000132436.11","FIGNL1","chr7","-",50449499,50449723,50449562,50449723,50448180,50448289,5249,"32,28","32,29","4,4","0,1",212,149,0.000153616002144,1.00279183923856E-3,"0.413,0.404","1.0,0.738",-0.461]
[5270,"ENSG00000109445.10","ZNF330","chr4","+",141220929,141221077,141220929,141221016,141224486,141224506,5270,"122,61","0,0",92111,"4,1",210,149,0.305413794096,0.640975730956841,"1.0,1.0","0.942,0.987",0.036]
[5284,"ENSG00000039523.19","RIPOR1","chr16","+",67540457,67540704,67540457,67540501,67541429,67541578,5284,187174,"1,0",200206,"1,1",298,149,1,1,"0.989,1.0","0.99,0.99",0.004]
[5292,"ENSG00000071462.11","BUD23","chr7","+",73683766,73683923,73683766,73683901,73686635,73686731,5292,"3,3","21,17","1,13","15,27",171,149,0.274003181582,0.590490029539093,"0.111,0.133","0.055,0.296",-0.053]
[5309,"ENSG00000127452.8","FBXL12","chr19","-",9818727,9819079,9818753,9819079,9818544,9818617,5309,181141,"32,48",108138,"83,38",175,149,0.0550161338173,0.162778758967687,"0.828,0.714","0.526,0.756",0.13]
[5320,"ENSG00000092208.17","GEMIN2","chr14","+",39114305,39114475,39114305,39114395,39117998,39118088,5320,"48,33","0,0","31,41","0,1",229,149,1,1,"1.0,1.0","1.0,0.964",0.018]
[5330,"ENSG00000008277.14","ADAM22","chr7","+",88178934,88179129,88178934,88179042,88181504,88181605,5330,"2,7","5,0","5,0","0,0",236,149,1,1,"0.202,1.0","1.0,NA",-0.399]
[5339,"ENSG00000130948.10","HSD17B3","chr9","-",96244290,96244394,96244328,96244394,96240757,96240907,5339,"0,3","39,61","4,3","11,10",187,149,0.000676872396441,0.00374192869522727,"0.0,0.038","0.225,0.193",-0.19]
[5357,"ENSG00000196367.13","TRRAP","chr7","+",98983263,98983492,98983263,98983459,98984092,98984358,5357,135125,156180,"124,92",102120,182,149,0.245702639708,0.541209868546,"0.415,0.362","0.499,0.386",-0.054]
[5375,"ENSG00000221838.9","AP4M1","chr7","+",100101879,100102393,100101879,100101989,100102674,100102781,5375,"21,16","1,3","25,29","1,2",298,149,0.573581891618,0.989472881408564,"0.913,0.727","0.926,0.879",-0.083]
[5386,"ENSG00000106327.12","TFR2","chr7","-",100627263,100627661,100627576,100627661,100620419,100621126,5386,231211,"3,1",441502,"2,2",298,149,0.552741136198,0.967836774612318,"0.975,0.991","0.991,0.992",-0.009]
[5404,"ENSG00000105821.14","DNAJC2","chr7","-",103322510,103322794,103322702,103322794,103319608,103319678,5404,156120,"4,0",195166,"3,0",298,149,0.47362899291,0.866253095159092,"0.951,1.0","0.97,1.0",-0.009]
[5416,"ENSG00000149100.12","EIF3M","chr11","+",32593865,32595013,32593865,32593949,32595965,32596047,5416,24732471,"5,0",18561787,"53,46",298,149,0,0,"0.996,1.0","0.946,0.951",0.05]
[5427,"ENSG00000135241.16","PNPLA8","chr7","-",108487758,108487953,108487944,108487953,108479183,108479379,5427,"113,91","10,3",123154,"2,14",298,149,0.785325193038,1,"0.85,0.938","0.969,0.846",-0.014]
[5437,"ENSG00000160949.16","TONSL","chr8","-",144432284,144433759,144433587,144433759,144431077,144431151,5437,487468,"4,0",417382,"0,1",298,149,1,1,"0.984,1.0","1.0,0.995",-0.006]
[5459,"ENSG00000186591.12","UBE2H","chr7","-",129880878,129880971,129880894,129880971,129879567,129879642,5459,"0,0","60,74","1,3",134189,165,149,1,1,"0.0,0.0","0.007,0.014",-0.011]
[5479,"ENSG00000122783.16","CYREN","chr7","-",135168930,135169060,135168968,135169060,135167731,135167807,5479,"41,58","34,46","42,54","2,2",187,149,{"v":3.33066907388E-15,"d":"3.33E-15"},{"v":1.01793573570457E-13,"d":"1.02E-13"},"0.49,0.501","0.944,0.956",-0.454]
[5484,"ENSG00000165516.10","KLHDC2","chr14","+",49779594,49779806,49779594,49779675,49780212,49780322,5484,258265,"0,0","27,31","0,2",280,149,0.552975011275,0.967931202619012,"1.0,1.0","1.0,0.892",0.054]
[5494,"ENSG00000157764.13","BRAF","chr7","-",140808882,140808995,140808891,140808995,140807959,140808062,5494,"0,4","46,48","1,0","51,63",158,149,0.412417950226,0.794554496513486,"0.0,0.073","0.018,0.0",0.027]
[5504,"ENSG00000178685.13","PARP10","chr8","-",143984007,143984104,143984034,143984104,143983166,143983811,5504,"73,42","4,3","46,45","0,5",176,149,0.899651126836,1,"0.939,0.922","1.0,0.884",-0.011]
[5513,"ENSG00000055609.17","KMT2C","chr7","-",152158856,152159072,152158862,152159072,152157760,152157925,5513,"3,6","47,69","1,1","70,77",155,149,0.004252880315,0.0185683792324553,"0.058,0.077","0.014,0.012",0.055]
[5527,"ENSG00000157353.16","FUK","chr16","+",70466881,70467471,70466881,70466954,70468848,70468968,5527,"27,33","0,2","64,93","6,3",298,149,0.0800934795373,0.219583499710059,"1.0,0.892","0.842,0.939",0.055]
[5536,"ENSG00000171130.18","ATP6V0E2","chr7","+",149878677,149878790,149878677,149878746,149879165,149879225,5536,"74,56","0,0","79,63","1,0",193,149,1,1,"1.0,1.0","0.984,1.0",0.008]
[5557,"ENSG00000182372.9","CLN8","chr8","+",1763799,1763925,1763799,1763885,1770931,1771597,5557,"1,0","109,76","2,0","40,86",189,149,1,1,"0.007,0.0","0.038,0.0",-0.015]
[5573,"ENSG00000130299.16","GTPBP3","chr19","+",17337558,17337664,17337558,17337576,17338007,17338255,5573,143129,"11,0","30,44","0,2",237,149,0.141824948985,0.346548862281803,"0.891,1.0","1.0,0.933",-0.021]
[5583,"ENSG00000114744.8","COMMD2","chr3","-",149751322,149751485,149751402,149751485,149750677,149750851,5583,"6,6",189154,"20,12",197209,229,149,0.0118130909489,0.0450976694209603,"0.02,0.025","0.062,0.036",-0.027]
[5594,"ENSG00000120913.23","PDLIM2","chr8","+",22579129,22579527,22579129,22579209,22580602,22580697,5594,"36,40","1,1","42,53","1,1",298,149,0.955132614764,1,"0.947,0.952","0.955,0.964",-0.01]
[5613,"ENSG00000100519.11","PSMC6","chr14","+",52708482,52708706,52708482,52708522,52711100,52711168,5613,"10,1","0,0","51,46","2,1",298,149,0.657774029741,1,"1.0,1.0","0.927,0.958",0.057]
[5624,"ENSG00000147471.11","PLPBP","chr8","+",37762599,37762758,37762599,37762700,37765525,37765633,5624,567610,"4,6",508479,"0,1",207,149,0.801834688522,1,"0.99,0.987","1.0,0.997",-0.01]
[5639,"ENSG00000148950.10","IMMP1L","chr11","-",31469739,31469797,31469757,31469797,31456259,31456386,5639,"5,5","0,0","6,1","2,0",167,149,0.833453310377,1,"1.0,1.0","0.728,1.0",0.136]
[5655,"ENSG00000259316.11","AC087632.1","chr15","-",64365973,64366075,64365985,64366075,64342542,64342685,5655,328266,176190,185145,91120,161,149,0.868498236129,1,"0.633,0.564","0.653,0.528",0.008]
[5671,"ENSG00000136811.16","ODF2","chr9","+",128460941,128461067,128460941,128461010,128469182,128469353,5671,270270,97104,166151,"42,57",206,149,0.32169246397,0.663999909322574,"0.668,0.653","0.741,0.657",-0.038]
[5678,"ENSG00000197958.12","RPL12","chr9","-",127449609,127451405,127451049,127451405,127449280,127449362,5678,2493824476,"0,0",2117422121,"0,2",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[5693,"ENSG00000139116.18","KIF21A","chr12","-",39321347,39322882,39322667,39322882,39319905,39320013,5693,"2,5","42,17","0,5","16,12",298,149,0.915754004854,1,"0.023,0.128","0.0,0.172",-0.01]
[5699,"ENSG00000164548.10","TRA2A","chr7","-",23522131,23522432,23522353,23522432,23521706,23521840,5699,150127,"9,12",148179,"12,5",298,149,0.28237354897,0.604411985638531,"0.893,0.841","0.86,0.947",-0.036]
[5713,"ENSG00000156170.12","NDUFAF6","chr8","+",95031994,95032098,95031994,95032094,95035453,95035576,5713,"112,95",133146,"71,73","123,68",153,149,0.841067258879,1,"0.451,0.388","0.36,0.511",-0.016]
[5718,"ENSG00000138346.14","DNA2","chr10","-",68431856,68431971,68431861,68431971,68430435,68430660,5718,"12,24",215200,"4,5","38,49",154,149,0.737802626935,1,"0.051,0.104","0.092,0.09",-0.013]
[5734,"ENSG00000164010.14","ERMAP","chr1","+",42825622,42825738,42825622,42825735,42840269,42840296,5734,"2,1","0,0","16,12","2,0",152,149,0.555815456002,0.970300853561779,"1.0,1.0","0.887,1.0",0.056]
[5747,"ENSG00000154188.9","ANGPT1","chr8","-",107321895,107322128,107321898,107322128,107303239,107303367,5747,"57,48","56,36","46,68","44,46",152,149,0.690007064556,1,"0.499,0.567","0.506,0.592",-0.016]
[5758,"ENSG00000103037.11","SETD6","chr16","+",58515790,58516097,58515790,58515880,58516201,58516343,5758,"88,89","9,3","66,56","2,1",298,149,0.0322167096165,0.10496285949555,"0.83,0.937","0.943,0.966",-0.071]
[5765,"ENSG00000156795.7","WDYHV1","chr8","+",123441305,123441497,123441305,123441349,123467078,123470028,5765,152148,"2,5",197247,"8,4",297,149,0.612837645909,1,"0.974,0.937","0.925,0.969",0.008]
[5782,"ENSG00000099250.17","NRP1","chr10","-",33202890,33202995,33202911,33202995,33197649,33197709,5782,"36,27","7,14","54,46","15,8",170,149,0.369976774559,0.735169955800835,"0.818,0.628","0.759,0.834",-0.074]
[5798,"ENSG00000158106.13","RHPN1","chr8","+",143379828,143380175,143379828,143379985,143380588,143380783,5798,"1,6","2,0","7,8","0,0",298,149,0.175858395908,0.412354974537546,"0.2,1.0","1.0,1.0",-0.4]
[5804,"ENSG00000104529.17","EEF1D","chr8","-",143593874,143594071,143593892,143594071,143586728,143586852,5804,"4,2","2,2","0,2","1,3",167,149,0.0449960667829,0.13814717079065,"0.641,0.472","0.0,0.373",0.37]
[5821,"ENSG00000064933.17","PMS1","chr2","+",189863742,189864228,189863742,189863974,189867798,189867929,5821,732650,"3,10",412426,"7,0",298,149,0.679639917586,1,"0.992,0.97","0.967,1.0",-0.003]
[5828,"ENSG00000011295.15","TTC19","chr17","+",16000117,16000382,16000117,16000245,16004200,16004262,5828,"33,26","0,0",96133,"2,0",286,149,1,1,"1.0,1.0","0.962,1.0",0.019]
[5839,"ENSG00000049656.13","CLPTM1L","chr5","-",1324762,1325816,1325750,1325816,1322876,1322911,5839,"13,10","0,0",247241,"10,4",298,149,0.00891299554972,0.035330142271145,"1.0,1.0","0.925,0.968",0.053]
[5857,"ENSG00000111846.17","GCNT2","chr6","+",10528630,10529836,10528630,10528841,10621350,10621443,5857,118106,"39,26",150143,"11,5",298,149,{"v":1.90945770306e-09,"d":"1.91E-09"},{"v":3.02087440728227e-08,"d":"3.02E-08"},"0.602,0.671","0.872,0.935",-0.267]
[5861,"ENSG00000150756.13","FAM173B","chr5","-",10236477,10236615,10236521,10236615,10235210,10235261,5861,247217,"8,2",81136,"1,3",193,149,0.549732866512,0.964713111210916,"0.96,0.988","0.984,0.972",-0.004]
[5874,"ENSG00000146067.15","FAM193B","chr5","-",177523158,177523265,177523162,177523265,177521973,177522071,5874,"15,12","4,5","14,8","5,9",153,149,0.233454326015,0.520842314240848,"0.785,0.7","0.732,0.464",0.144]
[5892,"ENSG00000090316.15","MAEA","chr4","+",1311978,1312238,1311978,1312161,1322380,1322503,5892,"1,4","12,4","7,4","5,2",226,149,0.0224983049439,0.0778754068811056,"0.052,0.397","0.48,0.569",-0.3]
[5901,"ENSG00000235257.8","ITGA9-AS1","chr3","-",37851423,37851492,37851446,37851492,37821013,37821100,5901,"2,2","4,1","4,5","0,0",172,149,{"v":8.25817893824e-06,"d":"8.26E-06"},{"v":6.96249913930924e-05,"d":"6.96E-05"},"0.302,0.634","1.0,1.0",-0.532]
[5918,"ENSG00000196730.12","DAPK1","chr9","+",87497680,87498107,87497680,87497772,87498969,87499139,5918,"97,94","1,0",206259,"5,11",298,149,1.27716632023E-3,6.6056515735742E-3,"0.98,1.0","0.954,0.922",0.052]
[5943,"ENSG00000123349.13","PFDN5","chr12","+",53296429,53297924,53296429,53296551,53298044,53298150,5943,39743769,"0,0",43424786,"0,1",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[5948,"ENSG00000126746.17","ZNF384","chr12","-",6689097,6689510,6689367,6689510,6688166,6688226,5948,"111,95","28,49",119145,"31,44",298,149,0.346611120225,0.699983150257107,"0.665,0.492","0.657,0.622",-0.061]
[5972,"ENSG00000090097.21","PCBP4","chr3","-",51959894,51960320,51960188,51960320,51959576,51959651,5972,"32,39","2,2","28,29","5,6",298,149,0.0179818144758,0.0648285389177802,"0.889,0.907","0.737,0.707",0.176]
[5988,"ENSG00000242802.7","AP5Z1","chr7","+",4789831,4790591,4789831,4789929,4790672,4790887,5988,144169,"1,4",276361,"4,1",298,149,0.393224401102,0.765805232993359,"0.986,0.955","0.972,0.994",-0.013]
[6001,"ENSG00000148303.16","RPL7A","chr9","+",133348217,133348573,133348217,133348246,133348921,133349042,6001,"23,22",22972156,"28,17",30763226,298,149,1,1,"0.005,0.005","0.005,0.003",1E-3]
[6009,"ENSG00000160326.13","SLC2A6","chr9","-",133473414,133474088,133473979,133474088,133473104,133473250,6009,"24,41","6,6","40,47","4,2",298,149,0.0445448395485,0.137074766551133,"0.667,0.774","0.833,0.922",-0.157]
[6017,"ENSG00000237441.9","RGL2","chr6","-",33293794,33294066,33294033,33294066,33293412,33293524,6017,"26,19","0,0","25,30","2,1",298,149,0.370633875832,0.735660375682777,"1.0,1.0","0.862,0.938",0.1]
[6037,"ENSG00000168090.9","COPS6","chr7","+",100090591,100091152,100090591,100090654,100091237,100091330,6037,11801078,"0,0",441475,"1,0",298,149,1,1,"1.0,1.0","0.995,1.0",2E-3]
[6054,"ENSG00000168283.13","BMI1","chr10","+",22326430,22326986,22326430,22326561,22327594,22327650,6054,521441,"2,4",494530,"1,3",298,149,0.856716627032,1,"0.992,0.982","0.996,0.989",-0.005]
[6059,"ENSG00000169241.18","SLC50A1","chr1","+",155136298,155136396,155136298,155136376,155136827,155136951,6059,"11,18",221220,"5,0",107159,169,149,0.00118633614121,0.00617744637325129,"0.042,0.067","0.04,0.0",0.035]
[6073,"ENSG00000150093.18","ITGB1","chr10","-",32911447,32911670,32911526,32911670,32910222,32910455,6073,15451515,"0,0",12621209,"1,0",228,149,1,1,"1.0,1.0","0.999,1.0",0]
[6086,"ENSG00000189180.15","ZNF33A","chr10","+",38016870,38017020,38016870,38017015,38017290,38017386,6086,"10,4",177157,"23,20",206197,154,149,1.611857104E-3,0.00808428044278344,"0.052,0.024","0.097,0.089",-0.055]
[6102,"ENSG00000122952.16","ZWINT","chr10","-",56360017,56360383,56360292,56360383,56359686,56359853,6102,20111873,"4,2",701796,"1,4",298,149,1,1,"0.996,0.998","0.997,0.99",0.003]
[6115,"ENSG00000156042.17","CFAP70","chr10","-",73299600,73299665,73299604,73299665,73298906,73299097,6115,"5,6","0,0","13,8","1,1",153,149,0.427068875769,0.813169374428832,"1.0,1.0","0.927,0.886",0.093]
[6134,"ENSG00000102225.15","CDK16","chrX","+",47222260,47222380,47222260,47222342,47223551,47223759,6134,"61,81","50,51","21,24","6,14",187,149,0.138324413022,0.339747496641706,"0.493,0.559","0.736,0.577",-0.13]
[6139,"ENSG00000206149.10","HERC2P9","chr15","+",28655272,28655691,28655272,28655420,28655795,28656026,6139,"66,66","48,35","59,75","67,81",298,149,0.0080358111494,0.0323295648261949,"0.407,0.485","0.306,0.316",0.135]
[6154,"ENSG00000119943.12","PYROXD2","chr10","-",98410612,98410958,98410938,98410958,98407903,98407997,6154,"5,12","37,28","18,18","21,50",298,149,0.0569326267316,0.167436084849249,"0.063,0.176","0.3,0.153",-0.107]
[6161,"ENSG00000255339.6","AL133352.1","chr10","-",100529365,100529506,100529379,100529506,100526974,100527074,6161,"24,32",27212728,"94,73",10871142,163,149,0,0,"0.008,0.011","0.073,0.055",-0.054]
[6172,"ENSG00000166197.16","NOLC1","chr10","+",102159192,102159338,102159192,102159308,102159432,102159568,6172,277329,24282439,174128,930901,179,149,0.0290656982075,0.0966879348535204,"0.087,0.101","0.135,0.106",-0.026]
[6184,"ENSG00000121578.12","B4GALT4","chr3","-",119240764,119240878,119240849,119240878,119236852,119237070,6184,"1,2","8,5","1,0","26,23",234,149,0.212373802262,0.480993129417809,"0.074,0.203","0.024,0.0",0.127]
[6204,"ENSG00000213397.10","HAUS7","chrX","-",153454393,153455766,153455541,153455766,153447669,153447909,6204,284267,"8,3",75105,"3,0",298,149,0.341502125213,0.692923399291107,"0.947,0.978","0.926,1.0",-1E-3]
[6210,"ENSG00000173531.15","MST1","chr3","-",49686946,49687067,49686950,49687067,49686683,49686802,6210,"2,5","6,2","9,5","20,7",153,149,0.535397064,0.948583928608695,"0.245,0.709","0.305,0.41",0.119]
[6232,"ENSG00000070047.11","PHRF1","chr11","+",581491,581606,581491,581597,581961,582081,6232,125101,"16,14","110,92","9,11",158,149,0.324607457232,0.666690917316123,"0.88,0.872","0.92,0.887",-0.027]
[6241,"ENSG00000177542.10","SLC25A22","chr11","-",796042,796237,796113,796237,794986,795169,6241,"22,39","0,0","50,52","1,0",220,149,1,1,"1.0,1.0","0.971,1.0",0.014]
[6252,"ENSG00000021762.19","OSBPL5","chr11","-",3165215,3165300,3165222,3165300,3129012,3129169,6252,"53,55","0,1","21,15","1,0",156,149,1,1,"1.0,0.981","0.953,1.0",0.014]
[6260,"ENSG00000179364.13","PACS2","chr14","+",105381913,105382058,105381913,105382046,105382476,105382581,6260,"5,8","82,68","3,1","49,33",161,149,0.152002409824,0.36648182987149,"0.053,0.098","0.054,0.027",0.035]
[6278,"ENSG00000122970.15","IFT81","chr12","+",110124334,110124861,110124334,110124443,110127359,110127524,6278,"61,43","11,11","47,49","13,13",298,149,0.449402646346,0.839936356739101,"0.735,0.662","0.644,0.653",0.05]
[6282,"ENSG00000198336.9","MYL4","chr17","+",47209065,47209155,47209065,47209091,47209388,47209557,6282,"40,57","43,64","14,24","15,25",213,149,0.89476162082,1,"0.394,0.384","0.395,0.402",-0.01]
[6294,"ENSG00000166340.16","TPP1","chr11","-",6617625,6618915,6618775,6618915,6616974,6617428,6294,417472,"1,0",470447,"0,0",298,149,1,1,"0.995,1.0","1.0,1.0",-2E-3]
[6306,"ENSG00000133816.15","MICAL2","chr11","+",12138389,12138464,12138389,12138460,12153223,12153316,6306,"3,0","0,1","1,1","0,0",153,149,1,1,"1.0,0.0","1.0,1.0",-0.5]
[6323,"ENSG00000177054.13","ZDHHC13","chr11","+",19166301,19170568,19166301,19166385,19172722,19172820,6323,198179,"0,1",150145,"0,0",298,149,1,1,"1.0,0.989","1.0,1.0",-0.006]
[6341,"ENSG00000007372.22","PAX6","chr11","-",31801668,31801776,31801761,31801776,31800690,31800856,6341,"59,46","11,1","70,70","0,1",242,149,{"v":6.69854094666E-5,"d":"6.70E-05"},4.72853697533912E-4,"0.768,0.966","1.0,0.977",-0.121]
[6348,"ENSG00000184937.13","WT1","chr11","-",32417423,32417654,32417576,32417654,32416489,32416540,6348,"2,3",81100,"0,2","20,18",298,149,0.474187122083,0.866844866268197,"0.012,0.015","0.0,0.053",-0.013]
[6374,"ENSG00000198561.13","CTNND1","chr11","+",57761796,57762119,57761796,57762046,57789036,57789155,6374,"30,25",127124,"39,21",108153,222,149,0.842779617191,1,"0.137,0.119","0.195,0.084",-0.012]
[6388,"ENSG00000145819.16","ARHGAP26","chr5","+",143207197,143207473,143207197,143207308,143213996,143214088,6388,"0,0","4,2","0,2","3,3",298,149,0.732810025126,1,"0.0,0.0","0.0,0.25",-0.125]
[6395,"ENSG00000008128.22","CDK11A","chr1","-",1719327,1719455,1719357,1719455,1712263,1712400,6395,102120,"1,0",213146,"0,0",179,149,1,1,"0.988,1.0","1.0,1.0",-0.006]
[6405,"ENSG00000149532.15","CPSF7","chr11","-",61420469,61421608,61421389,61421608,61419921,61420094,6405,559511,"11,11",568649,"17,10",298,149,0.778941314098,1,"0.962,0.959","0.944,0.97",0.003]
[6418,"ENSG00000149503.12","INCENP","chr11","+",62123997,62124163,62123997,62124055,62128150,62128301,6418,297217,"0,0",399478,"0,1",257,149,1,1,"1.0,1.0","1.0,0.996",2E-3]
[6429,"ENSG00000168000.14","BSCL2","chr11","-",62706202,62706344,62706258,62706344,62705300,62705617,6429,"26,32","0,0","16,16","3,1",205,149,0.0170232361511,0.0619539832589762,"1.0,1.0","0.795,0.921",0.142]
[6442,"ENSG00000110046.12","ATG2A","chr11","-",64902509,64902680,64902515,64902680,64902259,64902386,6442,"12,18","13,16","20,26","9,13",155,149,0.0540092286259,0.16033879741635,"0.47,0.52","0.681,0.658",-0.174]
[6461,"ENSG00000173039.18","RELA","chr11","-",65661686,65662088,65661936,65662088,65660123,65660215,6461,654744,"0,1",589628,"4,7",298,149,0.327097260897,0.669503868479818,"1.0,0.997","0.987,0.978",0.016]
[6467,"ENSG00000173120.14","KDM2A","chr11","+",67250085,67250798,67250085,67250346,67252693,67252857,6467,682729,"8,9",12491224,"4,7",298,149,0.0232779101505,0.0803670594990625,"0.977,0.976","0.994,0.989",-0.015]
[6478,"ENSG00000197345.12","MRPL21","chr11","-",68896468,68896678,68896514,68896678,68893402,68893455,6478,"9,24",12961175,"21,27",795821,195,149,0.00162941168599,0.00816071271782142,"0.005,0.015","0.02,0.025",-0.012]
[6486,"ENSG00000172890.12","NADSYN1","chr11","+",71458427,71458556,71458427,71458544,71463431,71463485,6486,"6,4",427485,"2,8",217185,161,149,0.14856199152,0.359799618363836,"0.013,0.008","0.008,0.038",-0.013]
[6495,"ENSG00000151575.14","TEX9","chr15","+",56365578,56365893,56365578,56365670,56412301,56412436,6495,"10,3","4,3","17,5","0,0",298,149,{"v":3.88313498911e-07,"d":"3.88E-07"},{"v":4.29781545399643e-06,"d":"4.30E-06"},"0.556,0.333","1.0,1.0",-0.555]
[6508,"ENSG00000148288.12","GBGT1","chr9","-",133155900,133156065,133156014,133156065,133152952,133155312,6508,485522,"1,0",352314,"0,1",263,149,1,1,"0.996,1.0","1.0,0.994",1E-3]
[6518,"ENSG00000150672.17","DLG2","chr11","-",85626586,85626753,85626598,85626753,85598656,85598788,6518,"0,0","16,10","4,2","13,11",161,149,0.000671476193412,0.00371974299110519,"0.0,0.0","0.222,0.144",-0.183]
[6538,"ENSG00000166012.16","TAF1D","chr11","-",93731145,93731216,93731149,93731216,93730681,93730712,6538,"30,22",29092691,"38,55",16001836,153,149,{"v":1.31959070893e-07,"d":"1.32E-07"},{"v":1.56001723589768e-06,"d":"1.56E-06"},"0.01,0.008","0.023,0.028",-0.017]
[6550,"ENSG00000150316.11","CWC15","chr11","-",94970976,94971487,94971374,94971487,94969988,94970096,6550,18881596,"0,0",15211637,"1,3",298,149,1,1,"1.0,1.0","0.999,0.996",2E-3]
[6567,"ENSG00000095787.21","WAC","chr10","+",28614566,28616362,28614566,28614685,28617656,28617784,6567,875674,"4,1",820833,"10,5",298,149,0.164029033834,0.389713857329101,"0.991,0.997","0.976,0.988",0.012]
[6576,"ENSG00000094841.13","UPRT","chrX","+",75300866,75301015,75300866,75300965,75303404,75304600,6576,"41,19",125128,"48,38","50,46",199,149,{"v":2.31112039506e-08,"d":"2.31E-08"},{"v":3.06194990271619e-07,"d":"3.06E-07"},"0.197,0.1","0.418,0.382",-0.252]
[6610,"ENSG00000172269.18","DPAGT1","chr11","-",119097444,119097551,119097463,119097551,119097141,119097297,6610,"33,39",670682,"37,33",137154,168,149,{"v":7.83817455385e-13,"d":"7.84E-13"},{"v":1.81730779849823E-11,"d":"1.82E-11"},"0.042,0.048","0.193,0.16",-0.132]
[6624,"ENSG00000166261.10","ZNF202","chr11","-",123740392,123740536,123740416,123740536,123740116,123740232,6624,"17,33","59,77","8,9","67,64",173,149,0.000534930292947,0.00304039622008836,"0.199,0.27","0.093,0.108",0.134]
[6631,"ENSG00000154134.14","ROBO3","chr11","+",124877518,124877752,124877518,124877658,124878297,124878436,6631,"14,19","2,2","29,13","4,2",243,149,0.673589606916,1,"0.811,0.853","0.816,0.799",0.025]
[6639,"ENSG00000123329.17","ARHGAP9","chr12","-",57476070,57476454,57476363,57476454,57475832,57475931,6639,369405,"0,0",183196,"1,4",298,149,0.566882050391,0.981415690071834,"1.0,1.0","0.989,0.961",0.025]
[6664,"ENSG00000151062.14","CACNA2D4","chr12","-",1799674,1800438,1800385,1800438,1797417,1797535,6664,"110,93","0,0",154202,"1,0",298,149,1,1,"1.0,1.0","0.987,1.0",0.006]
[6673,"ENSG00000111247.14","RAD51AP1","chr12","+",4543762,4543911,4543762,4543904,4548091,4548178,6673,"11,21","20,15","70,49","101,88",156,149,0.358552912197,0.719379378854033,"0.344,0.572","0.398,0.347",0.085]
[6682,"ENSG00000111642.15","CHD4","chr12","-",6581037,6581173,6581043,6581173,6580581,6580679,6682,"1,4","7,3","4,1","0,2",155,149,0.0422987766531,0.131745871231629,"0.121,0.562","1.0,0.325",-0.321]
[6696,"ENSG00000111679.16","PTPN6","chr12","+",6951608,6952177,6951608,6951731,6954804,6954994,6696,9271078,"4,0",1049997,"1,2",298,149,1,1,"0.991,1.0","0.998,0.996",-1E-3]
[6709,"ENSG00000059804.15","SLC2A3","chr12","-",7929683,7930642,7930479,7930642,7925843,7925948,6709,364295,"2,1",251259,"12,19",298,149,{"v":2.86814116901e-09,"d":"2.87E-09"},{"v":4.3828782238934e-08,"d":"4.38E-08"},"0.989,0.993","0.913,0.872",0.098]
[6732,"ENSG00000092199.17","HNRNPC","chr14","-",21230957,21231072,21230996,21231072,21212959,21213117,6732,683651,"2,0",772870,"0,0",188,149,1,1,"0.996,1.0","1.0,1.0",-2E-3]
[6734,"ENSG00000092199.17","HNRNPC","chr14","-",21233952,21234229,21234077,21234229,21230996,21231072,6734,1943718287,"1,0",2070122746,"0,0",274,149,1,1,"1.0,1.0","1.0,1.0",0]
[6751,"ENSG00000214548.16","MEG3","chr14","+",100829033,100831534,100829033,100829749,100835738,100835879,6751,753574,"2,3",806858,"8,11",298,149,0.0271038787188,0.0911768377913853,"0.995,0.99","0.981,0.975",0.014]
[6769,"ENSG00000134291.11","TMEM106C","chr12","+",47964208,47964462,47964208,47964423,47967207,47967261,6769,"9,41","2,1","46,26","88,94",188,149,{"v":2.16493489802E-14,"d":"2.16E-14"},{"v":6.00251472459709e-13,"d":"6.00E-13"},"0.781,0.97","0.293,0.18",0.639]
[6782,"ENSG00000156650.13","KAT6B","chr10","+",74975398,74977437,74975398,74975781,74979223,74979339,6782,135147,"0,0","112,97","0,1",298,149,1,1,"1.0,1.0","1.0,0.98",0.01]
[6791,"ENSG00000135451.12","TROAP","chr12","+",49323844,49324037,49323844,49323946,49324211,49324296,6791,343317,"5,2",600575,"5,16",240,149,0.129508975916,0.322699519810051,"0.977,0.99","0.987,0.957",0.012]
[6806,"ENSG00000161800.12","RACGAP1","chr12","-",50016630,50016715,50016634,50016715,50006433,50006636,6806,517516,"0,4",470504,"3,0",153,149,1,1,"1.0,0.992","0.993,1.0",0]
[6813,"ENSG00000110911.15","SLC11A2","chr12","-",50991486,50991672,50991598,50991672,50990794,50990948,6813,"4,6",220245,"25,9",330351,261,149,9.34376515292E-3,0.036766724767781,"0.01,0.014","0.041,0.014",-0.015]
[6838,"ENSG00000139651.10","ZNF740","chr12","+",53181676,53182190,53181676,53181992,53184890,53185040,6838,"64,57",172190,249193,127132,298,149,0,0,"0.157,0.13","0.495,0.422",-0.315]
[6850,"ENSG00000223812.6","AC073365.1","chr3","+",191559677,191559754,191559677,191559750,191569599,191569824,6850,"20,7","2,0","11,3","0,0",153,149,0.404457040941,0.784273404189487,"0.907,1.0","1.0,1.0",-0.046]
[6853,"ENSG00000182796.14","TMEM198B","chr12","+",55832958,55833038,55832958,55833014,55833446,55833541,6853,"6,28","3,2","3,4","2,1",173,149,0.6368976193,1,"0.633,0.923","0.564,0.775",0.109]
[6868,"ENSG00000076108.11","BAZ2A","chr12","-",56601179,56601402,56601245,56601402,56600942,56601098,6868,497527,"1,2",512479,"4,4",215,149,1,1,"0.997,0.995","0.989,0.988",0.008]
[6883,"ENSG00000135506.15","OS9","chr12","+",57715759,57716193,57715759,57715970,57716411,57716512,6883,557562,"0,0",826866,"22,10",298,149,{"v":7.14487664888e-06,"d":"7.14E-06"},{"v":6.13934368918938e-05,"d":"6.14E-05"},"1.0,1.0","0.949,0.977",0.037]
[6887,"ENSG00000103034.14","NDRG4","chr16","+",58503797,58503957,58503797,58503903,58504153,58504274,6887,"0,0","2,3","2,0","2,0",203,149,1,1,"0.0,0.0","0.423,NA",-0.423]
[6912,"ENSG00000165689.16","ENTR1","chr9","-",136405090,136405202,136405117,136405202,136404630,136404693,6912,337309,"27,20",272271,"19,12",176,149,0.320966661368,0.662756111899605,"0.914,0.929","0.924,0.95",-0.016]
[6936,"ENSG00000059758.7","CDK17","chr12","-",96399333,96399404,96399344,96399404,96334718,96334865,6936,"3,0","0,0","0,4","1,0",160,149,1,1,"1.0,NA","0.0,1.0",0.5]
[6950,"ENSG00000135913.10","USP37","chr2","-",218562672,218562813,218562717,218562813,218560819,218560883,6950,160178,"21,21",161135,"13,13",194,149,0.190890249956,0.440497063283279,"0.854,0.867","0.905,0.889",-0.036]
[6960,"ENSG00000162734.12","PEA15","chr1","+",160211542,160211716,160211542,160211650,160213109,160213265,6960,621653,"11,11",671656,"3,3",215,149,5.59567987382E-3,0.0236442749735096,"0.975,0.976","0.994,0.993",-0.018]
[6965,"ENSG00000173064.12","HECTD4","chr12","-",112264083,112264212,112264089,112264212,112259111,112259265,6965,"0,2","0,0","7,3","2,0",155,149,1,1,"NA,1.0","0.771,1.0",0.115]
[6981,"ENSG00000135090.13","TAOK3","chr12","-",118359505,118359720,118359520,118359720,118296941,118297163,6981,"2,6","2,2","1,0","0,0",164,149,1,1,"0.476,0.732","1.0,NA",-0.396]
[6995,"ENSG00000089053.12","ANAPC5","chr12","-",121318276,121318608,121318500,121318608,121308356,121308691,6995,150143,"0,0",206192,"21,4",298,149,{"v":3.74082254395e-07,"d":"3.74E-07"},{"v":4.1488421575066e-06,"d":"4.15E-06"},"1.0,1.0","0.831,0.96",0.105]
[7008,"ENSG00000051825.14","MPHOSPH9","chr12","-",123218375,123218499,123218398,123218499,123214743,123214834,7008,240242,"5,6",110131,"2,8",172,149,0.262812632739,0.570948768781535,"0.977,0.972","0.979,0.934",0.018]
[7023,"ENSG00000151092.16","NGLY1","chr3","-",25736308,25737455,25737333,25737455,25736003,25736149,7023,"55,52",264259,"21,36","27,11",298,149,{"v":8.68028383083e-06,"d":"8.68E-06"},{"v":7.2955073009429e-05,"d":"7.30E-05"},"0.094,0.091","0.28,0.621",-0.358]
[7038,"ENSG00000162852.13","CNST","chr1","+",246633923,246634587,246633923,246634010,246641748,246641770,7038,421322,"0,0",550546,"5,4",298,149,0.647246262914,1,"1.0,1.0","0.982,0.986",0.016]
[7058,"ENSG00000102743.14","SLC25A15","chr13","+",40799056,40799315,40799056,40799172,40805117,40805255,7058,487452,"1,2",353370,"0,0",292,149,1,1,"0.996,0.991","1.0,1.0",-0.006]
[7066,"ENSG00000253710.3","ALG11","chr13","+",52012410,52012574,52012410,52012462,52015782,52017713,7066,"14,8","43,28","29,28","59,58",261,149,0.10424957652,0.271159802756808,"0.157,0.14","0.219,0.216",-0.069]
[7074,"ENSG00000103245.13","CIAO3","chr16","-",739539,739738,739642,739738,737185,737329,7074,"3,21",164163,"3,2",155205,252,149,0.000132335099418,0.00087810378803994,"0.011,0.071","0.011,0.006",0.032]
[7087,"ENSG00000171453.18","POLR1C","chr6","+",43519705,43519905,43519705,43519838,43520065,43520185,7087,"53,31",325371,"65,33",339321,216,149,0.286769904154,0.610905075027471,"0.101,0.054","0.117,0.066",-0.014]
[7104,"ENSG00000082641.15","NFE2L1","chr17","+",48050606,48051628,48050606,48050781,48056385,48056598,7104,883825,"0,1",10721105,"0,0",298,149,1,1,"1.0,0.998","1.0,1.0",-1E-3]
[7124,"ENSG00000175294.5","CATSPER1","chr11","-",66018787,66018902,66018826,66018902,66017059,66017174,7124,"7,2","2,2","8,11","1,4",188,149,0.570849281806,0.987273004625581,"0.735,0.442","0.864,0.685",-0.186]
[7135,"ENSG00000092096.16","SLC22A17","chr14","-",23347459,23347731,23347513,23347731,23347100,23347212,7135,"10,23","17,24","9,10","8,17",203,149,0.930450215097,1,"0.302,0.413","0.452,0.302",-0.02]
[7140,"ENSG00000092010.14","PSME1","chr14","+",24138344,24138403,24138344,24138399,24138735,24138959,7140,"8,7","1,2","3,5","0,5",153,149,0.430325131575,0.816894057283755,"0.886,0.773","1.0,0.493",0.083]
[7160,"ENSG00000214078.12","CPNE1","chr20","-",35664759,35664932,35664878,35664932,35632794,35632923,7160,213152,"22,20",295323,"11,14",268,149,0.000118277407639,0.000792296607335219,"0.843,0.809","0.937,0.928",-0.107]
[7165,"ENSG00000163812.13","ZDHHC3","chr3","-",44959126,44959460,44959130,44959460,44958587,44958685,7165,"4,4","0,0","2,3","1,0",153,149,1,1,"1.0,1.0","0.661,1.0",0.169]
[7172,"ENSG00000182400.14","TRAPPC6B","chr14","-",39159449,39159550,39159482,39159550,39154210,39154294,7172,"4,2","4,0","8,11","4,3",182,149,0.960419215673,1,"0.45,1.0","0.621,0.75",0.039]
[7193,"ENSG00000137817.16","PARP6","chr15","-",72260477,72260688,72260537,72260688,72259607,72259661,7193,105182,227216,196165,237237,209,149,0.322337780498,0.664260512219943,"0.248,0.375","0.371,0.332",-0.04]
[7195,"ENSG00000197045.12","GMFB","chr14","-",54482121,54482202,54482152,54482202,54481394,54481458,7195,"3,0",213193,"3,2",210214,180,149,1,1,"0.012,0.0","0.012,0.008",-0.004]
[7220,"ENSG00000100564.8","PIGH","chr14","-",67593727,67593952,67593742,67593952,67592634,67592718,7220,"5,2",208221,"0,8",266249,164,149,0.965098507431,1,"0.021,0.008","0.0,0.028",1E-3]
[7234,"ENSG00000119616.11","FCF1","chr14","+",74713484,74713552,74713484,74713507,74714871,74714943,7234,431438,"3,0",509496,"0,0",194,149,1,1,"0.991,1.0","1.0,1.0",-0.004]
[7237,"ENSG00000198208.11","RPS6KL1","chr14","-",74909100,74910148,74909542,74910148,74908849,74908932,7237,"21,38","1,1","20,7","2,0",298,149,0.488398252363,0.882463620913865,"0.913,0.95","0.833,1.0",0.015]
[7256,"ENSG00000166140.17","ZFYVE19","chr15","+",40809851,40810216,40809851,40809970,40810648,40810757,7256,195154,"0,0",232210,"0,5",298,149,0.879907886142,1,"1.0,1.0","1.0,0.955",0.022]
[7263,"ENSG00000214517.9","PPME1","chr11","+",74250953,74251715,74250953,74251018,74253491,74254703,7263,512584,"1,4",255185,"0,0",298,149,1,1,"0.996,0.986","1.0,1.0",-0.009]
[7264,"ENSG00000117308.14","GALE","chr1","-",23796508,23796782,23796696,23796782,23796150,23796265,7264,498389,"47,39",138145,150223,298,149,0,0,"0.841,0.833","0.315,0.245",0.557]
[7265,"ENSG00000112759.17","SLC29A1","chr6","+",44229906,44230481,44229906,44230046,44230567,44230665,7265,17401841,"0,0",512523,"0,3",298,149,1,1,"1.0,1.0","1.0,0.989",0.006]
[7266,"ENSG00000006015.17","REX1BD","chr19","+",18588994,18589683,18588994,18589077,18590853,18590933,7266,703879,"60,68",698786,"4,3",298,149,0,0,"0.854,0.866","0.989,0.992",-0.13]
[7267,"ENSG00000080824.18","HSP90AA1","chr14","-",102085757,102086124,102085964,102086124,102085297,102085431,7267,1446413091,"0,4",1120411215,"3,2",298,149,1,1,"1.0,0.999","0.999,1.0",0]
[7269,"ENSG00000100865.14","CINP","chr14","-",102355767,102355897,102355771,102355897,102348510,102348759,7269,"16,17","0,0","19,22","1,4",153,149,0.0100105506155,0.0389629173377528,"1.0,1.0","0.949,0.843",0.104]
[7270,"ENSG00000100865.14","CINP","chr14","-",102355767,102355897,102355771,102355897,102349918,102350048,7270,307349,"3,5",389330,"4,3",153,149,0.755480966633,1,"0.99,0.986","0.99,0.991",-2E-3]
[7271,"ENSG00000145495.15","2024-03-06","chr5","+",10417269,10417410,10417269,10417404,10421930,10422036,7271,"3,1","3,1","7,2","0,0",155,149,0.000132393041848,0.00087810378803994,"0.49,0.49","1.0,1.0",-0.51]
[7272,"ENSG00000145495.15","2024-03-06","chr5","+",10417269,10417410,10417269,10417404,10423734,10423835,7272,"6,1",812800,"8,3",663662,155,149,1,1,"0.007,0.001","0.011,0.004",-0.003]
[7274,"ENSG00000126214.21","KLC1","chr14","+",103662701,103662927,103662701,103662921,103669510,103669598,7274,505492,"3,0",486478,"3,0",155,149,1,1,"0.994,1.0","0.994,1.0",0]
[7275,"ENSG00000126214.21","KLC1","chr14","+",103679383,103679545,103679383,103679518,103684985,103685036,7275,176196,"7,12",149109,"25,30",176,149,{"v":2.51214724356e-07,"d":"2.51E-07"},{"v":2.85081013145764e-06,"d":"2.85E-06"},"0.955,0.933","0.835,0.755",0.149]
[7276,"ENSG00000126214.21","KLC1","chr14","+",103679383,103679545,103679383,103679518,103687080,103687211,7276,159199,"24,20",162110,"39,43",176,149,1.05266856923E-4,0.000714937403268708,"0.849,0.894","0.779,0.684",0.14]
[7277,"ENSG00000126214.21","KLC1","chr14","+",103679383,103679545,103679383,103679518,103693552,103693743,7277,85100,"3,0","86,58","2,2",176,149,0.46126110417,0.853793351455757,"0.96,1.0","0.973,0.961",0.013]
[7278,"ENSG00000126214.21","KLC1","chr14","+",103679383,103679545,103679383,103679518,103700654,103700727,7278,168145,"34,19","145,97","74,93",176,149,{"v":1.77022579928E-8,"d":"1.77E-08"},{"v":2.39849989277761e-07,"d":"2.40E-07"},"0.807,0.866","0.624,0.469",0.29]
[7279,"ENSG00000185024.16","BRF1","chr14","-",105246865,105247193,105247070,105247193,105241264,105241414,7279,"5,4","13,10","8,18","3,8",298,149,2.24170300982E-4,0.00140701522635026,"0.161,0.167","0.571,0.529",-0.386]
[7281,"ENSG00000182979.17","MTA1","chr14","+",105450057,105450324,105450057,105450184,105454192,105454310,7281,804770,"6,3",677745,"7,4",289,149,0.588060005266,1,"0.986,0.992","0.98,0.99",0.004]
[7282,"ENSG00000182979.17","MTA1","chr14","+",105469466,105469992,105469466,105469498,105470064,105470238,7282,10331036,"0,4",8691092,"1,0",298,149,1,1,"1.0,0.992","0.998,1.0",-0.003]
[7286,"ENSG00000128944.13","KNSTRN","chr15","+",40387158,40387218,40387158,40387206,40389505,40389611,7286,"4,4",800691,"2,9",540566,161,149,0.945488582554,1,"0.005,0.005","0.003,0.015",-0.004]
[7287,"ENSG00000012817.15","KDM5D","chrY","-",19708243,19708423,19708321,19708423,19707933,19708071,7287,574489,"43,21",111118,"1,11",227,149,0.456335218855,0.848178003531805,"0.898,0.939","0.986,0.876",-0.013]
[7288,"ENSG00000012817.15","KDM5D","chrY","-",19715583,19715739,19715614,19715739,19710375,19710472,7288,"8,3","0,0","21,23","2,2",180,149,0.026646575292,0.0898632780537103,"1.0,1.0","0.897,0.905",0.099]
[7289,"ENSG00000012817.15","KDM5D","chrY","-",19715583,19715739,19715614,19715739,19715351,19715499,7289,"10,3",191190,"11,10","37,21",180,149,{"v":4.1450060051e-09,"d":"4.15E-09"},{"v":6.21058142101195e-08,"d":"6.21E-08"},"0.042,0.013","0.197,0.283",-0.212]
[7290,"ENSG00000180229.12","HERC2P3","chr15","-",20443338,20443521,20443370,20443521,20440473,20440642,7290,"26,33",194256,"65,66",193234,181,149,{"v":9.1408688988e-06,"d":"9.14E-06"},{"v":7.62624460679364e-05,"d":"7.63E-05"},"0.099,0.096","0.217,0.188",-0.105]
[7291,"ENSG00000180229.12","HERC2P3","chr15","-",20453619,20453762,20453705,20453762,20453350,20453502,7291,"59,60","2,3","107,96","6,2",235,149,0.82645197577,1,"0.949,0.927","0.919,0.968",-0.006]
[7292,"ENSG00000177889.9","UBE2N","chr12","-",93411052,93411299,93411125,93411299,93410733,93410874,7292,32533324,"8,10",21202307,"19,11",222,149,0.865150286492,1,"0.996,0.996","0.987,0.993",0.006]
[7293,"ENSG00000174652.18","ZNF266","chr19","-",9418761,9418895,9418765,9418895,9418504,9418631,7293,"21,23","48,25","46,39","23,40",153,149,0.0296604098827,0.097939438157792,"0.299,0.473","0.661,0.487",-0.188]
[7294,"ENSG00000174652.18","ZNF266","chr19","-",9418761,9419299,9419050,9419299,9418504,9418631,7294,"106,86","23,22",181202,"15,17",298,149,{"v":8.68970671756e-05,"d":"8.69E-05"},0.000603121708822648,"0.697,0.662","0.858,0.856",-0.177]
[7295,"ENSG00000174652.18","ZNF266","chr19","-",9418761,9419299,9419216,9419299,9418504,9418631,7295,149131,"83,54",203213,107125,298,149,0.42568465286,0.811483877105249,"0.473,0.548","0.487,0.46",0.037]
[7296,"ENSG00000174652.18","ZNF266","chr19","-",9419050,9419299,9419216,9419299,9418504,9418631,7296,153133,"83,54",175197,107125,298,149,0.11347852579,0.290528791158691,"0.48,0.552","0.45,0.441",0.071]
[7297,"ENSG00000174652.18","ZNF266","chr19","-",9419050,9419299,9419216,9419299,9418765,9418895,7297,163131,"15,16",166192,"49,46",298,149,{"v":5.51481635029e-05,"d":"5.51E-05"},0.000398712327260885,"0.845,0.804","0.629,0.676",0.172]
[7298,"ENSG00000174652.18","ZNF266","chr19","-",9434064,9434235,9434074,9434235,9420064,9420218,7298,"8,6","16,1","7,2","1,2",159,149,0.25929853499,0.565336550904711,"0.319,0.849","0.868,0.484",-0.092]
[7299,"ENSG00000174652.18","ZNF266","chr19","-",9434064,9434235,9434074,9434235,9433773,9433786,7299,"6,4","45,45","2,5","18,10",159,149,0.289354814158,0.614707561356983,"0.111,0.077","0.094,0.319",-0.113]
[7300,"ENSG00000276550.4","HERC2P2","chr15","+",22561558,22561934,22561558,22561789,22562642,22562731,7300,"45,27","25,28","22,19","6,5",294,149,0.00926018390141,0.0364645162559915,"0.477,0.328","0.65,0.658",-0.252]
[7301,"ENSG00000276550.4","HERC2P2","chr15","+",22561558,22561934,22561558,22561789,22562948,22563087,7301,"36,16",478401,"13,10",271271,294,149,0.184477228686,0.428996094743106,"0.037,0.02","0.024,0.018",0.007]
[7302,"ENSG00000104695.12","PPP2CB","chr8","-",30799545,30799755,30799716,30799755,30797580,30797754,7302,17841675,"0,0",19922110,"0,1",298,149,1,1,"1.0,1.0","1.0,0.999",0]
[7306,"ENSG00000117155.16","SSX2IP","chr1","-",84671176,84671308,84671188,84671308,84670645,84670815,7306,"89,87","2,0","63,45","0,0",161,149,1,1,"0.976,1.0","1.0,1.0",-0.012]
[7307,"ENSG00000187994.13","RINL","chr19","-",38871077,38871870,38871797,38871870,38870569,38870651,7307,"35,18","0,0","26,38","0,2",298,149,0.461475079411,0.853883562593617,"1.0,1.0","1.0,0.905",0.047]
[7308,"ENSG00000187994.13","RINL","chr19","-",38876330,38876781,38876692,38876781,38873885,38873988,7308,"95,60","3,6",104133,"2,2",298,149,0.0286639695944,0.0955880300361299,"0.941,0.833","0.963,0.971",-0.08]
[7311,"ENSG00000198826.10","ARHGAP11A","chr15","+",32629594,32629762,32629594,32629675,32632978,32633108,7311,11071143,76111,18271771,"93,71",236,149,{"v":6.08136973673e-05,"d":"6.08E-05"},0.000435881813089123,"0.902,0.867","0.925,0.94",-0.048]
[7312,"ENSG00000198826.10","ARHGAP11A","chr15","+",32629594,32629762,32629594,32629675,32633062,32633108,7312,472529,"7,15",795754,"12,12",236,149,0.307201421478,0.643216918929435,"0.977,0.957","0.977,0.975",-0.009]
[7313,"ENSG00000198826.10","ARHGAP11A","chr15","+",32629594,32629762,32629594,32629675,32633932,32634041,7313,410477,"0,1",725672,"1,7",236,149,0.94719872526,1,"1.0,0.997","0.998,0.984",0.007]
[7316,"ENSG00000128923.10","MINDY2","chr15","+",58810229,58810388,58810229,58810286,58831773,58831916,7316,"36,38","0,0","23,43","1,0",251,149,1,1,"1.0,1.0","0.932,1.0",0.034]
[7317,"ENSG00000128923.10","MINDY2","chr15","+",58821716,58821823,58821716,58821819,58831773,58831916,7317,"0,0","35,40","0,1","45,35",153,149,1,1,"0.0,0.0","0.0,0.027",-0.013]
[7318,"ENSG00000128923.10","MINDY2","chr15","+",58810229,58810388,58810229,58810286,58847296,58847470,7318,"36,33","0,0","17,31","0,2",251,149,0.458022646369,0.849846089968558,"1.0,1.0","1.0,0.902",0.049]
[7320,"ENSG00000128928.8","IVD","chr15","+",40407635,40407812,40407635,40407725,40407938,40407990,7320,"27,12",452414,"36,39",289240,236,149,{"v":1.94689725785E-7,"d":"1.95E-07"},{"v":2.23291265457892e-06,"d":"2.23E-06"},"0.036,0.018","0.073,0.093",-0.056]
[7321,"ENSG00000128891.15","CCDC32","chr15","-",40564790,40565057,40564975,40565057,40562771,40563027,7321,"0,0","106,96","2,9",164162,298,149,0.442519036204,0.831689189267697,"0.0,0.0","0.006,0.027",-0.017]
[7322,"ENSG00000051180.16","RAD51","chr15","+",40695173,40695425,40695173,40695321,40698756,40698845,7322,352350,"0,0",309365,"0,1",253,149,1,1,"1.0,1.0","1.0,0.995",2E-3]
[7323,"ENSG00000104129.9","DNAJC17","chr15","-",40774967,40775108,40775030,40775108,40774355,40774436,7323,"7,12",323239,"8,12","119,97",212,149,0.00572744979893,0.0240499238629543,"0.015,0.034","0.045,0.08",-0.038]
[7324,"ENSG00000104129.9","DNAJC17","chr15","-",40779083,40779310,40779222,40779310,40776541,40776627,7324,"15,10",210197,"14,25",88139,288,149,0.000294444309107,0.00178760263960107,"0.036,0.026","0.076,0.085",-0.05]
[7325,"ENSG00000104129.9","DNAJC17","chr15","-",40779850,40779997,40779927,40779997,40779544,40779603,7325,"0,0",297231,"0,3",130137,226,149,1,1,"0.0,0.0","0.0,0.014",-0.007]
[7326,"ENSG00000062524.15","LTK","chr15","-",41507513,41507657,41507561,41507657,41507094,41507290,7326,"23,25","27,28","21,32","20,16",197,149,0.129583744709,0.322699519810051,"0.392,0.403","0.443,0.602",-0.125]
[7327,"ENSG00000140326.13","CDAN1","chr15","-",42727620,42727769,42727667,42727769,42726309,42726417,7327,120142,"18,37",131120,"27,29",196,149,0.767909866402,1,"0.835,0.745","0.787,0.759",0.017]
[7328,"ENSG00000159459.11","UBR1","chr15","-",43025373,43025429,43025380,43025429,43024828,43024983,7328,"6,6",347350,"14,21",221254,156,149,{"v":6.34935093236E-6,"d":"6.35E-06"},{"v":5.52640107850557e-05,"d":"5.53E-05"},"0.016,0.016","0.057,0.073",-0.049]
[7329,"ENSG00000159459.11","UBR1","chr15","-",43025373,43026663,43026560,43026663,43024828,43024983,7329,"19,17","0,0","61,53","24,24",298,149,{"v":5.78704761889e-09,"d":"5.79E-09"},{"v":8.50506260710636e-08,"d":"8.51E-08"},"1.0,1.0","0.56,0.525",0.458]
[7330,"ENSG00000166946.13","CCNDBP1","chr15","+",43185819,43186233,43185819,43185879,43189198,43189280,7330,408466,"22,14",367346,"66,66",298,149,{"v":1.35336186702E-13,"d":"1.35E-13"},{"v":3.48312606827778e-12,"d":"3.48E-12"},"0.903,0.943","0.735,0.724",0.194]
[7331,"ENSG00000166947.13","EPB42","chr15","-",43220725,43221051,43220815,43221051,43216267,43216453,7331,"5,0","68,56","21,30",71125,239,149,{"v":4.97745072603e-07,"d":"4.98E-07"},{"v":5.4088297889526e-06,"d":"5.41E-06"},"0.044,0.0","0.156,0.13",-0.121]
[7332,"ENSG00000137822.12","TUBGCP4","chr15","+",43401715,43403799,43401715,43401850,43404412,43404552,7332,228188,"17,23",69103,164179,298,149,0,0,"0.87,0.803","0.174,0.223",0.638]
[7333,"ENSG00000137822.12","TUBGCP4","chr15","+",43403682,43403842,43403682,43403799,43404412,43404552,7333,"10,11",208174,"24,21","15,17",192,149,0,0,"0.036,0.047","0.554,0.489",-0.48]
[7337,"ENSG00000138606.19","SHF","chr15","-",45172146,45172318,45172148,45172318,45171882,45172002,7337,"1,1","1,0","6,4","2,1",151,149,0.0515069001381,0.1545207004143,"0.497,1.0","0.747,0.798",-0.024]
[7338,"ENSG00000171763.18","SPATA5L1","chr15","+",45415586,45415809,45415586,45415779,45417268,45417399,7338,"34,29","68,64","46,37","73,68",179,149,0.351026873866,0.706916343888137,"0.294,0.274","0.344,0.312",-0.044]
[7340,"ENSG00000239900.12","ADSL","chr22","+",40346528,40346711,40346528,40346656,40353072,40353117,7340,827732,"7,1",387391,"4,0",204,149,1,1,"0.989,0.998","0.986,1.0",1E-3]
[7341,"ENSG00000239900.12","ADSL","chr22","+",40346528,40346711,40346528,40346656,40358863,40359035,7341,834731,"0,0",558587,"0,4",204,149,1,1,"1.0,1.0","1.0,0.991",0.004]
[7342,"ENSG00000239900.12","ADSL","chr22","+",40361487,40361677,40361487,40361635,40362980,40363071,7342,"31,38",19261874,"38,33",507569,191,149,{"v":2.57480148314e-10,"d":"2.57E-10"},{"v":4.63205925679266e-09,"d":"4.63E-09"},"0.012,0.016","0.055,0.043",-0.035]
[7343,"ENSG00000104164.10","BLOC1S6","chr15","+",45597879,45597996,45597879,45597891,45601233,45601407,7343,"31,25","0,0","87,89","12,12",254,149,{"v":4.99651391317e-06,"d":"5.00E-06"},{"v":4.43502447837317e-05,"d":"4.44E-05"},"1.0,1.0","0.81,0.813",0.189]
[7344,"ENSG00000104164.10","BLOC1S6","chr15","+",45597879,45597996,45597879,45597891,45603099,45603187,7344,"34,26","5,9","89,90","16,20",254,149,0.818627955379,1,"0.8,0.629","0.765,0.725",-0.03]
[7345,"ENSG00000103995.13","CEP152","chr15","-",48741600,48741704,48741630,48741704,48717017,48717169,7345,"36,33","4,2","49,69","0,2",179,149,0.0132990203106,0.050024776399103,"0.882,0.932","1.0,0.966",-0.076]
[7346,"ENSG00000103995.13","CEP152","chr15","-",48741600,48741704,48741630,48741704,48738150,48739288,7346,184145,"12,13",100112,"7,10",179,149,0.935158344724,1,"0.927,0.903","0.922,0.903",2E-3]
[7347,"ENSG00000115282.19","TTC31","chr2","+",74483321,74483563,74483321,74483410,74490024,74490473,7347,"20,25",377284,"33,30","17,22",298,149,0,0,"0.026,0.042","0.493,0.405",-0.415]
[7348,"ENSG00000115282.19","TTC31","chr2","+",74483321,74483563,74483321,74483410,74490243,74490473,7348,"11,28","4,5","64,52",130172,298,149,{"v":1.15893916686E-9,"d":"1.16E-09"},{"v":1.8890708419818E-8,"d":"1.89E-08"},"0.579,0.737","0.198,0.131",0.493]
[7349,"ENSG00000115282.19","TTC31","chr2","+",74491480,74491672,74491480,74491666,74492003,74492055,7349,152122,144176,145179,"79,84",155,149,{"v":4.94640929172e-06,"d":"4.95E-06"},{"v":4.39780753391105e-05,"d":"4.40E-05"},"0.504,0.4","0.638,0.672",-0.203]
[7350,"ENSG00000115282.19","TTC31","chr2","+",74492138,74492445,74492138,74492229,74492645,74492747,7350,237207,"0,0",126177,"14,26",298,149,{"v":4.4408920985E-16,"d":"4.44E-16"},{"v":1.43900955408623e-14,"d":"1.44E-14"},"1.0,1.0","0.818,0.773",0.205]
[7353,"ENSG00000092439.14","TRPM7","chr15","-",50578558,50578664,50578638,50578664,50575868,50575919,7353,"5,9",235285,"11,16",179204,229,149,0.00399536979987,0.0176735971657078,"0.014,0.02","0.038,0.049",-0.026]
[7355,"ENSG00000137876.9","RSL24D1","chr15","-",55192402,55192833,55192719,55192833,55190974,55191047,7355,"6,9",19461779,"5,3",20622174,298,149,1,1,"0.002,0.003","0.001,0.001",2E-3]
[7356,"ENSG00000110200.8","ANAPC15","chr11","-",72111411,72111496,72111441,72111496,72111156,72111281,7356,250228,"5,9",302339,"5,2",179,149,0.0257502552503,0.0875309948815322,"0.977,0.955","0.98,0.993",-0.02]
[7357,"ENSG00000110200.8","ANAPC15","chr11","-",72111411,72111496,72111441,72111496,72111156,72111286,7357,543500,116116,598640,77113,179,149,0.00961751537635,0.0377334903058983,"0.796,0.782","0.866,0.825",-0.056]
[7358,"ENSG00000110200.8","ANAPC15","chr11","-",72112649,72112780,72112733,72112780,72111411,72111496,7358,301313,"8,5",370444,"0,3",233,149,0.00726590321175,0.0295414160060493,"0.96,0.976","1.0,0.99",-0.027]
[7359,"ENSG00000137871.20","ZNF280D","chr15","-",56666678,56666986,56666799,56666986,56658423,56658486,7359,"41,25","0,0","58,35","0,1",270,149,1,1,"1.0,1.0","1.0,0.951",0.024]
[7360,"ENSG00000137871.20","ZNF280D","chr15","-",56666678,56666986,56666799,56666986,56666394,56666535,7360,"84,77","1,6","124,87","2,1",270,149,0.0763447598475,0.21139964067102,"0.979,0.876","0.972,0.98",-0.048]
[7361,"ENSG00000186654.20","PRR5","chr22","+",44725243,44725296,44725243,44725292,44726576,44726634,7361,"0,0",162186,"0,4",195192,153,149,1,1,"0.0,0.0","0.0,0.02",-0.01]
[7362,"ENSG00000137776.16","SLTM","chr15","-",58893820,58893987,58893901,58893987,58893278,58893364,7362,16091533,"80,84",13281280,"34,25",230,149,{"v":2.01719085535e-06,"d":"2.02E-06"},{"v":1.9728126565323e-05,"d":"1.97E-05"},"0.929,0.922","0.962,0.971",-0.041]
[7363,"ENSG00000182718.16","ANXA2","chr15","-",60352378,60352476,60352382,60352476,60351723,60351819,7363,"0,1",688662,"1,0",579547,153,149,1,1,"0.0,0.001","0.002,0.0",-1E-3]
[7364,"ENSG00000182718.16","ANXA2","chr15","-",60360930,60361054,60360940,60361054,60357145,60357236,7364,"5,1",734548,"1,2",644586,159,149,1,1,"0.006,0.002","0.001,0.003",2E-3]
[7365,"ENSG00000182718.16","ANXA2","chr15","-",60396150,60396427,60396279,60396427,60386027,60386086,7365,"9,11","0,4","5,6","0,1",278,149,0.0269522029249,0.0908370297826046,"1.0,0.596","1.0,0.763",-0.083]
[7369,"ENSG00000177830.17","CHID1","chr11","-",883147,883303,883199,883303,870418,870499,7369,299361,"5,5",261313,"4,4",201,149,0.804327491283,1,"0.978,0.982","0.98,0.983",-2E-3]
[7370,"ENSG00000177830.17","CHID1","chr11","-",883147,883303,883199,883303,882327,882515,7370,124174,"11,3",126171,"7,10",201,149,0.630657682199,1,"0.893,0.977","0.93,0.927",0.006]
[7371,"ENSG00000177830.17","CHID1","chr11","-",902147,902330,902197,902330,900935,900980,7371,"15,3",608592,"9,12",365427,199,149,0.104648234972,0.271671262506944,"0.018,0.004","0.018,0.021",-0.009]
[7372,"ENSG00000129003.17","VPS13C","chr15","-",61954420,61954554,61954466,61954554,61950944,61951024,7372,"58,31","0,0","26,28","2,0",195,149,0.519015136971,0.926886594212154,"1.0,1.0","0.909,1.0",0.045]
[7375,"ENSG00000028203.17","VEZT","chr12","+",95258244,95258287,95258244,95258282,95262905,95263081,7375,"14,3","1,2","4,0","2,0",154,149,1,1,"0.931,0.592","0.659,NA",0.103]
[7376,"ENSG00000028203.17","VEZT","chr12","+",95282312,95282644,95282312,95282359,95287663,95287857,7376,521430,"1,4",570517,"6,1",298,149,0.719493768015,1,"0.996,0.982","0.979,0.996",1E-3]
[7377,"ENSG00000028203.17","VEZT","chr12","+",95282312,95282644,95282312,95282359,95294271,95294372,7377,232168,"0,2",308255,"1,0",298,149,1,1,"1.0,0.977","0.994,1.0",-0.009]
[7379,"ENSG00000166855.9","CLPX","chr15","-",65156777,65156932,65156843,65156932,65155691,65155856,7379,"21,5",377389,"36,24",171210,215,149,{"v":7.7793205211e-10,"d":"7.78E-10"},{"v":1.2995330771117E-8,"d":"1.30E-08"},"0.037,0.009","0.127,0.073",-0.077]
[7380,"ENSG00000166855.9","CLPX","chr15","-",65158574,65158751,65158686,65158751,65157745,65157910,7380,819745,"10,13",412367,"2,10",261,149,0.849788978729,1,"0.979,0.97","0.992,0.954",1E-3]
[7381,"ENSG00000089597.17","GANAB","chr11","-",62639626,62639731,62639630,62639731,62638982,62639110,7381,"17,14","0,0","33,20","0,3",153,149,0.547100932987,0.96264035509078,"1.0,1.0","1.0,0.867",0.067]
[7382,"ENSG00000089597.17","GANAB","chr11","-",62639626,62639731,62639630,62639731,62639358,62639467,7382,16131588,"3,2",12241262,"4,15",153,149,1,1,"0.998,0.999","0.997,0.988",0.006]
[7384,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211863,68211648,68211863,68211262,68211318,7384,"82,88","6,9",191132,"2,2",242,149,{"v":5.6210024269e-05,"d":"5.62E-05"},4.0529989348921E-4,"0.894,0.858","0.983,0.976",-0.104]
[7385,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211863,68211674,68211863,68211262,68211318,7385,"104,95",770698,208161,354390,268,149,0,0,"0.07,0.07","0.246,0.187",-0.146]
[7386,"ENSG00000128973.12","CLN6","chr15","-",68211648,68211863,68211674,68211863,68211262,68211318,7386,"28,16",770698,"19,31",354390,175,149,0.000667559446738,0.00370185800412752,"0.03,0.019","0.044,0.063",-0.029]
[7387,"ENSG00000166716.9","ZNF592","chr15","+",84790704,84790883,84790704,84790872,84797868,84798045,7387,275333,"8,11",229234,"6,2",160,149,0.107780940594,0.278459980525997,"0.97,0.966","0.973,0.991",-0.014]
[7390,"ENSG00000005007.12","UPF1","chr19","+",18852986,18853104,18852986,18853071,18853251,18853350,7390,133123,405452,182115,358334,182,149,0.018083724369,0.0651086702683072,"0.212,0.182","0.294,0.22",-0.06]
[7391,"ENSG00000137831.14","UACA","chr15","-",70671964,70672001,70671970,70672001,70671038,70671091,7391,95105,"1,0","47,49","0,0",155,149,1,1,"0.989,1.0","1.0,1.0",-0.006]
[7392,"ENSG00000145020.15","AMT","chr3","-",49418970,49419405,49419259,49419405,49417817,49417973,7392,"29,28","0,0","25,26","1,1",298,149,0.765934253892,1,"1.0,1.0","0.926,0.929",0.073]
[7393,"ENSG00000145020.15","AMT","chr3","-",49418970,49420342,49419709,49420342,49417817,49417973,7393,"44,13","0,0","24,29","1,1",298,149,0.711554782765,1,"1.0,1.0","0.923,0.935",0.071]
[7394,"ENSG00000145020.15","AMT","chr3","-",49418970,49420342,49420210,49420342,49417817,49417973,7394,"43,35","1,0","33,33","0,0",298,149,1,1,"0.956,1.0","1.0,1.0",-0.022]
[7395,"ENSG00000145020.15","AMT","chr3","-",49421959,49422049,49421981,49422049,49421491,49421572,7395,"0,1","1,0","4,1","0,0",171,149,1,1,"0.0,1.0","1.0,1.0",-0.5]
[7396,"ENSG00000093000.18","NUP50","chr22","+",45170987,45171177,45170987,45171143,45171599,45171683,7396,"19,35","6,1","4,5","0,0",183,149,1.48944631892E-3,0.00755823749950064,"0.721,0.966","1.0,1.0",-0.157]
[7397,"ENSG00000171307.18","ZDHHC16","chr10","+",97455973,97456044,97455973,97456018,97456776,97457370,7397,551462,"4,2","99,41","0,0",175,149,1,1,"0.992,0.995","1.0,1.0",-0.006]
[7398,"ENSG00000125676.19","THOC2","chrX","-",123620374,123620965,123620906,123620965,123619400,123619436,7398,"55,61",742659,"27,14",378420,298,149,0.016000705368,0.0586696782994666,"0.036,0.044","0.034,0.016",0.015]
[7399,"ENSG00000125676.19","THOC2","chrX","-",123706853,123706949,123706857,123706949,123703453,123703505,7399,"2,0",441378,"0,0",139149,153,149,1,1,"0.004,0.0","0.0,0.0",2E-3]
[7400,"ENSG00000261801.5","LOXL1-AS1","chr15","-",73919837,73920038,73919959,73920038,73912184,73912303,7400,82103,"2,1","83,51","0,1",271,149,0.51023029425,0.914538071566394,"0.958,0.983","1.0,0.966",-0.013]
[7401,"ENSG00000103653.16","CSK","chr15","+",74800411,74800746,74800411,74800505,74800822,74800922,7401,12471111,"0,0",8631024,"2,2",298,149,1,1,"1.0,1.0","0.995,0.996",0.004]
[7402,"ENSG00000140474.13","ULK3","chr15","-",74837750,74837798,74837756,74837798,74837368,74837435,7402,444521,"69,92",326331,"47,67",155,149,0.839240427645,1,"0.861,0.845","0.87,0.826",0.005]
[7403,"ENSG00000140474.13","ULK3","chr15","-",74840233,74840641,74840497,74840641,74839267,74839373,7403,350365,"2,3",260221,"7,5",298,149,8.9643352143E-3,0.035494818133573,"0.989,0.984","0.949,0.957",0.033]
[7404,"ENSG00000140474.13","ULK3","chr15","-",74840233,74840641,74840497,74840641,74839557,74839713,7404,768849,"0,0",562488,"10,21",298,149,{"v":1.09377285007e-09,"d":"1.09E-09"},{"v":1.79920616529863e-08,"d":"1.80E-08"},"1.0,1.0","0.966,0.921",0.056]
[7405,"ENSG00000140474.13","ULK3","chr15","-",74842534,74842676,74842538,74842676,74842279,74842417,7405,"1,2","1,0","4,5","0,0",153,149,1,1,"0.493,1.0","1.0,1.0",-0.254]
[7406,"ENSG00000140474.13","ULK3","chr15","-",74842534,74842676,74842538,74842676,74842279,74842420,7406,"51,47","21,27","44,65","22,7",153,149,0.0862142862025,0.232804540905244,"0.703,0.629","0.661,0.9",-0.115]
[7407,"ENSG00000140474.13","ULK3","chr15","-",74842534,74842676,74842538,74842676,74842279,74842449,7407,"0,1","0,0","1,9","2,1",153,149,1,1,"NA,1.0","0.327,0.898",0.387]
[7408,"ENSG00000140497.16","SCAMP2","chr15","-",74852068,74854119,74854020,74854119,74851352,74851481,7408,747956,"0,0",717722,"1,0",298,149,1,1,"1.0,1.0","0.997,1.0",2E-3]
[7409,"ENSG00000178761.14","FAM219B","chr15","-",74906277,74906365,74906323,74906365,74905153,74905231,7409,160172,"3,17",194197,"7,6",195,149,0.110731766418,0.284716143194274,"0.976,0.885","0.955,0.962",-0.028]
[7410,"ENSG00000140400.16","MAN2C1","chr15","-",75358461,75358808,75358703,75358808,75356792,75356902,7410,"119,78","0,0",89109,"0,1",298,149,1,1,"1.0,1.0","1.0,0.982",0.009]
[7411,"ENSG00000140400.16","MAN2C1","chr15","-",75358461,75358808,75358703,75358808,75358200,75358344,7411,529522,"1,0",400466,"16,13",298,149,{"v":1.70890278595e-08,"d":"1.71E-08"},{"v":2.32713622420887E-7,"d":"2.33E-07"},"0.996,1.0","0.926,0.947",0.061]
[7413,"ENSG00000140386.12","SCAPER","chr15","-",76771723,76771954,76771741,76771954,76766917,76767088,7413,"12,8","17,20","5,16","17,12",167,149,0.697406602996,1,"0.386,0.263","0.208,0.543",-0.051]
[7414,"ENSG00000140386.12","SCAPER","chr15","-",76795240,76795440,76795279,76795440,76774854,76775117,7414,"2,0","24,18","0,0","19,18",188,149,0.316366531142,0.656027590984124,"0.062,0.0","0.0,0.0",0.031]
[7415,"ENSG00000075975.15","MKRN2","chr3","+",12568874,12569003,12568874,12568997,12570070,12570252,7415,373381,"0,3",509560,"0,0",155,149,1,1,"1.0,0.992","1.0,1.0",-0.004]
[7416,"ENSG00000140382.14","HMG20A","chr15","+",77458403,77458558,77458403,77458496,77464239,77464387,7416,"6,5",703559,"2,4",624666,211,149,1,1,"0.006,0.006","0.002,0.004",0.003]
[7420,"ENSG00000173681.16","BCLAF3","chrX","-",19937417,19937532,19937504,19937532,19935808,19935898,7420,"9,19","23,19","8,9","19,2",236,149,0.447100506277,0.83650560809182,"0.198,0.387","0.21,0.74",-0.182]
[7421,"ENSG00000255769.7","GOLGA2P10","chr15","-",82477393,82477582,82477480,82477582,82477032,82477123,7421,"31,51","1,0","18,41","0,0",236,149,1,1,"0.951,1.0","1.0,1.0",-0.024]

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[1,"ENSG00000183878.15","UTY","chrY","-",13358463,13358619,13358463,13358553,13359766,13359986,1,"14,16","0,1","4,7","3,0",215,149,1,1,"1.0,0.917","0.48,1.0",0.219]
[2,"ENSG00000067048.16","DDX3Y","chrY","+",12914883,12915227,12915066,12915227,12914563,12914649,2,582584,"1,5",624629,"22,28",298,149,{"v":2.53289711427e-09,"d":"2.53E-09"},{"v":2.96685250969507E-8,"d":"2.97E-08"},"0.997,0.983","0.934,0.918",0.064]
[3,"ENSG00000114374.12","USP9Y","chrY","+",12842224,12842465,12842239,12842465,12841009,12841133,3,"2,1","45,19","1,1","6,4",164,149,0.547486786263,0.937112057477617,"0.039,0.046","0.132,0.185",-0.116]
[10,"ENSG00000185515.14","BRCC3","chrX","+",155073373,155073431,155073376,155073431,155072326,155072343,10,"3,16",127112,"20,12","113,82",152,149,0.0225307967971,0.0727034621939106,"0.023,0.123","0.148,0.125",-0.064]
[11,"ENSG00000130830.14","MPP1","chrX","-",154786203,154786400,154786203,154786340,154789953,154790022,11,19761782,"5,5",12441239,"4,2",209,149,1,1,"0.996,0.996","0.996,0.998",-1E-3]
[12,"ENSG00000160211.17","G6PD","chrX","-",154533575,154533807,154533575,154533669,154534034,154534160,12,"5,6",579584,"8,0",326323,287,149,1,1,"0.004,0.005","0.013,0.0",-2E-3]
[13,"ENSG00000160211.17","G6PD","chrX","-",154534337,154534499,154534337,154534496,154535167,154535385,13,"57,61",730732,"43,38",378387,152,149,0.150303155855,0.354411166194346,"0.071,0.076","0.1,0.088",-0.021]
[14,"ENSG00000071889.16","FAM3A","chrX","-",154507810,154507882,154507810,154507861,154508288,154508347,14,"27,18",99111,"40,31","66,73",170,149,3.41490552244E-4,1.79239313275917E-3,"0.193,0.124","0.347,0.271",-0.15]
[15,"ENSG00000071889.16","FAM3A","chrX","-",154508473,154508652,154508473,154508597,154511847,154511871,15,"9,2",136155,"3,15",167135,204,149,0.205977322762,0.455026621647646,"0.046,0.009","0.013,0.075",-0.016]
[16,"ENSG00000071889.16","FAM3A","chrX","-",154508473,154508811,154508473,154508597,154511847,154511871,16,"20,12",136155,"9,33",167135,298,149,0.38310767471,0.729072238698501,"0.068,0.037","0.026,0.109",-0.015]
[17,"ENSG00000071889.16","FAM3A","chrX","-",154508473,154508811,154508473,154508652,154511847,154511871,17,"24,13","7,0","9,22","1,0",298,149,0.00503010219179,0.0197699703680163,"0.632,1.0","0.818,1.0",-0.093]
[18,"ENSG00000071889.16","FAM3A","chrX","-",154512313,154512431,154512313,154512411,154512822,154512936,18,"3,7","52,48","8,0","16,15",169,149,0.319242912109,0.638871011129328,"0.048,0.114","0.306,0.0",-0.072]
[19,"ENSG00000102178.12","UBL4A","chrX","-",154485770,154486083,154485770,154485979,154486227,154486333,19,"18,16",284326,"56,62",174163,253,149,0,0,"0.036,0.028","0.159,0.183",-0.139]
[20,"ENSG00000147403.16","RPL10","chrX","+",154399802,154400626,154400463,154400626,154399486,154399594,20,2523325413,"0,0",3380635926,"1,0",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[21,"ENSG00000196924.15","FLNA","chrX","-",154353000,154353221,154353000,154353204,154353295,154353457,21,"3,1",24792412,"10,16",20432184,166,149,1,1,"0.001,0.0","0.004,0.007",-0.005]
[22,"ENSG00000196924.15","FLNA","chrX","-",154365135,154365259,154365135,154365257,154365348,154365486,22,20932230,"1,0",21282103,"1,0",151,149,1,1,"1.0,1.0","1.0,1.0",0]
[23,"ENSG00000184216.13","IRAK1","chrX","-",154013042,154013433,154013042,154013343,154014041,154014278,23,545508,"56,63",416546,"15,21",239,149,{"v":7.37534593398e-08,"d":"7.38E-08"},{"v":7.20421010959907e-07,"d":"7.20E-07"},"0.859,0.834","0.945,0.942",-0.097]
[24,"ENSG00000184216.13","IRAK1","chrX","-",154013042,154013433,154013042,154013343,154016031,154016097,24,275284,"2,2",236294,"0,0",239,149,1,1,"0.988,0.989","1.0,1.0",-0.012]
[25,"ENSG00000172534.13","HCFC1","chrX","-",153951840,153952161,153951840,153952158,153952513,153952958,25,93105,752718,"79,90",632678,152,149,0.768163286509,1,"0.108,0.125","0.109,0.115",0.004]
[26,"ENSG00000172534.13","HCFC1","chrX","-",153952513,153953090,153952513,153952958,153953606,153953770,26,204228,653750,259249,802750,281,149,0.627636072459,1,"0.142,0.139","0.146,0.15",-0.007]
[27,"ENSG00000102032.12","RENBP","chrX","-",153942854,153943079,153942854,153943034,153943545,153943718,27,232186,"10,0",101121,"0,0",194,149,0.0309079560778,0.0950740651903543,"0.947,1.0","1.0,1.0",-0.026]
[28,"ENSG00000089820.15","ARHGAP4","chrX","-",153910170,153910611,153910170,153910404,153910699,153910834,28,717785,"0,1",261279,"2,0",298,149,1,1,"1.0,0.997","0.985,1.0",0.006]
[29,"ENSG00000089820.15","ARHGAP4","chrX","-",153913408,153913600,153913408,153913516,153913777,153913879,29,929966,"8,10",320371,"0,1",233,149,0.362825064327,0.701213763333444,"0.987,0.984","1.0,0.996",-0.012]
[30,"ENSG00000089820.15","ARHGAP4","chrX","-",153913408,153913600,153913408,153913516,153918831,153919053,30,484478,"3,3",208208,"0,0",233,149,1,1,"0.99,0.99","1.0,1.0",-0.01]
[31,"ENSG00000089820.15","ARHGAP4","chrX","-",153920625,153920836,153920625,153920808,153921096,153921159,31,"2,0",291289,"1,4",119182,177,149,0.711438596912,1,"0.006,0.0","0.007,0.018",-0.009]
[32,"ENSG00000089820.15","ARHGAP4","chrX","-",153921096,153921223,153921096,153921159,153921364,153921527,32,"2,1",246268,"6,21",86133,213,149,{"v":4.44607684003e-10,"d":"4.45E-10"},{"v":5.62062732231231e-09,"d":"5.62E-09"},"0.006,0.003","0.047,0.099",-0.069]
[34,"ENSG00000262919.7","CCNQ","chrX","-",153587931,153588454,153587931,153588394,153592505,153592733,34,137125,"93,85",153172,"6,8",209,149,0,0,"0.512,0.512","0.948,0.939",-0.431]
[36,"ENSG00000102181.20","CD99L2","chrX","-",150814861,150814948,150814861,150814936,150816006,150816078,36,"0,6",187194,"0,0",77105,161,149,0.692139499878,1,"0.0,0.028","0.0,0.0",0.014]
[37,"ENSG00000197021.8","CXorf40B","chrX","-",149934376,149934573,149934376,149934568,149937432,149937480,37,"6,2","0,1","9,1","0,0",154,149,1,1,"1.0,0.659","1.0,1.0",-0.17]
[38,"ENSG00000269556.7","TMEM185A","chrX","-",149608626,149608834,149608626,149608829,149611286,149611463,38,"52,72","3,1","58,60","4,15",154,149,0.00074982735526,0.00364070155572083,"0.944,0.986","0.933,0.795",0.101]
[39,"ENSG00000197620.10","CXorf40A","chrX","+",149545601,149545883,149545767,149545883,149545367,149545500,39,148186,"1,3",164209,"1,0",298,149,0.579499152967,0.970930920062829,"0.987,0.969","0.988,1.0",-0.016]
[40,"ENSG00000165359.15","INTS6L","chrX","+",135569336,135573033,135572814,135573033,135521240,135521318,40,"99,94","0,0","71,78","7,7",298,149,{"v":6.29949638786e-07,"d":"6.30E-07"},{"v":5.35812549174594e-06,"d":"5.36E-06"},"1.0,1.0","0.835,0.848",0.159]
[41,"ENSG00000165359.15","INTS6L","chrX","+",135569336,135573033,135572814,135573033,135556167,135556300,41,245249,"0,0",125103,"2,3",298,149,0.181111005627,0.411156192079034,"1.0,1.0","0.969,0.945",0.043]
[42,"ENSG00000156504.16","FAM122B","chrX","-",134769566,134772283,134769566,134771354,134781820,134781917,42,893808,"15,9",909930,"10,6",298,149,0.139506429445,0.33350441608169,"0.967,0.978","0.978,0.987",-0.01]
[43,"ENSG00000156504.16","FAM122B","chrX","-",134785885,134785950,134785885,134785947,134787471,134787533,43,371356,244216,438415,252257,152,149,0.659153497154,1,"0.598,0.618","0.63,0.613",-0.013]
[46,"ENSG00000102034.16","ELF4","chrX","-",130081255,130081539,130081255,130081312,130110619,130110716,46,268295,"0,0",234304,"10,12",298,149,{"v":2.62430489562e-07,"d":"2.62E-07"},{"v":2.35534204538708e-06,"d":"2.36E-06"},"1.0,1.0","0.921,0.927",0.076]
[49,"ENSG00000125354.22","2024-09-06","chrX","-",119625334,119625396,119625334,119625379,119629317,119629508,49,"49,25",686683,"24,28",150179,166,149,{"v":1.82547649374e-06,"d":"1.83E-06"},{"v":1.44040690414708e-05,"d":"1.44E-05"},"0.06,0.032","0.126,0.123",-0.079]
[50,"ENSG00000077713.18","SLC25A43","chrX","+",119451849,119452143,119452008,119452143,119410189,119410362,50,"13,7","32,42","7,15","8,12",298,149,0.000909437252879,0.00434194769034285,"0.169,0.077","0.304,0.385",-0.222]
[51,"ENSG00000101901.11","ALG13","chrX","+",111682131,111682294,111682235,111682294,111681169,111681424,51,167202,"19,12",156205,"3,12",253,149,0.0234721269086,0.0752026521952147,"0.838,0.908","0.968,0.91",-0.066]
[52,"ENSG00000089682.16","RBM41","chrX","-",107069254,107070425,107069254,107069402,107088435,107088839,52,"39,29","109,99","9,12","67,91",298,149,7.05144269519E-4,0.00345612377489424,"0.152,0.128","0.063,0.062",0.078]
[53,"ENSG00000123562.16","MORF4L2","chrX","-",103678498,103678620,103678498,103678600,103684680,103684729,53,165125,156179,"24,42","11,17",169,149,0.000132623675843,0.000751262393282786,"0.483,0.381","0.658,0.685",-0.239]
[54,"ENSG00000123562.16","MORF4L2","chrX","-",103678498,103678651,103678498,103678600,103684680,103684729,54,550498,156179,"92,98","11,17",200,149,0.000265934911316,0.0014182625206068,"0.724,0.675","0.862,0.811",-0.137]
[55,"ENSG00000123562.16","MORF4L2","chrX","-",103678498,103678651,103678498,103678620,103684680,103684729,55,415398,"30,25","68,68","0,12",180,149,0.875963726893,1,"0.92,0.929","1.0,0.824",0.013]
[56,"ENSG00000123562.16","MORF4L2","chrX","-",103678498,103678620,103678498,103678600,103685170,103685260,56,221133,1091976,128128,13831454,169,149,{"v":2.29907835103e-06,"d":"2.30E-06"},{"v":1.77700823008272e-05,"d":"1.78E-05"},"0.152,0.107","0.075,0.072",0.056]
[57,"ENSG00000123562.16","MORF4L2","chrX","-",103678498,103678651,103678498,103678600,103685170,103685260,57,983791,1091976,137149,13831454,200,149,0,0,"0.402,0.376","0.069,0.071",0.319]
[58,"ENSG00000123562.16","MORF4L2","chrX","-",103678498,103678651,103678498,103678620,103685170,103685260,58,848691,"86,33",113119,"104,98",180,149,0,0,"0.891,0.945","0.474,0.501",0.43]
[59,"ENSG00000166681.13","BEX3","chrX","+",103377462,103378077,103377509,103378077,103377027,103377106,59,367255,815785,643701,285364,196,149,0,0,"0.255,0.198","0.632,0.594",-0.386]
[60,"ENSG00000147206.16","NXF3","chrX","-",103078559,103078632,103078559,103078621,103079220,103079263,60,10971017,"1,4",12481391,"8,2",160,149,1,1,"0.999,0.996","0.993,0.998",2E-3]
[68,"ENSG00000101811.13","CSTF2","chrX","+",100826633,100826757,100826684,100826757,100824119,100824257,68,456439,"5,13",345336,"0,2",200,149,6.87399863861E-3,0.0260182887768109,"0.985,0.962","1.0,0.992",-0.022]
[70,"ENSG00000160219.11","GAB3","chrX","-",154713206,154713426,154713206,154713423,154716025,154716329,70,146133,"43,48",156149,"63,69",152,149,0.127069480129,0.309028504020468,"0.769,0.731","0.708,0.679",0.056]
[72,"ENSG00000147180.16","ZNF711","chrX","+",85246929,85247651,85247546,85247651,85245902,85246022,72,"63,67","38,26","17,15","21,7",298,149,0.1941345413,0.433517240011963,"0.453,0.563","0.288,0.517",0.106]
[73,"ENSG00000131174.5","COX7B","chrX","+",77902642,77902767,77902649,77902767,77901743,77901867,73,544358,"2,0",230253,"0,0",156,149,1,1,"0.996,1.0","1.0,1.0",-2E-3]
[77,"ENSG00000147099.20","HDAC8","chrX","-",72329567,72330876,72329567,72330076,72351732,72351838,77,"19,18",275209,72101,"68,39",298,149,0,0,"0.033,0.041","0.346,0.564",-0.418]
[78,"ENSG00000147099.20","HDAC8","chrX","-",72330690,72330876,72330690,72330768,72351732,72351838,78,"22,37","5,3","61,79","0,3",257,149,2.76905370041E-3,0.0117281727974975,"0.718,0.877","1.0,0.939",-0.172]
[79,"ENSG00000147099.20","HDAC8","chrX","-",72462003,72462098,72462003,72462095,72464558,72464731,79,178126,"0,0","91,71","2,0",152,149,1,1,"1.0,1.0","0.978,1.0",0.011]
[80,"ENSG00000147099.20","HDAC8","chrX","-",72462003,72462102,72462003,72462095,72464558,72464731,80,"1,3","0,0","3,5","2,0",156,149,0.544173906959,0.934140801161454,"1.0,1.0","0.589,1.0",0.206]
[81,"ENSG00000147099.20","HDAC8","chrX","-",72462003,72462102,72462003,72462098,72464558,72464731,81,"1,2",178125,"1,5","89,71",153,149,0.112556539835,0.279963352251459,"0.005,0.015","0.011,0.064",-0.027]
[82,"ENSG00000147099.20","HDAC8","chrX","-",72490928,72491006,72490928,72491000,72495155,72495268,82,241217,"2,13","52,72","1,4",155,149,0.653480688601,1,"0.991,0.941","0.98,0.945",0.004]
[84,"ENSG00000147133.15","TAF1","chrX","+",71376949,71377191,71377012,71377191,71375166,71375286,84,198211,"22,24",223210,"4,1",212,149,{"v":3.56011664593e-10,"d":"3.56E-10"},{"v":4.56322215528554e-09,"d":"4.56E-09"},"0.863,0.861","0.975,0.993",-0.122]
[85,"ENSG00000184634.15","MED12","chrX","+",71137557,71137635,71137560,71137635,71137186,71137383,85,205230,"7,8",86127,"0,2",152,149,0.0158427400426,0.0537577099727012,"0.966,0.966","1.0,0.984",-0.026]
[86,"ENSG00000184634.15","MED12","chrX","+",71137557,71137635,71137560,71137635,71137186,71137392,86,187194,"9,8",140131,"7,4",152,149,0.710852302953,1,"0.953,0.96","0.951,0.97",-0.004]
[90,"ENSG00000155659.14","VSIG4","chrX","-",66021737,66022500,66021737,66022166,66022840,66022862,90,"4,5","0,0","9,6","1,0",298,149,1,1,"1.0,1.0","0.818,1.0",0.091]
[92,"ENSG00000204271.12","SPIN3","chrX","-",56978291,56978498,56978291,56978417,56978579,56978660,92,"2,0","0,0","6,0","1,0",230,149,1,1,"1.0,NA","0.795,NA",0.205]
[93,"ENSG00000204271.12","SPIN3","chrX","-",56978291,56978498,56978291,56978421,56978579,56978660,93,"2,0","0,0","6,0","2,8",226,149,1,1,"1.0,NA","0.664,0.0",0.668]
[95,"ENSG00000204271.12","SPIN3","chrX","-",56978579,56978660,56978579,56978654,56984265,56984478,95,"6,1","0,0","9,10","0,2",155,149,0.809565324091,1,"1.0,1.0","1.0,0.828",0.086]
[99,"ENSG00000204271.12","SPIN3","chrX","-",56978579,56978747,56978579,56978660,56984265,56984478,99,"0,0","6,1","1,1","7,9",236,149,0.676485689971,1,"0.0,0.0","0.083,0.066",-0.075]
[100,"ENSG00000204271.12","SPIN3","chrX","-",56978579,56978751,56978579,56978660,56984265,56984478,100,"0,0","6,1","1,1","7,9",240,149,0.693568281811,1,"0.0,0.0","0.081,0.065",-0.073]
[101,"ENSG00000204271.12","SPIN3","chrX","-",56978579,56978762,56978579,56978660,56984265,56984478,101,"0,0","6,1","4,1","7,9",251,149,0.00485567116662,0.0192027091009917,"0.0,0.0","0.253,0.062",-0.158]
[105,"ENSG00000172943.19","PHF8","chrX","-",54042630,54042820,54042630,54042809,54043761,54044174,105,158166,"1,2","159,99","1,3",160,149,0.593207666243,0.984484926186351,"0.993,0.987","0.993,0.968",0.01]
[106,"ENSG00000172943.19","PHF8","chrX","-",54042630,54042836,54042630,54042809,54043761,54044174,106,"10,12","1,2","19,11","1,3",176,149,0.53295550387,0.925031392547909,"0.894,0.836","0.941,0.756",0.016]
[107,"ENSG00000172943.19","PHF8","chrX","-",54042630,54042836,54042630,54042820,54043761,54044174,107,"2,7",150161,"4,3","144,91",165,149,0.867134811103,1,"0.012,0.038","0.024,0.029",-2E-3]
[108,"ENSG00000172943.19","PHF8","chrX","-",54042630,54042820,54042630,54042809,54043811,54044062,108,"22,18","0,0","33,19","1,1",160,149,0.292838269044,0.597860109596723,"1.0,1.0","0.968,0.947",0.042]
[109,"ENSG00000172943.19","PHF8","chrX","-",54042630,54042820,54042630,54042809,54044874,54044949,109,"9,8","7,1","15,14","1,1",160,149,0.00818480087796,0.0302076340369035,"0.545,0.882","0.933,0.929",-0.218]
[111,"ENSG00000126012.11","KDM5C","chrX","-",53198489,53198888,53198489,53198637,53198976,53199158,111,612742,"0,0",691644,"4,4",298,149,0.812736851955,1,"1.0,1.0","0.989,0.988",0.012]
[112,"ENSG00000126012.11","KDM5C","chrX","-",53217142,53217277,53217142,53217274,53217795,53217966,112,573593,188156,604612,127130,152,149,0.0142248726716,0.0490099165208054,"0.749,0.788","0.823,0.822",-0.054]
[118,"ENSG00000269313.5","MAGIX","chrX","+",49164862,49165090,49164907,49165090,49164706,49164789,118,"2,8","4,7","3,2","2,2",194,149,0.591336242011,0.982558897014069,"0.277,0.467","0.535,0.434",-0.113]
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[199,"ENSG00000100288.19","CHKB","chr22","-",50579726,50579830,50579726,50579802,50579973,50580082,199,348290,75108,111191,"96,71",177,149,0.0153296226083,0.0522732566984506,"0.796,0.693","0.493,0.694",0.151]
[200,"ENSG00000100288.19","CHKB","chr22","-",50579726,50579830,50579726,50579802,50580189,50580271,200,"94,65","1,4","33,63","47,27",177,149,{"v":2.88183921171e-11,"d":"2.88E-11"},{"v":4.16360497956638e-10,"d":"4.16E-10"},"0.988,0.932","0.371,0.663",0.443]
[201,"ENSG00000254413.8","CHKB-CPT1B","chr22","-",50571374,50571539,50571374,50571533,50572005,50572122,201,103120,"7,6","72,89","0,3",155,149,0.0160461671791,0.0543747004375917,"0.934,0.951","1.0,0.966",-0.04]
[202,"ENSG00000254413.8","CHKB-CPT1B","chr22","-",50576535,50576637,50576535,50576593,50576856,50577034,202,178156,"7,5",118135,"2,0",193,149,0.00756041869573,0.0282808084094221,"0.952,0.96","0.979,1.0",-0.034]
[203,"ENSG00000254413.8","CHKB-CPT1B","chr22","-",50579425,50579507,50579425,50579458,50579790,50579830,203,171141,"5,0",144117,"2,0",198,149,0.827225548604,1,"0.963,1.0","0.982,1.0",-0.009]
[206,"ENSG00000025770.18","NCAPH2","chr22","+",50522497,50522569,50522500,50522569,50522342,50522415,206,"41,59",550499,"54,75",430433,152,149,0.00925823040256,0.0336452693814329,"0.068,0.104","0.11,0.145",-0.042]
[207,"ENSG00000025770.18","NCAPH2","chr22","+",50523016,50523166,50523079,50523166,50522820,50522922,207,11881336,"3,0",900885,"5,1",212,149,1,1,"0.996,1.0","0.992,0.998",0.003]
[208,"ENSG00000100253.12","MIOX","chr22","+",50488242,50488342,50488274,50488342,50487885,50488048,208,"0,6","1,0","10,1","2,0",181,149,0.645790310369,1,"0.0,1.0","0.805,1.0",-0.403]
[210,"ENSG00000100241.20","SBF1","chr22","-",50454511,50454742,50454511,50454706,50454813,50454944,210,377393,"0,0",343374,"0,3",185,149,1,1,"1.0,1.0","1.0,0.99",0.005]
[211,"ENSG00000100241.20","SBF1","chr22","-",50467531,50467693,50467531,50467690,50467785,50467923,211,"51,22",132142,"33,45",108171,152,149,0.735092393905,1,"0.275,0.132","0.23,0.205",-0.014]
[212,"ENSG00000100239.15","PPP6R2","chr22","+",50419345,50419462,50419348,50419462,50416091,50416157,212,"1,3","24,18","0,12","24,15",152,149,0.188686742744,0.424059392297016,"0.039,0.14","0.0,0.44",-0.131]
[213,"ENSG00000100239.15","PPP6R2","chr22","+",50419345,50419462,50419348,50419462,50418866,50418979,213,"15,13",301341,"7,9","95,79",152,149,0.0602140706841,0.167681426522243,"0.047,0.036","0.067,0.1",-0.042]
[214,"ENSG00000100239.15","PPP6R2","chr22","+",50439697,50439857,50439700,50439857,50438173,50438298,214,"0,4","0,1","0,1","0,0",152,149,1,1,"NA,0.797","NA,1.0",-0.203]
[215,"ENSG00000100239.15","PPP6R2","chr22","+",50439697,50439857,50439700,50439857,50438598,50438762,215,"33,42",270273,"11,9",130119,152,149,0.0291252800188,0.0903275793552387,"0.107,0.131","0.077,0.069",0.046]
[216,"ENSG00000100239.15","PPP6R2","chr22","+",50440800,50441026,50440821,50441026,50439960,50440049,216,"7,12",387358,"7,8",105129,170,149,0.0260571765083,0.0822894763074379,"0.016,0.029","0.055,0.052",-0.031]
[217,"ENSG00000100239.15","PPP6R2","chr22","+",50444198,50445090,50444202,50445090,50443865,50444117,217,402411,"12,3",157136,"4,3",153,149,0.784007456543,1,"0.97,0.993","0.975,0.978",0.005]
[218,"ENSG00000205593.11","DENND6B","chr22","-",50316565,50316712,50316565,50316626,50317292,50317373,218,"1,6","0,1","0,0","3,0",235,149,1,1,"1.0,0.792","0.0,NA",0.896]
[219,"ENSG00000196576.14","PLXNB2","chr22","-",50284131,50284244,50284131,50284213,50284572,50284665,219,"6,3",185173,"6,8",126125,180,149,0.0651735559956,0.17890906980189,"0.026,0.014","0.038,0.05",-0.024]
[220,"ENSG00000100429.17","HDAC10","chr22","-",50248224,50248472,50248224,50248292,50248661,50248751,220,168213,"0,3",153189,"5,7",298,149,0.00335345978304,0.0139190400304057,"1.0,0.973","0.939,0.931",0.051]
[221,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248890,50248830,50248859,50249102,50249168,221,125173,"18,20","60,63","8,10",180,149,0.827976269128,1,"0.852,0.877","0.861,0.839",0.015]
[222,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248890,50248830,50248859,50249327,50249454,222,"24,32","3,5","30,42","19,13",180,149,0.00586261688105,0.0225722908907174,"0.869,0.841","0.567,0.728",0.208]
[223,"ENSG00000100429.17","HDAC10","chr22","-",50249102,50249198,50249102,50249168,50249327,50249454,223,"9,8",169217,"8,10","58,31",179,149,0.000161112416491,0.000897317172572104,"0.042,0.03","0.103,0.212",-0.121]
[224,"ENSG00000100429.17","HDAC10","chr22","-",50248830,50248890,50248830,50248859,50249634,50249703,224,"22,33","0,2","30,42","0,0",180,149,0.328346255716,0.652053519792334,"1.0,0.932","1.0,1.0",-0.034]
[225,"ENSG00000100429.17","HDAC10","chr22","-",50249327,50249516,50249327,50249454,50249634,50249703,225,"28,20",218257,"39,40",217212,211,149,0.00512993379678,0.0201337155592506,"0.083,0.052","0.113,0.118",-0.048]
[226,"ENSG00000100429.17","HDAC10","chr22","-",50249634,50249719,50249634,50249703,50249859,50249964,226,"0,6",251261,"9,16",241188,165,149,{"v":5.58349676149e-05,"d":"5.58E-05"},0.000341978867378408,"0.0,0.02","0.033,0.071",-0.042]
[227,"ENSG00000170638.9","TRABD","chr22","+",50197822,50198186,50198074,50198186,50197448,50197588,227,10301142,"4,5",595683,"15,3",298,149,0.00565401392795,0.0219413839515626,"0.992,0.991","0.952,0.991",0.02]
[229,"ENSG00000182858.13","ALG12","chr22","-",49904336,49904506,49904336,49904384,49907720,49907944,229,264273,"11,8",260297,"24,29",271,149,2.35899851048E-4,0.00126868836883337,"0.93,0.949","0.856,0.849",0.087]
[230,"ENSG00000100416.13","TRMU","chr22","+",46350290,46350463,46350345,46350463,46337778,46337944,230,"68,90","1,1",266305,"8,0",204,149,0.373139263944,0.714652174569882,"0.98,0.985","0.96,1.0",2E-3]
[231,"ENSG00000100416.13","TRMU","chr22","+",46350290,46350463,46350349,46350463,46337778,46337944,231,"68,90","0,0",272314,"1,0",208,149,1,1,"1.0,1.0","0.995,1.0",2E-3]
[232,"ENSG00000100416.13","TRMU","chr22","+",46350345,46350463,46350349,46350463,46337778,46337944,232,"1,1","0,0","14,9","1,0",153,149,1,1,"1.0,1.0","0.932,1.0",0.034]
[233,"ENSG00000100416.13","TRMU","chr22","+",46350290,46350463,46350345,46350463,46346421,46346544,233,200192,132148,760829,"28,23",204,149,0,0,"0.525,0.487","0.952,0.963",-0.452]
[234,"ENSG00000100416.13","TRMU","chr22","+",46350290,46350463,46350349,46350463,46346421,46346544,234,200192,"47,76",766838,"15,13",208,149,0,0,"0.753,0.644","0.973,0.979",-0.277]
[235,"ENSG00000100416.13","TRMU","chr22","+",46350345,46350463,46350349,46350463,46346421,46346544,235,132148,"47,76","34,32","15,13",153,149,0.861095246734,1,"0.732,0.655","0.688,0.706",-0.003]
[240,"ENSG00000100227.17","POLDIP3","chr22","-",42595536,42595614,42595536,42595603,42596185,42596365,240,881757,"8,4",10231100,"4,5",160,149,1,1,"0.99,0.994","0.996,0.995",-0.004]
[241,"ENSG00000100227.17","POLDIP3","chr22","-",42601969,42602107,42601969,42602056,42602769,42603160,241,"5,14",705666,"4,5",439409,200,149,0.834316277429,1,"0.005,0.015","0.007,0.009",2E-3]
[242,"ENSG00000189306.10","RRP7A","chr22","-",42516010,42516296,42516010,42516136,42518004,42518147,242,"19,31",813799,"42,35",281278,298,149,{"v":1.87294624254E-12,"d":"1.87E-12"},{"v":3.1126940259287e-11,"d":"3.11E-11"},"0.012,0.019","0.07,0.059",-0.049]
[246,"ENSG00000196419.12","XRCC6","chr22","+",41636112,41636251,41636235,41636251,41628117,41628230,246,1372011701,"10,2",93889584,"3,7",272,149,1,1,"0.999,1.0","0.999,0.999",1E-3]
[247,"ENSG00000100401.19","RANGAP1","chr22","-",41280932,41281212,41280932,41281082,41285362,41285905,247,"39,33","4,6","72,57","7,8",279,149,0.791058846913,1,"0.839,0.746","0.846,0.792",-0.026]
[248,"ENSG00000100401.19","RANGAP1","chr22","-",41280932,41281212,41280932,41281082,41285543,41285965,248,"40,34","53,55","71,57","79,90",279,149,0.621340751035,1,"0.287,0.248","0.324,0.253",-0.021]
[249,"ENSG00000100401.19","RANGAP1","chr22","-",41280932,41281212,41280932,41281082,41285985,41286251,249,"43,37",407426,"76,61",379470,279,149,0.00299333411356,0.0125689720525332,"0.053,0.044","0.097,0.065",-0.033]
[250,"ENSG00000100395.14","L3MBTL2","chr22","+",41213850,41214026,41213892,41214026,41209695,41209933,250,"6,4",240189,"13,16",112133,191,149,{"v":4.1590412474E-6,"d":"4.16E-06"},{"v":3.11289973508016E-5,"d":"3.11E-05"},"0.019,0.016","0.083,0.086",-0.067]
[251,"ENSG00000100395.14","L3MBTL2","chr22","+",41217122,41219536,41219418,41219536,41216138,41216262,251,218251,"0,0",144155,"2,5",298,149,0.0271751594286,0.0851070986183458,"1.0,1.0","0.973,0.939",0.044]
[252,"ENSG00000100335.14","MIEF1","chr22","+",39509337,39509571,39509421,39509571,39504202,39504534,252,"14,9","7,8","12,16","3,13",233,149,0.666253146005,1,"0.561,0.418","0.719,0.44",-0.09]
[253,"ENSG00000100335.14","MIEF1","chr22","+",39512231,39512494,39512317,39512494,39511848,39512026,253,314332,126124,584491,"75,86",235,149,{"v":2.24307794561E-10,"d":"2.24E-10"},{"v":2.93868015844292e-09,"d":"2.94E-09"},"0.612,0.629","0.832,0.784",-0.188]
[254,"ENSG00000100298.15","APOBEC3H","chr22","+",39103688,39104067,39103691,39104067,39101917,39102042,254,"0,0","5,0","2,1","0,0",152,149,1,1,"0.0,NA","1.0,1.0",-1]
[255,"ENSG00000100242.15","SUN2","chr22","-",38739341,38739426,38739341,38739423,38739721,38739943,255,218188,"0,0",410464,"9,0",152,149,0.816466678199,1,"1.0,1.0","0.978,1.0",0.011]
[256,"ENSG00000100242.15","SUN2","chr22","-",38750224,38750383,38750224,38750320,38750897,38751035,256,"0,4",123147,"1,3",234275,212,149,1,1,"0.0,0.019","0.003,0.008",0.004]
[257,"ENSG00000100242.15","SUN2","chr22","-",38754641,38754706,38754641,38754690,38755762,38756000,257,"24,31","0,1",91114,"0,0",165,149,1,1,"1.0,0.966","1.0,1.0",-0.017]
[258,"ENSG00000100211.10","CBY1","chr22","+",38670766,38670989,38670883,38670989,38668016,38668132,258,"15,12","62,76","30,35","0,12",266,149,{"v":4.72489825043e-11,"d":"4.72E-11"},{"v":6.68661795065119e-10,"d":"6.69E-10"},"0.119,0.081","1.0,0.62",-0.71]
[259,"ENSG00000100201.20","DDX17","chr22","-",38487878,38492115,38487878,38488115,38493709,38493771,259,45544393,"0,0",50334695,"1,6",298,149,1,1,"1.0,1.0","1.0,0.997",2E-3]
[260,"ENSG00000100151.15","PICK1","chr22","+",38057752,38057850,38057819,38057850,38057482,38057587,260,"62,79","0,0","78,87","0,1",216,149,1,1,"1.0,1.0","1.0,0.984",0.008]
[261,"ENSG00000100151.15","PICK1","chr22","+",38073772,38074451,38074306,38074451,38072999,38073092,261,84155,"1,0",148143,"0,0",298,149,1,1,"0.977,1.0","1.0,1.0",-0.012]
[262,"ENSG00000100116.16","GCAT","chr22","+",37813276,37813609,37813462,37813609,37812886,37812988,262,"12,24",252259,"12,25","72,45",298,149,{"v":1.72313467683E-6,"d":"1.72E-06"},{"v":1.36484774354834e-05,"d":"1.36E-05"},"0.023,0.044","0.077,0.217",-0.113]
[263,"ENSG00000100097.11","LGALS1","chr22","+",37676855,37677065,37676985,37677065,37676124,37676188,263,"12,1","0,1","0,7","0,0",279,149,1,1,"1.0,0.348","NA,1.0",-0.326]
[264,"ENSG00000133466.13","C1QTNF6","chr22","-",37182151,37182735,37182151,37182582,37185217,37185455,264,"40,38","0,0","79,56","2,0",298,149,0.399988242013,0.755604212076038,"1.0,1.0","0.952,1.0",0.024]
[266,"ENSG00000100353.17","EIF3D","chr22","-",36517300,36517493,36517300,36517431,36518762,36518910,266,"53,54",28572951,"77,57",11901304,211,149,{"v":1.17057918914E-10,"d":"1.17E-10"},{"v":1.58880740025172E-9,"d":"1.59E-09"},"0.013,0.013","0.044,0.03",-0.024]
[267,"ENSG00000100342.20","APOL1","chr22","+",36254897,36254999,36254936,36254999,36253070,36253219,267,"5,0","22,11","1,0","9,30",188,149,0.0207099778656,0.0675700089985087,"0.153,0.0","0.081,0.0",0.036]
[273,"ENSG00000128284.19","APOL3","chr22","-",36149045,36149371,36149045,36149142,36160668,36160929,273,"8,14","9,8","1,2","13,10",298,149,{"v":3.73349186096E-5,"d":"3.73E-05"},2.37619708387883E-4,"0.308,0.467","0.037,0.091",0.324]
[274,"ENSG00000100320.22","RBFOX2","chr22","-",35759887,35760032,35759887,35760020,35761201,35761294,274,"23,49","34,34","44,45","33,28",161,149,0.253073949419,0.535530049127779,"0.385,0.572","0.552,0.598",-0.096]
[275,"ENSG00000100320.22","RBFOX2","chr22","-",35781599,35781746,35781599,35781743,35809779,35810004,275,"23,22","32,27","27,30","49,76",152,149,0.0649977603956,0.17860385253834,"0.413,0.444","0.351,0.279",0.113]
[276,"ENSG00000100150.17","DEPDC5","chr22","+",31758526,31758633,31758545,31758633,31754861,31754979,276,"1,0","109,96","47,38",126121,168,149,0,0,"0.008,0.0","0.249,0.218",-0.229]
[277,"ENSG00000100150.17","DEPDC5","chr22","+",31766584,31766668,31766603,31766668,31764974,31765060,277,137145,"1,4",166184,"1,1",168,149,0.663888569925,1,"0.992,0.97","0.993,0.994",-0.013]
[278,"ENSG00000100150.17","DEPDC5","chr22","+",31836971,31837155,31836998,31837155,31833914,31833980,278,"69,64","30,36","75,93","1,2",176,149,0,0,"0.661,0.601","0.984,0.975",-0.349]
[279,"ENSG00000100150.17","DEPDC5","chr22","+",31836971,31837155,31837093,31837155,31833914,31833980,279,130115,"0,9",109143,"0,1",271,149,3.10094453219E-3,0.0129639093161555,"1.0,0.875","1.0,0.987",-0.056]
[280,"ENSG00000100150.17","DEPDC5","chr22","+",31836998,31837155,31837093,31837155,31833914,31833980,280,"91,87","0,9","35,52","0,1",244,149,0.00729221165033,0.0274135590281897,"1.0,0.855","1.0,0.969",-0.057]
[281,"ENSG00000100150.17","DEPDC5","chr22","+",31873171,31873332,31873254,31873332,31870589,31870744,281,"2,1","87,66","3,2","45,62",232,149,0.363061443923,0.701369126287388,"0.015,0.01","0.041,0.02",-0.018]
[282,"ENSG00000100150.17","DEPDC5","chr22","+",31874272,31874405,31874277,31874405,31873254,31873332,282,"60,51","0,1","24,42","2,9",154,149,{"v":2.57048567682e-05,"d":"2.57E-05"},0.000169048673416877,"1.0,0.98","0.921,0.819",0.12]
[283,"ENSG00000100150.17","DEPDC5","chr22","+",31876086,31876265,31876156,31876265,31874272,31874405,283,"2,4","96,89","4,2","12,21",219,149,0.0265299790356,0.0834331119234853,"0.014,0.03","0.185,0.061",-0.101]
[284,"ENSG00000185133.13","INPP5J","chr22","+",31126293,31126489,31126375,31126489,31125832,31126010,284,"0,0","2,4","2,0","4,0",231,149,1,1,"0.0,0.0","0.244,NA",-0.244]
[287,"ENSG00000183963.18","SMTN","chr22","+",31087932,31088113,31087964,31088113,31083178,31083309,287,"2,0",135117,"2,0","65,62",181,149,1,1,"0.012,0.0","0.025,0.0",-0.007]
[288,"ENSG00000183963.18","SMTN","chr22","+",31088453,31088606,31088512,31088606,31087964,31088113,288,"13,6",130182,"9,5","55,84",208,149,0.262731570867,0.550627474652522,"0.067,0.023","0.105,0.041",-0.028]
[289,"ENSG00000183963.18","SMTN","chr22","+",31095851,31096897,31096732,31096897,31095533,31095609,289,"32,10",161168,"4,6",64103,298,149,0.0163962300158,0.0552739575288737,"0.09,0.029","0.03,0.028",0.03]
[290,"ENSG00000183963.18","SMTN","chr22","+",31096997,31097338,31097268,31097338,31096732,31096897,290,259277,"0,0",116139,"3,2",298,149,0.237221477091,0.508734861524609,"1.0,1.0","0.951,0.972",0.038]
[291,"ENSG00000183963.18","SMTN","chr22","+",31099061,31099179,31099064,31099179,31098666,31098840,291,234194,"6,6","90,76","0,0",152,149,0.0287359805669,0.0892448206418275,"0.975,0.969","1.0,1.0",-0.028]
[292,"ENSG00000183963.18","SMTN","chr22","+",31099061,31099896,31099744,31099896,31098666,31098840,292,230195,"10,0","92,84","5,7",298,149,0.0239152277715,0.0763979136783703,"0.92,1.0","0.902,0.857",0.081]
[293,"ENSG00000185339.8","TCN2","chr22","+",30612872,30613042,30612884,30613042,30610870,30611063,293,"15,7","0,1","26,30","0,0",161,149,1,1,"1.0,0.866","1.0,1.0",-0.067]
[295,"ENSG00000100003.17","SEC14L2","chr22","+",30407414,30407603,30407523,30407603,30407094,30407154,295,"0,4","0,1","6,1","0,0",258,149,1,1,"NA,0.698","1.0,1.0",-0.302]
[298,"ENSG00000248751.6","AC004997.1","chr22","-",30286015,30286142,30286015,30286098,30286824,30286948,298,"2,2","2,2","3,0","1,2",193,149,0.37690935037,0.719420135996303,"0.436,0.436","0.698,0.0",0.087]
[299,"ENSG00000248751.6","AC004997.1","chr22","-",30286824,30286951,30286824,30286948,30287154,30287287,299,"7,9","35,41","7,4","14,17",152,149,0.355854383824,0.69015444458663,"0.164,0.177","0.329,0.187",-0.088]
[300,"ENSG00000100330.15","MTMR3","chr22","+",29978424,29978531,29978441,29978531,29970975,29971062,300,"0,3",94103,"0,4",171182,166,149,1,1,"0.0,0.025","0.0,0.019",0.003]
[301,"ENSG00000186575.17","NF2","chr22","+",29671825,29671948,29671912,29671948,29668332,29668446,301,293252,"0,0",298286,"4,0",236,149,1,1,"1.0,1.0","0.979,1.0",0.01]
[302,"ENSG00000100280.16","AP1B1","chr22","-",29334264,29334410,29334264,29334350,29338989,29339133,302,17381861,59108,21062336,"41,34",209,149,{"v":2.98553315403e-09,"d":"2.99E-09"},{"v":3.45796458748195e-08,"d":"3.46E-08"},"0.955,0.925","0.973,0.98",-0.036]
[303,"ENSG00000183765.21","CHEK2","chr22","-",28695126,28695242,28695126,28695209,28695709,28695873,303,746625,"27,33",581660,"0,3",182,149,{"v":1.85721438228E-11,"d":"1.86E-11"},{"v":2.72599626057487e-10,"d":"2.73E-10"},"0.958,0.939","1.0,0.994",-0.049]
[305,"ENSG00000100099.20","HPS4","chr22","-",26465454,26466262,26465454,26465551,26468550,26468623,305,277401,"0,0",581573,"1,0",298,149,1,1,"1.0,1.0","0.997,1.0",2E-3]
[306,"ENSG00000100099.20","HPS4","chr22","-",26465454,26466262,26465454,26465551,26470718,26470813,306,"61,90","0,0",354368,"1,5",298,149,0.684460362483,1,"1.0,1.0","0.994,0.974",0.016]
[307,"ENSG00000100099.20","HPS4","chr22","-",26466225,26468623,26466225,26466262,26470718,26470813,307,383517,"2,0",610609,"26,29",298,149,{"v":3.05240277498e-11,"d":"3.05E-11"},{"v":4.40236108050593e-10,"d":"4.40E-10"},"0.99,1.0","0.921,0.913",0.078]
[308,"ENSG00000100099.20","HPS4","chr22","-",26470718,26470922,26470718,26470813,26471212,26471388,308,"26,42","64,50","69,76","28,43",258,149,{"v":4.26880316295e-06,"d":"4.27E-06"},{"v":3.1824621167979e-05,"d":"3.18E-05"},"0.19,0.327","0.587,0.505",-0.288]
[309,"ENSG00000100099.20","HPS4","chr22","-",26465454,26466262,26465454,26465551,26472301,26472418,309,"59,90","0,0",336341,"1,2",298,149,1,1,"1.0,1.0","0.994,0.988",0.009]
[310,"ENSG00000100099.20","HPS4","chr22","-",26466225,26468623,26466225,26466262,26472301,26472418,310,"57,67","0,0",251267,"8,2",298,149,0.0236853950806,0.0757804712204536,"1.0,1.0","0.94,0.985",0.038]
[311,"ENSG00000100099.20","HPS4","chr22","-",26470718,26470922,26470718,26470813,26472301,26472418,311,"41,46",322398,129108,476474,258,149,{"v":9.44126876024e-06,"d":"9.44E-06"},{"v":6.65786069971686e-05,"d":"6.66E-05"},"0.068,0.063","0.135,0.116",-0.06]
[318,"ENSG00000133454.15","MYO18B","chr22","+",25835292,25835443,25835295,25835443,25832916,25832997,318,"0,3","18,10","5,3","20,20",152,149,0.168611586127,0.387232313417671,"0.0,0.227","0.197,0.128",-0.049]
[319,"ENSG00000178026.12","LRRC75B","chr22","-",24588213,24589393,24588213,24588329,24589820,24589949,319,"4,1","1,10","4,8","8,6",298,149,0.539724494658,0.931516177772902,"0.667,0.048","0.2,0.4",0.057]
[320,"ENSG00000100031.18","GGT1","chr22","+",24609961,24610033,24609964,24610033,24607953,24608023,320,"7,5","39,22","7,2","17,38",152,149,0.866014171697,1,"0.15,0.182","0.288,0.049",-0.003]
[321,"ENSG00000100031.18","GGT1","chr22","+",24610249,24610531,24610357,24610531,24607953,24608023,321,"13,18","3,3","13,5","0,0",257,149,3.55864087036E-4,0.00185959727396946,"0.715,0.777","1.0,1.0",-0.254]
[322,"ENSG00000100031.18","GGT1","chr22","+",24610249,24610531,24610357,24610531,24609961,24610033,322,"32,26","29,27","23,11","22,36",257,149,0.122290309418,0.298895825524159,"0.39,0.358","0.377,0.15",0.11]
[323,"ENSG00000100031.18","GGT1","chr22","+",24610249,24610531,24610454,24610531,24609964,24610033,323,"53,39","0,0","46,32","0,1",298,149,1,1,"1.0,1.0","1.0,0.941",0.03]
[324,"ENSG00000100031.18","GGT1","chr22","+",24610357,24610531,24610454,24610531,24609964,24610033,324,"53,47","0,0","51,59","0,1",246,149,1,1,"1.0,1.0","1.0,0.973",0.014]
[325,"ENSG00000100031.18","GGT1","chr22","+",24610413,24610531,24610454,24610531,24610249,24610336,325,"15,5","0,0","12,17","7,1",190,149,1.48201101968E-4,0.00083042685041934,"1.0,1.0","0.573,0.93",0.248]
[326,"ENSG00000100031.18","GGT1","chr22","+",24611074,24611245,24611077,24611245,24610249,24610531,326,"44,17","3,10","33,26","9,12",152,149,0.351208575123,0.682900987923807,"0.935,0.625","0.782,0.68",0.049]
[327,"ENSG00000100031.18","GGT1","chr22","+",24627409,24627619,24627431,24627619,24623779,24623916,327,"12,13","30,65","9,13","29,49",171,149,0.915486804859,1,"0.258,0.148","0.213,0.188",0.003]
[328,"ENSG00000099998.17","GGT5","chr22","-",24225244,24225414,24225244,24225411,24225545,24225652,328,"0,2","5,15","4,0","0,2",152,149,0.0605460919332,0.168379859289747,"0.0,0.116","1.0,0.0",-0.442]
[332,"ENSG00000100207.18","TCF20","chr22","-",42168608,42168736,42168608,42168703,42169846,42169896,332,"15,29","31,27","65,55","4,4",182,149,{"v":6.71684929898e-14,"d":"6.72E-14"},{"v":1.28941738973243e-12,"d":"1.29E-12"},"0.284,0.468","0.93,0.918",-0.548]
[333,"ENSG00000186716.20","BCR","chr22","+",23309942,23310433,23310323,23310433,23309423,23309483,333,"0,4",334290,77107,119133,298,149,0,0,"0.0,0.007","0.244,0.287",-0.262]
[335,"ENSG00000101974.14","ATP11C","chrX","-",139761960,139762106,139761960,139762097,139763315,139763418,335,210144,"8,4","21,37","5,1",158,149,0.172600437413,0.394753289428022,"0.961,0.971","0.798,0.972",0.081]
[336,"ENSG00000100023.18","PPIL2","chr22","+",21695393,21695496,21695397,21695496,21694936,21695070,336,213177,"15,20",177201,"4,14",153,149,0.0297050066196,0.0918507158450196,"0.933,0.896","0.977,0.933",-0.04]
[337,"ENSG00000206140.10","TMEM191C","chr22","+",21468314,21468431,21468353,21468431,21468151,21468202,337,"7,9","2,0","0,0","3,4",188,149,{"v":2.54488541351E-10,"d":"2.54E-10"},{"v":3.31835451796201e-09,"d":"3.32E-09"},"0.735,1.0","0.0,0.0",0.867]
[341,"ENSG00000184436.11","THAP7","chr22","-",21000646,21001411,21000646,21000787,21001831,21001911,341,206193,"4,1",210251,"0,1",298,149,0.640339635641,1,"0.963,0.99","1.0,0.992",-0.02]
[345,"ENSG00000226287.8","TMEM191A","chr22","+",20703632,20704040,20703967,20704040,20703467,20703524,345,"18,14","0,2","22,22","4,0",298,149,0.261441002978,0.549121412648836,"1.0,0.778","0.733,1.0",0.022]
[346,"ENSG00000244486.8","SCARF2","chr22","-",20429224,20429355,20429224,20429340,20429535,20429653,346,"3,9","7,14","2,18","3,4",164,149,0.0474213102631,0.137121661789361,"0.28,0.369","0.377,0.803",-0.266]
[347,"ENSG00000099899.14","TRMT2A","chr22","-",20113431,20113561,20113431,20113507,20113685,20113808,347,"40,45",388447,"21,19",218169,203,149,0.947466656265,1,"0.07,0.069","0.066,0.076",-2E-3]
[348,"ENSG00000099899.14","TRMT2A","chr22","-",20114573,20114685,20114573,20114681,20114760,20114876,348,455431,"1,6",264327,"0,3",153,149,1,1,"0.998,0.986","1.0,0.991",-0.004]
[350,"ENSG00000184702.19","2024-09-05","chr22","+",19720548,19720666,19720641,19720666,19720319,19720454,350,659633,"2,3",394343,"30,63",242,149,0,0,"0.995,0.992","0.89,0.77",0.163]
[351,"ENSG00000184702.19","2024-09-05","chr22","+",19721821,19721957,19721832,19721957,19721639,19721736,351,437582,"31,32",190284,"7,16",160,149,0.261362931495,0.549121412648836,"0.929,0.944","0.962,0.943",-0.016]
[352,"ENSG00000184702.19","2024-09-05","chr22","+",19721821,19722339,19722236,19722339,19721639,19721736,352,313422,"0,1",158221,"0,0",298,149,1,1,"1.0,0.995","1.0,1.0",-2E-3]
[353,"ENSG00000070371.15","CLTCL1","chr22","-",19196265,19196656,19196265,19196415,19199733,19199841,353,"4,7","0,0","0,4","1,0",298,149,1,1,"1.0,1.0","0.0,1.0",0.5]
[357,"ENSG00000274602.4","PI4KAP1","chr22","-",18536649,18537412,18536649,18536808,18538432,18538558,357,144175,"1,3",86127,"0,4",298,149,0.701462902201,1,"0.986,0.967","1.0,0.941",0.006]
[358,"ENSG00000274602.4","PI4KAP1","chr22","-",18547245,18547421,18547245,18547373,18548010,18548118,358,"32,10","76,57","0,7","53,68",197,149,{"v":1.31243723029e-05,"d":"1.31E-05"},{"v":9.03239995916595e-05,"d":"9.03E-05"},"0.242,0.117","0.0,0.072",0.143]
[359,"ENSG00000015475.18","BID","chr22","-",17739348,17740176,17739348,17739488,17743802,17744013,359,"13,3",640665,"21,8",292303,298,149,0.00107804408379,0.00507678568249316,"0.01,0.002","0.035,0.013",-0.018]
[360,"ENSG00000099954.18","CECR2","chr22","+",17548147,17549564,17548150,17549564,17542156,17543003,360,"2,8","0,0","6,9","0,5",152,149,0.00247710606763,0.0106318612914585,"1.0,1.0","1.0,0.638",0.181]
[361,"ENSG00000160305.17","DIP2A","chr21","+",46511416,46511614,46511428,46511614,46509256,46509376,361,249366,"0,0",438424,"3,0",161,149,1,1,"1.0,1.0","0.993,1.0",0.004]
[362,"ENSG00000160298.17","C21orf58","chr21","-",46301129,46302154,46301129,46301713,46302484,46302576,362,481596,"0,3",461445,"15,12",298,149,{"v":7.16064244122e-07,"d":"7.16E-07"},{"v":6.03487883791031e-06,"d":"6.03E-06"},"1.0,0.99","0.939,0.949",0.051]
[363,"ENSG00000160298.17","C21orf58","chr21","-",46314715,46315049,46314715,46314880,46315473,46315547,363,176175,171194,160189,161180,298,149,0.681268078794,1,"0.34,0.311","0.332,0.344",-0.012]
[364,"ENSG00000160298.17","C21orf58","chr21","-",46317207,46317348,46317207,46317268,46318011,46318220,364,142146,127102,275245,"75,85",229,149,{"v":3.10912018353E-9,"d":"3.11E-09"},{"v":3.59107711448667e-08,"d":"3.59E-08"},"0.421,0.482","0.705,0.652",-0.227]
[365,"ENSG00000160294.10","MCM3AP","chr21","-",46246306,46246886,46246306,46246404,46251528,46251682,365,641542,"0,0",655652,"1,2",298,149,1,1,"1.0,1.0","0.997,0.994",0.004]
[366,"ENSG00000160294.10","MCM3AP","chr21","-",46246306,46246886,46246306,46246404,46260792,46260906,366,98110,"0,0",180169,"4,0",298,149,0.563532532241,0.954724267594405,"1.0,1.0","0.957,1.0",0.022]
[370,"ENSG00000183570.16","PCBP3","chr21","+",45929916,45929995,45929919,45929995,45917587,45917629,370,"12,11","3,2","0,1","0,0",152,149,1,1,"0.797,0.844","NA,1.0",-0.179]
[372,"ENSG00000182871.14","COL18A1","chr21","+",45505834,45505966,45505837,45505966,45505357,45505431,372,98168,683780,172162,720709,152,149,0.0489336133069,0.140953961498479,"0.123,0.174","0.19,0.183",-0.038]
[373,"ENSG00000160226.15","CFAP410","chr21","-",44330822,44330919,44330822,44330916,44331842,44332014,373,"36,21","22,34","14,15","7,36",152,149,0.748534086102,1,"0.616,0.377","0.662,0.29",0.021]
[374,"ENSG00000160226.15","CFAP410","chr21","-",44330822,44330919,44330822,44330916,44331847,44331968,374,"0,5","0,0","3,0","0,2",152,149,1,1,"NA,1.0","1.0,0.0",0.5]
[375,"ENSG00000160226.15","CFAP410","chr21","-",44333032,44333262,44333032,44333253,44335757,44335804,375,89134,"15,1","34,23","4,6",158,149,0.110865692701,0.277097404933512,"0.848,0.992","0.889,0.783",0.084]
[376,"ENSG00000141959.16","PFKL","chr21","+",44313912,44316339,44316243,44316339,44313637,44313682,376,18451873,"19,26",9771131,"23,15",298,149,0.119022200512,0.29350315457806,"0.98,0.973","0.955,0.974",0.012]
[377,"ENSG00000141959.16","PFKL","chr21","+",44325731,44326060,44325960,44326060,44325152,44325264,377,193202,14101171,234208,601586,298,149,{"v":2.88880031007E-12,"d":"2.89E-12"},{"v":4.68822328207642e-11,"d":"4.69E-11"},"0.064,0.079","0.163,0.151",-0.085]
[383,"ENSG00000160185.14","UBASH3A","chr21","+",42443153,42443418,42443311,42443418,42442451,42442596,383,"8,0","31,50","14,22","15,10",298,149,{"v":1.16574897513E-8,"d":"1.17E-08"},{"v":1.25715946043603e-07,"d":"1.26E-07"},"0.114,0.0","0.318,0.524",-0.364]
[384,"ENSG00000160183.14","TMPRSS3","chr21","-",42376540,42376686,42376540,42376683,42380116,42380212,384,"30,20","47,39","14,10","19,18",152,149,0.769910420195,1,"0.385,0.335","0.419,0.353",-0.026]
[385,"ENSG00000173276.13","ZBTB21","chr21","-",42002349,42002563,42002349,42002503,42002896,42002961,385,"4,6","1,0","10,12","0,0",209,149,1,1,"0.74,1.0","1.0,1.0",-0.13]
[387,"ENSG00000141956.13","PRDM15","chr21","-",41828165,41828333,41828165,41828281,41835436,41835524,387,109126,"5,2",204223,"2,0",201,149,0.0461991109124,0.13410193447551,"0.942,0.979","0.987,1.0",-0.033]
[388,"ENSG00000141956.13","PRDM15","chr21","-",41836467,41836649,41836467,41836589,41837933,41838063,388,124126,"0,3",226239,"0,0",209,149,0.663891281412,1,"1.0,0.968","1.0,1.0",-0.016]
[392,"ENSG00000157578.13","LCA5L","chr21","-",39422975,39423490,39422975,39423083,39428171,39428522,392,"5,3","0,2","0,4","0,0",298,149,1,1,"1.0,0.429","NA,1.0",-0.285]
[393,"ENSG00000157578.13","LCA5L","chr21","-",39429130,39429394,39429130,39429211,39435419,39435542,393,"1,0","0,0","2,0","1,0",298,149,1,1,"1.0,NA","0.5,NA",0.5]
[396,"ENSG00000157540.20","DYRK1A","chr21","+",37478180,37478300,37478207,37478300,37472683,37472880,396,"86,57",433457,226194,579512,176,149,{"v":1.05188047161e-09,"d":"1.05E-09"},{"v":1.28283011045025E-8,"d":"1.28E-08"},"0.144,0.096","0.248,0.243",-0.126]
[397,"ENSG00000157540.20","DYRK1A","chr21","+",37496090,37496258,37496117,37496258,37493016,37493163,397,"6,3",415457,"7,17",579606,176,149,0.110674668731,0.276786799694265,"0.012,0.006","0.01,0.023",-0.007]
[401,"ENSG00000159228.12","CBR1","chr21","+",36071814,36073166,36072445,36073166,36070949,36071057,401,"5,7",330362,"22,36",166196,298,149,{"v":3.49720252757e-14,"d":"3.50E-14"},{"v":6.87258307135971e-13,"d":"6.87E-13"},"0.008,0.01","0.062,0.084",-0.064]
[403,"ENSG00000237945.7","LINC00649","chr21","+",33969236,33969598,33969240,33969598,33945809,33945895,403,"39,46","3,0","64,79","0,0",153,149,0.526745891469,0.91732542586149,"0.927,1.0","1.0,1.0",-0.036]
[405,"ENSG00000159147.17","DONSON","chr21","-",33584589,33584768,33584589,33584726,33585977,33586181,405,863850,"17,5",637620,"10,8",191,149,0.815887472657,1,"0.975,0.993","0.98,0.984",2E-3]
[406,"ENSG00000159147.17","DONSON","chr21","-",33585977,33586181,33585977,33586060,33587521,33587602,406,10831163,"14,21",493523,"10,9",270,149,0.696280315901,1,"0.977,0.968","0.965,0.97",0.005]
[407,"ENSG00000159140.19","SON","chr21","+",33571734,33571788,33571750,33571788,33568970,33569087,407,"34,45","12,8","26,22","1,0",165,149,{"v":1.19823853145e-05,"d":"1.20E-05"},{"v":8.30573075306982e-05,"d":"8.31E-05"},"0.719,0.836","0.959,1.0",-0.202]
[408,"ENSG00000159140.19","SON","chr21","+",33576364,33577481,33576417,33577481,33575777,33575893,408,781727,922927,12281192,20222124,202,149,0.00221141057836,0.00959164640498926,"0.385,0.366","0.309,0.293",0.075]
[409,"ENSG00000142188.16","TMEM50B","chr21","-",33448781,33450863,33448781,33448879,33455726,33455784,409,433339,"0,2",233321,"3,6",298,149,0.0392281774396,0.116804291437236,"1.0,0.988","0.975,0.964",0.024]
[410,"ENSG00000142188.16","TMEM50B","chr21","-",33448781,33450863,33448781,33448879,33460412,33460505,410,"38,64","0,3","44,60","0,6",298,149,0.187325103836,0.421799371738242,"1.0,0.914","1.0,0.833",0.041]
[411,"ENSG00000142188.16","TMEM50B","chr21","-",33448781,33450863,33448781,33448879,33465341,33465409,411,"35,51","0,0","46,47","5,9",298,149,{"v":1.15218012586e-06,"d":"1.15E-06"},{"v":9.40455687377655e-06,"d":"9.40E-06"},"1.0,1.0","0.821,0.723",0.228]
[412,"ENSG00000156304.14","SCAF4","chr21","-",31685048,31685240,31685048,31685174,31685397,31685484,412,639710,277284,10321096,154133,215,149,0,0,"0.615,0.634","0.823,0.851",-0.212]
[413,"ENSG00000156304.14","SCAF4","chr21","-",31696568,31696750,31696568,31696736,31700994,31701171,413,754802,"0,6",782723,"1,0",163,149,1,1,"1.0,0.992","0.999,1.0",-0.004]
[414,"ENSG00000089472.16","HEPH","chrX","+",66197682,66197894,66197811,66197894,66195097,66195229,414,10881235,"21,16",787763,"5,4",278,149,0.00199786571964,0.00875240381034047,"0.965,0.976","0.988,0.99",-0.019]
[415,"ENSG00000156256.14","USP16","chr21","+",29037275,29037463,29037278,29037463,29036270,29036374,415,354344,249213,496495,315290,152,149,0.535164425097,0.926344933694306,"0.582,0.613","0.607,0.626",-0.019]
[416,"ENSG00000156256.14","USP16","chr21","+",29042471,29043599,29043422,29043599,29042012,29042104,416,536503,"0,0",617659,"7,1",298,149,0.817565336073,1,"1.0,1.0","0.978,0.997",0.012]
[417,"ENSG00000154719.13","MRPL39","chr21","-",25599798,25599866,25599798,25599836,25601367,25601467,417,787690,"18,12",159193,"5,5",179,149,0.732187719103,1,"0.973,0.98","0.964,0.97",0.009]
[419,"ENSG00000198276.15","UCKL1","chr20","-",63940949,63941208,63940949,63941043,63944396,63944458,419,"53,86","0,0","31,40","2,3",298,149,0.00404865382868,0.0163543527526757,"1.0,1.0","0.886,0.87",0.122]
[420,"ENSG00000198276.15","UCKL1","chr20","-",63940949,63941208,63940949,63941043,63944544,63944734,420,"38,61","0,1","29,36","1,1",298,149,0.43597765133,0.804887481246308,"1.0,0.968","0.935,0.947",0.043]
[421,"ENSG00000203896.9","LIME1","chr20","+",63737972,63738060,63738007,63738060,63737820,63737902,421,"16,20","28,35","25,57","60,47",184,149,0.489955075083,0.870847889448349,"0.316,0.316","0.252,0.495",-0.057]
[422,"ENSG00000203896.9","LIME1","chr20","+",63738007,63738499,63738182,63738499,63737820,63737902,422,"35,41","0,0","70,56","3,1",298,149,0.151847683286,0.357139205187407,"1.0,1.0","0.921,0.966",0.056]
[423,"ENSG00000197114.11","ZGPAT","chr20","+",63734644,63734824,63734704,63734824,63733586,63733712,423,"23,30","14,14","8,26","13,10",209,149,0.480739053427,0.859587962498946,"0.539,0.604","0.305,0.65",0.094]
[424,"ENSG00000197114.11","ZGPAT","chr20","+",63734644,63734824,63734704,63734824,63733586,63733739,424,"25,43","85,81","15,34","106,85",209,149,0.090622122195,0.235146827084835,"0.173,0.275","0.092,0.222",0.067]
[425,"ENSG00000101246.19","ARFRP1","chr20","-",63706998,63707097,63706998,63707092,63707866,63708013,425,"24,29","20,29","27,37","33,51",154,149,0.197310234136,0.439509473996735,"0.537,0.492","0.442,0.412",0.087]
[426,"ENSG00000101210.11","EEF1A2","chr20","-",63497619,63497928,63497619,63497834,63499057,63499083,426,"0,2","27,35","7,8","16,24",243,149,{"v":8.03865163845e-06,"d":"8.04E-06"},{"v":5.71297551530476e-05,"d":"5.71E-05"},"0.0,0.034","0.212,0.17",-0.174]
[433,"ENSG00000101194.17","SLC17A9","chr20","+",62966702,62968597,62967336,62968597,62966524,62966580,433,416415,"0,0",201214,"2,0",298,149,1,1,"1.0,1.0","0.98,1.0",0.01]
[434,"ENSG00000171858.17","RPS21","chr20","+",62388308,62388519,62388456,62388519,62387842,62387914,434,1768315738,"0,1",1594818535,"3,6",297,149,1,1,"1.0,1.0","1.0,0.999",0]
[435,"ENSG00000130703.16","OSBPL2","chr20","+",62259980,62260125,62260016,62260125,62256056,62256221,435,173158,"0,2",161174,"5,3",185,149,0.0917945895366,0.237446204312858,"1.0,0.985","0.963,0.979",0.021]
[436,"ENSG00000101182.14","PSMA7","chr20","-",62137363,62137465,62137363,62137426,62138170,62138290,436,"32,44",43833109,"62,40",27072790,188,149,0.0329259472384,0.100424744556105,"0.006,0.011","0.018,0.011",-0.006]
[437,"ENSG00000101158.13","NELFCD","chr20","+",58988913,58989640,58989487,58989640,58987707,58987817,437,859786,"0,0",478397,"1,0",298,149,1,1,"1.0,1.0","0.996,1.0",2E-3]
[438,"ENSG00000101158.13","NELFCD","chr20","+",58993623,58994239,58994109,58994239,58992997,58993112,438,216234,"0,1",138126,"3,4",298,149,0.0151149644666,0.0516687552850427,"1.0,0.992","0.958,0.94",0.047]
[439,"ENSG00000101158.13","NELFCD","chr20","+",58993623,58994239,58994109,58994239,58993448,58993544,439,697693,"0,0",332385,"1,0",298,149,1,1,"1.0,1.0","0.994,1.0",0.003]
[440,"ENSG00000087460.24","GNAS","chr20","+",58903527,58903585,58903530,58903585,58895611,58895684,440,32493310,16351605,40314329,23072449,152,149,0.174448535467,0.39813385515442,"0.661,0.669","0.631,0.634",0.032]
[441,"ENSG00000087460.24","GNAS","chr20","+",58903527,58903585,58903530,58903585,58898940,58898985,441,415335,18161746,255283,12001086,152,149,0.33329491484,0.65951198491246,"0.183,0.158","0.172,0.203",-0.017]
[442,"ENSG00000124222.22","STX16","chr20","+",58669290,58669453,58669301,58669453,58667986,58668127,442,434465,"1,2",236229,"2,2",160,149,1,1,"0.998,0.995","0.991,0.991",0.005]
[443,"ENSG00000124222.22","STX16","chr20","+",58671153,58671297,58671163,58671297,58670511,58670603,443,701593,"7,4",772792,"5,6",159,149,1,1,"0.989,0.993","0.993,0.992",-1E-3]
[445,"ENSG00000124224.16","PPP4R1L","chr20","-",58240514,58240710,58240514,58240610,58243511,58243705,445,"0,0","6,0","0,2","23,13",249,149,1,1,"0.0,NA","0.0,0.084",-0.042]
[449,"ENSG00000101096.19","NFATC2","chr20","-",51523080,51524110,51523080,51523596,51542369,51542719,449,"57,28","2,2","27,31","0,8",298,149,0.222453461092,0.483465933128084,"0.934,0.875","1.0,0.66",0.075]
[451,"ENSG00000101126.16","ADNP","chr20","-",50889047,50894512,50889047,50889957,50902016,50902109,451,668542,"7,6",599568,"0,1",298,149,0.094524495632,0.242991829595838,"0.979,0.978","1.0,0.996",-0.02]
[452,"ENSG00000042062.11","RIPOR3","chr20","-",50594552,50594797,50594552,50594714,50595368,50595504,452,454514,157165,584512,218260,232,149,0.0495291369673,0.142274032861038,"0.65,0.667","0.632,0.558",0.064]
[453,"ENSG00000124228.14","DDX27","chr20","+",49224774,49224991,49224944,49224991,49223267,49223433,453,"3,7",610645,"6,15",431483,298,149,0.890156114514,1,"0.002,0.005","0.007,0.015",-0.007]
[454,"ENSG00000124228.14","DDX27","chr20","+",49243628,49244077,49243815,49244077,49242593,49242681,454,582517,"0,1",509494,"0,0",298,149,1,1,"1.0,0.996","1.0,1.0",-2E-3]
[455,"ENSG00000101040.19","ZMYND8","chr20","-",47298728,47298947,47298728,47298872,47310055,47310204,455,816843,396332,12141105,"60,53",224,149,0,0,"0.578,0.628","0.931,0.933",-0.329]
[456,"ENSG00000101040.19","ZMYND8","chr20","-",47298728,47298947,47298728,47298872,47347855,47347926,456,224243,"0,2",381363,"1,2",224,149,1,1,"1.0,0.988","0.996,0.992",0]
[458,"ENSG00000158296.13","SLC13A3","chr20","-",46592403,46592529,46592403,46592446,46596156,46596342,458,"66,52","32,40","17,20","1,1",232,149,{"v":8.22677725165e-07,"d":"8.23E-07"},{"v":6.85675012542044e-06,"d":"6.86E-06"},"0.57,0.455","0.916,0.928",-0.41]
[459,"ENSG00000198185.11","ZNF334","chr20","-",46504213,46504359,46504213,46504306,46504613,46504740,459,"7,4","64,48","4,0","23,38",202,149,0.24474178641,0.521491170271873,"0.075,0.058","0.114,0.0",0.01]
[460,"ENSG00000062598.17","ELMO2","chr20","-",46368890,46370525,46368890,46368968,46371351,46371459,460,188166,"0,0",220153,"1,0",298,149,1,1,"1.0,1.0","0.991,1.0",0.004]
[461,"ENSG00000062598.17","ELMO2","chr20","-",46370442,46370525,46370442,46370513,46371351,46371459,461,187172,"4,0",214143,"0,0",161,149,0.92490635201,1,"0.977,1.0","1.0,1.0",-0.012]
[462,"ENSG00000062598.17","ELMO2","chr20","-",46368890,46370525,46368890,46368968,46371578,46371691,462,"6,4","0,0","15,18","0,1",298,149,1,1,"1.0,1.0","1.0,0.9",0.05]
[463,"ENSG00000062598.17","ELMO2","chr20","-",46387337,46387437,46387337,46387431,46389038,46389220,463,125126,"0,10",115105,"3,1",155,149,0.116609109637,0.288238255207046,"1.0,0.924","0.974,0.99",-0.02]
[464,"ENSG00000062598.17","ELMO2","chr20","-",46394404,46394532,46394404,46394503,46398696,46398771,464,"63,59","43,32","43,44","17,25",178,149,0.342097277736,0.6714823016011,"0.551,0.607","0.679,0.596",-0.058]
[465,"ENSG00000080189.14","SLC35C2","chr20","-",46355072,46355241,46355072,46355178,46355801,46355874,465,399386,"37,37",212197,"33,40",212,149,0.00174387958021,0.00777526524660297,"0.883,0.88","0.819,0.776",0.084]
[466,"ENSG00000080189.14","SLC35C2","chr20","-",46355072,46355279,46355072,46355178,46355801,46355874,466,173168,"37,37",153146,"33,40",250,149,0.574313974159,0.964712535487256,"0.736,0.73","0.734,0.685",0.023]
[467,"ENSG00000080189.14","SLC35C2","chr20","-",46355072,46355279,46355072,46355241,46355801,46355874,467,"14,27",240245,"35,42","94,93",187,149,{"v":3.3361091667e-12,"d":"3.34E-12"},{"v":5.39305132932614e-11,"d":"5.39E-11"},"0.044,0.081","0.229,0.265",-0.184]
[468,"ENSG00000080189.14","SLC35C2","chr20","-",46355072,46355279,46355072,46355178,46356573,46356637,468,165155,"7,0",142127,"0,10",250,149,0.255686917344,0.539741429469571,"0.934,1.0","1.0,0.883",0.026]
[469,"ENSG00000080189.14","SLC35C2","chr20","-",46357622,46357773,46357622,46357702,46358386,46358763,469,387455,"18,25",182185,160137,220,149,0,0,"0.936,0.925","0.435,0.478",0.474]
[470,"ENSG00000101017.13","CD40","chr20","+",46127978,46128224,46128137,46128224,46122609,46122756,470,"8,10","10,14","1,6","1,0",298,149,0.00206597631417,0.00900796086930168,"0.286,0.263","0.333,1.0",-0.392]
[471,"ENSG00000101017.13","CD40","chr20","+",46127978,46128224,46128137,46128224,46126639,46126701,471,"9,10","126,94","1,6","29,19",298,149,0.618140772479,1,"0.034,0.051","0.017,0.136",-0.034]
[472,"ENSG00000101473.16","ACOT8","chr20","-",45843526,45843772,45843526,45843721,45844262,45844420,472,"11,13",93123,"8,10","28,29",200,149,0.00750394947565,0.0281179153816339,"0.081,0.073","0.176,0.204",-0.113]
[473,"ENSG00000101473.16","ACOT8","chr20","-",45853922,45853984,45853922,45853979,45855158,45855292,473,"20,32","18,10","12,15","10,5",154,149,0.980395165087,1,"0.518,0.756","0.537,0.744",-0.004]
[476,"ENSG00000101104.12","PABPC1L","chr20","+",44930459,44930726,44930517,44930726,44924160,44924256,476,"4,1","40,26","0,1","13,32",207,149,0.0720322349127,0.195089263269438,"0.067,0.027","0.0,0.022",0.036]
[478,"ENSG00000101104.12","PABPC1L","chr20","+",44938044,44938191,44938060,44938191,44936636,44936730,478,"2,0","31,35","0,0","0,6",165,149,1,1,"0.055,0.0","NA,0.0",0.028]
[479,"ENSG00000101104.12","PABPC1L","chr20","+",44938044,44938191,44938101,44938191,44936636,44936730,479,"14,8","0,0","6,1","1,0",206,149,1,1,"1.0,1.0","0.813,1.0",0.094]
[480,"ENSG00000101104.12","PABPC1L","chr20","+",44938060,44938191,44938101,44938191,44936636,44936730,480,"43,43","0,0","6,7","1,0",190,149,1,1,"1.0,1.0","0.825,1.0",0.088]
[481,"ENSG00000166913.12","YWHAB","chr20","+",44887544,44887742,44887647,44887742,44886878,44886978,481,"3,5","0,5","10,8","0,0",252,149,0.00201457450871,0.00881628833811716,"1.0,0.372","1.0,1.0",-0.314]
[483,"ENSG00000101452.14","DHX35","chr20","+",38988792,38988917,38988812,38988917,38983698,38983776,483,"19,18","38,45","17,9","17,9",169,149,0.0227306729754,0.0732545341052042,"0.306,0.261","0.469,0.469",-0.185]
[484,"ENSG00000170471.14","RALGAPB","chr20","+",38497352,38497516,38497479,38497516,38492929,38493132,484,272186,"3,1","111,57","0,0",276,149,0.603368212125,0.996108222527872,"0.98,0.99","1.0,1.0",-0.015]
[485,"ENSG00000170471.14","RALGAPB","chr20","+",38535073,38535207,38535085,38535207,38532729,38532859,485,"79,70","17,28","69,50","5,0",161,149,{"v":5.96585624124e-07,"d":"5.97E-07"},{"v":5.09000471281927e-06,"d":"5.09E-06"},"0.811,0.698","0.927,1.0",-0.209]
[486,"ENSG00000170471.14","RALGAPB","chr20","+",38565355,38565478,38565358,38565478,38558294,38558453,486,"1,2","0,0","10,16","10,8",152,149,{"v":6.4114778132E-5,"d":"6.41E-05"},3.87821921990281E-4,"1.0,1.0","0.495,0.662",0.421]
[487,"ENSG00000170471.14","RALGAPB","chr20","+",38565355,38565478,38565358,38565478,38562531,38562697,487,"51,47","53,54","24,21","21,13",152,149,0.18948832061,0.425514931713709,"0.485,0.46","0.528,0.613",-0.098]
[488,"ENSG00000196756.11","SNHG17","chr20","-",38425934,38426052,38425934,38426048,38426418,38426503,488,"8,10","31,17","3,0","7,5",153,149,0.177876637947,0.404810910673565,"0.201,0.364","0.294,0.0",0.135]
[489,"ENSG00000196756.11","SNHG17","chr20","-",38421005,38422241,38421005,38421098,38431040,38431112,489,"74,74","0,0","18,24","4,3",298,149,{"v":9.48106326382e-06,"d":"9.48E-06"},{"v":6.68024279072721e-05,"d":"6.68E-05"},"1.0,1.0","0.692,0.8",0.254]
[490,"ENSG00000132792.18","CTNNBL1","chr20","+",37757558,37757656,37757560,37757656,37746467,37746607,490,18791836,"0,0",14811503,"2,1",151,149,1,1,"1.0,1.0","0.999,0.999",1E-3]
[491,"ENSG00000099977.14","DDT","chr22","-",23973103,23973347,23973103,23973343,23973767,23973943,491,"4,10","8,9","4,4","6,3",153,149,0.915855200361,1,"0.327,0.52","0.394,0.565",-0.056]
[492,"ENSG00000166619.13","BLCAP","chr20","-",37521318,37521451,37521318,37521409,37527792,37527878,492,"0,1","0,0","10,0","3,0",191,149,1,1,"NA,1.0","0.722,NA",0.278]
[495,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771024,36770872,36770977,36771424,36771473,495,159111,"10,13",92142,"10,8",196,149,0.727337272378,1,"0.924,0.867","0.875,0.931",-0.008]
[496,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771193,36770872,36770977,36771424,36771473,496,662476,"10,13",417445,"10,8",298,149,0.977565531636,1,"0.971,0.948","0.954,0.965",0]
[497,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771193,36770872,36771024,36771424,36771473,497,585479,"2,13",394384,"3,0",298,149,0.0197619662953,0.0649053411829397,"0.993,0.949","0.985,1.0",-0.021]
[498,"ENSG00000149636.15","DSN1","chr20","-",36770872,36771193,36770872,36770977,36773393,36773799,498,459321,"1,0",321378,"0,0",298,149,1,1,"0.996,1.0","1.0,1.0",-2E-3]
[500,"ENSG00000244462.7","RBM12","chr20","-",35658929,35659014,35658929,35658982,35664801,35664889,500,218211,"10,2","50,72","0,2",181,149,0.102151958693,0.259621879693855,"0.947,0.989","1.0,0.967",-0.016]
[502,"ENSG00000125991.19","ERGIC3","chr20","+",35542785,35542941,35542821,35542941,35542512,35542600,502,"2,6",15241699,"14,12",18451783,185,149,1,1,"0.001,0.003","0.006,0.005",-0.003]
[503,"ENSG00000125991.19","ERGIC3","chr20","+",35556876,35557109,35556954,35557109,35556206,35556271,503,"25,18","2,10","57,38","13,7",227,149,0.835861905695,1,"0.891,0.542","0.742,0.781",-0.045]
[504,"ENSG00000125991.19","ERGIC3","chr20","+",35556876,35557109,35556972,35557109,35556206,35556271,504,"38,30",15141400,"65,60",15461622,245,149,3.33649024007E-3,0.0138694303563411,"0.015,0.013","0.025,0.022",-0.01]
[505,"ENSG00000125991.19","ERGIC3","chr20","+",35556954,35557109,35556972,35557109,35556206,35556271,505,"15,22",15141400,"21,29",15461622,167,149,0.365887877252,0.704997250476495,"0.009,0.014","0.012,0.016",-0.003]
[506,"ENSG00000100991.11","TRPC4AP","chr20","-",35021189,35021356,35021189,35021332,35035122,35035308,506,219242,"97,81",146127,"85,46",173,149,0.324780771624,0.647142464939411,"0.66,0.72","0.597,0.704",0.039]
[508,"ENSG00000100983.10","GSS","chr20","-",34928472,34929237,34928472,34928951,34929400,34929590,508,217255,534574,"96,83","39,24",298,149,0,0,"0.169,0.182","0.552,0.634",-0.417]
[510,"ENSG00000100983.10","GSS","chr20","-",34945952,34946098,34945952,34946051,34951723,34951860,510,8561064,"4,5",169174,"0,1",196,149,1,1,"0.994,0.994","1.0,0.992",-2E-3]
[511,"ENSG00000101444.12","AHCY","chr20","-",34290331,34290638,34290331,34290449,34290730,34290938,511,14841487,"0,0",12631333,"0,3",298,149,1,1,"1.0,1.0","1.0,0.996",2E-3]
[513,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660003,33659884,33659998,33660258,33660395,513,"28,49","1,2","22,17","0,0",154,149,0.559860447874,0.951223661999402,"0.964,0.96","1.0,1.0",-0.038]
[514,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660034,33659884,33659998,33660258,33660395,514,"5,4","1,2","3,0","0,0",185,149,1,1,"0.801,0.617","1.0,NA",-0.291]
[515,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660058,33659884,33659998,33660258,33660395,515,"8,4","1,2","4,3","0,0",209,149,0.0586556312388,0.164057026013275,"0.851,0.588","1.0,1.0",-0.28]
[516,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660034,33659884,33660003,33660258,33660395,516,"5,4","28,49","0,0","19,17",180,149,1.58795045408E-3,0.00713760060470755,"0.129,0.063","0.0,0.0",0.096]
[517,"ENSG00000125967.16","NECAB3","chr20","-",33659884,33660058,33659884,33660003,33660258,33660395,517,"8,4","28,49","1,3","19,17",204,149,0.33580278691,0.662385386347026,"0.173,0.056","0.037,0.114",0.039]
[519,"ENSG00000125967.16","NECAB3","chr20","-",33670683,33670781,33670683,33670760,33672397,33672422,519,"4,6","0,4","4,12","0,2",170,149,0.112586251026,0.279963352251459,"1.0,0.568","1.0,0.84",-0.136]
[520,"ENSG00000125967.16","NECAB3","chr20","-",33670683,33670792,33670683,33670760,33672397,33672422,520,"87,83","0,4","35,50","0,2",181,149,0.56524117909,0.95683712965776,"1.0,0.945","1.0,0.954",-0.005]
[522,"ENSG00000078699.21","CBFA2T2","chr20","+",33640340,33640531,33640343,33640531,33636639,33636708,522,"66,71","25,14","55,51","10,22",152,149,0.911350620543,1,"0.721,0.833","0.844,0.694",0.008]
[523,"ENSG00000101391.20","CDK5RAP1","chr20","-",33366858,33367008,33366858,33367005,33370498,33370629,523,534445,"3,16",323388,"5,6",152,149,0.474001564718,0.851027273480488,"0.994,0.965","0.984,0.984",-0.004]
[528,"ENSG00000149600.11","COMMD7","chr20","-",32727892,32728025,32727892,32727995,32728088,32728142,528,"3,4",658822,"4,7",680623,179,149,1,1,"0.004,0.004","0.005,0.009",-0.003]
[530,"ENSG00000101337.15","TM9SF4","chr20","+",32141496,32141665,32141540,32141665,32133012,32133126,530,208167,"3,0",223257,"7,5",193,149,0.0307410698152,0.0947012228742398,"0.982,1.0","0.961,0.975",0.023]
[531,"ENSG00000101337.15","TM9SF4","chr20","+",32141496,32141665,32141540,32141665,32136876,32136997,531,205171,"1,1",219244,"6,7",193,149,0.00867726857437,0.0317768299441895,"0.994,0.992","0.966,0.964",0.028]
[532,"ENSG00000101336.13","HCK","chr20","+",32073715,32073818,32073718,32073818,32073318,32073361,532,"7,6","2,2","1,8","0,0",152,149,0.00335093479586,0.0139155244176599,"0.774,0.746","1.0,1.0",-0.24]
[535,"ENSG00000101294.17","HM13","chr20","+",31548964,31549114,31549028,31549114,31544946,31545035,535,"46,35",1110983,"97,73",554663,213,149,{"v":1.65423230669e-14,"d":"1.65E-14"},{"v":3.34598744375126e-13,"d":"3.35E-13"},"0.028,0.024","0.109,0.072",-0.065]
[536,"ENSG00000101294.17","HM13","chr20","+",31548638,31549114,31548964,31549114,31547447,31547692,536,"124,99","2,2",364417,"0,1",298,149,0.669712638061,1,"0.969,0.961","1.0,0.995",-0.033]
[537,"ENSG00000101294.17","HM13","chr20","+",31548638,31549114,31549028,31549114,31547447,31547692,537,"105,87","6,1",290285,"0,0",298,149,0.00412959776157,0.0166456103466116,"0.897,0.978","1.0,1.0",-0.062]
[538,"ENSG00000101294.17","HM13","chr20","+",31548964,31549114,31549028,31549114,31547447,31547692,538,"46,37","6,1","93,74","0,0",213,149,0.00071271241688,0.00348703485143707,"0.843,0.963","1.0,1.0",-0.097]
[539,"ENSG00000101294.17","HM13","chr20","+",31548638,31549114,31548964,31549114,31547464,31547606,539,"126,95","0,1",364415,"0,0",298,149,1,1,"1.0,0.979","1.0,1.0",-0.01]
[540,"ENSG00000101294.17","HM13","chr20","+",31548638,31549114,31549028,31549114,31547464,31547606,540,"107,83","13,1",290283,"0,0",298,149,{"v":2.45689340428e-07,"d":"2.46E-07"},{"v":2.2292141139709e-06,"d":"2.23E-06"},"0.805,0.976","1.0,1.0",-0.109]
[541,"ENSG00000101294.17","HM13","chr20","+",31548964,31549114,31549028,31549114,31547464,31547606,541,"44,36","13,1","93,73","0,0",213,149,{"v":1.65229365168e-06,"d":"1.65E-06"},{"v":1.31399923504372e-05,"d":"1.31E-05"},"0.703,0.962","1.0,1.0",-0.167]
[542,"ENSG00000101294.17","HM13","chr20","+",31548964,31549114,31549028,31549114,31548676,31548793,542,"46,35",101112,"93,73","20,13",213,149,0,0,"0.242,0.179","0.765,0.797",-0.571]
[543,"ENSG00000101294.17","HM13","chr20","+",31554745,31554829,31554759,31554829,31550063,31550121,543,12871214,"0,7",853907,"1,0",163,149,1,1,"1.0,0.994","0.999,1.0",-0.003]
[544,"ENSG00000130684.13","ZNF337","chr20","-",25685995,25686249,25685995,25686122,25686390,25686466,544,"8,0","57,39","4,4","38,21",276,149,0.472198117388,0.848708059709294,"0.07,0.0","0.054,0.093",-0.038]
[545,"ENSG00000197586.12","ENTPD6","chr20","+",25207075,25207397,25207078,25207397,25196153,25196254,545,"1,0","0,0","20,5","2,5",152,149,1,1,"1.0,NA","0.907,0.495",0.299]
[546,"ENSG00000197586.12","ENTPD6","chr20","+",25207075,25207397,25207078,25207397,25197104,25197226,546,"0,0","0,1","1,0","2,0",152,149,1,1,"NA,0.0","0.329,NA",-0.329]
[547,"ENSG00000197586.12","ENTPD6","chr20","+",25207075,25207397,25207078,25207397,25206521,25206590,547,"65,89","57,60","20,25","22,14",152,149,0.919019970368,1,"0.528,0.593","0.471,0.636",0.007]
[548,"ENSG00000197586.12","ENTPD6","chr20","+",25225161,25225317,25225204,25225317,25224100,25224157,548,"86,75",178137,"31,40",141158,192,149,{"v":3.80992851584e-05,"d":"3.81E-05"},0.000241188833449321,"0.273,0.298","0.146,0.164",0.13]
[550,"ENSG00000173418.11","NAA20","chr20","+",20025668,20025767,20025676,20025767,20022455,20022480,550,"4,7",732766,"0,4",578534,157,149,1,1,"0.005,0.009","0.0,0.007",0.003]
[551,"ENSG00000101310.16","SEC23B","chr20","+",18524432,18524669,18524486,18524669,18515649,18515736,551,748663,"4,2",502483,"6,1",203,149,1,1,"0.993,0.996","0.984,0.997",0.004]
[552,"ENSG00000089091.16","DZANK1","chr20","-",18412645,18412853,18412645,18412835,18414347,18414512,552,"2,4","2,0","5,5","3,3",167,149,0.0933242514457,0.240278800757277,"0.472,1.0","0.598,0.598",0.138]
[553,"ENSG00000101247.17","NDUFAF5","chr20","+",13793159,13793227,13793179,13793227,13787311,13787352,553,"12,6","0,0","43,28","5,6",169,149,0.000361264089865,0.00188543933118341,"1.0,1.0","0.883,0.804",0.156]
[554,"ENSG00000101247.17","NDUFAF5","chr20","+",13793159,13793227,13793179,13793227,13788588,13788652,554,"68,63",171138,176128,219207,169,149,0.00137704020884,0.0062756352516095,"0.26,0.287","0.415,0.353",-0.111]
[555,"ENSG00000101247.17","NDUFAF5","chr20","+",13801485,13801683,13801507,13801683,13798460,13798500,555,285232,"9,2",504430,"4,4",171,149,0.091186220573,0.236314789753715,"0.965,0.99","0.991,0.989",-0.012]
[556,"ENSG00000101384.12","JAG1","chr20","-",10648548,10648722,10648548,10648676,10649060,10649107,556,"55,67","3,2","60,61","0,0",195,149,0.0872954796929,0.227797801476784,"0.933,0.962","1.0,1.0",-0.052]
[558,"ENSG00000253352.9","TUG1","chr22","+",30972854,30973601,30972923,30973601,30972047,30972172,558,356375,"21,15",374396,"0,2",218,149,{"v":3.49035811364E-9,"d":"3.49E-09"},{"v":4.00907753966987e-08,"d":"4.01E-08"},"0.921,0.945","1.0,0.993",-0.063]
[559,"ENSG00000089057.14","SLC23A2","chr20","-",4970792,4970919,4970792,4970915,5001405,5001499,559,"27,37","8,18","27,45","6,14",153,149,0.278590128882,0.576880320588264,"0.767,0.667","0.814,0.758",-0.069]
[560,"ENSG00000101224.17","CDC25B","chr20","+",3797621,3797749,3797663,3797749,3795738,3795879,560,199172,"0,0",184214,"2,0",191,149,1,1,"1.0,1.0","0.986,1.0",0.007]
[566,"ENSG00000088833.17","NSFL1C","chr20","-",1445665,1446149,1445665,1445830,1452492,1452630,566,109109,13481264,"49,66",16111770,298,149,{"v":3.88807275264e-09,"d":"3.89E-09"},{"v":4.40488898055239E-8,"d":"4.40E-08"},"0.039,0.041","0.015,0.018",0.024]
[567,"ENSG00000088833.17","NSFL1C","chr20","-",1454966,1455132,1454966,1455037,1458199,1458274,567,21701872,"52,48",21462548,"20,45",244,149,0.0016287646843,0.00730521661811784,"0.962,0.96","0.985,0.972",-0.017]
[568,"ENSG00000088833.17","NSFL1C","chr20","-",1455713,1455870,1455713,1455719,1458199,1458274,568,"22,35","31,32","24,17","38,69",298,149,0.00731177291024,0.0274746410261079,"0.262,0.354","0.24,0.11",0.133]
[569,"ENSG00000101266.18","CSNK2A1","chr20","-",486375,487575,486375,486462,488677,488778,569,35182957,"0,0",27972891,"1,0",298,149,1,1,"1.0,1.0","0.999,1.0",0]
[570,"ENSG00000101266.18","CSNK2A1","chr20","-",487426,488778,487426,487575,489779,489881,570,27062457,"0,0",22352318,"0,2",298,149,1,1,"1.0,1.0","1.0,0.998",1E-3]
[571,"ENSG00000101266.18","CSNK2A1","chr20","-",487426,488778,487426,487575,492253,492364,571,"6,9","0,0","15,24","1,0",298,149,1,1,"1.0,1.0","0.882,1.0",0.059]
[572,"ENSG00000101266.18","CSNK2A1","chr20","-",499524,499630,499524,499573,499832,499934,572,"23,23","3,2","9,7","0,0",206,149,0.0071253471954,0.0268349247463452,"0.847,0.893","1.0,1.0",-0.13]
[574,"ENSG00000101266.18","CSNK2A1","chr20","-",500030,500171,500030,500115,505117,505229,574,"5,7","0,0","2,0","1,0",205,149,1,1,"1.0,1.0","0.592,NA",0.408]
[575,"ENSG00000101266.18","CSNK2A1","chr20","-",508450,508621,508450,508605,527932,528049,575,"35,31","4,0","34,59","0,0",165,149,0.157102171832,0.367206401071808,"0.888,1.0","1.0,1.0",-0.056]
[576,"ENSG00000101266.18","CSNK2A1","chr20","-",508450,508660,508450,508605,527932,528049,576,838831,"4,0",8711030,"0,0",204,149,1,1,"0.994,1.0","1.0,1.0",-0.003]
[577,"ENSG00000101266.18","CSNK2A1","chr20","-",508450,508660,508450,508621,527932,528049,577,803800,"0,0",837973,"0,2",188,149,1,1,"1.0,1.0","1.0,0.997",2E-3]
[578,"ENSG00000101266.18","CSNK2A1","chr20","-",508450,508660,508450,508621,543671,543727,578,13261415,"2,2",13931561,"2,1",188,149,1,1,"0.998,0.998","0.998,0.999",0]
[579,"ENSG00000130726.11","TRIM28","chr19","+",58547791,58547906,58547801,58547906,58547596,58547713,579,86778403,"0,2",59616515,"0,2",159,149,1,1,"1.0,1.0","1.0,1.0",0]
[580,"ENSG00000130726.11","TRIM28","chr19","+",58548739,58548910,58548861,58548910,58548485,58548592,580,72577714,"0,0",58196084,"1,0",271,149,1,1,"1.0,1.0","1.0,1.0",0]
[581,"ENSG00000130726.11","TRIM28","chr19","+",58548861,58548910,58548885,58548910,58548739,58548776,581,85388745,"11,23",66116736,"13,35",173,149,1,1,"0.999,0.997","0.998,0.994",2E-3]
[585,"ENSG00000171574.17","ZNF584","chr19","+",58415792,58415940,58415818,58415940,58415523,58415646,585,"10,2","7,6","2,1","0,0",175,149,{"v":2.29534457497e-06,"d":"2.30E-06"},{"v":1.77700823008272e-05,"d":"1.78E-05"},"0.549,0.221","1.0,1.0",-0.615]
[586,"ENSG00000142396.10","ERVK3-1","chr19","+",58312027,58312462,58312165,58312462,58306087,58306216,586,192149,836840,229233,522648,287,149,{"v":1.79436772663e-07,"d":"1.79E-07"},{"v":1.66264710133436E-6,"d":"1.66E-06"},"0.107,0.084","0.186,0.157",-0.076]
[587,"ENSG00000142396.10","ERVK3-1","chr19","+",58312027,58312462,58312196,58312462,58306087,58306216,587,355279,"29,22",329393,"20,17",298,149,0.0611993759842,0.169854894590686,"0.86,0.864","0.892,0.92",-0.044]
[588,"ENSG00000142396.10","ERVK3-1","chr19","+",58312165,58312462,58312196,58312462,58306087,58306216,588,1022994,"29,22",647848,"20,17",180,149,0.921387913075,1,"0.967,0.974","0.964,0.976",0]
[589,"ENSG00000142396.10","ERVK3-1","chr19","+",58312165,58312462,58312196,58312462,58312020,58312061,589,198161,"0,0",173279,"0,2",180,149,1,1,"1.0,1.0","1.0,0.991",0.004]
[590,"ENSG00000198131.13","ZNF544","chr19","+",58246710,58246794,58246745,58246794,58246300,58246427,590,295277,193206,"62,45",361397,184,149,0,0,"0.553,0.521","0.122,0.084",0.434]
[591,"ENSG00000171606.17","ZNF274","chr19","+",58185696,58185838,58185711,58185838,58183920,58183998,591,"5,4",213204,"39,28",85101,164,149,0,0,"0.021,0.018","0.294,0.201",-0.228]
[592,"ENSG00000268750.6","AC010522.1","chr19","+",57856103,57856233,57856106,57856233,57820493,57820549,592,"9,18","21,33","8,35","24,17",152,149,0.306264088603,0.618720605794075,"0.296,0.348","0.246,0.669",-0.136]
[593,"ENSG00000268750.6","AC010522.1","chr19","+",57856103,57856233,57856106,57856233,57839022,57839149,593,"10,2","4,0","0,7","0,1",152,149,1,1,"0.71,1.0","NA,0.873",-0.018]
[595,"ENSG00000188785.11","ZNF548","chr19","+",57394042,57394223,57394187,57394223,57389874,57390114,595,"8,6","75,84","12,16","96,97",294,149,0.123493712991,0.301127127854855,"0.051,0.035","0.06,0.077",-0.026]
[604,"ENSG00000131848.9","ZSCAN5A","chr19","-",56221311,56222326,56221311,56222323,56222590,56222741,604,"35,29","10,13","6,11","6,5",152,149,0.287427564731,0.589261618748115,"0.774,0.686","0.495,0.683",0.141]
[605,"ENSG00000131848.9","ZSCAN5A","chr19","-",56223630,56223834,56223630,56223795,56313282,56313384,605,"29,18","0,0","9,7","0,3",188,149,0.106167209339,0.267612360804962,"1.0,1.0","1.0,0.649",0.175]
[606,"ENSG00000063244.12","U2AF2","chr19","+",55662501,55662618,55662504,55662618,55661037,55661189,606,30963344,"0,2",30463264,"1,0",152,149,1,1,"1.0,0.999","1.0,1.0",0]
[607,"ENSG00000063244.12","U2AF2","chr19","+",55662501,55662618,55662504,55662618,55661770,55661834,607,"16,21","0,0","14,22","1,0",152,149,1,1,"1.0,1.0","0.932,1.0",0.034]
[609,"ENSG00000022556.15","NLRP2","chr19","+",54981616,54981682,54981625,54981682,54977751,54977823,609,733688,"2,4",557521,"6,10",158,149,0.320931177273,0.641321024849395,"0.997,0.994","0.989,0.98",0.011]
[615,"ENSG00000159110.19","IFNAR2","chr21","+",33241839,33241977,33241885,33241977,33230408,33230557,615,"27,32","0,3","22,46","0,2",195,149,0.685045941832,1,"1.0,0.891","1.0,0.946",-0.027]
[616,"ENSG00000170889.13","RPS9","chr19","+",54206275,54206724,54206552,54206724,54201486,54201609,616,1087010904,"4,0",1468715397,"1,1",298,149,1,1,"0.999,1.0","1.0,1.0",0]
[617,"ENSG00000170889.13","RPS9","chr19","+",54206552,54207647,54207397,54207647,54201486,54201609,617,"11,9",662735,"17,13",12561485,298,149,1,1,"0.008,0.006","0.007,0.004",2E-3]
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[632,"ENSG00000105497.7","ZNF175","chr19","+",51581367,51581517,51581390,51581517,51573327,51573401,632,"4,2",181187,"19,9",198229,172,149,0.000245547104505,0.00131375621784513,"0.019,0.009","0.077,0.033",-0.041]
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[648,"ENSG00000131408.13","NR1H2","chr19","+",50377552,50377648,50377586,50377648,50376718,50376826,648,"6,10",330301,"57,25",347405,183,149,{"v":2.45526511344e-08,"d":"2.46E-08"},{"v":2.55156811851603E-7,"d":"2.55E-07"},"0.015,0.026","0.118,0.048",-0.062]
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[653,"ENSG00000105053.10","VRK3","chr19","-",50009235,50009385,50009235,50009289,50016023,50016163,653,677567,"4,5",189201,"0,4",245,149,0.594736913096,0.986627969654956,"0.99,0.986","1.0,0.968",0.004]
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[656,"ENSG00000104960.15","PTOV1","chr19","+",49859985,49860183,49860055,49860183,49858056,49858114,656,734715,"0,0",827865,"1,1",219,149,1,1,"1.0,1.0","0.998,0.998",2E-3]
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[658,"ENSG00000104960.15","PTOV1","chr19","+",49860055,49860183,49860093,49860183,49858056,49858114,658,192200,"0,0",219255,"1,0",187,149,1,1,"1.0,1.0","0.994,1.0",0.003]
[659,"ENSG00000104960.15","PTOV1","chr19","+",49859985,49860183,49860055,49860183,49858548,49858653,659,21642055,"42,51",24292304,"17,21",219,149,{"v":1.23124408458e-06,"d":"1.23E-06"},{"v":1.00006926478177E-5,"d":"1.00E-05"},"0.972,0.965","0.99,0.987",-0.02]
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[663,"ENSG00000126453.9","BCL2L12","chr19","+",49667018,49667161,49667021,49667161,49666684,49666799,663,654726,"55,57",192200,"20,27",152,149,0.0877229972772,0.228697521666086,"0.921,0.926","0.904,0.879",0.032]
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[665,"ENSG00000142541.16","RPL13A","chr19","+",49490126,49490297,49490231,49490297,49489849,49489922,665,275255,5914261613,304339,8004591880,254,149,1,1,"0.003,0.002","0.002,0.002",1E-3]
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[669,"ENSG00000090554.12","FLT3LG","chr19","+",49478908,49479047,49478962,49479047,49476422,49476566,669,"78,68","23,24",102110,"6,6",203,149,{"v":3.06392284877e-08,"d":"3.06E-08"},{"v":3.15249530829399E-7,"d":"3.15E-07"},"0.713,0.675","0.926,0.931",-0.235]
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[673,"ENSG00000104872.10","PIH1D1","chr19","-",49446550,49446694,49446550,49446595,49447023,49447099,673,869988,"14,24",275363,"1,4",248,149,0.00649845158531,0.0247777742514831,"0.974,0.961","0.994,0.982",-0.02]
[674,"ENSG00000104872.10","PIH1D1","chr19","-",49446550,49446794,49446550,49446595,49447023,49447099,674,284401,"14,24",226254,"1,4",298,149,{"v":7.85914823964e-06,"d":"7.86E-06"},{"v":5.59930552846516e-05,"d":"5.60E-05"},"0.91,0.893","0.991,0.969",-0.079]
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[676,"ENSG00000104872.10","PIH1D1","chr19","-",49447337,49447420,49447337,49447417,49447826,49447908,676,"68,30","3,8","15,23","4,0",152,149,0.48194399247,0.86118541899455,"0.957,0.786","0.786,1.0",-0.022]
[677,"ENSG00000104872.10","PIH1D1","chr19","-",49447337,49447467,49447337,49447417,49447826,49447908,677,9921149,"3,8",359387,"4,0",199,149,1,1,"0.996,0.991","0.985,1.0",1E-3]
[678,"ENSG00000104872.10","PIH1D1","chr19","-",49447337,49447467,49447337,49447420,49447826,49447908,678,9691140,"45,21",348380,"4,16",196,149,0.486898672206,0.867422274673331,"0.942,0.976","0.985,0.948",-0.007]
[679,"ENSG00000104872.10","PIH1D1","chr19","-",49451484,49451591,49451484,49451578,49453392,49453494,679,"78,69","7,7","22,13","1,0",162,149,0.00427750377785,0.0171614365101843,"0.911,0.901","0.953,1.0",-0.07]
[680,"ENSG00000104888.9","SLC17A7","chr19","-",49432810,49433043,49432810,49432960,49433725,49433868,680,"0,0","2,0","1,0","9,2",232,149,1,1,"0.0,NA","0.067,0.0",-0.034]
[681,"ENSG00000104894.11","CD37","chr19","+",49337625,49338029,49337924,49338029,49337146,49337221,681,"14,11",498414,"9,16",655693,298,149,0.416989239566,0.780255361850369,"0.014,0.013","0.007,0.011",0.005]
[682,"ENSG00000104894.11","CD37","chr19","+",49339329,49340606,49340250,49340606,49338699,49338936,682,11721258,"6,1",12201317,110123,298,149,0,0,"0.99,0.998","0.847,0.843",0.149]
[684,"ENSG00000105443.14","CYTH2","chr19","+",48473721,48474017,48473904,48474017,48473297,48473378,684,"12,19",535549,"60,64",664570,298,149,{"v":1.97832539239e-09,"d":"1.98E-09"},{"v":2.36401332551733e-08,"d":"2.36E-08"},"0.011,0.017","0.043,0.053",-0.034]
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[705,"ENSG00000090372.14","STRN4","chr19","-",46727451,46727691,46727451,46727567,46727893,46728007,705,90131,243146,211183,226247,273,149,0.0956661570204,0.245622117699745,"0.168,0.329","0.338,0.288",-0.065]
[739,"ENSG00000076928.17","ARHGEF1","chr19","+",41903655,41903784,41903706,41903784,41903306,41903407,739,"39,64",880900,"34,34",748889,200,149,0.0790600375271,0.211021851049964,"0.032,0.05","0.033,0.028",0.011]
[748,"ENSG00000100124.14","ANKRD54","chr22","-",37838499,37838598,37838499,37838593,37840186,37840234,748,101146,"12,16",83123,"13,23",154,149,0.128305373612,0.311486084123043,"0.891,0.898","0.861,0.838",0.045]
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[801,"ENSG00000167604.14","NFKBID","chr19","-",35896725,35897058,35896725,35896831,35898471,35898532,801,"14,17","0,0","26,29","0,1",298,149,1,1,"1.0,1.0","1.0,0.935",0.032]
[828,"ENSG00000089327.14","FXYD5","chr19","+",35166141,35166325,35166250,35166325,35164155,35164245,828,40983641,"0,0",43154480,"1,0",258,149,1,1,"1.0,1.0","1.0,1.0",0]
[848,"ENSG00000167491.17","GATAD2A","chr19","+",19465339,19465614,19465344,19465614,19427695,19427992,848,"33,49","0,8","6,10","0,0",154,149,0.00358639809172,0.0147529758802747,"1.0,0.856","1.0,1.0",-0.072]
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[891,"ENSG00000011243.17","AKAP8L","chr19","-",15403474,15404042,15403474,15403555,15410519,15410594,891,11561187,"0,0",12621292,"2,2",298,149,1,1,"1.0,1.0","0.997,0.997",0.003]
[908,"ENSG00000099797.14","TECR","chr19","+",14564785,14564992,14564948,14564992,14564181,14564287,908,23242301,"0,0",16931729,"1,0",298,149,1,1,"1.0,1.0","0.999,1.0",0]
[929,"ENSG00000179262.9","RAD23A","chr19","+",12948496,12948552,12948513,12948552,12948176,12948358,929,982868,"34,11",14011380,"12,16",166,149,0.000730053704472,0.00355928005360746,"0.963,0.986","0.991,0.987",-0.015]
[948,"ENSG00000185917.13","SETD4","chr21","-",36058815,36058973,36058815,36058924,36059821,36060242,948,"30,26","0,0","43,65","0,5",198,149,0.0583501404,0.163368573375151,"1.0,1.0","1.0,0.907",0.046]
[966,"ENSG00000129351.17","ILF3","chr19","+",10684415,10685765,10684858,10685765,10683916,10683970,966,34953396,"30,36",13211299,"3,2",298,149,1.16159774044E-3,0.00540883215130203,"0.983,0.979","0.995,0.997",-0.015]
[984,"ENSG00000171469.10","ZNF561","chr19","-",9618090,9618179,9618090,9618166,9619431,9619582,984,99101,"11,7",162209,"3,9",162,149,0.00884113232844,0.0323377330785194,"0.892,0.93","0.98,0.955",-0.056]
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[1027,"ENSG00000186111.9","PIP5K1C","chr19","-",3636600,3638006,3636600,3637613,3638883,3639016,1027,"8,14","0,0","5,21","1,2",298,149,0.110170788397,0.275692923408666,"1.0,1.0","0.714,0.84",0.223]
[1048,"ENSG00000071564.14","TCF3","chr19","-",1612206,1612433,1612206,1612430,1615685,1615821,1048,224189,"38,26",123159,"24,40",152,149,0.0831651348013,0.219227102004825,"0.852,0.877","0.834,0.796",0.05]
[1063,"ENSG00000115268.9","RPS15","chr19","+",1439967,1440253,1440018,1440253,1438806,1438892,1063,"39,57",1881519802,"37,46",2271822183,200,149,1,1,"0.002,0.002","0.001,0.002",1E-3]
[1081,"ENSG00000099625.13","CBARP","chr19","-",1234190,1234331,1234190,1234290,1234570,1234742,1081,"2,5","0,3","14,30","5,5",190,149,0.906093321102,1,"1.0,0.567","0.687,0.825",0.027]
[1103,"ENSG00000157625.15","TAB3","chrX","-",30842965,30846644,30842965,30843049,30852777,30852938,1103,212236,"5,11",281191,"0,3",298,149,0.000428455581232,0.00220420727987405,"0.955,0.915","1.0,0.97",-0.05]
[1122,"ENSG00000176225.13","RTTN","chr18","-",70168854,70169067,70168854,70168973,70176674,70176845,1122,"64,60","3,7","51,30","18,18",243,149,{"v":5.56937842455e-06,"d":"5.57E-06"},{"v":4.08011088999939e-05,"d":"4.08E-05"},"0.929,0.84","0.635,0.505",0.315]
[1148,"ENSG00000141644.17","MBD1","chr18","-",50274185,50274353,50274185,50274350,50275128,50275245,1148,"1,0","0,0","9,22","3,0",152,149,1,1,"1.0,NA","0.746,1.0",0.127]
[1155,"ENSG00000152234.15","ATP5F1A","chr18","-",46095052,46095131,46095052,46095123,46097835,46098353,1155,579749,"0,3",402407,"0,0",157,149,1,1,"1.0,0.996","1.0,1.0",-2E-3]
[1201,"ENSG00000132199.19","ENOSF1","chr18","-",690548,690745,690548,690631,691067,691106,1201,"13,13",112130,"5,18","10,10",263,149,{"v":7.36834657133e-06,"d":"7.37E-06"},{"v":5.281391366987e-05,"d":"5.28E-05"},"0.062,0.054","0.221,0.505",-0.305]
[1218,"ENSG00000169718.17","DUS1L","chr17","-",82058340,82058416,82058340,82058408,82058780,82058818,1218,818853,117127,460434,"63,60",157,149,0.673410509755,1,"0.869,0.864","0.874,0.873",-0.007]
[1227,"ENSG00000185624.14","P4HB","chr17","-",81855452,81855586,81855452,81855505,81859180,81859387,1227,57385795,"43,50",42044498,"16,17",230,149,0.224453252966,0.48612975368165,"0.989,0.987","0.994,0.994",-0.006]
[1278,"ENSG00000161526.14","SAP30BP","chr17","+",75705610,75706092,75706007,75706092,75704755,75704814,1278,125126,665711,"31,64",467516,298,149,{"v":4.35643994354e-05,"d":"4.36E-05"},0.000272663822277563,"0.086,0.081","0.032,0.058",0.038]
[1298,"ENSG00000177728.16","TMEM94","chr17","+",75485870,75486426,75486289,75486426,75485427,75485547,1298,134168,"0,2",168170,"13,22",298,149,{"v":2.83490353414e-09,"d":"2.83E-09"},{"v":3.3112471843131e-08,"d":"3.31E-08"},"1.0,0.977","0.866,0.794",0.158]
[1308,"ENSG00000125447.17","GGA3","chr17","-",75240341,75241057,75240341,75240412,75241614,75241696,1308,98108,"1,4","103,64","1,0",298,149,0.0856422086536,0.224495571644577,"0.98,0.931","0.981,1.0",-0.035]
[1344,"ENSG00000256525.6","POLG2","chr17","-",64482918,64482999,64482918,64482974,64485727,64485868,1344,177172,"8,4",136108,"9,1",174,149,0.79855700981,1,"0.95,0.974","0.928,0.989",0.003]
[1365,"ENSG00000146872.17","TLK2","chr17","+",62481120,62481206,62481123,62481206,62479024,62479290,1365,"38,70","32,43",65109,"66,78",152,149,0.424410296031,0.790041433217751,"0.538,0.615","0.491,0.578",0.042]
[1383,"ENSG00000153944.10","MSI2","chr17","+",57674917,57675126,57674971,57675126,57627228,57627303,1383,"52,45","2,0",107123,"0,0",203,149,0.427127960898,0.793142001730209,"0.95,1.0","1.0,1.0",-0.025]
[1409,"ENSG00000105520.10","PLPPR2","chr19","+",11357618,11357739,11357659,11357739,11356801,11356976,1409,"0,0","8,10","0,7","13,17",190,149,0.00100806080005,0.00476616203809273,"0.0,0.0","0.0,0.244",-0.122]
[1424,"ENSG00000141295.13","SCRN2","chr17","-",47839443,47839858,47839443,47839643,47840190,47840372,1424,"37,39",182179,"37,44",125142,298,149,0.076544870649,0.205499065164181,"0.092,0.098","0.129,0.134",-0.037]
[1444,"ENSG00000030582.17","GRN","chr17","+",44349624,44349751,44349666,44349751,44349425,44349551,1444,"4,9",370436,"11,17",715773,191,149,0.536385926909,0.92749242931335,"0.008,0.016","0.012,0.017",-0.003]
[1467,"ENSG00000266967.6","AARSD1","chr17","-",42956403,42956560,42956403,42956504,42957137,42957195,1467,706754,"29,35",230291,"2,0",205,149,{"v":1.91561204899e-07,"d":"1.92E-07"},{"v":1.76317100136227e-06,"d":"1.76E-06"},"0.947,0.94","0.988,1.0",-0.05]
[1469,"ENSG00000131471.6","AOC3","chr17","+",42854275,42854733,42854536,42854733,42852752,42852943,1469,"7,1","0,0","39,43","0,2",298,149,0.456976301255,0.830165271918447,"1.0,1.0","1.0,0.915",0.042]
[1505,"ENSG00000141736.13","ERBB2","chr17","+",39694680,39695181,39694987,39695181,39693260,39693325,1505,"9,20","20,31","4,7","20,9",298,149,0.309812097623,0.624215676770539,"0.184,0.244","0.091,0.28",0.028]
[1506,"ENSG00000131748.15","STARD3","chr17","+",39656909,39657085,39657007,39657085,39653480,39653750,1506,"3,4",243290,"7,11",317320,247,149,0.167499086893,0.385210739768066,"0.007,0.008","0.013,0.02",-0.009]
[1524,"ENSG00000278259.4","MYO19","chr17","-",36501851,36501961,36501851,36501901,36503096,36503200,1524,"47,46","9,2","5,15","3,1",209,149,0.743178479911,1,"0.788,0.943","0.543,0.914",0.137]
[1567,"ENSG00000108666.9","C17orf75","chr17","-",32339812,32339938,32339812,32339924,32341203,32341284,1567,"56,39","7,7","63,74","1,0",163,149,{"v":4.2343020551e-06,"d":"4.23E-06"},{"v":3.16637213191562e-05,"d":"3.17E-05"},"0.88,0.836","0.983,1.0",-0.134]
[1588,"ENSG00000109113.19","RAB34","chr17","-",28715992,28716061,28715992,28716058,28716902,28716994,1588,"20,9",179169,"3,10","85,92",152,149,0.539500721335,0.931516177772902,"0.099,0.05","0.033,0.096",0.01]
[1609,"ENSG00000087095.12","NLK","chr17","+",28194581,28196381,28196179,28196381,28192119,28192213,1609,11571039,"1,0",16651854,"0,0",298,149,1,1,"0.998,1.0","1.0,1.0",-1E-3]
[1640,"ENSG00000108591.9","DRG2","chr17","+",18099632,18100435,18100362,18100435,18099016,18099077,1640,356403,"5,3",196131,"3,15",298,149,0.000176566221055,0.000974875946211128,"0.973,0.985","0.97,0.814",0.087]
[1654,"ENSG00000175061.17","LRRC75A-AS1","chr17","+",16440110,16440253,16440184,16440253,16439326,16439414,1654,251224,41123634,321292,982011627,223,149,{"v":1.64847135942e-10,"d":"1.65E-10"},{"v":2.18382955010703e-09,"d":"2.18E-09"},"0.039,0.04","0.021,0.017",0.02]
[1671,"ENSG00000006744.18","ELAC2","chr17","-",13004988,13005110,13004988,13005101,13005752,13005825,1671,"0,2",557543,"5,0",131152,158,149,0.628222666153,1,"0.0,0.003","0.035,0.0",-0.016]
[1695,"ENSG00000170037.13","CNTROB","chr17","+",7948486,7949137,7949084,7949137,7948156,7948327,1695,175151,"0,0",176229,"1,0",298,149,1,1,"1.0,1.0","0.989,1.0",0.006]
[1710,"ENSG00000161960.14","EIF4A1","chr17","+",7577343,7577487,7577433,7577487,7577055,7577165,1710,1895418331,175174,1303313630,79112,239,149,0.0459661130886,0.133565863995711,"0.985,0.985","0.99,0.987",-0.003]
[1728,"ENSG00000072778.19","ACADVL","chr17","+",7224714,7224884,7224808,7224884,7224479,7224552,1728,"46,48","0,0",145138,"11,16",243,149,{"v":4.27116886048E-6,"d":"4.27E-06"},{"v":3.1824621167979e-05,"d":"3.18E-05"},"1.0,1.0","0.89,0.841",0.135]
[1758,"ENSG00000142507.9","PSMB6","chr17","+",4797681,4797811,4797716,4797811,4797437,4797569,1758,27092964,"4,7",28303215,"19,13",184,149,1,1,"0.998,0.997","0.992,0.995",0.004]
[1771,"ENSG00000132361.16","CLUH","chr17","-",2700677,2700825,2700677,2700782,2701139,2701265,1771,831897,"14,5",775902,"47,38",192,149,{"v":3.41734640585e-10,"d":"3.42E-10"},{"v":4.38700522348514e-09,"d":"4.39E-09"},"0.979,0.993","0.928,0.949",0.047]
[1789,"ENSG00000140995.16","DEF8","chr16","+",89949416,89949513,89949419,89949513,89948754,89948814,1789,"25,10","7,20","10,15","1,8",152,149,0.196265859642,0.437535691938469,"0.778,0.329","0.907,0.648",-0.224]
[1816,"ENSG00000197912.15","SPG7","chr16","+",89541152,89542279,89541201,89542279,89540943,89541027,1816,"69,96","0,0","56,40","2,2",198,149,0.215100146177,0.471453105080826,"1.0,1.0","0.955,0.938",0.054]
[1825,"ENSG00000197912.15","SPG7","chr16","+",89553738,89553960,89553793,89553960,89552978,89553135,1825,"12,5",415425,"29,25",212209,204,149,{"v":1.86149984316E-11,"d":"1.86E-11"},{"v":2.72745904581729e-10,"d":"2.73E-10"},"0.021,0.009","0.091,0.08",-0.07]
[1842,"ENSG00000167508.11","MVD","chr16","-",88656104,88656561,88656104,88656304,88657435,88657582,1842,"45,31",289291,"39,55",162207,298,149,0.000674524358748,0.00331781168866972,"0.072,0.051","0.107,0.117",-0.051]
[1859,"ENSG00000170100.13","ZNF778","chr16","+",89220996,89221152,89221003,89221152,89217709,89217910,1859,"20,24","8,10","28,39","1,8",156,149,0.0108038111382,0.0385359164598247,"0.705,0.696","0.964,0.823",-0.193]
[1888,"ENSG00000141076.17","UTP4","chr16","+",69136678,69136887,69136695,69136887,69133511,69133618,1888,"40,30",1021914,"16,12",217261,166,149,0.0944925637122,0.242991829595838,"0.034,0.029","0.062,0.04",-0.02]
[1913,"ENSG00000135723.13","FHOD1","chr16","-",67236556,67236733,67236556,67236725,67236965,67237114,1913,651642,"4,0",529516,"2,0",157,149,1,1,"0.994,1.0","0.996,1.0",-1E-3]
[1928,"ENSG00000159593.14","NAE1","chr16","-",66823226,66823306,66823226,66823262,66823528,66823600,1928,745689,"15,2",310348,"0,1",193,149,0.33449573878,0.660941901763769,"0.975,0.996","1.0,0.996",-0.012]
[1955,"ENSG00000051108.14","HERPUD1","chr16","+",56939894,56940245,56940176,56940245,56936723,56936817,1955,320278,"0,0",262215,"0,5",298,149,0.735214077582,1,"1.0,1.0","1.0,0.956",0.022]
[1978,"ENSG00000100425.18","BRD1","chr22","-",49787389,49787522,49787389,49787494,49794033,49794294,1978,"10,16",190119,"17,11",129155,177,149,0.616577636703,1,"0.042,0.102","0.1,0.056",-0.006]
[1991,"ENSG00000099385.11","BCL7C","chr16","-",30892585,30892747,30892585,30892714,30893211,30893290,1991,127132,"10,6",114146,"0,0",182,149,{"v":1.62969751749E-5,"d":"1.63E-05"},1.09878711484102E-4,"0.912,0.947","1.0,1.0",-0.071]
[2018,"ENSG00000178188.14","SH2B1","chr16","+",28869207,28869383,28869276,28869383,28869005,28869097,2018,439611,"1,1",716837,"21,8",218,149,0.000511350801828,2.59207347161345E-3,"0.997,0.998","0.959,0.986",0.025]
[2033,"ENSG00000168488.18","ATXN2L","chr16","+",28836727,28837237,28836747,28837237,28835932,28836122,2033,309269,"11,17",401526,"3,3",169,149,{"v":6.14189556547e-07,"d":"6.14E-07"},{"v":5.22943941729391e-06,"d":"5.23E-06"},"0.961,0.933","0.992,0.994",-0.046]
[2049,"ENSG00000140750.16","ARHGAP17","chr16","-",24968660,24968772,24968660,24968768,24978965,24979005,2049,"11,5","0,0","7,3","1,0",153,149,1,1,"1.0,1.0","0.872,1.0",0.064]
[2075,"ENSG00000179583.19","CIITA","chr16","+",10898921,10899002,10898924,10899002,10898669,10898732,2075,"15,17","18,17","34,24","24,24",152,149,0.386644683096,0.734615162172676,"0.45,0.495","0.581,0.495",-0.066]
[2098,"ENSG00000140632.16","GLYR1","chr16","-",4813736,4813955,4813736,4813838,4814536,4814629,2098,"45,63",720782,130154,409435,266,149,0,0,"0.034,0.043","0.151,0.165",-0.119]
[2118,"ENSG00000010539.11","ZNF200","chr16","-",3232420,3232547,3232420,3232544,3232832,3232921,2118,119121,"2,1",151153,"8,4",152,149,0.021119856655,0.0687711537098802,"0.983,0.992","0.949,0.974",0.026]
[2134,"ENSG00000215301.10","DDX3X","chrX","+",41343736,41344128,41344029,41344128,41341483,41342653,2134,"66,73","0,0",153143,"0,1",298,149,1,1,"1.0,1.0","1.0,0.986",0.007]
[2151,"ENSG00000131653.12","TRAF7","chr16","+",2165856,2165936,2165878,2165936,2163882,2164001,2151,"17,5",437536,"17,28",340355,171,149,0.000108121308758,0.000621549250000532,"0.033,0.008","0.042,0.064",-0.033]
[2154,"ENSG00000103197.17","TSC2","chr16","+",2055401,2055519,2055418,2055519,2053341,2054440,2154,153130,"0,1","109,81","0,2",166,149,1,1,"1.0,0.992","1.0,0.973",0.01]
[2197,"ENSG00000162004.16","CCDC78","chr16","-",724321,724806,724321,724509,724910,724989,2197,"34,37","2,0","50,37","0,0",298,149,0.582786653434,0.973483481170866,"0.895,1.0","1.0,1.0",-0.052]
[2201,"ENSG00000140983.13","RHOT2","chr16","+",668487,668699,668655,668699,668352,668411,2201,709829,"4,11",285331,"7,2",298,149,0.515968898321,0.902347126481664,"0.989,0.974","0.953,0.988",0.011]
[2238,"ENSG00000104774.12","MAN2B1","chr19","-",12658427,12658510,12658427,12658507,12661259,12661376,2238,626771,"2,2",486454,"0,0",152,149,1,1,"0.997,0.997","1.0,1.0",-0.003]
[2256,"ENSG00000196547.14","MAN2A2","chr15","+",90911366,90911550,90911384,90911550,90911170,90911238,2256,"15,16",567655,"44,56",476504,167,149,{"v":1.30517152641E-10,"d":"1.31E-10"},{"v":1.74859248279775E-9,"d":"1.75E-09"},"0.023,0.021","0.076,0.09",-0.061]
[2263,"ENSG00000140854.12","KATNB1","chr16","+",57755789,57755917,57755840,57755917,57755344,57755494,2263,135185,275253,"57,31",107124,200,149,0.0295103964853,0.0912829981546411,"0.268,0.353","0.284,0.157",0.09]
[2278,"ENSG00000181991.15","MRPS11","chr15","+",88475109,88475239,88475171,88475239,88467907,88468024,2278,286304,"0,0",165188,"0,4",211,149,0.618659047881,1,"1.0,1.0","1.0,0.971",0.014]
[2294,"ENSG00000171045.14","TSNARE1","chr8","-",142315002,142315092,142315002,142315089,142318543,142318634,2294,"45,51","9,2","30,30","5,0",152,149,0.38312996699,0.729072238698501,"0.831,0.962","0.855,1.0",-0.031]
[2321,"ENSG00000144199.11","FAHD2B","chr2","-",97085698,97086198,97085698,97085861,97090108,97090325,2321,172174,"1,2","58,36","0,0",298,149,0.613416128458,1,"0.989,0.978","1.0,1.0",-0.016]
[2334,"ENSG00000134184.12","GSTM1","chr1","+",109688116,109688245,109688169,109688245,109687844,109687909,2334,"0,1",201243,"6,1",166142,202,149,0.850852402331,1,"0.0,0.003","0.026,0.005",-0.014]
[2353,"ENSG00000066651.19","TRMT11","chr6","+",126012969,126013101,126012974,126013101,126012770,126012852,2353,210123,"2,0",103142,"1,0",154,149,1,1,"0.99,1.0","0.99,1.0",0]
[2385,"ENSG00000008952.16","SEC62","chr3","+",169982636,169982911,169982659,169982911,169976945,169977051,2385,"0,0","1,0","3,1","2,0",172,149,1,1,"0.0,NA","0.565,1.0",-0.782]
[2392,"ENSG00000135297.15","MTO1","chr6","+",73482028,73482244,73482039,73482244,73480674,73480805,2392,"23,26",276218,"61,93",168121,160,149,{"v":1.07056585819e-10,"d":"1.07E-10"},{"v":1.46263635287803e-09,"d":"1.46E-09"},"0.072,0.1","0.253,0.417",-0.249]
[2413,"ENSG00000225138.7","SLC9A3-AS1","chr5","+",479781,480216,479865,480216,477805,477849,2413,126113,"23,14",117155,"7,9",233,149,0.00157525521423,0.00708437716464717,"0.778,0.838","0.914,0.917",-0.107]
[2442,"ENSG00000137575.11","SDCBP","chr8","+",58578032,58578208,58578047,58578208,58572204,58572314,2442,"119,80","0,1","98,94","1,3",164,149,0.556399049433,0.94687626582308,"1.0,0.986","0.989,0.966",0.015]
[2447,"ENSG00000137166.14","FOXP4","chr6","+",41585430,41585517,41585436,41585517,41584768,41584891,2447,152187,"10,7",145116,"3,6",155,149,0.289264951654,0.591876201348784,"0.936,0.963","0.979,0.949",-0.014]
[2473,"ENSG00000221988.12","PPT2","chr6","+",32155687,32155783,32155767,32155783,32155029,32155183,2473,901770,"11,17",599729,"10,18",229,149,0.456584771248,0.829635737940329,"0.982,0.967","0.975,0.963",0.005]
[2489,"ENSG00000115459.17","ELMOD3","chr2","+",85371085,85371562,85371439,85371562,85369738,85369830,2489,"86,64","0,0","36,29","0,2",298,149,0.680578565618,1,"1.0,1.0","1.0,0.879",0.06]
[2508,"ENSG00000198563.13","DDX39B","chr6","-",31540321,31540664,31540321,31540534,31541152,31541327,2508,509510,"2,0",802805,"0,0",279,149,1,1,"0.993,1.0","1.0,1.0",-0.004]
[2536,"ENSG00000239665.8","AL157392.3","chr10","+",13654183,13654427,13654352,13654427,13652845,13652882,2536,"8,4","0,1","13,13","0,0",298,149,1,1,"1.0,0.667","1.0,1.0",-0.166]
[2558,"ENSG00000112242.14","E2F3","chr6","+",20481205,20481425,20481223,20481425,20479845,20479957,2558,490459,"34,43",605747,"7,5",167,149,{"v":4.4408920985E-16,"d":"4.44E-16"},{"v":1.01455421963803E-14,"d":"1.01E-14"},"0.928,0.905","0.987,0.993",-0.073]
[2578,"ENSG00000108433.16","GOSR2","chr17","+",46931098,46931207,46931101,46931207,46929519,46929584,2578,470498,"25,29",608654,"28,25",152,149,0.210215503842,0.462418348371805,"0.949,0.944","0.955,0.962",-0.012]
[2599,"ENSG00000187688.14","TRPV2","chr17","+",16434858,16434969,16434889,16434969,16433573,16433698,2599,"0,2",180231,"0,7","10,15",180,149,2.14043049905E-4,1.16016928945239E-3,"0.0,0.007","0.0,0.279",-0.136]
[2620,"ENSG00000215041.9","NEURL4","chr17","-",7326710,7327009,7326710,7326910,7327164,7327230,2620,175260,"3,0",93131,"0,2",248,149,1,1,"0.972,1.0","1.0,0.975",-2E-3]
[2641,"ENSG00000258479.5","LINC00640","chr14","+",51350194,51350372,51350292,51350372,51349668,51349743,2641,"9,0","0,2","0,0","0,2",247,149,1,1,"1.0,0.0","NA,0.0",0.5]
[2659,"ENSG00000183258.11","DDX41","chr5","-",177515185,177515339,177515185,177515258,177515684,177515821,2659,"61,37",591630,"67,48",476432,230,149,0.00965676003221,0.0349252119263486,"0.063,0.037","0.084,0.067",-0.026]
[2681,"ENSG00000111653.19","ING4","chr12","-",6652661,6653050,6652661,6652767,6656726,6656798,2681,"48,41","0,0",158188,"0,2",298,149,1,1,"1.0,1.0","1.0,0.979",0.01]
[2703,"ENSG00000196696.12","PDXDC2P-NPIPB14P","chr16","-",70038904,70039100,70038904,70038985,70042350,70042416,2703,"51,43","32,24","39,19","9,14",264,149,0.376930000109,0.719420135996303,"0.474,0.503","0.71,0.434",-0.083]
[2721,"ENSG00000128059.8","PPAT","chr4","-",56406494,56406701,56406494,56406618,56407649,56407716,2721,630508,"24,31",392384,"37,50",232,149,{"v":3.19184140768e-05,"d":"3.19E-05"},2.05991757150896E-4,"0.944,0.913","0.872,0.831",0.077]
[2750,"ENSG00000163507.13","CIP2A","chr3","-",108566496,108566639,108566496,108566638,108568154,108568314,2750,"1,2","117,95","2,3","61,75",150,149,0.217590151443,0.475612842887928,"0.008,0.02","0.032,0.038",-0.021]
[2774,"ENSG00000117523.16","PRRC2C","chr1","+",171512994,171513172,171513000,171513172,171512031,171512200,2774,545487,220210,465420,175173,155,149,0.658314055451,1,"0.704,0.69","0.719,0.7",-0.013]
[2801,"ENSG00000142330.19","CAPN10","chr2","+",240596680,240596942,240596849,240596942,240596318,240596521,2801,221295,"2,12",375383,"2,9",298,149,0.139643053623,0.333653322344796,"0.982,0.925","0.989,0.955",-0.018]
[2809,"ENSG00000135365.15","PHF21A","chr11","-",45969814,45969904,45969814,45969901,45971115,45971367,2809,84101,"9,16","72,73","10,4",152,149,0.29735425248,0.605737856992542,"0.901,0.861","0.876,0.947",-0.03]
[2849,"ENSG00000167770.11","OTUB1","chr11","+",63997049,63997244,63997070,63997244,63996856,63996941,2849,12411184,"0,2",932943,"0,0",170,149,1,1,"1.0,0.998","1.0,1.0",-1E-3]
[2870,"ENSG00000185513.16","L3MBTL1","chr20","+",43536081,43536294,43536096,43536294,43535836,43535936,2870,"0,0","28,32","0,2","22,29",164,149,0.33369090431,0.659908572714744,"0.0,0.0","0.0,0.059",-0.029]
[2880,"ENSG00000119599.16","DCAF4","chr14","+",72954160,72954262,72954163,72954262,72951797,72951877,2880,"12,12","21,12","18,10","7,12",152,149,0.16470617759,0.380687940566853,"0.359,0.495","0.716,0.45",-0.156]
[2914,"ENSG00000134057.14","CCNB1","chr5","+",69177238,69177349,69177290,69177349,69174876,69175113,2914,321271,"0,0",240347,"2,2",201,149,1,1,"1.0,1.0","0.989,0.992",0.01]
[2935,"ENSG00000135426.15","TESPA1","chr12","-",54973476,54973535,54973476,54973519,54974399,54974607,2935,"0,5",796833,"12,15",696721,165,149,0.0590153537001,0.164790966773014,"0.0,0.005","0.015,0.018",-0.014]
[2948,"ENSG00000137070.17","IL11RA","chr9","+",34660803,34660936,34660853,34660936,34660503,34660600,2948,"5,4","5,18","12,15","1,7",199,149,0.000836142291312,0.00401978436049299,"0.428,0.143","0.9,0.616",-0.473]
[2979,"ENSG00000151651.15","ADAM8","chr10","-",133273253,133273443,133273253,133273430,133273761,133273838,2979,"8,12","1,2","32,22","0,0",162,149,0.0523805725723,0.149275631732674,"0.88,0.847","1.0,1.0",-0.137]
[3004,"ENSG00000120533.12","ENY2","chr8","+",109340443,109340563,109340490,109340563,109339319,109339390,3004,"34,31",183153,"33,26",195149,196,149,0.579784947753,0.971148570332383,"0.124,0.133","0.114,0.117",0.013]
[3023,"ENSG00000124279.11","FASTKD3","chr5","-",7861582,7861773,7861582,7861652,7862822,7862997,3023,"114,80",246283,302275,"71,51",270,149,0,0,"0.204,0.135","0.701,0.748",-0.555]
[3044,"ENSG00000249915.7","PDCD6","chr5","+",304176,306754,306601,306754,272710,272772,3044,13411385,"0,0",649730,"0,1",298,149,1,1,"1.0,1.0","1.0,0.997",2E-3]
[3066,"ENSG00000168944.15","CEP120","chr5","-",123389923,123390365,123389923,123390140,123391109,123391337,3066,"8,2","92,75","4,3","66,77",298,149,0.667855944812,1,"0.042,0.013","0.029,0.019",0.003]
[3081,"ENSG00000213658.11","LAT","chr16","+",28986381,28986446,28986384,28986446,28986134,28986216,3081,22052304,618712,12311441,381428,152,149,0.804463101143,1,"0.778,0.76","0.76,0.767",0.005]
[3085,"ENSG00000141994.15","DUS3L","chr19","-",5786748,5787171,5786748,5786845,5787295,5787361,3085,663631,"0,2",548562,"0,2",298,149,1,1,"1.0,0.994","1.0,0.993",1E-3]
[3115,"ENSG00000198589.11","LRBA","chr4","-",150321190,150321383,150321190,150321368,150325808,150325898,3115,"34,36",228163,"48,39","17,20",164,149,0,0,"0.119,0.167","0.72,0.639",-0.536]
[3149,"ENSG00000004897.11","CDC27","chr17","-",47156912,47157124,47156912,47156983,47157229,47157384,3149,855869,"22,20",325347,"2,10",290,149,0.223967211177,0.48558433523944,"0.952,0.957","0.988,0.947",-0.013]
[3152,"ENSG00000137207.11","YIPF3","chr6","-",43513068,43513200,43513068,43513098,43513358,43513451,3152,10351089,"27,18",674664,"84,79",251,149,0,0,"0.958,0.973","0.826,0.833",0.136]
[3171,"ENSG00000164066.12","INTU","chr4","+",127685441,127687867,127687740,127687867,127684408,127684486,3171,"12,21","1,0","12,13","0,0",298,149,1,1,"0.857,1.0","1.0,1.0",-0.072]
[3188,"ENSG00000148019.13","CEP78","chr9","+",78254835,78254964,78254842,78254964,78253231,78253277,3188,165100,"0,0",184197,"8,4",156,149,0.0102013633013,0.0365600284605362,"1.0,1.0","0.956,0.979",0.032]
[3215,"ENSG00000145331.13","TRMT10A","chr4","-",99559153,99559361,99559153,99559350,99563367,99563668,3215,"2,2","0,3","6,6","0,0",160,149,0.049437709752,0.142060612256873,"1.0,0.383","1.0,1.0",-0.308]
[3242,"ENSG00000171316.11","CHD7","chr8","+",60862195,60862336,60862228,60862336,60860903,60861125,3242,248161,"3,7",201175,"0,1",182,149,0.0369740320481,0.1108908133121,"0.985,0.95","1.0,0.993",-0.029]
[3262,"ENSG00000118495.19","PLAGL1","chr6","-",143966157,143966285,143966157,143966212,143968906,143968978,3262,"56,71","12,15","52,32","4,7",222,149,0.187411646847,0.421879692535877,"0.758,0.761","0.897,0.754",-0.066]
[3285,"ENSG00000113240.12","CLK4","chr5","-",178619837,178620673,178619837,178619896,178623255,178623416,3285,"112,84","41,20","6,0","20,8",298,149,{"v":1.16720744181e-10,"d":"1.17E-10"},{"v":1.5868280844148e-09,"d":"1.59E-09"},"0.577,0.677","0.13,0.0",0.562]
[3305,"ENSG00000161013.16","MGAT4B","chr5","-",179801553,179801719,179801553,179801694,179801783,179801969,3305,"9,7",635637,"16,13",551607,174,149,0.0287362211451,0.0892448206418275,"0.012,0.009","0.024,0.018",-0.01]
[3327,"ENSG00000148444.15","COMMD3","chr10","+",22318271,22319018,22318958,22319018,22317883,22317995,3327,"96,58","4,0",224214,"0,0",298,149,0.243074126613,0.518603995884129,"0.923,1.0","1.0,1.0",-0.038]
[3344,"ENSG00000154144.12","TBRG1","chr11","+",124626812,124627050,124626903,124627050,124626472,124626609,3344,"100,82",226170,163279,"59,47",240,149,0,0,"0.216,0.23","0.632,0.787",-0.487]
[3367,"ENSG00000147454.13","SLC25A37","chr8","+",23568258,23568378,23568321,23568378,23566775,23566965,3367,424503,"6,18",519558,"1,3",212,149,{"v":9.70149577082e-05,"d":"9.70E-05"},0.000563801712876035,"0.98,0.952","0.997,0.992",-0.028]
[3399,"ENSG00000144868.13","TMEM108","chr3","+",133229265,133229351,133229269,133229351,133045901,133046020,3399,"7,1","5,2","8,18","3,9",153,149,0.333461370405,0.659683956290235,"0.577,0.327","0.722,0.661",-0.24]
[3413,"ENSG00000113593.11","PPWD1","chr5","+",65569631,65569732,65569636,65569732,65568917,65568994,3413,"15,21","0,0","35,20","1,2",154,149,0.450661926249,0.821573830376556,"1.0,1.0","0.971,0.906",0.061]
[3429,"ENSG00000122335.15","SERAC1","chr6","-",158150452,158150589,158150452,158150563,158155314,158155351,3429,"27,40","2,0","23,19","1,0",175,149,1,1,"0.92,1.0","0.951,1.0",-0.016]
[3459,"ENSG00000170919.15","TPT1-AS1","chr13","+",45344304,45344446,45344378,45344446,45341598,45341630,3459,"20,16","0,5","1,11","0,0",223,149,0.00417072792383,0.0167658006167339,"1.0,0.681","1.0,1.0",-0.159]
[3470,"ENSG00000151208.16","DLG5","chr10","-",77819320,77822101,77819320,77819465,77824383,77824476,3470,"83,91","0,0","78,55","1,2",298,149,0.491883362233,0.873675031698065,"1.0,1.0","0.975,0.932",0.046]
[3496,"ENSG00000095319.14","NUP188","chr9","+",128958009,128958054,128958013,128958054,128956951,128957032,3496,633518,"5,6",212260,"4,8",153,149,0.0517424066296,0.147761631604432,"0.992,0.988","0.981,0.969",0.015]
[3508,"ENSG00000103994.17","ZNF106","chr15","-",42439032,42439813,42439032,42439552,42442072,42442414,3508,222210,"70,54",332275,"21,21",298,149,{"v":2.40785169581e-12,"d":"2.41E-12"},{"v":3.94630713702615e-11,"d":"3.95E-11"},"0.613,0.66","0.888,0.868",-0.241]
[3538,"ENSG00000161204.11","ABCF3","chr3","+",184187663,184187983,184187860,184187983,184186795,184186875,3538,"17,17","0,5","58,81","3,4",298,149,0.439934156262,0.808772768317616,"1.0,0.63","0.906,0.91",-0.093]
[3553,"ENSG00000145191.13","EIF2B5","chr3","+",184143441,184144224,184144098,184144224,184143051,184143142,3553,993833,"5,0",398395,"28,45",298,149,0,0,"0.99,1.0","0.877,0.814",0.15]
[3564,"ENSG00000143498.17","TAF1A","chr1","-",222579758,222579872,222579758,222579825,222584127,222584297,3564,"53,86","1,2","43,60","2,10",196,149,1.75534506861E-3,0.00781378242296442,"0.976,0.97","0.942,0.82",0.092]
[3603,"ENSG00000114859.15","CLCN2","chr3","-",184354547,184354714,184354547,184354658,184354903,184354973,3603,"6,8","14,10","21,29","6,6",205,149,{"v":1.19883753906e-05,"d":"1.20E-05"},{"v":8.30573075306982e-05,"d":"8.31E-05"},"0.238,0.368","0.718,0.778",-0.445]
[3621,"ENSG00000164068.15","RNF123","chr3","+",49697044,49697222,49697142,49697222,49691424,49691509,3621,"2,7",184251,"15,6","63,83",247,149,{"v":1.53033382055e-06,"d":"1.53E-06"},{"v":1.22618921486194E-5,"d":"1.23E-05"},"0.007,0.017","0.126,0.042",-0.072]
[3641,"ENSG00000139546.10","TARBP2","chr12","+",53503712,53503808,53503729,53503808,53503026,53503212,3641,"37,43","3,2","71,68","19,21",166,149,{"v":9.5644903631e-05,"d":"9.56E-05"},0.000556619779517111,"0.917,0.951","0.77,0.744",0.177]
[3663,"ENSG00000155324.9","GRAMD2B","chr5","+",126484398,126484524,126484401,126484524,126483462,126483574,3663,"0,5","40,31","4,2","36,37",152,149,0.71358602697,1,"0.0,0.137","0.098,0.05",-0.006]
[3682,"ENSG00000204599.14","TRIM39","chr6","+",30328888,30329041,30328908,30329041,30327651,30327696,3682,"32,24","21,13","17,27","4,4",169,149,2.2807658086E-3,0.00987696650168135,"0.573,0.619","0.789,0.856",-0.227]
[3703,"ENSG00000174564.12","IL20RB","chr3","+",136980330,136980592,136980465,136980592,136969244,136969378,3703,"7,0","0,1","0,1","0,0",284,149,1,1,"1.0,0.0","NA,1.0",-0.5]
[3723,"ENSG00000105948.13","TTC26","chr7","+",139146983,139147290,139147144,139147290,139142255,139142305,3723,"0,2","34,33","5,2","26,23",298,149,0.0159526032569,0.0540862382704299,"0.0,0.029","0.088,0.042",-0.051]
[3745,"ENSG00000169714.16","CNBP","chr3","-",129171445,129171538,129171445,129171508,129171654,129171771,3745,35453395,"16,17",35173403,"2,0",179,149,1,1,"0.995,0.994","0.999,1.0",-0.005]
[3763,"ENSG00000138035.14","PNPT1","chr2","-",55643318,55643425,55643318,55643412,55644636,55644720,3763,12051050,"5,1",711742,"0,2",162,149,1,1,"0.996,0.999","1.0,0.997",-1E-3]
[3789,"ENSG00000175455.14","CCDC14","chr3","-",123913724,123915718,123913724,123915132,123933672,123933755,3789,867835,"0,0",351392,"1,0",298,149,1,1,"1.0,1.0","0.994,1.0",0.003]
[3820,"ENSG00000113163.16","COL4A3BP","chr5","-",75385901,75386057,75385901,75386034,75389591,75389687,3820,"1,0","93,96","4,2",151115,172,149,0.89450511801,1,"0.009,0.0","0.022,0.015",-0.014]
[3840,"ENSG00000135926.14","TMBIM1","chr2","-",218277934,218278165,218277934,218277974,218278514,218278565,3840,"19,19",17941585,90121,32032953,298,149,{"v":3.79047535127e-05,"d":"3.79E-05"},0.000240140657662964,"0.005,0.006","0.014,0.02",-0.012]
[3865,"ENSG00000198919.12","DZIP3","chr3","+",108647942,108648962,108648917,108648962,108644163,108644781,3865,"18,25","0,0","12,23","0,4",298,149,0.0171095419035,0.0573615745254141,"1.0,1.0","1.0,0.742",0.129]
[3868,"ENSG00000170776.21","AKAP13","chr15","+",85710578,85710645,85710581,85710645,85708018,85708086,3868,334354,"19,16",396383,"28,40",152,149,0.0171016722322,0.0573615745254141,"0.945,0.956","0.933,0.904",0.032]
[3909,"ENSG00000197111.15","PCBP2","chr12","+",53459799,53461143,53461014,53461143,53459271,53459403,3909,228257,49384201,"31,14",49864987,298,149,0,0,"0.023,0.03","0.003,0.001",0.025]
[3910,"ENSG00000197111.15","PCBP2","chr12","+",53462480,53462567,53462492,53462567,53461014,53461143,3910,33682933,40203820,28673198,36603861,161,149,0.970282542326,1,"0.437,0.415","0.42,0.434",-1E-3]
[3932,"ENSG00000149823.8","VPS51","chr11","+",65107186,65107727,65107580,65107727,65096997,65097127,3932,"31,18",773845,"10,20",547573,298,149,0.590776999906,0.981866624640134,"0.02,0.011","0.009,0.017",2E-3]
[3944,"ENSG00000100949.14","RABGGTA","chr14","-",24271112,24271248,24271112,24271169,24271486,24271549,3944,"8,8","51,31","28,19","24,18",228,149,{"v":1.76429028831e-07,"d":"1.76E-07"},{"v":1.63760198655326e-06,"d":"1.64E-06"},"0.093,0.144","0.433,0.408",-0.302]
[3964,"ENSG00000151276.23","MAGI1","chr3","-",65470282,65470487,65470282,65470484,65478591,65478798,3964,"32,26",149176,"26,10",135104,152,149,0.438408305467,0.807148962069427,"0.174,0.126","0.159,0.086",0.027]
[3993,"ENSG00000166822.12","TMEM170A","chr16","-",75451668,75451839,75451668,75451837,75464467,75464698,3993,"88,87","0,1",127149,"1,0",151,149,1,1,"1.0,0.988","0.992,1.0",-2E-3]
[4009,"ENSG00000101197.12","BIRC7","chr20","+",63239357,63239610,63239411,63239610,63239161,63239233,4009,"2,0","0,0","3,0","1,0",203,149,1,1,"1.0,NA","0.688,NA",0.312]
[4025,"ENSG00000104763.18","ASAH1","chr8","-",18064456,18064531,18064456,18064471,18067219,18067298,4025,25752178,"8,18",165137,"0,1",209,149,1,1,"0.996,0.989","1.0,0.99",-0.003]
[4054,"ENSG00000111325.16","OGFOD2","chr12","+",122976583,122976767,122976653,122976767,122976252,122976401,4054,"19,62","21,32","84,69","6,4",219,149,{"v":6.63345600671e-10,"d":"6.63E-10"},{"v":8.23521716521647E-9,"d":"8.24E-09"},"0.381,0.569","0.905,0.921",-0.438]
[4064,"ENSG00000134644.15","PUM1","chr1","-",30980061,30980178,30980061,30980166,30981311,30981405,4064,"23,27",179200,"56,95",197177,161,149,{"v":1.52318607061E-6,"d":"1.52E-06"},{"v":1.22282498388855E-5,"d":"1.22E-05"},"0.106,0.111","0.208,0.332",-0.162]
[4087,"ENSG00000177311.11","ZBTB38","chr3","+",141438242,141438365,141438267,141438365,141403926,141404031,4087,"0,4","3,4","12,0","0,0",174,149,1,1,"0.0,0.461","1.0,NA",-0.769]
[4123,"ENSG00000134759.13","ELP2","chr18","+",36167100,36167222,36167152,36167222,36164474,36164667,4123,461475,"18,12",125144,"12,8",201,149,0.0154676790344,0.0526358072352397,"0.95,0.967","0.885,0.93",0.051]
[4131,"ENSG00000116786.12","PLEKHM2","chr1","+",15731888,15732048,15731949,15732048,15731191,15731257,4131,516621,"21,21",735704,"18,17",210,149,0.0978733884138,0.250668316897975,"0.946,0.955","0.967,0.967",-0.017]
[4151,"ENSG00000228288.6","PCAT6","chr1","+",202811574,202811913,202811688,202811913,202810961,202811370,4151,"0,2","1,2","0,4","0,0",263,149,1,1,"0.0,0.362","NA,1.0",-0.819]
[4176,"ENSG00000116750.13","UCHL5","chr1","-",193022925,193023039,193022925,193023036,193023843,193023946,4176,979896,14371252,622577,677658,152,149,0.0246205838224,0.0782893027757527,"0.4,0.412","0.474,0.462",-0.062]
[4198,"ENSG00000137941.16","TTLL7","chr1","-",83906328,83906523,83906328,83906463,83907455,83907661,4198,"3,6","9,6","0,0","26,13",209,149,{"v":2.71416097819E-6,"d":"2.71E-06"},{"v":2.08219583645972e-05,"d":"2.08E-05"},"0.192,0.416","0.0,0.0",0.304]
[4223,"ENSG00000172765.17","TMCC1","chr3","-",129827802,129828508,129827802,129828077,129832773,129832826,4223,"66,53","6,2","72,64","2,8",298,149,0.908042170259,1,"0.846,0.93","0.947,0.8",0.015]
[4240,"ENSG00000115204.14","MPV17","chr2","-",27312213,27312589,27312213,27312246,27312679,27312772,4240,936851,"5,3",495483,"3,6",298,149,0.449232276311,0.819327747404249,"0.989,0.993","0.988,0.976",0.009]
[4259,"ENSG00000234741.7","GAS5","chr1","-",173864256,173865282,173864256,173864704,173865470,173865547,4259,56595028,"7,13",75458244,170223,298,149,0,0,"0.998,0.995","0.957,0.949",0.043]
[4275,"ENSG00000234741.7","GAS5","chr1","-",173865856,173866206,173865856,173865894,173866760,173866796,4275,556493,"0,3",398475,"0,9",298,149,0.304290492573,0.616084241920871,"1.0,0.988","1.0,0.963",0.012]
[4307,"ENSG00000211456.10","SACM1L","chr3","+",45735234,45735373,45735245,45735373,45723474,45723543,4307,"11,12","0,0","23,22","3,2",160,149,0.0096926134167,0.0350243324900623,"1.0,1.0","0.877,0.911",0.106]
[4324,"ENSG00000115355.16","CCDC88A","chr2","-",55296257,55296523,55296257,55296520,55301205,55301277,4324,"16,29","2,0","24,34","0,0",152,149,0.962030033177,1,"0.887,1.0","1.0,1.0",-0.056]
[4342,"ENSG00000172954.13","LCLAT1","chr2","+",30476401,30476635,30476576,30476635,30459551,30459722,4342,"0,2","1,0","1,1","0,0",298,149,0.101346779278,0.257891635640519,"0.0,1.0","1.0,1.0",-0.5]
[4370,"ENSG00000140264.19","SERF2","chr15","+",43793686,43794046,43793709,43794046,43792974,43793083,4370,186152,1204511206,695692,875710213,172,149,0,0,"0.013,0.012","0.064,0.055",-0.047]
[4392,"ENSG00000168067.11","MAP4K2","chr11","-",64800763,64800826,64800763,64800799,64800899,64801031,4392,301287,"2,1","108,94","5,0",176,149,0.460347037022,0.83373181437507,"0.992,0.996","0.948,1.0",0.02]
[4413,"ENSG00000114021.11","NIT2","chr3","+",100345584,100346255,100346180,100346255,100341072,100341161,4413,650608,"4,5","86,73","52,50",298,149,0,0,"0.988,0.984","0.453,0.422",0.548]
[4456,"ENSG00000147789.15","ZNF7","chr8","+",144829426,144829604,144829444,144829604,144829042,144829090,4456,"7,1","2,5","4,3","2,6",167,149,0.980716683422,1,"0.757,0.151","0.641,0.308",-0.021]
[4471,"ENSG00000132471.11","WBP2","chr17","-",75847486,75847609,75847486,75847597,75847795,75847930,4471,599560,"3,2",764953,"3,1",161,149,1,1,"0.995,0.996","0.996,0.999",-2E-3]
[4487,"ENSG00000146918.19","NCAPG2","chr7","-",158675476,158675656,158675476,158675616,158679959,158680085,4487,585462,"11,11",231226,"29,18",189,149,{"v":4.80178752316e-09,"d":"4.80E-09"},{"v":5.35231504429648e-08,"d":"5.35E-08"},"0.977,0.971","0.863,0.908",0.089]
[4493,"ENSG00000205336.11","ADGRG1","chr16","+",57651184,57651622,57651481,57651622,57650252,57650351,4493,"43,51","0,1","25,10","0,0",298,149,1,1,"1.0,0.962","1.0,1.0",-0.019]
[4526,"ENSG00000173559.12","NABP1","chr2","+",191683289,191683804,191683728,191683804,191682491,191682595,4526,"46,36","10,7","2,4","0,0",298,149,1.67714202198E-4,0.000930337042694323,"0.697,0.72","1.0,1.0",-0.292]
[4544,"ENSG00000239779.6","WBP1","chr2","+",74459437,74459745,74459642,74459745,74458996,74459098,4544,"31,41","6,4","50,29","7,4",298,149,0.90861559791,1,"0.721,0.837","0.781,0.784",-0.004]
[4551,"ENSG00000203875.11","SNHG5","chr6","-",85660949,85661355,85660949,85661134,85663673,85663726,4551,"0,0","1,0","45,48","3,3",298,149,1,1,"0.0,NA","0.882,0.889",-0.885]
[4582,"ENSG00000213930.11","GALT","chr9","+",34648047,34648171,34648114,34648171,34647656,34647961,4582,"13,12",120118,"14,11","9,13",216,149,{"v":3.84867726577e-09,"d":"3.85E-09"},{"v":4.37220281712748e-08,"d":"4.37E-08"},"0.07,0.066","0.518,0.369",-0.376]
[4605,"ENSG00000112303.13","VNN2","chr6","-",132757670,132757902,132757670,132757759,132760631,132760803,4605,"0,0","2,0","2,2","0,0",292,149,1,1,"0.0,NA","1.0,1.0",-1]
[4622,"ENSG00000169554.19","ZEB2","chr2","-",144398300,144400345,144398300,144400270,144401198,144401307,4622,"18,17",532404,"51,56",562477,224,149,{"v":1.41147219657e-06,"d":"1.41E-06"},{"v":1.13754508514625e-05,"d":"1.14E-05"},"0.022,0.027","0.057,0.072",-0.04]
[4648,"ENSG00000067829.18","IDH3G","chrX","-",153785765,153786272,153785765,153785973,153786354,153786449,4648,550805,"1,0",506542,"44,53",298,149,0,0,"0.996,1.0","0.852,0.836",0.154]
[4668,"ENSG00000162613.16","FUBP1","chr1","-",77967048,77967101,77967048,77967098,77967626,77967666,4668,603577,12031175,711663,12231203,152,149,0.237188921752,0.508734861524609,"0.329,0.325","0.363,0.351",-0.03]
[4684,"ENSG00000067369.13","TP53BP1","chr15","-",43413118,43413334,43413118,43413328,43415593,43415809,4684,177159,"0,1",166205,"1,1",155,149,1,1,"1.0,0.993","0.994,0.995",2E-3]
[4711,"ENSG00000143621.16","ILF2","chr1","-",153663018,153663276,153663018,153663133,153664042,153664130,4711,49234428,"1,0",32753208,"2,2",292,149,1,1,"1.0,1.0","0.999,0.999",1E-3]
[4712,"ENSG00000143621.16","ILF2","chr1","-",153668452,153668576,153668452,153668557,153669835,153669878,4712,"8,4",34863059,"20,18",24762606,168,149,1,1,"0.002,0.001","0.007,0.006",-0.005]
[4741,"ENSG00000188529.14","SRSF10","chr1","-",23974973,23975080,23974973,23975077,23977910,23978273,4741,119116,"0,0",147161,"2,0",152,149,1,1,"1.0,1.0","0.986,1.0",0.007]
[4747,"ENSG00000135632.11","SMYD5","chr2","+",73219951,73220190,73220050,73220190,73218860,73218969,4747,"31,64",371422,137137,348360,248,149,{"v":1.10689235555E-13,"d":"1.11E-13"},{"v":2.09099278008568e-12,"d":"2.09E-12"},"0.048,0.084","0.191,0.186",-0.122]
[4767,"ENSG00000132716.18","DCAF8","chr1","-",160261284,160261350,160261284,160261325,160262116,160262451,4767,"43,33","0,1","28,22","0,0",174,149,1,1,"1.0,0.966","1.0,1.0",-0.017]
[4817,"ENSG00000168679.17","SLC16A4","chr1","-",110362850,110363913,110362850,110363893,110375457,110375551,4817,"0,1","0,6","1,2","11,8",169,149,1,1,"NA,0.128","0.074,0.181",1E-3]
[4820,"ENSG00000105048.16","TNNT1","chr19","-",55134065,55134204,55134065,55134156,55137102,55137212,4820,"5,9",298299,"37,33",161226,197,149,{"v":5.19584375525E-14,"d":"5.20E-14"},{"v":1.00207284330902e-12,"d":"1.00E-12"},"0.013,0.022","0.148,0.099",-0.106]
[4837,"ENSG00000115271.10","GCA","chr2","+",162359043,162359552,162359493,162359552,162356757,162356905,4837,313267,"0,0",240283,"1,2",298,149,1,1,"1.0,1.0","0.992,0.986",0.011]
[4857,"ENSG00000119820.10","YIPF4","chr2","+",32301381,32301495,32301442,32301495,32290482,32290636,4857,171155,"0,0",149209,"2,8",210,149,0.00826434250547,0.0304548626595688,"1.0,1.0","0.981,0.949",0.035]
[4885,"ENSG00000005448.16","WDR54","chr2","+",74425074,74425237,74425096,74425237,74423854,74423982,4885,"12,16","3,4","16,11","8,5",171,149,0.192783711259,0.431163785725697,"0.777,0.777","0.635,0.657",0.131]
[4902,"ENSG00000113407.13","TARS","chr5","+",33453288,33453412,33453293,33453412,33445323,33445404,4902,"43,37","1,0","48,47","0,0",154,149,1,1,"0.977,1.0","1.0,1.0",-0.012]
[4926,"ENSG00000051523.10","CYBA","chr16","-",88646115,88646838,88646115,88646197,88647100,88647175,4926,49254761,"2,0",53816678,"16,10",298,149,1,1,"0.999,1.0","0.994,0.997",0.004]
[4946,"ENSG00000131051.22","RBM39","chr20","-",35709223,35709274,35709223,35709256,35713018,35713096,4946,13091259,879912,15861598,11111094,167,149,0.9509077042,1,"0.571,0.552","0.56,0.566",-1E-3]
[4971,"ENSG00000137804.12","NUSAP1","chr15","+",41350987,41351129,41351032,41351129,41349097,41349241,4971,9971123,422320,14671430,"42,31",194,149,0,0,"0.645,0.729","0.964,0.973",-0.281]
[4995,"ENSG00000169189.16","NSMCE1","chr16","-",27241352,27241889,27241352,27241484,27257434,27257581,4995,"13,12","0,1","7,7","0,0",298,149,1,1,"1.0,0.857","1.0,1.0",-0.072]
[5015,"ENSG00000085276.17","MECOM","chr3","-",169115382,169116739,169115382,169115767,169121055,169121209,5015,153158,"30,24",185192,104103,298,149,{"v":1.20434329176E-9,"d":"1.20E-09"},{"v":1.46017820446866E-8,"d":"1.46E-08"},"0.718,0.767","0.471,0.482",0.266]
[5035,"ENSG00000150637.8","CD226","chr18","-",69947360,69947532,69947360,69947433,69961591,69961803,5035,"6,12","2,5","5,4","0,0",248,149,{"v":1.80298952263e-05,"d":"1.80E-05"},1.20972428083904E-4,"0.643,0.59","1.0,1.0",-0.383]
[5064,"ENSG00000180376.16","CCDC66","chr3","+",56563651,56564125,56563683,56564125,56559568,56559594,5064,"8,3",90118,"26,9","30,29",181,149,{"v":2.27020851007e-08,"d":"2.27E-08"},{"v":2.37113843501391e-07,"d":"2.37E-07"},"0.068,0.02","0.416,0.203",-0.266]
[5081,"ENSG00000120948.17","TARDBP","chr1","+",11023160,11023329,11023192,11023329,11022123,11022250,5081,624586,"28,34",444479,"16,11",181,149,0.0184076090239,0.0612577454394874,"0.948,0.934","0.958,0.973",-0.024]
[5111,"ENSG00000013573.16","DDX11","chr12","+",31089402,31090094,31089890,31090094,31089043,31089151,5111,819765,"0,0",267262,"0,1",298,149,1,1,"1.0,1.0","1.0,0.992",0.004]
[5143,"ENSG00000187531.13","SIRT7","chr17","-",81914293,81915512,81914293,81914530,81915610,81915681,5143,190215,"0,0",227214,"4,0",298,149,0.556502462272,0.94687626582308,"1.0,1.0","0.966,1.0",0.017]
[5158,"ENSG00000162302.12","RPS6KA4","chr11","+",64368467,64368601,64368488,64368601,64368131,64368260,5158,135178,"12,31","33,31","8,11",170,149,0.032709280619,0.0999108891982935,"0.908,0.834","0.783,0.712",0.123]
[5169,"ENSG00000058600.15","POLR3E","chr16","+",22313619,22313727,22313657,22313727,22309427,22309510,5169,743889,"4,2",791708,"14,5",187,149,0.227564873804,0.491585178029844,"0.993,0.997","0.978,0.991",0.011]
[5194,"ENSG00000025708.13","TYMP","chr22","-",50526000,50526156,50526000,50526141,50526245,50526476,5194,"3,3","59,73","3,3","38,59",164,149,0.676558104791,1,"0.044,0.036","0.067,0.044",-0.016]
[5222,"ENSG00000196204.11","RNF216P1","chr7","+",4984909,4985075,4984961,4985075,4983670,4983773,5222,178173,171152,"16,18",161144,201,149,0,0,"0.436,0.458","0.069,0.085",0.37]
[5238,"ENSG00000138674.16","SEC31A","chr4","-",82881857,82881940,82881857,82881937,82890750,82891095,5238,"18,16","0,2","33,28","0,1",152,149,0.62836239097,1,"1.0,0.887","1.0,0.965",-0.039]
[5270,"ENSG00000134744.13","TUT4","chr1","-",52436754,52436978,52436754,52436963,52438219,52438335,5270,168147,288286,102130,"85,66",164,149,{"v":1.44773168675E-7,"d":"1.45E-07"},{"v":1.36122889775711e-06,"d":"1.36E-06"},"0.346,0.318","0.522,0.642",-0.25]
[5298,"ENSG00000061938.17","TNK2","chr3","-",195870113,195870378,195870113,195870205,195872275,195872470,5298,"12,8",197150,"22,25",167164,298,149,0.0011077101761,0.00519877786666514,"0.03,0.026","0.062,0.071",-0.039]
[5312,"ENSG00000144306.14","SCRN3","chr2","+",174398274,174398442,174398365,174398442,174395744,174395817,5312,153164,"1,6",121170,"0,0",240,149,0.0702764479967,0.191208196599945,"0.99,0.944","1.0,1.0",-0.033]
[5338,"ENSG00000000460.16","C1orf112","chr1","+",169804074,169804240,169804111,169804240,169803168,169803309,5338,314283,"37,45",209280,"8,12",186,149,{"v":1.04378403087E-6,"d":"1.04E-06"},{"v":8.5534594545503e-06,"d":"8.55E-06"},"0.872,0.834","0.954,0.949",-0.099]
[5372,"ENSG00000173209.23","AHSA2P","chr2","+",61178980,61179171,61178985,61179171,61177417,61178384,5372,"14,33","4,0","18,8","0,0",154,149,0.08211305735,0.217074779918249,"0.772,1.0","1.0,1.0",-0.114]
[5392,"ENSG00000149269.9","PAK1","chr11","-",77392330,77392541,77392330,77392538,77473551,77474062,5392,"7,14","1,0","10,13","4,4",152,149,0.000664314583569,3.27716038054137E-3,"0.873,1.0","0.71,0.761",0.201]
[5413,"ENSG00000203705.10","TATDN3","chr1","+",212812226,212812328,212812247,212812328,212796516,212796590,5413,"11,10","0,0","26,34","0,1",170,149,1,1,"1.0,1.0","1.0,0.968",0.016]
[5434,"ENSG00000182264.8","IZUMO1","chr19","-",48741788,48741972,48741788,48741942,48742208,48742309,5434,"1,4","0,0","0,3","0,1",179,149,1,1,"1.0,1.0","NA,0.714",0.286]
[5457,"ENSG00000154222.14","CC2D1B","chr1","-",52359704,52359883,52359704,52359836,52360073,52360233,5457,126209,"2,7",223207,"6,6",196,149,0.826652677574,1,"0.98,0.958","0.966,0.963",0.005]
[5485,"ENSG00000163902.11","RPN1","chr3","-",128644534,128644650,128644534,128644646,128644918,128644983,5485,"2,7","3,1","0,0","4,0",153,149,1,1,"0.394,0.872","0.0,NA",0.633]
[5501,"ENSG00000173715.16","C11orf80","chr11","+",66838366,66838445,66838369,66838445,66828265,66828364,5501,"36,26","30,35","6,16","4,3",152,149,0.018585000013,0.0617489603797311,"0.541,0.421","0.595,0.839",-0.236]
[5525,"ENSG00000128739.22","SNRPN","chr15","+",24974287,24974456,24974310,24974456,24967931,24968082,5525,"4,22",578478,"10,12",237237,172,149,0.0619528063963,0.17160141063611,"0.006,0.038","0.035,0.042",-0.017]
[5544,"ENSG00000132466.18","ANKRD17","chr4","-",73135116,73135265,73135116,73135262,73141740,73141843,5544,328310,"48,49",151145,"33,27",152,149,0.183246099236,0.415094209495806,"0.87,0.861","0.818,0.84",0.036]
[5564,"ENSG00000127054.20","INTS11","chr1","-",1312592,1312949,1312592,1312700,1313034,1313124,5564,8991006,"1,0",621626,"0,0",298,149,1,1,"0.998,1.0","1.0,1.0",-1E-3]
[5567,"ENSG00000127054.20","INTS11","chr1","-",1312592,1313124,1312592,1312949,1313508,1313592,5567,12151472,"0,0",830719,"2,0",298,149,1,1,"1.0,1.0","0.995,1.0",2E-3]
[5587,"ENSG00000073331.17","ALPK1","chr4","+",112377677,112377898,112377729,112377898,112297342,112297469,5587,"8,5","1,0","25,39","0,0",201,149,1,1,"0.856,1.0","1.0,1.0",-0.072]
[5608,"ENSG00000078269.14","SYNJ2","chr6","+",158061991,158062164,158062054,158062164,158054966,158055028,5608,"22,15","0,0","9,11","1,0",212,149,1,1,"1.0,1.0","0.863,1.0",0.069]
[5631,"ENSG00000134453.15","RBM17","chr10","+",6106140,6106238,6106143,6106238,6104930,6105097,5631,814770,"4,1",641563,"5,2",152,149,1,1,"0.995,0.999","0.992,0.996",0.003]
[5650,"ENSG00000139370.11","SLC15A4","chr12","-",128809942,128810111,128809942,128810053,128814774,128815070,5650,"109,96","9,6",140177,"1,7",207,149,0.0138241245593,0.0478278952733729,"0.897,0.92","0.99,0.948",-0.06]
[5670,"ENSG00000160767.20","FAM189B","chr1","-",155251732,155251908,155251732,155251905,155253624,155253732,5670,"25,26",195152,"17,23",130181,152,149,0.561623688351,0.953242989663291,"0.112,0.144","0.114,0.111",0.015]
[5692,"ENSG00000164327.12","RICTOR","chr5","-",38945490,38945724,38945490,38945610,38947263,38947441,5692,113109,"0,1",262173,"4,0",263,149,0.612598369509,1,"1.0,0.984","0.974,1.0",0.005]
[5713,"ENSG00000077150.18","NFKB2","chr10","+",102402251,102402524,102402254,102402524,102402047,102402159,5713,"63,52","56,56","54,63","66,58",152,149,0.693130305751,1,"0.524,0.477","0.445,0.516",0.02]
[5738,"ENSG00000122390.18","NAA60","chr16","+",3484690,3485083,3484761,3485083,3482501,3482598,5738,178245,"7,11",251253,"2,0",220,149,{"v":3.47107170977e-05,"d":"3.47E-05"},0.000222721216310587,"0.945,0.938","0.988,1.0",-0.052]
[5768,"ENSG00000076864.19","RAP1GAP","chr1","-",21597960,21598064,21597960,21598040,21598399,21598502,5768,"4,6","2,0","8,2","0,0",173,149,0.582605940617,0.973483481170866,"0.633,1.0","1.0,1.0",-0.183]
[5778,"ENSG00000054523.17","KIF1B","chr1","+",10282321,10282533,10282399,10282533,10279096,10279138,5778,"5,0","1,0","9,9","0,0",227,149,1,1,"0.766,NA","1.0,1.0",-0.234]
[5813,"ENSG00000153234.13","NR4A2","chr2","-",156326149,156326328,156326149,156326207,156326717,156326920,5813,"10,13","2,1","41,41","1,4",270,149,0.795467237127,1,"0.734,0.878","0.958,0.85",-0.098]
[5843,"ENSG00000223960.6","AC009948.1","chr2","+",178430677,178430889,178430694,178430889,178426365,178426505,5843,"25,13","66,44","9,10","0,1",166,149,1,1,"0.254,0.21","1.0,0.9",-0.718]
[5851,"ENSG00000176715.16","ACSF3","chr16","+",89145213,89145401,89145266,89145401,89133135,89133262,5851,"4,0",161152,"7,4",125142,202,149,0.0391727062097,0.116687949927098,"0.018,0.0","0.04,0.02",-0.021]
[5887,"ENSG00000107938.17","EDRF1","chr10","+",125737917,125737989,125737922,125737989,125735643,125735904,5887,162214,"2,0",143101,"1,1",154,149,1,1,"0.987,1.0","0.993,0.99",2E-3]
[5901,"ENSG00000106348.17","IMPDH1","chr7","-",128409288,128409484,128409288,128409366,128409755,128409982,5901,"8,4","4,1","6,7","0,1",267,149,0.00197002661215,0.00864414322463489,"0.527,0.691","1.0,0.796",-0.289]
[5937,"ENSG00000241370.5","RPP21","chr6","+",30345466,30345573,30345490,30345573,30345297,30345398,5937,"27,18",481498,"17,37",376411,173,149,0.0874398055419,0.22810264465523,"0.046,0.03","0.037,0.072",-0.016]
[5989,"ENSG00000114861.20","FOXP1","chr3","-",71112535,71112637,71112535,71112628,71198201,71198392,5989,"35,22","0,0","39,24","0,1",158,149,1,1,"1.0,1.0","1.0,0.958",0.021]
[6019,"ENSG00000143801.16","PSEN2","chr1","+",226891742,226891844,226891745,226891844,226891277,226891361,6019,118107,"63,64","62,81","41,27",152,149,0.483213125171,0.863081293784859,"0.647,0.621","0.597,0.746",-0.037]
[6041,"ENSG00000162927.13","PUS10","chr2","-",60965057,60967613,60965057,60965103,60971522,60971557,6041,"47,32","0,0","8,11","11,7",298,149,{"v":2.16493489802e-13,"d":"2.16E-13"},{"v":3.98973446872885e-12,"d":"3.99E-12"},"1.0,1.0","0.267,0.44",0.646]
[6060,"ENSG00000105404.10","RABAC1","chr19","-",41956680,41956934,41956680,41956890,41958285,41958383,6060,"79,96","1,0",134158,"0,4",193,149,0.563782209308,0.954757170061516,"0.984,1.0","1.0,0.968",0.008]
[6079,"ENSG00000159214.12","CCDC24","chr1","+",43993886,43993964,43993889,43993964,43992522,43992639,6079,"7,0","10,11","0,2","4,1",152,149,0.375197906943,0.716939226331405,"0.407,0.0","0.0,0.662",-0.128]
[6099,"ENSG00000115758.12","ODC1","chr2","-",10444473,10444647,10444473,10444547,10444930,10445049,6099,67146295,"63,54",42794762,"5,3",249,149,0.00760990800409,0.0284402735817568,"0.985,0.986","0.998,0.999",-0.013]
[6115,"ENSG00000163482.11","STK36","chr2","+",218673624,218673765,218673664,218673765,218672740,218672913,6115,"29,36","5,0","16,18","1,0",189,149,0.0451010125088,0.131559161707871,"0.821,1.0","0.927,1.0",-0.053]
[6133,"ENSG00000132781.17","MUTYH","chr1","-",45333412,45333594,45333412,45333564,45334390,45334511,6133,"69,57","94,76","46,59","12,26",179,149,{"v":1.57324323791e-07,"d":"1.57E-07"},{"v":1.47090261239995E-6,"d":"1.47E-06"},"0.379,0.384","0.761,0.654",-0.326]
[6152,"ENSG00000102710.19","SUPT20H","chr13","-",37017244,37017364,37017244,37017328,37019341,37019397,6152,297262,"37,29",219258,"79,85",185,149,{"v":3.56205220875e-09,"d":"3.56E-09"},{"v":4.08576749200051e-08,"d":"4.09E-08"},"0.866,0.879","0.691,0.71",0.172]
[6170,"ENSG00000244026.6","FAM86DP","chr3","-",75426449,75426621,75426449,75426599,75429135,75429237,6170,"1,3","2,3","3,2","0,0",171,149,{"v":5.06655285648E-6,"d":"5.07E-06"},{"v":3.74148912188678E-5,"d":"3.74E-05"},"0.303,0.466","1.0,1.0",-0.615]
[6191,"ENSG00000143379.12","SETDB1","chr1","+",150962973,150963741,150963529,150963741,150962586,150962719,6191,310275,"2,8",229188,"6,4",298,149,0.526946445984,0.917482023209177,"0.987,0.945","0.95,0.959",0.012]
[6207,"ENSG00000006025.11","OSBPL7","chr17","-",47816106,47816482,47816106,47816202,47816562,47816695,6207,75100,"2,4","105,52","1,1",298,149,0.0711747812453,0.193019117353588,"0.949,0.926","0.981,0.963",-0.034]
[6226,"ENSG00000152990.13","ADGRA3","chr4","-",22413600,22413814,22413600,22413760,22420885,22421089,6226,"21,32","9,0","28,9","1,2",203,149,0.249173203313,0.528759819619935,"0.631,1.0","0.954,0.768",-0.045]
[6230,"ENSG00000160753.15","RUSC1","chr1","+",155325566,155325672,155325600,155325672,155325101,155325178,6230,"65,61","0,0","63,68","2,0",183,149,1,1,"1.0,1.0","0.962,1.0",0.019]
[6265,"ENSG00000184445.11","KNTC1","chr12","+",122613625,122613761,122613703,122613761,122613111,122613230,6265,780801,"22,9",341373,"47,21",227,149,{"v":1.66032632087E-10,"d":"1.66E-10"},{"v":2.19602650382374E-9,"d":"2.20E-09"},"0.959,0.983","0.826,0.921",0.098]
[6282,"ENSG00000078487.17","ZCWPW1","chr7","-",100415974,100416097,100415974,100416094,100416304,100416456,6282,"38,38","11,9","2,1","0,0",152,149,0.000438931139892,0.00225390460874573,"0.772,0.805","1.0,1.0",-0.212]
[6289,"ENSG00000114857.17","NKTR","chr3","+",42619663,42621516,42621428,42621516,42619019,42619127,6289,330335,"0,0",290277,"21,14",298,149,{"v":7.09821090794e-12,"d":"7.10E-12"},{"v":1.0941535884674E-10,"d":"1.09E-10"},"1.0,1.0","0.873,0.908",0.109]
[6324,"ENSG00000163939.18","PBRM1","chr3","-",52679573,52679726,52679573,52679723,52682091,52682233,6324,"58,50","14,14","29,27","7,2",152,149,0.166629511865,0.383849594971234,"0.802,0.778","0.802,0.93",-0.076]
[6345,"ENSG00000245694.9","CRNDE","chr16","-",54920297,54920410,54920297,54920338,54923584,54923650,6345,524501,"16,11",125130,"6,17",221,149,0.00034095675018,1.79072471769647E-3,"0.957,0.968","0.934,0.838",0.076]
[6357,"ENSG00000127870.16","RNF6","chr13","-",26218510,26218606,26218510,26218588,26219456,26219667,6357,305222,"7,1",307306,"0,1",167,149,0.707926542614,1,"0.975,0.995","1.0,0.996",-0.013]
[6387,"ENSG00000129255.15","MPDU1","chr17","+",7586898,7587271,7587160,7587271,7585731,7585797,6387,"49,60","0,0","20,32","0,1",298,149,1,1,"1.0,1.0","1.0,0.941",0.03]
[6405,"ENSG00000172053.17","QARS","chr3","-",49098191,49098258,49098191,49098251,49098352,49098480,6405,19561968,"0,0",8341017,"2,0",156,149,1,1,"1.0,1.0","0.997,1.0",2E-3]
[6421,"ENSG00000206535.7","LNP1","chr3","+",100451679,100451949,100451718,100451949,100429696,100429885,6421,"0,0","32,31","2,3","35,39",188,149,0.0844820691103,0.222133734664463,"0.0,0.0","0.043,0.057",-0.05]
[6432,"ENSG00000005302.18","MSL3","chrX","+",11765466,11765729,11765521,11765729,11763779,11763938,6432,221177,"1,3",188198,"0,0",204,149,0.83936080019,1,"0.994,0.977","1.0,1.0",-0.014]
[6447,"ENSG00000114388.12","NPRL2","chr3","-",50349385,50349494,50349385,50349490,50349664,50349828,6447,221198,"10,15","77,80","11,13",153,149,4.52070697692E-3,0.0180328152763817,"0.956,0.928","0.872,0.857",0.077]
[6479,"ENSG00000125450.10","NUP85","chr17","+",75226050,75226157,75226055,75226157,75225697,75225829,6479,625663,"17,10",331304,"8,9",154,149,0.589245406323,0.979673647681764,"0.973,0.985","0.976,0.97",0.006]
[6486,"ENSG00000187147.17","RNF220","chr1","+",44649882,44651723,44650703,44651723,44649660,44649769,6486,773783,"8,2",733836,"102,83",298,149,0,0,"0.98,0.995","0.782,0.834",0.179]
[6503,"ENSG00000138443.15","ABI2","chr2","+",203395655,203395780,203395658,203395780,203391045,203391143,6503,"7,6","0,0","93,89","10,7",152,149,0.00211380782003,0.00920199908215684,"1.0,1.0","0.901,0.926",0.087]
[6555,"ENSG00000143595.12","AQP10","chr1","+",154323588,154325325,154324281,154325325,154323240,154323359,6555,"85,66","0,0","52,76","3,8",298,149,{"v":1.03776115605e-05,"d":"1.04E-05"},{"v":7.25033973641335e-05,"d":"7.25E-05"},"1.0,1.0","0.897,0.826",0.139]
[6558,"ENSG00000214655.10","ZSWIM8","chr10","+",73794540,73794639,73794555,73794639,73794146,73794330,6558,"54,75","25,45","35,52","39,8",164,149,0.687751729327,1,"0.662,0.602","0.449,0.855",-0.02]
[6575,"ENSG00000114491.13","UMPS","chr3","+",124737567,124738239,124737914,124738239,124730451,124730627,6575,505438,"0,0",485585,"0,4",298,149,1,1,"1.0,1.0","1.0,0.987",0.006]
[6593,"ENSG00000163608.14","NEPRO","chr3","-",113011044,113011406,113011044,113011165,113013948,113014032,6593,321241,"1,0",209193,"0,0",298,149,1,1,"0.994,1.0","1.0,1.0",-0.003]
[6616,"ENSG00000100897.17","DCAF11","chr14","+",24116971,24117044,24116987,24117044,24115381,24115749,6616,"50,87","4,3","54,58","0,0",165,149,0.0124549437632,0.0436186016166459,"0.919,0.963","1.0,1.0",-0.059]
[6637,"ENSG00000114745.13","GORASP1","chr3","-",39098740,39098893,39098740,39098853,39099352,39099503,6637,177243,"12,3",357360,"14,17",189,149,0.461383729445,0.835244546668278,"0.921,0.985","0.953,0.943",0.005]
[6666,"ENSG00000137522.17","RNF121","chr11","+",71982760,71982915,71982806,71982915,71960749,71960891,6666,192182,"5,7","53,45","3,3",195,149,0.513467934348,0.899680874613979,"0.967,0.952","0.931,0.92",0.034]
[6681,"ENSG00000205639.10","MFSD2B","chr2","+",24023129,24023726,24023582,24023726,24022821,24022902,6681,"20,36","8,7","0,6","3,2",298,149,0.0587537065281,0.164165932694586,"0.556,0.72","0.0,0.6",0.338]
[6711,"ENSG00000119862.12","LGALSL","chr2","+",64456267,64456465,64456287,64456465,64455588,64455677,6711,"2,0","5,0","0,0","5,7",169,149,1,1,"0.261,NA","0.0,0.0",0.261]
[6731,"ENSG00000198522.13","GPN1","chr2","+",27629858,27629952,27629868,27629952,27629051,27629169,6731,430395,"1,1",354396,"0,0",159,149,1,1,"0.998,0.997","1.0,1.0",-2E-3]
[6750,"ENSG00000144567.10","RETREG2","chr2","+",219180109,219180245,219180197,219180245,219179732,219179763,6750,290315,"15,20",376362,"18,18",237,149,0.535656934593,0.927003956297944,"0.924,0.908","0.929,0.927",-0.012]
[6777,"ENSG00000132635.16","PCED1A","chr20","-",2836038,2836314,2836038,2836110,2838231,2838478,6777,870943,"4,10",361360,"7,5",298,149,0.10085359578,0.25679424924886,"0.991,0.979","0.963,0.973",0.017]
[6791,"ENSG00000127586.16","CHTF18","chr16","+",794039,794201,794053,794201,793143,793274,6791,"2,5",263327,"0,0",84129,163,149,1,1,"0.007,0.014","0.0,0.0",0.011]
[6810,"ENSG00000138964.16","PARVG","chr22","+",44181741,44181917,44181863,44181917,44181399,44181431,6810,370377,"0,2",95134,"0,0",271,149,1,1,"1.0,0.99","1.0,1.0",-0.005]
[6838,"ENSG00000244306.11","DUXAP10","chr14","-",19331834,19331972,19331834,19331948,19333701,19333813,6838,"11,2","56,71","2,2","24,14",173,149,0.72825774342,1,"0.145,0.024","0.067,0.11",-0.004]
[6852,"ENSG00000197530.12","MIB2","chr1","+",1625545,1626754,1626649,1626754,1625285,1625428,6852,121140,"7,2","97,93","4,0",298,149,0.248515876992,0.527801009552764,"0.896,0.972","0.924,1.0",-0.028]
[6884,"ENSG00000004777.18","ARHGAP33","chr19","+",35786412,35787072,35786895,35787072,35785408,35785483,6884,82125,"1,1","44,63","0,0",298,149,1,1,"0.976,0.984","1.0,1.0",-0.02]
[6891,"ENSG00000113761.11","ZNF346","chr5","+",177044388,177044533,177044391,177044533,177041125,177041229,6891,"0,2","0,0","3,1","2,2",152,149,1,1,"NA,1.0","0.595,0.329",0.538]
[6926,"ENSG00000138449.10","SLC40A1","chr2","-",189580417,189580562,189580417,189580524,189581707,189582031,6926,10591017,"5,20",875988,"90,71",187,149,0,0,"0.994,0.976","0.886,0.917",0.084]
[6943,"ENSG00000063046.17","EIF4B","chr12","+",53021715,53021860,53021805,53021860,53019909,53020026,6943,"69,68",36553394,73108,41224348,239,149,0.579068425182,0.970732656162184,"0.012,0.012","0.011,0.015",-1E-3]
[6959,"ENSG00000121152.9","NCAPH","chr2","+",96341674,96341894,96341713,96341894,96335800,96335848,6959,228215,"33,55","63,64","5,1",188,149,{"v":3.5541137289e-05,"d":"3.55E-05"},2.2724953857955E-4,"0.846,0.756","0.909,0.981",-0.144]
[6995,"ENSG00000144034.14","TPRKB","chr2","-",73734428,73734591,73734428,73734588,73737301,73737400,6995,301252,94103,263302,80160,152,149,0.460010873219,0.833661618323648,"0.758,0.706","0.763,0.649",0.026]
[7014,"ENSG00000135637.13","CCDC142","chr2","-",74480955,74481086,74480955,74481065,74481222,74481372,7014,"38,42","4,10","16,17","1,0",170,149,0.000655187009703,0.00323806071005183,"0.893,0.786","0.933,1.0",-0.127]
[7028,"ENSG00000101751.10","POLI","chr18","+",54277702,54277855,54277771,54277855,54273925,54274090,7028,"62,59","3,2","63,55","3,0",218,149,0.344038660576,0.674175948052166,"0.934,0.953","0.935,1.0",-0.024]
[7058,"ENSG00000115525.17","ST3GAL5","chr2","-",85847860,85848381,85847860,85848204,85851263,85851703,7058,"6,5","10,0","12,21","7,1",298,149,0.757276876731,1,"0.231,1.0","0.462,0.913",-0.072]
[7076,"ENSG00000132300.18","PTCD3","chr2","+",86133177,86133436,86133345,86133436,86132317,86132424,7076,784778,"1,6",524532,"1,5",298,149,1,1,"0.997,0.985","0.996,0.982",2E-3]
[7097,"ENSG00000050748.17","MAPK9","chr5","-",180233593,180236531,180233593,180236526,180238331,180238403,7097,"83,56",313250,"43,32",108134,154,149,0.274931511313,0.570508476922006,"0.204,0.178","0.278,0.188",-0.042]
[7116,"ENSG00000124155.17","PIGT","chr20","+",45419503,45419590,45419507,45419590,45419294,45419395,7116,755625,"2,1",704652,"5,22",153,149,0.0100051849974,0.0359190472655576,"0.997,0.998","0.993,0.967",0.018]
[7134,"ENSG00000143851.15","PTPN7","chr1","-",202159280,202159454,202159280,202159450,202160544,202161581,7134,490443,"5,3",484540,"1,10",153,149,0.837837166841,1,"0.99,0.993","0.998,0.981",2E-3]
[7154,"ENSG00000127980.15","PEX1","chr7","-",92501506,92502079,92501506,92501673,92503040,92503195,7154,74100,"0,15","9,12","19,58",298,149,0,0,"1.0,0.769","0.191,0.094",0.742]
[7175,"ENSG00000179091.4","CYC1","chr8","+",144096123,144096250,144096142,144096250,144095026,144095228,7175,164192,"0,0","81,83","0,2",168,149,1,1,"1.0,1.0","1.0,0.974",0.013]
[7200,"ENSG00000165699.14","TSC1","chr9","-",132943467,132943706,132943467,132943654,132944571,132944769,7200,"7,1","0,0","7,14","2,0",201,149,0.683218801347,1,"1.0,1.0","0.722,1.0",0.139]
[7223,"ENSG00000163006.11","CCDC138","chr2","+",108791554,108791802,108791711,108791802,108788851,108788966,7223,"47,72","5,0","34,32","1,8",298,149,0.0794752569124,0.211789301277163,"0.825,1.0","0.944,0.667",0.107]
[7258,"ENSG00000144161.12","ZC3H8","chr2","-",112231837,112231947,112231837,112231945,112233259,112233371,7258,267218,"1,4",308273,"5,10",151,149,0.0452593022757,0.131928082169553,"0.996,0.982","0.984,0.964",0.015]
[7259,"ENSG00000166783.21","MARF1","chr16","-",15622933,15623123,15622933,15623057,15624768,15624927,7259,107119,"0,0","58,66","6,7",215,149,{"v":8.74573670373e-07,"d":"8.75E-07"},{"v":7.25283944840328e-06,"d":"7.25E-06"},"1.0,1.0","0.87,0.867",0.131]
[7280,"ENSG00000182093.15","WRB","chr21","+",39405913,39406731,39406561,39406731,39393165,39393280,7280,"24,24","1,0","27,38","0,0",298,149,1,1,"0.923,1.0","1.0,1.0",-0.038]
[7298,"ENSG00000127463.14","EMC1","chr1","-",19219568,19219698,19219568,19219669,19220763,19220848,7298,553608,"15,25",704802,"19,29",178,149,0.782610837847,1,"0.969,0.953","0.969,0.959",-0.003]
[7316,"ENSG00000227372.12","TP73-AS1","chr1","-",3745606,3746186,3745606,3746181,3746436,3747023,7316,"25,28","4,0","57,65","6,2",154,149,0.756373770598,1,"0.858,1.0","0.902,0.969",-0.006]
[7344,"ENSG00000250167.1","AC034206.1","chr5","+",135629236,135629376,135629239,135629376,135601049,135601203,7344,"43,17","1,0","14,31","3,0",152,149,0.404460282357,0.762489002406592,"0.977,1.0","0.821,1.0",0.078]
[7367,"ENSG00000130396.20","AFDN","chr6","+",167872213,167872377,167872216,167872377,167870382,167870498,7367,"33,36","18,15","21,32","10,22",152,149,0.49734536845,0.880299805813525,"0.642,0.702","0.673,0.588",0.041]
[7386,"ENSG00000171777.15","RASGRP4","chr19","-",38417051,38417168,38417051,38417166,38418390,38418564,7386,193214,"4,7",107103,"3,0",151,149,0.119804021771,0.29482306150678,"0.979,0.968","0.972,1.0",-0.012]
[7415,"ENSG00000105193.8","RPS16","chr19","-",39433521,39433761,39433521,39433569,39435606,39435708,7415,3107331915,"0,2",3149133932,"5,2",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[7456,"ENSG00000128654.13","MTX2","chr2","+",176329300,176329426,176329369,176329426,176328873,176328912,7456,13671107,"3,8",321411,"0,8",218,149,0.85395323399,1,"0.997,0.99","1.0,0.972",0.008]
[7491,"ENSG00000128694.11","OSGEPL1","chr2","-",189746659,189747331,189746659,189747168,189752652,189752724,7491,"102,98","1,0",157131,"0,0",298,149,1,1,"0.981,1.0","1.0,1.0",-0.01]
[7532,"ENSG00000155749.12","ALS2CR12","chr2","-",201289695,201289859,201289695,201289785,201299237,201299300,7532,"2,0","12,11","0,1","0,0",223,149,1,1,"0.1,0.0","NA,1.0",-0.95]
[7555,"ENSG00000105185.11","PDCD5","chr19","+",32584949,32585011,32584954,32585011,32582194,32582232,7555,37033599,"27,50",23912620,"39,28",154,149,0.265690165811,0.555215826394184,"0.993,0.986","0.983,0.989",0.004]
[7574,"ENSG00000003756.16","RBM5","chr3","+",50100531,50103166,50103082,50103166,50099981,50100051,7574,232229,"49,36",263194,"47,51",298,149,0.416258363569,0.779239415141696,"0.703,0.761","0.737,0.655",0.036]
[7602,"ENSG00000055332.17","EIF2AK2","chr2","-",37148856,37149257,37148856,37149023,37156907,37157047,7602,"24,14","51,38","65,27","29,34",298,149,0.00164569609421,7.36919962704294E-3,"0.19,0.156","0.528,0.284",-0.233]
[7613,"ENSG00000109911.18","ELP4","chr11","+",31603764,31603907,31603767,31603907,31594769,31594901,7613,"24,33",125134,"21,29","71,73",152,149,0.062741841675,0.17332381512684,"0.158,0.194","0.225,0.28",-0.077]
[7638,"ENSG00000100650.15","SRSF5","chr14","+",69769181,69770540,69770466,69770540,69768797,69768896,7638,51054634,"0,1",40124205,"25,24",298,149,0.516582246006,0.903229299204671,"1.0,1.0","0.988,0.989",0.012]
[7652,"ENSG00000160058.18","BSDC1","chr1","-",32383829,32383997,32383829,32383906,32386778,32386895,7652,486541,"1,0",937894,"1,2",240,149,1,1,"0.997,1.0","0.998,0.996",1E-3]
[7682,"ENSG00000178752.15","ERFE","chr2","+",238167871,238168875,238168370,238168875,238165605,238165684,7682,"1,0","4,0","3,11","1,0",298,149,1,1,"0.111,NA","0.6,1.0",-0.689]
[7703,"ENSG00000166411.13","IDH3A","chr15","+",78156907,78157631,78157572,78157631,78155212,78155275,7703,"91,89","0,4","67,67","0,0",298,149,0.345552088782,0.676502236135298,"1.0,0.918","1.0,1.0",-0.041]
[7715,"ENSG00000160410.14","SHKBP1","chr19","+",40578122,40578212,40578153,40578212,40577556,40577630,7715,"8,8",524553,"10,4",405344,180,149,0.627151117768,1,"0.012,0.012","0.02,0.01",-0.003]
[7737,"ENSG00000105698.15","USF2","chr19","+",35270717,35270805,35270758,35270805,35269580,35269699,7737,216214,"17,7",288273,"8,5",190,149,0.0116139516595,0.0409783161088805,"0.909,0.96","0.966,0.977",-0.037]
[7758,"ENSG00000225077.3","LINC00337","chr1","+",6237469,6237848,6237813,6237848,6237244,6237345,7758,"14,39","8,13","5,10","5,4",298,149,0.448825680629,0.818946395919977,"0.467,0.6","0.333,0.556",0.089]
[7780,"ENSG00000198520.11","ARMH1","chr1","+",44725032,44725217,44725135,44725217,44724761,44724839,7780,"85,85","23,16","73,80","14,13",252,149,0.355837668956,0.69015444458663,"0.686,0.759","0.755,0.784",-0.047]
[7799,"ENSG00000168036.17","CTNNB1","chr3","+",41235723,41235843,41235726,41235843,41234138,41234297,7799,10601061,"8,7",12521259,"15,3",152,149,1,1,"0.992,0.993","0.988,0.998",-1E-3]
[7829,"ENSG00000133624.13","ZNF767P","chr7","-",149552800,149553016,149552800,149553013,149619923,149620037,7829,"2,4","2,0","0,0","0,2",152,149,1,1,"0.495,1.0","NA,0.0",0.748]
[7849,"ENSG00000088038.18","CNOT3","chr19","+",54142925,54143003,54142928,54143003,54137761,54137993,7849,66115,322343,"94,78",335367,152,149,0.588546029963,0.979122883512426,"0.167,0.247","0.216,0.172",0.013]
[7874,"ENSG00000142676.14","RPL11","chr1","+",23694659,23695908,23695797,23695908,23693806,23693913,7874,2725624094,"17,5",2714529409,"18,17",298,149,1,1,"0.999,1.0","0.999,0.999",1E-3]
[7889,"ENSG00000096384.19","HSP90AB1","chr6","+",44248616,44248776,44248629,44248776,44247086,44247195,7889,"108,56",1469212630,91130,1170211637,162,149,1,1,"0.007,0.004","0.007,0.01",-0.003]
[7912,"ENSG00000172046.18","USP19","chr3","-",49117656,49117830,49117656,49117785,49117946,49118120,7912,142185,"51,63",117102,"7,15",194,149,{"v":7.87046495532e-07,"d":"7.87E-07"},{"v":6.57961349541015e-06,"d":"6.58E-06"},"0.681,0.693","0.928,0.839",-0.196]
[7929,"ENSG00000110080.18","ST3GAL4","chr11","+",126407233,126407349,126407251,126407349,126406942,126407023,7929,"10,8",446384,"3,0",187229,167,149,0.0862966485912,0.225475143908891,"0.02,0.018","0.014,0.0",0.012]
[7946,"ENSG00000124357.12","NAGK","chr2","+",71072640,71073594,71073481,71073594,71071685,71071827,7946,245208,"0,0",161188,"2,1",298,149,0.628508658239,1,"1.0,1.0","0.976,0.989",0.018]
[7950,"ENSG00000124357.12","NAGK","chr2","+",71077557,71077636,71077569,71077636,71076603,71076701,7950,211189,"2,2",153141,"0,0",161,149,1,1,"0.99,0.989","1.0,1.0",-0.01]
[7990,"ENSG00000075711.20","DLG1","chr3","-",197076585,197076685,197076585,197076682,197081050,197081117,7990,95101,"23,25","10,25","3,1",152,149,0.0531314234892,0.151000306715536,"0.802,0.798","0.766,0.961",-0.063]
[8010,"ENSG00000059691.11","GATB","chr4","-",151716875,151717074,151716875,151717001,151719424,151719538,8010,389390,"0,0",405429,"0,1",222,149,1,1,"1.0,1.0","1.0,0.997",2E-3]
[8016,"ENSG00000204120.14","GIGYF2","chr2","+",232791257,232791446,232791260,232791446,232791007,232791170,8016,390377,"7,7",347375,"6,11",152,149,0.494668455743,0.876744069988608,"0.982,0.981","0.983,0.971",0.005]
[8049,"ENSG00000169727.12","GPS1","chr17","+",82055161,82055222,82055164,82055222,82054897,82054975,8049,10251039,191211,735860,154139,152,149,0.666272314179,1,"0.84,0.828","0.824,0.858",-0.007]
[8070,"ENSG00000142945.12","KIF2C","chr1","+",44750308,44750564,44750441,44750564,44747651,44747700,8070,"18,11",15531571,"11,13",705700,282,149,1,1,"0.006,0.004","0.008,0.01",-0.004]
[8079,"ENSG00000164744.12","SUN3","chr7","-",47987150,47987449,47987150,47987360,47988787,47988880,8079,"15,0","1,0","0,4","0,0",238,149,1,1,"0.904,NA","NA,1.0",-0.096]
[8113,"ENSG00000161618.9","ALDH16A1","chr19","+",49465737,49465905,49465780,49465905,49464631,49464762,8113,379430,"3,4",600594,"17,17",192,149,0.000701674472307,3.44318721824967E-3,"0.99,0.988","0.965,0.964",0.025]
[8114,"ENSG00000064115.10","TM7SF3","chr12","-",26999525,26999676,26999525,26999648,27003235,27003390,8114,784797,"25,14",119121,"12,0",177,149,0.162468234815,0.376775467371586,"0.964,0.98","0.893,1.0",0.025]
[8144,"ENSG00000167965.17","MLST8","chr16","+",2206478,2206659,2206483,2206659,2206357,2206409,8144,"11,3","6,16","13,6","11,10",154,149,0.59537502395,0.987094177052648,"0.639,0.154","0.533,0.367",-0.053]
[8151,"ENSG00000167965.17","MLST8","chr16","+",2208209,2208613,2208449,2208613,2207192,2207345,8151,606572,"10,13",400465,"41,50",298,149,{"v":4.36317648678e-13,"d":"4.36E-13"},{"v":7.79823763035916e-12,"d":"7.80E-12"},"0.968,0.957","0.83,0.823",0.136]
[8174,"ENSG00000106077.18","ABHD11","chr7","-",73738327,73738463,73738327,73738442,73738645,73738852,8174,"80,90","1,1",126117,"0,0",170,149,1,1,"0.986,0.987","1.0,1.0",-0.014]
[8204,"ENSG00000157600.11","TMEM164","chrX","+",110003500,110004164,110003882,110004164,110003114,110003178,8204,123137,"3,3",178143,"7,2",298,149,0.652968662591,1,"0.953,0.958","0.927,0.973",0.006]
[8211,"ENSG00000005471.17","ABCB4","chr7","-",87406287,87406515,87406287,87406494,87408036,87408234,8211,"4,3","0,0","0,0","0,2",170,149,1,1,"1.0,1.0","NA,0.0",1]
[8263,"ENSG00000137807.15","KIF23","chr15","+",69444789,69445041,69444810,69445041,69440767,69441079,8263,176140,"18,17",558506,"20,19",170,149,{"v":5.09978176958E-5,"d":"5.10E-05"},0.00031561559862035,"0.896,0.878","0.961,0.959",-0.073]
[8267,"ENSG00000158560.14","DYNC1I1","chr7","+",95813195,95813337,95813246,95813337,95810391,95810506,8267,"1,0","115,92","5,2","48,52",200,149,0.0177039593266,0.059153478926468,"0.006,0.0","0.072,0.028",-0.047]
[8301,"ENSG00000066923.17","STAG3","chr7","+",100188452,100189016,100188811,100189016,100186199,100186296,8301,"0,2","0,0","2,0","1,1",298,149,1,1,"NA,1.0","0.5,0.0",0.75]
[8316,"ENSG00000154611.14","PSMA8","chr18","+",26151839,26151982,26151857,26151982,26144558,26144685,8316,"1,0","33,52","0,3","18,4",167,149,0.16305107877,0.377750662295175,"0.026,0.0","0.0,0.401",-0.188]
[8338,"ENSG00000105821.14","DNAJC2","chr7","-",103323597,103323663,103323597,103323625,103324481,103324562,8338,936862,"0,0",830754,"7,7",187,149,0.896001728753,1,"1.0,1.0","0.99,0.988",0.011]
[8359,"ENSG00000091140.13","DLD","chr7","+",107906266,107906368,107906270,107906368,107905360,107905504,8359,860737,"16,15",907932,"13,8",153,149,0.0723037526048,0.195696808208748,"0.981,0.98","0.985,0.991",-0.008]
[8383,"ENSG00000128573.24","FOXP2","chr7","+",114631527,114631705,114631530,114631705,114629864,114630005,8383,"30,45","2,1","44,28","7,3",152,149,0.0196555721384,0.0646070787727908,"0.936,0.978","0.86,0.901",0.077]
[8421,"ENSG00000163820.14","FYCO1","chr3","-",45917903,45921840,45917903,45919065,45923655,45923765,8421,"65,65","1,0","50,58","0,0",298,149,1,1,"0.97,1.0","1.0,1.0",-0.015]
[8441,"ENSG00000140521.13","POLG","chr15","-",89319227,89319408,89319227,89319350,89320765,89321012,8441,"27,18",609725,"73,47",511600,207,149,{"v":3.00555058619e-09,"d":"3.01E-09"},{"v":3.47629442277178E-8,"d":"3.48E-08"},"0.031,0.018","0.093,0.053",-0.048]
[8462,"ENSG00000116001.15","TIA1","chr2","-",70214348,70214494,70214348,70214491,70215370,70215494,8462,772657,138108,224262,"45,34",152,149,0.693673076627,1,"0.846,0.856","0.83,0.883",-0.006]
[8484,"ENSG00000157764.13","BRAF","chr7","-",140794307,140794467,140794307,140794415,140800361,140800481,8484,121106,"0,0",131119,"2,2",201,149,0.543478838073,0.933914215528261,"1.0,1.0","0.98,0.978",0.021]
[8508,"ENSG00000158805.11","ZNF276","chr16","+",89723259,89723709,89723278,89723709,89723136,89723183,8508,265212,"39,29",194184,"28,27",168,149,0.948161261628,1,"0.858,0.866","0.86,0.858",0.003]
[8539,"ENSG00000157353.16","FUK","chr16","+",70474128,70474339,70474134,70474339,70472982,70473353,8539,"18,28","0,1","38,41","2,2",155,149,0.143432575919,0.340827034984603,"1.0,0.964","0.948,0.952",0.032]
[8567,"ENSG00000106290.14","TAF6","chr7","-",100113348,100113769,100113348,100113405,100113867,100113954,8567,429529,"2,0",163152,"74,94",298,149,0,0,"0.991,1.0","0.524,0.447",0.51]
[8588,"ENSG00000256683.6","ZNF350","chr19","-",51969004,51969145,51969004,51969131,51974345,51974531,8588,"3,4","90,72","9,4",165159,163,149,0.824904150199,1,"0.03,0.048","0.047,0.022",0.004]
[8615,"ENSG00000165792.17","METTL17","chr14","+",20993117,20994063,20993968,20994063,20992091,20992205,8615,"81,50","0,0",166155,"3,0",298,149,0.566183951691,0.958041932538964,"1.0,1.0","0.965,1.0",0.018]
[8627,"ENSG00000036672.15","USP2","chr11","-",119359023,119359342,119359023,119359134,119359536,119359660,8627,"22,10","0,0","21,24","2,0",298,149,0.814650438221,1,"1.0,1.0","0.84,1.0",0.08]
[8654,"ENSG00000154760.13","SLFN13","chr17","-",35444614,35445693,35444614,35444701,35447267,35447414,8654,166129,"7,4",128132,"21,43",298,149,{"v":2.6847664758e-08,"d":"2.68E-08"},{"v":2.7761556588291e-07,"d":"2.78E-07"},"0.922,0.942","0.753,0.606",0.252]
[8664,"ENSG00000173020.10","GRK2","chr11","+",67281821,67282542,67282434,67282542,67281649,67281728,8664,18852079,"0,3",14471616,"2,0",298,149,1,1,"1.0,0.997","0.997,1.0",0]
[8698,"ENSG00000120093.11","HOXB3","chr17","-",48552026,48552632,48552026,48552360,48555530,48555618,8698,"100,85","2,4",171226,"7,7",298,149,0.628046150668,1,"0.962,0.914","0.924,0.942",0.005]
[8718,"ENSG00000166997.7","CNPY4","chr7","+",100124431,100124631,100124513,100124631,100122783,100122906,8718,"5,1","50,43","22,21","18,19",231,149,{"v":1.32005517628E-13,"d":"1.32E-13"},{"v":2.47674605811991e-12,"d":"2.48E-12"},"0.061,0.015","0.441,0.416",-0.391]
[8727,"ENSG00000104365.14","IKBKB","chr8","+",42317656,42317771,42317709,42317771,42316709,42316904,8727,508557,"29,18",459489,"36,38",202,149,0.00708267763211,0.0267106164634325,"0.928,0.958","0.904,0.905",0.038]
[8770,"ENSG00000133731.9","IMPA1","chr8","-",81680649,81680783,81680649,81680779,81681497,81681584,8770,388417,"27,16",346405,"33,43",153,149,0.00298682853088,0.0125543684777434,"0.933,0.962","0.911,0.902",0.041]
[8794,"ENSG00000205133.11","TRIQK","chr8","-",92916928,92917010,92916928,92917007,92954405,92954564,8794,"69,82","34,31","120,96","31,39",152,149,0.230586621721,0.496818616246363,"0.665,0.722","0.791,0.707",-0.055]
[8805,"ENSG00000138346.14","DNA2","chr10","-",68430435,68430660,68430435,68430540,68431856,68431971,8805,266211,"14,2",117109,"0,1",269,149,0.00121155939546,0.00561310729974848,"0.913,0.983","1.0,0.984",-0.044]
[8838,"ENSG00000102805.14","CLN5","chr13","+",76995842,76996127,76995901,76996127,76995456,76995513,8838,"14,8","12,7","23,11","12,17",208,149,0.961193056603,1,"0.455,0.45","0.579,0.317",0.005]
[8855,"ENSG00000126602.10","TRAP1","chr16","-",3674338,3674597,3674338,3674494,3675323,3675397,8855,78112,23352664,"38,31",534628,252,149,0.0165260439653,0.0556663211227591,"0.019,0.024","0.04,0.028",-0.013]
[8875,"ENSG00000129292.20","PHF20L1","chr8","+",132804580,132804740,132804614,132804740,132803818,132804032,8875,"1,3",229228,"9,13",202282,183,149,0.00059233027739,0.00296093730584404,"0.004,0.011","0.035,0.036",-0.028]
[8902,"ENSG00000158106.13","RHPN1","chr8","+",143380064,143380783,143380588,143380783,143379828,143379985,8902,"17,21","2,0","28,20","0,0",298,149,0.853259821228,1,"0.81,1.0","1.0,1.0",-0.095]
[8921,"ENSG00000104529.17","EEF1D","chr8","-",143590607,143590738,143590607,143590735,143597347,143597415,8921,"7,4","3,0","11,7","3,3",152,149,0.438873295618,0.807717763106985,"0.696,1.0","0.782,0.696",0.109]
[8940,"ENSG00000179832.17","MROH1","chr8","+",144242210,144242515,144242368,144242515,144241394,144241517,8940,"3,11","101,92","4,15","18,19",298,149,{"v":3.48433436821e-05,"d":"3.48E-05"},0.00022330436565352,"0.015,0.056","0.1,0.283",-0.156]
[8960,"ENSG00000107099.15","DOCK8","chr9","+",368017,370300,370229,370300,340158,340321,8960,417570,"0,0",287350,"1,0",298,149,1,1,"1.0,1.0","0.993,1.0",0.004]
[8983,"ENSG00000214719.11","SMURF2P1-LRRC37BP1","chr17","+",30610888,30610942,30610893,30610942,30608429,30608562,8983,196180,"4,0",142137,"7,4",154,149,0.0141754567517,0.0488599596183907,"0.979,1.0","0.952,0.971",0.028]
[9016,"ENSG00000139697.13","SBNO1","chr12","-",123345257,123345570,123345257,123345567,123348028,123348133,9016,98114,168141,137132,163160,152,149,0.24244884349,0.517536231418937,"0.364,0.442","0.452,0.447",-0.046]
[9017,"ENSG00000139697.13","SBNO1","chr12","-",123345257,123345570,123345257,123345567,123350309,123350441,9017,"8,19","4,6","22,15","5,9",152,149,0.843251162266,1,"0.662,0.756","0.812,0.62",-0.007]
[9036,"ENSG00000223839.7","FAM95B1","chr9","+",40324888,40325092,40324984,40325092,40324550,40324802,9036,"0,0","0,3","0,1","6,4",245,149,1,1,"NA,0.0","0.0,0.132",-0.066]
[9056,"ENSG00000161513.11","FDXR","chr17","-",74872035,74872133,74872035,74872107,74872242,74873006,9056,"25,41","0,0","33,36","0,2",175,149,0.347926905683,0.678428833489094,"1.0,1.0","1.0,0.939",0.03]
[9077,"ENSG00000107372.12","ZFAND5","chr9","-",72360627,72360787,72360627,72360784,72364695,72365235,9077,"83,80","4,2",295303,"4,7",152,149,0.462546312921,0.836618663697677,"0.953,0.975","0.986,0.977",-0.018]
[9095,"ENSG00000111321.10","LTBR","chr12","+",6385021,6385147,6385036,6385147,6384587,6384684,9095,659655,"23,23",762825,"61,70",164,149,{"v":8.01873652811e-06,"d":"8.02E-06"},{"v":5.70810146159795e-05,"d":"5.71E-05"},"0.963,0.963","0.919,0.915",0.046]
[9120,"ENSG00000149499.11","EML3","chr11","-",62603943,62604201,62603943,62604041,62605112,62605180,9120,184203,"0,0",197198,"8,2",298,149,0.00238814520805,0.0102829118433845,"1.0,1.0","0.925,0.98",0.047]
[9139,"ENSG00000123349.13","PFDN5","chr12","+",53296429,53297924,53297849,53297924,53295838,53295941,9139,109117,"13,29","50,69","7,4",298,149,0.0587172976478,0.16411949760472,"0.807,0.669","0.781,0.896",-0.101]
[9172,"ENSG00000153037.14","SRP19","chr5","+",112864433,112864528,112864456,112864528,112862507,112862583,9172,"3,1",579500,"6,4",423471,172,149,1,1,"0.004,0.002","0.012,0.007",-0.006]
[9206,"ENSG00000167118.10","URM1","chr9","+",128389260,128392016,128389665,128392016,128387815,128387897,9206,8901017,"0,0",14231513,"0,5",298,149,1,1,"1.0,1.0","1.0,0.993",0.004]
[9219,"ENSG00000242802.7","AP5Z1","chr7","+",4790672,4790887,4790809,4790887,4789831,4789929,9219,196197,"14,4",350391,"9,2",286,149,0.0045350447219,0.0180813105186138,"0.879,0.962","0.953,0.99",-0.051]
[9236,"ENSG00000126883.16","NUP214","chr9","+",131146128,131146304,131146161,131146304,131144279,131144754,9236,111171,"24,47","102,79","15,13",182,149,0.0496280863873,0.14246551161134,"0.791,0.749","0.848,0.833",-0.071]
[9274,"ENSG00000244187.7","TMEM141","chr9","+",136791946,136792358,136792250,136792358,136791710,136791777,9274,485536,"33,35",128131,"14,25",298,149,1.90657975019E-3,0.00840562017231688,"0.88,0.884","0.821,0.724",0.11]
[9283,"ENSG00000054148.17","PHPT1","chr9","+",136850502,136850560,136850505,136850560,136850012,136850137,9283,"23,33","29,48","31,16","65,51",152,149,0.0270394319206,0.0847460351162266,"0.437,0.403","0.319,0.235",0.143]
[9312,"ENSG00000113108.19","APBB3","chr5","-",140561586,140561722,140561586,140561701,140562099,140562227,9312,"5,8","14,9","6,9","13,3",170,149,0.346115506998,0.677285488328082,"0.238,0.438","0.288,0.724",-0.168]
[9351,"ENSG00000197647.11","ZNF433","chr19","-",12018165,12018301,12018165,12018292,12030139,12030198,9351,"5,10","5,1","4,5","1,0",158,149,0.00549564922719,0.0213818826340967,"0.485,0.904","0.79,1.0",-0.201]
[9366,"ENSG00000120539.14","MASTL","chr10","+",27173117,27173259,27173120,27173259,27169943,27171083,9366,"131,89",148113,"63,70","77,75",152,149,0.827430779616,1,"0.465,0.436","0.445,0.478",-0.011]
[9386,"ENSG00000112511.17","PHF1","chr6","+",33415589,33415670,33415592,33415670,33415260,33415329,9386,195181,"15,10",250287,"14,11",152,149,0.268036868547,0.558780731739635,"0.927,0.947","0.946,0.962",-0.017]
[9404,"ENSG00000226688.6","ENTPD1-AS1","chr10","-",95904829,95904938,95904829,95904935,95950457,95950528,9404,"3,3","2,0","2,1","1,0",152,149,0.543937906481,0.934140801161454,"0.595,1.0","0.662,1.0",-0.033]
[9440,"ENSG00000076513.16","ANKRD13A","chr12","+",110027704,110027766,110027707,110027766,110025741,110025823,9440,332277,"89,51","76,31","17,9",152,149,0.828617125238,1,"0.785,0.842","0.814,0.772",0.021]
[9462,"ENSG00000102225.15","CDK16","chrX","+",47227159,47227223,47227180,47227223,47226993,47227099,9462,"20,10",886746,"18,15",517548,170,149,0.0615414287111,0.170689989398378,"0.019,0.012","0.03,0.023",-0.011]
[9479,"ENSG00000162063.12","CCNF","chr16","+",2449110,2449462,2449281,2449462,2448854,2448978,9479,"6,3",268292,"29,34",253231,298,149,{"v":1.40508715774e-11,"d":"1.41E-11"},{"v":2.08078353556032e-10,"d":"2.08E-10"},"0.011,0.005","0.054,0.069",-0.053]
[9505,"ENSG00000197283.16","SYNGAP1","chr6","+",33447829,33447932,33447842,33447932,33446574,33446786,9505,113116,239258,108158,224257,162,149,0.237883763414,0.509891457739028,"0.303,0.293","0.307,0.361",-0.036]
[9524,"ENSG00000092020.10","PPP2R3C","chr14","-",35110524,35110650,35110524,35110629,35116609,35116737,9524,"2,0",319324,"2,0",186139,170,149,1,1,"0.005,0.0","0.009,0.0",-2E-3]
[9542,"ENSG00000175166.16","PSMD2","chr3","+",184301793,184302071,184301857,184302071,184301536,184301658,9542,"55,68","17,18","84,80","9,10",213,149,0.00380826042236,0.0155430658968429,"0.694,0.725","0.867,0.848",-0.148]
[9560,"ENSG00000167792.12","NDUFV1","chr11","+",67611402,67611569,67611521,67611569,67610994,67611207,9560,26682736,"66,57",23392378,"29,41",268,149,0.0155012130456,0.0527282853926008,"0.957,0.964","0.978,0.97",-0.014]
[9582,"ENSG00000143401.14","ANP32E","chr1","-",150229071,150229237,150229071,150229144,150230570,150230693,9582,37683340,"2,0",33163006,"0,0",242,149,1,1,"0.999,1.0","1.0,1.0",0]
[9609,"ENSG00000159322.17","ADPGK","chr15","-",72751368,72752895,72751368,72752892,72755555,72755654,9609,207183,205221,116127,99104,152,149,0.0815416379671,0.215839388337427,"0.497,0.448","0.535,0.545",-0.068]
[9626,"ENSG00000177963.14","RIC8A","chr11","+",210570,210662,210574,210662,209406,210000,9626,143113,"1,2",140158,"7,4",153,149,0.0268185633401,0.0842117507614918,"0.993,0.982","0.951,0.975",0.025]
[9649,"ENSG00000164134.12","NAA15","chr4","+",139384831,139384978,139384834,139384978,139378755,139378854,9649,724614,"88,79",607572,"55,58",152,149,0.0984859624461,0.252003729270443,"0.89,0.884","0.915,0.906",-0.024]
[9670,"ENSG00000005801.17","ZNF195","chr11","-",3361742,3368855,3361742,3361889,3370974,3371070,9670,"37,14","24,29","31,23","1,2",298,149,{"v":9.59578405624e-09,"d":"9.60E-09"},{"v":1.04159472746594E-7,"d":"1.04E-07"},"0.435,0.194","0.939,0.852",-0.581]
[9693,"ENSG00000132254.12","ARFIP2","chr11","-",6479139,6479357,6479139,6479258,6479971,6480068,9693,"32,47",205187,104113,250288,248,149,{"v":5.62459495304e-05,"d":"5.62E-05"},3.44241815096389E-4,"0.086,0.131","0.2,0.191",-0.087]
[9710,"ENSG00000166436.16","TRIM66","chr11","-",8647969,8648086,8647969,8648080,8648415,8648548,9710,"30,42","0,0","19,19","0,1",155,149,1,1,"1.0,1.0","1.0,0.948",0.026]
[9713,"ENSG00000166441.12","RPL27A","chr11","+",8683960,8684081,8684005,8684081,8683201,8683265,9713,"26,40",3324330045,"41,55",3137936599,194,149,1,1,"0.001,0.001","0.001,0.001",0]
[9752,"ENSG00000169519.20","METTL15","chr11","+",28296752,28296931,28296796,28296931,28290205,28290397,9752,93110,"10,14",101125,"36,29",193,149,0.000792850916051,0.00382719013202033,"0.878,0.858","0.684,0.769",0.141]
[9774,"ENSG00000166199.12","ALKBH3","chr11","+",43886605,43886653,43886608,43886653,43883982,43884017,9774,275266,"18,12",87130,"5,0",152,149,0.0157450254118,0.0534698999754534,"0.937,0.956","0.945,1.0",-0.026]
[9779,"ENSG00000149091.15","DGKZ","chr11","+",46368001,46368079,46368004,46368079,46367290,46367399,9779,"5,9","0,1","9,1","1,0",152,149,1,1,"1.0,0.898","0.898,1.0",0]
[9820,"ENSG00000131018.22","SYNE1","chr6","-",152283977,152284184,152283977,152284172,152293587,152293749,9820,"4,5","11,8","5,6","11,20",161,149,0.653307879658,1,"0.252,0.366","0.296,0.217",0.052]
[9834,"ENSG00000198561.13","CTNND1","chr11","+",57791491,57791673,57791493,57791673,57789036,57789155,9834,"9,16","0,0","5,8","0,1",151,149,1,1,"1.0,1.0","1.0,0.888",0.056]
[9870,"ENSG00000167986.13","DDB1","chr11","-",61300808,61300936,61300808,61300932,61302256,61302359,9870,"5,4",13041592,"4,7",770782,153,149,1,1,"0.004,0.002","0.005,0.009",-0.004]
[9871,"ENSG00000162144.9","CYB561A3","chr11","-",61353783,61353992,61353783,61353823,61356529,61356728,9871,382448,"0,1",378365,"0,0",298,149,1,1,"1.0,0.996","1.0,1.0",-2E-3]
[9896,"ENSG00000167384.10","ZNF180","chr19","-",44497283,44497377,44497283,44497372,44500197,44500522,9896,"27,19","1,6","30,29","6,7",154,149,0.403228101014,0.760684859351479,"0.963,0.754","0.829,0.8",0.044]
[9907,"ENSG00000149781.12","FERMT3","chr11","+",64219739,64219789,64219744,64219789,64219523,64219658,9907,29272689,"7,19",22522439,"15,26",154,149,1,1,"0.998,0.993","0.993,0.989",0.005]
[9923,"ENSG00000068831.18","RASGRP2","chr11","-",64727295,64727363,64727295,64727360,64728862,64729042,9923,"9,23",280325,"13,14",204198,152,149,0.446221572097,0.815953237035308,"0.031,0.065","0.059,0.065",-0.014]
[9952,"ENSG00000173039.18","RELA","chr11","-",65661686,65661868,65661686,65661819,65661936,65662088,9952,"46,43","2,4","51,72","5,5",198,149,0.585055723938,0.975445741579781,"0.945,0.89","0.885,0.916",0.017]
[9959,"ENSG00000175467.14","SART1","chr11","+",65964005,65964131,65964073,65964131,65961728,65962093,9959,"10,10",405517,"11,12",369417,217,149,0.367473465247,0.706007501773878,"0.017,0.013","0.02,0.019",-0.005]
[9980,"ENSG00000172830.12","SSH3","chr11","+",67310065,67310339,67310163,67310339,67309767,67309968,9980,"6,13","0,7","20,38","5,2",247,149,0.484758561186,0.864724187549042,"1.0,0.528","0.707,0.92",-0.049]
[10008,"ENSG00000102901.12","CENPT","chr16","-",67832227,67832354,67832227,67832350,67832454,67832545,10008,"15,15","1,1","9,9","1,2",153,149,0.36511509721,0.703998954001983,"0.936,0.936","0.898,0.814",0.08]
[10017,"ENSG00000172890.12","NADSYN1","chr11","+",71476032,71477438,71477344,71477438,71474394,71474526,10017,"15,5","1,1","49,32","10,21",298,149,0.00932343664212,0.0338377505790377,"0.882,0.714","0.71,0.432",0.227]
[10038,"ENSG00000175575.12","PAAF1","chr11","+",73886928,73887099,73887039,73887099,73878778,73878819,10038,"20,15","2,0","9,8","0,0",260,149,0.67686134995,1,"0.851,1.0","1.0,1.0",-0.075]
[10053,"ENSG00000073578.16","SDHA","chr5","+",254357,254506,254392,254506,240357,240476,10053,"11,6","77,66","6,18","16,15",184,149,0.00014032245778,0.000791090511468076,"0.104,0.069","0.233,0.493",-0.276]
[10073,"ENSG00000137500.9","CCDC90B","chr11","-",83273792,83273992,83273792,83273864,83280140,83280260,10073,"7,7","0,0","17,17","0,2",277,149,0.870651627696,1,"1.0,1.0","1.0,0.821",0.09]
[10092,"ENSG00000159348.12","CYB5R1","chr1","-",202965886,202966600,202965886,202965993,202966748,202966898,10092,250311,"0,4",213272,"5,2",298,149,0.207666993126,0.458027227126042,"1.0,0.975","0.955,0.986",0.017]
[10109,"ENSG00000135452.9","TSPAN31","chr12","+",57746588,57746720,57746592,57746720,57746175,57746256,10109,"91,88","3,0","108,96","1,0",153,149,0.644161079568,1,"0.967,1.0","0.991,1.0",-0.012]
[10133,"ENSG00000196954.13","CASP4","chr11","-",104951895,104952063,104951895,104952005,104954746,104955001,10133,"27,37",631657,"8,14",436527,207,149,0.0017269631202,0.00770812979322852,"0.03,0.039","0.013,0.019",0.019]
[10158,"ENSG00000076053.10","RBM7","chr11","+",114405705,114405799,114405708,114405799,114402827,114402915,10158,299238,139124,316320,119166,152,149,0.510649531805,0.896067830566835,"0.678,0.653","0.722,0.654",-0.022]
[10186,"ENSG00000172269.18","DPAGT1","chr11","-",119100629,119100877,119100629,119100750,119101017,119101138,10186,488510,"1,11",189213,"6,3",276,149,0.280164330908,0.578969049643669,"0.996,0.962","0.944,0.975",0.019]
[10204,"ENSG00000154096.13","THY1","chr11","-",119420050,119420448,119420050,119420386,119420868,119420929,10204,"8,7",81122,"2,2",96116,211,149,3.54571261384E-3,0.0146073495810109,"0.065,0.039","0.014,0.012",0.039]
[10224,"ENSG00000166261.10","ZNF202","chr11","-",123740116,123740232,123740116,123740192,123740416,123740536,10224,85107,"13,5",99105,"0,0",189,149,{"v":8.41407031937e-07,"d":"8.41E-07"},{"v":6.99878487046493e-06,"d":"7.00E-06"},"0.838,0.944","1.0,1.0",-0.109]
[10245,"ENSG00000149547.14","EI24","chr11","+",125575262,125575408,125575304,125575408,125572457,125572569,10245,33213001,"47,27",21482305,"5,21",191,149,0.0433648732887,0.127031047044574,"0.982,0.989","0.997,0.988",-0.007]
[10263,"ENSG00000151062.14","CACNA2D4","chr12","-",1799674,1799695,1799674,1799688,1800385,1800438,10263,"4,1","0,0","16,6","0,1",156,149,1,1,"1.0,1.0","1.0,0.851",0.075]
[10282,"ENSG00000155463.12","OXA1L","chr14","+",22769790,22769934,22769796,22769934,22767957,22768171,10282,914734,"0,1",439432,"0,0",155,149,1,1,"1.0,0.999","1.0,1.0",0]
[10302,"ENSG00000089693.10","MLF2","chr12","-",6750176,6750766,6750176,6750305,6751640,6751676,10302,11911208,"0,2",11791210,"0,0",298,149,1,1,"1.0,0.997","1.0,1.0",-2E-3]
[10316,"ENSG00000164253.13","WDR41","chr5","-",77489456,77489572,77489456,77489557,77491192,77491285,10316,"23,17","0,1","19,18","2,0",164,149,1,1,"1.0,0.939","0.896,1.0",0.022]
[10335,"ENSG00000104756.15","KCTD9","chr8","-",25439605,25439792,25439605,25439664,25440576,25440673,10335,"26,32",232244,256217,"73,67",277,149,0,0,"0.057,0.066","0.654,0.635",-0.583]
[10345,"ENSG00000093010.13","COMT","chr22","+",19962232,19962815,19962526,19962815,19961198,19961289,10345,"8,18",653689,"43,35",327269,298,149,{"v":4.4408920985E-16,"d":"4.44E-16"},{"v":1.01455421963803E-14,"d":"1.01E-14"},"0.006,0.013","0.062,0.061",-0.052]
[10387,"ENSG00000111348.8","ARHGDIB","chr12","-",14947872,14947949,14947872,14947946,14949801,14949885,10387,94538744,"44,28",86459064,"48,40",152,149,1,1,"0.995,0.997","0.994,0.996",1E-3]
[10407,"ENSG00000185499.16","MUC1","chr1","-",155188162,155188231,155188162,155188212,155188327,155188503,10407,"2,0","0,0","1,4","5,3",168,149,1,1,"1.0,NA","0.151,0.542",0.653]
[10418,"ENSG00000157870.15","PRXL2B","chr1","+",2588953,2589040,2588956,2589040,2588389,2588453,10418,"0,4","1,2","3,6","0,0",152,149,0.0207975553474,0.0678230933920519,"0.0,0.662","1.0,1.0",-0.669]
[10446,"ENSG00000139218.17","SCAF11","chr12","-",45919130,45922194,45919130,45919309,45922462,45922582,10446,957886,"78,84",236228,379469,298,149,0,0,"0.86,0.841","0.237,0.196",0.634]
[10466,"ENSG00000174233.11","ADCY6","chr12","-",48777103,48777521,48777103,48777231,48777614,48777736,10466,103108,"0,0",183178,"1,2",298,149,0.662495766521,1,"1.0,1.0","0.989,0.978",0.016]
[10477,"ENSG00000181929.12","PRKAG1","chr12","-",49005742,49005881,49005742,49005852,49013061,49013110,10477,"0,3",370306,"6,18",130179,178,149,{"v":3.98734077978e-08,"d":"3.99E-08"},{"v":4.07731406741252e-07,"d":"4.08E-07"},"0.0,0.008","0.037,0.078",-0.053]
[10507,"ENSG00000050426.15","LETMD1","chr12","+",51055834,51056021,51055986,51056021,51049033,51049185,10507,282274,"7,7","89,76","1,0",298,149,0.00951152960821,0.0344751376926947,"0.953,0.951","0.978,1.0",-0.037]
[10529,"ENSG00000094914.12","AAAS","chr12","-",53315334,53315486,53315334,53315426,53315726,53315782,10529,"14,4",787747,"17,15",802836,209,149,0.298857701955,0.607642368966715,"0.013,0.004","0.015,0.013",-0.005]
[10541,"ENSG00000173581.7","CCDC106","chr19","+",55648757,55649077,55648945,55649077,55648232,55648277,10541,118145,"11,8","45,49","16,27",298,149,{"v":5.01532637642e-09,"d":"5.02E-09"},{"v":5.56788509232276e-08,"d":"5.57E-08"},"0.843,0.901","0.584,0.476",0.342]
[10572,"ENSG00000092841.18","MYL6","chr12","+",56159974,56160148,56160024,56160148,56158683,56158711,10572,25572268,"0,2",17971978,"0,0",199,149,1,1,"1.0,0.999","1.0,1.0",0]
[10589,"ENSG00000196531.10","NACA","chr12","-",56714601,56714687,56714601,56714675,56724451,56724523,10589,1472014234,373364,1414315572,363391,161,149,1,1,"0.973,0.973","0.973,0.974",-1E-3]
[10605,"ENSG00000166987.14","MBD6","chr12","+",57524629,57524822,57524719,57524822,57524279,57524416,10605,"2,4",193202,"6,7",322366,239,149,0.793137032635,1,"0.006,0.012","0.011,0.012",-2E-3]
[10639,"ENSG00000156482.10","RPL30","chr8","-",98042644,98042775,98042644,98042718,98044942,98045088,10639,2369424740,486543,2509730189,386459,206,149,0.00334681385888,0.0139053744146752,"0.972,0.971","0.979,0.979",-0.007]
[10640,"ENSG00000156482.10","RPL30","chr8","-",98042644,98042775,98042644,98042718,98045346,98045399,10640,33643632,"2,0",36854619,"0,3",206,149,1,1,"0.999,1.0","1.0,0.999",0]
[10691,"ENSG00000075856.11","SART3","chr12","-",108544426,108544532,108544426,108544478,108545138,108545323,10691,84126,634663,"31,36",403380,203,149,0.000224263941027,1.21160968269505E-3,"0.089,0.122","0.053,0.065",0.046]
[10692,"ENSG00000205659.10","LIN52","chr14","+",74091231,74091306,74091237,74091306,74084962,74084993,10692,"74,73","1,0","59,60","2,2",155,149,0.734835638946,1,"0.986,1.0","0.966,0.966",0.027]
[10709,"ENSG00000268107.5","AC003005.1","chr19","+",57504656,57504786,57504659,57504786,57491470,57491597,10709,"8,0","0,0","0,3","5,0",152,149,1,1,"1.0,NA","0.0,1.0",0.5]
[10733,"ENSG00000089157.15","RPLP0","chr12","-",120198553,120198770,120198553,120198739,120198853,120199000,10733,138129,4057938704,133158,3707240613,180,149,1,1,"0.003,0.003","0.003,0.003",0]
[10752,"ENSG00000033030.13","ZCCHC8","chr12","-",122483278,122483563,122483278,122483344,122489385,122489463,10752,308284,"1,0",151178,"3,0",298,149,0.586383575236,0.976874043678615,"0.994,1.0","0.962,1.0",0.016]
[10774,"ENSG00000151092.16","NGLY1","chr3","-",25736308,25737455,25736308,25736400,25739576,25739799,10774,451451,"0,0","41,42","1,0",298,149,1,1,"1.0,1.0","0.953,1.0",0.024]
[10795,"ENSG00000116871.15","MAP7D1","chr1","+",36178445,36178596,36178470,36178596,36177872,36178201,10795,152185,"19,9",165215,"14,7",174,149,0.187009554934,0.421317641691839,"0.873,0.946","0.91,0.963",-0.027]
[10816,"ENSG00000197555.9","SIPA1L1","chr14","+",71650289,71650509,71650334,71650509,71624047,71624236,10816,"1,0","71,77","0,0","92,93",194,149,1,1,"0.011,0.0","0.0,0.0",0.005]
[10839,"ENSG00000136104.20","RNASEH2B","chr13","+",50947986,50949505,50949462,50949505,50945426,50945532,10839,17161594,"0,0",932932,"5,4",298,149,1,1,"1.0,1.0","0.989,0.991",0.01]
[10869,"ENSG00000006704.10","GTF2IRD1","chr7","+",74515344,74515596,74515440,74515596,74512829,74512971,10869,"1,0","46,37","9,0","20,28",245,149,0.000716212722283,0.00350003070471002,"0.013,0.0","0.215,0.0",-0.101]
[10882,"ENSG00000119684.15","MLH3","chr14","-",75030542,75030715,75030542,75030702,75038339,75038412,10882,"1,3","0,0","5,4","12,2",162,149,{"v":1.45118623329e-06,"d":"1.45E-06"},{"v":1.16841625559941E-5,"d":"1.17E-05"},"1.0,1.0","0.277,0.648",0.537]
[10902,"ENSG00000068650.18","ATP11A","chr13","+",112857817,112859452,112859392,112859452,112854278,112854530,10902,"15,14","0,0","49,52","0,2",298,149,0.387384808549,0.735649694824102,"1.0,1.0","1.0,0.929",0.035]
[10927,"ENSG00000092201.9","SUPT16H","chr14","-",21371873,21372044,21371873,21371970,21372468,21372717,10927,910664,"0,0",340324,"0,3",223,149,1,1,"1.0,1.0","1.0,0.986",0.007]
[10940,"ENSG00000196182.10","STK40","chr1","-",36358736,36358837,36358736,36358822,36361220,36361340,10940,"21,22",322303,"14,19",308336,164,149,0.241732787711,0.516170471588141,"0.056,0.062","0.04,0.049",0.014]
[10957,"ENSG00000235194.8","PPP1R3E","chr14","-",23299400,23299541,23299400,23299538,23300106,23300940,10957,"8,6","1,1","6,14","0,0",152,149,0.277234110134,0.574488374647991,"0.887,0.855","1.0,1.0",-0.129]
[10988,"ENSG00000168701.18","TMEM208","chr16","+",67228494,67228881,67228796,67228881,67228354,67228414,10988,384415,"0,0",425462,"2,0",298,149,1,1,"1.0,1.0","0.991,1.0",0.004]
[11000,"ENSG00000214078.12","CPNE1","chr20","-",35658929,35659014,35658929,35658982,35664878,35664932,11000,227193,"6,5","50,68","2,0",181,149,0.132653162827,0.319794383524509,"0.969,0.969","0.954,1.0",-0.008]
[11019,"ENSG00000172828.12","CES3","chr16","+",66972667,66972746,66972676,66972746,66972355,66972505,11019,"99,92","1,0","84,91","2,0",158,149,1,1,"0.989,1.0","0.975,1.0",0.007]
[11030,"ENSG00000167460.15","TPM4","chr19","+",16080914,16081075,16081019,16081075,16077956,16078149,11030,"97,78","2,3","54,83","0,0",254,149,0.106774250157,0.268793397991058,"0.966,0.938","1.0,1.0",-0.048]
[11064,"ENSG00000139974.15","SLC38A6","chr14","+",61078809,61078927,61078829,61078927,61052040,61052135,11064,"5,25","15,6","7,5","2,0",169,149,0.00994767974192,0.035788052375969,"0.227,0.786","0.755,1.0",-0.371]
[11081,"ENSG00000139990.17","DCAF5","chr14","-",69118138,69118275,69118138,69118194,69119193,69119230,11081,108104,"0,0","108,92","2,0",230,149,1,1,"1.0,1.0","0.972,1.0",0.014]
[11092,"ENSG00000119711.12","ALDH6A1","chr14","-",74071194,74071660,74071194,74071497,74071895,74071974,11092,"4,1","44,24","5,2","15,13",298,149,0.0652505227259,0.179001847491197,"0.043,0.02","0.143,0.071",-0.075]
[11115,"ENSG00000100722.19","ZC3H14","chr14","+",88609711,88609803,88609714,88609803,88609266,88609403,11115,190199,113110,105131,"54,77",152,149,0.825595600515,1,"0.622,0.639","0.656,0.625",-0.01]
[11132,"ENSG00000165949.12","IFI27","chr14","+",94115780,94115942,94115789,94115942,94114850,94114880,11132,"3,2","0,1","6,1","0,0",158,149,1,1,"1.0,0.654","1.0,1.0",-0.173]
[11147,"ENSG00000112759.17","SLC29A1","chr6","+",44227259,44227342,44227262,44227342,44226060,44226167,11147,95132,146115,"58,81","43,82",152,149,0.265185106173,0.554583282014712,"0.389,0.529","0.569,0.492",-0.071]
[11169,"ENSG00000131591.17","C1orf159","chr1","-",1083914,1084086,1083914,1084011,1084352,1084383,11169,"40,60","0,1","64,85","1,4",224,149,0.0805221564115,0.213823324726407,"1.0,0.976","0.977,0.934",0.032]
[11186,"ENSG00000067182.7","TNFRSF1A","chr12","-",6333736,6333865,6333736,6333838,6334090,6334244,11186,757759,"0,9",9241086,"0,2",176,149,1,1,"1.0,0.986","1.0,0.998",-0.006]
[11210,"ENSG00000275835.4","TUBGCP5","chr15","-",23027191,23027309,23027191,23027306,23030884,23031020,11210,"47,64",223229,"34,64",199187,152,149,0.936995955986,1,"0.171,0.215","0.143,0.251",-0.004]
[11235,"ENSG00000172575.11","RASGRP1","chr15","-",38498793,38499184,38498793,38498946,38500102,38500139,11235,"0,0","3,0","2,0","0,0",298,149,1,1,"0.0,NA","1.0,NA",-1]
[11255,"ENSG00000168781.22","PPIP5K1","chr15","-",43573033,43573160,43573033,43573148,43573356,43573484,11255,"6,2","0,4","10,8","0,0",161,149,0.013856061077,0.047878464379817,"1.0,0.316","1.0,1.0",-0.342]
[11259,"ENSG00000168781.22","PPIP5K1","chr15","-",43584357,43584621,43584357,43584589,43584798,43584892,11259,"2,4","4,0","0,5","1,1",181,149,0.608574652173,1,"0.292,1.0","0.0,0.805",0.243]
[11260,"ENSG00000168781.22","PPIP5K1","chr15","-",43584357,43584621,43584357,43584532,43590171,43590201,11260,"6,2","0,2","3,3","6,0",238,149,0.276257595058,0.572751058953998,"1.0,0.385","0.238,1.0",0.074]
[11261,"ENSG00000205771.6","CATSPER2P1","chr15","-",43745021,43745170,43745021,43745167,43746047,43746302,11261,"1,0","0,1","2,4","2,1",152,149,0.122826988533,0.299734249160274,"1.0,0.0","0.495,0.797",-0.146]
[11263,"ENSG00000205771.6","CATSPER2P1","chr15","-",43745021,43745170,43745021,43745167,43746530,43747094,11263,"0,0","1,1","1,0","1,14",152,149,1,1,"0.0,0.0","0.495,0.0",-0.247]
[11265,"ENSG00000185880.12","TRIM69","chr15","+",44758612,44758854,44758620,44758854,44756367,44756463,11265,"0,0","2,0","1,0","0,0",157,149,1,1,"0.0,NA","1.0,NA",-1]
[11268,"ENSG00000239900.12","ADSL","chr22","+",40361087,40361342,40361272,40361342,40360401,40360492,11268,"22,24",21942085,110132,581564,298,149,0,0,"0.005,0.006","0.086,0.105",-0.09]
[11270,"ENSG00000104164.10","BLOC1S6","chr15","+",45603099,45603187,45603103,45603187,45592134,45592276,11270,333292,"37,35","79,68","12,14",153,149,0.166056883304,0.383062512723246,"0.898,0.89","0.865,0.825",0.049]
[11271,"ENSG00000104164.10","BLOC1S6","chr15","+",45603099,45603187,45603103,45603187,45601233,45601407,11271,"8,6","0,0","32,15","4,1",153,149,0.0147488385103,0.0505840023845814,"1.0,1.0","0.886,0.936",0.089]
[11272,"ENSG00000128951.13","DUT","chr15","+",48341462,48341585,48341514,48341585,48341288,48341363,11272,"34,20",49104758,"20,20",35714049,201,149,1,1,"0.005,0.003","0.004,0.004",0]
[11274,"ENSG00000115282.19","TTC31","chr2","+",74490024,74490473,74490243,74490473,74483321,74483410,11274,427355,"4,5","18,28",130172,298,149,0,0,"0.982,0.973","0.065,0.075",0.907]
[11275,"ENSG00000115282.19","TTC31","chr2","+",74490024,74490473,74490243,74490473,74483321,74483563,11275,"60,74","1,6","1,6","31,22",298,149,0,0,"0.968,0.86","0.016,0.12",0.846]
[11276,"ENSG00000115282.19","TTC31","chr2","+",74490655,74491184,74491127,74491184,74490243,74490473,11276,154144,"0,0",135167,"4,0",298,149,0.63912877707,1,"1.0,1.0","0.944,1.0",0.028]
[11277,"ENSG00000115282.19","TTC31","chr2","+",74491943,74492055,74492003,74492055,74491480,74491666,11277,"20,17",144176,"23,38","79,84",209,149,{"v":2.58457094615e-06,"d":"2.58E-06"},{"v":1.98461544966869E-5,"d":"1.98E-05"},"0.09,0.064","0.172,0.244",-0.131]
[11278,"ENSG00000115282.19","TTC31","chr2","+",74491943,74492055,74492003,74492055,74491583,74491672,11278,"22,13",143108,"32,18",128168,209,149,0.420469098452,0.785703071983424,"0.099,0.079","0.151,0.071",-0.022]
[11279,"ENSG00000115282.19","TTC31","chr2","+",74492645,74492747,74492675,74492747,74492303,74492445,11279,224195,"21,11",82101,"3,6",179,149,0.148558935484,0.351197050162147,"0.899,0.937","0.958,0.933",-0.027]
[11280,"ENSG00000115282.19","TTC31","chr2","+",74492921,74494559,74492924,74494559,74492645,74492747,11280,145117,"8,7","33,49","3,1",152,149,0.412259443543,0.77332448887177,"0.947,0.942","0.915,0.98",-0.003]
[11281,"ENSG00000104047.14","DTWD1","chr15","+",49630955,49631058,49631000,49631058,49625112,49625431,11281,"12,10","28,16","17,22","9,10",194,149,1.72539936945E-4,0.00095391579805659,"0.248,0.324","0.592,0.628",-0.324]
[11282,"ENSG00000104047.14","DTWD1","chr15","+",49632158,49632302,49632170,49632302,49625112,49625431,11282,304237,"13,6",245233,"11,7",161,149,0.856133303379,1,"0.956,0.973","0.954,0.969",0.003]
[11283,"ENSG00000092439.14","TRPM7","chr15","-",50575723,50575919,50575723,50575789,50578638,50578664,11283,254319,"0,0",191209,"4,1",279,149,0.869638523657,1,"1.0,1.0","0.962,0.991",0.024]
[11284,"ENSG00000092439.14","TRPM7","chr15","-",50583088,50583159,50583088,50583156,50586391,50586488,11284,249256,147179,87104,"45,59",152,149,0.311630366599,0.626806616349576,"0.624,0.584","0.655,0.633",-0.04]
[11285,"ENSG00000092439.14","TRPM7","chr15","-",50583088,50583159,50583088,50583156,50589591,50589656,11285,"3,4","0,2","25,20","24,26",152,149,0.00968533144657,0.0350132753646054,"1.0,0.662","0.505,0.43",0.363]
[11286,"ENSG00000081014.10","AP4E1","chr15","+",50915424,50915571,50915447,50915571,50912077,50912149,11286,"4,4","35,37","12,20","24,29",172,149,{"v":1.48307348194E-5,"d":"1.48E-05"},1.00895228759051E-4,"0.09,0.086","0.302,0.374",-0.25]
[11287,"ENSG00000081014.10","AP4E1","chr15","+",50934535,50934697,50934623,50934697,50930804,50930971,11287,"1,3","48,45","0,1","28,33",237,149,0.726928228026,1,"0.013,0.04","0.0,0.019",0.017]
[11288,"ENSG00000081014.10","AP4E1","chr15","+",50941665,50941775,50941697,50941775,50941441,50941564,11288,"57,80","0,1","42,49","0,0",181,149,1,1,"1.0,0.985","1.0,1.0",-0.008]
[11289,"ENSG00000081014.10","AP4E1","chr15","+",50949823,50949938,50949825,50949938,50948019,50948159,11289,"0,0","41,36","2,0","30,19",151,149,0.298875343424,0.607642368966715,"0.0,0.0","0.062,0.0",-0.031]
[11290,"ENSG00000110200.8","ANAPC15","chr11","-",72109586,72109940,72109586,72109928,72110087,72110225,11290,"32,55",16591481,"56,46",15811841,161,149,0.679663230683,1,"0.018,0.033","0.032,0.023",-2E-3]
[11291,"ENSG00000110200.8","ANAPC15","chr11","-",72111156,72111286,72111156,72111281,72111411,72111496,11291,536491,203198,564588,247258,154,149,0.36625522059,0.705130347201886,"0.719,0.706","0.688,0.688",0.024]
[11292,"ENSG00000110200.8","ANAPC15","chr11","-",72111156,72111286,72111156,72111281,72111441,72111496,11292,156137,"5,9",98142,"5,2",154,149,0.214321036567,0.470202210648182,"0.968,0.936","0.95,0.986",-0.016]
[11293,"ENSG00000069869.16","NEDD4","chr15","-",55862912,55863079,55862912,55863031,55869578,55869681,11293,210208,"0,0",204192,"5,1",197,149,0.807109208289,1,"1.0,1.0","0.969,0.993",0.019]
[11294,"ENSG00000069869.16","NEDD4","chr15","-",55951375,55951439,55951375,55951414,55951510,55951589,11294,"0,0",216159,"0,2",224189,174,149,1,1,"0.0,0.0","0.0,0.009",-0.004]
[11295,"ENSG00000137871.20","ZNF280D","chr15","-",56707081,56707150,56707081,56707143,56707262,56707306,11295,"104,69","19,31","5,6","0,3",156,149,0.322100756723,0.643213683620164,"0.839,0.68","1.0,0.656",-0.069]
[11296,"ENSG00000137878.17","GCOM1","chr15","+",57708713,57709358,57709184,57709358,57706491,57706955,11296,647578,"3,2",965908,"1,1",298,149,1,1,"0.991,0.993","0.998,0.998",-0.006]
[11297,"ENSG00000133103.16","COG6","chr13","+",39659363,39659507,39659413,39659507,39655661,39655879,11297,121134,"0,0","84,83","0,1",199,149,1,1,"1.0,1.0","1.0,0.984",0.008]
[11298,"ENSG00000186654.20","PRR5","chr22","+",44731678,44731821,44731729,44731821,44726576,44726634,11298,"6,2","88,80","36,16","55,76",200,149,{"v":1.05697760655E-7,"d":"1.06E-07"},{"v":1.00637374180472E-6,"d":"1.01E-06"},"0.048,0.018","0.328,0.136",-0.199]
[11299,"ENSG00000186654.20","PRR5","chr22","+",44731678,44731821,44731734,44731821,44726576,44726634,11299,"13,11","18,27","40,22","17,29",205,149,0.0385695343424,0.115222315670577,"0.344,0.228","0.631,0.355",-0.207]
[11300,"ENSG00000186654.20","PRR5","chr22","+",44731729,44731821,44731734,44731821,44726576,44726634,11300,"95,89","18,27","59,82","17,29",154,149,0.272940676189,0.56672434342398,"0.836,0.761","0.771,0.732",0.047]
[11301,"ENSG00000157450.15","RNF111","chr15","+",59084101,59084254,59084128,59084254,59080935,59081284,11301,"19,19","70,70","102,90","16,32",176,149,0,0,"0.187,0.187","0.844,0.704",-0.587]
[11302,"ENSG00000157450.15","RNF111","chr15","+",59092512,59092640,59092536,59092640,59091058,59091154,11302,"54,40","86,83","96,69",135142,173,149,0.723596604077,1,"0.351,0.293","0.38,0.295",-0.016]
[11303,"ENSG00000137776.16","SLTM","chr15","-",58899468,58899937,58899468,58899883,58901259,58901287,11303,433430,191139,551475,"39,59",203,149,0,0,"0.625,0.694","0.912,0.855",-0.224]
[11304,"ENSG00000137776.16","SLTM","chr15","-",58916934,58917020,58916934,58916999,58921445,58921584,11304,"1,1","0,6","2,6","0,0",170,149,0.00383717917153,0.0156295318612467,"1.0,0.127","1.0,1.0",-0.436]
[11305,"ENSG00000137776.16","SLTM","chr15","-",58916934,58917020,58916934,58916999,58932355,58932443,11305,"6,5",493496,"3,7",420365,170,149,0.92754481546,1,"0.011,0.009","0.006,0.017",-2E-3]
[11306,"ENSG00000140307.10","GTF2A2","chr15","-",59650668,59650773,59650668,59650764,59652205,59652326,11306,13861216,"41,37",10791076,"13,23",158,149,0.00671081023584,0.0254897143319894,"0.97,0.969","0.987,0.978",-0.013]
[11307,"ENSG00000102543.14","CDADC1","chr13","+",49259345,49259523,49259485,49259523,49255838,49255913,11307,249194,"16,15",203298,"49,54",289,149,{"v":1.04337647899e-06,"d":"1.04E-06"},{"v":8.5534594545503e-06,"d":"8.55E-06"},"0.889,0.87","0.681,0.74",0.169]
[11308,"ENSG00000128915.11","ICE2","chr15","-",60468060,60468322,60468060,60468162,60476062,60476167,11308,318296,"71,94",336321,"72,71",298,149,0.22006085947,0.480001238186404,"0.691,0.612","0.7,0.693",-0.045]
[11309,"ENSG00000177830.17","CHID1","chr11","-",870418,870499,870418,870489,883147,883303,11309,227248,"3,0",189215,"2,0",159,149,1,1,"0.986,1.0","0.989,1.0",-1E-3]
[11310,"ENSG00000129003.17","VPS13C","chr15","-",61876972,61877086,61876972,61877054,61878606,61878746,11310,"0,1",186183,"1,0",92110,181,149,1,1,"0.0,0.004","0.009,0.0",-2E-3]
[11312,"ENSG00000028203.17","VEZT","chr12","+",95257149,95257239,95257153,95257239,95251939,95252071,11312,"118,92","13,1",163151,"8,2",153,149,0.0928815931528,0.239510899258759,"0.898,0.989","0.952,0.987",-0.026]
[11313,"ENSG00000028203.17","VEZT","chr12","+",95257149,95257239,95257153,95257239,95256549,95256622,11313,"94,83","3,0","98,96","2,2",153,149,0.696207473674,1,"0.968,1.0","0.979,0.979",0.005]
[11314,"ENSG00000028203.17","VEZT","chr12","+",95270038,95270188,95270050,95270188,95266356,95266632,11314,182135,210183,296374,114132,161,149,0,0,"0.445,0.406","0.706,0.724",-0.289]
[11315,"ENSG00000028203.17","VEZT","chr12","+",95274741,95274889,95274745,95274889,95270038,95270188,11315,289229,"8,1",317289,"9,6",153,149,0.339481971525,0.6677713448427,"0.972,0.996","0.972,0.979",0.008]
[11316,"ENSG00000028203.17","VEZT","chr12","+",95299093,95301172,95300164,95301172,95296050,95296258,11316,"19,16",223204,"5,5",283273,298,149,{"v":9.11937170933e-06,"d":"9.12E-06"},{"v":6.45832191165445e-05,"d":"6.46E-05"},"0.041,0.038","0.009,0.009",0.03]
[11319,"ENSG00000166938.12","DIS3L","chr15","+",66306761,66306952,66306823,66306952,66294987,66295141,11319,"9,4",179147,"2,0","42,63",211,149,0.0806361285068,0.21405743076405,"0.034,0.019","0.033,0.0",0.01]
[11320,"ENSG00000166938.12","DIS3L","chr15","+",66306761,66306952,66306896,66306952,66294987,66295141,11320,"80,82","5,3","17,30","11,4",284,149,0.00146984482897,0.00665724913525298,"0.894,0.935","0.448,0.797",0.292]
[11321,"ENSG00000166938.12","DIS3L","chr15","+",66306823,66306952,66306896,66306952,66294987,66295141,11321,250225,"5,3","57,93","11,4",222,149,1.58476703341E-4,0.000883230712907871,"0.971,0.981","0.777,0.94",0.117]
[11322,"ENSG00000166938.12","DIS3L","chr15","+",66320570,66320732,66320649,66320732,66318448,66318618,11322,215163,"1,0","89,76","0,0",228,149,1,1,"0.993,1.0","1.0,1.0",-0.004]
[11323,"ENSG00000174444.14","RPL4","chr15","-",66500948,66501504,66500948,66501105,66501787,66501912,11323,2736927234,"0,0",3015829689,"1,0",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[11324,"ENSG00000174444.14","RPL4","chr15","-",66502611,66502871,66502611,66502750,66503357,66503529,11324,341297,"2,2",200182,"3,0",270,149,1,1,"0.989,0.988","0.974,1.0",1E-3]
[11325,"ENSG00000174444.14","RPL4","chr15","-",66502611,66503164,66502611,66502750,66503357,66503529,11325,2190121154,"2,2",2413626654,"3,0",298,149,1,1,"1.0,1.0","1.0,1.0",0]
[11326,"ENSG00000174444.14","RPL4","chr15","-",66502611,66503164,66502611,66502871,66503357,66503529,11326,2172820992,"9,3",2402526554,"14,12",298,149,1,1,"0.999,1.0","0.999,0.999",1E-3]
[11327,"ENSG00000174151.14","CYB561D1","chr1","+",109495678,109498855,109495755,109498855,109495142,109495180,11327,"17,5","35,43","12,15","47,23",226,149,0.361638349473,0.699377653289932,"0.243,0.071","0.144,0.301",-0.065]
[11328,"ENSG00000128973.12","CLN6","chr15","-",68209636,68209759,68209636,68209720,68211262,68213332,11328,14421519,"2,1",828655,"3,2",188,149,1,1,"0.998,0.999","0.995,0.996",0.003]
[11329,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211741,68211555,68211643,68214289,68214388,11329,"48,72","0,2","78,82","2,0",247,149,0.65226737929,1,"1.0,0.956","0.959,1.0",-2E-3]
[11330,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211863,68211555,68211643,68214289,68214388,11330,848880,"0,2",435413,"2,0",298,149,1,1,"1.0,0.995","0.991,1.0",2E-3]
[11331,"ENSG00000128973.12","CLN6","chr15","-",68211555,68211863,68211555,68211741,68214289,68214388,11331,15641472,"12,5",672751,"4,17",271,149,0.00762601384562,0.0284748009102776,"0.986,0.994","0.989,0.96",0.016]
[11332,"ENSG00000128973.12","CLN6","chr15","-",68211674,68211921,68211674,68211863,68214289,68214388,11332,"22,29",788801,"44,28",338317,207,149,{"v":8.37938851639e-09,"d":"8.38E-09"},{"v":9.14345644295029e-08,"d":"9.14E-08"},"0.02,0.025","0.086,0.06",-0.05]
[11333,"ENSG00000198612.10","COPS8","chr2","+",237093662,237094197,237094089,237094197,237088604,237088653,11333,"15,10","1,11","32,36","33,35",298,149,0.154137182308,0.361805732488039,"0.882,0.312","0.327,0.34",0.263]
[11334,"ENSG00000198612.10","COPS8","chr2","+",237093662,237094197,237094089,237094197,237089861,237089994,11334,"14,10",615654,"32,36",351353,298,149,{"v":3.39774874902e-11,"d":"3.40E-11"},{"v":4.87500525529807e-10,"d":"4.88E-10"},"0.011,0.008","0.044,0.049",-0.037]
[11335,"ENSG00000245750.8","DRAIC","chr15","+",69565193,69565527,69565223,69565527,69563589,69563804,11335,"2,0","0,0","0,0","0,2",179,149,1,1,"1.0,NA","NA,0.0",1]
[11337,"ENSG00000145020.15","AMT","chr3","-",49416821,49417367,49416821,49417309,49417614,49417718,11337,"5,7","0,1","14,9","0,0",207,149,1,1,"1.0,0.834","1.0,1.0",-0.083]
[11338,"ENSG00000145020.15","AMT","chr3","-",49418970,49419405,49418970,49419151,49419709,49419788,11338,"48,35","1,4","18,36","0,0",298,149,0.0104349781476,0.0372844781465087,"0.96,0.814","1.0,1.0",-0.113]
[11339,"ENSG00000145020.15","AMT","chr3","-",49419259,49419393,49419259,49419335,49419709,49419788,11339,"8,13","0,2","11,9","0,0",207,149,0.748255573753,1,"1.0,0.824","1.0,1.0",-0.088]
[11340,"ENSG00000145020.15","AMT","chr3","-",49419259,49419405,49419259,49419335,49419709,49419788,11340,"54,42","0,2","25,40","0,0",219,149,0.41593489132,0.778985558653288,"1.0,0.935","1.0,1.0",-0.032]
[11343,"ENSG00000145020.15","AMT","chr3","-",49418970,49421572,49418970,49419151,49422103,49422271,11343,"15,21","0,1","12,16","0,0",298,149,1,1,"1.0,0.913","1.0,1.0",-0.043]
[11345,"ENSG00000171307.18","ZDHHC16","chr10","+",97452806,97452923,97452894,97452923,97452414,97452503,11345,"18,36",442269,"16,7","52,55",237,149,0.00226362694616,0.00980786743182073,"0.025,0.078","0.162,0.074",-0.066]
[11346,"ENSG00000171307.18","ZDHHC16","chr10","+",97455638,97455783,97455659,97455783,97454713,97454799,11346,"21,6",443389,"5,3","25,23",170,149,0.00893331799391,0.0326505095299672,"0.04,0.013","0.149,0.103",-0.1]
[11347,"ENSG00000171307.18","ZDHHC16","chr10","+",97455638,97455783,97455713,97455783,97454713,97454799,11347,121101,"33,29","15,26","19,15",224,149,0.00166648224774,0.00744619465544602,"0.709,0.698","0.344,0.536",0.264]
[11348,"ENSG00000171307.18","ZDHHC16","chr10","+",97455659,97455783,97455713,97455783,97454713,97454799,11348,543484,"33,29","35,46","19,15",203,149,{"v":1.23099752614e-10,"d":"1.23E-10"},{"v":1.65994511939496E-9,"d":"1.66E-09"},"0.924,0.925","0.575,0.692",0.291]
[11349,"ENSG00000125676.19","THOC2","chrX","-",123610917,123610963,123610917,123610957,123611439,123611516,11349,731640,119126,371433,114119,155,149,0.000726313995714,0.0035473038671709,"0.855,0.83","0.758,0.778",0.075]
[11350,"ENSG00000125676.19","THOC2","chrX","-",123619400,123619517,123619400,123619436,123620906,123620965,11350,213177,742659,"53,25",378420,230,149,{"v":3.41695560735e-11,"d":"3.42E-11"},{"v":4.89409548389525e-10,"d":"4.89E-10"},"0.157,0.148","0.083,0.037",0.092]
[11352,"ENSG00000125676.19","THOC2","chrX","-",123696720,123696842,123696720,123696835,123703453,123703505,11352,"9,6","0,0","4,7","0,1",156,149,1,1,"1.0,1.0","1.0,0.87",0.065]
[11354,"ENSG00000140463.13","BBS4","chr15","+",72722788,72722847,72722793,72722847,72716777,72716850,11354,"4,3",159124,"14,12","58,55",154,149,{"v":1.460909127E-8,"d":"1.46E-08"},{"v":1.56731169342962e-07,"d":"1.57E-07"},"0.024,0.023","0.189,0.174",-0.158]
[11355,"ENSG00000067141.16","NEO1","chr15","+",73236286,73236506,73236346,73236506,73178306,73178427,11355,"90,95","53,44",256194,"17,11",209,149,0,0,"0.548,0.606","0.915,0.926",-0.344]
[11356,"ENSG00000067141.16","NEO1","chr15","+",73270009,73270233,73270057,73270233,73266315,73266411,11356,"1,0",174119,"42,33","110,90",197,149,0,0,"0.004,0.0","0.224,0.217",-0.218]
[11357,"ENSG00000156642.16","NPTN","chr15","-",73563235,73563257,73563235,73563245,73570149,73570423,11357,738670,"1,3",552496,"0,3",161,149,1,1,"0.999,0.995","1.0,0.994",0]
[11358,"ENSG00000103653.16","CSK","chr15","+",74800411,74800746,74800680,74800746,74799271,74799491,11358,19412123,"0,0",13311377,"3,0",298,149,1,1,"1.0,1.0","0.996,1.0",2E-3]
[11359,"ENSG00000103653.16","CSK","chr15","+",74801694,74802083,74801996,74802083,74801011,74801102,11359,"26,52","2,0","46,37","0,0",298,149,0.857843098693,1,"0.867,1.0","1.0,1.0",-0.067]
[11360,"ENSG00000140474.13","ULK3","chr15","-",74838151,74838192,74838151,74838173,74838265,74838344,11360,367413,"3,3",201156,"1,0",168,149,1,1,"0.991,0.992","0.994,1.0",-0.005]
[11361,"ENSG00000140474.13","ULK3","chr15","-",74841404,74841509,74841404,74841505,74842074,74842195,11361,766813,"8,10",519524,"9,17",153,149,0.0156858625552,0.0533126467910957,"0.989,0.988","0.983,0.968",0.013]
[11362,"ENSG00000140474.13","ULK3","chr15","-",74842074,74842195,74842074,74842118,74842279,74842420,11362,988964,"32,24",557637,"31,26",226,149,0.0199012093173,0.0652850984447661,"0.953,0.964","0.922,0.942",0.026]
[11363,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842420,74842279,74842417,74842534,74842676,11363,"57,54","1,1","44,62","3,1",152,149,0.273852178296,0.568474621929594,"0.982,0.981","0.935,0.984",0.022]
[11364,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842449,74842279,74842417,74842534,74842676,11364,"8,17","1,1","23,24","3,1",181,149,0.802545715353,1,"0.868,0.933","0.863,0.952",-0.007]
[11365,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842449,74842279,74842420,74842534,74842676,11365,"2,9","51,46","22,23","43,61",178,149,0.000101958692394,0.000590463293312459,"0.032,0.141","0.3,0.24",-0.184]
[11366,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842420,74842279,74842417,74842538,74842676,11366,"27,35","1,0","23,8","0,0",152,149,1,1,"0.964,1.0","1.0,1.0",-0.018]
[11367,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842449,74842279,74842417,74842538,74842676,11367,"8,17","1,0","25,20","0,0",181,149,1,1,"0.868,1.0","1.0,1.0",-0.066]
[11368,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842449,74842279,74842420,74842538,74842676,11368,"2,9","21,27","24,19","22,7",178,149,{"v":2.55816457865e-05,"d":"2.56E-05"},1.68371895640828E-4,"0.074,0.218","0.477,0.694",-0.439]
[11369,"ENSG00000140474.13","ULK3","chr15","-",74842279,74842449,74842279,74842420,74843003,74843346,11369,"2,9",659628,"26,20",263279,178,149,{"v":3.87911924804e-13,"d":"3.88E-13"},{"v":6.96310301385188e-12,"d":"6.96E-12"},"0.003,0.012","0.076,0.057",-0.059]
[11370,"ENSG00000140497.16","SCAMP2","chr15","-",74848599,74848701,74848599,74848645,74850513,74850673,11370,11571195,"20,27",833781,"19,12",205,149,0.822388287908,1,"0.977,0.97","0.97,0.979",-1E-3]
[11371,"ENSG00000140497.16","SCAMP2","chr15","-",74848599,74848701,74848599,74848645,74851352,74851481,11371,365407,"3,0",259245,"3,2",205,149,0.725942685203,1,"0.989,1.0","0.984,0.989",0.008]
[11372,"ENSG00000140497.16","SCAMP2","chr15","-",74852068,74854119,74852068,74852186,74854580,74854649,11372,803887,"2,0",9181103,"0,0",298,149,1,1,"0.995,1.0","1.0,1.0",-2E-3]
[11373,"ENSG00000178761.14","FAM219B","chr15","-",74899991,74902063,74899991,74900137,74902603,74902786,11373,231245,"13,11",210261,"1,12",298,149,0.0706221667172,0.191959891375201,"0.899,0.918","0.991,0.916",-0.045]
[11374,"ENSG00000178761.14","FAM219B","chr15","-",74902603,74902786,74902603,74902783,74904663,74904712,11374,252243,"94,74",232212,"49,63",152,149,0.0795816391068,0.211800556197911,"0.724,0.763","0.823,0.767",-0.051]
[11375,"ENSG00000178761.14","FAM219B","chr15","-",74904981,74905059,74904981,74905039,74905153,74905231,11375,"49,42","12,12","15,17","2,0",169,149,1.38551632676E-3,0.00630284525387859,"0.783,0.755","0.869,1.0",-0.165]
[11376,"ENSG00000178761.14","FAM219B","chr15","-",74904663,74905231,74904663,74904712,74906277,74906365,11376,204198,"0,1",174183,"0,0",298,149,1,1,"1.0,0.99","1.0,1.0",-0.005]
[11377,"ENSG00000140400.16","MAN2C1","chr15","-",75356300,75356449,75356300,75356380,75356605,75356685,11377,519547,"65,70",450386,"52,76",218,149,0.279098323077,0.577485627065259,"0.845,0.842","0.855,0.776",0.028]
[11378,"ENSG00000140400.16","MAN2C1","chr15","-",75359058,75359191,75359058,75359153,75359619,75359775,11378,"138,90","3,1",109115,"1,1",187,149,0.543099323037,0.933708311845342,"0.973,0.986","0.989,0.989",-0.009]
[11379,"ENSG00000140400.16","MAN2C1","chr15","-",75359058,75359425,75359058,75359153,75359619,75359775,11379,633619,"3,1",492516,"1,1",298,149,1,1,"0.991,0.997","0.996,0.996",-2E-3]
[11380,"ENSG00000140400.16","MAN2C1","chr15","-",75359058,75359425,75359058,75359191,75359619,75359775,11380,499534,"1,0",384403,"0,0",298,149,1,1,"0.996,1.0","1.0,1.0",-2E-3]
[11381,"ENSG00000140400.16","MAN2C1","chr15","-",75359327,75359438,75359327,75359425,75359619,75359775,11381,"22,38",383438,"13,19",270266,162,149,0.370543399059,0.710829611010013,"0.05,0.074","0.042,0.062",0.01]
[11382,"ENSG00000140400.16","MAN2C1","chr15","-",75361854,75362025,75361854,75361947,75362342,75362453,11382,"9,8",253268,"18,46",245199,227,149,{"v":7.9980212675e-08,"d":"8.00E-08"},{"v":7.73950879479317e-07,"d":"7.74E-07"},"0.023,0.019","0.046,0.132",-0.068]
[11383,"ENSG00000140400.16","MAN2C1","chr15","-",75367510,75367645,75367510,75367634,75368072,75368198,11383,"19,7",422465,"34,24",339297,160,149,{"v":5.40206121402e-06,"d":"5.40E-06"},{"v":3.97156858580388e-05,"d":"3.97E-05"},"0.04,0.014","0.085,0.07",-0.051]
[11384,"ENSG00000140400.16","MAN2C1","chr15","-",75367510,75367977,75367510,75367634,75368072,75368198,11384,"27,10",422465,"37,40",339297,298,149,{"v":1.47485689961E-6,"d":"1.47E-06"},{"v":1.18517328182807E-5,"d":"1.19E-05"},"0.031,0.011","0.052,0.063",-0.036]
[11385,"ENSG00000140400.16","MAN2C1","chr15","-",75367510,75367977,75367510,75367645,75368072,75368198,11385,"24,10","16,7","36,38","33,22",298,149,0.788250105337,1,"0.429,0.417","0.353,0.463",0.015]
[11386,"ENSG00000140400.16","MAN2C1","chr15","-",75368072,75368198,75368072,75368159,75368482,75368612,11386,483577,"8,11",319292,"16,12",188,149,2.91095582E-3,0.0122665429955589,"0.98,0.977","0.94,0.951",0.033]
[11387,"ENSG00000272897.5","AL109827.1","chr20","-",35673600,35673684,35673600,35673616,35674349,35674400,11387,371322,"0,2",278296,"5,7",217,149,0.0153985858217,0.0524652720704018,"1.0,0.991","0.974,0.967",0.025]
[11388,"ENSG00000140391.14","TSPAN3","chr15","-",77055788,77055863,77055788,77055829,77056063,77056255,11388,14341410,"0,2",746667,"2,0",183,149,1,1,"1.0,0.998","0.997,1.0",1E-3]
[11389,"ENSG00000173517.10","PEAK1","chr15","-",77284957,77285078,77284957,77285055,77286422,77286504,11389,"27,10","7,0","25,17","2,0",172,149,0.0268283426398,0.0842117507614918,"0.77,1.0","0.915,1.0",-0.073]
[11390,"ENSG00000140382.14","HMG20A","chr15","+",77467094,77467307,77467182,77467307,77464239,77464387,11390,1032938,"13,13",966882,"10,15",237,149,0.959410859547,1,"0.98,0.978","0.984,0.974",0]
[11395,"ENSG00000104679.10","R3HCC1","chr8","+",23289015,23289153,23289042,23289153,23288505,23288633,11395,244244,"0,5",352406,"0,3",176,149,0.903563975385,1,"1.0,0.976","1.0,0.991",-0.008]
[11396,"ENSG00000086666.18","ZFAND6","chr15","+",80121711,80121820,80121747,80121820,80120327,80120498,11396,22002053,"52,33",22482320,"8,5",185,149,{"v":5.13592213203e-08,"d":"5.14E-08"},{"v":5.16269118071815e-07,"d":"5.16E-07"},"0.971,0.98","0.996,0.997",-0.021]
[11397,"ENSG00000172349.17","IL16","chr15","+",81291923,81293037,81292555,81293037,81290452,81290540,11397,"9,8","17,16","0,0","25,3",298,149,{"v":1.19172917235e-06,"d":"1.19E-06"},{"v":9.69873407880132e-06,"d":"9.70E-06"},"0.209,0.2","0.0,0.0",0.205]
[11398,"ENSG00000172349.17","IL16","chr15","+",81306419,81306545,81306422,81306545,81305907,81306166,11398,"35,36","25,39","43,42","20,27",152,149,0.0862662168849,0.225475143908891,"0.578,0.475","0.678,0.604",-0.115]
[11399,"ENSG00000167930.15","FAM234A","chr16","+",254380,254681,254387,254681,249548,249654,11399,190185,"5,2",131141,"1,0",156,149,0.603612131486,0.996170230132019,"0.973,0.989","0.992,1.0",-0.015]
[11400,"ENSG00000167930.15","FAM234A","chr16","+",259968,260160,259995,260160,259482,259599,11400,225209,"37,14",131169,"2,3",176,149,{"v":1.57162526326E-7,"d":"1.57E-07"},{"v":1.47090261239995E-6,"d":"1.47E-06"},"0.837,0.927","0.982,0.979",-0.098]
[11402,"ENSG00000063241.7","ISOC2","chr19","-",55455259,55455378,55455259,55455330,55455635,55455845,11402,"77,66",562572,89125,106117,197,149,0,0,"0.094,0.08","0.388,0.447",-0.331]
[11403,"ENSG00000063241.7","ISOC2","chr19","-",55455259,55455378,55455259,55455330,55456348,55456489,11403,"61,63",345370,157146,223295,197,149,{"v":2.75335310107e-14,"d":"2.75E-14"},{"v":5.46257350889318e-13,"d":"5.46E-13"},"0.118,0.114","0.347,0.272",-0.194]

{"sheet":"Proteomics","index":10,"n_rows":6984,"n_cols":65,"rows_kept":1125,"cut":true,"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
["Protein accession","Protein description","Gene name","Indi/Ctrl Ratio","Indi/Ctrl P value","Regulated Type","Intensity Ctrl1","Intensity Ctrl2","Intensity Ctrl3","Intensity Indi1","Intensity Indi2","Intensity Indi3","Ctrl1","Ctrl2","Ctrl3","Indi1","Indi2","Indi3","Subcellular localization","KEGG KO No.","KEGG Gene","KEGG pathway","Biological Process","Cellular Component","Molecular Function","Pfam ID","Domain description","KOG category","KOG NO.","KOG description","WikiPathways","externalDetailsURL","Is_TF","Reactome pathway","Reactome link","HallMark","msigdbURL"]
["A0A0B4J2F0","Protein PIGBOS1 OS=Homo sapiens OX=9606 GN=PIGBOS1 PE=1 SV=1","PIGBOS1",0.901244952,0.915845901,"nochange",1263.02,2636.05,3329.32,2513.57,1845.88,2155.1,0.551419129,1.150867282,1.453540509,1.097394007,0.805888696,0.940890377,"extracellular"]
["A0AVI4","E3 ubiquitin-protein ligase TM129 OS=Homo sapiens OX=9606 GN=TMEM129 PE=1 SV=1","TMEM129",1.267951816,0.128986393,"nochange",2357.05,2641.45,2842.35,2764.58,3187.08,3990.16,0.795285522,0.891244116,0.959029212,0.932789058,1.075343579,1.346308513,"plasma membrane","K22380",null,null,"GO:0000209 protein polyubiquitination; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0030970 retrograde protein transport"," ER to cytosol; GO:0032446 protein modification by small protein conjugation; GO:0032527 protein exit from endoplasmic reticulum; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034976 response to endoplasmic reticulum stress; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1903513 endoplasmic reticulum to cytosol transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"S","KOG3899","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654"]
["A0AVT1","Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1","UBA6",0.806308189,0.000550209,"down",33656.5,32693.5,32454.9,27287.5,25640.3,26739.4,1.131487779,1.099112971,1.091091549,0.917370278,0.861993555,0.898943869,"nucleus","K10699","UBE1L2; ubiquitin-activating enzyme E1-like protein 2 [EC:6.2.1.45]","hsa04120 Ubiquitin mediated proteolysis","GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021761 limbic system development; GO:0021764 amygdala development; GO:0021766 hippocampus development; GO:0022008 neurogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030900 forebrain development; GO:0031175 neuron projection development; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0060322 head development; GO:0060996 dendritic spine development; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0120036 plasma membrane bounded cell projection organization; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004839 ubiquitin activating enzyme activity; GO:0008641 ubiquitin-like modifier activating enzyme activity; GO:0016874 ligase activity; GO:0016877 ligase activity"," forming carbon-sulfur bonds; GO:0019780 FAT10 activating enzyme activity;","PF00899; PF16190; PF16191; PF10585; PF09358","PF00899 ThiF family; PF16190 Ubiquitin-activating enzyme E1 FCCH domain; PF16191 Ubiquitin-activating enzyme E1 four-helix bundle; PF10585 Ubiquitin-activating enzyme"," SCCH domain; PF09358 Ubiquitin fold domain","O","KOG2012","Ubiquitin activating enzyme UBA1",{"$nulls":3},"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8852135 Protein ubiquitination;R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866652;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["A0FGR8","Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1","ESYT2",0.879775812,0.098194122,"nochange",8465.88,7686.78,7150.97,6836.73,6441.94,7223.3,1.159561335,1.052848951,0.979459704,0.936418631,0.882344723,0.989366656,"nucleus",{"$nulls":3},"GO:0001505 regulation of neurotransmitter levels; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0009987 cellular process; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0023052 signaling; GO:0023061 signal release; GO:0032940 secretion by cell; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048489 synaptic vesicle transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0008021 synaptic vesicle; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030133 transport vesicle; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044232 organelle membrane contact site; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098793 presynapse; GO:0098827 endoplasmic reticulum subcompartment; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005544 calcium-dependent phospholipid binding; GO:0008289 lipid binding; GO:0008429 phosphatidylethanolamine binding; GO:0031210 phosphatidylcholine binding; GO:0035091 phosphatidylinositol binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0050997 quaternary ammonium group binding; GO:0070405 ammonium ion binding;","PF17047; PF00168","PF17047 Synaptotagmin-like mitochondrial-lipid-binding domain; PF00168 C2 domain","R","KOG1012","Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A"," contains C2 domain",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1660662 Glycosphingolipid metabolism;R-HSA-428157 Sphingolipid metabolism;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1660662;https://reactome.org/PathwayBrowser/#/R-HSA-428157;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["A1L0T0","2-hydroxyacyl-CoA lyase 2 OS=Homo sapiens OX=9606 GN=ILVBL PE=1 SV=2","ILVBL",0.873121637,0.011703448,"nochange",8224.03,7974.68,8057.12,7480.02,6899.1,6799.17,1.086059992,1.053130995,1.064017967,0.987806521,0.911090608,0.897893918,"endoplasmic reticulum","K11259",null,null,"GO:0001501 skeletal system development; GO:0007275 multicellular organism development; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0043009 chordate embryonic development; GO:0048513 animal organ development; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048598 embryonic morphogenesis; GO:0048701 embryonic cranial skeleton morphogenesis; GO:0048704 embryonic skeletal system morphogenesis; GO:0048705 skeletal system morphogenesis; GO:0048706 embryonic skeletal system development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:1904888 cranial skeletal system development;","GO:0016020 membrane;",null,"PF02776; PF00205; PF02775","PF02776 Thiamine pyrophosphate enzyme"," N-terminal TPP binding domain; PF00205 Thiamine pyrophosphate enzyme"," central domain; PF02775 Thiamine pyrophosphate enzyme"," C-terminal TPP binding domain","EH","KOG1185","Thiamine pyrophosphate-requiring enzyme",{"$nulls":5},"HYPOXIA","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA"]
["A1L390","Pleckstrin homology domain-containing family G member 3 OS=Homo sapiens OX=9606 GN=PLEKHG3 PE=1 SV=1","PLEKHG3",0.44598947,0.043873905,"nochange",6773.53,6675.22,6658.07,3947.98,1495.08,3524.37,1.397841045,1.377552989,1.374013775,0.814737439,0.308536936,0.727317816,"nucleus","K23859",null,null,"GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0023051 regulation of signaling; GO:0030100 regulation of endocytosis; GO:0032489 regulation of Cdc42 protein signal transduction; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0035023 regulation of Rho protein signal transduction; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0046578 regulation of Ras protein signal transduction; GO:0048513 animal organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0050764 regulation of phagocytosis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:1901074 regulation of engulfment of apoptotic cell; GO:1902531 regulation of intracellular signal transduction; GO:1905153 regulation of membrane invagination; GO:2000425 regulation of apoptotic cell clearance;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0055120 striated muscle dense body; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0098772 molecular function regulator;","PF00621; PF00169","PF00621 RhoGEF domain; PF00169 PH domain","R","KOG3518","Putative guanine nucleotide exchange factor",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013408 RHOG GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013408;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["A1X283","SH3 and PX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=SH3PXD2B PE=1 SV=3","SH3PXD2B",0.803818247,0.103937741,"nochange",2957.14,3396.03,3287.38,2203.83,3090.43,2454.99,1.020301556,1.171731705,1.134244212,0.760387123,1.066290584,0.847044819,"mitochondria","K24032",null,null,"GO:0000003 reproduction; GO:0001501 skeletal system development; GO:0001503 ossification; GO:0001649 osteoblast differentiation; GO:0001654 eye development; GO:0002051 osteoblast fate commitment; GO:0006801 superoxide metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0007507 heart development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0022411 cellular component disassembly; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022617 extracellular matrix disassembly; GO:0030154 cell differentiation; GO:0030198 extracellular matrix organization; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034613 cellular protein localization; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0043062 extracellular structure organization; GO:0043085 positive regulation of catalytic activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045598 regulation of fat cell differentiation; GO:0045600 positive regulation of fat cell differentiation; GO:0045927 positive regulation of growth; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048705 skeletal system morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051496 positive regulation of stress fiber assembly; GO:0051641 cellular localization; GO:0060255 regulation of macromolecule metabolic process; GO:0060348 bone development; GO:0060378 regulation of brood size; GO:0060612 adipose tissue development; GO:0061448 connective tissue development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071800 podosome assembly; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072593 reactive oxygen species metabolic process; GO:0072657 protein localization to membrane; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1904177 regulation of adipose tissue development; GO:1904179 positive regulation of adipose tissue development; GO:1904888 cranial skeletal system development; GO:2000026 regulation of multicellular organismal development;","GO:0002102 podosome; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0015629 actin cytoskeleton; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008047 enzyme activator activity; GO:0008289 lipid binding; GO:0010314 phosphatidylinositol-5-phosphate binding; GO:0016176 superoxide-generating NADPH oxidase activator activity; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0042169 SH2 domain binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0070273 phosphatidylinositol-4-phosphate binding; GO:0080025 phosphatidylinositol-3","5-bisphosphate binding; GO:0098772 molecular function regulator; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00787; PF00018; PF07653","PF00787 PX domain; PF00018 SH3 domain; PF07653 Variant SH3 domain","T","KOG0905","Phosphoinositide 3-kinase"]
["A1Z1Q3","ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2","MACROD2",3.269250133,0.210558736,"nochange",614.41,249.623,"NA",1309.44,1579.56,1348.11,0.602227775,0.244673596,"NA",1.283477056,1.548241247,1.321380326,"nucleus","K23518",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009116 nucleoside metabolic process; GO:0009987 cellular process; GO:0019538 protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0042278 purine nucleoside metabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0051725 protein de-ADP-ribosylation; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060322 head development; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901657 glycosyl compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0019213 deacetylase activity;","PF01661","PF01661 Macro domain","BK","KOG2633","Hismacro and SEC14 domain-containing proteins"]
["A2RRP1","NBAS subunit of NRZ tethering complex OS=Homo sapiens OX=9606 GN=NBAS PE=1 SV=2","NBAS",0.743551246,0.000695723,"down",16072,16308.4,16307.3,12712.3,12072.7,11416.8,1.13597088,1.15267966,1.152601912,0.898506882,0.853299878,0.806940788,"nucleus","K20473",null,null,"GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048193 Golgi vesicle transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061013 regulation of mRNA catabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902369 negative regulation of RNA catabolic process; GO:1902373 negative regulation of mRNA catabolic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:2000622 regulation of nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0070939 Dsl1/NZR complex; GO:0099023 vesicle tethering complex;","GO:0000149 SNARE binding; GO:0005488 binding; GO:0005515 protein binding;",null,null,"S","KOG1797","Uncharacterized conserved protein (Neuroblastoma-amplified protein)",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688"]
["A2RTX5","Threonine--tRNA ligase 2"," cytoplasmic OS=Homo sapiens OX=9606 GN=TARS3 PE=1 SV=1","TARS3",0.755813634,0.005439947,"down",8003.64,6777.4,7080.5,5502.43,5415.57,5605.25,1.251064289,1.059388367,1.106766508,0.860095366,0.846518113,0.876167357,"cytoplasm","K01868","TARS; threonyl-tRNA synthetase [EC:6.1.1.3]","hsa00970 Aminoacyl-tRNA biosynthesis","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006435 threonyl-tRNA aminoacylation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0048856 anatomical structure development; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015629 actin cytoskeleton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004812 aminoacyl-tRNA ligase activity; GO:0004829 threonine-tRNA ligase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016874 ligase activity; GO:0016875 ligase activity"," forming carbon-oxygen bonds; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF02824; PF07973; PF00587; PF03129","PF02824 TGS domain; PF07973 Threonyl and Alanyl tRNA synthetase second additional domain; PF00587 tRNA synthetase class II core domain (G"," H"," P"," S and T); PF03129 Anticodon binding domain","J","KOG1637","Threonyl-tRNA synthetase"]
["A2RUC4","tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1","TYW5",0.933714772,0.121639185,"nochange",6501.29,6716.6,6355.4,5716.27,6317.6,6242,1.030610455,1.064742256,1.007483389,0.906165949,1.001491182,0.989506768,"cytoplasm","K18066",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006400 tRNA modification; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0031590 wybutosine metabolic process; GO:0031591 wybutosine biosynthetic process; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901657 glycosyl compound metabolic process; GO:1901659 glycosyl compound biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;","GO:0000049 tRNA binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005506 iron ion binding; GO:0005515 protein binding; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046983 protein dimerization activity; GO:0051213 dioxygenase activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF13621","PF13621 Cupin-like domain","BT","KOG2132","Uncharacterized conserved protein"," contains JmjC domain",{"$nulls":3},"R-HSA-6782315 tRNA modification in the nucleus and cytosol;R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe);R-HSA-72306 tRNA processing;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6782315;https://reactome.org/PathwayBrowser/#/R-HSA-6782861;https://reactome.org/PathwayBrowser/#/R-HSA-72306;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["A2VDJ0","Transmembrane protein 131-like OS=Homo sapiens OX=9606 GN=TMEM131L PE=1 SV=2","TMEM131L",0.909703922,0.757818642,"nochange",2596.58,2583.29,1597.39,2095.07,2015.13,"NA",1.192463623,1.186360271,0.733591673,0.962148196,0.925436236,"NA","plasma membrane",{"$nulls":3},"GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0007162 negative regulation of cell adhesion; GO:0008285 negative regulation of cell population proliferation; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030155 regulation of cell adhesion; GO:0030178 negative regulation of Wnt signaling pathway; GO:0032944 regulation of mononuclear cell proliferation; GO:0032945 negative regulation of mononuclear cell proliferation; GO:0033081 regulation of T cell differentiation in thymus; GO:0033083 regulation of immature T cell proliferation; GO:0033084 regulation of immature T cell proliferation in thymus; GO:0033085 negative regulation of T cell differentiation in thymus; GO:0033087 negative regulation of immature T cell proliferation; GO:0033088 negative regulation of immature T cell proliferation in thymus; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042130 negative regulation of T cell proliferation; GO:0045580 regulation of T cell differentiation; GO:0045581 negative regulation of T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045620 negative regulation of lymphocyte differentiation; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050670 regulation of lymphocyte proliferation; GO:0050672 negative regulation of lymphocyte proliferation; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050868 negative regulation of T cell activation; GO:0051093 negative regulation of developmental process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051250 negative regulation of lymphocyte activation; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065007 biological regulation; GO:0070663 regulation of leukocyte proliferation; GO:0070664 negative regulation of leukocyte proliferation; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:1902105 regulation of leukocyte differentiation; GO:1902106 negative regulation of leukocyte differentiation; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903038 negative regulation of leukocyte cell-cell adhesion; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;",null,"PF12371","PF12371 Transmembrane protein 131-like N-terminal","S","KOG3620","Uncharacterized conserved protein"]
["A3KMH1","von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2","VWA8",0.740513011,{"v":4.98999E-5,"d":"4.99E-05"},"down",10419.2,10506.7,10067.6,7781.84,7641.39,7527.86,1.158878027,1.168610235,1.119771232,0.865537026,0.849915441,0.837288039,"mitochondria","K24512",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity;","PF07728","PF07728 AAA domain (dynein-related subfamily)","R","KOG1808","AAA ATPase containing von Willebrand factor type A (vWA) domain"]
["A4D126","D-ribitol-5-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CRPPA PE=1 SV=2","CRPPA",0.728380951,1.17495E-4,"down",18032.5,17682.8,17916.8,12665.1,12851.4,13548.1,1.167193654,1.144558544,1.159704714,0.819776756,0.831835438,0.876930894,"cytoplasm","K21031","ISPD; D-ribitol-5-phosphate cytidylyltransferase [EC:2.7.7.40]","hsa00515 Mannose type O-glycan biosynthesis; hsa00040 Pentose and glucuronate interconversions; hsa01100 Metabolic pathways","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0034645 cellular macromolecule biosynthetic process; GO:0035268 protein mannosylation; GO:0035269 protein O-linked mannosylation; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042692 muscle cell differentiation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048854 brain morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0060049 regulation of protein glycosylation; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0061061 muscle structure development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0097485 neuron projection guidance; GO:0097502 mannosylation; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903018 regulation of glycoprotein metabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity; GO:0070567 cytidylyltransferase activity;","PF18706","PF18706 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain"]
["A4D1E9","GTP-binding protein 10 OS=Homo sapiens OX=9606 GN=GTPBP10 PE=1 SV=1","GTPBP10",0.814267613,0.013105659,"nochange",10481.8,10794.5,10923.9,8368.49,8269.8,9581.29,1.07653264,1.108648475,1.121938494,0.859485263,0.849349313,0.984045815,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",null,"PF01018","PF01018 GTP1/OBG","R","KOG1489","Predicted GTP-binding protein (ODN superfamily)"]
["A4D1P6","WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2","WDR91",0.581743976,0.009253915,"down",6393.3,6558.56,5551.95,3997.13,2882.04,3885.31,1.31062662,1.344504923,1.138149854,0.819411725,0.590818254,0.796488623,"nucleus","K24760",null,null,"GO:0006810 transport; GO:0006950 response to stress; GO:0009611 response to wounding; GO:0009894 regulation of catabolic process; GO:0016192 vesicle-mediated transport; GO:0016482 cytosolic transport; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0042060 wound healing; GO:0042176 regulation of protein catabolic process; GO:0042325 regulation of phosphorylation; GO:0043549 regulation of kinase activity; GO:0043550 regulation of lipid kinase activity; GO:0043551 regulation of phosphatidylinositol 3-kinase activity; GO:0045022 early endosome to late endosome transport; GO:0046907 intracellular transport; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0080090 regulation of primary metabolic process; GO:0098927 vesicle-mediated transport between endosomal compartments; GO:1903362 regulation of cellular protein catabolic process; GO:1903725 regulation of phospholipid metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0031090 organelle membrane; GO:0031312 extrinsic component of organelle membrane; GO:0031313 extrinsic component of endosome membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle;","GO:0019207 kinase regulator activity; GO:0030234 enzyme regulator activity; GO:0035014 phosphatidylinositol 3-kinase regulator activity; GO:0098772 molecular function regulator;",null,null,"S","KOG1333","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["A5D8V6","Vacuolar protein sorting-associated protein 37C OS=Homo sapiens OX=9606 GN=VPS37C PE=1 SV=2","VPS37C",1.006902537,0.879081569,"nochange",3605,6560.74,5722.62,6071.95,4646.3,5279.78,0.67834584,1.234521688,1.076814277,1.142547024,0.874285236,0.993485936,"nucleus","K12185","VPS37; ESCRT-I complex subunit VPS37","hsa04144 Endocytosis","GO:0006810 transport; GO:0006914 autophagy; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0019058 viral life cycle; GO:0019068 virion assembly; GO:0022607 cellular component assembly; GO:0036257 multivesicular body organization; GO:0036258 multivesicular body assembly; GO:0039702 viral budding via host ESCRT complex; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0046755 viral budding; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061919 process utilizing autophagic mechanism; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis;","GO:0000813 ESCRT I complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036452 ESCRT complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0048306 calcium-dependent protein binding;","PF07200","PF07200 Modifier of rudimentary (Mod(r)) protein","S","KOG3270","Uncharacterized conserved protein","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4932_r118797",null,"R-HSA-162587 HIV Life Cycle;R-HSA-162588 Budding and maturation of HIV virion;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-174490 Membrane binding and targetting of GAG proteins;R-HSA-174495 Synthesis And Processing Of GAG"," GAGPOL Polyproteins;R-HSA-175474 Assembly Of The HIV Virion;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT);R-HSA-9609646 HCMV Infection;R-HSA-9610379 HCMV Late Events;R-HSA-9612973 Autophagy;R-HSA-9615710 Late endosomal microautophagy","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162588;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-174490;https://reactome.org/PathwayBrowser/#/R-HSA-174495;https://reactome.org/PathwayBrowser/#/R-HSA-175474;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-917729;https://reactome.org/PathwayBrowser/#/R-HSA-9609646;https://reactome.org/PathwayBrowser/#/R-HSA-9610379;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9615710"]
["A5YKK6","CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2","CNOT1",0.864537888,0.002765259,"down",33640.6,35514.6,35067.3,30886.5,29364.2,29853.6,1.038681232,1.096542525,1.082731769,0.953646126,0.90664386,0.921754488,"cytoplasm","K12604","CNOT1; CCR4-NOT transcription complex subunit 1","hsa03018 RNA degradation","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000288 nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0001701 in utero embryonic development; GO:0001824 blastocyst development; GO:0001825 blastocyst formation; GO:0001829 trophectodermal cell differentiation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006977 DNA damage response"," signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010603 regulation of cytoplasmic mRNA processing body assembly; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010948 negative regulation of cell cycle process; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016441 posttranscriptional gene silencing; GO:0017148 negative regulation of translation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0030953 astral microtubule organization; GO:0031047 gene silencing by RNA; GO:0031122 cytoplasmic microtubule organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033043 regulation of organelle organization; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway; GO:0033146 regulation of intracellular estrogen receptor signaling pathway; GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway; GO:0033554 cellular response to stress; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035194 post-transcriptional gene silencing by RNA; GO:0035195 gene silencing by miRNA; GO:0035556 intracellular signal transduction; GO:0040001 establishment of mitotic spindle localization; GO:0040007 growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042770 signal transduction in response to DNA damage; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044703 multi-organism reproductive process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048385 regulation of retinoic acid receptor signaling pathway; GO:0048387 negative regulation of retinoic acid receptor signaling pathway; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051293 establishment of spindle localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening; GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0061013 regulation of mRNA catabolic process; GO:0061014 positive regulation of mRNA catabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090503 RNA phosphodiester bond hydrolysis"," exonucleolytic; GO:0097435 supramolecular fiber organization; GO:1900151 regulation of nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1903311 regulation of mRNA metabolic process; GO:1903313 positive regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000036 regulation of stem cell population maintenance; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2001141 regulation of RNA biosynthetic process;","GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030014 CCR4-NOT complex; GO:0030015 CCR4-NOT core complex; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:1990904 ribonucleoprotein complex;","GO:0000175 3'-5'-exoribonuclease activity; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004527 exonuclease activity; GO:0004532 exoribonuclease activity; GO:0004535 poly(A)-specific ribonuclease activity; GO:0004540 ribonuclease activity; GO:0005102 signaling receptor binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008408 3'-5' exonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016796 exonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; GO:0016896 exoribonuclease activity"," producing 5'-phosphomonoesters; GO:0019904 protein domain specific binding; GO:0030331 estrogen receptor binding; GO:0042974 retinoic acid receptor binding; GO:0051427 hormone receptor binding; GO:0070016 armadillo repeat domain binding; GO:0140098 catalytic activity"," acting on RNA;","PF16418; PF16417; PF16415; PF12842","PF16418 CCR4-NOT transcription complex subunit 1 HEAT repeat; PF16417 CCR4-NOT transcription complex subunit 1 TTP binding domain; PF16415 CCR4-NOT transcription complex subunit 1 CAF1-binding domain; PF12842 CCR4-Not complex"," Not1 subunit"," domain of unknown function DUF3819","K","KOG1831","Negative regulator of transcription","WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP4352_r102218",null,"R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-429914 Deadenylation-dependent mRNA decay;R-HSA-429947 Deadenylation of mRNA;R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes;R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-429914;https://reactome.org/PathwayBrowser/#/R-HSA-429947;https://reactome.org/PathwayBrowser/#/R-HSA-6791312;https://reactome.org/PathwayBrowser/#/R-HSA-6804115;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["A6NC98","Coiled-coil domain-containing protein 88B OS=Homo sapiens OX=9606 GN=CCDC88B PE=1 SV=1","CCDC88B",0.903324968,0.180080765,"nochange",9592.18,10220.6,10424.5,10157,8852.4,8304.69,1.000029713,1.065545442,1.086802973,1.058914844,0.922904181,0.865802847,"nucleus","K25813",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0001562 response to protozoan; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006810 transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0008284 positive regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0030155 regulation of cell adhesion; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031122 cytoplasmic microtubule organization; GO:0032944 regulation of mononuclear cell proliferation; GO:0032946 positive regulation of mononuclear cell proliferation; GO:0042102 positive regulation of T cell proliferation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042832 defense response to protozoan; GO:0043207 response to external biotic stimulus; GO:0045785 positive regulation of cell adhesion; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050670 regulation of lymphocyte proliferation; GO:0050671 positive regulation of lymphocyte proliferation; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051707 response to other organism; GO:0065007 biological regulation; GO:0070663 regulation of leukocyte proliferation; GO:0070665 positive regulation of leukocyte proliferation; GO:0071840 cellular component organization or biogenesis; GO:0097435 supramolecular fiber organization; GO:0098542 defense response to other organism; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0051959 dynein light intermediate chain binding;","PF19047","PF19047 HOOK domain","S","KOG4643","Uncharacterized coiled-coil protein"]
["A6NDG6","Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1","PGP",0.941702549,0.406012878,"nochange",32342.1,30133.7,32857.7,31226,26329.8,32220,1.048313618,0.976732125,1.065025906,1.012137154,0.853435241,1.044355956,"extracellular","K19269","PGP; phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48]","hsa01200 Carbon metabolism; hsa00630 Glyoxylate and dicarboxylate metabolism; hsa01100 Metabolic pathways","GO:0005975 carbohydrate metabolic process; GO:0006066 alcohol metabolic process; GO:0006071 glycerol metabolic process; GO:0006109 regulation of carbohydrate metabolic process; GO:0006111 regulation of gluconeogenesis; GO:0006114 glycerol biosynthetic process; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010677 negative regulation of cellular carbohydrate metabolic process; GO:0010906 regulation of glucose metabolic process; GO:0016051 carbohydrate biosynthetic process; GO:0016311 dephosphorylation; GO:0019222 regulation of metabolic process; GO:0019400 alditol metabolic process; GO:0019401 alditol biosynthetic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0034637 cellular carbohydrate biosynthetic process; GO:0035335 peptidyl-tyrosine dephosphorylation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043255 regulation of carbohydrate biosynthetic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045721 negative regulation of gluconeogenesis; GO:0045912 negative regulation of carbohydrate metabolic process; GO:0046165 alcohol biosynthetic process; GO:0046173 polyol biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0062012 regulation of small molecule metabolic process; GO:0062014 negative regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004035 alkaline phosphatase activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004725 protein tyrosine phosphatase activity; GO:0005488 binding; GO:0008967 phosphoglycolate phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0043136 glycerol-3-phosphatase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0098519 nucleotide phosphatase activity"," acting on free nucleotides; GO:0140096 catalytic activity"," acting on a protein;","PF13344; PF13242","PF13344 Haloacid dehalogenase-like hydrolase; PF13242 HAD-hyrolase-like","P","KOG2882","p-Nitrophenyl phosphatase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-70171 Glycolysis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70171;https://reactome.org/PathwayBrowser/#/R-HSA-70326;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["A6NED2","RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1","RCCD1",0.648045365,3.819635E-3,"down",10674.8,12311.6,10766.7,8118.51,6918.58,6836.45,1.151405154,1.327953657,1.161317671,0.875678632,0.746251796,0.737393091,"nucleus",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;",{"$nulls":3},"S","KOG1426","FOG: RCC1 domain"]
["A6NGU5","Putative glutathione hydrolase 3 proenzyme OS=Homo sapiens OX=9606 GN=GGT3P PE=5 SV=2","GGT3P",1.019341598,0.734493347,"nochange",7624.73,7907.28,6530.8,7470.73,7285.33,7733.48,1.026845497,1.064897362,0.879522629,1.006105851,0.981137471,1.04149119,"plasma membrane","K18592","GGT1_5; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]","hsa00480 Glutathione metabolism; hsa00590 Arachidonic acid metabolism; hsa00430 Taurine and hypotaurine metabolism; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000096 sulfur amino acid metabolic process; GO:0000097 sulfur amino acid biosynthetic process; GO:0002682 regulation of immune system process; GO:0006082 organic acid metabolic process; GO:0006412 translation; GO:0006508 proteolysis; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006534 cysteine metabolic process; GO:0006536 glutamate metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006690 icosanoid metabolic process; GO:0006691 leukotriene metabolic process; GO:0006749 glutathione metabolic process; GO:0006750 glutathione biosynthetic process; GO:0006751 glutathione catabolic process; GO:0006790 sulfur compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0008152 metabolic process; GO:0008652 cellular amino acid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009064 glutamine family amino acid metabolic process; GO:0009069 serine family amino acid metabolic process; GO:0009070 serine family amino acid biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016053 organic acid biosynthetic process; GO:0016485 protein processing; GO:0019184 nonribosomal peptide biosynthetic process; GO:0019344 cysteine biosynthetic process; GO:0019370 leukotriene biosynthetic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0031179 peptide modification; GO:0031347 regulation of defense response; GO:0031638 zymogen activation; GO:0032101 regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0032787 monocarboxylic acid metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0042219 cellular modified amino acid catabolic process; GO:0042221 response to chemical; GO:0042398 cellular modified amino acid biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043171 peptide catabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043648 dicarboxylic acid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044273 sulfur compound catabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0046394 carboxylic acid biosynthetic process; GO:0046456 icosanoid biosynthetic process; GO:0048232 male gamete generation; GO:0048583 regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0050727 regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051604 protein maturation; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071466 cellular response to xenobiotic stimulus; GO:0071704 organic substance metabolic process; GO:0080134 regulation of response to stress; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901607 alpha-amino acid biosynthetic process; GO:1901748 leukotriene D4 metabolic process; GO:1901750 leukotriene D4 biosynthetic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery;","GO:0000048 peptidyltransferase activity; GO:0002951 leukotriene-C(4) hydrolase; GO:0003824 catalytic activity; GO:0008233 peptidase activity; GO:0008238 exopeptidase activity; GO:0008242 omega peptidase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016755 aminoacyltransferase activity; GO:0016787 hydrolase activity; GO:0036374 glutathione hydrolase activity; GO:0070122 isopeptidase activity; GO:0140096 catalytic activity"," acting on a protein;","PF01019","PF01019 Gamma-glutamyltranspeptidase","E","KOG2410","Gamma-glutamyltransferase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-174403 Glutathione synthesis and recycling;R-HSA-211859 Biological oxidations;R-HSA-5423646 Aflatoxin activation and detoxification;R-HSA-9748784 Drug ADME;R-HSA-9753281 Paracetamol ADME","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-174403;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-5423646;https://reactome.org/PathwayBrowser/#/R-HSA-9748784;https://reactome.org/PathwayBrowser/#/R-HSA-9753281"]
["A6NHR9","Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2","SMCHD1",0.738181611,0.000123889,"down",24896.5,25512,24984.6,19067,17874.4,18712.4,1.139889612,1.168070363,1.143923282,0.872985168,0.818381816,0.856749759,"cytoplasm","K23113",null,null,"GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0007549 dosage compensation; GO:0009048 dosage compensation by inactivation of X chromosome; GO:0010468 regulation of gene expression; GO:0019222 regulation of metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0040029 regulation of gene expression"," epigenetic; GO:0043584 nose development; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0060255 regulation of macromolecule metabolic process; GO:0060541 respiratory system development; GO:0065007 biological regulation;","GO:0000228 nuclear chromosome; GO:0000803 sex chromosome; GO:0000805 X chromosome; GO:0001740 Barr body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity;","PF13589; PF06470","PF13589 Histidine kinase-"," DNA gyrase B-"," and HSP90-like ATPase; PF06470 SMC proteins Flexible Hinge Domain",{"$nulls":5},"Transcription factor"]
["A6NIH7","Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1","UNC119B",0.9241701,0.498344464,"nochange",15717.8,12742.9,15616.9,11493.9,15355.7,13885.6,1.11194065,0.90148421,1.104802577,0.813124906,1.086324234,0.982323423,"cytoplasm","K23539",null,null,"GO:0000003 reproduction; GO:0001558 regulation of cell growth; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0006810 transport; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007631 feeding behavior; GO:0007635 chemosensory behavior; GO:0008104 protein localization; GO:0008361 regulation of cell size; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010721 negative regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030308 negative regulation of cell growth; GO:0030516 regulation of axon extension; GO:0030517 negative regulation of axon extension; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0033036 macromolecule localization; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040024 dauer larval development; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0042953 lipoprotein transport; GO:0043051 regulation of pharyngeal pumping; GO:0044085 cellular component biogenesis; GO:0044782 cilium organization; GO:0044872 lipoprotein localization; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045926 negative regulation of growth; GO:0046662 regulation of oviposition; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050771 negative regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060259 regulation of feeding behavior; GO:0060271 cilium assembly; GO:0060284 regulation of cell development; GO:0061387 regulation of extent of cell growth; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070121 Kupffer's vesicle development; GO:0070925 organelle assembly; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1903998 regulation of eating behavior; GO:2000026 regulation of multicellular organismal development; GO:2000241 regulation of reproductive process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005929 cilium; GO:0030424 axon; GO:0035869 ciliary transition zone; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0008289 lipid binding;",null,null,"UT","KOG4037","Photoreceptor synaptic vesicle protein HRG4/UNC-119",{"$nulls":3},"R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-5617833 Cilium Assembly;R-HSA-5620920 Cargo trafficking to the periciliary membrane;R-HSA-5624138 Trafficking of myristoylated proteins to the cilium","https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620920;https://reactome.org/PathwayBrowser/#/R-HSA-5624138"]
["A6NJ78","12S rRNA N4-methylcytidine (m4C) methyltransferase OS=Homo sapiens OX=9606 GN=METTL15 PE=1 SV=1","METTL15",1.355795386,0.044929788,"nochange",2581.56,2628.78,3421.7,3661.14,3684.45,4357.69,0.761697382,0.775629791,1.009583326,1.08023085,1.087108538,1.285750114,"nucleus","K25876",null,null,"GO:0000154 rRNA modification; GO:0001510 RNA methylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0031167 rRNA methylation; GO:0032259 methylation; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0070475 rRNA base methylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;",null,"GO:0003824 catalytic activity; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008649 rRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016434 rRNA (cytosine) methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity; GO:0140098 catalytic activity"," acting on RNA; GO:0140102 catalytic activity"," acting on a rRNA;",null,null,"R","KOG2782","Putative SAM dependent methyltransferases"]
["A6NK58","Putative lipoyltransferase 2"," mitochondrial OS=Homo sapiens OX=9606 GN=LIPT2 PE=1 SV=1","LIPT2",0.874237892,0.573529413,"nochange",1006.84,"NA",1503.63,1064.92,922.892,1304.31,0.8675778,"NA",1.295653735,0.9176244,0.795241161,1.123902904,"mitochondria","K23735","LIPT2; lipoyl(octanoyl) transferase 2 [EC:2.3.1.181]","hsa01240 Biosynthesis of cofactors; hsa00785 Lipoic acid metabolism; hsa01100 Metabolic pathways","GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009249 protein lipoylation; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051604 protein maturation; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:2000374 regulation of oxygen metabolic process; GO:2000376 positive regulation of oxygen metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0033819 lipoyl(octanoyl) transferase activity;",null,null,"CH","KOG0325","Lipoyltransferase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-389661 Glyoxylate metabolism and glycine degradation;R-HSA-71291 Metabolism of amino acids and derivatives","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-389661;https://reactome.org/PathwayBrowser/#/R-HSA-71291"]
["A7E2V4","Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZSWIM8 PE=1 SV=1","ZSWIM8",0.626725939,0.058797095,"nochange",2333.45,2685.54,3246.8,1948.93,"NA",1504.66,0.995551812,1.145768803,1.385226864,0.831498765,"NA",0.641953755,"plasma membrane","K25207",null,null,"GO:0003008 system process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007600 sensory perception; GO:0009987 cellular process; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0019233 sensory perception of pain; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0030154 cell differentiation; GO:0031344 regulation of cell projection organization; GO:0032101 regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0046662 regulation of oviposition; GO:0048518 positive regulation of biological process; GO:0048520 positive regulation of behavior; GO:0048583 regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050877 nervous system process; GO:0050920 regulation of chemotaxis; GO:0051128 regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051960 regulation of nervous system development; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901046 positive regulation of oviposition; GO:1902435 regulation of male mating behavior; GO:1902667 regulation of axon guidance; GO:2000026 regulation of multicellular organismal development; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030424 axon; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031462 Cul2-RING ubiquitin ligase complex; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0044297 cell body; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0031072 heat shock protein binding; GO:0051787 misfolded protein binding; GO:0051879 Hsp90 protein binding;",null,null,"S","KOG3615","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-376176 Signaling by ROBO receptors;R-HSA-422475 Axon guidance;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9675108 Nervous system development","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-9010553;https://reactome.org/PathwayBrowser/#/R-HSA-9675108"]
["A8CG34","Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3","POM121C",1.017445909,0.831262076,"nochange",4905.23,5629.28,5551.21,5085.08,5210.65,6070.62,0.906918418,1.040786612,1.026352402,0.940170535,0.963386927,1.122385105,"plasma membrane","K14316","POM121; nuclear pore complex protein Nup121","hsa03013 Nucleocytoplasmic transport; hsa05014 Amyotrophic lateral sclerosis","GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006606 protein import into nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006999 nuclear pore organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005048 signal sequence binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0008139 nuclear localization sequence binding; GO:0017056 structural constituent of nuclear pore; GO:0033218 amide binding; GO:0042277 peptide binding;",{"$nulls":8},"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1430728 Metabolism;R-HSA-159227 Transport of the SLBP independent Mature mRNA;R-HSA-159230 Transport of the SLBP Dependant Mature mRNA;R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript;R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts;R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-165054 Rev-mediated nuclear export of HIV RNA;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus;R-HSA-168276 NS1 Mediated Effects on Host Pathways;R-HSA-168325 Viral Messenger RNA Synthesis;R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery;R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein;R-HSA-176033 Interactions of Vpr with host cellular proteins;R-HSA-177243 Interactions of Rev with host cellular proteins;R-HSA-180746 Nuclear import of Rev protein;R-HSA-180910 Vpr-mediated nuclear import of PICs;R-HSA-191859 snRNP Assembly;R-HSA-194441 Metabolism of non-coding RNA;R-HSA-211000 Gene Silencing by RNA;R-HSA-2262752 Cellular responses to stress;R-HSA-2980766 Nuclear Envelope Breakdown;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3232142 SUMOylation of ubiquitinylation proteins;R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly;R-HSA-3371453 Regulation of HSF1-mediated heat shock response;R-HSA-3371556 Cellular response to heat stress;R-HSA-392499 Metabolism of proteins;R-HSA-4085377 SUMOylation of SUMOylation proteins;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-4570464 SUMOylation of RNA binding proteins;R-HSA-4615885 SUMOylation of DNA replication proteins;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-5619102 SLC transporter disorders;R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-6784531 tRNA processing in the nucleus;R-HSA-68875 Mitotic Prophase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-70171 Glycolysis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-72306 tRNA processing;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-913531 Interferon Signaling;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9610379 HCMV Late Events;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions"]
["A8MXV4","Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1","NUDT19",1.020038881,0.72732491,"nochange",37070.4,31956.2,37246.8,34685.6,38106.6,35610.8,1.036082215,0.893145218,1.041012426,0.969429336,1.065043014,0.995287791,"mitochondria","K13355","NUDT19; nucleoside diphosphate-linked moiety X motif 19"," mitochondrial [EC:3.6.1.-]","hsa04146 Peroxisome","GO:0006082 organic acid metabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0016192 vesicle-mediated transport; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045184 establishment of protein localization; GO:0046395 carboxylic acid catabolic process; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0098657 import into cell; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005782 peroxisomal matrix; GO:0005829 cytosol; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016289 CoA hydrolase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016790 thiolester hydrolase activity; GO:0047617 acyl-CoA hydrolase activity;",null,null,"S","KOG3904","Predicted hydrolase RP2 (NUDIX/MutT superfamily)",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-390918 Peroxisomal lipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-390918;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["A9UHW6","MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1","MIF4GD",0.566347719,2.72954E-4,"down",6006.86,6049.53,5615.28,3168.32,3612.02,3227.97,1.30206597,1.311315254,1.217185851,0.686775063,0.782952878,0.699704985,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding;",null,null,"J","KOG3942","MIF4G domain-containing protein"]
["B0I1T2","Unconventional myosin-Ig OS=Homo sapiens OX=9606 GN=MYO1G PE=1 SV=2","MYO1G",0.780549592,{"v":4.25727E-5,"d":"4.26E-05"},"down",66766.3,68719.9,66150.7,52991.6,52451.6,51944.4,1.115795162,1.14844363,1.105507284,0.885593044,0.876568591,0.868092289,"cytoplasm","nucleus","K10356","MYO1; myosin I","hsa05130 Pathogenic Escherichia coli infection","GO:0000003 reproduction; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002443 leukocyte mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002456 T cell mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006955 immune response; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007368 determination of left/right symmetry; GO:0007389 pattern specification process; GO:0007444 imaginal disc development; GO:0007483 genital disc morphogenesis; GO:0007484 imaginal disc-derived genitalia development; GO:0007485 imaginal disc-derived male genitalia development; GO:0007498 mesoderm development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009799 specification of symmetry; GO:0009855 determination of bilateral symmetry; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0016482 cytosolic transport; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0022610 biological adhesion; GO:0023052 signaling; GO:0030539 male genitalia development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031589 cell-substrate adhesion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0035112 genitalia morphogenesis; GO:0035126 post-embryonic genitalia morphogenesis; GO:0035215 genital disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035303 regulation of dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0040011 locomotion; GO:0043086 negative regulation of catalytic activity; GO:0044092 negative regulation of molecular function; GO:0045936 negative regulation of phosphate metabolic process; GO:0046661 male sex differentiation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048565 digestive tract development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048803 imaginal disc-derived male genitalia morphogenesis; GO:0048805 imaginal disc-derived genitalia morphogenesis; GO:0048806 genitalia development; GO:0048808 male genitalia morphogenesis; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0055123 digestive system development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061458 reproductive system development; GO:0061502 early endosome to recycling endosome transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071907 determination of digestive tract left/right asymmetry; GO:0071976 cell gliding; GO:0072676 lymphocyte migration; GO:0072678 T cell migration; GO:0090598 male anatomical structure morphogenesis; GO:0098657 import into cell; GO:0098927 vesicle-mediated transport between endosomal compartments; GO:0120117 T cell meandering migration;","GO:0001891 phagocytic cup; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005902 microvillus; GO:0005903 brush border; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016459 myosin complex; GO:0030027 lamellipodium; GO:0030175 filopodium; GO:0030424 axon; GO:0030425 dendrite; GO:0031252 cell leading edge; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0071944 cell periphery; GO:0097440 apical dendrite; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0003774 cytoskeletal motor activity; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019904 protein domain specific binding; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043325 phosphatidylinositol-3","4-bisphosphate binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00063; PF06017","PF00063 Myosin head (motor domain); PF06017 Unconventional myosin tail"," actin- and lipid-binding","Z","KOG0164","Myosin class I heavy chain"]
["B2RUZ4","Small integral membrane protein 1 OS=Homo sapiens OX=9606 GN=SMIM1 PE=1 SV=1","SMIM1",1.011157567,0.965528212,"nochange",13435,13443.4,13757.7,12956.1,12109.6,16023.8,0.986349443,0.98696614,1.010040917,0.951190325,0.889043335,1.17640984,"plasma membrane"]
["B7ZAQ6","Golgi pH regulator A OS=Homo sapiens OX=9606 GN=GPR89A PE=1 SV=2","GPR89A",0.721530987,0.004991722,"down",11056.1,11424.6,13046.7,8990.78,8485.87,8157.47,1.084613332,1.120763513,1.279892978,0.882003587,0.832471462,0.800255128,"plasma membrane","K22193",null,null,"GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006873 cellular ion homeostasis; GO:0006885 regulation of pH; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007275 multicellular organism development; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015698 inorganic anion transport; GO:0016043 cellular component organization; GO:0019725 cellular homeostasis; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030641 regulation of cellular pH; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0034220 ion transmembrane transport; GO:0042592 homeostatic process; GO:0043588 skin development; GO:0045851 pH reduction; GO:0046903 secretion; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051452 intracellular pH reduction; GO:0051453 regulation of intracellular pH; GO:0055067 monovalent inorganic cation homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0098656 anion transmembrane transport; GO:0098771 inorganic ion homeostasis;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005798 Golgi-associated vesicle; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0032580 Golgi cisterna membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005244 voltage-gated ion channel activity; GO:0005253 anion channel activity; GO:0008308 voltage-gated anion channel activity; GO:0008509 anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015267 channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022803 passive transmembrane transporter activity; GO:0022832 voltage-gated channel activity; GO:0022836 gated channel activity; GO:0022839 ion gated channel activity; GO:0022857 transmembrane transporter activity;",null,null,"T","KOG2417","Predicted G-protein coupled receptor"]
["C4AMC7","Putative WAS protein family homolog 3 OS=Homo sapiens OX=9606 GN=WASH3P PE=1 SV=2","WASH3P",0.779821528,0.02855096,"nochange",9156.85,11137.8,11503.1,8134.62,8148.9,8513.05,0.970788235,1.18080401,1.219532278,0.862413755,0.863927687,0.902534035,"cytoplasm","nucleus","K18461","WASH1; WAS protein family homolog 1","hsa04144 Endocytosis","GO:0006810 transport; GO:0006887 exocytosis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0008064 regulation of actin polymerization or depolymerization; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022411 cellular component disassembly; GO:0022617 extracellular matrix disassembly; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030198 extracellular matrix organization; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031272 regulation of pseudopodium assembly; GO:0031274 positive regulation of pseudopodium assembly; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031396 regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033673 negative regulation of kinase activity; GO:0034314 Arp2/3 complex-mediated actin nucleation; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043062 extracellular structure organization; GO:0043086 negative regulation of catalytic activity; GO:0043254 regulation of protein-containing complex assembly; GO:0043549 regulation of kinase activity; GO:0043550 regulation of lipid kinase activity; GO:0043551 regulation of phosphatidylinositol 3-kinase activity; GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0045010 actin nucleation; GO:0045833 negative regulation of lipid metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060491 regulation of cell projection assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090219 negative regulation of lipid kinase activity; GO:0097435 supramolecular fiber organization; GO:0098876 vesicle-mediated transport to the plasma membrane; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903725 regulation of phospholipid metabolic process; GO:1903726 negative regulation of phospholipid metabolic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005773 vacuole; GO:0005776 autophagosome; GO:0012505 endomembrane system; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0055037 recycling endosome; GO:0071203 WASH complex; GO:0097708 intracellular vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0043014 alpha-tubulin binding; GO:0044389 ubiquitin-like protein ligase binding;","PF11945","PF11945 WAHD domain of WASH complex","O","KOG1366","Alpha-macroglobulin"]
["C9JLW8","Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1","MCRIP1",1.128852182,0.369560932,"nochange",18620.5,24156.2,22303.3,20373.6,27268.5,25823.6,0.806398178,1.046132792,0.965889234,0.882319697,1.180917199,1.118342901,"nucleus",{"$nulls":3},"GO:0010717 regulation of epithelial to mesenchymal transition; GO:0045595 regulation of cell differentiation; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051239 regulation of multicellular organismal process; GO:0065007 biological regulation; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0010494 cytoplasmic stress granule; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:1990904 ribonucleoprotein complex;"]
["C9JRZ8","Aldo-keto reductase family 1 member B15 OS=Homo sapiens OX=9606 GN=AKR1B15 PE=1 SV=2","AKR1B15",1.289679774,0.069352072,"nochange",15533.6,14562.4,13804.2,16277.9,17963.1,22376.2,0.927218571,0.869246519,0.823988683,0.9716467,1.072238239,1.335661288,"cytoplasm",{"$nulls":3},"GO:0001523 retinoid metabolic process; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006000 fructose metabolic process; GO:0006066 alcohol metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006629 lipid metabolic process; GO:0006694 steroid biosynthetic process; GO:0006700 C21-steroid hormone biosynthetic process; GO:0006703 estrogen biosynthetic process; GO:0006714 sesquiterpenoid metabolic process; GO:0006720 isoprenoid metabolic process; GO:0006721 terpenoid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006970 response to osmotic stress; GO:0006972 hyperosmotic response; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008207 C21-steroid hormone metabolic process; GO:0008210 estrogen metabolic process; GO:0008300 isoprenoid catabolic process; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009628 response to abiotic stimulus; GO:0009651 response to salt stress; GO:0009987 cellular process; GO:0010817 regulation of hormone levels; GO:0016042 lipid catabolic process; GO:0016051 carbohydrate biosynthetic process; GO:0016093 polyprenol metabolic process; GO:0016095 polyprenol catabolic process; GO:0016101 diterpenoid metabolic process; GO:0016107 sesquiterpenoid catabolic process; GO:0016115 terpenoid catabolic process; GO:0016137 glycoside metabolic process; GO:0016487 farnesol metabolic process; GO:0016488 farnesol catabolic process; GO:0016999 antibiotic metabolic process; GO:0017001 antibiotic catabolic process; GO:0019318 hexose metabolic process; GO:0019319 hexose biosynthetic process; GO:0019748 secondary metabolic process; GO:0022900 electron transport chain; GO:0030638 polyketide metabolic process; GO:0030647 aminoglycoside antibiotic metabolic process; GO:0033554 cellular response to stress; GO:0034308 primary alcohol metabolic process; GO:0034310 primary alcohol catabolic process; GO:0034754 cellular hormone metabolic process; GO:0042180 cellular ketone metabolic process; GO:0042445 hormone metabolic process; GO:0042446 hormone biosynthetic process; GO:0042538 hyperosmotic salinity response; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0044597 daunorubicin metabolic process; GO:0044598 doxorubicin metabolic process; GO:0046164 alcohol catabolic process; GO:0046364 monosaccharide biosynthetic process; GO:0046370 fructose biosynthetic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071214 cellular response to abiotic stimulus; GO:0071470 cellular response to osmotic stress; GO:0071472 cellular response to salt stress; GO:0071474 cellular hyperosmotic response; GO:0071475 cellular hyperosmotic salinity response; GO:0071704 organic substance metabolic process; GO:0097164 ammonium ion metabolic process; GO:0104004 cellular response to environmental stimulus; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901616 organic hydroxy compound catabolic process; GO:1901657 glycosyl compound metabolic process; GO:1901661 quinone metabolic process; GO:1902644 tertiary alcohol metabolic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0001758 retinal dehydrogenase activity; GO:0003824 catalytic activity; GO:0004032 alditol:NADP+ 1-oxidoreductase activity; GO:0004033 aldo-keto reductase (NADP) activity; GO:0004303 estradiol 17-beta-dehydrogenase activity; GO:0008106 alcohol dehydrogenase (NADP+) activity; GO:0009055 electron transfer activity; GO:0016229 steroid dehydrogenase activity; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor; GO:0016620 oxidoreductase activity"," acting on the aldehyde or oxo group of donors"," NAD or NADP as acceptor; GO:0016903 oxidoreductase activity"," acting on the aldehyde or oxo group of donors; GO:0033764 steroid dehydrogenase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor; GO:0043795 glyceraldehyde oxidoreductase activity; GO:0045550 geranylgeranyl reductase activity; GO:0047718 indanol dehydrogenase activity;","PF00248","PF00248 Aldo/keto reductase family","R","KOG1577","Aldo/keto reductase family proteins",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-193144 Estrogen biosynthesis;R-HSA-196071 Metabolism of steroid hormones;R-HSA-556833 Metabolism of lipids;R-HSA-8957322 Metabolism of steroids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-193144;https://reactome.org/PathwayBrowser/#/R-HSA-196071;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8957322"]
["O00116","Alkyldihydroxyacetonephosphate synthase"," peroxisomal OS=Homo sapiens OX=9606 GN=AGPS PE=1 SV=1","AGPS",0.877208158,1.247347E-3,"down",48947,49489.3,50001.9,44082.6,42118.6,44010,1.05394808,1.065625119,1.076662645,0.949205704,0.906916003,0.94764245,"cytoplasm","K00803","AGPS; alkyldihydroxyacetonephosphate synthase [EC:2.5.1.26]","hsa00565 Ether lipid metabolism; hsa04146 Peroxisome; hsa01100 Metabolic pathways","GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006662 glycerol ether metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008611 ether lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0018904 ether metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043574 peroxisomal transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0045184 establishment of protein localization; GO:0046485 ether lipid metabolic process; GO:0046504 glycerol ether biosynthetic process; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0097384 cellular lipid biosynthetic process; GO:1901503 ether biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005782 peroxisomal matrix; GO:0005829 cytosol; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031903 microbody membrane; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0008609 alkylglycerone-phosphate synthase activity; GO:0016740 transferase activity; GO:0016765 transferase activity"," transferring alkyl or aryl (other than methyl) groups; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0050660 flavin adenine dinucleotide binding; GO:0071949 FAD binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF01565; PF02913","PF01565 FAD binding domain ; PF02913 FAD linked oxidases"," C-terminal domain","R","KOG1233","Alkyl-dihydroxyacetonephosphate synthase","WP2533 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY;WP325 TRIACYLGLYCERIDE SYNTHESIS","http://www.wikipathways.org/instance/WP2533_r120261;http://www.wikipathways.org/instance/WP325_r116669",null,"R-HSA-1430728 Metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-75896 Plasmalogen biosynthesis;R-HSA-8848584 Wax and plasmalogen biosynthesis;R-HSA-9033241 Peroxisomal protein import;R-HSA-9033500 TYSND1 cleaves peroxisomal proteins;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-75896;https://reactome.org/PathwayBrowser/#/R-HSA-8848584;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9033500;https://reactome.org/PathwayBrowser/#/R-HSA-9609507"]
["O00139","Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3","KIF2A",0.581007498,{"v":2.50775e-05,"d":"2.51E-05"},"down",63507.6,61917.2,65771.7,38313.5,36519,36254.1,1.260558728,1.228990969,1.30549872,0.760482475,0.724863547,0.719605562,"cytoplasm","nucleus","K10393",null,null,"GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000212 meiotic spindle organization; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0001578 microtubule bundle formation; GO:0001709 cell fate determination; GO:0002376 immune system process; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007019 microtubule depolymerization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007056 spindle assembly involved in female meiosis; GO:0007057 spindle assembly involved in female meiosis I; GO:0007059 chromosome segregation; GO:0007079 mitotic chromosome movement towards spindle pole; GO:0007127 meiosis I; GO:0007143 female meiotic nuclear division; GO:0007144 female meiosis I; GO:0007163 establishment or maintenance of cell polarity; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007288 sperm axoneme assembly; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007610 behavior; GO:0008104 protein localization; GO:0009794 regulation of mitotic cell cycle"," embryonic; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010938 cytoplasmic microtubule depolymerization; GO:0010968 regulation of microtubule nucleation; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0018991 oviposition; GO:0019098 reproductive behavior; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030010 establishment of cell polarity; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030154 cell differentiation; GO:0030317 flagellated sperm motility; GO:0030334 regulation of cell migration; GO:0030953 astral microtubule organization; GO:0031023 microtubule organizing center organization; GO:0031109 microtubule polymerization or depolymerization; GO:0031110 regulation of microtubule polymerization or depolymerization; GO:0031111 negative regulation of microtubule polymerization or depolymerization; GO:0031113 regulation of microtubule polymerization; GO:0031115 negative regulation of microtubule polymerization; GO:0031122 cytoplasmic microtubule organization; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032465 regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032954 regulation of cytokinetic process; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0035082 axoneme assembly; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0043254 regulation of protein-containing complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044380 protein localization to cytoskeleton; GO:0044703 multi-organism reproductive process; GO:0044782 cilium organization; GO:0045165 cell fate commitment; GO:0045167 asymmetric protein localization involved in cell fate determination; GO:0045995 regulation of embryonic development; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048193 Golgi vesicle transport; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048515 spermatid differentiation; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050000 chromosome localization; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051261 protein depolymerization; GO:0051270 regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051295 establishment of meiotic spindle localization; GO:0051296 establishment of meiotic spindle orientation; GO:0051302 regulation of cell division; GO:0051303 establishment of chromosome localization; GO:0051305 chromosome movement towards spindle pole; GO:0051321 meiotic cell cycle; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051649 establishment of localization in cell; GO:0051651 maintenance of location in cell; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051657 maintenance of organelle location; GO:0051661 maintenance of centrosome location; GO:0051674 localization of cell; GO:0051726 regulation of cell cycle; GO:0060271 cilium assembly; GO:0060491 regulation of cell projection assembly; GO:0061842 microtubule organizing center localization; GO:0061867 establishment of mitotic spindle asymmetry; GO:0061982 meiosis I cell cycle process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070462 plus-end specific microtubule depolymerization; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071539 protein localization to centrosome; GO:0071840 cellular component organization or biogenesis; GO:0072698 protein localization to microtubule cytoskeleton; GO:0090306 meiotic spindle assembly; GO:0090307 mitotic spindle assembly; GO:0097435 supramolecular fiber organization; GO:0097722 sperm motility; GO:0098534 centriole assembly; GO:0098813 nuclear chromosome segregation; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1902017 regulation of cilium assembly; GO:1902115 regulation of organelle assembly; GO:1902412 regulation of mitotic cytokinesis; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903436 regulation of mitotic cytokinetic process; GO:1905503 regulation of motile cilium assembly; GO:1905508 protein localization to microtubule organizing center; GO:1905515 non-motile cilium assembly; GO:1905833 negative regulation of microtubule nucleation; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility;","GO:0000235 astral microtubule; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005814 centriole; GO:0005815 microtubule organizing center; GO:0005818 aster; GO:0005819 spindle; GO:0005828 kinetochore microtubule; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005871 kinesin complex; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005876 spindle microtubule; GO:0005881 cytoplasmic microtubule; GO:0005929 cilium; GO:0005938 cell cortex; GO:0015630 microtubule cytoskeleton; GO:0016604 nuclear body; GO:0030863 cortical cytoskeleton; GO:0030981 cortical microtubule cytoskeleton; GO:0031514 motile cilium; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0036126 sperm flagellum; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055028 cortical microtubule; GO:0061673 mitotic spindle astral microtubule; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0072687 meiotic spindle; GO:0090619 meiotic spindle pole; GO:0097228 sperm principal piece; GO:0097431 mitotic spindle pole; GO:0097729 9+2 motile cilium; GO:0098687 chromosomal region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0120103 centriolar subdistal appendage;","GO:0003774 cytoskeletal motor activity; GO:0003777 microtubule motor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008574 plus-end-directed microtubule motor activity; GO:0015631 tubulin binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding;","PF00225","PF00225 Kinesin motor domain","Z","KOG0246","Kinesin-like protein",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-1280218 Adaptive Immune System;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199991 Membrane Trafficking;R-HSA-2132295 MHC class II antigen presentation;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-983189 Kinesins;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2132295;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9716542;https://reactome.org/PathwayBrowser/#/R-HSA-983189;https://reactome.org/PathwayBrowser/#/R-HSA-983231","COMPLEMENT;GLYCOLYSIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS"]
["O00148","ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2","DDX39A",1.369449388,0.000164175,"up",698527,689224,719742,925819,981153,979133,0.839307049,0.828129137,0.864797687,1.112407126,1.178893055,1.176465947,"cytoplasm","K13182",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0008380 RNA splicing; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010501 RNA secondary structure unwinding; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048518 positive regulation of biological process; GO:0048856 anatomical structure development; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903311 regulation of mRNA metabolic process;","GO:0000346 transcription export complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005681 spliceosomal complex; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003724 RNA helicase activity; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008186 ATP-dependent activity"," acting on RNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0042802 identical protein binding; GO:0140098 catalytic activity"," acting on RNA;","PF00270; PF00271","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain","A","KOG0329","ATP-dependent RNA helicase",{"$nulls":3},"R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","E2F TARGETS;G2M CHECKPOINT;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["O00151","PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4","PDLIM1",0.986763979,0.567851182,"nochange",210788,218419,204216,206680,206754,211605,1.004979094,1.041361599,0.973645609,0.985393282,0.985746093,1.008874324,"cytoplasm","K23353",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005667 transcription regulator complex; GO:0032991 protein-containing complex;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0140110 transcription regulator activity;","PF00595; PF00412","PF00595 PDZ domain; PF00412 LIM domain","TZ","KOG1703","Adaptor protein Enigma and related PDZ-LIM proteins",{"$nulls":5},"REACTIVE OXYGEN SPECIES PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"]
["O00154","Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3","ACOT7",0.998229558,0.946878752,"nochange",162756,152314,158258,156931,155867,159692,1.032477707,0.966236633,1.003943676,0.995525566,0.988775853,1.013040564,"mitochondria","K17360","ACOT7; acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]","hsa00062 Fatty acid elongation; hsa01040 Biosynthesis of unsaturated fatty acids","GO:0001676 long-chain fatty acid metabolic process; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006195 purine nucleotide catabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009154 purine ribonucleotide catabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009166 nucleotide catabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009261 ribonucleotide catabolic process; GO:0009987 cellular process; GO:0015936 coenzyme A metabolic process; GO:0015937 coenzyme A biosynthetic process; GO:0016053 organic acid biosynthetic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033869 nucleoside bisphosphate catabolic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034031 ribonucleoside bisphosphate catabolic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034034 purine nucleoside bisphosphate catabolic process; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035336 long-chain fatty-acyl-CoA metabolic process; GO:0035337 fatty-acyl-CoA metabolic process; GO:0035383 thioester metabolic process; GO:0036112 medium-chain fatty-acyl-CoA metabolic process; GO:0036114 medium-chain fatty-acyl-CoA catabolic process; GO:0036115 fatty-acyl-CoA catabolic process; GO:0036116 long-chain fatty-acyl-CoA catabolic process; GO:0042759 long-chain fatty acid biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044273 sulfur compound catabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0051791 medium-chain fatty acid metabolic process; GO:0051792 medium-chain fatty acid biosynthetic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072523 purine-containing compound catabolic process; GO:0090407 organophosphate biosynthetic process; GO:1900533 palmitic acid metabolic process; GO:1900535 palmitic acid biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901569 fatty acid derivative catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000062 fatty-acyl-CoA binding; GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016289 CoA hydrolase activity; GO:0016290 palmitoyl-CoA hydrolase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016790 thiolester hydrolase activity; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0033218 amide binding; GO:0036042 long-chain fatty acyl-CoA binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046983 protein dimerization activity; GO:0047617 acyl-CoA hydrolase activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1901567 fatty acid derivative binding; GO:1901681 sulfur compound binding;",null,null,"I","KOG2763","Acyl-CoA thioesterase","WP5064 7OXOC AND 7BETAHC PATHWAYS;WP4545 OXYSTEROLS DERIVED FROM CHOLESTEROL","http://www.wikipathways.org/instance/WP5064_r120384;http://www.wikipathways.org/instance/WP4545_r120411",null,"R-HSA-1430728 Metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-77289;https://reactome.org/PathwayBrowser/#/R-HSA-8978868"]
["O00159","Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4","MYO1C",0.736003321,0.004176533,"down",5603.25,5505.74,5293.83,3689.24,4382.4,4000.89,1.18065274,1.160106548,1.115455297,0.777354449,0.923409194,0.843021771,"cytoplasm","K10356","MYO1; myosin I","hsa05130 Pathogenic Escherichia coli infection","GO:0000003 reproduction; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0003006 developmental process involved in reproduction; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007368 determination of left/right symmetry; GO:0007389 pattern specification process; GO:0007444 imaginal disc development; GO:0007483 genital disc morphogenesis; GO:0007484 imaginal disc-derived genitalia development; GO:0007485 imaginal disc-derived male genitalia development; GO:0007498 mesoderm development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009799 specification of symmetry; GO:0009855 determination of bilateral symmetry; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030048 actin filament-based movement; GO:0030050 vesicle transport along actin filament; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030539 male genitalia development; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032528 microvillus organization; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0034097 response to cytokine; GO:0034341 response to interferon-gamma; GO:0034613 cellular protein localization; GO:0035112 genitalia morphogenesis; GO:0035126 post-embryonic genitalia morphogenesis; GO:0035215 genital disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035924 cellular response to vascular endothelial growth factor stimulus; GO:0038084 vascular endothelial growth factor signaling pathway; GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0042221 response to chemical; GO:0042742 defense response to bacterium; GO:0042886 amide transport; GO:0043207 response to external biotic stimulus; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045087 innate immune response; GO:0045184 establishment of protein localization; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0046661 male sex differentiation; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048803 imaginal disc-derived male genitalia morphogenesis; GO:0048805 imaginal disc-derived genitalia morphogenesis; GO:0048806 genitalia development; GO:0048808 male genitalia morphogenesis; GO:0048856 anatomical structure development; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0071363 cellular response to growth factor stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090150 establishment of protein localization to membrane; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090313 regulation of protein targeting to membrane; GO:0090314 positive regulation of protein targeting to membrane; GO:0090316 positive regulation of intracellular protein transport; GO:0090598 male anatomical structure morphogenesis; GO:0098542 defense response to other organism; GO:0098657 import into cell; GO:0099515 actin filament-based transport; GO:0099518 vesicle cytoskeletal trafficking; GO:0110053 regulation of actin filament organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900078 positive regulation of cellular response to insulin stimulus; GO:1900746 regulation of vascular endothelial growth factor signaling pathway; GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway; GO:1901888 regulation of cell junction assembly; GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903533 regulation of protein targeting; GO:1903829 positive regulation of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000810 regulation of bicellular tight junction assembly;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005886 plasma membrane; GO:0005902 microvillus; GO:0005903 brush border; GO:0005938 cell cortex; GO:0009925 basal plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016328 lateral plasma membrane; GO:0016459 myosin complex; GO:0016461 unconventional myosin complex; GO:0016604 nuclear body; GO:0030139 endocytic vesicle; GO:0030659 cytoplasmic vesicle membrane; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031941 filamentous actin; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032420 stereocilium; GO:0032421 stereocilium bundle; GO:0032587 ruffle membrane; GO:0032589 neuron projection membrane; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045121 membrane raft; GO:0045178 basal part of cell; GO:0045335 phagocytic vesicle; GO:0060171 stereocilium membrane; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098857 membrane microdomain; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0000146 microfilament motor activity; GO:0000166 nucleotide binding; GO:0003774 cytoskeletal motor activity; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0005524 ATP binding; GO:0005543 phospholipid binding; GO:0008022 protein C-terminus binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019899 enzyme binding; GO:0030554 adenyl nucleotide binding; GO:0031267 small GTPase binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding; GO:0051020 GTPase binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00063; PF06017","PF00063 Myosin head (motor domain); PF06017 Unconventional myosin tail"," actin- and lipid-binding","Z","KOG0164","Myosin class I heavy chain","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP481 INSULIN SIGNALING;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-199991 Membrane Trafficking;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-9658195 Leishmania infection;R-HSA-9659379 Sensory processing of sound;R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea;R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9709957 Sensory Perception","https://reactome.org/PathwayBrowser/#/R-HSA-1445148;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9659379;https://reactome.org/PathwayBrowser/#/R-HSA-9662360;https://reactome.org/PathwayBrowser/#/R-HSA-9662361;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9709957","IL2 STAT5 SIGNALING;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["O00160","Unconventional myosin-If OS=Homo sapiens OX=9606 GN=MYO1F PE=1 SV=3","MYO1F",0.73514691,1.167873E-3,"down",16795.5,16864,18627.6,13145.8,12820.5,12472.4,1.110742479,1.115272613,1.231905368,0.869375635,0.84786246,0.824841445,"cytoplasm","K10356","MYO1; myosin I","hsa05130 Pathogenic Escherichia coli infection","GO:0001655 urogenital system development; GO:0001775 cell activation; GO:0001822 kidney development; GO:0002064 epithelial cell development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002682 regulation of immune system process; GO:0003008 system process; GO:0003014 renal system process; GO:0003094 glomerular filtration; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007162 negative regulation of cell adhesion; GO:0007275 multicellular organism development; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009888 tissue development; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0030029 actin filament-based process; GO:0030048 actin filament-based movement; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030198 extracellular matrix organization; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030855 epithelial cell differentiation; GO:0031347 regulation of defense response; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032835 glomerulus development; GO:0032836 glomerular basement membrane development; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0035850 epithelial cell differentiation involved in kidney development; GO:0036230 granulocyte activation; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042119 neutrophil activation; GO:0042742 defense response to bacterium; GO:0043062 extracellular structure organization; GO:0043207 response to external biotic stimulus; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045088 regulation of innate immune response; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050830 defense response to Gram-positive bacterium; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051493 regulation of cytoskeleton organization; GO:0051707 response to other organism; GO:0060429 epithelium development; GO:0061005 cell differentiation involved in kidney development; GO:0061318 renal filtration cell differentiation; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0072001 renal system development; GO:0072006 nephron development; GO:0072009 nephron epithelium development; GO:0072010 glomerular epithelium development; GO:0072015 glomerular visceral epithelial cell development; GO:0072073 kidney epithelium development; GO:0072112 glomerular visceral epithelial cell differentiation; GO:0072310 glomerular epithelial cell development; GO:0072311 glomerular epithelial cell differentiation; GO:0080134 regulation of response to stress; GO:0097205 renal filtration; GO:0098542 defense response to other organism; GO:0098657 import into cell; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0016459 myosin complex; GO:0016461 unconventional myosin complex; GO:0030054 cell junction; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0031941 filamentous actin; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region;","GO:0000146 microfilament motor activity; GO:0000166 nucleotide binding; GO:0003774 cytoskeletal motor activity; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0005524 ATP binding; GO:0005543 phospholipid binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035091 phosphatidylinositol binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00063; PF06017; PF00018","PF00063 Myosin head (motor domain); PF06017 Unconventional myosin tail"," actin- and lipid-binding; PF00018 SH3 domain","Z","KOG0162","Myosin class I heavy chain"]
["O00161","Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1","SNAP23",0.676346784,{"v":2.94663e-05,"d":"2.95E-05"},"down",40273,42867.5,42033.6,28165.6,28227.3,28268.2,1.151560844,1.225747634,1.201903208,0.805363447,0.807127689,0.808297178,"cytoplasm","K08508","SNAP23; synaptosomal-associated protein 23","hsa04130 SNARE interactions in vesicular transport; hsa04611 Platelet activation","GO:0001505 regulation of neurotransmitter levels; GO:0001775 cell activation; GO:0001821 histamine secretion; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002279 mast cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002349 histamine production involved in inflammatory response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002441 histamine secretion involved in inflammatory response; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002448 mast cell mediated immunity; GO:0002474 antigen processing and presentation of peptide antigen via MHC class I; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I"," TAP-dependent; GO:0002532 production of molecular mediator involved in inflammatory response; GO:0002553 histamine secretion by mast cell; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006903 vesicle targeting; GO:0006906 vesicle fusion; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0008104 protein localization; GO:0009914 hormone transport; GO:0009987 cellular process; GO:0010817 regulation of hormone levels; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016082 synaptic vesicle priming; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0017157 regulation of exocytosis; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0023061 signal release; GO:0031503 protein-containing complex localization; GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane; GO:0032418 lysosome localization; GO:0032501 multicellular organismal process; GO:0032594 protein transport within lipid bilayer; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0035418 protein localization to synapse; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I; GO:0042886 amide transport; GO:0043299 leukocyte degranulation; GO:0043303 mast cell degranulation; GO:0043312 neutrophil degranulation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045026 plasma membrane fusion; GO:0045055 regulated exocytosis; GO:0045117 azole transmembrane transport; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0045576 mast cell activation; GO:0046879 hormone secretion; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048193 Golgi vesicle transport; GO:0048284 organelle fusion; GO:0048489 synaptic vesicle transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051608 histamine transport; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051668 localization within membrane; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane; GO:0090174 organelle membrane fusion; GO:0097120 receptor localization to synapse; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098876 vesicle-mediated transport to the plasma membrane; GO:0098877 neurotransmitter receptor transport to plasma membrane; GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane; GO:0098916 anterograde trans-synaptic signaling; GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane; GO:0098969 neurotransmitter receptor transport to postsynaptic membrane; GO:0099003 vesicle-mediated transport in synapse; GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels; GO:0099500 vesicle fusion to plasma membrane; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099632 protein transport within plasma membrane; GO:0099637 neurotransmitter receptor transport; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:1903530 regulation of secretion by cell; GO:1903539 protein localization to postsynaptic membrane; GO:1903540 establishment of protein localization to postsynaptic membrane; GO:1990778 protein localization to cell periphery;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030054 cell junction; GO:0030139 endocytic vesicle; GO:0030141 secretory granule; GO:0030424 axon; GO:0030659 cytoplasmic vesicle membrane; GO:0030666 endocytic vesicle membrane; GO:0030667 secretory granule membrane; GO:0030670 phagocytic vesicle membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0035579 specific granule membrane; GO:0042581 specific granule; GO:0042582 azurophil granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0045335 phagocytic vesicle; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0070820 tertiary granule; GO:0070821 tertiary granule membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098793 presynapse; GO:0098796 membrane protein complex; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0000149 SNARE binding; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019905 syntaxin binding;",null,null,"U","KOG3065","SNAP-25 (synaptosome-associated protein) component of SNARE complex","WP481 INSULIN SIGNALING","http://www.wikipathways.org/instance/WP481_r120562",null,"R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1280218 Adaptive Immune System;R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane;R-HSA-162582 Signal Transduction;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6798695 Neutrophil degranulation;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013409 RHOJ GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9035034 RHOF GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1236974;https://reactome.org/PathwayBrowser/#/R-HSA-1236975;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1445148;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013409;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9035034;https://reactome.org/PathwayBrowser/#/R-HSA-9716542;https://reactome.org/PathwayBrowser/#/R-HSA-983169","PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O00165","HCLS1-associated protein X-1 OS=Homo sapiens OX=9606 GN=HAX1 PE=1 SV=2","HAX1",1.005439122,0.871813772,"nochange",31912,32685.8,29093.8,31234,30787.6,32179.6,1.01904916,1.043758994,0.929055291,0.997398517,0.98314358,1.027594458,"cytoplasm","nucleus","K16220",null,null,"GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0002763 positive regulation of myeloid leukocyte differentiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008064 regulation of actin polymerization or depolymerization; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030852 regulation of granulocyte differentiation; GO:0030854 positive regulation of granulocyte differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032386 regulation of intracellular transport; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033135 regulation of peptidyl-serine phosphorylation; GO:0033138 positive regulation of peptidyl-serine phosphorylation; GO:0033157 regulation of intracellular protein transport; GO:0034097 response to cytokine; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045639 positive regulation of myeloid cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051223 regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051716 cellular response to stimulus; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0110053 regulation of actin filament organization; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1903146 regulation of autophagy of mitochondrion; GO:1903214 regulation of protein targeting to mitochondrion; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903533 regulation of protein targeting; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1903747 regulation of establishment of protein localization to mitochondrion; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000249 regulation of actin cytoskeleton reorganization; GO:2000251 positive regulation of actin cytoskeleton reorganization; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005758 mitochondrial intermembrane space; GO:0005783 endoplasmic reticulum; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0016528 sarcoplasm; GO:0016529 sarcoplasmic reticulum; GO:0019867 outer membrane; GO:0030027 lamellipodium; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045177 apical part of cell; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0019838 growth factor binding; GO:0019904 protein domain specific binding; GO:0019955 cytokine binding; GO:0019966 interleukin-1 binding; GO:0047485 protein N-terminus binding;",{"$nulls":7},"Transcription factor",null,null,"GLYCOLYSIS;IL6 JAK STAT3 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL6_JAK_STAT3_SIGNALING"]
["O00170","AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3","AIP",1.141253254,0.001221563,"up",85122.4,84374.6,86470.2,94581.1,98905.7,98636.6,0.93184302,0.923656782,0.946597515,1.03538831,1.082730118,1.079784255,"cytoplasm","K17767","AIP; AH receptor-interacting protein","hsa04934 Cushing syndrome; hsa05207 Chemical carcinogenesis - receptor activation","GO:0003008 system process; GO:0006457 protein folding; GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007600 sensory perception; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009410 response to xenobiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010738 regulation of protein kinase A signaling; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019233 sensory perception of pain; GO:0019538 protein metabolic process; GO:0022417 protein maturation by protein folding; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034097 response to cytokine; GO:0034613 cellular protein localization; GO:0035722 interleukin-12-mediated signaling pathway; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity; GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051604 protein maturation; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070585 protein localization to mitochondrion; GO:0070671 response to interleukin-12; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071349 cellular response to interleukin-12; GO:0071466 cellular response to xenobiotic stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034751 aryl hydrocarbon receptor complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043235 receptor complex; GO:0070013 intracellular organelle lumen;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0017162 aryl hydrocarbon receptor binding; GO:0019904 protein domain specific binding; GO:0036004 GAF domain binding; GO:0051082 unfolded protein binding; GO:0140110 transcription regulator activity;","PF00254","PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase","O","KOG0545","Aryl-hydrocarbon receptor-interacting protein","WP2586 ARYL HYDROCARBON RECEPTOR PATHWAY WP2586;WP2873 ARYL HYDROCARBON RECEPTOR PATHWAY WP2873;WP2882 NUCLEAR RECEPTORS METAPATHWAY","http://www.wikipathways.org/instance/WP2586_r120796;http://www.wikipathways.org/instance/WP2873_r120645;http://www.wikipathways.org/instance/WP2882_r117808","Transcription factor","R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1430728 Metabolism;R-HSA-168256 Immune System;R-HSA-211859 Biological oxidations;R-HSA-211945 Phase I - Functionalization of compounds;R-HSA-447115 Interleukin-12 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-8937144 Aryl hydrocarbon receptor signalling;R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;R-HSA-9020591 Interleukin-12 signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-211945;https://reactome.org/PathwayBrowser/#/R-HSA-447115;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-8937144;https://reactome.org/PathwayBrowser/#/R-HSA-8950505;https://reactome.org/PathwayBrowser/#/R-HSA-9020591"]
["O00186","Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2","STXBP3",0.618809468,1.538745E-3,"down",15268.3,16519.3,16127.1,8813.07,10733.2,10103.8,1.181074862,1.277845599,1.247507083,0.681732441,0.830263533,0.781576481,"cytoplasm","K15301",null,null,"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002790 peptide secretion; GO:0006810 transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008104 protein localization; GO:0009306 protein secretion; GO:0009611 response to wounding; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009914 hormone transport; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010817 regulation of hormone levels; GO:0010827 regulation of glucose transmembrane transport; GO:0010829 negative regulation of glucose transmembrane transport; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0017157 regulation of exocytosis; GO:0017158 regulation of calcium ion-dependent exocytosis; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0022615 protein to membrane docking; GO:0023052 signaling; GO:0023061 signal release; GO:0030072 peptide hormone secretion; GO:0030073 insulin secretion; GO:0030168 platelet activation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034097 response to cytokine; GO:0034109 homotypic cell-cell adhesion; GO:0034341 response to interferon-gamma; GO:0034762 regulation of transmembrane transport; GO:0034763 negative regulation of transmembrane transport; GO:0036230 granulocyte activation; GO:0042060 wound healing; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043434 response to peptide hormone; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045055 regulated exocytosis; GO:0045087 innate immune response; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0045920 negative regulation of exocytosis; GO:0045955 negative regulation of calcium ion-dependent exocytosis; GO:0046324 regulation of glucose import; GO:0046325 negative regulation of glucose import; GO:0046879 hormone secretion; GO:0046903 secretion; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051259 protein complex oligomerization; GO:0051291 protein heterooligomerization; GO:0051716 cellular response to stimulus; GO:0060322 head development; GO:0060627 regulation of vesicle-mediated transport; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070527 platelet aggregation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0098609 cell-cell adhesion; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1901652 response to peptide; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1903305 regulation of regulated secretory pathway; GO:1903306 negative regulation of regulated secretory pathway; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0030139 endocytic vesicle; GO:0030141 secretory granule; GO:0031091 platelet alpha granule; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0045177 apical part of cell; GO:0045335 phagocytic vesicle; GO:0070820 tertiary granule; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0099503 secretory vesicle;","GO:0000149 SNARE binding; GO:0005488 binding; GO:0005515 protein binding; GO:0017075 syntaxin-1 binding; GO:0019905 syntaxin binding;",null,null,"U","KOG1300","Vesicle trafficking protein Sec1","WP481 INSULIN SIGNALING","http://www.wikipathways.org/instance/WP481_r120562",null,"R-HSA-109582 Hemostasis;R-HSA-114516 Disinhibition of SNARE formation;R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114516;https://reactome.org/PathwayBrowser/#/R-HSA-1445148;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005"]
["O00189","AP-4 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP4M1 PE=1 SV=2","AP4M1",0.489516994,0.001189633,"down",4689.66,4557.39,5267.87,2374.77,2059.46,2671.07,1.301465017,1.264757713,1.461928695,0.659041397,0.5715372,0.741269978,"nucleus","K12402","AP4M1; AP-4 complex subunit mu-1","hsa04142 Lysosome","GO:0006605 protein targeting; GO:0006622 protein targeting to lysosome; GO:0006623 protein targeting to vacuole; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006895 Golgi to endosome transport; GO:0006896 Golgi to vacuole transport; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0008104 protein localization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016192 vesicle-mediated transport; GO:0016482 cytosolic transport; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061462 protein localization to lysosome; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0072657 protein localization to membrane; GO:0072665 protein localization to vacuole; GO:0072666 establishment of protein localization to vacuole; GO:0090160 Golgi to lysosome transport; GO:1903361 protein localization to basolateral plasma membrane; GO:1990778 protein localization to cell periphery;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0030124 AP-4 adaptor complex; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031904 endosome lumen; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048475 coated membrane; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019904 protein domain specific binding;","PF01217","PF01217 Clathrin adaptor complex small chain","U","KOG0937","Adaptor complexes medium subunit family",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432720;https://reactome.org/PathwayBrowser/#/R-HSA-5653656"]
["O00192","Splicing regulator ARVCF OS=Homo sapiens OX=9606 GN=ARVCF PE=1 SV=1","ARVCF",1.487902746,0.003348723,"up",3181.64,2717.06,2664.4,4481.53,4030.79,4228.74,0.896061614,0.765219563,0.750388656,1.262156311,1.13521209,1.190961765,"nucleus",{"$nulls":3},"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0007043 cell-cell junction assembly; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008219 cell death; GO:0008544 epidermis development; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009913 epidermal cell differentiation; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010172 embryonic body morphogenesis; GO:0010564 regulation of cell cycle process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; GO:0016358 dendrite development; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030216 keratinocyte differentiation; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031424 keratinization; GO:0032465 regulation of cytokinesis; GO:0032467 positive regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034331 cell junction maintenance; GO:0034332 adherens junction organization; GO:0034334 adherens junction maintenance; GO:0035635 entry of bacterium into host cell; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0043588 skin development; GO:0043954 cellular component maintenance; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044403 biological process involved in symbiotic interaction; GO:0044409 entry into host; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045216 cell-cell junction organization; GO:0045787 positive regulation of cell cycle; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051302 regulation of cell division; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051701 biological process involved in interaction with host; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0060429 epithelium development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0060996 dendritic spine development; GO:0060997 dendritic spine morphogenesis; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070268 cornification; GO:0071840 cellular component organization or biogenesis; GO:0090068 positive regulation of cell cycle process; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090596 sensory organ morphogenesis; GO:0097061 dendritic spine organization; GO:0098609 cell-cell adhesion; GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules; GO:0099173 postsynapse organization; GO:0106027 neuron projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis;","GO:0000922 spindle pole; GO:0001533 cornified envelope; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0009898 cytoplasmic side of plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016342 catenin complex; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030054 cell junction; GO:0030057 desmosome; GO:0030496 midbody; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0043025 neuronal cell body; GO:0043204 perikaryon; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0048471 perinuclear region of cytoplasm; GO:0051233 spindle midzone; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0045296 cadherin binding; GO:0050839 cell adhesion molecule binding;",null,null,"TW","KOG1048","Neural adherens junction protein Plakophilin and related Armadillo repeat proteins","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4657_r120007"]
["O00194","Ras-related protein Rab-27B OS=Homo sapiens OX=9606 GN=RAB27B PE=1 SV=4","RAB27B",1.062651405,0.2794661,"nochange",52515.8,45233.2,52303.5,52289.3,52836.9,54327.3,1.018057162,0.876878639,1.013941571,1.013666294,1.02428192,1.053174413,"cytoplasm","K07886","RAB27B; Ras-related protein Rab-27B","hsa04972 Pancreatic secretion","GO:0002576 platelet degranulation; GO:0006810 transport; GO:0006887 exocytosis; GO:0006903 vesicle targeting; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0017157 regulation of exocytosis; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032400 melanosome localization; GO:0032401 establishment of melanosome localization; GO:0032402 melanosome transport; GO:0032482 Rab protein signal transduction; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033059 cellular pigmentation; GO:0035556 intracellular signal transduction; GO:0042176 regulation of protein catabolic process; GO:0043473 pigmentation; GO:0044057 regulation of system process; GO:0044062 regulation of excretion; GO:0044085 cellular component biogenesis; GO:0045055 regulated exocytosis; GO:0045732 positive regulation of protein catabolic process; GO:0045921 positive regulation of exocytosis; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051875 pigment granule localization; GO:0051904 pigment granule transport; GO:0051905 establishment of pigment granule localization; GO:0060255 regulation of macromolecule metabolic process; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0071985 multivesicular body sorting pathway; GO:0080090 regulation of primary metabolic process; GO:0090522 vesicle tethering involved in exocytosis; GO:0097734 extracellular exosome biogenesis; GO:0099022 vesicle tethering; GO:0140029 exocytic process; GO:0140112 extracellular vesicle biogenesis; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1990182 exosomal secretion; GO:1990504 dense core granule exocytosis; GO:2000292 regulation of defecation; GO:2000294 positive regulation of defecation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005770 late endosome; GO:0005771 multivesicular body; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005798 Golgi-associated vesicle; GO:0005886 plasma membrane; GO:0008021 synaptic vesicle; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030140 trans-Golgi network transport vesicle; GO:0030141 secretory granule; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0030672 synaptic vesicle membrane; GO:0031088 platelet dense granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031225 anchored component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032585 multivesicular body membrane; GO:0042470 melanosome; GO:0042588 zymogen granule; GO:0042589 zymogen granule membrane; GO:0042827 platelet dense granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045177 apical part of cell; GO:0045202 synapse; GO:0048770 pigment granule; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098563 intrinsic component of synaptic vesicle membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098993 anchored component of synaptic vesicle membrane; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005525 GTP binding; GO:0008092 cytoskeletal protein binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017022 myosin binding; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0019003 GDP binding; GO:0019904 protein domain specific binding; GO:0031489 myosin V binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00071","PF00071 Ras family","U","KOG0081","GTPase Rab27"," small G protein superfamily","WP2291 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER","http://www.wikipathways.org/instance/WP2291_r117696",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-8873719 RAB geranylgeranylation;R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs;R-HSA-9007101 Rab regulation of trafficking","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005;https://reactome.org/PathwayBrowser/#/R-HSA-8873719;https://reactome.org/PathwayBrowser/#/R-HSA-8876198;https://reactome.org/PathwayBrowser/#/R-HSA-9007101"]
["O00203","AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3","AP3B1",1.147826725,0.003715698,"up",46666.7,44455.6,46621.4,53803.1,53254.8,51048,0.946427509,0.90158513,0.945508799,1.091157805,1.080037965,1.035282792,"cytoplasm","K12397","AP3B; AP-3 complex subunit beta","hsa04142 Lysosome","GO:0000041 transition metal ion transport; GO:0002376 immune system process; GO:0002475 antigen processing and presentation via MHC class Ib; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006605 protein targeting; GO:0006622 protein targeting to lysosome; GO:0006623 protein targeting to vacuole; GO:0006725 cellular aromatic compound metabolic process; GO:0006726 eye pigment biosynthetic process; GO:0006727 ommochrome biosynthetic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006829 zinc ion transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007033 vacuole organization; GO:0007034 vacuolar transport; GO:0007040 lysosome organization; GO:0007041 lysosomal transport; GO:0007220 Notch receptor processing; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008055 ocellus pigment biosynthetic process; GO:0008088 axo-dendritic transport; GO:0008089 anterograde axonal transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009058 biosynthetic process; GO:0009611 response to wounding; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010883 regulation of lipid storage; GO:0010970 transport along microtubule; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019748 secondary metabolic process; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0030001 metal ion transport; GO:0030155 regulation of cell adhesion; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031323 regulation of cellular metabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032438 melanosome organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033059 cellular pigmentation; GO:0033060 ocellus pigmentation; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042060 wound healing; GO:0042440 pigment metabolic process; GO:0042441 eye pigment metabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043324 pigment metabolic process involved in developmental pigmentation; GO:0043473 pigmentation; GO:0043474 pigment metabolic process involved in pigmentation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044550 secondary metabolite biosynthetic process; GO:0045184 establishment of protein localization; GO:0045580 regulation of T cell differentiation; GO:0045582 positive regulation of T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045621 positive regulation of lymphocyte differentiation; GO:0045785 positive regulation of cell adhesion; GO:0046148 pigment biosynthetic process; GO:0046152 ommochrome metabolic process; GO:0046158 ocellus pigment metabolic process; GO:0046483 heterocycle metabolic process; GO:0046634 regulation of alpha-beta T cell activation; GO:0046635 positive regulation of alpha-beta T cell activation; GO:0046637 regulation of alpha-beta T cell differentiation; GO:0046638 positive regulation of alpha-beta T cell differentiation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0047496 vesicle transport along microtubule; GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib; GO:0048007 antigen processing and presentation"," exogenous lipid antigen via MHC class Ib; GO:0048066 developmental pigmentation; GO:0048069 eye pigmentation; GO:0048193 Golgi vesicle transport; GO:0048489 synaptic vesicle transport; GO:0048490 anterograde synaptic vesicle transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048753 pigment granule organization; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051136 regulation of NK T cell differentiation; GO:0051138 positive regulation of NK T cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0060255 regulation of macromolecule metabolic process; GO:0060966 regulation of gene silencing by RNA; GO:0060967 negative regulation of gene silencing by RNA; GO:0061462 protein localization to lysosome; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072384 organelle transport along microtubule; GO:0072594 establishment of protein localization to organelle; GO:0072665 protein localization to vacuole; GO:0072666 establishment of protein localization to vacuole; GO:0080090 regulation of primary metabolic process; GO:0080171 lytic vacuole organization; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098657 import into cell; GO:0098930 axonal transport; GO:0099003 vesicle-mediated transport in synapse; GO:0099111 microtubule-based transport; GO:0099514 synaptic vesicle cytoskeletal transport; GO:0099517 synaptic vesicle transport along microtubule; GO:0099518 vesicle cytoskeletal trafficking; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1905952 regulation of lipid localization; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005802 trans-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0030123 AP-3 adaptor complex; GO:0030135 coated vesicle; GO:0030137 COPI-coated vesicle; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048475 coated membrane; GO:0097708 intracellular vesicle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex;","GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0030742 GTP-dependent protein binding;",null,null,"U","KOG1060","Vesicle coat complex AP-3"," beta subunit",{"$nulls":3},"R-HSA-1643685 Disease;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-6802952 Signaling by BRAF and RAF1 fusions;R-HSA-6802957 Oncogenic MAPK signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-6802952;https://reactome.org/PathwayBrowser/#/R-HSA-6802957","PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O00214","Galectin-8 OS=Homo sapiens OX=9606 GN=LGALS8 PE=1 SV=4","LGALS8",0.891054634,0.089275767,"nochange",13484.9,13659.5,11856.8,11806.3,11900.4,11045.5,1.097026035,1.111230126,0.964576548,0.960468263,0.968123503,0.898575523,"cytoplasm","K06832",null,null,"GO:0001667 ameboidal-type cell migration; GO:0001775 cell activation; GO:0001944 vasculature development; GO:0001945 lymph vessel development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002285 lymphocyte activation involved in immune response; GO:0002312 B cell activation involved in immune response; GO:0002313 mature B cell differentiation involved in immune response; GO:0002317 plasma cell differentiation; GO:0002335 mature B cell differentiation; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006914 autophagy; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008039 synaptic target recognition; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0016236 macroautophagy; GO:0016477 cell migration; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030182 neuron differentiation; GO:0030183 B cell differentiation; GO:0031294 lymphocyte costimulation; GO:0031295 T cell costimulation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0036303 lymph vessel morphogenesis; GO:0040011 locomotion; GO:0042113 B cell activation; GO:0043207 response to external biotic stimulus; GO:0043542 endothelial cell migration; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0045321 leukocyte activation; GO:0045785 positive regulation of cell adhesion; GO:0046649 lymphocyte activation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0061912 selective autophagy; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0072359 circulatory system development; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0098542 defense response to other organism; GO:0098586 cellular response to virus; GO:0098792 xenophagy; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1904977 lymphatic endothelial cell migration;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016936 galactoside binding; GO:0030246 carbohydrate binding; GO:0044877 protein-containing complex binding; GO:0050839 cell adhesion molecule binding; GO:0097367 carbohydrate derivative binding;","PF00337","PF00337 Galactoside-binding lectin","W","KOG3587","Galectin"," galactose-binding lectin"]
["O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8"," mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS8 PE=1 SV=1","NDUFS8",1.137658,0.024067121,"nochange",80656.1,83116.5,90950.7,96133.9,95675.5,97978.6,0.888754007,0.915865291,1.002190772,1.059304738,1.054253603,1.079631589,"mitochondria","K03941","NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0005759 mitochondrial matrix; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045271 respiratory chain complex I; GO:0070013 intracellular organelle lumen; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0050136 NADH dehydrogenase (quinone) activity;","PF12838","PF12838 4Fe-4S dicluster domain","C","KOG3256","NADH:ubiquinone oxidoreductase"," NDUFS8/23 kDa subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O00221","NF-kappa-B inhibitor epsilon OS=Homo sapiens OX=9606 GN=NFKBIE PE=1 SV=3","NFKBIE",0.725889162,0.000969896,"down",8773.8,7805.11,7929.57,5956.5,5899.02,5934.92,1.244542414,1.107136069,1.12479042,0.844915189,0.83676179,0.841854118,"nucleus","K05872","NFKBIE; NF-kappa-B inhibitor epsilon","hsa04662 B cell receptor signaling pathway; hsa04658 Th1 and Th2 cell differentiation; hsa05169 Epstein-Barr virus infection; hsa04659 Th17 cell differentiation; hsa04722 Neurotrophin signaling pathway; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04920 Adipocytokine signaling pathway; hsa04660 T cell receptor signaling pathway","GO:0006355 regulation of transcription"," DNA-templated; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006820 anion transport; GO:0006865 amino acid transport; GO:0008104 protein localization; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0015711 organic anion transport; GO:0015804 neutral amino acid transport; GO:0015849 organic acid transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032329 serine transport; GO:0033036 macromolecule localization; GO:0042221 response to chemical; GO:0042940 D-amino acid transport; GO:0042942 D-serine transport; GO:0042994 cytoplasmic sequestering of transcription factor; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0044092 negative regulation of molecular function; GO:0045185 maintenance of protein location; GO:0046942 carboxylic acid transport; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051220 cytoplasmic sequestering of protein; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen;",{"$nulls":3},"R","KOG0504","FOG: Ankyrin repeat","WP254 APOPTOSIS;WP4562 CANONICAL NFKB PATHWAY;WP4754 IL18 SIGNALING PATHWAY;WP3941 OXIDATIVE DAMAGE RESPONSE;WP4961 STING PATHWAY IN KAWASAKILIKE DISEASE AND COVID19;WP231 TNFALPHA SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP254_r118382;http://www.wikipathways.org/instance/WP4562_r117956;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP3941_r117040;http://www.wikipathways.org/instance/WP4961_r120610;http://www.wikipathways.org/instance/WP231_r120699",null,"R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-983705 Signaling by the B Cell Receptor (BCR)","https://reactome.org/PathwayBrowser/#/R-HSA-1168372;https://reactome.org/PathwayBrowser/#/R-HSA-1169091;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-983705","TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["O00231","26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3","PSMD11",1.121287154,0.025289261,"nochange",61783.3,59887.3,66853.9,71136.8,70404.9,69848.4,0.926947403,0.89850133,1.003022645,1.067279864,1.05629902,1.047949737,"cytoplasm","K03036","PSMD11; 26S proteasome regulatory subunit N6","hsa05017 Spinocerebellar ataxia; hsa05016 Huntington disease; hsa03050 Proteasome; hsa05169 Epstein-Barr virus infection; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010498 proteasomal protein catabolic process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016579 protein deubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043248 proteasome assembly; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048856 anatomical structure development; GO:0048863 stem cell differentiation; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0065003 protein-containing complex assembly; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000502 proteasome complex; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005838 proteasome regulatory particle; GO:0008541 proteasome regulatory particle"," lid subcomplex; GO:0012505 endomembrane system; GO:0022624 proteasome accessory complex; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1902494 catalytic complex; GO:1904813 ficolin-1-rich granule lumen; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;","GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding;","PF18055; PF01399; PF18503","PF18055 26S proteasome regulatory subunit RPN6 N-terminal domain; PF01399 PCI domain; PF18503 26S proteasome subunit RPN6 C-terminal helix domain","O","KOG1463","26S proteasome regulatory complex"," subunit RPN6/PSMD11","WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY;WP183 PROTEASOME DEGRADATION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2359_r119918;http://www.wikipathways.org/instance/WP183_r117060;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)"]
["O00232","26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3","PSMD12",1.034640471,0.044169104,"nochange",95707.8,94147.2,96982.9,100363,97620,98791.1,0.983953037,0.967908816,0.997062089,1.031812231,1.003611989,1.015651837,"cytoplasm","K03035","PSMD12; 26S proteasome regulatory subunit N5","hsa05017 Spinocerebellar ataxia; hsa05016 Huntington disease; hsa03050 Proteasome; hsa05169 Epstein-Barr virus infection; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0016192 vesicle-mediated transport; GO:0016579 protein deubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0032940 secretion by cell; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000502 proteasome complex; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005838 proteasome regulatory particle; GO:0008541 proteasome regulatory particle"," lid subcomplex; GO:0012505 endomembrane system; GO:0022624 proteasome accessory complex; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031595 nuclear proteasome complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1902494 catalytic complex; GO:1904813 ficolin-1-rich granule lumen; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;",null,"PF01399; PF18098","PF01399 PCI domain; PF18098 26S proteasome regulatory subunit RPN5 C-terminal domain","O","KOG1498","26S proteasome regulatory complex"," subunit RPN5/PSMD12","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP4352 CILIARY LANDSCAPE;WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY;WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP2359_r119918;http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["O00233","26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3","PSMD9",0.850785809,0.040760715,"nochange",46384.8,51755.3,53340.8,40217.3,43717.9,44942.6,0.992688295,1.107623198,1.14155473,0.860696672,0.935613555,0.96182355,"cytoskeleton","K06693","PSMD9; 26S proteasome regulatory subunit N4","hsa05017 Spinocerebellar ataxia; hsa05016 Huntington disease; hsa03050 Proteasome; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease","GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016579 protein deubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032024 positive regulation of insulin secretion; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043248 proteasome assembly; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046676 negative regulation of insulin secretion; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0046888 negative regulation of hormone secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070682 proteasome regulatory particle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:0090278 negative regulation of peptide hormone secretion; GO:0097050 type B pancreatic cell apoptotic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904019 epithelial cell apoptotic process; GO:1904950 negative regulation of establishment of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000502 proteasome complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005838 proteasome regulatory particle; GO:0008540 proteasome regulatory particle"," base subcomplex; GO:0022624 proteasome accessory complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008134 transcription factor binding; GO:0043425 bHLH transcription factor binding; GO:0140110 transcription regulator activity;","PF18265; PF17820","PF18265 Nas2 N_terminal domain; PF17820 PDZ domain","O","KOG3129","26S proteasome regulatory complex"," subunit PSMD9","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY;WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP2359_r119918;http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O00244","Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1","ATOX1",0.80842176,0.004792184,"down",12846.9,13573.9,13461.6,10900.7,10066.9,11274.2,1.068731438,1.129210445,1.119868227,0.906827389,0.837463708,0.937898791,"extracellular","K07213","ATOX1; copper chaperone","hsa04978 Mineral absorption","GO:0000041 transition metal ion transport; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006825 copper ion transport; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006878 cellular copper ion homeostasis; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0009987 cellular process; GO:0015680 protein maturation by copper ion transfer; GO:0019725 cellular homeostasis; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0042592 homeostatic process; GO:0046907 intracellular transport; GO:0046916 cellular transition metal ion homeostasis; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055065 metal ion homeostasis; GO:0055070 copper ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0098771 inorganic ion homeostasis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0005488 binding; GO:0005507 copper ion binding; GO:0005515 protein binding; GO:0016530 metallochaperone activity; GO:0016531 copper chaperone activity; GO:0032767 copper-dependent protein binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0140104 molecular carrier activity;","PF00403","PF00403 Heavy-metal-associated domain","P","KOG1603","Copper chaperone","WP3286 COPPER HOMEOSTASIS","http://www.wikipathways.org/instance/WP3286_r106367",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-2262752 Cellular responses to stress;R-HSA-3299685 Detoxification of Reactive Oxygen Species;R-HSA-6803157 Antimicrobial peptides;R-HSA-6803544 Ion influx/efflux at host-pathogen interface;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3299685;https://reactome.org/PathwayBrowser/#/R-HSA-6803157;https://reactome.org/PathwayBrowser/#/R-HSA-6803544;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9711123","COMPLEMENT;REACTIVE OXYGEN SPECIES PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"]
["O00255","Menin OS=Homo sapiens OX=9606 GN=MEN1 PE=1 SV=4","MEN1",1.061529244,0.303729829,"nochange",10152.3,8864.58,9540.76,10555.4,9471.37,10288,1.034674816,0.903436431,0.972349527,1.075756878,0.965277623,1.048504724,"mitochondria","K14970","MEN1; menin","hsa04934 Cushing syndrome; hsa05202 Transcriptional misregulation in cancer","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000165 MAPK cascade; GO:0000278 mitotic cell cycle; GO:0001501 skeletal system development; GO:0001503 ossification; GO:0001649 osteoblast differentiation; GO:0001666 response to hypoxia; GO:0001678 cellular glucose homeostasis; GO:0001776 leukocyte homeostasis; GO:0001890 placenta development; GO:0001893 maternal placenta development; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002051 osteoblast fate commitment; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002067 glandular epithelial cell differentiation; GO:0002076 osteoblast development; GO:0002165 instar larval or pupal development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003006 developmental process involved in reproduction; GO:0003309 type B pancreatic cell differentiation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006289 nucleotide-excision repair; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006479 protein methylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006970 response to osmotic stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007444 imaginal disc development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007565 female pregnancy; GO:0007568 aging; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008285 negative regulation of cell population proliferation; GO:0008340 determination of adult lifespan; GO:0009266 response to temperature stimulus; GO:0009314 response to radiation; GO:0009408 response to heat; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009651 response to salt stress; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010332 response to gamma radiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010810 regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0018022 peptidyl-lysine methylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030162 regulation of proteolysis; GO:0030278 regulation of ossification; GO:0030279 negative regulation of ossification; GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway; GO:0030855 epithelial cell differentiation; GO:0031016 pancreas development; GO:0031018 endocrine pancreas development; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031062 positive regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0032092 positive regulation of protein binding; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032925 regulation of activin receptor signaling pathway; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0033673 negative regulation of kinase activity; GO:0034284 response to monosaccharide; GO:0034641 cellular nitrogen compound metabolic process; GO:0034968 histone lysine methylation; GO:0035213 clypeo-labral disc development; GO:0035239 tube morphogenesis; GO:0035270 endocrine system development; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0035883 enteroendocrine cell differentiation; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036297 interstrand cross-link repair; GO:0040008 regulation of growth; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043393 regulation of protein binding; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043434 response to peptide hormone; GO:0043549 regulation of kinase activity; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045667 regulation of osteoblast differentiation; GO:0045668 negative regulation of osteoblast differentiation; GO:0045669 positive regulation of osteoblast differentiation; GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045778 positive regulation of ossification; GO:0045786 negative regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046483 heterocycle metabolic process; GO:0046528 imaginal disc fusion; GO:0046529 imaginal disc fusion"," thorax closure; GO:0046620 regulation of organ growth; GO:0046621 negative regulation of organ growth; GO:0046697 decidualization; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048562 embryonic organ morphogenesis; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048568 embryonic organ development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048704 embryonic skeletal system morphogenesis; GO:0048705 skeletal system morphogenesis; GO:0048706 embryonic skeletal system development; GO:0048707 instar larval or pupal morphogenesis; GO:0048728 proboscis development; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048872 homeostasis of number of cells; GO:0048878 chemical homeostasis; GO:0050678 regulation of epithelial cell proliferation; GO:0050680 negative regulation of epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051302 regulation of cell division; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051348 negative regulation of transferase activity; GO:0051568 histone H3-K4 methylation; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0051972 regulation of telomerase activity; GO:0051974 negative regulation of telomerase activity; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0055082 cellular chemical homeostasis; GO:0060021 roof of mouth development; GO:0060135 maternal process involved in female pregnancy; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061458 reproductive system development; GO:0061469 regulation of type B pancreatic cell proliferation; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070482 response to oxygen levels; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071326 cellular response to monosaccharide stimulus; GO:0071331 cellular response to hexose stimulus; GO:0071333 cellular response to glucose stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904030 negative regulation of cyclin-dependent protein kinase activity; GO:1904837 beta-catenin-TCF complex assembly; GO:1905269 positive regulation of chromatin organization; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2000278 regulation of DNA biosynthetic process; GO:2000279 negative regulation of DNA biosynthetic process; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000781 chromosome"," telomeric region; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016363 nuclear matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032153 cell division site; GO:0032154 cleavage furrow; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044665 MLL1/2 complex; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0000403 Y-form DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0030674 protein-macromolecule adaptor activity; GO:0043565 sequence-specific DNA binding; GO:0046332 SMAD binding; GO:0047485 protein N-terminus binding; GO:0060090 molecular adaptor activity; GO:0070412 R-SMAD binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",{"$nulls":7},"Transcription factor","R-HSA-162582 Signal Transduction;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex;R-HSA-212436 Generic Transcription Pathway;R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer;R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;R-HSA-3769402 Deactivation of the beta-catenin transactivating complex;R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);R-HSA-392499 Metabolism of proteins;R-HSA-5626467 RHO GTPases activate IQGAPs;R-HSA-597592 Post-translational protein modification;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8957275 Post-translational protein phosphorylation;R-HSA-9006936 Signaling by TGFB family members;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-170834;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-201681;https://reactome.org/PathwayBrowser/#/R-HSA-201722;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2173793;https://reactome.org/PathwayBrowser/#/R-HSA-2173796;https://reactome.org/PathwayBrowser/#/R-HSA-3769402;https://reactome.org/PathwayBrowser/#/R-HSA-381426;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5626467;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8957275;https://reactome.org/PathwayBrowser/#/R-HSA-9006936;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O00257","E3 SUMO-protein ligase CBX4 OS=Homo sapiens OX=9606 GN=CBX4 PE=1 SV=3","CBX4",0.444217952,0.015067584,"nochange",14472.5,14543.1,16102.5,6530.07,4448.11,9064.09,1.332635158,1.339136042,1.482726387,0.601292166,0.40958423,0.834626016,"nucleus","K11452",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0016925 protein sumoylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032446 protein modification by small protein conjugation; GO:0036211 protein modification process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0000152 nuclear ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0016604 nuclear body; GO:0031519 PcG protein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035102 PRC1 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019789 SUMO transferase activity; GO:0019899 enzyme binding; GO:0032182 ubiquitin-like protein binding; GO:0032183 SUMO binding; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0051219 phosphoprotein binding; GO:0097159 organic cyclic compound binding; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00385","PF00385 Chromo (CHRromatin Organisation MOdifier) domain","B","KOG2748","Uncharacterized conserved protein"," contains chromo domain",{"$nulls":3},"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559583 Cellular Senescence;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3899300 SUMOylation of transcription cofactors;R-HSA-392499 Metabolism of proteins;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-4570464 SUMOylation of RNA binding proteins;R-HSA-4655427 SUMOylation of DNA methylation proteins;R-HSA-597592 Post-translational protein modification;R-HSA-6807070 PTEN Regulation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;R-HSA-8943724 Regulation of PTEN gene transcription;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2559580;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108214;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-3899300;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4551638;https://reactome.org/PathwayBrowser/#/R-HSA-4570464;https://reactome.org/PathwayBrowser/#/R-HSA-4655427;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8939243;https://reactome.org/PathwayBrowser/#/R-HSA-8943724;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9006925"]
["O00258","Guided entry of tail-anchored proteins factor 1 OS=Homo sapiens OX=9606 GN=GET1 PE=1 SV=2","GET1",0.957621449,0.298441222,"nochange",3335.05,3374.62,3394.97,3050.47,3168.86,3457.09,1.011588863,1.023591253,1.029763825,0.92526993,0.961180038,1.048606091,"plasma membrane","K22384",null,null,"GO:0000003 reproduction; GO:0001654 eye development; GO:0003006 developmental process involved in reproduction; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007423 sensory organ development; GO:0007507 heart development; GO:0008104 protein localization; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010996 response to auditory stimulus; GO:0016043 cellular component organization; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0043010 camera-type eye development; GO:0044703 multi-organism reproductive process; GO:0045048 protein insertion into ER membrane; GO:0045184 establishment of protein localization; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051205 protein insertion into membrane; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0060041 retina development in camera-type eye; GO:0061024 membrane organization; GO:0070727 cellular macromolecule localization; GO:0071816 tail-anchored membrane protein insertion into ER membrane; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"R","KOG4253","Tryptophan-rich basic nuclear protein",{"$nulls":3},"R-HSA-9609507 Protein localization;R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","https://reactome.org/PathwayBrowser/#/R-HSA-9609507;https://reactome.org/PathwayBrowser/#/R-HSA-9609523"]
["O00264","Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3","PGRMC1",1.198533076,3.362402E-3,"up",74729.9,75660,71121.3,88493.9,91867.9,85126.7,0.920697487,0.932156632,0.876238322,1.090274594,1.131843408,1.048789558,"nucleus","K17278","PGRMC1_2; membrane-associated progesterone receptor component","hsa04080 Neuroactive ligand-receptor interaction","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001556 oocyte maturation; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006955 immune response; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007613 memory; GO:0008306 associative learning; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0036230 granulocyte activation; GO:0040011 locomotion; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050808 synapse organization; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051321 meiotic cell cycle; GO:0060341 regulation of cellular localization; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071695 anatomical structure maturation; GO:0071840 cellular component organization or biogenesis; GO:0097485 neuron projection guidance; GO:0099563 modification of synaptic structure; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1903046 meiotic cell cycle process; GO:1903076 regulation of protein localization to plasma membrane; GO:1903078 positive regulation of protein localization to plasma membrane; GO:1903537 meiotic cell cycle process involved in oocyte maturation; GO:1903829 positive regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904377 positive regulation of protein localization to cell periphery; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:1905809 negative regulation of synapse organization;","GO:0000775 chromosome"," centromeric region; GO:0001674 female germ cell nucleus; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005783 endoplasmic reticulum; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0014069 postsynaptic density; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030424 axon; GO:0030496 midbody; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0035579 specific granule membrane; GO:0036477 somatodendritic compartment; GO:0042581 specific granule; GO:0042585 germinal vesicle; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043073 germ cell nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0045202 synapse; GO:0051233 spindle midzone; GO:0070062 extracellular exosome; GO:0071944 cell periphery; GO:0072687 meiotic spindle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098687 chromosomal region; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099503 secretory vesicle; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection; GO:1903561 extracellular vesicle; GO:1990385 meiotic spindle midzone;","GO:0005488 binding; GO:0005496 steroid binding; GO:0008289 lipid binding; GO:0020037 heme binding; GO:0032934 sterol binding; GO:0035100 ecdysone binding; GO:0036094 small molecule binding; GO:0042562 hormone binding; GO:0043178 alcohol binding; GO:0046906 tetrapyrrole binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00173","PF00173 Cytochrome b5-like Heme/Steroid binding domain","R","KOG1110","Putative steroid membrane receptor Hpr6.6/25-Dx",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695","XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["O00267","Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1","SUPT5H",1.282791576,1.00355E-4,"up",55737.7,53046.5,54699.1,69537.5,70881.6,69295.9,0.896108584,0.852841505,0.879410758,1.117971331,1.139580754,1.114087068,"nucleus","K15172","SUPT5H; transcription elongation factor SPT5","hsa03250 Viral life cycle - HIV-1","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001764 neuron migration; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001961 positive regulation of cytokine-mediated signaling pathway; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007549 dosage compensation; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009452 7-methylguanosine RNA capping; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016477 cell migration; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0021953 central nervous system neuron differentiation; GO:0021954 central nervous system neuron development; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031440 regulation of mRNA 3'-end processing; GO:0031441 negative regulation of mRNA 3'-end processing; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032784 regulation of DNA-templated transcription"," elongation; GO:0032785 negative regulation of DNA-templated transcription"," elongation; GO:0032786 positive regulation of DNA-templated transcription"," elongation; GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter; GO:0034243 regulation of transcription elongation from RNA polymerase II promoter; GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036260 RNA capping; GO:0040011 locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0040036 regulation of fibroblast growth factor receptor signaling pathway; GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050684 regulation of mRNA processing; GO:0050686 negative regulation of mRNA processing; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051674 localization of cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060330 regulation of response to interferon-gamma; GO:0060332 positive regulation of response to interferon-gamma; GO:0060334 regulation of interferon-gamma-mediated signaling pathway; GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway; GO:0060759 regulation of response to cytokine stimulus; GO:0060760 positive regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090288 negative regulation of cellular response to growth factor stimulus; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1900363 regulation of mRNA polyadenylation; GO:1900364 negative regulation of mRNA polyadenylation; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901532 regulation of hematopoietic progenitor cell differentiation; GO:1901534 positive regulation of hematopoietic progenitor cell differentiation; GO:1901576 organic substance biosynthetic process; GO:1902036 regulation of hematopoietic stem cell differentiation; GO:1902038 positive regulation of hematopoietic stem cell differentiation; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1904892 regulation of receptor signaling pathway via STAT; GO:1904894 positive regulation of receptor signaling pathway via STAT; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000736 regulation of stem cell differentiation; GO:2000738 positive regulation of stem cell differentiation; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005705 polytene chromosome interband; GO:0008023 transcription elongation factor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032044 DSIF complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF11942","PF11942 Spt5 transcription elongation factor"," acidic N-terminal","K","KOG1999","RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5","WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR;WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP3414_r106735;http://www.wikipathways.org/instance/WP411_r117160","Transcription factor","R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-113418 Formation of the Early Elongation Complex;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167158 Formation of the HIV-1 Early Elongation Complex;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation;R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat;R-HSA-167243 Tat-mediated HIV elongation arrest and recovery;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-167287 HIV elongation arrest and recovery;R-HSA-167290 Pausing and recovery of HIV elongation;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5663205 Infectious disease;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6807505 RNA polymerase II transcribes snRNA genes;R-HSA-72086 mRNA Capping;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-112382;https://reactome.org/PathwayBrowser/#/R-HSA-113418;https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-167152;https://reactome.org/PathwayBrowser/#/R-HSA-167158;https://reactome.org/PathwayBrowser/#/R-HSA-167160;https://reactome.org/PathwayBrowser/#/R-HSA-167169;https://reactome.org/PathwayBrowser/#/R-HSA-167172;https://reactome.org/PathwayBrowser/#/R-HSA-167200;https://reactome.org/PathwayBrowser/#/R-HSA-167238;https://reactome.org/PathwayBrowser/#/R-HSA-167242;https://reactome.org/PathwayBrowser/#/R-HSA-167243;https://reactome.org/PathwayBrowser/#/R-HSA-167246;https://reactome.org/PathwayBrowser/#/R-HSA-167287;https://reactome.org/PathwayBrowser/#/R-HSA-167290;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-674695;https://reactome.org/PathwayBrowser/#/R-HSA-6796648;https://reactome.org/PathwayBrowser/#/R-HSA-6807505;https://reactome.org/PathwayBrowser/#/R-HSA-72086;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75955;https://reactome.org/PathwayBrowser/#/R-HSA-77075;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O00268","Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2","TAF4",0.910503288,0.219084789,"nochange",10407.2,10146.7,9091.77,8142.49,9606.02,9243.97,1.102493637,1.074897397,0.963142687,0.862580081,1.017620102,0.979266095,"nucleus","K03129","TAF4; transcription initiation factor TFIID subunit 4","hsa03022 Basal transcription factors; hsa05016 Huntington disease","GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009794 regulation of mitotic cell cycle"," embryonic; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023051 regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045995 regulation of embryonic development; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1902531 regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000123 histone acetyltransferase complex; GO:0000228 nuclear chromosome; GO:0000428 DNA-directed RNA polymerase complex; GO:0000785 chromatin; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005669 transcription factor TFIID complex; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031248 protein acetyltransferase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033276 transcription factor TFTC complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044665 MLL1/2 complex; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0070461 SAGA-type complex; GO:0071339 MLL1 complex; GO:0090575 RNA polymerase II transcription regulator complex; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0017162 aryl hydrocarbon receptor binding; GO:0051059 NF-kappaB binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG2341","TATA box binding protein (TBP)-associated factor"," RNA polymerase II",null,null,"Transcription factor","R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167161 HIV Transcription Initiation;R-HSA-167162 RNA Polymerase II HIV Promoter Escape;R-HSA-167172 Transcription of the HIV genome;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5663205 Infectious disease;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-73776 RNA Polymerase II Promoter Escape;R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75953 RNA Polymerase II Transcription Initiation;R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-167161;https://reactome.org/PathwayBrowser/#/R-HSA-167162;https://reactome.org/PathwayBrowser/#/R-HSA-167172;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5633007;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-674695;https://reactome.org/PathwayBrowser/#/R-HSA-6804756;https://reactome.org/PathwayBrowser/#/R-HSA-73776;https://reactome.org/PathwayBrowser/#/R-HSA-73779;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75953;https://reactome.org/PathwayBrowser/#/R-HSA-76042"]
["O00273","DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1","DFFA",0.655624207,0.023838333,"nochange",17047.3,15961.9,17454.8,8595.52,12706.8,11783.1,1.22423112,1.146284439,1.253495237,0.617276817,0.91252339,0.846188998,"nucleus","K02310","DFFA; DNA fragmentation factor"," 45 kD"," alpha subunit","hsa04210 Apoptosis","GO:0000737 DNA catabolic process"," endonucleolytic; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006308 DNA catabolic process; GO:0006309 apoptotic DNA fragmentation; GO:0006457 protein folding; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006921 cellular component disassembly involved in execution phase of apoptosis; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0022411 cellular component disassembly; GO:0030262 apoptotic nuclear changes; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032069 regulation of nuclease activity; GO:0032070 regulation of deoxyribonuclease activity; GO:0032074 negative regulation of nuclease activity; GO:0032076 negative regulation of deoxyribonuclease activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061077 chaperone-mediated protein folding; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070227 lymphocyte apoptotic process; GO:0070231 T cell apoptotic process; GO:0070242 thymocyte apoptotic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071887 leukocyte apoptotic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0097194 execution phase of apoptosis; GO:1900117 regulation of execution phase of apoptosis; GO:1900118 negative regulation of execution phase of apoptosis; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902510 regulation of apoptotic DNA fragmentation; GO:1902511 negative regulation of apoptotic DNA fragmentation; GO:1903624 regulation of DNA catabolic process; GO:1903625 negative regulation of DNA catabolic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0044183 protein folding chaperone; GO:0060703 deoxyribonuclease inhibitor activity; GO:0098772 molecular function regulator;","PF02017; PF09033","PF02017 CIDE-N domain; PF09033 DNA Fragmentation factor 45kDa"," C terminal domain",{"$nulls":3},"WP4298 ACUTE VIRAL MYOCARDITIS;WP254 APOPTOSIS;WP1772 APOPTOSIS MODULATION AND SIGNALING;WP314 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS","http://www.wikipathways.org/instance/WP4298_r120527;http://www.wikipathways.org/instance/WP254_r118382;http://www.wikipathways.org/instance/WP1772_r120736;http://www.wikipathways.org/instance/WP314_r116694",null,"R-HSA-109581 Apoptosis;R-HSA-140342 Apoptosis induced DNA fragmentation;R-HSA-5357801 Programmed Cell Death;R-HSA-75153 Apoptotic execution phase","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-140342;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-75153","APOPTOSIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APOPTOSIS"]
["O00287","Regulatory factor X-associated protein OS=Homo sapiens OX=9606 GN=RFXAP PE=1 SV=1","RFXAP",0.969505501,0.748292397,"nochange",3397.37,3366.88,2745.99,2822.79,3142.63,3254.81,1.088291965,1.078524992,0.879633026,0.904234651,1.006690168,1.042625198,"nucleus","K08063","RFXAP; regulatory factor X-associated protein","hsa05152 Tuberculosis; hsa04612 Antigen processing and presentation; hsa05340 Primary immunodeficiency","GO:0006355 regulation of transcription"," DNA-templated; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF15289","PF15289 Regulatory factor X-associated C-terminal binding domain",{"$nulls":5},"Transcription factor"]
["O00291","Huntingtin-interacting protein 1 OS=Homo sapiens OX=9606 GN=HIP1 PE=1 SV=5","HIP1",0.917559139,0.794472112,"nochange",1263.21,747.659,714.333,831.535,828.541,840.458,1.450371775,0.858434869,0.820171168,0.954738242,0.95130064,0.964983306,"nucleus","K04559","HIP1; huntingtin interacting protein 1","hsa05016 Huntington disease; hsa05022 Pathways of neurodegeneration - multiple diseases","GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006915 apoptotic process; GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008219 cell death; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway; GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030100 regulation of endocytosis; GO:0030162 regulation of proteolysis; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030837 negative regulation of actin filament polymerization; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031503 protein-containing complex localization; GO:0031647 regulation of protein stability; GO:0032092 positive regulation of protein binding; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032535 regulation of cellular component size; GO:0032594 protein transport within lipid bilayer; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034613 cellular protein localization; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043254 regulation of protein-containing complex assembly; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043393 regulation of protein binding; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045184 establishment of protein localization; GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway; GO:0045807 positive regulation of endocytosis; GO:0045862 positive regulation of proteolysis; GO:0046902 regulation of mitochondrial membrane permeability; GO:0046907 intracellular transport; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048268 clathrin coat assembly; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051668 localization within membrane; GO:0051716 cellular response to stimulus; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090559 regulation of membrane permeability; GO:0097190 apoptotic signaling pathway; GO:0098657 import into cell; GO:0099632 protein transport within plasma membrane; GO:0099637 neurotransmitter receptor transport; GO:0110053 regulation of actin filament organization; GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; GO:1901184 regulation of ERBB signaling pathway; GO:1901186 positive regulation of ERBB signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000369 regulation of clathrin-dependent endocytosis; GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway; GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030425 dendrite; GO:0030659 cytoplasmic vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030665 clathrin-coated vesicle membrane; GO:0031090 organelle membrane; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0032587 ruffle membrane; GO:0032838 plasma membrane bounded cell projection cytoplasm; GO:0032839 dendrite cytoplasm; GO:0036477 somatodendritic compartment; GO:0042734 presynaptic membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0044309 neuron spine; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0098888 extrinsic component of presynaptic membrane; GO:0098890 extrinsic component of postsynaptic membrane; GO:0098984 neuron to neuron synapse; GO:0099243 extrinsic component of synaptic membrane; GO:0099568 cytoplasmic region; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection; GO:0120111 neuron projection cytoplasm;","GO:0003779 actin binding; GO:0005102 signaling receptor binding; GO:0005154 epidermal growth factor receptor binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0030276 clathrin binding; GO:0030674 protein-macromolecule adaptor activity; GO:0032051 clathrin light chain binding; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0035254 glutamate receptor binding; GO:0035612 AP-2 adaptor complex binding; GO:0035615 clathrin adaptor activity; GO:0038024 cargo receptor activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043325 phosphatidylinositol-3","4-bisphosphate binding; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0051015 actin filament binding; GO:0060090 molecular adaptor activity; GO:0070851 growth factor receptor binding; GO:0080025 phosphatidylinositol-3","5-bisphosphate binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF07651","PF07651 ANTH domain","Z","KOG0980","Actin-binding protein SLA2/Huntingtin-interacting protein Hip1",{"$nulls":3},"R-HSA-1643685 Disease;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9700206 Signaling by ALK in cancer;R-HSA-9700645 ALK mutants bind TKIs;R-HSA-9725370 Signaling by ALK fusions and activated point mutants","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9700206;https://reactome.org/PathwayBrowser/#/R-HSA-9700645;https://reactome.org/PathwayBrowser/#/R-HSA-9725370"]
["O00299","Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4","CLIC1",1.222585734,0.000528848,"up",203738,213078,208260,248157,254698,261354,0.879897213,0.920234509,0.899426684,1.071732582,1.099981645,1.128727367,"cytoplasm","K05021",null,null,"GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006821 chloride transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009987 cellular process; GO:0015698 inorganic anion transport; GO:0023052 signaling; GO:0030278 regulation of ossification; GO:0034220 ion transmembrane transport; GO:0042391 regulation of membrane potential; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045667 regulation of osteoblast differentiation; GO:0045669 positive regulation of osteoblast differentiation; GO:0045778 positive regulation of ossification; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051716 cellular response to stimulus; GO:0051881 regulation of mitochondrial membrane potential; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0098656 anion transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098661 inorganic anion transmembrane transport; GO:1902476 chloride transmembrane transport;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005903 brush border; GO:0012505 endomembrane system; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0070062 extracellular exosome; GO:0098862 cluster of actin-based cell projections; GO:1903561 extracellular vesicle;","GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005244 voltage-gated ion channel activity; GO:0005247 voltage-gated chloride channel activity; GO:0005253 anion channel activity; GO:0005254 chloride channel activity; GO:0008308 voltage-gated anion channel activity; GO:0008509 anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015108 chloride transmembrane transporter activity; GO:0015267 channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022803 passive transmembrane transporter activity; GO:0022832 voltage-gated channel activity; GO:0022836 gated channel activity; GO:0022839 ion gated channel activity; GO:0022857 transmembrane transporter activity;","PF13409; PF13410","PF13409 Glutathione S-transferase"," N-terminal domain; PF13410 Glutathione S-transferase"," C-terminal domain","P","KOG1422","Intracellular Cl- channel CLIC"," contains GST domain","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782"]
["O00303","Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1","EIF3F",0.915856372,0.028914898,"nochange",75396.1,76183,78512,66980.7,71854.7,71895,1.026212651,1.036923108,1.068623014,0.911671051,0.978010828,0.978559349,"mitochondria","K03249",null,null,"GO:0006412 translation; GO:0006413 translational initiation; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008593 regulation of Notch signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016032 viral process; GO:0016579 protein deubiquitination; GO:0019080 viral gene expression; GO:0019081 viral translation; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045747 positive regulation of Notch signaling pathway; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0075522 IRES-dependent viral translational initiation; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005852 eukaryotic translation initiation factor 3 complex; GO:0032991 protein-containing complex; GO:0071541 eukaryotic translation initiation factor 3 complex"," eIF3m;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003743 translation initiation factor activity; GO:0003824 catalytic activity; GO:0004843 thiol-dependent deubiquitinase; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0016787 hydrolase activity; GO:0019783 ubiquitin-like protein-specific protease activity; GO:0031369 translation initiation factor binding; GO:0097159 organic cyclic compound binding; GO:0101005 deubiquitinase activity; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG2975","Translation initiation factor 3"," subunit f (eIF-3f)","WP5027 NSP1 FROM SARSCOV2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL;WP107 TRANSLATION FACTORS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5027_r120060;http://www.wikipathways.org/instance/WP107_r117851;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-392499 Metabolism of proteins;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72649 Translation initiation complex formation;R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72695 Formation of the ternary complex"," and subsequently"," the 43S complex;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-156827;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72649;https://reactome.org/PathwayBrowser/#/R-HSA-72662;https://reactome.org/PathwayBrowser/#/R-HSA-72689;https://reactome.org/PathwayBrowser/#/R-HSA-72695;https://reactome.org/PathwayBrowser/#/R-HSA-72702;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2","WWP2",1.226942336,0.211271301,"nochange",2515.18,3432.93,3665.83,4496.75,3392,3907,0.704871486,0.96206811,1.027337621,1.260200405,0.950597603,1.094924775,"mitochondria","K05630","WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [EC:2.3.2.26]","hsa04120 Ubiquitin mediated proteolysis","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000209 protein polyubiquitination; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006858 extracellular transport; GO:0008152 metabolic process; GO:0008593 regulation of Notch signaling pathway; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010959 regulation of metal ion transport; GO:0016032 viral process; GO:0016070 RNA metabolic process; GO:0016567 protein ubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019058 viral life cycle; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032409 regulation of transporter activity; GO:0032410 negative regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032446 protein modification by small protein conjugation; GO:0032774 RNA biosynthetic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0036211 protein modification process; GO:0042391 regulation of membrane potential; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043266 regulation of potassium ion transport; GO:0043269 regulation of ion transport; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044409 entry into host; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045746 negative regulation of Notch signaling pathway; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046718 viral entry into host cell; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051701 biological process involved in interaction with host; GO:0051865 protein autoubiquitination; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070534 protein K63-linked ubiquitination; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901016 regulation of potassium ion transmembrane transporter activity; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901379 regulation of potassium ion transmembrane transport; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904062 regulation of cation transmembrane transport; GO:1904950 negative regulation of establishment of protein localization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity;","PF00397; PF00632","PF00397 WW domain; PF00632 HECT-domain (ubiquitin-transferase)","O","KOG0940","Ubiquitin protein ligase RSP5/NEDD4",{"$nulls":3},"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-6807070 PTEN Regulation;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9012852 Signaling by NOTCH3;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013409 RHOJ GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-157118;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-8948751;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9012852;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013409;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-9013507;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O00311","Cell division cycle 7-related protein kinase OS=Homo sapiens OX=9606 GN=CDC7 PE=1 SV=1","CDC7",1.062152266,0.767433262,"nochange",6844.93,6398.01,7523.64,7797.61,5562.52,8697.14,0.959035211,0.896417767,1.054128482,1.092514101,0.779358231,1.218546207,"cytoplasm","K02214","CDC7; cell division control protein 7 [EC:2.7.11.1]","hsa04110 Cell cycle","GO:0000003 reproduction; GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000727 double-strand break repair via break-induced replication; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006270 DNA replication initiation; GO:0006275 regulation of DNA replication; GO:0006277 DNA amplification; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006325 chromatin organization; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007113 endomitotic cell cycle; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007307 eggshell chorion gene amplification; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008360 regulation of cell shape; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010571 positive regulation of nuclear cell cycle DNA replication; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010948 negative regulation of cell cycle process; GO:0010971 positive regulation of G2/M transition of mitotic cell cycle; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016570 histone modification; GO:0016572 histone phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0033262 regulation of nuclear cell cycle DNA replication; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0042127 regulation of cell population proliferation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045740 positive regulation of DNA replication; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070316 regulation of G0 to G1 transition; GO:0070317 negative regulation of G0 to G1 transition; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0090329 regulation of DNA-dependent DNA replication; GO:0098657 import into cell; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902751 positive regulation of cell cycle G2/M phase transition; GO:1903047 mitotic cell cycle process; GO:2000105 positive regulation of DNA-dependent DNA replication; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031431 Dbf4-dependent protein kinase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045171 intercellular bridge; GO:0070013 intracellular organelle lumen; GO:0072686 mitotic spindle;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0035173 histone kinase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00069","PF00069 Protein kinase domain","L","KOG1167","Serine/threonine protein kinase of the CDC7 subfamily involved in DNA synthesis"," repair and recombination","WP179 CELL CYCLE;WP466 DNA REPLICATION;WP2446 RETINOBLASTOMA GENE IN CANCER","http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP466_r117096;http://www.wikipathways.org/instance/WP2446_r116593",null,"R-HSA-1640170 Cell Cycle;R-HSA-176187 Activation of ATR in response to replication stress;R-HSA-212436 Generic Transcription Pathway;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-68962 Activation of the pre-replicative complex;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69206 G1/S Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953750 Transcriptional Regulation by E2F6","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-176187;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-453279;https://reactome.org/PathwayBrowser/#/R-HSA-68962;https://reactome.org/PathwayBrowser/#/R-HSA-69002;https://reactome.org/PathwayBrowser/#/R-HSA-69206;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69306;https://reactome.org/PathwayBrowser/#/R-HSA-69481;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953750","G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O00330","Pyruvate dehydrogenase protein X component"," mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3","PDHX",1.133117574,0.053091691,"nochange",26239.8,25385.1,25930.6,26953.1,31384.6,29541.8,0.951665609,0.920667332,0.940451537,0.977535588,1.138257322,1.071422613,"mitochondria","K13997","PDHX; dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex","hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006084 acetyl-CoA metabolic process; GO:0006085 acetyl-CoA biosynthetic process; GO:0006086 acetyl-CoA biosynthetic process from pyruvate; GO:0006090 pyruvate metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0018130 heterocycle biosynthetic process; GO:0019362 pyridine nucleotide metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035383 thioester metabolic process; GO:0035384 thioester biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate; GO:0071616 acyl-CoA biosynthetic process; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072524 pyridine-containing compound metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045254 pyruvate dehydrogenase complex; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;",null,"PF00364","PF00364 Biotin-requiring enzyme","C","KOG0557","Dihydrolipoamide acetyltransferase","WP3925 AMINO ACID METABOLISM;WP4236 KREBS CYCLE DISORDERS","http://www.wikipathways.org/instance/WP3925_r117062;http://www.wikipathways.org/instance/WP4236_r120410",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-162582 Signal Transduction;R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex;R-HSA-389661 Glyoxylate metabolism and glycine degradation;R-HSA-5362517 Signaling by Retinoic Acid;R-HSA-70268 Pyruvate metabolism;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle;R-HSA-9006931 Signaling by Nuclear Receptors","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-204174;https://reactome.org/PathwayBrowser/#/R-HSA-389661;https://reactome.org/PathwayBrowser/#/R-HSA-5362517;https://reactome.org/PathwayBrowser/#/R-HSA-70268;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-71406;https://reactome.org/PathwayBrowser/#/R-HSA-9006931","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O00400","Acetyl-coenzyme A transporter 1 OS=Homo sapiens OX=9606 GN=SLC33A1 PE=1 SV=1","SLC33A1",0.74953169,0.121025201,"nochange",11813.8,9683.24,9016.96,6282.18,6956.96,9632.07,1.327761003,1.088305918,1.013422257,0.706058476,0.781897458,1.082554887,"plasma membrane","K03372","SLC33A1; MFS transporter"," PAT family"," solute carrier family 33 (acetyl-CoA transportor)"," member 1 [EC:2.3.1.-]","hsa00604 Glycosphingolipid biosynthesis - ganglio series; hsa01100 Metabolic pathways","GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006820 anion transport; GO:0006862 nucleotide transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015865 purine nucleotide transport; GO:0015868 purine ribonucleotide transport; GO:0015876 acetyl-CoA transport; GO:0015916 fatty-acyl-CoA transport; GO:0015931 nucleobase-containing compound transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0030509 BMP signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034220 ion transmembrane transport; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051503 adenine nucleotide transport; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0060255 regulation of macromolecule metabolic process; GO:0060395 SMAD protein signal transduction; GO:0065007 biological regulation; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071106 adenosine 3'","5'-bisphosphate transmembrane transport; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071772 response to BMP; GO:0071773 cellular response to BMP stimulus; GO:0072348 sulfur compound transport; GO:0072530 purine-containing compound transmembrane transport; GO:0080090 regulation of primary metabolic process; GO:0098655 cation transmembrane transport; GO:0098656 anion transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:1901264 carbohydrate derivative transport; GO:1901337 thioester transport; GO:1901679 nucleotide transmembrane transport; GO:1902600 proton transmembrane transport; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000295 adenine nucleotide transmembrane transporter activity; GO:0005215 transporter activity; GO:0005346 purine ribonucleotide transmembrane transporter activity; GO:0008324 cation transmembrane transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0008521 acetyl-CoA transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015078 proton transmembrane transporter activity; GO:0015215 nucleotide transmembrane transporter activity; GO:0015216 purine nucleotide transmembrane transporter activity; GO:0015291 secondary active transmembrane transporter activity; GO:0015293 symporter activity; GO:0015294 solute:cation symporter activity; GO:0015295 solute:proton symporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015605 organophosphate ester transmembrane transporter activity; GO:0015932 nucleobase-containing compound transmembrane transporter activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0042887 amide transmembrane transporter activity; GO:0071077 adenosine 3'","5'-bisphosphate transmembrane transporter activity; GO:1901505 carbohydrate derivative transmembrane transporter activity; GO:1901682 sulfur compound transmembrane transporter activity;",null,null,"P","KOG3574","Acetyl-CoA transporter","WP1423 GANGLIO SPHINGOLIPID METABOLISM","http://www.wikipathways.org/instance/WP1423_r117518",null,"R-HSA-1643685 Disease;R-HSA-382551 Transport of small molecules;R-HSA-425397 Transport of vitamins"," nucleosides"," and related molecules;R-HSA-425407 SLC-mediated transmembrane transport;R-HSA-5619061 Defective SLC33A1 causes spastic paraplegia 42 (SPG42);R-HSA-5619102 SLC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-425397;https://reactome.org/PathwayBrowser/#/R-HSA-425407;https://reactome.org/PathwayBrowser/#/R-HSA-5619061;https://reactome.org/PathwayBrowser/#/R-HSA-5619102;https://reactome.org/PathwayBrowser/#/R-HSA-5619115"]
["O00409","Forkhead box protein N3 OS=Homo sapiens OX=9606 GN=FOXN3 PE=1 SV=1","FOXN3",0.927330559,0.847754194,"nochange",1809.9,"NA",1139.07,1137.32,"NA",1597.35,1.273761181,"NA",0.80164824,0.800416634,"NA",1.124173945,"nucleus","K09407",null,null,"GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0001501 skeletal system development; GO:0001666 response to hypoxia; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007095 mitotic G2 DNA damage checkpoint signaling; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007507 heart development; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0035050 embryonic heart tube development; GO:0035295 tube development; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044818 mitotic G2/M transition checkpoint; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045786 negative regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048568 embryonic organ development; GO:0048705 skeletal system morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051302 regulation of cell division; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060348 bone development; GO:0060349 bone morphogenesis; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0070887 cellular response to chemical stimulus; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0097094 craniofacial suture morphogenesis; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904888 cranial skeletal system development; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000976 transcription cis-regulatory region binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00250","PF00250 Forkhead domain","K","KOG2294","Transcription factor of the Forkhead/HNF3 family","WP2853 ENDODERM DIFFERENTIATION;WP4754 IL18 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2853_r116557;http://www.wikipathways.org/instance/WP4754_r115147","Transcription factor",null,null,"G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O00410","Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4","IPO5",1.003418465,0.863735645,"nochange",160659,166219,168081,165899,169062,161690,0.972110003,1.005752261,1.017018788,1.003816016,1.022954589,0.978348343,"cytoplasm","K20222","IPO5; importin-5","hsa03013 Nucleocytoplasmic transport","GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0001101 response to acid chemical; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006610 ribosomal protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0009719 response to endogenous stimulus; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0017038 protein import; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033365 protein localization to organelle; GO:0033673 negative regulation of kinase activity; GO:0034260 negative regulation of GTPase activity; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042886 amide transport; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043200 response to amino acid; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0045184 establishment of protein localization; GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045786 negative regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051348 negative regulation of transferase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071230 cellular response to amino acid stimulus; GO:0071310 cellular response to organic substance; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090316 positive regulation of intracellular protein transport; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903829 positive regulation of protein localization; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904030 negative regulation of cyclin-dependent protein kinase activity; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904951 positive regulation of establishment of protein localization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0004857 enzyme inhibitor activity; GO:0005048 signal sequence binding; GO:0005095 GTPase inhibitor activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008139 nuclear localization sequence binding; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;",null,null,"YU","KOG2171","Karyopherin (importin) beta 3",{"$nulls":3},"R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-192905 vRNP Assembly;R-HSA-5663205 Infectious disease","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168273;https://reactome.org/PathwayBrowser/#/R-HSA-192905;https://reactome.org/PathwayBrowser/#/R-HSA-5663205"]
["O00411","DNA-directed RNA polymerase"," mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2","POLRMT",0.979504017,0.393963863,"nochange",16447.1,16807.8,17242.8,16438,16027.7,16997,0.987216938,1.008867512,1.034977851,0.986670722,0.962042969,1.020224009,"nucleus","K10908",null,null,"GO:0000959 mitochondrial RNA metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006390 mitochondrial transcription; GO:0006391 transcription initiation from mitochondrial promoter; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0140053 mitochondrial gene expression; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0009295 nucleoid; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0034245 mitochondrial DNA-directed RNA polymerase complex; GO:0042645 mitochondrial nucleoid; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003824 catalytic activity; GO:0003899 DNA-directed 5'-3' RNA polymerase activity; GO:0005488 binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0034062 5'-3' RNA polymerase activity; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0097747 RNA polymerase activity; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF14700","PF14700 DNA-directed RNA polymerase N-terminal","KL","KOG1038","Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41"," provides primers for DNA replication-initiation","WP391 MITOCHONDRIAL GENE EXPRESSION","http://www.wikipathways.org/instance/WP391_r117794",null,"R-HSA-1592230 Mitochondrial biogenesis;R-HSA-163282 Mitochondrial transcription initiation;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis;R-HSA-74160 Gene expression (Transcription);R-HSA-75944 Transcription from mitochondrial promoters","https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-163282;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-2151201;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75944"]
["O00418","Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2","EEF2K",0.328314126,{"v":4.05045e-05,"d":"4.05E-05"},"down",10205.9,10309.4,8703.79,3102.64,3232.5,3257.9,1.577738712,1.593738865,1.345526257,0.479639741,0.499714909,0.503641516,"cytoplasm","nucleus","K08292","EEF2K; elongation factor 2 kinase [EC:2.7.11.20]","hsa04921 Oxytocin signaling pathway; hsa04152 AMPK signaling pathway","GO:0001932 regulation of protein phosphorylation; GO:0002931 response to ischemia; GO:0006412 translation; GO:0006414 translational elongation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006518 peptide metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010243 response to organonitrogen compound; GO:0010467 gene expression; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016310 phosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031952 regulation of protein autophosphorylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0033554 cellular response to stress; GO:0034059 response to anoxia; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043043 peptide biosynthetic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045807 positive regulation of endocytosis; GO:0046683 response to organophosphorus; GO:0046777 protein autophosphorylation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051591 response to cAMP; GO:0051592 response to calcium ion; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0060998 regulation of dendritic spine development; GO:0060999 positive regulation of dendritic spine development; GO:0061001 regulation of dendritic spine morphogenesis; GO:0061003 positive regulation of dendritic spine morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070482 response to oxygen levels; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071277 cellular response to calcium ion; GO:0071310 cellular response to organic substance; GO:0071320 cellular response to cAMP; GO:0071363 cellular response to growth factor stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071453 cellular response to oxygen levels; GO:0071454 cellular response to anoxia; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0099175 regulation of postsynapse organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1990089 response to nerve growth factor; GO:1990090 cellular response to nerve growth factor stimulus; GO:1990416 cellular response to brain-derived neurotrophic factor stimulus; GO:1990637 response to prolactin; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0014069 postsynaptic density; GO:0030425 dendrite; GO:0032279 asymmetric synapse; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0044309 neuron spine; GO:0045202 synapse; GO:0097447 dendritic tree; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004683 calmodulin-dependent protein kinase activity; GO:0004686 elongation factor-2 kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0008135 translation factor activity"," RNA binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;",{"$nulls":5},"WP1403 AMPACTIVATED PROTEIN KINASE AMPK SIGNALING;WP3676 BDNFTRKB SIGNALING;WP107 TRANSLATION FACTORS","http://www.wikipathways.org/instance/WP1403_r116516;http://www.wikipathways.org/instance/WP3676_r116809;http://www.wikipathways.org/instance/WP107_r117851",null,"R-HSA-162582 Signal Transduction;R-HSA-165159 MTOR signalling;R-HSA-166208 mTORC1-mediated signalling","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-165159;https://reactome.org/PathwayBrowser/#/R-HSA-166208"]
["O00421","C-C chemokine receptor-like 2 OS=Homo sapiens OX=9606 GN=CCRL2 PE=1 SV=2","CCRL2",2.100717106,0.019885755,"nochange",3822.65,2270.59,4302.71,6526.23,7190.69,8122.03,0.711523845,0.422633233,0.800879171,1.214751093,1.338429466,1.511783192,"plasma membrane","K08373",null,null,"GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0009605 response to external stimulus; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0019221 cytokine-mediated signaling pathway; GO:0023052 signaling; GO:0034097 response to cytokine; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070098 chemokine-mediated signaling pathway; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus;","GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0071944 cell periphery;","GO:0001637 G protein-coupled chemoattractant receptor activity; GO:0001653 peptide receptor activity; GO:0001664 G protein-coupled receptor binding; GO:0004888 transmembrane signaling receptor activity; GO:0004896 cytokine receptor activity; GO:0004930 G protein-coupled receptor activity; GO:0004950 chemokine receptor activity; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008528 G protein-coupled peptide receptor activity; GO:0016493 C-C chemokine receptor activity; GO:0038023 signaling receptor activity; GO:0042379 chemokine receptor binding; GO:0048020 CCR chemokine receptor binding; GO:0060089 molecular transducer activity;",null,null,"R","KOG3656","FOG: 7 transmembrane receptor","WP455 GPCRS CLASS A RHODOPSINLIKE;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP455_r117740;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-162582 Signal Transduction;R-HSA-372790 Signaling by GPCR;R-HSA-373076 Class A/1 (Rhodopsin-like receptors);R-HSA-375276 Peptide ligand-binding receptors;R-HSA-380108 Chemokine receptors bind chemokines;R-HSA-500792 GPCR ligand binding","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-373076;https://reactome.org/PathwayBrowser/#/R-HSA-375276;https://reactome.org/PathwayBrowser/#/R-HSA-380108;https://reactome.org/PathwayBrowser/#/R-HSA-500792","INFLAMMATORY RESPONSE;INTERFERON ALPHA RESPONSE;TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["O00422","Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1","SAP18",1.562821958,0.000467648,"up",50168.9,48805.2,51763.8,83576.8,73072.4,78927.3,0.779192803,0.758012645,0.803963818,1.29806396,1.134916017,1.225850758,"nucleus","K14324","SAP18; histone deacetylase complex subunit SAP18","hsa03013 Nucleocytoplasmic transport; hsa03015 mRNA surveillance pathway","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006476 protein deacetylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016570 histone modification; GO:0016575 histone deacetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0033119 negative regulation of RNA splicing; GO:0034641 cellular nitrogen compound metabolic process; GO:0035601 protein deacylation; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048025 negative regulation of mRNA splicing"," via spliceosome; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050684 regulation of mRNA processing; GO:0050686 negative regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0098732 macromolecule deacylation; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000118 histone deacetylase complex; GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016580 Sin3 complex; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0061574 ASAP complex; GO:0070013 intracellular organelle lumen; GO:0070822 Sin3-type complex; GO:1902494 catalytic complex;","GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0004407 histone deacetylase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016811 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in linear amides; GO:0019213 deacetylase activity; GO:0033558 protein deacetylase activity; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity;",null,null,"K","KOG3391","Transcriptional co-repressor component","WP47 HEDGEHOG SIGNALING PATHWAY WP47","http://www.wikipathways.org/instance/WP47_r120579",null,"R-HSA-1643685 Disease;R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-3214815 HDACs deacetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-4839726 Chromatin organization;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-5663205 Infectious disease;R-HSA-74160 Gene expression (Transcription);R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-3214815;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-427413;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5250941;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-9679191;https://reactome.org/PathwayBrowser/#/R-HSA-9679506"]
["O00425","Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2","IGF2BP3",0.62892447,0.000341821,"down",16333.6,17578.5,16814.5,11289,10005.5,10608.7,1.186032158,1.276428117,1.220951763,0.819728476,0.726529654,0.770329833,"cytoplasm","K13197",null,null,"GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0001817 regulation of cytokine production; GO:0005975 carbohydrate metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006412 translation; GO:0006417 regulation of translation; GO:0006518 peptide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007528 neuromuscular junction development; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016322 neuron remodeling; GO:0017148 negative regulation of translation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031667 response to nutrient levels; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0040007 growth; GO:0042551 neuron maturation; GO:0042594 response to starvation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT; GO:0046483 heterocycle metabolic process; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048679 regulation of axon regeneration; GO:0048680 positive regulation of axon regeneration; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051124 synaptic assembly at neuromuscular junction; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0061013 regulation of mRNA catabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070570 regulation of neuron projection regeneration; GO:0070572 positive regulation of neuron projection regeneration; GO:0071695 anatomical structure maturation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903311 regulation of mRNA metabolic process; GO:1904892 regulation of receptor signaling pathway via STAT; GO:1904894 positive regulation of receptor signaling pathway via STAT; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030424 axon; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body; GO:0120025 plasma membrane bounded cell projection;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019955 cytokine binding; GO:0045182 translation regulator activity; GO:0048027 mRNA 5'-UTR binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00076; PF00013","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain); PF00013 KH domain","AR","KOG2193","IGF-II mRNA-binding protein IMP"," contains RRM and KH domains",{"$nulls":3},"R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-428359;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O00429","Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2","DNM1L",1.243097585,0.000256651,"up",118203,112555,116222,145811,140835,144684,0.911228174,0.867687682,0.895956624,1.124058537,1.085698501,1.115370482,"cytoplasm","K17065","DNM1L; dynamin 1-like protein [EC:3.6.5.5]","hsa04621 NOD-like receptor signaling pathway; hsa04668 TNF signaling pathway; hsa04217 Necroptosis","GO:0000266 mitochondrial fission; GO:0000278 mitotic cell cycle; GO:0000281 mitotic cytokinesis; GO:0000910 cytokinesis; GO:0001505 regulation of neurotransmitter levels; GO:0001666 response to hypoxia; GO:0001703 gastrulation with mouth forming first; GO:0001836 release of cytochrome c from mitochondria; GO:0001956 positive regulation of neurotransmitter secretion; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003015 heart process; GO:0003373 dynamin family protein polymerization involved in membrane fission; GO:0003374 dynamin family protein polymerization involved in mitochondrial fission; GO:0006140 regulation of nucleotide metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006900 vesicle budding from membrane; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007031 peroxisome organization; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007370 ventral furrow formation; GO:0007399 nervous system development; GO:0008015 blood circulation; GO:0008104 protein localization; GO:0008219 cell death; GO:0008637 apoptotic mitochondrial changes; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010004 gastrulation involving germ band extension; GO:0010033 response to organic substance; GO:0010506 regulation of autophagy; GO:0010635 regulation of mitochondrial fusion; GO:0010637 negative regulation of mitochondrial fusion; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane; GO:0016192 vesicle-mediated transport; GO:0016559 peroxisome fission; GO:0017157 regulation of exocytosis; GO:0017158 regulation of calcium ion-dependent exocytosis; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030382 sperm mitochondrion organization; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032459 regulation of protein oligomerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0036465 synaptic vesicle recycling; GO:0036466 synaptic vesicle recycling via endosome; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043254 regulation of protein-containing complex assembly; GO:0043547 positive regulation of GTPase activity; GO:0043653 mitochondrial fragmentation involved in apoptotic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045807 positive regulation of endocytosis; GO:0045921 positive regulation of exocytosis; GO:0045956 positive regulation of calcium ion-dependent exocytosis; GO:0046907 intracellular transport; GO:0046928 regulation of neurotransmitter secretion; GO:0048285 organelle fission; GO:0048311 mitochondrion distribution; GO:0048312 intracellular distribution of mitochondria; GO:0048488 synaptic vesicle endocytosis; GO:0048489 synaptic vesicle transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051258 protein polymerization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051262 protein tetramerization; GO:0051289 protein homotetramerization; GO:0051301 cell division; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051588 regulation of neurotransmitter transport; GO:0051590 positive regulation of neurotransmitter transport; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060047 heart contraction; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0060998 regulation of dendritic spine development; GO:0060999 positive regulation of dendritic spine development; GO:0061001 regulation of dendritic spine morphogenesis; GO:0061003 positive regulation of dendritic spine morphogenesis; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0062012 regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070142 synaptic vesicle budding; GO:0070201 regulation of establishment of protein localization; GO:0070265 necrotic cell death; GO:0070266 necroptotic process; GO:0070482 response to oxygen levels; GO:0070584 mitochondrion morphogenesis; GO:0070585 protein localization to mitochondrion; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071453 cellular response to oxygen levels; GO:0071496 cellular response to external stimulus; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090140 regulation of mitochondrial fission; GO:0090141 positive regulation of mitochondrial fission; GO:0090148 membrane fission; GO:0090149 mitochondrial membrane fission; GO:0090199 regulation of release of cytochrome c from mitochondria; GO:0090200 positive regulation of release of cytochrome c from mitochondria; GO:0090649 response to oxygen-glucose deprivation; GO:0090650 cellular response to oxygen-glucose deprivation; GO:0097190 apoptotic signaling pathway; GO:0097194 execution phase of apoptosis; GO:0097300 programmed necrotic cell death; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098657 import into cell; GO:0098693 regulation of synaptic vesicle cycle; GO:0099003 vesicle-mediated transport in synapse; GO:0099175 regulation of postsynapse organization; GO:0099177 regulation of trans-synaptic signaling; GO:0099504 synaptic vesicle cycle; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1900063 regulation of peroxisome organization; GO:1900242 regulation of synaptic vesicle endocytosis; GO:1900244 positive regulation of synaptic vesicle endocytosis; GO:1900542 regulation of purine nucleotide metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902803 regulation of synaptic vesicle transport; GO:1902805 positive regulation of synaptic vesicle transport; GO:1903047 mitotic cell cycle process; GO:1903146 regulation of autophagy of mitochondrion; GO:1903305 regulation of regulated secretory pathway; GO:1903307 positive regulation of regulated secretory pathway; GO:1903421 regulation of synaptic vesicle recycling; GO:1903423 positive regulation of synaptic vesicle recycling; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903578 regulation of ATP metabolic process; GO:1904578 response to thapsigargin; GO:1904579 cellular response to thapsigargin; GO:1904951 positive regulation of establishment of protein localization; GO:1905395 response to flavonoid; GO:1990910 response to hypobaric hypoxia; GO:2000026 regulation of multicellular organismal development; GO:2000300 regulation of synaptic vesicle exocytosis; GO:2000302 positive regulation of synaptic vesicle exocytosis; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005777 peroxisome; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005903 brush border; GO:0005905 clathrin-coated pit; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0019867 outer membrane; GO:0030133 transport vesicle; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030672 synaptic vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098827 endoplasmic reticulum subcompartment; GO:0098862 cluster of actin-based cell projections; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005525 GTP binding; GO:0008017 microtubule binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0030276 clathrin binding; GO:0030695 GTPase regulator activity; GO:0030742 GTP-dependent protein binding; GO:0031267 small GTPase binding; GO:0031625 ubiquitin protein ligase binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0051400 BH domain binding; GO:0051433 BH2 domain binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0098772 molecular function regulator; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00350","PF00350 Dynamin family","UR","KOG0446","Vacuolar sorting protein VPS1"," dynamin"," and related proteins","WP4874 CAMKK2 PATHWAY;WP2267 SYNAPTIC VESICLE PATHWAY","http://www.wikipathways.org/instance/WP4874_r117669;http://www.wikipathways.org/instance/WP2267_r117179",null,"R-HSA-109581 Apoptosis;R-HSA-5357801 Programmed Cell Death;R-HSA-75153 Apoptotic execution phase","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-75153","APOPTOSIS;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APOPTOSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O00442","RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1","RTCA",0.805627274,0.032160186,"nochange",27650.6,32335.7,30878.3,23172.1,23210.7,26820.2,1.011190509,1.182525983,1.1292284399999999,0.847410458,0.848822071,0.980822539,"endoplasmic reticulum","mitochondria","K01974",null,null,"GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0009987 cellular process; GO:0010721 negative regulation of cell development; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048679 regulation of axon regeneration; GO:0048681 negative regulation of axon regeneration; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0070570 regulation of neuron projection regeneration; GO:0070571 negative regulation of neuron projection regeneration; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1903034 regulation of response to wounding; GO:1903035 negative regulation of response to wounding; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0003963 RNA-3'-phosphate cyclase activity; GO:0009975 cyclase activity; GO:0016874 ligase activity; GO:0016886 ligase activity"," forming phosphoric ester bonds; GO:0140098 catalytic activity"," acting on RNA;","PF01137; PF05189","PF01137 RNA 3'-terminal phosphate cyclase; PF05189 RNA 3'-terminal phosphate cyclase (RTC)"," insert domain","A","KOG3980","RNA 3'-terminal phosphate cyclase"]
["O00459","Phosphatidylinositol 3-kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PIK3R2 PE=1 SV=2","PIK3R2",0.759427282,0.204788956,"nochange",3394.43,2514.62,3806.37,2374.23,2544.54,"NA",1.159760123,0.85915927,1.30050587,0.81119283,0.869381906,"NA","nucleus","K02649","PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta","hsa04666 Fc gamma R-mediated phagocytosis; hsa05160 Hepatitis C; hsa04014 Ras signaling pathway; hsa04923 Regulation of lipolysis in adipocytes; hsa05224 Breast cancer; hsa01521 EGFR tyrosine kinase inhibitor resistance; hsa04360 Axon guidance; hsa05203 Viral carcinogenesis; hsa04919 Thyroid hormone signaling pathway; hsa04650 Natural killer cell mediated cytotoxicity; hsa05166 Human T-cell leukemia virus 1 infection; hsa05200 Pathways in cancer; hsa04211 Longevity regulating pathway; hsa04210 Apoptosis; hsa05205 Proteoglycans in cancer; hsa04370 VEGF signaling pathway; hsa05226 Gastric cancer; hsa05206 MicroRNAs in cancer; hsa04012 ErbB signaling pathway; hsa04914 Progesterone-mediated oocyte maturation; hsa04071 Sphingolipid signaling pathway; hsa04929 GnRH secretion; hsa04152 AMPK signaling pathway; hsa04072 Phospholipase D signaling pathway; hsa04932 Non-alcoholic fatty liver disease; hsa04662 B cell receptor signaling pathway; hsa05162 Measles; hsa05223 Non-small cell lung cancer; hsa04668 TNF signaling pathway; hsa04973 Carbohydrate digestion and absorption; hsa05222 Small cell lung cancer; hsa04066 HIF-1 signaling pathway; hsa04722 Neurotrophin signaling pathway; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa01524 Platinum drug resistance; hsa04218 Cellular senescence; hsa04930 Type II diabetes mellitus; hsa04611 Platelet activation; hsa05417 Lipid and atherosclerosis; hsa04933 AGE-RAGE signaling pathway in diabetic complications; hsa04380 Osteoclast differentiation; hsa04725 Cholinergic synapse; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05161 Hepatitis B; hsa05221 Acute myeloid leukemia; hsa05169 Epstein-Barr virus infection; hsa05207 Chemical carcinogenesis - receptor activation; hsa05418 Fluid shear stress and atherosclerosis; hsa05010 Alzheimer disease; hsa04917 Prolactin signaling pathway; hsa05165 Human papillomavirus infection; hsa05168 Herpes simplex virus 1 infection; hsa04670 Leukocyte transendothelial migration; hsa04625 C-type lectin receptor signaling pathway; hsa05135 Yersinia infection; hsa05171 Coronavirus disease - COVID-19; hsa05017 Spinocerebellar ataxia; hsa05164 Influenza A; hsa05212 Pancreatic cancer; hsa05163 Human cytomegalovirus infection; hsa04750 Inflammatory mediator regulation of TRP channels; hsa05220 Chronic myeloid leukemia; hsa04620 Toll-like receptor signaling pathway; hsa04960 Aldosterone-regulated sodium reabsorption; hsa05211 Renal cell carcinoma; hsa05415 Diabetic cardiomyopathy; hsa04935 Growth hormone synthesis"," secretion and action; hsa05225 Hepatocellular carcinoma; hsa04660 T cell receptor signaling pathway; hsa04915 Estrogen signaling pathway; hsa05214 Glioma; hsa04931 Insulin resistance; hsa05215 Prostate cancer; hsa04664 Fc epsilon RI signaling pathway; hsa05146 Amoebiasis; hsa04613 Neutrophil extracellular trap formation; hsa05100 Bacterial invasion of epithelial cells; hsa04910 Insulin signaling pathway; hsa04068 FoxO signaling pathway; hsa05020 Prion disease; hsa04510 Focal adhesion; hsa05170 Human immunodeficiency virus 1 infection; hsa05131 Shigellosis; hsa04070 Phosphatidylinositol signaling system; hsa05210 Colorectal cancer; hsa04015 Rap1 signaling pathway; hsa04630 JAK-STAT signaling pathway; hsa04213 Longevity regulating pathway - multiple species; hsa01522 Endocrine resistance; hsa04062 Chemokine signaling pathway; hsa04926 Relaxin signaling pathway; hsa04150 mTOR signaling pathway; hsa05142 Chagas disease; hsa04140 Autophagy - animal; hsa05213 Endometrial cancer; hsa05231 Choline metabolism in cancer; hsa04810 Regulation of actin cytoskeleton; hsa04024 cAMP signaling pathway; hsa04550 Signaling pathways regulating pluripotency of stem cells; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa04151 PI3K-Akt signaling pathway; hsa05218 Melanoma; hsa05230 Central carbon metabolism in cancer","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001678 cellular glucose homeostasis; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007568 aging; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008152 metabolic process; GO:0008286 insulin receptor signaling pathway; GO:0008340 determination of adult lifespan; GO:0008361 regulation of cell size; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010594 regulation of endothelial cell migration; GO:0010596 negative regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010633 negative regulation of epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010941 regulation of cell death; GO:0014065 phosphatidylinositol 3-kinase signaling; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0016525 negative regulation of angiogenesis; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019725 cellular homeostasis; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030168 platelet activation; GO:0030182 neuron differentiation; GO:0030258 lipid modification; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0031175 neuron projection development; GO:0031294 lymphocyte costimulation; GO:0031295 T cell costimulation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032231 regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033120 positive regulation of RNA splicing; GO:0033157 regulation of intracellular protein transport; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0034097 response to cytokine; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034976 response to endoplasmic reticulum stress; GO:0035556 intracellular signal transduction; GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038095 Fc-epsilon receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0038127 ERBB signaling pathway; GO:0038128 ERBB2 signaling pathway; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040024 dauer larval development; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043254 regulation of protein-containing complex assembly; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043434 response to peptide hormone; GO:0043484 regulation of RNA splicing; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0043537 negative regulation of blood vessel endothelial cell migration; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0043550 regulation of lipid kinase activity; GO:0043551 regulation of phosphatidylinositol 3-kinase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045765 regulation of angiogenesis; GO:0045785 positive regulation of cell adhesion; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046324 regulation of glucose import; GO:0046326 positive regulation of glucose import; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046834 lipid phosphorylation; GO:0046854 phosphatidylinositol phosphate biosynthetic process; GO:0048009 insulin-like growth factor receptor signaling pathway; GO:0048010 vascular endothelial growth factor receptor signaling pathway; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048878 chemical homeostasis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050821 protein stabilization; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0055082 cellular chemical homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060396 growth hormone receptor signaling pathway; GO:0060416 response to growth hormone; GO:0060548 negative regulation of cell death; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071378 cellular response to growth hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090049 regulation of cell migration involved in sprouting angiogenesis; GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090316 positive regulation of intracellular protein transport; GO:0090407 organophosphate biosynthetic process; GO:0097485 neuron projection guidance; GO:0098657 import into cell; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900078 positive regulation of cellular response to insulin stimulus; GO:1900101 regulation of endoplasmic reticulum unfolded protein response; GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903076 regulation of protein localization to plasma membrane; GO:1903078 positive regulation of protein localization to plasma membrane; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903670 regulation of sprouting angiogenesis; GO:1903671 negative regulation of sprouting angiogenesis; GO:1903725 regulation of phospholipid metabolic process; GO:1903829 positive regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904377 positive regulation of protein localization to cell periphery; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:1905897 regulation of response to endoplasmic reticulum stress; GO:1905898 positive regulation of response to endoplasmic reticulum stress; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0005942 phosphatidylinositol 3-kinase complex; GO:0005943 phosphatidylinositol 3-kinase complex"," class IA; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097651 phosphatidylinositol 3-kinase complex"," class I; GO:0098796 membrane protein complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0001784 phosphotyrosine residue binding; GO:0003824 catalytic activity; GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity; GO:0005096 GTPase activator activity; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005158 insulin receptor binding; GO:0005159 insulin-like growth factor receptor binding; GO:0005165 neurotrophin receptor binding; GO:0005167 neurotrophin TRK receptor binding; GO:0005168 neurotrophin TRKA receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008134 transcription factor binding; GO:0016301 kinase activity; GO:0016303 1-phosphatidylinositol-3-kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017046 peptide hormone binding; GO:0019207 kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0030234 enzyme regulator activity; GO:0030674 protein-macromolecule adaptor activity; GO:0030695 GTPase regulator activity; GO:0030971 receptor tyrosine kinase binding; GO:0033218 amide binding; GO:0035004 phosphatidylinositol 3-kinase activity; GO:0035014 phosphatidylinositol 3-kinase regulator activity; GO:0035591 signaling adaptor activity; GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding; GO:0042277 peptide binding; GO:0042562 hormone binding; GO:0043125 ErbB-3 class receptor binding; GO:0043548 phosphatidylinositol 3-kinase binding; GO:0043559 insulin binding; GO:0043560 insulin receptor substrate binding; GO:0044877 protein-containing complex binding; GO:0045309 protein phosphorylated amino acid binding; GO:0046934 phosphatidylinositol-4","5-bisphosphate 3-kinase activity; GO:0046935 1-phosphatidylinositol-3-kinase regulator activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0051219 phosphoprotein binding; GO:0052742 phosphatidylinositol kinase activity; GO:0052813 phosphatidylinositol bisphosphate kinase activity; GO:0060090 molecular adaptor activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator; GO:1990782 protein tyrosine kinase binding;","PF00620; PF00017; PF16454","PF00620 RhoGAP domain; PF00017 SH2 domain; PF16454 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain","T","KOG4637","Adaptor for phosphoinositide 3-kinase","WP244 ALPHA 6 BETA 4 SIGNALING PATHWAY;WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP1403 AMPACTIVATED PROTEIN KINASE AMPK SIGNALING;WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY;WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP2828 BLADDER CANCER;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP4262 BREAST CANCER PATHWAY;WP4582 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE;WP3929 CHEMOKINE SIGNALING PATHWAY;WP710 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT;WP4217 EBOLA VIRUS INFECTION IN HOST;WP437 EGFEGFR SIGNALING PATHWAY;WP4806 EGFR TYROSINE KINASE INHIBITOR RESISTANCE;WP3931 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS;WP4155 ENDOMETRIAL CANCER;WP4239 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER;WP673 ERBB SIGNALING PATHWAY;WP306 FOCAL ADHESION;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP524 G13 SIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP2261 GLIOBLASTOMA SIGNALING PATHWAYS;WP4674 HEAD AND NECK SQUAMOUS CELL CARCINOMA;WP4666 HEPATITIS B INFECTION;WP195 IL1 SIGNALING PATHWAY;WP286 IL3 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP127 IL5 SIGNALING PATHWAY;WP364 IL6 SIGNALING PATHWAY;WP205 IL7 SIGNALING PATHWAY;WP22 IL9 SIGNALING PATHWAY;WP481 INSULIN SIGNALING;WP185 INTEGRINMEDIATED CELL ADHESION;WP585 INTERFERON TYPE I SIGNALING PATHWAYS;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP2034 LEPTIN SIGNALING PATHWAY;WP4829 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION;WP4630 MEASLES VIRUS INFECTION;WP4685 MELANOMA;WP4205 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA;WP3937 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP4255 NONSMALL CELL LUNG CANCER;WP61 NOTCH SIGNALING PATHWAY;WP5094 OREXIN RECEPTOR PATHWAY;WP4787 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES;WP4263 PANCREATIC ADENOCARCINOMA PATHWAY;WP4172 PI3KAKT SIGNALING PATHWAY;WP3844 PI3KAKTMTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES;WP2037 PROLACTIN SIGNALING PATHWAY;WP2018 RANKLRANK SIGNALING PATHWAY;WP4223 RAS SIGNALING;WP51 REGULATION OF ACTIN CYTOSKELETON;WP4658 SMALL CELL LUNG CANCER;WP4539 SYNAPTIC SIGNALING PATHWAYS ASSOCIATED WITH AUTISM SPECTRUM DISORDER;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY;WP366 TGFBETA SIGNALING PATHWAY;WP2032 THYROID STIMULATING HORMONE TSH SIGNALING PATHWAY;WP75 TOLLLIKE RECEPTOR SIGNALING PATHWAY;WP4566 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY",null,null,"R-HSA-109582 Hemostasis;R-HSA-109704 PI3K Cascade;R-HSA-112399 IRS-mediated signalling;R-HSA-114604 GPVI-mediated activation cascade;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266695 Interleukin-7 signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-1433557 Signaling by SCF-KIT;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1500931 Cell-Cell communication;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-166520 Signaling by NTRKs;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-186763 Downstream signal transduction;R-HSA-186797 Signaling by PDGF;R-HSA-187037 Signaling by NTRK1 (TRKA);R-HSA-194138 Signaling by VEGF;R-HSA-194315 Signaling by Rho GTPases;R-HSA-198203 PI3K/AKT activation;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-201556 Signaling by ALK;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029485 Role of phospholipids in phagocytosis;R-HSA-210993 Tie2 Signaling;R-HSA-2172127 DAP12 interactions;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer;R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);R-HSA-2424491 DAP12 signaling;R-HSA-2428924 IGF1R signaling cascade;R-HSA-2428928 IRS-related events triggered by IGF1R;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization;R-HSA-372790 Signaling by GPCR;R-HSA-373753 Nephrin family interactions;R-HSA-388396 GPCR downstream signalling;R-HSA-388841 Costimulation by the CD28 family;R-HSA-389356 CD28 co-stimulation;R-HSA-389357 CD28 dependent PI3K/Akt signaling;R-HSA-416476 G alpha (q) signalling events;R-HSA-422475 Axon guidance;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-449147 Signaling by Interleukins;R-HSA-451927 Interleukin-2 family signaling;R-HSA-512988 Interleukin-3"," Interleukin-5 and GM-CSF signaling;R-HSA-556833 Metabolism of lipids;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-74751 Insulin receptor signalling cascade;R-HSA-74752 Signaling by Insulin receptor;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-8853659 RET signaling;R-HSA-8939211 ESR-mediated signaling;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9009391 Extra-nuclear estrogen signaling;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013405 RHOD GTPase cycle;R-HSA-9013409 RHOJ GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9035034 RHOF GTPase cycle;R-HSA-912526 Interleukin receptor SHC signaling;R-HSA-912631 Regulation of signaling by CBL;R-HSA-9669938 Signaling by KIT in disease;R-HSA-9670439 Signaling by phosphorylated juxtamembrane"," extracellular and kinase domain KIT mutants;R-HSA-9671555 Signaling by PDGFR in disease;R-HSA-9673767 Signaling by PDGFRA transmembrane"," juxtamembrane and kinase domain mutants;R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants;R-HSA-9675108 Nervous system development;R-HSA-9696264 RND3 GTPase cycle;R-HSA-9696270 RND2 GTPase cycle;R-HSA-9696273 RND1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3"]
["O00461","Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1","GOLIM4",1.073319865,0.083580468,"nochange",14622.4,15514.7,14609.3,15403.1,16702,15922.1,0.945682824,1.003391051,0.9448356,0.99617348,1.080177982,1.029739064,"extracellular","K23540",{"$nulls":3},"GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005796 Golgi lumen; GO:0005801 cis-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030139 endocytic vesicle; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;",{"$nulls":9},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811438 Intra-Golgi traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811438;https://reactome.org/PathwayBrowser/#/R-HSA-6811442"]
["O00462","Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3","MANBA",0.634236968,{"v":5.96559e-05,"d":"5.97E-05"},"down",9465.88,10263.1,9772.99,6319,6110.8,6281.44,1.17800246,1.277214274,1.216221446,0.78638199,0.760472078,0.781707752,"extracellular","K01192","E3.2.1.25; beta-mannosidase [EC:3.2.1.25]","hsa04142 Lysosome; hsa00511 Other glycan degradation","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0005975 carbohydrate metabolic process; GO:0006464 cellular protein modification process; GO:0006516 glycoprotein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009311 oligosaccharide metabolic process; GO:0009313 oligosaccharide catabolic process; GO:0009987 cellular process; GO:0016052 carbohydrate catabolic process; GO:0016192 vesicle-mediated transport; GO:0019538 protein metabolic process; GO:0030163 protein catabolic process; GO:0032940 secretion by cell; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005775 vacuolar lumen; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0035577 azurophil granule membrane; GO:0042582 azurophil granule; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0003824 catalytic activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0004567 beta-mannosidase activity; GO:0005488 binding; GO:0005537 mannose binding; GO:0015923 mannosidase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0030246 carbohydrate binding; GO:0036094 small molecule binding; GO:0048029 monosaccharide binding;","PF02836; PF17786; PF17753","PF02836 Glycosyl hydrolases family 2"," TIM barrel domain; PF17786 Mannosidase Ig/CBM-like domain; PF17753 Ig-fold domain","G","KOG2230","Predicted beta-mannosidase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation;R-HSA-71387 Metabolism of carbohydrates;R-HSA-8853383 Lysosomal oligosaccharide catabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-71387;https://reactome.org/PathwayBrowser/#/R-HSA-8853383"]
["O00463","TNF receptor-associated factor 5 OS=Homo sapiens OX=9606 GN=TRAF5 PE=1 SV=2","TRAF5",0.771024861,0.040469126,"nochange",4062.78,3683.64,4730,2927.7,3281.14,3410.79,1.103214375,1.000262038,1.284392459,0.79499277,0.890966485,0.926171872,"nucleus","K09849","TRAF5; TNF receptor-associated factor 5","hsa05170 Human immunodeficiency virus 1 infection; hsa04668 TNF signaling pathway; hsa05203 Viral carcinogenesis; hsa05200 Pathways in cancer; hsa05169 Epstein-Barr virus infection; hsa05222 Small cell lung cancer; hsa05163 Human cytomegalovirus infection; hsa05131 Shigellosis; hsa05168 Herpes simplex virus 1 infection; hsa04621 NOD-like receptor signaling pathway; hsa04657 IL-17 signaling pathway; hsa04064 NF-kappa B signaling pathway; hsa04217 Necroptosis","GO:0006355 regulation of transcription"," DNA-templated; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008284 positive regulation of cell population proliferation; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0042127 regulation of cell population proliferation; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0044093 positive regulation of molecular function; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0080090 regulation of primary metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0032991 protein-containing complex; GO:0035631 CD40 receptor complex; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043235 receptor complex; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0031996 thioesterase binding; GO:0042802 identical protein binding; GO:0044389 ubiquitin-like protein ligase binding;","PF00097","PF00097 Zinc finger"," C3HC4 type (RING finger)","T","KOG0297","TNF receptor-associated factor","WP5083 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING;WP3611 PHOTODYNAMIC THERAPYINDUCED AP1 SURVIVAL SIGNALING;WP2018 RANKLRANK SIGNALING PATHWAY;WP5039 SARSCOV2 INNATE IMMUNITY EVASION AND CELLSPECIFIC IMMUNE RESPONSE;WP4658 SMALL CELL LUNG CANCER;WP2036 TNFRELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5083_r120385;http://www.wikipathways.org/instance/WP3611_r120501;http://www.wikipathways.org/instance/WP2018_r120672;http://www.wikipathways.org/instance/WP5039_r120358;http://www.wikipathways.org/instance/WP4658_r119261;http://www.wikipathways.org/instance/WP2036_r120722"]
["O00468","Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6","AGRN",0.771576488,0.115991982,"nochange",23518.4,"NA",21307.4,17380.7,17411.8,17087.3,1.215979219,"NA",1.101663192,0.898639789,0.900247762,0.883470037,"extracellular","K06254","AGRN; agrin","hsa04512 ECM-receptor interaction","GO:0001523 retinoid metabolic process; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001941 postsynaptic membrane organization; GO:0002028 regulation of sodium ion transport; GO:0006022 aminoglycan metabolic process; GO:0006023 aminoglycan biosynthetic process; GO:0006024 glycosaminoglycan biosynthetic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006629 lipid metabolic process; GO:0006720 isoprenoid metabolic process; GO:0006721 terpenoid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006937 regulation of muscle contraction; GO:0006942 regulation of striated muscle contraction; GO:0006996 organelle organization; GO:0007009 plasma membrane organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007158 neuron cell-cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007213 G protein-coupled acetylcholine receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007528 neuromuscular junction development; GO:0008016 regulation of heart contraction; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010766 negative regulation of sodium ion transport; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016101 diterpenoid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030198 extracellular matrix organization; GO:0030203 glycosaminoglycan metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031532 actin cytoskeleton reorganization; GO:0032092 positive regulation of protein binding; GO:0032101 regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032409 regulation of transporter activity; GO:0032410 negative regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032413 negative regulation of ion transmembrane transporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032780 negative regulation of ATP-dependent activity; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033674 positive regulation of kinase activity; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0034763 negative regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034766 negative regulation of ion transmembrane transport; GO:0040008 regulation of growth; GO:0040012 regulation of locomotion; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042391 regulation of membrane potential; GO:0042551 neuron maturation; GO:0042981 regulation of apoptotic process; GO:0043062 extracellular structure organization; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043112 receptor metabolic process; GO:0043113 receptor clustering; GO:0043170 macromolecule metabolic process; GO:0043266 regulation of potassium ion transport; GO:0043267 negative regulation of potassium ion transport; GO:0043269 regulation of ion transport; GO:0043271 negative regulation of ion transport; GO:0043393 regulation of protein binding; GO:0043462 regulation of ATP-dependent activity; GO:0043523 regulation of neuron apoptotic process; GO:0043525 positive regulation of neuron apoptotic process; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0045161 neuronal ion channel clustering; GO:0045162 clustering of voltage-gated sodium channels; GO:0045213 neurotransmitter receptor metabolic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045887 positive regulation of synaptic assembly at neuromuscular junction; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046847 filopodium assembly; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0050920 regulation of chemotaxis; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051262 protein tetramerization; GO:0051270 regulation of cellular component movement; GO:0051290 protein heterotetramerization; GO:0051291 protein heterooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051668 localization within membrane; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0055117 regulation of cardiac muscle contraction; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060359 response to ammonium ion; GO:0060491 regulation of cell projection assembly; GO:0061024 membrane organization; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061098 positive regulation of protein tyrosine kinase activity; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071242 cellular response to ammonium ion; GO:0071310 cellular response to organic substance; GO:0071340 skeletal muscle acetylcholine-gated channel clustering; GO:0071495 cellular response to endogenous stimulus; GO:0071695 anatomical structure maturation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0086036 regulation of cardiac muscle cell membrane potential; GO:0090257 regulation of muscle system process; GO:0095500 acetylcholine receptor signaling pathway; GO:0098609 cell-cell adhesion; GO:0098916 anterograde trans-synaptic signaling; GO:0099173 postsynapse organization; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099601 regulation of neurotransmitter receptor activity; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901016 regulation of potassium ion transmembrane transporter activity; GO:1901017 negative regulation of potassium ion transmembrane transporter activity; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901379 regulation of potassium ion transmembrane transport; GO:1901380 negative regulation of potassium ion transmembrane transport; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902305 regulation of sodium ion transmembrane transport; GO:1902306 negative regulation of sodium ion transmembrane transport; GO:1902667 regulation of axon guidance; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903276 regulation of sodium ion export across plasma membrane; GO:1903277 negative regulation of sodium ion export across plasma membrane; GO:1903406 regulation of P-type sodium:potassium-exchanging transporter activity; GO:1903407 negative regulation of P-type sodium:potassium-exchanging transporter activity; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903522 regulation of blood circulation; GO:1903831 signal transduction involved in cellular response to ammonium ion; GO:1904062 regulation of cation transmembrane transport; GO:1904063 negative regulation of cation transmembrane transport; GO:1904396 regulation of neuromuscular junction development; GO:1904398 positive regulation of neuromuscular junction development; GO:1905144 response to acetylcholine; GO:1905145 cellular response to acetylcholine; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000273 positive regulation of signaling receptor activity; GO:2000539 regulation of protein geranylgeranylation; GO:2000541 positive regulation of protein geranylgeranylation; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2000650 negative regulation of sodium ion transmembrane transporter activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005604 basement membrane; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005794 Golgi apparatus; GO:0005796 Golgi lumen; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031012 extracellular matrix; GO:0031594 neuromuscular junction; GO:0031974 membrane-enclosed lumen; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043083 synaptic cleft; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044295 axonal growth cone; GO:0045121 membrane raft; GO:0045178 basal part of cell; GO:0045202 synapse; GO:0062023 collagen-containing extracellular matrix; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098857 membrane microdomain; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0002162 dystroglycan binding; GO:0004857 enzyme inhibitor activity; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005539 glycosaminoglycan binding; GO:0008047 enzyme activator activity; GO:0008201 heparin binding; GO:0019207 kinase regulator activity; GO:0019209 kinase activator activity; GO:0019838 growth factor binding; GO:0019887 protein kinase regulator activity; GO:0019955 cytokine binding; GO:0030234 enzyme regulator activity; GO:0030295 protein kinase activator activity; GO:0030296 protein tyrosine kinase activator activity; GO:0030297 transmembrane receptor protein tyrosine kinase activator activity; GO:0030545 signaling receptor regulator activity; GO:0030546 signaling receptor activator activity; GO:0030548 acetylcholine receptor regulator activity; GO:0031406 carboxylic acid binding; GO:0033691 sialic acid binding; GO:0035374 chondroitin sulfate binding; GO:0036094 small molecule binding; GO:0036122 BMP binding; GO:0038023 signaling receptor activity; GO:0042030 ATPase inhibitor activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043177 organic acid binding; GO:0043236 laminin binding; GO:0043237 laminin-1 binding; GO:0043394 proteoglycan binding; GO:0043395 heparan sulfate proteoglycan binding; GO:0044325 transmembrane transporter binding; GO:0046872 metal ion binding; GO:0050431 transforming growth factor beta binding; GO:0050840 extracellular matrix binding; GO:0060089 molecular transducer activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0060590 ATPase regulator activity; GO:0097367 carbohydrate derivative binding; GO:0098772 molecular function regulator; GO:0099602 neurotransmitter receptor regulator activity; GO:1901681 sulfur compound binding;","PF03146; PF07648; PF00050; PF00053; PF00008; PF00054","PF03146 Agrin NtA domain; PF07648 Kazal-type serine protease inhibitor domain; PF00050 Kazal-type serine protease inhibitor domain; PF00053 Laminin EGF domain; PF00008 EGF-like domain; PF00054 Laminin G domain","O","KOG3509","Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein","WP2572 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS;WP4148 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS","http://www.wikipathways.org/instance/WP2572_r119251;http://www.wikipathways.org/instance/WP4148_r110682",null,"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-1474244 Extracellular matrix organization;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism;R-HSA-1643685 Disease;R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism;R-HSA-196854 Metabolism of vitamins and cofactors;R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis;R-HSA-2022928 HS-GAG biosynthesis;R-HSA-2024096 HS-GAG degradation;R-HSA-216083 Integrin cell surface interactions;R-HSA-2187338 Visual phototransduction;R-HSA-3000171 Non-integrin membrane-ECM interactions;R-HSA-3000178 ECM proteoglycans;R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism;R-HSA-3560783 Defective B4GALT7 causes EDS"," progeroid type;R-HSA-3560801 Defective B3GAT3 causes JDSSDHD;R-HSA-3656237 Defective EXT2 causes exostoses 2;R-HSA-3656253 Defective EXT1 causes exostoses 1"," TRPS2 and CHDS;R-HSA-375165 NCAM signaling for neurite out-growth;R-HSA-3781865 Diseases of glycosylation;R-HSA-419037 NCAM1 interactions;R-HSA-422475 Axon guidance;R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1;R-HSA-5663205 Infectious disease;R-HSA-5668914 Diseases of metabolism;R-HSA-6806667 Metabolism of fat-soluble vitamins;R-HSA-71387 Metabolism of carbohydrates;R-HSA-9675108 Nervous system development;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694614 Attachment and Entry;R-HSA-9709957 Sensory Perception;R-HSA-975634 Retinoid metabolism and transport;R-HSA-9772572 Early SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1474244;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-1638091;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1793185;https://reactome.org/PathwayBrowser/#/R-HSA-196854;https://reactome.org/PathwayBrowser/#/R-HSA-1971475;https://reactome.org/PathwayBrowser/#/R-HSA-2022928;https://reactome.org/PathwayBrowser/#/R-HSA-2024096;https://reactome.org/PathwayBrowser/#/R-HSA-216083;https://reactome.org/PathwayBrowser/#/R-HSA-2187338;https://reactome.org/PathwayBrowser/#/R-HSA-3000171;https://reactome.org/PathwayBrowser/#/R-HSA-3000178;https://reactome.org/PathwayBrowser/#/R-HSA-3560782;https://reactome.org/PathwayBrowser/#/R-HSA-3560783;https://reactome.org/PathwayBrowser/#/R-HSA-3560801;https://reactome.org/PathwayBrowser/#/R-HSA-3656237;https://reactome.org/PathwayBrowser/#/R-HSA-3656253;https://reactome.org/PathwayBrowser/#/R-HSA-375165;https://reactome.org/PathwayBrowser/#/R-HSA-3781865;https://reactome.org/PathwayBrowser/#/R-HSA-419037;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-4420332;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-6806667;https://reactome.org/PathwayBrowser/#/R-HSA-71387;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694614;https://reactome.org/PathwayBrowser/#/R-HSA-9709957;https://reactome.org/PathwayBrowser/#/R-HSA-975634;https://reactome.org/PathwayBrowser/#/R-HSA-9772572","GLYCOLYSIS;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["O00469","Procollagen-lysine","2-oxoglutarate 5-dioxygenase 2 OS=Homo sapiens OX=9606 GN=PLOD2 PE=1 SV=2","PLOD2",1.237348042,0.01489641,"nochange",13347.1,15654.2,13749,18306.1,17275.1,17315.8,0.837269845,0.98199531,0.86248122,1.148350241,1.083675127,1.086228257,"extracellular","K13645","PLOD2; procollagen-lysine","2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]","hsa00310 Lysine degradation; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0001666 response to hypoxia; GO:0003006 developmental process involved in reproduction; GO:0006011 UDP-glucose metabolic process; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006520 cellular amino acid metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007295 growth of a germarium-derived egg chamber; GO:0008152 metabolic process; GO:0008544 epidermis development; GO:0008652 cellular amino acid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009066 aspartate family amino acid metabolic process; GO:0009067 aspartate family amino acid biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0016053 organic acid biosynthetic process; GO:0017185 peptidyl-lysine hydroxylation; GO:0018126 protein hydroxylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0032963 collagen metabolic process; GO:0032964 collagen biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0040007 growth; GO:0042221 response to chemical; GO:0042398 cellular modified amino acid biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0046394 carboxylic acid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046946 hydroxylysine metabolic process; GO:0046947 hydroxylysine biosynthetic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0070085 glycosylation; GO:0070482 response to oxygen levels; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0097359 UDP-glucosylation; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901607 alpha-amino acid biosynthetic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005791 rough endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030867 rough endoplasmic reticulum membrane; GO:0031090 organelle membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0098588 bounding membrane of organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008194 UDP-glycosyltransferase activity; GO:0008378 galactosyltransferase activity; GO:0008475 procollagen-lysine 5-dioxygenase activity; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0033823 procollagen glucosyltransferase activity; GO:0035250 UDP-galactosyltransferase activity; GO:0035251 UDP-glucosyltransferase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046527 glucosyltransferase activity; GO:0046983 protein dimerization activity; GO:0050211 procollagen galactosyltransferase activity; GO:0051213 dioxygenase activity; GO:0070815 peptidyl-lysine 5-dioxygenase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG1971","Lysyl hydroxylase","WP4018 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS;WP4786 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA","http://www.wikipathways.org/instance/WP4018_r117168;http://www.wikipathways.org/instance/WP4786_r117852",null,"R-HSA-1474244 Extracellular matrix organization;R-HSA-1474290 Collagen formation;R-HSA-1650814 Collagen biosynthesis and modifying enzymes","https://reactome.org/PathwayBrowser/#/R-HSA-1474244;https://reactome.org/PathwayBrowser/#/R-HSA-1474290;https://reactome.org/PathwayBrowser/#/R-HSA-1650814","EPITHELIAL MESENCHYMAL TRANSITION;GLYCOLYSIS;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["O00470","Homeobox protein Meis1 OS=Homo sapiens OX=9606 GN=MEIS1 PE=1 SV=1","MEIS1",0.869238453,0.373293903,"nochange",17888.6,14870.2,18601.1,16415.9,11136.9,17091.2,1.117992082,0.929349745,1.162521523,1.025952071,0.696027974,1.068156606,"nucleus","K15613","MEIS1; homeobox protein Meis1","hsa04550 Signaling pathways regulating pluripotency of stem cells; hsa05202 Transcriptional misregulation in cancer","GO:0001654 eye development; GO:0001655 urogenital system development; GO:0001742 oenocyte differentiation; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001752 compound eye photoreceptor fate commitment; GO:0001754 eye photoreceptor cell differentiation; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0003002 regionalization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006606 protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007275 multicellular organism development; GO:0007350 blastoderm segmentation; GO:0007379 segment specification; GO:0007380 specification of segmental identity"," head; GO:0007383 specification of segmental identity"," antennal segment; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007422 peripheral nervous system development; GO:0007423 sensory organ development; GO:0007431 salivary gland development; GO:0007432 salivary gland boundary specification; GO:0007444 imaginal disc development; GO:0007447 imaginal disc pattern formation; GO:0007449 proximal/distal pattern formation"," imaginal disc; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007479 leg disc proximal/distal pattern formation; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007481 haltere disc morphogenesis; GO:0007482 haltere development; GO:0007525 somatic muscle development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008104 protein localization; GO:0008284 positive regulation of cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009880 embryonic pattern specification; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009954 proximal/distal pattern formation; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010092 specification of animal organ identity; GO:0010160 formation of animal organ boundary; GO:0010171 body morphogenesis; GO:0010453 regulation of cell fate commitment; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0017038 protein import; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035216 haltere disc development; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035223 leg disc pattern formation; GO:0035239 tube morphogenesis; GO:0035272 exocrine system development; GO:0035282 segmentation; GO:0035287 head segmentation; GO:0035288 anterior head segmentation; GO:0035295 tube development; GO:0042127 regulation of cell population proliferation; GO:0042659 regulation of cell fate specification; GO:0042706 eye photoreceptor cell fate commitment; GO:0042886 amide transport; GO:0045165 cell fate commitment; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045638 negative regulation of myeloid cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046530 photoreceptor cell differentiation; GO:0046552 photoreceptor cell fate commitment; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048645 animal organ formation; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048663 neuron fate commitment; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048735 haltere morphogenesis; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048859 formation of anatomical boundary; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051960 regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060323 head morphogenesis; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0061326 renal tubule development; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0072001 renal system development; GO:0072002 Malpighian tubule development; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090596 sensory organ morphogenesis; GO:0097065 anterior head development; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000495 regulation of cell proliferation involved in compound eye morphogenesis; GO:2000497 positive regulation of cell proliferation involved in compound eye morphogenesis; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0090575 RNA polymerase II transcription regulator complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001221 transcription coregulator binding; GO:0001223 transcription coactivator binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;",null,null,"K","KOG0773","Transcription factor MEIS1 and related HOX domain proteins","WP2857 MESODERMAL COMMITMENT PATHWAY;WP5052 NEPHROGENESIS","http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP5052_r118777","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-5617472;https://reactome.org/PathwayBrowser/#/R-HSA-5619507","G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O00471","Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1","EXOC5",0.882947357,0.029144212,"nochange",18410.5,19080,17759,15710.3,17294.8,15777.3,1.061818538,1.100431695,1.024243525,0.906085537,0.997470968,0.909949737,"cytoplasm","K19984","EXOC5; exocyst complex component 5","hsa05132 Salmonella infection","GO:0001505 regulation of neurotransmitter levels; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001894 tissue homeostasis; GO:0002009 morphogenesis of an epithelium; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006893 Golgi to plasma membrane transport; GO:0006903 vesicle targeting; GO:0006904 vesicle docking involved in exocytosis; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007164 establishment of tissue polarity; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0008104 protein localization; GO:0008219 cell death; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016079 synaptic vesicle exocytosis; GO:0016080 synaptic vesicle targeting; GO:0016081 synaptic vesicle docking; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0023061 signal release; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042592 homeostatic process; GO:0044085 cellular component biogenesis; GO:0044782 cilium organization; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048278 vesicle docking; GO:0048489 synaptic vesicle transport; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0048871 multicellular organismal homeostasis; GO:0048872 homeostasis of number of cells; GO:0048873 homeostasis of number of cells within a tissue; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0060249 anatomical structure homeostasis; GO:0060271 cilium assembly; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0090522 vesicle tethering involved in exocytosis; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098876 vesicle-mediated transport to the plasma membrane; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099022 vesicle tethering; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering; GO:1904019 epithelial cell apoptotic process; GO:1905515 non-motile cilium assembly; GO:1990778 protein localization to cell periphery;","GO:0000145 exocyst; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005938 cell cortex; GO:0032991 protein-containing complex; GO:0071944 cell periphery; GO:0099023 vesicle tethering complex; GO:0099568 cytoplasmic region;","GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0047485 protein N-terminus binding; GO:0051020 GTPase binding;",null,null,"U","KOG3745","Exocyst subunit - Sec10p","WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP4352_r102218",null,"R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-199991 Membrane Trafficking;R-HSA-264876 Insulin processing;R-HSA-2980736 Peptide hormone metabolism;R-HSA-392499 Metabolism of proteins;R-HSA-5617833 Cilium Assembly;R-HSA-5620916 VxPx cargo-targeting to cilium;R-HSA-5620920 Cargo trafficking to the periciliary membrane;R-HSA-5653656 Vesicle-mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-1445148;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-264876;https://reactome.org/PathwayBrowser/#/R-HSA-2980736;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620916;https://reactome.org/PathwayBrowser/#/R-HSA-5620920;https://reactome.org/PathwayBrowser/#/R-HSA-5653656"]
["O00478","Butyrophilin subfamily 3 member A3 OS=Homo sapiens OX=9606 GN=BTN3A3 PE=1 SV=1","BTN3A3",0.959584855,0.729044653,"nochange",5542.51,5544.23,7032.21,6633.92,5603.29,5149.46,0.936613978,0.936904637,1.188354407,1.121048442,0.946885028,0.870193507,"plasma membrane","K06712",null,null,"GO:0001775 cell activation; GO:0001816 cytokine production; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002443 leukocyte mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002456 T cell mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0002790 peptide secretion; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0006629 lipid metabolic process; GO:0006810 transport; GO:0006955 immune response; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009306 protein secretion; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0019222 regulation of metabolic process; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0023052 signaling; GO:0030155 regulation of cell adhesion; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0032501 multicellular organismal process; GO:0032609 interferon-gamma production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0032943 mononuclear cell proliferation; GO:0032944 regulation of mononuclear cell proliferation; GO:0032945 negative regulation of mononuclear cell proliferation; GO:0033036 macromolecule localization; GO:0042098 T cell proliferation; GO:0042110 T cell activation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042130 negative regulation of T cell proliferation; GO:0042886 amide transport; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0046006 regulation of activated T cell proliferation; GO:0046007 negative regulation of activated T cell proliferation; GO:0046649 lymphocyte activation; GO:0046651 lymphocyte proliferation; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050670 regulation of lymphocyte proliferation; GO:0050672 negative regulation of lymphocyte proliferation; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050798 activated T cell proliferation; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050868 negative regulation of T cell activation; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051250 negative regulation of lymphocyte activation; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070661 leukocyte proliferation; GO:0070663 regulation of leukocyte proliferation; GO:0070664 negative regulation of leukocyte proliferation; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0090087 regulation of peptide transport; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903038 negative regulation of leukocyte cell-cell adhesion; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization;","GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0071944 cell periphery;","GO:0038023 signaling receptor activity; GO:0060089 molecular transducer activity;","PF07686","PF07686 Immunoglobulin V-set domain",{"$nulls":5},"Transcription factor","R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-8851680 Butyrophilin (BTN) family interactions","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-8851680"]
["O00483","Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens OX=9606 GN=NDUFA4 PE=1 SV=1","NDUFA4",1.305856826,2.59048E-4,"up",29523.4,28766.2,29090.5,36995.7,37533.2,39577,0.879169769,0.856621304,0.86627855,1.101685477,1.117691552,1.178553349,"mitochondria","K03948","NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0005751 mitochondrial respiratory chain complex IV; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045271 respiratory chain complex I; GO:0045277 respiratory chain complex IV; GO:0070069 cytochrome complex; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0005488 binding; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0044877 protein-containing complex binding; GO:0050136 NADH dehydrogenase (quinone) activity;",{"$nulls":5},"WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4922 MITOCHONDRIAL COMPLEX IV ASSEMBLY;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4922_r117792;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5628897 TP53 Regulates Metabolic Genes;R-HSA-611105 Respiratory electron transport;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953897 Cellular responses to stimuli;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5628897;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9711123","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O00487","26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1","PSMD14",0.995762265,0.990217235,"nochange",78538,62437.4,70458.3,68018.9,74866.9,67651.9,1.116729712,0.887795713,1.001844675,0.967158912,1.06453044,0.961940549,"cytoplasm","K03030","PSMD14; 26S proteasome regulatory subunit N11","hsa05017 Spinocerebellar ataxia; hsa05016 Huntington disease; hsa03050 Proteasome; hsa05169 Epstein-Barr virus infection; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease","GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006310 DNA recombination; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006955 immune response; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0016192 vesicle-mediated transport; GO:0016579 protein deubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032940 secretion by cell; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042176 regulation of protein catabolic process; GO:0043085 positive regulation of catalytic activity; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045862 positive regulation of proteolysis; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070536 protein K63-linked deubiquitination; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process;","GO:0000502 proteasome complex; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005838 proteasome regulatory particle; GO:0008541 proteasome regulatory particle"," lid subcomplex; GO:0012505 endomembrane system; GO:0022624 proteasome accessory complex; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031597 cytosolic proteasome complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1902494 catalytic complex; GO:1904813 ficolin-1-rich granule lumen; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004843 thiol-dependent deubiquitinase; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0008237 metallopeptidase activity; GO:0016504 peptidase activator activity; GO:0016787 hydrolase activity; GO:0019783 ubiquitin-like protein-specific protease activity; GO:0030234 enzyme regulator activity; GO:0044877 protein-containing complex binding; GO:0061133 endopeptidase activator activity; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0061578 Lys63-specific deubiquitinase activity; GO:0070628 proteasome binding; GO:0098772 molecular function regulator; GO:0101005 deubiquitinase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG1555","26S proteasome regulatory complex"," subunit RPN11","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP2359_r119918",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-5689901 Metalloprotease DUBs;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"MTORC1 SIGNALING;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O00488","Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2","ZNF593",1.740694051,0.145352864,"nochange",1233.89,973.739,"NA",1267.25,2440.69,2056.27,0.773905494,0.610736745,"NA",0.794829148,1.530819927,1.289708686,"nucleus","K14821",null,null,"GO:0000054 ribosomal subunit export from nucleus; GO:0000055 ribosomal large subunit export from nucleus; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0033750 ribosome localization; GO:0034613 cellular protein localization; GO:0042254 ribosome biogenesis; GO:0042886 amide transport; GO:0043392 negative regulation of DNA binding; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0045184 establishment of protein localization; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051101 regulation of DNA binding; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding; GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000677 regulation of transcription regulatory region DNA binding; GO:2000678 negative regulation of transcription regulatory region DNA binding; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0030684 preribosome; GO:0030687 preribosome"," large subunit precursor; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0008270 zinc ion binding; GO:0043021 ribonucleoprotein complex binding; GO:0043023 ribosomal large subunit binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044877 protein-containing complex binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0140110 transcription regulator activity;",null,null,"A","KOG3408","U1-like Zn-finger-containing protein"," probabl erole in RNA processing/splicing"]
["O00499","Myc box-dependent-interacting protein 1 OS=Homo sapiens OX=9606 GN=BIN1 PE=1 SV=1","BIN1",0.664395698,0.002679128,"down",13901.4,12693,12008.8,8144.32,8177.07,9326.41,1.298165009,1.185320073,1.121426904,0.760547229,0.763605547,0.870935238,"cytoplasm","K12562","AMPH; amphiphysin","hsa04666 Fc gamma R-mediated phagocytosis; hsa04144 Endocytosis","GO:0002027 regulation of heart rate; GO:0006810 transport; GO:0006897 endocytosis; GO:0006937 regulation of muscle contraction; GO:0006942 regulation of striated muscle contraction; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007009 plasma membrane organization; GO:0007010 cytoskeleton organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008016 regulation of heart contraction; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008283 cell population proliferation; GO:0008333 endosome to lysosome transport; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010466 negative regulation of peptidase activity; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010720 positive regulation of cell development; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010951 negative regulation of endopeptidase activity; GO:0010959 regulation of metal ion transport; GO:0014013 regulation of gliogenesis; GO:0014015 positive regulation of gliogenesis; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033292 T-tubule organization; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034762 regulation of transmembrane transport; GO:0034763 negative regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034766 negative regulation of ion transmembrane transport; GO:0035637 multicellular organismal signaling; GO:0042391 regulation of membrane potential; GO:0042692 muscle cell differentiation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043254 regulation of protein-containing complex assembly; GO:0043266 regulation of potassium ion transport; GO:0043267 negative regulation of potassium ion transport; GO:0043269 regulation of ion transport; GO:0043271 negative regulation of ion transport; GO:0043547 positive regulation of GTPase activity; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045685 regulation of glial cell differentiation; GO:0045687 positive regulation of glial cell differentiation; GO:0045759 negative regulation of action potential; GO:0045807 positive regulation of endocytosis; GO:0045822 negative regulation of heart contraction; GO:0045861 negative regulation of proteolysis; GO:0045932 negative regulation of muscle contraction; GO:0045988 negative regulation of striated muscle contraction; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048710 regulation of astrocyte differentiation; GO:0048711 positive regulation of astrocyte differentiation; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051647 nucleus localization; GO:0051649 establishment of localization in cell; GO:0051726 regulation of cell cycle; GO:0051924 regulation of calcium ion transport; GO:0051926 negative regulation of calcium ion transport; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0055001 muscle cell development; GO:0055117 regulation of cardiac muscle contraction; GO:0055118 negative regulation of cardiac muscle contraction; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060627 regulation of vesicle-mediated transport; GO:0060988 lipid tube assembly; GO:0060990 lipid tube assembly involved in organelle fission; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0061337 cardiac conduction; GO:0065003 protein-containing complex assembly; GO:0065005 protein-lipid complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071825 protein-lipid complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0086004 regulation of cardiac muscle cell contraction; GO:0086091 regulation of heart rate by cardiac conduction; GO:0090066 regulation of anatomical structure size; GO:0090257 regulation of muscle system process; GO:0098657 import into cell; GO:0098900 regulation of action potential; GO:0098901 regulation of cardiac muscle cell action potential; GO:0098911 regulation of ventricular cardiac muscle cell action potential; GO:0110053 regulation of actin filament organization; GO:1901379 regulation of potassium ion transmembrane transport; GO:1901380 negative regulation of potassium ion transmembrane transport; GO:1902003 regulation of amyloid-beta formation; GO:1902430 negative regulation of amyloid-beta formation; GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; GO:1902991 regulation of amyloid precursor protein catabolic process; GO:1902992 negative regulation of amyloid precursor protein catabolic process; GO:1903115 regulation of actin filament-based movement; GO:1903169 regulation of calcium ion transmembrane transport; GO:1903170 negative regulation of calcium ion transmembrane transport; GO:1903522 regulation of blood circulation; GO:1903523 negative regulation of blood circulation; GO:1903946 negative regulation of ventricular cardiac muscle cell action potential; GO:1904062 regulation of cation transmembrane transport; GO:1904063 negative regulation of cation transmembrane transport; GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; GO:1905245 regulation of aspartic-type peptidase activity; GO:1905246 negative regulation of aspartic-type peptidase activity; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005886 plasma membrane; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0030133 transport vesicle; GO:0030315 T-tubule; GO:0030424 axon; GO:0031410 cytoplasmic vesicle; GO:0031674 I band; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0032994 protein-lipid complex; GO:0033268 node of Ranvier; GO:0042383 sarcolemma; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043194 axon initial segment; GO:0043196 varicosity; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0043679 axon terminus; GO:0044300 cerebellar mossy fiber; GO:0044304 main axon; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0055037 recycling endosome; GO:0060987 lipid tube; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0002020 protease binding; GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0019899 enzyme binding; GO:0030276 clathrin binding; GO:0042802 identical protein binding; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0048156 tau protein binding; GO:0051015 actin filament binding; GO:0051020 GTPase binding; GO:0051087 chaperone binding; GO:0070063 RNA polymerase binding;","PF03114; PF14604","PF03114 BAR domain; PF14604 Variant SH3 domain","U","KOG3771","Amphiphysin","WP4754 IL18 SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP3888_r116782","Transcription factor","R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828","MITOTIC SPINDLE;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["O00505","Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2","KPNA3",1.413844686,{"v":1.5164e-05,"d":"1.52E-05"},"up",78402.4,75159.9,75399.2,108188,107317,108211,0.85115533,0.81595397,0.818551868,1.174514975,1.165059189,1.174764668,"cytoplasm","K23583","KPNA3_4; importin subunit alpha-4/3","hsa05132 Salmonella infection; hsa03013 Nucleocytoplasmic transport; hsa05207 Chemical carcinogenesis - receptor activation","GO:0000003 reproduction; GO:0000280 nuclear division; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006999 nuclear pore organization; GO:0007049 cell cycle; GO:0007127 meiosis I; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0008104 protein localization; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0019048 modulation by virus of host process; GO:0019054 modulation by virus of host cellular process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035821 modulation of process of another organism; GO:0042886 amide transport; GO:0043933 protein-containing complex organization; GO:0044003 modulation by symbiont of host process; GO:0044068 modulation by symbiont of host cellular process; GO:0044085 cellular component biogenesis; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051321 meiotic cell cycle; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051701 biological process involved in interaction with host; GO:0061982 meiosis I cell cycle process; GO:0065003 protein-containing complex assembly; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0140013 meiotic nuclear division; GO:1903046 meiotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005048 signal sequence binding; GO:0005102 signaling receptor binding; GO:0005112 Notch binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008092 cytoskeletal protein binding; GO:0008139 nuclear localization sequence binding; GO:0017022 myosin binding; GO:0033218 amide binding; GO:0042277 peptide binding;",null,null,"U","KOG0166","Karyopherin (importin) alpha",{"$nulls":3},"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168276 NS1 Mediated Effects on Host Pathways;R-HSA-5663205 Infectious disease;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1169408;https://reactome.org/PathwayBrowser/#/R-HSA-1169410;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168276;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-913531"]
["O00506","Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1","STK25",1.485395677,0.047079958,"nochange",3378.28,5178.32,4180.04,6152.57,5593.22,7173.16,0.640319135,0.981498686,0.792284712,1.166158015,1.060138825,1.359600627,"cytoplasm","K08838",null,null,"GO:0000165 MAPK cascade; GO:0000302 response to reactive oxygen species; GO:0000902 cell morphogenesis; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007043 cell-cell junction assembly; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0010256 endomembrane system organization; GO:0010421 hydrogen peroxide-mediated programmed cell death; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019991 septate junction assembly; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0033673 negative regulation of kinase activity; GO:0033674 positive regulation of kinase activity; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034599 cellular response to oxidative stress; GO:0034614 cellular response to reactive oxygen species; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0036473 cell death in response to oxidative stress; GO:0036474 cell death in response to hydrogen peroxide; GO:0036481 intrinsic apoptotic signaling pathway in response to hydrogen peroxide; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042542 response to hydrogen peroxide; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043297 apical junction assembly; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045216 cell-cell junction organization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046677 response to antibiotic; GO:0046777 protein autophosphorylation; GO:0048308 organelle inheritance; GO:0048313 Golgi inheritance; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051645 Golgi localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051683 establishment of Golgi localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060281 regulation of oocyte development; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060438 trachea development; GO:0060439 trachea morphogenesis; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070301 cellular response to hydrogen peroxide; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070887 cellular response to chemical stimulus; GO:0071236 cellular response to antibiotic; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090168 Golgi reassembly; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097237 cellular response to toxic substance; GO:0097468 programmed cell death in response to reactive oxygen species; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903358 regulation of Golgi organization; GO:1905879 regulation of oogenesis; GO:2000026 regulation of multicellular organismal development; GO:2000241 regulation of reproductive process; GO:2001135 regulation of endocytic recycling; GO:2001137 positive regulation of endocytic recycling;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0031090 organelle membrane; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045177 apical part of cell; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098592 cytoplasmic side of apical plasma membrane; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008349 MAP kinase kinase kinase kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0051019 mitogen-activated protein kinase binding; GO:0140096 catalytic activity"," acting on a protein;","PF00069","PF00069 Protein kinase domain","T","KOG0201","Serine/threonine protein kinase",{"$nulls":5},"REACTIVE OXYGEN SPECIES PATHWAY;UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["O00507","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y OS=Homo sapiens OX=9606 GN=USP9Y PE=2 SV=2","USP9Y",0.733537271,0.129665005,"nochange",2954.46,3118.43,2142.03,1589.53,2157.86,2278.56,1.244780691,1.313864953,0.902485593,0.669704871,0.909155129,0.960008764,"plasma membrane","K11840",null,null,"GO:0000003 reproduction; GO:0001654 eye development; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001745 compound eye morphogenesis; GO:0003002 regionalization; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0007097 nuclear migration; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007349 cellularization; GO:0007389 pattern specification process; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008354 germ cell migration; GO:0008583 mystery cell differentiation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009887 animal organ morphogenesis; GO:0009892 negative regulation of metabolic process; GO:0009950 dorsal/ventral axis specification; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0016579 protein deubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0035190 syncytial nuclear migration; GO:0035192 nuclear cortical migration; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045861 negative regulation of proteolysis; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048592 eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051647 nucleus localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090596 sensory organ morphogenesis; GO:0098657 import into cell; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;","GO:0003824 catalytic activity; GO:0004843 thiol-dependent deubiquitinase; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0016787 hydrolase activity; GO:0019783 ubiquitin-like protein-specific protease activity; GO:0101005 deubiquitinase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG1866","Ubiquitin carboxyl-terminal hydrolase"]
["O00512","B-cell CLL/lymphoma 9 protein OS=Homo sapiens OX=9606 GN=BCL9 PE=1 SV=4","BCL9",1.198328569,0.200660217,"nochange",1433.33,1671.99,2043.56,1946.88,2334.97,1888.2,0.759787365,0.886297556,1.083261404,1.032012743,1.237733602,1.00090733,"nucleus","K22649",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0009611 response to wounding; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0014706 striated muscle tissue development; GO:0014902 myotube differentiation; GO:0014908 myotube differentiation involved in skeletal muscle regeneration; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019827 stem cell population maintenance; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0031099 regeneration; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035019 somatic stem cell population maintenance; GO:0035914 skeletal muscle cell differentiation; GO:0040007 growth; GO:0042060 wound healing; GO:0042246 tissue regeneration; GO:0042692 muscle cell differentiation; GO:0043403 skeletal muscle tissue regeneration; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048589 developmental growth; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060070 canonical Wnt signaling pathway; GO:0060255 regulation of macromolecule metabolic process; GO:0060537 muscle tissue development; GO:0060538 skeletal muscle organ development; GO:0061061 muscle structure development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0098727 maintenance of cell number; GO:0198738 cell-cell signaling by wnt; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904837 beta-catenin-TCF complex assembly; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005801 cis-Golgi network; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex; GO:1990907 beta-catenin-TCF complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding;",{"$nulls":5},"WP4905 1Q211 COPY NUMBER VARIATION SYNDROME;WP363 WNT SIGNALING PATHWAY;WP3658 WNTBETACATENIN SIGNALING PATHWAY IN LEUKEMIA","http://www.wikipathways.org/instance/WP4905_r115772;http://www.wikipathways.org/instance/WP363_r120695;http://www.wikipathways.org/instance/WP3658_r116670",null,"R-HSA-162582 Signal Transduction;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex;R-HSA-3769402 Deactivation of the beta-catenin transactivating complex","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-201681;https://reactome.org/PathwayBrowser/#/R-HSA-201722;https://reactome.org/PathwayBrowser/#/R-HSA-3769402"]
["O00522","Krev interaction trapped protein 1 OS=Homo sapiens OX=9606 GN=KRIT1 PE=1 SV=2","KRIT1",0.497539708,0.007821839,"down",3744.63,4644.36,5237.44,2738.25,1978.95,2062.49,1.101031455,1.365578562,1.539961541,0.805126109,0.581869557,0.606432776,"cytoplasm","nucleus","K17705","KRIT1; Krev interaction trapped protein 1","hsa04015 Rap1 signaling pathway","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001570 vasculogenesis; GO:0001885 endothelial cell development; GO:0001886 endothelial cell morphogenesis; GO:0001936 regulation of endothelial cell proliferation; GO:0001937 negative regulation of endothelial cell proliferation; GO:0001944 vasculature development; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0003002 regionalization; GO:0003007 heart morphogenesis; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003015 heart process; GO:0003158 endothelium development; GO:0003159 morphogenesis of an endothelium; GO:0003382 epithelial cell morphogenesis; GO:0006996 organelle organization; GO:0007033 vacuole organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007507 heart development; GO:0008015 blood circulation; GO:0008285 negative regulation of cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0010594 regulation of endothelial cell migration; GO:0010596 negative regulation of endothelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010633 negative regulation of epithelial cell migration; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0016525 negative regulation of angiogenesis; GO:0019725 cellular homeostasis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030855 epithelial cell differentiation; GO:0030856 regulation of epithelial cell differentiation; GO:0030857 negative regulation of epithelial cell differentiation; GO:0032092 positive regulation of protein binding; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032878 regulation of establishment or maintenance of cell polarity; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042127 regulation of cell population proliferation; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043393 regulation of protein binding; GO:0044093 positive regulation of molecular function; GO:0045446 endothelial cell differentiation; GO:0045454 cell redox homeostasis; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045601 regulation of endothelial cell differentiation; GO:0045602 negative regulation of endothelial cell differentiation; GO:0045765 regulation of angiogenesis; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050678 regulation of epithelial cell proliferation; GO:0050680 negative regulation of epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051716 cellular response to stimulus; GO:0060047 heart contraction; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0061154 endothelial tube morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072554 blood vessel lumenization; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1904035 regulation of epithelial cell apoptotic process; GO:1904036 negative regulation of epithelial cell apoptotic process; GO:2000026 regulation of multicellular organismal development; GO:2000114 regulation of establishment of cell polarity; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2000351 regulation of endothelial cell apoptotic process; GO:2000352 negative regulation of endothelial cell apoptotic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0016327 apicolateral plasma membrane; GO:0030054 cell junction; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045177 apical part of cell; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0015631 tubulin binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF16705; PF00373","PF16705 NUDIX"," or N-terminal NPxY motif-rich","  region of KRIT; PF00373 FERM central domain","T","KOG4335","FERM domain-containing protein KRIT1"]
["O00541","Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1","PES1",1.074443931,0.074961064,"nochange",65269.6,68740.3,68680.9,70400.4,76155.4,71224.1,0.931379047,0.980904971,0.98005735,1.004594137,1.086716387,1.016348107,"cytoplasm","nucleus","K14843",null,null,"GO:0000460 maturation of 5.8S rRNA; GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000470 maturation of LSU-rRNA; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007000 nucleolus organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010467 gene expression; GO:0010876 lipid localization; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0019915 lipid storage; GO:0022008 neurogenesis; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030154 cell differentiation; GO:0031016 pancreas development; GO:0031017 exocrine pancreas development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034470 ncRNA processing; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0035272 exocrine system development; GO:0042063 gliogenesis; GO:0042254 ribosome biogenesis; GO:0042273 ribosomal large subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048709 oligodendrocyte differentiation; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051179 localization; GO:0051235 maintenance of location; GO:0051641 cellular localization; GO:0051726 regulation of cell cycle; GO:0055123 digestive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0000793 condensed chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030684 preribosome; GO:0030686 90S preribosome; GO:0030687 preribosome"," large subunit precursor; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070545 PeBoW complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG2481","Protein required for normal rRNA processing",{"$nulls":3},"R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V2","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2"]
["O00560","Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1","SDCBP",1.732290502,0.000687044,"up",12573.5,10737.7,11037.6,20829.2,18689,19983.9,0.803838855,0.686473971,0.705646936,1.331635605,1.194810066,1.277594568,"cytoskeleton","K17254",null,null,"GO:0001558 regulation of cell growth; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002090 regulation of receptor internalization; GO:0002091 negative regulation of receptor internalization; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006929 substrate-dependent cell migration; GO:0006930 substrate-dependent cell migration"," cell extension; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0008284 positive regulation of cell population proliferation; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010717 regulation of epithelial to mesenchymal transition; GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0017157 regulation of exocytosis; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030162 regulation of proteolysis; GO:0030307 positive regulation of cell growth; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034613 cellular protein localization; GO:0035556 intracellular signal transduction; GO:0036230 granulocyte activation; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042886 amide transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045806 negative regulation of endocytosis; GO:0045861 negative regulation of proteolysis; GO:0045921 positive regulation of exocytosis; GO:0045927 positive regulation of growth; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048013 ephrin receptor signaling pathway; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048261 negative regulation of receptor-mediated endocytosis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation; GO:0060627 regulation of vesicle-mediated transport; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090150 establishment of protein localization to membrane; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0098916 anterograde trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903541 regulation of exosomal secretion; GO:1903543 positive regulation of exosomal secretion; GO:1903551 regulation of extracellular exosome assembly; GO:1903553 positive regulation of extracellular exosome assembly; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus; GO:2000026 regulation of multicellular organismal development; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005895 interleukin-5 receptor complex; GO:0005912 adherens junction; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030054 cell junction; GO:0030141 secretory granule; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043235 receptor complex; GO:0045121 membrane raft; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0070062 extracellular exosome; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex; GO:0098857 membrane microdomain; GO:0099503 secretory vesicle; GO:1903561 extracellular vesicle;","GO:0001664 G protein-coupled receptor binding; GO:0005102 signaling receptor binding; GO:0005109 frizzled binding; GO:0005126 cytokine receptor binding; GO:0005137 interleukin-5 receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008022 protein C-terminus binding; GO:0008092 cytoskeletal protein binding; GO:0008093 cytoskeletal anchor activity; GO:0008289 lipid binding; GO:0019838 growth factor binding; GO:0030674 protein-macromolecule adaptor activity; GO:0035091 phosphatidylinositol binding; GO:0042043 neurexin family protein binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043394 proteoglycan binding; GO:0045545 syndecan binding; GO:0046875 ephrin receptor binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0047485 protein N-terminus binding; GO:0050839 cell adhesion molecule binding; GO:0060090 molecular adaptor activity; GO:0070851 growth factor receptor binding; GO:0097367 carbohydrate derivative binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00595","PF00595 PDZ domain","K","KOG0849","Transcription factor PRD and related proteins"," contain PAX and HOX domains","WP2858 ECTODERM DIFFERENTIATION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2858_r116763;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1266738 Developmental Biology;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-373760 L1CAM interactions;R-HSA-3928664 Ephrin signaling;R-HSA-422475 Axon guidance;R-HSA-447043 Neurofascin interactions;R-HSA-5213460 RIPK1-mediated regulated necrosis;R-HSA-5218859 Regulated Necrosis;R-HSA-5357801 Programmed Cell Death;R-HSA-5675482 Regulation of necroptotic cell death;R-HSA-6798695 Neutrophil degranulation;R-HSA-9675108 Nervous system development","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-373760;https://reactome.org/PathwayBrowser/#/R-HSA-3928664;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-447043;https://reactome.org/PathwayBrowser/#/R-HSA-5213460;https://reactome.org/PathwayBrowser/#/R-HSA-5218859;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-5675482;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-9675108","DNA REPAIR;HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O00562","Membrane-associated phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNM1 PE=1 SV=4","PITPNM1",0.476724154,0.060720567,"nochange",3301.17,2360.47,2722.76,1509.46,684.506,1803.08,1.599733989,1.143874472,1.31943878,0.731478375,0.331708913,0.873765471,"cytoplasm","K24069",null,null,"GO:0003008 system process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007600 sensory perception; GO:0007602 phototransduction; GO:0007603 phototransduction"," visible light; GO:0007606 sensory perception of chemical stimulus; GO:0007608 sensory perception of smell; GO:0008152 metabolic process; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009584 detection of visible light; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010876 lipid localization; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015914 phospholipid transport; GO:0016056 rhodopsin mediated signaling pathway; GO:0016059 deactivation of rhodopsin mediated signaling; GO:0019637 organophosphate metabolic process; GO:0022400 regulation of rhodopsin mediated signaling pathway; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030001 metal ion transport; GO:0032101 regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034220 ion transmembrane transport; GO:0035556 intracellular signal transduction; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048513 animal organ development; GO:0048583 regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0060322 head development; GO:0065007 biological regulation; GO:0070588 calcium ion transmembrane transport; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0104004 cellular response to environmental stimulus; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005790 smooth endoplasmic reticulum; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005929 cilium; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016028 rhabdomere; GO:0016029 subrhabdomeral cisterna; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0035869 ciliary transition zone; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0045202 synapse; GO:0071781 endoplasmic reticulum cisternal network; GO:0071944 cell periphery; GO:0098827 endoplasmic reticulum subcompartment; GO:0120025 plasma membrane bounded cell projection; GO:0120082 smooth endoplasmic reticulum cisterna; GO:1990904 ribonucleoprotein complex;","GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005215 transporter activity; GO:0005319 lipid transporter activity; GO:0005388 P-type calcium transporter activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005548 phospholipid transporter activity; GO:0008289 lipid binding; GO:0008324 cation transmembrane transporter activity; GO:0008525 phosphatidylcholine transporter activity; GO:0008526 phosphatidylinositol transfer activity; GO:0015075 ion transmembrane transporter activity; GO:0015085 calcium ion transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015662 P-type ion transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019829 ATPase-coupled cation transmembrane transporter activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0022804 active transmembrane transporter activity; GO:0022853 active ion transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0030971 receptor tyrosine kinase binding; GO:0031210 phosphatidylcholine binding; GO:0035091 phosphatidylinositol binding; GO:0042625 ATPase-coupled ion transmembrane transporter activity; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046873 metal ion transmembrane transporter activity; GO:0050997 quaternary ammonium group binding; GO:0070300 phosphatidic acid binding; GO:0070405 ammonium ion binding; GO:1990050 phosphatidic acid transfer activity; GO:1990782 protein tyrosine kinase binding;",null,null,"IT","KOG3668","Phosphatidylinositol transfer protein",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483206 Glycerophospholipid biosynthesis;R-HSA-1483226 Synthesis of PI;R-HSA-1483257 Phospholipid metabolism;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483206;https://reactome.org/PathwayBrowser/#/R-HSA-1483226;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["O00566","U3 small nucleolar ribonucleoprotein protein MPP10 OS=Homo sapiens OX=9606 GN=MPHOSPH10 PE=1 SV=2","MPHOSPH10",1.043612146,0.351009113,"nochange",14379.5,14721.5,14609.3,16357.8,14872.1,14386.7,0.96585687,0.988828673,0.981292309,1.098737334,0.998944327,0.966340486,"nucleus","K14559","MPP10; U3 small nucleolar RNA-associated protein MPP10","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000375 RNA splicing"," via transesterification reactions; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030490 maturation of SSU-rRNA; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0035303 regulation of dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0042254 ribosome biogenesis; GO:0042274 ribosomal small subunit biogenesis; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051174 regulation of phosphorus metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005732 sno(s)RNA-containing ribonucleoprotein complex; GO:0030684 preribosome; GO:0030686 90S preribosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032040 small-subunit processome; GO:0032991 protein-containing complex; GO:0034457 Mpp10 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"A","KOG2600","U3 small nucleolar ribonucleoprotein (snoRNP) subunit - Mpp10p",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V2","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2"]
["O00567","Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4","NOP56",0.980756716,0.562618069,"nochange",136572,139018,146999,136021,134409,144027,0.978956951,0.996490038,1.053698363,0.975007347,0.963452427,1.032394874,"nucleus","K14564","NOP56; nucleolar protein 56","hsa05017 Spinocerebellar ataxia; hsa03008 Ribosome biogenesis in eukaryotes","GO:0000154 rRNA modification; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005732 sno(s)RNA-containing ribonucleoprotein complex; GO:0030684 preribosome; GO:0031428 box C/D RNP complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032040 small-subunit processome; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070761 pre-snoRNP complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0030515 snoRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990226 histone methyltransferase binding;","PF08156","PF08156 NOP5NT (NUC127) domain","AJ","KOG2573","Ribosome biogenesis protein - Nop56p/Sik1p",{"$nulls":3},"R-HSA-390466 Chaperonin-mediated protein folding;R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins;R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-390466;https://reactome.org/PathwayBrowser/#/R-HSA-390471;https://reactome.org/PathwayBrowser/#/R-HSA-391251;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","E2F TARGETS;MYC TARGETS V1;MYC TARGETS V2;UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["O00571","ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3","DDX3X",1.112047144,0.000487782,"up",78435.2,81097.7,80107.3,89033.9,88276.1,89181.2,0.929820201,0.961383151,0.949642326,1.055463858,1.04648042,1.057210045,"nucleus","K11594","DDX3X; ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]","hsa04622 RIG-I-like receptor signaling pathway; hsa05161 Hepatitis B; hsa05203 Viral carcinogenesis","GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0001558 regulation of cell growth; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002168 instar larval development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006970 response to osmotic stress; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007530 sex determination; GO:0007552 metamorphosis; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010466 negative regulation of peptidase activity; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010501 RNA secondary structure unwinding; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010623 programmed cell death involved in cell development; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010951 negative regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0012502 induction of programmed cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0016070 RNA metabolic process; GO:0016192 vesicle-mediated transport; GO:0016246 RNA interference; GO:0016441 posttranscriptional gene silencing; GO:0017148 negative regulation of translation; GO:0018992 germ-line sex determination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022612 gland morphogenesis; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030307 positive regulation of cell growth; GO:0030308 negative regulation of cell growth; GO:0030718 germ-line stem cell population maintenance; GO:0031047 gene silencing by RNA; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032392 DNA geometric change; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032508 DNA duplex unwinding; GO:0032642 regulation of chemokine production; GO:0032648 regulation of interferon-beta production; GO:0032722 positive regulation of chemokine production; GO:0032728 positive regulation of interferon-beta production; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0033993 response to lipid; GO:0034063 stress granule assembly; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035070 salivary gland histolysis; GO:0035071 salivary gland cell autophagic cell death; GO:0035072 ecdysone-mediated induction of salivary gland cell autophagic cell death; GO:0035075 response to ecdysone; GO:0035078 induction of programmed cell death by ecdysone; GO:0035081 induction of programmed cell death by hormones; GO:0035194 post-transcriptional gene silencing by RNA; GO:0035272 exocrine system development; GO:0035556 intracellular signal transduction; GO:0036098 male germ-line stem cell population maintenance; GO:0036230 granulocyte activation; GO:0036314 response to sterol; GO:0040008 regulation of growth; GO:0040019 positive regulation of embryonic development; GO:0040021 hermaphrodite germ-line sex determination; GO:0040029 regulation of gene expression"," epigenetic; GO:0042006 masculinization of hermaphroditic germ-line; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042254 ribosome biogenesis; GO:0042255 ribosome assembly; GO:0042256 mature ribosome assembly; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043043 peptide biosynthetic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043254 regulation of protein-containing complex assembly; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043549 regulation of kinase activity; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0045087 innate immune response; GO:0045321 leukocyte activation; GO:0045727 positive regulation of translation; GO:0045787 positive regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045948 positive regulation of translational initiation; GO:0045995 regulation of embryonic development; GO:0046483 heterocycle metabolic process; GO:0046685 response to arsenic-containing substance; GO:0046903 secretion; GO:0048102 autophagic cell death; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048707 instar larval or pupal morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051641 cellular localization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060033 anatomical structure regression; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071103 DNA conformation change; GO:0071214 cellular response to abiotic stimulus; GO:0071243 cellular response to arsenic-containing substance; GO:0071470 cellular response to osmotic stress; GO:0071649 regulation of chemokine (C-C motif) ligand 5 production; GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080154 regulation of fertilization; GO:0090068 positive regulation of cell cycle process; GO:0090263 positive regulation of canonical Wnt signaling pathway; GO:0090304 nucleic acid metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097191 extrinsic apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097305 response to alcohol; GO:0098727 maintenance of cell number; GO:0098813 nuclear chromosome segregation; GO:0104004 cellular response to environmental stimulus; GO:0140014 mitotic nuclear division; GO:0198738 cell-cell signaling by wnt; GO:1900087 positive regulation of G1/S transition of mitotic cell cycle; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901654 response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902808 positive regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903608 protein localization to cytoplasmic stress granule; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:1905516 positive regulation of fertilization; GO:2000026 regulation of multicellular organismal development; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005829 cytosol; GO:0010494 cytoplasmic stress granule; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016442 RISC complex; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0019867 outer membrane; GO:0030141 secretory granule; GO:0031090 organelle membrane; GO:0031332 RNAi effector complex; GO:0031410 cytoplasmic vesicle; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0043025 neuronal cell body; GO:0043186 P granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045495 pole plasm; GO:0060205 cytoplasmic vesicle lumen; GO:0060293 germ plasm; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003723 RNA binding; GO:0003724 RNA helicase activity; GO:0003725 double-stranded RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0008134 transcription factor binding; GO:0008143 poly(A) binding; GO:0008186 ATP-dependent activity"," acting on RNA; GO:0008190 eukaryotic initiation factor 4E binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019207 kinase regulator activity; GO:0019209 kinase activator activity; GO:0019887 protein kinase regulator activity; GO:0030234 enzyme regulator activity; GO:0030295 protein kinase activator activity; GO:0031369 translation initiation factor binding; GO:0033592 RNA strand annealing activity; GO:0035613 RNA stem-loop binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043021 ribonucleoprotein complex binding; GO:0043024 ribosomal small subunit binding; GO:0043273 CTPase activity; GO:0043539 protein serine/threonine kinase activator activity; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0048027 mRNA 5'-UTR binding; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:0140097 catalytic activity"," acting on DNA; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF00270; PF00271","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain","A","KOG0335","ATP-dependent RNA helicase","WP4666 HEPATITIS B INFECTION;WP3865 NOVEL INTRACELLULAR COMPONENTS OF RIGILIKE RECEPTOR RLR PATHWAY","http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP3865_r106524",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O00584","Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2","RNASET2",1.015936985,0.827553572,"nochange",3504.92,2463.5,3751.11,3442.72,3329.57,3102.14,1.073265435,0.754365121,1.148652952,1.054218749,1.019570317,0.949927427,"extracellular","K01166",null,null,"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0016075 rRNA catabolic process; GO:0016192 vesicle-mediated transport; GO:0019439 aromatic compound catabolic process; GO:0032940 secretion by cell; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0034660 ncRNA metabolic process; GO:0034661 ncRNA catabolic process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0042582 azurophil granule; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004540 ribonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0140098 catalytic activity"," acting on RNA;","PF00445","PF00445 Ribonuclease T2 family","A","KOG1642","Ribonuclease"," T2 family","WP4705 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING","http://www.wikipathways.org/instance/WP4705_r119081",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O00592","Podocalyxin OS=Homo sapiens OX=9606 GN=PODXL PE=1 SV=2","PODXL",1.357655957,0.000332234,"up",23237.6,22994.3,23261.7,31088.2,30216.1,33044.1,0.85097594,0.842066137,0.851858498,1.138469989,1.106533123,1.210096312,"endoplasmic reticulum","K06817","PODXL; podocalyxin-like","hsa05132 Salmonella infection","GO:0001655 urogenital system development; GO:0001822 kidney development; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002376 immune system process; GO:0003008 system process; GO:0003014 renal system process; GO:0003094 glomerular filtration; GO:0006928 movement of cell or subcellular component; GO:0007162 negative regulation of cell adhesion; GO:0007275 multicellular organism development; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0016477 cell migration; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030855 epithelial cell differentiation; GO:0031344 regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032530 regulation of microvillus organization; GO:0032534 regulation of microvillus assembly; GO:0032835 glomerulus development; GO:0032879 regulation of localization; GO:0033628 regulation of cell adhesion mediated by integrin; GO:0033630 positive regulation of cell adhesion mediated by integrin; GO:0033632 regulation of cell-cell adhesion mediated by integrin; GO:0033634 positive regulation of cell-cell adhesion mediated by integrin; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035850 epithelial cell differentiation involved in kidney development; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0044087 regulation of cellular component biogenesis; GO:0045785 positive regulation of cell adhesion; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050900 leukocyte migration; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051674 localization of cell; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060562 epithelial tube morphogenesis; GO:0061005 cell differentiation involved in kidney development; GO:0061318 renal filtration cell differentiation; GO:0065007 biological regulation; GO:0072001 renal system development; GO:0072006 nephron development; GO:0072009 nephron epithelium development; GO:0072010 glomerular epithelium development; GO:0072015 glomerular visceral epithelial cell development; GO:0072073 kidney epithelium development; GO:0072112 glomerular visceral epithelial cell differentiation; GO:0072175 epithelial tube formation; GO:0072310 glomerular epithelial cell development; GO:0072311 glomerular epithelial cell differentiation; GO:0097205 renal filtration; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0001726 ruffle; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005902 microvillus; GO:0005911 cell-cell junction; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016324 apical plasma membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030175 filopodium; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031528 microvillus membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0036056 filtration diaphragm; GO:0036057 slit diaphragm; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045177 apical part of cell; GO:0070013 intracellular organelle lumen; GO:0070062 extracellular exosome; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0120025 plasma membrane bounded cell projection; GO:1903561 extracellular vesicle;",{"$nulls":6},"WP2858 ECTODERM DIFFERENTIATION;WP3646 HEPATITIS C AND HEPATOCELLULAR CARCINOMA;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP4758 NEPHROTIC SYNDROME;WP2572 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS","http://www.wikipathways.org/instance/WP2858_r116763;http://www.wikipathways.org/instance/WP3646_r116732;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP4758_r108284;http://www.wikipathways.org/instance/WP2572_r119251",{"$nulls":3},"ESTROGEN RESPONSE EARLY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY"]
["O00623","Peroxisome assembly protein 12 OS=Homo sapiens OX=9606 GN=PEX12 PE=1 SV=1","PEX12",0.924683276,0.807251171,"nochange",5159.88,4346.22,2773.51,3592.02,3337.41,4425.32,1.309926734,1.103364762,0.704104533,0.911897762,0.847260514,1.123445695,"cytoplasm","nucleus","K13345","PEX12; peroxin-12","hsa04146 Peroxisome","GO:0000003 reproduction; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006464 cellular protein modification process; GO:0006513 protein monoubiquitination; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009791 post-embryonic development; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015919 peroxisomal membrane transport; GO:0016043 cellular component organization; GO:0016558 protein import into peroxisome matrix; GO:0016567 protein ubiquitination; GO:0017038 protein import; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043574 peroxisomal transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048137 spermatocyte division; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048515 spermatid differentiation; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051301 cell division; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0065002 intracellular protein transmembrane transport; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005779 integral component of peroxisomal membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031231 intrinsic component of peroxisomal membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031903 microbody membrane; GO:0032991 protein-containing complex; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:1990351 transporter complex; GO:1990429 peroxisomal importomer complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG0826","Predicted E3 ubiquitin ligase involved in peroxisome organization",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins;R-HSA-9033241 Peroxisomal protein import;R-HSA-9603798 Class I peroxisomal membrane protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9603798;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","BILE ACID METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM"]
["O00625","Pirin OS=Homo sapiens OX=9606 GN=PIR PE=1 SV=1","PIR",0.671322856,0.000360289,"down",9853.77,8774.79,9329.21,6396.77,6151.97,6219.95,1.265292085,1.126743605,1.19793496,0.821389423,0.789955413,0.798684514,"cytoplasm","K06911",null,null,"GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007586 digestion; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030224 monocyte differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048534 hematopoietic or lymphoid organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903131 mononuclear cell differentiation; GO:1903506 regulation of nucleic acid-templated transcription; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003712 transcription coregulator activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0008127 quercetin 2","3-dioxygenase activity; GO:0016491 oxidoreductase activity; GO:0016701 oxidoreductase activity"," acting on single donors with incorporation of molecular oxygen; GO:0016702 oxidoreductase activity"," acting on single donors with incorporation of molecular oxygen"," incorporation of two atoms of oxygen; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0051213 dioxygenase activity; GO:0140110 transcription regulator activity;","PF05726","PF05726 Pirin C-terminal cupin domain",{"$nulls":5},"Transcription factor","R-HSA-8935690 Digestion;R-HSA-8963743 Digestion and absorption","https://reactome.org/PathwayBrowser/#/R-HSA-8935690;https://reactome.org/PathwayBrowser/#/R-HSA-8963743"]
["O00629","Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1","KPNA4",1.556053574,3.136322E-3,"up",8524.17,9860.17,7812.83,13283.2,14074.7,13406.3,0.763798889,0.883509701,0.70006005,1.190226544,1.261148032,1.201256784,"cytoplasm","K23583","KPNA3_4; importin subunit alpha-4/3","hsa05132 Salmonella infection; hsa03013 Nucleocytoplasmic transport; hsa05207 Chemical carcinogenesis - receptor activation","GO:0000003 reproduction; GO:0000280 nuclear division; GO:0000302 response to reactive oxygen species; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006999 nuclear pore organization; GO:0007049 cell cycle; GO:0007127 meiosis I; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0008104 protein localization; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0019048 modulation by virus of host process; GO:0019054 modulation by virus of host cellular process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035821 modulation of process of another organism; GO:0042221 response to chemical; GO:0042542 response to hydrogen peroxide; GO:0042886 amide transport; GO:0043933 protein-containing complex organization; GO:0044003 modulation by symbiont of host process; GO:0044068 modulation by symbiont of host cellular process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0046677 response to antibiotic; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051321 meiotic cell cycle; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051701 biological process involved in interaction with host; GO:0061982 meiosis I cell cycle process; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0140013 meiotic nuclear division; GO:1901700 response to oxygen-containing compound; GO:1903046 meiotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005048 signal sequence binding; GO:0005102 signaling receptor binding; GO:0005112 Notch binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008139 nuclear localization sequence binding; GO:0017022 myosin binding; GO:0033218 amide binding; GO:0042277 peptide binding;",null,null,"U","KOG0166","Karyopherin (importin) alpha","WP2034 LEPTIN SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2034_r120670",null,"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168276 NS1 Mediated Effects on Host Pathways;R-HSA-5663205 Infectious disease;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1169408;https://reactome.org/PathwayBrowser/#/R-HSA-1169410;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168276;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-913531"]
["O00635","E3 ubiquitin-protein ligase TRIM38 OS=Homo sapiens OX=9606 GN=TRIM38 PE=1 SV=1","TRIM38",1.134128929,0.265319192,"nochange",4970.17,6172.9,6317.22,6586.25,7319.73,5896.24,0.800295525,0.993958807,1.017197178,1.060516321,1.178621086,0.949411084,"nucleus","K12014",null,null,"GO:0002376 immune system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0034097 response to cytokine; GO:0034341 response to interferon-gamma; GO:0042221 response to chemical; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044093 positive regulation of molecular function; GO:0045087 innate immune response; GO:0046596 regulation of viral entry into host cell; GO:0046598 positive regulation of viral entry into host cell; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060333 interferon-gamma-mediated signaling pathway; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0080090 regulation of primary metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;",null,"PF15227; PF00643","PF15227 zinc finger of C3HC4-type"," RING; PF00643 B-box zinc finger","O","KOG2177","Predicted E3 ubiquitin ligase",{"$nulls":3},"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-168256 Immune System;R-HSA-877300 Interferon gamma signaling;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-877300;https://reactome.org/PathwayBrowser/#/R-HSA-913531"]
["O00716","Transcription factor E2F3 OS=Homo sapiens OX=9606 GN=E2F3 PE=1 SV=1","E2F3",1.074046346,0.723861582,"nochange",1082.12,931.69,1980.04,1112.24,1853.64,1323.7,0.783820229,0.67485812,1.434217468,0.805637278,1.342661192,0.958805712,"nucleus","K06620","E2F3; transcription factor E2F3","hsa05160 Hepatitis C; hsa05224 Breast cancer; hsa05161 Hepatitis B; hsa05166 Human T-cell leukemia virus 1 infection; hsa05200 Pathways in cancer; hsa05169 Epstein-Barr virus infection; hsa05225 Hepatocellular carcinoma; hsa04110 Cell cycle; hsa05226 Gastric cancer; hsa05206 MicroRNAs in cancer; hsa04934 Cushing syndrome; hsa05219 Bladder cancer; hsa05214 Glioma; hsa01522 Endocrine resistance; hsa05215 Prostate cancer; hsa05223 Non-small cell lung cancer; hsa05212 Pancreatic cancer; hsa05222 Small cell lung cancer; hsa05163 Human cytomegalovirus infection; hsa05220 Chronic myeloid leukemia; hsa04218 Cellular senescence; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa05218 Melanoma","GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010660 regulation of muscle cell apoptotic process; GO:0010661 positive regulation of muscle cell apoptotic process; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034391 regulation of smooth muscle cell apoptotic process; GO:0034393 positive regulation of smooth muscle cell apoptotic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042127 regulation of cell population proliferation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070344 regulation of fat cell proliferation; GO:0070345 negative regulation of fat cell proliferation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905459 regulation of vascular associated smooth muscle cell apoptotic process; GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF02319; PF16421","PF02319 E2F/DP family winged-helix DNA-binding domain; PF16421 E2F transcription factor CC-MB domain","K","KOG2577","Transcription factor E2F/dimerization partner (TDP)","WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP4262 BREAST CANCER PATHWAY;WP179 CELL CYCLE;WP45 G1 TO S CELL CYCLE CONTROL;WP4685 MELANOMA;WP2249 METASTATIC BRAIN TUMOR;WP4758 NEPHROTIC SYNDROME;WP4255 NONSMALL CELL LUNG CANCER;WP4263 PANCREATIC ADENOCARCINOMA PATHWAY;WP2446 RETINOBLASTOMA GENE IN CANCER;WP4658 SMALL CELL LUNG CANCER","http://www.wikipathways.org/instance/WP23_r120701;http://www.wikipathways.org/instance/WP4262_r108103;http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP45_r106424;http://www.wikipathways.org/instance/WP4685_r119240;http://www.wikipathways.org/instance/WP2249_r107453;http://www.wikipathways.org/instance/WP4758_r108284;http://www.wikipathways.org/instance/WP4255_r119279;http://www.wikipathways.org/instance/WP4263_r105482;http://www.wikipathways.org/instance/WP2446_r116593;http://www.wikipathways.org/instance/WP4658_r119261","Transcription factor","R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-1912408 Pre-NOTCH Transcription and Translation;R-HSA-1912422 Pre-NOTCH Expression and Processing;R-HSA-2262752 Cellular responses to stress;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559583 Cellular Senescence;R-HSA-2559585 Oncogene Induced Senescence;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-68911 G2 Phase;R-HSA-69231 Cyclin D associated events in G1;R-HSA-69236 G1 Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects;R-HSA-9661069 Defective binding of RB1 mutants to E2F1","(E2F2"," E2F3);R-HSA-9675126 Diseases of mitotic cell cycle;R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects","https://reactome.org/PathwayBrowser/#/R-HSA-157118;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1912408;https://reactome.org/PathwayBrowser/#/R-HSA-1912422;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2559580;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-2559585;https://reactome.org/PathwayBrowser/#/R-HSA-453274;https://reactome.org/PathwayBrowser/#/R-HSA-453279;https://reactome.org/PathwayBrowser/#/R-HSA-68911;https://reactome.org/PathwayBrowser/#/R-HSA-69231;https://reactome.org/PathwayBrowser/#/R-HSA-69236;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9659787;https://reactome.org/PathwayBrowser/#/R-HSA-9661069;https://reactome.org/PathwayBrowser/#/R-HSA-9675126;https://reactome.org/PathwayBrowser/#/R-HSA-9687139","G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O00743","Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1","PPP6C",0.833983355,0.007578407,"down",37617.1,35111.4,33960.2,29074.5,30876,29026.1,1.153513679,1.076677367,1.041376269,0.891558186,0.94680048,0.890074019,"extracellular","K15498",null,null,"GO:0000082 G1/S transition of mitotic cell cycle; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009790 embryo development; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016311 dephosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030588 pseudocleavage; GO:0030590 first cell cycle pseudocleavage; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0036211 protein modification process; GO:0040001 establishment of mitotic spindle localization; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045936 negative regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051293 establishment of spindle localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090114 COPII-coated vesicle budding; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process;","GO:0000235 astral microtubule; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005818 aster; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0005881 cytoplasmic microtubule; GO:0005938 cell cortex; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region;","GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004722 protein serine/threonine phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00149","PF00149 Calcineurin-like phosphoesterase","DT","KOG0373","Serine/threonine specific protein phosphatase involved in cell cycle control"," PP2A-related",{"$nulls":3},"R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-171319 Telomere Extension By Telomerase;R-HSA-180786 Extension of Telomeres;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-73886 Chromosome Maintenance;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-157579;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-171319;https://reactome.org/PathwayBrowser/#/R-HSA-180786;https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73886;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["O00746","Nucleoside diphosphate kinase"," mitochondrial OS=Homo sapiens OX=9606 GN=NME4 PE=1 SV=1","NME4",0.875250042,0.139619393,"nochange",9512.62,9954.31,8548.31,9092.95,7941.26,7486.13,1.086420289,1.136864959,0.97628807,1.038490486,0.906957913,0.854978283,"mitochondria","K00940","ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]","hsa00983 Drug metabolism - other enzymes; hsa00240 Pyrimidine metabolism; hsa01240 Biosynthesis of cofactors; hsa01232 Nucleotide metabolism; hsa00230 Purine metabolism; hsa01100 Metabolic pathways","GO:0006139 nucleobase-containing compound metabolic process; GO:0006165 nucleoside diphosphate phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006869 lipid transport; GO:0008152 metabolic process; GO:0009116 nucleoside metabolic process; GO:0009117 nucleotide metabolic process; GO:0009132 nucleoside diphosphate metabolic process; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0010941 regulation of cell death; GO:0015949 nucleobase-containing small molecule interconversion; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0033036 macromolecule localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042981 regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0046939 nucleotide phosphorylation; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901657 glycosyl compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005758 mitochondrial intermembrane space; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004550 nucleoside diphosphate kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016776 phosphotransferase activity"," phosphate group as acceptor; GO:0019205 nucleobase-containing compound kinase activity; GO:0019899 enzyme binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0051020 GTPase binding; GO:1901611 phosphatidylglycerol binding; GO:1901612 cardiolipin binding;","PF00334","PF00334 Nucleoside diphosphate kinase","F","KOG0888","Nucleoside diphosphate kinase","WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-499943 Interconversion of nucleotide di- and triphosphates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-499943","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O00748","Cocaine esterase OS=Homo sapiens OX=9606 GN=CES2 PE=1 SV=1","CES2",0.541069312,0.021468923,"nochange",3553.36,2287.21,3042.34,1733.89,1785.02,1287.36,1.5574461,1.002489557,1.333464824,0.759968092,0.782378492,0.564252936,"plasma membrane","K03927","CES2; carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]","hsa00983 Drug metabolism - other enzymes","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001941 postsynaptic membrane organization; GO:0006066 alcohol metabolic process; GO:0006082 organic acid metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006690 icosanoid metabolic process; GO:0006692 prostanoid metabolic process; GO:0006693 prostaglandin metabolic process; GO:0006694 steroid biosynthetic process; GO:0006695 cholesterol biosynthetic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006869 lipid transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0007155 cell adhesion; GO:0007158 neuron cell-cell adhesion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007416 synapse assembly; GO:0007610 behavior; GO:0007617 mating behavior; GO:0007618 mating; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008039 synaptic target recognition; GO:0008045 motor neuron axon guidance; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008203 cholesterol metabolic process; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010876 lipid localization; GO:0015850 organic hydroxy compound transport; GO:0015918 sterol transport; GO:0016043 cellular component organization; GO:0016125 sterol metabolic process; GO:0016126 sterol biosynthetic process; GO:0016192 vesicle-mediated transport; GO:0016201 synaptic target inhibition; GO:0016482 cytosolic transport; GO:0019098 reproductive behavior; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030301 cholesterol transport; GO:0030431 sleep; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0032365 intracellular lipid transport; GO:0032366 intracellular sterol transport; GO:0032367 intracellular cholesterol transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032787 monocarboxylic acid metabolic process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033559 unsaturated fatty acid metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0036465 synaptic vesicle recycling; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0043436 oxoacid metabolic process; GO:0044085 cellular component biogenesis; GO:0044091 membrane biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0046165 alcohol biosynthetic process; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048488 synaptic vesicle endocytosis; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0050919 negative chemotaxis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051791 medium-chain fatty acid metabolic process; GO:0060179 male mating behavior; GO:0060429 epithelium development; GO:0061024 membrane organization; GO:0061564 axon development; GO:0065007 biological regulation; GO:0070085 glycosylation; GO:0070887 cellular response to chemical stimulus; GO:0071466 cellular response to xenobiotic stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071709 membrane assembly; GO:0071840 cellular component organization or biogenesis; GO:0090119 vesicle-mediated cholesterol transport; GO:0090122 cholesterol ester hydrolysis involved in cholesterol transport; GO:0097090 presynaptic membrane organization; GO:0097104 postsynaptic membrane assembly; GO:0097105 presynaptic membrane assembly; GO:0097485 neuron projection guidance; GO:0098542 defense response to other organism; GO:0098609 cell-cell adhesion; GO:0098657 import into cell; GO:0099003 vesicle-mediated transport in synapse; GO:0099054 presynapse assembly; GO:0099068 postsynapse assembly; GO:0099172 presynapse organization; GO:0099173 postsynapse organization; GO:0099177 regulation of trans-synaptic signaling; GO:0099504 synaptic vesicle cycle; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1902652 secondary alcohol metabolic process; GO:1902653 secondary alcohol biosynthetic process;","GO:0005576 extracellular region; GO:0005604 basement membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031012 extracellular matrix; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0062023 collagen-containing extracellular matrix; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0003824 catalytic activity; GO:0004771 sterol esterase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016298 lipase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0042043 neurexin family protein binding; GO:0047619 acylcarnitine hydrolase activity; GO:0052689 carboxylic ester hydrolase activity;","PF00135","PF00135 Carboxylesterase family","R","KOG1516","Carboxylesterase and related proteins","WP1601 FLUOROPYRIMIDINE ACTIVITY;WP229 IRINOTECAN PATHWAY;WP2884 NRF2 PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP136 PHASE I BIOTRANSFORMATIONS NON P450","http://www.wikipathways.org/instance/WP1601_r120496;http://www.wikipathways.org/instance/WP229_r116612;http://www.wikipathways.org/instance/WP2884_r106658;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP136_r118346",null,"R-HSA-1430728 Metabolism;R-HSA-211859 Biological oxidations;R-HSA-211945 Phase I - Functionalization of compounds;R-HSA-9748784 Drug ADME;R-HSA-9749641 Aspirin ADME","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-211945;https://reactome.org/PathwayBrowser/#/R-HSA-9748784;https://reactome.org/PathwayBrowser/#/R-HSA-9749641"]
["O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2","PIK3C2B",1.090857748,0.90920549,"nochange",1359.9,1197.59,742.933,617.932,1448.06,1534.3,1.182399215,1.041274708,0.645961759,0.5372765,1.259052142,1.334035676,"nucleus","K00923","PIK3C2; phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]","hsa05132 Salmonella infection; hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003008 system process; GO:0003012 muscle system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006936 muscle contraction; GO:0006939 smooth muscle contraction; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007275 multicellular organism development; GO:0008015 blood circulation; GO:0008152 metabolic process; GO:0008286 insulin receptor signaling pathway; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0014065 phosphatidylinositol 3-kinase signaling; GO:0014829 vascular associated smooth muscle contraction; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0019637 organophosphate metabolic process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030258 lipid modification; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0035150 regulation of tube size; GO:0035296 regulation of tube diameter; GO:0035556 intracellular signal transduction; GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process; GO:0038127 ERBB signaling pathway; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042221 response to chemical; GO:0042310 vasoconstriction; GO:0043277 apoptotic cell clearance; GO:0043434 response to peptide hormone; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0043536 positive regulation of blood vessel endothelial cell migration; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045765 regulation of angiogenesis; GO:0045766 positive regulation of angiogenesis; GO:0045807 positive regulation of endocytosis; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046834 lipid phosphorylation; GO:0046854 phosphatidylinositol phosphate biosynthetic process; GO:0046903 secretion; GO:0048008 platelet-derived growth factor receptor signaling pathway; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048268 clathrin coat assembly; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060100 positive regulation of phagocytosis"," engulfment; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090049 regulation of cell migration involved in sprouting angiogenesis; GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis; GO:0090066 regulation of anatomical structure size; GO:0090382 phagosome maturation; GO:0090386 phagosome maturation involved in apoptotic cell clearance; GO:0090407 organophosphate biosynthetic process; GO:0097746 blood vessel diameter maintenance; GO:0098657 import into cell; GO:1901342 regulation of vasculature development; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903670 regulation of sprouting angiogenesis; GO:1903672 positive regulation of sprouting angiogenesis; GO:1904018 positive regulation of vasculature development; GO:1905153 regulation of membrane invagination; GO:1905155 positive regulation of membrane invagination; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005942 phosphatidylinositol 3-kinase complex; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030139 endocytic vesicle; GO:0031090 organelle membrane; GO:0031143 pseudopodium; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032009 early phagosome; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045335 phagocytic vesicle; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0016301 kinase activity; GO:0016303 1-phosphatidylinositol-3-kinase activity; GO:0016307 phosphatidylinositol phosphate kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0035004 phosphatidylinositol 3-kinase activity; GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0051020 GTPase binding; GO:0052742 phosphatidylinositol kinase activity;","PF00794; PF00792; PF00787; PF00168","PF00794 PI3-kinase family"," ras-binding domain; PF00792 Phosphoinositide 3-kinase C2; PF00787 PX domain; PF00168 C2 domain","T","KOG0905","Phosphoinositide 3-kinase","WP710 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT;WP437 EGFEGFR SIGNALING PATHWAY;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP2261 GLIOBLASTOMA SIGNALING PATHWAYS;WP4787 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES;WP4971 PHOSPHOINOSITIDES METABOLISM;WP51 REGULATION OF ACTIN CYTOSKELETON;WP26 S1P RECEPTOR SIGNAL TRANSDUCTION","http://www.wikipathways.org/instance/WP710_r116542;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP2261_r118379;http://www.wikipathways.org/instance/WP4787_r118872;http://www.wikipathways.org/instance/WP4971_r112223;http://www.wikipathways.org/instance/WP51_r116716;http://www.wikipathways.org/instance/WP26_r118660",null,"R-HSA-1430728 Metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["O00754","Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3","MAN2B1",0.910204451,0.076466388,"nochange",41990.1,43393.4,39639.4,38280.7,39665,35850.7,1.054942377,1.090198321,0.995884336,0.961748904,0.9965275,0.900698562,"extracellular","K12311","MAN2B1; lysosomal alpha-mannosidase [EC:3.2.1.24]","hsa04142 Lysosome; hsa00511 Other glycan degradation","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003008 system process; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006013 mannose metabolic process; GO:0006464 cellular protein modification process; GO:0006517 protein deglycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0007610 behavior; GO:0007611 learning or memory; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009311 oligosaccharide metabolic process; GO:0009313 oligosaccharide catabolic process; GO:0009987 cellular process; GO:0016052 carbohydrate catabolic process; GO:0016192 vesicle-mediated transport; GO:0019318 hexose metabolic process; GO:0019538 protein metabolic process; GO:0032501 multicellular organismal process; GO:0032940 secretion by cell; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0042582 azurophil granule; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0003824 catalytic activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0004559 alpha-mannosidase activity; GO:0004571 mannosyl-oligosaccharide 1","2-alpha-mannosidase activity; GO:0005488 binding; GO:0005537 mannose binding; GO:0015923 mannosidase activity; GO:0015924 mannosyl-oligosaccharide mannosidase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0030246 carbohydrate binding; GO:0036094 small molecule binding; GO:0048029 monosaccharide binding;","PF01074; PF09261; PF07748; PF17677","PF01074 Glycosyl hydrolases family 38 N-terminal domain; PF09261 Alpha mannosidase middle domain; PF07748 Glycosyl hydrolases family 38 C-terminal domain; PF17677 Glycosyl hydrolases family 38 C-terminal beta sandwich domain","G","KOG1959","Glycosyl hydrolase"," family 38 - alpha-mannosidase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation;R-HSA-71387 Metabolism of carbohydrates;R-HSA-8853383 Lysosomal oligosaccharide catabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-71387;https://reactome.org/PathwayBrowser/#/R-HSA-8853383"]
["O00762","Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1","UBE2C",3.09829426,{"v":5.71912e-05,"d":"5.72E-05"},"up",9041.92,10559.5,10392.6,32781.2,31472.1,28677,0.441340818,0.515414688,0.507268212,1.600067424,1.536169572,1.399739287,"cytoplasm","K06688","UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]","hsa04120 Ubiquitin mediated proteolysis","GO:0000209 protein polyubiquitination; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007088 regulation of mitotic nuclear division; GO:0007096 regulation of exit from mitosis; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010458 exit from mitosis; GO:0010498 proteasomal protein catabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010965 regulation of mitotic sister chromatid separation; GO:0010992 ubiquitin recycling; GO:0010994 free ubiquitin chain polymerization; GO:0016043 cellular component organization; GO:0016567 protein ubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0019941 modification-dependent protein catabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030163 protein catabolic process; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031536 positive regulation of exit from mitosis; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032446 protein modification by small protein conjugation; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0042592 homeostatic process; GO:0043085 positive regulation of catalytic activity; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0045732 positive regulation of protein catabolic process; GO:0045787 positive regulation of cell cycle; GO:0045840 positive regulation of mitotic nuclear division; GO:0045842 positive regulation of mitotic metaphase/anaphase transition; GO:0045862 positive regulation of proteolysis; GO:0045931 positive regulation of mitotic cell cycle; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051258 protein polymerization; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051438 regulation of ubiquitin-protein transferase activity; GO:0051443 positive regulation of ubiquitin-protein transferase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051984 positive regulation of chromosome segregation; GO:0060255 regulation of macromolecule metabolic process; GO:0062033 positive regulation of mitotic sister chromatid segregation; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070647 protein modification by small protein conjugation or removal; GO:0070936 protein K48-linked ubiquitination; GO:0070979 protein K11-linked ubiquitination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0140014 mitotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901970 positive regulation of mitotic sister chromatid separation; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle; GO:1903047 mitotic cell cycle process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1904666 regulation of ubiquitin protein ligase activity; GO:1904668 positive regulation of ubiquitin protein ligase activity; GO:1905818 regulation of chromosome separation; GO:1905820 positive regulation of chromosome separation; GO:2001252 positive regulation of chromosome organization;","GO:0000151 ubiquitin ligase complex; GO:0000152 nuclear ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005680 anaphase-promoting complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0061630 ubiquitin protein ligase activity; GO:0061631 ubiquitin conjugating enzyme activity; GO:0061650 ubiquitin-like protein conjugating enzyme activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00179","PF00179 Ubiquitin-conjugating enzyme","O","KOG0421","Ubiquitin-protein ligase","WP2361 GASTRIC CANCER NETWORK 1;WP2363 GASTRIC CANCER NETWORK 2","http://www.wikipathways.org/instance/WP2361_r117731;http://www.wikipathways.org/instance/WP2363_r117737",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176412 Phosphorylation of the APC/C;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP);R-HSA-2559583 Cellular Senescence;R-HSA-392499 Metabolism of proteins;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-597592 Post-translational protein modification;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8852135 Protein ubiquitination;R-HSA-8853884 Transcriptional Regulation by VENTX;R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9675126 Diseases of mitotic cell cycle;R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects;R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation",null,"G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O00764","Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1","PDXK",0.905540342,0.04182681,"nochange",39234.5,37914.1,37550.1,36785,33272,33807.3,1.077067024,1.040819352,1.03082681,1.009823255,0.913384242,0.928079318,"cytoplasm","K00868","pdxK; pyridoxine kinase [EC:2.7.1.35]","hsa01240 Biosynthesis of cofactors; hsa00750 Vitamin B6 metabolism; hsa01100 Metabolic pathways","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006081 cellular aldehyde metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009058 biosynthetic process; GO:0009110 vitamin biosynthetic process; GO:0009314 response to radiation; GO:0009443 pyridoxal 5'-phosphate salvage; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010165 response to X-ray; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0014075 response to amine; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0017085 response to insecticide; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0031667 response to nutrient levels; GO:0032094 response to food; GO:0032570 response to progesterone; GO:0032940 secretion by cell; GO:0033993 response to lipid; GO:0034284 response to monosaccharide; GO:0034641 cellular nitrogen compound metabolic process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042364 water-soluble vitamin biosynthetic process; GO:0042816 vitamin B6 metabolic process; GO:0042819 vitamin B6 biosynthetic process; GO:0042822 pyridoxal phosphate metabolic process; GO:0042823 pyridoxal phosphate biosynthetic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043094 cellular metabolic compound salvage; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044237 cellular metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046184 aldehyde biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071326 cellular response to monosaccharide stimulus; GO:0071704 organic substance metabolic process; GO:0072524 pyridine-containing compound metabolic process; GO:0072525 pyridine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1901654 response to ketone; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035580 specific granule lumen; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0000166 nucleotide binding; GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008270 zinc ion binding; GO:0008478 pyridoxal kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019842 vitamin binding; GO:0030170 pyridoxal phosphate binding; GO:0030554 adenyl nucleotide binding; GO:0030955 potassium ion binding; GO:0031402 sodium ion binding; GO:0031403 lithium ion binding; GO:0031420 alkali metal ion binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046983 protein dimerization activity; GO:0070279 vitamin B6 binding; GO:0070280 pyridoxal binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"H","KOG2599","Pyridoxal/pyridoxine/pyridoxamine kinase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-196849 Metabolism of water-soluble vitamins and cofactors;R-HSA-196854 Metabolism of vitamins and cofactors;R-HSA-6798695 Neutrophil degranulation;R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-196849;https://reactome.org/PathwayBrowser/#/R-HSA-196854;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-964975"]
["O00767","Stearoyl-CoA desaturase OS=Homo sapiens OX=9606 GN=SCD PE=1 SV=2","SCD",0.357523156,0.00809659,"down",32071.9,44929.2,28630.1,10565.5,10235.2,16964.9,1.341950448,1.879924796,1.197938866,0.442080995,0.428260603,0.709844292,"cytoplasm","K00507","SCD; stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1]","hsa04936 Alcoholic liver disease; hsa03320 PPAR signaling pathway; hsa01040 Biosynthesis of unsaturated fatty acids; hsa01212 Fatty acid metabolism; hsa04152 AMPK signaling pathway; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000278 mitotic cell cycle; GO:0000281 mitotic cytokinesis; GO:0000910 cytokinesis; GO:0001101 response to acid chemical; GO:0001676 long-chain fatty acid metabolic process; GO:0002376 immune system process; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006636 unsaturated fatty acid biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006638 neutral lipid metabolic process; GO:0006639 acylglycerol metabolic process; GO:0006641 triglyceride metabolic process; GO:0006723 cuticle hydrocarbon biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007272 ensheathment of neurons; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007584 response to nutrient; GO:0007610 behavior; GO:0007617 mating behavior; GO:0007618 mating; GO:0007619 courtship behavior; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008361 regulation of cell size; GO:0008366 axon ensheathment; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009743 response to carbohydrate; GO:0009744 response to sucrose; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010506 regulation of autophagy; GO:0010817 regulation of hormone levels; GO:0010872 regulation of cholesterol esterification; GO:0010873 positive regulation of cholesterol esterification; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0018130 heterocycle biosynthetic process; GO:0019098 reproductive behavior; GO:0019216 regulation of lipid metabolic process; GO:0019218 regulation of steroid metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019748 secondary metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0030104 water homeostasis; GO:0030154 cell differentiation; GO:0030258 lipid modification; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0031670 cellular response to nutrient; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032787 monocarboxylic acid metabolic process; GO:0033500 carbohydrate homeostasis; GO:0033559 unsaturated fatty acid metabolic process; GO:0033561 regulation of water loss via skin; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0033993 response to lipid; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034285 response to disaccharide; GO:0034433 steroid esterification; GO:0034434 sterol esterification; GO:0034435 cholesterol esterification; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035337 fatty-acyl-CoA metabolic process; GO:0035383 thioester metabolic process; GO:0035384 thioester biosynthetic process; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0042221 response to chemical; GO:0042335 cuticle development; GO:0042445 hormone metabolic process; GO:0042446 hormone biosynthetic process; GO:0042552 myelination; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042594 response to starvation; GO:0042742 defense response to bacterium; GO:0042759 long-chain fatty acid biosynthetic process; GO:0042810 pheromone metabolic process; GO:0042811 pheromone biosynthetic process; GO:0043207 response to external biotic stimulus; GO:0043436 oxoacid metabolic process; GO:0043588 skin development; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044550 secondary metabolite biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045087 innate immune response; GO:0045444 fat cell differentiation; GO:0045540 regulation of cholesterol biosynthetic process; GO:0045570 regulation of imaginal disc growth; GO:0045572 positive regulation of imaginal disc growth; GO:0045793 positive regulation of cell size; GO:0045834 positive regulation of lipid metabolic process; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045940 positive regulation of steroid metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046620 regulation of organ growth; GO:0046622 positive regulation of organ growth; GO:0046890 regulation of lipid biosynthetic process; GO:0046949 fatty-acyl-CoA biosynthetic process; GO:0048047 mating behavior"," sex discrimination; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048731 system development; GO:0048732 gland development; GO:0048733 sebaceous gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050810 regulation of steroid biosynthetic process; GO:0050830 defense response to Gram-positive bacterium; GO:0050872 white fat cell differentiation; GO:0050873 brown fat cell differentiation; GO:0050878 regulation of body fluid levels; GO:0050891 multicellular organismal water homeostasis; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051301 cell division; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0055088 lipid homeostasis; GO:0055090 acylglycerol homeostasis; GO:0060179 male mating behavior; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0062012 regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070328 triglyceride homeostasis; GO:0070542 response to fatty acid; GO:0070887 cellular response to chemical stimulus; GO:0071496 cellular response to external stimulus; GO:0071616 acyl-CoA biosynthetic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090181 regulation of cholesterol metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0098542 defense response to other organism; GO:0106118 regulation of sterol biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound; GO:1902930 regulation of alcohol biosynthetic process; GO:1903047 mitotic cell cycle process; GO:1903699 tarsal gland development; GO:1903964 monounsaturated fatty acid metabolic process; GO:1903966 monounsaturated fatty acid biosynthetic process; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0004768 stearoyl-CoA 9-desaturase activity; GO:0005488 binding; GO:0005506 iron ion binding; GO:0016215 acyl-CoA desaturase activity; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016717 oxidoreductase activity"," acting on paired donors"," with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; GO:0032896 palmitoyl-CoA 9-desaturase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding;",null,null,"I","KOG1600","Fatty acid desaturase","WP236 ADIPOGENESIS;WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP4718 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCHRUSSELL PATHWAYS;WP357 FATTY ACID BIOSYNTHESIS;WP2874 LIVER X RECEPTOR PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP4724 OMEGA9 FATTY ACID SYNTHESIS;WP3942 PPAR SIGNALING PATHWAY;WP2011 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS;WP1982 STEROL REGULATORY ELEMENTBINDING PROTEINS SREBP SIGNALING","http://www.wikipathways.org/instance/WP236_r105873;http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP4718_r119764;http://www.wikipathways.org/instance/WP357_r117722;http://www.wikipathways.org/instance/WP2874_r116465;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP4724_r117812;http://www.wikipathways.org/instance/WP3942_r106517;http://www.wikipathways.org/instance/WP2011_r118441;http://www.wikipathways.org/instance/WP1982_r116442",null,"R-HSA-1430728 Metabolism;R-HSA-162582 Signal Transduction;R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF);R-HSA-2426168 Activation of gene expression by SREBF (SREBP);R-HSA-556833 Metabolism of lipids;R-HSA-75105 Fatty acyl-CoA biosynthesis;R-HSA-8957322 Metabolism of steroids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9024446 NR1H2 and NR1H3-mediated signaling;R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1655829;https://reactome.org/PathwayBrowser/#/R-HSA-2426168;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-75105;https://reactome.org/PathwayBrowser/#/R-HSA-8957322;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9024446;https://reactome.org/PathwayBrowser/#/R-HSA-9029558","ANDROGEN RESPONSE;CHOLESTEROL HOMEOSTASIS;MTORC1 SIGNALING;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_CHOLESTEROL_HOMEOSTASIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["O14497","AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3","ARID1A",1.34178325,{"v":6.66934e-05,"d":"6.67E-05"},"up",25904.1,26953.1,26528.2,35241.1,36381.3,34895.6,0.836050336,0.869906629,0.856193055,1.137400392,1.174200149,1.126249439,"cytoplasm","K11653","ARID1; AT-rich interactive domain-containing protein 1","hsa05225 Hepatocellular carcinoma; hsa04714 Thermogenesis","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001568 blood vessel development; GO:0001654 eye development; GO:0001704 formation of primary germ layer; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001890 placenta development; GO:0001944 vasculature development; GO:0002009 morphogenesis of an epithelium; GO:0002072 optic cup morphogenesis involved in camera-type eye development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003205 cardiac chamber development; GO:0003408 optic cup formation involved in camera-type eye development; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006337 nucleosome disassembly; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006810 transport; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007379 segment specification; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007406 negative regulation of neuroblast proliferation; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007447 imaginal disc pattern formation; GO:0007450 dorsal/ventral pattern formation"," imaginal disc; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007507 heart development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007565 female pregnancy; GO:0007566 embryo implantation; GO:0007591 molting cycle"," chitin-based cuticle; GO:0007593 chitin-based cuticle sclerotization; GO:0008285 negative regulation of cell population proliferation; GO:0008586 imaginal disc-derived wing vein morphogenesis; GO:0008587 imaginal disc-derived wing margin morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0014016 neuroblast differentiation; GO:0014017 neuroblast fate commitment; GO:0014020 primary neural tube formation; GO:0014070 response to organic cyclic compound; GO:0014706 striated muscle tissue development; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0016331 morphogenesis of embryonic epithelium; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019827 stem cell population maintenance; GO:0021700 developmental maturation; GO:0021915 neural tube development; GO:0022008 neurogenesis; GO:0022404 molting cycle process; GO:0022411 cellular component disassembly; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030520 intracellular estrogen receptor signaling pathway; GO:0030521 androgen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0030900 forebrain development; GO:0031076 embryonic camera-type eye development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031498 chromatin disassembly; GO:0031958 corticosteroid receptor signaling pathway; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032870 cellular response to hormone stimulus; GO:0032984 protein-containing complex disassembly; GO:0032986 protein-DNA complex disassembly; GO:0033993 response to lipid; GO:0034728 nucleosome organization; GO:0035051 cardiocyte differentiation; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035148 tube formation; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035222 wing disc pattern formation; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035295 tube development; GO:0040029 regulation of gene expression"," epigenetic; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042303 molting cycle; GO:0042335 cuticle development; GO:0042692 muscle cell differentiation; GO:0042766 nucleosome mobilization; GO:0042921 glucocorticoid receptor signaling pathway; GO:0043009 chordate embryonic development; GO:0043010 camera-type eye development; GO:0043401 steroid hormone mediated signaling pathway; GO:0043473 pigmentation; GO:0043933 protein-containing complex organization; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046530 photoreceptor cell differentiation; GO:0048048 embryonic eye morphogenesis; GO:0048066 developmental pigmentation; GO:0048067 cuticle pigmentation; GO:0048085 adult chitin-containing cuticle pigmentation; GO:0048190 wing disc dorsal/ventral pattern formation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048562 embryonic organ morphogenesis; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048568 embryonic organ development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048593 camera-type eye morphogenesis; GO:0048596 embryonic camera-type eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048738 cardiac muscle tissue development; GO:0048856 anatomical structure development; GO:0048863 stem cell differentiation; GO:0048865 stem cell fate commitment; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0055007 cardiac muscle cell differentiation; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060429 epithelium development; GO:0060537 muscle tissue development; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0060674 placenta blood vessel development; GO:0060900 embryonic camera-type eye formation; GO:0061061 muscle structure development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072091 regulation of stem cell proliferation; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090596 sensory organ morphogenesis; GO:0098727 maintenance of cell number; GO:0198738 cell-cell signaling by wnt; GO:1901184 regulation of ERBB signaling pathway; GO:1901998 toxin transport; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902692 regulation of neuroblast proliferation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000647 negative regulation of stem cell proliferation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016514 SWI/SNF complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035060 brahma complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0071564 npBAF complex; GO:0071565 nBAF complex; GO:0071944 cell periphery; GO:1902494 catalytic complex; GO:1904949 ATPase complex;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016922 nuclear receptor binding; GO:0051427 hormone receptor binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF01388","PF01388 ARID/BRIGHT DNA binding domain","B","KOG2510","SWI-SNF chromatin-remodeling complex protein","WP3651 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA;WP4321 THERMOGENESIS;WP4204 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1","http://www.wikipathways.org/instance/WP3651_r116547;http://www.wikipathways.org/instance/WP4321_r106178;http://www.wikipathways.org/instance/WP4204_r108297","Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-3214858 RMTs methylate histone arginines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3214858;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8939243"]
["O14519","Cyclin-dependent kinase 2-associated protein 1 OS=Homo sapiens OX=9606 GN=CDK2AP1 PE=1 SV=1","CDK2AP1",1.057945279,0.649380742,"nochange",7202.86,5821.18,6128.34,7966.23,6193.25,6102.69,1.096477316,0.886146867,0.932905234,1.212683641,0.942786357,0.929000585,"mitochondria",{"$nulls":3},"GO:0001701 in utero embryonic development; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060323 head morphogenesis; GO:0060324 face development; GO:0060325 face morphogenesis; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0070182 DNA polymerase binding;",null,null,"TD","KOG4713","Cyclin-dependent kinase 2-associated protein"]
["O14521","Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"," mitochondrial OS=Homo sapiens OX=9606 GN=SDHD PE=1 SV=1","SDHD",1.151477086,0.058106051,"nochange",16495.4,16332.1,17007.1,18058.4,21132.7,18192.3,0.923095003,0.913956612,0.95173012,1.010561659,1.182601802,1.018054804,"mitochondria","K00237","SDHD; succinate dehydrogenase (ubiquinone) membrane anchor subunit","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa00020 Citrate cycle (TCA cycle); hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04714 Thermogenesis; hsa01200 Carbon metabolism; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0001666 response to hypoxia; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006099 tricarboxylic acid cycle; GO:0006101 citrate metabolic process; GO:0006119 oxidative phosphorylation; GO:0006121 mitochondrial electron transport"," succinate to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0008152 metabolic process; GO:0009060 aerobic respiration; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016310 phosphorylation; GO:0016999 antibiotic metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032879 regulation of localization; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0050433 regulation of catecholamine secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051716 cellular response to stimulus; GO:0051952 regulation of amine transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0070887 cellular response to chemical stimulus; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071704 organic substance metabolic process; GO:0072350 tricarboxylic acid metabolic process; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1903530 regulation of secretion by cell;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005749 mitochondrial respiratory chain complex II"," succinate dehydrogenase complex (ubiquinone); GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045257 succinate dehydrogenase complex (ubiquinone); GO:0045273 respiratory chain complex II; GO:0045281 succinate dehydrogenase complex; GO:0045283 fumarate reductase complex; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0000104 succinate dehydrogenase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0008177 succinate dehydrogenase (ubiquinone) activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016627 oxidoreductase activity"," acting on the CH-CH group of donors; GO:0016635 oxidoreductase activity"," acting on the CH-CH group of donors"," quinone or related compound as acceptor; GO:0020037 heme binding; GO:0046906 tetrapyrrole binding; GO:0048038 quinone binding; GO:0048039 ubiquinone binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"CU","KOG4097","Succinate dehydrogenase membrane anchor subunit and related proteins","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4920 MITOCHONDRIAL COMPLEX II ASSEMBLY;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP78 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4920_r117791;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP78_r119082",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-71403 Citric acid cycle (TCA cycle);R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-71403;https://reactome.org/PathwayBrowser/#/R-HSA-71406","FATTY ACID METABOLISM;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O14526","F-BAR domain only protein 1 OS=Homo sapiens OX=9606 GN=FCHO1 PE=1 SV=2","FCHO1",0.546653605,2.15227E-3,"down",6710.65,7435.3,7454.31,3346.24,4127.97,4333.65,1.205212984,1.335357991,1.338772131,0.600974853,0.741371259,0.778310782,"nucleus","K20042",null,null,"GO:0003002 regionalization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006810 transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030509 BMP signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0042221 response to chemical; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0048268 clathrin coat assembly; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071772 response to BMP; GO:0071773 cellular response to BMP stimulus; GO:0071840 cellular component organization or biogenesis; GO:0072583 clathrin-dependent endocytosis; GO:0080090 regulation of primary metabolic process; GO:0098657 import into cell; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005905 clathrin-coated pit; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0005488 binding; GO:0035612 AP-2 adaptor complex binding; GO:0044877 protein-containing complex binding;","PF10291","PF10291 Muniscin C-terminal mu homology domain","D","KOG2398","Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP)",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828"]
["O14530","Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2","TXNDC9",1.181216332,0.136189837,"nochange",5964.43,7133.27,8070.37,7988.15,8171.16,8844.76,0.775068689,0.926957685,1.048732417,1.038048052,1.061829926,1.149363231,"cytoplasm",{"$nulls":3},"GO:0000226 microtubule cytoskeleton organization; GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0008152 metabolic process; GO:0008616 queuosine biosynthetic process; GO:0009058 biosynthetic process; GO:0009116 nucleoside metabolic process; GO:0009119 ribonucleoside metabolic process; GO:0009163 nucleoside biosynthetic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042455 ribonucleoside biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046116 queuosine metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901657 glycosyl compound metabolic process; GO:1901659 glycosyl compound biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0030496 midbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle;",null,"PF00085","PF00085 Thioredoxin","OC","KOG1672","ATP binding protein"]
["O14561","Acyl carrier protein"," mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3","NDUFAB1",1.416230257,0.012185217,"nochange",110634,134530,138650,182299,168484,192786,0.715781937,0.870384728,0.897040381,1.179441504,1.090060956,1.247290494,"mitochondria","K03955","NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1"," acyl-carrier protein","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0005975 carbohydrate metabolic process; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006464 cellular protein modification process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006664 glycolipid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009245 lipid A biosynthetic process; GO:0009247 glycolipid biosynthetic process; GO:0009249 protein lipoylation; GO:0009259 ribonucleotide metabolic process; GO:0009311 oligosaccharide metabolic process; GO:0009312 oligosaccharide biosynthetic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0010467 gene expression; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016051 carbohydrate biosynthetic process; GO:0016053 organic acid biosynthetic process; GO:0016310 phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032787 monocarboxylic acid metabolic process; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043436 oxoacid metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046467 membrane lipid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046493 lipid A metabolic process; GO:0051604 protein maturation; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901269 lipooligosaccharide metabolic process; GO:1901271 lipooligosaccharide biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1903509 liposaccharide metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045271 respiratory chain complex I; GO:0070013 intracellular organelle lumen; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0000035 acyl binding; GO:0000036 acyl carrier activity; GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0005488 binding; GO:0005504 fatty acid binding; GO:0005509 calcium ion binding; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0008289 lipid binding; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0019842 vitamin binding; GO:0031177 phosphopantetheine binding; GO:0031406 carboxylic acid binding; GO:0033218 amide binding; GO:0033293 monocarboxylic acid binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043177 organic acid binding; GO:0044620 ACP phosphopantetheine attachment site binding; GO:0046872 metal ion binding; GO:0050136 NADH dehydrogenase (quinone) activity; GO:0051192 prosthetic group binding; GO:0072341 modified amino acid binding; GO:0140104 molecular carrier activity;","PF00550","PF00550 Phosphopantetheine attachment site","CIQ","KOG1748","Acyl carrier protein/NADH-ubiquinone oxidoreductase"," NDUFAB1/SDAP subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-389661 Glyoxylate metabolism and glycine degradation;R-HSA-556833 Metabolism of lipids;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-389661;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-77289;https://reactome.org/PathwayBrowser/#/R-HSA-8978868","ADIPOGENESIS;MYC TARGETS V1;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O14576","Cytoplasmic dynein 1 intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1I1 PE=1 SV=2","DYNC1I1",0.770220113,0.086386243,"nochange",7560.93,7284.7,5484.87,4974.52,5727.92,4956.52,1.260524053,1.214472237,0.91441272,0.829329476,0.954932916,0.826328597,"nucleus","K10415","DYNC1I; dynein cytoplasmic 1 intermediate chain","hsa05132 Salmonella infection; hsa04145 Phagosome; hsa04962 Vasopressin-regulated water reabsorption","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0001654 eye development; GO:0001754 eye photoreceptor cell differentiation; GO:0002376 immune system process; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007291 sperm individualization; GO:0007349 cellularization; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0008088 axo-dendritic transport; GO:0008104 protein localization; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032781 positive regulation of ATP-dependent activity; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034501 protein localization to kinetochore; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0043085 positive regulation of catalytic activity; GO:0043462 regulation of ATP-dependent activity; GO:0044093 positive regulation of molecular function; GO:0044703 multi-organism reproductive process; GO:0046530 photoreceptor cell differentiation; GO:0046907 intracellular transport; GO:0047496 vesicle transport along microtubule; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048193 Golgi vesicle transport; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048592 eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050790 regulation of catalytic activity; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0060322 head development; GO:0061842 microtubule organizing center localization; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071459 protein localization to chromosome"," centromeric region; GO:0071840 cellular component organization or biogenesis; GO:0072384 organelle transport along microtubule; GO:0090596 sensory organ morphogenesis; GO:0099111 microtubule-based transport; GO:0099518 vesicle cytoskeletal trafficking;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005868 cytoplasmic dynein complex; GO:0005875 microtubule associated complex; GO:0005929 cilium; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0030286 dynein complex; GO:0030424 axon; GO:0031410 cytoplasmic vesicle; GO:0031514 motile cilium; GO:0031982 vesicle; GO:0032838 plasma membrane bounded cell projection cytoplasm; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036126 sperm flagellum; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0055037 recycling endosome; GO:0097708 intracellular vesicle; GO:0097729 9+2 motile cilium; GO:0098687 chromosomal region; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0120111 neuron projection cytoplasm; GO:1902494 catalytic complex; GO:1904115 axon cytoplasm; GO:1990904 ribonucleoprotein complex;","GO:0003774 cytoskeletal motor activity; GO:0003777 microtubule motor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017111 nucleoside-triphosphatase activity; GO:0030507 spectrin binding; GO:0034452 dynactin binding; GO:0045503 dynein light chain binding; GO:0045504 dynein heavy chain binding;",null,null,"Z","KOG1587","Cytoplasmic dynein intermediate chain","WP4532 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN;WP5085 VASOPRESSINREGULATED WATER REABSORPTION","http://www.wikipathways.org/instance/WP4532_r103287;http://www.wikipathways.org/instance/WP5085_r119785",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1632852 Macroautophagy;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-2132295 MHC class II antigen presentation;R-HSA-2262752 Cellular responses to stress;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-8953897 Cellular responses to stimuli;R-HSA-948021 Transport to the Golgi and subsequent modification;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9612973 Autophagy;R-HSA-9646399 Aggrephagy;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9663891 Selective autophagy;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3"]
["O14578","Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2","CIT",0.470718072,0.001149128,"down",10433.5,10268.3,9793.63,3968.53,5181.81,5204.41,1.395780351,1.373680106,1.310179357,0.530904893,0.693215947,0.696239346,"nucleus","K16308",null,null,"GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000281 mitotic cytokinesis; GO:0000819 sister chromatid segregation; GO:0000910 cytokinesis; GO:0000912 assembly of actomyosin apparatus involved in cytokinesis; GO:0000915 actomyosin contractile ring assembly; GO:0006325 chromatin organization; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007030 Golgi organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007088 regulation of mitotic nuclear division; GO:0007091 metaphase/anaphase transition of mitotic cell cycle; GO:0007112 male meiosis cytokinesis; GO:0007140 male meiotic nuclear division; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010564 regulation of cell cycle process; GO:0010721 negative regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010965 regulation of mitotic sister chromatid separation; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016358 dendrite development; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030832 regulation of actin filament length; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031032 actomyosin structure organization; GO:0031175 neuron projection development; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032465 regulation of cytokinesis; GO:0032467 positive regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032506 cytokinetic process; GO:0032535 regulation of cellular component size; GO:0032954 regulation of cytokinetic process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033206 meiotic cytokinesis; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044784 metaphase/anaphase transition of cell cycle; GO:0044837 actomyosin contractile ring organization; GO:0044839 cell cycle G2/M phase transition; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045787 positive regulation of cell cycle; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050774 negative regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051302 regulation of cell division; GO:0051321 meiotic cell cycle; GO:0051402 neuron apoptotic process; GO:0051493 regulation of cytoskeleton organization; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0051783 regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051983 regulation of chromosome segregation; GO:0060284 regulation of cell development; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070997 neuron death; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090068 positive regulation of cell cycle process; GO:0098813 nuclear chromosome segregation; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1902903 regulation of supramolecular fiber organization; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1905818 regulation of chromosome separation; GO:2000026 regulation of multicellular organismal development; GO:2000171 negative regulation of dendrite development; GO:2000431 regulation of cytokinesis"," actomyosin contractile ring assembly;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005773 vacuole; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005826 actomyosin contractile ring; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030496 midbody; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0031252 cell leading edge; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0032153 cell division site; GO:0032154 cleavage furrow; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0070938 contractile ring; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030165 PDZ domain binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0097110 scaffold protein binding; GO:0140096 catalytic activity"," acting on a protein;","PF00069; PF00169","PF00069 Protein kinase domain; PF00169 PH domain","T","KOG0976","Rho/Rac1-interacting serine/threonine kinase Citron","WP524 G13 SIGNALING PATHWAY;WP5087 MALIGNANT PLEURAL MESOTHELIOMA","http://www.wikipathways.org/instance/WP524_r117113;http://www.wikipathways.org/instance/WP5087_r120373",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-5625900 RHO GTPases activate CIT;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-5625900;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["O14579","Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3","COPE",0.78188944,0.028629864,"nochange",32963.7,33308.1,31988,28316.6,22084.8,26426.9,1.129615319,1.141417378,1.09617958,0.970366347,0.756812142,0.905609233,"cytoplasm","K17268",null,null,"GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006891 intra-Golgi vesicle-mediated transport; GO:0016192 vesicle-mediated transport; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030120 vesicle coat; GO:0030126 COPI vesicle coat; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030137 COPI-coated vesicle; GO:0030659 cytoplasmic vesicle membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030663 COPI-coated vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048475 coated membrane; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;",{"$nulls":3},"U","KOG3081","Vesicle coat complex COPI"," epsilon subunit",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-948021","PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O14617","AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1","AP3D1",1.063926829,0.236938995,"nochange",15706.8,16458.1,17100.8,16219.6,18035.5,18160,0.926829844,0.971162697,1.009087261,0.957089244,1.064242217,1.071588737,"cytoplasm","K12396","AP3D; AP-3 complex subunit delta","hsa04142 Lysosome","GO:0000041 transition metal ion transport; GO:0002376 immune system process; GO:0002475 antigen processing and presentation via MHC class Ib; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006725 cellular aromatic compound metabolic process; GO:0006726 eye pigment biosynthetic process; GO:0006727 ommochrome biosynthetic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006829 zinc ion transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006895 Golgi to endosome transport; GO:0006897 endocytosis; GO:0006900 vesicle budding from membrane; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007033 vacuole organization; GO:0007034 vacuolar transport; GO:0007040 lysosome organization; GO:0007041 lysosomal transport; GO:0007220 Notch receptor processing; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008055 ocellus pigment biosynthetic process; GO:0008057 eye pigment granule organization; GO:0008088 axo-dendritic transport; GO:0008089 anterograde axonal transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008333 endosome to lysosome transport; GO:0008340 determination of adult lifespan; GO:0009058 biosynthetic process; GO:0009605 response to external stimulus; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010970 transport along microtubule; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016182 synaptic vesicle budding from endosome; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019748 secondary metabolic process; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0021700 developmental maturation; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0030001 metal ion transport; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031503 protein-containing complex localization; GO:0032438 melanosome organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032594 protein transport within lipid bilayer; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033059 cellular pigmentation; GO:0033060 ocellus pigmentation; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0035646 endosome to melanosome transport; GO:0036465 synaptic vesicle recycling; GO:0036466 synaptic vesicle recycling via endosome; GO:0042440 pigment metabolic process; GO:0042441 eye pigment metabolic process; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043324 pigment metabolic process involved in developmental pigmentation; GO:0043473 pigmentation; GO:0043474 pigment metabolic process involved in pigmentation; GO:0043476 pigment accumulation; GO:0043482 cellular pigment accumulation; GO:0043485 endosome to pigment granule transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044550 secondary metabolite biosynthetic process; GO:0045184 establishment of protein localization; GO:0045580 regulation of T cell differentiation; GO:0045582 positive regulation of T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045621 positive regulation of lymphocyte differentiation; GO:0045785 positive regulation of cell adhesion; GO:0046148 pigment biosynthetic process; GO:0046152 ommochrome metabolic process; GO:0046158 ocellus pigment metabolic process; GO:0046483 heterocycle metabolic process; GO:0046634 regulation of alpha-beta T cell activation; GO:0046635 positive regulation of alpha-beta T cell activation; GO:0046637 regulation of alpha-beta T cell differentiation; GO:0046638 positive regulation of alpha-beta T cell differentiation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0047496 vesicle transport along microtubule; GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib; GO:0048007 antigen processing and presentation"," exogenous lipid antigen via MHC class Ib; GO:0048066 developmental pigmentation; GO:0048069 eye pigmentation; GO:0048072 compound eye pigmentation; GO:0048193 Golgi vesicle transport; GO:0048489 synaptic vesicle transport; GO:0048490 anterograde synaptic vesicle transport; GO:0048499 synaptic vesicle membrane organization; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048753 pigment granule organization; GO:0048757 pigment granule maturation; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0050931 pigment cell differentiation; GO:0051094 positive regulation of developmental process; GO:0051136 regulation of NK T cell differentiation; GO:0051138 positive regulation of NK T cell differentiation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051668 localization within membrane; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060966 regulation of gene silencing by RNA; GO:0060967 negative regulation of gene silencing by RNA; GO:0061024 membrane organization; GO:0061088 regulation of sequestering of zinc ion; GO:0061462 protein localization to lysosome; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070142 synaptic vesicle budding; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072384 organelle transport along microtubule; GO:0072594 establishment of protein localization to organelle; GO:0072657 protein localization to membrane; GO:0072665 protein localization to vacuole; GO:0072666 establishment of protein localization to vacuole; GO:0080171 lytic vacuole organization; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098657 import into cell; GO:0098930 axonal transport; GO:0098943 neurotransmitter receptor transport"," postsynaptic endosome to lysosome; GO:0099003 vesicle-mediated transport in synapse; GO:0099111 microtubule-based transport; GO:0099504 synaptic vesicle cycle; GO:0099514 synaptic vesicle cytoskeletal transport; GO:0099517 synaptic vesicle transport along microtubule; GO:0099518 vesicle cytoskeletal trafficking; GO:0099532 synaptic vesicle endosomal processing; GO:0099632 protein transport within plasma membrane; GO:0099637 neurotransmitter receptor transport; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005770 late endosome; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005798 Golgi-associated vesicle; GO:0005802 trans-Golgi network; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0030123 AP-3 adaptor complex; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048475 coated membrane; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098796 membrane protein complex; GO:0098830 presynaptic endosome; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005215 transporter activity;",null,null,"U","KOG1059","Vesicle coat complex AP-3"," delta subunit"]
["O14618","Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1","CCS",0.702114204,0.000440096,"down",26598.3,26142.2,26003.1,18032.8,17630.7,19623.5,1.190696751,1.170279026,1.16405209,0.807254463,0.789254096,0.878463575,"extracellular","K04569","CCS; copper chaperone for superoxide dismutase","hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis","GO:0000041 transition metal ion transport; GO:0006801 superoxide metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006825 copper ion transport; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0015680 protein maturation by copper ion transfer; GO:0019222 regulation of metabolic process; GO:0030001 metal ion transport; GO:0031647 regulation of protein stability; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034599 cellular response to oxidative stress; GO:0042221 response to chemical; GO:0043085 positive regulation of catalytic activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050821 protein stabilization; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051341 regulation of oxidoreductase activity; GO:0051353 positive regulation of oxidoreductase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0072593 reactive oxygen species metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005758 mitochondrial intermembrane space; GO:0005777 peroxisome; GO:0005829 cytosol; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005507 copper ion binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008270 zinc ion binding; GO:0015035 protein-disulfide reductase activity; GO:0015036 disulfide oxidoreductase activity; GO:0016491 oxidoreductase activity; GO:0016530 metallochaperone activity; GO:0016531 copper chaperone activity; GO:0016532 superoxide dismutase copper chaperone activity; GO:0016667 oxidoreductase activity"," acting on a sulfur group of donors; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0098772 molecular function regulator; GO:0140104 molecular carrier activity;","PF00403; PF00080","PF00403 Heavy-metal-associated domain; PF00080 Copper/zinc superoxide dismutase (SODC)","P","KOG4656","Copper chaperone for superoxide dismutase","WP2447 AMYOTROPHIC LATERAL SCLEROSIS ALS;WP3286 COPPER HOMEOSTASIS","http://www.wikipathways.org/instance/WP2447_r113794;http://www.wikipathways.org/instance/WP3286_r106367",null,"R-HSA-2262752 Cellular responses to stress;R-HSA-3299685 Detoxification of Reactive Oxygen Species;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3299685;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9711123"]
["O14641","Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1","DVL2",0.635280547,0.000534489,"down",6096.93,5619.26,5319.26,3460.42,3681.3,3680.57,1.313156774,1.21027621,1.145662211,0.745305254,0.792878389,0.792721161,"nucleus","K02353","DVL; segment polarity protein dishevelled","hsa05224 Breast cancer; hsa05217 Basal cell carcinoma; hsa04150 mTOR signaling pathway; hsa05200 Pathways in cancer; hsa05010 Alzheimer disease; hsa04310 Wnt signaling pathway; hsa04916 Melanogenesis; hsa04550 Signaling pathways regulating pluripotency of stem cells; hsa05165 Human papillomavirus infection; hsa05225 Hepatocellular carcinoma; hsa04390 Hippo signaling pathway; hsa05226 Gastric cancer; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa04934 Cushing syndrome; hsa04330 Notch signaling pathway","GO:0000003 reproduction; GO:0000132 establishment of mitotic spindle orientation; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001558 regulation of cell growth; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001702 gastrulation with mouth forming second; GO:0001704 formation of primary germ layer; GO:0001706 endoderm formation; GO:0001708 cell fate specification; GO:0001711 endodermal cell fate commitment; GO:0001714 endodermal cell fate specification; GO:0001736 establishment of planar polarity; GO:0001737 establishment of imaginal disc-derived wing hair orientation; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001838 embryonic epithelial tube formation; GO:0001839 neural plate morphogenesis; GO:0001840 neural plate development; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002011 morphogenesis of an epithelial sheet; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003007 heart morphogenesis; GO:0003151 outflow tract morphogenesis; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007346 regulation of mitotic cell cycle; GO:0007350 blastoderm segmentation; GO:0007365 periodic partitioning; GO:0007367 segment polarity determination; GO:0007369 gastrulation; GO:0007379 segment specification; GO:0007389 pattern specification process; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007492 endoderm development; GO:0007507 heart development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008039 synaptic target recognition; GO:0008045 motor neuron axon guidance; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008356 asymmetric cell division; GO:0008361 regulation of cell size; GO:0008406 gonad development; GO:0008544 epidermis development; GO:0008585 female gonad development; GO:0008587 imaginal disc-derived wing margin morphogenesis; GO:0008593 regulation of Notch signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009913 epidermal cell differentiation; GO:0009948 anterior/posterior axis specification; GO:0009950 dorsal/ventral axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014020 primary neural tube formation; GO:0014022 neural plate elongation; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016055 Wnt signaling pathway; GO:0016070 RNA metabolic process; GO:0016201 synaptic target inhibition; GO:0016331 morphogenesis of embryonic epithelium; GO:0016348 imaginal disc-derived leg joint morphogenesis; GO:0016477 cell migration; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0021915 neural tube development; GO:0022007 convergent extension involved in neural plate elongation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022612 gland morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030010 establishment of cell polarity; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030516 regulation of axon extension; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0030859 polarized epithelial cell differentiation; GO:0031023 microtubule organizing center organization; GO:0031175 neuron projection development; GO:0031290 retinal ganglion cell axon guidance; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032053 ciliary basal body organization; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032231 regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032774 RNA biosynthetic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032984 protein-containing complex disassembly; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033674 positive regulation of kinase activity; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035019 somatic stem cell population maintenance; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035089 establishment of apical/basal cell polarity; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035148 tube formation; GO:0035150 regulation of tube size; GO:0035151 regulation of tube size"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035159 regulation of tube length"," open tracheal system; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035262 gonad morphogenesis; GO:0035272 exocrine system development; GO:0035282 segmentation; GO:0035285 appendage segmentation; GO:0035295 tube development; GO:0035309 wing and notum subfield formation; GO:0035315 hair cell differentiation; GO:0035316 non-sensory hair organization; GO:0035317 imaginal disc-derived wing hair organization; GO:0035329 hippo signaling; GO:0035556 intracellular signal transduction; GO:0035567 non-canonical Wnt signaling pathway; GO:0035987 endodermal cell differentiation; GO:0036011 imaginal disc-derived leg segmentation; GO:0040001 establishment of mitotic spindle localization; GO:0040007 growth; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042067 establishment of ommatidial planar polarity; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042471 ear morphogenesis; GO:0042472 inner ear morphogenesis; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0043583 ear development; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation; GO:0044703 multi-organism reproductive process; GO:0044782 cilium organization; GO:0045137 development of primary sexual characteristics; GO:0045165 cell fate commitment; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045198 establishment of epithelial cell apical/basal polarity; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045746 negative regulation of Notch signaling pathway; GO:0045773 positive regulation of axon extension; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045995 regulation of embryonic development; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046483 heterocycle metabolic process; GO:0046545 development of primary female sexual characteristics; GO:0046660 female sex differentiation; GO:0048013 ephrin receptor signaling pathway; GO:0048070 regulation of developmental pigmentation; GO:0048073 regulation of eye pigmentation; GO:0048076 regulation of compound eye pigmentation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048546 digestive tract morphogenesis; GO:0048557 embryonic digestive tract morphogenesis; GO:0048562 embryonic organ morphogenesis; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048565 digestive tract development; GO:0048566 embryonic digestive tract development; GO:0048568 embryonic organ development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048645 animal organ formation; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048730 epidermis morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0050896 response to stimulus; GO:0050919 negative chemotaxis; GO:0050920 regulation of chemotaxis; GO:0050921 positive regulation of chemotaxis; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051301 cell division; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0055123 digestive system development; GO:0060026 convergent extension; GO:0060027 convergent extension involved in gastrulation; GO:0060029 convergent extension involved in organogenesis; GO:0060069 Wnt signaling pathway"," regulating spindle positioning; GO:0060070 canonical Wnt signaling pathway; GO:0060071 Wnt signaling pathway"," planar cell polarity pathway; GO:0060255 regulation of macromolecule metabolic process; GO:0060271 cilium assembly; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0060795 cell fate commitment involved in formation of primary germ layer; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0060914 heart formation; GO:0060972 left/right pattern formation; GO:0061024 membrane organization; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061098 positive regulation of protein tyrosine kinase activity; GO:0061162 establishment of monopolar cell polarity; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061339 establishment or maintenance of monopolar cell polarity; GO:0061387 regulation of extent of cell growth; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0070986 left/right axis specification; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090102 cochlea development; GO:0090103 cochlea morphogenesis; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090162 establishment of epithelial cell polarity; GO:0090163 establishment of epithelial cell planar polarity; GO:0090175 regulation of establishment of planar polarity; GO:0090178 regulation of establishment of planar polarity involved in neural tube closure; GO:0090179 planar cell polarity pathway involved in neural tube closure; GO:0090263 positive regulation of canonical Wnt signaling pathway; GO:0090304 nucleic acid metabolic process; GO:0090596 sensory organ morphogenesis; GO:0090630 activation of GTPase activity; GO:0097485 neuron projection guidance; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0150011 regulation of neuron projection arborization; GO:0150012 positive regulation of neuron projection arborization; GO:0198738 cell-cell signaling by wnt; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902667 regulation of axon guidance; GO:1902669 positive regulation of axon guidance; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902903 regulation of supramolecular fiber organization; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904886 beta-catenin destruction complex disassembly; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:1905276 regulation of epithelial tube formation; GO:1905330 regulation of morphogenesis of an epithelium; GO:1990138 neuron projection extension; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0005938 cell cortex; GO:0009986 cell surface; GO:0016020 membrane; GO:0016234 inclusion body; GO:0016235 aggresome; GO:0016328 lateral plasma membrane; GO:0016604 nuclear body; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0035253 ciliary rootlet; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045177 apical part of cell; GO:0045179 apical cortex; GO:0045334 clathrin-coated endocytic vesicle; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection;","GO:0001664 G protein-coupled receptor binding; GO:0005102 signaling receptor binding; GO:0005109 frizzled binding; GO:0005112 Notch binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030159 signaling receptor complex adaptor activity; GO:0030674 protein-macromolecule adaptor activity; GO:0030971 receptor tyrosine kinase binding; GO:0031267 small GTPase binding; GO:0035591 signaling adaptor activity; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043394 proteoglycan binding; GO:0043621 protein self-association; GO:0045545 syndecan binding; GO:0046875 ephrin receptor binding; GO:0051020 GTPase binding; GO:0060090 molecular adaptor activity; GO:0070300 phosphatidic acid binding; GO:0097367 carbohydrate derivative binding; GO:1990782 protein tyrosine kinase binding;","PF00595; PF00610","PF00595 PDZ domain; PF00610 Domain found in Dishevelled"," Egl-10"," and Pleckstrin (DEP)","R","KOG3571","Dishevelled 3 and related proteins","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP4262 BREAST CANCER PATHWAY;WP710 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT;WP3931 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS;WP4258 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP4336 NCRNAS INVOLVED IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA;WP2064 NEURAL CREST DIFFERENTIATION;WP268 NOTCH SIGNALING;WP3664 REGULATION OF WNT BCATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS;WP4241 TYPE 2 PAPILLARY RENAL CELL CARCINOMA;WP428 WNT SIGNALING;WP4150 WNT SIGNALING IN KIDNEY DISEASE;WP363 WNT SIGNALING PATHWAY;WP399 WNT SIGNALING PATHWAY AND PLURIPOTENCY","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP4262_r108103;http://www.wikipathways.org/instance/WP710_r116542;http://www.wikipathways.org/instance/WP3931_r117717;http://www.wikipathways.org/instance/WP4258_r117770;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP4336_r108198;http://www.wikipathways.org/instance/WP2064_r117162;http://www.wikipathways.org/instance/WP268_r117167;http://www.wikipathways.org/instance/WP3664_r118061;http://www.wikipathways.org/instance/WP4241_r106520;http://www.wikipathways.org/instance/WP428_r116549;http://www.wikipathways.org/instance/WP4150_r116677;http://www.wikipathways.org/instance/WP363_r120695;http://www.wikipathways.org/instance/WP399_r119242",null,"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-195721 Signaling by WNT;R-HSA-199991 Membrane Trafficking;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-201688 WNT mediated activation of DVL;R-HSA-2028269 Signaling by Hippo;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-4086400 PCP/CE pathway;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641258 Degradation of DVL;R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane;R-HSA-5099900 WNT5A-dependent internalization of FZD4;R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9658195 Leishmania infection;R-HSA-9664420 Killing mechanisms;R-HSA-9673324 WNT5:FZD7-mediated leishmania damping;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-201681;https://reactome.org/PathwayBrowser/#/R-HSA-201688;https://reactome.org/PathwayBrowser/#/R-HSA-2028269;https://reactome.org/PathwayBrowser/#/R-HSA-3858494;https://reactome.org/PathwayBrowser/#/R-HSA-4086400;https://reactome.org/PathwayBrowser/#/R-HSA-4608870;https://reactome.org/PathwayBrowser/#/R-HSA-4641258;https://reactome.org/PathwayBrowser/#/R-HSA-4641262;https://reactome.org/PathwayBrowser/#/R-HSA-5099900;https://reactome.org/PathwayBrowser/#/R-HSA-5368598;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664420;https://reactome.org/PathwayBrowser/#/R-HSA-9673324;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","WNT BETA CATENIN SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_WNT_BETA_CATENIN_SIGNALING"]
["O14646","Chromodomain-helicase-DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=CHD1 PE=1 SV=2","CHD1",1.126738098,0.079166833,"nochange",13823.6,15233.5,15582.2,17390.5,17303.7,15602.6,0.873657123,0.962763375,0.984801356,1.099086649,1.093600854,0.986090644,"nucleus","K11367",null,null,"GO:0000003 reproduction; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007088 regulation of mitotic nuclear division; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007338 single fertilization; GO:0007346 regulation of mitotic cell cycle; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007517 muscle organ development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008152 metabolic process; GO:0009566 fertilization; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0016310 phosphorylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030154 cell differentiation; GO:0030490 maturation of SSU-rRNA; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032239 regulation of nucleobase-containing compound transport; GO:0032241 positive regulation of nucleobase-containing compound transport; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032392 DNA geometric change; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032508 DNA duplex unwinding; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033157 regulation of intracellular protein transport; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0034728 nucleosome organization; GO:0035039 male pronucleus assembly; GO:0035041 sperm DNA decondensation; GO:0035042 fertilization"," exchange of chromosomal proteins; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035821 modulation of process of another organism; GO:0036211 protein modification process; GO:0042254 ribosome biogenesis; GO:0042274 ribosomal small subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043486 histone exchange; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043921 modulation by host of viral transcription; GO:0043923 positive regulation by host of viral transcription; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046777 protein autophosphorylation; GO:0046782 regulation of viral transcription; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046825 regulation of protein export from nucleus; GO:0046827 positive regulation of protein export from nucleus; GO:0046831 regulation of RNA export from nucleus; GO:0046833 positive regulation of RNA export from nucleus; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050434 positive regulation of viral transcription; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051702 biological process involved in interaction with symbiont; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051851 modulation by host of symbiont process; GO:0051983 regulation of chromosome segregation; GO:0052472 modulation by host of symbiont transcription; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070925 organelle assembly; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090069 regulation of ribosome biogenesis; GO:0090070 positive regulation of ribosome biogenesis; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0090316 positive regulation of intracellular protein transport; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903829 positive regulation of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905818 regulation of chromosome separation; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000197 regulation of ribonucleoprotein complex localization; GO:2000199 positive regulation of ribonucleoprotein complex localization; GO:2000200 regulation of ribosomal subunit export from nucleus; GO:2000202 positive regulation of ribosomal subunit export from nucleus; GO:2000206 regulation of ribosomal small subunit export from nucleus; GO:2000208 positive regulation of ribosomal small subunit export from nucleus; GO:2000232 regulation of rRNA processing; GO:2000234 positive regulation of rRNA processing; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005705 polytene chromosome interband; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0030684 preribosome; GO:0030688 preribosome"," small subunit precursor; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1990904 ribonucleoprotein complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00385; PF00176; PF00271; PF18375; PF13907","PF00385 Chromo (CHRromatin Organisation MOdifier) domain; PF00176 SNF2-related domain; PF00271 Helicase conserved C-terminal domain; PF18375 CDH1/2 SANT-Helical linker 1; PF13907 Domain of unknown function (DUF4208)","K","KOG0384","Chromodomain-helicase DNA-binding protein","WP5144 NRP1TRIGGERED SIGNALING PATHWAYS IN PANCREATIC CANCER","http://www.wikipathways.org/instance/WP5144_r120537","Transcription factor","R-HSA-162582 Signal Transduction;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9018519 Estrogen-dependent gene expression","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9018519"]
["O14647","Chromodomain-helicase-DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=CHD2 PE=1 SV=2","CHD2",0.922331976,0.20816477,"nochange",10173.3,11576,10960.3,9921.38,9450.33,10797.4,0.970754648,1.104602814,1.045851609,0.946715987,0.901767546,1.030307397,"nucleus","K20091",null,null,"GO:0000003 reproduction; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002244 hematopoietic progenitor cell differentiation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003006 developmental process involved in reproduction; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007338 single fertilization; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007517 muscle organ development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008152 metabolic process; GO:0009566 fertilization; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032392 DNA geometric change; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032508 DNA duplex unwinding; GO:0033554 cellular response to stress; GO:0034728 nucleosome organization; GO:0035039 male pronucleus assembly; GO:0035041 sperm DNA decondensation; GO:0035042 fertilization"," exchange of chromosomal proteins; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035821 modulation of process of another organism; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043486 histone exchange; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043921 modulation by host of viral transcription; GO:0043923 positive regulation by host of viral transcription; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0046782 regulation of viral transcription; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048524 positive regulation of viral process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0048863 stem cell differentiation; GO:0048869 cellular developmental process; GO:0050434 positive regulation of viral transcription; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051702 biological process involved in interaction with symbiont; GO:0051716 cellular response to stimulus; GO:0051851 modulation by host of symbiont process; GO:0052472 modulation by host of symbiont transcription; GO:0060218 hematopoietic stem cell differentiation; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070925 organelle assembly; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005705 polytene chromosome interband; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00385; PF00176; PF00271; PF18375; PF13907","PF00385 Chromo (CHRromatin Organisation MOdifier) domain; PF00176 SNF2-related domain; PF00271 Helicase conserved C-terminal domain; PF18375 CDH1/2 SANT-Helical linker 1; PF13907 Domain of unknown function (DUF4208)","K","KOG0384","Chromodomain-helicase DNA-binding protein","WP4673 MALE INFERTILITY;WP5144 NRP1TRIGGERED SIGNALING PATHWAYS IN PANCREATIC CANCER;WP3995 PRION DISEASE PATHWAY","http://www.wikipathways.org/instance/WP4673_r119920;http://www.wikipathways.org/instance/WP5144_r120537;http://www.wikipathways.org/instance/WP3995_r119304","Transcription factor"]
["O14653","Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2","GOSR2",0.946009829,0.565812507,"nochange",2673.07,2290.58,2884.26,2664.55,2529.46,2230.19,1.050177088,0.899907086,1.133147941,1.0468298090000001,0.993756593,0.876181484,"cytoplasm","K08496","GOSR2; golgi SNAP receptor complex member 2","hsa04130 SNARE interactions in vesicular transport","GO:0006605 protein targeting; GO:0006623 protein targeting to vacuole; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006891 intra-Golgi vesicle-mediated transport; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006896 Golgi to vacuole transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006906 vesicle fusion; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0007034 vacuolar transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034620 cellular response to unfolded protein; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036498 IRE1-mediated unfolded protein response; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048280 vesicle fusion with Golgi apparatus; GO:0048284 organelle fusion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072665 protein localization to vacuole; GO:0072666 establishment of protein localization to vacuole; GO:0090114 COPII-coated vesicle budding; GO:0090174 organelle membrane fusion;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005770 late endosome; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0012507 ER to Golgi transport vesicle membrane; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030134 COPII-coated ER to Golgi transport vesicle; GO:0030135 coated vesicle; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0030662 coated vesicle membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000149 SNARE binding; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding;","PF12352","PF12352 Snare region anchored in the vesicle membrane C-terminus","U","KOG3251","Golgi SNAP receptor complex member",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-2262752 Cellular responses to stress;R-HSA-381038 XBP1(S) activates chaperone genes;R-HSA-381070 IRE1alpha activates chaperones;R-HSA-381119 Unfolded Protein Response (UPR);R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5694530 Cargo concentration in the ER;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811438 Intra-Golgi traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8953897 Cellular responses to stimuli;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-381038;https://reactome.org/PathwayBrowser/#/R-HSA-381070;https://reactome.org/PathwayBrowser/#/R-HSA-381119;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5694530;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811438;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-948021","PROTEIN SECRETION;UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["O14656","Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1","TOR1A",0.989540077,0.80648121,"nochange",11775,11295.9,10715.2,10499.4,11623.4,11309.9,1.051045243,1.008280422,0.956446708,0.93718424,1.037513315,1.009530072,"endoplasmic reticulum","K22990",null,null,"GO:0000338 protein deneddylation; GO:0001505 regulation of neurotransmitter levels; GO:0001558 regulation of cell growth; GO:0002009 morphogenesis of an epithelium; GO:0002011 morphogenesis of an epithelial sheet; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002168 instar larval development; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006457 protein folding; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006515 protein quality control for misfolded or incompletely synthesized proteins; GO:0006611 protein export from nucleus; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006998 nuclear envelope organization; GO:0007010 cytoskeleton organization; GO:0007029 endoplasmic reticulum organization; GO:0007155 cell adhesion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007503 fat body development; GO:0007504 larval fat body development; GO:0007591 molting cycle"," chitin-based cuticle; GO:0007593 chitin-based cuticle sclerotization; GO:0008057 eye pigment granule organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010256 endomembrane system organization; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010866 regulation of triglyceride biosynthetic process; GO:0010868 negative regulation of triglyceride biosynthetic process; GO:0010883 regulation of lipid storage; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022404 molting cycle process; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0030030 cell projection organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0032225 regulation of synaptic transmission"," dopaminergic; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033059 cellular pigmentation; GO:0033238 regulation of cellular amine metabolic process; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034976 response to endoplasmic reticulum stress; GO:0035303 regulation of dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042053 regulation of dopamine metabolic process; GO:0042060 wound healing; GO:0042069 regulation of catecholamine metabolic process; GO:0042221 response to chemical; GO:0042303 molting cycle; GO:0042335 cuticle development; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043095 regulation of GTP cyclohydrolase I activity; GO:0043104 positive regulation of GTP cyclohydrolase I activity; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043412 macromolecule modification; GO:0043473 pigmentation; GO:0043523 regulation of neuron apoptotic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044319 wound healing"," spreading of cells; GO:0045103 intermediate filament-based process; GO:0045104 intermediate filament cytoskeleton organization; GO:0045184 establishment of protein localization; GO:0045807 positive regulation of endocytosis; GO:0045833 negative regulation of lipid metabolic process; GO:0045927 positive regulation of growth; GO:0045936 negative regulation of phosphate metabolic process; GO:0046467 membrane lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0046907 intracellular transport; GO:0048066 developmental pigmentation; GO:0048067 cuticle pigmentation; GO:0048085 adult chitin-containing cuticle pigmentation; GO:0048468 cell development; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048753 pigment granule organization; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048878 chemical homeostasis; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051055 negative regulation of lipid biosynthetic process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051580 regulation of neurotransmitter uptake; GO:0051584 regulation of dopamine uptake involved in synaptic transmission; GO:0051588 regulation of neurotransmitter transport; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051788 response to misfolded protein; GO:0051940 regulation of catecholamine uptake involved in synaptic transmission; GO:0051952 regulation of amine transport; GO:0055088 lipid homeostasis; GO:0055090 acylglycerol homeostasis; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060612 adipose tissue development; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061077 chaperone-mediated protein folding; GO:0061448 connective tissue development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070050 neuron cellular homeostasis; GO:0070328 triglyceride homeostasis; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071071 regulation of phospholipid biosynthetic process; GO:0071072 negative regulation of phospholipid biosynthetic process; GO:0071166 ribonucleoprotein complex localization; GO:0071218 cellular response to misfolded protein; GO:0071310 cellular response to organic substance; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071712 ER-associated misfolded protein catabolic process; GO:0071763 nuclear membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090207 regulation of triglyceride metabolic process; GO:0090209 negative regulation of triglyceride metabolic process; GO:0090504 epiboly; GO:0090505 epiboly involved in wound healing; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098693 regulation of synaptic vesicle cycle; GO:0099003 vesicle-mediated transport in synapse; GO:0099177 regulation of trans-synaptic signaling; GO:0120036 plasma membrane bounded cell projection organization; GO:1900242 regulation of synaptic vesicle endocytosis; GO:1900244 positive regulation of synaptic vesicle endocytosis; GO:1901214 regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901698 response to nitrogen compound; GO:1903421 regulation of synaptic vesicle recycling; GO:1903423 positive regulation of synaptic vesicle recycling; GO:1903725 regulation of phospholipid metabolic process; GO:1903726 negative regulation of phospholipid metabolic process; GO:1903730 regulation of phosphatidate phosphatase activity; GO:1903741 negative regulation of phosphatidate phosphatase activity; GO:1905952 regulation of lipid localization; GO:2000008 regulation of protein localization to cell surface; GO:2001023 regulation of response to drug;","GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005789 endoplasmic reticulum membrane; GO:0005818 aster; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030133 transport vesicle; GO:0030141 secretory granule; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0030659 cytoplasmic vesicle membrane; GO:0031090 organelle membrane; GO:0031312 extrinsic component of organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042406 extrinsic component of endoplasmic reticulum membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0098827 endoplasmic reticulum subcompartment; GO:0099080 supramolecular complex; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008092 cytoskeletal protein binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019894 kinesin binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0051082 unfolded protein binding; GO:0051787 misfolded protein binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG2170","ATPase of the AAA+ superfamily",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828"]
["O14657","Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2","TOR1B",0.632986507,0.070562752,"nochange",6773.95,4098.79,5426.47,3222.53,2885.98,4208.67,1.527017751,0.92396978,1.223262058,0.72643886,0.650572072,0.94873948,"extracellular","K22990",null,null,"GO:0001558 regulation of cell growth; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002168 instar larval development; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006998 nuclear envelope organization; GO:0007029 endoplasmic reticulum organization; GO:0007275 multicellular organism development; GO:0007503 fat body development; GO:0007504 larval fat body development; GO:0007591 molting cycle"," chitin-based cuticle; GO:0007593 chitin-based cuticle sclerotization; GO:0008057 eye pigment granule organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009791 post-embryonic development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0010468 regulation of gene expression; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010866 regulation of triglyceride biosynthetic process; GO:0010868 negative regulation of triglyceride biosynthetic process; GO:0010883 regulation of lipid storage; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0021700 developmental maturation; GO:0022404 molting cycle process; GO:0022607 cellular component assembly; GO:0030307 positive regulation of cell growth; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033059 cellular pigmentation; GO:0033238 regulation of cellular amine metabolic process; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0035303 regulation of dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042053 regulation of dopamine metabolic process; GO:0042069 regulation of catecholamine metabolic process; GO:0042221 response to chemical; GO:0042303 molting cycle; GO:0042335 cuticle development; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043095 regulation of GTP cyclohydrolase I activity; GO:0043104 positive regulation of GTP cyclohydrolase I activity; GO:0043473 pigmentation; GO:0043523 regulation of neuron apoptotic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045184 establishment of protein localization; GO:0045833 negative regulation of lipid metabolic process; GO:0045927 positive regulation of growth; GO:0045936 negative regulation of phosphate metabolic process; GO:0046467 membrane lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0046907 intracellular transport; GO:0048066 developmental pigmentation; GO:0048067 cuticle pigmentation; GO:0048085 adult chitin-containing cuticle pigmentation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048569 post-embryonic animal organ development; GO:0048731 system development; GO:0048753 pigment granule organization; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051055 negative regulation of lipid biosynthetic process; GO:0051128 regulation of cellular component organization; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051788 response to misfolded protein; GO:0055088 lipid homeostasis; GO:0055090 acylglycerol homeostasis; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060612 adipose tissue development; GO:0061024 membrane organization; GO:0061448 connective tissue development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070050 neuron cellular homeostasis; GO:0070328 triglyceride homeostasis; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071071 regulation of phospholipid biosynthetic process; GO:0071072 negative regulation of phospholipid biosynthetic process; GO:0071166 ribonucleoprotein complex localization; GO:0071218 cellular response to misfolded protein; GO:0071310 cellular response to organic substance; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071763 nuclear membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090207 regulation of triglyceride metabolic process; GO:0090209 negative regulation of triglyceride metabolic process; GO:1901214 regulation of neuron death; GO:1901576 organic substance biosynthetic process; GO:1903725 regulation of phospholipid metabolic process; GO:1903726 negative regulation of phospholipid metabolic process; GO:1903730 regulation of phosphatidate phosphatase activity; GO:1903741 negative regulation of phosphatidate phosphatase activity; GO:1905952 regulation of lipid localization;","GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005818 aster; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0099080 supramolecular complex;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG2170","ATPase of the AAA+ superfamily",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828","INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["O14662","Syntaxin-16 OS=Homo sapiens OX=9606 GN=STX16 PE=1 SV=3","STX16",0.818644854,0.092590011,"nochange",3893.75,3034.08,3634.87,2955.1,2609.95,3082.05,1.216176118,0.947666295,1.13531739,0.922997637,0.815193287,0.962649273,"mitochondria","K08489","STX16; syntaxin 16","hsa04130 SNARE interactions in vesicular transport","GO:0001505 regulation of neurotransmitter levels; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006904 vesicle docking involved in exocytosis; GO:0006906 vesicle fusion; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016081 synaptic vesicle docking; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0017156 calcium-ion regulated exocytosis; GO:0022406 membrane docking; GO:0023052 signaling; GO:0023061 signal release; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042886 amide transport; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048278 vesicle docking; GO:0048284 organelle fusion; GO:0048489 synaptic vesicle transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090161 Golgi ribbon formation; GO:0090174 organelle membrane fusion; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering;","GO:0000139 Golgi membrane; GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031224 intrinsic component of membrane; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex;","GO:0000149 SNARE binding; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019905 syntaxin binding;","PF00804","PF00804 Syntaxin","U","KOG0809","SNARE protein TLG2/Syntaxin 16","WP2858 ECTODERM DIFFERENTIATION","http://www.wikipathways.org/instance/WP2858_r116763",null,"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811438 Intra-Golgi traffic;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811438;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442","PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O14672","Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ADAM10 PE=1 SV=1","ADAM10",1.54715046,{"v":3.66739e-05,"d":"3.67E-05"},"up",38557.4,38340.7,40592.8,59491.2,61980.9,60304,0.773036787,0.768692171,0.813844493,1.192738257,1.242654218,1.209034073,"plasma membrane","K06704","ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]","hsa05120 Epithelial cell signaling in Helicobacter pylori infection; hsa05010 Alzheimer disease","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001558 regulation of cell growth; GO:0001655 urogenital system development; GO:0001667 ameboidal-type cell migration; GO:0001701 in utero embryonic development; GO:0001708 cell fate specification; GO:0001709 cell fate determination; GO:0001775 cell activation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002685 regulation of leukocyte migration; GO:0002687 positive regulation of leukocyte migration; GO:0002688 regulation of leukocyte chemotaxis; GO:0002690 positive regulation of leukocyte chemotaxis; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0003006 developmental process involved in reproduction; GO:0003007 heart morphogenesis; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006508 proteolysis; GO:0006509 membrane protein ectodomain proteolysis; GO:0006518 peptide metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006913 nucleocytoplasmic transport; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006955 immune response; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007220 Notch receptor processing; GO:0007229 integrin-mediated signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007400 neuroblast fate determination; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007419 ventral cord development; GO:0007507 heart development; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0007548 sex differentiation; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008347 glial cell migration; GO:0008361 regulation of cell size; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010453 regulation of cell fate commitment; GO:0010467 gene expression; GO:0010470 regulation of gastrulation; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010819 regulation of T cell chemotaxis; GO:0010820 positive regulation of T cell chemotaxis; GO:0010975 regulation of neuron projection development; GO:0014016 neuroblast differentiation; GO:0014017 neuroblast fate commitment; GO:0014706 striated muscle tissue development; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0016485 protein processing; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022617 extracellular matrix disassembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030182 neuron differentiation; GO:0030198 extracellular matrix organization; GO:0030307 positive regulation of cell growth; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway; GO:0030516 regulation of axon extension; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031293 membrane protein intracellular domain proteolysis; GO:0031344 regulation of cell projection organization; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033619 membrane protein proteolysis; GO:0034097 response to cytokine; GO:0034205 amyloid-beta formation; GO:0034612 response to tumor necrosis factor; GO:0034641 cellular nitrogen compound metabolic process; GO:0035051 cardiocyte differentiation; GO:0035333 Notch receptor processing"," ligand-dependent; GO:0035386 regulation of Roundabout signaling pathway; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0040025 vulval development; GO:0042063 gliogenesis; GO:0042117 monocyte activation; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042659 regulation of cell fate specification; GO:0042661 regulation of mesodermal cell fate specification; GO:0042982 amyloid precursor protein metabolic process; GO:0042987 amyloid precursor protein catabolic process; GO:0043009 chordate embryonic development; GO:0043062 extracellular structure organization; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043603 cellular amide metabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045138 nematode male tail tip morphogenesis; GO:0045165 cell fate commitment; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045670 regulation of osteoclast differentiation; GO:0045927 positive regulation of growth; GO:0045995 regulation of embryonic development; GO:0046661 male sex differentiation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048542 lymph gland development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048732 gland development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048863 stem cell differentiation; GO:0048865 stem cell fate commitment; GO:0048867 stem cell fate determination; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050435 amyloid-beta metabolic process; GO:0050767 regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0050920 regulation of chemotaxis; GO:0050921 positive regulation of chemotaxis; GO:0051089 constitutive protein ectodomain proteolysis; GO:0051128 regulation of cellular component organization; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051604 protein maturation; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060537 muscle tissue development; GO:0060538 skeletal muscle organ development; GO:0061061 muscle structure development; GO:0061318 renal filtration cell differentiation; GO:0061319 nephrocyte differentiation; GO:0061320 pericardial nephrocyte differentiation; GO:0061387 regulation of extent of cell growth; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072001 renal system development; GO:0072359 circulatory system development; GO:0090066 regulation of anatomical structure size; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090598 male anatomical structure morphogenesis; GO:0097485 neuron projection guidance; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140131 positive regulation of lymphocyte chemotaxis; GO:1901564 organonitrogen compound metabolic process; GO:1901623 regulation of lymphocyte chemotaxis; GO:1902105 regulation of leukocyte differentiation; GO:1902667 regulation of axon guidance; GO:1903706 regulation of hemopoiesis; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus; GO:1905770 regulation of mesodermal cell differentiation; GO:1905902 regulation of mesoderm formation; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000380 regulation of mesoderm development; GO:2000401 regulation of lymphocyte migration; GO:2000403 positive regulation of lymphocyte migration; GO:2000404 regulation of T cell migration; GO:2000406 positive regulation of T cell migration;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005802 trans-Golgi network; GO:0005886 plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030425 dendrite; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032279 asymmetric synapse; GO:0035579 specific granule membrane; GO:0036477 somatodendritic compartment; GO:0042581 specific granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044309 neuron spine; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0070820 tertiary granule; GO:0070821 tertiary granule membrane; GO:0071944 cell periphery; GO:0097038 perinuclear endoplasmic reticulum; GO:0097060 synaptic membrane; GO:0097197 tetraspanin-enriched microdomain; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099503 secretory vesicle; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004222 metalloendopeptidase activity; GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008237 metallopeptidase activity; GO:0016787 hydrolase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0042169 SH2 domain binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0050839 cell adhesion molecule binding; GO:0140096 catalytic activity"," acting on a protein;","PF13574; PF00200","PF13574 Metallo-peptidase family M12B Reprolysin-like; PF00200 Disintegrin","W","KOG3658","Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases","WP4906 3Q29 COPY NUMBER VARIATION SYNDROME;WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP3845 CANONICAL AND NONCANONICAL NOTCH SIGNALING;WP3286 COPPER HOMEOSTASIS;WP516 HYPERTROPHY MODEL;WP5092 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4906_r115773;http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP3845_r116460;http://www.wikipathways.org/instance/WP3286_r106367;http://www.wikipathways.org/instance/WP516_r117755;http://www.wikipathways.org/instance/WP5092_r119997;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1266738 Developmental Biology;R-HSA-1442490 Collagen degradation;R-HSA-1474228 Degradation of the extracellular matrix;R-HSA-1474244 Extracellular matrix organization;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-177929 Signaling by EGFR;R-HSA-1980143 Signaling by NOTCH1;R-HSA-1980145 Signaling by NOTCH2;R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus;R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer;R-HSA-2644603 Signaling by NOTCH1 in Cancer;R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants;R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer;R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants;R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer;R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus;R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);R-HSA-392499 Metabolism of proteins;R-HSA-3928665 EPH-ephrin mediated repulsion of cells;R-HSA-422475 Axon guidance;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-8957275 Post-translational protein phosphorylation;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012852 Signaling by NOTCH3;R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus;R-HSA-9675108 Nervous system development;R-HSA-977225 Amyloid fiber formation","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1442490;https://reactome.org/PathwayBrowser/#/R-HSA-1474228;https://reactome.org/PathwayBrowser/#/R-HSA-1474244;https://reactome.org/PathwayBrowser/#/R-HSA-157118;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-177929;https://reactome.org/PathwayBrowser/#/R-HSA-1980143;https://reactome.org/PathwayBrowser/#/R-HSA-1980145;https://reactome.org/PathwayBrowser/#/R-HSA-2122948;https://reactome.org/PathwayBrowser/#/R-HSA-2644602;https://reactome.org/PathwayBrowser/#/R-HSA-2644603;https://reactome.org/PathwayBrowser/#/R-HSA-2644606;https://reactome.org/PathwayBrowser/#/R-HSA-2660825;https://reactome.org/PathwayBrowser/#/R-HSA-2660826;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-2691230;https://reactome.org/PathwayBrowser/#/R-HSA-2691232;https://reactome.org/PathwayBrowser/#/R-HSA-2894858;https://reactome.org/PathwayBrowser/#/R-HSA-2894862;https://reactome.org/PathwayBrowser/#/R-HSA-2979096;https://reactome.org/PathwayBrowser/#/R-HSA-381426;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-3928665;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-8957275;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012852;https://reactome.org/PathwayBrowser/#/R-HSA-9013507;https://reactome.org/PathwayBrowser/#/R-HSA-9013694;https://reactome.org/PathwayBrowser/#/R-HSA-9013700;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-977225","APICAL SURFACE;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_SURFACE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O14681","Etoposide-induced protein 2.4 homolog OS=Homo sapiens OX=9606 GN=EI24 PE=1 SV=4","EI24",0.959512126,0.371613447,"nochange",23947.6,26098.5,23440.1,23188,24603.4,22719.5,0.997836762,1.0874594,0.976690503,0.966186125,1.025162312,0.946664898,"plasma membrane","K10134","EI24; etoposide-induced 2.4 mRNA","hsa04115 p53 signaling pathway","GO:0001558 regulation of cell growth; GO:0003008 system process; GO:0006914 autophagy; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009056 catabolic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010225 response to UV-C; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0016236 macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016242 negative regulation of macroautophagy; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030308 negative regulation of cell growth; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033554 cellular response to stress; GO:0034644 cellular response to UV; GO:0035556 intracellular signal transduction; GO:0040008 regulation of growth; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042308 negative regulation of protein import into nucleus; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0044087 regulation of cellular component biogenesis; GO:0044088 regulation of vacuole organization; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0045926 negative regulation of growth; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046823 negative regulation of nucleocytoplasmic transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050885 neuromuscular process controlling balance; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051716 cellular response to stimulus; GO:0060341 regulation of cellular localization; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071494 cellular response to UV-C; GO:0090087 regulation of peptide transport; GO:0090317 negative regulation of intracellular protein transport; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0104004 cellular response to environmental stimulus; GO:1900180 regulation of protein localization to nucleus; GO:1900181 negative regulation of protein localization to nucleus; GO:1901416 regulation of response to ethanol; GO:1901418 positive regulation of response to ethanol; GO:1901419 regulation of response to alcohol; GO:1901421 positive regulation of response to alcohol; GO:1902115 regulation of organelle assembly; GO:1902116 negative regulation of organelle assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902902 negative regulation of autophagosome assembly; GO:1903828 negative regulation of protein localization; GO:1904589 regulation of protein import; GO:1904590 negative regulation of protein import; GO:1904950 negative regulation of establishment of protein localization; GO:2000785 regulation of autophagosome assembly; GO:2001023 regulation of response to drug; GO:2001025 positive regulation of response to drug; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"TV","KOG3966","p53-mediated apoptosis protein EI24/PIG8","WP3982 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER","http://www.wikipathways.org/instance/WP3982_r108115",{"$nulls":3},"P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O14686","Histone-lysine N-methyltransferase 2D OS=Homo sapiens OX=9606 GN=KMT2D PE=1 SV=2","KMT2D",0.825564384,0.002619685,"down",8059.35,7400.21,7643.52,6326.63,6218.19,6528.26,1.146526853,1.052757292,1.087370685,0.900029306,0.884602581,0.928713283,"nucleus","K09187","MLL2; [histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]","hsa00310 Lysine degradation; hsa04934 Cushing syndrome; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0001555 oocyte growth; GO:0001654 eye development; GO:0001701 in utero embryonic development; GO:0001745 compound eye morphogenesis; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002682 regulation of immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007389 pattern specification process; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007458 progression of morphogenetic furrow involved in compound eye morphogenesis; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007591 molting cycle"," chitin-based cuticle; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008284 positive regulation of cell population proliferation; GO:0008586 imaginal disc-derived wing vein morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0018022 peptidyl-lysine methylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018990 ecdysis"," chitin-based cuticle; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022404 molting cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031062 positive regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway; GO:0033146 regulation of intracellular estrogen receptor signaling pathway; GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway; GO:0033993 response to lipid; GO:0034968 histone lysine methylation; GO:0035075 response to ecdysone; GO:0035076 ecdysone receptor-mediated signaling pathway; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036211 protein modification process; GO:0036314 response to sterol; GO:0036315 cellular response to sterol; GO:0040007 growth; GO:0040028 regulation of vulval development; GO:0040029 regulation of gene expression"," epigenetic; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042303 molting cycle; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043627 response to estrogen; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045652 regulation of megakaryocyte differentiation; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048580 regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048592 eye morphogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051568 histone H3-K4 methylation; GO:0051570 regulation of histone H3-K9 methylation; GO:0051574 positive regulation of histone H3-K9 methylation; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061062 regulation of nematode larval development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071390 cellular response to ecdysone; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090596 sensory organ morphogenesis; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:1900112 regulation of histone H3-K9 trimethylation; GO:1900114 positive regulation of histone H3-K9 trimethylation; GO:1901564 organonitrogen compound metabolic process; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1904837 beta-catenin-TCF complex assembly; GO:1905269 positive regulation of chromatin organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0008230 ecdysone receptor holocomplex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043235 receptor complex; GO:0044666 MLL3/4 complex; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008270 zinc ion binding; GO:0008276 protein methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016278 lysine N-methyltransferase activity; GO:0016279 protein-lysine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0018024 histone-lysine N-methyltransferase activity; GO:0030374 nuclear receptor coactivator activity; GO:0042054 histone methyltransferase activity; GO:0042393 histone binding; GO:0042800 histone methyltransferase activity (H3-K4 specific); GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF13771; PF00628; PF13832","PF13771 PHD-like zinc-binding domain; PF00628 PHD-finger; PF13832 PHD-zinc-finger like domain","R","KOG4443","Putative transcription factor HALR/MLL3"," involved in embryonic development","WP4949 16P112 PROXIMAL DELETION SYNDROME;WP2369 HISTONE MODIFICATIONS","http://www.wikipathways.org/instance/WP4949_r115778;http://www.wikipathways.org/instance/WP2369_r118380","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex;R-HSA-212436 Generic Transcription Pathway;R-HSA-3214841 PKMTs methylate histone lysines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-3769402 Deactivation of the beta-catenin transactivating complex;R-HSA-4839726 Chromatin organization;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-201681;https://reactome.org/PathwayBrowser/#/R-HSA-201722;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3214841;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-3769402;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5617472;https://reactome.org/PathwayBrowser/#/R-HSA-5619507;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8936459","KRAS SIGNALING DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_DN"]
["O14713","Integrin beta-1-binding protein 1 OS=Homo sapiens OX=9606 GN=ITGB1BP1 PE=1 SV=1","ITGB1BP1",0.801634847,0.673062677,"nochange",1800.5,632.668,1274.58,1268.79,792.61,910.86,1.617213632,0.56826399,1.144830964,1.139630372,0.711924297,0.818136745,"nucleus","K20058",null,null,"GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001935 endothelial cell proliferation; GO:0001944 vasculature development; GO:0001952 regulation of cell-matrix adhesion; GO:0001953 negative regulation of cell-matrix adhesion; GO:0001954 positive regulation of cell-matrix adhesion; GO:0002040 sprouting angiogenesis; GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006469 negative regulation of protein kinase activity; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006929 substrate-dependent cell migration; GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007275 multicellular organism development; GO:0008015 blood circulation; GO:0008104 protein localization; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008593 regulation of Notch signaling pathway; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010596 negative regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010633 negative regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010762 regulation of fibroblast migration; GO:0010764 negative regulation of fibroblast migration; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0014812 muscle cell migration; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0016525 negative regulation of angiogenesis; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031589 cell-substrate adhesion; GO:0032091 negative regulation of protein binding; GO:0032147 activation of protein kinase activity; GO:0032148 activation of protein kinase B activity; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033622 integrin activation; GO:0033628 regulation of cell adhesion mediated by integrin; GO:0033673 negative regulation of kinase activity; GO:0033674 positive regulation of kinase activity; GO:0034613 cellular protein localization; GO:0035148 tube formation; GO:0035150 regulation of tube size; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0035924 cellular response to vascular endothelial growth factor stimulus; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043113 receptor clustering; GO:0043393 regulation of protein binding; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0043537 negative regulation of blood vessel endothelial cell migration; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045747 positive regulation of Notch signaling pathway; GO:0045765 regulation of angiogenesis; GO:0045785 positive regulation of cell adhesion; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050673 epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051451 myoblast migration; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051496 positive regulation of stress fiber assembly; GO:0051641 cellular localization; GO:0051668 localization within membrane; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051893 regulation of focal adhesion assembly; GO:0051894 positive regulation of focal adhesion assembly; GO:0051895 negative regulation of focal adhesion assembly; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070373 negative regulation of ERK1 and ERK2 cascade; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071774 response to fibroblast growth factor; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0090049 regulation of cell migration involved in sprouting angiogenesis; GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090109 regulation of cell-substrate junction assembly; GO:0090313 regulation of protein targeting to membrane; GO:0090314 positive regulation of protein targeting to membrane; GO:0090315 negative regulation of protein targeting to membrane; GO:0090316 positive regulation of intracellular protein transport; GO:0090317 negative regulation of intracellular protein transport; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:1900024 regulation of substrate adhesion-dependent cell spreading; GO:1900025 negative regulation of substrate adhesion-dependent cell spreading; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901888 regulation of cell junction assembly; GO:1901889 negative regulation of cell junction assembly; GO:1901890 positive regulation of cell junction assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903391 regulation of adherens junction organization; GO:1903392 negative regulation of adherens junction organization; GO:1903393 positive regulation of adherens junction organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903533 regulation of protein targeting; GO:1903670 regulation of sprouting angiogenesis; GO:1903671 negative regulation of sprouting angiogenesis; GO:1903828 negative regulation of protein localization; GO:1903829 positive regulation of protein localization; GO:1904950 negative regulation of establishment of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905476 negative regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2001044 regulation of integrin-mediated signaling pathway; GO:2001141 regulation of RNA biosynthetic process;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016604 nuclear body; GO:0030027 lamellipodium; GO:0031252 cell leading edge; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0120025 plasma membrane bounded cell projection;","GO:0005092 GDP-dissociation inhibitor activity; GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0044877 protein-containing complex binding; GO:0050839 cell adhesion molecule binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF10480","PF10480 Beta-1 integrin binding protein",{"$nulls":8},"PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["O14717","tRNA (cytosine(38)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=TRDMT1 PE=1 SV=1","TRDMT1",0.647581496,0.233005139,"nochange",1200.36,1538.99,2102.9,"NA",748.191,1342.31,0.865716943,1.109941782,1.516641806,"NA",0.539606139,0.96809333,"cytoskeleton","K15336",null,null,"GO:0000723 telomere maintenance; GO:0001510 RNA methylation; GO:0001975 response to amphetamine; GO:0002230 positive regulation of defense response to virus by host; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006304 DNA modification; GO:0006305 DNA alkylation; GO:0006306 DNA methylation; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006400 tRNA modification; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009410 response to xenobiotic stimulus; GO:0009451 RNA modification; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009790 embryo development; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0014075 response to amine; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0019222 regulation of metabolic process; GO:0030488 tRNA methylation; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032200 telomere organization; GO:0032259 methylation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032776 DNA methylation on cytosine; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0043045 DNA methylation involved in embryo development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044728 DNA methylation or demethylation; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050688 regulation of defense response to virus; GO:0050691 regulation of defense response to virus by host; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051276 chromosome organization; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080134 regulation of response to stress; GO:0090116 C-5 methylation of cytosine; GO:0090304 nucleic acid metabolic process; GO:0097366 response to bronchodilator; GO:1901360 organic cyclic compound metabolic process; GO:1901538 changes to DNA methylation involved in embryo development; GO:1901698 response to nitrogen compound;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0010494 cytoplasmic stress granule; GO:0016363 nuclear matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003824 catalytic activity; GO:0003886 DNA (cytosine-5-)-methyltransferase activity; GO:0008168 methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008175 tRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0009008 DNA-methyltransferase activity; GO:0016427 tRNA (cytosine) methyltransferase activity; GO:0016428 tRNA (cytosine-5-)-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0140097 catalytic activity"," acting on DNA; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF00145","PF00145 C-5 cytosine-specific DNA methylase","K","KOG0919","C-5 cytosine-specific DNA methylase",{"$nulls":3},"R-HSA-6782315 tRNA modification in the nucleus and cytosol;R-HSA-72306 tRNA processing;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6782315;https://reactome.org/PathwayBrowser/#/R-HSA-72306;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O14727","Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2","APAF1",1.054656356,0.211538701,"nochange",9947.28,9928.57,10249.1,11146.2,9935.77,10689.5,0.964250921,0.962437246,0.993508187,1.080469597,0.963135186,1.036198863,"cytoplasm","K02084","APAF1; apoptotic protease-activating factor","hsa05160 Hepatitis C; hsa05161 Hepatitis B; hsa05200 Pathways in cancer; hsa05169 Epstein-Barr virus infection; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05168 Herpes simplex virus 1 infection; hsa04210 Apoptosis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa04215 Apoptosis - multiple species; hsa05134 Legionellosis; hsa05152 Tuberculosis; hsa05162 Measles; hsa04115 p53 signaling pathway; hsa05016 Huntington disease; hsa05164 Influenza A; hsa05222 Small cell lung cancer; hsa01524 Platinum drug resistance; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa05417 Lipid and atherosclerosis","GO:0001666 response to hypoxia; GO:0001775 cell activation; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0002009 morphogenesis of an epithelium; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006915 apoptotic process; GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0006950 response to stress; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007568 aging; GO:0007584 response to nutrient; GO:0008219 cell death; GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010657 muscle cell apoptotic process; GO:0010658 striated muscle cell apoptotic process; GO:0010659 cardiac muscle cell apoptotic process; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0014020 primary neural tube formation; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016331 morphogenesis of embryonic epithelium; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0021915 neural tube development; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030900 forebrain development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031667 response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033554 cellular response to stress; GO:0034349 glial cell apoptotic process; GO:0034976 response to endoplasmic reticulum stress; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036230 granulocyte activation; GO:0036293 response to decreased oxygen levels; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045786 negative regulation of cell cycle; GO:0045862 positive regulation of proteolysis; GO:0046903 secretion; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051402 neuron apoptotic process; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; GO:0070316 regulation of G0 to G1 transition; GO:0070317 negative regulation of G0 to G1 transition; GO:0070482 response to oxygen levels; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0070997 neuron death; GO:0071216 cellular response to biotic stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0071840 cellular component organization or biogenesis; GO:0072175 epithelial tube formation; GO:0072396 response to cell cycle checkpoint signaling; GO:0072402 response to DNA integrity checkpoint signaling; GO:0072414 response to mitotic cell cycle checkpoint signaling; GO:0072423 response to DNA damage checkpoint signaling; GO:0072432 response to G1 DNA damage checkpoint signaling; GO:0080090 regulation of primary metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:1900117 regulation of execution phase of apoptosis; GO:1902510 regulation of apoptotic DNA fragmentation; GO:1903624 regulation of DNA catabolic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043293 apoptosome; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen;","GO:0000166 nucleotide binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process; GO:0016504 peptidase activator activity; GO:0016505 peptidase activator activity involved in apoptotic process; GO:0030234 enzyme regulator activity; GO:0031072 heat shock protein binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process; GO:0061134 peptidase regulator activity; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00619; PF00931; PF17908","PF00619 Caspase recruitment domain; PF00931 NB-ARC domain; PF17908 APAF-1 helical domain","T","KOG4658","Apoptotic ATPase","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP2447 AMYOTROPHIC LATERAL SCLEROSIS ALS;WP254 APOPTOSIS;WP1772 APOPTOSIS MODULATION AND SIGNALING;WP384 APOPTOSIS MODULATION BY HSP70;WP5090 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY;WP707 DNA DAMAGE RESPONSE;WP3959 DNA IRDOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM;WP314 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS;WP4666 HEPATITIS B INFECTION;WP4864 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS;WP4630 MEASLES VIRUS INFECTION;WP1530 MIRNA REGULATION OF DNA DAMAGE RESPONSE;WP3982 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER;WP2507 NANOMATERIAL INDUCED APOPTOSIS;WP3941 OXIDATIVE DAMAGE RESPONSE;WP4963 P53 TRANSCRIPTIONAL GENE NETWORK;WP2371 PARKINSONS DISEASE PATHWAY;WP4838 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS;WP4658 SMALL CELL LUNG CANCER;WP231 TNFALPHA SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP2447_r113794;http://www.wikipathways.org/instance/WP254_r118382;http://www.wikipathways.org/instance/WP1772_r120736;http://www.wikipathways.org/instance/WP384_r119819;http://www.wikipathways.org/instance/WP5090_r118898;http://www.wikipathways.org/instance/WP707_r116541;http://www.wikipathways.org/instance/WP3959_r118468;http://www.wikipathways.org/instance/WP314_r116694;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP4864_r116596;http://www.wikipathways.org/instance/WP4630_r120771;http://www.wikipathways.org/instance/WP1530_r118120;http://www.wikipathways.org/instance/WP3982_r108115;http://www.wikipathways.org/instance/WP2507_r110715;http://www.wikipathways.org/instance/WP3941_r117040;http://www.wikipathways.org/instance/WP4963_r112233;http://www.wikipathways.org/instance/WP2371_r119919;http://www.wikipathways.org/instance/WP4838_r110282;http://www.wikipathways.org/instance/WP4658_r119261;http://www.wikipathways.org/instance/WP231_r120699",null,"R-HSA-109581 Apoptosis;R-HSA-109606 Intrinsic Pathway for Apoptosis;R-HSA-111458 Formation of apoptosome;R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage;R-HSA-111461 Cytochrome c-mediated apoptotic response;R-HSA-111463 SMAC (DIABLO) binds to IAPs ;R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ;R-HSA-111469 SMAC"," XIAP-regulated apoptotic response;R-HSA-111471 Apoptotic factor-mediated response;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5357801 Programmed Cell Death;R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes;R-HSA-6798695 Neutrophil degranulation;R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953750 Transcriptional Regulation by E2F6;R-HSA-9627069 Regulation of the apoptosome activity","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-109606;https://reactome.org/PathwayBrowser/#/R-HSA-111458;https://reactome.org/PathwayBrowser/#/R-HSA-111459;https://reactome.org/PathwayBrowser/#/R-HSA-111461;https://reactome.org/PathwayBrowser/#/R-HSA-111463;https://reactome.org/PathwayBrowser/#/R-HSA-111464;https://reactome.org/PathwayBrowser/#/R-HSA-111469;https://reactome.org/PathwayBrowser/#/R-HSA-111471;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-5633008;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-6803207;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953750;https://reactome.org/PathwayBrowser/#/R-HSA-9627069","P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O14730","Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2","RIOK3",0.815755628,0.046873442,"nochange",12985.2,13884.7,14260.8,10764.9,10108.3,12679.4,1.043221175,1.115486327,1.145701917,0.864843948,0.812093199,1.018653434,"cytoplasm","K08872",null,null,"GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002698 negative regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007059 chromosome segregation; GO:0008152 metabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0014070 response to organic cyclic compound; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0016310 phosphorylation; GO:0019538 protein metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030490 maturation of SSU-rRNA; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031349 positive regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032459 regulation of protein oligomerization; GO:0032460 negative regulation of protein oligomerization; GO:0032462 regulation of protein homooligomerization; GO:0032463 negative regulation of protein homooligomerization; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032648 regulation of interferon-beta production; GO:0032728 positive regulation of interferon-beta production; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0036211 protein modification process; GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; GO:0039533 regulation of MDA-5 signaling pathway; GO:0039534 negative regulation of MDA-5 signaling pathway; GO:0042221 response to chemical; GO:0042254 ribosome biogenesis; GO:0042274 ribosomal small subunit biogenesis; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043254 regulation of protein-containing complex assembly; GO:0043331 response to dsRNA; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050687 negative regulation of defense response to virus; GO:0050688 regulation of defense response to virus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071359 cellular response to dsRNA; GO:0071407 cellular response to organic cyclic compound; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:0098586 cellular response to virus; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1990784 response to dsDNA; GO:1990786 cellular response to dsDNA;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030684 preribosome; GO:0030688 preribosome"," small subunit precursor; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1990904 ribonucleoprotein complex;","GO:0002020 protease binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0089720 caspase binding; GO:0140096 catalytic activity"," acting on a protein;",null,null,"T","KOG2269","Serine/threonine protein kinase","WP2849 HEMATOPOIETIC STEM CELL DIFFERENTIATION","http://www.wikipathways.org/instance/WP2849_r117150",null,"R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","ADIPOGENESIS;HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O14733","Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2","MAP2K7",1.449876028,0.000550947,"up",9755.1,8618.4,8951.25,13338.1,13078.4,13201,0.874344678,0.772462832,0.802296009,1.195487155,1.172210375,1.183198951,"cytoplasm","K04431","MAP2K7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]","hsa04380 Osteoclast differentiation; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05161 Hepatitis B; hsa05170 Human immunodeficiency virus 1 infection; hsa05169 Epstein-Barr virus infection; hsa05418 Fluid shear stress and atherosclerosis; hsa05010 Alzheimer disease; hsa05132 Salmonella infection; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa04012 ErbB signaling pathway; hsa04660 T cell receptor signaling pathway; hsa05135 Yersinia infection; hsa04141 Protein processing in endoplasmic reticulum; hsa04010 MAPK signaling pathway; hsa04936 Alcoholic liver disease; hsa04926 Relaxin signaling pathway; hsa04664 Fc epsilon RI signaling pathway; hsa05016 Huntington disease; hsa04668 TNF signaling pathway; hsa04530 Tight junction; hsa04912 GnRH signaling pathway; hsa04722 Neurotrophin signaling pathway; hsa04620 Toll-like receptor signaling pathway; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa05417 Lipid and atherosclerosis","GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0000280 nuclear division; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001558 regulation of cell growth; GO:0001667 ameboidal-type cell migration; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002165 instar larval or pupal development; GO:0002237 response to molecule of bacterial origin; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006582 melanin metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006911 phagocytosis"," engulfment; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006970 response to osmotic stress; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007140 male meiotic nuclear division; GO:0007154 cell communication; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0007391 dorsal closure; GO:0007395 dorsal closure"," spreading of leading edge cells; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007444 imaginal disc development; GO:0007483 genital disc morphogenesis; GO:0007484 imaginal disc-derived genitalia development; GO:0007485 imaginal disc-derived male genitalia development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007561 imaginal disc eversion; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0008361 regulation of cell size; GO:0009266 response to temperature stimulus; GO:0009314 response to radiation; GO:0009408 response to heat; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009611 response to wounding; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009743 response to carbohydrate; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010259 multicellular organism aging; GO:0010324 membrane invagination; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010591 regulation of lamellipodium assembly; GO:0010592 positive regulation of lamellipodium assembly; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0018958 phenol-containing compound metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019748 secondary metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030198 extracellular matrix organization; GO:0030307 positive regulation of cell growth; GO:0030381 chorion-containing eggshell pattern formation; GO:0030516 regulation of axon extension; GO:0030539 male genitalia development; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031099 regeneration; GO:0031102 neuron projection regeneration; GO:0031103 axon regeneration; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032204 regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032212 positive regulation of telomere maintenance via telomerase; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034612 response to tumor necrosis factor; GO:0034769 basement membrane disassembly; GO:0035006 melanization defense response; GO:0035112 genitalia morphogenesis; GO:0035126 post-embryonic genitalia morphogenesis; GO:0035215 genital disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0036335 intestinal stem cell homeostasis; GO:0040007 growth; GO:0040008 regulation of growth; GO:0040009 regulation of growth rate; GO:0040011 locomotion; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042440 pigment metabolic process; GO:0042592 homeostatic process; GO:0042594 response to starvation; GO:0042981 regulation of apoptotic process; GO:0043062 extracellular structure organization; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043277 apoptotic cell clearance; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043523 regulation of neuron apoptotic process; GO:0043525 positive regulation of neuron apoptotic process; GO:0043549 regulation of kinase activity; GO:0043652 engulfment of apoptotic cell; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045087 innate immune response; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045610 regulation of hemocyte differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045773 positive regulation of axon extension; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046528 imaginal disc fusion; GO:0046529 imaginal disc fusion"," thorax closure; GO:0046661 male sex differentiation; GO:0046685 response to arsenic-containing substance; GO:0046686 response to cadmium ion; GO:0046688 response to copper ion; GO:0046843 dorsal appendage formation; GO:0046844 chorion micropyle formation; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048599 oocyte development; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048678 response to axon injury; GO:0048679 regulation of axon regeneration; GO:0048680 positive regulation of axon regeneration; GO:0048686 regulation of sprouting of injured axon; GO:0048687 positive regulation of sprouting of injured axon; GO:0048690 regulation of axon extension involved in regeneration; GO:0048691 positive regulation of axon extension involved in regeneration; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048803 imaginal disc-derived male genitalia morphogenesis; GO:0048805 imaginal disc-derived genitalia morphogenesis; GO:0048806 genitalia development; GO:0048808 male genitalia morphogenesis; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048872 homeostasis of number of cells; GO:0048878 chemical homeostasis; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051321 meiotic cell cycle; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051972 regulation of telomerase activity; GO:0051973 positive regulation of telomerase activity; GO:0055088 lipid homeostasis; GO:0055090 acylglycerol homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0061024 membrane organization; GO:0061387 regulation of extent of cell growth; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070328 triglyceride homeostasis; GO:0070555 response to interleukin-1; GO:0070570 regulation of neuron projection regeneration; GO:0070572 positive regulation of neuron projection regeneration; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071241 cellular response to inorganic substance; GO:0071243 cellular response to arsenic-containing substance; GO:0071248 cellular response to metal ion; GO:0071276 cellular response to cadmium ion; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071396 cellular response to lipid; GO:0071704 organic substance metabolic process; GO:0071711 basement membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072708 response to sorbitol; GO:0072709 cellular response to sorbitol; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090598 male anatomical structure morphogenesis; GO:0097485 neuron projection guidance; GO:0097501 stress response to metal ion; GO:0098657 import into cell; GO:0099024 plasma membrane invagination; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140013 meiotic nuclear division; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902743 regulation of lamellipodium organization; GO:1902745 positive regulation of lamellipodium organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903046 meiotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904353 regulation of telomere capping; GO:1904355 positive regulation of telomere capping; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904358 positive regulation of telomere maintenance via telomere lengthening; GO:1990138 neuron projection extension; GO:1990169 stress response to copper ion; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000573 positive regulation of DNA biosynthetic process; GO:2000671 regulation of motor neuron apoptotic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030424 axon; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004707 MAP kinase activity; GO:0004708 MAP kinase kinase activity; GO:0004712 protein serine/threonine/tyrosine kinase activity; GO:0005078 MAP-kinase scaffold activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008022 protein C-terminus binding; GO:0008545 JUN kinase kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0019904 protein domain specific binding; GO:0030554 adenyl nucleotide binding; GO:0031435 mitogen-activated protein kinase kinase kinase binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035591 signaling adaptor activity; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042169 SH2 domain binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0060090 molecular adaptor activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00069","PF00069 Protein kinase domain","T","KOG0983","Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP2795 CARDIAC HYPERTROPHIC RESPONSE;WP673 ERBB SIGNALING PATHWAY;WP3853 ERK PATHWAY IN HUNTINGTONS DISEASE;WP2261 GLIOBLASTOMA SIGNALING PATHWAYS;WP4666 HEPATITIS B INFECTION;WP4877 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING;WP4754 IL18 SIGNALING PATHWAY;WP195 IL1 SIGNALING PATHWAY;WP481 INSULIN SIGNALING;WP2637 INTERLEUKIN1 IL1 STRUCTURAL PATHWAY;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP422 MAPK CASCADE;WP382 MAPK SIGNALING PATHWAY;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP3611 PHOTODYNAMIC THERAPYINDUCED AP1 SURVIVAL SIGNALING;WP2018 RANKLRANK SIGNALING PATHWAY;WP3863 TCELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION;WP231 TNFALPHA SIGNALING PATHWAY;WP75 TOLLLIKE RECEPTOR SIGNALING PATHWAY;WP4566 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP2795_r117670;http://www.wikipathways.org/instance/WP673_r118930;http://www.wikipathways.org/instance/WP3853_r120593;http://www.wikipathways.org/instance/WP2261_r118379;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP4877_r119237;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP195_r120702;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP2637_r117962;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP422_r116723;http://www.wikipathways.org/instance/WP382_r119087;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP3611_r120501;http://www.wikipathways.org/instance/WP2018_r120672;http://www.wikipathways.org/instance/WP3863_r120420;http://www.wikipathways.org/instance/WP231_r120699;http://www.wikipathways.org/instance/WP75_r119233;http://www.wikipathways.org/instance/WP4566_r104315;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559583 Cellular Senescence;R-HSA-2871796 FCERI mediated MAPK activation;R-HSA-448424 Interleukin-17 signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450294 MAP kinase activation;R-HSA-450321 JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;R-HSA-5210891 Uptake and function of anthrax toxins;R-HSA-5339562 Uptake and actions of bacterial toxins;R-HSA-5663205 Infectious disease;R-HSA-8953897 Cellular responses to stimuli;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-975871 MyD88 cascade initiated on plasma membrane","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-166016;https://reactome.org/PathwayBrowser/#/R-HSA-166058;https://reactome.org/PathwayBrowser/#/R-HSA-166166;https://reactome.org/PathwayBrowser/#/R-HSA-168138;https://reactome.org/PathwayBrowser/#/R-HSA-168142;https://reactome.org/PathwayBrowser/#/R-HSA-168164;https://reactome.org/PathwayBrowser/#/R-HSA-168176;https://reactome.org/PathwayBrowser/#/R-HSA-168179;https://reactome.org/PathwayBrowser/#/R-HSA-168181;https://reactome.org/PathwayBrowser/#/R-HSA-168188;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168898;https://reactome.org/PathwayBrowser/#/R-HSA-181438;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2454202;https://reactome.org/PathwayBrowser/#/R-HSA-2559580;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-2871796;https://reactome.org/PathwayBrowser/#/R-HSA-448424;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-450294;https://reactome.org/PathwayBrowser/#/R-HSA-450321;https://reactome.org/PathwayBrowser/#/R-HSA-5210891;https://reactome.org/PathwayBrowser/#/R-HSA-5339562;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-937061;https://reactome.org/PathwayBrowser/#/R-HSA-975138;https://reactome.org/PathwayBrowser/#/R-HSA-975155;https://reactome.org/PathwayBrowser/#/R-HSA-975871"]
["O14734","Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1","ACOT8",0.747014555,0.000650461,"down",24465.1,23272.5,22369.2,17423.1,17002.5,17945.2,1.198509768,1.140086024,1.095834667,0.853532401,0.832927817,0.879109323,"cytoplasm","K11992","ACOT8; acyl-CoA thioesterase 8 [EC:3.1.2.27]","hsa00120 Primary bile acid biosynthesis; hsa04146 Peroxisome; hsa01100 Metabolic pathways","GO:0001676 long-chain fatty acid metabolic process; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006637 acyl-CoA metabolic process; GO:0006694 steroid biosynthetic process; GO:0006699 bile acid biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008206 bile acid metabolic process; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009062 fatty acid catabolic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010561 negative regulation of glycoprotein biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0016054 organic acid catabolic process; GO:0016559 peroxisome fission; GO:0019222 regulation of metabolic process; GO:0019395 fatty acid oxidation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0030258 lipid modification; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase; GO:0033559 unsaturated fatty acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034440 lipid oxidation; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035383 thioester metabolic process; GO:0036109 alpha-linolenic acid metabolic process; GO:0042886 amide transport; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0043603 cellular amide metabolic process; GO:0043648 dicarboxylic acid metabolic process; GO:0043649 dicarboxylic acid catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0045184 establishment of protein localization; GO:0045223 regulation of CD4 production; GO:0045225 negative regulation of CD4 production; GO:0046394 carboxylic acid biosynthetic process; GO:0046395 carboxylic acid catabolic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0080090 regulation of primary metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1903018 regulation of glycoprotein metabolic process; GO:1903019 negative regulation of glycoprotein metabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005782 peroxisomal matrix; GO:0005829 cytosol; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0003986 acetyl-CoA hydrolase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016289 CoA hydrolase activity; GO:0016290 palmitoyl-CoA hydrolase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016790 thiolester hydrolase activity; GO:0047617 acyl-CoA hydrolase activity; GO:0052815 medium-chain acyl-CoA hydrolase activity;",null,null,"I","KOG3016","Acyl-CoA thioesterase","WP5064 7OXOC AND 7BETAHC PATHWAYS;WP4545 OXYSTEROLS DERIVED FROM CHOLESTEROL","http://www.wikipathways.org/instance/WP5064_r120384;http://www.wikipathways.org/instance/WP4545_r120411",null,"R-HSA-1430728 Metabolism;R-HSA-192105 Synthesis of bile acids and bile salts;R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;R-HSA-194068 Bile acid and bile salt metabolism;R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism;R-HSA-2046106 alpha-linolenic acid (ALA) metabolism;R-HSA-389887 Beta-oxidation of pristanoyl-CoA;R-HSA-390247 Beta-oxidation of very long chain fatty acids;R-HSA-390918 Peroxisomal lipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8957322 Metabolism of steroids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-192105;https://reactome.org/PathwayBrowser/#/R-HSA-193368;https://reactome.org/PathwayBrowser/#/R-HSA-194068;https://reactome.org/PathwayBrowser/#/R-HSA-2046104;https://reactome.org/PathwayBrowser/#/R-HSA-2046106;https://reactome.org/PathwayBrowser/#/R-HSA-389887;https://reactome.org/PathwayBrowser/#/R-HSA-390247;https://reactome.org/PathwayBrowser/#/R-HSA-390918;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8957322;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","FATTY ACID METABOLISM;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Homo sapiens OX=9606 GN=CDIPT PE=1 SV=1","CDIPT",0.809729058,0.092365245,"nochange",19375,19242,20916,18566.3,16291.9,13347.4,1.07900047,1.071593654,1.164819294,1.033963686,0.907301561,0.743321335,"plasma membrane","K00999","CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa00564 Glycerophospholipid metabolism; hsa01100 Metabolic pathways","GO:0006139 nucleobase-containing compound metabolic process; GO:0006220 pyrimidine nucleotide metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007602 phototransduction; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0019637 organophosphate metabolic process; GO:0023052 signaling; GO:0030198 extracellular matrix organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0043062 extracellular structure organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0046341 CDP-diacylglycerol metabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071711 basement membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0072527 pyrimidine-containing compound metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; GO:0005488 binding; GO:0008289 lipid binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016780 phosphotransferase activity"," for other substituted phosphate groups; GO:0017169 CDP-alcohol phosphatidyltransferase activity; GO:0019992 diacylglycerol binding; GO:0030145 manganese ion binding; GO:0030246 carbohydrate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043178 alcohol binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding;",null,null,"I","KOG3240","Phosphatidylinositol synthase","WP4949 16P112 PROXIMAL DELETION SYNDROME;WP4722 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS;WP2533 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY","http://www.wikipathways.org/instance/WP4949_r115778;http://www.wikipathways.org/instance/WP4722_r117144;http://www.wikipathways.org/instance/WP2533_r120261",null,"R-HSA-1430728 Metabolism;R-HSA-1483206 Glycerophospholipid biosynthesis;R-HSA-1483226 Synthesis of PI;R-HSA-1483257 Phospholipid metabolism;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483206;https://reactome.org/PathwayBrowser/#/R-HSA-1483226;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["O14737","Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3","PDCD5",0.879235825,0.02052278,"nochange",55798.9,52893.6,52338.7,44542.5,48577.1,48464.8,1.106332258,1.048728486,1.037726409,0.883150109,0.963144663,0.960918076,"cytoplasm","K06875",null,null,"GO:0006915 apoptotic process; GO:0008219 cell death; GO:0008285 negative regulation of cell population proliferation; GO:0009719 response to endogenous stimulus; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0044093 positive regulation of molecular function; GO:0045862 positive regulation of proteolysis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090199 regulation of release of cytochrome c from mitochondria; GO:0090200 positive regulation of release of cytochrome c from mitochondria; GO:0090316 positive regulation of intracellular protein transport; GO:1903214 regulation of protein targeting to mitochondrion; GO:1903332 regulation of protein folding; GO:1903333 negative regulation of protein folding; GO:1903533 regulation of protein targeting; GO:1903636 regulation of protein insertion into mitochondrial outer membrane; GO:1903638 positive regulation of protein insertion into mitochondrial outer membrane; GO:1903644 regulation of chaperone-mediated protein folding; GO:1903645 negative regulation of chaperone-mediated protein folding; GO:1903747 regulation of establishment of protein localization to mitochondrion; GO:1903749 positive regulation of establishment of protein localization to mitochondrion; GO:1903829 positive regulation of protein localization; GO:1903955 positive regulation of protein targeting to mitochondrion; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0005539 glycosaminoglycan binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0008201 heparin binding; GO:0010698 acetyltransferase activator activity; GO:0015631 tubulin binding; GO:0030234 enzyme regulator activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0048487 beta-tubulin binding; GO:0097367 carbohydrate derivative binding; GO:0098772 molecular function regulator; GO:1901681 sulfur compound binding;",null,null,"D","KOG3431","Apoptosis-related protein/predicted DNA-binding protein"]
["O14744","Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4","PRMT5",0.815857413,1.700259E-3,"down",28131.5,27913.4,28047,23013.5,23860.1,21733.4,1.10537142,1.096801614,1.102051161,0.904269775,0.937535241,0.853970788,"cytoplasm","K02516",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0000578 embryonic axis specification; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006351 transcription"," DNA-templated; GO:0006353 DNA-templated transcription"," termination; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007028 cytoplasm organization; GO:0007030 Golgi organization; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007318 pole plasm protein localization; GO:0007346 regulation of mitotic cell cycle; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007623 circadian rhythm; GO:0007626 locomotory behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008219 cell death; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008283 cell population proliferation; GO:0008298 intracellular mRNA localization; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008380 RNA splicing; GO:0008595 anterior/posterior axis specification"," embryo; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0012501 programmed cell death; GO:0014013 regulation of gliogenesis; GO:0014015 positive regulation of gliogenesis; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018195 peptidyl-arginine modification; GO:0018216 peptidyl-arginine methylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019918 peptidyl-arginine methylation"," to symmetrical-dimethyl arginine; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0030719 P granule organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0032922 circadian regulation of gene expression; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034969 histone arginine methylation; GO:0035075 response to ecdysone; GO:0035076 ecdysone receptor-mediated signaling pathway; GO:0035246 peptidyl-arginine N-methylation; GO:0035247 peptidyl-arginine omega-N-methylation; GO:0035282 segmentation; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0036314 response to sterol; GO:0036315 cellular response to sterol; GO:0040007 growth; GO:0042118 endothelial cell activation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043408 regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043516 regulation of DNA damage response"," signal transduction by p53 class mediator; GO:0043518 negative regulation of DNA damage response"," signal transduction by p53 class mediator; GO:0043933 protein-containing complex organization; GO:0043985 histone H4-R3 methylation; GO:0044030 regulation of DNA methylation; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045685 regulation of glial cell differentiation; GO:0045687 positive regulation of glial cell differentiation; GO:0045745 positive regulation of G protein-coupled receptor signaling pathway; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048511 rhythmic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048699 generation of neurons; GO:0048713 regulation of oligodendrocyte differentiation; GO:0048714 positive regulation of oligodendrocyte differentiation; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060159 regulation of dopamine receptor signaling pathway; GO:0060161 positive regulation of dopamine receptor signaling pathway; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071390 cellular response to ecdysone; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090161 Golgi ribbon formation; GO:0090304 nucleic acid metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901797 negative regulation of signal transduction by p53 class mediator; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1904990 regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway; GO:1904992 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway; GO:1990834 response to odorant; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001020 regulation of response to DNA damage stimulus; GO:2001021 negative regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0034709 methylosome; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000166 nucleotide binding; GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0002039 p53 binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008327 methyl-CpG binding; GO:0008469 histone-arginine N-methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016273 arginine N-methyltransferase activity; GO:0016274 protein-arginine N-methyltransferase activity; GO:0016277 [myelin basic protein]-arginine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0035241 protein-arginine omega-N monomethyltransferase activity; GO:0035243 protein-arginine omega-N symmetric methyltransferase activity; GO:0036094 small molecule binding; GO:0042054 histone methyltransferase activity; GO:0042802 identical protein binding; GO:0043021 ribonucleoprotein complex binding; GO:0043565 sequence-specific DNA binding; GO:0044020 histone methyltransferase activity (H4-R3 specific); GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0070888 E-box binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF17285; PF05185; PF17286","PF17285 PRMT5 TIM barrel domain; PF05185 PRMT5 arginine-N-methyltransferase; PF17286 PRMT5 oligomerisation domain","D","KOG0822","Protein kinase inhibitor","WP3594 CIRCADIAN RHYTHM GENES;WP4947 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS;WP4533 TRANSCRIPTION COFACTORS SKI AND SKIL PROTEIN PARTNERS","http://www.wikipathways.org/instance/WP3594_r117682;http://www.wikipathways.org/instance/WP4947_r118070;http://www.wikipathways.org/instance/WP4533_r103380","Transcription factor","R-HSA-191859 snRNP Assembly;R-HSA-194441 Metabolism of non-coding RNA;R-HSA-212436 Generic Transcription Pathway;R-HSA-3214858 RMTs methylate histone arginines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-4839726 Chromatin organization;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-6804760 Regulation of TP53 Activity through Methylation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-191859;https://reactome.org/PathwayBrowser/#/R-HSA-194441;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3214858;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5633007;https://reactome.org/PathwayBrowser/#/R-HSA-6804760;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=SLC9A3R1 PE=1 SV=4","SLC9A3R1",0.958117473,0.175742557,"nochange",98273.5,94637.9,97245.4,96065,88571.5,93367.8,1.037806003,0.999412667,1.026948871,1.014483392,0.935349147,0.985999922,"nucleus","K13365","SLC9A3R1; sodium/hydrogen exchange regulatory cofactor NHE-RF1","hsa05165 Human papillomavirus infection; hsa05130 Pathogenic Escherichia coli infection; hsa04928 Parathyroid hormone synthesis"," secretion and action; hsa04530 Tight junction","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001738 morphogenesis of a polarized epithelium; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002028 regulation of sodium ion transport; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002093 auditory receptor cell morphogenesis; GO:0003008 system process; GO:0003014 renal system process; GO:0003096 renal sodium ion transport; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006814 sodium ion transport; GO:0006820 anion transport; GO:0006857 oligopeptide transport; GO:0006873 cellular ion homeostasis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007097 nuclear migration; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007187 G protein-coupled receptor signaling pathway"," coupled to cyclic nucleotide second messenger; GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway; GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway; GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway; GO:0007212 dopamine receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008104 protein localization; GO:0008285 negative regulation of cell population proliferation; GO:0008360 regulation of cell shape; GO:0008361 regulation of cell size; GO:0008544 epidermis development; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009913 epidermal cell differentiation; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010155 regulation of proton transport; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway; GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010766 negative regulation of sodium ion transport; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015833 peptide transport; GO:0015849 organic acid transport; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0019932 second-messenger-mediated signaling; GO:0019933 cAMP-mediated signaling; GO:0019935 cyclic-nucleotide-mediated signaling; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022612 gland morphogenesis; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030001 metal ion transport; GO:0030002 cellular anion homeostasis; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030033 microvillus assembly; GO:0030036 actin cytoskeleton organization; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030320 cellular monovalent inorganic anion homeostasis; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030643 cellular phosphate ion homeostasis; GO:0030855 epithelial cell differentiation; GO:0030859 polarized epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032409 regulation of transporter activity; GO:0032410 negative regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032413 negative regulation of ion transmembrane transporter activity; GO:0032415 regulation of sodium:proton antiporter activity; GO:0032416 negative regulation of sodium:proton antiporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032528 microvillus organization; GO:0032535 regulation of cellular component size; GO:0032782 bile acid secretion; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034635 glutathione transport; GO:0034762 regulation of transmembrane transport; GO:0034763 negative regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034766 negative regulation of ion transmembrane transport; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035089 establishment of apical/basal cell polarity; GO:0035315 hair cell differentiation; GO:0035556 intracellular signal transduction; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042471 ear morphogenesis; GO:0042472 inner ear morphogenesis; GO:0042490 mechanoreceptor differentiation; GO:0042491 inner ear auditory receptor cell differentiation; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0042939 tripeptide transport; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043269 regulation of ion transport; GO:0043271 negative regulation of ion transport; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043549 regulation of kinase activity; GO:0043583 ear development; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044062 regulation of excretion; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045198 establishment of epithelial cell apical/basal polarity; GO:0045786 negative regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045930 negative regulation of mitotic cell cycle; GO:0045936 negative regulation of phosphate metabolic process; GO:0046717 acid secretion; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0046942 carboxylic acid transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050954 sensory perception of mechanical stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051645 Golgi localization; GO:0051647 nucleus localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051683 establishment of Golgi localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051896 regulation of protein kinase B signaling; GO:0051898 negative regulation of protein kinase B signaling; GO:0055062 phosphate ion homeostasis; GO:0055081 anion homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055083 monovalent inorganic anion homeostasis; GO:0060088 auditory receptor cell stereocilium organization; GO:0060113 inner ear receptor cell differentiation; GO:0060117 auditory receptor cell development; GO:0060119 inner ear receptor cell development; GO:0060122 inner ear receptor cell stereocilium organization; GO:0060158 phospholipase C-activating dopamine receptor signaling pathway; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060563 neuroepithelial cell differentiation; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0061162 establishment of monopolar cell polarity; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061339 establishment or maintenance of monopolar cell polarity; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070293 renal absorption; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070373 negative regulation of ERK1 and ERK2 cascade; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072337 modified amino acid transport; GO:0072348 sulfur compound transport; GO:0072501 cellular divalent inorganic anion homeostasis; GO:0072502 cellular trivalent inorganic anion homeostasis; GO:0072505 divalent inorganic anion homeostasis; GO:0072506 trivalent inorganic anion homeostasis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090162 establishment of epithelial cell polarity; GO:0090596 sensory organ morphogenesis; GO:0097291 renal phosphate ion absorption; GO:0098771 inorganic ion homeostasis; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1902305 regulation of sodium ion transmembrane transport; GO:1902306 negative regulation of sodium ion transmembrane transport; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1904062 regulation of cation transmembrane transport; GO:1904063 negative regulation of cation transmembrane transport; GO:1990778 protein localization to cell periphery; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2000650 negative regulation of sodium ion transmembrane transporter activity; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005902 microvillus; GO:0005903 brush border; GO:0005929 cilium; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0030175 filopodium; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031514 motile cilium; GO:0031526 brush border membrane; GO:0031528 microvillus membrane; GO:0032420 stereocilium; GO:0032421 stereocilium bundle; GO:0032426 stereocilium tip; GO:0036126 sperm flagellum; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045121 membrane raft; GO:0045177 apical part of cell; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097225 sperm midpiece; GO:0097729 9+2 motile cilium; GO:0098590 plasma membrane region; GO:0098857 membrane microdomain; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0120025 plasma membrane bounded cell projection;","GO:0001664 G protein-coupled receptor binding; GO:0005102 signaling receptor binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008092 cytoskeletal protein binding; GO:0016247 channel regulator activity; GO:0017022 myosin binding; GO:0017081 chloride channel regulator activity; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019904 protein domain specific binding; GO:0030165 PDZ domain binding; GO:0031690 adrenergic receptor binding; GO:0031698 beta-2 adrenergic receptor binding; GO:0043621 protein self-association; GO:0044877 protein-containing complex binding; GO:0045159 myosin II binding; GO:0050780 dopamine receptor binding; GO:0070851 growth factor receptor binding; GO:0098772 molecular function regulator;","PF00595; PF09007","PF00595 PDZ domain; PF09007 EBP50"," C-terminal","S","KOG3528","FOG: PDZ domain",{"$nulls":5},"ESTROGEN RESPONSE EARLY;ESTROGEN RESPONSE LATE;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["O14757","Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2","CHEK1",0.522085556,{"v":3.31947e-05,"d":"3.32E-05"},"down",17206.8,18365,17249.6,9606.72,9094.72,8875.85,1.284110475,1.370544719,1.287304557,0.716931084,0.678721507,0.662387658,"cytoplasm","K02216","CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]","hsa04110 Cell cycle; hsa04115 p53 signaling pathway; hsa04218 Cellular senescence; hsa05170 Human immunodeficiency virus 1 infection; hsa05203 Viral carcinogenesis; hsa05166 Human T-cell leukemia virus 1 infection","GO:0000018 regulation of DNA recombination; GO:0000075 cell cycle checkpoint signaling; GO:0000076 DNA replication checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001701 in utero embryonic development; GO:0001824 blastocyst development; GO:0001832 blastocyst growth; GO:0001833 inner cell mass cell proliferation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006281 DNA repair; GO:0006282 regulation of DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006975 DNA damage induced protein phosphorylation; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007088 regulation of mitotic nuclear division; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007098 centrosome cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007348 regulation of syncytial blastoderm mitotic cell cycle; GO:0007349 cellularization; GO:0007444 imaginal disc development; GO:0007568 aging; GO:0007569 cell aging; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009410 response to xenobiotic stimulus; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009794 regulation of mitotic cell cycle"," embryonic; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010569 regulation of double-strand break repair via homologous recombination; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016570 histone modification; GO:0016572 histone phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018107 peptidyl-threonine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0018210 peptidyl-threonine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0031000 response to caffeine; GO:0031023 microtubule organizing center organization; GO:0031056 regulation of histone modification; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031570 DNA integrity checkpoint signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032886 regulation of microtubule-based process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033314 mitotic DNA replication checkpoint signaling; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034644 cellular response to UV; GO:0034645 cellular macromolecule biosynthetic process; GO:0035065 regulation of histone acetylation; GO:0035295 tube development; GO:0035405 histone-threonine phosphorylation; GO:0035407 histone H3-T11 phosphorylation; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0036270 response to diuretic; GO:0040007 growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042770 signal transduction in response to DNA damage; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043279 response to alkaloid; GO:0043412 macromolecule modification; GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044818 mitotic G2/M transition checkpoint; GO:0044839 cell cycle G2/M phase transition; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045839 negative regulation of mitotic nuclear division; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045995 regulation of embryonic development; GO:0046483 heterocycle metabolic process; GO:0046602 regulation of mitotic centrosome separation; GO:0046605 regulation of centrosome cycle; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048589 developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051225 spindle assembly; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051299 centrosome separation; GO:0051493 regulation of cytoskeleton organization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0070316 regulation of G0 to G1 transition; GO:0070317 negative regulation of G0 to G1 transition; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071214 cellular response to abiotic stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071312 cellular response to alkaloid; GO:0071313 cellular response to caffeine; GO:0071407 cellular response to organic cyclic compound; GO:0071415 cellular response to purine-containing compound; GO:0071417 cellular response to organonitrogen compound; GO:0071466 cellular response to xenobiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0090399 replicative senescence; GO:0104004 cellular response to environmental stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901983 regulation of protein acetylation; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902742 apoptotic process involved in development; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000279 negative regulation of DNA biosynthetic process; GO:2000615 regulation of histone H3-K9 acetylation; GO:2000756 regulation of peptidyl-lysine acetylation; GO:2000779 regulation of double-strand break repair; GO:2001020 regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019904 protein domain specific binding; GO:0035173 histone kinase activity; GO:0035184 histone threonine kinase activity; GO:0035402 histone kinase activity (H3-T11 specific); GO:0140096 catalytic activity"," acting on a protein;","PF00069","PF00069 Protein kinase domain","D","KOG0590","Checkpoint kinase and related serine/threonine protein kinases","WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE;WP2516 ATM SIGNALING PATHWAY;WP3875 ATR SIGNALING;WP179 CELL CYCLE;WP707 DNA DAMAGE RESPONSE;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR;WP3959 DNA IRDOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP1971 INTEGRATED CANCER PATHWAY;WP1530 MIRNA REGULATION OF DNA DAMAGE RESPONSE;WP3651 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA;WP2446 RETINOBLASTOMA GENE IN CANCER","http://www.wikipathways.org/instance/WP3878_r117656;http://www.wikipathways.org/instance/WP2516_r116808;http://www.wikipathways.org/instance/WP3875_r117657;http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP707_r116541;http://www.wikipathways.org/instance/WP4016_r120667;http://www.wikipathways.org/instance/WP3959_r118468;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP1971_r117762;http://www.wikipathways.org/instance/WP1530_r118120;http://www.wikipathways.org/instance/WP3651_r116547;http://www.wikipathways.org/instance/WP2446_r116593",null,"R-HSA-1433557 Signaling by SCF-KIT;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-176187 Activation of ATR in response to replication stress;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex;R-HSA-8953750 Transcriptional Regulation by E2F6;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases","https://reactome.org/PathwayBrowser/#/R-HSA-1433557;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-176187;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5633007;https://reactome.org/PathwayBrowser/#/R-HSA-5685942;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693538;https://reactome.org/PathwayBrowser/#/R-HSA-5693567;https://reactome.org/PathwayBrowser/#/R-HSA-5693579;https://reactome.org/PathwayBrowser/#/R-HSA-5693607;https://reactome.org/PathwayBrowser/#/R-HSA-5693616;https://reactome.org/PathwayBrowser/#/R-HSA-6796648;https://reactome.org/PathwayBrowser/#/R-HSA-6804756;https://reactome.org/PathwayBrowser/#/R-HSA-69473;https://reactome.org/PathwayBrowser/#/R-HSA-69481;https://reactome.org/PathwayBrowser/#/R-HSA-69601;https://reactome.org/PathwayBrowser/#/R-HSA-69610;https://reactome.org/PathwayBrowser/#/R-HSA-69613;https://reactome.org/PathwayBrowser/#/R-HSA-69615;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75035;https://reactome.org/PathwayBrowser/#/R-HSA-8953750;https://reactome.org/PathwayBrowser/#/R-HSA-9006934","E2F TARGETS;G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O14772","Fucose-1-phosphate guanylyltransferase OS=Homo sapiens OX=9606 GN=FPGT PE=1 SV=3","FPGT",1.032078485,0.674178707,"nochange",6379.69,5069.53,5031.92,5958.82,5479.98,5571.03,1.142939127,0.908220335,0.9014824,1.067539101,0.981753589,0.998065449,"cytoplasm","K00976","FPGT; fucose-1-phosphate guanylyltransferase [EC:2.7.7.30]","hsa01250 Biosynthesis of nucleotide sugars; hsa00051 Fructose and mannose metabolism; hsa00520 Amino sugar and nucleotide sugar metabolism; hsa01100 Metabolic pathways","GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006004 fucose metabolic process; GO:0008152 metabolic process; GO:0019318 hexose metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0071704 organic substance metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0047341 fucose-1-phosphate guanylyltransferase activity; GO:0070568 guanylyltransferase activity;",{"$nulls":8},"R-HSA-392499 Metabolism of proteins;R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide"," LLO) and transfer to a nascent protein;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-446219 Synthesis of substrates in N-glycan biosythesis;R-HSA-597592 Post-translational protein modification;R-HSA-6787639 GDP-fucose biosynthesis","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446193;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-446219;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6787639"]
["O14773","Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2","TPP1",0.969259941,0.56326725,"nochange",27241.8,24340.6,25362.8,24716.9,23301.1,26561.9,1.078704452,0.963824475,1.004300938,0.978724977,0.922662978,1.05178218,"extracellular","K01279","TPP1; tripeptidyl-peptidase I [EC:3.4.14.9]","hsa04142 Lysosome","GO:0001894 tissue homeostasis; GO:0003008 system process; GO:0006508 proteolysis; GO:0006518 peptide metabolic process; GO:0006629 lipid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0007033 vacuole organization; GO:0007040 lysosome organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030855 epithelial cell differentiation; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034620 cellular response to unfolded protein; GO:0034641 cellular nitrogen compound metabolic process; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036498 IRE1-mediated unfolded protein response; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043171 peptide catabolic process; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0045453 bone resorption; GO:0046849 bone remodeling; GO:0048731 system development; GO:0048771 tissue remodeling; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050885 neuromuscular process controlling balance; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051716 cellular response to stimulus; GO:0060249 anatomical structure homeostasis; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080171 lytic vacuole organization; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0031974 membrane-enclosed lumen; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0005488 binding; GO:0008233 peptidase activity; GO:0008236 serine-type peptidase activity; GO:0008238 exopeptidase activity; GO:0008240 tripeptidyl-peptidase activity; GO:0016787 hydrolase activity; GO:0017171 serine hydrolase activity; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0140096 catalytic activity"," acting on a protein;","PF09286; PF00082","PF09286 Pro-kumamolisin"," activation domain ; PF00082 Subtilase family",{"$nulls":3},"WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-2262752 Cellular responses to stress;R-HSA-381038 XBP1(S) activates chaperone genes;R-HSA-381070 IRE1alpha activates chaperones;R-HSA-381119 Unfolded Protein Response (UPR);R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-381038;https://reactome.org/PathwayBrowser/#/R-HSA-381070;https://reactome.org/PathwayBrowser/#/R-HSA-381119;https://reactome.org/PathwayBrowser/#/R-HSA-8953897"]
["O14776","Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2","TCERG1",1.797987584,{"v":7.52179e-05,"d":"7.52E-05"},"up",78682.8,86246.5,79483.4,145165,152058,142228,0.690337563,0.756699032,0.69736177,1.273630988,1.334107952,1.247862695,"nucleus","K12824","TCERG1; transcription elongation regulator 1","hsa03040 Spliceosome","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0042802 identical protein binding; GO:0070064 proline-rich region binding; GO:0140110 transcription regulator activity;","PF00397","PF00397 WW domain","K","KOG0155","Transcription factor CA150"]
["O14777","Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1","NDC80",0.66791509,0.005923501,"down",6361.34,5894.11,5999.58,3652.95,3882.89,4656.97,1.253554932,1.161483376,1.182267116,0.719844166,0.765155755,0.917694654,"mitochondria","K11547",null,null,"GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000132 establishment of mitotic spindle orientation; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0003006 developmental process involved in reproduction; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0007079 mitotic chromosome movement towards spindle pole; GO:0007080 mitotic metaphase plate congression; GO:0007088 regulation of mitotic nuclear division; GO:0007163 establishment or maintenance of cell polarity; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007548 sex differentiation; GO:0008104 protein localization; GO:0008406 gonad development; GO:0008608 attachment of spindle microtubules to kinetochore; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0010638 positive regulation of organelle organization; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030010 establishment of cell polarity; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030334 regulation of cell migration; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033365 protein localization to organelle; GO:0034501 protein localization to kinetochore; GO:0034502 protein localization to chromosome; GO:0034508 centromere complex assembly; GO:0034613 cellular protein localization; GO:0035262 gonad morphogenesis; GO:0040001 establishment of mitotic spindle localization; GO:0040012 regulation of locomotion; GO:0043254 regulation of protein-containing complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045137 development of primary sexual characteristics; GO:0045787 positive regulation of cell cycle; GO:0045840 positive regulation of mitotic nuclear division; GO:0045931 positive regulation of mitotic cell cycle; GO:0048285 organelle fission; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048608 reproductive structure development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050000 chromosome localization; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051270 regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051303 establishment of chromosome localization; GO:0051305 chromosome movement towards spindle pole; GO:0051310 metaphase plate congression; GO:0051315 attachment of mitotic spindle microtubules to kinetochore; GO:0051382 kinetochore assembly; GO:0051383 kinetochore organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051984 positive regulation of chromosome segregation; GO:0060341 regulation of cellular localization; GO:0061458 reproductive system development; GO:0062033 positive regulation of mitotic sister chromatid segregation; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071459 protein localization to chromosome"," centromeric region; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090068 positive regulation of cell cycle process; GO:0090230 regulation of centromere complex assembly; GO:0090231 regulation of spindle checkpoint; GO:0090232 positive regulation of spindle checkpoint; GO:0090234 regulation of kinetochore assembly; GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint; GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1901970 positive regulation of mitotic sister chromatid separation; GO:1901976 regulation of cell cycle checkpoint; GO:1901978 positive regulation of cell cycle checkpoint; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1903394 protein localization to kinetochore involved in kinetochore assembly; GO:1903504 regulation of mitotic spindle checkpoint; GO:1903829 positive regulation of protein localization; GO:1905340 regulation of protein localization to kinetochore; GO:1905342 positive regulation of protein localization to kinetochore; GO:1905561 positive regulation of kinetochore assembly; GO:1905818 regulation of chromosome separation; GO:1905820 positive regulation of chromosome separation; GO:2000145 regulation of cell motility; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000940 outer kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031262 Ndc80 complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0019904 protein domain specific binding; GO:0042802 identical protein binding;","PF18077","PF18077 Domain of unknown function (DUF5595)","D","KOG0995","Centromere-associated protein HEC1",{"$nulls":3},"R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","G2M CHECKPOINT;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O14786","Neuropilin-1 OS=Homo sapiens OX=9606 GN=NRP1 PE=1 SV=3","NRP1",0.560300443,0.002541637,"down",3934.15,3933.56,3104.1,1935.92,2045.81,2165.78,1.378845655,1.378638871,1.087928726,0.678503585,0.717017966,0.759065197,"endoplasmic reticulum","K06724","NRP1; neuropilin 1","hsa04360 Axon guidance; hsa05166 Human T-cell leukemia virus 1 infection; hsa05171 Coronavirus disease - COVID-19","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001501 skeletal system development; GO:0001525 angiogenesis; GO:0001558 regulation of cell growth; GO:0001568 blood vessel development; GO:0001569 branching involved in blood vessel morphogenesis; GO:0001570 vasculogenesis; GO:0001654 eye development; GO:0001655 urogenital system development; GO:0001666 response to hypoxia; GO:0001667 ameboidal-type cell migration; GO:0001708 cell fate specification; GO:0001755 neural crest cell migration; GO:0001763 morphogenesis of a branching structure; GO:0001764 neuron migration; GO:0001822 kidney development; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001936 regulation of endothelial cell proliferation; GO:0001938 positive regulation of endothelial cell proliferation; GO:0001944 vasculature development; GO:0001952 regulation of cell-matrix adhesion; GO:0001954 positive regulation of cell-matrix adhesion; GO:0002009 morphogenesis of an epithelium; GO:0002040 sprouting angiogenesis; GO:0002042 cell migration involved in sprouting angiogenesis; GO:0002164 larval development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003002 regionalization; GO:0003007 heart morphogenesis; GO:0003148 outflow tract septum morphogenesis; GO:0003151 outflow tract morphogenesis; GO:0003158 endothelium development; GO:0003205 cardiac chamber development; GO:0003206 cardiac chamber morphogenesis; GO:0003279 cardiac septum development; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006929 substrate-dependent cell migration; GO:0006930 substrate-dependent cell migration",{"$cut":{"chars":24843,"head":" cell extension; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007350 blastoderm segmentation; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007413 axonal fasciculation; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007507 heart development; GO:0007508 larval heart development; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008045 motor neuron axon guidance; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008361 regulation of cell size; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010469 regulation of signaling receptor activity; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010631 epithelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0014031 mesenchymal cell development; GO:0014032 neural crest cell development; GO:0014033 neural crest cell differentiation; GO:0014910 regulation of smooth muscle cell migration; GO:0014911 positive regulation of smooth muscle cell migration; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016310 phosphorylation; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0021535 cell migration in hindbrain; GO:0021536 diencephalon development; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021545 cranial nerve development;"}},"GO:0002116 semaphorin receptor complex; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005882 intermediate filament; GO:0005883 neurofilament; GO:0005886 plasma membrane; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032584 growth cone membrane; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043235 receptor complex; GO:0043679 axon terminus; GO:0044295 axonal growth cone; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0045111 intermediate filament cytoskeleton; GO:0045202 synapse; GO:0070161 anchoring junction; GO:0070852 cell body fiber; GO:0071944 cell periphery; GO:0097443 sorting endosome; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004714 transmembrane receptor protein tyrosine kinase activity; GO:0004888 transmembrane signaling receptor activity; GO:0005021 vascular endothelial growth factor-activated receptor activity; GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0015026 coreceptor activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017154 semaphorin receptor activity; GO:0019199 transmembrane receptor protein kinase activity; GO:0019838 growth factor binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019955 cytokine binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0038023 signaling receptor activity; GO:0038085 vascular endothelial growth factor binding; GO:0060089 molecular transducer activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF00431; PF00754; PF00629","PF00431 CUB domain; PF00754 F5/8 type C domain; PF00629 MAM domain"," meprin/A5/mu",{"$nulls":3},"WP5144 NRP1TRIGGERED SIGNALING PATHWAYS IN PANCREATIC CANCER;WP5065 SARSCOV2 ALTERING ANGIOGENESIS VIA NRP1;WP4846 SARSCOV2 AND COVID19 PATHWAY","http://www.wikipathways.org/instance/WP5144_r120537;http://www.wikipathways.org/instance/WP5065_r118890;http://www.wikipathways.org/instance/WP4846_r120585",null,"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-194138 Signaling by VEGF;R-HSA-194306 Neurophilin interactions with VEGF and VEGFR;R-HSA-373755 Semaphorin interactions;R-HSA-373760 L1CAM interactions;R-HSA-376176 Signaling by ROBO receptors;R-HSA-399954 Sema3A PAK dependent Axon repulsion;R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;R-HSA-399956 CRMPs in Sema3A signaling;R-HSA-422475 Axon guidance;R-HSA-445144 Signal transduction by L1;R-HSA-447041 CHL1 interactions;R-HSA-5663205 Infectious disease;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9675108 Nervous system development;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694614 Attachment and Entry;R-HSA-9772572 Early SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-194306;https://reactome.org/PathwayBrowser/#/R-HSA-373755;https://reactome.org/PathwayBrowser/#/R-HSA-373760;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-399954;https://reactome.org/PathwayBrowser/#/R-HSA-399955;https://reactome.org/PathwayBrowser/#/R-HSA-399956;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-445144;https://reactome.org/PathwayBrowser/#/R-HSA-447041;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694614;https://reactome.org/PathwayBrowser/#/R-HSA-9772572","ANGIOGENESIS;HEDGEHOG SIGNALING;IL2 STAT5 SIGNALING;KRAS SIGNALING UP;UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANGIOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEDGEHOG_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["O14787","Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3","TNPO2",1.113791316,0.230457355,"nochange",142178,135589,123529,141353,137701,167906,1.005672816,0.959066603,0.873762166,0.999837313,0.974005489,1.187655613,"cytoplasm","K18727","TNPO2; transportin-2","hsa03013 Nucleocytoplasmic transport","GO:0002164 larval development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006610 ribosomal protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0009791 post-embryonic development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0017038 protein import; GO:0030097 hemopoiesis; GO:0032386 regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035166 post-embryonic hemopoiesis; GO:0035167 larval lymph gland hemopoiesis; GO:0042306 regulation of protein import into nucleus; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048542 lymph gland development; GO:0048569 post-embryonic animal organ development; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0090087 regulation of peptide transport; GO:1900180 regulation of protein localization to nucleus; GO:1904589 regulation of protein import;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005048 signal sequence binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0008139 nuclear localization sequence binding; GO:0033218 amide binding; GO:0042277 peptide binding;",null,null,"YU","KOG2023","Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)",{"$nulls":5},"G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O14802","DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2","POLR3A",0.746073977,2.41857E-4,"down",23413.4,24437.8,24276.5,17245,18277.2,18290.4,1.115452321,1.164256398,1.156571804,0.821579748,0.870755429,0.871384299,"cytoplasm","K03018","RPC1; DNA-directed RNA polymerase III subunit RPC1 [EC:2.7.7.6]","hsa04623 Cytosolic DNA-sensing pathway; hsa03020 RNA polymerase","GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002376 immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032648 regulation of interferon-beta production; GO:0032728 positive regulation of interferon-beta production; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045087 innate immune response; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005666 RNA polymerase III complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0003899 DNA-directed 5'-3' RNA polymerase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0034062 5'-3' RNA polymerase activity; GO:0097747 RNA polymerase activity; GO:0140098 catalytic activity"," acting on RNA;","PF04997; PF00623; PF04983; PF05000; PF04998","PF04997 RNA polymerase Rpb1"," domain 1; PF00623 RNA polymerase Rpb1"," domain 2; PF04983 RNA polymerase Rpb1"," domain 3; PF05000 RNA polymerase Rpb1"," domain 4; PF04998 RNA polymerase Rpb1"," domain 5","K","KOG0261","RNA polymerase III"," large subunit","WP4655 CYTOSOLIC DNASENSING PATHWAY;WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP4655_r105163;http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-73780 RNA Polymerase III Chain Elongation;R-HSA-73980 RNA Polymerase III Transcription Termination;R-HSA-74158 RNA Polymerase III Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation;R-HSA-76046 RNA Polymerase III Transcription Initiation;R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter;R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter;R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1834949;https://reactome.org/PathwayBrowser/#/R-HSA-73780;https://reactome.org/PathwayBrowser/#/R-HSA-73980;https://reactome.org/PathwayBrowser/#/R-HSA-74158;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-749476;https://reactome.org/PathwayBrowser/#/R-HSA-76046;https://reactome.org/PathwayBrowser/#/R-HSA-76061;https://reactome.org/PathwayBrowser/#/R-HSA-76066;https://reactome.org/PathwayBrowser/#/R-HSA-76071"]
["O14818","Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1","PSMA7",1.152845029,0.009119273,"up",208215,205403,195005,228347,228797,244504,0.953459246,0.940582521,0.892967943,1.045647809,1.047708451,1.11963403,"cytoplasm","K02731","PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]","hsa05017 Spinocerebellar ataxia; hsa05016 Huntington disease; hsa03050 Proteasome; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease","GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0016579 protein deubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0036211 protein modification process; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000502 proteasome complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005839 proteasome core complex; GO:0019773 proteasome core complex"," alpha-subunit complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0098794 postsynapse; GO:1902494 catalytic complex; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex; GO:1990111 spermatoproteasome complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;","PF00227","PF00227 Proteasome subunit","O","KOG0183","20S proteasome"," regulatory subunit alpha type PSMA7/PRE6","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O14828","Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3","SCAMP3",0.635689705,1.953073E-3,"down",29981.2,35858.6,32524.7,19463,21913.8,21152.5,1.118049297,1.337227413,1.212900684,0.725807955,0.817202403,0.788812248,"plasma membrane","K19995",null,null,"GO:0001101 response to acid chemical; GO:0001505 regulation of neurotransmitter levels; GO:0003008 system process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007274 neuromuscular synaptic transmission; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0023052 signaling; GO:0023061 signal release; GO:0032501 multicellular organismal process; GO:0032526 response to retinoic acid; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048489 synaptic vesicle transport; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:1901700 response to oxygen-containing compound;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding;",null,null,"U","KOG3088","Secretory carrier membrane protein",{"$nulls":5},"PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O14832","Phytanoyl-CoA dioxygenase"," peroxisomal OS=Homo sapiens OX=9606 GN=PHYH PE=1 SV=1","PHYH",0.981239304,0.962510639,"nochange",840.403,452.21,642.603,609.826,656.114,"NA",1.312655491,0.706322966,1.003704599,0.952509031,1.024807913,"NA","mitochondria","K00477","PHYH; phytanoyl-CoA hydroxylase [EC:1.14.11.18]","hsa04146 Peroxisome","GO:0001561 fatty acid alpha-oxidation; GO:0006082 organic acid metabolic process; GO:0006103 2-oxoglutarate metabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006720 isoprenoid metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0019395 fatty acid oxidation; GO:0019752 carboxylic acid metabolic process; GO:0030258 lipid modification; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034440 lipid oxidation; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0043648 dicarboxylic acid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045184 establishment of protein localization; GO:0046395 carboxylic acid catabolic process; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0097089 methyl-branched fatty acid metabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005782 peroxisomal matrix; GO:0005829 cytosol; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005506 iron ion binding; GO:0008198 ferrous iron binding; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0031406 carboxylic acid binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043177 organic acid binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0048244 phytanoyl-CoA dioxygenase activity; GO:0051213 dioxygenase activity;","PF05721","PF05721 Phytanoyl-CoA dioxygenase (PhyH)","I","KOG3290","Peroxisomal phytanoyl-CoA hydroxylase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-389599 Alpha-oxidation of phytanate;R-HSA-390918 Peroxisomal lipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9033241 Peroxisomal protein import;R-HSA-9033500 TYSND1 cleaves peroxisomal proteins;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-389599;https://reactome.org/PathwayBrowser/#/R-HSA-390918;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9033500;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","ADIPOGENESIS;BILE ACID METABOLISM;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O14841","5-oxoprolinase OS=Homo sapiens OX=9606 GN=OPLAH PE=1 SV=3","OPLAH",0.963588649,0.597726608,"nochange",7458.02,6500.41,6248.73,6124.05,6759.95,6587.39,1.12776601,0.982960819,0.944902977,0.926049465,1.022207213,0.996113517,"cytoplasm","K01469","OPLAH; 5-oxoprolinase (ATP-hydrolysing) [EC:3.5.2.9]","hsa00480 Glutathione metabolism; hsa01100 Metabolic pathways","GO:0006518 peptide metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006749 glutathione metabolic process; GO:0006750 glutathione biosynthetic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0019184 nonribosomal peptide biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042398 cellular modified amino acid biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016812 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in cyclic amides; GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity;","PF19278","PF19278 Hydantoinase/oxoprolinase C-terminal domain","E","KOG1939","Oxoprolinase","WP4518 GAMMAGLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE INCLUDING DISEASES;WP100 GLUTATHIONE METABOLISM","http://www.wikipathways.org/instance/WP4518_r119313;http://www.wikipathways.org/instance/WP100_r107114",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-1643685 Disease;R-HSA-174403 Glutathione synthesis and recycling;R-HSA-211859 Biological oxidations;R-HSA-5578998 Defective OPLAH causes OPLAHD;R-HSA-5579029 Metabolic disorders of biological oxidation enzymes;R-HSA-5668914 Diseases of metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-174403;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-5578998;https://reactome.org/PathwayBrowser/#/R-HSA-5579029;https://reactome.org/PathwayBrowser/#/R-HSA-5668914"]
["O14867","Transcription regulator protein BACH1 OS=Homo sapiens OX=9606 GN=BACH1 PE=1 SV=2","BACH1",1.13164602,0.000331345,"up",6662.69,6641.87,6493.38,7569.61,7388.91,7445.74,0.947252513,0.944292478,0.923181256,1.076191763,1.050501159,1.058580832,"nucleus","K09042",null,null,"GO:0000082 G1/S transition of mitotic cell cycle; GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000278 mitotic cell cycle; GO:0001666 response to hypoxia; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007049 cell cycle; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022402 cell cycle process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044839 cell cycle G2/M phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0070887 cellular response to chemical stimulus; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031463 Cul3-RING ubiquitin ligase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0020037 heme binding; GO:0043565 sequence-specific DNA binding; GO:0046906 tetrapyrrole binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00651","PF00651 BTB/POZ domain","K","KOG3863","bZIP transcription factor NRF1","WP4313 FERROPTOSIS;WP1971 INTEGRATED CANCER PATHWAY","http://www.wikipathways.org/instance/WP4313_r120500;http://www.wikipathways.org/instance/WP1971_r117762","Transcription factor","R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9707587 Regulation of HMOX1 expression and activity;R-HSA-9707616 Heme signaling;R-HSA-9708530 Regulation of BACH1 activity;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9707587;https://reactome.org/PathwayBrowser/#/R-HSA-9707616;https://reactome.org/PathwayBrowser/#/R-HSA-9708530;https://reactome.org/PathwayBrowser/#/R-HSA-9711123;https://reactome.org/PathwayBrowser/#/R-HSA-9755511;https://reactome.org/PathwayBrowser/#/R-HSA-9759194","HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase"," mitochondrial OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2","BCKDK",0.68451318,0.010382781,"nochange",11838.2,12898.2,11796.6,9453.61,8364.65,7189.06,1.154189643,1.257536522,1.150133766,0.92169914,0.815528746,0.700912182,"mitochondria","K00905",null,null,"GO:0006082 organic acid metabolic process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006520 cellular amino acid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009063 cellular amino acid catabolic process; GO:0009081 branched-chain amino acid metabolic process; GO:0009083 branched-chain amino acid catabolic process; GO:0009987 cellular process; GO:0016054 organic acid catabolic process; GO:0016310 phosphorylation; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex; GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045239 tricarboxylic acid cycle enzyme complex; GO:0045240 dihydrolipoyl dehydrogenase complex; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF02518","PF02518 Histidine kinase-"," DNA gyrase B-"," and HSP90-like ATPase","T","KOG0787","Dehydrogenase kinase","WP4297 THIAMINE METABOLIC PATHWAYS","http://www.wikipathways.org/instance/WP4297_r120409",null,"R-HSA-1430728 Metabolism;R-HSA-70895 Branched-chain amino acid catabolism;R-HSA-71291 Metabolism of amino acids and derivatives","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70895;https://reactome.org/PathwayBrowser/#/R-HSA-71291"]
["O14879","Interferon-induced protein with tetratricopeptide repeats 3 OS=Homo sapiens OX=9606 GN=IFIT3 PE=1 SV=1","IFIT3",1.646641933,0.004728586,"up",3350.3,2660.08,3178.09,5284.33,4517.1,5328.69,0.8266022,0.656307788,0.784113717,1.303775424,1.114480733,1.314720138,"cytoplasm","K24849",null,null,"GO:0002252 immune effector process; GO:0002376 immune system process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008285 negative regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0019221 cytokine-mediated signaling pathway; GO:0023052 signaling; GO:0034097 response to cytokine; GO:0034340 response to type I interferon; GO:0035456 response to interferon-beta; GO:0035458 cellular response to interferon-beta; GO:0035634 response to stilbenoid; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043207 response to external biotic stimulus; GO:0045087 innate immune response; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051607 defense response to virus; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060337 type I interferon signaling pathway; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071357 cellular response to type I interferon; GO:0098542 defense response to other organism;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;",null,null,"R","KOG1124","FOG: TPR repeat","WP4197 IMMUNE RESPONSE TO TUBERCULOSIS","http://www.wikipathways.org/instance/WP4197_r120647",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-168256 Immune System;R-HSA-909733 Interferon alpha/beta signaling;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-909733;https://reactome.org/PathwayBrowser/#/R-HSA-913531","INTERFERON ALPHA RESPONSE;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["O14880","Microsomal glutathione S-transferase 3 OS=Homo sapiens OX=9606 GN=MGST3 PE=1 SV=1","MGST3",0.912389358,0.10047668,"nochange",18012.8,17434.3,16059.2,15182.2,15330,16481.6,1.097225282,1.061986739,0.978224388,0.924803122,0.933806159,1.003954311,"extracellular","K00799","GST; glutathione S-transferase [EC:2.5.1.18]","hsa05204 Chemical carcinogenesis - DNA adducts; hsa00480 Glutathione metabolism; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa00982 Drug metabolism - cytochrome P450; hsa05200 Pathways in cancer; hsa05207 Chemical carcinogenesis - receptor activation; hsa05418 Fluid shear stress and atherosclerosis; hsa05225 Hepatocellular carcinoma; hsa00983 Drug metabolism - other enzymes; hsa01524 Platinum drug resistance; hsa00980 Metabolism of xenobiotics by cytochrome P450; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006690 icosanoid metabolic process; GO:0006691 leukotriene metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0016053 organic acid biosynthetic process; GO:0019370 leukotriene biosynthetic process; GO:0019752 carboxylic acid metabolic process; GO:0042221 response to chemical; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046456 icosanoid biosynthetic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0070887 cellular response to chemical stimulus; GO:0071466 cellular response to xenobiotic stimulus; GO:0071704 organic substance metabolic process; GO:0097237 cellular response to toxic substance; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901685 glutathione derivative metabolic process; GO:1901687 glutathione derivative biosynthetic process; GO:1990748 cellular detoxification;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0004364 glutathione transferase activity; GO:0004464 leukotriene-C4 synthase activity; GO:0004601 peroxidase activity; GO:0004602 glutathione peroxidase activity; GO:0016209 antioxidant activity; GO:0016491 oxidoreductase activity; GO:0016684 oxidoreductase activity"," acting on peroxide as acceptor; GO:0016740 transferase activity; GO:0016765 transferase activity"," transferring alkyl or aryl (other than methyl) groups; GO:0016829 lyase activity; GO:0016846 carbon-sulfur lyase activity;",{"$nulls":5},"WP702 METAPATHWAY BIOTRANSFORMATION PHASE I AND II;WP2884 NRF2 PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY","http://www.wikipathways.org/instance/WP702_r106643;http://www.wikipathways.org/instance/WP2884_r106658;http://www.wikipathways.org/instance/WP2882_r117808",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-211859 Biological oxidations;R-HSA-5423646 Aflatoxin activation and detoxification","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-5423646","ADIPOGENESIS;HEME METABOLISM;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O14893","Gem-associated protein 2 OS=Homo sapiens OX=9606 GN=GEMIN2 PE=1 SV=1","GEMIN2",0.798949287,0.150591182,"nochange",4600.85,3840,3366.37,3515.36,3287.68,2630.33,1.29963904,1.084715632,0.950925563,0.993011964,0.928697367,0.743010434,"nucleus","K13130",null,null,"GO:0000245 spliceosomal complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006913 nucleocytoplasmic transport; GO:0007275 multicellular organism development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0007629 flight behavior; GO:0008152 metabolic process; GO:0008344 adult locomotory behavior; GO:0008380 RNA splicing; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030534 adult behavior; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048856 anatomical structure development; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032797 SMN complex; GO:0032991 protein-containing complex; GO:0034718 SMN-Gemin2 complex; GO:0034719 SMN-Sm protein complex; GO:0034730 SmD-containing SMN-Sm protein complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071254 cytoplasmic U snRNP body; GO:0097504 Gemini of coiled bodies; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding;",{"$nulls":8},"R-HSA-1643685 Disease;R-HSA-191859 snRNP Assembly;R-HSA-194441 Metabolism of non-coding RNA;R-HSA-5663205 Infectious disease;R-HSA-8953854 Metabolism of RNA;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-9754678 SARS-CoV-2 modulates host translation machinery","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-191859;https://reactome.org/PathwayBrowser/#/R-HSA-194441;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9705683;https://reactome.org/PathwayBrowser/#/R-HSA-9754678"]
["O14907","Tax1-binding protein 3 OS=Homo sapiens OX=9606 GN=TAX1BP3 PE=1 SV=2","TAX1BP3",1.559216533,0.03261896,"nochange",2456.88,2461.88,1608.64,3552.35,3392.71,3232.57,0.882445587,0.884241453,0.577780465,1.275909112,1.218570694,1.161052689,"cytoplasm","K24067",null,null,"GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007266 Rho protein signal transduction; GO:0008285 negative regulation of cell population proliferation; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030178 negative regulation of Wnt signaling pathway; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0035556 intracellular signal transduction; GO:0042127 regulation of cell population proliferation; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0090630 activation of GTPase activity; GO:1903828 negative regulation of protein localization; GO:2000008 regulation of protein localization to cell surface; GO:2000009 negative regulation of protein localization to cell surface;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008022 protein C-terminus binding;","PF00595","PF00595 PDZ domain","M","KOG3553","Tax interaction protein TIP1",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-5666185;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O14908","PDZ domain-containing protein GIPC1 OS=Homo sapiens OX=9606 GN=GIPC1 PE=1 SV=2","GIPC1",0.765001517,0.000199739,"down",12976.9,13313.3,12943.5,9907.31,9741.93,10364.6,1.124392289,1.153539895,1.121498323,0.858425585,0.844096122,0.898047786,"nucleus","K20056",null,null,"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001667 ameboidal-type cell migration; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0002009 morphogenesis of an epithelium; GO:0006605 protein targeting; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006835 dicarboxylic acid transport; GO:0006865 amino acid transport; GO:0006886 intracellular protein transport; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0007154 cell communication; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0008045 motor neuron axon guidance; GO:0008104 protein localization; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0014047 glutamate secretion; GO:0015031 protein transport; GO:0015711 organic anion transport; GO:0015800 acidic amino acid transport; GO:0015833 peptide transport; GO:0015849 organic acid transport; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030182 neuron differentiation; GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031647 regulation of protein stability; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032465 regulation of cytokinesis; GO:0032467 positive regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0040011 locomotion; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043542 endothelial cell migration; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0045184 establishment of protein localization; GO:0045787 positive regulation of cell cycle; GO:0045861 negative regulation of proteolysis; GO:0046717 acid secretion; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0046942 carboxylic acid transport; GO:0048167 regulation of synaptic plasticity; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051302 regulation of cell division; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0097485 neuron projection guidance; GO:0098916 anterograde trans-synaptic signaling; GO:0099177 regulation of trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005903 brush border; GO:0005938 cell cortex; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030139 endocytic vesicle; GO:0030425 dendrite; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043197 dendritic spine; GO:0043198 dendritic shaft; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0044309 neuron spine; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0098862 cluster of actin-based cell projections; GO:0099503 secretory vesicle; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0001965 G-protein alpha-subunit binding; GO:0003779 actin binding; GO:0005096 GTPase activator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0017022 myosin binding; GO:0019904 protein domain specific binding; GO:0030165 PDZ domain binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00595","PF00595 PDZ domain","TU","KOG3938","RGS-GAIP interacting protein GIPC"," contains PDZ domain","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782"]
["O14920","Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Homo sapiens OX=9606 GN=IKBKB PE=1 SV=1","IKBKB",1.022620198,0.640016134,"nochange",9165.2,8343.79,9857.26,9377.37,9410.43,9197.48,0.993490153,0.90445088,1.068508133,1.016488975,1.020072616,0.996989243,"cytoplasm","K07209","IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]","hsa05120 Epithelial cell signaling in Helicobacter pylori infection; hsa05160 Hepatitis C; hsa04014 Ras signaling pathway; hsa04622 RIG-I-like receptor signaling pathway; hsa05166 Human T-cell leukemia virus 1 infection; hsa05200 Pathways in cancer; hsa01523 Antifolate resistance; hsa04621 NOD-like receptor signaling pathway; hsa04210 Apoptosis; hsa05206 MicroRNAs in cancer; hsa04660 T cell receptor signaling pathway; hsa04931 Insulin resistance; hsa05215 Prostate cancer; hsa04936 Alcoholic liver disease; hsa04932 Non-alcoholic fatty liver disease; hsa04662 B cell receptor signaling pathway; hsa05162 Measles; hsa04668 TNF signaling pathway; hsa05222 Small cell lung cancer; hsa04659 Th17 cell differentiation; hsa04722 Neurotrophin signaling pathway; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04920 Adipocytokine signaling pathway; hsa04930 Type II diabetes mellitus; hsa04068 FoxO signaling pathway; hsa04910 Insulin signaling pathway; hsa05417 Lipid and atherosclerosis; hsa04380 Osteoclast differentiation; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05170 Human immunodeficiency virus 1 infection; hsa05161 Hepatitis B; hsa05221 Acute myeloid leukemia; hsa05169 Epstein-Barr virus infection; hsa05010 Alzheimer disease; hsa05131 Shigellosis; hsa05418 Fluid shear stress and atherosclerosis; hsa05132 Salmonella infection; hsa05165 Human papillomavirus infection; hsa05168 Herpes simplex virus 1 infection; hsa05145 Toxoplasmosis; hsa04623 Cytosolic DNA-sensing pathway; hsa04625 C-type lectin receptor signaling pathway; hsa04010 MAPK signaling pathway; hsa05171 Coronavirus disease - COVID-19; hsa05135 Yersinia infection; hsa04062 Chemokine signaling pathway; hsa04150 mTOR signaling pathway; hsa04658 Th1 and Th2 cell differentiation; hsa05142 Chagas disease; hsa05164 Influenza A; hsa05212 Pancreatic cancer; hsa05163 Human cytomegalovirus infection; hsa05220 Chronic myeloid leukemia; hsa04620 Toll-like receptor signaling pathway; hsa05130 Pathogenic Escherichia coli infection; hsa04657 IL-17 signaling pathway; hsa04064 NF-kappa B signaling pathway; hsa04151 PI3K-Akt signaling pathway; hsa05167 Kaposi sarcoma-associated herpesvirus infection","GO:0000165 MAPK cascade; GO:0000302 response to reactive oxygen species; GO:0001101 response to acid chemical; GO:0001666 response to hypoxia; GO:0001776 leukocyte homeostasis; GO:0001782 B cell homeostasis; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0002028 regulation of sodium ion transport; GO:0002218 activation of innate immune response; GO:0002220 innate immune response activating cell surface receptor signaling pathway; GO:0002221 pattern recognition receptor signaling pathway; GO:0002223 stimulatory C-type lectin receptor signaling pathway; GO:0002224 toll-like receptor signaling pathway; GO:0002225 positive regulation of antimicrobial peptide production; GO:0002230 positive regulation of defense response to virus by host; GO:0002237 response to molecule of bacterial origin; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002260 lymphocyte homeostasis; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002474 antigen processing and presentation of peptide antigen via MHC class I; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I"," TAP-dependent; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002702 positive regulation of production of molecular mediator of immune response; GO:0002756 MyD88-independent toll-like receptor signaling pathway; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002759 regulation of antimicrobial humoral response; GO:0002760 positive regulation of antimicrobial humoral response; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0002784 regulation of antimicrobial peptide production; GO:0002786 regulation of antibacterial peptide production; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0002803 positive regulation of antibacterial peptide production; GO:0002805 regulation of antimicrobial peptide biosynthetic process; GO:0002807 positive regulation of antimicrobial peptide biosynthetic process; GO:0002808 regulation of antibacterial peptide biosynthetic process; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0002920 regulation of humoral immune response; GO:0002922 positive regulation of humoral immune response; GO:0003008 system process; GO:0003009 skeletal muscle contraction; GO:0003012 muscle system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006936 muscle contraction; GO:0006941 striated muscle contraction; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0006963 positive regulation of antibacterial peptide biosynthetic process; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007249 I-kappaB kinase/NF-kappaB signaling; GO:0007252 I-kappaB phosphorylation; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008063 Toll signaling pathway; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010765 positive regulation of sodium ion transport; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019730 antimicrobial humoral response; GO:0019731 antibacterial humoral response; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0022008 neurogenesis; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030856 regulation of epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032515 negative regulation of phosphoprotein phosphatase activity; GO:0032647 regulation of interferon-alpha production; GO:0032727 positive regulation of interferon-alpha production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033209 tumor necrosis factor-mediated signaling pathway; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034599 cellular response to oxidative stress; GO:0034612 response to tumor necrosis factor; GO:0034613 cellular protein localization; GO:0034614 cellular response to reactive oxygen species; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035308 negative regulation of protein dephosphorylation; GO:0035507 regulation of myosin-light-chain-phosphatase activity; GO:0035509 negative regulation of myosin-light-chain-phosphatase activity; GO:0035556 intracellular signal transduction; GO:0035666 TRIF-dependent toll-like receptor signaling pathway; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0038061 NIK/NF-kappaB signaling; GO:0038093 Fc receptor signaling pathway; GO:0038095 Fc-epsilon receptor signaling pathway; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I; GO:0042592 homeostatic process; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045601 regulation of endothelial cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046686 response to cadmium ion; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048872 homeostasis of number of cells; GO:0050688 regulation of defense response to virus; GO:0050691 regulation of defense response to virus by host; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050829 defense response to Gram-negative bacterium; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050879 multicellular organismal movement; GO:0050881 musculoskeletal movement; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051403 stress-activated MAPK cascade; GO:0051607 defense response to virus; GO:0051641 cellular localization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0060759 regulation of response to cytokine stimulus; GO:0061057 peptidoglycan recognition protein signaling pathway; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070482 response to oxygen levels; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070542 response to fatty acid; GO:0070555 response to interleukin-1; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071276 cellular response to cadmium ion; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071356 cellular response to tumor necrosis factor; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:0098542 defense response to other organism; GO:0098586 cellular response to virus; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1900424 regulation of defense response to bacterium; GO:1900426 positive regulation of defense response to bacterium; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901223 negative regulation of NIK/NF-kappaB signaling; GO:1901550 regulation of endothelial cell development; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901888 regulation of cell junction assembly; GO:1901889 negative regulation of cell junction assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903140 regulation of establishment of endothelial barrier; GO:1903347 negative regulation of bicellular tight junction assembly; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1904951 positive regulation of establishment of protein localization; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000810 regulation of bicellular tight junction assembly; GO:2001141 regulation of RNA biosynthetic process; GO:2001257 regulation of cation channel activity; GO:2001259 positive regulation of cation channel activity;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0008385 IkappaB kinase complex; GO:0009898 cytoplasmic side of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035631 CD40 receptor complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043235 receptor complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008384 IkappaB kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097110 scaffold protein binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00069; PF18397; PF12179","PF00069 Protein kinase domain; PF18397 IQBAL scaffold dimerization domain; PF12179 I-kappa-kinase-beta NEMO binding domain","T","KOG4250","TANK binding protein kinase TBK1","WP2324 AGERAGE PATHWAY;WP4480 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT;WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP5113 ANTIVIRAL AND ANTIINFLAMMATORY EFFECTS OF NRF2 ON SARSCOV2 PATHWAY;WP254 APOPTOSIS;WP1772 APOPTOSIS MODULATION AND SIGNALING;WP4788 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS;WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP4562 CANONICAL NFKB PATHWAY;WP2795 CARDIAC HYPERTROPHIC RESPONSE;WP3929 CHEMOKINE SIGNALING PATHWAY;WP4655 CYTOSOLIC DNASENSING PATHWAY;WP262 EBSTEINBARR VIRUS LMP1 SIGNALING;WP712 ESTROGEN SIGNALING PATHWAY;WP4136 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP4666 HEPATITIS B INFECTION;WP4880 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION;WP2112 IL17 SIGNALING PATHWAY;WP4754 IL18 SIGNALING PATHWAY;WP195 IL1 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP481 INSULIN SIGNALING;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP2637 INTERLEUKIN1 IL1 STRUCTURAL PATHWAY;WP2034 LEPTIN SIGNALING PATHWAY;WP3849 MAPK AND NFKB SIGNALING PATHWAYS INHIBITED BY YERSINIA YOPJ;WP382 MAPK SIGNALING PATHWAY;WP4630 MEASLES VIRUS INFECTION;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP4329 MIRNAS INVOLVEMENT IN THE IMMUNE RESPONSE IN SEPSIS;WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION;WP288 NODLIKE RECEPTOR NLR SIGNALING PATHWAY;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP4341 NONGENOMIC ACTIONS OF 125 DIHYDROXYVITAMIN D3;WP3865 NOVEL INTRACELLULAR COMPONENTS OF RIGILIKE RECEPTOR RLR PATHWAY;WP1433 NUCLEOTIDEBINDING OLIGOMERIZATION DOMAIN NOD PATHWAY;WP1434 OSTEOPONTIN SIGNALING;WP4263 PANCREATIC ADENOCARCINOMA PATHWAY;WP3617 PHOTODYNAMIC THERAPYINDUCED NFKB SURVIVAL SIGNALING;WP4172 PI3KAKT SIGNALING PATHWAY;WP2435 QUERCETIN AND NFKB AP1 INDUCED APOPTOSIS;WP3303 RAC1PAK1P38MMP2 PATHWAY;WP2018 RANKLRANK SIGNALING PATHWAY;WP4223 RAS SIGNALING;WP4481 RESISTIN AS A REGULATOR OF INFLAMMATION;WP4496 SIGNAL TRANSDUCTION THROUGH IL1R;WP4658 SMALL CELL LUNG CANCER;WP4961 STING PATHWAY IN KAWASAKILIKE DISEASE AND COVID19;WP4479 SUPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD;WP5098 TCELL ACTIVATION SARSCOV2;WP3863 TCELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY;WP3851 TLR4 SIGNALING AND TOLERANCE;WP231 TNFALPHA SIGNALING PATHWAY;WP2036 TNFRELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING PATHWAY;WP75 TOLLLIKE RECEPTOR SIGNALING PATHWAY;WP3858 TOLLLIKE RECEPTOR SIGNALING RELATED TO MYD88;WP1584 TYPE II DIABETES MELLITUS;WP4482 VITAMIN D IN INFLAMMATORY DISEASES",null,"Transcription factor","R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168638 NOD1/2 Signaling Pathway;R-HSA-168643 Nucleotide-binding domain"," leucine rich repeat containing receptor (NLR) signaling pathways;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-168927 TICAM1"," RIP1-mediated IKK complex recruitment;R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta;R-HSA-1810476 RIP-mediated NFkB activation via ZBP1;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-193639 p75NTR signals via NF-kB;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-209543 p75NTR recruits signalling complexes;R-HSA-209560 NF-kB is activated and signals survival;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation  ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-448424 Interleukin-17 signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450294 MAP kinase activation;R-HSA-5260271 Diseases of Immune System;R-HSA-5357905 Regulation of TNFR1 signaling;R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway;R-HSA-5602358 Diseases associated with the TLR signaling cascade;R-HSA-5602636 IKBKB deficiency causes SCID;R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);R-HSA-5603029 IkBA variant leads to EDA-ID;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5663205 Infectious disease;R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation;R-HSA-73887 Death Receptor Signalling;R-HSA-75893 TNF signaling;R-HSA-9020702 Interleukin-1 signaling;R-HSA-933542 TRAF6 mediated NF-kB activation;R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;R-HSA-937039 IRAK1 recruits IKK complex;R-HSA-937041 IKK complex recruitment mediated by RIP1;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-9758274 Regulation of NF-kappa B signaling;R-HSA-975871 MyD88 cascade initiated on plasma membrane;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"ALLOGRAFT REJECTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION"]
["O14925","Mitochondrial import inner membrane translocase subunit Tim23 OS=Homo sapiens OX=9606 GN=TIMM23 PE=1 SV=1","TIMM23",0.897404915,0.26406072,"nochange",8513.96,6839.3,6751.99,6660.48,6875.17,6301.71,1.217944234,0.978379743,0.965889819,0.952799075,0.98351104,0.901476088,"cytoplasm","K17794",null,null,"GO:0001101 response to acid chemical; GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007007 inner mitochondrial membrane organization; GO:0008104 protein localization; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010954 positive regulation of protein processing; GO:0014070 response to organic cyclic compound; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0019222 regulation of metabolic process; GO:0030150 protein import into mitochondrial matrix; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043200 response to amino acid; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045039 protein insertion into mitochondrial inner membrane; GO:0045184 establishment of protein localization; GO:0045862 positive regulation of proteolysis; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0065002 intracellular protein transmembrane transport; GO:0065007 biological regulation; GO:0070585 protein localization to mitochondrion; GO:0070613 regulation of protein processing; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0090150 establishment of protein localization to membrane; GO:0090151 establishment of protein localization to mitochondrial membrane; GO:0097066 response to thyroid hormone; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1903317 regulation of protein maturation; GO:1903319 positive regulation of protein maturation; GO:1905242 response to 3","3'","5-triiodo-L-thyronine; GO:1990542 mitochondrial transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005744 TIM23 mitochondrial import inner membrane translocase complex; GO:0005758 mitochondrial intermembrane space; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031304 intrinsic component of mitochondrial inner membrane; GO:0031305 integral component of mitochondrial inner membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0032991 protein-containing complex; GO:0042719 mitochondrial intermembrane space protein transporter complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098573 intrinsic component of mitochondrial membrane; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:1990351 transporter complex;","GO:0005048 signal sequence binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008320 protein transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015450 protein-transporting ATPase activity; GO:0019899 enzyme binding; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022884 macromolecule transmembrane transporter activity; GO:0030943 mitochondrion targeting sequence binding; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0042887 amide transmembrane transporter activity; GO:1904680 peptide transmembrane transporter activity;",null,null,"U","KOG3324","Mitochondrial import inner membrane translocase"," subunit TIM23",{"$nulls":3},"R-HSA-1268020 Mitochondrial protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1268020;https://reactome.org/PathwayBrowser/#/R-HSA-9609507"]
["O14929","Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2","HAT1",1.203641706,0.002310527,"up",97667.3,96135.8,100861,120108,121601,112961,0.902468852,0.888317432,0.931979392,1.109826205,1.123621877,1.043786242,"cytoplasm","K11303","HAT1; histone acetyltransferase 1 [EC:2.3.1.48]","hsa04613 Neutrophil extracellular trap formation; hsa05034 Alcoholism","GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006334 nucleosome assembly; GO:0006335 DNA replication-dependent chromatin assembly; GO:0006336 DNA replication-independent chromatin assembly; GO:0006338 chromatin remodeling; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007584 response to nutrient; GO:0008152 metabolic process; GO:0009605 response to external stimulus; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0031055 chromatin remodeling at centromere; GO:0031497 chromatin assembly; GO:0031667 response to nutrient levels; GO:0034080 CENP-A containing chromatin assembly; GO:0034508 centromere complex assembly; GO:0034723 DNA replication-dependent chromatin organization; GO:0034724 DNA replication-independent chromatin organization; GO:0034728 nucleosome organization; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043486 histone exchange; GO:0043543 protein acylation; GO:0043933 protein-containing complex organization; GO:0043967 histone H4 acetylation; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0050896 response to stimulus; GO:0051276 chromosome organization; GO:0061641 CENP-A containing chromatin organization; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:1901564 organonitrogen compound metabolic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0016363 nuclear matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004402 histone acetyltransferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008080 N-acetyltransferase activity; GO:0010485 H4 histone acetyltransferase activity; GO:0016407 acetyltransferase activity; GO:0016410 N-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0034212 peptide N-acetyltransferase activity; GO:0042393 histone binding; GO:0061733 peptide-lysine-N-acetyltransferase activity;","PF10394","PF10394 Histone acetyl transferase HAT1 N-terminus","B","KOG2696","Histone acetyltransferase type b catalytic subunit","WP3996 ETHANOL EFFECTS ON HISTONE MODIFICATIONS","http://www.wikipathways.org/instance/WP3996_r107156",null,"R-HSA-3214847 HATs acetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214847;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4","UBE2L6",0.879767144,0.22264762,"nochange",8118.6,8863.9,8482.17,7995.4,6188.3,8219.28,1.017630905,1.111050992,1.06320281,1.002188326,0.775676266,1.030250702,"cytoplasm","K04553","UBE2L6; ubiquitin-conjugating enzyme E2 L6 [EC:2.3.2.23]","hsa05022 Pathways of neurodegeneration - multiple diseases; hsa04120 Ubiquitin mediated proteolysis; hsa05012 Parkinson disease","GO:0000731 DNA synthesis involved in DNA repair; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006301 postreplication repair; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0016567 protein ubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019985 translesion synthesis; GO:0030163 protein catabolic process; GO:0032020 ISG15-protein conjugation; GO:0032446 protein modification by small protein conjugation; GO:0032479 regulation of type I interferon production; GO:0032480 negative regulation of type I interferon production; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071897 DNA biosynthetic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0032182 ubiquitin-like protein binding; GO:0042296 ISG15 transferase activity; GO:0043130 ubiquitin binding; GO:0140096 catalytic activity"," acting on a protein;","PF00179","PF00179 Ubiquitin-conjugating enzyme","O","KOG0422","Ubiquitin-protein ligase","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP2371 PARKINSONS DISEASE PATHWAY;WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY","http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP2371_r119919;http://www.wikipathways.org/instance/WP2359_r119918",null,"R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template;R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta;R-HSA-392499 Metabolism of proteins;R-HSA-5656169 Termination of translesion DNA synthesis;R-HSA-73893 DNA Damage Bypass;R-HSA-73894 DNA Repair;R-HSA-913531 Interferon Signaling;R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling;R-HSA-977225 Amyloid fiber formation;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-110313;https://reactome.org/PathwayBrowser/#/R-HSA-1169408;https://reactome.org/PathwayBrowser/#/R-HSA-1169410;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168928;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5656169;https://reactome.org/PathwayBrowser/#/R-HSA-73893;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-913531;https://reactome.org/PathwayBrowser/#/R-HSA-936440;https://reactome.org/PathwayBrowser/#/R-HSA-977225;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169","FATTY ACID METABOLISM;INTERFERON ALPHA RESPONSE;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["O14949","Cytochrome b-c1 complex subunit 8 OS=Homo sapiens OX=9606 GN=UQCRQ PE=1 SV=4","UQCRQ",0.914362694,0.321234107,"nochange",10942.5,13488.1,10903.3,11214.6,10228.8,10864.6,0.970626195,1.196427067,0.96714906,0.994762122,0.90731928,0.963716276,"mitochondria","K00418","QCR8; ubiquinol-cytochrome c reductase subunit 8","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04260 Cardiac muscle contraction; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006122 mitochondrial electron transport"," ubiquinol to cytochrome c; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0021536 diencephalon development; GO:0021537 telencephalon development; GO:0021539 subthalamus development; GO:0021543 pallium development; GO:0021548 pons development; GO:0021549 cerebellum development; GO:0021680 cerebellar Purkinje cell layer development; GO:0021695 cerebellar cortex development; GO:0021761 limbic system development; GO:0021766 hippocampus development; GO:0021794 thalamus development; GO:0021854 hypothalamus development; GO:0021859 pyramidal neuron differentiation; GO:0021860 pyramidal neuron development; GO:0021872 forebrain generation of neurons; GO:0021879 forebrain neuron differentiation; GO:0021884 forebrain neuron development; GO:0021953 central nervous system neuron differentiation; GO:0021954 central nervous system neuron development; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030900 forebrain development; GO:0030901 midbrain development; GO:0030902 hindbrain development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060322 head development; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005750 mitochondrial respiratory chain complex III; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045275 respiratory chain complex III; GO:0070069 cytochrome complex; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0008121 ubiquinol-cytochrome-c reductase activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016679 oxidoreductase activity"," acting on diphenols and related substances as donors; GO:0048038 quinone binding; GO:0048039 ubiquinone binding;",null,null,"C","KOG4116","Ubiquinol cytochrome c reductase"," subunit QCR8","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4921 MITOCHONDRIAL COMPLEX III ASSEMBLY;WP4396 NONALCOHOLIC FATTY LIVER DISEASE","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4921_r116643;http://www.wikipathways.org/instance/WP4396_r98945",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105","ADIPOGENESIS;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O14950","Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2","MYL12B",1.213494061,0.000444938,"up",184664,194185,195537,233183,231036,232795,0.871467673,0.916399245,0.922779613,1.100438886,1.090306748,1.098607834,"mitochondria","K12757","MYL12; myosin regulatory light chain 12","hsa04510 Focal adhesion; hsa04360 Axon guidance; hsa04530 Tight junction; hsa05131 Shigellosis; hsa05132 Salmonella infection; hsa04810 Regulation of actin cytoskeleton; hsa04670 Leukocyte transendothelial migration; hsa04611 Platelet activation","GO:0003008 system process; GO:0003012 muscle system process; GO:0006936 muscle contraction; GO:0008360 regulation of cell shape; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0032501 multicellular organismal process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality;","GO:0001725 stress fiber; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005903 brush border; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0016459 myosin complex; GO:0016460 myosin II complex; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0031674 I band; GO:0032432 actin filament bundle; GO:0032991 protein-containing complex; GO:0042641 actomyosin; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0045177 apical part of cell; GO:0071944 cell periphery; GO:0097517 contractile actin filament bundle; GO:0098862 cluster of actin-based cell projections; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region;","GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0017022 myosin binding; GO:0032036 myosin heavy chain binding;","PF13405; PF08976","PF13405 EF-hand domain; PF08976 EF-hand domain","Z","KOG0031","Myosin regulatory light chain"," EF-Hand protein superfamily","WP306 FOCAL ADHESION;WP2032 THYROID STIMULATING HORMONE TSH SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP2032_r120723",null,"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-373755 Semaphorin interactions;R-HSA-3928663 EPHA-mediated growth cone collapse;R-HSA-397014 Muscle contraction;R-HSA-400685 Sema4D in semaphorin signaling;R-HSA-416572 Sema4D induced cell migration and growth-cone collapse;R-HSA-422475 Axon guidance;R-HSA-445355 Smooth Muscle Contraction;R-HSA-5625740 RHO GTPases activate PKNs;R-HSA-5625900 RHO GTPases activate CIT;R-HSA-5627117 RHO GTPases Activate ROCKs;R-HSA-5627123 RHO GTPases activate PAKs;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-373755;https://reactome.org/PathwayBrowser/#/R-HSA-3928663;https://reactome.org/PathwayBrowser/#/R-HSA-397014;https://reactome.org/PathwayBrowser/#/R-HSA-400685;https://reactome.org/PathwayBrowser/#/R-HSA-416572;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-445355;https://reactome.org/PathwayBrowser/#/R-HSA-5625740;https://reactome.org/PathwayBrowser/#/R-HSA-5625900;https://reactome.org/PathwayBrowser/#/R-HSA-5627117;https://reactome.org/PathwayBrowser/#/R-HSA-5627123;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","ANDROGEN RESPONSE;APICAL JUNCTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION"]
["O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1","HGS",1.017977408,0.635133191,"nochange",22428.3,21239,20046,21688.3,22190.4,20980,1.046649348,0.991148928,0.935475842,1.012116168,1.035547398,0.979062315,"nucleus","K12182","HGS; hepatocyte growth factor-regulated tyrosine kinase substrate","hsa04145 Phagosome; hsa03250 Viral life cycle - HIV-1; hsa04144 Endocytosis","GO:0000003 reproduction; GO:0001505 regulation of neurotransmitter levels; GO:0001667 ameboidal-type cell migration; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006508 proteolysis; GO:0006605 protein targeting; GO:0006622 protein targeting to lysosome; GO:0006623 protein targeting to vacuole; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006914 autophagy; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0008293 torso signaling pathway; GO:0008333 endosome to lysosome transport; GO:0008592 regulation of Toll signaling pathway; GO:0008593 regulation of Notch signaling pathway; GO:0009056 catabolic process; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010324 membrane invagination; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway; GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016082 synaptic vesicle priming; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0016322 neuron remodeling; GO:0016477 cell migration; GO:0016482 cytosolic transport; GO:0016525 negative regulation of angiogenesis; GO:0017156 calcium-ion regulated exocytosis; GO:0017157 regulation of exocytosis; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0023061 signal release; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway; GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032456 endocytic recycling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032509 endosome transport via multivesicular body sorting pathway; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033619 membrane protein proteolysis; GO:0034613 cellular protein localization; GO:0036257 multivesicular body organization; GO:0036258 multivesicular body assembly; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040036 regulation of fibroblast growth factor receptor signaling pathway; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042551 neuron maturation; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043405 regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044703 multi-organism reproductive process; GO:0045022 early endosome to late endosome transport; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway; GO:0045752 positive regulation of Toll signaling pathway; GO:0045765 regulation of angiogenesis; GO:0045859 regulation of protein kinase activity; GO:0045921 positive regulation of exocytosis; GO:0045936 negative regulation of phosphate metabolic process; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048489 synaptic vesicle transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061356 regulation of Wnt protein secretion; GO:0061357 positive regulation of Wnt protein secretion; GO:0061462 protein localization to lysosome; GO:0061512 protein localization to cilium; GO:0061919 process utilizing autophagic mechanism; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071695 anatomical structure maturation; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071985 multivesicular body sorting pathway; GO:0072594 establishment of protein localization to organelle; GO:0072657 protein localization to membrane; GO:0072665 protein localization to vacuole; GO:0072666 establishment of protein localization to vacuole; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090288 negative regulation of cellular response to growth factor stimulus; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0097499 protein localization to non-motile cilium; GO:0097734 extracellular exosome biogenesis; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0098927 vesicle-mediated transport between endosomal compartments; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:0140112 extracellular vesicle biogenesis; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903541 regulation of exosomal secretion; GO:1903543 positive regulation of exosomal secretion; GO:1904892 regulation of receptor signaling pathway via STAT; GO:1904893 negative regulation of receptor signaling pathway via STAT; GO:1904951 positive regulation of establishment of protein localization; GO:1990182 exosomal secretion; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2000274 regulation of epithelial cell migration"," open tracheal system; GO:2001141 regulation of RNA biosynthetic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005771 multivesicular body; GO:0005773 vacuole; GO:0005829 cytosol; GO:0008021 synaptic vesicle; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030141 secretory granule; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0032585 multivesicular body membrane; GO:0032991 protein-containing complex; GO:0033565 ESCRT-0 complex; GO:0036452 ESCRT complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098793 presynapse; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0032182 ubiquitin-like protein binding; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0042802 identical protein binding; GO:0043130 ubiquitin binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0140030 modification-dependent protein binding; GO:0140035 ubiquitination-like modification-dependent protein binding; GO:0140036 ubiquitin-dependent protein binding; GO:1901981 phosphatidylinositol phosphate binding;","PF00790; PF01363; PF12210","PF00790 VHS domain; PF01363 FYVE zinc finger; PF12210 Hepatocyte growth factor-regulated tyrosine kinase substrate","TU","KOG1818","Membrane trafficking and cell signaling protein HRS"," contains VHS and FYVE domains","WP437 EGFEGFR SIGNALING PATHWAY;WP4301 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS;WP366 TGFBETA SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP4301_r97800;http://www.wikipathways.org/instance/WP366_r120697;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-177929 Signaling by EGFR;R-HSA-182971 EGFR downregulation;R-HSA-194315 Signaling by Rho GTPases;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-392499 Metabolism of proteins;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6806834 Signaling by MET;R-HSA-6807004 Negative regulation of MET activity;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell;R-HSA-8876384 Listeria monocytogenes entry into host cells;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT);R-HSA-9635486 Infection with Mycobacterium tuberculosis;R-HSA-9635644 Inhibition of membrane repair;R-HSA-9636383 Prevention of phagosomal-lysosomal fusion;R-HSA-9637687 Suppression of phagosomal maturation;R-HSA-9637690 Response of Mtb to phagocytosis;R-HSA-9706019 RHOBTB3 ATPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-177929;https://reactome.org/PathwayBrowser/#/R-HSA-182971;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-432720;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689880;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6806834;https://reactome.org/PathwayBrowser/#/R-HSA-6807004;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-8875360;https://reactome.org/PathwayBrowser/#/R-HSA-8876384;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-917729;https://reactome.org/PathwayBrowser/#/R-HSA-9635486;https://reactome.org/PathwayBrowser/#/R-HSA-9635644;https://reactome.org/PathwayBrowser/#/R-HSA-9636383;https://reactome.org/PathwayBrowser/#/R-HSA-9637687;https://reactome.org/PathwayBrowser/#/R-HSA-9637690;https://reactome.org/PathwayBrowser/#/R-HSA-9706019;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O14965","Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3","AURKA",0.95630857,0.729512941,"nochange",2557.56,2630.34,3280.58,2153.98,3036.47,2908.03,0.926262875,0.952621362,1.188116589,0.780099668,1.099708094,1.053191412,"cytoplasm","K11481","AURKA; aurora kinase A [EC:2.7.11.1]","hsa04914 Progesterone-mediated oocyte maturation; hsa04114 Oocyte meiosis","GO:0000003 reproduction; GO:0000022 mitotic spindle elongation; GO:0000070 mitotic sister chromatid segregation; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000212 meiotic spindle organization; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0000902 cell morphogenesis; GO:0000910 cytokinesis; GO:0001709 cell fate determination; GO:0001889 liver development; GO:0002902 regulation of B cell apoptotic process; GO:0002903 negative regulation of B cell apoptotic process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006417 regulation of translation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006977 DNA damage response"," signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007056 spindle assembly involved in female meiosis; GO:0007057 spindle assembly involved in female meiosis I; GO:0007059 chromosome segregation; GO:0007088 regulation of mitotic nuclear division; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007098 centrosome cycle; GO:0007100 mitotic centrosome separation; GO:0007127 meiosis I; GO:0007143 female meiotic nuclear division; GO:0007144 female meiosis I; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007277 pole cell development; GO:0007279 pole cell formation; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007349 cellularization; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008608 attachment of spindle microtubules to kinetochore; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009798 axis specification; GO:0009838 abscission; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010324 membrane invagination; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016310 phosphorylation; GO:0016570 histone modification; GO:0016572 histone phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018107 peptidyl-threonine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0018210 peptidyl-threonine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030010 establishment of cell polarity; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030261 chromosome condensation; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0031023 microtubule organizing center organization; GO:0031099 regeneration; GO:0031100 animal organ regeneration; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0031647 regulation of protein stability; GO:0031991 regulation of actomyosin contractile ring contraction; GO:0032091 negative regulation of protein binding; GO:0032204 regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032212 positive regulation of telomere maintenance via telomerase; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032355 response to estradiol; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032465 regulation of cytokinesis; GO:0032466 negative regulation of cytokinesis; GO:0032467 positive regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032506 cytokinetic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032886 regulation of microtubule-based process; GO:0032954 regulation of cytokinetic process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034501 protein localization to kinetochore; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0034644 cellular response to UV; GO:0035404 histone-serine phosphorylation; GO:0035556 intracellular signal transduction; GO:0036089 cleavage furrow formation; GO:0036211 protein modification process; GO:0040007 growth; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042770 signal transduction in response to DNA damage; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043988 histone H3-S28 phosphorylation; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044380 protein localization to cytoskeleton; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0044839 cell cycle G2/M phase transition; GO:0044878 mitotic cytokinesis checkpoint signaling; GO:0045165 cell fate commitment; GO:0045167 asymmetric protein localization involved in cell fate determination; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045727 positive regulation of translation; GO:0045732 positive regulation of protein catabolic process; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045840 positive regulation of mitotic nuclear division; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046605 regulation of centrosome cycle; GO:0046777 protein autophosphorylation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048732 gland development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051231 spindle elongation; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051255 spindle midzone assembly; GO:0051256 mitotic spindle midzone assembly; GO:0051257 meiotic spindle midzone assembly; GO:0051276 chromosome organization; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051299 centrosome separation; GO:0051301 cell division; GO:0051302 regulation of cell division; GO:0051321 meiotic cell cycle; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051445 regulation of meiotic cell cycle; GO:0051446 positive regulation of meiotic cell cycle; GO:0051493 regulation of cytoskeleton organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051649 establishment of localization in cell; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0051782 negative regulation of cell division; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051972 regulation of telomerase activity; GO:0051973 positive regulation of telomerase activity; GO:0051983 regulation of chromosome segregation; GO:0060255 regulation of macromolecule metabolic process; GO:0060281 regulation of oocyte development; GO:0060282 positive regulation of oocyte development; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060548 negative regulation of cell death; GO:0060560 developmental growth involved in morphogenesis; GO:0061008 hepaticobiliary system development; GO:0061024 membrane organization; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0061842 microtubule organizing center localization; GO:0061982 meiosis I cell cycle process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070228 regulation of lymphocyte apoptotic process; GO:0070229 negative regulation of lymphocyte apoptotic process; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071103 DNA conformation change; GO:0071214 cellular response to abiotic stimulus; GO:0071459 protein localization to chromosome"," centromeric region; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071539 protein localization to centrosome; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0072698 protein localization to microtubule cytoskeleton; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090306 meiotic spindle assembly; GO:0090307 mitotic spindle assembly; GO:0097421 liver regeneration; GO:0098725 symmetric cell division; GO:0098813 nuclear chromosome segregation; GO:0099024 plasma membrane invagination; GO:0104004 cellular response to environmental stimulus; GO:0110020 regulation of actomyosin structure organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1900193 regulation of oocyte maturation; GO:1900195 positive regulation of oocyte maturation; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901700 response to oxygen-containing compound; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903429 regulation of cell maturation; GO:1903431 positive regulation of cell maturation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation; GO:1904146 positive regulation of meiotic cell cycle process involved in oocyte maturation; GO:1904353 regulation of telomere capping; GO:1904355 positive regulation of telomere capping; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904358 positive regulation of telomere maintenance via telomere lengthening; GO:1904375 regulation of protein localization to cell periphery; GO:1904776 regulation of protein localization to cell cortex; GO:1905508 protein localization to microtubule organizing center; GO:1905879 regulation of oogenesis; GO:1905881 positive regulation of oogenesis; GO:1990138 neuron projection extension; GO:2000026 regulation of multicellular organismal development; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000106 regulation of leukocyte apoptotic process; GO:2000107 negative regulation of leukocyte apoptotic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process; GO:2000278 regulation of DNA biosynthetic process; GO:2000573 positive regulation of DNA biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000922 spindle pole; GO:0001674 female germ cell nucleus; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005876 spindle microtubule; GO:0015630 microtubule cytoskeleton; GO:0030424 axon; GO:0030496 midbody; GO:0031616 spindle pole centrosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032133 chromosome passenger complex; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042585 germinal vesicle; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043073 germ cell nucleus; GO:0043203 axon hillock; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045120 pronucleus; GO:0048471 perinuclear region of cytoplasm; GO:0051233 spindle midzone; GO:0070013 intracellular organelle lumen; GO:0070938 contractile ring; GO:0072686 mitotic spindle; GO:0072687 meiotic spindle; GO:0097431 mitotic spindle pole; GO:0098687 chromosomal region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004712 protein serine/threonine/tyrosine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0031625 ubiquitin protein ligase binding; GO:0035173 histone kinase activity; GO:0035174 histone serine kinase activity; GO:0044389 ubiquitin-like protein ligase binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0051117 ATPase binding; GO:0140096 catalytic activity"," acting on a protein;","PF00069","PF00069 Protein kinase domain","D","KOG0580","Serine/threonine protein kinase","WP437 EGFEGFR SIGNALING PATHWAY;WP2361 GASTRIC CANCER NETWORK 1","http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP2361_r117731",null,"R-HSA-1640170 Cell Cycle;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-212436 Generic Transcription Pathway;R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-392499 Metabolism of proteins;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-4615885 SUMOylation of DNA replication proteins;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-597592 Post-translational protein modification;R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes;R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8854518 AURKA Activation by TPX2;R-HSA-8854521 Interaction between PHLDA1 and AURKA","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-174143;https://reactome.org/PathwayBrowser/#/R-HSA-174178;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2565942;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-453274;https://reactome.org/PathwayBrowser/#/R-HSA-453276;https://reactome.org/PathwayBrowser/#/R-HSA-4615885;https://reactome.org/PathwayBrowser/#/R-HSA-5633007;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6791312;https://reactome.org/PathwayBrowser/#/R-HSA-6804114;https://reactome.org/PathwayBrowser/#/R-HSA-6804756;https://reactome.org/PathwayBrowser/#/R-HSA-69275;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8854050;https://reactome.org/PathwayBrowser/#/R-HSA-8854518;https://reactome.org/PathwayBrowser/#/R-HSA-8854521","E2F TARGETS;G2M CHECKPOINT;GLYCOLYSIS;MITOTIC SPINDLE;MTORC1 SIGNALING;SPERMATOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_SPERMATOGENESIS"]
["O14972","Vacuolar protein sorting-associated protein 26C OS=Homo sapiens OX=9606 GN=VPS26C PE=1 SV=1","VPS26C",0.571517848,0.001016183,"down",8445.73,8005.39,9775.55,5123.35,4745.27,5120.39,1.229492756,1.165389968,1.423082186,0.74583508,0.690795833,0.745404176,"cytoplasm","K25730",null,null,"GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030904 retromer complex; GO:0030906 retromer"," cargo-selective complex; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0097708 intracellular vesicle; GO:0098796 membrane protein complex;","GO:0005215 transporter activity;",null,null,"R","KOG2717","Uncharacterized conserved protein with similarity to embryogenesis protein H beta 58 and VPS26"]
["O14974","Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1","PPP1R12A",1.561040463,{"v":1.77745e-05,"d":"1.78E-05"},"up",39578.4,41816.6,40043.3,62539.4,62844.2,64186.5,0.763549795,0.806729336,0.772518684,1.206515322,1.212395549,1.238291313,"nucleus","K06270","PPP1R12A; protein phosphatase 1 regulatory subunit 12A","hsa04510 Focal adhesion; hsa04270 Vascular smooth muscle contraction; hsa04921 Oxytocin signaling pathway; hsa04810 Regulation of actin cytoskeleton; hsa04024 cAMP signaling pathway; hsa05205 Proteoglycans in cancer; hsa04611 Platelet activation; hsa04022 cGMP-PKG signaling pathway","GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001889 liver development; GO:0002009 morphogenesis of an epithelium; GO:0003002 regionalization; GO:0003401 axis elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007098 centrosome cycle; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008045 motor neuron axon guidance; GO:0008152 metabolic process; GO:0008360 regulation of cell shape; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010921 regulation of phosphatase activity; GO:0010922 positive regulation of phosphatase activity; GO:0016043 cellular component organization; GO:0016311 dephosphorylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0021532 neural tube patterning; GO:0021555 midbrain-hindbrain boundary morphogenesis; GO:0021903 rostrocaudal neural tube patterning; GO:0021915 neural tube development; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030182 neuron differentiation; GO:0030917 midbrain-hindbrain boundary development; GO:0031023 microtubule organizing center organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032516 positive regulation of phosphoprotein phosphatase activity; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0035295 tube development; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035306 positive regulation of dephosphorylation; GO:0035307 positive regulation of protein dephosphorylation; GO:0035507 regulation of myosin-light-chain-phosphatase activity; GO:0035508 positive regulation of myosin-light-chain-phosphatase activity; GO:0036211 protein modification process; GO:0040007 growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046822 regulation of nucleocytoplasmic transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051017 actin filament bundle assembly; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0060026 convergent extension; GO:0060028 convergent extension involved in axis elongation; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060560 developmental growth involved in morphogenesis; GO:0061008 hepaticobiliary system development; GO:0061564 axon development; GO:0061572 actin filament bundle organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070650 actin filament bundle distribution; GO:0070887 cellular response to chemical stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901564 organonitrogen compound metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0008287 protein serine/threonine phosphatase complex; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0031672 A band; GO:0031674 I band; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0070013 intracellular organelle lumen; GO:0072357 PTW/PP1 phosphatase complex; GO:0098687 chromosomal region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:1902494 catalytic complex; GO:1903293 phosphatase complex;","GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0019208 phosphatase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0042578 phosphoric ester hydrolase activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0071889 14-3-3 protein binding; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;",null,null,"OT","KOG0505","Myosin phosphatase"," regulatory subunit","WP4861 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION;WP306 FOCAL ADHESION;WP4541 HIPPOMERLIN SIGNALING DYSREGULATION;WP51 REGULATION OF ACTIN CYTOSKELETON","http://www.wikipathways.org/instance/WP4861_r118973;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP4541_r116745;http://www.wikipathways.org/instance/WP51_r116716",null,"R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-5625740 RHO GTPases activate PKNs;R-HSA-5625900 RHO GTPases activate CIT;R-HSA-5627117 RHO GTPases Activate ROCKs;R-HSA-5627123 RHO GTPases activate PAKs;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2565942;https://reactome.org/PathwayBrowser/#/R-HSA-453274;https://reactome.org/PathwayBrowser/#/R-HSA-5625740;https://reactome.org/PathwayBrowser/#/R-HSA-5625900;https://reactome.org/PathwayBrowser/#/R-HSA-5627117;https://reactome.org/PathwayBrowser/#/R-HSA-5627123;https://reactome.org/PathwayBrowser/#/R-HSA-69275;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O14975","Long-chain fatty acid transport protein 2 OS=Homo sapiens OX=9606 GN=SLC27A2 PE=1 SV=2","SLC27A2",1.10805152,0.018899918,"nochange",25642.6,26547,25279,28104.1,29907.4,27827.7,0.94212034,0.975348391,0.928761517,1.032556926,1.098810957,1.022401869,"endoplasmic reticulum","K08746","SLC27A2; solute carrier family 27 (fatty acid transporter)"," member 2 [EC:6.2.1.- 6.2.1.3]","hsa03320 PPAR signaling pathway; hsa04146 Peroxisome; hsa04931 Insulin resistance","GO:0000038 very long-chain fatty acid metabolic process; GO:0001561 fatty acid alpha-oxidation; GO:0001676 long-chain fatty acid metabolic process; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006082 organic acid metabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006694 steroid biosynthetic process; GO:0006699 bile acid biosynthetic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008206 bile acid metabolic process; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0015031 protein transport; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015721 bile acid and bile salt transport; GO:0015833 peptide transport; GO:0015849 organic acid transport; GO:0015850 organic hydroxy compound transport; GO:0015908 fatty acid transport; GO:0015909 long-chain fatty acid transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0016054 organic acid catabolic process; GO:0016192 vesicle-mediated transport; GO:0019395 fatty acid oxidation; GO:0019752 carboxylic acid metabolic process; GO:0030258 lipid modification; GO:0032787 monocarboxylic acid metabolic process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034220 ion transmembrane transport; GO:0034440 lipid oxidation; GO:0034613 cellular protein localization; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042760 very long-chain fatty acid catabolic process; GO:0042886 amide transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0044539 long-chain fatty acid import into cell; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0046394 carboxylic acid biosynthetic process; GO:0046395 carboxylic acid catabolic process; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0046942 carboxylic acid transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0097089 methyl-branched fatty acid metabolic process; GO:0098656 anion transmembrane transport; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1903825 organic acid transmembrane transport; GO:1905039 carboxylic acid transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005779 integral component of peroxisomal membrane; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031231 intrinsic component of peroxisomal membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031903 microbody membrane; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0035579 specific granule membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042579 microbody; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098827 endoplasmic reticulum subcompartment; GO:0099503 secretory vesicle;","GO:0003824 catalytic activity; GO:0004467 long-chain fatty acid-CoA ligase activity; GO:0005102 signaling receptor binding; GO:0005215 transporter activity; GO:0005319 lipid transporter activity; GO:0005342 organic acid transmembrane transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008028 monocarboxylic acid transmembrane transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015245 fatty acid transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015645 fatty acid ligase activity; GO:0016405 CoA-ligase activity; GO:0016874 ligase activity; GO:0016877 ligase activity"," forming carbon-sulfur bonds; GO:0016878 acid-thiol ligase activity; GO:0019899 enzyme binding; GO:0022857 transmembrane transporter activity; GO:0031957 very long-chain fatty acid-CoA ligase activity; GO:0046943 carboxylic acid transmembrane transporter activity; GO:0050197 phytanate-CoA ligase activity; GO:0070251 pristanate-CoA ligase activity;","PF13193","PF13193 AMP-binding enzyme C-terminal domain","I","KOG1179","Very long-chain acyl-CoA synthetase/fatty acid transporter","WP5064 7OXOC AND 7BETAHC PATHWAYS;WP4545 OXYSTEROLS DERIVED FROM CHOLESTEROL;WP3942 PPAR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5064_r120384;http://www.wikipathways.org/instance/WP4545_r120411;http://www.wikipathways.org/instance/WP3942_r106517",null,"R-HSA-1430728 Metabolism;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-192105 Synthesis of bile acids and bile salts;R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol;R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol;R-HSA-194068 Bile acid and bile salt metabolism;R-HSA-389599 Alpha-oxidation of phytanate;R-HSA-390918 Peroxisomal lipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-6798695 Neutrophil degranulation;R-HSA-75105 Fatty acyl-CoA biosynthesis;R-HSA-8957322 Metabolism of steroids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-192105;https://reactome.org/PathwayBrowser/#/R-HSA-193368;https://reactome.org/PathwayBrowser/#/R-HSA-193775;https://reactome.org/PathwayBrowser/#/R-HSA-194068;https://reactome.org/PathwayBrowser/#/R-HSA-389599;https://reactome.org/PathwayBrowser/#/R-HSA-390918;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-75105;https://reactome.org/PathwayBrowser/#/R-HSA-8957322;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","BILE ACID METABOLISM;ESTROGEN RESPONSE EARLY;ESTROGEN RESPONSE LATE;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["O14976","Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2","GAK",0.581778662,{"v":1.02857E-5,"d":"1.03E-05"},"down",15582.6,16319.7,15553.6,9292.56,9327.65,8988.62,1.245533022,1.304450173,1.243215023,0.742763745,0.745568525,0.718469513,"plasma membrane","K08855",null,null,"GO:0000003 reproduction; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001889 liver development; GO:0003006 developmental process involved in reproduction; GO:0006457 protein folding; GO:0006458 'de novo' protein folding; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006896 Golgi to vacuole transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007030 Golgi organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007291 sperm individualization; GO:0007349 cellularization; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008544 epidermis development; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009913 epidermal cell differentiation; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010721 negative regulation of cell development; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016191 synaptic vesicle uncoating; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016482 cytosolic transport; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030104 water homeostasis; GO:0030154 cell differentiation; GO:0030855 epithelial cell differentiation; GO:0030900 forebrain development; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033561 regulation of water loss via skin; GO:0034067 protein localization to Golgi apparatus; GO:0034613 cellular protein localization; GO:0035295 tube development; GO:0035622 intrahepatic bile duct development; GO:0036211 protein modification process; GO:0036465 synaptic vesicle recycling; GO:0042127 regulation of cell population proliferation; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043588 skin development; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048488 synaptic vesicle endocytosis; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048592 eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048732 gland development; GO:0048749 compound eye development; GO:0048853 forebrain morphogenesis; GO:0048854 brain morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0048878 chemical homeostasis; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050878 regulation of body fluid levels; GO:0050891 multicellular organismal water homeostasis; GO:0050896 response to stimulus; GO:0051084 'de novo' posttranslational protein folding; GO:0051085 chaperone cofactor-dependent protein refolding; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051261 protein depolymerization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0061008 hepaticobiliary system development; GO:0061009 common bile duct development; GO:0061024 membrane organization; GO:0061077 chaperone-mediated protein folding; GO:0061436 establishment of skin barrier; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072318 clathrin coat disassembly; GO:0072319 vesicle uncoating; GO:0072583 clathrin-dependent endocytosis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0090160 Golgi to lysosome transport; GO:0090596 sensory organ morphogenesis; GO:0098657 import into cell; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1905224 clathrin-coated pit assembly; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000177 regulation of neural precursor cell proliferation; GO:2000179 positive regulation of neural precursor cell proliferation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0030332 cyclin binding; GO:0051087 chaperone binding; GO:0140096 catalytic activity"," acting on a protein;","PF00069; PF10409","PF00069 Protein kinase domain; PF10409 C2 domain of PTEN tumour-suppressor protein","TR","KOG2283","Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828"]
["O14979","Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3","HNRNPDL",1.280730179,0.001207955,"up",109126,117953,119795,149323,149548,145381,0.827625435,0.894570524,0.908540485,1.132484585,1.134191014,1.102587957,"nucleus","K13044",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0035722 interleukin-12-mediated signaling pathway; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070671 response to interleukin-12; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071349 cellular response to interleukin-12; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003697 single-stranded DNA binding; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0005488 binding; GO:0008143 poly(A) binding; GO:0034046 poly(G) binding; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","R","KOG0118","FOG: RRM domain",{"$nulls":3},"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-168256 Immune System;R-HSA-447115 Interleukin-12 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;R-HSA-9020591 Interleukin-12 signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-447115;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-8950505;https://reactome.org/PathwayBrowser/#/R-HSA-9020591"]
["O14980","Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1","XPO1",0.855867759,0.003033597,"down",63985.3,63804.3,63400.1,55391,51981.2,56260.9,1.081981767,1.078921084,1.072086123,0.936653451,0.878994247,0.951363328,"cytoplasm","K14290","XPO1; exportin-1","hsa03008 Ribosome biogenesis in eukaryotes; hsa03013 Nucleocytoplasmic transport; hsa03250 Viral life cycle - HIV-1; hsa05164 Influenza A; hsa05166 Human T-cell leukemia virus 1 infection","GO:0000054 ribosomal subunit export from nucleus; GO:0000055 ribosomal large subunit export from nucleus; GO:0000056 ribosomal small subunit export from nucleus; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000226 microtubule cytoskeleton organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007098 centrosome cycle; GO:0007099 centriole replication; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010824 regulation of centrosome duplication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0019058 viral life cycle; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0031023 microtubule organizing center organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031503 protein-containing complex localization; GO:0032386 regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032886 regulation of microtubule-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033365 protein localization to organelle; GO:0033750 ribosome localization; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042254 ribosome biogenesis; GO:0042886 amide transport; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0044085 cellular component biogenesis; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045184 establishment of protein localization; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046605 regulation of centrosome cycle; GO:0046794 transport of virus; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046825 regulation of protein export from nucleus; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051298 centrosome duplication; GO:0051493 regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061013 regulation of mRNA catabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0075733 intracellular transport of virus; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0098534 centriole assembly; GO:1900037 regulation of cellular response to hypoxia; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005642 annulate lamellae; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0015030 Cajal body; GO:0016020 membrane; GO:0016604 nuclear body; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1990904 ribonucleoprotein complex;","GO:0005049 nuclear export signal receptor activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019904 protein domain specific binding; GO:0140104 molecular carrier activity; GO:0140142 nucleocytoplasmic carrier activity;",null,null,"YU","KOG2020","Nuclear transport receptor CRM1/MSN5 (importin beta superfamily)","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4657_r120007","Transcription factor","R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-165054 Rev-mediated nuclear export of HIV RNA;R-HSA-168255 Influenza Infection;R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus;R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-177243 Interactions of Rev with host cellular proteins;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-2173788 Downregulation of TGF-beta receptor signaling;R-HSA-2173789 TGF-beta receptor signaling activates SMADs;R-HSA-2262752 Cellular responses to stress;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-3769402 Deactivation of the beta-catenin transactivating complex;R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-5663205 Infectious disease;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-8939211 ESR-mediated signaling;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006936 Signaling by TGFB family members;R-HSA-9009391 Extra-nuclear estrogen signaling;R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9707616 Heme signaling;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3",null,"E2F TARGETS;G2M CHECKPOINT;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O14981","TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2","BTAF1",0.996458685,0.925984726,"nochange",19410.2,21010.8,20573.3,20505.8,21418.4,18854.1,0.956382635,1.035247667,1.013691093,1.010365222,1.055331002,0.928982382,"plasma membrane","K15192",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0035561 regulation of chromatin binding; GO:0035562 negative regulation of chromatin binding; GO:0044092 negative regulation of molecular function; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00176; PF00271","PF00176 SNF2-related domain; PF00271 Helicase conserved C-terminal domain","K","KOG0392","SNF2 family DNA-dependent ATPase domain-containing protein","WP2853 ENDODERM DIFFERENTIATION","http://www.wikipathways.org/instance/WP2853_r116557","Transcription factor"]
["O14986","Phosphatidylinositol 4-phosphate 5-kinase type-1 beta OS=Homo sapiens OX=9606 GN=PIP5K1B PE=1 SV=2","PIP5K1B",1.386892239,0.230172137,"nochange","NA",2568.52,2460.46,2495.69,4083.64,3882.65,"NA",0.829038355,0.794159949,0.805531097,1.318071959,1.25319864,"nucleus","K00889","PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]","hsa04666 Fc gamma R-mediated phagocytosis; hsa04510 Focal adhesion; hsa04072 Phospholipase D signaling pathway; hsa04810 Regulation of actin cytoskeleton; hsa05231 Choline metabolism in cancer; hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa04144 Endocytosis; hsa01100 Metabolic pathways; hsa05135 Yersinia infection","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0001505 regulation of neurotransmitter levels; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002376 immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007044 cell-substrate junction assembly; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007310 oocyte dorsal/ventral axis specification; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007422 peripheral nervous system development; GO:0007602 phototransduction; GO:0007603 phototransduction"," visible light; GO:0008103 oocyte microtubule cytoskeleton polarization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008544 epidermis development; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009584 detection of visible light; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009798 axis specification; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009913 epidermal cell differentiation; GO:0009950 dorsal/ventral axis specification; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010511 regulation of phosphatidylinositol biosynthetic process; GO:0010513 positive regulation of phosphatidylinositol biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0016043 cellular component organization; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016325 oocyte microtubule cytoskeleton organization; GO:0016477 cell migration; GO:0017156 calcium-ion regulated exocytosis; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023061 signal release; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030198 extracellular matrix organization; GO:0030216 keratinocyte differentiation; GO:0030258 lipid modification; GO:0030593 neutrophil chemotaxis; GO:0030595 leukocyte chemotaxis; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity; GO:0030952 establishment or maintenance of cytoskeleton polarity; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031529 ruffle organization; GO:0031532 actin cytoskeleton reorganization; GO:0031589 cell-substrate adhesion; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032886 regulation of microtubule-based process; GO:0032887 regulation of spindle elongation; GO:0032888 regulation of mitotic spindle elongation; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033127 regulation of histone phosphorylation; GO:0033128 negative regulation of histone phosphorylation; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034332 adherens junction organization; GO:0034333 adherens junction assembly; GO:0034613 cellular protein localization; GO:0036465 synaptic vesicle recycling; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0043062 extracellular structure organization; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0043588 skin development; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044703 multi-organism reproductive process; GO:0045017 glycerolipid biosynthetic process; GO:0045055 regulated exocytosis; GO:0045216 cell-cell junction organization; GO:0045834 positive regulation of lipid metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046834 lipid phosphorylation; GO:0046854 phosphatidylinositol phosphate biosynthetic process; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048041 focal adhesion assembly; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048488 synaptic vesicle endocytosis; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051606 detection of stimulus; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051983 regulation of chromosome segregation; GO:0060236 regulation of mitotic spindle organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060326 cell chemotaxis; GO:0060429 epithelium development; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071071 regulation of phospholipid biosynthetic process; GO:0071073 positive regulation of phospholipid biosynthetic process; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071621 granulocyte chemotaxis; GO:0071704 organic substance metabolic process; GO:0071711 basement membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0072583 clathrin-dependent endocytosis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0090224 regulation of spindle organization; GO:0090407 organophosphate biosynthetic process; GO:0090630 activation of GTPase activity; GO:0097178 ruffle assembly; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0097529 myeloid leukocyte migration; GO:0097530 granulocyte migration; GO:0098609 cell-cell adhesion; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0104004 cellular response to environmental stimulus; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1901576 organic substance biosynthetic process; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1903725 regulation of phospholipid metabolic process; GO:1903727 positive regulation of phospholipid metabolic process; GO:1904396 regulation of neuromuscular junction development; GO:1905268 negative regulation of chromatin organization; GO:1990266 neutrophil migration; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2001251 negative regulation of chromosome organization;","GO:0001726 ruffle; GO:0001891 phagocytic cup; GO:0001931 uropod; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005902 microvillus; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0005938 cell cortex; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016028 rhabdomere; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031254 cell trailing edge; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031528 microvillus membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032587 ruffle membrane; GO:0033583 rhabdomere membrane; GO:0035323 male germline ring canal; GO:0035996 rhabdomere microvillus; GO:0035997 rhabdomere microvillus membrane; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045171 intercellular bridge; GO:0045172 germline ring canal; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0016301 kinase activity; GO:0016307 phosphatidylinositol phosphate kinase activity; GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0052742 phosphatidylinositol kinase activity; GO:0052810 1-phosphatidylinositol-5-kinase activity; GO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity; GO:0052812 phosphatidylinositol-3","4-bisphosphate 5-kinase activity; GO:0052813 phosphatidylinositol bisphosphate kinase activity;",null,null,"T","KOG0229","Phosphatidylinositol-4-phosphate 5-kinase","WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP4971 PHOSPHOINOSITIDES METABOLISM;WP51 REGULATION OF ACTIN CYTOSKELETON;WP363 WNT SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP23_r120701;http://www.wikipathways.org/instance/WP4971_r112223;http://www.wikipathways.org/instance/WP51_r116716;http://www.wikipathways.org/instance/WP363_r120695",null,"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1430728 Metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-162582 Signal Transduction;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-195721 Signaling by WNT;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-201688 WNT mediated activation of DVL;R-HSA-556833 Metabolism of lipids;R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-9006925 Intracellular signaling by second messengers","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-199418;https://reactome.org/PathwayBrowser/#/R-HSA-201681;https://reactome.org/PathwayBrowser/#/R-HSA-201688;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-6811558;https://reactome.org/PathwayBrowser/#/R-HSA-9006925"]
["O15013","Rho guanine nucleotide exchange factor 10 OS=Homo sapiens OX=9606 GN=ARHGEF10 PE=1 SV=4","ARHGEF10",0.559484613,0.012135738,"nochange",5323.05,6263.56,5938.09,3256.62,3987.3,2560.88,1.168638285,1.375120657,1.303666002,0.714968075,0.875383743,0.562223239,"nucleus","K16727",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007098 centrosome cycle; GO:0007272 ensheathment of neurons; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007422 peripheral nervous system development; GO:0008366 axon ensheathment; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010638 positive regulation of organelle organization; GO:0014037 Schwann cell differentiation; GO:0014044 Schwann cell development; GO:0016043 cellular component organization; GO:0021782 glial cell development; GO:0022008 neurogenesis; GO:0022011 myelination in peripheral nervous system; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031023 microtubule organizing center organization; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032292 peripheral nervous system axon ensheathment; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0042063 gliogenesis; GO:0042552 myelination; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051225 spindle assembly; GO:0051298 centrosome duplication; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051496 positive regulation of stress fiber assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0090307 mitotic spindle assembly; GO:0090630 activation of GTPase activity; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0140014 mitotic nuclear division; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903047 mitotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0098772 molecular function regulator;","PF00621; PF19057","PF00621 RhoGEF domain; PF19057 PH domain","T","KOG3522","Predicted guanine nucleotide exchange factor",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-193648 NRAGE signals death through JNK;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-194315 Signaling by Rho GTPases;R-HSA-204998 Cell death signalling via NRAGE"," NRIF and NADE;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-416482 G alpha (12/13) signalling events;R-HSA-73887 Death Receptor Signalling;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-193648;https://reactome.org/PathwayBrowser/#/R-HSA-193704;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-204998;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-416482;https://reactome.org/PathwayBrowser/#/R-HSA-73887;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O15014","Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2","ZNF609",0.848145113,0.109170811,"nochange",9713.53,8045.5,8101.58,6927.64,6942.94,8062.97,1.219420532,1.010018797,1.017058988,0.869684497,0.871605234,1.012211952,"nucleus",{"$nulls":3},"GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010720 positive regulation of cell development; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0033081 regulation of T cell differentiation in thymus; GO:0033089 positive regulation of T cell differentiation in thymus; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042127 regulation of cell population proliferation; GO:0045580 regulation of T cell differentiation; GO:0045582 positive regulation of T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045621 positive regulation of lymphocyte differentiation; GO:0045785 positive regulation of cell adhesion; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000291 regulation of myoblast proliferation; GO:2001141 regulation of RNA biosynthetic process; GO:2001222 regulation of neuron migration; GO:2001224 positive regulation of neuron migration;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032039 integrator complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;"]
["O15021","Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=MAST4 PE=1 SV=4","MAST4",1.429025212,0.080210265,"nochange",3860.34,3212.27,2642.53,3711.85,4864.95,5306.38,0.981512243,0.816736954,0.67187749,0.943757861,1.236939748,1.349175704,"cytoplasm","K08789",null,null,"GO:0000003 reproduction; GO:0001667 ameboidal-type cell migration; GO:0001817 regulation of cytokine production; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007030 Golgi organization; GO:0007032 endosome organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007349 cellularization; GO:0007444 imaginal disc development; GO:0007549 dosage compensation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008361 regulation of cell size; GO:0009047 dosage compensation by hyperactivation of X chromosome; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010631 epithelial cell migration; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0018105 peptidyl-serine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031887 lipid droplet transport along microtubule; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032655 regulation of interleukin-12 production; GO:0032781 positive regulation of ATP-dependent activity; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0035220 wing disc development; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043462 regulation of ATP-dependent activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045793 positive regulation of cell size; GO:0046907 intracellular transport; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072384 organelle transport along microtubule; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0099111 microtubule-based transport; GO:1901564 organonitrogen compound metabolic process; GO:1990778 protein localization to cell periphery;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0000166 nucleotide binding; GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF08926; PF00069; PF17820","PF08926 Domain of unknown function (DUF1908); PF00069 Protein kinase domain; PF17820 PDZ domain","TR","KOG0606","Microtubule-associated serine/threonine kinase and related proteins",{"$nulls":5},"ESTROGEN RESPONSE EARLY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY"]
["O15027","Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4","SEC16A",0.58491589,1.53249E-4,"down",29748.5,29817.8,30256.7,16488.9,18785.6,17264.4,1.253783491,1.256704217,1.275202143,0.694942959,0.791739925,0.727627265,"nucleus","K20353",null,null,"GO:0003400 regulation of COPII vesicle coating; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007030 Golgi organization; GO:0007154 cell communication; GO:0008104 protein localization; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010256 endomembrane system organization; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0022607 cellular component assembly; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034198 cellular response to amino acid starvation; GO:0034613 cellular protein localization; GO:0042594 response to starvation; GO:0043254 regulation of protein-containing complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048209 regulation of vesicle targeting"," to"," from or within Golgi; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0060628 regulation of ER to Golgi vesicle-mediated transport; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070861 regulation of protein exit from endoplasmic reticulum; GO:0070863 positive regulation of protein exit from endoplasmic reticulum; GO:0070972 protein localization to endoplasmic reticulum; GO:0070973 protein localization to endoplasmic reticulum exit site; GO:0071496 cellular response to external stimulus; GO:0071840 cellular component organization or biogenesis; GO:0090087 regulation of peptide transport; GO:0090113 regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis; GO:0090114 COPII-coated vesicle budding; GO:0090316 positive regulation of intracellular protein transport; GO:1903829 positive regulation of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1990928 response to amino acid starvation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0070971 endoplasmic reticulum exit site;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding;","PF12932; PF12931","PF12932 Vesicle coat trafficking protein Sec16 mid-region; PF12931 Sec23-binding domain of Sec16","K","KOG1913","Regucalcin gene promoter region-related protein (RGPR)",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["O15031","Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3","PLXNB2",0.836740308,0.028287362,"nochange",12924.8,12350.1,11842.1,9481.79,10418.2,11157.3,1.137507996,1.086928811,1.042219875,0.834489659,0.916902838,0.98195082,"plasma membrane","K06821","PLXNB; plexin B","hsa04360 Axon guidance","GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001932 regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007405 neuroblast proliferation; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008283 cell population proliferation; GO:0008360 regulation of cell shape; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014020 primary neural tube formation; GO:0016331 morphogenesis of embryonic epithelium; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0021915 neural tube development; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022610 biological adhesion; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040012 regulation of locomotion; GO:0042325 regulation of phosphorylation; GO:0043009 chordate embryonic development; GO:0043087 regulation of GTPase activity; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0061351 neural precursor cell proliferation; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071526 semaphorin-plexin signaling pathway; GO:0072089 stem cell proliferation; GO:0072175 epithelial tube formation; GO:0080090 regulation of primary metabolic process; GO:0098609 cell-cell adhesion; GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2001222 regulation of neuron migration;","GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0071944 cell periphery;","GO:0004888 transmembrane signaling receptor activity; GO:0017154 semaphorin receptor activity; GO:0038023 signaling receptor activity; GO:0060089 molecular transducer activity;","PF17960; PF01833","PF17960 TIG domain; PF01833 IPT/TIG domain","T","KOG3610","Plexins (functional semaphorin receptors)",{"$nulls":5},"MYOGENESIS;P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O15042","U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2","U2SURP",1.118292929,0.004212785,"up",129972,131127,126067,148590,142730,141645,0.950862728,0.959312598,0.922294121,1.087070236,1.044199036,1.03626128,"nucleus","K12842","SR140; U2-associated protein SR140","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00076; PF08312","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain); PF08312 cwf21 domain","R","KOG0151","Predicted splicing regulator"," contains RRM"," SWAP and RPR domains",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O15047","Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3","SETD1A",1.217639494,0.006291125,"up",15532.5,16146.2,14744.4,17900,19600.4,19026.2,0.905247903,0.941014884,0.859316734,1.043227906,1.142328729,1.108863843,"nucleus","K11422","SETD1; [histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]","hsa00310 Lysine degradation; hsa01100 Metabolic pathways","GO:0002682 regulation of immune system process; GO:0006325 chromatin organization; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008340 determination of adult lifespan; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0018022 peptidyl-lysine methylation; GO:0018023 peptidyl-lysine trimethylation; GO:0018027 peptidyl-lysine dimethylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019538 protein metabolic process; GO:0030154 cell differentiation; GO:0032259 methylation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034968 histone lysine methylation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044648 histone H3-K4 dimethylation; GO:0045595 regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045652 regulation of megakaryocyte differentiation; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051276 chromosome organization; GO:0051568 histone H3-K4 methylation; GO:0060290 transdifferentiation; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080182 histone H3-K4 trimethylation; GO:1901532 regulation of hematopoietic progenitor cell differentiation; GO:1901564 organonitrogen compound metabolic process; GO:1902036 regulation of hematopoietic stem cell differentiation; GO:1902275 regulation of chromatin organization; GO:1903706 regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000736 regulation of stem cell differentiation;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000791 euchromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048188 Set1C/COMPASS complex; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008134 transcription factor binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016278 lysine N-methyltransferase activity; GO:0016279 protein-lysine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0018024 histone-lysine N-methyltransferase activity; GO:0042054 histone methyltransferase activity; GO:0042800 histone methyltransferase activity (H3-K4 specific); GO:0140096 catalytic activity"," acting on a protein;","PF00076; PF11764","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain); PF11764 COMPASS (Complex proteins associated with Set1p) component N","BK","KOG1080","Histone H3 (Lys4) methyltransferase complex"," subunit SET1 and related methyltransferases","WP2369 HISTONE MODIFICATIONS","http://www.wikipathways.org/instance/WP2369_r118380","Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-3214841 PKMTs methylate histone lysines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3214841;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8936459"]
["O15054","Lysine-specific demethylase 6B OS=Homo sapiens OX=9606 GN=KDM6B PE=1 SV=4","KDM6B",1.150942646,0.303455002,"nochange",1279.62,1841.92,1655.97,1921.62,1608.78,1968.24,0.747139736,1.075453356,0.966881566,1.121988293,0.939328445,1.149208604,"extracellular","K11448",null,null,"GO:0000302 response to reactive oxygen species; GO:0001704 formation of primary germ layer; GO:0001707 mesoderm formation; GO:0003158 endothelium development; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006482 protein demethylation; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007498 mesoderm development; GO:0007507 heart development; GO:0008152 metabolic process; GO:0008214 protein dealkylation; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0014706 striated muscle tissue development; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016577 histone demethylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021761 limbic system development; GO:0021766 hippocampus development; GO:0030154 cell differentiation; GO:0030855 epithelial cell differentiation; GO:0030900 forebrain development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034599 cellular response to oxidative stress; GO:0034614 cellular response to reactive oxygen species; GO:0035051 cardiocyte differentiation; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0042542 response to hydrogen peroxide; GO:0042692 muscle cell differentiation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045165 cell fate commitment; GO:0045446 endothelial cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046677 response to antibiotic; GO:0048332 mesoderm morphogenesis; GO:0048333 mesodermal cell differentiation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0055007 cardiac muscle cell differentiation; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060537 muscle tissue development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070076 histone lysine demethylation; GO:0070301 cellular response to hydrogen peroxide; GO:0070887 cellular response to chemical stimulus; GO:0070988 demethylation; GO:0071236 cellular response to antibiotic; GO:0071557 histone H3-K27 demethylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0097237 cellular response to toxic substance; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0032451 demethylase activity; GO:0032452 histone demethylase activity; GO:0043565 sequence-specific DNA binding; GO:0071558 histone H3-tri/di-methyl-lysine-27 demethylase activity; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;","PF02373","PF02373 JmjC domain"," hydroxylase","R","KOG1246","DNA-binding protein jumonji/RBP2/SMCY"," contains JmjC domain","WP3651 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA;WP4698 VITAMIN DSENSITIVE CALCIUM SIGNALING IN DEPRESSION","http://www.wikipathways.org/instance/WP3651_r116547;http://www.wikipathways.org/instance/WP4698_r119119","Transcription factor","R-HSA-2262752 Cellular responses to stress;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559583 Cellular Senescence;R-HSA-3214842 HDMs demethylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2559580;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-3214842;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-8953897","TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["O15056","Synaptojanin-2 OS=Homo sapiens OX=9606 GN=SYNJ2 PE=1 SV=3","SYNJ2",0.595575431,0.000386947,"down",5313.13,5768.68,5503.31,3371.76,3035.38,3470.55,1.20466345,1.307951801,1.247783588,0.764490241,0.688221697,0.786889223,"plasma membrane","K20279","SYNJ; synaptojanin [EC:3.1.3.36]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0005975 carbohydrate metabolic process; GO:0006066 alcohol metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016311 dephosphorylation; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0030258 lipid modification; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process; GO:0043647 inositol phosphate metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0046164 alcohol catabolic process; GO:0046174 polyol catabolic process; GO:0046434 organophosphate catabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046838 phosphorylated carbohydrate dephosphorylation; GO:0046839 phospholipid dephosphorylation; GO:0046855 inositol phosphate dephosphorylation; GO:0046856 phosphatidylinositol dephosphorylation; GO:0048311 mitochondrion distribution; GO:0048312 intracellular distribution of mitochondria; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0051179 localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0060322 head development; GO:0061024 membrane organization; GO:0071545 inositol phosphate catabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090407 organophosphate biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901616 organic hydroxy compound catabolic process;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005881 cytoplasmic microtubule; GO:0005886 plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0019867 outer membrane; GO:0019898 extrinsic component of membrane; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031312 extrinsic component of organelle membrane; GO:0031315 extrinsic component of mitochondrial outer membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0032587 ruffle membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045121 membrane raft; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0098857 membrane microdomain; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0004438 phosphatidylinositol-3-phosphatase activity; GO:0004439 phosphatidylinositol-4","5-bisphosphate 5-phosphatase activity; GO:0004445 inositol-polyphosphate 5-phosphatase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding; GO:0030165 PDZ domain binding; GO:0034593 phosphatidylinositol bisphosphate phosphatase activity; GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity; GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0043813 phosphatidylinositol-3","5-bisphosphate 5-phosphatase activity; GO:0046030 inositol trisphosphate phosphatase activity; GO:0052629 phosphatidylinositol-3","5-bisphosphate 3-phosphatase activity; GO:0052744 phosphatidylinositol monophosphate phosphatase activity; GO:0052745 inositol phosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity; GO:0106018 phosphatidylinositol-3","5-bisphosphate phosphatase activity; GO:0106019 phosphatidylinositol-4","5-bisphosphate phosphatase activity;","PF03372; PF08952","PF03372 Endonuclease/Exonuclease/phosphatase family; PF08952 Domain of unknown function (DUF1866) ","U","KOG0566","Inositol-1",4,"5-triphosphate 5-phosphatase (synaptojanin)"," INP51/INP52/INP53 family",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-199991 Membrane Trafficking;R-HSA-556833 Metabolism of lipids;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828","UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["O15060","Zinc finger and BTB domain-containing protein 39 OS=Homo sapiens OX=9606 GN=ZBTB39 PE=1 SV=1","ZBTB39",1.478083686,0.165877465,"nochange",2335.25,2149.36,2481.89,4286.58,2204.89,3805.6,0.811622393,0.747015826,0.862587518,1.489812362,0.766315426,1.322646475,"nucleus","K10511",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;",null,"GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00651; PF00096","PF00651 BTB/POZ domain; PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger"]
["O15067","Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4","PFAS",0.831515991,{"v":4.82066E-5,"d":"4.82E-05"},"down",158019,155589,160069,132503,130014,131353,1.092867591,1.076061585,1.107045497,0.916397613,0.89918356,0.908444153,"nucleus","K01952","PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]","hsa00230 Purine metabolism; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006188 IMP biosynthetic process; GO:0006189 'de novo' IMP biosynthetic process; GO:0006520 cellular amino acid metabolic process; GO:0006541 glutamine metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009064 glutamine family amino acid metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046040 IMP metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048856 anatomical structure development; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060322 head development; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:0097065 anterior head development; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004642 phosphoribosylformylglycinamidine synthase activity; GO:0016874 ligase activity; GO:0016879 ligase activity"," forming carbon-nitrogen bonds; GO:0016884 carbon-nitrogen ligase activity"," with glutamine as amido-N-donor;","PF18076; PF18072; PF02769; PF13507","PF18076 Formylglycinamide ribonucleotide amidotransferase N-terminal; PF18072 Formylglycinamide ribonucleotide amidotransferase linker domain; PF02769 AIR synthase related protein"," C-terminal domain; PF13507 CobB/CobQ-like glutamine amidotransferase domain","F","KOG1907","Phosphoribosylformylglycinamidine synthase","WP4224 PURINE METABOLISM AND RELATED DISORDERS","http://www.wikipathways.org/instance/WP4224_r120400",null,"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis;R-HSA-8956320 Nucleotide biosynthesis","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-73817;https://reactome.org/PathwayBrowser/#/R-HSA-8956320"]
["O15084","Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5","ANKRD28",0.842957992,0.040860781,"nochange",11887.8,12057.3,11865,9832.6,11186.7,9167.11,1.080766241,1.096176146,1.078693404,0.893919997,1.017026506,0.833417706,"cytoplasm","K15502",null,null,"GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006996 organelle organization; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0022607 cellular component assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0071840 cellular component organization or biogenesis; GO:0090114 COPII-coated vesicle budding;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",{"$nulls":3},"R","KOG0504","FOG: Ankyrin repeat",{"$nulls":3},"R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-171319 Telomere Extension By Telomerase;R-HSA-180786 Extension of Telomeres;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-73886 Chromosome Maintenance;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-157579;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-171319;https://reactome.org/PathwayBrowser/#/R-HSA-180786;https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73886;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["O15085","Rho guanine nucleotide exchange factor 11 OS=Homo sapiens OX=9606 GN=ARHGEF11 PE=1 SV=1","ARHGEF11",1.004483063,0.911572098,"nochange",2097.46,2724.72,1732.49,"NA",2292.14,2097.23,0.958265869,1.244841941,0.791522144,"NA",1.047209257,0.958160789,"nucleus","K12331","ARHGEF11; Rho guanine nucleotide exchange factor 11","hsa04270 Vascular smooth muscle contraction; hsa05130 Pathogenic Escherichia coli infection; hsa04928 Parathyroid hormone synthesis"," secretion and action; hsa05200 Pathways in cancer; hsa05163 Human cytomegalovirus infection","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001505 regulation of neurotransmitter levels; GO:0001558 regulation of cell growth; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001703 gastrulation with mouth forming first; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002165 instar larval or pupal development; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003012 muscle system process; GO:0003381 epithelial cell morphogenesis involved in gastrulation; GO:0003382 epithelial cell morphogenesis; GO:0003383 apical constriction; GO:0003384 apical constriction involved in gastrulation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006928 movement of cell or subcellular component; GO:0006936 muscle contraction; GO:0006941 striated muscle contraction; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007266 Rho protein signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007277 pole cell development; GO:0007349 cellularization; GO:0007369 gastrulation; GO:0007370 ventral furrow formation; GO:0007374 posterior midgut invagination; GO:0007375 anterior midgut invagination; GO:0007377 germ-band extension; GO:0007399 nervous system development; GO:0007424 open tracheal system development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008360 regulation of cell shape; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009826 unidimensional cell growth; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010004 gastrulation involving germ band extension; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016331 morphogenesis of embryonic epithelium; GO:0016476 regulation of embryonic cell shape; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030048 actin filament-based movement; GO:0030154 cell differentiation; GO:0030588 pseudocleavage; GO:0030589 pseudocleavage involved in syncytial blastoderm formation; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031532 actin cytoskeleton reorganization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0035023 regulation of Rho protein signal transduction; GO:0035025 positive regulation of Rho protein signal transduction; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035277 spiracle morphogenesis"," open tracheal system; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0040007 growth; GO:0040008 regulation of growth; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043519 regulation of myosin II filament organization; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045995 regulation of embryonic development; GO:0046578 regulation of Ras protein signal transduction; GO:0046579 positive regulation of Ras protein signal transduction; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051057 positive regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051493 regulation of cytoskeleton organization; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0060571 morphogenesis of an epithelial fold; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070252 actin-mediated cell contraction; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090254 cell elongation involved in imaginal disc-derived wing morphogenesis; GO:0097435 supramolecular fiber organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005826 actomyosin contractile ring; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0016328 lateral plasma membrane; GO:0030478 actin cap; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0032153 cell division site; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045177 apical part of cell; GO:0045178 basal part of cell; GO:0045179 apical cortex; GO:0070938 contractile ring; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region;","GO:0001664 G protein-coupled receptor binding; GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0098772 molecular function regulator;","PF00595; PF09128; PF00621; PF17838","PF00595 PDZ domain; PF09128 Regulator of G protein signalling-like domain; PF00621 RhoGEF domain; PF17838 PH domain","T","KOG3520","Predicted guanine nucleotide exchange factor",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-193648 NRAGE signals death through JNK;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-194315 Signaling by Rho GTPases;R-HSA-204998 Cell death signalling via NRAGE"," NRIF and NADE;R-HSA-372790 Signaling by GPCR;R-HSA-373755 Semaphorin interactions;R-HSA-388396 GPCR downstream signalling;R-HSA-400685 Sema4D in semaphorin signaling;R-HSA-416482 G alpha (12/13) signalling events;R-HSA-416572 Sema4D induced cell migration and growth-cone collapse;R-HSA-422475 Axon guidance;R-HSA-73887 Death Receptor Signalling;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-193648;https://reactome.org/PathwayBrowser/#/R-HSA-193704;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-204998;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-373755;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-400685;https://reactome.org/PathwayBrowser/#/R-HSA-416482;https://reactome.org/PathwayBrowser/#/R-HSA-416572;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-73887;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O15091","Mitochondrial ribonuclease P catalytic subunit OS=Homo sapiens OX=9606 GN=PRORP PE=1 SV=2","PRORP",1.202596648,0.717944885,"nochange",1773.25,1838.44,2035.59,3584.14,1471.14,1736.12,0.855356035,0.886801493,0.981900009,1.728868337,0.709628353,0.837445774,"cytoplasm","K17655",null,null,"GO:0000959 mitochondrial RNA metabolic process; GO:0000963 mitochondrial RNA processing; GO:0000964 mitochondrial RNA 5'-end processing; GO:0000966 RNA 5'-end processing; GO:0001682 tRNA 5'-leader removal; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0034470 ncRNA processing; GO:0034471 ncRNA 5'-end processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090502 RNA phosphodiester bond hydrolysis"," endonucleolytic; GO:0090646 mitochondrial tRNA processing; GO:0097745 mitochondrial tRNA 5'-end processing; GO:0099116 tRNA 5'-end processing; GO:0140053 mitochondrial gene expression; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0009295 nucleoid; GO:0030677 ribonuclease P complex; GO:0030678 mitochondrial ribonuclease P complex; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0042645 mitochondrial nucleoid; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1902494 catalytic complex; GO:1902555 endoribonuclease complex; GO:1905348 endonuclease complex; GO:1990904 ribonucleoprotein complex;","GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0004521 endoribonuclease activity; GO:0004526 ribonuclease P activity; GO:0004540 ribonuclease activity; GO:0004549 tRNA-specific ribonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016891 endoribonuclease activity"," producing 5'-phosphomonoesters; GO:0016893 endonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF16953","PF16953 Protein-only RNase P",{"$nulls":6},"R-HSA-6785470 tRNA processing in the mitochondrion;R-HSA-6787450 tRNA modification in the mitochondrion;R-HSA-72306 tRNA processing;R-HSA-72312 rRNA processing;R-HSA-8868766 rRNA processing in the mitochondrion;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6785470;https://reactome.org/PathwayBrowser/#/R-HSA-6787450;https://reactome.org/PathwayBrowser/#/R-HSA-72306;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868766;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Homo sapiens OX=9606 GN=CHUK PE=1 SV=2","CHUK",0.873565756,0.052362902,"nochange",8014.87,7762.35,8723.5,7334.82,7424.09,6644.08,1.047610749,1.014604266,1.140234635,0.958722508,0.970390846,0.868436996,"cytoplasm","K04467","IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]","hsa05120 Epithelial cell signaling in Helicobacter pylori infection; hsa05160 Hepatitis C; hsa04014 Ras signaling pathway; hsa04622 RIG-I-like receptor signaling pathway; hsa05166 Human T-cell leukemia virus 1 infection; hsa05200 Pathways in cancer; hsa01523 Antifolate resistance; hsa04621 NOD-like receptor signaling pathway; hsa04210 Apoptosis; hsa04660 T cell receptor signaling pathway; hsa05215 Prostate cancer; hsa04936 Alcoholic liver disease; hsa04662 B cell receptor signaling pathway; hsa05162 Measles; hsa04668 TNF signaling pathway; hsa05222 Small cell lung cancer; hsa04659 Th17 cell differentiation; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04920 Adipocytokine signaling pathway; hsa04068 FoxO signaling pathway; hsa05417 Lipid and atherosclerosis; hsa04380 Osteoclast differentiation; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05170 Human immunodeficiency virus 1 infection; hsa05161 Hepatitis B; hsa05221 Acute myeloid leukemia; hsa05169 Epstein-Barr virus infection; hsa05010 Alzheimer disease; hsa05131 Shigellosis; hsa05418 Fluid shear stress and atherosclerosis; hsa05132 Salmonella infection; hsa05165 Human papillomavirus infection; hsa05168 Herpes simplex virus 1 infection; hsa05145 Toxoplasmosis; hsa04623 Cytosolic DNA-sensing pathway; hsa04625 C-type lectin receptor signaling pathway; hsa04010 MAPK signaling pathway; hsa05171 Coronavirus disease - COVID-19; hsa05135 Yersinia infection; hsa04062 Chemokine signaling pathway; hsa04150 mTOR signaling pathway; hsa04658 Th1 and Th2 cell differentiation; hsa05142 Chagas disease; hsa05164 Influenza A; hsa05212 Pancreatic cancer; hsa05163 Human cytomegalovirus infection; hsa05220 Chronic myeloid leukemia; hsa04620 Toll-like receptor signaling pathway; hsa05130 Pathogenic Escherichia coli infection; hsa04657 IL-17 signaling pathway; hsa04064 NF-kappa B signaling pathway; hsa04151 PI3K-Akt signaling pathway; hsa05167 Kaposi sarcoma-associated herpesvirus infection","GO:0000165 MAPK cascade; GO:0000302 response to reactive oxygen species; GO:0001666 response to hypoxia; GO:0001702 gastrulation with mouth forming second; GO:0001756 somitogenesis; GO:0001757 somite specification; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0002009 morphogenesis of an epithelium; GO:0002011 morphogenesis of an epithelial sheet; GO:0002218 activation of innate immune response; GO:0002220 innate immune response activating cell surface receptor signaling pathway; GO:0002221 pattern recognition receptor signaling pathway; GO:0002223 stimulatory C-type lectin receptor signaling pathway; GO:0002224 toll-like receptor signaling pathway; GO:0002225 positive regulation of antimicrobial peptide production; GO:0002230 positive regulation of defense response to virus by host; GO:0002237 response to molecule of bacterial origin; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002474 antigen processing and presentation of peptide antigen via MHC class I; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I"," TAP-dependent; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002702 positive regulation of production of molecular mediator of immune response; GO:0002756 MyD88-independent toll-like receptor signaling pathway; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002759 regulation of antimicrobial humoral response; GO:0002760 positive regulation of antimicrobial humoral response; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0002784 regulation of antimicrobial peptide production; GO:0002786 regulation of antibacterial peptide production; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0002803 positive regulation of antibacterial peptide production; GO:0002805 regulation of antimicrobial peptide biosynthetic process; GO:0002807 positive regulation of antimicrobial peptide biosynthetic process; GO:0002808 regulation of antibacterial peptide biosynthetic process; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0002920 regulation of humoral immune response; GO:0002922 positive regulation of humoral immune response; GO:0003002 regionalization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0006963 positive regulation of antibacterial peptide biosynthetic process; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007249 I-kappaB kinase/NF-kappaB signaling; GO:0007252 I-kappaB phosphorylation; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007266 Rho protein signal transduction; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007379 segment specification; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007589 body fluid secretion; GO:0007595 lactation; GO:0008063 Toll signaling pathway; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009612 response to mechanical stimulus; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019730 antimicrobial humoral response; GO:0019731 antibacterial humoral response; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030316 osteoclast differentiation; GO:0030856 regulation of epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0030879 mammary gland development; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032515 negative regulation of phosphoprotein phosphatase activity; GO:0032647 regulation of interferon-alpha production; GO:0032727 positive regulation of interferon-alpha production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033209 tumor necrosis factor-mediated signaling pathway; GO:0033554 cellular response to stress; GO:0033598 mammary gland epithelial cell proliferation; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034599 cellular response to oxidative stress; GO:0034612 response to tumor necrosis factor; GO:0034613 cellular protein localization; GO:0034614 cellular response to reactive oxygen species; GO:0035282 segmentation; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035308 negative regulation of protein dephosphorylation; GO:0035507 regulation of myosin-light-chain-phosphatase activity; GO:0035509 negative regulation of myosin-light-chain-phosphatase activity; GO:0035556 intracellular signal transduction; GO:0035666 TRIF-dependent toll-like receptor signaling pathway; GO:0035994 response to muscle stretch; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0038061 NIK/NF-kappaB signaling; GO:0038093 Fc receptor signaling pathway; GO:0038095 Fc-epsilon receptor signaling pathway; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042475 odontogenesis of dentin-containing tooth; GO:0042476 odontogenesis; GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I; GO:0042692 muscle cell differentiation; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045595 regulation of cell differentiation; GO:0045601 regulation of endothelial cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046686 response to cadmium ion; GO:0046903 secretion; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050673 epithelial cell proliferation; GO:0050688 regulation of defense response to virus; GO:0050691 regulation of defense response to virus by host; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050829 defense response to Gram-negative bacterium; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051403 stress-activated MAPK cascade; GO:0051607 defense response to virus; GO:0051641 cellular localization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0055113 epiboly involved in gastrulation with mouth forming second; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060749 mammary gland alveolus development; GO:0060759 regulation of response to cytokine stimulus; GO:0061053 somite development; GO:0061057 peptidoglycan recognition protein signaling pathway; GO:0061061 muscle structure development; GO:0061180 mammary gland epithelium development; GO:0061377 mammary gland lobule development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070482 response to oxygen levels; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070555 response to interleukin-1; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071276 cellular response to cadmium ion; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071356 cellular response to tumor necrosis factor; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:0090504 epiboly; GO:0098542 defense response to other organism; GO:0098586 cellular response to virus; GO:1900424 regulation of defense response to bacterium; GO:1900426 positive regulation of defense response to bacterium; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901223 negative regulation of NIK/NF-kappaB signaling; GO:1901550 regulation of endothelial cell development; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901888 regulation of cell junction assembly; GO:1901889 negative regulation of cell junction assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903140 regulation of establishment of endothelial barrier; GO:1903347 negative regulation of bicellular tight junction assembly; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904951 positive regulation of establishment of protein localization; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000810 regulation of bicellular tight junction assembly; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0008385 IkappaB kinase complex; GO:0009898 cytoplasmic side of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035631 CD40 receptor complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043235 receptor complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008384 IkappaB kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097110 scaffold protein binding; GO:0140096 catalytic activity"," acting on a protein;","PF00069; PF18397; PF12179","PF00069 Protein kinase domain; PF18397 IQBAL scaffold dimerization domain; PF12179 I-kappa-kinase-beta NEMO binding domain","T","KOG4250","TANK binding protein kinase TBK1","WP2324 AGERAGE PATHWAY;WP4480 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT;WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP5113 ANTIVIRAL AND ANTIINFLAMMATORY EFFECTS OF NRF2 ON SARSCOV2 PATHWAY;WP254 APOPTOSIS;WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP3845 CANONICAL AND NONCANONICAL NOTCH SIGNALING;WP4562 CANONICAL NFKB PATHWAY;WP2795 CARDIAC HYPERTROPHIC RESPONSE;WP3929 CHEMOKINE SIGNALING PATHWAY;WP4655 CYTOSOLIC DNASENSING PATHWAY;WP262 EBSTEINBARR VIRUS LMP1 SIGNALING;WP712 ESTROGEN SIGNALING PATHWAY;WP4136 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP4666 HEPATITIS B INFECTION;WP4880 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION;WP4754 IL18 SIGNALING PATHWAY;WP195 IL1 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP2637 INTERLEUKIN1 IL1 STRUCTURAL PATHWAY;WP2034 LEPTIN SIGNALING PATHWAY;WP2817 MAMMARY GLAND DEVELOPMENT PATHWAY PREGNANCY AND LACTATION STAGE 3 OF 4;WP3849 MAPK AND NFKB SIGNALING PATHWAYS INHIBITED BY YERSINIA YOPJ;WP382 MAPK SIGNALING PATHWAY;WP4630 MEASLES VIRUS INFECTION;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP4329 MIRNAS INVOLVEMENT IN THE IMMUNE RESPONSE IN SEPSIS;WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION;WP4919 NEUROINFLAMMATION;WP288 NODLIKE RECEPTOR NLR SIGNALING PATHWAY;WP3865 NOVEL INTRACELLULAR COMPONENTS OF RIGILIKE RECEPTOR RLR PATHWAY;WP1433 NUCLEOTIDEBINDING OLIGOMERIZATION DOMAIN NOD PATHWAY;WP1434 OSTEOPONTIN SIGNALING;WP4263 PANCREATIC ADENOCARCINOMA PATHWAY;WP2526 PDGF PATHWAY;WP3617 PHOTODYNAMIC THERAPYINDUCED NFKB SURVIVAL SIGNALING;WP4172 PI3KAKT SIGNALING PATHWAY;WP3303 RAC1PAK1P38MMP2 PATHWAY;WP2018 RANKLRANK SIGNALING PATHWAY;WP4223 RAS SIGNALING;WP4481 RESISTIN AS A REGULATOR OF INFLAMMATION;WP4496 SIGNAL TRANSDUCTION THROUGH IL1R;WP4658 SMALL CELL LUNG CANCER;WP4961 STING PATHWAY IN KAWASAKILIKE DISEASE AND COVID19;WP4479 SUPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD;WP5098 TCELL ACTIVATION SARSCOV2;WP3863 TCELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY;WP3851 TLR4 SIGNALING AND TOLERANCE;WP231 TNFALPHA SIGNALING PATHWAY;WP2036 TNFRELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING PATHWAY;WP75 TOLLLIKE RECEPTOR SIGNALING PATHWAY;WP3858 TOLLLIKE RECEPTOR SIGNALING RELATED TO MYD88;WP4482 VITAMIN D IN INFLAMMATORY DISEASES",null,null,"R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168638 NOD1/2 Signaling Pathway;R-HSA-168643 Nucleotide-binding domain"," leucine rich repeat containing receptor (NLR) signaling pathways;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-168927 TICAM1"," RIP1-mediated IKK complex recruitment;R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta;R-HSA-1810476 RIP-mediated NFkB activation via ZBP1;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-198323 AKT phosphorylates targets in the cytosol;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation  ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-448424 Interleukin-17 signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450294 MAP kinase activation;R-HSA-5260271 Diseases of Immune System;R-HSA-5357905 Regulation of TNFR1 signaling;R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway;R-HSA-5602358 Diseases associated with the TLR signaling cascade;R-HSA-5602636 IKBKB deficiency causes SCID;R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR);R-HSA-5603029 IkBA variant leads to EDA-ID;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation;R-HSA-73887 Death Receptor Signalling;R-HSA-75893 TNF signaling;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9020702 Interleukin-1 signaling;R-HSA-933542 TRAF6 mediated NF-kB activation;R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10;R-HSA-937039 IRAK1 recruits IKK complex;R-HSA-937041 IKK complex recruitment mediated by RIP1;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-9758274 Regulation of NF-kappa B signaling;R-HSA-975871 MyD88 cascade initiated on plasma membrane;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"ADIPOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS"]
["O15116","U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1","LSM1",1.39228092,0.004984284,"up",7033.18,7573.66,8304.7,11319.2,10046.5,10533.6,0.76990391,0.829068848,0.909093895,1.239083364,1.099764207,1.153085776,"cytoplasm","K12620","LSM1; U6 snRNA-associated Sm-like protein LSm1","hsa03018 RNA degradation","GO:0000288 nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA; GO:0000291 nuclear-transcribed mRNA catabolic process"," exonucleolytic; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008334 histone mRNA metabolic process; GO:0008380 RNA splicing; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010721 negative regulation of cell development; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019827 stem cell population maintenance; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033962 P-body assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0043170 macromolecule metabolic process; GO:0043928 exonucleolytic catabolism of deadenylated mRNA; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070925 organelle assembly; GO:0071044 histone mRNA catabolic process; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:2000026 regulation of multicellular organismal development;","GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005845 mRNA cap binding complex; GO:0030424 axon; GO:0030425 dendrite; GO:0032991 protein-containing complex; GO:0034518 RNA cap binding complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection; GO:0120114 Sm-like protein family complex; GO:1990124 messenger ribonucleoprotein complex; GO:1990726 Lsm1-7-Pat1 complex; GO:1990904 ribonucleoprotein complex;","GO:0000339 RNA cap binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0036002 pre-mRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF01423","PF01423 LSM domain ","A","KOG1782","Small Nuclear ribonucleoprotein splicing factor",{"$nulls":3},"R-HSA-429914 Deadenylation-dependent mRNA decay;R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-429914;https://reactome.org/PathwayBrowser/#/R-HSA-430039;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["O15117","FYN-binding protein 1 OS=Homo sapiens OX=9606 GN=FYB1 PE=1 SV=2","FYB1",0.940983732,0.366242934,"nochange",8464.28,7967.89,7138.28,7192.88,7143.6,7842.93,1.110072905,1.044972378,0.936170734,0.943331411,0.936868441,1.028584131,"nucleus","K17698","FYB; FYN binding protein","hsa04015 Rap1 signaling pathway; hsa05135 Yersinia infection","GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016310 phosphorylation; GO:0017038 protein import; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050896 response to stimulus; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:1901564 organonitrogen compound metabolic process; GO:1990778 protein localization to cell periphery;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0044877 protein-containing complex binding;","PF07653; PF14603","PF07653 Variant SH3 domain; PF14603 Helically-extended SH3 domain",{"$nulls":3},"WP4542 LEUKOCYTEINTRINSIC HIPPO PATHWAY FUNCTIONS;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4542_r120673;http://www.wikipathways.org/instance/WP69_r120700",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-1500931 Cell-Cell communication;R-HSA-168256 Immune System;R-HSA-202403 TCR signaling;R-HSA-202433 Generation of second messenger molecules;R-HSA-391160 Signal regulatory protein family interactions","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1500931;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-202403;https://reactome.org/PathwayBrowser/#/R-HSA-202433;https://reactome.org/PathwayBrowser/#/R-HSA-391160","ALLOGRAFT REJECTION;APICAL JUNCTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION"]
["O15120","1-acyl-sn-glycerol-3-phosphate acyltransferase beta OS=Homo sapiens OX=9606 GN=AGPAT2 PE=1 SV=1","AGPAT2",0.951122406,0.532614011,"nochange",22877.4,23818.1,21849.2,21480.5,24769.6,18944.3,1.026359531,1.068562597,0.980230912,0.963689751,1.111250188,0.84990702,"extracellular","K13509","AGPAT1_2; lysophosphatidate acyltransferase [EC:2.3.1.51]","hsa04072 Phospholipase D signaling pathway; hsa00561 Glycerolipid metabolism; hsa04975 Fat digestion and absorption; hsa00564 Glycerophospholipid metabolism; hsa01100 Metabolic pathways","GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001961 positive regulation of cytokine-mediated signaling pathway; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006654 phosphatidic acid biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0032940 secretion by cell; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046473 phosphatidic acid metabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0060759 regulation of response to cytokine stimulus; GO:0060760 positive regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0035579 specific granule membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098827 endoplasmic reticulum subcompartment; GO:0099503 secretory vesicle;","GO:0003824 catalytic activity; GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity; GO:0008374 O-acyltransferase activity; GO:0016411 acylglycerol O-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0042171 lysophosphatidic acid acyltransferase activity; GO:0071617 lysophospholipid acyltransferase activity;",null,null,"I","KOG2848","1-acyl-sn-glycerol-3-phosphate acyltransferase","WP236 ADIPOGENESIS;WP4352 CILIARY LANDSCAPE;WP5101 CONGENITAL GENERALIZED LIPODYSTROPHY CGL;WP325 TRIACYLGLYCERIDE SYNTHESIS","http://www.wikipathways.org/instance/WP236_r105873;http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP5101_r119172;http://www.wikipathways.org/instance/WP325_r116669",null,"R-HSA-1430728 Metabolism;R-HSA-1483166 Synthesis of PA;R-HSA-1483206 Glycerophospholipid biosynthesis;R-HSA-1483257 Phospholipid metabolism;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-556833 Metabolism of lipids;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483166;https://reactome.org/PathwayBrowser/#/R-HSA-1483206;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O15126","Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2","SCAMP1",1.511663002,1.443787E-3,"up",3126.81,2834.34,2871.91,4774,4461.95,4116.66,0.845629634,0.766532631,0.776693244,1.291103672,1.206711359,1.11332946,"plasma membrane","K19995",null,null,"GO:0001505 regulation of neurotransmitter levels; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003008 system process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006897 endocytosis; GO:0006955 immune response; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007274 neuromuscular synaptic transmission; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008104 protein localization; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0023052 signaling; GO:0023061 signal release; GO:0032501 multicellular organismal process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042886 amide transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048489 synaptic vesicle transport; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005886 plasma membrane; GO:0008021 synaptic vesicle; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030141 secretory granule; GO:0030424 axon; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0030672 synaptic vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0035579 specific granule membrane; GO:0042581 specific granule; GO:0042588 zymogen granule; GO:0042589 zymogen granule membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0055037 recycling endosome; GO:0055038 recycling endosome membrane; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding;",null,null,"U","KOG3088","Secretory carrier membrane protein",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695","PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O15127","Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2","SCAMP2",1.17986382,0.02171721,"nochange",22807.2,23347.2,21168.2,25563.4,25550,28318.1,0.932465941,0.954543689,0.865455888,1.045152401,1.044604546,1.157777534,"plasma membrane","K19995",null,null,"GO:0001505 regulation of neurotransmitter levels; GO:0003008 system process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007274 neuromuscular synaptic transmission; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008104 protein localization; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0023052 signaling; GO:0023061 signal release; GO:0032501 multicellular organismal process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0042886 amide transport; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048489 synaptic vesicle transport; GO:0050877 nervous system process; GO:0050890 cognition; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0008021 synaptic vesicle; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0055037 recycling endosome; GO:0055038 recycling endosome membrane; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;",{"$nulls":3},"U","KOG3088","Secretory carrier membrane protein","WP727 MONOAMINE TRANSPORT;WP1455 SEROTONIN TRANSPORTER ACTIVITY","http://www.wikipathways.org/instance/WP727_r116775;http://www.wikipathways.org/instance/WP1455_r117827"]
["O15131","Importin subunit alpha-6 OS=Homo sapiens OX=9606 GN=KPNA5 PE=1 SV=3","KPNA5",1.675356326,0.335194533,"nochange",588.613,726.063,523.601,442.669,1319.37,1317.73,0.718105931,0.88579448,0.638791504,0.540054729,1.609627075,1.607626281,"cytoplasm","nucleus","K15042","KPNA5_6; importin subunit alpha-6/7","hsa03013 Nucleocytoplasmic transport; hsa05164 Influenza A; hsa05207 Chemical carcinogenesis - receptor activation","GO:0000003 reproduction; GO:0000018 regulation of DNA recombination; GO:0000737 DNA catabolic process"," endonucleolytic; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006308 DNA catabolic process; GO:0006309 apoptotic DNA fragmentation; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006915 apoptotic process; GO:0006921 cellular component disassembly involved in execution phase of apoptosis; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0019048 modulation by virus of host process; GO:0019054 modulation by virus of host cellular process; GO:0019058 viral life cycle; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019953 sexual reproduction; GO:0022411 cellular component disassembly; GO:0022414 reproductive process; GO:0030262 apoptotic nuclear changes; GO:0031323 regulation of cellular metabolic process; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035821 modulation of process of another organism; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044003 modulation by symbiont of host process; GO:0044068 modulation by symbiont of host cellular process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046794 transport of virus; GO:0046907 intracellular transport; GO:0048232 male gamete generation; GO:0048609 multicellular organismal reproductive process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051701 biological process involved in interaction with host; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0075733 intracellular transport of virus; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0097194 execution phase of apoptosis; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030425 dendrite; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection;","GO:0005048 signal sequence binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008139 nuclear localization sequence binding; GO:0033218 amide binding; GO:0042277 peptide binding;",null,null,"U","KOG0166","Karyopherin (importin) alpha",{"$nulls":3},"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168276 NS1 Mediated Effects on Host Pathways;R-HSA-5663205 Infectious disease;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1169408;https://reactome.org/PathwayBrowser/#/R-HSA-1169410;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168276;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-913531"]
["O15143","Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3","ARPC1B",1.044703581,0.378398859,"nochange",54441,50221.8,48709.7,51242.4,56520.6,52465.8,1.041596447,0.960872292,0.931941928,0.980398997,1.081384548,1.003805788,"cytoplasm","K05757","ARPC1A_B; actin related protein 2/3 complex"," subunit 1A/1B","hsa04666 Fc gamma R-mediated phagocytosis; hsa04530 Tight junction; hsa05131 Shigellosis; hsa05100 Bacterial invasion of epithelial cells; hsa05132 Salmonella infection; hsa04810 Regulation of actin cytoskeleton; hsa05130 Pathogenic Escherichia coli infection; hsa04144 Endocytosis; hsa05135 Yersinia infection","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001745 compound eye morphogenesis; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007413 axonal fasciculation; GO:0007423 sensory organ development; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008407 chaeta morphogenesis; GO:0008593 regulation of Notch signaling pathway; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0014070 response to organic cyclic compound; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022416 chaeta development; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030037 actin filament reorganization involved in cell cycle; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030588 pseudocleavage; GO:0030589 pseudocleavage involved in syncytial blastoderm formation; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031175 neuron projection development; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031532 actin cytoskeleton reorganization; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032355 response to estradiol; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033627 cell adhesion mediated by integrin; GO:0033993 response to lipid; GO:0034314 Arp2/3 complex-mediated actin nucleation; GO:0034613 cellular protein localization; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043254 regulation of protein-containing complex assembly; GO:0043627 response to estrogen; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045010 actin nucleation; GO:0045184 establishment of protein localization; GO:0045747 positive regulation of Notch signaling pathway; GO:0046907 intracellular transport; GO:0048013 ephrin receptor signaling pathway; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060491 regulation of cell projection assembly; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090527 actin filament reorganization; GO:0090596 sensory organ morphogenesis; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:0106030 neuron projection fasciculation; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901700 response to oxygen-containing compound; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005885 Arp2/3 protein complex; GO:0015629 actin cytoskeleton; GO:0032991 protein-containing complex; GO:0036284 tubulobulbar complex; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;",null,null,"Z","KOG1523","Actin-related protein Arp2/3 complex"," subunit ARPC1/p41-ARC","WP3937 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY;WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION","http://www.wikipathways.org/instance/WP3937_r120792;http://www.wikipathways.org/instance/WP2272_r118427",null,"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-3928662 EPHB-mediated forward signaling;R-HSA-422475 Axon guidance;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-3928662;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663213;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O15144","Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1","ARPC2",1.119288946,0.02995257,"nochange",178995,174296,194572,203304,201745,208168,0.924975023,0.900692459,1.005470769,1.050594274,1.042537982,1.075729493,"cytoplasm","K05758","ARPC2; actin related protein 2/3 complex"," subunit 2","hsa04666 Fc gamma R-mediated phagocytosis; hsa04530 Tight junction; hsa05131 Shigellosis; hsa05100 Bacterial invasion of epithelial cells; hsa05132 Salmonella infection; hsa04810 Regulation of actin cytoskeleton; hsa05130 Pathogenic Escherichia coli infection; hsa04144 Endocytosis; hsa05135 Yersinia infection","GO:0000302 response to reactive oxygen species; GO:0000902 cell morphogenesis; GO:0001667 ameboidal-type cell migration; GO:0002009 morphogenesis of an epithelium; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008360 regulation of cell shape; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010243 response to organonitrogen compound; GO:0010591 regulation of lamellipodium assembly; GO:0010592 positive regulation of lamellipodium assembly; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0014070 response to organic cyclic compound; GO:0014910 regulation of smooth muscle cell migration; GO:0014911 positive regulation of smooth muscle cell migration; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030834 regulation of actin filament depolymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033554 cellular response to stress; GO:0034021 response to silicon dioxide; GO:0034314 Arp2/3 complex-mediated actin nucleation; GO:0034599 cellular response to oxidative stress; GO:0034614 cellular response to reactive oxygen species; GO:0035556 intracellular signal transduction; GO:0036119 response to platelet-derived growth factor; GO:0036120 cellular response to platelet-derived growth factor stimulus; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042221 response to chemical; GO:0042542 response to hydrogen peroxide; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045010 actin nucleation; GO:0045472 response to ether; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045785 positive regulation of cell adhesion; GO:0046677 response to antibiotic; GO:0048013 ephrin receptor signaling pathway; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070301 cellular response to hydrogen peroxide; GO:0070358 actin polymerization-dependent cell motility; GO:0070528 protein kinase C signaling; GO:0070848 response to growth factor; GO:0070849 response to epidermal growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071236 cellular response to antibiotic; GO:0071310 cellular response to organic substance; GO:0071362 cellular response to ether; GO:0071363 cellular response to growth factor stimulus; GO:0071364 cellular response to epidermal growth factor stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071801 regulation of podosome assembly; GO:0071803 positive regulation of podosome assembly; GO:0071840 cellular component organization or biogenesis; GO:0072752 cellular response to rapamycin; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090313 regulation of protein targeting to membrane; GO:0090314 positive regulation of protein targeting to membrane; GO:0090316 positive regulation of intracellular protein transport; GO:0097237 cellular response to toxic substance; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097327 response to antineoplastic agent; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900024 regulation of substrate adhesion-dependent cell spreading; GO:1900026 positive regulation of substrate adhesion-dependent cell spreading; GO:1901355 response to rapamycin; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901879 regulation of protein depolymerization; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1902743 regulation of lamellipodium organization; GO:1902745 positive regulation of lamellipodium organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903533 regulation of protein targeting; GO:1903829 positive regulation of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:1990089 response to nerve growth factor; GO:1990090 cellular response to nerve growth factor stimulus; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000249 regulation of actin cytoskeleton reorganization; GO:2000251 positive regulation of actin cytoskeleton reorganization; GO:2000812 regulation of barbed-end actin filament capping; GO:2000814 positive regulation of barbed-end actin filament capping;","GO:0001726 ruffle; GO:0002102 podosome; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005885 Arp2/3 protein complex; GO:0005886 plasma membrane; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030141 secretory granule; GO:0030424 axon; GO:0030425 dendrite; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031941 filamentous actin; GO:0031982 vesicle; GO:0032587 ruffle membrane; GO:0032991 protein-containing complex; GO:0036194 muscle cell projection; GO:0036195 muscle cell projection membrane; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043198 dendritic shaft; GO:0043204 perikaryon; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0044309 neuron spine; GO:0045202 synapse; GO:0061825 podosome core; GO:0061826 podosome ring; GO:0061827 sperm head; GO:0061830 concave side of sperm head; GO:0061834 actin filament branch point; GO:0061835 ventral surface of cell; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0090725 peripheral region of growth cone; GO:0097440 apical dendrite; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003779 actin binding; GO:0005102 signaling receptor binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0035254 glutamate receptor binding; GO:0035650 AP-1 adaptor complex binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding; GO:0051117 ATPase binding; GO:0071933 Arp2/3 complex binding;",null,null,"Z","KOG2826","Actin-related protein Arp2/3 complex"," subunit ARPC2","WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION","http://www.wikipathways.org/instance/WP2272_r118427",null,"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199991 Membrane Trafficking;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-3928662 EPHB-mediated forward signaling;R-HSA-422475 Axon guidance;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-3928662;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663213;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","APICAL JUNCTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION"]
["O15145","Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3","ARPC3",1.150959493,0.015802763,"nochange",106065,111308,117856,131160,130486,124189,0.882570757,0.926197952,0.9806841,1.091387172,1.085778794,1.033381226,"cytoplasm","K05756","ARPC3; actin related protein 2/3 complex"," subunit 3","hsa04666 Fc gamma R-mediated phagocytosis; hsa04530 Tight junction; hsa05131 Shigellosis; hsa05100 Bacterial invasion of epithelial cells; hsa05132 Salmonella infection; hsa04810 Regulation of actin cytoskeleton; hsa05130 Pathogenic Escherichia coli infection; hsa04144 Endocytosis; hsa05135 Yersinia infection","GO:0001667 ameboidal-type cell migration; GO:0002009 morphogenesis of an epithelium; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0034314 Arp2/3 complex-mediated actin nucleation; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0040011 locomotion; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045010 actin nucleation; GO:0048013 ephrin receptor signaling pathway; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060429 epithelium development; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070358 actin polymerization-dependent cell motility; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:0110053 regulation of actin filament organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005885 Arp2/3 protein complex; GO:0015629 actin cytoskeleton; GO:0030027 lamellipodium; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031252 cell leading edge; GO:0031941 filamentous actin; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0061850 growth cone leading edge; GO:0090725 peripheral region of growth cone; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding;",null,null,"Z","KOG3155","Actin-related protein Arp2/3 complex"," subunit ARPC3","WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION","http://www.wikipathways.org/instance/WP2272_r118427",null,"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199991 Membrane Trafficking;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-3928662 EPHB-mediated forward signaling;R-HSA-422475 Axon guidance;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-3928662;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663213;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["O15160","DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1","POLR1C",1.056698522,0.291686902,"nochange",46381.9,48919.7,45846.7,48585.9,46955.9,53609.4,0.958635478,1.011087515,0.947573799,1.004188433,0.970499088,1.108015687,"cytoplasm","K03027","RPAC1; DNA-directed RNA polymerases I and III subunit RPAC1","hsa04623 Cytosolic DNA-sensing pathway; hsa03020 RNA polymerase","GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006353 DNA-templated transcription"," termination; GO:0006360 transcription by RNA polymerase I; GO:0006361 transcription initiation from RNA polymerase I promoter; GO:0006363 termination of RNA polymerase I transcription; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0040029 regulation of gene expression"," epigenetic; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005666 RNA polymerase III complex; GO:0005730 nucleolus; GO:0005736 RNA polymerase I complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0003899 DNA-directed 5'-3' RNA polymerase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0034062 5'-3' RNA polymerase activity; GO:0097747 RNA polymerase activity; GO:0140098 catalytic activity"," acting on RNA;","PF01193; PF01000","PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain; PF01000 RNA polymerase Rpb3/RpoA insert domain","K","KOG1521","RNA polymerase I and III"," subunit RPA40/RPC40","WP4655 CYTOSOLIC DNASENSING PATHWAY;WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP4655_r105163;http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-5250913 Positive epigenetic regulation of rRNA expression;R-HSA-5250924 B-WICH complex positively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-73762 RNA Polymerase I Transcription Initiation;R-HSA-73772 RNA Polymerase I Promoter Escape;R-HSA-73780 RNA Polymerase III Chain Elongation;R-HSA-73854 RNA Polymerase I Promoter Clearance;R-HSA-73863 RNA Polymerase I Transcription Termination;R-HSA-73864 RNA Polymerase I Transcription;R-HSA-73980 RNA Polymerase III Transcription Termination;R-HSA-74158 RNA Polymerase III Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation;R-HSA-76046 RNA Polymerase III Transcription Initiation;R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter;R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter;R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1834949;https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-427413;https://reactome.org/PathwayBrowser/#/R-HSA-5250913;https://reactome.org/PathwayBrowser/#/R-HSA-5250924;https://reactome.org/PathwayBrowser/#/R-HSA-5250941;https://reactome.org/PathwayBrowser/#/R-HSA-73762;https://reactome.org/PathwayBrowser/#/R-HSA-73772;https://reactome.org/PathwayBrowser/#/R-HSA-73780;https://reactome.org/PathwayBrowser/#/R-HSA-73854;https://reactome.org/PathwayBrowser/#/R-HSA-73863;https://reactome.org/PathwayBrowser/#/R-HSA-73864;https://reactome.org/PathwayBrowser/#/R-HSA-73980;https://reactome.org/PathwayBrowser/#/R-HSA-74158;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-749476;https://reactome.org/PathwayBrowser/#/R-HSA-76046;https://reactome.org/PathwayBrowser/#/R-HSA-76061;https://reactome.org/PathwayBrowser/#/R-HSA-76066;https://reactome.org/PathwayBrowser/#/R-HSA-76071","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O15162","Phospholipid scramblase 1 OS=Homo sapiens OX=9606 GN=PLSCR1 PE=1 SV=1","PLSCR1",0.666302515,0.095026911,"nochange",6292.63,4523.34,5093.17,3379.81,4641.86,2578.63,1.424239064,1.023787753,1.152759923,0.764967498,1.050612914,0.583632849,"cytoplasm",{"$nulls":3},"GO:0001775 cell activation; GO:0002237 response to molecule of bacterial origin; GO:0002252 immune effector process; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002526 acute inflammatory response; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006575 cellular modified amino acid metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006658 phosphatidylserine metabolic process; GO:0006659 phosphatidylserine biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006953 acute-phase response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0007009 plasma membrane organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009611 response to wounding; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010876 lipid localization; GO:0010911 regulation of isomerase activity; GO:0010912 positive regulation of isomerase activity; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015914 phospholipid transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0017121 plasma membrane phospholipid scrambling; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030168 platelet activation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0032091 negative regulation of protein binding; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032781 positive regulation of ATP-dependent activity; GO:0033003 regulation of mast cell activation; GO:0033036 macromolecule localization; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035455 response to interferon-alpha; GO:0035456 response to interferon-beta; GO:0035556 intracellular signal transduction; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042398 cellular modified amino acid biosynthetic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043393 regulation of protein binding; GO:0043462 regulation of ATP-dependent activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045017 glycerolipid biosynthetic process; GO:0045069 regulation of viral genome replication; GO:0045071 negative regulation of viral genome replication; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046474 glycerophospholipid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050865 regulation of cell activation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051607 defense response to virus; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070782 phosphatidylserine exposure on apoptotic cell surface; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071396 cellular response to lipid; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097035 regulation of membrane lipid distribution; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097194 execution phase of apoptosis; GO:0097659 nucleic acid-templated transcription; GO:0098542 defense response to other organism; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903900 regulation of viral life cycle; GO:1903901 negative regulation of viral life cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity; GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; GO:2001020 regulation of response to DNA damage stimulus; GO:2001022 positive regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031012 extracellular matrix; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045121 membrane raft; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098857 membrane microdomain;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0005102 signaling receptor binding; GO:0005154 epidermal growth factor receptor binding; GO:0005215 transporter activity; GO:0005319 lipid transporter activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005548 phospholipid transporter activity; GO:0017124 SH3 domain binding; GO:0017128 phospholipid scramblase activity; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0042609 CD4 receptor binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0048306 calcium-dependent protein binding; GO:0070851 growth factor receptor binding; GO:0140110 transcription regulator activity;","PF03803","PF03803 Scramblase ","M","KOG0621","Phospholipid scramblase","WP5090 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY;WP437 EGFEGFR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5090_r118898;http://www.wikipathways.org/instance/WP437_r120689",{"$nulls":3},"CHOLESTEROL HOMEOSTASIS;COMPLEMENT;IL2 STAT5 SIGNALING;INTERFERON ALPHA RESPONSE;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_CHOLESTEROL_HOMEOSTASIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["O15164","Transcription intermediary factor 1-alpha OS=Homo sapiens OX=9606 GN=TRIM24 PE=1 SV=3","TRIM24",1.066004357,0.179326323,"nochange",12042.6,10551.8,11095.8,12237.6,11890.9,11785.4,1.03809402,0.909584349,0.956478139,1.054903375,1.025017204,1.015922913,"nucleus","K08881",null,null,"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007422 peripheral nervous system development; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016310 phosphorylation; GO:0016567 protein ubiquitination; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031647 regulation of protein stability; GO:0032101 regulation of response to external stimulus; GO:0032104 regulation of response to extracellular stimulus; GO:0032107 regulation of response to nutrient levels; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043627 response to estrogen; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046777 protein autophosphorylation; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070562 regulation of vitamin D receptor signaling pathway; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0071391 cellular response to estrogen stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072507 divalent inorganic cation homeostasis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097485 neuron projection guidance; GO:0097659 nucleic acid-templated transcription; GO:0098771 inorganic ion homeostasis; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1902531 regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000791 euchromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005726 perichromatin fibrils; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0002039 p53 binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008270 zinc ion binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016922 nuclear receptor binding; GO:0019787 ubiquitin-like protein transferase activity; GO:0034056 estrogen response element binding; GO:0042393 histone binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051427 hormone receptor binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0070577 lysine-acetylated histone binding; GO:0097159 organic cyclic compound binding; GO:0140030 modification-dependent protein binding; GO:0140033 acetylation-dependent protein binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00643; PF00628; PF00439","PF00643 B-box zinc finger; PF00628 PHD-finger; PF00439 Bromodomain","O","KOG2177","Predicted E3 ubiquitin ligase",null,null,"Transcription factor","R-HSA-1226099 Signaling by FGFR in disease;R-HSA-1643685 Disease;R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants;R-HSA-1839124 FGFR1 mutant receptor activation;R-HSA-5655302 Signaling by FGFR1 in disease;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-6802952 Signaling by BRAF and RAF1 fusions;R-HSA-6802957 Oncogenic MAPK signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1226099;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1839117;https://reactome.org/PathwayBrowser/#/R-HSA-1839124;https://reactome.org/PathwayBrowser/#/R-HSA-5655302;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-6802952;https://reactome.org/PathwayBrowser/#/R-HSA-6802957"]
["O15173","Membrane-associated progesterone receptor component 2 OS=Homo sapiens OX=9606 GN=PGRMC2 PE=1 SV=1","PGRMC2",1.261113765,0.005498857,"up",22691.8,21753.9,22748,26220.4,30064,28454.5,0.896126309,0.859087516,0.898345714,1.035474941,1.1872633,1.123702221,"cytoplasm","K17278","PGRMC1_2; membrane-associated progesterone receptor component","hsa04080 Neuroactive ligand-receptor interaction","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0014070 response to organic cyclic compound; GO:0016192 vesicle-mediated transport; GO:0023052 signaling; GO:0032870 cellular response to hormone stimulus; GO:0032940 secretion by cell; GO:0033993 response to lipid; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043401 steroid hormone mediated signaling pathway; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048545 response to steroid hormone; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005783 endoplasmic reticulum; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030424 axon; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031982 vesicle; GO:0035579 specific granule membrane; GO:0036477 somatodendritic compartment; GO:0042581 specific granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0003707 steroid hormone receptor activity; GO:0005488 binding; GO:0005496 steroid binding; GO:0008289 lipid binding; GO:0020037 heme binding; GO:0032934 sterol binding; GO:0035100 ecdysone binding; GO:0036094 small molecule binding; GO:0038023 signaling receptor activity; GO:0042562 hormone binding; GO:0043178 alcohol binding; GO:0046906 tetrapyrrole binding; GO:0060089 molecular transducer activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00173","PF00173 Cytochrome b5-like Heme/Steroid binding domain","R","KOG1110","Putative steroid membrane receptor Hpr6.6/25-Dx","WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP4352_r102218",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013405 RHOD GTPase cycle;R-HSA-9013408 RHOG GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9013405;https://reactome.org/PathwayBrowser/#/R-HSA-9013408;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O15182","Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2","CETN3",0.848989667,0.517465525,"nochange",2706.86,3432.8,4591.46,3690.57,1988.22,3431.82,0.818535481,1.038054645,1.388425304,1.116002486,0.601223784,1.0377583,"cytoplasm","K16466",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007098 centrosome cycle; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0031023 microtubule organizing center organization; GO:0071840 cellular component organization or biogenesis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005814 centriole; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005929 cilium; GO:0015630 microtubule cytoskeleton; GO:0032391 photoreceptor connecting cilium; GO:0035869 ciliary transition zone; GO:0036064 ciliary basal body; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0097730 non-motile cilium; GO:0097731 9+0 non-motile cilium; GO:0097733 photoreceptor cell cilium; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0031683 G-protein beta/gamma-subunit complex binding; GO:0044877 protein-containing complex binding;","PF13499","PF13499 EF-hand domain pair","ZD","KOG0028","Ca2+-binding protein (centrin/caltractin)"," EF-Hand superfamily protein","WP4262 BREAST CANCER PATHWAY","http://www.wikipathways.org/instance/WP4262_r108103"]
["O15194","CTD small phosphatase-like protein OS=Homo sapiens OX=9606 GN=CTDSPL PE=1 SV=2","CTDSPL",0.704954877,0.054239793,"nochange",2920.98,3415.97,3487.31,1810.24,2739.96,2375.46,1.046326191,1.223636889,1.249191638,0.648447276,0.981482897,0.850915109,"cytoplasm","K15731",null,null,"GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010948 negative regulation of cell cycle process; GO:0016311 dephosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0036211 protein modification process; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045786 negative regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0045936 negative regulation of phosphate metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;",null,"GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004722 protein serine/threonine phosphatase activity; GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"K","KOG1605","TFIIF-interacting CTD phosphatase"," including NLI-interacting factor (involved in RNA polymerase II regulation)"]
["O15212","Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1","PFDN6",1.215157743,0.001181862,"up",58028.2,56483.4,59778.2,69046.1,72987,69756.5,0.901807245,0.877799748,0.929003723,1.073034718,1.134279633,1.084074934,"cytoplasm","K04798",null,null,"GO:0006457 protein folding; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0051131 chaperone-mediated protein complex assembly; GO:0065003 protein-containing complex assembly; GO:0071840 cellular component organization or biogenesis;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016272 prefoldin complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0051082 unfolded protein binding; GO:0051087 chaperone binding;",null,null,"O","KOG3478","Prefoldin subunit 6"," KE2 family","WP4918 CELLULAR PROTEOSTASIS","http://www.wikipathways.org/instance/WP4918_r117679",null,"R-HSA-389957 Prefoldin mediated transfer of substrate  to CCT/TriC;R-HSA-389958 Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding;R-HSA-390466 Chaperonin-mediated protein folding;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins","https://reactome.org/PathwayBrowser/#/R-HSA-389957;https://reactome.org/PathwayBrowser/#/R-HSA-389958;https://reactome.org/PathwayBrowser/#/R-HSA-390466;https://reactome.org/PathwayBrowser/#/R-HSA-391251;https://reactome.org/PathwayBrowser/#/R-HSA-392499"]
["O15226","NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2","NKRF",1.193777382,0.0022197,"up",23428,24985.1,25289,28795.8,29669.8,29518.3,0.869388815,0.927171184,0.938448598,1.068582314,1.101015549,1.095393541,"nucleus",{"$nulls":3},"GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF01424","PF01424 R3H domain","R","KOG1721","FOG: Zn-finger","WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY;WP4884 PATHOGENESIS OF SARSCOV2 MEDIATED BY NSP9NSP10 COMPLEX","http://www.wikipathways.org/instance/WP5115_r120597;http://www.wikipathways.org/instance/WP4884_r120646"]
["O15228","Dihydroxyacetone phosphate acyltransferase OS=Homo sapiens OX=9606 GN=GNPAT PE=1 SV=1","GNPAT",1.098113461,0.044887816,"nochange",35142.3,33967.4,32118,36850.4,35923.3,38385.8,0.992780168,0.959588902,0.907342815,1.041034488,1.014843644,1.084409983,"cytoplasm","K00649","GNPAT; glyceronephosphate O-acyltransferase [EC:2.3.1.42]","hsa04146 Peroxisome; hsa00564 Glycerophospholipid metabolism","GO:0001101 response to acid chemical; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006654 phosphatidic acid biosynthetic process; GO:0006662 glycerol ether metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0007043 cell-cell junction assembly; GO:0007272 ensheathment of neurons; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007584 response to nutrient; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008366 axon ensheathment; GO:0008610 lipid biosynthetic process; GO:0008611 ether lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010927 cellular component assembly involved in morphogenesis; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0018904 ether metabolic process; GO:0019637 organophosphate metabolic process; GO:0021549 cerebellum development; GO:0021575 hindbrain morphogenesis; GO:0021587 cerebellum morphogenesis; GO:0022037 metencephalon development; GO:0022607 cellular component assembly; GO:0030902 hindbrain development; GO:0030913 paranodal junction assembly; GO:0031667 response to nutrient levels; GO:0032288 myelin assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033993 response to lipid; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034613 cellular protein localization; GO:0042221 response to chemical; GO:0042552 myelination; GO:0042594 response to starvation; GO:0042886 amide transport; GO:0043574 peroxisomal transport; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045184 establishment of protein localization; GO:0045216 cell-cell junction organization; GO:0046473 phosphatidic acid metabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046485 ether lipid metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046504 glycerol ether biosynthetic process; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060322 head development; GO:0061024 membrane organization; GO:0070542 response to fatty acid; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0090407 organophosphate biosynthetic process; GO:0097384 cellular lipid biosynthetic process; GO:1901503 ether biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005782 peroxisomal matrix; GO:0005829 cytosol; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031903 microbody membrane; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;","GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008374 O-acyltransferase activity; GO:0016287 glycerone-phosphate O-acyltransferase activity; GO:0016289 CoA hydrolase activity; GO:0016290 palmitoyl-CoA hydrolase activity; GO:0016407 acetyltransferase activity; GO:0016413 O-acetyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016790 thiolester hydrolase activity; GO:0047617 acyl-CoA hydrolase activity;",null,null,"I","KOG3730","Acyl-CoA:dihydroxyactetone-phosphate acyltransferase DHAPAT","WP2533 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY;WP325 TRIACYLGLYCERIDE SYNTHESIS","http://www.wikipathways.org/instance/WP2533_r120261;http://www.wikipathways.org/instance/WP325_r116669",null,"R-HSA-1430728 Metabolism;R-HSA-1483166 Synthesis of PA;R-HSA-1483206 Glycerophospholipid biosynthesis;R-HSA-1483257 Phospholipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-75896 Plasmalogen biosynthesis;R-HSA-8848584 Wax and plasmalogen biosynthesis;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483166;https://reactome.org/PathwayBrowser/#/R-HSA-1483206;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-75896;https://reactome.org/PathwayBrowser/#/R-HSA-8848584;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","BILE ACID METABOLISM;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["O15234","Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2","CASC3",1.091266096,0.777837013,"nochange",2760.88,3246.97,2670.4,4001.43,3321.76,2147.09,0.912761529,1.073465454,0.882848363,1.32289392,1.098191424,0.709839309,"nucleus","K14323","CASC3; protein CASC3","hsa03013 Nucleocytoplasmic transport; hsa03015 mRNA surveillance pathway","GO:0000003 reproduction; GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000226 microtubule cytoskeleton organization; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0000578 embryonic axis specification; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007028 cytoplasm organization; GO:0007163 establishment or maintenance of cell polarity; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007316 pole plasm RNA localization; GO:0007318 pole plasm protein localization; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0008103 oocyte microtubule cytoskeleton polarization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008298 intracellular mRNA localization; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008380 RNA splicing; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009892 negative regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016325 oocyte microtubule cytoskeleton organization; GO:0019094 pole plasm mRNA localization; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity; GO:0030952 establishment or maintenance of cytoskeleton polarity; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035282 segmentation; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0045451 pole plasm oskar mRNA localization; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035145 exon-exon junction complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031369 translation initiation factor binding; GO:0031625 ubiquitin protein ligase binding; GO:0042802 identical protein binding; GO:0044389 ubiquitin-like protein ligase binding;","PF09405","PF09405 CASC3/Barentsz eIF4AIII binding","R","KOG4264","Nucleo-cytoplasmic protein MLN51",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-376176 Signaling by ROBO receptors;R-HSA-422475 Axon guidance;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-927802 Nonsense-Mediated Decay (NMD);R-HSA-9675108 Nervous system development;R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-9010553;https://reactome.org/PathwayBrowser/#/R-HSA-927802;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-975957"]
["O15239","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 OS=Homo sapiens OX=9606 GN=NDUFA1 PE=1 SV=1","NDUFA1",1.37528612,0.030143301,"nochange",3983.84,4247.41,3455.3,5934.31,5519.15,4618.89,0.86109464,0.918064477,0.746852361,1.282682671,1.192947127,0.998358725,"extracellular","K03945","NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0005829 cytosol; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045271 respiratory chain complex I; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0050136 NADH dehydrogenase (quinone) activity;",{"$nulls":5},"WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O15243","Leptin receptor gene-related protein OS=Homo sapiens OX=9606 GN=LEPROT PE=1 SV=1","LEPROT",0.692740705,0.271379308,"nochange",486.198,1042.23,926.287,487.241,667.951,545.289,0.702057857,1.504954279,1.337535462,0.703563923,0.964504683,0.787383796,"plasma membrane",{"$nulls":3},"GO:0006810 transport; GO:0007034 vacuolar transport; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0032509 endosome transport via multivesicular body sorting pathway; GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0045324 late endosome to vacuole transport; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060341 regulation of cellular localization; GO:0060398 regulation of growth hormone receptor signaling pathway; GO:0060400 negative regulation of growth hormone receptor signaling pathway; GO:0065007 biological regulation; GO:0071985 multivesicular body sorting pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903828 negative regulation of protein localization; GO:1904892 regulation of receptor signaling pathway via STAT; GO:1904893 negative regulation of receptor signaling pathway via STAT; GO:2000008 regulation of protein localization to cell surface; GO:2000009 negative regulation of protein localization to cell surface;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding;",null,null,"T","KOG2174","Leptin receptor gene-related protein"]
["O15247","Chloride intracellular channel protein 2 OS=Homo sapiens OX=9606 GN=CLIC2 PE=1 SV=3","CLIC2",1.118101961,0.101524026,"nochange",41900.5,47292,43350.6,53205.6,47987.5,47003.6,0.895501813,1.010729508,0.9264935,1.137115578,1.025593806,1.004565794,"cytoplasm","K05022",null,null,"GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006821 chloride transport; GO:0006937 regulation of muscle contraction; GO:0006942 regulation of striated muscle contraction; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008016 regulation of heart contraction; GO:0008152 metabolic process; GO:0009636 response to toxic substance; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010522 regulation of calcium ion transport into cytosol; GO:0010523 negative regulation of calcium ion transport into cytosol; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling; GO:0010959 regulation of metal ion transport; GO:0015698 inorganic anion transport; GO:0019722 calcium-mediated signaling; GO:0019932 second-messenger-mediated signaling; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0032409 regulation of transporter activity; GO:0032410 negative regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032413 negative regulation of ion transmembrane transporter activity; GO:0032879 regulation of localization; GO:0034220 ion transmembrane transport; GO:0034762 regulation of transmembrane transport; GO:0034763 negative regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034766 negative regulation of ion transmembrane transport; GO:0035556 intracellular signal transduction; GO:0042221 response to chemical; GO:0043269 regulation of ion transport; GO:0043271 negative regulation of ion transport; GO:0044057 regulation of system process; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050848 regulation of calcium-mediated signaling; GO:0050849 negative regulation of calcium-mediated signaling; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051279 regulation of release of sequestered calcium ion into cytosol; GO:0051280 negative regulation of release of sequestered calcium ion into cytosol; GO:0051282 regulation of sequestering of calcium ion; GO:0051284 positive regulation of sequestering of calcium ion; GO:0051716 cellular response to stimulus; GO:0051924 regulation of calcium ion transport; GO:0051926 negative regulation of calcium ion transport; GO:0055085 transmembrane transport; GO:0055117 regulation of cardiac muscle contraction; GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity; GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0090257 regulation of muscle system process; GO:0097237 cellular response to toxic substance; GO:0098656 anion transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098661 inorganic anion transmembrane transport; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1901019 regulation of calcium ion transmembrane transporter activity; GO:1901020 negative regulation of calcium ion transmembrane transporter activity; GO:1902476 chloride transmembrane transport; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903169 regulation of calcium ion transmembrane transport; GO:1903170 negative regulation of calcium ion transmembrane transport; GO:1903522 regulation of blood circulation; GO:1904062 regulation of cation transmembrane transport; GO:1904063 negative regulation of cation transmembrane transport; GO:1990748 cellular detoxification; GO:2001257 regulation of cation channel activity; GO:2001258 negative regulation of cation channel activity;","GO:0000139 Golgi membrane; GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0031090 organelle membrane; GO:0031253 cell projection membrane; GO:0031984 organelle subcompartment; GO:0036194 muscle cell projection; GO:0036195 muscle cell projection membrane; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0045177 apical part of cell; GO:0055120 striated muscle dense body; GO:0071944 cell periphery; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098852 lytic vacuole membrane; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004601 peroxidase activity; GO:0004602 glutathione peroxidase activity; GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005253 anion channel activity; GO:0005254 chloride channel activity; GO:0008509 anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015108 chloride transmembrane transporter activity; GO:0015267 channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0016209 antioxidant activity; GO:0016491 oxidoreductase activity; GO:0016684 oxidoreductase activity"," acting on peroxide as acceptor; GO:0022803 passive transmembrane transporter activity; GO:0022857 transmembrane transporter activity;","PF13409; PF13410","PF13409 Glutathione S-transferase"," N-terminal domain; PF13410 Glutathione S-transferase"," C-terminal domain","P","KOG1422","Intracellular Cl- channel CLIC"," contains GST domain",{"$nulls":3},"R-HSA-2672351 Stimuli-sensing channels;R-HSA-382551 Transport of small molecules;R-HSA-397014 Muscle contraction;R-HSA-5576891 Cardiac conduction;R-HSA-5578775 Ion homeostasis;R-HSA-983712 Ion channel transport","https://reactome.org/PathwayBrowser/#/R-HSA-2672351;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-397014;https://reactome.org/PathwayBrowser/#/R-HSA-5576891;https://reactome.org/PathwayBrowser/#/R-HSA-5578775;https://reactome.org/PathwayBrowser/#/R-HSA-983712","HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O15254","Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens OX=9606 GN=ACOX3 PE=1 SV=2","ACOX3",0.680662007,0.162407049,"nochange",2698.63,2154.86,2555.19,2062.32,975.597,2004.89,1.300389263,1.038362727,1.231269807,0.993770463,0.47011108,0.96609666,"cytoplasm","K00232","E1.3.3.6; acyl-CoA oxidase [EC:1.3.3.6]","hsa04936 Alcoholic liver disease; hsa03320 PPAR signaling pathway; hsa00071 Fatty acid degradation; hsa00410 beta-Alanine metabolism; hsa04146 Peroxisome; hsa01212 Fatty acid metabolism; hsa00592 alpha-Linolenic acid metabolism; hsa04024 cAMP signaling pathway; hsa00640 Propanoate metabolism; hsa01200 Carbon metabolism; hsa01040 Biosynthesis of unsaturated fatty acids; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0019395 fatty acid oxidation; GO:0019752 carboxylic acid metabolic process; GO:0030258 lipid modification; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase; GO:0034440 lipid oxidation; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045184 establishment of protein localization; GO:0046395 carboxylic acid catabolic process; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005782 peroxisomal matrix; GO:0005829 cytosol; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0003995 acyl-CoA dehydrogenase activity; GO:0003997 acyl-CoA oxidase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005504 fatty acid binding; GO:0005515 protein binding; GO:0008289 lipid binding; GO:0016402 pristanoyl-CoA oxidase activity; GO:0016491 oxidoreductase activity; GO:0016627 oxidoreductase activity"," acting on the CH-CH group of donors; GO:0016634 oxidoreductase activity"," acting on the CH-CH group of donors"," oxygen as acceptor; GO:0031406 carboxylic acid binding; GO:0033293 monocarboxylic acid binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043177 organic acid binding; GO:0050660 flavin adenine dinucleotide binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF02770","PF02770 Acyl-CoA dehydrogenase"," middle domain","IQ","KOG0135","Pristanoyl-CoA/acyl-CoA oxidase","WP4719 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX;WP4721 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX;WP4723 OMEGA3 OMEGA6 FATTY ACID SYNTHESIS;WP3942 PPAR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4719_r116307;http://www.wikipathways.org/instance/WP4721_r116526;http://www.wikipathways.org/instance/WP4723_r120315;http://www.wikipathways.org/instance/WP3942_r106517",null,"R-HSA-1430728 Metabolism;R-HSA-389887 Beta-oxidation of pristanoyl-CoA;R-HSA-390918 Peroxisomal lipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-389887;https://reactome.org/PathwayBrowser/#/R-HSA-390918;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["O15258","Protein RER1 OS=Homo sapiens OX=9606 GN=RER1 PE=1 SV=1","RER1",0.766950804,0.006521966,"down",28659.1,24785.3,26587.2,21119.2,20958.1,19303,1.215983945,1.05162154,1.128074794,0.896071688,0.889236337,0.819011696,"plasma membrane",{"$nulls":3},"GO:0001941 postsynaptic membrane organization; GO:0006810 transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0007528 neuromuscular junction development; GO:0008104 protein localization; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0043113 receptor clustering; GO:0048193 Golgi vesicle transport; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0050808 synapse organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051668 localization within membrane; GO:0060341 regulation of cellular localization; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071340 skeletal muscle acetylcholine-gated channel clustering; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0099173 postsynapse organization; GO:1903076 regulation of protein localization to plasma membrane; GO:1903078 positive regulation of protein localization to plasma membrane; GO:1903829 positive regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904377 positive regulation of protein localization to cell periphery; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030173 integral component of Golgi membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031228 intrinsic component of Golgi membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0033130 acetylcholine receptor binding;",null,null,"U","KOG1688","Golgi proteins involved in ER retention (RER)",{"$nulls":5},"PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O15260","Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN=SURF4 PE=1 SV=3","SURF4",0.876252155,0.03004375,"nochange",86981.1,80302.3,83184.8,74123.6,76719.9,68629.8,1.110535247,1.025263357,1.06206581,0.946376517,0.979524898,0.87623417,"plasma membrane","K20369",null,null,"GO:0001775 cell activation; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007275 multicellular organism development; GO:0009791 post-embryonic development; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033043 regulation of organelle organization; GO:0036230 granulocyte activation; GO:0040027 negative regulation of vulval development; GO:0040028 regulation of vulval development; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042119 neutrophil activation; GO:0042176 regulation of protein catabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045732 positive regulation of protein catabolic process; GO:0046903 secretion; GO:0048193 Golgi vesicle transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048580 regulation of post-embryonic development; GO:0048581 negative regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061062 regulation of nematode larval development; GO:0061064 negative regulation of nematode larval development; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:2000026 regulation of multicellular organismal development;","GO:0000139 Golgi membrane; GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0035577 azurophil granule membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045169 fusome; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098827 endoplasmic reticulum subcompartment; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;",{"$nulls":3},"U","KOG3998","Putative cargo transport protein ERV29",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6798695 Neutrophil degranulation;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688"]
["O15269","Serine palmitoyltransferase 1 OS=Homo sapiens OX=9606 GN=SPTLC1 PE=1 SV=1","SPTLC1",0.981640199,0.707835503,"nochange",20765.7,21565.9,23333.6,20465.2,22651.7,21342.7,0.957497725,0.994394612,1.075902518,0.943641796,1.044460395,0.984102953,"cytoplasm","K00654","SPT; serine palmitoyltransferase [EC:2.3.1.50]","hsa00600 Sphingolipid metabolism; hsa04071 Sphingolipid signaling pathway; hsa01100 Metabolic pathways","GO:0006066 alcohol metabolic process; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006665 sphingolipid metabolic process; GO:0006667 sphinganine metabolic process; GO:0006670 sphingosine metabolic process; GO:0006672 ceramide metabolic process; GO:0006684 sphingomyelin metabolic process; GO:0006686 sphingomyelin biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007163 establishment or maintenance of cell polarity; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0019216 regulation of lipid metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0030148 sphingolipid biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0034311 diol metabolic process; GO:0034312 diol biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045834 positive regulation of lipid metabolic process; GO:0046165 alcohol biosynthetic process; GO:0046173 polyol biosynthetic process; GO:0046467 membrane lipid biosynthetic process; GO:0046511 sphinganine biosynthetic process; GO:0046512 sphingosine biosynthetic process; GO:0046513 ceramide biosynthetic process; GO:0046519 sphingoid metabolic process; GO:0046520 sphingoid biosynthetic process; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090153 regulation of sphingolipid biosynthetic process; GO:0090154 positive regulation of sphingolipid biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:0097164 ammonium ion metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1904502 regulation of lipophagy; GO:1904504 positive regulation of lipophagy; GO:1905038 regulation of membrane lipid metabolic process;","GO:0002178 palmitoyltransferase complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0017059 serine C-palmitoyltransferase complex; GO:0031211 endoplasmic reticulum palmitoyltransferase complex; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0035339 SPOTS complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1905961 protein-cysteine S-palmitoyltransferase complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004758 serine C-palmitoyltransferase activity; GO:0016408 C-acyltransferase activity; GO:0016409 palmitoyltransferase activity; GO:0016454 C-palmitoyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups;","PF00155","PF00155 Aminotransferase class I and II","O","KOG1358","Serine palmitoyltransferase","WP4577 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY;WP5121 SPHINGOLIPID METABOLISM IN SENESCENCE;WP4726 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY;WP4725 SPHINGOLIPID METABOLISM OVERVIEW;WP1422 SPHINGOLIPID PATHWAY","http://www.wikipathways.org/instance/WP4577_r118444;http://www.wikipathways.org/instance/WP5121_r119472;http://www.wikipathways.org/instance/WP4726_r120323;http://www.wikipathways.org/instance/WP4725_r117175;http://www.wikipathways.org/instance/WP1422_r118359",null,"R-HSA-1430728 Metabolism;R-HSA-1660661 Sphingolipid de novo biosynthesis;R-HSA-428157 Sphingolipid metabolism;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1660661;https://reactome.org/PathwayBrowser/#/R-HSA-428157;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["O15270","Serine palmitoyltransferase 2 OS=Homo sapiens OX=9606 GN=SPTLC2 PE=1 SV=1","SPTLC2",0.602397105,8.16324E-4,"down",11302.1,10725.1,10637.2,6860.26,5886.71,6929.97,1.29558395,1.229441203,1.219365037,0.786406309,0.674806186,0.794397316,"cytoplasm","K00654","SPT; serine palmitoyltransferase [EC:2.3.1.50]","hsa00600 Sphingolipid metabolism; hsa04071 Sphingolipid signaling pathway; hsa01100 Metabolic pathways","GO:0006066 alcohol metabolic process; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006665 sphingolipid metabolic process; GO:0006667 sphinganine metabolic process; GO:0006670 sphingosine metabolic process; GO:0006672 ceramide metabolic process; GO:0006684 sphingomyelin metabolic process; GO:0006686 sphingomyelin biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007444 imaginal disc development; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0030148 sphingolipid biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034311 diol metabolic process; GO:0034312 diol biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0035295 tube development; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046165 alcohol biosynthetic process; GO:0046173 polyol biosynthetic process; GO:0046467 membrane lipid biosynthetic process; GO:0046511 sphinganine biosynthetic process; GO:0046512 sphingosine biosynthetic process; GO:0046513 ceramide biosynthetic process; GO:0046519 sphingoid metabolic process; GO:0046520 sphingoid biosynthetic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097164 ammonium ion metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1904502 regulation of lipophagy; GO:1904504 positive regulation of lipophagy;","GO:0002178 palmitoyltransferase complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0017059 serine C-palmitoyltransferase complex; GO:0031211 endoplasmic reticulum palmitoyltransferase complex; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1905961 protein-cysteine S-palmitoyltransferase complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004758 serine C-palmitoyltransferase activity; GO:0016408 C-acyltransferase activity; GO:0016409 palmitoyltransferase activity; GO:0016454 C-palmitoyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups;","PF00155","PF00155 Aminotransferase class I and II","O","KOG1357","Serine palmitoyltransferase","WP4726 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY;WP4725 SPHINGOLIPID METABOLISM OVERVIEW;WP1422 SPHINGOLIPID PATHWAY","http://www.wikipathways.org/instance/WP4726_r120323;http://www.wikipathways.org/instance/WP4725_r117175;http://www.wikipathways.org/instance/WP1422_r118359",null,"R-HSA-1430728 Metabolism;R-HSA-1660661 Sphingolipid de novo biosynthesis;R-HSA-428157 Sphingolipid metabolism;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1660661;https://reactome.org/PathwayBrowser/#/R-HSA-428157;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["O15287","Fanconi anemia group G protein OS=Homo sapiens OX=9606 GN=FANCG PE=1 SV=1","FANCG",0.821551589,0.336422246,"nochange",6672.49,7614.16,4668.24,5081.06,4510.55,5980.81,1.159515178,1.323154338,0.811225665,0.88296366,0.783823009,1.039318151,"mitochondria","K10894","FANCG; fanconi anemia group G protein","hsa03460 Fanconi anemia pathway","GO:0000003 reproduction; GO:0001541 ovarian follicle development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007548 sex differentiation; GO:0008152 metabolic process; GO:0008406 gonad development; GO:0008585 female gonad development; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036297 interstrand cross-link repair; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045137 development of primary sexual characteristics; GO:0046483 heterocycle metabolic process; GO:0046545 development of primary female sexual characteristics; GO:0046660 female sex differentiation; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0061458 reproductive system development; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043240 Fanconi anaemia nuclear complex; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",{"$nulls":5},"WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP2446 RETINOBLASTOMA GENE IN CANCER","http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP2446_r116593",null,"R-HSA-6783310 Fanconi Anemia Pathway;R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-6783310;https://reactome.org/PathwayBrowser/#/R-HSA-73894"]
["O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3","OGT",0.477564968,0.000209255,"down",97230.2,99522.2,109113,49179.2,44680,52211.4,1.290849147,1.321278234,1.448607767,0.652913687,0.593181335,0.693169829,"cytoplasm","K09667","OGT; protein O-GlcNAc transferase [EC:2.4.1.255]","hsa00514 Other types of O-glycan biosynthesis; hsa04931 Insulin resistance","GO:0000003 reproduction; GO:0001678 cellular glucose homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002237 response to molecule of bacterial origin; GO:0005975 carbohydrate metabolic process; GO:0005976 polysaccharide metabolic process; GO:0005977 glycogen metabolic process; GO:0006040 amino sugar metabolic process; GO:0006041 glucosamine metabolic process; GO:0006047 UDP-N-acetylglucosamine metabolic process; GO:0006048 UDP-N-acetylglucosamine biosynthetic process; GO:0006073 cellular glucan metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006109 regulation of carbohydrate metabolic process; GO:0006110 regulation of glycolytic process; GO:0006111 regulation of gluconeogenesis; GO:0006112 energy reserve metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006479 protein methylation; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006508 proteolysis; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007444 imaginal disc development; GO:0007584 response to nutrient; GO:0007610 behavior; GO:0007622 rhythmic behavior; GO:0007623 circadian rhythm; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008219 cell death; GO:0008361 regulation of cell size; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009226 nucleotide-sugar biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009791 post-embryonic development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010799 regulation of peptidyl-threonine phosphorylation; GO:0010801 negative regulation of peptidyl-threonine phosphorylation; GO:0010876 lipid localization; GO:0010906 regulation of glucose metabolic process; GO:0010941 regulation of cell death; GO:0012501 programmed cell death; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016311 dephosphorylation; GO:0016485 protein processing; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0016573 histone acetylation; GO:0016579 protein deubiquitination; GO:0018022 peptidyl-lysine methylation; GO:0018023 peptidyl-lysine trimethylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0019915 lipid storage; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030162 regulation of proteolysis; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030811 regulation of nucleotide catabolic process; GO:0030900 forebrain development; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031062 positive regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032922 circadian regulation of gene expression; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033135 regulation of peptidyl-serine phosphorylation; GO:0033137 negative regulation of peptidyl-serine phosphorylation; GO:0033157 regulation of intracellular protein transport; GO:0033500 carbohydrate homeostasis; GO:0033993 response to lipid; GO:0034284 response to monosaccharide; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034968 histone lysine methylation; GO:0035020 regulation of Rac protein signal transduction; GO:0035220 wing disc development; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040024 dauer larval development; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043255 regulation of carbohydrate biosynthetic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0043414 macromolecule methylation; GO:0043434 response to peptide hormone; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043470 regulation of carbohydrate catabolic process; GO:0043543 protein acylation; GO:0043933 protein-containing complex organization; GO:0043967 histone H4 acetylation; GO:0043981 histone H4-K5 acetylation; GO:0043982 histone H4-K8 acetylation; GO:0043984 histone H4-K16 acetylation; GO:0044042 glucan metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044264 cellular polysaccharide metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045475 locomotor rhythm; GO:0045793 positive regulation of cell size; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046349 amino sugar biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046578 regulation of Ras protein signal transduction; GO:0046626 regulation of insulin receptor signaling pathway; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048311 mitochondrion distribution; GO:0048312 intracellular distribution of mitochondria; GO:0048511 rhythmic process; GO:0048512 circadian behavior; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051235 maintenance of location; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051276 chromosome organization; GO:0051291 protein heterooligomerization; GO:0051568 histone H3-K4 methylation; GO:0051604 protein maturation; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0055082 cellular chemical homeostasis; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0061085 regulation of histone H3-K27 methylation; GO:0061087 positive regulation of histone H3-K27 methylation; GO:0061136 regulation of proteasomal protein catabolic process; GO:0062012 regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070085 glycosylation; GO:0070201 regulation of establishment of protein localization; GO:0070206 protein trimerization; GO:0070207 protein homotrimerization; GO:0070208 protein heterotrimerization; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071326 cellular response to monosaccharide stimulus; GO:0071331 cellular response to hexose stimulus; GO:0071333 cellular response to glucose stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071396 cellular response to lipid; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0080182 histone H3-K4 trimethylation; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090313 regulation of protein targeting to membrane; GO:0090315 negative regulation of protein targeting to membrane; GO:0090317 negative regulation of intracellular protein transport; GO:0097237 cellular response to toxic substance; GO:1900037 regulation of cellular response to hypoxia; GO:1900038 negative regulation of cellular response to hypoxia; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1901071 glucosamine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903426 regulation of reactive oxygen species biosynthetic process; GO:1903428 positive regulation of reactive oxygen species biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903533 regulation of protein targeting; GO:1903578 regulation of ATP metabolic process; GO:1903828 negative regulation of protein localization; GO:1903829 positive regulation of protein localization; GO:1904950 negative regulation of establishment of protein localization; GO:1905269 positive regulation of chromatin organization; GO:1905475 regulation of protein localization to membrane; GO:1905476 negative regulation of protein localization to membrane; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001169 regulation of ATP biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000123 histone acetyltransferase complex; GO:0000785 chromatin; GO:0000791 euchromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030141 secretory granule; GO:0031248 protein acetyltransferase complex; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042588 zymogen granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004722 protein serine/threonine phosphatase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008080 N-acetyltransferase activity; GO:0008134 transcription factor binding; GO:0008194 UDP-glycosyltransferase activity; GO:0008289 lipid binding; GO:0008375 acetylglucosaminyltransferase activity; GO:0016262 protein N-acetylglucosaminyltransferase activity; GO:0016407 acetyltransferase activity; GO:0016410 N-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0019904 protein domain specific binding; GO:0030246 carbohydrate binding; GO:0033218 amide binding; GO:0035091 phosphatidylinositol binding; GO:0036094 small molecule binding; GO:0042277 peptide binding; GO:0042578 phosphoric ester hydrolase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0048029 monosaccharide binding; GO:0097363 protein O-GlcNAc transferase activity; GO:0140096 catalytic activity"," acting on a protein; GO:1901981 phosphatidylinositol phosphate binding;",null,null,"GOT","KOG4626","O-linked N-acetylglucosamine transferase OGT","WP3594 CIRCADIAN RHYTHM GENES;WP2858 ECTODERM DIFFERENTIATION;WP5087 MALIGNANT PLEURAL MESOTHELIOMA","http://www.wikipathways.org/instance/WP3594_r117682;http://www.wikipathways.org/instance/WP2858_r116763;http://www.wikipathways.org/instance/WP5087_r120373",null,"R-HSA-3214847 HATs acetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-392499 Metabolism of proteins;R-HSA-4839726 Chromatin organization;R-HSA-5213460 RIPK1-mediated regulated necrosis;R-HSA-5218859 Regulated Necrosis;R-HSA-5357801 Programmed Cell Death;R-HSA-5675482 Regulation of necroptotic cell death;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-3214847;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5213460;https://reactome.org/PathwayBrowser/#/R-HSA-5218859;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-5675482;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689603;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["O15305","Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1","PMM2",0.661765778,0.002021294,"down",12421.5,12675.5,10830.5,7740.21,7641.21,8394.17,1.248327348,1.273853665,1.088436126,0.777870291,0.767921057,0.843591513,"cytoplasm","K17497","PMM; phosphomannomutase [EC:5.4.2.8]","hsa01250 Biosynthesis of nucleotide sugars; hsa01240 Biosynthesis of cofactors; hsa00051 Fructose and mannose metabolism; hsa00520 Amino sugar and nucleotide sugar metabolism; hsa01100 Metabolic pathways","GO:0001666 response to hypoxia; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006013 mannose metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006487 protein N-linked glycosylation; GO:0006605 protein targeting; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009226 nucleotide-sugar biosynthetic process; GO:0009298 GDP-mannose biosynthetic process; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0018130 heterocycle biosynthetic process; GO:0019318 hexose metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019673 GDP-mannose metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045047 protein targeting to ER; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0070085 glycosylation; GO:0070482 response to oxygen levels; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070972 protein localization to endoplasmic reticulum; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0072599 establishment of protein localization to endoplasmic reticulum; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0036477 somatodendritic compartment; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body;","GO:0003824 catalytic activity; GO:0004615 phosphomannomutase activity; GO:0016853 isomerase activity; GO:0016866 intramolecular transferase activity; GO:0016868 intramolecular transferase activity"," phosphotransferases;",null,null,"I","KOG3189","Phosphomannomutase","WP4521 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS;WP4758 NEPHROTIC SYNDROME","http://www.wikipathways.org/instance/WP4521_r119311;http://www.wikipathways.org/instance/WP4758_r108284",null,"R-HSA-1643685 Disease;R-HSA-3781865 Diseases of glycosylation;R-HSA-392499 Metabolism of proteins;R-HSA-4043911 Defective PMM2 causes PMM2-CDG;R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide"," LLO) and transfer to a nascent protein;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-446205 Synthesis of GDP-mannose;R-HSA-446219 Synthesis of substrates in N-glycan biosythesis;R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis;R-HSA-5668914 Diseases of metabolism;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-3781865;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4043911;https://reactome.org/PathwayBrowser/#/R-HSA-446193;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-446205;https://reactome.org/PathwayBrowser/#/R-HSA-446219;https://reactome.org/PathwayBrowser/#/R-HSA-5609975;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-597592","GLYCOLYSIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS"]
["O15315","DNA repair protein RAD51 homolog 2 OS=Homo sapiens OX=9606 GN=RAD51B PE=1 SV=2","RAD51B",0.894813976,0.230983786,"nochange",2518.33,2702.46,3151.52,2325.19,2509.59,2656.88,0.952471544,1.022112372,1.191953843,0.879422994,0.94916594,1.004873307,"nucleus","K10869","RAD51L1; RAD51-like protein 1","hsa03440 Homologous recombination","GO:0000003 reproduction; GO:0000280 nuclear division; GO:0000707 meiotic DNA recombinase assembly; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000730 DNA recombinase assembly; GO:0001701 in utero embryonic development; GO:0001824 blastocyst development; GO:0001832 blastocyst growth; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006312 mitotic recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007127 meiosis I; GO:0007131 reciprocal meiotic recombination; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009314 response to radiation; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010212 response to ionizing radiation; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010564 regulation of cell cycle process; GO:0010971 positive regulation of G2/M transition of mitotic cell cycle; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0035825 homologous recombination; GO:0040007 growth; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042148 strand invasion; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0045003 double-strand break repair via synthesis-dependent strand annealing; GO:0045787 positive regulation of cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048589 developmental growth; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051321 meiotic cell cycle; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060429 epithelium development; GO:0061053 somite development; GO:0061982 meiosis I cell cycle process; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0090735 DNA repair complex assembly; GO:0140013 meiotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902751 positive regulation of cell cycle G2/M phase transition; GO:1903046 meiotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033061 DNA recombinase mediator complex; GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000150 DNA strand exchange activity; GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003697 single-stranded DNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding;","PF08423","PF08423 Rad51","L","KOG1433","DNA repair protein RAD51/RHP55",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-1643685 Disease;R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693537 Resolution of D-Loop Structures;R-HSA-5693538 Homology Directed Repair;R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates;R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-73894 DNA Repair;R-HSA-9675135 Diseases of DNA repair;R-HSA-9675136 Diseases of DNA Double-Strand Break Repair;R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function;R-HSA-9701192 Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function;R-HSA-9701193 Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function;R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function;R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function;R-HSA-9709603 Impaired BRCA2 binding to PALB2;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-5685942;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693537;https://reactome.org/PathwayBrowser/#/R-HSA-5693538;https://reactome.org/PathwayBrowser/#/R-HSA-5693554;https://reactome.org/PathwayBrowser/#/R-HSA-5693567;https://reactome.org/PathwayBrowser/#/R-HSA-5693568;https://reactome.org/PathwayBrowser/#/R-HSA-5693579;https://reactome.org/PathwayBrowser/#/R-HSA-5693616;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-9675135;https://reactome.org/PathwayBrowser/#/R-HSA-9675136;https://reactome.org/PathwayBrowser/#/R-HSA-9701190;https://reactome.org/PathwayBrowser/#/R-HSA-9701192;https://reactome.org/PathwayBrowser/#/R-HSA-9701193;https://reactome.org/PathwayBrowser/#/R-HSA-9704331;https://reactome.org/PathwayBrowser/#/R-HSA-9704646;https://reactome.org/PathwayBrowser/#/R-HSA-9709603;https://reactome.org/PathwayBrowser/#/R-HSA-983231"]
["O15347","High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4","HMGB3",1.06697977,0.229486932,"nochange",42649.1,46500,49356.9,51160.6,48702.8,47919.7,0.893832842,0.974539373,1.034413815,1.072215463,1.020705294,1.004293213,"nucleus","K11296",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0032392 DNA geometric change; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0048856 anatomical structure development; GO:0051276 chromosome organization; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;",null,"GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0008301 DNA binding"," bending; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF09011; PF00505","PF09011 HMG-box domain; PF00505 HMG (high mobility group) box","R","KOG0381","HMG box-containing protein",{"$nulls":5},"E2F TARGETS;G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O15355","Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1","PPM1G",0.78131534,3.737752E-3,"down",36182.8,35946.6,36149.8,27081.8,26965.6,30552.8,1.125557213,1.118209617,1.124530665,0.842447664,0.83883297,0.95042187,"nucleus","K17499",null,null,"GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007049 cell cycle; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016311 dephosphorylation; GO:0019538 protein metabolic process; GO:0022402 cell cycle process; GO:0035970 peptidyl-threonine dephosphorylation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045786 negative regulation of cell cycle; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051726 regulation of cell cycle; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004722 protein serine/threonine phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"T","KOG0699","Serine/threonine protein phosphatase","WP411 MRNA PROCESSING;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP411_r117160;http://www.wikipathways.org/instance/WP3888_r116782",{"$nulls":3},"MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O15357","Phosphatidylinositol 3",4,"5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2","INPPL1",0.571060411,0.000172701,"down",22343.7,22907.3,21490.1,13138.6,13194,11780.6,1.278557007,1.310807473,1.229712086,0.751820383,0.754990496,0.674112554,"nucleus","K15909","SHIP2; phosphatidylinositol-3",4,"5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]","hsa04666 Fc gamma R-mediated phagocytosis; hsa04070 Phosphatidylinositol signaling system; hsa04662 B cell receptor signaling pathway; hsa00562 Inositol phosphate metabolism; hsa04910 Insulin signaling pathway; hsa01100 Metabolic pathways","GO:0001501 skeletal system development; GO:0001503 ossification; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001958 endochondral ossification; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002685 regulation of leukocyte migration; GO:0002686 negative regulation of leukocyte migration; GO:0002688 regulation of leukocyte chemotaxis; GO:0002689 negative regulation of leukocyte chemotaxis; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006006 glucose metabolic process; GO:0006066 alcohol metabolic process; GO:0006275 regulation of DNA replication; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006469 negative regulation of protein kinase activity; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0008156 negative regulation of DNA replication; GO:0008285 negative regulation of cell population proliferation; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway; GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016311 dephosphorylation; GO:0016477 cell migration; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019318 hexose metabolic process; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030509 BMP signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031529 ruffle organization; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032879 regulation of localization; GO:0032957 inositol trisphosphate metabolic process; GO:0033673 negative regulation of kinase activity; GO:0034097 response to cytokine; GO:0036075 replacement ossification; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040036 regulation of fibroblast growth factor receptor signaling pathway; GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043434 response to peptide hormone; GO:0043549 regulation of kinase activity; GO:0043567 regulation of insulin-like growth factor receptor signaling pathway; GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway; GO:0043647 inositol phosphate metabolic process; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048705 skeletal system morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0050920 regulation of chemotaxis; GO:0050922 negative regulation of chemotaxis; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060348 bone development; GO:0060349 bone morphogenesis; GO:0060350 endochondral bone morphogenesis; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071622 regulation of granulocyte chemotaxis; GO:0071623 negative regulation of granulocyte chemotaxis; GO:0071704 organic substance metabolic process; GO:0071772 response to BMP; GO:0071773 cellular response to BMP stimulus; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0090022 regulation of neutrophil chemotaxis; GO:0090024 negative regulation of neutrophil chemotaxis; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090288 negative regulation of cellular response to growth factor stimulus; GO:0090407 organophosphate biosynthetic process; GO:0097178 ruffle assembly; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901652 response to peptide; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902622 regulation of neutrophil migration; GO:1902623 negative regulation of neutrophil migration; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030175 filopodium; GO:0031252 cell leading edge; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0098858 actin-based cell projection; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004445 inositol-polyphosphate 5-phosphatase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008289 lipid binding; GO:0016314 phosphatidylinositol-3",4,"5-trisphosphate 3-phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0019904 protein domain specific binding; GO:0034485 phosphatidylinositol-3",4,"5-trisphosphate 5-phosphatase activity; GO:0034594 phosphatidylinositol trisphosphate phosphatase activity; GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity; GO:0035091 phosphatidylinositol binding; GO:0042169 SH2 domain binding; GO:0042578 phosphoric ester hydrolase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046030 inositol trisphosphate phosphatase activity; GO:0052659 inositol-1",3,4,"5-tetrakisphosphate 5-phosphatase activity; GO:0052743 inositol tetrakisphosphate phosphatase activity; GO:0052745 inositol phosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity; GO:1901981 phosphatidylinositol phosphate binding;","PF00017; PF03372; PF00536","PF00017 SH2 domain; PF03372 Endonuclease/Exonuclease/phosphatase family; PF00536 SAM domain (Sterile alpha motif)","R","KOG4384","Uncharacterized SAM domain protein","WP437 EGFEGFR SIGNALING PATHWAY;WP481 INSULIN SIGNALING","http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP481_r120562",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1430728 Metabolism;R-HSA-1483249 Inositol phosphate metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-168256 Immune System;R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol;R-HSA-449147 Signaling by Interleukins;R-HSA-451927 Interleukin-2 family signaling;R-HSA-512988 Interleukin-3"," Interleukin-5 and GM-CSF signaling;R-HSA-556833 Metabolism of lipids;R-HSA-912526 Interleukin receptor SHC signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483249;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1855204;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-451927;https://reactome.org/PathwayBrowser/#/R-HSA-512988;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-912526","APICAL JUNCTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION"]
["O15371","Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1","EIF3D",0.907149398,0.005154564,"nochange",59840.7,58756.5,61033.3,55693,53126,54132.7,1.048052701,1.029063974,1.068939951,0.975409697,0.930451144,0.948082533,"cytoplasm","K03251",null,null,"GO:0001732 formation of cytoplasmic translation initiation complex; GO:0002181 cytoplasmic translation; GO:0002183 cytoplasmic translational initiation; GO:0002191 cap-dependent translational initiation; GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0019080 viral gene expression; GO:0019081 viral translation; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045727 positive regulation of translation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0075522 IRES-dependent viral translational initiation; GO:0075525 viral translational termination-reinitiation; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902415 regulation of mRNA binding; GO:1902416 positive regulation of mRNA binding; GO:1905214 regulation of RNA binding; GO:1905216 positive regulation of RNA binding; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005852 eukaryotic translation initiation factor 3 complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071541 eukaryotic translation initiation factor 3 complex"," eIF3m;","GO:0000339 RNA cap binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003743 translation initiation factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0097159 organic cyclic compound binding; GO:0098808 mRNA cap binding; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG2479","Translation initiation factor 3"," subunit d (eIF-3d)","WP5027 NSP1 FROM SARSCOV2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL;WP107 TRANSLATION FACTORS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5027_r120060;http://www.wikipathways.org/instance/WP107_r117851;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-392499 Metabolism of proteins;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72649 Translation initiation complex formation;R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72695 Formation of the ternary complex"," and subsequently"," the 43S complex;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-156827;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72649;https://reactome.org/PathwayBrowser/#/R-HSA-72662;https://reactome.org/PathwayBrowser/#/R-HSA-72689;https://reactome.org/PathwayBrowser/#/R-HSA-72695;https://reactome.org/PathwayBrowser/#/R-HSA-72702;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72766","ALLOGRAFT REJECTION;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O15372","Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1","EIF3H",0.947819928,0.091760422,"nochange",93264.1,88879.2,85953.3,84217.3,84548.3,85341.7,1.071582575,1.021201106,0.987583203,0.967636971,0.971440083,0.980556062,"cytoplasm","K03247","EIF3H; translation initiation factor 3 subunit H","hsa05162 Measles","GO:0001944 vasculature development; GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0008152 metabolic process; GO:0008593 regulation of Notch signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034248 regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045747 positive regulation of Notch signaling pathway; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048880 sensory system development; GO:0048882 lateral line development; GO:0048925 lateral line system development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005852 eukaryotic translation initiation factor 3 complex; GO:0032991 protein-containing complex; GO:0071541 eukaryotic translation initiation factor 3 complex"," eIF3m;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003743 translation initiation factor activity; GO:0005488 binding; GO:0008135 translation factor activity"," RNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG1560","Translation initiation factor 3"," subunit h (eIF-3h)","WP4630 MEASLES VIRUS INFECTION;WP5027 NSP1 FROM SARSCOV2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL;WP107 TRANSLATION FACTORS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4630_r120771;http://www.wikipathways.org/instance/WP5027_r120060;http://www.wikipathways.org/instance/WP107_r117851;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-392499 Metabolism of proteins;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72649 Translation initiation complex formation;R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72695 Formation of the ternary complex"," and subsequently"," the 43S complex;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-156827;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72649;https://reactome.org/PathwayBrowser/#/R-HSA-72662;https://reactome.org/PathwayBrowser/#/R-HSA-72689;https://reactome.org/PathwayBrowser/#/R-HSA-72695;https://reactome.org/PathwayBrowser/#/R-HSA-72702;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["O15379","Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2","HDAC3",1.023864485,0.664387207,"nochange",15724.4,13714.5,15137.8,15826.8,15544.3,14269.4,1.045769543,0.912098802,1.006757026,1.052579774,1.033791782,0.949003073,"cytoplasm","K11404","HDAC3; histone deacetylase 3 [EC:3.5.1.98]","hsa04613 Neutrophil extracellular trap formation; hsa05203 Viral carcinogenesis; hsa04919 Thyroid hormone signaling pathway; hsa05034 Alcoholism","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000226 microtubule cytoskeleton organization; GO:0001525 angiogenesis; GO:0001558 regulation of cell growth; GO:0001568 blood vessel development; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001889 liver development; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001944 vasculature development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006476 protein deacetylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007406 negative regulation of neuroblast proliferation; GO:0007548 sex differentiation; GO:0007623 circadian rhythm; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016202 regulation of striated muscle tissue development; GO:0016570 histone modification; GO:0016575 histone deacetylation; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030307 positive regulation of cell growth; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031960 response to corticosteroid; GO:0032006 regulation of TOR signaling; GO:0032008 positive regulation of TOR signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032507 maintenance of protein location in cell; GO:0032652 regulation of interleukin-1 production; GO:0032680 regulation of tumor necrosis factor production; GO:0032692 negative regulation of interleukin-1 production; GO:0032720 negative regulation of tumor necrosis factor production; GO:0032870 cellular response to hormone stimulus; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032922 circadian regulation of gene expression; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034405 response to fluid shear stress; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035601 protein deacylation; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042262 DNA protection; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043523 regulation of neuron apoptotic process; GO:0043525 positive regulation of neuron apoptotic process; GO:0043696 dedifferentiation; GO:0043697 cell dedifferentiation; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045138 nematode male tail tip morphogenesis; GO:0045185 maintenance of protein location; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045843 negative regulation of striated muscle tissue development; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046483 heterocycle metabolic process; GO:0046661 male sex differentiation; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046823 negative regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046825 regulation of protein export from nucleus; GO:0046826 negative regulation of protein export from nucleus; GO:0048511 rhythmic process; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048634 regulation of muscle organ development; GO:0048635 negative regulation of muscle organ development; GO:0048638 regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048880 sensory system development; GO:0048881 mechanosensory lateral line system development; GO:0048882 lateral line development; GO:0048915 posterior lateral line system development; GO:0048916 posterior lateral line development; GO:0048925 lateral line system development; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051154 negative regulation of striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051225 spindle assembly; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051384 response to glucocorticoid; GO:0051457 maintenance of protein location in nucleus; GO:0051641 cellular localization; GO:0051651 maintenance of location in cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0055024 regulation of cardiac muscle tissue development; GO:0055026 negative regulation of cardiac muscle tissue development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060548 negative regulation of cell death; GO:0061008 hepaticobiliary system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0070932 histone H3 deacetylation; GO:0070933 histone H4 deacetylation; GO:0071107 response to parathyroid hormone; GO:0071214 cellular response to abiotic stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071374 cellular response to parathyroid hormone stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071498 cellular response to fluid shear stress; GO:0071548 response to dexamethasone; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072091 regulation of stem cell proliferation; GO:0072359 circulatory system development; GO:0072595 maintenance of protein localization in organelle; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0090316 positive regulation of intracellular protein transport; GO:0090317 negative regulation of intracellular protein transport; GO:0090598 male anatomical structure morphogenesis; GO:0097327 response to antineoplastic agent; GO:0098732 macromolecule deacylation; GO:0104004 cellular response to environmental stimulus; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901654 response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901861 regulation of muscle tissue development; GO:1901862 negative regulation of muscle tissue development; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902692 regulation of neuroblast proliferation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production; GO:1903828 negative regulation of protein localization; GO:1903829 positive regulation of protein localization; GO:1904035 regulation of epithelial cell apoptotic process; GO:1904037 positive regulation of epithelial cell apoptotic process; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904950 negative regulation of establishment of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905207 regulation of cardiocyte differentiation; GO:1905208 negative regulation of cardiocyte differentiation; GO:1990679 histone H4-K12 deacetylation; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000647 negative regulation of stem cell proliferation; GO:2000674 regulation of type B pancreatic cell apoptotic process; GO:2000676 positive regulation of type B pancreatic cell apoptotic process; GO:2000725 regulation of cardiac muscle cell differentiation; GO:2000726 negative regulation of cardiac muscle cell differentiation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000118 histone deacetylase complex; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0017053 transcription repressor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:1902494 catalytic complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0004407 histone deacetylase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016811 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in linear amides; GO:0019213 deacetylase activity; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030332 cyclin binding; GO:0031490 chromatin DNA binding; GO:0033558 protein deacetylase activity; GO:0042826 histone deacetylase binding; GO:0051020 GTPase binding; GO:0051059 NF-kappaB binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00850","PF00850 Histone deacetylase domain","B","KOG1342","Histone deacetylase complex"," catalytic component RPD3","WP4949 16P112 PROXIMAL DELETION SYNDROME;WP4657 22Q112 COPY NUMBER VARIATION SYNDROME;WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP3594 CIRCADIAN RHYTHM GENES;WP3996 ETHANOL EFFECTS ON HISTONE MODIFICATIONS;WP4754 IL18 SIGNALING PATHWAY;WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR;WP2064 NEURAL CREST DIFFERENTIATION;WP4533 TRANSCRIPTION COFACTORS SKI AND SKIL PROTEIN PARTNERS","http://www.wikipathways.org/instance/WP4949_r115778;http://www.wikipathways.org/instance/WP4657_r120007;http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP3594_r117682;http://www.wikipathways.org/instance/WP3996_r107156;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP3414_r106735;http://www.wikipathways.org/instance/WP2064_r117162;http://www.wikipathways.org/instance/WP4533_r103380","Transcription factor","R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1368071 NR1D1 (REV-ERBA) represses gene expression;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-1592230 Mitochondrial biogenesis;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-193670 p75NTR negatively regulates cell cycle via SC1;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-1980143 Signaling by NOTCH1;R-HSA-1989781 PPARA activates gene expression;R-HSA-201556 Signaling by ALK;R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription;R-HSA-212436 Generic Transcription Pathway;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis;R-HSA-2262752 Cellular responses to stress;R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer;R-HSA-2644603 Signaling by NOTCH1 in Cancer;R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants;R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer;R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;R-HSA-3214815 HDACs deacetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-350054 Notch-HLH transcription pathway;R-HSA-381340 Transcriptional regulation of white adipocyte differentiation;R-HSA-390466 Chaperonin-mediated protein folding;R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-400253 Circadian Clock;R-HSA-4839726 Chromatin organization;R-HSA-556833 Metabolism of lipids;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-6807070 PTEN Regulation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73887 Death Receptor Signalling;R-HSA-74160 Gene expression (Transcription);R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8940973 RUNX2 regulates osteoblast differentiation;R-HSA-8941326 RUNX2 regulates bone development;R-HSA-8943724 Regulation of PTEN gene transcription;R-HSA-8953897 Cellular responses to stimuli;R-HSA-8986944 Transcriptional Regulation by MECP2;R-HSA-9005891 Loss of function of MECP2 in Rett syndrome;R-HSA-9005895 Pervasive developmental disorders;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex;R-HSA-9022692 Regulation of MECP2 expression and activity;R-HSA-9024446 NR1H2 and NR1H3-mediated signaling;R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9675151 Disorders of Developmental Biology;R-HSA-9697154 Disorders of Nervous System Development;R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9707616 Heme signaling;R-HSA-9711123 Cellular response to chemical stress",null,"P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O15381","Nuclear valosin-containing protein-like OS=Homo sapiens OX=9606 GN=NVL PE=1 SV=1","NVL",0.578441437,{"v":8.7392e-06,"d":"8.74E-06"},"down",14582.4,14964.5,14483.4,8231.75,8536.3,8700.9,1.258925816,1.291913222,1.250378961,0.710662345,0.736954715,0.751164941,"nucleus","K14571","RIX7; ribosome biogenesis ATPase","hsa03008 Ribosome biogenesis in eukaryotes","GO:0006950 response to stress; GO:0007154 cell communication; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010876 lipid localization; GO:0010941 regulation of cell death; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019915 lipid storage; GO:0022613 ribonucleoprotein complex biogenesis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0042254 ribosome biogenesis; GO:0042594 response to starvation; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048580 regulation of post-embryonic development; GO:0048582 positive regulation of post-embryonic development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0051972 regulation of telomerase activity; GO:0051973 positive regulation of telomerase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061062 regulation of nematode larval development; GO:0061063 positive regulation of nematode larval development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071496 cellular response to external stimulus; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000573 positive regulation of DNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005697 telomerase holoenzyme complex; GO:0005730 nucleolus; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043021 ribonucleoprotein complex binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990275 preribosome binding;","PF16725; PF00004; PF17862","PF16725 Nucleolin binding domain; PF00004 ATPase family associated with various cellular activities (AAA); PF17862 AAA+ lid domain","O","KOG0733","Nuclear AAA ATPase (VCP subfamily)"]
["O15382","Branched-chain-amino-acid aminotransferase"," mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2","BCAT2",0.881716609,0.029247117,"nochange",28950,29239.2,29315.9,23997.2,25778.9,27378.6,1.054902289,1.065440381,1.068235234,0.874428367,0.939351317,0.997642412,"mitochondria","K00826","E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]","hsa00270 Cysteine and methionine metabolism; hsa01240 Biosynthesis of cofactors; hsa00290 Valine"," leucine and isoleucine biosynthesis; hsa00770 Pantothenate and CoA biosynthesis; hsa01210 2-Oxocarboxylic acid metabolism; hsa01230 Biosynthesis of amino acids; hsa01100 Metabolic pathways; hsa00280 Valine"," leucine and isoleucine degradation","GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0006082 organic acid metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006549 isoleucine metabolic process; GO:0006550 isoleucine catabolic process; GO:0006551 leucine metabolic process; GO:0006573 valine metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007589 body fluid secretion; GO:0007595 lactation; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008652 cellular amino acid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009063 cellular amino acid catabolic process; GO:0009081 branched-chain amino acid metabolic process; GO:0009082 branched-chain amino acid biosynthetic process; GO:0009083 branched-chain amino acid catabolic process; GO:0009098 leucine biosynthetic process; GO:0009099 valine biosynthetic process; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010817 regulation of hormone levels; GO:0016053 organic acid biosynthetic process; GO:0016054 organic acid catabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022402 cell cycle process; GO:0030879 mammary gland development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034097 response to cytokine; GO:0042221 response to chemical; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0046394 carboxylic acid biosynthetic process; GO:0046395 carboxylic acid catabolic process; GO:0046903 secretion; GO:0048513 animal organ development; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901606 alpha-amino acid catabolic process; GO:1901607 alpha-amino acid biosynthetic process; GO:1903047 mitotic cell cycle process; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004084 branched-chain-amino-acid transaminase activity; GO:0008483 transaminase activity; GO:0016740 transferase activity; GO:0016769 transferase activity"," transferring nitrogenous groups;","PF01063","PF01063 Amino-transferase class IV","E","KOG0975","Branched chain aminotransferase BCAT1"," pyridoxal phosphate enzymes type IV superfamily","WP3940 ONECARBON METABOLISM AND RELATED PATHWAYS","http://www.wikipathways.org/instance/WP3940_r119248",null,"R-HSA-1430728 Metabolism;R-HSA-70895 Branched-chain amino acid catabolism;R-HSA-71291 Metabolism of amino acids and derivatives","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70895;https://reactome.org/PathwayBrowser/#/R-HSA-71291"]
["O15389","Sialic acid-binding Ig-like lectin 5 OS=Homo sapiens OX=9606 GN=SIGLEC5 PE=1 SV=1","SIGLEC5",0.714782585,0.149276818,"nochange",4959.32,3089.24,3561.25,2850.36,3276.6,2171.53,1.494648966,0.931040822,1.073296062,0.859046729,0.987507723,0.654459698,"extracellular","K06549",null,null,"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002682 regulation of immune system process; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0006810 transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0008285 negative regulation of cell population proliferation; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0022610 biological adhesion; GO:0023052 signaling; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032940 secretion by cell; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045087 innate immune response; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050727 regulation of inflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0080134 regulation of response to stress; GO:0106014 regulation of inflammatory response to wounding; GO:0106015 negative regulation of inflammatory response to wounding; GO:1900424 regulation of defense response to bacterium; GO:1900425 negative regulation of defense response to bacterium; GO:1903034 regulation of response to wounding; GO:1903035 negative regulation of response to wounding;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0009897 external side of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0035579 specific granule membrane; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0070820 tertiary granule; GO:0070821 tertiary granule membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:0101003 ficolin-1-rich granule membrane;","GO:0004888 transmembrane signaling receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019904 protein domain specific binding; GO:0030246 carbohydrate binding; GO:0031406 carboxylic acid binding; GO:0033691 sialic acid binding; GO:0036094 small molecule binding; GO:0038023 signaling receptor activity; GO:0042169 SH2 domain binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043177 organic acid binding; GO:0048029 monosaccharide binding; GO:0060089 molecular transducer activity; GO:0097367 carbohydrate derivative binding;","PF07686","PF07686 Immunoglobulin V-set domain",{"$nulls":6},"R-HSA-1280218 Adaptive Immune System;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-198933;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O15391","Transcription factor YY2 OS=Homo sapiens OX=9606 GN=YY2 PE=2 SV=1","YY2",1.013543225,0.833902434,"nochange",30468.6,27571,37336.5,30542.8,32921.9,33203.1,0.951926096,0.861396795,1.16649891,0.954244316,1.028574196,1.037359687,"nucleus","K09201",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006265 DNA topological change; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010225 response to UV-C; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016358 dendrite development; GO:0016579 protein deubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032479 regulation of type I interferon production; GO:0032480 negative regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032648 regulation of interferon-beta production; GO:0032688 negative regulation of interferon-beta production; GO:0032774 RNA biosynthetic process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034644 cellular response to UV; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071103 DNA conformation change; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0104004 cellular response to environmental stimulus; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005704 polytene chromosome band; GO:0031011 Ino80 complex; GO:0031519 PcG protein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033202 DNA helicase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0097346 INO80-type complex; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1904949 ATPase complex;","GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003714 transcription corepressor activity; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0031490 chromatin DNA binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046332 SMAD binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["O15392","Baculoviral IAP repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=3","BIRC5",1.381992159,0.315802067,"nochange","NA",2076.89,2241.34,1988.42,3439.94,3523.28,"NA",0.782558533,0.844522215,0.749223617,1.296146835,1.3275488,"extracellular","K08731","BIRC5; baculoviral IAP repeat-containing protein 5","hsa04215 Apoptosis - multiple species; hsa05161 Hepatitis B; hsa05200 Pathways in cancer; hsa05207 Chemical carcinogenesis - receptor activation; hsa04390 Hippo signaling pathway; hsa04210 Apoptosis; hsa05210 Colorectal cancer; hsa01524 Platinum drug resistance","GO:0000003 reproduction; GO:0000022 mitotic spindle elongation; GO:0000070 mitotic sister chromatid segregation; GO:0000075 cell cycle checkpoint signaling; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000281 mitotic cytokinesis; GO:0000819 sister chromatid segregation; GO:0000910 cytokinesis; GO:0000912 assembly of actomyosin apparatus involved in cytokinesis; GO:0000915 actomyosin contractile ring assembly; GO:0001944 vasculature development; GO:0002791 regulation of peptide secretion; GO:0003008 system process; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0007088 regulation of mitotic nuclear division; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007094 mitotic spindle assembly checkpoint signaling; GO:0007096 regulation of exit from mitosis; GO:0007110 meiosis I cytokinesis; GO:0007111 meiosis II cytokinesis; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0007610 behavior; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008284 positive regulation of cell population proliferation; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010466 negative regulation of peptidase activity; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010951 negative regulation of endopeptidase activity; GO:0010955 negative regulation of protein processing; GO:0010965 regulation of mitotic sister chromatid separation; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0016567 protein ubiquitination; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0018991 oviposition; GO:0019098 reproductive behavior; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030162 regulation of proteolysis; GO:0030261 chromosome condensation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031032 actomyosin structure organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0031536 positive regulation of exit from mitosis; GO:0031577 spindle checkpoint signaling; GO:0031960 response to corticosteroid; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032506 cytokinetic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0033206 meiotic cytokinesis; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0036211 protein modification process; GO:0036215 response to stem cell factor; GO:0036216 cellular response to stem cell factor stimulus; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040039 inductive cell migration; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043170 macromolecule metabolic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043543 protein acylation; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044837 actomyosin contractile ring organization; GO:0044839 cell cycle G2/M phase transition; GO:0045132 meiotic chromosome segregation; GO:0045471 response to ethanol; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045840 positive regulation of mitotic nuclear division; GO:0045841 negative regulation of mitotic metaphase/anaphase transition; GO:0045861 negative regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046677 response to antibiotic; GO:0046883 regulation of hormone secretion; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050000 chromosome localization; GO:0050678 regulation of epithelial cell proliferation; GO:0050708 regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050954 sensory perception of mechanical stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051225 spindle assembly; GO:0051231 spindle elongation; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051255 spindle midzone assembly; GO:0051256 mitotic spindle midzone assembly; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051303 establishment of chromosome localization; GO:0051321 meiotic cell cycle; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051384 response to glucocorticoid; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060548 negative regulation of cell death; GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0061469 regulation of type B pancreatic cell proliferation; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0061982 meiosis I cell cycle process; GO:0061983 meiosis II cell cycle process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070613 regulation of protein processing; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071103 DNA conformation change; GO:0071173 spindle assembly checkpoint signaling; GO:0071174 mitotic spindle checkpoint signaling; GO:0071236 cellular response to antibiotic; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071361 cellular response to ethanol; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090307 mitotic spindle assembly; GO:0097237 cellular response to toxic substance; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097340 inhibition of cysteine-type endopeptidase activity; GO:0097341 zymogen inhibition; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903317 regulation of protein maturation; GO:1903318 negative regulation of protein maturation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005814 centriole; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005876 spindle microtubule; GO:0005881 cytoplasmic microtubule; GO:0005886 plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0030496 midbody; GO:0031021 interphase microtubule organizing center; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032133 chromosome passenger complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045177 apical part of cell; GO:0051233 spindle midzone; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0072687 meiotic spindle; GO:0098590 plasma membrane region; GO:0098687 chromosomal region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:1990023 mitotic spindle midzone; GO:1990385 meiotic spindle midzone;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0004869 cysteine-type endopeptidase inhibitor activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008134 transcription factor binding; GO:0008270 zinc ion binding; GO:0015631 tubulin binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0042974 retinoic acid receptor binding; GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046965 retinoid X receptor binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0050897 cobalt ion binding; GO:0051020 GTPase binding; GO:0051087 chaperone binding; GO:0051427 hormone receptor binding; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF00653","PF00653 Inhibitor of Apoptosis domain","DR","KOG1101","Apoptosis inhibitor IAP1 and related BIR domain proteins","WP254 APOPTOSIS;WP1772 APOPTOSIS MODULATION AND SIGNALING;WP2864 APOPTOSISRELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER;WP4216 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER;WP4300 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS;WP4659 GASTRIN SIGNALING PATHWAY;WP4666 HEPATITIS B INFECTION;WP3646 HEPATITIS C AND HEPATOCELLULAR CARCINOMA;WP395 IL4 SIGNALING PATHWAY;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY;WP3614 PHOTODYNAMIC THERAPYINDUCED HIF1 SURVIVAL SIGNALING;WP3617 PHOTODYNAMIC THERAPYINDUCED NFKB SURVIVAL SIGNALING;WP3303 RAC1PAK1P38MMP2 PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP254_r118382;http://www.wikipathways.org/instance/WP1772_r120736;http://www.wikipathways.org/instance/WP2864_r108133;http://www.wikipathways.org/instance/WP4216_r119088;http://www.wikipathways.org/instance/WP4300_r105311;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP3646_r116732;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP2332_r120725;http://www.wikipathways.org/instance/WP5115_r120597;http://www.wikipathways.org/instance/WP3614_r106542;http://www.wikipathways.org/instance/WP3617_r106541;http://www.wikipathways.org/instance/WP3303_r120561;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-212436 Generic Transcription Pathway;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-392499 Metabolism of proteins;R-HSA-449147 Signaling by Interleukins;R-HSA-4615885 SUMOylation of DNA replication proteins;R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-597592 Post-translational protein modification;R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling;R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8951664 Neddylation;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-4615885;https://reactome.org/PathwayBrowser/#/R-HSA-5633008;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6785807;https://reactome.org/PathwayBrowser/#/R-HSA-6803205;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8951664;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","E2F TARGETS;G2M CHECKPOINT;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O15394","Neural cell adhesion molecule 2 OS=Homo sapiens OX=9606 GN=NCAM2 PE=1 SV=2","NCAM2",1.264542235,0.119670221,"nochange",4104.58,4546.08,3710.92,6240.56,4932.03,4459.15,0.879762743,0.974392462,0.795386899,1.337581966,1.057115769,0.95576016,"peroxisome","K06491","NCAM; neural cell adhesion molecule","hsa03265 Virion - Lyssavirus; hsa04514 Cell adhesion molecules; hsa05020 Prion disease","GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001746 Bolwig's organ morphogenesis; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002376 immune system process; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules; GO:0007158 neuron cell-cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007413 axonal fasciculation; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007444 imaginal disc development; GO:0007483 genital disc morphogenesis; GO:0007484 imaginal disc-derived genitalia development; GO:0007485 imaginal disc-derived male genitalia development; GO:0007528 neuromuscular junction development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007613 memory; GO:0007614 short-term memory; GO:0007635 chemosensory behavior; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008045 motor neuron axon guidance; GO:0008152 metabolic process; GO:0008306 associative learning; GO:0008355 olfactory learning; GO:0008360 regulation of cell shape; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009605 response to external stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0014041 regulation of neuron maturation; GO:0014043 negative regulation of neuron maturation; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016319 mushroom body development; GO:0019221 cytokine-mediated signaling pathway; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030534 adult behavior; GO:0030539 male genitalia development; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0034097 response to cytokine; GO:0034341 response to interferon-gamma; GO:0035112 genitalia morphogenesis; GO:0035126 post-embryonic genitalia morphogenesis; GO:0035150 regulation of tube size; GO:0035151 regulation of tube size"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035158 regulation of tube diameter"," open tracheal system; GO:0035159 regulation of tube length"," open tracheal system; GO:0035215 genital disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035296 regulation of tube diameter; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042048 olfactory behavior; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0045471 response to ethanol; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0046661 male sex differentiation; GO:0046677 response to antibiotic; GO:0048149 behavioral response to ethanol; GO:0048167 regulation of synaptic plasticity; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048608 reproductive structure development; GO:0048638 regulation of developmental growth; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048803 imaginal disc-derived male genitalia morphogenesis; GO:0048805 imaginal disc-derived genitalia morphogenesis; GO:0048806 genitalia development; GO:0048808 male genitalia morphogenesis; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050808 synapse organization; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0055034 Bolwig's organ development; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060333 interferon-gamma-mediated signaling pathway; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060562 epithelial tube morphogenesis; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0071679 commissural neuron axon guidance; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072499 photoreceptor cell axon guidance; GO:0072553 terminal button organization; GO:0090066 regulation of anatomical structure size; GO:0090596 sensory organ morphogenesis; GO:0090598 male anatomical structure morphogenesis; GO:0097305 response to alcohol; GO:0097485 neuron projection guidance; GO:0098609 cell-cell adhesion; GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules; GO:0099172 presynapse organization; GO:0099177 regulation of trans-synaptic signaling; GO:0106030 neuron projection fasciculation; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1903429 regulation of cell maturation; GO:1903430 negative regulation of cell maturation; GO:1904396 regulation of neuromuscular junction development; GO:1904799 regulation of neuron remodeling; GO:1904800 negative regulation of neuron remodeling; GO:2000026 regulation of multicellular organismal development; GO:2001260 regulation of semaphorin-plexin signaling pathway;","GO:0000139 Golgi membrane; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0009897 external side of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016604 nuclear body; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031594 neuromuscular junction; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031984 organelle subcompartment; GO:0036062 presynaptic periactive zone; GO:0042734 presynaptic membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0048786 presynaptic active zone; GO:0061174 type I terminal bouton; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097482 muscle cell postsynaptic specialization; GO:0098552 side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0098975 postsynapse of neuromuscular junction; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0051020 GTPase binding; GO:0098772 molecular function regulator;","PF07679; PF13927; PF00041","PF07679 Immunoglobulin I-set domain; PF13927 Immunoglobulin domain; PF00041 Fibronectin type III domain","T","KOG3510","FOG: Immunoglobulin C-2 Type/fibronectin type III domains"]
["O15397","Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2","IPO8",1.188339782,0.017787587,"nochange",22737.1,20657.5,20885.5,24747.1,27133.5,24506,0.96982868,0.881125384,0.8908505,1.055563257,1.157352806,1.045279373,"cytoplasm","K18755","IPO8; importin-8","hsa03013 Nucleocytoplasmic transport","GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0001654 eye development; GO:0001708 cell fate specification; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0006469 negative regulation of protein kinase activity; GO:0006606 protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007517 muscle organ development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008104 protein localization; GO:0008283 cell population proliferation; GO:0008586 imaginal disc-derived wing vein morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010941 regulation of cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016203 muscle attachment; GO:0016318 ommatidial rotation; GO:0017038 protein import; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030575 nuclear body organization; GO:0030576 Cajal body organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033673 negative regulation of kinase activity; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035309 wing and notum subfield formation; GO:0035311 wing cell fate specification; GO:0038127 ERBB signaling pathway; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042067 establishment of ommatidial planar polarity; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0042675 compound eye cone cell differentiation; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0045165 cell fate commitment; GO:0045184 establishment of protein localization; GO:0045465 R8 cell differentiation; GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045786 negative regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048592 eye morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0055085 transmembrane transport; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060538 skeletal muscle organ development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060573 cell fate specification involved in pattern specification; GO:0060581 cell fate commitment involved in pattern specification; GO:0060964 regulation of gene silencing by miRNA; GO:0060966 regulation of gene silencing by RNA; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0090596 sensory organ morphogenesis; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904030 negative regulation of cyclin-dependent protein kinase activity;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015030 Cajal body; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016604 nuclear body; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0099568 cytoplasmic region;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0015399 primary active transmembrane transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017069 snRNA binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019899 enzyme binding; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0030234 enzyme regulator activity; GO:0030619 U1 snRNA binding; GO:0030620 U2 snRNA binding; GO:0030621 U4 snRNA binding; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0046332 SMAD binding; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901363 heterocyclic compound binding;",null,null,"YU","KOG1991","Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily)",{"$nulls":3},"R-HSA-211000 Gene Silencing by RNA;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-211000;https://reactome.org/PathwayBrowser/#/R-HSA-5578749;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["O15400","Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4","STX7",0.92920488,0.375425921,"nochange",48880.5,41499.6,52206,44785,43145.5,44561.2,1.066182004,0.905189732,1.138717846,0.976850913,0.941090121,0.971969385,"plasma membrane","K08488","STX7; syntaxin 7","hsa04145 Phagosome; hsa04130 SNARE interactions in vesicular transport","GO:0001505 regulation of neurotransmitter levels; GO:0001910 regulation of leukocyte mediated cytotoxicity; GO:0001912 positive regulation of leukocyte mediated cytotoxicity; GO:0001914 regulation of T cell mediated cytotoxicity; GO:0001916 positive regulation of T cell mediated cytotoxicity; GO:0002165 instar larval or pupal development; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002703 regulation of leukocyte mediated immunity; GO:0002705 positive regulation of leukocyte mediated immunity; GO:0002706 regulation of lymphocyte mediated immunity; GO:0002708 positive regulation of lymphocyte mediated immunity; GO:0002709 regulation of T cell mediated immunity; GO:0002711 positive regulation of T cell mediated immunity; GO:0002819 regulation of adaptive immune response; GO:0002821 positive regulation of adaptive immune response; GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006904 vesicle docking involved in exocytosis; GO:0006906 vesicle fusion; GO:0006996 organelle organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0008285 negative regulation of cell population proliferation; GO:0008333 endosome to lysosome transport; GO:0009791 post-embryonic development; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016081 synaptic vesicle docking; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0023061 signal release; GO:0030100 regulation of endocytosis; GO:0031341 regulation of cell killing; GO:0031343 positive regulation of cell killing; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034058 endosomal vesicle fusion; GO:0034613 cellular protein localization; GO:0035073 pupariation; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035210 prepupal development; GO:0035264 multicellular organism growth; GO:0040007 growth; GO:0042127 regulation of cell population proliferation; GO:0042886 amide transport; GO:0044085 cellular component biogenesis; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045807 positive regulation of endocytosis; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048227 plasma membrane to endosome transport; GO:0048278 vesicle docking; GO:0048284 organelle fusion; GO:0048489 synaptic vesicle transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048589 developmental growth; GO:0048856 anatomical structure development; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090174 organelle membrane fusion; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering; GO:1902683 regulation of receptor localization to synapse; GO:1902685 positive regulation of receptor localization to synapse; GO:1903076 regulation of protein localization to plasma membrane; GO:1904375 regulation of protein localization to cell periphery; GO:1905475 regulation of protein localization to membrane;","GO:0000323 lytic vacuole; GO:0001772 immunological synapse; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005886 plasma membrane; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030139 endocytic vesicle; GO:0030141 secretory granule; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042582 azurophil granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0055037 recycling endosome; GO:0070820 tertiary granule; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098793 presynapse; GO:0098796 membrane protein complex; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0000149 SNARE binding; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008200 ion channel inhibitor activity; GO:0016247 channel regulator activity; GO:0016248 channel inhibitor activity; GO:0017081 chloride channel regulator activity; GO:0019869 chloride channel inhibitor activity; GO:0019905 syntaxin binding; GO:0044877 protein-containing complex binding; GO:0098772 molecular function regulator; GO:0099106 ion channel regulator activity;","PF14523","PF14523 Syntaxin-like protein","U","KOG0811","SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17",{"$nulls":5},"PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O15427","Monocarboxylate transporter 4 OS=Homo sapiens OX=9606 GN=SLC16A3 PE=1 SV=1","SLC16A3",0.748027484,{"v":2.31403e-05,"d":"2.31E-05"},"down",46706.8,47098.2,45737.6,34893.2,34178.4,35310.1,1.148884305,1.158511883,1.125044122,0.858295791,0.840713287,0.868550612,"plasma membrane","K08180","SLC16A3; MFS transporter"," MCT family"," solute carrier family 16 (monocarboxylic acid transporters)"," member 3","hsa05230 Central carbon metabolism in cancer","GO:0002376 immune system process; GO:0006082 organic acid metabolic process; GO:0006090 pyruvate metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006928 movement of cell or subcellular component; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015727 lactate transport; GO:0015849 organic acid transport; GO:0015850 organic hydroxy compound transport; GO:0016477 cell migration; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0034220 ion transmembrane transport; GO:0035873 lactate transmembrane transport; GO:0035879 plasma membrane lactate transport; GO:0040011 locomotion; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044281 small molecule metabolic process; GO:0046942 carboxylic acid transport; GO:0048870 cell motility; GO:0050900 leukocyte migration; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051674 localization of cell; GO:0055085 transmembrane transport; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0098656 anion transmembrane transport; GO:1903825 organic acid transmembrane transport; GO:1905039 carboxylic acid transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0005215 transporter activity; GO:0005342 organic acid transmembrane transporter activity; GO:0008028 monocarboxylic acid transmembrane transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015129 lactate transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0046943 carboxylic acid transmembrane transporter activity; GO:1901618 organic hydroxy compound transmembrane transporter activity;",null,null,"G","KOG2504","Monocarboxylate transporter","WP4290 METABOLIC REPROGRAMMING IN COLON CANCER","http://www.wikipathways.org/instance/WP4290_r118611",null,"R-HSA-109582 Hemostasis;R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-210991 Basigin interactions;R-HSA-382551 Transport of small molecules;R-HSA-425366 Transport of bile salts and organic acids"," metal ions and amine compounds;R-HSA-425407 SLC-mediated transmembrane transport;R-HSA-433692 Proton-coupled monocarboxylate transport;R-HSA-70268 Pyruvate metabolism;R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-202733;https://reactome.org/PathwayBrowser/#/R-HSA-210991;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-425366;https://reactome.org/PathwayBrowser/#/R-HSA-425407;https://reactome.org/PathwayBrowser/#/R-HSA-433692;https://reactome.org/PathwayBrowser/#/R-HSA-70268;https://reactome.org/PathwayBrowser/#/R-HSA-71406","GLYCOLYSIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS"]
["O15431","High affinity copper uptake protein 1 OS=Homo sapiens OX=9606 GN=SLC31A1 PE=1 SV=1","SLC31A1",0.741864872,0.076858037,"nochange",5955.89,5348.31,5301.87,3148.4,4442.55,4728.51,1.235425591,1.109395748,1.099762736,0.653070143,0.921514662,0.98083112,"plasma membrane","K14686","SLC31A1; solute carrier family 31 (copper transporter)"," member 1","hsa04978 Mineral absorption; hsa01524 Platinum drug resistance","GO:0000041 transition metal ion transport; GO:0002027 regulation of heart rate; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006825 copper ion transport; GO:0006855 xenobiotic transmembrane transport; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006878 cellular copper ion homeostasis; GO:0008016 regulation of heart contraction; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0015677 copper ion import; GO:0015679 plasma membrane copper ion transport; GO:0019725 cellular homeostasis; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0034220 ion transmembrane transport; GO:0035434 copper ion transmembrane transport; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0044057 regulation of system process; GO:0046916 cellular transition metal ion homeostasis; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055070 copper ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0072718 response to cisplatin; GO:0072719 cellular response to cisplatin; GO:0097237 cellular response to toxic substance; GO:0097327 response to antineoplastic agent; GO:0098655 cation transmembrane transport; GO:0098657 import into cell; GO:0098659 inorganic cation import across plasma membrane; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098705 copper ion import across plasma membrane; GO:0098739 import across plasma membrane; GO:0098771 inorganic ion homeostasis; GO:0099587 inorganic ion import across plasma membrane; GO:1903522 regulation of blood circulation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005770 late endosome; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0036477 somatodendritic compartment; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0044297 cell body; GO:0055037 recycling endosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle;","GO:0005215 transporter activity; GO:0005375 copper ion transmembrane transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0042802 identical protein binding; GO:0046873 metal ion transmembrane transporter activity; GO:0046915 transition metal ion transmembrane transporter activity;",null,null,"P","KOG3386","Copper transporter","WP3286 COPPER HOMEOSTASIS","http://www.wikipathways.org/instance/WP3286_r106367",null,"R-HSA-382551 Transport of small molecules;R-HSA-425366 Transport of bile salts and organic acids"," metal ions and amine compounds;R-HSA-425407 SLC-mediated transmembrane transport;R-HSA-425410 Metal ion SLC transporters","https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-425366;https://reactome.org/PathwayBrowser/#/R-HSA-425407;https://reactome.org/PathwayBrowser/#/R-HSA-425410","INFLAMMATORY RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE"]
["O15439","ATP-binding cassette sub-family C member 4 OS=Homo sapiens OX=9606 GN=ABCC4 PE=1 SV=3","ABCC4",0.518676849,{"v":1.37686e-06,"d":"1.38E-06"},"down",94111.6,96527.7,92430.4,49619.3,48531.8,48670.6,1.313516856,1.347238396,1.290052325,0.692537231,0.67735898,0.679296213,"plasma membrane","K05673","ABCC4; ATP-binding cassette"," subfamily C (CFTR/MRP)"," member 4","hsa04024 cAMP signaling pathway; hsa04976 Bile secretion; hsa01523 Antifolate resistance; hsa02010 ABC transporters","GO:0001666 response to hypoxia; GO:0002576 platelet degranulation; GO:0003002 regionalization; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007444 imaginal disc development; GO:0007447 imaginal disc pattern formation; GO:0007450 dorsal/ventral pattern formation"," imaginal disc; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009888 tissue development; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010043 response to zinc ion; GO:0010259 multicellular organism aging; GO:0010876 lipid localization; GO:0015698 inorganic anion transport; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015732 prostaglandin transport; GO:0015849 organic acid transport; GO:0015908 fatty acid transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0032309 icosanoid secretion; GO:0032310 prostaglandin secretion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034059 response to anoxia; GO:0034220 ion transmembrane transport; GO:0035220 wing disc development; GO:0035222 wing disc pattern formation; GO:0035295 tube development; GO:0036293 response to decreased oxygen levels; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0044085 cellular component biogenesis; GO:0044782 cilium organization; GO:0045055 regulated exocytosis; GO:0046688 response to copper ion; GO:0046717 acid secretion; GO:0046903 secretion; GO:0046942 carboxylic acid transport; GO:0048190 wing disc dorsal/ventral pattern formation; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0060271 cilium assembly; GO:0060429 epithelium development; GO:0070482 response to oxygen levels; GO:0070925 organelle assembly; GO:0071702 organic substance transport; GO:0071715 icosanoid transport; GO:0071840 cellular component organization or biogenesis; GO:0098656 anion transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1901571 fatty acid derivative transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016323 basolateral plasma membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031088 platelet dense granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0042827 platelet dense granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0099503 secretory vesicle;","GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015562 efflux transmembrane transporter activity; GO:0015662 P-type ion transporter activity; GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; GO:0016462 pyrophosphatase activity; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0022804 active transmembrane transporter activity; GO:0022853 active ion transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0042625 ATPase-coupled ion transmembrane transporter activity; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity;","PF00005","PF00005 ABC transporter","Q","KOG0054","Multidrug resistance-associated protein/mitoxantrone resistance protein"," ABC superfamily","WP4707 ASPIRIN AND MIRNAS;WP2289 DRUG INDUCTION OF BILE ACID PATHWAY;WP2858 ECTODERM DIFFERENTIATION;WP1601 FLUOROPYRIMIDINE ACTIVITY;WP5066 FOXA2 PATHWAY;WP2884 NRF2 PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP3612 PHOTODYNAMIC THERAPYINDUCED NFE2L2 NRF2 SURVIVAL SIGNALING;WP2876 PREGNANE X RECEPTOR PATHWAY;WP98 PROSTAGLANDIN SYNTHESIS AND REGULATION;WP4917 PROXIMAL TUBULE TRANSPORT;WP3945 TYROBP CAUSAL NETWORK IN MICROGLIA","http://www.wikipathways.org/instance/WP4707_r116586;http://www.wikipathways.org/instance/WP2289_r120498;http://www.wikipathways.org/instance/WP2858_r116763;http://www.wikipathways.org/instance/WP1601_r120496;http://www.wikipathways.org/instance/WP5066_r116631;http://www.wikipathways.org/instance/WP2884_r106658;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP3612_r106540;http://www.wikipathways.org/instance/WP2876_r116466;http://www.wikipathways.org/instance/WP98_r117172;http://www.wikipathways.org/instance/WP4917_r119111;http://www.wikipathways.org/instance/WP3945_r116679",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-9748784 Drug ADME;R-HSA-9748787 Azathioprine ADME;R-HSA-9753281 Paracetamol ADME","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-382556;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005;https://reactome.org/PathwayBrowser/#/R-HSA-9748784;https://reactome.org/PathwayBrowser/#/R-HSA-9748787;https://reactome.org/PathwayBrowser/#/R-HSA-9753281","ANDROGEN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE"]
["O15446","DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1","POLR1G",0.873117918,0.111240129,"nochange",18162,19948.7,18462.3,17555.6,17331.4,14507.9,1.028349151,1.129513749,1.045352413,0.994014225,0.981319815,0.821450647,"nucleus","K25436","POLR1G; DNA-directed RNA polymerase I subunit RPA34","hsa03020 RNA polymerase","GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006353 DNA-templated transcription"," termination; GO:0006360 transcription by RNA polymerase I; GO:0006361 transcription initiation from RNA polymerase I promoter; GO:0006363 termination of RNA polymerase I transcription; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009303 rRNA transcription; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023052 signaling; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0040029 regulation of gene expression"," epigenetic; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098781 ncRNA transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000120 RNA polymerase I transcription regulator complex; GO:0000428 DNA-directed RNA polymerase complex; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005730 nucleolus; GO:0005736 RNA polymerase I complex; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;",{"$nulls":9},"R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-5250913 Positive epigenetic regulation of rRNA expression;R-HSA-5250924 B-WICH complex positively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-73762 RNA Polymerase I Transcription Initiation;R-HSA-73772 RNA Polymerase I Promoter Escape;R-HSA-73854 RNA Polymerase I Promoter Clearance;R-HSA-73863 RNA Polymerase I Transcription Termination;R-HSA-73864 RNA Polymerase I Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-427413;https://reactome.org/PathwayBrowser/#/R-HSA-5250913;https://reactome.org/PathwayBrowser/#/R-HSA-5250924;https://reactome.org/PathwayBrowser/#/R-HSA-5250941;https://reactome.org/PathwayBrowser/#/R-HSA-73762;https://reactome.org/PathwayBrowser/#/R-HSA-73772;https://reactome.org/PathwayBrowser/#/R-HSA-73854;https://reactome.org/PathwayBrowser/#/R-HSA-73863;https://reactome.org/PathwayBrowser/#/R-HSA-73864;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["O15498","Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1","YKT6",1.584174858,0.000223109,"up",14117.2,13458.7,14817.4,22251.2,23357.1,21550.1,0.773180151,0.737114988,0.811529168,1.218668446,1.279237109,1.180270137,"cytoplasm","K08516","YKT6; synaptobrevin homolog YKT6","hsa04130 SNARE interactions in vesicular transport","GO:0006810 transport; GO:0006887 exocytosis; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006903 vesicle targeting; GO:0006904 vesicle docking involved in exocytosis; GO:0006906 vesicle fusion; GO:0006996 organelle organization; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0022406 membrane docking; GO:0032940 secretion by cell; GO:0042147 retrograde transport"," endosome to Golgi; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048278 vesicle docking; GO:0048284 organelle fusion; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0071840 cellular component organization or biogenesis; GO:0090174 organelle membrane fusion; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005768 endosome; GO:0005783 endoplasmic reticulum; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030425 dendrite; GO:0030659 cytoplasmic vesicle membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body; GO:0071944 cell periphery; GO:0097440 apical dendrite; GO:0097441 basal dendrite; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0120025 plasma membrane bounded cell projection;","GO:0000149 SNARE binding; GO:0003824 catalytic activity; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016409 palmitoyltransferase activity; GO:0016417 S-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0019706 protein-cysteine S-palmitoyltransferase activity; GO:0019707 protein-cysteine S-acyltransferase activity; GO:0140096 catalytic activity"," acting on a protein;","PF13774","PF13774 Regulated-SNARE-like domain","U","KOG0861","SNARE protein YKT6"," synaptobrevin/VAMP syperfamily",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811438 Intra-Golgi traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013408 RHOG GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-948021 Transport to the Golgi and subsequent modification;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811438;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013408;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-948021;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MTORC1 SIGNALING;PROTEIN SECRETION;UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["O15504","Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1","NUP42",0.812170146,0.14293315,"nochange",6611.2,7333.44,8790.83,6253.94,5299.12,6912.01,0.962783497,1.067962701,1.280201182,0.910756024,0.77170639,1.006590205,"nucleus","K14321","NUPL2; nucleoporin-like protein 2","hsa03013 Nucleocytoplasmic transport","GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0010467 gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016032 viral process; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport;","GO:0001750 photoreceptor outer segment; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005929 cilium; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097730 non-motile cilium; GO:0097731 9+0 non-motile cilium; GO:0097733 photoreceptor cell cilium; GO:0120025 plasma membrane bounded cell projection;","GO:0005049 nuclear export signal receptor activity; GO:0140104 molecular carrier activity; GO:0140142 nucleocytoplasmic carrier activity;",{"$nulls":8},"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1430728 Metabolism;R-HSA-159227 Transport of the SLBP independent Mature mRNA;R-HSA-159230 Transport of the SLBP Dependant Mature mRNA;R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript;R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts;R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-165054 Rev-mediated nuclear export of HIV RNA;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus;R-HSA-168276 NS1 Mediated Effects on Host Pathways;R-HSA-168325 Viral Messenger RNA Synthesis;R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery;R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein;R-HSA-176033 Interactions of Vpr with host cellular proteins;R-HSA-177243 Interactions of Rev with host cellular proteins;R-HSA-180746 Nuclear import of Rev protein;R-HSA-180910 Vpr-mediated nuclear import of PICs;R-HSA-191859 snRNP Assembly;R-HSA-194441 Metabolism of non-coding RNA;R-HSA-211000 Gene Silencing by RNA;R-HSA-2262752 Cellular responses to stress;R-HSA-2980766 Nuclear Envelope Breakdown;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3232142 SUMOylation of ubiquitinylation proteins;R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly;R-HSA-3371453 Regulation of HSF1-mediated heat shock response;R-HSA-3371556 Cellular response to heat stress;R-HSA-392499 Metabolism of proteins;R-HSA-4085377 SUMOylation of SUMOylation proteins;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-4570464 SUMOylation of RNA binding proteins;R-HSA-4615885 SUMOylation of DNA replication proteins;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-5619102 SLC transporter disorders;R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-6784531 tRNA processing in the nucleus;R-HSA-68875 Mitotic Prophase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-70171 Glycolysis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-72306 tRNA processing;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-913531 Interferon Signaling;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9610379 HCMV Late Events;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions"]
["O15511","Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3","ARPC5",1.008751592,0.639101578,"nochange",142506,138085,138647,144006,141556,137345,1.01530734,0.983809202,0.987813263,1.025994336,1.00853891,0.97853695,"cytoplasm","K05754","ARPC5; actin related protein 2/3 complex"," subunit 5","hsa04666 Fc gamma R-mediated phagocytosis; hsa04530 Tight junction; hsa05131 Shigellosis; hsa05100 Bacterial invasion of epithelial cells; hsa05132 Salmonella infection; hsa04810 Regulation of actin cytoskeleton; hsa05130 Pathogenic Escherichia coli infection; hsa04144 Endocytosis; hsa05135 Yersinia infection","GO:0000902 cell morphogenesis; GO:0001667 ameboidal-type cell migration; GO:0001775 cell activation; GO:0002009 morphogenesis of an epithelium; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0014812 muscle cell migration; GO:0014909 smooth muscle cell migration; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0021761 limbic system development; GO:0021769 orbitofrontal cortex development; GO:0023052 signaling; GO:0030011 maintenance of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030900 forebrain development; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0034314 Arp2/3 complex-mediated actin nucleation; GO:0036230 granulocyte activation; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0040011 locomotion; GO:0042119 neutrophil activation; GO:0043254 regulation of protein-containing complex assembly; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045010 actin nucleation; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048013 ephrin receptor signaling pathway; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051639 actin filament network formation; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060322 head development; GO:0060429 epithelium development; GO:0061024 membrane organization; GO:0061842 microtubule organizing center localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097435 supramolecular fiber organization; GO:0097581 lamellipodium organization; GO:0098657 import into cell; GO:0110053 regulation of actin filament organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005885 Arp2/3 protein complex; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0030027 lamellipodium; GO:0030141 secretory granule; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1904813 ficolin-1-rich granule lumen;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;","PF04699","PF04699 ARP2/3 complex 16 kDa subunit (p16-Arc)","Z","KOG3380","Actin-related protein Arp2/3 complex"," subunit ARPC5","WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION;WP51 REGULATION OF ACTIN CYTOSKELETON","http://www.wikipathways.org/instance/WP2272_r118427;http://www.wikipathways.org/instance/WP51_r116716",null,"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199991 Membrane Trafficking;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-3928662 EPHB-mediated forward signaling;R-HSA-422475 Axon guidance;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-6798695 Neutrophil degranulation;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-3928662;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663213;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O15514","DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1","POLR2D",0.883289226,0.362576816,"nochange",7492.01,6230.53,5299.44,5238.2,5335.29,6228.42,1.254806778,1.043526541,0.887582002,0.877325159,0.893586375,1.043173145,"cytoplasm","K03012","RPB4; DNA-directed RNA polymerase II subunit RPB4","hsa05016 Huntington disease; hsa03020 RNA polymerase","GO:0000288 nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006354 DNA-templated transcription"," elongation; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0008543 fibroblast growth factor receptor signaling pathway; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009266 response to temperature stimulus; GO:0009301 snRNA transcription; GO:0009408 response to heat; GO:0009452 7-methylguanosine RNA capping; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016073 snRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023052 signaling; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0031990 mRNA export from nucleus in response to heat stress; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032774 RNA biosynthetic process; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; GO:0034605 cellular response to heat; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0034660 ncRNA metabolic process; GO:0036260 RNA capping; GO:0042221 response to chemical; GO:0042795 snRNA transcription by RNA polymerase II; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0045184 establishment of protein localization; GO:0045727 positive regulation of translation; GO:0045948 positive regulation of translational initiation; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060964 regulation of gene silencing by miRNA; GO:0060966 regulation of gene silencing by RNA; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071166 ribonucleoprotein complex localization; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071774 response to fibroblast growth factor; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098781 ncRNA transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005665 RNA polymerase II"," core complex; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005705 polytene chromosome interband; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016591 RNA polymerase II"," holoenzyme; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1990234 transferase complex; GO:1990904 ribonucleoprotein complex;","GO:0003824 catalytic activity; GO:0003899 DNA-directed 5'-3' RNA polymerase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0031369 translation initiation factor binding; GO:0034062 5'-3' RNA polymerase activity; GO:0097747 RNA polymerase activity; GO:0140098 catalytic activity"," acting on RNA;",null,null,"K","KOG2351","RNA polymerase II"," fourth largest subunit","WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-113418 Formation of the Early Elongation Complex;R-HSA-1226099 Signaling by FGFR in disease;R-HSA-1266738 Developmental Biology;R-HSA-157579 Telomere Maintenance;R-HSA-162582 Signal Transduction;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167158 Formation of the HIV-1 Early Elongation Complex;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167161 HIV Transcription Initiation;R-HSA-167162 RNA Polymerase II HIV Promoter Escape;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation;R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat;R-HSA-167243 Tat-mediated HIV elongation arrest and recovery;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-167287 HIV elongation arrest and recovery;R-HSA-167290 Pausing and recovery of HIV elongation;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-168325 Viral Messenger RNA Synthesis;R-HSA-1839126 FGFR2 mutant receptor activation;R-HSA-190236 Signaling by FGFR;R-HSA-203927 MicroRNA (miRNA) biogenesis;R-HSA-211000 Gene Silencing by RNA;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-5654738 Signaling by FGFR2;R-HSA-5655253 Signaling by FGFR2 in disease;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6803529 FGFR2 alternative splicing;R-HSA-6807505 RNA polymerase II transcribes snRNA genes;R-HSA-72086 mRNA Capping;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72165 mRNA Splicing - Minor Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73776 RNA Polymerase II Promoter Escape;R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73886 Chromosome Maintenance;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-75953 RNA Polymerase II Transcription Initiation;R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance;R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8851708 Signaling by FGFR2 IIIa TM;R-HSA-8939211 ESR-mediated signaling;R-HSA-8953854 Metabolism of RNA;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9018519 Estrogen-dependent gene expression;R-HSA-9670095 Inhibition of DNA recombination at telomere",null,"DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O15523","ATP-dependent RNA helicase DDX3Y OS=Homo sapiens OX=9606 GN=DDX3Y PE=1 SV=2","DDX3Y",1.117559638,0.067296625,"nochange",15048.4,15557.3,15082.6,18108.1,17280.4,15670.9,0.933256294,0.964816735,0.935377275,1.123009643,1.07167819,0.971861863,"nucleus","K17642",null,null,"GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0001558 regulation of cell growth; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002168 instar larval development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006970 response to osmotic stress; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007530 sex determination; GO:0007552 metamorphosis; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010466 negative regulation of peptidase activity; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010501 RNA secondary structure unwinding; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010623 programmed cell death involved in cell development; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010951 negative regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0012502 induction of programmed cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0016070 RNA metabolic process; GO:0016192 vesicle-mediated transport; GO:0016246 RNA interference; GO:0016441 posttranscriptional gene silencing; GO:0017148 negative regulation of translation; GO:0018992 germ-line sex determination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022612 gland morphogenesis; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030307 positive regulation of cell growth; GO:0030308 negative regulation of cell growth; GO:0030718 germ-line stem cell population maintenance; GO:0031047 gene silencing by RNA; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032392 DNA geometric change; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032508 DNA duplex unwinding; GO:0032642 regulation of chemokine production; GO:0032648 regulation of interferon-beta production; GO:0032722 positive regulation of chemokine production; GO:0032728 positive regulation of interferon-beta production; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0033993 response to lipid; GO:0034063 stress granule assembly; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035070 salivary gland histolysis; GO:0035071 salivary gland cell autophagic cell death; GO:0035072 ecdysone-mediated induction of salivary gland cell autophagic cell death; GO:0035075 response to ecdysone; GO:0035078 induction of programmed cell death by ecdysone; GO:0035081 induction of programmed cell death by hormones; GO:0035194 post-transcriptional gene silencing by RNA; GO:0035272 exocrine system development; GO:0035556 intracellular signal transduction; GO:0036098 male germ-line stem cell population maintenance; GO:0036230 granulocyte activation; GO:0036314 response to sterol; GO:0040008 regulation of growth; GO:0040019 positive regulation of embryonic development; GO:0040021 hermaphrodite germ-line sex determination; GO:0040029 regulation of gene expression"," epigenetic; GO:0042006 masculinization of hermaphroditic germ-line; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042254 ribosome biogenesis; GO:0042255 ribosome assembly; GO:0042256 mature ribosome assembly; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043043 peptide biosynthetic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043254 regulation of protein-containing complex assembly; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043549 regulation of kinase activity; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0045087 innate immune response; GO:0045321 leukocyte activation; GO:0045727 positive regulation of translation; GO:0045787 positive regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045948 positive regulation of translational initiation; GO:0045995 regulation of embryonic development; GO:0046483 heterocycle metabolic process; GO:0046685 response to arsenic-containing substance; GO:0046903 secretion; GO:0048102 autophagic cell death; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048707 instar larval or pupal morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051641 cellular localization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060033 anatomical structure regression; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071103 DNA conformation change; GO:0071214 cellular response to abiotic stimulus; GO:0071243 cellular response to arsenic-containing substance; GO:0071470 cellular response to osmotic stress; GO:0071649 regulation of chemokine (C-C motif) ligand 5 production; GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080154 regulation of fertilization; GO:0090068 positive regulation of cell cycle process; GO:0090263 positive regulation of canonical Wnt signaling pathway; GO:0090304 nucleic acid metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097191 extrinsic apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097305 response to alcohol; GO:0098727 maintenance of cell number; GO:0098813 nuclear chromosome segregation; GO:0104004 cellular response to environmental stimulus; GO:0140014 mitotic nuclear division; GO:0198738 cell-cell signaling by wnt; GO:1900087 positive regulation of G1/S transition of mitotic cell cycle; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901654 response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902808 positive regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903608 protein localization to cytoplasmic stress granule; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:1905516 positive regulation of fertilization; GO:2000026 regulation of multicellular organismal development; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005829 cytosol; GO:0010494 cytoplasmic stress granule; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016442 RISC complex; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0019867 outer membrane; GO:0030141 secretory granule; GO:0031090 organelle membrane; GO:0031332 RNAi effector complex; GO:0031410 cytoplasmic vesicle; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0043025 neuronal cell body; GO:0043186 P granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045495 pole plasm; GO:0060205 cytoplasmic vesicle lumen; GO:0060293 germ plasm; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003723 RNA binding; GO:0003724 RNA helicase activity; GO:0003725 double-stranded RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0008134 transcription factor binding; GO:0008143 poly(A) binding; GO:0008186 ATP-dependent activity"," acting on RNA; GO:0008190 eukaryotic initiation factor 4E binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019207 kinase regulator activity; GO:0019209 kinase activator activity; GO:0019887 protein kinase regulator activity; GO:0030234 enzyme regulator activity; GO:0030295 protein kinase activator activity; GO:0031369 translation initiation factor binding; GO:0033592 RNA strand annealing activity; GO:0035613 RNA stem-loop binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043021 ribonucleoprotein complex binding; GO:0043024 ribosomal small subunit binding; GO:0043273 CTPase activity; GO:0043539 protein serine/threonine kinase activator activity; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0048027 mRNA 5'-UTR binding; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:0140097 catalytic activity"," acting on DNA; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF00270; PF00271","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain","A","KOG0335","ATP-dependent RNA helicase","WP3865 NOVEL INTRACELLULAR COMPONENTS OF RIGILIKE RECEPTOR RLR PATHWAY","http://www.wikipathways.org/instance/WP3865_r106524"]
["O15525","Transcription factor MafG OS=Homo sapiens OX=9606 GN=MAFG PE=1 SV=1","MAFG",1.900755705,1.159186E-3,"up",6507.16,8308.24,7545.18,14897.8,14266.6,13337.6,0.601933503,0.768539272,0.697953735,1.378095043,1.319706987,1.23377146,"nucleus","K09037",null,null,"GO:0001701 in utero embryonic development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006873 cellular ion homeostasis; GO:0006885 regulation of pH; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007610 behavior; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009611 response to wounding; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019725 cellular homeostasis; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030534 adult behavior; GO:0030641 regulation of cellular pH; GO:0030856 regulation of epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042592 homeostatic process; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045604 regulation of epidermal cell differentiation; GO:0045682 regulation of epidermis development; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0055067 monovalent inorganic cation homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098771 inorganic ion homeostasis; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0043565 sequence-specific DNA binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;",null,null,"K","KOG4196","bZIP transcription factor MafK","WP4269 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1;WP2884 NRF2 PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP2435 QUERCETIN AND NFKB AP1 INDUCED APOPTOSIS","http://www.wikipathways.org/instance/WP4269_r117715;http://www.wikipathways.org/instance/WP2884_r106658;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP2435_r120750","Transcription factor","R-HSA-109582 Hemostasis;R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9711123;https://reactome.org/PathwayBrowser/#/R-HSA-9755511;https://reactome.org/PathwayBrowser/#/R-HSA-9759194;https://reactome.org/PathwayBrowser/#/R-HSA-983231"]
["O15530","3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1","PDPK1",1.030291728,0.663831864,"nochange",2591.15,2797.38,3163.97,2788.64,3142.43,2880.5,0.895348844,0.966609787,1.093281702,0.963589757,1.085838746,0.995331164,"mitochondria","K06276","PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]","hsa04510 Focal adhesion; hsa04960 Aldosterone-regulated sodium reabsorption; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa04360 Axon guidance; hsa04919 Thyroid hormone signaling pathway; hsa05145 Toxoplasmosis; hsa04210 Apoptosis; hsa05205 Proteoglycans in cancer; hsa04660 T cell receptor signaling pathway; hsa04071 Sphingolipid signaling pathway; hsa04931 Insulin resistance; hsa04152 AMPK signaling pathway; hsa05215 Prostate cancer; hsa04664 Fc epsilon RI signaling pathway; hsa03320 PPAR signaling pathway; hsa04150 mTOR signaling pathway; hsa05223 Non-small cell lung cancer; hsa04140 Autophagy - animal; hsa05213 Endometrial cancer; hsa05231 Choline metabolism in cancer; hsa04722 Neurotrophin signaling pathway; hsa01524 Platinum drug resistance; hsa04151 PI3K-Akt signaling pathway; hsa04910 Insulin signaling pathway; hsa04068 FoxO signaling pathway; hsa05417 Lipid and atherosclerosis",{"$cut":{"chars":21395,"head":"GO:0000003 reproduction; GO:0001558 regulation of cell growth; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001936 regulation of endothelial cell proliferation; GO:0001938 positive regulation of endothelial cell proliferation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002067 glandular epithelial cell differentiation; GO:0002068 glandular epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002218 activation of innate immune response; GO:0002220 innate immune response activating cell surface receptor signaling pathway; GO:0002223 stimulatory C-type lectin receptor signaling pathway; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002703 regulation of leukocyte mediated immunity; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0002886 regulation of myeloid leukocyte mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003309 type B pancreatic cell differentiation; GO:0003323 type B pancreatic cell development; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006970 response to osmotic stress; GO:0006972 hyperosmotic response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007044 cell-substrate junction assembly; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007528 neuromuscular junction development; GO:0007548 sex differentiation; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007610 behavior; GO:0007611 learning or memory; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008284 positive regulation of cell population proliferation; GO:0008286 insulin receptor signaling pathway; GO:0008361 regulation of cell size; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009888 tissue develo"}},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030424 axon; GO:0031410 cytoplasmic vesicle; GO:0031594 neuromuscular junction; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043204 perikaryon; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004676 3-phosphoinositide-dependent protein kinase activity; GO:0005102 signaling receptor binding; GO:0005158 insulin receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0016004 phospholipase activator activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019207 kinase regulator activity; GO:0019209 kinase activator activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0030295 protein kinase activator activity; GO:0043274 phospholipase binding; GO:0044877 protein-containing complex binding; GO:0060229 lipase activator activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF00069; PF14593","PF00069 Protein kinase domain; PF14593 PH domain","T","KOG0592","3-phosphoinositide-dependent protein kinase (PDK1)","WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP2795 CARDIAC HYPERTROPHIC RESPONSE;WP437 EGFEGFR SIGNALING PATHWAY;WP4806 EGFR TYROSINE KINASE INHIBITOR RESISTANCE;WP4155 ENDOMETRIAL CANCER;WP673 ERBB SIGNALING PATHWAY;WP306 FOCAL ADHESION;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP2261 GLIOBLASTOMA SIGNALING PATHWAYS;WP4674 HEAD AND NECK SQUAMOUS CELL CARCINOMA;WP481 INSULIN SIGNALING;WP185 INTEGRINMEDIATED CELL ADHESION;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP3935 LEPTININSULIN SIGNALING OVERLAP;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION;WP4172 PI3KAKT SIGNALING PATHWAY;WP3942 PPAR SIGNALING PATHWAY;WP722 SEROTONIN HTR1 GROUP AND FOS PATHWAY;WP5098 TCELL ACTIVATION SARSCOV2;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY;WP2032 THYROID STIMULATING HORMONE TSH SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP23_r120701;http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP2795_r117670;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP4806_r116801;http://www.wikipathways.org/instance/WP4155_r119086;http://www.wikipathways.org/instance/WP673_r118930;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP2261_r118379;http://www.wikipathways.org/instance/WP4674_r117748;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP185_r116785;http://www.wikipathways.org/instance/WP2332_r120725;http://www.wikipathways.org/instance/WP3935_r118425;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP5072_r115764;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP3942_r106517;http://www.wikipathways.org/instance/WP722_r120570;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP69_r120700;http://www.wikipathways.org/instance/WP2032_r120723;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-109582 Hemostasis;R-HSA-109704 PI3K Cascade;R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission;R-HSA-112315 Transmission across Chemical Synapses;R-HSA-112316 Neuronal System;R-HSA-112399 IRS-mediated signalling;R-HSA-114604 GPVI-mediated activation cascade;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1280218 Adaptive Immune System;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-165158 Activation of AKT2;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194138 Signaling by VEGF;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-212436 Generic Transcription Pathway;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);R-HSA-2428924 IGF1R signaling cascade;R-HSA-2428928 IRS-related events triggered by IGF1R;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-354192 Integrin signaling;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-388841 Costimulation by the CD28 family;R-HSA-389356 CD28 co-stimulation;R-HSA-389357 CD28 dependent PI3K/Akt signaling;R-HSA-392451 G beta:gamma signalling through PI3Kgamma;R-HSA-397795 G-protein beta:gamma signalling;R-HSA-438064 Post NMDA receptor activation events;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;R-HSA-442755 Activation of NMDA receptors and postsynaptic events;R-HSA-444257 RSK activation;R-HSA-5218920 VEGFR2 mediated vascular permeability;R-HSA-5218921 VEGFR2 mediated cell proliferation;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5625740 RHO GTPases activate PKNs;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer;R-HSA-6804757 Regulation of TP53 Degradation;R-HSA-6806003 Regulation of TP53 Expression and Degradation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-74751 Insulin receptor signalling cascade;R-HSA-74752 Signaling by Insulin receptor;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76009 Platelet Aggregation (Plug Formation);R-HSA-8939211 ESR-mediated signaling;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9009391 Extra-nuclear estrogen signaling;R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways"]
["O15533","Tapasin OS=Homo sapiens OX=9606 GN=TAPBP PE=1 SV=2","TAPBP",1.056535339,0.39371299,"nochange",53728.7,49392.4,59409.1,59329.2,54259.6,58130.1,0.96446692,0.886627369,1.066433986,1.064999726,0.973996938,1.043475061,"plasma membrane","K08058","TAPBP; TAP binding protein (tapasin)","hsa05168 Herpes simplex virus 1 infection; hsa04612 Antigen processing and presentation; hsa05170 Human immunodeficiency virus 1 infection; hsa05169 Epstein-Barr virus infection; hsa05163 Human cytomegalovirus infection","GO:0002376 immune system process; GO:0002474 antigen processing and presentation of peptide antigen via MHC class I; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I"," TAP-dependent; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006906 vesicle fusion; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0022607 cellular component assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I; GO:0042886 amide transport; GO:0043603 cellular amide metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048193 Golgi vesicle transport; GO:0048284 organelle fusion; GO:0050789 regulation of biological process; GO:0050822 peptide stabilization; GO:0050823 peptide antigen stabilization; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0061635 regulation of protein complex stability; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090174 organelle membrane fusion; GO:1901564 organonitrogen compound metabolic process; GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030139 endocytic vesicle; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030666 endocytic vesicle membrane; GO:0030670 phagocytic vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042824 MHC class I peptide loading complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045335 phagocytic vesicle; GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098553 lumenal side of endoplasmic reticulum membrane; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003823 antigen binding; GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0015399 primary active transmembrane transporter activity; GO:0015433 ABC-type peptide antigen transporter activity; GO:0015440 ABC-type peptide transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0042287 MHC protein binding; GO:0042288 MHC class I protein binding; GO:0042605 peptide antigen binding; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0042887 amide transmembrane transporter activity; GO:0046977 TAP binding; GO:0046978 TAP1 binding; GO:0046979 TAP2 binding; GO:0051082 unfolded protein binding; GO:1904680 peptide transmembrane transporter activity;","PF07654","PF07654 Immunoglobulin C1-set domain",{"$nulls":6},"R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983170 Antigen Presentation: Folding"," assembly and peptide loading of class I MHC","https://reactome.org/PathwayBrowser/#/R-HSA-1236974;https://reactome.org/PathwayBrowser/#/R-HSA-1236975;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-983169;https://reactome.org/PathwayBrowser/#/R-HSA-983170","ALLOGRAFT REJECTION;INFLAMMATORY RESPONSE;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["O15541","E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1","RNF113A",1.151748845,0.122929249,"nochange",14188,17616.6,16484.4,17673.5,18036.3,19907,0.819280541,1.017263714,0.951885265,1.020549382,1.041499127,1.149521971,"nucleus","K13127",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016074 sno(s)RNA metabolic process; GO:0016567 protein ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034247 snoRNA splicing; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0036211 protein modification process; GO:0043144 sno(s)RNA processing; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045292 mRNA cis splicing"," via spliceosome; GO:0046483 heterocycle metabolic process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1990904 ribonucleoprotein complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0140096 catalytic activity"," acting on a protein;","PF13920","PF13920 Zinc finger"," C3HC4 type (RING finger)","O","KOG1813","Predicted E3 ubiquitin ligase"]
["O15550","Lysine-specific demethylase 6A OS=Homo sapiens OX=9606 GN=KDM6A PE=1 SV=2","KDM6A",0.877882377,0.302921055,"nochange",9140.74,6555.33,8217.35,7435.44,6670.2,6887.53,1.221300482,0.875862095,1.097925716,0.99345419,0.891209954,0.920247563,"extracellular","K11447","UTX; lysine-specific demethylase 6A [EC:1.14.11.68]","hsa05202 Transcriptional misregulation in cancer","GO:0000578 embryonic axis specification; GO:0001701 in utero embryonic development; GO:0001704 formation of primary germ layer; GO:0001707 mesoderm formation; GO:0001708 cell fate specification; GO:0001756 somitogenesis; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0003007 heart morphogenesis; GO:0003008 system process; GO:0003016 respiratory system process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006482 protein demethylation; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007498 mesoderm development; GO:0007507 heart development; GO:0007552 metamorphosis; GO:0007585 respiratory gaseous exchange by respiratory system; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008214 protein dealkylation; GO:0008219 cell death; GO:0008285 negative regulation of cell population proliferation; GO:0008593 regulation of Notch signaling pathway; GO:0009314 response to radiation; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010212 response to ionizing radiation; GO:0010332 response to gamma radiation; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010623 programmed cell death involved in cell development; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0012502 induction of programmed cell death; GO:0014020 primary neural tube formation; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0016331 morphogenesis of embryonic epithelium; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0016577 histone demethylation; GO:0018022 peptidyl-lysine methylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0021915 neural tube development; GO:0022612 gland morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030903 notochord development; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031061 negative regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032525 somite rostral/caudal axis specification; GO:0032870 cellular response to hormone stimulus; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034968 histone lysine methylation; GO:0035070 salivary gland histolysis; GO:0035071 salivary gland cell autophagic cell death; GO:0035072 ecdysone-mediated induction of salivary gland cell autophagic cell death; GO:0035075 response to ecdysone; GO:0035078 induction of programmed cell death by ecdysone; GO:0035081 induction of programmed cell death by hormones; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035264 multicellular organism growth; GO:0035272 exocrine system development; GO:0035282 segmentation; GO:0035295 tube development; GO:0036211 protein modification process; GO:0036314 response to sterol; GO:0036315 cellular response to sterol; GO:0040007 growth; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0043009 chordate embryonic development; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045165 cell fate commitment; GO:0045498 sex comb development; GO:0045746 negative regulation of Notch signaling pathway; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048102 autophagic cell death; GO:0048332 mesoderm morphogenesis; GO:0048333 mesodermal cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048570 notochord morphogenesis; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051568 histone H3-K4 methylation; GO:0051716 cellular response to stimulus; GO:0060033 anatomical structure regression; GO:0060070 canonical Wnt signaling pathway; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0061053 somite development; GO:0061085 regulation of histone H3-K27 methylation; GO:0061086 negative regulation of histone H3-K27 methylation; GO:0065007 biological regulation; GO:0070076 histone lysine demethylation; GO:0070887 cellular response to chemical stimulus; GO:0070988 demethylation; GO:0071214 cellular response to abiotic stimulus; GO:0071310 cellular response to organic substance; GO:0071390 cellular response to ecdysone; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071480 cellular response to gamma radiation; GO:0071495 cellular response to endogenous stimulus; GO:0071557 histone H3-K27 demethylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0104004 cellular response to environmental stimulus; GO:0198738 cell-cell signaling by wnt; GO:1901564 organonitrogen compound metabolic process; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902275 regulation of chromatin organization; GO:1902464 regulation of histone H3-K27 trimethylation; GO:1902465 negative regulation of histone H3-K27 trimethylation; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:1905268 negative regulation of chromatin organization; GO:1990248 regulation of transcription from RNA polymerase II promoter in response to DNA damage; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005705 polytene chromosome interband; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044666 MLL3/4 complex; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0031490 chromatin DNA binding; GO:0032451 demethylase activity; GO:0032452 histone demethylase activity; GO:0042802 identical protein binding; GO:0043565 sequence-specific DNA binding; GO:0051427 hormone receptor binding; GO:0071558 histone H3-tri/di-methyl-lysine-27 demethylase activity; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding; GO:1990841 promoter-specific chromatin binding;","PF02373","PF02373 JmjC domain"," hydroxylase","R","KOG1246","DNA-binding protein jumonji/RBP2/SMCY"," contains JmjC domain","WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP2857 MESODERMAL COMMITMENT PATHWAY;WP3651 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA","http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP3651_r116547","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-3214842 HDMs demethylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-3214842;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5617472;https://reactome.org/PathwayBrowser/#/R-HSA-5619507"]
["O15554","Intermediate conductance calcium-activated potassium channel protein 4 OS=Homo sapiens OX=9606 GN=KCNN4 PE=1 SV=1","KCNN4",0.862735027,0.451045561,"nochange",7680.48,9341.28,12201.5,6841.56,9022.77,9347.6,0.846564144,1.029622198,1.344883705,0.754096018,0.994515129,1.030318807,"plasma membrane","K04945","KCNN4; potassium intermediate/small conductance calcium-activated channel subfamily N member 4","hsa04974 Protein digestion and absorption; hsa04929 GnRH secretion; hsa04911 Insulin secretion; hsa04970 Salivary secretion","GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003008 system process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006813 potassium ion transport; GO:0006816 calcium ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006884 cell volume homeostasis; GO:0006950 response to stress; GO:0006952 defense response; GO:0007586 digestion; GO:0007589 body fluid secretion; GO:0008361 regulation of cell size; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010876 lipid localization; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015914 phospholipid transport; GO:0016043 cellular component organization; GO:0019725 cellular homeostasis; GO:0022600 digestive system process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030001 metal ion transport; GO:0030322 stabilization of membrane potential; GO:0032501 multicellular organismal process; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032941 secretion by tissue; GO:0033036 macromolecule localization; GO:0034204 lipid translocation; GO:0034220 ion transmembrane transport; GO:0042391 regulation of membrane potential; GO:0042592 homeostatic process; GO:0045332 phospholipid translocation; GO:0046541 saliva secretion; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050854 regulation of antigen receptor-mediated signaling pathway; GO:0050856 regulation of T cell receptor signaling pathway; GO:0050857 positive regulation of antigen receptor-mediated signaling pathway; GO:0050862 positive regulation of T cell receptor signaling pathway; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0071702 organic substance transport; GO:0071805 potassium ion transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0097035 regulation of membrane lipid distribution; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904951 positive regulation of establishment of protein localization;","GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0008076 voltage-gated potassium channel complex; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0034702 ion channel complex; GO:0034703 cation channel complex; GO:0034705 potassium channel complex; GO:0036477 somatodendritic compartment; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0044297 cell body; GO:0045121 membrane raft; GO:0045177 apical part of cell; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098857 membrane microdomain; GO:1902495 transmembrane transporter complex; GO:1990351 transporter complex;","GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005227 calcium activated cation channel activity; GO:0005261 cation channel activity; GO:0005267 potassium channel activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015079 potassium ion transmembrane transporter activity; GO:0015267 channel activity; GO:0015269 calcium-activated potassium channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0016286 small conductance calcium-activated potassium channel activity; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0022803 passive transmembrane transporter activity; GO:0022836 gated channel activity; GO:0022839 ion gated channel activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0022894 Intermediate conductance calcium-activated potassium channel activity; GO:0046873 metal ion transmembrane transporter activity;",null,null,"P","KOG3684","Ca2+-activated K+ channel proteins (intermediate/small conductance classes)",{"$nulls":3},"R-HSA-112316 Neuronal System;R-HSA-1296052 Ca2+ activated K+ channels;R-HSA-1296071 Potassium Channels","https://reactome.org/PathwayBrowser/#/R-HSA-112316;https://reactome.org/PathwayBrowser/#/R-HSA-1296052;https://reactome.org/PathwayBrowser/#/R-HSA-1296071","KRAS SIGNALING UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP"]
["O43143","ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2","DHX15",1.424733822,{"v":1.19393e-05,"d":"1.19E-05"},"up",197400,189990,195302,276961,279914,273306,0.838291906,0.806824109,0.8293824,1.176160915,1.18870132,1.16063935,"nucleus","K12820","DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 [EC:3.6.4.13]","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016072 rRNA metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:1900744 regulation of p38MAPK cascade; GO:1900745 positive regulation of p38MAPK cascade; GO:1901360 organic cyclic compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005689 U12-type spliceosomal complex; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003724 RNA helicase activity; GO:0003725 double-stranded RNA binding; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0008186 ATP-dependent activity"," acting on RNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF00270; PF00271; PF04408; PF07717","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain; PF04408 Helicase associated domain (HA2); PF07717 Oligonucleotide/oligosaccharide-binding (OB)-fold","A","KOG0925","mRNA splicing factor ATP-dependent RNA helicase","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O43148","mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1","RNMT",1.41207225,{"v":6.37529e-05,"d":"6.38E-05"},"up",27709,28281.3,27574.9,40667.4,39130.3,38202.4,0.824814589,0.841850259,0.82082283,1.210547649,1.16479275,1.137171924,"nucleus","K00565","RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]","hsa03015 mRNA surveillance pathway","GO:0001510 RNA methylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009451 RNA modification; GO:0009452 7-methylguanosine RNA capping; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016556 mRNA modification; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0032259 methylation; GO:0032774 RNA biosynthetic process; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036260 RNA capping; GO:0036265 RNA (guanine-N7)-methylation; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:0080009 mRNA methylation; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0106005 RNA 5'-cap (guanine-N7)-methylation; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005845 mRNA cap binding complex; GO:0031533 mRNA cap methyltransferase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034518 RNA cap binding complex; GO:0034708 methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043235 receptor complex; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004482 mRNA (guanine-N7-)-methyltransferase activity; GO:0005488 binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008174 mRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG1975","mRNA cap methyltransferase","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167172 Transcription of the HIV genome;R-HSA-5663205 Infectious disease;R-HSA-72086 mRNA Capping;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-167160;https://reactome.org/PathwayBrowser/#/R-HSA-167172;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-72086;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-77075;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6","ZZEF1",1.07160008,0.126879558,"nochange",6270.01,6335.74,6406.24,6573.45,6528.92,7270.88,0.955181687,0.965195083,0.975935147,1.001408142,0.994624382,1.107655558,"plasma membrane",{"$nulls":6},"PF00569","PF00569 Zinc finger"," ZZ type","S","KOG1426","FOG: RCC1 domain"]
["O43156","TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3","TTI1",1.085799417,0.454774965,"nochange",11980.2,11308.6,14669.5,15569.9,12858.1,12787.1,0.907895834,0.856999952,1.111699131,1.17993417,0.974425754,0.969045159,"cytoplasm","K20403","TTI1; TELO2-interacting protein 1","hsa04150 mTOR signaling pathway","GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0032006 regulation of TOR signaling; GO:0032502 developmental process; GO:0045165 cell fate commitment; GO:0045168 cell-cell signaling involved in cell fate commitment; GO:0046331 lateral inhibition; GO:0048583 regulation of response to stimulus; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation; GO:1902531 regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0031931 TORC1 complex; GO:0031932 TORC2 complex; GO:0032991 protein-containing complex; GO:0038201 TOR complex;",{"$nulls":3},"S","KOG4524","Uncharacterized conserved protein","WP4549 FRAGILE X SYNDROME;WP5087 MALIGNANT PLEURAL MESOTHELIOMA","http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP5087_r120373"]
["O43159","Ribosomal RNA-processing protein 8 OS=Homo sapiens OX=9606 GN=RRP8 PE=1 SV=2","RRP8",0.577235082,4.293865E-3,"down",17214.6,16820.7,18005.3,8711.79,11896.8,9431.07,1.258373207,1.229579438,1.316172731,0.636824737,0.869646368,0.689403518,"nucleus","K14850",null,null,"GO:0000183 rDNA heterochromatin assembly; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032259 methylation; GO:0033554 cellular response to stress; GO:0035556 intracellular signal transduction; GO:0040029 regulation of gene expression"," epigenetic; GO:0042149 cellular response to glucose starvation; GO:0042594 response to starvation; GO:0045787 positive regulation of cell cycle; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046015 regulation of transcription by glucose; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071496 cellular response to external stimulus; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005677 chromatin silencing complex; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0017053 transcription repressor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033553 rDNA heterochromatin; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008168 methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding;",null,null,"A","KOG3045","Predicted RNA methylase involved in rRNA processing",{"$nulls":3},"R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-427359 SIRT1 negatively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-427359;https://reactome.org/PathwayBrowser/#/R-HSA-5250941;https://reactome.org/PathwayBrowser/#/R-HSA-74160","P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O43164","E3 ubiquitin-protein ligase Praja-2 OS=Homo sapiens OX=9606 GN=PJA2 PE=1 SV=4","PJA2",1.076393418,0.629541848,"nochange",1937.73,3150.38,2026.77,2201.68,2520.28,2936.45,0.786986514,1.279490215,0.823149075,0.894186738,1.023582425,1.192605032,"nucleus","K10634",null,null,"GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002274 myeloid leukocyte activation; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008152 metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010738 regulation of protein kinase A signaling; GO:0016567 protein ubiquitination; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0034121 regulation of toll-like receptor signaling pathway; GO:0034123 positive regulation of toll-like receptor signaling pathway; GO:0034135 regulation of toll-like receptor 2 signaling pathway; GO:0034137 positive regulation of toll-like receptor 2 signaling pathway; GO:0036211 protein modification process; GO:0042116 macrophage activation; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045321 leukocyte activation; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:1900744 regulation of p38MAPK cascade; GO:1900745 positive regulation of p38MAPK cascade; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045111 intermediate filament cytoskeleton; GO:0071944 cell periphery;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0034236 protein kinase A catalytic subunit binding; GO:0034237 protein kinase A regulatory subunit binding; GO:0051018 protein kinase A binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF13639","PF13639 Ring finger domain","O","KOG0800","FOG: Predicted E3 ubiquitin ligase",{"$nulls":3},"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["O43166","Signal-induced proliferation-associated 1-like protein 1 OS=Homo sapiens OX=9606 GN=SIPA1L1 PE=1 SV=4","SIPA1L1",1.313607005,0.154305394,"nochange",4575.17,3514.24,5799.98,5693.31,7042.6,5509.29,0.854251447,0.656160231,1.082941466,1.06302461,1.314956874,1.028665373,"nucleus","K17701","SIPA1L1; signal-induced proliferation-associated 1 like protein 1","hsa04015 Rap1 signaling pathway","GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0016043 cellular component organization; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0031344 regulation of cell projection organization; GO:0031532 actin cytoskeleton reorganization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0048013 ephrin receptor signaling pathway; GO:0048167 regulation of synaptic plasticity; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060998 regulation of dendritic spine development; GO:0061001 regulation of dendritic spine morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0090630 activation of GTPase activity; GO:0099175 regulation of postsynapse organization; GO:0099177 regulation of trans-synaptic signaling; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0014069 postsynaptic density; GO:0030425 dendrite; GO:0032279 asymmetric synapse; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0044309 neuron spine; GO:0045202 synapse; GO:0097447 dendritic tree; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection;","GO:0003779 actin binding; GO:0005096 GTPase activator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044877 protein-containing complex binding; GO:0046875 ephrin receptor binding; GO:0051015 actin filament binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;",null,null,"T","KOG3686","Rap1-GTPase-activating protein (Rap1GAP)",{"$nulls":3},"R-HSA-112316 Neuronal System;R-HSA-6794361 Neurexins and neuroligins;R-HSA-6794362 Protein-protein interactions at synapses","https://reactome.org/PathwayBrowser/#/R-HSA-112316;https://reactome.org/PathwayBrowser/#/R-HSA-6794361;https://reactome.org/PathwayBrowser/#/R-HSA-6794362","UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["O43169","Cytochrome b5 type B OS=Homo sapiens OX=9606 GN=CYB5B PE=1 SV=3","CYB5B",1.088670553,0.181729665,"nochange",44996.2,48828.9,42010.3,49726.6,51650.4,46503,0.951577532,1.032631292,0.888431858,1.051615809,1.092300242,0.983443267,"cytoplasm","K23490",null,null,"GO:0002682 regulation of immune system process; GO:0006091 generation of precursor metabolites and energy; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0022900 electron transport chain; GO:0035206 regulation of hemocyte proliferation; GO:0042127 regulation of cell population proliferation; GO:0043085 positive regulation of catalytic activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0045595 regulation of cell differentiation; GO:0045610 regulation of hemocyte differentiation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051239 regulation of multicellular organismal process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0016020 membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0098588 bounding membrane of organelle;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0008047 enzyme activator activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0020037 heme binding; GO:0030234 enzyme regulator activity; GO:0046906 tetrapyrrole binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901363 heterocyclic compound binding;","PF00173","PF00173 Cytochrome b5-like Heme/Steroid binding domain","C","KOG0537","Cytochrome b5","WP43 OXIDATION BY CYTOCHROME P450","http://www.wikipathways.org/instance/WP43_r119227",null,"R-HSA-1430728 Metabolism;R-HSA-211859 Biological oxidations;R-HSA-211945 Phase I - Functionalization of compounds","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-211945","MTORC1 SIGNALING;UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["O43172","U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2","PRPF4",1.487574604,0.000146807,"up",41155.9,39658.8,39688.5,58336.2,58107.3,62814,0.823775098,0.793809195,0.794403669,1.1676554,1.163073745,1.257282893,"nucleus","K12662","PRPF4; U4/U6 small nuclear ribonucleoprotein PRP4","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0015030 Cajal body; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0046540 U4/U6 x U5 tri-snRNP complex; GO:0070013 intracellular organelle lumen; GO:0071001 U4/U6 snRNP; GO:0071005 U2-type precatalytic spliceosome; GO:0071011 precatalytic spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0097526 spliceosomal tri-snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0017069 snRNA binding; GO:0017070 U6 snRNA binding; GO:0030621 U4 snRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF08799","PF08799 pre-mRNA processing factor 4 (PRP4) like","A","KOG0272","U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160","Transcription factor","R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O43175","D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4","PHGDH",0.833040551,2.5608E-4,"down",133700,136172,138281,115402,110993,113613,1.072229106,1.092053716,1.108967188,0.92548529,0.89012659,0.911138111,"cytoplasm","K00058","serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]","hsa00260 Glycine"," serine and threonine metabolism; hsa00270 Cysteine and methionine metabolism; hsa01200 Carbon metabolism; hsa01230 Biosynthesis of amino acids; hsa01100 Metabolic pathways","GO:0001505 regulation of neurotransmitter levels; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006520 cellular amino acid metabolic process; GO:0006541 glutamine metabolic process; GO:0006544 glycine metabolic process; GO:0006563 L-serine metabolic process; GO:0006564 L-serine biosynthetic process; GO:0006566 threonine metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0008652 cellular amino acid biosynthetic process; GO:0009058 biosynthetic process; GO:0009064 glutamine family amino acid metabolic process; GO:0009066 aspartate family amino acid metabolic process; GO:0009069 serine family amino acid metabolic process; GO:0009070 serine family amino acid biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009448 gamma-aminobutyric acid metabolic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010468 regulation of gene expression; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019530 taurine metabolic process; GO:0019694 alkanesulfonate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0021510 spinal cord development; GO:0021782 glial cell development; GO:0021915 neural tube development; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022900 electron transport chain; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0035295 tube development; GO:0042063 gliogenesis; GO:0042133 neurotransmitter metabolic process; GO:0042221 response to chemical; GO:0043009 chordate embryonic development; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070314 G1 to G0 transition; GO:0070887 cellular response to chemical stimulus; GO:0071466 cellular response to xenobiotic stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0120036 plasma membrane bounded cell projection organization; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901607 alpha-amino acid biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043209 myelin sheath;","GO:0003824 catalytic activity; GO:0004617 phosphoglycerate dehydrogenase activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor;","PF19304","PF19304 D-3-phosphoglycerate dehydrogenase intervening domain","E","KOG0068","D-3-phosphoglycerate dehydrogenase"," D-isomer-specific 2-hydroxy acid dehydrogenase superfamily","WP4018 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS;WP5083 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING;WP4688 SERINE METABOLISM;WP2525 TRANSSULFURATION AND ONECARBON METABOLISM","http://www.wikipathways.org/instance/WP4018_r117168;http://www.wikipathways.org/instance/WP5083_r120385;http://www.wikipathways.org/instance/WP4688_r120418;http://www.wikipathways.org/instance/WP2525_r116582",null,"R-HSA-1430728 Metabolism;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-977347 Serine biosynthesis","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-977347","MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4"," mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS4 PE=1 SV=1","NDUFS4",1.094702264,0.307920825,"nochange",9817.32,8764.4,8648.78,9061.41,9547.08,11200.8,1.032681221,0.921924853,0.909762816,0.953167254,1.004254749,1.178209106,"mitochondria","K03937","NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0001932 regulation of protein phosphorylation; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010257 NADH dehydrogenase complex assembly; GO:0010876 lipid localization; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019915 lipid storage; GO:0019932 second-messenger-mediated signaling; GO:0019933 cAMP-mediated signaling; GO:0019935 cyclic-nucleotide-mediated signaling; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033036 macromolecule localization; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0035556 intracellular signal transduction; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0046683 response to organophosphorus; GO:0048145 regulation of fibroblast proliferation; GO:0048146 positive regulation of fibroblast proliferation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051235 maintenance of location; GO:0051246 regulation of protein metabolic process; GO:0051591 response to cAMP; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0072593 reactive oxygen species metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045271 respiratory chain complex I; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0050136 NADH dehydrogenase (quinone) activity;",null,null,"C","KOG3389","NADH:ubiquinone oxidoreductase"," NDUFS4/18 kDa subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O43182","Rho GTPase-activating protein 6 OS=Homo sapiens OX=9606 GN=ARHGAP6 PE=1 SV=3","ARHGAP6",1.076082089,0.100478715,"nochange",16198.9,15309.5,14490.6,16915.3,16154.8,16428.6,1.017756449,0.961876569,0.910426115,1.062766957,1.014985701,1.03218821,"nucleus","K20631",null,null,"GO:0001952 regulation of cell-matrix adhesion; GO:0001953 negative regulation of cell-matrix adhesion; GO:0006950 response to stress; GO:0006952 defense response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007044 cell-substrate junction assembly; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007202 activation of phospholipase C activity; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007266 Rho protein signal transduction; GO:0008154 actin polymerization or depolymerization; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009620 response to fungus; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010517 regulation of phospholipase activity; GO:0010518 positive regulation of phospholipase activity; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010810 regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0010863 positive regulation of phospholipase C activity; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030041 actin filament polymerization; GO:0030155 regulation of cell adhesion; GO:0031589 cell-substrate adhesion; GO:0032231 regulation of actin filament bundle assembly; GO:0032232 negative regulation of actin filament bundle assembly; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034332 adherens junction organization; GO:0034333 adherens junction assembly; GO:0035556 intracellular signal transduction; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043207 response to external biotic stimulus; GO:0043547 positive regulation of GTPase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045216 cell-cell junction organization; GO:0048041 focal adhesion assembly; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050832 defense response to fungus; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051258 protein polymerization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051497 negative regulation of stress fiber assembly; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051893 regulation of focal adhesion assembly; GO:0051895 negative regulation of focal adhesion assembly; GO:0060191 regulation of lipase activity; GO:0060193 positive regulation of lipase activity; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0090109 regulation of cell-substrate junction assembly; GO:0097435 supramolecular fiber organization; GO:0098542 defense response to other organism; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:1900274 regulation of phospholipase C activity; GO:1901888 regulation of cell junction assembly; GO:1901889 negative regulation of cell junction assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1903391 regulation of adherens junction organization; GO:1903392 negative regulation of adherens junction organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0015629 actin cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0016004 phospholipase activator activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030674 protein-macromolecule adaptor activity; GO:0030695 GTPase regulator activity; GO:0035591 signaling adaptor activity; GO:0043274 phospholipase binding; GO:0060090 molecular adaptor activity; GO:0060229 lipase activator activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00620","PF00620 RhoGAP domain","TZ","KOG2710","Rho GTPase-activating protein",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O43189","PHD finger protein 1 OS=Homo sapiens OX=9606 GN=PHF1 PE=1 SV=3","PHF1",1.690792105,0.033582921,"nochange",2886.08,4906.3,4683.11,7108.44,7416.67,6568.35,0.515848128,0.876935382,0.83704316,1.270538399,1.325630382,1.174004549,"nucleus","K11467",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031061 negative regulation of histone methylation; GO:0031062 positive regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033554 cellular response to stress; GO:0040029 regulation of gene expression"," epigenetic; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061085 regulation of histone H3-K27 methylation; GO:0061086 negative regulation of histone H3-K27 methylation; GO:0061087 positive regulation of histone H3-K27 methylation; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902275 regulation of chromatin organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1905268 negative regulation of chromatin organization; GO:1905269 positive regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0035861 site of double-strand break; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090734 site of DNA damage;","GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding; GO:0140110 transcription regulator activity;","PF18104; PF00628; PF14061","PF18104 Jumonji domain-containing protein 2A Tudor domain; PF00628 PHD-finger; PF14061 Polycomb-like MTF2 factor 2","R","KOG4323","Polycomb-like PHD Zn-finger protein",{"$nulls":3},"R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-212300 PRC2 methylates histones and DNA;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-212300;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["O43237","Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1","DYNC1LI2",1.207908676,0.044335196,"nochange",7676.15,8986.42,8611.7,10860.1,10351.9,9317.01,0.825343958,0.966224924,0.92593482,1.16768405,1.113042101,1.001770147,"cytoplasm","K10416","DYNC1LI; dynein cytoplasmic 1 light intermediate chain","hsa05132 Salmonella infection; hsa04145 Phagosome; hsa04962 Vasopressin-regulated water reabsorption","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0002376 immune system process; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0003006 developmental process involved in reproduction; GO:0006403 RNA localization; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0008088 axo-dendritic transport; GO:0008090 retrograde axonal transport; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010970 transport along microtubule; GO:0010975 regulation of neuron projection development; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016358 dendrite development; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031175 neuron projection development; GO:0031344 regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0042221 response to chemical; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0046907 intracellular transport; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048193 Golgi vesicle transport; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050767 regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051239 regulation of multicellular organismal process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0060284 regulation of cell development; GO:0061564 axon development; GO:0061842 microtubule organizing center localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0098930 axonal transport; GO:0099111 microtubule-based transport; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1990089 response to nerve growth factor; GO:1990090 cellular response to nerve growth factor stimulus; GO:2000026 regulation of multicellular organismal development;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005868 cytoplasmic dynein complex; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0015630 microtubule cytoskeleton; GO:0030286 dynein complex; GO:0032991 protein-containing complex; GO:0035371 microtubule plus-end; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0098687 chromosomal region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1990752 microtubule end;","GO:0005488 binding; GO:0005515 protein binding; GO:0045504 dynein heavy chain binding;",null,null,"N","KOG3905","Dynein light intermediate chain","WP4532 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN;WP5085 VASOPRESSINREGULATED WATER REABSORPTION","http://www.wikipathways.org/instance/WP4532_r103287;http://www.wikipathways.org/instance/WP5085_r119785",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1632852 Macroautophagy;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-2132295 MHC class II antigen presentation;R-HSA-2262752 Cellular responses to stress;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-8953897 Cellular responses to stimuli;R-HSA-948021 Transport to the Golgi and subsequent modification;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9612973 Autophagy;R-HSA-9646399 Aggrephagy;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9663891 Selective autophagy;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3"]
["O43242","26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2","PSMD3",1.217996983,0.000652687,"up",102783,99580.4,96202.2,121080,122860,119712,0.931261869,0.902244821,0.871636755,1.097041214,1.113168844,1.084646497,"cytoplasm","K03033","PSMD3; 26S proteasome regulatory subunit N3","hsa05017 Spinocerebellar ataxia; hsa05016 Huntington disease; hsa03050 Proteasome; hsa05169 Epstein-Barr virus infection; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0016192 vesicle-mediated transport; GO:0016579 protein deubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0032940 secretion by cell; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000502 proteasome complex; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005838 proteasome regulatory particle; GO:0008541 proteasome regulatory particle"," lid subcomplex; GO:0012505 endomembrane system; GO:0022624 proteasome accessory complex; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1902494 catalytic complex; GO:1904813 ficolin-1-rich granule lumen; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding;","PF01399","PF01399 PCI domain","O","KOG2581","26S proteasome regulatory complex"," subunit RPN3/PSMD3","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY;WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP2359_r119918;http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O43251","RNA binding protein fox-1 homolog 2 OS=Homo sapiens OX=9606 GN=RBFOX2 PE=1 SV=3","RBFOX2",1.245617244,0.016206387,"nochange",11207.8,11781.4,10910.7,15139.2,12785.3,14301.8,0.883359474,0.928568614,0.859943094,1.193218629,1.00769249,1.127217699,"nucleus","K14946",null,null,"GO:0000003 reproduction; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002682 regulation of immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007530 sex determination; GO:0007538 primary sex determination; GO:0007549 dosage compensation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007617 mating behavior; GO:0007618 mating; GO:0008152 metabolic process; GO:0008543 fibroblast growth factor receptor signaling pathway; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010724 regulation of definitive erythrocyte differentiation; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0017148 negative regulation of translation; GO:0019098 reproductive behavior; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021535 cell migration in hindbrain; GO:0021932 hindbrain radial glia guided cell migration; GO:0021942 radial glia guided migration of Purkinje cell; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030520 intracellular estrogen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0030706 germarium-derived oocyte differentiation; GO:0030902 hindbrain development; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033993 response to lipid; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040011 locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042464 dosage compensation by hypoactivation of X chromosome; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045646 regulation of erythrocyte differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050885 neuromuscular process controlling balance; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071774 response to fibroblast growth factor; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901360 organic cyclic compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008143 poly(A) binding; GO:0008187 poly-pyrimidine tract binding; GO:0008266 poly(U) RNA binding; GO:0034046 poly(G) binding; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","R","KOG0125","Ataxin 2-binding protein (RRM superfamily)","WP4842 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT","http://www.wikipathways.org/instance/WP4842_r119114","Transcription factor","R-HSA-162582 Signal Transduction;R-HSA-190236 Signaling by FGFR;R-HSA-5654738 Signaling by FGFR2;R-HSA-6803529 FGFR2 alternative splicing;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-190236;https://reactome.org/PathwayBrowser/#/R-HSA-5654738;https://reactome.org/PathwayBrowser/#/R-HSA-6803529;https://reactome.org/PathwayBrowser/#/R-HSA-9006934"]
["O43252","Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2","PAPSS1",1.270777515,0.000708032,"up",37287.4,38124.2,38350.8,46043.5,48570.7,49952.5,0.866044127,0.885479801,0.890742855,1.069414944,1.128112164,1.160206109,"nucleus","K13811","PAPSS; 3'-phosphoadenosine 5'-phosphosulfate synthase [EC:2.7.7.4 2.7.1.25]","hsa00450 Selenocompound metabolism; hsa00920 Sulfur metabolism; hsa00230 Purine metabolism; hsa01100 Metabolic pathways","GO:0000103 sulfate assimilation; GO:0001501 skeletal system development; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034035 purine ribonucleoside bisphosphate metabolic process; GO:0034036 purine ribonucleoside bisphosphate biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process; GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0009336 sulfate adenylyltransferase complex (ATP); GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:1902494 catalytic complex; GO:1902503 adenylyltransferase complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004020 adenylylsulfate kinase activity; GO:0004779 sulfate adenylyltransferase activity; GO:0004781 sulfate adenylyltransferase (ATP) activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016779 nucleotidyltransferase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0070566 adenylyltransferase activity;","PF01583; PF14306; PF01747","PF01583 Adenylylsulphate kinase; PF14306 PUA-like domain; PF01747 ATP-sulfurylase","F","KOG4238","Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase","WP692 SULFATION BIOTRANSFORMATION REACTION","http://www.wikipathways.org/instance/WP692_r117833",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156584 Cytosolic sulfonation of small molecules;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-1643685 Disease;R-HSA-174362 Transport and synthesis of PAPS;R-HSA-211859 Biological oxidations;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-6802952 Signaling by BRAF and RAF1 fusions;R-HSA-6802957 Oncogenic MAPK signaling;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156584;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-174362;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-2408522;https://reactome.org/PathwayBrowser/#/R-HSA-2408550;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-6802952;https://reactome.org/PathwayBrowser/#/R-HSA-6802957;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["O43264","Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3","ZW10",0.791777152,0.014433101,"nochange",20857.8,21199.9,19903.8,17174.5,17242.7,14642.5,1.127233357,1.145721718,1.075675637,0.928174078,0.931859861,0.791335349,"cytoplasm","K11578",null,null,"GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000075 cell cycle checkpoint signaling; GO:0000132 establishment of mitotic spindle orientation; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0000910 cytokinesis; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007030 Golgi organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007060 male meiosis chromosome segregation; GO:0007080 mitotic metaphase plate congression; GO:0007088 regulation of mitotic nuclear division; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007094 mitotic spindle assembly checkpoint signaling; GO:0007096 regulation of exit from mitosis; GO:0007107 membrane addition at site of cytokinesis; GO:0007112 male meiosis cytokinesis; GO:0007140 male meiotic nuclear division; GO:0007163 establishment or maintenance of cell polarity; GO:0007276 gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010324 membrane invagination; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030010 establishment of cell polarity; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0031577 spindle checkpoint signaling; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0032506 cytokinetic process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0033206 meiotic cytokinesis; GO:0033365 protein localization to organelle; GO:0034501 protein localization to kinetochore; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0036090 cleavage furrow ingression; GO:0040001 establishment of mitotic spindle localization; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045132 meiotic chromosome segregation; GO:0045786 negative regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045841 negative regulation of mitotic metaphase/anaphase transition; GO:0045930 negative regulation of mitotic cell cycle; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0050000 chromosome localization; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051276 chromosome organization; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051301 cell division; GO:0051303 establishment of chromosome localization; GO:0051310 metaphase plate congression; GO:0051321 meiotic cell cycle; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0061024 membrane organization; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071173 spindle assembly checkpoint signaling; GO:0071174 mitotic spindle checkpoint signaling; GO:0071459 protein localization to chromosome"," centromeric region; GO:0071840 cellular component organization or biogenesis; GO:0098813 nuclear chromosome segregation; GO:0099024 plasma membrane invagination; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001251 negative regulation of chromosome organization;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0000922 spindle pole; GO:0000940 outer kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005819 spindle; GO:0005828 kinetochore microtubule; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0036063 acroblast; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0051233 spindle midzone; GO:0070939 Dsl1/NZR complex; GO:0098687 chromosomal region; GO:0098791 Golgi apparatus subcompartment; GO:0099023 vesicle tethering complex; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:1990423 RZZ complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019237 centromeric DNA binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0043565 sequence-specific DNA binding; GO:0051020 GTPase binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;",null,null,"D","KOG2163","Centromere/kinetochore protein zw10 involved in mitotic chromosome segregation",{"$nulls":3},"R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199991 Membrane Trafficking;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","E2F TARGETS;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O43290","U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1","SART1",1.010159646,0.804315101,"nochange",63481.5,61035.6,60617.3,66385.4,60422.9,60207,1.023483292,0.984049161,0.977305101,1.070301548,0.974170878,0.970690021,"nucleus","K11984","SART1; U4/U6.U5 tri-snRNP-associated protein 1","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0000481 maturation of 5S rRNA; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016072 rRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030155 regulation of cell adhesion; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045292 mRNA cis splicing"," via spliceosome; GO:0045580 regulation of T cell differentiation; GO:0045582 positive regulation of T cell differentiation; GO:0045583 regulation of cytotoxic T cell differentiation; GO:0045585 positive regulation of cytotoxic T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045621 positive regulation of lymphocyte differentiation; GO:0045785 positive regulation of cell adhesion; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0051094 positive regulation of developmental process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0015030 Cajal body; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0046540 U4/U6 x U5 tri-snRNP complex; GO:0070013 intracellular organelle lumen; GO:0071005 U2-type precatalytic spliceosome; GO:0071011 precatalytic spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0097526 spliceosomal tri-snRNP complex; GO:0120114 Sm-like protein family complex; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG2217","U4/U6.U5 snRNP associated protein",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O43291","Kunitz-type protease inhibitor 2 OS=Homo sapiens OX=9606 GN=SPINT2 PE=1 SV=2","SPINT2",0.885981296,0.17825831,"nochange",6010.64,4952.59,5671.76,5359.89,4597.52,4780.88,1.149508116,0.947160769,1.084698827,1.025055079,0.879255213,0.914321996,"extracellular","K23421",null,null,"GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001701 in utero embryonic development; GO:0001763 morphogenesis of a branching structure; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001890 placenta development; GO:0001892 embryonic placenta development; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0003382 epithelial cell morphogenesis; GO:0007162 negative regulation of cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008285 negative regulation of cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010466 negative regulation of peptidase activity; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010951 negative regulation of endopeptidase activity; GO:0014020 primary neural tube formation; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0019222 regulation of metabolic process; GO:0021915 neural tube development; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030162 regulation of proteolysis; GO:0030198 extracellular matrix organization; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042127 regulation of cell population proliferation; GO:0043009 chordate embryonic development; GO:0043062 extracellular structure organization; GO:0043086 negative regulation of catalytic activity; GO:0044092 negative regulation of molecular function; GO:0045861 negative regulation of proteolysis; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048568 embryonic organ development; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0060669 embryonic placenta morphogenesis; GO:0060670 branching involved in labyrinthine layer morphogenesis; GO:0060671 epithelial cell differentiation involved in embryonic placenta development; GO:0060672 epithelial cell morphogenesis involved in placental branching; GO:0060706 cell differentiation involved in embryonic placenta development; GO:0060711 labyrinthine layer development; GO:0060713 labyrinthine layer morphogenesis; GO:0061138 morphogenesis of a branching epithelium; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071711 basement membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0072175 epithelial tube formation; GO:0080090 regulation of primary metabolic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0071944 cell periphery;","GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0004867 serine-type endopeptidase inhibitor activity; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0098772 molecular function regulator;","PF00014","PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain","O","KOG4295","Serine proteinase inhibitor (KU family)",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-6806834 Signaling by MET;R-HSA-6806942 MET Receptor Activation;R-HSA-8852405 Signaling by MST1;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-6806834;https://reactome.org/PathwayBrowser/#/R-HSA-6806942;https://reactome.org/PathwayBrowser/#/R-HSA-8852405;https://reactome.org/PathwayBrowser/#/R-HSA-9006934","XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["O43292","Glycosylphosphatidylinositol anchor attachment 1 protein OS=Homo sapiens OX=9606 GN=GPAA1 PE=1 SV=3","GPAA1",0.86934607,0.055610216,"nochange",19424,18884.9,16944.7,16376.9,15033.6,16624,1.128339083,1.097022794,0.984316683,0.951333213,0.87330099,0.965687238,"plasma membrane","K05289","GAA1; GPI-anchor transamidase subunit GAA1","hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; hsa01100 Metabolic pathways","GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0006464 cellular protein modification process; GO:0006497 protein lipidation; GO:0006505 GPI anchor metabolic process; GO:0006506 GPI anchor biosynthetic process; GO:0006621 protein retention in ER lumen; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006664 glycolipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009247 glycolipid biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016255 attachment of GPI anchor to protein; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032507 maintenance of protein location in cell; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0034645 cellular macromolecule biosynthetic process; GO:0035437 maintenance of protein localization in endoplasmic reticulum; GO:0036211 protein modification process; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042157 lipoprotein metabolic process; GO:0042158 lipoprotein biosynthetic process; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044091 membrane biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045185 maintenance of protein location; GO:0045313 rhabdomere membrane biogenesis; GO:0046467 membrane lipid biosynthetic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048592 eye morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051235 maintenance of location; GO:0051641 cellular localization; GO:0051651 maintenance of location in cell; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070972 protein localization to endoplasmic reticulum; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072595 maintenance of protein localization in organelle; GO:0090407 organophosphate biosynthetic process; GO:0090596 sensory organ morphogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903509 liposaccharide metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042765 GPI-anchor transamidase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex;","GO:0003824 catalytic activity; GO:0003923 GPI-anchor transamidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0016787 hydrolase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG3566","Glycosylphosphatidylinositol anchor attachment protein GAA1",{"$nulls":3},"R-HSA-162791 Attachment of GPI anchor to uPAR;R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-162791;https://reactome.org/PathwayBrowser/#/R-HSA-163125;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["O43293","Death-associated protein kinase 3 OS=Homo sapiens OX=9606 GN=DAPK3 PE=1 SV=1","DAPK3",1.245845302,0.018588513,"nochange",5373.51,5342.49,5771.36,6882.29,7430.79,6227.62,0.870719665,0.865693207,0.935186991,1.115201282,1.204079825,1.00911903,"cytoplasm","K08803","DAPK; death-associated protein kinase [EC:2.7.11.1]","hsa04140 Autophagy - animal; hsa05200 Pathways in cancer; hsa05219 Bladder cancer","GO:0001952 regulation of cell-matrix adhesion; GO:0002376 immune system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006417 regulation of translation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006937 regulation of muscle contraction; GO:0006940 regulation of smooth muscle contraction; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008360 regulation of cell shape; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010810 regulation of cell-substrate adhesion; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0016310 phosphorylation; GO:0017148 negative regulation of translation; GO:0018105 peptidyl-serine phosphorylation; GO:0018107 peptidyl-threonine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0018210 peptidyl-threonine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0034097 response to cytokine; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034341 response to interferon-gamma; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043519 regulation of myosin II filament organization; GO:0044057 regulation of system process; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0046777 protein autophosphorylation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051493 regulation of cytoskeleton organization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051893 regulation of focal adhesion assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090109 regulation of cell-substrate junction assembly; GO:0090257 regulation of muscle system process; GO:0090263 positive regulation of canonical Wnt signaling pathway; GO:0097190 apoptotic signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901888 regulation of cell junction assembly; GO:1903391 regulation of adherens junction organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000249 regulation of actin cytoskeleton reorganization; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001238 positive regulation of extrinsic apoptotic signaling pathway; GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand; GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016605 PML body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045121 membrane raft; GO:0070013 intracellular organelle lumen; GO:0098857 membrane microdomain; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008022 protein C-terminus binding; GO:0008134 transcription factor binding; GO:0008140 cAMP response element binding protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030275 LRR domain binding; GO:0030554 adenyl nucleotide binding; GO:0031267 small GTPase binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043522 leucine zipper domain binding; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00069","PF00069 Protein kinase domain","T","KOG0032","Ca2+/calmodulin-dependent protein kinase"," EF-Hand protein superfamily","WP2828 BLADDER CANCER","http://www.wikipathways.org/instance/WP2828_r119245",null,"R-HSA-109581 Apoptosis;R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand;R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway;R-HSA-5357801 Programmed Cell Death","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-418889;https://reactome.org/PathwayBrowser/#/R-HSA-5357769;https://reactome.org/PathwayBrowser/#/R-HSA-5357801"]
["O43294","Transforming growth factor beta-1-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=TGFB1I1 PE=1 SV=2","TGFB1I1",0.578649055,0.256289254,"nochange",4130.75,4342.16,3720.18,"NA",2938.59,1765.09,1.222349005,1.284908299,1.100855371,"NA",0.869571522,0.522315804,"nucleus","K24315",null,null,"GO:0000003 reproduction; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007444 imaginal disc development; GO:0007610 behavior; GO:0007631 feeding behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010717 regulation of epithelial to mesenchymal transition; GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0010830 regulation of myotube differentiation; GO:0010927 cellular component assembly involved in morphogenesis; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016331 morphogenesis of embryonic epithelium; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway; GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030521 androgen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0030579 ubiquitin-dependent SMAD protein catabolic process; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032507 maintenance of protein location in cell; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035295 tube development; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042755 eating behavior; GO:0043050 pharyngeal pumping; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045165 cell fate commitment; GO:0045185 maintenance of protein location; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045598 regulation of fat cell differentiation; GO:0045599 negative regulation of fat cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046843 dorsal appendage formation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051147 regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051651 maintenance of location in cell; GO:0051716 cellular response to stimulus; GO:0060142 regulation of syncytium formation by plasma membrane fusion; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090288 negative regulation of cellular response to growth factor stimulus; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901739 regulation of myoblast fusion; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus; GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0002102 podosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0005927 muscle tendon junction; GO:0015629 actin cytoskeleton; GO:0016363 nuclear matrix; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0031430 M band; GO:0031672 A band; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0055120 striated muscle dense body; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008134 transcription factor binding; GO:0017166 vinculin binding; GO:0046332 SMAD binding; GO:0048495 Roundabout binding; GO:0050681 androgen receptor binding; GO:0051427 hormone receptor binding; GO:0070411 I-SMAD binding; GO:0140110 transcription regulator activity;","PF00412","PF00412 LIM domain","TZ","KOG1703","Adaptor protein Enigma and related PDZ-LIM proteins","WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY;WP727 MONOAMINE TRANSPORT;WP1455 SEROTONIN TRANSPORTER ACTIVITY;WP366 TGFBETA SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP138_r120688;http://www.wikipathways.org/instance/WP727_r116775;http://www.wikipathways.org/instance/WP1455_r117827;http://www.wikipathways.org/instance/WP366_r120697"]
["O43296","Zinc finger protein 264 OS=Homo sapiens OX=9606 GN=ZNF264 PE=1 SV=1","ZNF264",1.068971617,0.666848913,"nochange",5746.42,5864.71,5121.84,7230.52,5747.67,4908.88,0.995912194,1.016413037,0.887666219,1.253121602,0.996128832,0.850758116,"nucleus","K09228","KRAB; KRAB domain-containing zinc finger protein","hsa05168 Herpes simplex virus 1 infection","GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;",null,"GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["O43298","Zinc finger and BTB domain-containing protein 43 OS=Homo sapiens OX=9606 GN=ZBTB43 PE=1 SV=1","ZBTB43",2.167042298,0.03060507,"nochange",2951.26,2933.4,1480.72,6366.8,4710.29,4884,0.759118718,0.754524795,0.380868601,1.637658849,1.211573804,1.256255233,"nucleus","K10514",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;",null,"GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00651; PF00096","PF00651 BTB/POZ domain; PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger"]
["O43299","AP-5 complex subunit zeta-1 OS=Homo sapiens OX=9606 GN=AP5Z1 PE=1 SV=2","AP5Z1",0.779476599,0.01050394,"nochange",4556.07,4397.44,4288.35,3357.24,3791.68,3172.8,1.160113192,1.119721197,1.091943584,0.854854823,0.965476383,0.807890821,"nucleus","K19025",null,null,"GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048475 coated membrane; GO:0070013 intracellular organelle lumen; GO:0098796 membrane protein complex;"]
["O43306","Adenylate cyclase type 6 OS=Homo sapiens OX=9606 GN=ADCY6 PE=1 SV=2","ADCY6",2.034157184,0.002691275,"up",1691.8,1293.47,1248.1,2775.97,2678.16,3157.21,0.790270859,0.604203598,0.583010438,1.296706582,1.251017734,1.474790789,"plasma membrane","K08046","ADCY6; adenylate cyclase 6 [EC:4.6.1.1]","hsa04923 Regulation of lipolysis in adipocytes; hsa04270 Vascular smooth muscle contraction; hsa04962 Vasopressin-regulated water reabsorption; hsa05166 Human T-cell leukemia virus 1 infection; hsa05200 Pathways in cancer; hsa04935 Growth hormone synthesis"," secretion and action; hsa04371 Apelin signaling pathway; hsa04261 Adrenergic signaling in cardiomyocytes; hsa04742 Taste transduction; hsa04211 Longevity regulating pathway; hsa04714 Thermogenesis; hsa05414 Dilated cardiomyopathy; hsa04914 Progesterone-mediated oocyte maturation; hsa04934 Cushing syndrome; hsa04971 Gastric acid secretion; hsa04915 Estrogen signaling pathway; hsa04925 Aldosterone synthesis and secretion; hsa05032 Morphine addiction; hsa04072 Phospholipase D signaling pathway; hsa04724 Glutamatergic synapse; hsa04928 Parathyroid hormone synthesis"," secretion and action; hsa04540 Gap junction; hsa04976 Bile secretion; hsa00230 Purine metabolism; hsa04611 Platelet activation; hsa04725 Cholinergic synapse; hsa04972 Pancreatic secretion; hsa04913 Ovarian steroidogenesis; hsa04921 Oxytocin signaling pathway; hsa04727 GABAergic synapse; hsa04713 Circadian entrainment; hsa05207 Chemical carcinogenesis - receptor activation; hsa04911 Insulin secretion; hsa04970 Salivary secretion; hsa04961 Endocrine and other factor-regulated calcium reabsorption; hsa04927 Cortisol synthesis and secretion; hsa04015 Rap1 signaling pathway; hsa04213 Longevity regulating pathway - multiple species; hsa01100 Metabolic pathways; hsa01522 Endocrine resistance; hsa04062 Chemokine signaling pathway; hsa04926 Relaxin signaling pathway; hsa04918 Thyroid hormone synthesis; hsa05163 Human cytomegalovirus infection; hsa04750 Inflammatory mediator regulation of TRP channels; hsa04912 GnRH signaling pathway; hsa04723 Retrograde endocannabinoid signaling; hsa04024 cAMP signaling pathway; hsa04916 Melanogenesis; hsa04924 Renin secretion; hsa04022 cGMP-PKG signaling pathway; hsa04114 Oocyte meiosis","GO:0000003 reproduction; GO:0001101 response to acid chemical; GO:0002791 regulation of peptide secretion; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003014 renal system process; GO:0003018 vascular process in circulatory system; GO:0003091 renal water homeostasis; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006171 cAMP biosynthetic process; GO:0006182 cGMP biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006928 movement of cell or subcellular component; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007187 G protein-coupled receptor signaling pathway"," coupled to cyclic nucleotide second messenger; GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway; GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007212 dopamine receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007338 single fertilization; GO:0007340 acrosome reaction; GO:0007399 nervous system development; GO:0007600 sensory perception; GO:0007606 sensory perception of chemical stimulus; GO:0007608 sensory perception of smell; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007623 circadian rhythm; GO:0007635 chemosensory behavior; GO:0008015 blood circulation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008306 associative learning; GO:0008355 olfactory learning; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009187 cyclic nucleotide metabolic process; GO:0009190 cyclic nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009566 fertilization; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010243 response to organonitrogen compound; GO:0010646 regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010817 regulation of hormone levels; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0014070 response to organic cyclic compound; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019725 cellular homeostasis; GO:0019932 second-messenger-mediated signaling; GO:0019933 cAMP-mediated signaling; GO:0019935 cyclic-nucleotide-mediated signaling; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030003 cellular cation homeostasis; GO:0030104 water homeostasis; GO:0030154 cell differentiation; GO:0030317 flagellated sperm motility; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032507 maintenance of protein location in cell; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033762 response to glucagon; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034694 response to prostaglandin; GO:0034695 response to prostaglandin E; GO:0035150 regulation of tube size; GO:0035296 regulation of tube diameter; GO:0035556 intracellular signal transduction; GO:0035809 regulation of urine volume; GO:0035811 negative regulation of urine volume; GO:0040011 locomotion; GO:0042048 olfactory behavior; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0042752 regulation of circadian rhythm; GO:0043434 response to peptide hormone; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045185 maintenance of protein location; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0046058 cAMP metabolic process; GO:0046068 cGMP metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046677 response to antibiotic; GO:0046883 regulation of hormone secretion; GO:0048511 rhythmic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048871 multicellular organismal homeostasis; GO:0048878 chemical homeostasis; GO:0050708 regulation of protein secretion; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050801 ion homeostasis; GO:0050877 nervous system process; GO:0050878 regulation of body fluid levels; GO:0050890 cognition; GO:0050891 multicellular organismal water homeostasis; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051480 regulation of cytosolic calcium ion concentration; GO:0051592 response to calcium ion; GO:0051641 cellular localization; GO:0051651 maintenance of location in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0052652 cyclic purine nucleotide metabolic process; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060281 regulation of oocyte development; GO:0060282 positive regulation of oocyte development; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0061478 response to platelet aggregation inhibitor; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070542 response to fatty acid; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071236 cellular response to antibiotic; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071277 cellular response to calcium ion; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071377 cellular response to glucagon stimulus; GO:0071379 cellular response to prostaglandin stimulus; GO:0071380 cellular response to prostaglandin E stimulus; GO:0071396 cellular response to lipid; GO:0071398 cellular response to fatty acid; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071867 response to monoamine; GO:0071868 cellular response to monoamine stimulus; GO:0071869 response to catecholamine; GO:0071870 cellular response to catecholamine stimulus; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072657 protein localization to membrane; GO:0072658 maintenance of protein location in membrane; GO:0072659 protein localization to plasma membrane; GO:0072660 maintenance of protein location in plasma membrane; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090407 organophosphate biosynthetic process; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097722 sperm motility; GO:0097746 blood vessel diameter maintenance; GO:0098771 inorganic ion homeostasis; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900193 regulation of oocyte maturation; GO:1900195 positive regulation of oocyte maturation; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903429 regulation of cell maturation; GO:1903431 positive regulation of cell maturation; GO:1903530 regulation of secretion by cell; GO:1904116 response to vasopressin; GO:1904117 cellular response to vasopressin; GO:1904321 response to forskolin; GO:1904322 cellular response to forskolin; GO:1905879 regulation of oogenesis; GO:1905881 positive regulation of oogenesis; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005902 microvillus; GO:0005929 cilium; GO:0008074 guanylate cyclase complex"," soluble; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031253 cell projection membrane; GO:0031410 cytoplasmic vesicle; GO:0031528 microvillus membrane; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045111 intermediate filament cytoskeleton; GO:0045121 membrane raft; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098857 membrane microdomain; GO:0098858 actin-based cell projection; GO:0120025 plasma membrane bounded cell projection;","GO:0000149 SNARE binding; GO:0003824 catalytic activity; GO:0004016 adenylate cyclase activity; GO:0004383 guanylate cyclase activity; GO:0005080 protein kinase C binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008179 adenylate cyclase binding; GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity; GO:0009975 cyclase activity; GO:0016829 lyase activity; GO:0016849 phosphorus-oxygen lyase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097110 scaffold protein binding;","PF00211","PF00211 Adenylate and Guanylate cyclase catalytic domain","C","KOG3619","Adenylate/guanylate cyclase","WP536 CALCIUM REGULATION IN CARDIAC CELLS;WP3929 CHEMOKINE SIGNALING PATHWAY;WP4803 CILIOPATHIES;WP4535 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY;WP35 G PROTEIN SIGNALING PATHWAYS;WP4589 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE;WP289 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS;WP4222 PHOSPHODIESTERASES IN NEURONAL FUNCTION;WP4321 THERMOGENESIS;WP5085 VASOPRESSINREGULATED WATER REABSORPTION","http://www.wikipathways.org/instance/WP536_r116854;http://www.wikipathways.org/instance/WP3929_r119247;http://www.wikipathways.org/instance/WP4803_r110008;http://www.wikipathways.org/instance/WP4535_r109210;http://www.wikipathways.org/instance/WP35_r117729;http://www.wikipathways.org/instance/WP4589_r119266;http://www.wikipathways.org/instance/WP289_r120734;http://www.wikipathways.org/instance/WP4222_r107160;http://www.wikipathways.org/instance/WP4321_r106178;http://www.wikipathways.org/instance/WP5085_r119785",null,"R-HSA-111885 Opioid Signalling;R-HSA-111931 PKA-mediated phosphorylation of CREB;R-HSA-111933 Calmodulin induced events;R-HSA-111996 Ca-dependent events;R-HSA-111997 CaM pathway;R-HSA-112040 G-protein mediated events;R-HSA-112043 PLC beta mediated events;R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission;R-HSA-112315 Transmission across Chemical Synapses;R-HSA-112316 Neuronal System;R-HSA-1430728 Metabolism;R-HSA-1489509 DAG and IP3 signaling;R-HSA-162582 Signal Transduction;R-HSA-163359 Glucagon signaling in metabolic regulation;R-HSA-163615 PKA activation;R-HSA-163685 Integration of energy metabolism;R-HSA-1643685 Disease;R-HSA-164378 PKA activation in glucagon signalling;R-HSA-170660 Adenylate cyclase activating pathway;R-HSA-170670 Adenylate cyclase inhibitory pathway;R-HSA-372790 Signaling by GPCR;R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;R-HSA-382551 Transport of small molecules;R-HSA-388396 GPCR downstream signalling;R-HSA-400042 Adrenaline","noradrenaline inhibits insulin secretion;R-HSA-418555 G alpha (s) signalling events;R-HSA-418594 G alpha (i) signalling events;R-HSA-418597 G alpha (z) signalling events;R-HSA-422356 Regulation of insulin secretion;R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins;R-HSA-445717 Aquaporin-mediated transport;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5663205 Infectious disease;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9634597 GPER1 signaling;R-HSA-9658195 Leishmania infection;R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production;R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection;R-HSA-9664323 FCGR3A-mediated IL10 synthesis;R-HSA-9664433 Leishmania parasite growth and survival;R-HSA-977443 GABA receptor activation;R-HSA-977444 GABA B receptor activation;R-HSA-991365 Activation of GABAB receptors",null,"ADIPOGENESIS;DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O43310","CBP80/20-dependent translation initiation factor OS=Homo sapiens OX=9606 GN=CTIF PE=1 SV=1","CTIF",1.1392793,0.072098729,"nochange",2916.63,3399.6,2976.68,3697.75,3501.32,3388.15,0.880264867,1.026029508,0.898388491,1.116013829,1.056729508,1.022573796,"nucleus",{"$nulls":3},"GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0034248 regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0048471 perinuclear region of cytoplasm;",{"$nulls":3},"J","KOG3942","MIF4G domain-containing protein"]
["O43312","Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=2","MTSS1",1.301647513,0.000260351,"up",29316.1,31128.1,31269.8,40147.2,39902.9,39329.2,0.833264722,0.884768015,0.888795618,1.141121959,1.13417811,1.117871576,"nucleus","K20128",null,null,"GO:0001503 ossification; GO:0001655 urogenital system development; GO:0001701 in utero embryonic development; GO:0001822 kidney development; GO:0002009 morphogenesis of an epithelium; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007517 muscle organ development; GO:0008154 actin polymerization or depolymerization; GO:0008283 cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010638 positive regulation of organelle organization; GO:0010960 magnesium ion homeostasis; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030035 microspike assembly; GO:0030036 actin cytoskeleton organization; GO:0030041 actin filament polymerization; GO:0030154 cell differentiation; GO:0030282 bone mineralization; GO:0030855 epithelial cell differentiation; GO:0031214 biomineral tissue development; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032835 glomerulus development; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0034330 cell junction organization; GO:0034331 cell junction maintenance; GO:0034332 adherens junction organization; GO:0034334 adherens junction maintenance; GO:0034405 response to fluid shear stress; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035850 epithelial cell differentiation involved in kidney development; GO:0042127 regulation of cell population proliferation; GO:0042592 homeostatic process; GO:0043009 chordate embryonic development; GO:0043933 protein-containing complex organization; GO:0043954 cellular component maintenance; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045216 cell-cell junction organization; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050673 epithelial cell proliferation; GO:0050678 regulation of epithelial cell proliferation; GO:0050680 negative regulation of epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051258 protein polymerization; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055080 cation homeostasis; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061005 cell differentiation involved in kidney development; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0061326 renal tubule development; GO:0061333 renal tubule morphogenesis; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071498 cellular response to fluid shear stress; GO:0071840 cellular component organization or biogenesis; GO:0072001 renal system development; GO:0072006 nephron development; GO:0072009 nephron epithelium development; GO:0072073 kidney epithelium development; GO:0072080 nephron tubule development; GO:0072102 glomerulus morphogenesis; GO:0072160 nephron tubule epithelial cell differentiation; GO:0072507 divalent inorganic cation homeostasis; GO:0097435 supramolecular fiber organization; GO:0098771 inorganic ion homeostasis; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005912 adherens junction; GO:0009898 cytoplasmic side of plasma membrane; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030054 cell junction; GO:0030139 endocytic vesicle; GO:0030175 filopodium; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098858 actin-based cell projection; GO:0120025 plasma membrane bounded cell projection;","GO:0003779 actin binding; GO:0003785 actin monomer binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0042802 identical protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;"]
["O43314","Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3","PPIP5K2",0.798250176,0.010996703,"nochange",19107.6,16185.8,17580.5,14207.9,14309.4,13689.3,1.205774055,1.021395554,1.109407292,0.896581318,0.902986417,0.863855365,"nucleus","K13024","PPIP5K; inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase [EC:2.7.4.24]","hsa04070 Phosphatidylinositol signaling system","GO:0005975 carbohydrate metabolic process; GO:0006020 inositol metabolic process; GO:0006066 alcohol metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0032958 inositol phosphate biosynthetic process; GO:0043647 inositol phosphate metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046165 alcohol biosynthetic process; GO:0046173 polyol biosynthetic process; GO:0071704 organic substance metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0000166 nucleotide binding; GO:0000827 inositol-1",3,4,5,"6-pentakisphosphate kinase activity; GO:0000828 inositol hexakisphosphate kinase activity; GO:0000829 inositol heptakisphosphate kinase activity; GO:0000832 inositol hexakisphosphate 5-kinase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016776 phosphotransferase activity"," phosphate group as acceptor; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0033857 diphosphoinositol-pentakisphosphate kinase activity; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF18086","PF18086 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain","Z","KOG1057","Arp2/3 complex-interacting protein VIP1/Asp1"," involved in regulation of actin cytoskeleton",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483249 Inositol phosphate metabolism;R-HSA-1855167 Synthesis of pyrophosphates in the cytosol","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483249;https://reactome.org/PathwayBrowser/#/R-HSA-1855167"]
["O43318","Mitogen-activated protein kinase kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP3K7 PE=1 SV=1","MAP3K7",1.487995578,1.35103E-3,"up",4757.95,4434.19,4574.87,7044.71,6229.67,7210.87,0.833454493,0.776741155,0.801384201,1.234028353,1.091257044,1.263134754,"nucleus","K04427","MAP3K7; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]","hsa04380 Osteoclast differentiation; hsa04622 RIG-I-like receptor signaling pathway; hsa05161 Hepatitis B; hsa05170 Human immunodeficiency virus 1 infection; hsa05169 Epstein-Barr virus infection; hsa05418 Fluid shear stress and atherosclerosis; hsa05131 Shigellosis; hsa04310 Wnt signaling pathway; hsa05132 Salmonella infection; hsa04621 NOD-like receptor signaling pathway; hsa05168 Herpes simplex virus 1 infection; hsa05145 Toxoplasmosis; hsa04660 T cell receptor signaling pathway; hsa04152 AMPK signaling pathway; hsa05135 Yersinia infection; hsa04010 MAPK signaling pathway; hsa05171 Coronavirus disease - COVID-19; hsa04936 Alcoholic liver disease; hsa04613 Neutrophil extracellular trap formation; hsa05162 Measles; hsa05140 Leishmaniasis; hsa04140 Autophagy - animal; hsa04668 TNF signaling pathway; hsa04520 Adherens junction; hsa04620 Toll-like receptor signaling pathway; hsa05130 Pathogenic Escherichia coli infection; hsa04657 IL-17 signaling pathway; hsa04064 NF-kappa B signaling pathway; hsa05417 Lipid and atherosclerosis","GO:0000165 MAPK cascade; GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001654 eye development; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001704 formation of primary germ layer; GO:0001706 endoderm formation; GO:0001708 cell fate specification; GO:0001709 cell fate determination; GO:0001711 endodermal cell fate commitment; GO:0001714 endodermal cell fate specification; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001944 vasculature development; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002218 activation of innate immune response; GO:0002220 innate immune response activating cell surface receptor signaling pathway; GO:0002221 pattern recognition receptor signaling pathway; GO:0002223 stimulatory C-type lectin receptor signaling pathway; GO:0002224 toll-like receptor signaling pathway; GO:0002225 positive regulation of antimicrobial peptide production; GO:0002237 response to molecule of bacterial origin; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002702 positive regulation of production of molecular mediator of immune response; GO:0002703 regulation of leukocyte mediated immunity; GO:0002705 positive regulation of leukocyte mediated immunity; GO:0002706 regulation of lymphocyte mediated immunity; GO:0002708 positive regulation of lymphocyte mediated immunity; GO:0002709 regulation of T cell mediated immunity; GO:0002711 positive regulation of T cell mediated immunity; GO:0002718 regulation of cytokine production involved in immune response; GO:0002720 positive regulation of cytokine production involved in immune response; GO:0002724 regulation of T cell cytokine production; GO:0002726 positive regulation of T cell cytokine production; GO:0002753 cytoplasmic pattern recognition receptor signaling pathway; GO:0002755 MyD88-dependent toll-like receptor signaling pathway; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002759 regulation of antimicrobial humoral response; GO:0002760 positive regulation of antimicrobial humoral response; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0002784 regulation of antimicrobial peptide production; GO:0002786 regulation of antibacterial peptide production; GO:0002803 positive regulation of antibacterial peptide production; GO:0002805 regulation of antimicrobial peptide biosynthetic process; GO:0002807 positive regulation of antimicrobial peptide biosynthetic process; GO:0002808 regulation of antibacterial peptide biosynthetic process; GO:0002813 regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; GO:0002819 regulation of adaptive immune response; GO:0002821 positive regulation of adaptive immune response; GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0002920 regulation of humoral immune response; GO:0002922 positive regulation of humoral immune response; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006508 proteolysis; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006963 positive regulation of antibacterial peptide biosynthetic process; GO:0006964 positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007179 transforming growth factor beta receptor signaling pathway; GO:0007223 Wnt signaling pathway"," calcium modulating pathway; GO:0007249 I-kappaB kinase/NF-kappaB signaling; GO:0007250 activation of NF-kappaB-inducing kinase activity; GO:0007252 I-kappaB phosphorylation; GO:0007254 JNK cascade; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007389 pattern specification process; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007477 notum development; GO:0007492 endoderm development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008356 asymmetric cell division; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010939 regulation of necrotic cell death; GO:0010941 regulation of cell death; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016310 phosphorylation; GO:0016318 ommatidial rotation; GO:0016331 morphogenesis of embryonic epithelium; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0016579 protein deubiquitination; GO:0018107 peptidyl-threonine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018210 peptidyl-threonine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0021915 neural tube development; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030522 intracellular receptor signaling pathway; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032663 regulation of interleukin-2 production; GO:0032743 positive regulation of interleukin-2 production; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0035148 tube formation; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0035567 non-canonical Wnt signaling pathway; GO:0035872 nucleotide-binding domain"," leucine rich repeat containing receptor signaling pathway; GO:0035987 endodermal cell differentiation; GO:0036211 protein modification process; GO:0038061 NIK/NF-kappaB signaling; GO:0038093 Fc receptor signaling pathway; GO:0038095 Fc-epsilon receptor signaling pathway; GO:0042067 establishment of ommatidial planar polarity; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042692 muscle cell differentiation; GO:0042693 muscle cell fate commitment; GO:0042694 muscle cell fate specification; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043254 regulation of protein-containing complex assembly; GO:0043276 anoikis; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043543 protein acylation; GO:0043549 regulation of kinase activity; GO:0043966 histone H3 acetylation; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045165 cell fate commitment; GO:0045167 asymmetric protein localization involved in cell fate determination; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046777 protein autophosphorylation; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048546 digestive tract morphogenesis; GO:0048557 embryonic digestive tract morphogenesis; GO:0048562 embryonic organ morphogenesis; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048565 digestive tract development; GO:0048566 embryonic digestive tract development; GO:0048568 embryonic organ development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048802 notum morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050829 defense response to Gram-negative bacterium; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051607 defense response to virus; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0055123 digestive system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060544 regulation of necroptotic process; GO:0060546 negative regulation of necroptotic process; GO:0060547 negative regulation of necrotic cell death; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060795 cell fate commitment involved in formation of primary germ layer; GO:0061057 peptidoglycan recognition protein signaling pathway; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070555 response to interleukin-1; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071363 cellular response to growth factor stimulus; GO:0071396 cellular response to lipid; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090596 sensory organ morphogenesis; GO:0098542 defense response to other organism; GO:0198738 cell-cell signaling by wnt; GO:1900424 regulation of defense response to bacterium; GO:1900426 positive regulation of defense response to bacterium; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901224 positive regulation of NIK/NF-kappaB signaling; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902442 regulation of ripoptosome assembly involved in necroptotic process; GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903506 regulation of nucleic acid-templated transcription; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000378 negative regulation of reactive oxygen species metabolic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway;","GO:0000123 histone acetyltransferase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031248 protein acetyltransferase complex; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1902562 H4 histone acetyltransferase complex; GO:1990234 transferase complex;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004706 JUN kinase kinase kinase activity; GO:0004708 MAP kinase kinase activity; GO:0004709 MAP kinase kinase kinase activity; GO:0004712 protein serine/threonine/tyrosine kinase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030554 adenyl nucleotide binding; GO:0030971 receptor tyrosine kinase binding; GO:0031625 ubiquitin protein ligase binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0097110 scaffold protein binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990782 protein tyrosine kinase binding;","PF07714","PF07714 Protein tyrosine and serine/threonine kinase","T","KOG0192","Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs","WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP2795 CARDIAC HYPERTROPHIC RESPONSE;WP710 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT;WP262 EBSTEINBARR VIRUS LMP1 SIGNALING;WP314 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS;WP4666 HEPATITIS B INFECTION;WP4880 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION;WP2112 IL17 SIGNALING PATHWAY;WP4754 IL18 SIGNALING PATHWAY;WP195 IL1 SIGNALING PATHWAY;WP364 IL6 SIGNALING PATHWAY;WP481 INSULIN SIGNALING;WP2637 INTERLEUKIN1 IL1 STRUCTURAL PATHWAY;WP4258 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER;WP382 MAPK SIGNALING PATHWAY;WP4630 MEASLES VIRUS INFECTION;WP4329 MIRNAS INVOLVEMENT IN THE IMMUNE RESPONSE IN SEPSIS;WP288 NODLIKE RECEPTOR NLR SIGNALING PATHWAY;WP3865 NOVEL INTRACELLULAR COMPONENTS OF RIGILIKE RECEPTOR RLR PATHWAY;WP400 P38 MAPK SIGNALING PATHWAY;WP2018 RANKLRANK SIGNALING PATHWAY;WP4496 SIGNAL TRANSDUCTION THROUGH IL1R;WP3863 TCELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY;WP366 TGFBETA SIGNALING PATHWAY;WP3851 TLR4 SIGNALING AND TOLERANCE;WP231 TNFALPHA SIGNALING PATHWAY;WP2036 TNFRELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING PATHWAY;WP75 TOLLLIKE RECEPTOR SIGNALING PATHWAY;WP428 WNT SIGNALING;WP363 WNT SIGNALING PATHWAY;WP399 WNT SIGNALING PATHWAY AND PLURIPOTENCY","http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP23_r120701;http://www.wikipathways.org/instance/WP2795_r117670;http://www.wikipathways.org/instance/WP710_r116542;http://www.wikipathways.org/instance/WP262_r116630;http://www.wikipathways.org/instance/WP314_r116694;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP4880_r119113;http://www.wikipathways.org/instance/WP2112_r117960;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP195_r120702;http://www.wikipathways.org/instance/WP364_r120715;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP2637_r117962;http://www.wikipathways.org/instance/WP4258_r117770;http://www.wikipathways.org/instance/WP382_r119087;http://www.wikipathways.org/instance/WP4630_r120771;http://www.wikipathways.org/instance/WP4329_r101725;http://www.wikipathways.org/instance/WP288_r118398;http://www.wikipathways.org/instance/WP3865_r106524;http://www.wikipathways.org/instance/WP400_r116725;http://www.wikipathways.org/instance/WP2018_r120672;http://www.wikipathways.org/instance/WP4496_r102693;http://www.wikipathways.org/instance/WP3863_r120420;http://www.wikipathways.org/instance/WP69_r120700;http://www.wikipathways.org/instance/WP366_r120697;http://www.wikipathways.org/instance/WP3851_r117847;http://www.wikipathways.org/instance/WP231_r120699;http://www.wikipathways.org/instance/WP2036_r120722;http://www.wikipathways.org/instance/WP75_r119233;http://www.wikipathways.org/instance/WP428_r116549;http://www.wikipathways.org/instance/WP363_r120695;http://www.wikipathways.org/instance/WP399_r119242",null,"R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168638 NOD1/2 Signaling Pathway;R-HSA-168643 Nucleotide-binding domain"," leucine rich repeat containing receptor (NLR) signaling pathways;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-195721 Signaling by WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086398 Ca2+ pathway;R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation  ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-448424 Interleukin-17 signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450294 MAP kinase activation;R-HSA-450302 activated TAK1 mediates p38 MAPK activation;R-HSA-450321 JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5663205 Infectious disease;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-73887 Death Receptor Signalling;R-HSA-75893 TNF signaling;R-HSA-9014325 TICAM1","TRAF6-dependent induction of TAK1 complex;R-HSA-9020702 Interleukin-1 signaling;R-HSA-937042 IRAK2 mediated activation of TAK1 complex;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex;R-HSA-9645460 Alpha-protein kinase 1 signaling pathway;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation;R-HSA-975871 MyD88 cascade initiated on plasma membrane;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"ALLOGRAFT REJECTION;PI3K AKT MTOR SIGNALING;TGF BETA SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TGF_BETA_SIGNALING"]
["O43324","Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1","EEF1E1",0.953875314,0.11023599,"nochange",44370.8,45930.7,46135.2,44487.9,43934.7,41721,0.998666443,1.033775564,1.038378305,1.001302047,0.988851014,0.939026627,"cytoplasm","K15439",null,null,"GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006414 translational elongation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006749 glutathione metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016070 RNA metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043516 regulation of DNA damage response"," signal transduction by p53 class mediator; GO:0043517 positive regulation of DNA damage response"," signal transduction by p53 class mediator; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0090342 regulation of cell aging; GO:0090343 positive regulation of cell aging; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901798 positive regulation of signal transduction by p53 class mediator; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor; GO:2000772 regulation of cellular senescence; GO:2000774 positive regulation of cellular senescence; GO:2001020 regulation of response to DNA damage stimulus; GO:2001022 positive regulation of response to DNA damage stimulus; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0017101 aminoacyl-tRNA synthetase multienzyme complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003746 translation elongation factor activity; GO:0003824 catalytic activity; GO:0004364 glutathione transferase activity; GO:0005488 binding; GO:0008135 translation factor activity"," RNA binding; GO:0016740 transferase activity; GO:0016765 transferase activity"," transferring alkyl or aryl (other than methyl) groups; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00043","PF00043 Glutathione S-transferase"," C-terminal domain","O","KOG0867","Glutathione S-transferase","WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR","http://www.wikipathways.org/instance/WP4016_r120667",null,"R-HSA-1430728 Metabolism;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-379716 Cytosolic tRNA aminoacylation;R-HSA-379724 tRNA Aminoacylation;R-HSA-392499 Metabolism of proteins;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-2408522;https://reactome.org/PathwayBrowser/#/R-HSA-379716;https://reactome.org/PathwayBrowser/#/R-HSA-379724;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-72766","MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["O43353","Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2","RIPK2",0.752182778,0.043680421,"nochange",13875.7,14198.5,14939.8,11183.6,12327.2,8843.59,1.104630204,1.13032798,1.18934211,0.890314892,0.981355712,0.704029103,"cytoplasm","K08846","RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]","hsa05132 Salmonella infection; hsa04722 Neurotrophin signaling pathway; hsa04621 NOD-like receptor signaling pathway; hsa05152 Tuberculosis; hsa05131 Shigellosis","GO:0000165 MAPK cascade; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001961 positive regulation of cytokine-mediated signaling pathway; GO:0002218 activation of innate immune response; GO:0002221 pattern recognition receptor signaling pathway; GO:0002224 toll-like receptor signaling pathway; GO:0002237 response to molecule of bacterial origin; GO:0002250 adaptive immune response; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002753 cytoplasmic pattern recognition receptor signaling pathway; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0002819 regulation of adaptive immune response; GO:0002821 positive regulation of adaptive immune response; GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002825 regulation of T-helper 1 type immune response; GO:0002827 positive regulation of T-helper 1 type immune response; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006508 proteolysis; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007249 I-kappaB kinase/NF-kappaB signaling; GO:0007254 JNK cascade; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010799 regulation of peptidyl-threonine phosphorylation; GO:0010800 positive regulation of peptidyl-threonine phosphorylation; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016310 phosphorylation; GO:0016485 protein processing; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030155 regulation of cell adhesion; GO:0030162 regulation of proteolysis; GO:0030522 intracellular receptor signaling pathway; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031638 zymogen activation; GO:0031663 lipopolysaccharide-mediated signaling pathway; GO:0032092 positive regulation of protein binding; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032494 response to peptidoglycan; GO:0032495 response to muramyl dipeptide; GO:0032496 response to lipopolysaccharide; GO:0032642 regulation of chemokine production; GO:0032647 regulation of interferon-alpha production; GO:0032648 regulation of interferon-beta production; GO:0032649 regulation of interferon-gamma production; GO:0032651 regulation of interleukin-1 beta production; GO:0032652 regulation of interleukin-1 production; GO:0032655 regulation of interleukin-12 production; GO:0032663 regulation of interleukin-2 production; GO:0032675 regulation of interleukin-6 production; GO:0032680 regulation of tumor necrosis factor production; GO:0032722 positive regulation of chemokine production; GO:0032727 positive regulation of interferon-alpha production; GO:0032728 positive regulation of interferon-beta production; GO:0032729 positive regulation of interferon-gamma production; GO:0032731 positive regulation of interleukin-1 beta production; GO:0032732 positive regulation of interleukin-1 production; GO:0032735 positive regulation of interleukin-12 production; GO:0032743 positive regulation of interleukin-2 production; GO:0032755 positive regulation of interleukin-6 production; GO:0032760 positive regulation of tumor necrosis factor production; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032943 mononuclear cell proliferation; GO:0032944 regulation of mononuclear cell proliferation; GO:0032946 positive regulation of mononuclear cell proliferation; GO:0033083 regulation of immature T cell proliferation; GO:0033091 positive regulation of immature T cell proliferation; GO:0033135 regulation of peptidyl-serine phosphorylation; GO:0033138 positive regulation of peptidyl-serine phosphorylation; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034134 toll-like receptor 2 signaling pathway; GO:0034142 toll-like receptor 4 signaling pathway; GO:0035556 intracellular signal transduction; GO:0035872 nucleotide-binding domain"," leucine rich repeat containing receptor signaling pathway; GO:0036211 protein modification process; GO:0042098 T cell proliferation; GO:0042102 positive regulation of T cell proliferation; GO:0042110 T cell activation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043330 response to exogenous dsRNA; GO:0043331 response to dsRNA; GO:0043370 regulation of CD4-positive"," alpha-beta T cell differentiation; GO:0043372 positive regulation of CD4-positive"," alpha-beta T cell differentiation; GO:0043393 regulation of protein binding; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045321 leukocyte activation; GO:0045580 regulation of T cell differentiation; GO:0045582 positive regulation of T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045621 positive regulation of lymphocyte differentiation; GO:0045622 regulation of T-helper cell differentiation; GO:0045624 positive regulation of T-helper cell differentiation; GO:0045625 regulation of T-helper 1 cell differentiation; GO:0045627 positive regulation of T-helper 1 cell differentiation; GO:0045785 positive regulation of cell adhesion; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045862 positive regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046634 regulation of alpha-beta T cell activation; GO:0046635 positive regulation of alpha-beta T cell activation; GO:0046637 regulation of alpha-beta T cell differentiation; GO:0046638 positive regulation of alpha-beta T cell differentiation; GO:0046640 regulation of alpha-beta T cell proliferation; GO:0046641 positive regulation of alpha-beta T cell proliferation; GO:0046649 lymphocyte activation; GO:0046651 lymphocyte proliferation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050670 regulation of lymphocyte proliferation; GO:0050671 positive regulation of lymphocyte proliferation; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050830 defense response to Gram-positive bacterium; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051604 protein maturation; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060759 regulation of response to cytokine stimulus; GO:0060760 positive regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070374 positive regulation of ERK1 and ERK2 cascade; GO:0070391 response to lipoteichoic acid; GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway; GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway; GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070555 response to interleukin-1; GO:0070661 leukocyte proliferation; GO:0070663 regulation of leukocyte proliferation; GO:0070665 positive regulation of leukocyte proliferation; GO:0070671 response to interleukin-12; GO:0070673 response to interleukin-18; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071223 cellular response to lipoteichoic acid; GO:0071224 cellular response to peptidoglycan; GO:0071225 cellular response to muramyl dipeptide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071396 cellular response to lipid; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0097202 activation of cysteine-type endopeptidase activity; GO:0098542 defense response to other organism; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1904415 regulation of xenophagy; GO:1904417 positive regulation of xenophagy; GO:1904951 positive regulation of establishment of protein localization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000514 regulation of CD4-positive"," alpha-beta T cell activation; GO:2000516 positive regulation of CD4-positive"," alpha-beta T cell activation; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0002020 protease binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030274 LIM domain binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0050700 CARD domain binding; GO:0089720 caspase binding; GO:0140096 catalytic activity"," acting on a protein;","PF07714; PF00619","PF07714 Protein tyrosine and serine/threonine kinase; PF00619 Caspase recruitment domain","T","KOG0192","Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs","WP2864 APOPTOSISRELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER;WP314 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS;WP1433 NUCLEOTIDEBINDING OLIGOMERIZATION DOMAIN NOD PATHWAY;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2864_r108133;http://www.wikipathways.org/instance/WP314_r116694;http://www.wikipathways.org/instance/WP1433_r117810;http://www.wikipathways.org/instance/WP69_r120700",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168638 NOD1/2 Signaling Pathway;R-HSA-168643 Nucleotide-binding domain"," leucine rich repeat containing receptor (NLR) signaling pathways;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-193639 p75NTR signals via NF-kB;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-209543 p75NTR recruits signalling complexes;R-HSA-392499 Metabolism of proteins;R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation  ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-448424 Interleukin-17 signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450294 MAP kinase activation;R-HSA-450302 activated TAK1 mediates p38 MAPK activation;R-HSA-450321 JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;R-HSA-5663205 Infectious disease;R-HSA-5688426 Deubiquitination;R-HSA-5689896 Ovarian tumor domain proteases;R-HSA-597592 Post-translational protein modification;R-HSA-73887 Death Receptor Signalling;R-HSA-9020702 Interleukin-1 signaling;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-975871 MyD88 cascade initiated on plasma membrane",null,"ALLOGRAFT REJECTION;INFLAMMATORY RESPONSE;INTERFERON ALPHA RESPONSE;INTERFERON GAMMA RESPONSE;TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["O43379","WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4","WDR62",0.71199969,0.045591223,"nochange",2601.39,2180.55,2958.26,1680.03,2133.8,1697.19,1.177879471,0.987327959,1.339466102,0.76069826,0.966160097,0.768468111,"nucleus","K21762",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007098 centrosome cycle; GO:0007099 centriole replication; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0019827 stem cell population maintenance; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021987 cerebral cortex development; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030900 forebrain development; GO:0031023 microtubule organizing center organization; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032677 regulation of interleukin-8 production; GO:0032717 negative regulation of interleukin-8 production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051298 centrosome duplication; GO:0051726 regulation of cell cycle; GO:0060322 head development; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0097150 neuronal stem cell population maintenance; GO:0098534 centriole assembly; GO:0098727 maintenance of cell number; GO:1900424 regulation of defense response to bacterium; GO:1900425 negative regulation of defense response to bacterium; GO:1901360 organic cyclic compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization;","GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005681 spliceosomal complex; GO:0005682 U5 snRNP; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031021 interphase microtubule organizing center; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071011 precatalytic spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:0072686 mitotic spindle; GO:0097431 mitotic spindle pole; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"S","KOG1408","WD40 repeat protein"]
["O43390","Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1","HNRNPR",1.189214492,0.00011311,"up",269834,275717,275866,320717,330754,325370,0.900317974,0.919946971,0.920444119,1.070092278,1.103581355,1.085617303,"nucleus","K13161",null,null,"GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007310 oocyte dorsal/ventral axis specification; GO:0007389 pattern specification process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009950 dorsal/ventral axis specification; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010927 cellular component assembly involved in morphogenesis; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0030154 cell differentiation; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0034248 regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0040008 regulation of growth; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0045886 negative regulation of synaptic assembly at neuromuscular junction; GO:0045926 negative regulation of growth; GO:0046011 regulation of oskar mRNA translation; GO:0046483 heterocycle metabolic process; GO:0046843 dorsal appendage formation; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050807 regulation of synapse organization; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051964 negative regulation of synapse assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0099177 regulation of trans-synaptic signaling; GO:1900073 regulation of neuromuscular synaptic transmission; GO:1901360 organic cyclic compound metabolic process; GO:1904396 regulation of neuromuscular junction development; GO:1904397 negative regulation of neuromuscular junction development; GO:1905809 negative regulation of synapse organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0031594 neuromuscular junction; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0071013 catalytic step 2 spliceosome; GO:0098794 postsynapse; GO:0098975 postsynapse of neuromuscular junction; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF18360; PF00076","PF18360 Heterogeneous nuclear ribonucleoprotein Q acidic domain; PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","A","KOG0117","Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160","Transcription factor","R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O43395","U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2","PRPF3",1.398740207,0.000956065,"up",45074.1,44358,48479.5,62565.2,67836.2,62501.1,0.817512313,0.804524354,0.879276307,1.134749698,1.230350218,1.133587111,"nucleus","K12843","PRPF3; U4/U6 small nuclear ribonucleoprotein PRP3","hsa03040 Spliceosome","GO:0000244 spliceosomal tri-snRNP complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1902275 regulation of chromatin organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0015030 Cajal body; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0046540 U4/U6 x U5 tri-snRNP complex; GO:0070013 intracellular organelle lumen; GO:0071005 U2-type precatalytic spliceosome; GO:0071011 precatalytic spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0097526 spliceosomal tri-snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF08572; PF06544","PF08572 pre-mRNA processing factor 3 (PRP3); PF06544 Protein of unknown function (DUF1115)","A","KOG2769","Putative u4/u6 small nuclear ribonucleoprotein","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["O43396","Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3","TXNL1",1.317141424,0.003887407,"up",106686,116150,124148,148924,151594,156509,0.796153286,0.866779186,0.926464936,1.111357929,1.13128303,1.167961632,"cytoplasm",{"$nulls":3},"GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0008152 metabolic process; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0019725 cellular homeostasis; GO:0033554 cellular response to stress; GO:0034599 cellular response to oxidative stress; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0045454 cell redox homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0097237 cellular response to toxic substance; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1990748 cellular detoxification;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004791 thioredoxin-disulfide reductase activity; GO:0015035 protein-disulfide reductase activity; GO:0015036 disulfide oxidoreductase activity; GO:0016209 antioxidant activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016667 oxidoreductase activity"," acting on a sulfur group of donors; GO:0016668 oxidoreductase activity"," acting on a sulfur group of donors"," NAD(P) as acceptor; GO:0016671 oxidoreductase activity"," acting on a sulfur group of donors"," disulfide as acceptor; GO:0047134 protein-disulfide reductase (NAD(P)) activity;","PF00085; PF06201","PF00085 Thioredoxin; PF06201 PITH domain","O","KOG0908","Thioredoxin-like protein",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013418 RHOBTB2 GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013422 RHOBTB1 GTPase cycle;R-HSA-9013424 RHOV GTPase cycle;R-HSA-9696264 RND3 GTPase cycle;R-HSA-9696270 RND2 GTPase cycle;R-HSA-9696273 RND1 GTPase cycle;R-HSA-9706574 RHOBTB GTPase Cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013418;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-9013422;https://reactome.org/PathwayBrowser/#/R-HSA-9013424;https://reactome.org/PathwayBrowser/#/R-HSA-9696264;https://reactome.org/PathwayBrowser/#/R-HSA-9696270;https://reactome.org/PathwayBrowser/#/R-HSA-9696273;https://reactome.org/PathwayBrowser/#/R-HSA-9706574;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O43399","Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2","TPD52L2",1.130139076,0.000961643,"up",71722.2,74590,73014.7,83902.2,81533.8,82433.9,0.921096206,0.957926082,0.937695207,1.07751851,1.047102206,1.058661789,"cytoplasm","nucleus",{"$nulls":3},"GO:0042127 regulation of cell population proliferation; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0048471 perinuclear region of cytoplasm;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity;",null,null,"R","KOG4010","Coiled-coil protein TPD52"]
["O43402","ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1","EMC8",0.983207794,0.714901472,"nochange",12245.6,12158.4,13339.7,13128.7,11798.5,12182.7,0.981564013,0.974574369,1.069263202,1.052350188,0.945726057,0.976522171,"extracellular","K23569",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0072546 EMC complex; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"R","KOG3289","Uncharacterized conserved protein encoded by sequence overlapping the COX4 gene"]
["O43422","52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens OX=9606 GN=THAP12 PE=1 SV=2","THAP12",1.489277899,0.003821004,"up",5627.32,6841.51,5719.77,8688.2,8993.96,9405.72,0.745727583,0.906630993,0.757978977,1.151352755,1.191871806,1.246437886,"nucleus",{"$nulls":3},"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008285 negative regulation of cell population proliferation; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0042127 regulation of cell population proliferation; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF05485; PF05699","PF05485 THAP domain; PF05699 hAT family C-terminal dimerisation region"]
["O43426","Synaptojanin-1 OS=Homo sapiens OX=9606 GN=SYNJ1 PE=1 SV=2","SYNJ1",1.206298254,0.008405797,"up",5300.35,4894.74,5512.12,6529.4,6249.74,6168.44,0.917682664,0.847456874,0.954347725,1.130475758,1.082056478,1.067980501,"cytoplasm","K20279","SYNJ; synaptojanin [EC:3.1.3.36]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0001101 response to acid chemical; GO:0001505 regulation of neurotransmitter levels; GO:0001956 positive regulation of neurotransmitter secretion; GO:0003008 system process; GO:0003012 muscle system process; GO:0005975 carbohydrate metabolic process; GO:0006066 alcohol metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006820 anion transport; GO:0006836 neurotransmitter transport; GO:0006865 amino acid transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006900 vesicle budding from membrane; GO:0006936 muscle contraction; GO:0006937 regulation of muscle contraction; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007032 endosome organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009914 hormone transport; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010817 regulation of hormone levels; GO:0010939 regulation of necrotic cell death; GO:0010940 positive regulation of necrotic cell death; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014013 regulation of gliogenesis; GO:0014015 positive regulation of gliogenesis; GO:0015695 organic cation transport; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015812 gamma-aminobutyric acid transport; GO:0015849 organic acid transport; GO:0015870 acetylcholine transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016082 synaptic vesicle priming; GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane; GO:0016191 synaptic vesicle uncoating; GO:0016192 vesicle-mediated transport; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016311 dephosphorylation; GO:0017156 calcium-ion regulated exocytosis; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0022008 neurogenesis; GO:0022411 cellular component disassembly; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023061 signal release; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030258 lipid modification; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031503 protein-containing complex localization; GO:0031623 receptor internalization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032526 response to retinoic acid; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0035418 protein localization to synapse; GO:0035556 intracellular signal transduction; GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process; GO:0036465 synaptic vesicle recycling; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0042221 response to chemical; GO:0043058 regulation of backward locomotion; GO:0043059 regulation of forward locomotion; GO:0043112 receptor metabolic process; GO:0043170 macromolecule metabolic process; GO:0043647 inositol phosphate metabolic process; GO:0043933 protein-containing complex organization; GO:0043954 cellular component maintenance; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044088 regulation of vacuole organization; GO:0044089 positive regulation of cellular component biogenesis; GO:0044090 positive regulation of vacuole organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045055 regulated exocytosis; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045807 positive regulation of endocytosis; GO:0045927 positive regulation of growth; GO:0045933 positive regulation of muscle contraction; GO:0046164 alcohol catabolic process; GO:0046174 polyol catabolic process; GO:0046434 organophosphate catabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046838 phosphorylated carbohydrate dephosphorylation; GO:0046839 phospholipid dephosphorylation; GO:0046855 inositol phosphate dephosphorylation; GO:0046856 phosphatidylinositol dephosphorylation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0046928 regulation of neurotransmitter secretion; GO:0046942 carboxylic acid transport; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048193 Golgi vesicle transport; GO:0048212 Golgi vesicle uncoating; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048488 synaptic vesicle endocytosis; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048790 maintenance of presynaptic active zone structure; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050808 synapse organization; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051261 protein depolymerization; GO:0051588 regulation of neurotransmitter transport; GO:0051590 positive regulation of neurotransmitter transport; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051668 localization within membrane; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070142 synaptic vesicle budding; GO:0071545 inositol phosphate catabolic process; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072318 clathrin coat disassembly; GO:0072319 vesicle uncoating; GO:0090257 regulation of muscle system process; GO:0090407 organophosphate biosynthetic process; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098657 import into cell; GO:0098693 regulation of synaptic vesicle cycle; GO:0098884 postsynaptic neurotransmitter receptor internalization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels; GO:0099177 regulation of trans-synaptic signaling; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099558 maintenance of synapse structure; GO:0099590 neurotransmitter receptor internalization; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:1901374 acetate ester transport; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901616 organic hydroxy compound catabolic process; GO:1901700 response to oxygen-containing compound; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1903421 regulation of synaptic vesicle recycling; GO:1903423 positive regulation of synaptic vesicle recycling; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904978 regulation of endosome organization; GO:1904980 positive regulation of endosome organization; GO:1990709 presynaptic active zone organization; GO:2000026 regulation of multicellular organismal development; GO:2000785 regulation of autophagosome assembly; GO:2000786 positive regulation of autophagosome assembly;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005767 secondary lysosome; GO:0005773 vacuole; GO:0005776 autophagosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005905 clathrin-coated pit; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030118 clathrin coat; GO:0030132 clathrin coat of coated pit; GO:0030133 transport vesicle; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0044754 autolysosome; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0048475 coated membrane; GO:0061174 type I terminal bouton; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0004438 phosphatidylinositol-3-phosphatase activity; GO:0004439 phosphatidylinositol-4","5-bisphosphate 5-phosphatase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding; GO:0034593 phosphatidylinositol bisphosphate phosphatase activity; GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity; GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity; GO:0043813 phosphatidylinositol-3","5-bisphosphate 5-phosphatase activity; GO:0044877 protein-containing complex binding; GO:0046030 inositol trisphosphate phosphatase activity; GO:0052629 phosphatidylinositol-3","5-bisphosphate 3-phosphatase activity; GO:0052658 inositol-1",4,"5-trisphosphate 5-phosphatase activity; GO:0052659 inositol-1",3,4,"5-tetrakisphosphate 5-phosphatase activity; GO:0052743 inositol tetrakisphosphate phosphatase activity; GO:0052744 phosphatidylinositol monophosphate phosphatase activity; GO:0052745 inositol phosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity; GO:0106018 phosphatidylinositol-3","5-bisphosphate phosphatase activity; GO:0106019 phosphatidylinositol-4","5-bisphosphate phosphatase activity; GO:1990175 EH domain binding;","PF03372; PF08952","PF03372 Endonuclease/Exonuclease/phosphatase family; PF08952 Domain of unknown function (DUF1866) ","U","KOG0566","Inositol-1",4,"5-triphosphate 5-phosphatase (synaptojanin)"," INP51/INP52/INP53 family","WP437 EGFEGFR SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1430728 Metabolism;R-HSA-1483249 Inositol phosphate metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-1855183 Synthesis of IP2"," IP"," and Ins in the cytosol;R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol;R-HSA-199991 Membrane Trafficking;R-HSA-556833 Metabolism of lipids;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483249;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-1855183;https://reactome.org/PathwayBrowser/#/R-HSA-1855204;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828","HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O43427","Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3","FIBP",0.583048591,0.005348318,"down",14510.2,14949.1,11624.6,8096.69,8699.19,7158.03,1.338624409,1.379114703,1.072416184,0.746952273,0.802535325,0.660357106,"cytoplasm","K26161",null,null,"GO:0002009 morphogenesis of an epithelium; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007368 determination of left/right symmetry; GO:0007389 pattern specification process; GO:0008543 fibroblast growth factor receptor signaling pathway; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009799 specification of symmetry; GO:0009855 determination of bilateral symmetry; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0042221 response to chemical; GO:0044085 cellular component biogenesis; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0044782 cilium organization; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060026 convergent extension; GO:0060271 cilium assembly; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0070121 Kupffer's vesicle development; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071774 response to fibroblast growth factor; GO:0071840 cellular component organization or biogenesis; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005488 binding; GO:0005515 protein binding; GO:0017134 fibroblast growth factor binding; GO:0019838 growth factor binding;",{"$nulls":5},"WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION","http://www.wikipathways.org/instance/WP5072_r115764"]
["O43432","Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2","EIF4G3",1.020022475,0.507309579,"nochange",12171.4,11167.5,11721.7,12056.3,12082.2,11624.1,1.03113669,0.946088287,0.993039004,1.021385648,1.023579844,0.984770527,"nucleus","K03260","EIF4G; translation initiation factor 4G","hsa05416 Viral myocarditis","GO:0000003 reproduction; GO:0000280 nuclear division; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0003006 developmental process involved in reproduction; GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007140 male meiotic nuclear division; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033043 regulation of organelle organization; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0040020 regulation of meiotic nuclear division; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045727 positive regulation of translation; GO:0045787 positive regulation of cell cycle; GO:0045836 positive regulation of meiotic nuclear division; GO:0045937 positive regulation of phosphate metabolic process; GO:0048134 germ-line cyst formation; GO:0048136 male germ-line cyst formation; GO:0048137 spermatocyte division; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051445 regulation of meiotic cell cycle; GO:0051446 positive regulation of meiotic cell cycle; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0060255 regulation of macromolecule metabolic process; GO:0060631 regulation of meiosis I; GO:0060903 positive regulation of meiosis I; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0140013 meiotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903046 meiotic cell cycle process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016281 eukaryotic translation initiation factor 4F complex; GO:0032991 protein-containing complex;","GO:0000339 RNA cap binding; GO:0000340 RNA 7-methylguanosine cap binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003743 translation initiation factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0008190 eukaryotic initiation factor 4E binding; GO:0031369 translation initiation factor binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG0401","Translation initiation factor 4F"," ribosome/mRNA-bridging subunit (eIF-4G)","WP107 TRANSLATION FACTORS;WP4566 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS","http://www.wikipathways.org/instance/WP107_r117851;http://www.wikipathways.org/instance/WP4566_r104315",null,"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-168256 Immune System;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1169408;https://reactome.org/PathwayBrowser/#/R-HSA-1169410;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-913531","ALLOGRAFT REJECTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION"]
["O43447","Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1","PPIH",1.262818292,0.000964142,"up",80469.2,82075.1,82788.7,100188,101064,108559,0.869711642,0.88706822,0.894780814,1.082832562,1.092300376,1.173306385,"cytoplasm","K09567","PPIH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0000413 protein peptidyl-prolyl isomerization; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006457 protein folding; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018193 peptidyl-amino acid modification; GO:0018208 peptidyl-proline modification; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048524 positive regulation of viral process; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005737 cytoplasm; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0046540 U4/U6 x U5 tri-snRNP complex; GO:0070013 intracellular organelle lumen; GO:0071001 U4/U6 snRNP; GO:0097525 spliceosomal snRNP complex; GO:0097526 spliceosomal tri-snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0003755 peptidyl-prolyl cis-trans isomerase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0016018 cyclosporin A binding; GO:0016853 isomerase activity; GO:0016859 cis-trans isomerase activity; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0043021 ribonucleoprotein complex binding; GO:0044877 protein-containing complex binding; GO:0140096 catalytic activity"," acting on a protein;","PF00160","PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD","O","KOG0879","U-snRNP-associated cyclophilin type peptidyl-prolyl cis-trans isomerase",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O43463","Histone-lysine N-methyltransferase SUV39H1 OS=Homo sapiens OX=9606 GN=SUV39H1 PE=1 SV=1","SUV39H1",0.868439424,0.047942341,"nochange",5671.46,5813.31,6119.44,5494.42,5098.51,4695.26,1.034547798,1.060423076,1.116265155,1.002253408,0.930034294,0.856476268,"nucleus","K11419","SUV39H; [histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]","hsa00310 Lysine degradation; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000183 rDNA heterochromatin assembly; GO:0001654 eye development; GO:0001666 response to hypoxia; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006304 DNA modification; GO:0006305 DNA alkylation; GO:0006306 DNA methylation; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008356 asymmetric cell division; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0017145 stem cell division; GO:0018022 peptidyl-lysine methylation; GO:0018023 peptidyl-lysine trimethylation; GO:0018027 peptidyl-lysine dimethylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031016 pancreas development; GO:0031017 exocrine pancreas development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031497 chromatin assembly; GO:0031507 heterochromatin assembly; GO:0032259 methylation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034968 histone lysine methylation; GO:0035272 exocrine system development; GO:0036123 histone H3-K9 dimethylation; GO:0036124 histone H3-K9 trimethylation; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0040029 regulation of gene expression"," epigenetic; GO:0042078 germ-line stem cell division; GO:0042221 response to chemical; GO:0042752 regulation of circadian rhythm; GO:0042754 negative regulation of circadian rhythm; GO:0043010 camera-type eye development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0044728 DNA methylation or demethylation; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048132 female germ-line stem cell asymmetric division; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048593 camera-type eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051567 histone H3-K9 methylation; GO:0051716 cellular response to stimulus; GO:0055123 digestive system development; GO:0060041 retina development in camera-type eye; GO:0060042 retina morphogenesis in camera-type eye; GO:0060255 regulation of macromolecule metabolic process; GO:0061647 histone H3-K9 modification; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0070828 heterochromatin organization; GO:0070887 cellular response to chemical stimulus; GO:0071103 DNA conformation change; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090596 sensory organ morphogenesis; GO:0098722 asymmetric stem cell division; GO:0098728 germline stem cell asymmetric division; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001228 regulation of response to gamma radiation; GO:2001229 negative regulation of response to gamma radiation;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005652 nuclear lamina; GO:0005654 nucleoplasm; GO:0005677 chromatin silencing complex; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005701 polytene chromosome chromocenter; GO:0010369 chromocenter; GO:0017053 transcription repressor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033553 rDNA heterochromatin; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016278 lysine N-methyltransferase activity; GO:0016279 protein-lysine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0018024 histone-lysine N-methyltransferase activity; GO:0042054 histone methyltransferase activity; GO:0043565 sequence-specific DNA binding; GO:0046974 histone methyltransferase activity (H3-K9 specific); GO:0047485 protein N-terminus binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00385","PF00385 Chromo (CHRromatin Organisation MOdifier) domain","BK","KOG1082","Histone H3 (Lys9) methyltransferase SUV39H1/Clr4"," required for transcriptional silencing","WP3594 CIRCADIAN RHYTHM GENES;WP4320 EFFECT OF PROGERIN ON GENES INVOLVED IN HUTCHINSONGILFORD PROGERIA SYNDROME;WP2369 HISTONE MODIFICATIONS;WP3670 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY;WP2446 RETINOBLASTOMA GENE IN CANCER","http://www.wikipathways.org/instance/WP3594_r117682;http://www.wikipathways.org/instance/WP4320_r116686;http://www.wikipathways.org/instance/WP2369_r118380;http://www.wikipathways.org/instance/WP3670_r117829;http://www.wikipathways.org/instance/WP2446_r116593",null,"R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-3214841 PKMTs methylate histone lysines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-427359 SIRT1 negatively regulates rRNA expression;R-HSA-4839726 Chromatin organization;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-3214841;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-427359;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5250941;https://reactome.org/PathwayBrowser/#/R-HSA-74160","E2F TARGETS;G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O43464","Serine protease HTRA2"," mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2","HTRA2",1.045148532,0.27737451,"nochange",60925.6,55685.1,59361.8,58929.6,61163.2,63824.6,1.015737313,0.928368926,0.989666006,0.982460469,1.019698524,1.064068761,"mitochondria","K08669","HTRA2; HtrA serine peptidase 2 [EC:3.4.21.108]","hsa04215 Apoptosis - multiple species; hsa04210 Apoptosis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05012 Parkinson disease","GO:0000003 reproduction; GO:0001101 response to acid chemical; GO:0003006 developmental process involved in reproduction; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0007628 adult walking behavior; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008344 adult locomotory behavior; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009628 response to abiotic stimulus; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010623 programmed cell death involved in cell development; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016241 regulation of macroautophagy; GO:0016242 negative regulation of macroautophagy; GO:0016485 protein processing; GO:0016540 protein autoprocessing; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030534 adult behavior; GO:0030900 forebrain development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032526 response to retinoic acid; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034599 cellular response to oxidative stress; GO:0034605 cellular response to heat; GO:0035234 ectopic germ cell programmed cell death; GO:0035456 response to interferon-beta; GO:0035458 cellular response to interferon-beta; GO:0035556 intracellular signal transduction; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045786 negative regulation of cell cycle; GO:0045862 positive regulation of proteolysis; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051604 protein maturation; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060548 negative regulation of cell death; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070206 protein trimerization; GO:0070207 protein homotrimerization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071300 cellular response to retinoic acid; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071363 cellular response to growth factor stimulus; GO:0071396 cellular response to lipid; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090659 walking behavior; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097194 execution phase of apoptosis; GO:0098780 response to mitochondrial depolarisation; GO:1900407 regulation of cellular response to oxidative stress; GO:1900408 negative regulation of cellular response to oxidative stress; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901524 regulation of mitophagy; GO:1901525 negative regulation of mitophagy; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902882 regulation of response to oxidative stress; GO:1902883 negative regulation of response to oxidative stress; GO:1903146 regulation of autophagy of mitochondrion; GO:1903147 negative regulation of autophagy of mitochondrion; GO:1903201 regulation of oxidative stress-induced cell death; GO:1903202 negative regulation of oxidative stress-induced cell death; GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization; GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001238 positive regulation of extrinsic apoptotic signaling pathway; GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand; GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway; GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;","GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005758 mitochondrial intermembrane space; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0016006 Nebenkern; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0035631 CD40 receptor complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043235 receptor complex; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1905286 serine-type peptidase complex; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex; GO:1905370 serine-type endopeptidase complex;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004252 serine-type endopeptidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008236 serine-type peptidase activity; GO:0016787 hydrolase activity; GO:0017171 serine hydrolase activity; GO:0042802 identical protein binding; GO:0051082 unfolded protein binding; GO:0140096 catalytic activity"," acting on a protein;","PF13365; PF17820","PF13365 Trypsin-like peptidase domain; PF17820 PDZ domain","O","KOG1320","Serine protease","WP1772 APOPTOSIS MODULATION AND SIGNALING;WP4352 CILIARY LANDSCAPE;WP5090 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY;WP2507 NANOMATERIAL INDUCED APOPTOSIS;WP2371 PARKINSONS DISEASE PATHWAY","http://www.wikipathways.org/instance/WP1772_r120736;http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP5090_r118898;http://www.wikipathways.org/instance/WP2507_r110715;http://www.wikipathways.org/instance/WP2371_r119919",{"$nulls":3},"HEME METABOLISM;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O43488","Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3","AKR7A2",0.851232991,1.128914E-3,"down",75905.9,75940.3,77105.1,66335.5,65983.9,62571.5,1.074540006,1.075026979,1.091516135,0.939059395,0.934082071,0.885775414,"mitochondria","K15303","AKR7; aflatoxin B1 aldehyde reductase","hsa00980 Metabolism of xenobiotics by cytochrome P450","GO:0005975 carbohydrate metabolic process; GO:0006066 alcohol metabolic process; GO:0006081 cellular aldehyde metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006725 cellular aromatic compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009410 response to xenobiotic stimulus; GO:0009987 cellular process; GO:0016137 glycoside metabolic process; GO:0016999 antibiotic metabolic process; GO:0019748 secondary metabolic process; GO:0022900 electron transport chain; GO:0030638 polyketide metabolic process; GO:0030647 aminoglycoside antibiotic metabolic process; GO:0034308 primary alcohol metabolic process; GO:0042180 cellular ketone metabolic process; GO:0042221 response to chemical; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0044597 daunorubicin metabolic process; GO:0044598 doxorubicin metabolic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0070887 cellular response to chemical stimulus; GO:0071466 cellular response to xenobiotic stimulus; GO:0071704 organic substance metabolic process; GO:0097164 ammonium ion metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901657 glycosyl compound metabolic process; GO:1901661 quinone metabolic process; GO:1902644 tertiary alcohol metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004032 alditol:NADP+ 1-oxidoreductase activity; GO:0004033 aldo-keto reductase (NADP) activity; GO:0004301 epoxide hydrolase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008106 alcohol dehydrogenase (NADP+) activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor; GO:0016787 hydrolase activity; GO:0016801 hydrolase activity"," acting on ether bonds; GO:0016803 ether hydrolase activity; GO:0019118 phenanthrene-epoxide hydrolase activity; GO:0019119 phenanthrene-9","10-epoxide hydrolase activity; GO:0042802 identical protein binding;","PF00248","PF00248 Aldo/keto reductase family",{"$nulls":3},"WP699 AFLATOXIN B1 METABOLISM;WP4157 GABA METABOLISM AKA GHB;WP702 METAPATHWAY BIOTRANSFORMATION PHASE I AND II","http://www.wikipathways.org/instance/WP699_r106828;http://www.wikipathways.org/instance/WP4157_r120415;http://www.wikipathways.org/instance/WP702_r106643",null,"R-HSA-1430728 Metabolism;R-HSA-211859 Biological oxidations;R-HSA-5423646 Aflatoxin activation and detoxification","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-5423646"]
["O43491","Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1","EPB41L2",0.977513749,0.320622664,"nochange",78619.5,74224.3,76398.5,76135.1,73278.3,74674.1,1.040560316,0.982388098,1.011164499,1.007678295,0.969867412,0.98834138,"nucleus","K23961",null,null,"GO:0000902 cell morphogenesis; GO:0001700 embryonic development via the syncytial blastoderm; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002175 protein localization to paranode region of axon; GO:0003002 regionalization; GO:0003007 heart morphogenesis; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003015 heart process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007009 plasma membrane organization; GO:0007010 cytoskeleton organization; GO:0007043 cell-cell junction assembly; GO:0007155 cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007272 ensheathment of neurons; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007424 open tracheal system development; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007507 heart development; GO:0007525 somatic muscle development; GO:0007527 adult somatic muscle development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008104 protein localization; GO:0008360 regulation of cell shape; GO:0008362 chitin-based embryonic cuticle biosynthetic process; GO:0008366 axon ensheathment; GO:0008544 epidermis development; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009913 epidermal cell differentiation; GO:0009954 proximal/distal pattern formation; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010256 endomembrane system organization; GO:0010927 cellular component assembly involved in morphogenesis; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0019991 septate junction assembly; GO:0021782 glial cell development; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0022612 gland morphogenesis; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030913 paranodal junction assembly; GO:0031032 actomyosin structure organization; GO:0031175 neuron projection development; GO:0032288 myelin assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032507 maintenance of protein location in cell; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034613 cellular protein localization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035150 regulation of tube size; GO:0035151 regulation of tube size"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035272 exocrine system development; GO:0035295 tube development; GO:0035315 hair cell differentiation; GO:0035316 non-sensory hair organization; GO:0035317 imaginal disc-derived wing hair organization; GO:0035321 maintenance of imaginal disc-derived wing hair orientation; GO:0040003 chitin-based cuticle development; GO:0042063 gliogenesis; GO:0042335 cuticle development; GO:0042552 myelination; GO:0042886 amide transport; GO:0043217 myelin maintenance; GO:0043297 apical junction assembly; GO:0044085 cellular component biogenesis; GO:0045184 establishment of protein localization; GO:0045185 maintenance of protein location; GO:0045216 cell-cell junction organization; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051651 maintenance of location in cell; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060562 epithelial tube morphogenesis; GO:0060856 establishment of blood-brain barrier; GO:0060857 establishment of glial blood-brain barrier; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0061343 cell adhesion involved in heart morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071205 protein localization to juxtaparanode region of axon; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0090066 regulation of anatomical structure size; GO:0090150 establishment of protein localization to membrane; GO:0099612 protein localization to axon; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1903829 positive regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904377 positive regulation of protein localization to cell periphery; GO:1904776 regulation of protein localization to cell cortex; GO:1904778 positive regulation of protein localization to cell cortex; GO:1990778 protein localization to cell periphery;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005918 septate junction; GO:0005920 smooth septate junction; GO:0005938 cell cortex; GO:0008091 spectrin; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030054 cell junction; GO:0030424 axon; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0033270 paranode region of axon; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043296 apical junction complex; GO:0044224 juxtaparanode region of axon; GO:0044304 main axon; GO:0070013 intracellular organelle lumen; GO:0070160 tight junction; GO:0071944 cell periphery; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0019904 protein domain specific binding; GO:0030507 spectrin binding; GO:0042731 PH domain binding;","PF09379; PF00373; PF09380; PF04382","PF09379 FERM N-terminal domain ; PF00373 FERM central domain; PF09380 FERM C-terminal PH-like domain; PF04382 SAB domain","R","KOG3530","FERM domain protein EHM2","WP4148 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS","http://www.wikipathways.org/instance/WP4148_r110682",null,"R-HSA-112316 Neuronal System;R-HSA-6794361 Neurexins and neuroligins;R-HSA-6794362 Protein-protein interactions at synapses","https://reactome.org/PathwayBrowser/#/R-HSA-112316;https://reactome.org/PathwayBrowser/#/R-HSA-6794361;https://reactome.org/PathwayBrowser/#/R-HSA-6794362","APICAL JUNCTION;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O43493","Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4","TGOLN2",0.968854321,0.835086768,"nochange",2099.29,2460.46,3004.06,2931.12,1917.15,2479.96,0.84580353,0.991318852,1.210335186,1.180947674,0.77241936,0.999175398,"extracellular",{"$nulls":3},"GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006895 Golgi to endosome transport; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016482 cytosolic transport; GO:0019538 protein metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061024 membrane organization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:1901564 organonitrogen compound metabolic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005802 trans-Golgi network; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030140 trans-Golgi network transport vesicle; GO:0030659 cytoplasmic vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030665 clathrin-coated vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;",{"$nulls":9},"R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);R-HSA-392499 Metabolism of proteins;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-8957275 Post-translational protein phosphorylation","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-381426;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-8957275"]
["O43502","DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1","RAD51C",0.559152397,0.002657307,"down",7108.16,6943.01,7212.55,3528.93,4679.88,3680.85,1.286413633,1.256525277,1.305305824,0.638655244,0.846950748,0.666149273,"mitochondria","K10870","RAD51L2; RAD51-like protein 2","hsa03460 Fanconi anemia pathway; hsa03440 Homologous recombination","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000280 nuclear division; GO:0000707 meiotic DNA recombinase assembly; GO:0000722 telomere maintenance via recombination; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000730 DNA recombinase assembly; GO:0000819 sister chromatid segregation; GO:0001709 cell fate determination; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006312 mitotic recombination; GO:0006403 RNA localization; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007062 sister chromatid cohesion; GO:0007066 female meiosis sister chromatid cohesion; GO:0007127 meiosis I; GO:0007131 reciprocal meiotic recombination; GO:0007135 meiosis II; GO:0007140 male meiotic nuclear division; GO:0007141 male meiosis I; GO:0007143 female meiotic nuclear division; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007294 germarium-derived oocyte fate determination; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008152 metabolic process; GO:0008298 intracellular mRNA localization; GO:0009314 response to radiation; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009888 tissue development; GO:0009948 anterior/posterior axis specification; GO:0009949 polarity specification of anterior/posterior axis; GO:0009950 dorsal/ventral axis specification; GO:0009951 polarity specification of dorsal/ventral axis; GO:0009952 anterior/posterior pattern specification; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010212 response to ionizing radiation; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010564 regulation of cell cycle process; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010971 positive regulation of G2/M transition of mitotic cell cycle; GO:0016043 cellular component organization; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030703 eggshell formation; GO:0030706 germarium-derived oocyte differentiation; GO:0030707 ovarian follicle cell development; GO:0030716 oocyte fate determination; GO:0030717 oocyte karyosome formation; GO:0030720 oocyte localization involved in germarium-derived egg chamber formation; GO:0030855 epithelial cell differentiation; GO:0031023 microtubule organizing center organization; GO:0032200 telomere organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0035825 homologous recombination; GO:0042060 wound healing; GO:0042148 strand invasion; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045003 double-strand break repair via synthesis-dependent strand annealing; GO:0045132 meiotic chromosome segregation; GO:0045144 meiotic sister chromatid segregation; GO:0045165 cell fate commitment; GO:0045787 positive regulation of cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0046843 dorsal appendage formation; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051177 meiotic sister chromatid cohesion; GO:0051179 localization; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051641 cellular localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060249 anatomical structure homeostasis; GO:0060429 epithelium development; GO:0061982 meiosis I cell cycle process; GO:0061983 meiosis II cell cycle process; GO:0061988 karyosome formation; GO:0065001 specification of axis polarity; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090735 DNA repair complex assembly; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902751 positive regulation of cell cycle G2/M phase transition; GO:1903046 meiotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0030054 cell junction; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033061 DNA recombinase mediator complex; GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex; GO:0033065 Rad51C-XRCC3 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0048476 Holliday junction resolvase complex; GO:0070013 intracellular organelle lumen;","GO:0000150 DNA strand exchange activity; GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003697 single-stranded DNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0004520 endodeoxyribonuclease activity; GO:0004536 deoxyribonuclease activity; GO:0005488 binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0008821 crossover junction endodeoxyribonuclease activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0016889 endodeoxyribonuclease activity"," producing 3'-phosphomonoesters; GO:0016894 endonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding;","PF08423","PF08423 Rad51","DL","KOG1434","Meiotic recombination protein Dmc1","WP4946 DNA REPAIR PATHWAYS FULL NETWORK","http://www.wikipathways.org/instance/WP4946_r117703",null,"R-HSA-109582 Hemostasis;R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693537 Resolution of D-Loop Structures;R-HSA-5693538 Homology Directed Repair;R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates;R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-73894 DNA Repair;R-HSA-912446 Meiotic recombination;R-HSA-9675135 Diseases of DNA repair;R-HSA-9675136 Diseases of DNA Double-Strand Break Repair;R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function;R-HSA-9701192 Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function;R-HSA-9701193 Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function;R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function;R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function;R-HSA-9709603 Impaired BRCA2 binding to PALB2;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1474165;https://reactome.org/PathwayBrowser/#/R-HSA-1500620;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-5685942;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693537;https://reactome.org/PathwayBrowser/#/R-HSA-5693538;https://reactome.org/PathwayBrowser/#/R-HSA-5693554;https://reactome.org/PathwayBrowser/#/R-HSA-5693567;https://reactome.org/PathwayBrowser/#/R-HSA-5693568;https://reactome.org/PathwayBrowser/#/R-HSA-5693579;https://reactome.org/PathwayBrowser/#/R-HSA-5693616;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-912446;https://reactome.org/PathwayBrowser/#/R-HSA-9675135;https://reactome.org/PathwayBrowser/#/R-HSA-9675136;https://reactome.org/PathwayBrowser/#/R-HSA-9701190;https://reactome.org/PathwayBrowser/#/R-HSA-9701192;https://reactome.org/PathwayBrowser/#/R-HSA-9701193;https://reactome.org/PathwayBrowser/#/R-HSA-9704331;https://reactome.org/PathwayBrowser/#/R-HSA-9704646;https://reactome.org/PathwayBrowser/#/R-HSA-9709603;https://reactome.org/PathwayBrowser/#/R-HSA-983231","E2F TARGETS;P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O43504","Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1","LAMTOR5",0.864153345,0.265736559,"nochange",5310.41,6308.5,5667.64,5867.52,4030.71,5040,0.988756479,1.174592969,1.055269889,1.092485969,0.750486427,0.938408268,"cytoskeleton","K16344","LAMTOR5; ragulator complex protein LAMTOR5","hsa04150 mTOR signaling pathway","GO:0001101 response to acid chemical; GO:0008104 protein localization; GO:0008361 regulation of cell size; GO:0009719 response to endogenous stimulus; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010466 negative regulation of peptidase activity; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010951 negative regulation of endopeptidase activity; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0032006 regulation of TOR signaling; GO:0032008 positive regulation of TOR signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032535 regulation of cellular component size; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043200 response to amino acid; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0044092 negative regulation of molecular function; GO:0045861 negative regulation of proteolysis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061462 protein localization to lysosome; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071230 cellular response to amino acid stimulus; GO:0071310 cellular response to organic substance; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071840 cellular component organization or biogenesis; GO:0072665 protein localization to vacuole; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045121 membrane raft; GO:0071986 Ragulator complex; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098857 membrane microdomain;",null,"PF16672","PF16672 Ragulator complex protein LAMTOR5",{"$nulls":6},"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-1632852 Macroautophagy;R-HSA-165159 MTOR signalling;R-HSA-166208 mTORC1-mediated signalling;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK;R-HSA-5628897 TP53 Regulates Metabolic Genes;R-HSA-6807070 PTEN Regulation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8943724 Regulation of PTEN gene transcription;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9612973 Autophagy;R-HSA-9639288 Amino acids regulate mTORC1;R-HSA-9711097 Cellular response to starvation","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-165159;https://reactome.org/PathwayBrowser/#/R-HSA-166208;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-380972;https://reactome.org/PathwayBrowser/#/R-HSA-5628897;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8943724;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9639288;https://reactome.org/PathwayBrowser/#/R-HSA-9711097","REACTIVE OXYGEN SPECIES PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"]
["O43516","WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3","WIPF1",0.885082726,0.009018455,"down",100007,96363.6,95509.8,85948.5,89417.4,82972.4,1.090551811,1.050821428,1.041510948,0.937247316,0.97507482,0.904793676,"nucleus","K19475","WIPF; WAS/WASL-interacting protein","hsa05130 Pathogenic Escherichia coli infection; hsa04144 Endocytosis; hsa05135 Yersinia infection","GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008154 actin polymerization or depolymerization; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033157 regulation of intracellular protein transport; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046825 regulation of protein export from nucleus; GO:0046827 positive regulation of protein export from nucleus; GO:0048518 positive regulation of biological process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0060341 regulation of cellular localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0071840 cellular component organization or biogenesis; GO:0090087 regulation of peptide transport; GO:0090316 positive regulation of intracellular protein transport; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:1903829 positive regulation of protein localization; GO:1904951 positive regulation of establishment of protein localization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0015629 actin cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005522 profilin binding; GO:0008092 cytoskeletal protein binding; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding;",null,null,"Z","KOG4462","WASP-interacting protein VRP1/WIP"," contains WH2 domain",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663213;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","EPITHELIAL MESENCHYMAL TRANSITION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"]
["O43524","Forkhead box protein O3 OS=Homo sapiens OX=9606 GN=FOXO3 PE=1 SV=1","FOXO3",1.348021296,0.027063918,"nochange",4005.61,3383.19,4562.71,5424.44,5134.18,5552.27,0.85643637,0.723357232,0.97554949,1.159795313,1.097735048,1.187126547,"nucleus","K09408","FOXO3; forkhead box protein O3","hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa01521 EGFR tyrosine kinase inhibitor resistance; hsa05131 Shigellosis; hsa04917 Prolactin signaling pathway; hsa04211 Longevity regulating pathway; hsa04137 Mitophagy - animal; hsa04213 Longevity regulating pathway - multiple species; hsa04152 AMPK signaling pathway; hsa04062 Chemokine signaling pathway; hsa04936 Alcoholic liver disease; hsa05223 Non-small cell lung cancer; hsa05213 Endometrial cancer; hsa04722 Neurotrophin signaling pathway; hsa04218 Cellular senescence; hsa04151 PI3K-Akt signaling pathway; hsa04068 FoxO signaling pathway","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000226 microtubule cytoskeleton organization; GO:0000768 syncytium formation by plasma membrane fusion; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0000959 mitochondrial RNA metabolic process; GO:0001541 ovarian follicle development; GO:0001542 ovulation from ovarian follicle; GO:0001544 initiation of primordial ovarian follicle growth; GO:0001547 antral ovarian follicle growth; GO:0001556 oocyte maturation; GO:0001558 regulation of cell growth; GO:0001578 microtubule bundle formation; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002819 regulation of adaptive immune response; GO:0002821 positive regulation of adaptive immune response; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0005975 carbohydrate metabolic process; GO:0005976 polysaccharide metabolic process; GO:0005977 glycogen metabolic process; GO:0006066 alcohol metabolic process; GO:0006073 cellular glucan metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006112 energy reserve metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006390 mitochondrial transcription; GO:0006417 regulation of translation; GO:0006629 lipid metabolic process; GO:0006694 steroid biosynthetic process; GO:0006697 ecdysone biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006949 syncytium formation; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006974 cellular response to DNA damage stimulus; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007520 myoblast fusion; GO:0007525 somatic muscle development; GO:0007548 sex differentiation; GO:0007568 aging; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007614 short-term memory; GO:0007622 rhythmic behavior; GO:0007623 circadian rhythm; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008205 ecdysone metabolic process; GO:0008219 cell death; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008285 negative regulation of cell population proliferation; GO:0008286 insulin receptor signaling pathway; GO:0008340 determination of adult lifespan; GO:0008361 regulation of cell size; GO:0008406 gonad development; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0008585 female gonad development; GO:0008593 regulation of Notch signaling pathway; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009266 response to temperature stimulus; GO:0009267 cellular response to starvation; GO:0009314 response to radiation; GO:0009408 response to heat; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010286 heat acclimation; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010817 regulation of hormone levels; GO:0010883 regulation of lipid storage; GO:0010888 negative regulation of lipid storage; GO:0010896 regulation of triglyceride catabolic process; GO:0010898 positive regulation of triglyceride catabolic process; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0014902 myotube differentiation; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016125 sterol metabolic process; GO:0016126 sterol biosynthetic process; GO:0016241 regulation of macroautophagy; GO:0016358 dendrite development; GO:0018130 heterocycle biosynthetic process; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022602 ovulation cycle process; GO:0022611 dormancy process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030308 negative regulation of cell growth; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0030718 germ-line stem cell population maintenance; GO:0030728 ovulation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032774 RNA biosynthetic process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032925 regulation of activin receptor signaling pathway; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033209 tumor necrosis factor-mediated signaling pathway; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0034097 response to cytokine; GO:0034198 cellular response to amino acid starvation; GO:0034248 regulation of cellular amide metabolic process; GO:0034599 cellular response to oxidative stress; GO:0034605 cellular response to heat; GO:0034612 response to tumor necrosis factor; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034754 cellular hormone metabolic process; GO:0035206 regulation of hemocyte proliferation; GO:0035556 intracellular signal transduction; GO:0036099 female germ-line stem cell population maintenance; GO:0038034 signal transduction in absence of ligand; GO:0040007 growth; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0040015 negative regulation of multicellular organism growth; GO:0040024 dauer larval development; GO:0042127 regulation of cell population proliferation; GO:0042180 cellular ketone metabolic process; GO:0042181 ketone biosynthetic process; GO:0042221 response to chemical; GO:0042445 hormone metabolic process; GO:0042446 hormone biosynthetic process; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042594 response to starvation; GO:0042692 muscle cell differentiation; GO:0042698 ovulation cycle; GO:0042742 defense response to bacterium; GO:0042770 signal transduction in response to DNA damage; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043434 response to peptide hormone; GO:0043523 regulation of neuron apoptotic process; GO:0043525 positive regulation of neuron apoptotic process; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0044042 glucan metabolic process; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044264 cellular polysaccharide metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045087 innate immune response; GO:0045137 development of primary sexual characteristics; GO:0045455 ecdysteroid metabolic process; GO:0045456 ecdysteroid biosynthetic process; GO:0045475 locomotor rhythm; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045639 positive regulation of myeloid cell differentiation; GO:0045646 regulation of erythrocyte differentiation; GO:0045648 positive regulation of erythrocyte differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045745 positive regulation of G protein-coupled receptor signaling pathway; GO:0045746 negative regulation of Notch signaling pathway; GO:0045787 positive regulation of cell cycle; GO:0045792 negative regulation of cell size; GO:0045834 positive regulation of lipid metabolic process; GO:0045887 positive regulation of synaptic assembly at neuromuscular junction; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046165 alcohol biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046545 development of primary female sexual characteristics; GO:0046620 regulation of organ growth; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0046660 female sex differentiation; GO:0046890 regulation of lipid biosynthetic process; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048511 rhythmic process; GO:0048512 circadian behavior; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048520 positive regulation of behavior; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048580 regulation of post-embryonic development; GO:0048582 positive regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048589 developmental growth; GO:0048592 eye morphogenesis; GO:0048599 oocyte development; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048854 brain morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050829 defense response to Gram-negative bacterium; GO:0050830 defense response to Gram-positive bacterium; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0050994 regulation of lipid catabolic process; GO:0050996 positive regulation of lipid catabolic process; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0055115 entry into diapause; GO:0055116 entry into reproductive diapause; GO:0060255 regulation of macromolecule metabolic process; GO:0060259 regulation of feeding behavior; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060537 muscle tissue development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0061061 muscle structure development; GO:0061062 regulation of nematode larval development; GO:0061063 positive regulation of nematode larval development; GO:0061065 regulation of dauer larval development; GO:0061066 positive regulation of dauer larval development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070344 regulation of fat cell proliferation; GO:0070345 negative regulation of fat cell proliferation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071356 cellular response to tumor necrosis factor; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071695 anatomical structure maturation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0090068 positive regulation of cell cycle process; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090207 regulation of triglyceride metabolic process; GO:0090208 positive regulation of triglyceride metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090596 sensory organ morphogenesis; GO:0097150 neuronal stem cell population maintenance; GO:0097190 apoptotic signaling pathway; GO:0097191 extrinsic apoptotic signaling pathway; GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand; GO:0097659 nucleic acid-templated transcription; GO:0098542 defense response to other organism; GO:0098727 maintenance of cell number; GO:0099177 regulation of trans-synaptic signaling; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140053 mitochondrial gene expression; GO:1900073 regulation of neuromuscular synaptic transmission; GO:1900075 positive regulation of neuromuscular synaptic transmission; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1900407 regulation of cellular response to oxidative stress; GO:1900409 positive regulation of cellular response to oxidative stress; GO:1900424 regulation of defense response to bacterium; GO:1900426 positive regulation of defense response to bacterium; GO:1901031 regulation of response to reactive oxygen species; GO:1901033 positive regulation of response to reactive oxygen species; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death; GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902652 secondary alcohol metabolic process; GO:1902653 secondary alcohol biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902882 regulation of response to oxidative stress; GO:1902884 positive regulation of response to oxidative stress; GO:1903201 regulation of oxidative stress-induced cell death; GO:1903205 regulation of hydrogen peroxide-induced cell death; GO:1903209 positive regulation of oxidative stress-induced cell death; GO:1903426 regulation of reactive oxygen species biosynthetic process; GO:1903428 positive regulation of reactive oxygen species biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1904035 regulation of epithelial cell apoptotic process; GO:1904037 positive regulation of epithelial cell apoptotic process; GO:1904396 regulation of neuromuscular junction development; GO:1904398 positive regulation of neuromuscular junction development; GO:1905206 positive regulation of hydrogen peroxide-induced cell death; GO:1905909 regulation of dauer entry; GO:1905952 regulation of lipid localization; GO:1905953 negative regulation of lipid localization; GO:1990928 response to amino acid starvation; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000125 regulation of octopamine or tyramine signaling pathway; GO:2000127 positive regulation of octopamine or tyramine signaling pathway; GO:2000128 regulation of octopamine signaling pathway; GO:2000130 positive regulation of octopamine signaling pathway; GO:2000177 regulation of neural precursor cell proliferation; GO:2000253 positive regulation of feeding behavior; GO:2000351 regulation of endothelial cell apoptotic process; GO:2000353 positive regulation of endothelial cell apoptotic process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process; GO:2001023 regulation of response to drug; GO:2001025 positive regulation of response to drug; GO:2001038 regulation of cellular response to drug; GO:2001040 positive regulation of cellular response to drug; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005829 cytosol; GO:0016020 membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001221 transcription coregulator binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0002020 protease binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008134 transcription factor binding; GO:0017151 DEAD/H-box RNA helicase binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0031490 chromatin DNA binding; GO:0031625 ubiquitin protein ligase binding; GO:0034246 mitochondrial transcription factor activity; GO:0043565 sequence-specific DNA binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0071889 14-3-3 protein binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990381 ubiquitin-specific protease binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00250; PF16676","PF00250 Forkhead domain; PF16676 Transactivation domain of FOXO protein family","K","KOG2294","Transcription factor of the Forkhead/HNF3 family","WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP3929 CHEMOKINE SIGNALING PATHWAY;WP3286 COPPER HOMEOSTASIS;WP710 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT;WP4806 EGFR TYROSINE KINASE INHIBITOR RESISTANCE;WP4155 ENDOMETRIAL CANCER;WP1541 ENERGY METABOLISM;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP2261 GLIOBLASTOMA SIGNALING PATHWAYS;WP3657 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHABETA COMPLEX;WP49 IL2 SIGNALING PATHWAY;WP127 IL5 SIGNALING PATHWAY;WP3640 IMATINIB AND CHRONIC MYELOID LEUKEMIA;WP481 INSULIN SIGNALING;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP4542 LEUKOCYTEINTRINSIC HIPPO PATHWAY FUNCTIONS;WP3630 NAD METABOLISM SIRTUINS AND AGING;WP4255 NONSMALL CELL LUNG CANCER;WP3651 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA;WP4172 PI3KAKT SIGNALING PATHWAY;WP3844 PI3KAKTMTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES;WP2431 SPINAL CORD INJURY;WP5098 TCELL ACTIVATION SARSCOV2;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP3929_r119247;http://www.wikipathways.org/instance/WP3286_r106367;http://www.wikipathways.org/instance/WP710_r116542;http://www.wikipathways.org/instance/WP4806_r116801;http://www.wikipathways.org/instance/WP4155_r119086;http://www.wikipathways.org/instance/WP1541_r117711;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP2261_r118379;http://www.wikipathways.org/instance/WP3657_r120797;http://www.wikipathways.org/instance/WP49_r120703;http://www.wikipathways.org/instance/WP127_r120669;http://www.wikipathways.org/instance/WP3640_r117152;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP4542_r120673;http://www.wikipathways.org/instance/WP3630_r118942;http://www.wikipathways.org/instance/WP4255_r119279;http://www.wikipathways.org/instance/WP3651_r116547;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP3844_r107714;http://www.wikipathways.org/instance/WP2431_r117177;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP3888_r116782","Transcription factor","R-HSA-1181150 Signaling by NODAL;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-198693 AKT phosphorylates targets in the nucleus;R-HSA-212436 Generic Transcription Pathway;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-449147 Signaling by Interleukins;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;R-HSA-8863678 Neurodegenerative Diseases;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8939211 ESR-mediated signaling;R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9009391 Extra-nuclear estrogen signaling;R-HSA-9607240 FLT3 Signaling;R-HSA-9614085 FOXO-mediated transcription;R-HSA-9614399 Regulation of localization of FOXO transcription factors;R-HSA-9614657 FOXO-mediated transcription of cell death genes;R-HSA-9615017 FOXO-mediated transcription of oxidative stress"," metabolic and neuronal genes;R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation;R-HSA-9617828 FOXO-mediated transcription of cell cycle genes;R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling;R-HSA-9645723 Diseases of programmed cell death;R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis","https://reactome.org/PathwayBrowser/#/R-HSA-1181150;https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-198693;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2219528;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-5674400;https://reactome.org/PathwayBrowser/#/R-HSA-5683057;https://reactome.org/PathwayBrowser/#/R-HSA-5687128;https://reactome.org/PathwayBrowser/#/R-HSA-6785807;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8862803;https://reactome.org/PathwayBrowser/#/R-HSA-8863678;https://reactome.org/PathwayBrowser/#/R-HSA-8878159;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-8952158;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9009391;https://reactome.org/PathwayBrowser/#/R-HSA-9607240;https://reactome.org/PathwayBrowser/#/R-HSA-9614085;https://reactome.org/PathwayBrowser/#/R-HSA-9614399;https://reactome.org/PathwayBrowser/#/R-HSA-9614657;https://reactome.org/PathwayBrowser/#/R-HSA-9615017;https://reactome.org/PathwayBrowser/#/R-HSA-9617629;https://reactome.org/PathwayBrowser/#/R-HSA-9617828;https://reactome.org/PathwayBrowser/#/R-HSA-9634638;https://reactome.org/PathwayBrowser/#/R-HSA-9645723;https://reactome.org/PathwayBrowser/#/R-HSA-9734009","HEME METABOLISM;HYPOXIA;P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O43542","DNA repair protein XRCC3 OS=Homo sapiens OX=9606 GN=XRCC3 PE=1 SV=1","XRCC3",0.380423256,{"v":9.38913e-05,"d":"9.39E-05"},"down",6218.22,5974.33,6657.98,2607.79,2389.23,2174.16,1.433776643,1.377541291,1.535175052,0.60129561,0.550900767,0.501310636,"mitochondria","K10880","XRCC3; DNA-repair protein XRCC3","hsa03440 Homologous recombination","GO:0000003 reproduction; GO:0000280 nuclear division; GO:0000707 meiotic DNA recombinase assembly; GO:0000722 telomere maintenance via recombination; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000730 DNA recombinase assembly; GO:0001325 formation of extrachromosomal circular DNA; GO:0001709 cell fate determination; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006312 mitotic recombination; GO:0006323 DNA packaging; GO:0006403 RNA localization; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007088 regulation of mitotic nuclear division; GO:0007127 meiosis I; GO:0007131 reciprocal meiotic recombination; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007294 germarium-derived oocyte fate determination; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0008152 metabolic process; GO:0008298 intracellular mRNA localization; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009889 regulation of biosynthetic process; GO:0009948 anterior/posterior axis specification; GO:0009949 polarity specification of anterior/posterior axis; GO:0009950 dorsal/ventral axis specification; GO:0009951 polarity specification of dorsal/ventral axis; GO:0009952 anterior/posterior pattern specification; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010212 response to ionizing radiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010824 regulation of centrosome duplication; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030154 cell differentiation; GO:0030261 chromosome condensation; GO:0030706 germarium-derived oocyte differentiation; GO:0030716 oocyte fate determination; GO:0030717 oocyte karyosome formation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032200 telomere organization; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032886 regulation of microtubule-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033554 cellular response to stress; GO:0034248 regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0035825 homologous recombination; GO:0036297 interstrand cross-link repair; GO:0042148 strand invasion; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045003 double-strand break repair via synthesis-dependent strand annealing; GO:0045165 cell fate commitment; GO:0045787 positive regulation of cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0046605 regulation of centrosome cycle; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051493 regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0061982 meiosis I cell cycle process; GO:0061988 karyosome formation; GO:0065001 specification of axis polarity; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0071103 DNA conformation change; GO:0071139 resolution of recombination intermediates; GO:0071140 resolution of mitotic recombination intermediates; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090231 regulation of spindle checkpoint; GO:0090232 positive regulation of spindle checkpoint; GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint; GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint; GO:0090304 nucleic acid metabolic process; GO:0090656 t-circle formation; GO:0090657 telomeric loop disassembly; GO:0090735 DNA repair complex assembly; GO:0090737 telomere maintenance via telomere trimming; GO:0140013 meiotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1901976 regulation of cell cycle checkpoint; GO:1901978 positive regulation of cell cycle checkpoint; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1903046 meiotic cell cycle process; GO:1903504 regulation of mitotic spindle checkpoint; GO:1905818 regulation of chromosome separation; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000781 chromosome"," telomeric region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033061 DNA recombinase mediator complex; GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex; GO:0033065 Rad51C-XRCC3 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0000150 DNA strand exchange activity; GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003697 single-stranded DNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding;","PF08423","PF08423 Rad51","L","KOG1564","DNA repair protein RHP57","WP1601 FLUOROPYRIMIDINE ACTIVITY;WP4673 MALE INFERTILITY","http://www.wikipathways.org/instance/WP1601_r120496;http://www.wikipathways.org/instance/WP4673_r119920","Transcription factor","R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693537 Resolution of D-Loop Structures;R-HSA-5693538 Homology Directed Repair;R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates;R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-5685942;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693537;https://reactome.org/PathwayBrowser/#/R-HSA-5693538;https://reactome.org/PathwayBrowser/#/R-HSA-5693554;https://reactome.org/PathwayBrowser/#/R-HSA-5693567;https://reactome.org/PathwayBrowser/#/R-HSA-5693568;https://reactome.org/PathwayBrowser/#/R-HSA-5693579;https://reactome.org/PathwayBrowser/#/R-HSA-73894","ESTROGEN RESPONSE LATE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE"]
["O43561","Linker for activation of T-cells family member 1 OS=Homo sapiens OX=9606 GN=LAT PE=1 SV=1","LAT",1.242696753,0.047319715,"nochange",8468.96,6844.07,8572.58,9916.65,9403.32,10362.6,0.948581042,0.766582326,0.960187186,1.110732155,1.053235708,1.160681584,"extracellular","K07362","LAT; linker for activation of T cells","hsa04666 Fc gamma R-mediated phagocytosis; hsa04014 Ras signaling pathway; hsa04664 Fc epsilon RI signaling pathway; hsa04658 Th1 and Th2 cell differentiation; hsa04650 Natural killer cell mediated cytotoxicity; hsa04659 Th17 cell differentiation; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04064 NF-kappa B signaling pathway; hsa04015 Rap1 signaling pathway; hsa04660 T cell receptor signaling pathway; hsa05135 Yersinia infection","GO:0000165 MAPK cascade; GO:0001775 cell activation; GO:0001776 leukocyte homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002253 activation of immune response; GO:0002260 lymphocyte homeostasis; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006968 cellular defense response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0008152 metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016310 phosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019722 calcium-mediated signaling; GO:0019932 second-messenger-mediated signaling; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0033674 positive regulation of kinase activity; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0038093 Fc receptor signaling pathway; GO:0038095 Fc-epsilon receptor signaling pathway; GO:0042110 T cell activation; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045321 leukocyte activation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046649 lymphocyte activation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048872 homeostasis of number of cells; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0001772 immunological synapse; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005911 cell-cell junction; GO:0008180 COP9 signalosome; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030054 cell junction; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045121 membrane raft; GO:0071944 cell periphery; GO:0098857 membrane microdomain;","GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030674 protein-macromolecule adaptor activity; GO:0031267 small GTPase binding; GO:0035591 signaling adaptor activity; GO:0051020 GTPase binding; GO:0060090 molecular adaptor activity; GO:0098772 molecular function regulator;",{"$nulls":5},"WP4950 16P112 DISTAL DELETION SYNDROME;WP3937 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY;WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION;WP4223 RAS SIGNALING;WP5098 TCELL ACTIVATION SARSCOV2;WP3863 TCELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4950_r115784;http://www.wikipathways.org/instance/WP3937_r120792;http://www.wikipathways.org/instance/WP5072_r115764;http://www.wikipathways.org/instance/WP4223_r119284;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP3863_r120420;http://www.wikipathways.org/instance/WP69_r120700",null,"R-HSA-109582 Hemostasis;R-HSA-114604 GPVI-mediated activation cascade;R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-202403 TCR signaling;R-HSA-202433 Generation of second messenger molecules;R-HSA-76002 Platelet activation"," signaling and aggregation","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114604;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-202403;https://reactome.org/PathwayBrowser/#/R-HSA-202433;https://reactome.org/PathwayBrowser/#/R-HSA-76002"]
["O43566","Regulator of G-protein signaling 14 OS=Homo sapiens OX=9606 GN=RGS14 PE=1 SV=4","RGS14",1.017263276,0.771083616,"nochange",9282.55,9941.04,11634.4,10136,10656.4,10598.3,0.894722443,0.958192694,1.121411551,0.976984415,1.027144507,1.021544389,"nucleus","K17706","RGS14; regulator of G-protein signaling 14","hsa04015 Rap1 signaling pathway","GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0003008 system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006469 negative regulation of protein kinase activity; GO:0006810 transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007059 chromosome segregation; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007613 memory; GO:0007616 long-term memory; GO:0007632 visual behavior; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008306 associative learning; GO:0008356 asymmetric cell division; GO:0008542 visual learning; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010070 zygote asymmetric cell division; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031914 negative regulation of synaptic plasticity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0033673 negative regulation of kinase activity; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045744 negative regulation of G protein-coupled receptor signaling pathway; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046907 intracellular transport; GO:0048008 platelet-derived growth factor receptor signaling pathway; GO:0048167 regulation of synaptic plasticity; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051301 cell division; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051348 negative regulation of transferase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060291 long-term synaptic potentiation; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070373 negative regulation of ERK1 and ERK2 cascade; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0099177 regulation of trans-synaptic signaling; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0014069 postsynaptic density; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016604 nuclear body; GO:0030425 dendrite; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032279 asymmetric synapse; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044309 neuron spine; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection;","GO:0001965 G-protein alpha-subunit binding; GO:0005092 GDP-dissociation inhibitor activity; GO:0005096 GTPase activator activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030159 signaling receptor complex adaptor activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0032794 GTPase activating protein binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00615; PF02196","PF00615 Regulator of G protein signaling domain; PF02196 Raf-like Ras-binding domain","T","KOG3589","G protein signaling regulators","WP536 CALCIUM REGULATION IN CARDIAC CELLS;WP289 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS","http://www.wikipathways.org/instance/WP536_r116854;http://www.wikipathways.org/instance/WP289_r120734",null,"R-HSA-162582 Signal Transduction;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-418594 G alpha (i) signalling events","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-418594"]
["O43567","E3 ubiquitin-protein ligase RNF13 OS=Homo sapiens OX=9606 GN=RNF13 PE=1 SV=1","RNF13",0.990308289,0.830363273,"nochange",3455.05,3498.93,3686.04,3066.07,4742.59,2728.24,0.978910059,0.991342462,1.044355836,0.868701398,1.343705317,0.772984929,"extracellular","K15692",null,null,"GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051865 protein autoubiquitination; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005637 nuclear inner membrane; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF13639","PF13639 Ring finger domain","O","KOG4628","Predicted E3 ubiquitin ligase"]
["O43572","A-kinase anchor protein 10"," mitochondrial OS=Homo sapiens OX=9606 GN=AKAP10 PE=1 SV=2","AKAP10",0.764823614,0.031723867,"nochange",8481.71,6604.72,8136.82,5772.5,6214.09,5775.1,1.241681945,0.966899549,1.191191691,0.845066505,0.909713178,0.845447133,"nucleus","K16526",null,null,"GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008104 protein localization; GO:0009611 response to wounding; GO:0009987 cellular process; GO:0023052 signaling; GO:0032501 multicellular organismal process; GO:0033036 macromolecule localization; GO:0042060 wound healing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0005488 binding; GO:0005515 protein binding; GO:0051018 protein kinase A binding;","PF00615","PF00615 Regulator of G protein signaling domain","T","KOG3590","Protein kinase A anchoring protein","WP35 G PROTEIN SIGNALING PATHWAYS","http://www.wikipathways.org/instance/WP35_r117729",null,"R-HSA-109582 Hemostasis;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-983231","COMPLEMENT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT"]
["O43583","Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2","DENR",1.133789099,0.072329751,"nochange",84719,76208,88455.8,95918.2,89178.9,97650.4,0.955243481,0.859278263,0.997377522,1.08151932,1.005530788,1.101050626,"cytoplasm","K24272",null,null,"GO:0001731 formation of translation preinitiation complex; GO:0002181 cytoplasmic translation; GO:0002183 cytoplasmic translational initiation; GO:0002188 translation reinitiation; GO:0002190 cap-independent translational initiation; GO:0002192 IRES-dependent translational initiation of linear mRNA; GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0014070 response to organic cyclic compound; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0019080 viral gene expression; GO:0019081 viral translation; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032790 ribosome disassembly; GO:0032870 cellular response to hormone stimulus; GO:0032984 protein-containing complex disassembly; GO:0032988 ribonucleoprotein complex disassembly; GO:0033993 response to lipid; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035075 response to ecdysone; GO:0035076 ecdysone receptor-mediated signaling pathway; GO:0036314 response to sterol; GO:0036315 cellular response to sterol; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045727 positive regulation of translation; GO:0045948 positive regulation of translational initiation; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046628 positive regulation of insulin receptor signaling pathway; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071390 cellular response to ecdysone; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0075522 IRES-dependent viral translational initiation; GO:0080090 regulation of primary metabolic process; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0110017 cap-independent translational initiation of linear mRNA; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900078 positive regulation of cellular response to insulin stimulus; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903008 organelle disassembly; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0032991 protein-containing complex; GO:0070992 translation initiation complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003743 translation initiation factor activity; GO:0005488 binding; GO:0008135 translation factor activity"," RNA binding; GO:0043021 ribonucleoprotein complex binding; GO:0043022 ribosome binding; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF01253","PF01253 Translation initiation factor SUI1","R","KOG3239","Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1)"]
["O43592","Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2","XPOT",0.974865823,0.33353513,"nochange",45602.7,44155.6,45734.5,44400.8,42319.7,45366.8,1.022558105,0.990109504,1.025513482,0.99560767,0.948942765,1.017268474,"cytoplasm","K14288","XPOT; exportin-T","hsa03013 Nucleocytoplasmic transport","GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006409 tRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0051031 tRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071528 tRNA re-export from nucleus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0097064 ncRNA export from nucleus;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016363 nuclear matrix; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000049 tRNA binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"YUJ","KOG2021","Nuclear mRNA export factor receptor LOS1/Exportin-t (importin beta superfamily)",{"$nulls":3},"R-HSA-6784531 tRNA processing in the nucleus;R-HSA-72306 tRNA processing;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6784531;https://reactome.org/PathwayBrowser/#/R-HSA-72306;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V1;UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["O43598","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1","DNPH1",1.190003616,0.00386933,"up",20678.6,21390,19871.8,25530.6,23947.5,24231.2,0.914647065,0.946113408,0.87896103,1.129258671,1.059235664,1.071784162,"cytoplasm","K22928",null,null,"GO:0001558 regulation of cell growth; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006195 purine nucleotide catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009125 nucleoside monophosphate catabolic process; GO:0009159 deoxyribonucleoside monophosphate catabolic process; GO:0009162 deoxyribonucleoside monophosphate metabolic process; GO:0009166 nucleotide catabolic process; GO:0009888 tissue development; GO:0009987 cellular process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0030154 cell differentiation; GO:0030307 positive regulation of cell growth; GO:0030855 epithelial cell differentiation; GO:0032502 developmental process; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0040008 regulation of growth; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045927 positive regulation of growth; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072523 purine-containing compound catabolic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0016799 hydrolase activity"," hydrolyzing N-glycosyl compounds; GO:0042802 identical protein binding; GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity;","PF05014","PF05014 Nucleoside 2-deoxyribosyltransferase",{"$nulls":6},"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-74259 Purine catabolism;R-HSA-8956319 Nucleotide catabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-74259;https://reactome.org/PathwayBrowser/#/R-HSA-8956319"]
["O43615","Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2","TIMM44",1.016336621,0.120261128,"nochange",73152,73570.3,72631.5,73670.5,75398,73868.8,0.992360009,0.998034552,0.985299049,0.999393838,1.02282863,1.002083922,"mitochondria","K17804",null,null,"GO:0001101 response to acid chemical; GO:0001666 response to hypoxia; GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0007507 heart development; GO:0008104 protein localization; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0014070 response to organic cyclic compound; GO:0014706 striated muscle tissue development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0030150 protein import into mitochondrial matrix; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0035051 cardiocyte differentiation; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0042692 muscle cell differentiation; GO:0042886 amide transport; GO:0043200 response to amino acid; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055007 cardiac muscle cell differentiation; GO:0055085 transmembrane transport; GO:0060537 muscle tissue development; GO:0061061 muscle structure development; GO:0065002 intracellular protein transmembrane transport; GO:0070482 response to oxygen levels; GO:0070585 protein localization to mitochondrion; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:0097066 response to thyroid hormone; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1905242 response to 3","3'","5-triiodo-L-thyronine; GO:1990542 mitochondrial transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005744 TIM23 mitochondrial import inner membrane translocase complex; GO:0005759 mitochondrial matrix; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex;","GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008320 protein transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015450 protein-transporting ATPase activity; GO:0019899 enzyme binding; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022884 macromolecule transmembrane transporter activity; GO:0042887 amide transmembrane transporter activity; GO:0051087 chaperone binding; GO:1904680 peptide transmembrane transporter activity;","PF04280","PF04280 Tim44-like domain","U","KOG2580","Mitochondrial import inner membrane translocase"," subunit TIM44",{"$nulls":3},"R-HSA-1268020 Mitochondrial protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1268020;https://reactome.org/PathwayBrowser/#/R-HSA-9609507"]
["O43617","Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1","TRAPPC3",0.649155831,0.001734501,"down",22937.4,23656.7,22254.7,13655.8,14537.7,16500.1,1.212096979,1.250107449,1.176020588,0.721622936,0.768225791,0.871926258,"mitochondria","K20302",null,null,"GO:0002790 peptide secretion; GO:0006403 RNA localization; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006891 intra-Golgi vesicle-mediated transport; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0009306 protein secretion; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016192 vesicle-mediated transport; GO:0018996 molting cycle"," collagen and cuticulin-based cuticle; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033227 dsRNA transport; GO:0035264 multicellular organism growth; GO:0040002 collagen and cuticulin-based cuticle development; GO:0040007 growth; GO:0042303 molting cycle; GO:0042335 cuticle development; GO:0042338 cuticle development involved in collagen and cuticulin-based cuticle molting cycle; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048589 developmental growth; GO:0048856 anatomical structure development; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030008 TRAPP complex; GO:0031090 organelle membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0099023 vesicle tethering complex;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"U","KOG3330","Transport protein particle (TRAPP) complex subunit",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs;R-HSA-9007101 Rab regulation of trafficking;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8876198;https://reactome.org/PathwayBrowser/#/R-HSA-9007101;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["O43633","Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1","CHMP2A",1.042587061,0.316937036,"nochange",17722.8,17973.5,17134.3,17492.9,19532.6,18055,0.985411139,0.999350391,0.95268976,0.972628395,1.086038415,1.003881899,"cytoplasm","K12191","CHMP2A; charged multivesicular body protein 2A","hsa04217 Necroptosis; hsa04144 Endocytosis","GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0000920 septum digestion after cytokinesis; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006914 autophagy; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006998 nuclear envelope organization; GO:0007032 endosome organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007080 mitotic metaphase plate congression; GO:0007088 regulation of mitotic nuclear division; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008593 regulation of Notch signaling pathway; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010324 membrane invagination; GO:0010458 exit from mitosis; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010824 regulation of centrosome duplication; GO:0010826 negative regulation of centrosome duplication; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0017157 regulation of exocytosis; GO:0019058 viral life cycle; GO:0019068 virion assembly; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030163 protein catabolic process; GO:0031468 nuclear membrane reassembly; GO:0032509 endosome transport via multivesicular body sorting pathway; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0036257 multivesicular body organization; GO:0036258 multivesicular body assembly; GO:0039702 viral budding via host ESCRT complex; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; GO:0043170 macromolecule metabolic process; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0045184 establishment of protein localization; GO:0045746 negative regulation of Notch signaling pathway; GO:0045786 negative regulation of cell cycle; GO:0045921 positive regulation of exocytosis; GO:0046599 regulation of centriole replication; GO:0046600 negative regulation of centriole replication; GO:0046605 regulation of centrosome cycle; GO:0046606 negative regulation of centrosome cycle; GO:0046755 viral budding; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050000 chromosome localization; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051258 protein polymerization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051276 chromosome organization; GO:0051291 protein heterooligomerization; GO:0051301 cell division; GO:0051303 establishment of chromosome localization; GO:0051310 metaphase plate congression; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0060236 regulation of mitotic spindle organization; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061919 process utilizing autophagic mechanism; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071985 multivesicular body sorting pathway; GO:0090169 regulation of spindle assembly; GO:0090224 regulation of spindle organization; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901673 regulation of mitotic spindle assembly; GO:1902115 regulation of organelle assembly; GO:1902116 negative regulation of organelle assembly; GO:1903047 mitotic cell cycle process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903541 regulation of exosomal secretion; GO:1903543 positive regulation of exosomal secretion; GO:1903722 regulation of centriole elongation; GO:1903723 negative regulation of centriole elongation; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:1904896 ESCRT complex disassembly; GO:1904903 ESCRT III complex disassembly;","GO:0000815 ESCRT III complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030117 membrane coat; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036452 ESCRT complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048475 coated membrane; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0019904 protein domain specific binding; GO:0031210 phosphatidylcholine binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0050997 quaternary ammonium group binding; GO:0070405 ammonium ion binding;",null,null,"U","KOG3230","Vacuolar assembly/sorting protein DID4",{"$nulls":3},"R-HSA-162587 HIV Life Cycle;R-HSA-162588 Budding and maturation of HIV virion;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1632852 Macroautophagy;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2995410 Nuclear Envelope (NE) Reassembly;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-5218859 Regulated Necrosis;R-HSA-5357801 Programmed Cell Death;R-HSA-5620971 Pyroptosis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT);R-HSA-9609646 HCMV Infection;R-HSA-9610379 HCMV Late Events;R-HSA-9612973 Autophagy;R-HSA-9615710 Late endosomal microautophagy;R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III;R-HSA-9678108 SARS-CoV-1 Infection;R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex;R-HSA-9772572 Early SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162588;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-2995410;https://reactome.org/PathwayBrowser/#/R-HSA-432720;https://reactome.org/PathwayBrowser/#/R-HSA-5218859;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-5620971;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-917729;https://reactome.org/PathwayBrowser/#/R-HSA-9609646;https://reactome.org/PathwayBrowser/#/R-HSA-9610379;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9615710;https://reactome.org/PathwayBrowser/#/R-HSA-9668328;https://reactome.org/PathwayBrowser/#/R-HSA-9678108;https://reactome.org/PathwayBrowser/#/R-HSA-9679504;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694676;https://reactome.org/PathwayBrowser/#/R-HSA-9772572"]
["O43639","Cytoplasmic protein NCK2 OS=Homo sapiens OX=9606 GN=NCK2 PE=1 SV=2","NCK2",1.193613785,0.0507528,"nochange",2891.34,2363.49,2607.73,2954.72,3253.65,3176.49,1.005833916,0.822206452,0.907172203,1.027882431,1.131873637,1.105031361,"cytoplasm","nucleus","K19862","NCK2; NCK adaptor protein 2","hsa05130 Pathogenic Escherichia coli infection; hsa04360 Axon guidance; hsa04012 ErbB signaling pathway; hsa04660 T cell receptor signaling pathway","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000768 syncytium formation by plasma membrane fusion; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001771 immunological synapse formation; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006949 syncytium formation; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007172 signal complex assembly; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007176 regulation of epidermal growth factor-activated receptor activity; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007520 myoblast fusion; GO:0008037 cell recognition; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009988 cell-cell recognition; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014902 myotube differentiation; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030032 lamellipodium assembly; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030182 neuron differentiation; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032056 positive regulation of translation in response to stress; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032944 regulation of mononuclear cell proliferation; GO:0032946 positive regulation of mononuclear cell proliferation; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033135 regulation of peptidyl-serine phosphorylation; GO:0033137 negative regulation of peptidyl-serine phosphorylation; GO:0033554 cellular response to stress; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034976 response to endoplasmic reticulum stress; GO:0036490 regulation of translation in response to endoplasmic reticulum stress; GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress; GO:0038127 ERBB signaling pathway; GO:0040011 locomotion; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042102 positive regulation of T cell proliferation; GO:0042110 T cell activation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0042692 muscle cell differentiation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043254 regulation of protein-containing complex assembly; GO:0043549 regulation of kinase activity; GO:0043555 regulation of translation in response to stress; GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045321 leukocyte activation; GO:0045727 positive regulation of translation; GO:0045785 positive regulation of cell adhesion; GO:0045859 regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0046649 lymphocyte activation; GO:0048010 vascular endothelial growth factor receptor signaling pathway; GO:0048013 ephrin receptor signaling pathway; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050670 regulation of lymphocyte proliferation; GO:0050671 positive regulation of lymphocyte proliferation; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060996 dendritic spine development; GO:0061061 muscle structure development; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061564 axon development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070663 regulation of leukocyte proliferation; GO:0070665 positive regulation of leukocyte proliferation; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0097581 lamellipodium organization; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1900101 regulation of endoplasmic reticulum unfolded protein response; GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response; GO:1901184 regulation of ERBB signaling pathway; GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903573 negative regulation of response to endoplasmic reticulum stress; GO:1903897 regulation of PERK-mediated unfolded protein response; GO:1903898 negative regulation of PERK-mediated unfolded protein response; GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; GO:1905897 regulation of response to endoplasmic reticulum stress; GO:1905898 positive regulation of response to endoplasmic reticulum stress; GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045202 synapse; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization;","GO:0001784 phosphotyrosine residue binding; GO:0005102 signaling receptor binding; GO:0005158 insulin receptor binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008093 cytoskeletal anchor activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030159 signaling receptor complex adaptor activity; GO:0030674 protein-macromolecule adaptor activity; GO:0035591 signaling adaptor activity; GO:0044877 protein-containing complex binding; GO:0045309 protein phosphorylated amino acid binding; GO:0050839 cell adhesion molecule binding; GO:0051219 phosphoprotein binding; GO:0060090 molecular adaptor activity; GO:0097110 scaffold protein binding;","PF00018; PF14604; PF00017","PF00018 SH3 domain; PF14604 Variant SH3 domain; PF00017 SH2 domain","T","KOG4226","Adaptor protein NCK/Dock"," contains SH2 and SH3 domains","WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP437 EGFEGFR SIGNALING PATHWAY;WP673 ERBB SIGNALING PATHWAY;WP4823 GENES CONTROLLING NEPHROGENESIS;WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION","http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP673_r118930;http://www.wikipathways.org/instance/WP4823_r119116;http://www.wikipathways.org/instance/WP2272_r118427",null,"R-HSA-1266738 Developmental Biology;R-HSA-1500931 Cell-Cell communication;R-HSA-162582 Signal Transduction;R-HSA-186763 Downstream signal transduction;R-HSA-186797 Signaling by PDGF;R-HSA-194138 Signaling by VEGF;R-HSA-194315 Signaling by Rho GTPases;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-373753 Nephrin family interactions;R-HSA-376176 Signaling by ROBO receptors;R-HSA-3928664 Ephrin signaling;R-HSA-422475 Axon guidance;R-HSA-428540 Activation of RAC1;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-8985801 Regulation of cortical dendrite branching;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013424 RHOV GTPase cycle;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1500931;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-186763;https://reactome.org/PathwayBrowser/#/R-HSA-186797;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-373753;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-3928664;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-428540;https://reactome.org/PathwayBrowser/#/R-HSA-4420097;https://reactome.org/PathwayBrowser/#/R-HSA-8985801;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-9013424;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O43660","Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1","PLRG1",1.025149313,0.676829613,"nochange",12602.5,13417.9,12891.2,14198.2,13590.9,12101.1,0.959559299,1.021644176,0.981541031,1.081056524,1.034816464,0.921382506,"nucleus","K12862","PLRG1; pleiotropic regulator 1","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0002790 peptide secretion; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009306 protein secretion; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010467 gene expression; GO:0010564 regulation of cell cycle process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0045787 positive regulation of cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051726 regulation of cell cycle; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:1900087 positive regulation of G1/S transition of mitotic cell cycle; GO:1901360 organic cyclic compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902808 positive regulation of cell cycle G1/S phase transition; GO:2000045 regulation of G1/S transition of mitotic cell cycle;","GO:0000151 ubiquitin ligase complex; GO:0000974 Prp19 complex; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031090 organelle membrane; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071007 U2-type catalytic step 2 spliceosome; GO:0071011 precatalytic spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:0080008 Cul4-RING E3 ubiquitin ligase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"A","KOG0285","Pleiotropic regulator 1",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O43663","Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2","PRC1",2.192731292,3.40952E-4,"up",11624.7,12010.7,13909.1,25246.1,28120.7,28958.2,0.581867781,0.601188793,0.696212131,1.263679251,1.407565728,1.449486316,"nucleus","K16732",null,null,"GO:0000022 mitotic spindle elongation; GO:0000070 mitotic sister chromatid segregation; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000281 mitotic cytokinesis; GO:0000819 sister chromatid segregation; GO:0000910 cytokinesis; GO:0000916 actomyosin contractile ring contraction; GO:0001578 microtubule bundle formation; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0008284 positive regulation of cell population proliferation; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031032 actomyosin structure organization; GO:0032465 regulation of cytokinesis; GO:0032506 cytokinetic process; GO:0036213 contractile ring contraction; GO:0042127 regulation of cell population proliferation; GO:0044837 actomyosin contractile ring organization; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051231 spindle elongation; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051302 regulation of cell division; GO:0051726 regulation of cell cycle; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0015630 microtubule cytoskeleton; GO:0030496 midbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0051233 spindle midzone; GO:0070938 contractile ring; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0042802 identical protein binding;",null,null,"DZ","KOG4302","Microtubule-associated protein essential for anaphase spindle elongation",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-5625900 RHO GTPases activate CIT;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-5625900;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","G2M CHECKPOINT;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O43665","Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3","RGS10",1.118763173,0.165810734,"nochange",30163,25099.2,24399.7,28882,29553,30687.8,1.072241738,0.892232531,0.867366533,1.026704435,1.050557308,1.090897457,"nucleus","K16449",null,null,"GO:0001975 response to amphetamine; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007213 G protein-coupled acetylcholine receptor signaling pathway; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0009410 response to xenobiotic stimulus; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010646 regulation of cell communication; GO:0014075 response to amine; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0032870 cellular response to hormone stimulus; GO:0042221 response to chemical; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0048583 regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0060359 response to ammonium ion; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0071242 cellular response to ammonium ion; GO:0071310 cellular response to organic substance; GO:0071495 cellular response to endogenous stimulus; GO:0095500 acetylcholine receptor signaling pathway; GO:0097366 response to bronchodilator; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903831 signal transduction involved in cellular response to ammonium ion; GO:1905144 response to acetylcholine; GO:1905145 cellular response to acetylcholine;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0044309 neuron spine; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0001965 G-protein alpha-subunit binding; GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00615","PF00615 Regulator of G protein signaling domain","T","KOG3589","G protein signaling regulators","WP536 CALCIUM REGULATION IN CARDIAC CELLS;WP2853 ENDODERM DIFFERENTIATION;WP2857 MESODERMAL COMMITMENT PATHWAY;WP289 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS","http://www.wikipathways.org/instance/WP536_r116854;http://www.wikipathways.org/instance/WP2853_r116557;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP289_r120734",null,"R-HSA-162582 Signal Transduction;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-418594 G alpha (i) signalling events","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-418594"]
["O43670","BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1","ZNF207",1.027805843,0.48114882,"nochange",83040.2,74661.5,83503,83237.5,81575.8,83098.3,1.01865589,0.9158742,1.024333068,1.021076173,1.000692064,1.019368604,"nucleus",{"$nulls":3},"GO:0000070 mitotic sister chromatid segregation; GO:0000075 cell cycle checkpoint signaling; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001578 microtubule bundle formation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0007088 regulation of mitotic nuclear division; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007094 mitotic spindle assembly checkpoint signaling; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008608 attachment of spindle microtubules to kinetochore; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031109 microtubule polymerization or depolymerization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031577 spindle checkpoint signaling; GO:0031647 regulation of protein stability; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045786 negative regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045841 negative regulation of mitotic metaphase/anaphase transition; GO:0045930 negative regulation of mitotic cell cycle; GO:0046785 microtubule polymerization; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051225 spindle assembly; GO:0051252 regulation of RNA metabolic process; GO:0051258 protein polymerization; GO:0051276 chromosome organization; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070925 organelle assembly; GO:0071173 spindle assembly checkpoint signaling; GO:0071174 mitotic spindle checkpoint signaling; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090307 mitotic spindle assembly; GO:0097435 supramolecular fiber organization; GO:0098813 nuclear chromosome segregation; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140014 mitotic nuclear division; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005856 cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1990047 spindle matrix;","GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005539 glycosaminoglycan binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008201 heparin binding; GO:0008270 zinc ion binding; GO:0015631 tubulin binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097367 carbohydrate derivative binding; GO:0140110 transcription regulator activity; GO:1901681 sulfur compound binding;",null,null,"R","KOG2893","Zn finger protein",null,null,"Transcription factor"]
["O43674","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5"," mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB5 PE=1 SV=1","NDUFB5",0.939341141,0.222420526,"nochange",29305.8,27451.8,27897.8,27721.1,24463.7,27335.5,1.071015991,1.003259313,1.019558924,1.013101208,0.894055576,0.999008989,"mitochondria","K03961","NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0000302 response to reactive oxygen species; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0010259 multicellular organism aging; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045271 respiratory chain complex I; GO:0070013 intracellular organelle lumen; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0050136 NADH dehydrogenase (quinone) activity;",null,null,"C","KOG4632","NADH:ubiquinone oxidoreductase"," NDUFB5/SGDH subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 OS=Homo sapiens OX=9606 GN=NDUFB3 PE=1 SV=3","NDUFB3",1.161846414,0.045772219,"nochange",51456,51449.2,45596.7,58658,60102.6,53775.8,0.96167965,0.961552562,0.85217309,1.096280413,1.12327906,1.005035225,"cytoplasm","K03959","NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045271 respiratory chain complex I; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0050136 NADH dehydrogenase (quinone) activity;",null,null,"C","KOG4631","NADH:ubiquinone oxidoreductase"," NDUFB3/B12 subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3","NDUFA2",0.946739569,0.260493131,"nochange",107171,117988,114474,106785,113102,101657,0.972547442,1.070708751,1.038820165,0.969044598,1.026369641,0.922509404,"mitochondria","K03946","NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045271 respiratory chain complex I; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0050136 NADH dehydrogenase (quinone) activity;","PF05047","PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ","C","KOG3446","NADH:ubiquinone oxidoreductase NDUFA2/B8 subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O43681","ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2","GET3",1.153057324,0.02557856,"nochange",64017.6,56229.5,62613.8,69205.4,71737.8,69905.9,0.975605395,0.856917528,0.954211983,1.054665617,1.09325849,1.065340987,"cytoplasm","K01551",null,null,"GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0008104 protein localization; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0015698 inorganic anion transport; GO:0015700 arsenite transport; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0032024 positive regulation of insulin secretion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034220 ion transmembrane transport; GO:0034613 cellular protein localization; GO:0034620 cellular response to unfolded protein; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036498 IRE1-mediated unfolded protein response; GO:0042221 response to chemical; GO:0044085 cellular component biogenesis; GO:0045048 protein insertion into ER membrane; GO:0045184 establishment of protein localization; GO:0046685 response to arsenic-containing substance; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051179 localization; GO:0051205 protein insertion into membrane; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071722 detoxification of arsenic-containing substance; GO:0071816 tail-anchored membrane protein insertion into ER membrane; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0090087 regulation of peptide transport; GO:0090150 establishment of protein localization to membrane; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:0098656 anion transmembrane transport; GO:0098754 detoxification; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904951 positive regulation of establishment of protein localization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030424 axon; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031984 organelle subcompartment; GO:0036477 somatodendritic compartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0070013 intracellular organelle lumen; GO:0098827 endoplasmic reticulum subcompartment; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008509 anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015105 arsenite transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0022857 transmembrane transporter activity;","PF02374","PF02374 Anion-transporting ATPase","P","KOG2825","Putative arsenite-translocating ATPase",{"$nulls":3},"R-HSA-9609507 Protein localization;R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","https://reactome.org/PathwayBrowser/#/R-HSA-9609507;https://reactome.org/PathwayBrowser/#/R-HSA-9609523"]
["O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1","BUB1",1.161756891,0.425903645,"nochange",1583.78,2411.29,3155.29,2448.99,2917.41,2940.58,0.61476813,0.935978635,1.224773473,0.95061246,1.132436758,1.141430544,"nucleus","K02178","BUB1; checkpoint serine/threonine-protein kinase [EC:2.7.11.1]","hsa04110 Cell cycle; hsa04914 Progesterone-mediated oocyte maturation; hsa04114 Oocyte meiosis","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000212 meiotic spindle organization; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007059 chromosome segregation; GO:0007062 sister chromatid cohesion; GO:0007063 regulation of sister chromatid cohesion; GO:0007065 male meiosis sister chromatid cohesion; GO:0007066 female meiosis sister chromatid cohesion; GO:0007088 regulation of mitotic nuclear division; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007094 mitotic spindle assembly checkpoint signaling; GO:0007096 regulation of exit from mitosis; GO:0007135 meiosis II; GO:0007140 male meiotic nuclear division; GO:0007143 female meiotic nuclear division; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007548 sex differentiation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008406 gonad development; GO:0008608 attachment of spindle microtubules to kinetochore; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031577 spindle checkpoint signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0033365 protein localization to organelle; GO:0034501 protein localization to kinetochore; GO:0034502 protein localization to chromosome; GO:0034508 centromere complex assembly; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045132 meiotic chromosome segregation; GO:0045137 development of primary sexual characteristics; GO:0045144 meiotic sister chromatid segregation; GO:0045786 negative regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045841 negative regulation of mitotic metaphase/anaphase transition; GO:0045930 negative regulation of mitotic cell cycle; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051177 meiotic sister chromatid cohesion; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051252 regulation of RNA metabolic process; GO:0051255 spindle midzone assembly; GO:0051257 meiotic spindle midzone assembly; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051304 chromosome separation; GO:0051307 meiotic chromosome separation; GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation; GO:0051321 meiotic cell cycle; GO:0051382 kinetochore assembly; GO:0051383 kinetochore organization; GO:0051641 cellular localization; GO:0051726 regulation of cell cycle; GO:0051754 meiotic sister chromatid cohesion"," centromeric; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061458 reproductive system development; GO:0061983 meiosis II cell cycle process; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070193 synaptonemal complex organization; GO:0070601 centromeric sister chromatid cohesion; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071173 spindle assembly checkpoint signaling; GO:0071174 mitotic spindle checkpoint signaling; GO:0071459 protein localization to chromosome"," centromeric region; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903394 protein localization to kinetochore involved in kinetochore assembly; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903829 positive regulation of protein localization; GO:1905269 positive regulation of chromatin organization; GO:1905340 regulation of protein localization to kinetochore; GO:1905342 positive regulation of protein localization to kinetochore; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000940 outer kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0140096 catalytic activity"," acting on a protein;","PF08311; PF00069","PF08311 Mad3/BUB1 homology region 1; PF00069 Protein kinase domain","D","KOG1166","Mitotic checkpoint serine/threonine protein kinase","WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE;WP179 CELL CYCLE;WP4240 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASEANAPHASE TRANSITION","http://www.wikipathways.org/instance/WP3878_r117656;http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP4240_r106495",null,"R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","G2M CHECKPOINT;MITOTIC SPINDLE;MTORC1 SIGNALING;SPERMATOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_SPERMATOGENESIS"]
["O43684","Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1","BUB3",1.041169729,0.093537566,"nochange",140248,143175,148472,147575,150470,151631,0.954532307,0.974453561,1.01050511,1.004400099,1.024103561,1.032005363,"nucleus","K02180","BUB3; cell cycle arrest protein BUB3","hsa04110 Cell cycle; hsa05166 Human T-cell leukemia virus 1 infection","GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000075 cell cycle checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007088 regulation of mitotic nuclear division; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007094 mitotic spindle assembly checkpoint signaling; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008608 attachment of spindle microtubules to kinetochore; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030163 protein catabolic process; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0031577 spindle checkpoint signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0033313 meiotic cell cycle checkpoint signaling; GO:0033316 meiotic spindle assembly checkpoint signaling; GO:0040020 regulation of meiotic nuclear division; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044779 meiotic spindle checkpoint signaling; GO:0045786 negative regulation of cell cycle; GO:0045835 negative regulation of meiotic nuclear division; GO:0045839 negative regulation of mitotic nuclear division; GO:0045841 negative regulation of mitotic metaphase/anaphase transition; GO:0045930 negative regulation of mitotic cell cycle; GO:0048285 organelle fission; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051445 regulation of meiotic cell cycle; GO:0051447 negative regulation of meiotic cell cycle; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0065007 biological regulation; GO:0071173 spindle assembly checkpoint signaling; GO:0071174 mitotic spindle checkpoint signaling; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1901993 regulation of meiotic cell cycle phase transition; GO:1901994 negative regulation of meiotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle; GO:1902102 regulation of metaphase/anaphase transition of meiotic cell cycle; GO:1902103 negative regulation of metaphase/anaphase transition of meiotic cell cycle; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1905132 regulation of meiotic chromosome separation; GO:1905133 negative regulation of meiotic chromosome separation; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:2000241 regulation of reproductive process; GO:2000242 negative regulation of reproductive process; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001251 negative regulation of chromosome organization;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033597 mitotic checkpoint complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1990298 bub1-bub3 complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0032182 ubiquitin-like protein binding; GO:0043130 ubiquitin binding;",null,null,"D","KOG1036","Mitotic spindle checkpoint protein BUB3"," WD repeat superfamily","WP179 CELL CYCLE;WP4240 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASEANAPHASE TRANSITION","http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP4240_r106495",null,"R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-141405;https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141430;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-174143;https://reactome.org/PathwayBrowser/#/R-HSA-174184;https://reactome.org/PathwayBrowser/#/R-HSA-176408;https://reactome.org/PathwayBrowser/#/R-HSA-176409;https://reactome.org/PathwayBrowser/#/R-HSA-176814;https://reactome.org/PathwayBrowser/#/R-HSA-179409;https://reactome.org/PathwayBrowser/#/R-HSA-179419;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-453276;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","G2M CHECKPOINT;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O43707","Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2","ACTN4",1.011153492,0.392354246,"nochange",265678,272702,270694,268048,274876,275174,0.9796555,1.005555651,0.998151394,0.988394589,1.013572013,1.014670852,"cytoplasm","K05699","ACTN1_4; actinin alpha 1/4","hsa04510 Focal adhesion; hsa05146 Amoebiasis; hsa05203 Viral carcinogenesis; hsa04530 Tight junction; hsa05131 Shigellosis; hsa04810 Regulation of actin cytoskeleton; hsa05322 Systemic lupus erythematosus; hsa04520 Adherens junction; hsa04670 Leukocyte transendothelial migration","GO:0001666 response to hypoxia; GO:0002028 regulation of sodium ion transport; GO:0002576 platelet degranulation; GO:0006810 transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007043 cell-cell junction assembly; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0008104 protein localization; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010155 regulation of proton transport; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010765 positive regulation of sodium ion transport; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0010941 regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030048 actin filament-based movement; GO:0030050 vesicle transport along actin filament; GO:0030100 regulation of endocytosis; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030522 intracellular receptor signaling pathway; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032415 regulation of sodium:proton antiporter activity; GO:0032417 positive regulation of sodium:proton antiporter activity; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0035357 peroxisome proliferator activated receptor signaling pathway; GO:0036293 response to decreased oxygen levels; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042981 regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043297 apical junction assembly; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045055 regulated exocytosis; GO:0045216 cell-cell junction organization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045807 positive regulation of endocytosis; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048384 retinoic acid receptor signaling pathway; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048548 regulation of pinocytosis; GO:0048549 positive regulation of pinocytosis; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051017 actin filament bundle assembly; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060627 regulation of vesicle-mediated transport; GO:0061572 actin filament bundle organization; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070482 response to oxygen levels; GO:0070830 bicellular tight junction assembly; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0097435 supramolecular fiber organization; GO:0099515 actin filament-based transport; GO:0099518 vesicle cytoskeletal trafficking; GO:1900024 regulation of substrate adhesion-dependent cell spreading; GO:1900025 negative regulation of substrate adhesion-dependent cell spreading; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901224 positive regulation of NIK/NF-kappaB signaling; GO:1902305 regulation of sodium ion transmembrane transport; GO:1902307 positive regulation of sodium ion transmembrane transport; GO:1902396 protein localization to bicellular tight junction; GO:1902414 protein localization to cell junction; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2000651 positive regulation of sodium ion transmembrane transporter activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0001725 stress fiber; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005911 cell-cell junction; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016604 nuclear body; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0030054 cell junction; GO:0030141 secretory granule; GO:0030863 cortical cytoskeleton; GO:0031091 platelet alpha granule; GO:0031093 platelet alpha granule lumen; GO:0031143 pseudopodium; GO:0031410 cytoplasmic vesicle; GO:0031674 I band; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032432 actin filament bundle; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0042641 actomyosin; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0048471 perinuclear region of cytoplasm; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097517 contractile actin filament bundle; GO:0097708 intracellular vesicle; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:1990904 ribonucleoprotein complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001882 nucleoside binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003779 actin binding; GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008134 transcription factor binding; GO:0030374 nuclear receptor coactivator activity; GO:0031490 chromatin DNA binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0042974 retinoic acid receptor binding; GO:0043565 sequence-specific DNA binding; GO:0044325 transmembrane transporter binding; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0047485 protein N-terminus binding; GO:0050839 cell adhesion molecule binding; GO:0051015 actin filament binding; GO:0051427 hormone receptor binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00307; PF00435; PF08726","PF00307 Calponin homology (CH) domain; PF00435 Spectrin repeat; PF08726 Ca2+ insensitive EF hand","Z","KOG0035","Ca2+-binding actin-bundling protein (actinin)"," alpha chain (EF-Hand protein superfamily)","WP2118 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY;WP4217 EBOLA VIRUS INFECTION IN HOST;WP306 FOCAL ADHESION;WP4758 NEPHROTIC SYNDROME;WP2572 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS;WP383 STRIATED MUSCLE CONTRACTION PATHWAY","http://www.wikipathways.org/instance/WP2118_r119252;http://www.wikipathways.org/instance/WP4217_r120623;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP4758_r108284;http://www.wikipathways.org/instance/WP2572_r119251;http://www.wikipathways.org/instance/WP383_r118423",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-1500931 Cell-Cell communication;R-HSA-373753 Nephrin family interactions;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-1500931;https://reactome.org/PathwayBrowser/#/R-HSA-373753;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005","APICAL JUNCTION;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O43708","Maleylacetoacetate isomerase OS=Homo sapiens OX=9606 GN=GSTZ1 PE=1 SV=3","GSTZ1",1.119440261,2.186E-4,"up",16096.2,16471.4,16240.9,18400.2,18035.6,18202.4,0.933593822,0.955355753,0.94198655,1.067227857,1.046080735,1.055755283,"mitochondria","K01800","maiA; maleylacetoacetate isomerase [EC:5.2.1.2]","hsa00350 Tyrosine metabolism; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006558 L-phenylalanine metabolic process; GO:0006559 L-phenylalanine catabolic process; GO:0006570 tyrosine metabolic process; GO:0006572 tyrosine catabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006749 glutathione metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009063 cellular amino acid catabolic process; GO:0009072 aromatic amino acid family metabolic process; GO:0009074 aromatic amino acid family catabolic process; GO:0009636 response to toxic substance; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate; GO:0010565 regulation of cellular ketone metabolic process; GO:0016054 organic acid catabolic process; GO:0019216 regulation of lipid metabolic process; GO:0019217 regulation of fatty acid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019752 carboxylic acid metabolic process; GO:0030808 regulation of nucleotide biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0034248 regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042762 regulation of sulfur metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050812 regulation of acyl-CoA biosynthetic process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051716 cellular response to stimulus; GO:0062012 regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0097237 cellular response to toxic substance; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901606 alpha-amino acid catabolic process; GO:1901685 glutathione derivative metabolic process; GO:1901687 glutathione derivative biosynthetic process; GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process; GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process; GO:1990748 cellular detoxification;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004364 glutathione transferase activity; GO:0004601 peroxidase activity; GO:0004602 glutathione peroxidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016034 maleylacetoacetate isomerase activity; GO:0016209 antioxidant activity; GO:0016491 oxidoreductase activity; GO:0016684 oxidoreductase activity"," acting on peroxide as acceptor; GO:0016740 transferase activity; GO:0016765 transferase activity"," transferring alkyl or aryl (other than methyl) groups; GO:0016787 hydrolase activity; GO:0016824 hydrolase activity"," acting on acid halide bonds; GO:0016853 isomerase activity; GO:0016859 cis-trans isomerase activity; GO:0019120 hydrolase activity"," acting on acid halide bonds"," in C-halide compounds; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity;","PF13417; PF14497","PF13417 Glutathione S-transferase"," N-terminal domain; PF14497 Glutathione S-transferase"," C-terminal domain","O","KOG0868","Glutathione S-transferase","WP702 METAPATHWAY BIOTRANSFORMATION PHASE I AND II","http://www.wikipathways.org/instance/WP702_r106643",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex;R-HSA-211859 Biological oxidations;R-HSA-70268 Pyruvate metabolism;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle;R-HSA-8963684 Tyrosine catabolism;R-HSA-8963691 Phenylalanine and tyrosine metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-204174;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-70268;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-71406;https://reactome.org/PathwayBrowser/#/R-HSA-8963684;https://reactome.org/PathwayBrowser/#/R-HSA-8963691","FATTY ACID METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM"]
["O43715","TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1","TRIAP1",0.975974974,0.977584751,"nochange",2174.2,2034.07,3581.94,2323.5,2453.15,2826.4,0.847461811,0.792841802,1.396172091,0.905656112,0.956191216,1.101676968,"extracellular","K17968",null,null,"GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0001655 urogenital system development; GO:0001822 kidney development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006977 DNA damage response"," signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010466 negative regulation of peptidase activity; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010876 lipid localization; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010951 negative regulation of endopeptidase activity; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015914 phospholipid transport; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030162 regulation of proteolysis; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032368 regulation of lipid transport; GO:0032370 positive regulation of lipid transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0034644 cellular response to UV; GO:0035556 intracellular signal transduction; GO:0042770 signal transduction in response to DNA damage; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0044070 regulation of anion transport; GO:0044092 negative regulation of molecular function; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045861 negative regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048793 pronephros development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071702 organic substance transport; GO:0071840 cellular component organization or biogenesis; GO:0072001 renal system development; GO:0072331 signal transduction by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090068 positive regulation of cell cycle process; GO:0090199 regulation of release of cytochrome c from mitochondria; GO:0090201 negative regulation of release of cytochrome c from mitochondria; GO:0097035 regulation of membrane lipid distribution; GO:0104004 cellular response to environmental stimulus; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901797 negative regulation of signal transduction by p53 class mediator; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903793 positive regulation of anion transport; GO:1905952 regulation of lipid localization; GO:1905954 positive regulation of lipid localization; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2001020 regulation of response to DNA damage stimulus; GO:2001021 negative regulation of response to DNA damage stimulus; GO:2001138 regulation of phospholipid transport; GO:2001140 positive regulation of phospholipid transport; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005758 mitochondrial intermembrane space; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0002039 p53 binding; GO:0005488 binding; GO:0005515 protein binding;",null,null,"S","KOG3481","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes;R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5633008;https://reactome.org/PathwayBrowser/#/R-HSA-6803204;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160","P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O43716","Glutamyl-tRNA(Gln) amidotransferase subunit C"," mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1","GATC",1.024843986,0.792360641,"nochange",11943.3,13019.3,14793.5,14842.1,12034.6,13867.1,0.890184957,0.970383814,1.102622488,1.106244852,0.896989934,1.033573955,"mitochondria","K02435","gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]","hsa00970 Aminoacyl-tRNA biosynthesis; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032543 mitochondrial translation; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0140053 mitochondrial gene expression; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0016874 ligase activity; GO:0016879 ligase activity"," forming carbon-nitrogen bonds; GO:0016884 carbon-nitrogen ligase activity"," with glutamine as amido-N-donor; GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;",null,null,"L","KOG4247","Mitochondrial DNA polymerase accessory subunit"]
["O43719","HIV Tat-specific factor 1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1","HTATSF1",1.203904768,0.004806591,"up",43727.5,42277.5,42791.4,51277.5,49114.5,54666.6,0.924292332,0.893642881,0.904505469,1.083880855,1.038160328,1.155518134,"nucleus","K13093",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016032 viral process; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019058 viral life cycle; GO:0019079 viral genome replication; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032784 regulation of DNA-templated transcription"," elongation; GO:0033120 positive regulation of RNA splicing; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045595 regulation of cell differentiation; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051960 regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005686 U2 snRNP; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0043021 ribonucleoprotein complex binding; GO:0044877 protein-containing complex binding; GO:0070990 snRNP binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990447 U2 snRNP binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","K","KOG1548","Transcription elongation factor TAT-SF1"]
["O43747","AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5","AP1G1",1.190567042,8.19354E-4,"up",67192.4,68578.5,71002,83053.8,80342.8,82780.4,0.890064,0.908424972,0.94052786,1.100172006,1.064260749,1.096550413,"mitochondria","K12391","AP1G1; AP-1 complex subunit gamma-1","hsa04142 Lysosome; hsa05170 Human immunodeficiency virus 1 infection","GO:0000226 microtubule cytoskeleton organization; GO:0001654 eye development; GO:0001910 regulation of leukocyte mediated cytotoxicity; GO:0001912 positive regulation of leukocyte mediated cytotoxicity; GO:0002376 immune system process; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002703 regulation of leukocyte mediated immunity; GO:0002705 positive regulation of leukocyte mediated immunity; GO:0002706 regulation of lymphocyte mediated immunity; GO:0002708 positive regulation of lymphocyte mediated immunity; GO:0002715 regulation of natural killer cell mediated immunity; GO:0002717 positive regulation of natural killer cell mediated immunity; GO:0002790 peptide secretion; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006896 Golgi to vacuole transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0009306 protein secretion; GO:0009605 response to external stimulus; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016482 cytosolic transport; GO:0017157 regulation of exocytosis; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0021700 developmental maturation; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031341 regulation of cell killing; GO:0031343 positive regulation of cell killing; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0032438 melanosome organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032814 regulation of natural killer cell activation; GO:0032816 positive regulation of natural killer cell activation; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033059 cellular pigmentation; GO:0033363 secretory granule organization; GO:0034613 cellular protein localization; GO:0035459 vesicle cargo loading; GO:0035646 endosome to melanosome transport; GO:0035652 clathrin-coated vesicle cargo loading; GO:0042269 regulation of natural killer cell mediated cytotoxicity; GO:0042886 amide transport; GO:0043300 regulation of leukocyte degranulation; GO:0043302 positive regulation of leukocyte degranulation; GO:0043321 regulation of natural killer cell degranulation; GO:0043323 positive regulation of natural killer cell degranulation; GO:0043473 pigmentation; GO:0043476 pigment accumulation; GO:0043482 cellular pigment accumulation; GO:0043485 endosome to pigment granule transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045176 apical protein localization; GO:0045184 establishment of protein localization; GO:0045921 positive regulation of exocytosis; GO:0045954 positive regulation of natural killer cell mediated cytotoxicity; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048066 developmental pigmentation; GO:0048193 Golgi vesicle transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048731 system development; GO:0048749 compound eye development; GO:0048753 pigment granule organization; GO:0048757 pigment granule maturation; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050690 regulation of defense response to virus by virus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050896 response to stimulus; GO:0050931 pigment cell differentiation; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060627 regulation of vesicle-mediated transport; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080134 regulation of response to stress; GO:0090160 Golgi to lysosome transport; GO:1903305 regulation of regulated secretory pathway; GO:1903307 positive regulation of regulated secretory pathway; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell;","GO:0000139 Golgi membrane; GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005768 endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0012510 trans-Golgi network transport vesicle membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030118 clathrin coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0030120 vesicle coat; GO:0030121 AP-1 adaptor complex; GO:0030125 clathrin vesicle coat; GO:0030130 clathrin coat of trans-Golgi network vesicle; GO:0030131 clathrin adaptor complex; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030140 trans-Golgi network transport vesicle; GO:0030141 secretory granule; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030665 clathrin-coated vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0048475 coated membrane; GO:0055037 recycling endosome; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005518 collagen binding; GO:0008022 protein C-terminus binding; GO:0008092 cytoskeletal protein binding; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0030276 clathrin binding; GO:0030742 GTP-dependent protein binding; GO:0031267 small GTPase binding; GO:0044877 protein-containing complex binding; GO:0051020 GTPase binding;","PF02883","PF02883 Adaptin C-terminal domain","U","KOG1062","Vesicle coat complex AP-1"," gamma subunit","WP5039 SARSCOV2 INNATE IMMUNITY EVASION AND CELLSPECIFIC IMMUNE RESPONSE","http://www.wikipathways.org/instance/WP5039_r120358",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1643685 Disease;R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters;R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression;R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis;R-HSA-168256 Immune System;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-2132295 MHC class II antigen presentation;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-162909;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-164938;https://reactome.org/PathwayBrowser/#/R-HSA-164940;https://reactome.org/PathwayBrowser/#/R-HSA-164952;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-2132295;https://reactome.org/PathwayBrowser/#/R-HSA-432720;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205","PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O43752","Syntaxin-6 OS=Homo sapiens OX=9606 GN=STX6 PE=1 SV=1","STX6",1.216989469,0.010148603,"nochange",8830.57,9958.54,9976.71,12025.6,11475.6,11506.5,0.830805952,0.936928681,0.938638168,1.131403755,1.07965814,1.082565303,"cytoplasm","K08498","STX6; syntaxin 6","hsa04130 SNARE interactions in vesicular transport","GO:0001505 regulation of neurotransmitter levels; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006904 vesicle docking involved in exocytosis; GO:0006906 vesicle fusion; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007032 endosome organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016081 synaptic vesicle docking; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0017156 calcium-ion regulated exocytosis; GO:0022406 membrane docking; GO:0023052 signaling; GO:0023061 signal release; GO:0032456 endocytic recycling; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042886 amide transport; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048278 vesicle docking; GO:0048284 organelle fusion; GO:0048489 synaptic vesicle transport; GO:0050789 regulation of biological process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0060341 regulation of cellular localization; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090161 Golgi ribbon formation; GO:0090174 organelle membrane fusion; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering;","GO:0000138 Golgi trans cisterna; GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0030285 integral component of synaptic vesicle membrane; GO:0030424 axon; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030672 synaptic vesicle membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0045335 phagocytic vesicle; GO:0048471 perinuclear region of cytoplasm; GO:0055037 recycling endosome; GO:0070013 intracellular organelle lumen; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098563 intrinsic component of synaptic vesicle membrane; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098796 membrane protein complex; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0000149 SNARE binding; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019905 syntaxin binding;","PF09177","PF09177 Syntaxin 6"," N-terminal","U","KOG3202","SNARE protein TLG1/Syntaxin 6",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811438 Intra-Golgi traffic;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811438;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442"]
["O43759","Synaptogyrin-1 OS=Homo sapiens OX=9606 GN=SYNGR1 PE=1 SV=2","SYNGR1",1.137131422,0.316670102,"nochange",7305.13,9500.46,8175.92,7994.46,10364.4,10048.4,0.820973774,1.067691951,0.918835927,0.898442875,1.16478428,1.129271193,"plasma membrane",{"$nulls":3},"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006605 protein targeting; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0010646 regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0023051 regulation of signaling; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034097 response to cytokine; GO:0034613 cellular protein localization; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048167 regulation of synaptic plasticity; GO:0048168 regulation of neuronal synaptic plasticity; GO:0048169 regulation of long-term neuronal synaptic plasticity; GO:0048172 regulation of short-term neuronal synaptic plasticity; GO:0048499 synaptic vesicle membrane organization; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0099177 regulation of trans-synaptic signaling; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005886 plasma membrane; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030141 secretory granule; GO:0030424 axon; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0030672 synaptic vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031594 neuromuscular junction; GO:0031982 vesicle; GO:0035577 azurophil granule membrane; GO:0042582 azurophil granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098793 presynapse; GO:0098852 lytic vacuole membrane; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;",null,"PF01284","PF01284 Membrane-associating domain","TU","KOG4016","Synaptic vesicle protein Synaptogyrin involved in regulation of Ca2+-dependent exocytosis",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695","ESTROGEN RESPONSE EARLY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY"]
["O43760","Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1","SYNGR2",1.029796883,0.381303265,"nochange",70565.1,65040.9,68891.9,68729.8,72731.3,69130.2,1.019999075,0.940148286,0.99581343,0.993470319,1.051310899,0.999257991,"plasma membrane",{"$nulls":3},"GO:0006605 protein targeting; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048499 synaptic vesicle membrane organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061024 membrane organization; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005811 lipid droplet; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030672 synaptic vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031594 neuromuscular junction; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098793 presynapse; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle;",null,"PF01284","PF01284 Membrane-associating domain","TU","KOG4016","Synaptic vesicle protein Synaptogyrin involved in regulation of Ca2+-dependent exocytosis",{"$nulls":5},"IL2 STAT5 SIGNALING;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1","SGTA",1.504254568,1.36224E-4,"up",53475.6,54783.6,52285.9,76530.5,82447.2,82523,0.798052361,0.817572525,0.780297668,1.142116147,1.230415042,1.231546257,"cytoplasm","nucleus","K16365",null,null,"GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010256 endomembrane system organization; GO:0010498 proteasomal protein catabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032459 regulation of protein oligomerization; GO:0032460 negative regulation of protein oligomerization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034976 response to endoplasmic reticulum stress; GO:0036503 ERAD pathway; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045048 protein insertion into ER membrane; GO:0045184 establishment of protein localization; GO:0045732 positive regulation of protein catabolic process; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051205 protein insertion into membrane; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071816 tail-anchored membrane protein insertion into ER membrane; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090150 establishment of protein localization to membrane; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process; GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process; GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process; GO:1903332 regulation of protein folding; GO:1903334 positive regulation of protein folding; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903573 negative regulation of response to endoplasmic reticulum stress; GO:1903644 regulation of chaperone-mediated protein folding; GO:1903646 positive regulation of chaperone-mediated protein folding; GO:1904292 regulation of ERAD pathway; GO:1904293 negative regulation of ERAD pathway; GO:1904294 positive regulation of ERAD pathway; GO:1905897 regulation of response to endoplasmic reticulum stress; GO:1905898 positive regulation of response to endoplasmic reticulum stress; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016020 membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043621 protein self-association; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:1904288 BAT3 complex binding;","PF16546","PF16546 Homodimerisation domain of SGTA","R","KOG0553","TPR repeat-containing protein",{"$nulls":3},"R-HSA-9609507 Protein localization;R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","https://reactome.org/PathwayBrowser/#/R-HSA-9609507;https://reactome.org/PathwayBrowser/#/R-HSA-9609523"]
["O43766","Lipoyl synthase"," mitochondrial OS=Homo sapiens OX=9606 GN=LIAS PE=1 SV=3","LIAS",0.308031985,1.19107E-3,"down",7895.01,8602.31,7423.54,1880.14,2449.59,3038.66,1.513940411,1.649571658,1.423531724,0.360534049,0.469731297,0.58269086,"cytoplasm","nucleus","K03644","lipA; lipoyl synthase [EC:2.8.1.8]","hsa01240 Biosynthesis of cofactors; hsa00785 Lipoic acid metabolism; hsa01100 Metabolic pathways","GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0002009 morphogenesis of an epithelium; GO:0002237 response to molecule of bacterial origin; GO:0006082 organic acid metabolic process; GO:0006464 cellular protein modification process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006979 response to oxidative stress; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009106 lipoate metabolic process; GO:0009107 lipoate biosynthetic process; GO:0009249 protein lipoylation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0014020 primary neural tube formation; GO:0016053 organic acid biosynthetic process; GO:0016331 morphogenesis of embryonic epithelium; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0021915 neural tube development; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0051604 protein maturation; GO:0051707 response to other organism; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0071704 organic substance metabolic process; GO:0072175 epithelial tube formation; GO:0072330 monocarboxylic acid biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0016740 transferase activity; GO:0016782 transferase activity"," transferring sulphur-containing groups; GO:0016783 sulfurtransferase activity; GO:0016992 lipoate synthase activity;","PF04055","PF04055 Radical SAM superfamily","H","KOG2672","Lipoate synthase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-389661 Glyoxylate metabolism and glycine degradation;R-HSA-71291 Metabolism of amino acids and derivatives","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-389661;https://reactome.org/PathwayBrowser/#/R-HSA-71291"]
["O43768","Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1","ENSA",1.21703993,0.028687897,"nochange",5959.44,5596.15,5437.32,7240.55,7237.29,6203.21,0.949107553,0.891249553,0.865954097,1.153138667,1.152619475,0.987930656,"cytoplasm",{"$nulls":3},"GO:0000003 reproduction; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0002791 regulation of peptide secretion; GO:0003006 developmental process involved in reproduction; GO:0007049 cell cycle; GO:0007088 regulation of mitotic nuclear division; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007584 response to nutrient; GO:0009605 response to external stimulus; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0030104 water homeostasis; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032515 negative regulation of phosphoprotein phosphatase activity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0034284 response to monosaccharide; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035308 negative regulation of protein dephosphorylation; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0043086 negative regulation of catalytic activity; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0044092 negative regulation of molecular function; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044839 cell cycle G2/M phase transition; GO:0045936 negative regulation of phosphate metabolic process; GO:0046883 regulation of hormone secretion; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050708 regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051223 regulation of protein transport; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051445 regulation of meiotic cell cycle; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:1901700 response to oxygen-containing compound; GO:1903047 mitotic cell cycle process; GO:1903530 regulation of secretion by cell; GO:2000241 regulation of reproductive process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0004857 enzyme inhibitor activity; GO:0004864 protein phosphatase inhibitor activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008200 ion channel inhibitor activity; GO:0015459 potassium channel regulator activity; GO:0016247 channel regulator activity; GO:0016248 channel inhibitor activity; GO:0019208 phosphatase regulator activity; GO:0019212 phosphatase inhibitor activity; GO:0019870 potassium channel inhibitor activity; GO:0019888 protein phosphatase regulator activity; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0030234 enzyme regulator activity; GO:0051721 protein phosphatase 2A binding; GO:0098772 molecular function regulator; GO:0099106 ion channel regulator activity;",null,null,"TU","KOG4076","Regulator of ATP-sensitive K+ channels Alpha-endosulfine/ARPP-19 and related cAMP-regulated phosphoproteins",{"$nulls":3},"R-HSA-1640170 Cell Cycle;R-HSA-2465910 MASTL Facilitates Mitotic Progression;R-HSA-68875 Mitotic Prophase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-2465910;https://reactome.org/PathwayBrowser/#/R-HSA-68875;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278"]
["O43772","Mitochondrial carnitine/acylcarnitine carrier protein OS=Homo sapiens OX=9606 GN=SLC25A20 PE=1 SV=1","SLC25A20",1.045736433,0.418109231,"nochange",18584.8,18775.2,21286.9,19381.8,20970.2,20977.2,0.929425111,0.938947007,1.064557024,0.969283049,1.04871887,1.04906894,"plasma membrane","K15109","SLC25A20_29; solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter)"," member 20/29","hsa04714 Thermogenesis","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0002064 epithelial cell development; GO:0003382 epithelial cell morphogenesis; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006820 anion transport; GO:0006839 mitochondrial transport; GO:0006844 acyl carnitine transport; GO:0006853 carnitine shuttle; GO:0006869 lipid transport; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0007275 multicellular organism development; GO:0007424 open tracheal system development; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0010960 magnesium ion homeostasis; GO:0010961 cellular magnesium ion homeostasis; GO:0015693 magnesium ion transport; GO:0015695 organic cation transport; GO:0015697 quaternary ammonium group transport; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015838 amino-acid betaine transport; GO:0015849 organic acid transport; GO:0015879 carnitine transport; GO:0015908 fatty acid transport; GO:0015909 long-chain fatty acid transport; GO:0016043 cellular component organization; GO:0019725 cellular homeostasis; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030154 cell differentiation; GO:0030855 epithelial cell differentiation; GO:0032365 intracellular lipid transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0034220 ion transmembrane transport; GO:0035002 liquid clearance"," open tracheal system; GO:0042044 fluid transport; GO:0042045 epithelial fluid transport; GO:0042592 homeostatic process; GO:0045016 mitochondrial magnesium ion transmembrane transport; GO:0046907 intracellular transport; GO:0046942 carboxylic acid transport; GO:0048468 cell development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055065 metal ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070633 transepithelial transport; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072337 modified amino acid transport; GO:0072488 ammonium transmembrane transport; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0098655 cation transmembrane transport; GO:0098656 anion transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098771 inorganic ion homeostasis; GO:1902001 fatty acid transmembrane transport; GO:1902603 carnitine transmembrane transport; GO:1902616 acyl carnitine transmembrane transport; GO:1903825 organic acid transmembrane transport; GO:1903830 magnesium ion transmembrane transport; GO:1905039 carboxylic acid transmembrane transport; GO:1990542 mitochondrial transmembrane transport; GO:1990616 magnesium ion export from mitochondrion;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005829 cytosol; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0005215 transporter activity; GO:0005476 carnitine:acyl carnitine antiporter activity; GO:0008324 cation transmembrane transporter activity; GO:0008519 ammonium transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015095 magnesium ion transmembrane transporter activity; GO:0015101 organic cation transmembrane transporter activity; GO:0015226 carnitine transmembrane transporter activity; GO:0015227 acyl carnitine transmembrane transporter activity; GO:0015291 secondary active transmembrane transporter activity; GO:0015297 antiporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015651 quaternary ammonium group transmembrane transporter activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0046873 metal ion transmembrane transporter activity; GO:0072349 modified amino acid transmembrane transporter activity;",null,null,"C","KOG0758","Mitochondrial carnitine-acylcarnitine carrier protein","WP143 FATTY ACID BETAOXIDATION;WP4742 KETOGENESIS AND KETOLYSIS;WP368 MITOCHONDRIAL LONG CHAIN FATTY ACID BETAOXIDATION;WP4321 THERMOGENESIS","http://www.wikipathways.org/instance/WP143_r116506;http://www.wikipathways.org/instance/WP4742_r119118;http://www.wikipathways.org/instance/WP368_r117795;http://www.wikipathways.org/instance/WP4321_r106178",null,"R-HSA-1430728 Metabolism;R-HSA-200425 Carnitine metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-200425;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O43776","Asparagine--tRNA ligase"," cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1","NARS1",0.951567109,0.048891057,"nochange",147120,144352,143852,140827,139785,133628,1.039027077,1.019478226,1.015947003,0.994583104,0.987224035,0.943740554,"cytoplasm","K01893","NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]","hsa00970 Aminoacyl-tRNA biosynthesis","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006421 asparaginyl-tRNA aminoacylation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016070 RNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004812 aminoacyl-tRNA ligase activity; GO:0004816 asparagine-tRNA ligase activity; GO:0016874 ligase activity; GO:0016875 ligase activity"," forming carbon-oxygen bonds; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF01336; PF00152","PF01336 OB-fold nucleic acid binding domain; PF00152 tRNA synthetases class II (D"," K and N) ","J","KOG0555","Asparaginyl-tRNA synthetase","WP3613 PHOTODYNAMIC THERAPYINDUCED UNFOLDED PROTEIN RESPONSE","http://www.wikipathways.org/instance/WP3613_r106539",null,"R-HSA-379716 Cytosolic tRNA aminoacylation;R-HSA-379724 tRNA Aminoacylation;R-HSA-392499 Metabolism of proteins;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-379716;https://reactome.org/PathwayBrowser/#/R-HSA-379724;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["O43791","Speckle-type POZ protein OS=Homo sapiens OX=9606 GN=SPOP PE=1 SV=1","SPOP",1.763834624,0.019470393,"nochange",2404.28,2286.3,1516.13,3534.22,4023.02,3390.37,0.840935694,0.799670287,0.530290912,1.236150427,1.407116108,1.185836571,"nucleus","K10523","SPOP; speckle-type POZ protein","hsa04340 Hedgehog signaling pathway","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000209 protein polyubiquitination; GO:0001654 eye development; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0003002 regionalization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006515 protein quality control for misfolded or incompletely synthesized proteins; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007275 multicellular organism development; GO:0007350 blastoderm segmentation; GO:0007365 periodic partitioning; GO:0007367 segment polarity determination; GO:0007389 pattern specification process; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008589 regulation of smoothened signaling pathway; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016567 protein ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0031648 protein destabilization; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033157 regulation of intracellular protein transport; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0035282 segmentation; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036211 protein modification process; GO:0042067 establishment of ommatidial planar polarity; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042308 negative regulation of protein import into nucleus; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045879 negative regulation of smoothened signaling pathway; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046823 negative regulation of nucleocytoplasmic transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0051788 response to misfolded protein; GO:0051865 protein autoubiquitination; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0071218 cellular response to misfolded protein; GO:0071310 cellular response to organic substance; GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0090317 negative regulation of intracellular protein transport; GO:0090596 sensory organ morphogenesis; GO:1900180 regulation of protein localization to nucleus; GO:1900181 negative regulation of protein localization to nucleus; GO:1901044 protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903828 negative regulation of protein localization; GO:1904035 regulation of epithelial cell apoptotic process; GO:1904037 positive regulation of epithelial cell apoptotic process; GO:1904589 regulation of protein import; GO:1904590 negative regulation of protein import; GO:1904950 negative regulation of establishment of protein localization; GO:1905897 regulation of response to endoplasmic reticulum stress; GO:1905898 positive regulation of response to endoplasmic reticulum stress; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000674 regulation of type B pancreatic cell apoptotic process; GO:2000676 positive regulation of type B pancreatic cell apoptotic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0019005 SCF ubiquitin ligase complex; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031463 Cul3-RING ubiquitin ligase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0044389 ubiquitin-like protein ligase binding; GO:0046983 protein dimerization activity;","PF00917; PF00651","PF00917 MATH domain; PF00651 BTB/POZ domain","DR","KOG1987","Speckle-type POZ protein SPOP and related proteins with TRAF"," MATH and BTB/POZ domains","WP4249 HEDGEHOG SIGNALING PATHWAY WP4249;WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP4249_r117749;http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-162582 Signal Transduction;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5632684 Hedgehog 'on' state","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-5358351;https://reactome.org/PathwayBrowser/#/R-HSA-5632684","UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["O43805","Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2","SSNA1",0.533335725,0.107276804,"nochange",3952.06,2774.87,3864.56,1081.29,3241.46,1326.07,1.460092818,1.025178707,1.427765849,0.399483754,1.197560884,0.489917988,"cytoplasm","K16780",null,null,"GO:0000086 G2/M transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010564 regulation of cell cycle process; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042073 intraciliary transport; GO:0043113 receptor clustering; GO:0044085 cellular component biogenesis; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044782 cilium organization; GO:0044839 cell cycle G2/M phase transition; GO:0046907 intracellular transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051668 localization within membrane; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060271 cilium assembly; GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0097711 ciliary basal body-plasma membrane docking; GO:0099111 microtubule-based transport; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0140056 organelle localization by membrane tethering; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1903047 mitotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005929 cilium; GO:0015630 microtubule cytoskeleton; GO:0036064 ciliary basal body; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;",{"$nulls":5},"WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP4352_r102218",null,"R-HSA-1640170 Cell Cycle;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition;R-HSA-380259 Loss of Nlp from mitotic centrosomes;R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes;R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome;R-HSA-380287 Centrosome maturation;R-HSA-380320 Recruitment of NuMA to mitotic centrosomes;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-5617833 Cilium Assembly;R-HSA-5620912 Anchoring of the basal body to the plasma membrane;R-HSA-68877 Mitotic Prometaphase;R-HSA-68886 M Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-8854518 AURKA Activation by TPX2","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-2565942;https://reactome.org/PathwayBrowser/#/R-HSA-380259;https://reactome.org/PathwayBrowser/#/R-HSA-380270;https://reactome.org/PathwayBrowser/#/R-HSA-380284;https://reactome.org/PathwayBrowser/#/R-HSA-380287;https://reactome.org/PathwayBrowser/#/R-HSA-380320;https://reactome.org/PathwayBrowser/#/R-HSA-453274;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620912;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69275;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-8854518"]
["O43808","Peroxisomal membrane protein PMP34 OS=Homo sapiens OX=9606 GN=SLC25A17 PE=1 SV=1","SLC25A17",0.600066496,1.15555E-4,"down",10574.7,10374,10030.7,5994.76,6579.14,6015.8,1.279994997,1.255701637,1.214147523,0.725624633,0.796359829,0.728171381,"plasma membrane","K13354","SLC25A17; solute carrier family 25 (peroxisomal adenine nucleotide transporter)"," member 17","hsa04146 Peroxisome","GO:0001561 fatty acid alpha-oxidation; GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006820 anion transport; GO:0006839 mitochondrial transport; GO:0006855 xenobiotic transmembrane transport; GO:0006862 nucleotide transport; GO:0006869 lipid transport; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0015695 organic cation transport; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015748 organophosphate ester transport; GO:0015849 organic acid transport; GO:0015858 nucleoside transport; GO:0015865 purine nucleotide transport; GO:0015866 ADP transport; GO:0015867 ATP transport; GO:0015868 purine ribonucleotide transport; GO:0015880 coenzyme A transport; GO:0015908 fatty acid transport; GO:0015931 nucleobase-containing compound transport; GO:0016042 lipid catabolic process; GO:0016054 organic acid catabolic process; GO:0019395 fatty acid oxidation; GO:0019752 carboxylic acid metabolic process; GO:0030258 lipid modification; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0034220 ion transmembrane transport; GO:0034440 lipid oxidation; GO:0035349 coenzyme A transmembrane transport; GO:0035350 FAD transmembrane transport; GO:0035352 NAD transmembrane transport; GO:0042221 response to chemical; GO:0043132 NAD transport; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0046942 carboxylic acid transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051503 adenine nucleotide transport; GO:0055085 transmembrane transport; GO:0071106 adenosine 3'","5'-bisphosphate transmembrane transport; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072329 monocarboxylic acid catabolic process; GO:0072530 purine-containing compound transmembrane transport; GO:0080121 AMP transport; GO:0098655 cation transmembrane transport; GO:0098656 anion transmembrane transport; GO:1901264 carbohydrate derivative transport; GO:1901575 organic substance catabolic process; GO:1901679 nucleotide transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005779 integral component of peroxisomal membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031231 intrinsic component of peroxisomal membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031903 microbody membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle;","GO:0000295 adenine nucleotide transmembrane transporter activity; GO:0005215 transporter activity; GO:0005346 purine ribonucleotide transmembrane transporter activity; GO:0005347 ATP transmembrane transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008324 cation transmembrane transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015101 organic cation transmembrane transporter activity; GO:0015215 nucleotide transmembrane transporter activity; GO:0015216 purine nucleotide transmembrane transporter activity; GO:0015217 ADP transmembrane transporter activity; GO:0015228 coenzyme A transmembrane transporter activity; GO:0015230 FAD transmembrane transporter activity; GO:0015605 organophosphate ester transmembrane transporter activity; GO:0015932 nucleobase-containing compound transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0044610 FMN transmembrane transporter activity; GO:0051087 chaperone binding; GO:0051724 NAD transmembrane transporter activity; GO:0071077 adenosine 3'","5'-bisphosphate transmembrane transporter activity; GO:0080122 AMP transmembrane transporter activity; GO:1901505 carbohydrate derivative transmembrane transporter activity;",null,null,"C","KOG0769","Predicted mitochondrial carrier protein",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-389599 Alpha-oxidation of phytanate;R-HSA-390918 Peroxisomal lipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9603798 Class I peroxisomal membrane protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-389599;https://reactome.org/PathwayBrowser/#/R-HSA-390918;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9603798;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["O43809","Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1","NUDT21",1.407638717,0.006757324,"up",39196.5,42359.5,45001.9,63319.1,61465.8,53362.9,0.771823435,0.834106484,0.88613833,1.246824723,1.210331149,1.05077588,"mitochondria","K14397","NUDT21; cleavage and polyadenylation specificity factor subunit 5","hsa03015 mRNA surveillance pathway","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006353 DNA-templated transcription"," termination; GO:0006366 transcription by RNA polymerase II; GO:0006369 termination of RNA polymerase II transcription; GO:0006378 mRNA polyadenylation; GO:0006379 mRNA cleavage; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031437 regulation of mRNA cleavage; GO:0031439 positive regulation of mRNA cleavage; GO:0031440 regulation of mRNA 3'-end processing; GO:0031442 positive regulation of mRNA 3'-end processing; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043631 RNA polyadenylation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050684 regulation of mRNA processing; GO:0050685 positive regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051262 protein tetramerization; GO:0051290 protein heterotetramerization; GO:0051291 protein heterooligomerization; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0097659 nucleic acid-templated transcription; GO:0098787 mRNA cleavage involved in mRNA processing; GO:0098789 pre-mRNA cleavage required for polyadenylation; GO:0110104 mRNA alternative polyadenylation; GO:1900363 regulation of mRNA polyadenylation; GO:1900365 positive regulation of mRNA polyadenylation; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901532 regulation of hematopoietic progenitor cell differentiation; GO:1901534 positive regulation of hematopoietic progenitor cell differentiation; GO:1901576 organic substance biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903313 positive regulation of mRNA metabolic process; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1905456 regulation of lymphoid progenitor cell differentiation; GO:1905458 positive regulation of lymphoid progenitor cell differentiation; GO:1990120 messenger ribonucleoprotein complex assembly; GO:2000026 regulation of multicellular organismal development; GO:2000736 regulation of stem cell differentiation; GO:2000738 positive regulation of stem cell differentiation; GO:2000973 regulation of pro-B cell differentiation; GO:2000975 positive regulation of pro-B cell differentiation;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005847 mRNA cleavage and polyadenylation specificity factor complex; GO:0005849 mRNA cleavage factor complex; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042382 paraspeckles; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003682 chromatin binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0042826 histone deacetylase binding; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF13869","PF13869 Nucleotide hydrolase","A","KOG1689","mRNA cleavage factor I subunit","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75067 Processing of Capped Intronless Pre-mRNA;R-HSA-77595 Processing of Intronless Pre-mRNAs;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75067;https://reactome.org/PathwayBrowser/#/R-HSA-77595;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","DNA REPAIR;E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["O43813","Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1","LANCL1",1.027661991,0.295293146,"nochange",43392.6,45543.1,46394.4,45929.3,45741.7,47402.6,0.948804991,0.995826951,1.014441132,1.004271444,1.000169458,1.036486024,"cytoplasm","K25210","LANCL1; glutathione transferase [EC:2.5.1.18]","hsa00480 Glutathione metabolism; hsa01100 Metabolic pathways","GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0009987 cellular process; GO:0023052 signaling; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation;","GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0071944 cell periphery;","GO:0004888 transmembrane signaling receptor activity; GO:0004930 G protein-coupled receptor activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding; GO:0033218 amide binding; GO:0038023 signaling receptor activity; GO:0042277 peptide binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043295 glutathione binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0050750 low-density lipoprotein particle receptor binding; GO:0060089 molecular transducer activity; GO:0070325 lipoprotein particle receptor binding; GO:0072341 modified amino acid binding; GO:1900750 oligopeptide binding; GO:1901681 sulfur compound binding;",null,null,"V","KOG2787","Lanthionine synthetase C-like protein 1"]
["O43815","Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4","STRN",1.144189916,0.004255435,"up",80936.4,87261.7,84133,97471.6,96366.1,94877,0.897555068,0.967700331,0.933004193,1.080924388,1.068664797,1.052151223,"nucleus","K17608",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000165 MAPK cascade; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007043 cell-cell junction assembly; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007254 JNK cascade; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009629 response to gravity; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0016310 phosphorylation; GO:0016331 morphogenesis of embryonic epithelium; GO:0016358 dendrite development; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032355 response to estradiol; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0033043 regulation of organelle organization; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway; GO:0033146 regulation of intracellular estrogen receptor signaling pathway; GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035330 regulation of hippo signaling; GO:0035331 negative regulation of hippo signaling; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042332 gravitaxis; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043297 apical junction assembly; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043547 positive regulation of GTPase activity; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045216 cell-cell junction organization; GO:0045595 regulation of cell differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051403 stress-activated MAPK cascade; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070830 bicellular tight junction assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0120036 plasma membrane bounded cell projection organization; GO:0198738 cell-cell signaling by wnt; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903358 regulation of Golgi organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000736 regulation of stem cell differentiation; GO:2001135 regulation of endocytic recycling; GO:2001137 positive regulation of endocytic recycling; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005923 bicellular tight junction; GO:0012505 endomembrane system; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0030054 cell junction; GO:0030425 dendrite; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032279 asymmetric synapse; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043296 apical junction complex; GO:0044297 cell body; GO:0044309 neuron spine; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0070013 intracellular organelle lumen; GO:0070160 tight junction; GO:0071944 cell periphery; GO:0090443 FAR/SIN/STRIPAK complex; GO:0097060 synaptic membrane; GO:0097447 dendritic tree; GO:0098590 plasma membrane region; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection;","GO:0003700 DNA-binding transcription factor activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0008134 transcription factor binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0019904 protein domain specific binding; GO:0030331 estrogen receptor binding; GO:0031267 small GTPase binding; GO:0044877 protein-containing complex binding; GO:0048306 calcium-dependent protein binding; GO:0051020 GTPase binding; GO:0051427 hormone receptor binding; GO:0051721 protein phosphatase 2A binding; GO:0070016 armadillo repeat domain binding; GO:0140110 transcription regulator activity;",null,null,"D","KOG0642","Cell-cycle nuclear protein"," contains WD-40 repeats","WP4205 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA","http://www.wikipathways.org/instance/WP4205_r118937",null,"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9009391 Extra-nuclear estrogen signaling;R-HSA-9671555 Signaling by PDGFR in disease;R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins;R-HSA-9700206 Signaling by ALK in cancer;R-HSA-9700645 ALK mutants bind TKIs;R-HSA-9725370 Signaling by ALK fusions and activated point mutants","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-199418;https://reactome.org/PathwayBrowser/#/R-HSA-2219528;https://reactome.org/PathwayBrowser/#/R-HSA-2219530;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-6811558;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9009391;https://reactome.org/PathwayBrowser/#/R-HSA-9671555;https://reactome.org/PathwayBrowser/#/R-HSA-9673766;https://reactome.org/PathwayBrowser/#/R-HSA-9700206;https://reactome.org/PathwayBrowser/#/R-HSA-9700645;https://reactome.org/PathwayBrowser/#/R-HSA-9725370","KRAS SIGNALING UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP"]
["O43818","U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1","RRP9",0.867928618,0.000460404,"down",49445.2,48768.7,48511.3,41428.1,43081,42837.9,1.082456375,1.067646409,1.062011397,0.906945688,0.943131044,0.937809088,"nucleus","K14793",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005732 sno(s)RNA-containing ribonucleoprotein complex; GO:0030684 preribosome; GO:0031428 box C/D RNP complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032040 small-subunit processome; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0030515 snoRNA binding; GO:0034511 U3 snoRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG0299","U3 snoRNP-associated protein (contains WD40 repeats)",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MTORC1 SIGNALING;MYC TARGETS V1;MYC TARGETS V2;UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["O43819","Protein SCO2 homolog"," mitochondrial OS=Homo sapiens OX=9606 GN=SCO2 PE=1 SV=3","SCO2",0.993213994,0.893571083,"nochange",5499.97,5081.64,5722.53,5540.34,5100.83,5552.33,1.015452814,0.938217052,1.056543798,1.022906279,0.941760079,1.025119978,"mitochondria","K23755","SCO2; protein SCO2","hsa05230 Central carbon metabolism in cancer","GO:0001654 eye development; GO:0001701 in utero embryonic development; GO:0003008 system process; GO:0003012 muscle system process; GO:0006091 generation of precursor metabolites and energy; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008535 respiratory chain complex IV assembly; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0014823 response to activity; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0017004 cytochrome complex assembly; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0033617 mitochondrial cytochrome c oxidase assembly; GO:0042592 homeostatic process; GO:0043009 chordate embryonic development; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0045333 cellular respiration; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0055065 metal ion homeostasis; GO:0055070 copper ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0098771 inorganic ion homeostasis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0030016 myofibril; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031304 intrinsic component of mitochondrial inner membrane; GO:0031305 integral component of mitochondrial inner membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0070013 intracellular organelle lumen; GO:0098573 intrinsic component of mitochondrial membrane; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005507 copper ion binding; GO:0015035 protein-disulfide reductase activity; GO:0015036 disulfide oxidoreductase activity; GO:0016491 oxidoreductase activity; GO:0016667 oxidoreductase activity"," acting on a sulfur group of donors; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding;",null,null,"C","KOG2792","Putative cytochrome C oxidase assembly protein","WP3286 COPPER HOMEOSTASIS;WP4922 MITOCHONDRIAL COMPLEX IV ASSEMBLY;WP5046 NAD METABOLISM IN ONCOGENEINDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTIONASSOCIATED SENESCENCE","http://www.wikipathways.org/instance/WP3286_r106367;http://www.wikipathways.org/instance/WP4922_r117792;http://www.wikipathways.org/instance/WP5046_r118987",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5628897 TP53 Regulates Metabolic Genes;R-HSA-611105 Respiratory electron transport;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953897 Cellular responses to stimuli;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5628897;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9711123"]
["O43820","Hyaluronidase-3 OS=Homo sapiens OX=9606 GN=HYAL3 PE=1 SV=1","HYAL3",0.616534412,6.639893E-3,"down",2898.35,3278.08,3225.9,1643.51,1937.54,2215.81,1.144146497,1.294047907,1.27344944,0.648788521,0.76485918,0.874708455,"extracellular","K01197","hya; hyaluronoglucosaminidase [EC:3.2.1.35]","hsa00531 Glycosaminoglycan degradation; hsa04142 Lysosome; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0001501 skeletal system development; GO:0001552 ovarian follicle atresia; GO:0003006 developmental process involved in reproduction; GO:0006022 aminoglycan metabolic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006082 organic acid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0007275 multicellular organism development; GO:0007338 single fertilization; GO:0007341 penetration of zona pellucida; GO:0007548 sex differentiation; GO:0008152 metabolic process; GO:0008406 gonad development; GO:0008585 female gonad development; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009566 fertilization; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009628 response to abiotic stimulus; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010224 response to UV-B; GO:0016054 organic acid catabolic process; GO:0017157 regulation of exocytosis; GO:0017158 regulation of calcium ion-dependent exocytosis; GO:0019752 carboxylic acid metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0030203 glycosaminoglycan metabolic process; GO:0030212 hyaluronan metabolic process; GO:0030214 hyaluronan catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0034097 response to cytokine; GO:0034612 response to tumor necrosis factor; GO:0034644 cellular response to UV; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045137 development of primary sexual characteristics; GO:0045921 positive regulation of exocytosis; GO:0045956 positive regulation of calcium ion-dependent exocytosis; GO:0046395 carboxylic acid catabolic process; GO:0046545 development of primary female sexual characteristics; GO:0046660 female sex differentiation; GO:0046677 response to antibiotic; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051216 cartilage development; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060046 regulation of acrosome reaction; GO:0060627 regulation of vesicle-mediated transport; GO:0061448 connective tissue development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0070555 response to interleukin-1; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071356 cellular response to tumor necrosis factor; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071493 cellular response to UV-B; GO:0071704 organic substance metabolic process; GO:0080154 regulation of fertilization; GO:0104004 cellular response to environmental stimulus; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1903305 regulation of regulated secretory pathway; GO:1903307 positive regulation of regulated secretory pathway; GO:1903510 mucopolysaccharide metabolic process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1905516 positive regulation of fertilization; GO:1905939 regulation of gonad development; GO:1905940 negative regulation of gonad development; GO:2000026 regulation of multicellular organismal development; GO:2000194 regulation of female gonad development; GO:2000195 negative regulation of female gonad development; GO:2000241 regulation of reproductive process; GO:2000242 negative regulation of reproductive process; GO:2000243 positive regulation of reproductive process; GO:2000344 positive regulation of acrosome reaction; GO:2000354 regulation of ovarian follicle development; GO:2000355 negative regulation of ovarian follicle development; GO:2000367 regulation of acrosomal vesicle exocytosis; GO:2000368 positive regulation of acrosomal vesicle exocytosis;","GO:0000323 lytic vacuole; GO:0001669 acrosomal vesicle; GO:0002080 acrosomal membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005768 endosome; GO:0005769 early endosome; GO:0005773 vacuole; GO:0005783 endoplasmic reticulum; GO:0005929 cilium; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031514 motile cilium; GO:0031982 vesicle; GO:0036126 sperm flagellum; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097225 sperm midpiece; GO:0097708 intracellular vesicle; GO:0097729 9+2 motile cilium; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004415 hyalurononglucosaminidase activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0015929 hexosaminidase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0033906 hyaluronoglucuronidase activity;","PF01630","PF01630 Hyaluronidase",{"$nulls":6},"R-HSA-1430728 Metabolism;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism;R-HSA-2024101 CS/DS degradation;R-HSA-2142845 Hyaluronan metabolism;R-HSA-2160916 Hyaluronan uptake and degradation;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-1793185;https://reactome.org/PathwayBrowser/#/R-HSA-2024101;https://reactome.org/PathwayBrowser/#/R-HSA-2142845;https://reactome.org/PathwayBrowser/#/R-HSA-2160916;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["O43822","Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1","CFAP410",0.482671349,3.94514E-4,"down",2779.97,2706.32,2874.43,1423.57,1177.58,1434.33,1.345559123,1.309911102,1.391279586,0.68903535,0.569971443,0.694243397,"mitochondria","K23456",null,null,"GO:0000003 reproduction; GO:0002165 instar larval or pupal development; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007275 multicellular organism development; GO:0007320 insemination; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007552 metamorphosis; GO:0007618 mating; GO:0007620 copulation; GO:0008219 cell death; GO:0008360 regulation of cell shape; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0010623 programmed cell death involved in cell development; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022612 gland morphogenesis; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033554 cellular response to stress; GO:0035070 salivary gland histolysis; GO:0035071 salivary gland cell autophagic cell death; GO:0035272 exocrine system development; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0044782 cilium organization; GO:0046692 sperm competition; GO:0048102 autophagic cell death; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048707 instar larval or pupal morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0060033 anatomical structure regression; GO:0060271 cilium assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization;","GO:0001750 photoreceptor outer segment; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0032391 photoreceptor connecting cilium; GO:0035869 ciliary transition zone; GO:0036064 ciliary basal body; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0097730 non-motile cilium; GO:0097731 9+0 non-motile cilium; GO:0097733 photoreceptor cell cilium; GO:0120025 plasma membrane bounded cell projection;",{"$nulls":3},"S","KOG2123","Uncharacterized conserved protein","WP4803 CILIOPATHIES","http://www.wikipathways.org/instance/WP4803_r110008"]
["O43823","A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1","AKAP8",1.348092542,0.002335997,"up",26189.1,30368.6,28765.3,38722.2,38375.1,37926,0.784314959,0.90948323,0.861467369,1.159658052,1.149263051,1.135813339,"nucleus","K16525",null,null,"GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0001101 response to acid chemical; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0002237 response to molecule of bacterial origin; GO:0006323 DNA packaging; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007076 mitotic chromosome condensation; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0023052 signaling; GO:0030261 chromosome condensation; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031063 regulation of histone deacetylation; GO:0031065 positive regulation of histone deacetylation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032496 response to lipopolysaccharide; GO:0032680 regulation of tumor necrosis factor production; GO:0032720 negative regulation of tumor necrosis factor production; GO:0032870 cellular response to hormone stimulus; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033127 regulation of histone phosphorylation; GO:0033993 response to lipid; GO:0034694 response to prostaglandin; GO:0034695 response to prostaglandin E; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0043207 response to external biotic stimulus; GO:0044770 cell cycle phase transition; GO:0044839 cell cycle G2/M phase transition; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070542 response to fatty acid; GO:0070887 cellular response to chemical stimulus; GO:0071103 DNA conformation change; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071229 cellular response to acid chemical; GO:0071310 cellular response to organic substance; GO:0071379 cellular response to prostaglandin stimulus; GO:0071380 cellular response to prostaglandin E stimulus; GO:0071396 cellular response to lipid; GO:0071398 cellular response to fatty acid; GO:0071495 cellular response to endogenous stimulus; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090311 regulation of protein deacetylation; GO:0090312 positive regulation of protein deacetylation; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902275 regulation of chromatin organization; GO:1903047 mitotic cell cycle process; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production; GO:1905269 positive regulation of chromatin organization; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000793 condensed chromosome; GO:0001939 female pronucleus; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0016363 nuclear matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045120 pronucleus; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008270 zinc ion binding; GO:0019899 enzyme binding; GO:0034237 protein kinase A regulatory subunit binding; GO:0042826 histone deacetylase binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051018 protein kinase A binding; GO:0051059 NF-kappaB binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",{"$nulls":5},"WP35 G PROTEIN SIGNALING PATHWAYS","http://www.wikipathways.org/instance/WP35_r117729"]
["O43826","Glucose-6-phosphate exchanger SLC37A4 OS=Homo sapiens OX=9606 GN=SLC37A4 PE=1 SV=1","SLC37A4",0.716722293,0.015490278,"nochange",40712.2,33599,36757.9,28901.2,27175.5,23529,1.281098499,1.057266089,1.156667792,0.909439527,0.855136599,0.740391494,"plasma membrane","K08171","SLC37A4; MFS transporter"," OPA family"," solute carrier family 37 (glycerol-6-phosphate transporter)"," member 4","hsa04973 Carbohydrate digestion and absorption","GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006006 glucose metabolic process; GO:0006094 gluconeogenesis; GO:0006810 transport; GO:0006811 ion transport; GO:0006817 phosphate ion transport; GO:0006820 anion transport; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0015698 inorganic anion transport; GO:0015711 organic anion transport; GO:0015712 hexose phosphate transport; GO:0015748 organophosphate ester transport; GO:0015760 glucose-6-phosphate transport; GO:0016051 carbohydrate biosynthetic process; GO:0019318 hexose metabolic process; GO:0019319 hexose biosynthetic process; GO:0033500 carbohydrate homeostasis; GO:0034220 ion transmembrane transport; GO:0035435 phosphate ion transmembrane transport; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046364 monosaccharide biosynthetic process; GO:0048878 chemical homeostasis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0098656 anion transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098661 inorganic anion transmembrane transport; GO:1901264 carbohydrate derivative transport; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0005215 transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015114 phosphate ion transmembrane transporter activity; GO:0015119 hexose phosphate transmembrane transporter activity; GO:0015152 glucose-6-phosphate transmembrane transporter activity; GO:0015291 secondary active transmembrane transporter activity; GO:0015297 antiporter activity; GO:0015301 anion:anion antiporter activity; GO:0015315 organophosphate:inorganic phosphate antiporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015526 hexose-phosphate:inorganic phosphate antiporter activity; GO:0015605 organophosphate ester transmembrane transporter activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0061513 glucose 6-phosphate:inorganic phosphate antiporter activity; GO:1901505 carbohydrate derivative transmembrane transporter activity;",null,null,"G","KOG2533","Permease of the major facilitator superfamily",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1643685 Disease;R-HSA-3229121 Glycogen storage diseases;R-HSA-3229133 Glycogen storage disease type Ib (SLC37A4);R-HSA-5663084 Diseases of carbohydrate metabolism;R-HSA-5668914 Diseases of metabolism;R-HSA-70263 Gluconeogenesis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-3229121;https://reactome.org/PathwayBrowser/#/R-HSA-3229133;https://reactome.org/PathwayBrowser/#/R-HSA-5663084;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-70263;https://reactome.org/PathwayBrowser/#/R-HSA-70326;https://reactome.org/PathwayBrowser/#/R-HSA-71387","GLYCOLYSIS;HYPOXIA;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["O43829","Zinc finger and BTB domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZBTB14 PE=1 SV=2","ZBTB14",0.780083619,0.408579242,"nochange",2213.01,1467.98,"NA",1067.14,1325.18,1914.9,1.385172648,0.918841643,"NA",0.667946887,0.829459917,1.198578906,"nucleus","K24804",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001568 blood vessel development; GO:0001944 vasculature development; GO:0003170 heart valve development; GO:0003205 cardiac chamber development; GO:0003279 cardiac septum development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007275 multicellular organism development; GO:0007507 heart development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060976 coronary vasculature development; GO:0065007 biological regulation; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016234 inclusion body; GO:0016235 aggresome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00651; PF00096","PF00651 BTB/POZ domain; PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["O43837","Isocitrate dehydrogenase [NAD] subunit beta"," mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2","IDH3B",0.828178143,2.388458E-3,"down",37903.3,35447.9,38345.3,31445.2,30124.7,30934.7,1.113705068,1.041558542,1.126692266,0.92394801,0.885148023,0.908948091,"mitochondria","K00030","IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]","hsa01210 2-Oxocarboxylic acid metabolism; hsa01200 Carbon metabolism; hsa00020 Citrate cycle (TCA cycle); hsa01230 Biosynthesis of amino acids; hsa01100 Metabolic pathways","GO:0002165 instar larval or pupal development; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006099 tricarboxylic acid cycle; GO:0006101 citrate metabolic process; GO:0006102 isocitrate metabolic process; GO:0006103 2-oxoglutarate metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006734 NADH metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007552 metamorphosis; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009060 aerobic respiration; GO:0009117 nucleotide metabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010623 programmed cell death involved in cell development; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0012502 induction of programmed cell death; GO:0014070 response to organic cyclic compound; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016999 antibiotic metabolic process; GO:0019362 pyridine nucleotide metabolic process; GO:0019637 organophosphate metabolic process; GO:0019674 NAD metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022612 gland morphogenesis; GO:0022900 electron transport chain; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0035070 salivary gland histolysis; GO:0035071 salivary gland cell autophagic cell death; GO:0035072 ecdysone-mediated induction of salivary gland cell autophagic cell death; GO:0035075 response to ecdysone; GO:0035078 induction of programmed cell death by ecdysone; GO:0035081 induction of programmed cell death by hormones; GO:0035272 exocrine system development; GO:0036314 response to sterol; GO:0042221 response to chemical; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043436 oxoacid metabolic process; GO:0043648 dicarboxylic acid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0048102 autophagic cell death; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048707 instar larval or pupal morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060033 anatomical structure regression; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072350 tricarboxylic acid metabolic process; GO:0072524 pyridine-containing compound metabolic process; GO:0097305 response to alcohol; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901654 response to ketone; GO:1901700 response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005962 mitochondrial isocitrate dehydrogenase complex (NAD+); GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045239 tricarboxylic acid cycle enzyme complex; GO:0045242 isocitrate dehydrogenase complex (NAD+); GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0004448 isocitrate dehydrogenase activity; GO:0004449 isocitrate dehydrogenase (NAD+) activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor;","PF00180","PF00180 Isocitrate/isopropylmalate dehydrogenase","E","KOG0784","Isocitrate dehydrogenase"," gamma subunit","WP78 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE","http://www.wikipathways.org/instance/WP78_r119082",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-71403 Citric acid cycle (TCA cycle);R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-71403;https://reactome.org/PathwayBrowser/#/R-HSA-71406","FATTY ACID METABOLISM;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O43847","Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3","NRDC",0.891525208,0.032895871,"nochange",38945.7,42267.4,39510.8,34111.4,37114.4,36402.6,1.023305655,1.110583953,1.038153765,0.896283506,0.9751879,0.95648522,"mitochondria","K01411",null,null,"GO:0006457 protein folding; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0007528 neuromuscular junction development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0040011 locomotion; GO:0042176 regulation of protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0044238 primary metabolic process; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0051043 regulation of membrane protein ectodomain proteolysis; GO:0051044 positive regulation of membrane protein ectodomain proteolysis; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051674 localization of cell; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0061077 chaperone-mediated protein folding; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0009986 cell surface; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0101031 chaperone complex;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004222 metalloendopeptidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008237 metallopeptidase activity; GO:0016787 hydrolase activity; GO:0019838 growth factor binding; GO:0042562 hormone binding; GO:0044183 protein folding chaperone; GO:0048408 epidermal growth factor binding; GO:0140096 catalytic activity"," acting on a protein;","PF05193","PF05193 Peptidase M16 inactive domain","O","KOG0959","N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases"," insulinase superfamily"]
["O43852","Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2","CALU",1.141634508,0.011686132,"nochange",75809.2,77647,72659.6,89582.2,82739.8,85819.6,0.939283943,0.962054478,0.900260068,1.109932858,1.025154804,1.063313849,"extracellular","K23901",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006265 DNA topological change; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007549 dosage compensation; GO:0008152 metabolic process; GO:0009047 dosage compensation by hyperactivation of X chromosome; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010911 regulation of isomerase activity; GO:0010912 positive regulation of isomerase activity; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032781 positive regulation of ATP-dependent activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043462 regulation of ATP-dependent activity; GO:0043687 post-translational protein modification; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity; GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0098772 molecular function regulator;","PF13202; PF13833","PF13202 EF hand; PF13833 EF-hand domain pair","TU","KOG4223","Reticulocalbin"," calumenin"," DNA supercoiling factor"," and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily)","WP3413 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3413_r116601;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-8957275 Post-translational protein phosphorylation","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-381426;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005;https://reactome.org/PathwayBrowser/#/R-HSA-8957275","EPITHELIAL MESENCHYMAL TRANSITION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"]
["O43861","Probable phospholipid-transporting ATPase IIB OS=Homo sapiens OX=9606 GN=ATP9B PE=2 SV=4","ATP9B",0.7135077,0.072505992,"nochange",5633.87,5280.24,4195.79,4149.3,2880.53,3751.2,1.305600842,1.223650135,0.972338189,0.961564532,0.667538014,0.869308287,"plasma membrane","K01530",null,null,"GO:0000003 reproduction; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006897 endocytosis; GO:0007275 multicellular organism development; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015914 phospholipid transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034204 lipid translocation; GO:0045332 phospholipid translocation; GO:0048193 Golgi vesicle transport; GO:0048856 anatomical structure development; GO:0051179 localization; GO:0051234 establishment of localization; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071702 organic substance transport; GO:0071840 cellular component organization or biogenesis; GO:0097035 regulation of membrane lipid distribution; GO:0098657 import into cell;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0055037 recycling endosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0005319 lipid transporter activity; GO:0005548 phospholipid transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity;","PF00702","PF00702 haloacid dehalogenase-like hydrolase","P","KOG0210","P-type ATPase",{"$nulls":3},"R-HSA-382551 Transport of small molecules;R-HSA-936837 Ion transport by P-type ATPases;R-HSA-983712 Ion channel transport","https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-936837;https://reactome.org/PathwayBrowser/#/R-HSA-983712"]
["O43865","S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2","AHCYL1",0.354430744,0.003940708,"down",5235.49,5858.9,8039.08,1797.76,2673.6,2310.13,1.212154678,1.356490614,1.86126006,0.416229082,0.619009252,0.534856315,"cytoplasm","K01251","AHCY; adenosylhomocysteinase [EC:3.13.2.1]","hsa00270 Cysteine and methionine metabolism; hsa01100 Metabolic pathways","GO:0000096 sulfur amino acid metabolic process; GO:0002028 regulation of sodium ion transport; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006378 mRNA polyadenylation; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006520 cellular amino acid metabolic process; GO:0006534 cysteine metabolic process; GO:0006555 methionine metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0008016 regulation of heart contraction; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009066 aspartate family amino acid metabolic process; GO:0009069 serine family amino acid metabolic process; GO:0009116 nucleoside metabolic process; GO:0009119 ribonucleoside metabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010243 response to organonitrogen compound; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010765 positive regulation of sodium ion transport; GO:0010959 regulation of metal ion transport; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031440 regulation of mRNA 3'-end processing; GO:0032409 regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033353 S-adenosylmethionine cycle; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0038166 angiotensin-activated signaling pathway; GO:0042044 fluid transport; GO:0042045 epithelial fluid transport; GO:0042221 response to chemical; GO:0042278 purine nucleoside metabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0043631 RNA polyadenylation; GO:0044057 regulation of system process; GO:0044070 regulation of anion transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045184 establishment of protein localization; GO:0046128 purine ribonucleoside metabolic process; GO:0046439 L-cysteine metabolic process; GO:0046483 heterocycle metabolic process; GO:0046498 S-adenosylhomocysteine metabolic process; GO:0046500 S-adenosylmethionine metabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051592 response to calcium ion; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070633 transepithelial transport; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072521 purine-containing compound metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901605 alpha-amino acid metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901657 glycosyl compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903311 regulation of mRNA metabolic process; GO:1903522 regulation of blood circulation; GO:1903779 regulation of cardiac conduction; GO:1904385 cellular response to angiotensin; GO:1990776 response to angiotensin;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045177 apical part of cell; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0098827 endoplasmic reticulum subcompartment;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;","PF05221; PF00670","PF05221 S-adenosyl-L-homocysteine hydrolase; PF00670 S-adenosyl-L-homocysteine hydrolase"," NAD binding domain","H","KOG1370","S-adenosylhomocysteine hydrolase","WP3940 ONECARBON METABOLISM AND RELATED PATHWAYS;WP2525 TRANSSULFURATION AND ONECARBON METABOLISM","http://www.wikipathways.org/instance/WP3940_r119248;http://www.wikipathways.org/instance/WP2525_r116582",null,"R-HSA-111885 Opioid Signalling;R-HSA-112040 G-protein mediated events;R-HSA-112043 PLC beta mediated events;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-1489509 DAG and IP3 signaling;R-HSA-162582 Signal Transduction;R-HSA-163685 Integration of energy metabolism;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194138 Signaling by VEGF;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029485 Role of phospholipids in phagocytosis;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871809 FCERI mediated Ca+2 mobilization;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-397014 Muscle contraction;R-HSA-418594 G alpha (i) signalling events;R-HSA-422356 Regulation of insulin secretion;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-5218921 VEGFR2 mediated cell proliferation;R-HSA-5576891 Cardiac conduction;R-HSA-5578775 Ion homeostasis;R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5663205 Infectious disease;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9658195 Leishmania infection;R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection;R-HSA-9664323 FCGR3A-mediated IL10 synthesis;R-HSA-9664433 Leishmania parasite growth and survival;R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;R-HSA-983705 Signaling by the B Cell Receptor (BCR)","https://reactome.org/PathwayBrowser/#/R-HSA-111885;https://reactome.org/PathwayBrowser/#/R-HSA-112040;https://reactome.org/PathwayBrowser/#/R-HSA-112043;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1489509;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-163685;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029485;https://reactome.org/PathwayBrowser/#/R-HSA-2454202;https://reactome.org/PathwayBrowser/#/R-HSA-2871809;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-397014;https://reactome.org/PathwayBrowser/#/R-HSA-418594;https://reactome.org/PathwayBrowser/#/R-HSA-422356;https://reactome.org/PathwayBrowser/#/R-HSA-4420097;https://reactome.org/PathwayBrowser/#/R-HSA-5218921;https://reactome.org/PathwayBrowser/#/R-HSA-5576891;https://reactome.org/PathwayBrowser/#/R-HSA-5578775;https://reactome.org/PathwayBrowser/#/R-HSA-5607763;https://reactome.org/PathwayBrowser/#/R-HSA-5607764;https://reactome.org/PathwayBrowser/#/R-HSA-5621481;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9662851;https://reactome.org/PathwayBrowser/#/R-HSA-9664323;https://reactome.org/PathwayBrowser/#/R-HSA-9664433;https://reactome.org/PathwayBrowser/#/R-HSA-983695;https://reactome.org/PathwayBrowser/#/R-HSA-983705"]
["O43909","Exostosin-like 3 OS=Homo sapiens OX=9606 GN=EXTL3 PE=1 SV=1","EXTL3",1.729439878,0.0182554,"nochange","NA",2079.67,1761.99,2943.22,3813.64,3209.02,"NA",0.753092151,0.638053556,1.065801729,1.380999077,1.162053487,"plasma membrane","K02370","EXTL3; alpha-1","4-N-acetylglucosaminyltransferase EXTL3 [EC:2.4.1.223 2.4.1.224]","hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin; hsa01100 Metabolic pathways","GO:0000271 polysaccharide biosynthetic process; GO:0001558 regulation of cell growth; GO:0005975 carbohydrate metabolic process; GO:0005976 polysaccharide metabolic process; GO:0006022 aminoglycan metabolic process; GO:0006023 aminoglycan biosynthetic process; GO:0006024 glycosaminoglycan biosynthetic process; GO:0006029 proteoglycan metabolic process; GO:0006040 amino sugar metabolic process; GO:0006044 N-acetylglucosamine metabolic process; GO:0006082 organic acid metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008589 regulation of smoothened signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0015012 heparan sulfate proteoglycan biosynthetic process; GO:0015014 heparan sulfate proteoglycan biosynthetic process"," polysaccharide chain biosynthetic process; GO:0016051 carbohydrate biosynthetic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030166 proteoglycan biosynthetic process; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030201 heparan sulfate proteoglycan metabolic process; GO:0030202 heparin metabolic process; GO:0030203 glycosaminoglycan metabolic process; GO:0030210 heparin biosynthetic process; GO:0030307 positive regulation of cell growth; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0033692 cellular polysaccharide biosynthetic process; GO:0034620 cellular response to unfolded protein; GO:0034637 cellular carbohydrate biosynthetic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034976 response to endoplasmic reticulum stress; GO:0035295 tube development; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036498 IRE1-mediated unfolded protein response; GO:0040008 regulation of growth; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044264 cellular polysaccharide metabolic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045880 positive regulation of smoothened signaling pathway; GO:0045927 positive regulation of growth; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048565 digestive tract development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051716 cellular response to stimulus; GO:0055123 digestive system development; GO:0060465 pharynx development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071704 organic substance metabolic process; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090263 positive regulation of canonical Wnt signaling pathway; GO:1901071 glucosamine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903510 mucopolysaccharide metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008194 UDP-glycosyltransferase activity; GO:0008375 acetylglucosaminyltransferase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0019899 enzyme binding; GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity;","PF09258","PF09258 Glycosyl transferase family 64 domain","T","KOG2264","Exostosin EXT1L","WP4784 PROTEOGLYCAN BIOSYNTHESIS","http://www.wikipathways.org/instance/WP4784_r111633",null,"R-HSA-2262752 Cellular responses to stress;R-HSA-381038 XBP1(S) activates chaperone genes;R-HSA-381070 IRE1alpha activates chaperones;R-HSA-381119 Unfolded Protein Response (UPR);R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-381038;https://reactome.org/PathwayBrowser/#/R-HSA-381070;https://reactome.org/PathwayBrowser/#/R-HSA-381119;https://reactome.org/PathwayBrowser/#/R-HSA-8953897"]
["O43913","Origin recognition complex subunit 5 OS=Homo sapiens OX=9606 GN=ORC5 PE=1 SV=1","ORC5",0.701588709,0.008938359,"down",9957.38,10465.7,10856.4,7913.16,7713.96,6318.21,1.122489305,1.179791905,1.223835275,0.892045646,0.869589953,0.712247916,"cytoskeleton","K02607","ORC5; origin recognition complex subunit 5","hsa04110 Cell cycle","GO:0000070 mitotic sister chromatid segregation; GO:0000082 G1/S transition of mitotic cell cycle; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006270 DNA replication initiation; GO:0006323 DNA packaging; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0007076 mitotic chromosome condensation; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0030261 chromosome condensation; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0046483 heterocycle metabolic process; GO:0048285 organelle fission; GO:0051276 chromosome organization; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process;","GO:0000228 nuclear chromosome; GO:0000808 origin recognition complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005664 nuclear origin of replication recognition complex; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003688 DNA replication origin binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0036094 small molecule binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF13191","PF13191 AAA ATPase domain","L","KOG2543","Origin recognition complex"," subunit 5","WP179 CELL CYCLE;WP466 DNA REPLICATION;WP45 G1 TO S CELL CYCLE CONTROL","http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP466_r117096;http://www.wikipathways.org/instance/WP45_r106424",null,"R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation;R-HSA-113510 E2F mediated regulation of DNA replication;R-HSA-1640170 Cell Cycle;R-HSA-176187 Activation of ATR in response to replication stress;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-68616 Assembly of the ORC complex at the origin of replication;R-HSA-68689 CDC6 association with the ORC:origin complex;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68949 Orc1 removal from chromatin;R-HSA-68962 Activation of the pre-replicative complex;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints","https://reactome.org/PathwayBrowser/#/R-HSA-113507;https://reactome.org/PathwayBrowser/#/R-HSA-113510;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-176187;https://reactome.org/PathwayBrowser/#/R-HSA-453279;https://reactome.org/PathwayBrowser/#/R-HSA-68616;https://reactome.org/PathwayBrowser/#/R-HSA-68689;https://reactome.org/PathwayBrowser/#/R-HSA-68867;https://reactome.org/PathwayBrowser/#/R-HSA-68949;https://reactome.org/PathwayBrowser/#/R-HSA-68962;https://reactome.org/PathwayBrowser/#/R-HSA-69002;https://reactome.org/PathwayBrowser/#/R-HSA-69052;https://reactome.org/PathwayBrowser/#/R-HSA-69206;https://reactome.org/PathwayBrowser/#/R-HSA-69239;https://reactome.org/PathwayBrowser/#/R-HSA-69242;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69306;https://reactome.org/PathwayBrowser/#/R-HSA-69481;https://reactome.org/PathwayBrowser/#/R-HSA-69620","G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O43920","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 OS=Homo sapiens OX=9606 GN=NDUFS5 PE=1 SV=3","NDUFS5",1.241318482,0.014320585,"nochange",35524.3,39971.9,40091.3,45678.9,51046.8,46755.2,0.822739477,0.925745479,0.928510772,1.057919067,1.182239131,1.082846075,"extracellular","K03938","NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045271 respiratory chain complex I; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0050136 NADH dehydrogenase (quinone) activity;",null,null,"C","KOG4110","NADH:ubiquinone oxidoreductase"," NDUFS5/15kDa","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198"]
["O43924","Retinal rod rhodopsin-sensitive cGMP 3'","5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1","PDE6D",0.518694462,0.013866183,"nochange",5736.64,6766.5,5861.39,3537.52,2289.64,3698.42,1.234123494,1.455677299,1.260960964,0.761026758,0.492570305,0.795641179,"cytoplasm","K13758","PDE6D; retinal rod rhodopsin-sensitive cGMP 3'","5'-cyclic phosphodiesterase subunit delta","hsa00230 Purine metabolism; hsa01100 Metabolic pathways","GO:0003008 system process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007600 sensory perception; GO:0007601 visual perception; GO:0007602 phototransduction; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0016319 mushroom body development; GO:0023052 signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034260 negative regulation of GTPase activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0044092 negative regulation of molecular function; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050953 sensory perception of light stimulus; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0060322 head development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function;","GO:0001750 photoreceptor outer segment; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031253 cell projection membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0042622 photoreceptor outer segment membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0060170 ciliary membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0097730 non-motile cilium; GO:0097731 9+0 non-motile cilium; GO:0097733 photoreceptor cell cilium; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004112 cyclic-nucleotide phosphodiesterase activity; GO:0004114 3'","5'-cyclic-nucleotide phosphodiesterase activity; GO:0004857 enzyme inhibitor activity; GO:0005095 GTPase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008081 phosphoric diester hydrolase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0042578 phosphoric ester hydrolase activity; GO:0047555 3'","5'-cyclic-GMP phosphodiesterase activity; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;",null,null,"T","KOG4038","cGMP-phosphodiesterase"," delta subunit","WP4803 CILIOPATHIES;WP4656 JOUBERT SYNDROME;WP4222 PHOSPHODIESTERASES IN NEURONAL FUNCTION","http://www.wikipathways.org/instance/WP4803_r110008;http://www.wikipathways.org/instance/WP4656_r120396;http://www.wikipathways.org/instance/WP4222_r107160",null,"R-HSA-162582 Signal Transduction;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-5617833 Cilium Assembly;R-HSA-5620920 Cargo trafficking to the periciliary membrane;R-HSA-5624958 ARL13B-mediated ciliary trafficking of INPP5E;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-9648002 RAS processing","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620920;https://reactome.org/PathwayBrowser/#/R-HSA-5624958;https://reactome.org/PathwayBrowser/#/R-HSA-5673001;https://reactome.org/PathwayBrowser/#/R-HSA-5683057;https://reactome.org/PathwayBrowser/#/R-HSA-5684996;https://reactome.org/PathwayBrowser/#/R-HSA-9648002"]
["O43929","Origin recognition complex subunit 4 OS=Homo sapiens OX=9606 GN=ORC4 PE=1 SV=2","ORC4",0.725195498,0.002008627,"down",11790.5,12055.7,10744.9,7926.99,8455,8703.32,1.185443293,1.212107096,1.080316326,0.796997339,0.850084648,0.875051297,"nucleus","K02606","ORC4; origin recognition complex subunit 4","hsa04110 Cell cycle","GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006270 DNA replication initiation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007049 cell cycle; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0022402 cell cycle process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1903047 mitotic cell cycle process;","GO:0000228 nuclear chromosome; GO:0000808 origin recognition complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005664 nuclear origin of replication recognition complex; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003688 DNA replication origin binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0036094 small molecule binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF13191","PF13191 AAA ATPase domain","L","KOG2228","Origin recognition complex"," subunit 4","WP179 CELL CYCLE;WP466 DNA REPLICATION;WP45 G1 TO S CELL CYCLE CONTROL","http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP466_r117096;http://www.wikipathways.org/instance/WP45_r106424",null,"R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation;R-HSA-113510 E2F mediated regulation of DNA replication;R-HSA-1640170 Cell Cycle;R-HSA-176187 Activation of ATR in response to replication stress;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-68616 Assembly of the ORC complex at the origin of replication;R-HSA-68689 CDC6 association with the ORC:origin complex;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68949 Orc1 removal from chromatin;R-HSA-68962 Activation of the pre-replicative complex;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints","https://reactome.org/PathwayBrowser/#/R-HSA-113507;https://reactome.org/PathwayBrowser/#/R-HSA-113510;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-176187;https://reactome.org/PathwayBrowser/#/R-HSA-453279;https://reactome.org/PathwayBrowser/#/R-HSA-68616;https://reactome.org/PathwayBrowser/#/R-HSA-68689;https://reactome.org/PathwayBrowser/#/R-HSA-68867;https://reactome.org/PathwayBrowser/#/R-HSA-68949;https://reactome.org/PathwayBrowser/#/R-HSA-68962;https://reactome.org/PathwayBrowser/#/R-HSA-69002;https://reactome.org/PathwayBrowser/#/R-HSA-69052;https://reactome.org/PathwayBrowser/#/R-HSA-69206;https://reactome.org/PathwayBrowser/#/R-HSA-69239;https://reactome.org/PathwayBrowser/#/R-HSA-69242;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69306;https://reactome.org/PathwayBrowser/#/R-HSA-69481;https://reactome.org/PathwayBrowser/#/R-HSA-69620"]
["O43933","Peroxisomal ATPase PEX1 OS=Homo sapiens OX=9606 GN=PEX1 PE=1 SV=1","PEX1",0.3470255,0.010583468,"nochange",3374.44,5314.56,3791.25,1533.75,1353.56,"NA",1.097910143,1.729148935,1.233523734,0.499021966,0.440395222,"NA","nucleus","K13338","PEX1; peroxin-1","hsa04146 Peroxisome","GO:0000003 reproduction; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007017 microtubule-based process; GO:0007031 peroxisome organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007422 peripheral nervous system development; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015919 peroxisomal membrane transport; GO:0016043 cellular component organization; GO:0016558 protein import into peroxisome matrix; GO:0017038 protein import; GO:0019953 sexual reproduction; GO:0021782 glial cell development; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042063 gliogenesis; GO:0042886 amide transport; GO:0043574 peroxisomal transport; GO:0044703 multi-organism reproductive process; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048137 spermatocyte division; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051301 cell division; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0060151 peroxisome localization; GO:0060152 microtubule-based peroxisome localization; GO:0065002 intracellular protein transmembrane transport; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005829 cytosol; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031903 microbody membrane; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008022 protein C-terminus binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF09263; PF09262; PF00004; PF17862","PF09263 Peroxisome biogenesis factor 1"," N-terminal ; PF09262 Peroxisome biogenesis factor 1"," N-terminal ; PF00004 ATPase family associated with various cellular activities (AAA); PF17862 AAA+ lid domain","O","KOG0735","AAA+-type ATPase",{"$nulls":3},"R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","BILE ACID METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM"]
["O60216","Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2","RAD21",1.124421381,0.01506488,"nochange",30511.5,30904.8,30656.3,34237.8,36327.8,32962.8,0.935930798,0.947995153,0.940372493,1.050233895,1.114343996,1.011123665,"cytoplasm","K06670","SCC1; cohesin complex subunit SCC1","hsa04110 Cell cycle","GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007062 sister chromatid cohesion; GO:0007063 regulation of sister chromatid cohesion; GO:0007064 mitotic sister chromatid cohesion; GO:0007088 regulation of mitotic nuclear division; GO:0007127 meiosis I; GO:0007129 homologous chromosome pairing at meiosis; GO:0007130 synaptonemal complex assembly; GO:0007131 reciprocal meiotic recombination; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0010965 regulation of mitotic sister chromatid separation; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016322 neuron remodeling; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035825 homologous recombination; GO:0042551 neuron maturation; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045132 meiotic chromosome segregation; GO:0045143 homologous chromosome segregation; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045841 negative regulation of mitotic metaphase/anaphase transition; GO:0045876 positive regulation of sister chromatid cohesion; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051984 positive regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0060255 regulation of macromolecule metabolic process; GO:0061982 meiosis I cell cycle process; GO:0065007 biological regulation; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070193 synaptonemal complex organization; GO:0070727 cellular macromolecule localization; GO:0071168 protein localization to chromatin; GO:0071695 anatomical structure maturation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000795 synaptonemal complex; GO:0000798 nuclear cohesin complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005705 polytene chromosome interband; GO:0005721 pericentric heterochromatin; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0008278 cohesin complex; GO:0016363 nuclear matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:0099086 synaptonemal structure;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003684 damaged DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"D","KOG1213","Sister chromatid cohesion complex Cohesin"," subunit RAD21/SCC1","WP179 CELL CYCLE;WP5117 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME;WP3995 PRION DISEASE PATHWAY;WP4240 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASEANAPHASE TRANSITION;WP5118 SMC1SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME","http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP5117_r119395;http://www.wikipathways.org/instance/WP3995_r119304;http://www.wikipathways.org/instance/WP4240_r106495;http://www.wikipathways.org/instance/WP5118_r119397","Transcription factor","R-HSA-1221632 Meiotic synapsis;R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2468052 Establishment of Sister Chromatid Cohesion;R-HSA-2470946 Cohesin Loading onto Chromatin;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68884 Mitotic Telophase/Cytokinesis;R-HSA-68886 M Phase;R-HSA-69242 S Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9018519 Estrogen-dependent gene expression","https://reactome.org/PathwayBrowser/#/R-HSA-1221632;https://reactome.org/PathwayBrowser/#/R-HSA-1474165;https://reactome.org/PathwayBrowser/#/R-HSA-1500620;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2468052;https://reactome.org/PathwayBrowser/#/R-HSA-2470946;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108214;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68884;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69242;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9018519","E2F TARGETS;G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O60220","Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1","TIMM8A",1.147664981,0.053420902,"nochange",37345.4,42030.5,42850.1,49151.3,46457.8,44665.4,0.853607517,0.960695313,0.979428992,1.123456146,1.061890549,1.020921484,"extracellular","K17780",null,null,"GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0030001 metal ion transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034220 ion transmembrane transport; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0098655 cation transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005758 mitochondrial intermembrane space; GO:0016020 membrane; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005215 transporter activity; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0046873 metal ion transmembrane transporter activity;","PF02953","PF02953 Tim10/DDP family zinc finger","U","KOG3489","Mitochondrial import inner membrane translocase"," subunit TIM8",{"$nulls":3},"R-HSA-1268020 Mitochondrial protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1268020;https://reactome.org/PathwayBrowser/#/R-HSA-9609507"]
["O60229","Kalirin OS=Homo sapiens OX=9606 GN=KALRN PE=1 SV=3","KALRN",1.259533469,0.430072397,"nochange",2706.89,1370.47,1525.27,1704.01,3179.48,2173.21,1.282954153,0.649546224,0.722915036,0.80763042,1.506942311,1.030011857,"cytoplasm","K15048",null,null,"GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001505 regulation of neurotransmitter levels; GO:0001558 regulation of cell growth; GO:0001662 behavioral fear response; GO:0001667 ameboidal-type cell migration; GO:0001764 neuron migration; GO:0001956 positive regulation of neurotransmitter secretion; GO:0002009 morphogenesis of an epithelium; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002209 behavioral defense response; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006911 phagocytosis"," engulfment; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007215 glutamate receptor signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007266 Rho protein signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007412 axon target recognition; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007422 peripheral nervous system development; GO:0007444 imaginal disc development; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007528 neuromuscular junction development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007567 parturition; GO:0007589 body fluid secretion; GO:0007595 lactation; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007613 memory; GO:0007626 locomotory behavior; GO:0007635 chemosensory behavior; GO:0008045 motor neuron axon guidance; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008078 mesodermal cell migration; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008344 adult locomotory behavior; GO:0008361 regulation of cell size; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010324 membrane invagination; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010817 regulation of hormone levels; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014056 regulation of acetylcholine secretion"," neurotransmission; GO:0014057 positive regulation of acetylcholine secretion"," neurotransmission; GO:0014070 response to organic cyclic compound; GO:0014812 muscle cell migration; GO:0014909 smooth muscle cell migration; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016319 mushroom body development; GO:0016477 cell migration; GO:0016601 Rac protein signal transduction; GO:0018991 oviposition; GO:0019098 reproductive behavior; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030516 regulation of axon extension; GO:0030534 adult behavior; GO:0030539 male genitalia development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030879 mammary gland development; GO:0031175 neuron projection development; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031503 protein-containing complex localization; GO:0031532 actin cytoskeleton reorganization; GO:0032222 regulation of synaptic transmission"," cholinergic; GO:0032224 positive regulation of synaptic transmission"," cholinergic; GO:0032228 regulation of synaptic transmission"," GABAergic; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033002 muscle cell proliferation; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0033555 multicellular organismal response to stress; GO:0034613 cellular protein localization; GO:0035020 regulation of Rac protein signal transduction; GO:0035022 positive regulation of Rac protein signal transduction; GO:0035023 regulation of Rho protein signal transduction; GO:0035025 positive regulation of Rho protein signal transduction; GO:0035107 appendage morphogenesis; GO:0035112 genitalia morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035176 social behavior; GO:0035218 leg disc development; GO:0035235 ionotropic glutamate receptor signaling pathway; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035418 protein localization to synapse; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040007 growth; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040028 regulation of vulval development; GO:0042220 response to cocaine; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042596 fear response; GO:0042711 maternal behavior; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043277 apoptotic cell clearance; GO:0043279 response to alkaloid; GO:0043412 macromolecule modification; GO:0043547 positive regulation of GTPase activity; GO:0043652 engulfment of apoptotic cell; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045773 positive regulation of axon extension; GO:0045887 positive regulation of synaptic assembly at neuromuscular junction; GO:0045927 positive regulation of growth; GO:0046578 regulation of Ras protein signal transduction; GO:0046579 positive regulation of Ras protein signal transduction; GO:0046661 male sex differentiation; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0046888 negative regulation of hormone secretion; GO:0046903 secretion; GO:0046928 regulation of neurotransmitter secretion; GO:0046958 nonassociative learning; GO:0046959 habituation; GO:0048013 ephrin receptor signaling pathway; GO:0048148 behavioral response to cocaine; GO:0048167 regulation of synaptic plasticity; GO:0048168 regulation of neuronal synaptic plasticity; GO:0048265 response to pain; GO:0048266 behavioral response to pain; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048580 regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048659 smooth muscle cell proliferation; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048806 genitalia development; GO:0048808 male genitalia morphogenesis; GO:0048812 neuron projection morphogenesis; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050808 synapse organization; GO:0050877 nervous system process; GO:0050878 regulation of body fluid levels; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051057 positive regulation of small GTPase mediated signal transduction; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051588 regulation of neurotransmitter transport; GO:0051590 positive regulation of neurotransmitter transport; GO:0051641 cellular localization; GO:0051668 localization within membrane; GO:0051674 localization of cell; GO:0051703 biological process involved in intraspecies interaction between organisms; GO:0051716 cellular response to stimulus; GO:0051952 regulation of amine transport; GO:0051954 positive regulation of amine transport; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0051966 regulation of synaptic transmission"," glutamatergic; GO:0060123 regulation of growth hormone secretion; GO:0060125 negative regulation of growth hormone secretion; GO:0060137 maternal process involved in parturition; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060359 response to ammonium ion; GO:0060429 epithelium development; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0060746 parental behavior; GO:0060998 regulation of dendritic spine development; GO:0060999 positive regulation of dendritic spine development; GO:0061001 regulation of dendritic spine morphogenesis; GO:0061003 positive regulation of dendritic spine morphogenesis; GO:0061024 membrane organization; GO:0061062 regulation of nematode larval development; GO:0061366 behavioral response to chemical pain; GO:0061368 behavioral response to formalin induced pain; GO:0061387 regulation of extent of cell growth; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0071704 organic substance metabolic process; GO:0071772 response to BMP; GO:0071840 cellular component organization or biogenesis; GO:0072347 response to anesthetic; GO:0072657 protein localization to membrane; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090278 negative regulation of peptide hormone secretion; GO:0090598 male anatomical structure morphogenesis; GO:0097120 receptor localization to synapse; GO:0097485 neuron projection guidance; GO:0098657 import into cell; GO:0098885 modification of postsynaptic actin cytoskeleton; GO:0098989 NMDA selective glutamate receptor signaling pathway; GO:0099010 modification of postsynaptic structure; GO:0099024 plasma membrane invagination; GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels; GO:0099175 regulation of postsynapse organization; GO:0099177 regulation of trans-synaptic signaling; GO:0099563 modification of synaptic structure; GO:0099633 protein localization to postsynaptic specialization membrane; GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane; GO:0110053 regulation of actin filament organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900006 positive regulation of dendrite development; GO:1900271 regulation of long-term synaptic potentiation; GO:1900273 positive regulation of long-term synaptic potentiation; GO:1901564 organonitrogen compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1902473 regulation of protein localization to synapse; GO:1902474 positive regulation of protein localization to synapse; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903076 regulation of protein localization to plasma membrane; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903539 protein localization to postsynaptic membrane; GO:1904375 regulation of protein localization to cell periphery; GO:1904396 regulation of neuromuscular junction development; GO:1904398 positive regulation of neuromuscular junction development; GO:1905475 regulation of protein localization to membrane; GO:1990138 neuron projection extension; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2001023 regulation of response to drug; GO:2001025 positive regulation of response to drug;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0014069 postsynaptic density; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032279 asymmetric synapse; GO:0036194 muscle cell projection; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF13716; PF00435; PF00621; PF00169; PF07679; PF00041; PF00069","PF13716 Divergent CRAL/TRIO domain; PF00435 Spectrin repeat; PF00621 RhoGEF domain; PF00169 PH domain; PF07679 Immunoglobulin I-set domain; PF00041 Fibronectin type III domain; PF00069 Protein kinase domain","T","KOG4240","Multidomain protein"," contains SPEC repeats"," PH"," SH3"," and separate rac-specific and rho-specific guanine nucleotide exchange factor domains",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-193648 NRAGE signals death through JNK;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-194315 Signaling by Rho GTPases;R-HSA-204998 Cell death signalling via NRAGE"," NRIF and NADE;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-3928662 EPHB-mediated forward signaling;R-HSA-416476 G alpha (q) signalling events;R-HSA-416482 G alpha (12/13) signalling events;R-HSA-422475 Axon guidance;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-73887 Death Receptor Signalling;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013408 RHOG GTPase cycle;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-193648;https://reactome.org/PathwayBrowser/#/R-HSA-193704;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-204998;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-3928662;https://reactome.org/PathwayBrowser/#/R-HSA-416476;https://reactome.org/PathwayBrowser/#/R-HSA-416482;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5683057;https://reactome.org/PathwayBrowser/#/R-HSA-5687128;https://reactome.org/PathwayBrowser/#/R-HSA-73887;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013408;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["O60231","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2","DHX16",0.978041603,0.495676933,"nochange",32066.4,30255.1,32312,30707,32054.1,29794.4,1.027829627,0.969771728,1.035701884,0.984256554,1.027435373,0.955004835,"nucleus","K12813","DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [EC:3.6.4.13]","hsa03040 Spliceosome","GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007530 sex determination; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010172 embryonic body morphogenesis; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018992 germ-line sex determination; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0034641 cellular nitrogen compound metabolic process; GO:0040007 growth; GO:0040021 hermaphrodite germ-line sex determination; GO:0040022 feminization of hermaphroditic germ-line; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003724 RNA helicase activity; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008186 ATP-dependent activity"," acting on RNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF00270; PF00271; PF04408; PF07717","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain; PF04408 Helicase associated domain (HA2); PF07717 Oligonucleotide/oligosaccharide-binding (OB)-fold","A","KOG0923","mRNA splicing factor ATP-dependent RNA helicase","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","APICAL JUNCTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION"]
["O60232","Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1","ZNRD2",0.869068989,0.013202731,"nochange",62524.7,65677,65713.4,53730.5,55530.9,59264.2,1.035060908,1.087245445,1.087848026,0.88947792,0.91928252,0.981085182,"extracellular",{"$nulls":3},"GO:0000278 mitotic cell cycle; GO:0007049 cell cycle; GO:0009987 cellular process;",null,"GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;",null,null,"DV","KOG4537","Zn-ribbon-containing protein implicated in mitosis"]
["O60244","Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2","MED14",1.134565071,0.010434088,"nochange",9701.76,10360.8,9605.02,11069.4,11547.6,11042.8,0.91920051,0.981641748,0.910034806,1.048778585,1.094086002,1.046258348,"nucleus","K15156","MED14; mediator of RNA polymerase II transcription subunit 14","hsa04919 Thyroid hormone signaling pathway","GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0014070 response to organic cyclic compound; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019827 stem cell population maintenance; GO:0023052 signaling; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030521 androgen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048545 response to steroid hormone; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0016591 RNA polymerase II"," holoenzyme; GO:0016592 mediator complex; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0070847 core mediator complex; GO:0090575 RNA polymerase II transcription regulator complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0030374 nuclear receptor coactivator activity; GO:0038023 signaling receptor activity; GO:0042809 vitamin D receptor binding; GO:0051427 hormone receptor binding; GO:0060089 molecular transducer activity; GO:0140110 transcription regulator activity;",null,null,"K","KOG1875","Thyroid hormone receptor-associated coactivator complex component (TRAP170)","WP4197 IMMUNE RESPONSE TO TUBERCULOSIS;WP4482 VITAMIN D IN INFLAMMATORY DISEASES","http://www.wikipathways.org/instance/WP4197_r120647;http://www.wikipathways.org/instance/WP4482_r112969",null,"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-1989781 PPARA activates gene expression;R-HSA-212436 Generic Transcription Pathway;R-HSA-381340 Transcriptional regulation of white adipocyte differentiation;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-556833 Metabolism of lipids;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1989781;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-381340;https://reactome.org/PathwayBrowser/#/R-HSA-400206;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["O60256","Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1","PRPSAP2",0.907219877,0.08499359,"nochange",74060.6,71406.9,71554.2,63823.4,71102.3,61960.7,1.073580343,1.035112384,1.03724764,0.925182184,1.030696911,0.898180538,"cytoplasm",{"$nulls":3},"GO:0001501 skeletal system development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043086 negative regulation of catalytic activity; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050790 regulation of catalytic activity; GO:0060348 bone development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0002189 ribose phosphate diphosphokinase complex; GO:0032991 protein-containing complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0030234 enzyme regulator activity; GO:0042802 identical protein binding; GO:0098772 molecular function regulator;","PF13793; PF14572","PF13793 N-terminal domain of ribose phosphate pyrophosphokinase; PF14572 Phosphoribosyl synthetase-associated domain","EF","KOG1503","Phosphoribosylpyrophosphate synthetase-associated protein"]
["O60260","E3 ubiquitin-protein ligase parkin OS=Homo sapiens OX=9606 GN=PRKN PE=1 SV=2","PRKN",1.2625412,0.196687153,"nochange",3151.06,2941.56,3349.06,3160.03,3749.36,5011.12,0.885038472,0.826196191,0.940650748,0.887557877,1.053083041,1.407473672,"cytoplasm","nucleus","K04556","PARK2; parkin [EC:2.3.2.31]","hsa04137 Mitophagy - animal; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa04120 Ubiquitin mediated proteolysis; hsa04141 Protein processing in endoplasmic reticulum; hsa05012 Parkinson disease","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000209 protein polyubiquitination; GO:0000266 mitochondrial fission; GO:0000422 autophagy of mitochondrion; GO:0000423 mitophagy; GO:0001101 response to acid chemical; GO:0001504 neurotransmitter uptake; GO:0001505 regulation of neurotransmitter levels; GO:0001558 regulation of cell growth; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001961 positive regulation of cytokine-mediated signaling pathway; GO:0001963 synaptic transmission"," dopaminergic; GO:0001964 startle response; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006109 regulation of carbohydrate metabolic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006513 protein monoubiquitination; GO:0006584 catecholamine metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006836 neurotransmitter transport; GO:0006839 mitochondrial transport; GO:0006914 autophagy; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007568 aging; GO:0007584 response to nutrient; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007626 locomotory behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008340 determination of adult lifespan; GO:0008344 adult locomotory behavior; GO:0008345 larval locomotory behavior; GO:0008637 apoptotic mitochondrial changes; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009605 response to external stimulus; GO:0009636 response to toxic substance; GO:0009712 catechol-containing compound metabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010042 response to manganese ion; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010635 regulation of mitochondrial fusion; GO:0010636 positive regulation of mitochondrial fusion; GO:0010637 negative regulation of mitochondrial fusion; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010677 negative regulation of cellular carbohydrate metabolic process; GO:0010720 positive regulation of cell development; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010817 regulation of hormone levels; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010906 regulation of glucose metabolic process; GO:0010918 positive regulation of mitochondrial membrane potential; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0010992 ubiquitin recycling; GO:0010994 free ubiquitin chain polymerization; GO:0012501 programmed cell death; GO:0014059 regulation of dopamine secretion; GO:0014070 response to organic cyclic compound; GO:0014823 response to activity; GO:0014850 response to muscle activity; GO:0015844 monoamine transport; GO:0015850 organic hydroxy compound transport; GO:0015872 dopamine transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016236 macroautophagy; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016567 protein ubiquitination; GO:0016579 protein deubiquitination; GO:0017157 regulation of exocytosis; GO:0018958 phenol-containing compound metabolic process; GO:0019048 modulation by virus of host process; GO:0019054 modulation by virus of host cellular process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030100 regulation of endocytosis; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030307 positive regulation of cell growth; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030382 sperm mitochondrion organization; GO:0030534 adult behavior; GO:0030537 larval behavior; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030810 positive regulation of nucleotide biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031644 regulation of nervous system process; GO:0031645 negative regulation of nervous system process; GO:0031647 regulation of protein stability; GO:0031648 protein destabilization; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0031670 cellular response to nutrient; GO:0031960 response to corticosteroid; GO:0032024 positive regulation of insulin secretion; GO:0032092 positive regulation of protein binding; GO:0032231 regulation of actin filament bundle assembly; GO:0032232 negative regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032368 regulation of lipid transport; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033131 regulation of glucokinase activity; GO:0033132 negative regulation of glucokinase activity; GO:0033157 regulation of intracellular protein transport; GO:0033238 regulation of cellular amine metabolic process; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033673 negative regulation of kinase activity; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0034620 cellular response to unfolded protein; GO:0034976 response to endoplasmic reticulum stress; GO:0035249 synaptic transmission"," glutamatergic; GO:0035519 protein K29-linked ubiquitination; GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0035821 modulation of process of another organism; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0040008 regulation of growth; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042053 regulation of dopamine metabolic process; GO:0042069 regulation of catecholamine metabolic process; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042391 regulation of membrane potential; GO:0042415 norepinephrine metabolic process; GO:0042417 dopamine metabolic process; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043200 response to amino acid; GO:0043269 regulation of ion transport; GO:0043388 positive regulation of DNA binding; GO:0043393 regulation of protein binding; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043549 regulation of kinase activity; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043653 mitochondrial fragmentation involved in apoptotic process; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044003 modulation by symbiont of host process; GO:0044057 regulation of system process; GO:0044068 modulation by symbiont of host cellular process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044314 protein K27-linked ubiquitination; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0044788 modulation by host of viral process; GO:0044793 negative regulation by host of viral process; GO:0044827 modulation by host of viral genome replication; GO:0044828 negative regulation by host of viral genome replication; GO:0045069 regulation of viral genome replication; GO:0045071 negative regulation of viral genome replication; GO:0045472 response to ether; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045732 positive regulation of protein catabolic process; GO:0045806 negative regulation of endocytosis; GO:0045838 positive regulation of membrane potential; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045912 negative regulation of carbohydrate metabolic process; GO:0045920 negative regulation of exocytosis; GO:0045927 positive regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045981 positive regulation of nucleotide metabolic process; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046676 negative regulation of insulin secretion; GO:0046677 response to antibiotic; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0046888 negative regulation of hormone secretion; GO:0046928 regulation of neurotransmitter secretion; GO:0046929 negative regulation of neurotransmitter secretion; GO:0048070 regulation of developmental pigmentation; GO:0048073 regulation of eye pigmentation; GO:0048075 positive regulation of eye pigmentation; GO:0048076 regulation of compound eye pigmentation; GO:0048078 positive regulation of compound eye pigmentation; GO:0048087 positive regulation of developmental pigmentation; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050433 regulation of catecholamine secretion; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050764 regulation of phagocytosis; GO:0050765 negative regulation of phagocytosis; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050801 ion homeostasis; GO:0050804 modulation of chemical synaptic transmission; GO:0050805 negative regulation of synaptic transmission; GO:0050821 protein stabilization; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051258 protein polymerization; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051341 regulation of oxidoreductase activity; GO:0051348 negative regulation of transferase activity; GO:0051354 negative regulation of oxidoreductase activity; GO:0051384 response to glucocorticoid; GO:0051385 response to mineralocorticoid; GO:0051412 response to corticosterone; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051580 regulation of neurotransmitter uptake; GO:0051582 positive regulation of neurotransmitter uptake; GO:0051583 dopamine uptake involved in synaptic transmission; GO:0051588 regulation of neurotransmitter transport; GO:0051589 negative regulation of neurotransmitter transport; GO:0051590 positive regulation of neurotransmitter transport; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051649 establishment of localization in cell; GO:0051701 biological process involved in interaction with host; GO:0051702 biological process involved in interaction with symbiont; GO:0051716 cellular response to stimulus; GO:0051851 modulation by host of symbiont process; GO:0051865 protein autoubiquitination; GO:0051881 regulation of mitochondrial membrane potential; GO:0051934 catecholamine uptake involved in synaptic transmission; GO:0051937 catecholamine transport; GO:0051952 regulation of amine transport; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051966 regulation of synaptic transmission"," glutamatergic; GO:0051967 negative regulation of synaptic transmission"," glutamatergic; GO:0055065 metal ion homeostasis; GO:0055069 zinc ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060101 negative regulation of phagocytosis"," engulfment; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060359 response to ammonium ion; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0060759 regulation of response to cytokine stimulus; GO:0060760 positive regulation of response to cytokine stimulus; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0061726 mitochondrion disassembly; GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; GO:0061912 selective autophagy; GO:0061919 process utilizing autophagic mechanism; GO:0062012 regulation of small molecule metabolic process; GO:0062013 positive regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070050 neuron cellular homeostasis; GO:0070201 regulation of establishment of protein localization; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0070534 protein K63-linked ubiquitination; GO:0070585 protein localization to mitochondrion; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0070841 inclusion body assembly; GO:0070842 aggresome assembly; GO:0070887 cellular response to chemical stimulus; GO:0070936 protein K48-linked ubiquitination; GO:0070979 protein K11-linked ubiquitination; GO:0071229 cellular response to acid chemical; GO:0071230 cellular response to amino acid stimulus; GO:0071241 cellular response to inorganic substance; GO:0071242 cellular response to ammonium ion; GO:0071248 cellular response to metal ion; GO:0071287 cellular response to manganese ion; GO:0071310 cellular response to organic substance; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0071867 response to monoamine; GO:0071868 cellular response to monoamine stimulus; GO:0071869 response to catecholamine; GO:0071870 cellular response to catecholamine stimulus; GO:0072507 divalent inorganic cation homeostasis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0085020 protein K6-linked ubiquitination; GO:0090087 regulation of peptide transport; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090140 regulation of mitochondrial fission; GO:0090141 positive regulation of mitochondrial fission; GO:0090199 regulation of release of cytochrome c from mitochondria; GO:0090201 negative regulation of release of cytochrome c from mitochondria; GO:0090258 negative regulation of mitochondrial fission; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:0090278 negative regulation of peptide hormone secretion; GO:0090394 negative regulation of excitatory postsynaptic potential; GO:0090493 catecholamine uptake; GO:0090494 dopamine uptake; GO:0097164 ammonium ion metabolic process; GO:0097237 cellular response to toxic substance; GO:0097305 response to alcohol; GO:0097327 response to antineoplastic agent; GO:0098657 import into cell; GO:0098771 inorganic ion homeostasis; GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization; GO:0098780 response to mitochondrial depolarisation; GO:0098810 neurotransmitter reuptake; GO:0098815 modulation of excitatory postsynaptic potential; GO:0098916 anterograde trans-synaptic signaling; GO:0099074 mitochondrion to lysosome transport; GO:0099075 mitochondrion-derived vesicle mediated transport; GO:0099177 regulation of trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0110053 regulation of actin filament organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0150003 regulation of spontaneous synaptic transmission; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900373 positive regulation of purine nucleotide biosynthetic process; GO:1900407 regulation of cellular response to oxidative stress; GO:1900408 negative regulation of cellular response to oxidative stress; GO:1900542 regulation of purine nucleotide metabolic process; GO:1900544 positive regulation of purine nucleotide metabolic process; GO:1901074 regulation of engulfment of apoptotic cell; GO:1901075 negative regulation of engulfment of apoptotic cell; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901524 regulation of mitophagy; GO:1901526 positive regulation of mitophagy; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901654 response to ketone; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901797 negative regulation of signal transduction by p53 class mediator; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1902065 response to L-glutamate; GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902283 negative regulation of primary amine oxidase activity; GO:1902528 regulation of protein linear polyubiquitination; GO:1902530 positive regulation of protein linear polyubiquitination; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902803 regulation of synaptic vesicle transport; GO:1902882 regulation of response to oxidative stress; GO:1902883 negative regulation of response to oxidative stress; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1902914 regulation of protein polyubiquitination; GO:1902916 positive regulation of protein polyubiquitination; GO:1903008 organelle disassembly; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903146 regulation of autophagy of mitochondrion; GO:1903201 regulation of oxidative stress-induced cell death; GO:1903202 negative regulation of oxidative stress-induced cell death; GO:1903203 regulation of oxidative stress-induced neuron death; GO:1903204 negative regulation of oxidative stress-induced neuron death; GO:1903214 regulation of protein targeting to mitochondrion; GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway; GO:1903299 regulation of hexokinase activity; GO:1903300 negative regulation of hexokinase activity; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903350 response to dopamine; GO:1903351 cellular response to dopamine; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; GO:1903381 regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; GO:1903426 regulation of reactive oxygen species biosynthetic process; GO:1903427 negative regulation of reactive oxygen species biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903533 regulation of protein targeting; GO:1903541 regulation of exosomal secretion; GO:1903542 negative regulation of exosomal secretion; GO:1903573 negative regulation of response to endoplasmic reticulum stress; GO:1903578 regulation of ATP metabolic process; GO:1903580 positive regulatio","GO:0000139 Golgi membrane; GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0016234 inclusion body; GO:0016235 aggresome; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0019867 outer membrane; GO:0030133 transport vesicle; GO:0030424 axon; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030672 synaptic vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032279 asymmetric synapse; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0045121 membrane raft; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0070382 exocytic vesicle; GO:0097413 Lewy body; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0098827 endoplasmic reticulum subcompartment; GO:0098857 membrane microdomain; GO:0098984 neuron to neuron synapse; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1902494 catalytic complex; GO:1990234 transferase complex; GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex;","GO:0000976 transcription cis-regulatory region binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001664 G protein-coupled receptor binding; GO:0002020 protease binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008092 cytoskeletal protein binding; GO:0008270 zinc ion binding; GO:0015631 tubulin binding; GO:0016740 transferase activity; GO:0017124 SH3 domain binding; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030165 PDZ domain binding; GO:0030544 Hsp70 protein binding; GO:0031072 heat shock protein binding; GO:0031624 ubiquitin conjugating enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0032182 ubiquitin-like protein binding; GO:0042802 identical protein binding; GO:0042826 histone deacetylase binding; GO:0043130 ubiquitin binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043274 phospholipase binding; GO:0043565 sequence-specific DNA binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044390 ubiquitin-like protein conjugating enzyme binding; GO:0044877 protein-containing complex binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051087 chaperone binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0097159 organic cyclic compound binding; GO:0097602 cullin family protein binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990381 ubiquitin-specific protease binding; GO:1990444 F-box domain binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00240; PF17976; PF17978","PF00240 Ubiquitin family; PF17976 RING/Ubox like zinc-binding domain; PF17978 RING/Ubox like zinc-binding domain","O","KOG0006","E3 ubiquitin-protein ligase (Parkin protein)","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME;WP2371 PARKINSONS DISEASE PATHWAY;WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY","http://www.wikipathways.org/instance/WP4657_r120007;http://www.wikipathways.org/instance/WP2371_r119919;http://www.wikipathways.org/instance/WP2359_r119918",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-1632852 Macroautophagy;R-HSA-168256 Immune System;R-HSA-392499 Metabolism of proteins;R-HSA-5205647 Mitophagy;R-HSA-5205685 PINK1-PRKN Mediated Mitophagy;R-HSA-5688426 Deubiquitination;R-HSA-5689877 Josephin domain DUBs;R-HSA-597592 Post-translational protein modification;R-HSA-9612973 Autophagy;R-HSA-9646399 Aggrephagy;R-HSA-9663891 Selective autophagy;R-HSA-977225 Amyloid fiber formation;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5205647;https://reactome.org/PathwayBrowser/#/R-HSA-5205685;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689877;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9646399;https://reactome.org/PathwayBrowser/#/R-HSA-9663891;https://reactome.org/PathwayBrowser/#/R-HSA-977225;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169","KRAS SIGNALING DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_DN"]
["O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1","SMARCA5",1.02968673,0.214579756,"nochange",88421.8,86845.6,86701.5,93072.7,89333.7,87339.5,0.997773242,0.979987016,0.978360956,1.050255137,1.008063345,0.985560304,"cytoplasm","nucleus","K11654",null,null,"GO:0000003 reproduction; GO:0000183 rDNA heterochromatin assembly; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006334 nucleosome assembly; GO:0006336 DNA replication-independent chromatin assembly; GO:0006338 chromatin remodeling; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007289 spermatid nucleus differentiation; GO:0007338 single fertilization; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009566 fertilization; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016584 nucleosome positioning; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0030575 nuclear body organization; GO:0031055 chromatin remodeling at centromere; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031497 chromatin assembly; GO:0032392 DNA geometric change; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032508 DNA duplex unwinding; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0033993 response to lipid; GO:0034080 CENP-A containing chromatin assembly; GO:0034097 response to cytokine; GO:0034508 centromere complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034724 DNA replication-independent chromatin organization; GO:0034728 nucleosome organization; GO:0035039 male pronucleus assembly; GO:0035041 sperm DNA decondensation; GO:0035063 nuclear speck organization; GO:0035075 response to ecdysone; GO:0035076 ecdysone receptor-mediated signaling pathway; GO:0035092 sperm DNA condensation; GO:0036314 response to sterol; GO:0036315 cellular response to sterol; GO:0040026 positive regulation of vulval development; GO:0040028 regulation of vulval development; GO:0040029 regulation of gene expression"," epigenetic; GO:0042221 response to chemical; GO:0042752 regulation of circadian rhythm; GO:0042766 nucleosome mobilization; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043486 histone exchange; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048580 regulation of post-embryonic development; GO:0048582 positive regulation of post-embryonic development; GO:0048609 multicellular organismal reproductive process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0061062 regulation of nematode larval development; GO:0061063 positive regulation of nematode larval development; GO:0061641 CENP-A containing chromatin organization; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071103 DNA conformation change; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071383 cellular response to steroid hormone stimulus; GO:0071390 cellular response to ecdysone; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000793 condensed chromosome; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005677 chromatin silencing complex; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005730 nucleolus; GO:0008623 CHRAC; GO:0016589 NURF complex; GO:0016590 ACF complex; GO:0017053 transcription repressor complex; GO:0031010 ISWI-type complex; GO:0031213 RSF complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0090537 CERF complex; GO:1902494 catalytic complex; GO:1904949 ATPase complex;","GO:0000166 nucleotide binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003700 DNA-binding transcription factor activity; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0008134 transcription factor binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0036310 ATP-dependent DNA/DNA annealing activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140097 catalytic activity"," acting on DNA; GO:0140110 transcription regulator activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00176; PF00271; PF09110; PF09111","PF00176 SNF2-related domain; PF00271 Helicase conserved C-terminal domain; PF09110 HAND; PF09111 SLIDE","K","KOG0385","Chromatin remodeling complex WSTF-ISWI"," small subunit","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4932_r118797","Transcription factor","R-HSA-1640170 Cell Cycle;R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-5250913 Positive epigenetic regulation of rRNA expression;R-HSA-5250924 B-WICH complex positively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;R-HSA-5693606 DNA Double Strand Break Response;R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere;R-HSA-73886 Chromosome Maintenance;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-774815 Nucleosome assembly","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-427413;https://reactome.org/PathwayBrowser/#/R-HSA-5250913;https://reactome.org/PathwayBrowser/#/R-HSA-5250924;https://reactome.org/PathwayBrowser/#/R-HSA-5250941;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693565;https://reactome.org/PathwayBrowser/#/R-HSA-5693606;https://reactome.org/PathwayBrowser/#/R-HSA-606279;https://reactome.org/PathwayBrowser/#/R-HSA-73886;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-774815"]
["O60271","C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4","SPAG9",1.099993105,0.079150115,"nochange",16666.9,14728,16467.4,17136.4,17867.4,17644.4,0.994934858,0.879191726,0.983025654,1.02296178,1.066599012,1.05328697,"endoplasmic reticulum","K20317",null,null,"GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007588 excretion; GO:0007610 behavior; GO:0008088 axo-dendritic transport; GO:0008152 metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016310 phosphorylation; GO:0016482 cytosolic transport; GO:0018991 oviposition; GO:0019098 reproductive behavior; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030421 defecation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032091 negative regulation of protein binding; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042692 muscle cell differentiation; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043496 regulation of protein homodimerization activity; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046907 intracellular transport; GO:0048489 synaptic vesicle transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051146 striated muscle cell differentiation; GO:0051147 regulation of muscle cell differentiation; GO:0051149 positive regulation of muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0061061 muscle structure development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090074 negative regulation of protein homodimerization activity; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0099003 vesicle-mediated transport in synapse; GO:0099111 microtubule-based transport; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0000139 Golgi membrane; GO:0001669 acrosomal vesicle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030140 trans-Golgi network transport vesicle; GO:0030141 secretory granule; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043194 axon initial segment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044304 main axon; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005078 MAP-kinase scaffold activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008432 JUN kinase binding; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030159 signaling receptor complex adaptor activity; GO:0035591 signaling adaptor activity; GO:0048273 mitogen-activated protein kinase p38 binding; GO:0051019 mitogen-activated protein kinase binding; GO:0060090 molecular adaptor activity;",null,null,"T","KOG2077","JNK/SAPK-associated protein-1",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-525793 Myogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-525793"]
["O60281","Zinc finger protein 292 OS=Homo sapiens OX=9606 GN=ZNF292 PE=1 SV=3","ZNF292",0.911620599,0.237574629,"nochange",3526.69,3908.25,3212.79,3074.71,3433.1,3198.88,1.039584523,1.152059356,0.947054252,0.906351544,1.011996412,0.942953914,"nucleus",{"$nulls":3},"GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor",null,null,"GLYCOLYSIS;HYPOXIA","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA"]
["O60293","Zinc finger C3H1 domain-containing protein OS=Homo sapiens OX=9606 GN=ZFC3H1 PE=1 SV=3","ZFC3H1",0.658013951,0.000942093,"down",10083.4,9663.93,9145.72,5956.15,6800.99,6254.89,1.262922429,1.210384786,1.145480187,0.745993953,0.851808201,0.783410444,"nucleus",{"$nulls":4},"GO:0000178 exosome (RNase complex); GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1902494 catalytic complex; GO:1905354 exoribonuclease complex;",null,"PF10650","PF10650 Putative zinc-finger domain","S","KOG4839","Uncharacterized conserved protein"]
["O60294","tRNA wybutosine-synthesizing protein 4 OS=Homo sapiens OX=9606 GN=LCMT2 PE=1 SV=3","LCMT2",0.990235321,0.886706867,"nochange",3873.76,2589.62,1648.51,3024.65,2819.74,2188.29,1.439651846,0.96241151,0.612655524,1.124086922,1.047933763,0.813260434,"nucleus","K15451",null,null,"GO:0001510 RNA methylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006400 tRNA modification; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006481 C-terminal protein methylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0009058 biosynthetic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0018410 C-terminal protein amino acid modification; GO:0019538 protein metabolic process; GO:0030488 tRNA methylation; GO:0031590 wybutosine metabolic process; GO:0031591 wybutosine biosynthetic process; GO:0032259 methylation; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901657 glycosyl compound metabolic process; GO:1901659 glycosyl compound biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0003880 protein C-terminal carboxyl O-methyltransferase activity; GO:0008168 methyltransferase activity; GO:0008171 O-methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008175 tRNA methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0010340 carboxyl-O-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0051998 protein carboxyl O-methyltransferase activity; GO:0140096 catalytic activity"," acting on a protein; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;",null,null,"O","KOG2918","Carboxymethyl transferase",{"$nulls":3},"R-HSA-6782315 tRNA modification in the nucleus and cytosol;R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe);R-HSA-72306 tRNA processing;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6782315;https://reactome.org/PathwayBrowser/#/R-HSA-6782861;https://reactome.org/PathwayBrowser/#/R-HSA-72306;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O60306","RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4","AQR",1.167123671,0.000614837,"up",24485.1,24358.3,23985.9,28550.6,28909.4,27540.8,0.930814845,0.925994471,0.911837476,1.085367113,1.099007097,1.046978998,"cytoplasm","K12874","AQR; intron-binding protein aquarius","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0000974 Prp19 complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071007 U2-type catalytic step 2 spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF13086; PF13087","PF13086 AAA domain; PF13087 AAA domain","L","KOG1806","DEAD box containing helicases",{"$nulls":3},"R-HSA-5696398 Nucleotide Excision Repair;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73894 DNA Repair;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-6781823;https://reactome.org/PathwayBrowser/#/R-HSA-6781827;https://reactome.org/PathwayBrowser/#/R-HSA-6782135;https://reactome.org/PathwayBrowser/#/R-HSA-6782210;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O60313","Dynamin-like 120 kDa protein"," mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3","OPA1",0.934613591,0.134222499,"nochange",19189.6,20280.9,18215.8,17381.9,18474.1,18058.4,1.031692454,1.090364129,0.979337943,0.934504891,0.993224953,0.970875631,"mitochondria","K17079","OPA1; optic atrophy protein 1 [EC:3.6.5.5]","hsa05017 Spinocerebellar ataxia","GO:0000002 mitochondrial genome maintenance; GO:0000266 mitochondrial fission; GO:0000302 response to reactive oxygen species; GO:0000303 response to superoxide; GO:0000305 response to oxygen radical; GO:0001101 response to acid chemical; GO:0001654 eye development; GO:0001666 response to hypoxia; GO:0001678 cellular glucose homeostasis; GO:0001745 compound eye morphogenesis; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0002009 morphogenesis of an epithelium; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003008 system process; GO:0003373 dynamin family protein polymerization involved in membrane fission; GO:0003374 dynamin family protein polymerization involved in mitochondrial fission; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006839 mitochondrial transport; GO:0006851 mitochondrial calcium ion transmembrane transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007007 inner mitochondrial membrane organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007507 heart development; GO:0007568 aging; GO:0007569 cell aging; GO:0007584 response to nutrient; GO:0007600 sensory perception; GO:0007601 visual perception; GO:0008053 mitochondrial fusion; GO:0008088 axo-dendritic transport; GO:0008152 metabolic process; GO:0009116 nucleoside metabolic process; GO:0009117 nucleotide metabolic process; GO:0009119 ribonucleoside metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010243 response to organonitrogen compound; GO:0010635 regulation of mitochondrial fusion; GO:0010636 positive regulation of mitochondrial fusion; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010941 regulation of cell death; GO:0010970 transport along microtubule; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014020 primary neural tube formation; GO:0014041 regulation of neuron maturation; GO:0014042 positive regulation of neuron maturation; GO:0014070 response to organic cyclic compound; GO:0014706 striated muscle tissue development; GO:0014823 response to activity; GO:0014850 response to muscle activity; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019725 cellular homeostasis; GO:0019896 axonal transport of mitochondrion; GO:0021915 neural tube development; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030001 metal ion transport; GO:0030154 cell differentiation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0031670 cellular response to nutrient; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0034220 ion transmembrane transport; GO:0034284 response to monosaccharide; GO:0034641 cellular nitrogen compound metabolic process; GO:0034643 establishment of mitochondrion localization"," microtubule-mediated; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0035051 cardiocyte differentiation; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035264 multicellular organism growth; GO:0035295 tube development; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0036444 calcium import into the mitochondrion; GO:0040007 growth; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0042221 response to chemical; GO:0042278 purine nucleoside metabolic process; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042692 muscle cell differentiation; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043010 camera-type eye development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043200 response to amino acid; GO:0043583 ear development; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045472 response to ether; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046039 GTP metabolic process; GO:0046128 purine ribonucleoside metabolic process; GO:0046324 regulation of glucose import; GO:0046326 positive regulation of glucose import; GO:0046483 heterocycle metabolic process; GO:0046677 response to antibiotic; GO:0046907 intracellular transport; GO:0047497 mitochondrion transport along microtubule; GO:0048284 organelle fusion; GO:0048285 organelle fission; GO:0048311 mitochondrion distribution; GO:0048312 intracellular distribution of mitochondria; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048589 developmental growth; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048638 regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048749 compound eye development; GO:0048814 regulation of dendrite morphogenesis; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050953 sensory perception of light stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051258 protein polymerization; GO:0051259 protein complex oligomerization; GO:0051602 response to electrical stimulus; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051649 establishment of localization in cell; GO:0051654 establishment of mitochondrion localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0055006 cardiac cell development; GO:0055007 cardiac muscle cell differentiation; GO:0055012 ventricular cardiac muscle cell differentiation; GO:0055013 cardiac muscle cell development; GO:0055015 ventricular cardiac muscle cell development; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060041 retina development in camera-type eye; GO:0060284 regulation of cell development; GO:0060401 cytosolic calcium ion transport; GO:0060429 epithelium development; GO:0060537 muscle tissue development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0060998 regulation of dendritic spine development; GO:0060999 positive regulation of dendritic spine development; GO:0061001 regulation of dendritic spine morphogenesis; GO:0061003 positive regulation of dendritic spine morphogenesis; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0061061 muscle structure development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070482 response to oxygen levels; GO:0070509 calcium ion import; GO:0070584 mitochondrion morphogenesis; GO:0070588 calcium ion transmembrane transport; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071230 cellular response to amino acid stimulus; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071326 cellular response to monosaccharide stimulus; GO:0071331 cellular response to hexose stimulus; GO:0071333 cellular response to glucose stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0072384 organelle transport along microtubule; GO:0072521 purine-containing compound metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090102 cochlea development; GO:0090148 membrane fission; GO:0090199 regulation of release of cytochrome c from mitochondria; GO:0090201 negative regulation of release of cytochrome c from mitochondria; GO:0090398 cellular senescence; GO:0090596 sensory organ morphogenesis; GO:0097327 response to antineoplastic agent; GO:0097749 membrane tubulation; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098930 axonal transport; GO:0099111 microtubule-based transport; GO:0099175 regulation of postsynapse organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900078 positive regulation of cellular response to insulin stimulus; GO:1901068 guanosine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901654 response to ketone; GO:1901657 glycosyl compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902065 response to L-glutamate; GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903429 regulation of cell maturation; GO:1903431 positive regulation of cell maturation; GO:1903573 negative regulation of response to endoplasmic reticulum stress; GO:1904643 response to curcumin; GO:1905232 cellular response to L-glutamate; GO:1905897 regulation of response to endoplasmic reticulum stress; GO:1990542 mitochondrial transmembrane transport; GO:2000026 regulation of multicellular organismal development; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005743 mitochondrial inner membrane; GO:0005758 mitochondrial intermembrane space; GO:0005829 cytosol; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0019867 outer membrane; GO:0019898 extrinsic component of membrane; GO:0030061 mitochondrial crista; GO:0030425 dendrite; GO:0031090 organelle membrane; GO:0031312 extrinsic component of organelle membrane; GO:0031314 extrinsic component of mitochondrial inner membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097447 dendritic tree; GO:0098588 bounding membrane of organelle; GO:0120025 plasma membrane bounded cell projection;","GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0015631 tubulin binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017111 nucleoside-triphosphatase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0070300 phosphatidic acid binding; GO:1901611 phosphatidylglycerol binding; GO:1901612 cardiolipin binding;","PF00350; PF19434","PF00350 Dynamin family; PF19434 Dynamin-like GTPase OPA1 C-terminal","R","KOG0447","Dynamin-like GTP binding protein","WP5094 OREXIN RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP5094_r120665",null,"R-HSA-109581 Apoptosis;R-HSA-169911 Regulation of Apoptosis;R-HSA-5357801 Programmed Cell Death","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-169911;https://reactome.org/PathwayBrowser/#/R-HSA-5357801","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O60315","Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1","ZEB2",1.192717718,0.048788444,"nochange",8316.08,7047.51,8572.04,9891.22,9253.61,9403.62,0.950697431,0.805674025,0.979958875,1.130768035,1.057876217,1.075025417,"nucleus","K23560","ZEB2; zinc finger homeobox protein 2","hsa05206 MicroRNAs in cancer","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001558 regulation of cell growth; GO:0001655 urogenital system development; GO:0001667 ameboidal-type cell migration; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001755 neural crest cell migration; GO:0001756 somitogenesis; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007280 pole cell migration; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007498 mesoderm development; GO:0007507 heart development; GO:0007516 hemocyte development; GO:0007548 sex differentiation; GO:0008045 motor neuron axon guidance; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008354 germ cell migration; GO:0008361 regulation of cell size; GO:0008406 gonad development; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014020 primary neural tube formation; GO:0014031 mesenchymal cell development; GO:0014032 neural crest cell development; GO:0014033 neural crest cell differentiation; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016070 RNA metabolic process; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0017145 stem cell division; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019730 antimicrobial humoral response; GO:0019953 sexual reproduction; GO:0021536 diencephalon development; GO:0021537 telencephalon development; GO:0021540 corpus callosum morphogenesis; GO:0021543 pallium development; GO:0021761 limbic system development; GO:0021766 hippocampus development; GO:0021767 mammillary body development; GO:0021846 cell proliferation in forebrain; GO:0021915 neural tube development; GO:0021952 central nervous system projection neuron axonogenesis; GO:0021953 central nervous system neuron differentiation; GO:0021954 central nervous system neuron development; GO:0021955 central nervous system neuron axonogenesis; GO:0021957 corticospinal tract morphogenesis; GO:0022008 neurogenesis; GO:0022038 corpus callosum development; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030516 regulation of axon extension; GO:0030856 regulation of epithelial cell differentiation; GO:0030857 negative regulation of epithelial cell differentiation; GO:0030858 positive regulation of epithelial cell differentiation; GO:0030900 forebrain development; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032774 RNA biosynthetic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033674 positive regulation of kinase activity; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035295 tube development; GO:0040007 growth; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042386 hemocyte differentiation; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043455 regulation of secondary metabolic process; GO:0043473 pigmentation; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043549 regulation of kinase activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045137 development of primary sexual characteristics; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045601 regulation of endothelial cell differentiation; GO:0045602 negative regulation of endothelial cell differentiation; GO:0045634 regulation of melanocyte differentiation; GO:0045636 positive regulation of melanocyte differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045773 positive regulation of axon extension; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046483 heterocycle metabolic process; GO:0048021 regulation of melanin biosynthetic process; GO:0048023 positive regulation of melanin biosynthetic process; GO:0048066 developmental pigmentation; GO:0048070 regulation of developmental pigmentation; GO:0048087 positive regulation of developmental pigmentation; GO:0048103 somatic stem cell division; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048542 lymph gland development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048668 collateral sprouting; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048762 mesenchymal cell differentiation; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048863 stem cell differentiation; GO:0048864 stem cell development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0050932 regulation of pigment cell differentiation; GO:0050942 positive regulation of pigment cell differentiation; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051301 cell division; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060429 epithelium development; GO:0060485 mesenchyme development; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0061053 somite development; GO:0061318 renal filtration cell differentiation; GO:0061319 nephrocyte differentiation; GO:0061321 garland nephrocyte differentiation; GO:0061351 neural precursor cell proliferation; GO:0061373 mammillary axonal complex development; GO:0061387 regulation of extent of cell growth; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072001 renal system development; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090304 nucleic acid metabolic process; GO:0097324 melanocyte migration; GO:0097485 neuron projection guidance; GO:0097659 nucleic acid-templated transcription; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900376 regulation of secondary metabolite biosynthetic process; GO:1900378 positive regulation of secondary metabolite biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902746 regulation of lens fiber cell differentiation; GO:1902748 positive regulation of lens fiber cell differentiation; GO:1903056 regulation of melanosome organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0019208 phosphatase regulator activity; GO:0030234 enzyme regulator activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046332 SMAD binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0070412 R-SMAD binding; GO:0070888 E-box binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF05605; PF00096; PF12874","PF05605 Drought induced 19 protein (Di19)"," zinc-binding; PF00096 Zinc finger"," C2H2 type; PF12874 Zinc-finger of C2H2 type","K","KOG3623","Homeobox transcription factor SIP1","WP5097 CCL18 SIGNALING PATHWAY;WP4239 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER;WP2813 MAMMARY GLAND DEVELOPMENT PATHWAY EMBRYONIC DEVELOPMENT STAGE 1 OF 4;WP560 TGFBETA RECEPTOR SIGNALING;WP4816 TGFBETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS;WP366 TGFBETA SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5097_r119075;http://www.wikipathways.org/instance/WP4239_r118997;http://www.wikipathways.org/instance/WP2813_r102405;http://www.wikipathways.org/instance/WP560_r117838;http://www.wikipathways.org/instance/WP4816_r116440;http://www.wikipathways.org/instance/WP366_r120697","Transcription factor"]
["O60318","Germinal-center associated nuclear protein OS=Homo sapiens OX=9606 GN=MCM3AP PE=1 SV=2","MCM3AP",0.733397601,0.001591743,"down",11428.5,11392.7,10995.6,8468.39,8686,7646.77,1.169795059,1.166130653,1.125484408,0.866804986,0.889079047,0.782705846,"nucleus","K24317",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016973 poly(A)+ mRNA export from nucleus; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0045184 establishment of protein localization; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070390 transcription export complex 2;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"UD","KOG1860","Nuclear protein export factor"]
["O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma OS=Homo sapiens OX=9606 GN=PIP5K1C PE=1 SV=2","PIP5K1C",1.480476347,0.011771154,"nochange",5283.42,4067.86,5004.64,7629.21,6583.53,7040.86,0.890225985,0.685411092,0.843253153,1.285478153,1.109287067,1.186344551,"nucleus","K00889","PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]","hsa04666 Fc gamma R-mediated phagocytosis; hsa04510 Focal adhesion; hsa04072 Phospholipase D signaling pathway; hsa04810 Regulation of actin cytoskeleton; hsa05231 Choline metabolism in cancer; hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa04144 Endocytosis; hsa01100 Metabolic pathways; hsa05135 Yersinia infection","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001505 regulation of neurotransmitter levels; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002376 immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007310 oocyte dorsal/ventral axis specification; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007422 peripheral nervous system development; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007602 phototransduction; GO:0007603 phototransduction"," visible light; GO:0008103 oocyte microtubule cytoskeleton polarization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009584 detection of visible light; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009950 dorsal/ventral axis specification; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010511 regulation of phosphatidylinositol biosynthetic process; GO:0010513 positive regulation of phosphatidylinositol biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0016043 cellular component organization; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016325 oocyte microtubule cytoskeleton organization; GO:0016477 cell migration; GO:0017156 calcium-ion regulated exocytosis; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023061 signal release; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030168 platelet activation; GO:0030182 neuron differentiation; GO:0030198 extracellular matrix organization; GO:0030258 lipid modification; GO:0030593 neutrophil chemotaxis; GO:0030595 leukocyte chemotaxis; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity; GO:0030952 establishment or maintenance of cytoskeleton polarity; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032507 maintenance of protein location in cell; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032886 regulation of microtubule-based process; GO:0032887 regulation of spindle elongation; GO:0032888 regulation of mitotic spindle elongation; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033127 regulation of histone phosphorylation; GO:0033128 negative regulation of histone phosphorylation; GO:0034109 homotypic cell-cell adhesion; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034332 adherens junction organization; GO:0034333 adherens junction assembly; GO:0034613 cellular protein localization; GO:0036465 synaptic vesicle recycling; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0043062 extracellular structure organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044703 multi-organism reproductive process; GO:0045017 glycerolipid biosynthetic process; GO:0045055 regulated exocytosis; GO:0045185 maintenance of protein location; GO:0045216 cell-cell junction organization; GO:0045834 positive regulation of lipid metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046834 lipid phosphorylation; GO:0046854 phosphatidylinositol phosphate biosynthetic process; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048488 synaptic vesicle endocytosis; GO:0048489 synaptic vesicle transport; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051493 regulation of cytoskeleton organization; GO:0051606 detection of stimulus; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051651 maintenance of location in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051983 regulation of chromosome segregation; GO:0060236 regulation of mitotic spindle organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060326 cell chemotaxis; GO:0061024 membrane organization; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070527 platelet aggregation; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071071 regulation of phospholipid biosynthetic process; GO:0071073 positive regulation of phospholipid biosynthetic process; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071621 granulocyte chemotaxis; GO:0071704 organic substance metabolic process; GO:0071711 basement membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0072583 clathrin-dependent endocytosis; GO:0080090 regulation of primary metabolic process; GO:0090224 regulation of spindle organization; GO:0090407 organophosphate biosynthetic process; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0097529 myeloid leukocyte migration; GO:0097530 granulocyte migration; GO:0098609 cell-cell adhesion; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0104004 cellular response to environmental stimulus; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901576 organic substance biosynthetic process; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1903725 regulation of phospholipid metabolic process; GO:1903727 positive regulation of phospholipid metabolic process; GO:1904396 regulation of neuromuscular junction development; GO:1905268 negative regulation of chromatin organization; GO:1990266 neutrophil migration; GO:2000026 regulation of multicellular organismal development; GO:2001251 negative regulation of chromosome organization;","GO:0001726 ruffle; GO:0001891 phagocytic cup; GO:0001931 uropod; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005902 microvillus; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0005938 cell cortex; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016028 rhabdomere; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031254 cell trailing edge; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031528 microvillus membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032587 ruffle membrane; GO:0033583 rhabdomere membrane; GO:0035323 male germline ring canal; GO:0035996 rhabdomere microvillus; GO:0035997 rhabdomere microvillus membrane; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045171 intercellular bridge; GO:0045172 germline ring canal; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0008092 cytoskeletal protein binding; GO:0016301 kinase activity; GO:0016307 phosphatidylinositol phosphate kinase activity; GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity; GO:0052812 phosphatidylinositol-3","4-bisphosphate 5-kinase activity; GO:0052813 phosphatidylinositol bisphosphate kinase activity; GO:1990147 talin binding;",null,null,"T","KOG0229","Phosphatidylinositol-4-phosphate 5-kinase","WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP306 FOCAL ADHESION;WP4971 PHOSPHOINOSITIDES METABOLISM;WP51 REGULATION OF ACTIN CYTOSKELETON","http://www.wikipathways.org/instance/WP23_r120701;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP4971_r112223;http://www.wikipathways.org/instance/WP51_r116716",null,"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-162582 Signal Transduction;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-199991 Membrane Trafficking;R-HSA-373755 Semaphorin interactions;R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion;R-HSA-422475 Axon guidance;R-HSA-556833 Metabolism of lipids;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9675108 Nervous system development","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-199418;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-373755;https://reactome.org/PathwayBrowser/#/R-HSA-399955;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811558;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9675108"]
["O60333","Kinesin-like protein KIF1B OS=Homo sapiens OX=9606 GN=KIF1B PE=1 SV=5","KIF1B",0.737093416,2.813126E-3,"down",12527.3,11902.8,13803.1,9312.22,9180.05,9689.17,1.131735413,1.075317129,1.246993133,0.841280176,0.829339736,0.875334414,"nucleus","K10392",null,null,"GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007270 neuron-neuron synaptic transmission; GO:0007274 neuromuscular synaptic transmission; GO:0007275 multicellular organism development; GO:0008088 axo-dendritic transport; GO:0008089 anterograde axonal transport; GO:0008090 retrograde axonal transport; GO:0008104 protein localization; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010970 transport along microtubule; GO:0014070 response to organic cyclic compound; GO:0016482 cytosolic transport; GO:0017085 response to insecticide; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0032252 secretory granule localization; GO:0032253 dense core granule localization; GO:0032418 lysosome localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034643 establishment of mitochondrion localization"," microtubule-mediated; GO:0042221 response to chemical; GO:0046907 intracellular transport; GO:0047496 vesicle transport along microtubule; GO:0047497 mitochondrion transport along microtubule; GO:0048518 positive regulation of biological process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051654 establishment of mitochondrion localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0072384 organelle transport along microtubule; GO:0097327 response to antineoplastic agent; GO:0098916 anterograde trans-synaptic signaling; GO:0098930 axonal transport; GO:0099111 microtubule-based transport; GO:0099518 vesicle cytoskeletal trafficking; GO:0099519 dense core granule cytoskeletal transport; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:1901654 response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901950 dense core granule transport; GO:1904647 response to rotenone; GO:1990048 anterograde neuronal dense core vesicle transport; GO:1990049 retrograde neuronal dense core vesicle transport; GO:1990089 response to nerve growth factor; GO:1990090 cellular response to nerve growth factor stimulus; GO:1990778 protein localization to cell periphery;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005856 cytoskeleton; GO:0005871 kinesin complex; GO:0005875 microtubule associated complex; GO:0012506 vesicle membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0097708 intracellular vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0003774 cytoskeletal motor activity; GO:0003777 microtubule motor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0097110 scaffold protein binding;","PF00225; PF00169","PF00225 Kinesin motor domain; PF00169 PH domain","Z","KOG0245","Kinesin-like protein","WP4856 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY","http://www.wikipathways.org/instance/WP4856_r113654",null,"R-HSA-109582 Hemostasis;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-983189 Kinesins;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-983189;https://reactome.org/PathwayBrowser/#/R-HSA-983231","INFLAMMATORY RESPONSE;MITOTIC SPINDLE;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O60337","E3 ubiquitin-protein ligase MARCHF6 OS=Homo sapiens OX=9606 GN=MARCHF6 PE=1 SV=2","MARCHF6",1.152149324,0.589897542,"nochange",6453.46,4577.93,2698.51,4861.84,"NA",5684.09,1.329194512,0.94289876,0.5558018,1.001374618,"NA",1.170730311,"plasma membrane","K10661","MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]","hsa04141 Protein processing in endoplasmic reticulum","GO:0000209 protein polyubiquitination; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006517 protein deglycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034976 response to endoplasmic reticulum stress; GO:0035264 multicellular organism growth; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0036507 protein demannosylation; GO:0036508 protein alpha-1","2-demannosylation; GO:0040007 growth; GO:0042221 response to chemical; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0048589 developmental growth; GO:0050896 response to stimulus; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0070647 protein modification by small protein conjugation or removal; GO:0070936 protein K48-linked ubiquitination; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1904380 endoplasmic reticulum mannose trimming;","GO:0000151 ubiquitin ligase complex; GO:0000153 cytoplasmic ubiquitin ligase complex; GO:0000835 ER ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0002020 protease binding; GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0031624 ubiquitin conjugating enzyme binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044390 ubiquitin-like protein conjugating enzyme binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein; GO:1990381 ubiquitin-specific protease binding;","PF12906","PF12906 RING-variant domain","A","KOG1609","Protein involved in mRNA turnover and stability",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle;R-HSA-597592 Post-translational protein modification;R-HSA-901032 ER Quality Control Compartment (ERQC);R-HSA-901042 Calnexin/calreticulin cycle","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-532668;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-901032;https://reactome.org/PathwayBrowser/#/R-HSA-901042","XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["O60341","Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2","KDM1A",1.135799828,0.002934386,"up",57905.3,54983.3,57269.2,65827.3,63204.7,64233.2,0.955998382,0.907757076,0.94549657,1.086788123,1.043489818,1.060470031,"extracellular","K11450","KDM1A; [histone H3]-N6","N6-dimethyl-L-lysine4 FAD-dependent demethylase [EC:1.14.99.66]","hsa04714 Thermogenesis","GO:0000003 reproduction; GO:0000018 regulation of DNA recombination; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000902 cell morphogenesis; GO:0001701 in utero embryonic development; GO:0002009 morphogenesis of an epithelium; GO:0002052 positive regulation of neuroblast proliferation; GO:0002165 instar larval or pupal development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006144 purine nucleobase metabolic process; GO:0006282 regulation of DNA repair; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006476 protein deacetylation; GO:0006482 protein demethylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008152 metabolic process; GO:0008214 protein dealkylation; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008361 regulation of cell size; GO:0008593 regulation of Notch signaling pathway; GO:0009112 nucleobase metabolic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010212 response to ionizing radiation; GO:0010332 response to gamma radiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010569 regulation of double-strand break repair via homologous recombination; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010725 regulation of primitive erythrocyte differentiation; GO:0010817 regulation of hormone levels; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016570 histone modification; GO:0016575 histone deacetylation; GO:0016577 histone demethylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0021536 diencephalon development; GO:0021983 pituitary gland development; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030851 granulocyte differentiation; GO:0030900 forebrain development; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031061 negative regulation of histone methylation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032091 negative regulation of protein binding; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032350 regulation of hormone metabolic process; GO:0032352 positive regulation of hormone metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033169 histone H3-K9 demethylation; GO:0033182 regulation of histone ubiquitination; GO:0033184 positive regulation of histone ubiquitination; GO:0034641 cellular nitrogen compound metabolic process; GO:0034644 cellular response to UV; GO:0034720 histone H3-K4 demethylation; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035270 endocrine system development; GO:0035295 tube development; GO:0035561 regulation of chromatin binding; GO:0035563 positive regulation of chromatin binding; GO:0035601 protein deacylation; GO:0036211 protein modification process; GO:0040007 growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042692 muscle cell differentiation; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043392 negative regulation of DNA binding; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043516 regulation of DNA damage response"," signal transduction by p53 class mediator; GO:0043518 negative regulation of DNA damage response"," signal transduction by p53 class mediator; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045639 positive regulation of myeloid cell differentiation; GO:0045646 regulation of erythrocyte differentiation; GO:0045648 positive regulation of erythrocyte differentiation; GO:0045652 regulation of megakaryocyte differentiation; GO:0045654 positive regulation of megakaryocyte differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045793 positive regulation of cell size; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045995 regulation of embryonic development; GO:0046098 guanine metabolic process; GO:0046483 heterocycle metabolic process; GO:0046885 regulation of hormone biosynthetic process; GO:0046886 positive regulation of hormone biosynthetic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051100 negative regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051569 regulation of histone H3-K4 methylation; GO:0051570 regulation of histone H3-K9 methylation; GO:0051572 negative regulation of histone H3-K4 methylation; GO:0051573 negative regulation of histone H3-K9 methylation; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0055001 muscle cell development; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070076 histone lysine demethylation; GO:0070828 heterochromatin organization; GO:0070988 demethylation; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071480 cellular response to gamma radiation; GO:0071482 cellular response to light stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072091 regulation of stem cell proliferation; GO:0072521 purine-containing compound metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly; GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly; GO:0098732 macromolecule deacylation; GO:0104004 cellular response to environmental stimulus; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901797 negative regulation of signal transduction by p53 class mediator; GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902692 regulation of neuroblast proliferation; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1905268 negative regulation of chromatin organization; GO:1905269 positive regulation of chromatin organization; GO:1990138 neuron projection extension; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000179 positive regulation of neural precursor cell proliferation; GO:2000648 positive regulation of stem cell proliferation; GO:2000779 regulation of double-strand break repair; GO:2001020 regulation of response to DNA damage stimulus; GO:2001021 negative regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000781 chromosome"," telomeric region; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0017053 transcription repressor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1990391 DNA repair complex;","GO:0000166 nucleotide binding; GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0002039 p53 binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004407 histone deacetylase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016491 oxidoreductase activity; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016811 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in linear amides; GO:0019213 deacetylase activity; GO:0019899 enzyme binding; GO:0030374 nuclear receptor coactivator activity; GO:0032451 demethylase activity; GO:0032452 histone demethylase activity; GO:0032453 histone H3-methyl-lysine-4 demethylase activity; GO:0032454 histone H3-methyl-lysine-9 demethylase activity; GO:0033558 protein deacetylase activity; GO:0036094 small molecule binding; GO:0042162 telomeric DNA binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043425 bHLH transcription factor binding; GO:0043426 MRF binding; GO:0043565 sequence-specific DNA binding; GO:0050660 flavin adenine dinucleotide binding; GO:0050681 androgen receptor binding; GO:0051427 hormone receptor binding; GO:0061752 telomeric repeat-containing RNA binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF04433; PF01593","PF04433 SWIRM domain; PF01593 Flavin containing amine oxidoreductase","H","KOG0685","Flavin-containing amine oxidase","WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY;WP4320 EFFECT OF PROGERIN ON GENES INVOLVED IN HUTCHINSONGILFORD PROGERIA SYNDROME;WP4321 THERMOGENESIS;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS;WP4698 VITAMIN DSENSITIVE CALCIUM SIGNALING IN DEPRESSION","http://www.wikipathways.org/instance/WP138_r120688;http://www.wikipathways.org/instance/WP4320_r116686;http://www.wikipathways.org/instance/WP4321_r106178;http://www.wikipathways.org/instance/WP4746_r120402;http://www.wikipathways.org/instance/WP4698_r119119","Transcription factor","R-HSA-109582 Hemostasis;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-3214815 HDACs deacetylate histones;R-HSA-3214842 HDMs demethylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-5625740 RHO GTPases activate PKNs;R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;R-HSA-5663205 Infectious disease;R-HSA-6807070 PTEN Regulation;R-HSA-8939211 ESR-mediated signaling;R-HSA-8943724 Regulation of PTEN gene transcription;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9018519 Estrogen-dependent gene expression;R-HSA-9024446 NR1H2 and NR1H3-mediated signaling;R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux;R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-3214815;https://reactome.org/PathwayBrowser/#/R-HSA-3214842;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5625740;https://reactome.org/PathwayBrowser/#/R-HSA-5625886;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-8943724;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9018519;https://reactome.org/PathwayBrowser/#/R-HSA-9024446;https://reactome.org/PathwayBrowser/#/R-HSA-9029569;https://reactome.org/PathwayBrowser/#/R-HSA-9679191;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9716542;https://reactome.org/PathwayBrowser/#/R-HSA-983231"]
["O60343","TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2","TBC1D4",0.921767981,0.029899791,"nochange",25553.8,25245.1,25487,24553.1,23166,22598.8,1.045831008,1.033196957,1.043097109,1.004875726,0.948106393,0.924892806,"nucleus","K17902","TBC1D4; TBC1 domain family member 4","hsa04919 Thyroid hormone signaling pathway; hsa05415 Diabetic cardiomyopathy; hsa04931 Insulin resistance","GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0007155 cell adhesion; GO:0008104 protein localization; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010639 negative regulation of organelle organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022610 biological adhesion; GO:0031338 regulation of vesicle fusion; GO:0031339 negative regulation of vesicle fusion; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033627 cell adhesion mediated by integrin; GO:0034613 cellular protein localization; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043434 response to peptide hormone; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090630 activation of GTPase activity; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle;","GO:0005096 GTPase activator activity; GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0044877 protein-containing complex binding; GO:0050839 cell adhesion molecule binding; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00640","PF00640 Phosphotyrosine interaction domain (PTB/PID)","R","KOG4436","Predicted GTPase activator NB4S/EVI5 (contains TBC domain)/Calmodulin-binding protein Pollux (contains PTB and TBC domains)","WP4352 CILIARY LANDSCAPE;WP481 INSULIN SIGNALING;WP3635 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION;WP3634 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP3635_r116600;http://www.wikipathways.org/instance/WP3634_r116602;http://www.wikipathways.org/instance/WP4746_r120402",null,"R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-1445148;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656"]
["O60427","Acyl-CoA (8-3)-desaturase OS=Homo sapiens OX=9606 GN=FADS1 PE=1 SV=3","FADS1",0.615288714,0.000347613,"down",26504.1,27330.1,25334,15076.3,16995.8,16639.2,1.243550374,1.282305608,1.188650253,0.707367483,0.797428829,0.780697453,"plasma membrane","K10224","FADS1; acyl-CoA (8-3)-desaturase (Delta-5 desaturase) [EC:1.14.19.44]","hsa01040 Biosynthesis of unsaturated fatty acids; hsa01212 Fatty acid metabolism; hsa01100 Metabolic pathways","GO:0001676 long-chain fatty acid metabolic process; GO:0001889 liver development; GO:0006082 organic acid metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006636 unsaturated fatty acid biosynthetic process; GO:0006644 phospholipid metabolic process; GO:0006690 icosanoid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007584 response to nutrient; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009744 response to sucrose; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0014070 response to organic cyclic compound; GO:0016053 organic acid biosynthetic process; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019369 arachidonic acid metabolic process; GO:0019637 organophosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0032868 response to insulin; GO:0033189 response to vitamin A; GO:0033273 response to vitamin; GO:0033554 cellular response to stress; GO:0033559 unsaturated fatty acid metabolic process; GO:0033993 response to lipid; GO:0034285 response to disaccharide; GO:0035900 response to isolation stress; GO:0036109 alpha-linolenic acid metabolic process; GO:0042221 response to chemical; GO:0042594 response to starvation; GO:0042759 long-chain fatty acid biosynthetic process; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0043651 linoleic acid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0046394 carboxylic acid biosynthetic process; GO:0046456 icosanoid biosynthetic process; GO:0048513 animal organ development; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061008 hepaticobiliary system development; GO:0065007 biological regulation; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000248 C-5 sterol desaturase activity; GO:0003824 catalytic activity; GO:0016213 linoleoyl-CoA desaturase activity; GO:0016215 acyl-CoA desaturase activity; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016717 oxidoreductase activity"," acting on paired donors"," with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; GO:0045485 omega-6 fatty acid desaturase activity; GO:0070704 sterol desaturase activity;","PF00173; PF00487","PF00173 Cytochrome b5-like Heme/Steroid binding domain; PF00487 Fatty acid desaturase","I","KOG4232","Delta 6-fatty acid desaturase/delta-8 sphingolipid desaturase","WP4718 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCHRUSSELL PATHWAYS;WP4853 LINOLEIC ACID METABOLISM AFFECTED BY CORONAVIRUS INFECTION;WP4586 METABOLISM OF ALPHALINOLENIC ACID;WP4723 OMEGA3 OMEGA6 FATTY ACID SYNTHESIS;WP4724 OMEGA9 FATTY ACID SYNTHESIS","http://www.wikipathways.org/instance/WP4718_r119764;http://www.wikipathways.org/instance/WP4853_r119386;http://www.wikipathways.org/instance/WP4586_r119267;http://www.wikipathways.org/instance/WP4723_r120315;http://www.wikipathways.org/instance/WP4724_r117812",null,"R-HSA-1430728 Metabolism;R-HSA-1989781 PPARA activates gene expression;R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism;R-HSA-2046105 Linoleic acid (LA) metabolism;R-HSA-2046106 alpha-linolenic acid (ALA) metabolism;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1989781;https://reactome.org/PathwayBrowser/#/R-HSA-2046104;https://reactome.org/PathwayBrowser/#/R-HSA-2046105;https://reactome.org/PathwayBrowser/#/R-HSA-2046106;https://reactome.org/PathwayBrowser/#/R-HSA-400206;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868","ANDROGEN RESPONSE;BILE ACID METABOLISM;MTORC1 SIGNALING;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["O60443","Gasdermin-E OS=Homo sapiens OX=9606 GN=GSDME PE=1 SV=2","GSDME",0.731093533,0.007492164,"down",6046.68,5358.82,5467.43,3764.73,4485.01,4085.95,1.242101818,1.100802434,1.123112971,0.773346361,0.921305423,0.839330992,"cytoplasm","K22146",null,null,"GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0003008 system process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008219 cell death; GO:0008285 negative regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034097 response to cytokine; GO:0034612 response to tumor necrosis factor; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042490 mechanoreceptor differentiation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043207 response to external biotic stimulus; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043583 ear development; GO:0045937 positive regulation of phosphate metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050954 sensory perception of mechanical stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060113 inner ear receptor cell differentiation; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070265 necrotic cell death; GO:0070269 pyroptosis; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071356 cellular response to tumor necrosis factor; GO:0080090 regulation of primary metabolic process; GO:0098586 cellular response to virus; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;","GO:0005488 binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008289 lipid binding; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:1901611 phosphatidylglycerol binding; GO:1901612 cardiolipin binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF04598; PF17708","PF04598 Gasdermin pore forming domain; PF17708 Gasdermin PUB domain",{"$nulls":6},"R-HSA-109581 Apoptosis;R-HSA-109606 Intrinsic Pathway for Apoptosis;R-HSA-111457 Release of apoptotic factors from the mitochondria;R-HSA-111471 Apoptotic factor-mediated response;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-5218859 Regulated Necrosis;R-HSA-5357801 Programmed Cell Death;R-HSA-5620971 Pyroptosis;R-HSA-5686938 Regulation of TLR by endogenous ligand;R-HSA-9645723 Diseases of programmed cell death;R-HSA-9710421 Defective pyroptosis","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-109606;https://reactome.org/PathwayBrowser/#/R-HSA-111457;https://reactome.org/PathwayBrowser/#/R-HSA-111471;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168898;https://reactome.org/PathwayBrowser/#/R-HSA-5218859;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-5620971;https://reactome.org/PathwayBrowser/#/R-HSA-5686938;https://reactome.org/PathwayBrowser/#/R-HSA-9645723;https://reactome.org/PathwayBrowser/#/R-HSA-9710421","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O60449","Lymphocyte antigen 75 OS=Homo sapiens OX=9606 GN=LY75 PE=1 SV=3","LY75",0.466722944,0.008722449,"down",7211.37,7249.31,5334.04,3279.34,2380.31,3579,1.490292722,1.498133355,1.102326048,0.677704311,0.491911893,0.739631672,"peroxisome","K06559",null,null,"GO:0002376 immune system process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009987 cellular process; GO:0023052 signaling; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation;","GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0009897 external side of plasma membrane; GO:0009986 cell surface; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0071944 cell periphery; GO:0098552 side of membrane;","GO:0004888 transmembrane signaling receptor activity; GO:0038023 signaling receptor activity; GO:0060089 molecular transducer activity;","PF00040; PF00059","PF00040 Fibronectin type II domain; PF00059 Lectin C-type domain","TV","KOG4297","C-type lectin",{"$nulls":5},"ALLOGRAFT REJECTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION"]
["O60476","Mannosyl-oligosaccharide 1","2-alpha-mannosidase IB OS=Homo sapiens OX=9606 GN=MAN1A2 PE=1 SV=1","MAN1A2",1.459419422,0.017716365,"nochange",3422.84,4728.77,4032.79,6320.39,5653.2,5808.56,0.685332145,0.946809693,0.807458316,1.26548902,1.131902071,1.163008755,"mitochondria","K01230","MAN1A_C; mannosyl-oligosaccharide alpha-1","2-mannosidase [EC:3.2.1.113]","hsa00510 N-Glycan biosynthesis; hsa00513 Various types of N-glycan biosynthesis; hsa04141 Protein processing in endoplasmic reticulum; hsa01100 Metabolic pathways","GO:0006464 cellular protein modification process; GO:0006491 N-glycan processing; GO:0006517 protein deglycosylation; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007585 respiratory gaseous exchange by respiratory system; GO:0008152 metabolic process; GO:0009100 glycoprotein metabolic process; GO:0009987 cellular process; GO:0019538 protein metabolic process; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035295 tube development; GO:0036211 protein modification process; GO:0036507 protein demannosylation; GO:0036508 protein alpha-1","2-demannosylation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048286 lung alveolus development; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0060541 respiratory system development; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1904381 Golgi apparatus mannose trimming;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0004559 alpha-mannosidase activity; GO:0004571 mannosyl-oligosaccharide 1","2-alpha-mannosidase activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0015923 mannosidase activity; GO:0015924 mannosyl-oligosaccharide mannosidase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding;",null,null,"G","KOG2204","Mannosyl-oligosaccharide alpha-1","2-mannosidase and related glycosyl hydrolases",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6811438 Intra-Golgi traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-948021 Transport to the Golgi and subsequent modification;R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi;R-HSA-964827 Progressive trimming of alpha-1","2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6811438;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-948021;https://reactome.org/PathwayBrowser/#/R-HSA-964739;https://reactome.org/PathwayBrowser/#/R-HSA-964827"]
["O60488","Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2","ACSL4",1.053725131,0.003358945,"nochange",125859,124635,124768,131409,133754,130260,0.979847798,0.970318613,0.971354055,1.023056112,1.041312599,1.014110823,"endoplasmic reticulum","K01897","ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]","hsa00061 Fatty acid biosynthesis; hsa04216 Ferroptosis; hsa03320 PPAR signaling pathway; hsa00071 Fatty acid degradation; hsa04146 Peroxisome; hsa01212 Fatty acid metabolism; hsa04714 Thermogenesis; hsa04920 Adipocytokine signaling pathway; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001558 regulation of cell growth; GO:0001676 long-chain fatty acid metabolic process; GO:0003002 regionalization; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006638 neutral lipid metabolic process; GO:0006639 acylglycerol metabolic process; GO:0006641 triglyceride metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006655 phosphatidylglycerol biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007565 female pregnancy; GO:0007584 response to nutrient; GO:0008152 metabolic process; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010565 regulation of cellular ketone metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010876 lipid localization; GO:0010883 regulation of lipid storage; GO:0010884 positive regulation of lipid storage; GO:0010889 regulation of sequestering of triglyceride; GO:0010890 positive regulation of sequestering of triglyceride; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015849 organic acid transport; GO:0015908 fatty acid transport; GO:0015909 long-chain fatty acid transport; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0016192 vesicle-mediated transport; GO:0016358 dendrite development; GO:0016482 cytosolic transport; GO:0018130 heterocycle biosynthetic process; GO:0019216 regulation of lipid metabolic process; GO:0019217 regulation of fatty acid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019432 triglyceride biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030510 regulation of BMP signaling pathway; GO:0030514 negative regulation of BMP signaling pathway; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031667 response to nutrient levels; GO:0032303 regulation of icosanoid secretion; GO:0032304 negative regulation of icosanoid secretion; GO:0032306 regulation of prostaglandin secretion; GO:0032307 negative regulation of prostaglandin secretion; GO:0032368 regulation of lipid transport; GO:0032369 negative regulation of lipid transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032787 monocarboxylic acid metabolic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032890 regulation of organic acid transport; GO:0032891 negative regulation of organic acid transport; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034097 response to cytokine; GO:0034377 plasma lipoprotein particle assembly; GO:0034379 very-low-density lipoprotein particle assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035282 segmentation; GO:0035336 long-chain fatty-acyl-CoA metabolic process; GO:0035337 fatty-acyl-CoA metabolic process; GO:0035338 long-chain fatty-acyl-CoA biosynthetic process; GO:0035383 thioester metabolic process; GO:0035384 thioester biosynthetic process; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042996 regulation of Golgi to plasma membrane protein transport; GO:0042998 positive regulation of Golgi to plasma membrane protein transport; GO:0043062 extracellular structure organization; GO:0043269 regulation of ion transport; GO:0043271 negative regulation of ion transport; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044070 regulation of anion transport; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044539 long-chain fatty acid import into cell; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045017 glycerolipid biosynthetic process; GO:0045834 positive regulation of lipid metabolic process; GO:0045886 negative regulation of synaptic assembly at neuromuscular junction; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045937 positive regulation of phosphate metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046460 neutral lipid biosynthetic process; GO:0046463 acylglycerol biosynthetic process; GO:0046471 phosphatidylglycerol metabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0046907 intracellular transport; GO:0046942 carboxylic acid transport; GO:0046949 fatty-acyl-CoA biosynthetic process; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051964 negative regulation of synapse assembly; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060136 embryonic process involved in female pregnancy; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0060996 dendritic spine development; GO:0061502 early endosome to recycling endosome transport; GO:0061564 axon development; GO:0062012 regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065005 protein-lipid complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070672 response to interleukin-15; GO:0071071 regulation of phospholipid biosynthetic process; GO:0071073 positive regulation of phospholipid biosynthetic process; GO:0071616 acyl-CoA biosynthetic process; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071825 protein-lipid complex subunit organization; GO:0071827 plasma lipoprotein particle organization; GO:0071840 cellular component organization or biogenesis; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090288 negative regulation of cellular response to growth factor stimulus; GO:0090407 organophosphate biosynthetic process; GO:0097006 regulation of plasma lipoprotein particle levels; GO:0097485 neuron projection guidance; GO:0098916 anterograde trans-synaptic signaling; GO:0098927 vesicle-mediated transport between endosomal compartments; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903076 regulation of protein localization to plasma membrane; GO:1903078 positive regulation of protein localization to plasma membrane; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903725 regulation of phospholipid metabolic process; GO:1903727 positive regulation of phospholipid metabolic process; GO:1903792 negative regulation of anion transport; GO:1903829 positive regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904377 positive regulation of protein localization to cell periphery; GO:1904396 regulation of neuromuscular junction development; GO:1904397 negative regulation of neuromuscular junction development; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:1905809 negative regulation of synapse organization; GO:1905952 regulation of lipid localization; GO:1905953 negative regulation of lipid localization; GO:1905954 positive regulation of lipid localization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000191 regulation of fatty acid transport; GO:2000192 negative regulation of fatty acid transport; GO:2001141 regulation of RNA biosynthetic process; GO:2001245 regulation of phosphatidylcholine biosynthetic process; GO:2001247 positive regulation of phosphatidylcholine biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005777 peroxisome; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005811 lipid droplet; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031984 organelle subcompartment; GO:0036477 somatodendritic compartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042579 microbody; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044232 organelle membrane contact site; GO:0044233 mitochondria-associated endoplasmic reticulum membrane; GO:0044297 cell body; GO:0048471 perinuclear region of cytoplasm; GO:0098827 endoplasmic reticulum subcompartment; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004467 long-chain fatty acid-CoA ligase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0015645 fatty acid ligase activity; GO:0016405 CoA-ligase activity; GO:0016874 ligase activity; GO:0016877 ligase activity"," forming carbon-sulfur bonds; GO:0016878 acid-thiol ligase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0031957 very long-chain fatty acid-CoA ligase activity; GO:0047676 arachidonate-CoA ligase activity; GO:0090433 palmitoyl-CoA ligase activity;",null,null,"I","KOG1180","Acyl-CoA synthetase","WP4718 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCHRUSSELL PATHWAYS;WP143 FATTY ACID BETAOXIDATION;WP357 FATTY ACID BIOSYNTHESIS;WP5061 FATTY ACID TRANSPORTERS;WP4313 FERROPTOSIS;WP368 MITOCHONDRIAL LONG CHAIN FATTY ACID BETAOXIDATION;WP4723 OMEGA3 OMEGA6 FATTY ACID SYNTHESIS;WP4724 OMEGA9 FATTY ACID SYNTHESIS;WP3942 PPAR SIGNALING PATHWAY;WP4321 THERMOGENESIS","http://www.wikipathways.org/instance/WP4718_r119764;http://www.wikipathways.org/instance/WP143_r116506;http://www.wikipathways.org/instance/WP357_r117722;http://www.wikipathways.org/instance/WP5061_r115541;http://www.wikipathways.org/instance/WP4313_r120500;http://www.wikipathways.org/instance/WP368_r117795;http://www.wikipathways.org/instance/WP4723_r120315;http://www.wikipathways.org/instance/WP4724_r117812;http://www.wikipathways.org/instance/WP3942_r106517;http://www.wikipathways.org/instance/WP4321_r106178",null,"R-HSA-1430728 Metabolism;R-HSA-163685 Integration of energy metabolism;R-HSA-400451 Free fatty acids regulate insulin secretion;R-HSA-422356 Regulation of insulin secretion;R-HSA-434313 Intracellular metabolism of fatty acids regulates insulin secretion;R-HSA-556833 Metabolism of lipids;R-HSA-75105 Fatty acyl-CoA biosynthesis;R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163685;https://reactome.org/PathwayBrowser/#/R-HSA-400451;https://reactome.org/PathwayBrowser/#/R-HSA-422356;https://reactome.org/PathwayBrowser/#/R-HSA-434313;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-75105;https://reactome.org/PathwayBrowser/#/R-HSA-75876;https://reactome.org/PathwayBrowser/#/R-HSA-8978868","FATTY ACID METABOLISM;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["O60493","Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3","SNX3",1.266486535,0.005350319,"up",100233,106027,98776.8,133384,119427,133514,0.8698745,0.920157868,0.857236833,1.15757625,1.03645009,1.158704458,"cytoplasm","K17918","SNX3_12; sorting nexin-3/12","hsa04144 Endocytosis","GO:0000041 transition metal ion transport; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006725 cellular aromatic compound metabolic process; GO:0006778 porphyrin-containing compound metabolic process; GO:0006779 porphyrin-containing compound biosynthetic process; GO:0006783 heme biosynthetic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006826 iron ion transport; GO:0006897 endocytosis; GO:0006900 vesicle budding from membrane; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010324 membrane invagination; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016055 Wnt signaling pathway; GO:0016192 vesicle-mediated transport; GO:0016579 protein deubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0020027 hemoglobin metabolic process; GO:0022008 neurogenesis; GO:0022406 membrane docking; GO:0022615 protein to membrane docking; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030001 metal ion transport; GO:0030100 regulation of endocytosis; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032268 regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033013 tetrapyrrole metabolic process; GO:0033014 tetrapyrrole biosynthetic process; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033572 transferrin transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0042168 heme metabolic process; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042440 pigment metabolic process; GO:0042541 hemoglobin biosynthetic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045806 negative regulation of endocytosis; GO:0046148 pigment biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046596 regulation of viral entry into host cell; GO:0046597 negative regulation of viral entry into host cell; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050764 regulation of phagocytosis; GO:0050765 negative regulation of phagocytosis; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070676 intralumenal vesicle formation; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0098657 import into cell; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0198738 cell-cell signaling by wnt; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903649 regulation of cytoplasmic transport; GO:1903650 negative regulation of cytoplasmic transport; GO:1903900 regulation of viral life cycle; GO:1903901 negative regulation of viral life cycle; GO:1904950 negative regulation of establishment of protein localization; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:2000026 regulation of multicellular organismal development; GO:2000641 regulation of early endosome to late endosome transport; GO:2000642 negative regulation of early endosome to late endosome transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031982 vesicle; GO:0032009 early phagosome; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0045335 phagocytic vesicle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0010314 phosphatidylinositol-5-phosphate binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0070273 phosphatidylinositol-4-phosphate binding; GO:0080025 phosphatidylinositol-3","5-bisphosphate binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00787","PF00787 PX domain","U","KOG2527","Sorting nexin SNX11",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-195721 Signaling by WNT;R-HSA-3238698 WNT ligand biogenesis and trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-3238698;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689880;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["O60496","Docking protein 2 OS=Homo sapiens OX=9606 GN=DOK2 PE=1 SV=2","DOK2",0.927842253,0.194459113,"nochange",41631.8,42501.2,41987.9,42427.1,38822,35771.2,1.027348718,1.048802918,1.036136204,1.046974351,0.95801123,0.88272658,"nucleus","K20234",null,null,"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002376 immune system process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007275 multicellular organism development; GO:0007391 dorsal closure; GO:0007392 initiation of dorsal closure; GO:0007394 dorsal closure"," elongation of leading edge cells; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008360 regulation of cell shape; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009826 unidimensional cell growth; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016331 morphogenesis of embryonic epithelium; GO:0016476 regulation of embryonic cell shape; GO:0016477 cell migration; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033554 cellular response to stress; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0040007 growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0045936 negative regulation of phosphate metabolic process; GO:0045995 regulation of embryonic development; GO:0046528 imaginal disc fusion; GO:0046529 imaginal disc fusion"," thorax closure; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0097485 neuron projection guidance; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005938 cell cortex; GO:0071944 cell periphery; GO:0099568 cytoplasmic region;","GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030674 protein-macromolecule adaptor activity; GO:0030971 receptor tyrosine kinase binding; GO:0035591 signaling adaptor activity; GO:0060090 molecular adaptor activity; GO:1990782 protein tyrosine kinase binding;","PF02174","PF02174 PTB domain (IRS-1 type)","T","KOG4047","Docking protein 1 (p62dok)","WP437 EGFEGFR SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP3303 RAC1PAK1P38MMP2 PATHWAY","http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP3303_r120561",null,"R-HSA-109582 Hemostasis;R-HSA-1266738 Developmental Biology;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-210993 Tie2 Signaling;R-HSA-422475 Axon guidance;R-HSA-8853659 RET signaling;R-HSA-9675108 Nervous system development","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-202733;https://reactome.org/PathwayBrowser/#/R-HSA-210993;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-8853659;https://reactome.org/PathwayBrowser/#/R-HSA-9675108"]
["O60499","Syntaxin-10 OS=Homo sapiens OX=9606 GN=STX10 PE=1 SV=1","STX10",1.048524459,0.248657444,"nochange",27487.3,25596.6,24765.5,28183.5,26824.5,26619,1.034158032,0.963023996,0.93175542,1.060351249,1.009221427,1.001489876,"cytoplasm","K23937","STX10; syntaxin 10","hsa05132 Salmonella infection","GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006906 vesicle fusion; GO:0006996 organelle organization; GO:0008104 protein localization; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0022406 membrane docking; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048278 vesicle docking; GO:0048284 organelle fusion; GO:0050789 regulation of biological process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090174 organelle membrane fusion; GO:0140056 organelle localization by membrane tethering;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031224 intrinsic component of membrane; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex;","GO:0000149 SNARE binding; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019905 syntaxin binding;","PF09177","PF09177 Syntaxin 6"," N-terminal","U","KOG3202","SNARE protein TLG1/Syntaxin 6",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442"]
["O60502","Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2","OGA",0.517259111,0.000189981,"down",28183.6,25541,29703.8,14480.5,13776.3,14897.3,1.335900302,1.210641281,1.407957656,0.686374499,0.652995477,0.706130784,"cytoplasm","K15719","NCOAT; protein O-GlcNAcase / histone acetyltransferase [EC:3.2.1.169 2.3.1.48]","hsa04931 Insulin resistance","GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003254 regulation of membrane depolarization; GO:0005975 carbohydrate metabolic process; GO:0005976 polysaccharide metabolic process; GO:0005977 glycogen metabolic process; GO:0006040 amino sugar metabolic process; GO:0006044 N-acetylglucosamine metabolic process; GO:0006073 cellular glucan metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006112 energy reserve metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006325 chromatin organization; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006486 protein glycosylation; GO:0006491 N-glycan processing; GO:0006493 protein O-linked glycosylation; GO:0006516 glycoprotein catabolic process; GO:0006517 protein deglycosylation; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007610 behavior; GO:0007622 rhythmic behavior; GO:0007623 circadian rhythm; GO:0007626 locomotory behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009151 purine deoxyribonucleotide metabolic process; GO:0009200 deoxyribonucleoside triphosphate metabolic process; GO:0009215 purine deoxyribonucleoside triphosphate metabolic process; GO:0009262 deoxyribonucleotide metabolic process; GO:0009394 2'-deoxyribonucleotide metabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010522 regulation of calcium ion transport into cytosol; GO:0010524 positive regulation of calcium ion transport into cytosol; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010561 negative regulation of glycoprotein biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010612 regulation of cardiac muscle adaptation; GO:0010616 negative regulation of cardiac muscle adaptation; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010876 lipid localization; GO:0010959 regulation of metal ion transport; GO:0014070 response to organic cyclic compound; GO:0014745 negative regulation of muscle adaptation; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016311 dephosphorylation; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019692 deoxyribose phosphate metabolic process; GO:0019725 cellular homeostasis; GO:0019915 lipid storage; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030003 cellular cation homeostasis; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031341 regulation of cell killing; GO:0031343 positive regulation of cell killing; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032024 positive regulation of insulin secretion; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0036211 protein modification process; GO:0040024 dauer larval development; GO:0042221 response to chemical; GO:0042391 regulation of membrane potential; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043243 positive regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0043502 regulation of muscle adaptation; GO:0043543 protein acylation; GO:0044042 glucan metabolic process; GO:0044057 regulation of system process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044264 cellular polysaccharide metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0045184 establishment of protein localization; GO:0045475 locomotor rhythm; GO:0045862 positive regulation of proteolysis; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046060 dATP metabolic process; GO:0046324 regulation of glucose import; GO:0046326 positive regulation of glucose import; GO:0046483 heterocycle metabolic process; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0046907 intracellular transport; GO:0048511 rhythmic process; GO:0048512 circadian behavior; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051480 regulation of cytosolic calcium ion concentration; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051881 regulation of mitochondrial membrane potential; GO:0051900 regulation of mitochondrial depolarization; GO:0051901 positive regulation of mitochondrial depolarization; GO:0051924 regulation of calcium ion transport; GO:0051928 positive regulation of calcium ion transport; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060049 regulation of protein glycosylation; GO:0060051 negative regulation of protein glycosylation; GO:0060123 regulation of growth hormone secretion; GO:0060124 positive regulation of growth hormone secretion; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070085 glycosylation; GO:0070201 regulation of establishment of protein localization; GO:0070265 necrotic cell death; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0072521 purine-containing compound metabolic process; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090150 establishment of protein localization to membrane; GO:0090257 regulation of muscle system process; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:0098771 inorganic ion homeostasis; GO:1901071 glucosamine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1903018 regulation of glycoprotein metabolic process; GO:1903019 negative regulation of glycoprotein metabolic process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904181 positive regulation of membrane depolarization; GO:1904951 positive regulation of establishment of protein localization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004402 histone acetyltransferase activity; GO:0004415 hyalurononglucosaminidase activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0004563 beta-N-acetylhexosaminidase activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004722 protein serine/threonine phosphatase activity; GO:0008080 N-acetyltransferase activity; GO:0015929 hexosaminidase activity; GO:0016231 beta-N-acetylglucosaminidase activity; GO:0016407 acetyltransferase activity; GO:0016410 N-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0034212 peptide N-acetyltransferase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0061733 peptide-lysine-N-acetyltransferase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG3698","Hyaluronoglucosaminidase"]
["O60504","Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2","SORBS3",0.941413963,0.789886058,"nochange",3249.47,3575.24,5264.86,2711.26,4546.04,4123.99,0.830681961,0.913960545,1.345888476,0.693096035,1.162132108,1.054240876,"nucleus","K23709",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0003008 system process; GO:0003012 muscle system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006936 muscle contraction; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007155 cell adhesion; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031589 cell-substrate adhesion; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051496 positive regulation of stress fiber assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0070161 anchoring junction;","GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008134 transcription factor binding; GO:0017166 vinculin binding;","PF14604; PF00018","PF14604 Variant SH3 domain; PF00018 SH3 domain","T","KOG4225","Sorbin and SH3 domain-containing protein",{"$nulls":3},"R-HSA-397014 Muscle contraction;R-HSA-445355 Smooth Muscle Contraction","https://reactome.org/PathwayBrowser/#/R-HSA-397014;https://reactome.org/PathwayBrowser/#/R-HSA-445355","APICAL JUNCTION;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["O60506","Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2","SYNCRIP",1.074749891,0.022942435,"nochange",212484,208862,222374,232595,227169,232074,0.954585274,0.938313424,0.999016142,1.044934028,1.020557699,1.042593433,"nucleus","K13160",null,null,"GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002376 immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007310 oocyte dorsal/ventral axis specification; GO:0007389 pattern specification process; GO:0007623 circadian rhythm; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009950 dorsal/ventral axis specification; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010927 cellular component assembly involved in morphogenesis; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0017148 negative regulation of translation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0030154 cell differentiation; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0034097 response to cytokine; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034341 response to interferon-gamma; GO:0034641 cellular nitrogen compound metabolic process; GO:0040008 regulation of growth; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0043489 RNA stabilization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0045087 innate immune response; GO:0045727 positive regulation of translation; GO:0045886 negative regulation of synaptic assembly at neuromuscular junction; GO:0045926 negative regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046011 regulation of oskar mRNA translation; GO:0046483 heterocycle metabolic process; GO:0046843 dorsal appendage formation; GO:0048255 mRNA stabilization; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048511 rhythmic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051964 negative regulation of synapse assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0061013 regulation of mRNA catabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0070934 CRD-mediated mRNA stabilization; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090365 regulation of mRNA modification; GO:0090367 negative regulation of mRNA modification; GO:0099177 regulation of trans-synaptic signaling; GO:1900073 regulation of neuromuscular synaptic transmission; GO:1901360 organic cyclic compound metabolic process; GO:1902369 negative regulation of RNA catabolic process; GO:1902373 negative regulation of mRNA catabolic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1904396 regulation of neuromuscular junction development; GO:1904397 negative regulation of neuromuscular junction development; GO:1905809 negative regulation of synapse organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005681 spliceosomal complex; GO:0005737 cytoplasm; GO:0016020 membrane; GO:0030425 dendrite; GO:0031594 neuromuscular junction; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0045202 synapse; GO:0070937 CRD-mediated mRNA stability complex; GO:0071013 catalytic step 2 spliceosome; GO:0071204 histone pre-mRNA 3'end processing complex; GO:0097447 dendritic tree; GO:0097452 GAIT complex; GO:0098794 postsynapse; GO:0098975 postsynapse of neuromuscular junction; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1990635 proximal dendrite; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0005488 binding; GO:0008143 poly(A) binding; GO:0048027 mRNA 5'-UTR binding; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF18360; PF00076","PF18360 Heterogeneous nuclear ribonucleoprotein Q acidic domain; PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","A","KOG0117","Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)",null,null,"Transcription factor",null,null,"E2F TARGETS;G2M CHECKPOINT;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["O60508","Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1","CDC40",1.461652384,{"v":1.58338e-05,"d":"1.58E-05"},"up",25390.3,25744.4,26381.2,36982.5,38227.1,38091.7,0.798365137,0.809499353,0.829522706,1.162866869,1.202001706,1.197744229,"nucleus","K12816","CDC40; pre-mRNA-processing factor 17","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071007 U2-type catalytic step 2 spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"S","KOG0282","mRNA splicing factor","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O60524","Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4","NEMF",0.648870226,0.00603415,"down",15430.8,19041.7,18489.4,10582.6,12460.6,11322.2,1.060204541,1.308298779,1.270351883,0.727099086,0.856130901,0.77791481,"cytoplasm","K24971",null,null,"GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901798 positive regulation of signal transduction by p53 class mediator; GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:2001020 regulation of response to DNA damage stimulus; GO:2001022 positive regulation of response to DNA damage stimulus; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;",null,null,"PF05670; PF11923","PF05670 NFACT protein RNA binding domain; PF11923 NFACT protein C-terminal domain","R","KOG2030","Predicted RNA-binding protein"]
["O60547","GDP-mannose 4","6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1","GMDS",1.130527163,0.122418103,"nochange",22419.7,20354.3,25045.6,26591.3,24515.6,25565,0.930976563,0.845210964,1.040016887,1.104201977,1.018008672,1.061584938,"mitochondria","K01711","gmd; GDPmannose 4","6-dehydratase [EC:4.2.1.47]","hsa01250 Biosynthesis of nucleotide sugars; hsa00051 Fructose and mannose metabolism; hsa00520 Amino sugar and nucleotide sugar metabolism; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009226 nucleotide-sugar biosynthetic process; GO:0009987 cellular process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019673 GDP-mannose metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042350 GDP-L-fucose biosynthetic process; GO:0042351 'de novo' GDP-L-fucose biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0046368 GDP-L-fucose metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051302 regulation of cell division; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:2000035 regulation of stem cell division;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008446 GDP-mannose 4","6-dehydratase activity; GO:0016829 lyase activity; GO:0016835 carbon-oxygen lyase activity; GO:0016836 hydro-lyase activity; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0050661 NADP binding; GO:0070401 NADP+ binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF16363","PF16363 GDP-mannose 4","6 dehydratase","G","KOG1372","GDP-mannose 4","6 dehydratase",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide"," LLO) and transfer to a nascent protein;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-446219 Synthesis of substrates in N-glycan biosythesis;R-HSA-597592 Post-translational protein modification;R-HSA-6787639 GDP-fucose biosynthesis","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446193;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-446219;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6787639"]
["O60551","Glycylpeptide N-tetradecanoyltransferase 2 OS=Homo sapiens OX=9606 GN=NMT2 PE=1 SV=1","NMT2",0.991662702,0.717884561,"nochange",5338.15,5179.86,5519.56,5367.43,5341.64,5194.79,1.00273845,0.973004653,1.036815196,1.008238517,1.003394025,0.975809161,"nucleus","K00671",null,null,"GO:0001700 embryonic development via the syncytial blastoderm; GO:0002009 morphogenesis of an epithelium; GO:0006464 cellular protein modification process; GO:0006497 protein lipidation; GO:0006498 N-terminal protein lipidation; GO:0006499 N-terminal protein myristoylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007275 multicellular organism development; GO:0007391 dorsal closure; GO:0008152 metabolic process; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0018008 N-terminal peptidyl-glycine N-myristoylation; GO:0018193 peptidyl-amino acid modification; GO:0018201 peptidyl-glycine modification; GO:0018377 protein myristoylation; GO:0019058 viral life cycle; GO:0019538 protein metabolic process; GO:0022400 regulation of rhodopsin mediated signaling pathway; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031365 N-terminal protein amino acid modification; GO:0032101 regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0042157 lipoprotein metabolic process; GO:0042158 lipoprotein biosynthetic process; GO:0042180 cellular ketone metabolic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043543 protein acylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0046794 transport of virus; GO:0046902 regulation of mitochondrial membrane permeability; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0075733 intracellular transport of virus; GO:0090559 regulation of membrane permeability; GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903747 regulation of establishment of protein localization to mitochondrion; GO:1903749 positive regulation of establishment of protein localization to mitochondrion; GO:1903829 positive regulation of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0003824 catalytic activity; GO:0004379 glycylpeptide N-tetradecanoyltransferase activity; GO:0016410 N-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0019107 myristoyltransferase activity;","PF01233; PF02799","PF01233 Myristoyl-CoA:protein N-myristoyltransferase"," N-terminal domain; PF02799 Myristoyl-CoA:protein N-myristoyltransferase"," C-terminal domain","I","KOG2779","N-myristoyl transferase",{"$nulls":3},"R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-174490 Membrane binding and targetting of GAG proteins;R-HSA-174495 Synthesis And Processing Of GAG"," GAGPOL Polyproteins;R-HSA-175474 Assembly Of The HIV Virion;R-HSA-2187338 Visual phototransduction;R-HSA-2514856 The phototransduction cascade;R-HSA-2514859 Inactivation"," recovery and regulation of the phototransduction cascade;R-HSA-5663205 Infectious disease;R-HSA-9709957 Sensory Perception","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-174490;https://reactome.org/PathwayBrowser/#/R-HSA-174495;https://reactome.org/PathwayBrowser/#/R-HSA-175474;https://reactome.org/PathwayBrowser/#/R-HSA-2187338;https://reactome.org/PathwayBrowser/#/R-HSA-2514856;https://reactome.org/PathwayBrowser/#/R-HSA-2514859;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-9709957"]
["O60563","Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1","CCNT1",1.14040044,0.236530647,"nochange",7005.32,5739.91,7916.03,8361.19,7770.48,7430.44,0.950445884,0.778761546,1.074006346,1.134403371,1.054258868,1.008123985,"nucleus","K15188","CCNT; cyclin T","hsa03250 Viral life cycle - HIV-1; hsa05202 Transcriptional misregulation in cancer","GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009266 response to temperature stimulus; GO:0009301 snRNA transcription; GO:0009408 response to heat; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016032 viral process; GO:0016070 RNA metabolic process; GO:0016073 snRNA metabolic process; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019080 viral gene expression; GO:0019083 viral transcription; GO:0019085 early viral transcription; GO:0019086 late viral transcription; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031440 regulation of mRNA 3'-end processing; GO:0031441 negative regulation of mRNA 3'-end processing; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032774 RNA biosynthetic process; GO:0033674 positive regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0035821 modulation of process of another organism; GO:0036211 protein modification process; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042795 snRNA transcription by RNA polymerase II; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043921 modulation by host of viral transcription; GO:0043923 positive regulation by host of viral transcription; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045595 regulation of cell differentiation; GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045787 positive regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046782 regulation of viral transcription; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0050434 positive regulation of viral transcription; GO:0050684 regulation of mRNA processing; GO:0050686 negative regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051147 regulation of muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051702 biological process involved in interaction with symbiont; GO:0051726 regulation of cell cycle; GO:0051851 modulation by host of symbiont process; GO:0052472 modulation by host of symbiont transcription; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098781 ncRNA transcription; GO:1900363 regulation of mRNA polyadenylation; GO:1900364 negative regulation of mRNA polyadenylation; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain; GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904031 positive regulation of cyclin-dependent protein kinase activity; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000307 cyclin-dependent protein kinase holoenzyme complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0008023 transcription elongation factor complex; GO:0008024 cyclin/CDK positive transcription elongation factor complex; GO:0016020 membrane; GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032783 super elongation complex; GO:0032806 carboxy-terminal domain protein kinase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0001067 transcription regulatory region nucleic acid binding; GO:0001221 transcription coregulator binding; GO:0001223 transcription coactivator binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016301 kinase activity; GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017069 snRNA binding; GO:0019207 kinase regulator activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0070063 RNA polymerase binding; GO:0097159 organic cyclic compound binding; GO:0097322 7SK snRNA binding; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;","PF00134","PF00134 Cyclin"," N-terminal domain","D","KOG0834","CDK9 kinase-activating protein cyclin T","WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR;WP4673 MALE INFERTILITY","http://www.wikipathways.org/instance/WP3414_r106735;http://www.wikipathways.org/instance/WP4673_r119920",null,"R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-162582 Signal Transduction;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation;R-HSA-167243 Tat-mediated HIV elongation arrest and recovery;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-167287 HIV elongation arrest and recovery;R-HSA-167290 Pausing and recovery of HIV elongation;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-176034 Interactions of Tat with host cellular proteins;R-HSA-212436 Generic Transcription Pathway;R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer;R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5663205 Infectious disease;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6807505 RNA polymerase II transcribes snRNA genes;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006936 Signaling by TGFB family members;R-HSA-9018519 Estrogen-dependent gene expression","https://reactome.org/PathwayBrowser/#/R-HSA-112382;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-162909;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-167152;https://reactome.org/PathwayBrowser/#/R-HSA-167169;https://reactome.org/PathwayBrowser/#/R-HSA-167172;https://reactome.org/PathwayBrowser/#/R-HSA-167200;https://reactome.org/PathwayBrowser/#/R-HSA-167238;https://reactome.org/PathwayBrowser/#/R-HSA-167243;https://reactome.org/PathwayBrowser/#/R-HSA-167246;https://reactome.org/PathwayBrowser/#/R-HSA-167287;https://reactome.org/PathwayBrowser/#/R-HSA-167290;https://reactome.org/PathwayBrowser/#/R-HSA-170834;https://reactome.org/PathwayBrowser/#/R-HSA-176034;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2173793;https://reactome.org/PathwayBrowser/#/R-HSA-2173796;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-674695;https://reactome.org/PathwayBrowser/#/R-HSA-6796648;https://reactome.org/PathwayBrowser/#/R-HSA-6807505;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75955;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9006936;https://reactome.org/PathwayBrowser/#/R-HSA-9018519","G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3","BUB1B",0.927505639,0.359218963,"nochange",9958.17,10968.5,9539.01,9063.85,8601.94,10591.3,1.017476185,1.12070667,0.974648505,0.926099024,0.878903362,1.082166253,"nucleus","K06637","BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]","hsa04110 Cell cycle; hsa05166 Human T-cell leukemia virus 1 infection","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007062 sister chromatid cohesion; GO:0007088 regulation of mitotic nuclear division; GO:0007091 metaphase/anaphase transition of mitotic cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007094 mitotic spindle assembly checkpoint signaling; GO:0007135 meiosis II; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030163 protein catabolic process; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0031577 spindle checkpoint signaling; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0033365 protein localization to organelle; GO:0034501 protein localization to kinetochore; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044784 metaphase/anaphase transition of cell cycle; GO:0045132 meiotic chromosome segregation; GO:0045144 meiotic sister chromatid segregation; GO:0045786 negative regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045841 negative regulation of mitotic metaphase/anaphase transition; GO:0045930 negative regulation of mitotic cell cycle; GO:0048285 organelle fission; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051177 meiotic sister chromatid cohesion; GO:0051179 localization; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051726 regulation of cell cycle; GO:0051754 meiotic sister chromatid cohesion"," centromeric; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0061983 meiosis II cell cycle process; GO:0065007 biological regulation; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070601 centromeric sister chromatid cohesion; GO:0070727 cellular macromolecule localization; GO:0071173 spindle assembly checkpoint signaling; GO:0071174 mitotic spindle checkpoint signaling; GO:0071459 protein localization to chromosome"," centromeric region; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001251 negative regulation of chromosome organization;","GO:0000151 ubiquitin ligase complex; GO:0000152 nuclear ubiquitin ligase complex; GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000940 outer kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005680 anaphase-promoting complex; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0051233 spindle midzone; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0140096 catalytic activity"," acting on a protein;","PF08311","PF08311 Mad3/BUB1 homology region 1","D","KOG1166","Mitotic checkpoint serine/threonine protein kinase","WP4240 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASEANAPHASE TRANSITION","http://www.wikipathways.org/instance/WP4240_r106495",null,"R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-141405;https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141430;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-174143;https://reactome.org/PathwayBrowser/#/R-HSA-174184;https://reactome.org/PathwayBrowser/#/R-HSA-176408;https://reactome.org/PathwayBrowser/#/R-HSA-176409;https://reactome.org/PathwayBrowser/#/R-HSA-176814;https://reactome.org/PathwayBrowser/#/R-HSA-179409;https://reactome.org/PathwayBrowser/#/R-HSA-179419;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-453276;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["O60568","Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1","PLOD3",1.009793249,0.791605401,"nochange",24881.1,24014.5,25880.4,23955.9,25376.6,26175.8,0.993361249,0.958762825,1.033257632,0.956423259,1.013143755,1.045051279,"extracellular","K13646","PLOD3; lysyl hydroxylase/galactosyltransferase/glucosyltransferase [EC:1.14.11.4 2.4.1.50 2.4.1.66]","hsa00514 Other types of O-glycan biosynthesis; hsa00310 Lysine degradation; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001666 response to hypoxia; GO:0001701 in utero embryonic development; GO:0001885 endothelial cell development; GO:0001886 endothelial cell morphogenesis; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0003158 endothelium development; GO:0003382 epithelial cell morphogenesis; GO:0006011 UDP-glucose metabolic process; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006520 cellular amino acid metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007295 growth of a germarium-derived egg chamber; GO:0007399 nervous system development; GO:0008015 blood circulation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008544 epidermis development; GO:0008652 cellular amino acid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009066 aspartate family amino acid metabolic process; GO:0009067 aspartate family amino acid biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0017185 peptidyl-lysine hydroxylation; GO:0018126 protein hydroxylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019953 sexual reproduction; GO:0021915 neural tube development; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030198 extracellular matrix organization; GO:0030199 collagen fibril organization; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0030855 epithelial cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0032963 collagen metabolic process; GO:0032964 collagen biosynthetic process; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035150 regulation of tube size; GO:0035295 tube development; GO:0035296 regulation of tube diameter; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0040007 growth; GO:0042221 response to chemical; GO:0042311 vasodilation; GO:0042398 cellular modified amino acid biosynthetic process; GO:0043009 chordate embryonic development; GO:0043062 extracellular structure organization; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0043436 oxoacid metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045446 endothelial cell differentiation; GO:0046394 carboxylic acid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046946 hydroxylysine metabolic process; GO:0046947 hydroxylysine biosynthetic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048729 tissue morphogenesis; GO:0048730 epidermis morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060425 lung morphogenesis; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070085 glycosylation; GO:0070482 response to oxygen levels; GO:0070831 basement membrane assembly; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071711 basement membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0097359 UDP-glucosylation; GO:0097435 supramolecular fiber organization; GO:0097746 blood vessel diameter maintenance; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901607 alpha-amino acid biosynthetic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005791 rough endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030867 rough endoplasmic reticulum membrane; GO:0031012 extracellular matrix; GO:0031090 organelle membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0062023 collagen-containing extracellular matrix; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008194 UDP-glycosyltransferase activity; GO:0008378 galactosyltransferase activity; GO:0008475 procollagen-lysine 5-dioxygenase activity; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0033823 procollagen glucosyltransferase activity; GO:0035250 UDP-galactosyltransferase activity; GO:0035251 UDP-glucosyltransferase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046527 glucosyltransferase activity; GO:0046983 protein dimerization activity; GO:0050211 procollagen galactosyltransferase activity; GO:0051213 dioxygenase activity; GO:0070815 peptidyl-lysine 5-dioxygenase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG1971","Lysyl hydroxylase","WP4754 IL18 SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1474244 Extracellular matrix organization;R-HSA-1474290 Collagen formation;R-HSA-1650814 Collagen biosynthesis and modifying enzymes","https://reactome.org/PathwayBrowser/#/R-HSA-1474244;https://reactome.org/PathwayBrowser/#/R-HSA-1474290;https://reactome.org/PathwayBrowser/#/R-HSA-1650814","EPITHELIAL MESENCHYMAL TRANSITION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"]
["O60573","Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1","EIF4E2",0.869750669,0.070237978,"nochange",25529.5,25660.8,25402.8,22569.4,24204.4,19843.1,1.069597095,1.075098108,1.064288807,0.945579219,1.014080022,0.831356749,"cytoplasm","K03259","EIF4E; translation initiation factor 4E","hsa04066 HIF-1 signaling pathway; hsa04211 Longevity regulating pathway; hsa04150 mTOR signaling pathway; hsa01521 EGFR tyrosine kinase inhibitor resistance; hsa04151 PI3K-Akt signaling pathway; hsa04910 Insulin signaling pathway","GO:0001701 in utero embryonic development; GO:0006412 translation; GO:0006417 regulation of translation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007553 regulation of ecdysteroid metabolic process; GO:0007554 regulation of ecdysteroid biosynthetic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010565 regulation of cellular ketone metabolic process; GO:0010566 regulation of ketone biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010817 regulation of hormone levels; GO:0010893 positive regulation of steroid biosynthetic process; GO:0017148 negative regulation of translation; GO:0019216 regulation of lipid metabolic process; GO:0019218 regulation of steroid metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032350 regulation of hormone metabolic process; GO:0032352 positive regulation of hormone metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043009 chordate embryonic development; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045834 positive regulation of lipid metabolic process; GO:0045940 positive regulation of steroid metabolic process; GO:0045966 positive regulation of ecdysteroid metabolic process; GO:0045998 positive regulation of ecdysteroid biosynthetic process; GO:0046885 regulation of hormone biosynthetic process; GO:0046886 positive regulation of hormone biosynthetic process; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048580 regulation of post-embryonic development; GO:0048582 positive regulation of post-embryonic development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050810 regulation of steroid biosynthetic process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0062012 regulation of small molecule metabolic process; GO:0062013 positive regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090030 regulation of steroid hormone biosynthetic process; GO:0090031 positive regulation of steroid hormone biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005845 mRNA cap binding complex; GO:0032991 protein-containing complex; GO:0034518 RNA cap binding complex;","GO:0000339 RNA cap binding; GO:0000340 RNA 7-methylguanosine cap binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0019899 enzyme binding; GO:0030371 translation repressor activity; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0045182 translation regulator activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF01652","PF01652 Eukaryotic initiation factor 4E","J","KOG1669","Predicted mRNA cap-binding protein related to eIF-4E","WP4806 EGFR TYROSINE KINASE INHIBITOR RESISTANCE;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP4172 PI3KAKT SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4806_r116801;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP4172_r116400",null,"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-168256 Immune System;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1169408;https://reactome.org/PathwayBrowser/#/R-HSA-1169410;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-913531"]
["O60583","Cyclin-T2 OS=Homo sapiens OX=9606 GN=CCNT2 PE=1 SV=2","CCNT2",1.112671586,0.937180113,"nochange",591.187,821.749,534.263,755.016,1143.01,268.567,0.862251178,1.198527782,0.779227049,1.101197144,1.667089634,0.391707213,"nucleus","K15188","CCNT; cyclin T","hsa03250 Viral life cycle - HIV-1; hsa05202 Transcriptional misregulation in cancer","GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009266 response to temperature stimulus; GO:0009301 snRNA transcription; GO:0009408 response to heat; GO:0009628 response to abiotic stimulus; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0014706 striated muscle tissue development; GO:0016032 viral process; GO:0016070 RNA metabolic process; GO:0016073 snRNA metabolic process; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019080 viral gene expression; GO:0019083 viral transcription; GO:0019085 early viral transcription; GO:0019086 late viral transcription; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031440 regulation of mRNA 3'-end processing; GO:0031441 negative regulation of mRNA 3'-end processing; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0033674 positive regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0035821 modulation of process of another organism; GO:0036211 protein modification process; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042795 snRNA transcription by RNA polymerase II; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043921 modulation by host of viral transcription; GO:0043923 positive regulation by host of viral transcription; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045595 regulation of cell differentiation; GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045787 positive regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046782 regulation of viral transcription; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050434 positive regulation of viral transcription; GO:0050684 regulation of mRNA processing; GO:0050686 negative regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051147 regulation of muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051702 biological process involved in interaction with symbiont; GO:0051726 regulation of cell cycle; GO:0051851 modulation by host of symbiont process; GO:0052472 modulation by host of symbiont transcription; GO:0060255 regulation of macromolecule metabolic process; GO:0060537 muscle tissue development; GO:0060538 skeletal muscle organ development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098781 ncRNA transcription; GO:1900363 regulation of mRNA polyadenylation; GO:1900364 negative regulation of mRNA polyadenylation; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain; GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904031 positive regulation of cyclin-dependent protein kinase activity; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000307 cyclin-dependent protein kinase holoenzyme complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0008023 transcription elongation factor complex; GO:0008024 cyclin/CDK positive transcription elongation factor complex; GO:0016020 membrane; GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032783 super elongation complex; GO:0032806 carboxy-terminal domain protein kinase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0001221 transcription coregulator binding; GO:0001223 transcription coactivator binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016301 kinase activity; GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017069 snRNA binding; GO:0019207 kinase regulator activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0070063 RNA polymerase binding; GO:0097159 organic cyclic compound binding; GO:0097322 7SK snRNA binding; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;","PF00134","PF00134 Cyclin"," N-terminal domain","D","KOG0834","CDK9 kinase-activating protein cyclin T","WP4673 MALE INFERTILITY","http://www.wikipathways.org/instance/WP4673_r119920","Transcription factor","R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-162582 Signal Transduction;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167172 Transcription of the HIV genome;R-HSA-167287 HIV elongation arrest and recovery;R-HSA-167290 Pausing and recovery of HIV elongation;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-212436 Generic Transcription Pathway;R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer;R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5663205 Infectious disease;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6807505 RNA polymerase II transcribes snRNA genes;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-9006936 Signaling by TGFB family members","https://reactome.org/PathwayBrowser/#/R-HSA-112382;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-167152;https://reactome.org/PathwayBrowser/#/R-HSA-167172;https://reactome.org/PathwayBrowser/#/R-HSA-167287;https://reactome.org/PathwayBrowser/#/R-HSA-167290;https://reactome.org/PathwayBrowser/#/R-HSA-170834;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2173793;https://reactome.org/PathwayBrowser/#/R-HSA-2173796;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-674695;https://reactome.org/PathwayBrowser/#/R-HSA-6796648;https://reactome.org/PathwayBrowser/#/R-HSA-6807505;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75955;https://reactome.org/PathwayBrowser/#/R-HSA-9006936"]
["O60610","Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2","DIAPH1",1.279435579,{"v":6.25981e-05,"d":"6.26E-05"},"up",111314,111645,113598,142820,146965,140818,0.870592836,0.873181605,0.888456124,1.117002972,1.149421242,1.101345221,"nucleus","K05740","DIAPH1; diaphanous 1","hsa04510 Focal adhesion; hsa04810 Regulation of actin cytoskeleton; hsa04933 AGE-RAGE signaling pathway in diabetic complications; hsa05131 Shigellosis","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000281 mitotic cytokinesis; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0000910 cytokinesis; GO:0000912 assembly of actomyosin apparatus involved in cytokinesis; GO:0000915 actomyosin contractile ring assembly; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001775 cell activation; GO:0002064 epithelial cell development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002790 peptide secretion; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003382 epithelial cell morphogenesis; GO:0003383 apical constriction; GO:0006582 melanin metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007009 plasma membrane organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007097 nuclear migration; GO:0007110 meiosis I cytokinesis; GO:0007111 meiosis II cytokinesis; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007277 pole cell development; GO:0007279 pole cell formation; GO:0007292 female gamete generation; GO:0007338 single fertilization; GO:0007349 cellularization; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007424 open tracheal system development; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008154 actin polymerization or depolymerization; GO:0008360 regulation of cell shape; GO:0009306 protein secretion; GO:0009566 fertilization; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010256 endomembrane system organization; GO:0010522 regulation of calcium ion transport into cytosol; GO:0010638 positive regulation of organelle organization; GO:0010959 regulation of metal ion transport; GO:0014070 response to organic cyclic compound; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016476 regulation of embryonic cell shape; GO:0018958 phenol-containing compound metabolic process; GO:0019748 secondary metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022612 gland morphogenesis; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030041 actin filament polymerization; GO:0030048 actin filament-based movement; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030588 pseudocleavage; GO:0030589 pseudocleavage involved in syncytial blastoderm formation; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031032 actomyosin structure organization; GO:0031175 neuron projection development; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031532 actin cytoskeleton reorganization; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032506 cytokinetic process; GO:0032507 maintenance of protein location in cell; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033206 meiotic cytokinesis; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034776 response to histamine; GO:0035006 melanization defense response; GO:0035010 encapsulation of foreign target; GO:0035011 melanotic encapsulation of foreign target; GO:0035046 pronuclear migration; GO:0035272 exocrine system development; GO:0035372 protein localization to microtubule; GO:0036230 granulocyte activation; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042440 pigment metabolic process; GO:0042886 amide transport; GO:0043254 regulation of protein-containing complex assembly; GO:0043269 regulation of ion transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044380 protein localization to cytoskeleton; GO:0044703 multi-organism reproductive process; GO:0044837 actomyosin contractile ring organization; GO:0045010 actin nucleation; GO:0045055 regulated exocytosis; GO:0045087 innate immune response; GO:0045184 establishment of protein localization; GO:0045185 maintenance of protein location; GO:0045321 leukocyte activation; GO:0045448 mitotic cell cycle"," embryonic; GO:0045995 regulation of embryonic development; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050954 sensory perception of mechanical stimulus; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051258 protein polymerization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051279 regulation of release of sequestered calcium ion into cytosol; GO:0051282 regulation of sequestering of calcium ion; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051489 regulation of filopodium assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051647 nucleus localization; GO:0051649 establishment of localization in cell; GO:0051651 maintenance of location in cell; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051924 regulation of calcium ion transport; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060359 response to ammonium ion; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060541 respiratory system development; GO:0061024 membrane organization; GO:0061041 regulation of wound healing; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0061982 meiosis I cell cycle process; GO:0061983 meiosis II cell cycle process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070252 actin-mediated cell contraction; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071242 cellular response to ammonium ion; GO:0071310 cellular response to organic substance; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071420 cellular response to histamine; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072698 protein localization to microtubule cytoskeleton; GO:0080134 regulation of response to stress; GO:0090066 regulation of anatomical structure size; GO:0090303 positive regulation of wound healing; GO:0097320 plasma membrane tubulation; GO:0097435 supramolecular fiber organization; GO:0106036 assembly of apicomedial cortex actomyosin; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901360 organic cyclic compound metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903169 regulation of calcium ion transmembrane transport; GO:1904062 regulation of cation transmembrane transport; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005783 endoplasmic reticulum; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005903 brush border; GO:0005912 adherens junction; GO:0005938 cell cortex; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030054 cell junction; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032153 cell division site; GO:0032154 cleavage furrow; GO:0032587 ruffle membrane; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045177 apical part of cell; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0070820 tertiary granule; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098862 cluster of actin-based cell projections; GO:0099503 secretory vesicle; GO:0099568 cytoplasmic region; GO:0101002 ficolin-1-rich granule; GO:0101003 ficolin-1-rich granule membrane; GO:0120025 plasma membrane bounded cell projection;","GO:0003779 actin binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005522 profilin binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0035091 phosphatidylinositol binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044325 transmembrane transporter binding; GO:0051020 GTPase binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;",null,null,"TZ","KOG1924","RhoA GTPase effector DIA/Diaphanous","WP2324 AGERAGE PATHWAY;WP306 FOCAL ADHESION;WP524 G13 SIGNALING PATHWAY;WP2038 MICROTUBULE CYTOSKELETON REGULATION;WP51 REGULATION OF ACTIN CYTOSKELETON;WP4241 TYPE 2 PAPILLARY RENAL CELL CARCINOMA","http://www.wikipathways.org/instance/WP2324_r120674;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP524_r117113;http://www.wikipathways.org/instance/WP2038_r117173;http://www.wikipathways.org/instance/WP51_r116716;http://www.wikipathways.org/instance/WP4241_r106520",null,"R-HSA-1227986 Signaling by ERBB2;R-HSA-162582 Signal Transduction;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-6785631 ERBB2 Regulates Cell Motility;R-HSA-6798695 Neutrophil degranulation;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013405 RHOD GTPase cycle;R-HSA-9035034 RHOF GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1227986;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-6785631;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013405;https://reactome.org/PathwayBrowser/#/R-HSA-9035034;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O60613","Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4","SELENOF",0.838466776,0.060070712,"nochange",5832.68,5814.57,5258.56,4651.71,4273.6,5249.65,1.125972104,1.122476052,1.015140873,0.897991266,0.824998866,1.013420839,"extracellular",{"$nulls":3},"GO:0000003 reproduction; GO:0003006 developmental process involved in reproduction; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006457 protein folding; GO:0006458 'de novo' protein folding; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007289 spermatid nucleus differentiation; GO:0008152 metabolic process; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0019725 cellular homeostasis; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0035092 sperm DNA condensation; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0044703 multi-organism reproductive process; GO:0045454 cell redox homeostasis; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048515 spermatid differentiation; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051084 'de novo' posttranslational protein folding; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071103 DNA conformation change; GO:0071840 cellular component organization or biogenesis; GO:0097237 cellular response to toxic substance; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1990748 cellular detoxification;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004601 peroxidase activity; GO:0005488 binding; GO:0008379 thioredoxin peroxidase activity; GO:0008430 selenium binding; GO:0015036 disulfide oxidoreductase activity; GO:0016209 antioxidant activity; GO:0016491 oxidoreductase activity; GO:0016667 oxidoreductase activity"," acting on a sulfur group of donors; GO:0016684 oxidoreductase activity"," acting on peroxide as acceptor; GO:0051920 peroxiredoxin activity;","PF08806","PF08806 Sep15/SelM redox domain","R","KOG3384","Selenoprotein","WP15 SELENIUM MICRONUTRIENT NETWORK","http://www.wikipathways.org/instance/WP15_r118387"]
["O60645","Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3","EXOC3",0.713968306,0.000348105,"down",16463.9,16745.3,16479,12417.8,11839.8,11218.2,1.159919684,1.179744963,1.160983514,0.874862618,0.834141186,0.790348034,"cytoplasm","K06110",null,null,"GO:0000003 reproduction; GO:0001505 regulation of neurotransmitter levels; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006893 Golgi to plasma membrane transport; GO:0006903 vesicle targeting; GO:0006904 vesicle docking involved in exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007009 plasma membrane organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010631 epithelial cell migration; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016079 synaptic vesicle exocytosis; GO:0016080 synaptic vesicle targeting; GO:0016081 synaptic vesicle docking; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016477 cell migration; GO:0017156 calcium-ion regulated exocytosis; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022406 membrane docking; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0023061 signal release; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031503 protein-containing complex localization; GO:0032456 endocytic recycling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0040011 locomotion; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0042886 amide transport; GO:0043001 Golgi to plasma membrane protein transport; GO:0044085 cellular component biogenesis; GO:0044091 membrane biogenesis; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045313 rhabdomere membrane biogenesis; GO:0046530 photoreceptor cell differentiation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048278 vesicle docking; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048592 eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051601 exocyst localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0060429 epithelium development; GO:0061024 membrane organization; GO:0061951 establishment of protein localization to plasma membrane; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0072697 protein localization to cell cortex; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090150 establishment of protein localization to membrane; GO:0090596 sensory organ morphogenesis; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098876 vesicle-mediated transport to the plasma membrane; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering; GO:1990778 protein localization to cell periphery;","GO:0000145 exocyst; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0005915 zonula adherens; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016028 rhabdomere; GO:0030054 cell junction; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043296 apical junction complex; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0099023 vesicle tethering complex; GO:0099503 secretory vesicle; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0000149 SNARE binding; GO:0005488 binding; GO:0005515 protein binding;",null,null,"U","KOG2286","Exocyst complex subunit SEC6","WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP4352_r102218",null,"R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-199991 Membrane Trafficking;R-HSA-264876 Insulin processing;R-HSA-2980736 Peptide hormone metabolism;R-HSA-392499 Metabolism of proteins;R-HSA-5617833 Cilium Assembly;R-HSA-5620916 VxPx cargo-targeting to cilium;R-HSA-5620920 Cargo trafficking to the periciliary membrane;R-HSA-5653656 Vesicle-mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-1445148;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-264876;https://reactome.org/PathwayBrowser/#/R-HSA-2980736;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620916;https://reactome.org/PathwayBrowser/#/R-HSA-5620920;https://reactome.org/PathwayBrowser/#/R-HSA-5653656"]
["O60664","Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3","PLIN3",1.259830976,0.000463306,"up",175553,183484,173667,222056,219208,229853,0.874978921,0.914508054,0.865578853,1.106755905,1.092561103,1.145617164,"cytoplasm","K20287",null,null,"GO:0006810 transport; GO:0016192 vesicle-mediated transport; GO:0051179 localization; GO:0051234 establishment of localization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005811 lipid droplet; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0097708 intracellular vesicle;",{"$nulls":9},"R-HSA-1430728 Metabolism;R-HSA-162582 Signal Transduction;R-HSA-1632852 Macroautophagy;R-HSA-163560 Triglyceride catabolism;R-HSA-199991 Membrane Trafficking;R-HSA-556833 Metabolism of lipids;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8979227 Triglyceride metabolism;R-HSA-9612973 Autophagy;R-HSA-9613354 Lipophagy;R-HSA-9613829 Chaperone Mediated Autophagy;R-HSA-9615710 Late endosomal microautophagy;R-HSA-9663891 Selective autophagy;R-HSA-9706019 RHOBTB3 ATPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-163560;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8979227;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9613354;https://reactome.org/PathwayBrowser/#/R-HSA-9613829;https://reactome.org/PathwayBrowser/#/R-HSA-9615710;https://reactome.org/PathwayBrowser/#/R-HSA-9663891;https://reactome.org/PathwayBrowser/#/R-HSA-9706019;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O60671","Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1","RAD1",0.946014307,0.815741397,"nochange",8184,12310.1,13111.1,9668.69,9567.81,12554.5,0.750869317,1.129432597,1.202923106,0.887087323,0.877831739,1.151855918,"cytoskeleton","K02830","HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]","hsa04218 Cellular senescence","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000723 telomere maintenance; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006278 RNA-dependent DNA biosynthetic process; GO:0006281 DNA repair; GO:0006289 nucleotide-excision repair; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007004 telomere maintenance via telomerase; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0010212 response to ionizing radiation; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010833 telomere maintenance via telomere lengthening; GO:0010948 negative regulation of cell cycle process; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0023052 signaling; GO:0031570 DNA integrity checkpoint signaling; GO:0032200 telomere organization; GO:0033043 regulation of organelle organization; GO:0033313 meiotic cell cycle checkpoint signaling; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035556 intracellular signal transduction; GO:0040020 regulation of meiotic nuclear division; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045786 negative regulation of cell cycle; GO:0045835 negative regulation of meiotic nuclear division; GO:0046483 heterocycle metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051445 regulation of meiotic cell cycle; GO:0051447 negative regulation of meiotic cell cycle; GO:0051598 meiotic recombination checkpoint signaling; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0060249 anatomical structure homeostasis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0104004 cellular response to environmental stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903046 meiotic cell cycle process; GO:2000241 regulation of reproductive process; GO:2000242 negative regulation of reproductive process;","GO:0000228 nuclear chromosome; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0030896 checkpoint clamp complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004527 exonuclease activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008408 3'-5' exonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"DL","KOG3194","Checkpoint 9-1-1 complex"," RAD1 component","WP3875 ATR SIGNALING;WP707 DNA DAMAGE RESPONSE;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR;WP1530 MIRNA REGULATION OF DNA DAMAGE RESPONSE","http://www.wikipathways.org/instance/WP3875_r117657;http://www.wikipathways.org/instance/WP707_r116541;http://www.wikipathways.org/instance/WP4016_r120667;http://www.wikipathways.org/instance/WP1530_r118120",null,"R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-176187 Activation of ATR in response to replication stress;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5685938 HDR through Single Strand Annealing (SSA);R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-9675135 Diseases of DNA repair;R-HSA-9675136 Diseases of DNA Double-Strand Break Repair;R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function;R-HSA-9709570 Impaired BRCA2 binding to RAD51","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-176187;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5633007;https://reactome.org/PathwayBrowser/#/R-HSA-5685938;https://reactome.org/PathwayBrowser/#/R-HSA-5685942;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693538;https://reactome.org/PathwayBrowser/#/R-HSA-5693567;https://reactome.org/PathwayBrowser/#/R-HSA-5693579;https://reactome.org/PathwayBrowser/#/R-HSA-5693607;https://reactome.org/PathwayBrowser/#/R-HSA-5693616;https://reactome.org/PathwayBrowser/#/R-HSA-6804756;https://reactome.org/PathwayBrowser/#/R-HSA-69473;https://reactome.org/PathwayBrowser/#/R-HSA-69481;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-9675135;https://reactome.org/PathwayBrowser/#/R-HSA-9675136;https://reactome.org/PathwayBrowser/#/R-HSA-9701190;https://reactome.org/PathwayBrowser/#/R-HSA-9709570","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["O60674","Tyrosine-protein kinase JAK2 OS=Homo sapiens OX=9606 GN=JAK2 PE=1 SV=2","JAK2",1.140543938,0.353640161,"nochange",2767.56,3869.77,3927.48,4563.66,3645.7,3840.27,0.734281282,1.026716558,1.042028014,1.210817513,0.967266932,1.018889701,"cytoplasm","K04447","JAK2; Janus kinase 2 [EC:2.7.10.2]","hsa04725 Cholinergic synapse; hsa01521 EGFR tyrosine kinase inhibitor resistance; hsa05161 Hepatitis B; hsa05200 Pathways in cancer; hsa04935 Growth hormone synthesis"," secretion and action; hsa05207 Chemical carcinogenesis - receptor activation; hsa04917 Prolactin signaling pathway; hsa05168 Herpes simplex virus 1 infection; hsa05145 Toxoplasmosis; hsa04630 JAK-STAT signaling pathway; hsa04062 Chemokine signaling pathway; hsa05152 Tuberculosis; hsa05140 Leishmaniasis; hsa04658 Th1 and Th2 cell differentiation; hsa05164 Influenza A; hsa04659 Th17 cell differentiation; hsa04550 Signaling pathways regulating pluripotency of stem cells; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04920 Adipocytokine signaling pathway; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa04151 PI3K-Akt signaling pathway; hsa05417 Lipid and atherosclerosis; hsa04217 Necroptosis; hsa04933 AGE-RAGE signaling pathway in diabetic complications","GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001505 regulation of neurotransmitter levels; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001672 regulation of chromatin assembly or disassembly; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001775 cell activation; GO:0001776 leukocyte homeostasis; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002237 response to molecule of bacterial origin; GO:0002252 immune effector process; GO:0002260 lymphocyte homeostasis; GO:0002262 myeloid cell homeostasis; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002698 negative regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002701 negative regulation of production of molecular mediator of immune response; GO:0002703 regulation of leukocyte mediated immunity; GO:0002704 negative regulation of leukocyte mediated immunity; GO:0002718 regulation of cytokine production involved in immune response; GO:0002719 negative regulation of cytokine production involved in immune response; GO:0002730 regulation of dendritic cell cytokine production; GO:0002731 negative regulation of dendritic cell cytokine production; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0002819 regulation of adaptive immune response; GO:0002820 negative regulation of adaptive immune response; GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002825 regulation of T-helper 1 type immune response; GO:0002826 negative regulation of T-helper 1 type immune response; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003382 epithelial cell morphogenesis; GO:0003383 apical constriction; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006915 apoptotic process; GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007259 receptor signaling pathway via JAK-STAT; GO:0007260 tyrosine phosphorylation of STAT protein; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007350 blastoderm segmentation; GO:0007365 periodic partitioning; GO:0007369 gastrulation; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007442 hindgut morphogenesis; GO:0007444 imaginal disc development; GO:0007455 eye-antennal disc morphogenesis; GO:0007498 mesoderm development; GO:0007530 sex determination; GO:0007538 primary sex determination; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0007622 rhythmic behavior; GO:0007623 circadian rhythm; GO:0007626 locomotory behavior; GO:0008016 regulation of heart contraction; GO:0008152 metabolic process; GO:0008154 actin polymerization or depolymerization; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008360 regulation of cell shape; GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009611 response to wounding; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009880 embryonic pattern specification; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010561 negative regulation of glycoprotein biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010656 negative regulation of muscle cell apoptotic process; GO:0010660 regulation of muscle cell apoptotic process; GO:0010662 regulation of striated muscle cell apoptotic process; GO:0010664 negative regulation of striated muscle cell apoptotic process; GO:0010665 regulation of cardiac muscle cell apoptotic process; GO:0010667 negative regulation of cardiac muscle cell apoptotic process; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0010817 regulation of hormone levels; GO:0010847 regulation of chromatin assembly; GO:0010921 regulation of phosphatase activity; GO:0010922 positive regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling; GO:0014070 response to organic cyclic compound; GO:0014842 regulation of skeletal muscle satellite cell proliferation; GO:0014857 regulation of skeletal muscle cell proliferation; GO:0014858 positive regulation of skeletal muscle cell proliferation; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016318 ommatidial rotation; GO:0016476 regulation of embryonic cell shape; GO:0016477 cell migration; GO:0016570 histone modification; GO:0016572 histone phosphorylation; GO:0017145 stem cell division; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030003 cellular cation homeostasis; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030041 actin filament polymerization; GO:0030048 actin filament-based movement; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030162 regulation of proteolysis; GO:0030182 neuron differentiation; GO:0030183 B cell differentiation; GO:0030218 erythrocyte differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0030707 ovarian follicle cell development; GO:0030713 ovarian follicle cell stalk formation; GO:0030855 epithelial cell differentiation; GO:0030879 mammary gland development; GO:0031099 regeneration; GO:0031102 neuron projection regeneration; GO:0031103 axon regeneration; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031445 regulation of heterochromatin assembly; GO:0031453 positive regulation of heterochromatin assembly; GO:0031958 corticosteroid receptor signaling pathway; GO:0031959 mineralocorticoid receptor signaling pathway; GO:0031960 response to corticosteroid; GO:0032024 positive regulation of insulin secretion; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032516 positive regulation of phosphoprotein phosphatase activity; GO:0032651 regulation of interleukin-1 beta production; GO:0032652 regulation of interleukin-1 production; GO:0032653 regulation of interleukin-10 production; GO:0032655 regulation of interleukin-12 production; GO:0032680 regulation of tumor necrosis factor production; GO:0032693 negative regulation of interleukin-10 production; GO:0032695 negative regulation of interleukin-12 production; GO:0032731 positive regulation of interleukin-1 beta production; GO:0032732 positive regulation of interleukin-1 production; GO:0032760 positive regulation of tumor necrosis factor production; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032944 regulation of mononuclear cell proliferation; GO:0032946 positive regulation of mononuclear cell proliferation; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033157 regulation of intracellular protein transport; GO:0033194 response to hydroperoxide; GO:0033209 tumor necrosis factor-mediated signaling pathway; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0033993 response to lipid; GO:0034050 programmed cell death induced by symbiont; GO:0034097 response to cytokine; GO:0034101 erythrocyte homeostasis; GO:0034340 response to type I interferon; GO:0034341 response to interferon-gamma; GO:0034599 cellular response to oxidative stress; GO:0034612 response to tumor necrosis factor; GO:0035166 post-embryonic hemopoiesis; GO:0035167 larval lymph gland hemopoiesis; GO:0035168 larval lymph gland hemocyte differentiation; GO:0035171 lamellocyte differentiation; GO:0035172 hemocyte proliferation; GO:0035206 regulation of hemocyte proliferation; GO:0035214 eye-antennal disc development; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035295 tube development; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035306 positive regulation of dephosphorylation; GO:0035307 positive regulation of protein dephosphorylation; GO:0035406 histone-tyrosine phosphorylation; GO:0035409 histone H3-Y41 phosphorylation; GO:0035556 intracellular signal transduction; GO:0035722 interleukin-12-mediated signaling pathway; GO:0035723 interleukin-15-mediated signaling pathway; GO:0035771 interleukin-4-mediated signaling pathway; GO:0036015 response to interleukin-3; GO:0036016 cellular response to interleukin-3; GO:0036211 protein modification process; GO:0036473 cell death in response to oxidative stress; GO:0038083 peptidyl-tyrosine autophosphorylation; GO:0038110 interleukin-2-mediated signaling pathway; GO:0038111 interleukin-7-mediated signaling pathway; GO:0038113 interleukin-9-mediated signaling pathway; GO:0038114 interleukin-21-mediated signaling pathway; GO:0038155 interleukin-23-mediated signaling pathway; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042060 wound healing; GO:0042067 establishment of ommatidial planar polarity; GO:0042074 cell migration involved in gastrulation; GO:0042078 germ-line stem cell division; GO:0042102 positive regulation of T cell proliferation; GO:0042113 B cell activation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042386 hemocyte differentiation; GO:0042387 plasmatocyte differentiation; GO:0042509 regulation of tyrosine phosphorylation of STAT protein; GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein; GO:0042592 homeostatic process; GO:0042976 activation of Janus kinase activity; GO:0042981 regulation of apoptotic process; GO:0043029 T cell homeostasis; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043370 regulation of CD4-positive"," alpha-beta T cell differentiation; GO:0043371 negative regulation of CD4-positive"," alpha-beta T cell differentiation; GO:0043388 positive regulation of DNA binding; GO:0043392 negative regulation of DNA binding; GO:0043401 steroid hormone mediated signaling pathway; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043549 regulation of kinase activity; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045219 regulation of FasL production; GO:0045221 negative regulation of FasL production; GO:0045317 equator specification; GO:0045321 leukocyte activation; GO:0045428 regulation of nitric oxide biosynthetic process; GO:0045429 positive regulation of nitric oxide biosynthetic process; GO:0045475 locomotor rhythm; GO:0045580 regulation of T cell differentiation; GO:0045581 negative regulation of T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045610 regulation of hemocyte differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045620 negative regulation of lymphocyte differentiation; GO:0045622 regulation of T-helper cell differentiation; GO:0045623 negative regulation of T-helper cell differentiation; GO:0045625 regulation of T-helper 1 cell differentiation; GO:0045626 negative regulation of T-helper 1 cell differentiation; GO:0045765 regulation of angiogenesis; GO:0045766 positive regulation of angiogenesis; GO:0045785 positive regulation of cell adhesion; GO:0045799 positive regulation of chromatin assembly or disassembly; GO:0045822 negative regulation of heart contraction; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045862 positive regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045995 regulation of embryonic development; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT; GO:0046530 photoreceptor cell differentiation; GO:0046634 regulation of alpha-beta T cell activation; GO:0046636 negative regulation of alpha-beta T cell activation; GO:0046637 regulation of alpha-beta T cell differentiation; GO:0046639 negative regulation of alpha-beta T cell differentiation; GO:0046649 lymphocyte activation; GO:0046677 response to antibiotic; GO:0046777 protein autophosphorylation; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0048008 platelet-derived growth factor receptor signaling pathway; GO:0048103 somatic stem cell division; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048511 rhythmic process; GO:0048512 circadian behavior; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048542 lymph gland development; GO:0048545 response to steroid hormone; GO:0048546 digestive tract morphogenesis; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048565 digestive tract development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0048666 neuron development; GO:0048678 response to axon injury; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048859 formation of anatomical boundary; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048872 homeostasis of number of cells; GO:0048878 chemical homeostasis; GO:0050670 regulation of lymphocyte proliferation; GO:0050671 positive regulation of lymphocyte proliferation; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050727 regulation of inflammatory response; GO:0050729 positive regulation of inflammatory response; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050801 ion homeostasis; GO:0050817 coagulation; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050868 negative regulation of T cell activation; GO:0050870 positive regulation of T cell activation; GO:0050877 nervous system process; GO:0050878 regulation of body fluid levels; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051100 negative regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051250 negative regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051258 protein polymerization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051384 response to glucocorticoid; GO:0051480 regulation of cytosolic calcium ion concentration; GO:0051607 defense response to virus; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051769 regulation of nitric-oxide synthase biosynthetic process; GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055123 digestive system development; GO:0060026 convergent extension; GO:0060027 convergent extension involved in gastrulation; GO:0060031 mediolateral intercalation; GO:0060255 regulation of macromolecule metabolic process; GO:0060330 regulation of response to interferon-gamma; GO:0060333 interferon-gamma-mediated signaling pathway; GO:0060334 regulation of interferon-gamma-mediated signaling pathway; GO:0060337 type I interferon signaling pathway; GO:0060341 regulation of cellular localization; GO:0060396 growth hormone receptor signaling pathway; GO:0060397 growth hormone receptor signaling pathway via JAK-STAT; GO:0060398 regulation of growth hormone receptor signaling pathway; GO:0060399 positive regulation of growth hormone receptor signaling pathway; GO:0060416 response to growth hormone; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060759 regulation of response to cytokine stimulus; GO:0061180 mammary gland epithelium development; GO:0061525 hindgut development; GO:0061564 axon development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070102 interleukin-6-mediated signaling pathway; GO:0070106 interleukin-27-mediated signaling pathway; GO:0070201 regulation of establishment of protein localization; GO:0070228 regulation of lymphocyte apoptotic process; GO:0070229 negative regulation of lymphocyte apoptotic process; GO:0070232 regulation of T cell apoptotic process; GO:0070233 negative regulation of T cell apoptotic process; GO:0070243 regulation of thymocyte apoptotic process; GO:0070244 negative regulation of thymocyte apoptotic process; GO:0070252 actin-mediated cell contraction; GO:0070663 regulation of leukocyte proliferation; GO:0070665 positive regulation of leukocyte proliferation; GO:0070669 response to interleukin-2; GO:0070670 response to interleukin-4; GO:0070671 response to interleukin-12; GO:0070672 response to interleukin-15; GO:0070741 response to interleukin-6; GO:0070757 interleukin-35-mediated signaling pathway; GO:0070887 cellular response to chemical stimulus; GO:0071104 response to interleukin-9; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0071349 cellular response to interleukin-12; GO:0071350 cellular response to interleukin-15; GO:0071352 cellular response to interleukin-2; GO:0071353 cellular response to interleukin-4; GO:0071354 cellular response to interleukin-6; GO:0071355 cellular response to interleukin-9; GO:0071356 cellular response to tumor necrosis factor; GO:0071357 cellular response to type I interferon; GO:0071375 cellular response to peptide hormone stimulus; GO:0071378 cellular response to growth hormone stimulus; GO:0071383 cellular response to steroid hormone stimulus; GO:0071384 cellular response to corticosteroid stimulus; GO:0071385 cellular response to glucocorticoid stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071466 cellular response to xenobiotic stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071548 response to dexamethasone; GO:0071549 cellular response to dexamethasone stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:0090316 positive regulation of intracellular protein transport; GO:0090596 sensory organ morphogenesis; GO:0097012 response to granulocyte macrophage colony-stimulating factor; GO:0097190 apoptotic signaling pathway; GO:0097191 extrinsic apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097296 activation of cysteine-type endopep","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005901 caveola; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016363 nuclear matrix; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031904 endosome lumen; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044853 plasma membrane raft; GO:0045121 membrane raft; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098590 plasma membrane region; GO:0098857 membrane microdomain;","GO:0001664 G protein-coupled receptor binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004715 non-membrane spanning protein tyrosine kinase activity; GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005131 growth hormone receptor binding; GO:0005143 interleukin-12 receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0019904 protein domain specific binding; GO:0020037 heme binding; GO:0031267 small GTPase binding; GO:0031625 ubiquitin protein ligase binding; GO:0031701 angiotensin receptor binding; GO:0031702 type 1 angiotensin receptor binding; GO:0033130 acetylcholine receptor binding; GO:0035173 histone kinase activity; GO:0035400 histone tyrosine kinase activity; GO:0035401 histone kinase activity (H3-Y41 specific); GO:0042169 SH2 domain binding; GO:0042393 histone binding; GO:0042802 identical protein binding; GO:0043548 phosphatidylinositol 3-kinase binding; GO:0043560 insulin receptor substrate binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0046906 tetrapyrrole binding; GO:0051020 GTPase binding; GO:0051427 hormone receptor binding; GO:0051428 peptide hormone receptor binding; GO:0070851 growth factor receptor binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;","PF18379; PF18377; PF17887; PF00017; PF07714","PF18379 FERM F1 ubiquitin-like domain; PF18377 FERM F2 acyl-CoA binding protein-like domain; PF17887 Jak1 pleckstrin homology-like domain; PF00017 SH2 domain; PF07714 Protein tyrosine and serine/threonine kinase","T","KOG0197","Tyrosine kinases","WP4950 16P112 DISTAL DELETION SYNDROME;WP2324 AGERAGE PATHWAY;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP3929 CHEMOKINE SIGNALING PATHWAY;WP437 EGFEGFR SIGNALING PATHWAY;WP4806 EGFR TYROSINE KINASE INHIBITOR RESISTANCE;WP581 EPO RECEPTOR SIGNALING;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP4666 HEPATITIS B INFECTION;WP2112 IL17 SIGNALING PATHWAY;WP286 IL3 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP127 IL5 SIGNALING PATHWAY;WP364 IL6 SIGNALING PATHWAY;WP4197 IMMUNE RESPONSE TO TUBERCULOSIS;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP2034 LEPTIN SIGNALING PATHWAY;WP3935 LEPTININSULIN SIGNALING OVERLAP;WP2817 MAMMARY GLAND DEVELOPMENT PATHWAY PREGNANCY AND LACTATION STAGE 3 OF 4;WP4829 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION;WP2857 MESODERMAL COMMITMENT PATHWAY;WP4337 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA;WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY;WP61 NOTCH SIGNALING PATHWAY;WP2374 ONCOSTATIN M SIGNALING PATHWAY;WP4558 OVERVIEW OF INTERFERONSMEDIATED SIGNALING PATHWAY;WP3972 PDGFRBETA PATHWAY;WP4172 PI3KAKT SIGNALING PATHWAY;WP2037 PROLACTIN SIGNALING PATHWAY;WP4538 REGULATORY CIRCUITS OF THE STAT3 SIGNALING PATHWAY;WP5098 TCELL ACTIVATION SARSCOV2;WP2203 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING PATHWAY;WP2032 THYROID STIMULATING HORMONE TSH SIGNALING PATHWAY;WP619 TYPE II INTERFERON SIGNALING IFNG","http://www.wikipathways.org/instance/WP4950_r115784;http://www.wikipathways.org/instance/WP2324_r120674;http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP3929_r119247;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP4806_r116801;http://www.wikipathways.org/instance/WP581_r117099;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP2112_r117960;http://www.wikipathways.org/instance/WP286_r120663;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP127_r120669;http://www.wikipathways.org/instance/WP364_r120715;http://www.wikipathways.org/instance/WP4197_r120647;http://www.wikipathways.org/instance/WP2332_r120725;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP2034_r120670;http://www.wikipathways.org/instance/WP3935_r118425;http://www.wikipathways.org/instance/WP2817_r102410;http://www.wikipathways.org/instance/WP4829_r109219;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP4337_r108190;http://www.wikipathways.org/instance/WP5115_r120597;http://www.wikipathways.org/instance/WP61_r120637;http://www.wikipathways.org/instance/WP2374_r120781;http://www.wikipathways.org/instance/WP4558_r107928;http://www.wikipathways.org/instance/WP3972_r108157;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP2037_r116779;http://www.wikipathways.org/instance/WP4538_r104390;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP2203_r120724;http://www.wikipathways.org/instance/WP2032_r120723;http://www.wikipathways.org/instance/WP619_r106442",null,"R-HSA-1059683 Interleukin-6 signaling;R-HSA-109582 Hemostasis;R-HSA-110056 MAPK3 (ERK1) activation;R-HSA-112409 RAF-independent MAPK1/3 activation;R-HSA-112411 MAPK1 (ERK2) activation;R-HSA-1170546 Prolactin receptor signaling;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1433557 Signaling by SCF-KIT;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-2586552 Signaling by Leptin;R-HSA-3214858 RMTs methylate histone arginines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-447115 Interleukin-12 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-451927 Interleukin-2 family signaling;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4839726 Chromatin organization;R-HSA-512988 Interleukin-3"," Interleukin-5 and GM-CSF signaling;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5673000 RAF activation;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6783589 Interleukin-6 family signaling;R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling;R-HSA-6788467 IL-6-type cytokine receptor ligand interactions;R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants;R-HSA-6802949 Signaling by RAS mutants;R-HSA-6802952 Signaling by BRAF and RAF1 fusions;R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF;R-HSA-6802957 Oncogenic MAPK signaling;R-HSA-69231 Cyclin D associated events in G1;R-HSA-69236 G1 Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-877300 Interferon gamma signaling;R-HSA-877312 Regulation of IFNG signaling;R-HSA-8854691 Interleukin-20 family signaling;R-HSA-8984722 Interleukin-35 Signalling;R-HSA-9006335 Signaling by Erythropoietin;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9020591 Interleukin-12 signaling;R-HSA-9020933 Interleukin-23 signaling;R-HSA-9020956 Interleukin-27 signaling;R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K);R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG);R-HSA-9027283 Erythropoietin activates STAT5;R-HSA-9027284 Erythropoietin activates RAS;R-HSA-912526 Interleukin receptor SHC signaling;R-HSA-913531 Interferon Signaling;R-HSA-9649948 Signaling downstream of RAS mutants;R-HSA-9656223 Signaling by RAF1 mutants;R-HSA-9669938 Signaling by KIT in disease;R-HSA-9670439 Signaling by phosphorylated juxtamembrane"," extracellular and kinase domain KIT mutants;R-HSA-9674555 Signaling by CSF3 (G-CSF);R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections;R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling;R-HSA-982772 Growth hormone receptor signaling;R-HSA-983231 Factors involved in megakaryocyte development and platelet production",null,"ALLOGRAFT REJECTION;COMPLEMENT;ESTROGEN RESPONSE EARLY;ESTROGEN RESPONSE LATE;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["O60678","Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4","PRMT3",0.474438101,{"v":1.75718E-5,"d":"1.76E-05"},"down",23715.2,23150.1,21461,10835.2,10662.1,10919.3,1.412419138,1.378763168,1.278164516,0.645317933,0.635008522,0.650326723,"nucleus","K11436",null,null,"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0018193 peptidyl-amino acid modification; GO:0018195 peptidyl-arginine modification; GO:0018216 peptidyl-arginine methylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019919 peptidyl-arginine methylation"," to asymmetrical-dimethyl arginine; GO:0022008 neurogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0034969 histone arginine methylation; GO:0035246 peptidyl-arginine N-methylation; GO:0035247 peptidyl-arginine omega-N-methylation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048468 cell development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060996 dendritic spine development; GO:0060997 dendritic spine morphogenesis; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0097061 dendritic spine organization; GO:0099173 postsynapse organization; GO:0106027 neuron projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901564 organonitrogen compound metabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008469 histone-arginine N-methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016273 arginine N-methyltransferase activity; GO:0016274 protein-arginine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity; GO:0042054 histone methyltransferase activity; GO:0072341 modified amino acid binding; GO:0140096 catalytic activity"," acting on a protein;",null,null,"OKT","KOG1499","Protein arginine N-methyltransferase PRMT1 and related enzymes","WP4947 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS","http://www.wikipathways.org/instance/WP4947_r118070",null,"R-HSA-3214858 RMTs methylate histone arginines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-392499 Metabolism of proteins;R-HSA-4839726 Chromatin organization;R-HSA-597592 Post-translational protein modification;R-HSA-8876725 Protein methylation","https://reactome.org/PathwayBrowser/#/R-HSA-3214858;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8876725","MYC TARGETS V2","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2"]
["O60683","Peroxisome biogenesis factor 10 OS=Homo sapiens OX=9606 GN=PEX10 PE=1 SV=1","PEX10",0.766785016,0.071159561,"nochange",4902.79,4291.44,4657.41,3666.12,2862.08,4093.03,1.202014312,1.052129971,1.141854633,0.898820612,0.70169457,1.003485901,"nucleus","K13346","PEX10; peroxin-10","hsa04146 Peroxisome","GO:0000003 reproduction; GO:0000038 very long-chain fatty acid metabolic process; GO:0000280 nuclear division; GO:0000910 cytokinesis; GO:0003006 developmental process involved in reproduction; GO:0006082 organic acid metabolic process; GO:0006464 cellular protein modification process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0007049 cell cycle; GO:0007112 male meiosis cytokinesis; GO:0007140 male meiotic nuclear division; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007285 primary spermatocyte growth; GO:0007286 spermatid development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015919 peroxisomal membrane transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016054 organic acid catabolic process; GO:0016558 protein import into peroxisome matrix; GO:0016567 protein ubiquitination; GO:0017038 protein import; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0033206 meiotic cytokinesis; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0040007 growth; GO:0042760 very long-chain fatty acid catabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044703 multi-organism reproductive process; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045184 establishment of protein localization; GO:0046395 carboxylic acid catabolic process; GO:0046907 intracellular transport; GO:0048137 spermatocyte division; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048515 spermatid differentiation; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065002 intracellular protein transmembrane transport; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0140013 meiotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process; GO:1903046 meiotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005779 integral component of peroxisomal membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031231 intrinsic component of peroxisomal membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031903 microbody membrane; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0140096 catalytic activity"," acting on a protein;","PF13920","PF13920 Zinc finger"," C3HC4 type (RING finger)","O","KOG0317","Predicted E3 ubiquitin ligase"," integral peroxisomal membrane protein","WP4673 MALE INFERTILITY","http://www.wikipathways.org/instance/WP4673_r119920",null,"R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507"]
["O60684","Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1","KPNA6",0.834974874,0.005410629,"down",86268.6,86794.4,80083.3,67804.6,72678.3,70887.9,1.114300421,1.12109199,1.034407129,0.875807586,0.938759413,0.915633461,"cytoplasm","nucleus","K15042","KPNA5_6; importin subunit alpha-6/7","hsa03013 Nucleocytoplasmic transport; hsa05164 Influenza A; hsa05207 Chemical carcinogenesis - receptor activation","GO:0000003 reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007565 female pregnancy; GO:0008104 protein localization; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0017038 protein import; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045184 establishment of protein localization; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046907 intracellular transport; GO:0048232 male gamete generation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060135 maternal process involved in female pregnancy; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005048 signal sequence binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008139 nuclear localization sequence binding; GO:0033218 amide binding; GO:0042277 peptide binding;",null,null,"U","KOG0166","Karyopherin (importin) alpha",{"$nulls":3},"R-HSA-68616 Assembly of the ORC complex at the origin of replication;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69306 DNA Replication","https://reactome.org/PathwayBrowser/#/R-HSA-68616;https://reactome.org/PathwayBrowser/#/R-HSA-68867;https://reactome.org/PathwayBrowser/#/R-HSA-69002;https://reactome.org/PathwayBrowser/#/R-HSA-69306"]
["O60701","UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1","UGDH",1.264448718,0.001019024,"up",22055.4,23747.6,22464.3,29593,27993.3,28734.2,0.856033917,0.921713098,0.87190451,1.148589992,1.086501005,1.115257478,"cytoplasm","K00012","UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]","hsa01250 Biosynthesis of nucleotide sugars; hsa01240 Biosynthesis of cofactors; hsa00053 Ascorbate and aldarate metabolism; hsa00520 Amino sugar and nucleotide sugar metabolism; hsa00040 Pentose and glucuronate interconversions; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000271 polysaccharide biosynthetic process; GO:0001667 ameboidal-type cell migration; GO:0001702 gastrulation with mouth forming second; GO:0001704 formation of primary germ layer; GO:0001707 mesoderm formation; GO:0001763 morphogenesis of a branching structure; GO:0002009 morphogenesis of an epithelium; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003002 regionalization; GO:0005975 carbohydrate metabolic process; GO:0005976 polysaccharide metabolic process; GO:0006011 UDP-glucose metabolic process; GO:0006022 aminoglycan metabolic process; GO:0006023 aminoglycan biosynthetic process; GO:0006024 glycosaminoglycan biosynthetic process; GO:0006029 proteoglycan metabolic process; GO:0006065 UDP-glucuronate biosynthetic process; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007350 blastoderm segmentation; GO:0007365 periodic partitioning; GO:0007367 segment polarity determination; GO:0007369 gastrulation; GO:0007389 pattern specification process; GO:0007424 open tracheal system development; GO:0007427 epithelial cell migration"," open tracheal system; GO:0007428 primary branching"," open tracheal system; GO:0007498 mesoderm development; GO:0007509 mesoderm migration involved in gastrulation; GO:0007610 behavior; GO:0008078 mesodermal cell migration; GO:0008152 metabolic process; GO:0008543 fibroblast growth factor receptor signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009226 nucleotide-sugar biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009880 embryonic pattern specification; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010631 epithelial cell migration; GO:0015012 heparan sulfate proteoglycan biosynthetic process; GO:0015014 heparan sulfate proteoglycan biosynthetic process"," polysaccharide chain biosynthetic process; GO:0016051 carbohydrate biosynthetic process; GO:0016053 organic acid biosynthetic process; GO:0016477 cell migration; GO:0018130 heterocycle biosynthetic process; GO:0018991 oviposition; GO:0019098 reproductive behavior; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022414 reproductive process; GO:0022900 electron transport chain; GO:0023052 signaling; GO:0030166 proteoglycan biosynthetic process; GO:0030201 heparan sulfate proteoglycan metabolic process; GO:0030203 glycosaminoglycan metabolic process; GO:0030204 chondroitin sulfate metabolic process; GO:0030206 chondroitin sulfate biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033692 cellular polysaccharide biosynthetic process; GO:0034637 cellular carbohydrate biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035295 tube development; GO:0040011 locomotion; GO:0040025 vulval development; GO:0042074 cell migration involved in gastrulation; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044264 cellular polysaccharide metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0046394 carboxylic acid biosynthetic process; GO:0046398 UDP-glucuronate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048332 mesoderm morphogenesis; GO:0048513 animal organ development; GO:0048569 post-embryonic animal organ development; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050650 chondroitin sulfate proteoglycan biosynthetic process; GO:0050654 chondroitin sulfate proteoglycan metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060429 epithelium development; GO:0060446 branching involved in open tracheal system development; GO:0060541 respiratory system development; GO:0060562 epithelial tube morphogenesis; GO:0061138 morphogenesis of a branching epithelium; GO:0065007 biological regulation; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071774 response to fibroblast growth factor; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903510 mucopolysaccharide metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0003979 UDP-glucose 6-dehydrogenase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor; GO:0042802 identical protein binding;","PF03721; PF00984; PF03720","PF03721 UDP-glucose/GDP-mannose dehydrogenase family"," NAD binding domain; PF00984 UDP-glucose/GDP-mannose dehydrogenase family"," central domain; PF03720 UDP-glucose/GDP-mannose dehydrogenase family"," UDP binding domain","GT","KOG2666","UDP-glucose/GDP-mannose dehydrogenase","WP698 GLUCURONIDATION","http://www.wikipathways.org/instance/WP698_r106827",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156588 Glucuronidation;R-HSA-173599 Formation of the active cofactor"," UDP-glucuronate;R-HSA-211859 Biological oxidations","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156588;https://reactome.org/PathwayBrowser/#/R-HSA-173599;https://reactome.org/PathwayBrowser/#/R-HSA-211859","ESTROGEN RESPONSE LATE;FATTY ACID METABOLISM;XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["O60704","Protein-tyrosine sulfotransferase 2 OS=Homo sapiens OX=9606 GN=TPST2 PE=1 SV=1","TPST2",1.414602434,0.108621586,"nochange",7318.64,4999.7,5363.37,6605.13,10028.9,8378.56,1.028517624,0.702627751,0.753735745,0.928245222,1.409401255,1.177472403,"Golgi apparatus","K01021",null,null,"GO:0000003 reproduction; GO:0001775 cell activation; GO:0002790 peptide secretion; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006464 cellular protein modification process; GO:0006477 protein sulfation; GO:0006478 peptidyl-tyrosine sulfation; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0007275 multicellular organism development; GO:0007338 single fertilization; GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization; GO:0007343 egg activation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009306 protein secretion; GO:0009566 fertilization; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0018996 molting cycle"," collagen and cuticulin-based cuticle; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032940 secretion by cell; GO:0032963 collagen metabolic process; GO:0033036 macromolecule localization; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034035 purine ribonucleoside bisphosphate metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0040002 collagen and cuticulin-based cuticle development; GO:0040012 regulation of locomotion; GO:0042303 molting cycle; GO:0042335 cuticle development; GO:0042338 cuticle development involved in collagen and cuticulin-based cuticle molting cycle; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045026 plasma membrane fusion; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048519 negative regulation of biological process; GO:0048580 regulation of post-embryonic development; GO:0048856 anatomical structure development; GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051923 sulfation; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060467 negative regulation of fertilization; GO:0060468 prevention of polyspermy; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0061062 regulation of nematode larval development; GO:0065007 biological regulation; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0080154 regulation of fertilization; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:2000026 regulation of multicellular organismal development; GO:2000241 regulation of reproductive process; GO:2000242 negative regulation of reproductive process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008146 sulfotransferase activity; GO:0008476 protein-tyrosine sulfotransferase activity; GO:0016740 transferase activity; GO:0016782 transferase activity"," transferring sulphur-containing groups; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0140096 catalytic activity"," acting on a protein;","PF13469","PF13469 Sulfotransferase family","O","KOG3988","Protein-tyrosine sulfotransferase TPST1/TPST2",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156584 Cytosolic sulfonation of small molecules;R-HSA-163841 Gamma carboxylation"," hypusine formation and arylsulfatase activation;R-HSA-1643685 Disease;R-HSA-211859 Biological oxidations;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS);R-HSA-9662001 Defective factor VIII causes hemophilia A;R-HSA-9671793 Diseases of hemostasis;R-HSA-9674519 Defective F8 sulfation at Y1699","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156584;https://reactome.org/PathwayBrowser/#/R-HSA-163841;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-9651496;https://reactome.org/PathwayBrowser/#/R-HSA-9662001;https://reactome.org/PathwayBrowser/#/R-HSA-9671793;https://reactome.org/PathwayBrowser/#/R-HSA-9674519","HYPOXIA","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA"]
["O60711","Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1","LPXN",0.633917586,0.005229701,"down",35828.6,34728,33559.3,20334.2,25708.2,19958.5,1.263670607,1.224852572,1.183632657,0.717184899,0.906725262,0.703934003,"nucleus","K24314",null,null,"GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030155 regulation of cell adhesion; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0033628 regulation of cell adhesion mediated by integrin; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050854 regulation of antigen receptor-mediated signaling pathway; GO:0050855 regulation of B cell receptor signaling pathway; GO:0050858 negative regulation of antigen receptor-mediated signaling pathway; GO:0050859 negative regulation of B cell receptor signaling pathway; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2001141 regulation of RNA biosynthetic process;","GO:0002102 podosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery;","GO:0003712 transcription coregulator activity; GO:0140110 transcription regulator activity;","PF00412","PF00412 LIM domain","TZ","KOG1703","Adaptor protein Enigma and related PDZ-LIM proteins"]
["O60716","Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1","CTNND1",1.184899594,0.00041018,"up",50986.8,50258,50604.1,58618.5,59610.9,61696.3,0.922074203,0.908894171,0.91515324,1.060090194,1.078037318,1.115750874,"nucleus","K05690","CTNND1; catenin (cadherin-associated protein)"," delta 1","hsa04520 Adherens junction; hsa04670 Leukocyte transendothelial migration; hsa04015 Rap1 signaling pathway","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001655 urogenital system development; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001822 kidney development; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0006464 cellular protein modification process; GO:0006497 protein lipidation; GO:0006807 nitrogen compound metabolic process; GO:0007043 cell-cell junction assembly; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008544 epidermis development; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009913 epidermal cell differentiation; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010172 embryonic body morphogenesis; GO:0010468 regulation of gene expression; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010954 positive regulation of protein processing; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0018345 protein palmitoylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0022612 gland morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030162 regulation of proteolysis; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030216 keratinocyte differentiation; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031424 keratinization; GO:0031952 regulation of protein autophosphorylation; GO:0031954 positive regulation of protein autophosphorylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032465 regulation of cytokinesis; GO:0032467 positive regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032835 glomerulus development; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034331 cell junction maintenance; GO:0034332 adherens junction organization; GO:0034334 adherens junction maintenance; GO:0034645 cellular macromolecule biosynthetic process; GO:0035272 exocrine system development; GO:0035635 entry of bacterium into host cell; GO:0036211 protein modification process; GO:0042157 lipoprotein metabolic process; GO:0042158 lipoprotein biosynthetic process; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043543 protein acylation; GO:0043547 positive regulation of GTPase activity; GO:0043588 skin development; GO:0043954 cellular component maintenance; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044409 entry into host; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045216 cell-cell junction organization; GO:0045787 positive regulation of cell cycle; GO:0045862 positive regulation of proteolysis; GO:0045937 positive regulation of phosphate metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051302 regulation of cell division; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051701 biological process involved in interaction with host; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060689 cell differentiation involved in salivary gland development; GO:0060690 epithelial cell differentiation involved in salivary gland development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0060996 dendritic spine development; GO:0060997 dendritic spine morphogenesis; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070268 cornification; GO:0070613 regulation of protein processing; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072001 renal system development; GO:0072006 nephron development; GO:0072102 glomerulus morphogenesis; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090596 sensory organ morphogenesis; GO:0097061 dendritic spine organization; GO:0098609 cell-cell adhesion; GO:0099173 postsynapse organization; GO:0106027 neuron projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900084 regulation of peptidyl-tyrosine autophosphorylation; GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903317 regulation of protein maturation; GO:1903319 positive regulation of protein maturation;","GO:0000922 spindle pole; GO:0001533 cornified envelope; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005901 caveola; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0005915 zonula adherens; GO:0005923 bicellular tight junction; GO:0009898 cytoplasmic side of plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016342 catenin complex; GO:0016600 flotillin complex; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030057 desmosome; GO:0030424 axon; GO:0030425 dendrite; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0030496 midbody; GO:0031252 cell leading edge; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043204 perikaryon; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043296 apical junction complex; GO:0044297 cell body; GO:0044309 neuron spine; GO:0044853 plasma membrane raft; GO:0045121 membrane raft; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0051233 spindle midzone; GO:0070160 tight junction; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0097447 dendritic tree; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098590 plasma membrane region; GO:0098794 postsynapse; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098857 membrane microdomain; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0016409 palmitoyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0019904 protein domain specific binding; GO:0045296 cadherin binding; GO:0050839 cell adhesion molecule binding;",null,null,"TW","KOG1048","Neural adherens junction protein Plakophilin and related Armadillo repeat proteins","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY;WP399 WNT SIGNALING PATHWAY AND PLURIPOTENCY","http://www.wikipathways.org/instance/WP3888_r116782;http://www.wikipathways.org/instance/WP399_r119242",null,"R-HSA-1500931 Cell-Cell communication;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-194138 Signaling by VEGF;R-HSA-418990 Adherens junctions interactions;R-HSA-421270 Cell-cell junction organization;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-446728 Cell junction organization;R-HSA-5218920 VEGFR2 mediated vascular permeability;R-HSA-5663205 Infectious disease;R-HSA-8876384 Listeria monocytogenes entry into host cells;R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases","https://reactome.org/PathwayBrowser/#/R-HSA-1500931;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-418990;https://reactome.org/PathwayBrowser/#/R-HSA-421270;https://reactome.org/PathwayBrowser/#/R-HSA-4420097;https://reactome.org/PathwayBrowser/#/R-HSA-446728;https://reactome.org/PathwayBrowser/#/R-HSA-5218920;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-8876384;https://reactome.org/PathwayBrowser/#/R-HSA-8876493;https://reactome.org/PathwayBrowser/#/R-HSA-9006934","APICAL JUNCTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION"]
["O60725","Protein-S-isoprenylcysteine O-methyltransferase OS=Homo sapiens OX=9606 GN=ICMT PE=1 SV=1","ICMT",0.557187868,0.023413757,"nochange",1751.86,2060.58,2690.81,1270,1376.56,976.972,1.037956579,1.220869571,1.594273482,0.75246016,0.815595714,0.578844494,"plasma membrane","K00587","ICMT; protein-S-isoprenylcysteine O-methyltransferase [EC:2.1.1.100]","hsa00900 Terpenoid backbone biosynthesis","GO:0001701 in utero embryonic development; GO:0001889 liver development; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006481 C-terminal protein methylation; GO:0006520 cellular amino acid metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006725 cellular aromatic compound metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008284 positive regulation of cell population proliferation; GO:0009116 nucleoside metabolic process; GO:0009119 ribonucleoside metabolic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0018410 C-terminal protein amino acid modification; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0023051 regulation of signaling; GO:0032259 methylation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035264 multicellular organism growth; GO:0036211 protein modification process; GO:0040007 growth; GO:0042127 regulation of cell population proliferation; GO:0042278 purine nucleoside metabolic process; GO:0042886 amide transport; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043436 oxoacid metabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0045184 establishment of protein localization; GO:0046128 purine ribonucleoside metabolic process; GO:0046483 heterocycle metabolic process; GO:0046498 S-adenosylhomocysteine metabolic process; GO:0046499 S-adenosylmethioninamine metabolic process; GO:0046578 regulation of Ras protein signal transduction; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048589 developmental growth; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061008 hepaticobiliary system development; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072521 purine-containing compound metabolic process; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane; GO:0097164 ammonium ion metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901605 alpha-amino acid metabolic process; GO:1901657 glycosyl compound metabolic process; GO:1902531 regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0003880 protein C-terminal carboxyl O-methyltransferase activity; GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008140 cAMP response element binding protein binding; GO:0008168 methyltransferase activity; GO:0008171 O-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0010340 carboxyl-O-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0051998 protein carboxyl O-methyltransferase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG2628","Farnesyl cysteine-carboxyl methyltransferase","WP5104 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUERSIMONS SYNDROME;WP5102 FAMILIAL PARTIAL LIPODYSTROPHY FPLD;WP4844 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING;WP4879 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES;WP5103 PROGERIAASSOCIATED LIPODYSTROPHY","http://www.wikipathways.org/instance/WP5104_r120389;http://www.wikipathways.org/instance/WP5102_r119174;http://www.wikipathways.org/instance/WP4844_r120398;http://www.wikipathways.org/instance/WP4879_r120399;http://www.wikipathways.org/instance/WP5103_r119170",null,"R-HSA-162582 Signal Transduction;R-HSA-163841 Gamma carboxylation"," hypusine formation and arylsulfatase activation;R-HSA-392499 Metabolism of proteins;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-597592 Post-translational protein modification;R-HSA-9648002 RAS processing","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-163841;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5673001;https://reactome.org/PathwayBrowser/#/R-HSA-5683057;https://reactome.org/PathwayBrowser/#/R-HSA-5684996;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-9648002"]
["O60749","Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2","SNX2",1.157090377,0.002364747,"up",55080.9,57489.3,54839.8,66374.5,64298.3,63035.7,0.915171613,0.955187286,0.911165725,1.102815281,1.068319125,1.04734097,"cytoplasm","K17917","SNX1_2; sorting nexin-1/2","hsa04144 Endocytosis","GO:0000902 cell morphogenesis; GO:0001845 phagolysosome assembly; GO:0006810 transport; GO:0006897 endocytosis; GO:0006906 vesicle fusion; GO:0006909 phagocytosis; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007033 vacuole organization; GO:0007040 lysosome organization; GO:0007610 behavior; GO:0007638 mechanosensory behavior; GO:0008104 protein localization; GO:0008219 cell death; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0034498 early endosome to Golgi transport; GO:0034613 cellular protein localization; GO:0035418 protein localization to synapse; GO:0042147 retrograde transport"," endosome to Golgi; GO:0043277 apoptotic cell clearance; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048284 organelle fusion; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051259 protein complex oligomerization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065003 protein-containing complex assembly; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072673 lamellipodium morphogenesis; GO:0080171 lytic vacuole organization; GO:0090174 organelle membrane fusion; GO:0090382 phagosome maturation; GO:0090385 phagosome-lysosome fusion; GO:0090386 phagosome maturation involved in apoptotic cell clearance; GO:0090387 phagolysosome assembly involved in apoptotic cell clearance; GO:0090389 phagosome-lysosome fusion involved in apoptotic cell clearance; GO:0097194 execution phase of apoptosis; GO:0097581 lamellipodium organization; GO:0098657 import into cell; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1903539 protein localization to postsynaptic membrane; GO:1990778 protein localization to cell periphery;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005768 endosome; GO:0005769 early endosome; GO:0005773 vacuole; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030027 lamellipodium; GO:0030139 endocytic vesicle; GO:0030904 retromer complex; GO:0030905 retromer"," tubulation complex; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032009 early phagosome; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045335 phagocytic vesicle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0120025 plasma membrane bounded cell projection;","GO:0005102 signaling receptor binding; GO:0005154 epidermal growth factor receptor binding; GO:0005158 insulin receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008289 lipid binding; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043621 protein self-association; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0070851 growth factor receptor binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1990459 transferrin receptor binding; GO:1990460 leptin receptor binding;","PF00787; PF09325","PF00787 PX domain; PF09325 Vps5 C terminal like","U","KOG2273","Membrane coat complex Retromer"," subunit VPS5/SNX1"," Sorting nexins"," and related PX domain-containing proteins",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656","PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O60760","Hematopoietic prostaglandin D synthase OS=Homo sapiens OX=9606 GN=HPGDS PE=1 SV=3","HPGDS",0.751358822,0.030809717,"nochange",34841.9,37487.5,35981.3,25032.9,32016.6,24330.7,1.102063409,1.185744809,1.138103093,0.791800766,1.012698026,0.769589896,"cytoplasm","K04097","HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]","hsa05204 Chemical carcinogenesis - DNA adducts; hsa00480 Glutathione metabolism; hsa00590 Arachidonic acid metabolism; hsa00980 Metabolism of xenobiotics by cytochrome P450; hsa00982 Drug metabolism - cytochrome P450; hsa01100 Metabolic pathways","GO:0001516 prostaglandin biosynthetic process; GO:0001676 long-chain fatty acid metabolic process; GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006636 unsaturated fatty acid biosynthetic process; GO:0006690 icosanoid metabolic process; GO:0006692 prostanoid metabolic process; GO:0006693 prostaglandin metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0016053 organic acid biosynthetic process; GO:0019369 arachidonic acid metabolic process; GO:0019371 cyclooxygenase pathway; GO:0019752 carboxylic acid metabolic process; GO:0023052 signaling; GO:0032787 monocarboxylic acid metabolic process; GO:0033559 unsaturated fatty acid metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046456 icosanoid biosynthetic process; GO:0046457 prostanoid biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901685 glutathione derivative metabolic process; GO:1901687 glutathione derivative biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004364 glutathione transferase activity; GO:0004667 prostaglandin-D synthase activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0016765 transferase activity"," transferring alkyl or aryl (other than methyl) groups; GO:0016853 isomerase activity; GO:0016860 intramolecular oxidoreductase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046983 protein dimerization activity;","PF02798; PF14497","PF02798 Glutathione S-transferase"," N-terminal domain; PF14497 Glutathione S-transferase"," C-terminal domain","O","KOG1695","Glutathione S-transferase","WP2586 ARYL HYDROCARBON RECEPTOR PATHWAY WP2586;WP98 PROSTAGLANDIN SYNTHESIS AND REGULATION","http://www.wikipathways.org/instance/WP2586_r120796;http://www.wikipathways.org/instance/WP98_r117172",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-211859 Biological oxidations;R-HSA-2142753 Arachidonic acid metabolism;R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX);R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-2142753;https://reactome.org/PathwayBrowser/#/R-HSA-2162123;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868"]
["O60762","Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=DPM1 PE=1 SV=1","DPM1",1.167551309,0.004915212,"up",32089.6,32570.4,33684.8,37900.4,36931.3,39990.9,0.903222538,0.916755564,0.948122462,1.066778504,1.03950135,1.125619583,"nucleus","K00721","DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]","hsa00510 N-Glycan biosynthesis; hsa01100 Metabolic pathways","GO:0006066 alcohol metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006497 protein lipidation; GO:0006505 GPI anchor metabolic process; GO:0006506 GPI anchor biosynthetic process; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006664 glycolipid metabolic process; GO:0006720 isoprenoid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009247 glycolipid biosynthetic process; GO:0009987 cellular process; GO:0016093 polyprenol metabolic process; GO:0019348 dolichol metabolic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019673 GDP-mannose metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035268 protein mannosylation; GO:0035269 protein O-linked mannosylation; GO:0036211 protein modification process; GO:0042157 lipoprotein metabolic process; GO:0042158 lipoprotein biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0046467 membrane lipid biosynthetic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097502 mannosylation; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1903509 liposaccharide metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031501 mannosyltransferase complex; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0033185 dolichol-phosphate-mannose synthase complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000030 mannosyltransferase activity; GO:0003824 catalytic activity; GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity; GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity; GO:0005488 binding; GO:0005537 mannose binding; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0030246 carbohydrate binding; GO:0036094 small molecule binding; GO:0043178 alcohol binding; GO:0048029 monosaccharide binding;",null,null,"R","KOG2978","Dolichol-phosphate mannosyltransferase","WP4521 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4521_r119311;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-162699 Synthesis of dolichyl-phosphate mannose;R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins;R-HSA-1643685 Disease;R-HSA-3781865 Diseases of glycosylation;R-HSA-392499 Metabolism of proteins;R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide"," LLO) and transfer to a nascent protein;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-446219 Synthesis of substrates in N-glycan biosythesis;R-HSA-4717374 Defective DPM1 causes DPM1-CDG;R-HSA-4719360 Defective DPM3 causes DPM3-CDG;R-HSA-4719377 Defective DPM2 causes DPM2-CDG;R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis;R-HSA-5668914 Diseases of metabolism;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-162699;https://reactome.org/PathwayBrowser/#/R-HSA-163125;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-3781865;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446193;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-446219;https://reactome.org/PathwayBrowser/#/R-HSA-4717374;https://reactome.org/PathwayBrowser/#/R-HSA-4719360;https://reactome.org/PathwayBrowser/#/R-HSA-4719377;https://reactome.org/PathwayBrowser/#/R-HSA-5609975;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["O60763","General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2","USO1",1.019134558,0.388870804,"nochange",71793.8,74191.9,71145,75944.8,72398.5,72942.1,0.982543296,1.015362803,0.97366406,1.039352341,0.990818996,0.998258504,"cytoplasm",{"$nulls":3},"GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006891 intra-Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008104 protein localization; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010564 regulation of cell cycle process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042886 amide transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044719 regulation of imaginal disc-derived wing size; GO:0045056 transcytosis; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048211 Golgi vesicle docking; GO:0048219 inter-Golgi cisterna vesicle-mediated transport; GO:0048278 vesicle docking; GO:0048513 animal organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051726 regulation of cell cycle; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090114 COPII-coated vesicle budding; GO:0140056 organelle localization by membrane tethering; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition;","GO:0000139 Golgi membrane; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005798 Golgi-associated vesicle; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0012507 ER to Golgi transport vesicle membrane; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030133 transport vesicle; GO:0030134 COPII-coated ER to Golgi transport vesicle; GO:0030135 coated vesicle; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0030662 coated vesicle membrane; GO:0031090 organelle membrane; GO:0031312 extrinsic component of organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0090498 extrinsic component of Golgi membrane; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;",null,null,"U","KOG0946","ER-Golgi vesicle-tethering protein p115",{"$nulls":3},"R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization;R-HSA-1640170 Cell Cycle;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-68875 Mitotic Prophase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-162658;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-68875;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-948021","MTORC1 SIGNALING;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O60783","28S ribosomal protein S14"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1","MRPS14",0.817664865,0.118462339,"nochange",2421.38,2420.04,2664.1,2419.53,1703.8,2013.67,1.064926421,1.064337087,1.171675028,1.064112789,0.749333701,0.885614974,"mitochondria","K02954","RP-S14; small subunit ribosomal protein S14","hsa03010 Ribosome","GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000314 organellar small ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005763 mitochondrial small ribosomal subunit; GO:0005840 ribosome; GO:0015935 small ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;",null,null,"J","KOG1741","Mitochondrial/chloroplast ribosomal protein S14/S29",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["O60784","Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2","TOM1",1.074144685,0.357861175,"nochange",7470.36,7539.06,6024.05,7627.6,7398.89,7566.5,1.027407679,1.036856073,0.828494909,1.049033087,1.017578323,1.04062993,"cytoplasm",{"$nulls":3},"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006955 immune response; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0023052 signaling; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042886 amide transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045321 leukocyte activation; GO:0045786 negative regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045930 negative regulation of mitotic cell cycle; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0065007 biological regulation; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0098657 import into cell;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005768 endosome; GO:0005769 early endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0035577 azurophil granule membrane; GO:0035579 specific granule membrane; GO:0042581 specific granule; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030276 clathrin binding;","PF00790; PF03127","PF00790 VHS domain; PF03127 GAT domain","U","KOG1087","Cytosolic sorting protein GGA2/TOM1",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O60825","6-phosphofructo-2-kinase/fructose-2","6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2 PE=1 SV=2","PFKFB2",0.628421846,3.06113E-4,"down",3587.18,3243.47,3588.8,2240.43,2092.95,2214.43,1.268506524,1.146963034,1.269079392,0.792265811,0.740113607,0.783071633,"cytoplasm","nucleus","K19029","PFKFB2; 6-phosphofructo-2-kinase / fructose-2","6-biphosphatase 2 [EC:2.7.1.105 3.1.3.46]","hsa00051 Fructose and mannose metabolism; hsa04919 Thyroid hormone signaling pathway; hsa04152 AMPK signaling pathway; hsa01100 Metabolic pathways","GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006000 fructose metabolic process; GO:0006003 fructose 2","6-bisphosphate metabolic process; GO:0006006 glucose metabolic process; GO:0006007 glucose catabolic process; GO:0006082 organic acid metabolic process; GO:0006089 lactate metabolic process; GO:0006090 pyruvate metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006096 glycolytic process; GO:0006109 regulation of carbohydrate metabolic process; GO:0006110 regulation of glycolytic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006165 nucleoside diphosphate phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006754 ATP biosynthetic process; GO:0006757 ATP generation from ADP; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009132 nucleoside diphosphate metabolic process; GO:0009135 purine nucleoside diphosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009142 nucleoside triphosphate biosynthetic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009145 purine nucleoside triphosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009166 nucleotide catabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009179 purine ribonucleoside diphosphate metabolic process; GO:0009185 ribonucleoside diphosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009201 ribonucleoside triphosphate biosynthetic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009206 purine ribonucleoside triphosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010676 positive regulation of cellular carbohydrate metabolic process; GO:0010817 regulation of hormone levels; GO:0010906 regulation of glucose metabolic process; GO:0016052 carbohydrate catabolic process; GO:0016053 organic acid biosynthetic process; GO:0016310 phosphorylation; GO:0016311 dephosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019318 hexose metabolic process; GO:0019320 hexose catabolic process; GO:0019359 nicotinamide nucleotide biosynthetic process; GO:0019362 pyridine nucleotide metabolic process; GO:0019363 pyridine nucleotide biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030810 positive regulation of nucleotide biosynthetic process; GO:0030811 regulation of nucleotide catabolic process; GO:0030813 positive regulation of nucleotide catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032024 positive regulation of insulin secretion; GO:0032787 monocarboxylic acid metabolic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033131 regulation of glucokinase activity; GO:0033133 positive regulation of glucokinase activity; GO:0033674 positive regulation of kinase activity; GO:0034284 response to monosaccharide; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042866 pyruvate biosynthetic process; GO:0043085 positive regulation of catalytic activity; GO:0043436 oxoacid metabolic process; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043470 regulation of carbohydrate catabolic process; GO:0043549 regulation of kinase activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0045821 positive regulation of glycolytic process; GO:0045913 positive regulation of carbohydrate metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045981 positive regulation of nucleotide metabolic process; GO:0046031 ADP metabolic process; GO:0046034 ATP metabolic process; GO:0046365 monosaccharide catabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0046700 heterocycle catabolic process; GO:0046835 carbohydrate phosphorylation; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0046939 nucleotide phosphorylation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0062012 regulation of small molecule metabolic process; GO:0062013 positive regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072524 pyridine-containing compound metabolic process; GO:0072525 pyridine-containing compound biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:0090407 organophosphate biosynthetic process; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900373 positive regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1900544 positive regulation of purine nucleotide metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1903299 regulation of hexokinase activity; GO:1903301 positive regulation of hexokinase activity; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903578 regulation of ATP metabolic process; GO:1903580 positive regulation of ATP metabolic process; GO:1904951 positive regulation of establishment of protein localization; GO:2001169 regulation of ATP biosynthetic process; GO:2001171 positive regulation of ATP biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0003873 6-phosphofructo-2-kinase activity; GO:0004331 fructose-2","6-bisphosphate 2-phosphatase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008443 phosphofructokinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0019200 carbohydrate kinase activity; GO:0019203 carbohydrate phosphatase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0042578 phosphoric ester hydrolase activity; GO:0050308 sugar-phosphatase activity;","PF00300","PF00300 Histidine phosphatase superfamily (branch 1)","G","KOG0234","Fructose-6-phosphate 2-kinase/fructose-2","6-biphosphatase","WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS","http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP4746_r120402",null,"R-HSA-1430728 Metabolism;R-HSA-70171 Glycolysis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates;R-HSA-9634600 Regulation of glycolysis by fructose 2","6-bisphosphate metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70171;https://reactome.org/PathwayBrowser/#/R-HSA-70326;https://reactome.org/PathwayBrowser/#/R-HSA-71387;https://reactome.org/PathwayBrowser/#/R-HSA-9634600"]
["O60826","Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1","CCDC22",0.662304588,0.000251305,"down",23929.9,25485.2,25426.9,16238.9,17388.8,15940.5,1.154080614,1.229088933,1.226277267,0.783162474,0.838619342,0.768771371,"cytoplasm","K23343",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006878 cellular copper ion homeostasis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006893 Golgi to plasma membrane transport; GO:0007253 cytoplasmic sequestering of NF-kappaB; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030003 cellular cation homeostasis; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0033036 macromolecule localization; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0042592 homeostatic process; GO:0042632 cholesterol homeostasis; GO:0042994 cytoplasmic sequestering of transcription factor; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043687 post-translational protein modification; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045185 maintenance of protein location; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0046916 cellular transition metal ion homeostasis; GO:0048193 Golgi vesicle transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051220 cytoplasmic sequestering of protein; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0055065 metal ion homeostasis; GO:0055070 copper ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055088 lipid homeostasis; GO:0055092 sterol homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0097006 regulation of plasma lipoprotein particle levels; GO:0098771 inorganic ion homeostasis; GO:0098876 vesicle-mediated transport to the plasma membrane; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005488 binding; GO:0005515 protein binding; GO:0097602 cullin family protein binding;",null,null,"S","KOG1937","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8951664 Neddylation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8951664"]
["O60828","Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1","PQBP1",1.123968109,1.315011E-3,"up",121257,125282,121717,140540,137746,135622,0.930165541,0.961041418,0.933694212,1.078085926,1.05665308,1.040359822,"nucleus","K12865","PQBP1; polyglutamine-binding protein 1","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000380 alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002218 activation of innate immune response; GO:0002230 positive regulation of defense response to virus by host; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0003008 system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006417 regulation of translation; GO:0006629 lipid metabolic process; GO:0006638 neutral lipid metabolic process; GO:0006639 acylglycerol metabolic process; GO:0006641 triglyceride metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007635 chemosensory behavior; GO:0008152 metabolic process; GO:0008306 associative learning; GO:0008355 olfactory learning; GO:0008380 RNA splicing; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032528 microvillus organization; GO:0033043 regulation of organelle organization; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042048 olfactory behavior; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042221 response to chemical; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043330 response to exogenous dsRNA; GO:0043331 response to dsRNA; GO:0043484 regulation of RNA splicing; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045724 positive regulation of cilium assembly; GO:0045727 positive regulation of translation; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050688 regulation of defense response to virus; GO:0050691 regulation of defense response to virus by host; GO:0050767 regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051607 defense response to virus; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060491 regulation of cell projection assembly; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071359 cellular response to dsRNA; GO:0071360 cellular response to exogenous dsRNA; GO:0071407 cellular response to organic cyclic compound; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:0090596 sensory organ morphogenesis; GO:0098542 defense response to other organism; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901360 organic cyclic compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1902017 regulation of cilium assembly; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902855 regulation of non-motile cilium assembly; GO:1902857 positive regulation of non-motile cilium assembly; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005791 rough endoplasmic reticulum; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005929 cilium; GO:0010494 cytoplasmic stress granule; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032838 plasma membrane bounded cell projection cytoplasm; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071598 neuronal ribonucleoprotein granule; GO:0097546 ciliary base; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0120111 neuron projection cytoplasm; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0043021 ribonucleoprotein complex binding; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG3427","Polyglutamine tract-binding protein PQBP-1",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O60830","Mitochondrial import inner membrane translocase subunit Tim17-B OS=Homo sapiens OX=9606 GN=TIMM17B PE=1 SV=1","TIMM17B",0.944931057,0.70056017,"nochange",25580.7,33531.8,36640.2,28766.6,30124.3,31588.8,0.824154121,1.080321147,1.180466986,0.926796841,0.970538961,1.017721943,"plasma membrane","K17795",null,null,"GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008104 protein localization; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0030150 protein import into mitochondrial matrix; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0065002 intracellular protein transmembrane transport; GO:0070585 protein localization to mitochondrion; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:1990542 mitochondrial transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005744 TIM23 mitochondrial import inner membrane translocase complex; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031304 intrinsic component of mitochondrial inner membrane; GO:0031305 integral component of mitochondrial inner membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098573 intrinsic component of mitochondrial membrane; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex;","GO:0005215 transporter activity; GO:0008320 protein transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015450 protein-transporting ATPase activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022884 macromolecule transmembrane transporter activity; GO:0042887 amide transmembrane transporter activity; GO:1904680 peptide transmembrane transporter activity;",null,null,"U","KOG1652","Mitochondrial import inner membrane translocase"," subunit TIM17",{"$nulls":3},"R-HSA-1268020 Mitochondrial protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1268020;https://reactome.org/PathwayBrowser/#/R-HSA-9609507"]
["O60831","PRA1 family protein 2 OS=Homo sapiens OX=9606 GN=PRAF2 PE=1 SV=1","PRAF2",1.184931902,0.001801919,"up",17098.2,16195.4,16994.1,19348.5,20404.1,19834.9,0.933688403,0.884388834,0.928003772,1.056571456,1.114215037,1.083132499,"plasma membrane","K20392",null,null,"GO:0003333 amino acid transmembrane transport; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006835 dicarboxylic acid transport; GO:0006836 neurotransmitter transport; GO:0006855 xenobiotic transmembrane transport; GO:0006865 amino acid transport; GO:0009636 response to toxic substance; GO:0010033 response to organic substance; GO:0015711 organic anion transport; GO:0015800 acidic amino acid transport; GO:0015807 L-amino acid transport; GO:0015813 L-glutamate transmembrane transport; GO:0015849 organic acid transport; GO:0034220 ion transmembrane transport; GO:0042221 response to chemical; GO:0045471 response to ethanol; GO:0046677 response to antibiotic; GO:0046942 carboxylic acid transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0097305 response to alcohol; GO:0098656 anion transmembrane transport; GO:1901700 response to oxygen-containing compound; GO:1902475 L-alpha-amino acid transmembrane transport; GO:1903825 organic acid transmembrane transport; GO:1905039 carboxylic acid transmembrane transport;",null,"GO:0005488 binding; GO:0005515 protein binding;",null,null,"ET","KOG4050","Glutamate transporter EAAC1-interacting protein GTRAP3-18",{"$nulls":5},"IL2 STAT5 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING"]
["O60832","H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3","DKC1",1.089225695,0.016441801,"nochange",129591,131005,137787,143103,143168,147658,0.934200156,0.944393449,0.993283769,1.031605936,1.032074511,1.06444218,"cytoplasm","K11131","DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000003 reproduction; GO:0000154 rRNA modification; GO:0000454 snoRNA guided rRNA pseudouridine synthesis; GO:0000455 enzyme-directed rRNA pseudouridine synthesis; GO:0000495 box H/ACA RNA 3'-end processing; GO:0000723 telomere maintenance; GO:0001522 pseudouridine synthesis; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006278 RNA-dependent DNA biosynthetic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006403 RNA localization; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007004 telomere maintenance via telomerase; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007444 imaginal disc development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009451 RNA modification; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010833 telomere maintenance via telomere lengthening; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016072 rRNA metabolic process; GO:0016073 snRNA metabolic process; GO:0016074 sno(s)RNA metabolic process; GO:0016556 mRNA modification; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030154 cell differentiation; GO:0031118 rRNA pseudouridine synthesis; GO:0031120 snRNA pseudouridine synthesis; GO:0031123 RNA 3'-end processing; GO:0031126 sno(s)RNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032200 telomere organization; GO:0032204 regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032212 positive regulation of telomere maintenance via telomerase; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033979 box H/ACA RNA metabolic process; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0034964 box H/ACA RNA processing; GO:0035220 wing disc development; GO:0035295 tube development; GO:0040031 snRNA modification; GO:0042127 regulation of cell population proliferation; GO:0042254 ribosome biogenesis; GO:0042592 homeostatic process; GO:0043085 positive regulation of catalytic activity; GO:0043144 sno(s)RNA processing; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043487 regulation of RNA stability; GO:0043489 RNA stabilization; GO:0043628 ncRNA 3'-end processing; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051972 regulation of telomerase activity; GO:0051973 positive regulation of telomerase activity; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070202 regulation of establishment of protein localization to chromosome; GO:0070203 regulation of establishment of protein localization to telomere; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090666 scaRNA localization to Cajal body; GO:0090669 telomerase RNA stabilization; GO:0090670 RNA localization to Cajal body; GO:0090685 RNA localization to nucleus; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902369 negative regulation of RNA catabolic process; GO:1903829 positive regulation of protein localization; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904358 positive regulation of telomere maintenance via telomere lengthening; GO:1904814 regulation of protein localization to chromosome"," telomeric region; GO:1904816 positive regulation of protein localization to chromosome"," telomeric region; GO:1904851 positive regulation of establishment of protein localization to telomere; GO:1904872 regulation of telomerase RNA localization to Cajal body; GO:1904874 positive regulation of telomerase RNA localization to Cajal body; GO:1904951 positive regulation of establishment of protein localization; GO:1990481 mRNA pseudouridine synthesis; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000573 positive regulation of DNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005697 telomerase holoenzyme complex; GO:0005730 nucleolus; GO:0005732 sno(s)RNA-containing ribonucleoprotein complex; GO:0015030 Cajal body; GO:0016604 nuclear body; GO:0031429 box H/ACA snoRNP complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0072588 box H/ACA RNP complex; GO:0072589 box H/ACA scaRNP complex; GO:0090661 box H/ACA telomerase RNP complex; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003720 telomerase activity; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0003964 RNA-directed DNA polymerase activity; GO:0005488 binding; GO:0009982 pseudouridine synthase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0016853 isomerase activity; GO:0016866 intramolecular transferase activity; GO:0030515 snoRNA binding; GO:0034061 DNA polymerase activity; GO:0034513 box H/ACA snoRNA binding; GO:0070034 telomerase RNA binding; GO:0097159 organic cyclic compound binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding;","PF08068","PF08068 DKCLD (NUC011) domain","J","KOG2529","Pseudouridine synthase",{"$nulls":3},"R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-171319 Telomere Extension By Telomerase;R-HSA-180786 Extension of Telomeres;R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-72312 rRNA processing;R-HSA-73886 Chromosome Maintenance;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-157579;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-171319;https://reactome.org/PathwayBrowser/#/R-HSA-180786;https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-73886;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","G2M CHECKPOINT;UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["O60841","Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4","EIF5B",0.981486661,0.498605946,"nochange",59005.2,59549.1,58415.4,55445.2,60531.4,57716.8,1.009604946,1.018911314,0.999513208,0.948691779,1.035718899,0.987559854,"cytoplasm","K03243",null,null,"GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0034248 regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003743 translation initiation factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0017151 DEAD/H-box RNA helicase binding; GO:0019899 enzyme binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00009; PF03144; PF11987","PF00009 Elongation factor Tu GTP binding domain; PF03144 Elongation factor Tu domain 2; PF11987 Translation-initiation factor 2","J","KOG1144","Translation initiation factor 5B (eIF-5B)","WP4352 CILIARY LANDSCAPE;WP107 TRANSLATION FACTORS","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP107_r117851",null,"R-HSA-392499 Metabolism of proteins;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["O60858","E3 ubiquitin-protein ligase TRIM13 OS=Homo sapiens OX=9606 GN=TRIM13 PE=1 SV=2","TRIM13",0.781023014,0.040245274,"nochange",5629.35,5581,5990.59,4265.03,3961.47,5207.83,1.102523333,1.093053856,1.173273159,0.835317593,0.775864551,1.019967508,"nucleus","K12003",null,null,"GO:0002376 immune system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006517 protein deglycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010332 response to gamma radiation; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016567 protein ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032502 developmental process; GO:0032897 negative regulation of viral transcription; GO:0033554 cellular response to stress; GO:0034976 response to endoplasmic reticulum stress; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0036507 protein demannosylation; GO:0036508 protein alpha-1","2-demannosylation; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042221 response to chemical; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0046782 regulation of viral transcription; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0051865 protein autoubiquitination; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903900 regulation of viral life cycle; GO:1903901 negative regulation of viral life cycle; GO:1904380 endoplasmic reticulum mannose trimming; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0097038 perinuclear endoplasmic reticulum; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0140096 catalytic activity"," acting on a protein;","PF13445; PF00643","PF13445 RING-type zinc-finger; PF00643 B-box zinc finger","O","KOG2177","Predicted E3 ubiquitin ligase",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle;R-HSA-597592 Post-translational protein modification;R-HSA-901032 ER Quality Control Compartment (ERQC);R-HSA-901042 Calnexin/calreticulin cycle","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-532668;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-901032;https://reactome.org/PathwayBrowser/#/R-HSA-901042"]
["O60869","Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1","EDF1",0.800029569,0.021141173,"nochange",24773.1,27123,26565,19873.9,19630.3,23267,1.052440554,1.152271825,1.128566199,0.844306862,0.833957954,0.988456607,"mitochondria","K03627",null,null,"GO:0003158 endothelium development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007424 open tracheal system development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0030154 cell differentiation; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0043388 positive regulation of DNA binding; GO:0044093 positive regulation of molecular function; GO:0045446 endothelial cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051101 regulation of DNA binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0030674 protein-macromolecule adaptor activity; GO:0060090 molecular adaptor activity; GO:0140110 transcription regulator activity;","PF01381","PF01381 Helix-turn-helix","K","KOG3398","Transcription factor MBF1",{"$nulls":5},"DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["O60870","DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2","KIN",0.494588597,{"v":3.61991e-05,"d":"3.62E-05"},"down",13441.8,13687.5,14778.5,6924.33,7134.29,6668.5,1.287633161,1.311169552,1.415679943,0.663303793,0.683416535,0.638797016,"nucleus","K13102",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0016363 nuclear matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF18131","PF18131 KN17 SH3-like C-terminal domain","A","KOG2837","Protein containing a U1-type Zn-finger and implicated in RNA splicing or processing ",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8876725 Protein methylation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8876725"]
["O60884","DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1","DNAJA2",1.324630282,0.005487369,"up",34829.9,35327.5,38398.4,44214.8,48719.5,50862,0.828126257,0.839957345,0.912971994,1.051264483,1.158369595,1.209310325,"cytoplasm","K09503","DNAJA2; DnaJ homolog subfamily A member 2","hsa04141 Protein processing in endoplasmic reticulum","GO:0006457 protein folding; GO:0006950 response to stress; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0018885 carbon tetrachloride metabolic process; GO:0032781 positive regulation of ATP-dependent activity; GO:0035966 response to topologically incorrect protein; GO:0042026 protein refolding; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0043085 positive regulation of catalytic activity; GO:0043462 regulation of ATP-dependent activity; GO:0044093 positive regulation of molecular function; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0001671 ATPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0030234 enzyme regulator activity; GO:0051082 unfolded protein binding; GO:0051087 chaperone binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0060590 ATPase regulator activity; GO:0098772 molecular function regulator;","PF00226; PF01556; PF00684","PF00226 DnaJ domain; PF01556 DnaJ C terminal domain; PF00684 DnaJ central domain","O","KOG0712","Molecular chaperone (DnaJ superfamily)",{"$nulls":3},"R-HSA-2262752 Cellular responses to stress;R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3371497;https://reactome.org/PathwayBrowser/#/R-HSA-8953897"]
["O60885","Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2","BRD4",1.450270034,0.000739501,"up",33913.1,36739,32742.3,49143.4,52081.4,48725,0.803170548,0.870096888,0.775442264,1.163872708,1.233453933,1.153963659,"nucleus","K11722",null,null,"GO:0000003 reproduction; GO:0000082 G1/S transition of mitotic cell cycle; GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0000578 embryonic axis specification; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001701 in utero embryonic development; GO:0001708 cell fate specification; GO:0001824 blastocyst development; GO:0001832 blastocyst growth; GO:0001833 inner cell mass cell proliferation; GO:0001932 regulation of protein phosphorylation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002574 thrombocyte differentiation; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007346 regulation of mitotic cell cycle; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007354 zygotic determination of anterior/posterior axis"," embryo; GO:0007362 terminal region determination; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008380 RNA splicing; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009996 negative regulation of cell fate specification; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010453 regulation of cell fate commitment; GO:0010454 negative regulation of cell fate commitment; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010971 positive regulation of G2/M transition of mitotic cell cycle; GO:0014016 neuroblast differentiation; GO:0014017 neuroblast fate commitment; GO:0014018 neuroblast fate specification; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016310 phosphorylation; GO:0016358 dendrite development; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032101 regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032784 regulation of DNA-templated transcription"," elongation; GO:0032786 positive regulation of DNA-templated transcription"," elongation; GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034243 regulation of transcription elongation from RNA polymerase II promoter; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035282 segmentation; GO:0036211 protein modification process; GO:0040007 growth; GO:0040011 locomotion; GO:0040028 regulation of vulval development; GO:0042325 regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042659 regulation of cell fate specification; GO:0043009 chordate embryonic development; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043388 positive regulation of DNA binding; GO:0043412 macromolecule modification; GO:0043543 protein acylation; GO:0043966 histone H3 acetylation; GO:0043967 histone H4 acetylation; GO:0043983 histone H4-K12 acetylation; GO:0044093 positive regulation of molecular function; GO:0044154 histone H3-K14 acetylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045787 positive regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045931 positive regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046716 muscle cell cellular homeostasis; GO:0046777 protein autophosphorylation; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048580 regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048863 stem cell differentiation; GO:0048865 stem cell fate commitment; GO:0048866 stem cell fate specification; GO:0048869 cellular developmental process; GO:0050727 regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050879 multicellular organismal movement; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051101 regulation of DNA binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0061062 regulation of nematode larval development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071168 protein localization to chromatin; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071965 multicellular organismal locomotion; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901360 organic cyclic compound metabolic process; GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain; GO:1901564 organonitrogen compound metabolic process; GO:1901976 regulation of cell cycle checkpoint; GO:1901977 negative regulation of cell cycle checkpoint; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902751 positive regulation of cell cycle G2/M phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000001 regulation of DNA damage checkpoint; GO:2000002 negative regulation of DNA damage checkpoint; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001020 regulation of response to DNA damage stimulus; GO:2001021 negative regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000307 cyclin-dependent protein kinase holoenzyme complex; GO:0000428 DNA-directed RNA polymerase complex; GO:0000785 chromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005665 RNA polymerase II"," core complex; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0008023 transcription elongation factor complex; GO:0008024 cyclin/CDK positive transcription elongation factor complex; GO:0016591 RNA polymerase II"," holoenzyme; GO:0016604 nuclear body; GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032806 carboxy-terminal domain protein kinase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0070090 metaphase plate; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0000993 RNA polymerase II complex binding; GO:0001098 basal transcription machinery binding; GO:0001099 basal RNA polymerase II transcription machinery binding; GO:0002039 p53 binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0032182 ubiquitin-like protein binding; GO:0032183 SUMO binding; GO:0034211 GTP-dependent protein kinase activity; GO:0042393 histone binding; GO:0043175 RNA polymerase core enzyme binding; GO:0044877 protein-containing complex binding; GO:0045309 protein phosphorylated amino acid binding; GO:0050815 phosphoserine residue binding; GO:0051219 phosphoprotein binding; GO:0070063 RNA polymerase binding; GO:0070577 lysine-acetylated histone binding; GO:0097159 organic cyclic compound binding; GO:0099122 RNA polymerase II C-terminal domain binding; GO:0140030 modification-dependent protein binding; GO:0140033 acetylation-dependent protein binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding; GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding;","PF00439; PF17035","PF00439 Bromodomain; PF17035 Bromodomain extra-terminal - transcription regulation","K","KOG1474","Transcription initiation factor TFIID"," subunit BDF1 and related bromodomain proteins","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP5055 BURN WOUND HEALING;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP5055_r120278;http://www.wikipathways.org/instance/WP3888_r116782","Transcription factor","R-HSA-1643685 Disease;R-HSA-5663205 Infectious disease;R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-9679191;https://reactome.org/PathwayBrowser/#/R-HSA-9679506"]
["O60888","Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2","CUTA",1.276450702,0.022435308,"nochange",128054,137902,128353,152637,162520,188159,0.855952096,0.921779139,0.857950703,1.020272385,1.08633338,1.257712296,"extracellular","K03926",null,null,"GO:0008104 protein localization; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0033036 macromolecule localization; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0051179 localization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0065003 protein-containing complex assembly; GO:0071840 cellular component organization or biogenesis;","GO:0016020 membrane;","GO:0005488 binding; GO:0005507 copper ion binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding;","PF03091","PF03091 CutA1 divalent ion tolerance protein","P","KOG3338","Divalent cation tolerance-related protein"]
["O60890","Oligophrenin-1 OS=Homo sapiens OX=9606 GN=OPHN1 PE=1 SV=1","OPHN1",1.466821225,0.192538304,"nochange",3176.31,3801.11,3771.47,3614.68,4725.03,7426.99,0.718741691,0.860122667,0.85341567,0.817936919,1.069189107,1.680593945,"nucleus","K20650",null,null,"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001738 morphogenesis of a polarized epithelium; GO:0002009 morphogenesis of an epithelium; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006929 substrate-dependent cell migration; GO:0006930 substrate-dependent cell migration"," cell extension; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0019222 regulation of metabolic process; GO:0021533 cell differentiation in hindbrain; GO:0021549 cerebellum development; GO:0021575 hindbrain morphogenesis; GO:0021587 cerebellum morphogenesis; GO:0021681 cerebellar granular layer development; GO:0021683 cerebellar granular layer morphogenesis; GO:0021684 cerebellar granular layer formation; GO:0021695 cerebellar cortex development; GO:0021696 cerebellar cortex morphogenesis; GO:0021697 cerebellar cortex formation; GO:0021707 cerebellar granule cell differentiation; GO:0021895 cerebral cortex neuron differentiation; GO:0021953 central nervous system neuron differentiation; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030182 neuron differentiation; GO:0030855 epithelial cell differentiation; GO:0030859 polarized epithelial cell differentiation; GO:0030900 forebrain development; GO:0030902 hindbrain development; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0035023 regulation of Rho protein signal transduction; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035089 establishment of apical/basal cell polarity; GO:0036465 synaptic vesicle recycling; GO:0040011 locomotion; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045198 establishment of epithelial cell apical/basal polarity; GO:0045861 negative regulation of proteolysis; GO:0046578 regulation of Ras protein signal transduction; GO:0048468 cell development; GO:0048488 synaptic vesicle endocytosis; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051966 regulation of synaptic transmission"," glutamatergic; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060627 regulation of vesicle-mediated transport; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061162 establishment of monopolar cell polarity; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061339 establishment or maintenance of monopolar cell polarity; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090162 establishment of epithelial cell polarity; GO:0097485 neuron projection guidance; GO:0098657 import into cell; GO:0099003 vesicle-mediated transport in synapse; GO:0099177 regulation of trans-synaptic signaling; GO:0099504 synaptic vesicle cycle; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015629 actin cytoskeleton; GO:0030424 axon; GO:0030425 dendrite; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0044309 neuron spine; GO:0045202 synapse; GO:0097447 dendritic tree; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003779 actin binding; GO:0005096 GTPase activator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0035254 glutamate receptor binding; GO:0035255 ionotropic glutamate receptor binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF16746; PF00169; PF00620","PF16746 BAR domain of APPL family; PF00169 PH domain; PF00620 RhoGAP domain","T","KOG1451","Oligophrenin-1 and related Rho GTPase-activating proteins",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013408 RHOG GTPase cycle;R-HSA-9013409 RHOJ GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013408;https://reactome.org/PathwayBrowser/#/R-HSA-9013409;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","HEDGEHOG SIGNALING;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEDGEHOG_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O60907","F-box-like/WD repeat-containing protein TBL1X OS=Homo sapiens OX=9606 GN=TBL1X PE=1 SV=3","TBL1X",1.321448445,0.271536979,"nochange",2899.12,2402.27,3737.82,2908.5,3859.16,5177.19,0.828949212,0.686884235,1.068759811,0.831631248,1.103454718,1.480320777,"mitochondria","K04508","TBL1; transducin (beta)-like 1","hsa04310 Wnt signaling pathway","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003008 system process; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006476 protein deacetylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008152 metabolic process; GO:0008587 imaginal disc-derived wing margin morphogenesis; GO:0008593 regulation of Notch signaling pathway; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016575 histone deacetylation; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0019941 modification-dependent protein catabolic process; GO:0022008 neurogenesis; GO:0022416 chaeta development; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031063 regulation of histone deacetylation; GO:0031065 positive regulation of histone deacetylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033993 response to lipid; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035601 protein deacylation; GO:0036211 protein modification process; GO:0038127 ERBB signaling pathway; GO:0040008 regulation of growth; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042461 photoreceptor cell development; GO:0042592 homeostatic process; GO:0042675 compound eye cone cell differentiation; GO:0042676 compound eye cone cell fate commitment; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043627 response to estrogen; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045165 cell fate commitment; GO:0045444 fat cell differentiation; GO:0045570 regulation of imaginal disc growth; GO:0045572 positive regulation of imaginal disc growth; GO:0045747 positive regulation of Notch signaling pathway; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046530 photoreceptor cell differentiation; GO:0046620 regulation of organ growth; GO:0046622 positive regulation of organ growth; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050954 sensory perception of mechanical stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070050 neuron cellular homeostasis; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090263 positive regulation of canonical Wnt signaling pathway; GO:0090311 regulation of protein deacetylation; GO:0090312 positive regulation of protein deacetylation; GO:0090596 sensory organ morphogenesis; GO:0098732 macromolecule deacylation; GO:0104004 cellular response to environmental stimulus; GO:1901184 regulation of ERBB signaling pathway; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905269 positive regulation of chromatin organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000118 histone deacetylase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0015630 microtubule cytoskeleton; GO:0017053 transcription repressor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:1902494 catalytic complex;","GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008022 protein C-terminus binding; GO:0008134 transcription factor binding; GO:0019904 protein domain specific binding; GO:0042393 histone binding; GO:0042802 identical protein binding; GO:0047485 protein N-terminus binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF08513","PF08513 LisH","B","KOG0273","Beta-transducin family (WD-40 repeat) protein","WP2858 ECTODERM DIFFERENTIATION;WP4312 RETT SYNDROME CAUSING GENES","http://www.wikipathways.org/instance/WP2858_r116763;http://www.wikipathways.org/instance/WP4312_r119230","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-1368082 RORA activates gene expression;R-HSA-1368108 BMAL1:CLOCK","NPAS2 activates circadian gene expression;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-1592230 Mitochondrial biogenesis;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF);R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-1980143 Signaling by NOTCH1;R-HSA-1989781 PPARA activates gene expression;R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription;R-HSA-212436 Generic Transcription Pathway;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis;R-HSA-2262752 Cellular responses to stress;R-HSA-2426168 Activation of gene expression by SREBF (SREBP);R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer;R-HSA-2644603 Signaling by NOTCH1 in Cancer;R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants;R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer;R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;R-HSA-3214815 HDACs deacetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-350054 Notch-HLH transcription pathway;R-HSA-381340 Transcriptional regulation of white adipocyte differentiation;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-400253 Circadian Clock;R-HSA-4839726 Chromatin organization;R-HSA-556833 Metabolism of lipids;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953897 Cellular responses to stimuli;R-HSA-8957322 Metabolism of steroids;R-HSA-8986944 Transcriptional Regulation by MECP2;R-HSA-9005891 Loss of function of MECP2 in Rett syndrome;R-HSA-9005895 Pervasive developmental disorders;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex;R-HSA-9022692 Regulation of MECP2 expression and activity;R-HSA-9024446 NR1H2 and NR1H3-mediated signaling;R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9675151 Disorders of Developmental Biology;R-HSA-9697154 Disorders of Nervous System Development;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9707616 Heme signaling;R-HSA-9711123 Cellular response to chemical stress"]
["O60921","Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1","HUS1",0.985830805,0.839122861,"nochange",5684.22,5617.27,4853.98,5033.9,5511.64,5381.02,1.063066146,1.050545118,0.907794176,0.94144292,1.030790134,1.006361505,"cytoplasm","K10903","HUS1; HUS1 checkpoint protein","hsa04218 Cellular senescence","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000076 DNA replication checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0001932 regulation of protein phosphorylation; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006275 regulation of DNA replication; GO:0006281 DNA repair; GO:0006289 nucleotide-excision repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007338 single fertilization; GO:0007346 regulation of mitotic cell cycle; GO:0007568 aging; GO:0008152 metabolic process; GO:0008156 negative regulation of DNA replication; GO:0008219 cell death; GO:0008340 determination of adult lifespan; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009566 fertilization; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010212 response to ionizing radiation; GO:0010259 multicellular organism aging; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030717 oocyte karyosome formation; GO:0030720 oocyte localization involved in germarium-derived egg chamber formation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031570 DNA integrity checkpoint signaling; GO:0031573 mitotic intra-S DNA damage checkpoint signaling; GO:0032200 telomere organization; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033043 regulation of organelle organization; GO:0033313 meiotic cell cycle checkpoint signaling; GO:0033314 mitotic DNA replication checkpoint signaling; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0035038 female pronucleus assembly; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040020 regulation of meiotic nuclear division; GO:0042325 regulation of phosphorylation; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044778 meiotic DNA integrity checkpoint signaling; GO:0044818 mitotic G2/M transition checkpoint; GO:0045786 negative regulation of cell cycle; GO:0045835 negative regulation of meiotic nuclear division; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051445 regulation of meiotic cell cycle; GO:0051447 negative regulation of meiotic cell cycle; GO:0051598 meiotic recombination checkpoint signaling; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0061982 meiosis I cell cycle process; GO:0061988 karyosome formation; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070193 synaptonemal complex organization; GO:0070194 synaptonemal complex disassembly; GO:0070925 organelle assembly; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0104004 cellular response to environmental stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000241 regulation of reproductive process; GO:2000242 negative regulation of reproductive process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0030896 checkpoint clamp complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035861 site of double-strand break; GO:0043073 germ cell nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090734 site of DNA damage;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"DL","KOG3999","Checkpoint 9-1-1 complex"," HUS1 component","WP3875 ATR SIGNALING;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR","http://www.wikipathways.org/instance/WP3875_r117657;http://www.wikipathways.org/instance/WP4016_r120667",null,"R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-176187 Activation of ATR in response to replication stress;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5685938 HDR through Single Strand Annealing (SSA);R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-9675135 Diseases of DNA repair;R-HSA-9675136 Diseases of DNA Double-Strand Break Repair;R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function;R-HSA-9709570 Impaired BRCA2 binding to RAD51","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-176187;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5633007;https://reactome.org/PathwayBrowser/#/R-HSA-5685938;https://reactome.org/PathwayBrowser/#/R-HSA-5685942;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693538;https://reactome.org/PathwayBrowser/#/R-HSA-5693567;https://reactome.org/PathwayBrowser/#/R-HSA-5693579;https://reactome.org/PathwayBrowser/#/R-HSA-5693607;https://reactome.org/PathwayBrowser/#/R-HSA-5693616;https://reactome.org/PathwayBrowser/#/R-HSA-6804756;https://reactome.org/PathwayBrowser/#/R-HSA-69473;https://reactome.org/PathwayBrowser/#/R-HSA-69481;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-9675135;https://reactome.org/PathwayBrowser/#/R-HSA-9675136;https://reactome.org/PathwayBrowser/#/R-HSA-9701190;https://reactome.org/PathwayBrowser/#/R-HSA-9709570","E2F TARGETS;G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["O60927","E3 ubiquitin-protein ligase PPP1R11 OS=Homo sapiens OX=9606 GN=PPP1R11 PE=1 SV=1","PPP1R11",0.982402427,0.796728308,"nochange",1436.76,1322.34,910.156,589.186,1801.27,1214.23,1.185129054,1.090748318,0.750753305,0.485997276,1.485799584,1.001572462,"extracellular","K17553",null,null,"GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0016567 protein ubiquitination; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032515 negative regulation of phosphoprotein phosphatase activity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035308 negative regulation of protein dephosphorylation; GO:0036211 protein modification process; GO:0042742 defense response to bacterium; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050830 defense response to Gram-positive bacterium; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051707 response to other organism; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0098542 defense response to other organism; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization;","GO:0000164 protein phosphatase type 1 complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0008287 protein serine/threonine phosphatase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1902494 catalytic complex; GO:1903293 phosphatase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0004857 enzyme inhibitor activity; GO:0004864 protein phosphatase inhibitor activity; GO:0004865 protein serine/threonine phosphatase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008157 protein phosphatase 1 binding; GO:0016740 transferase activity; GO:0019208 phosphatase regulator activity; GO:0019212 phosphatase inhibitor activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019888 protein phosphatase regulator activity; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0030234 enzyme regulator activity; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;",null,null,"S","KOG4102","Uncharacterized conserved protein","WP4861 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION","http://www.wikipathways.org/instance/WP4861_r118973"]
["O60930","Ribonuclease H1 OS=Homo sapiens OX=9606 GN=RNASEH1 PE=1 SV=2","RNASEH1",1.112461671,0.681360543,"nochange",4307.24,5013.62,3104.44,3755.7,6248.62,3818.35,0.984588141,1.146058914,0.709641165,0.858512106,1.42836646,0.872833213,"mitochondria","K03469","rnhA; ribonuclease HI [EC:3.1.26.4]","hsa03030 DNA replication","GO:0000002 mitochondrial genome maintenance; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006264 mitochondrial DNA replication; GO:0006271 DNA strand elongation involved in DNA replication; GO:0006273 lagging strand elongation; GO:0006401 RNA catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0019439 aromatic compound catabolic process; GO:0022616 DNA strand elongation; GO:0032042 mitochondrial DNA metabolic process; GO:0033567 DNA replication"," Okazaki fragment processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0043137 DNA replication"," removal of RNA primer; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090502 RNA phosphodiester bond hydrolysis"," endonucleolytic; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0004521 endoribonuclease activity; GO:0004523 RNA-DNA hybrid ribonuclease activity; GO:0004540 ribonuclease activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016891 endoribonuclease activity"," producing 5'-phosphomonoesters; GO:0016893 endonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF00075","PF00075 RNase H","L","KOG3752","Ribonuclease H"]
["O60934","Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1","NBN",0.833290166,0.002253944,"down",24041.7,24786.1,24530.8,20372.2,21251.6,19505.2,1.072591079,1.105801576,1.094411678,0.908880819,0.948114176,0.870200673,"cytoplasm","K10867","NBN; nibrin","hsa03440 Homologous recombination; hsa04218 Cellular senescence","GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000729 DNA double-strand break processing; GO:0001325 formation of extrachromosomal circular DNA; GO:0001701 in utero embryonic development; GO:0001775 cell activation; GO:0001824 blastocyst development; GO:0001832 blastocyst growth; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002200 somatic diversification of immune receptors; GO:0002204 somatic recombination of immunoglobulin genes involved in immune response; GO:0002208 somatic diversification of immunoglobulins involved in immune response; GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002285 lymphocyte activation involved in immune response; GO:0002312 B cell activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002377 immunoglobulin production; GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response; GO:0002440 production of molecular mediator of immune response; GO:0002443 leukocyte mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002520 immune system development; GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus; GO:0003008 system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006275 regulation of DNA replication; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006955 immune response; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007095 mitotic G2 DNA damage checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010721 negative regulation of cell development; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016043 cellular component organization; GO:0016064 immunoglobulin mediated immune response; GO:0016233 telomere capping; GO:0016444 somatic cell DNA recombination; GO:0016445 somatic diversification of immunoglobulins; GO:0016447 somatic recombination of immunoglobulin gene segments; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019724 B cell mediated immunity; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0022616 DNA strand elongation; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030174 regulation of DNA-dependent DNA replication initiation; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0031000 response to caffeine; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031570 DNA integrity checkpoint signaling; GO:0031860 telomeric 3' overhang formation; GO:0031952 regulation of protein autophosphorylation; GO:0031954 positive regulation of protein autophosphorylation; GO:0032200 telomere organization; GO:0032204 regulation of telomere maintenance; GO:0032205 negative regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032392 DNA geometric change; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032508 DNA duplex unwinding; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035556 intracellular signal transduction; GO:0036270 response to diuretic; GO:0040007 growth; GO:0042113 B cell activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042770 signal transduction in response to DNA damage; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043279 response to alkaloid; GO:0043549 regulation of kinase activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044818 mitotic G2/M transition checkpoint; GO:0045003 double-strand break repair via synthesis-dependent strand annealing; GO:0045190 isotype switching; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045786 negative regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0046596 regulation of viral entry into host cell; GO:0046597 negative regulation of viral entry into host cell; GO:0046649 lymphocyte activation; GO:0048145 regulation of fibroblast proliferation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048589 developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050885 neuromuscular process controlling balance; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090329 regulation of DNA-dependent DNA replication; GO:0090656 t-circle formation; GO:0090737 telomere maintenance via telomere trimming; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:1901360 organic cyclic compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1903047 mitotic cell cycle process; GO:1903900 regulation of viral life cycle; GO:1903901 negative regulation of viral life cycle; GO:1904353 regulation of telomere capping; GO:1904354 negative regulation of telomere capping; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000781 chromosome"," telomeric region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016234 inclusion body; GO:0016604 nuclear body; GO:0016605 PML body; GO:0030870 Mre11 complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035861 site of double-strand break; GO:0042405 nuclear inclusion body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090734 site of DNA damage; GO:0098687 chromosomal region;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0047485 protein N-terminus binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF16508","PF16508 Second BRCT domain on Nijmegen syndrome breakage protein",{"$nulls":3},"WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE;WP2516 ATM SIGNALING PATHWAY;WP4262 BREAST CANCER PATHWAY;WP2942 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR;WP707 DNA DAMAGE RESPONSE;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR;WP3959 DNA IRDOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP186 HOMOLOGOUS RECOMBINATION;WP1530 MIRNA REGULATION OF DNA DAMAGE RESPONSE;WP5118 SMC1SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME","http://www.wikipathways.org/instance/WP3878_r117656;http://www.wikipathways.org/instance/WP2516_r116808;http://www.wikipathways.org/instance/WP4262_r108103;http://www.wikipathways.org/instance/WP2942_r119083;http://www.wikipathways.org/instance/WP707_r116541;http://www.wikipathways.org/instance/WP4016_r120667;http://www.wikipathways.org/instance/WP3959_r118468;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP186_r118416;http://www.wikipathways.org/instance/WP1530_r118120;http://www.wikipathways.org/instance/WP5118_r119397","Transcription factor","R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2559583 Cellular Senescence;R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5685938 HDR through Single Strand Annealing (SSA);R-HSA-5685939 HDR through MMEJ (alt-NHEJ);R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693537 Resolution of D-Loop Structures;R-HSA-5693538 Homology Directed Repair;R-HSA-5693548 Sensing of DNA Double Strand Breaks;R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates;R-HSA-5693571 Nonhomologous End-Joining (NHEJ);R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693606 DNA Double Strand Break Response;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-8953897 Cellular responses to stimuli;R-HSA-912446 Meiotic recombination;R-HSA-9675135 Diseases of DNA repair;R-HSA-9675136 Diseases of DNA Double-Strand Break Repair;R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function;R-HSA-9701192 Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function;R-HSA-9701193 Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function;R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function;R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function;R-HSA-9709570 Impaired BRCA2 binding to RAD51;R-HSA-9709603 Impaired BRCA2 binding to PALB2",null,"E2F TARGETS;FATTY ACID METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM"]
["O60936","Nucleolar protein 3 OS=Homo sapiens OX=9606 GN=NOL3 PE=1 SV=2","NOL3",0.739157691,0.298932792,"nochange",923.093,784.197,1551.61,841.319,676.171,891.351,0.977207321,0.830168845,1.642569765,0.890639498,0.715810056,0.943604515,"cytoplasm","nucleus",{"$nulls":3},"GO:0000245 spliceosomal complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0001666 response to hypoxia; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001960 negative regulation of cytokine-mediated signaling pathway; GO:0001974 blood vessel remodeling; GO:0002931 response to ischemia; GO:0006139 nucleobase-containing compound metabolic process; GO:0006376 mRNA splice site selection; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006839 mitochondrial transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008380 RNA splicing; GO:0008637 apoptotic mitochondrial changes; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010466 negative regulation of peptidase activity; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010522 regulation of calcium ion transport into cytosol; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010656 negative regulation of muscle cell apoptotic process; GO:0010657 muscle cell apoptotic process; GO:0010658 striated muscle cell apoptotic process; GO:0010659 cardiac muscle cell apoptotic process; GO:0010660 regulation of muscle cell apoptotic process; GO:0010662 regulation of striated muscle cell apoptotic process; GO:0010664 negative regulation of striated muscle cell apoptotic process; GO:0010665 regulation of cardiac muscle cell apoptotic process; GO:0010667 negative regulation of cardiac muscle cell apoptotic process; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway; GO:0010821 regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; GO:0010939 regulation of necrotic cell death; GO:0010941 regulation of cell death; GO:0010951 negative regulation of endopeptidase activity; GO:0010955 negative regulation of protein processing; GO:0010959 regulation of metal ion transport; GO:0012501 programmed cell death; GO:0014735 regulation of muscle atrophy; GO:0014736 negative regulation of muscle atrophy; GO:0014745 negative regulation of muscle adaptation; GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; GO:0014874 response to stimulus involved in regulation of muscle adaptation; GO:0014876 response to injury involved in regulation of muscle adaptation; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033002 muscle cell proliferation; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033554 cellular response to stress; GO:0034220 ion transmembrane transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0035556 intracellular signal transduction; GO:0035795 negative regulation of mitochondrial membrane permeability; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043269 regulation of ion transport; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043502 regulation of muscle adaptation; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045445 myoblast differentiation; GO:0045861 negative regulation of proteolysis; GO:0046483 heterocycle metabolic process; GO:0046902 regulation of mitochondrial membrane permeability; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048659 smooth muscle cell proliferation; GO:0048771 tissue remodeling; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051209 release of sequestered calcium ion into cytosol; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051259 protein complex oligomerization; GO:0051279 regulation of release of sequestered calcium ion into cytosol; GO:0051282 regulation of sequestering of calcium ion; GO:0051283 negative regulation of sequestering of calcium ion; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051480 regulation of cytosolic calcium ion concentration; GO:0051481 negative regulation of cytosolic calcium ion concentration; GO:0051560 mitochondrial calcium ion homeostasis; GO:0051562 negative regulation of mitochondrial calcium ion concentration; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051924 regulation of calcium ion transport; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060401 cytosolic calcium ion transport; GO:0060402 calcium ion transport into cytosol; GO:0060547 negative regulation of necrotic cell death; GO:0060548 negative regulation of cell death; GO:0060759 regulation of response to cytokine stimulus; GO:0060761 negative regulation of response to cytokine stimulus; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070296 sarcoplasmic reticulum calcium ion transport; GO:0070482 response to oxygen levels; GO:0070588 calcium ion transmembrane transport; GO:0070613 regulation of protein processing; GO:0070887 cellular response to chemical stimulus; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0090199 regulation of release of cytochrome c from mitochondria; GO:0090201 negative regulation of release of cytochrome c from mitochondria; GO:0090257 regulation of muscle system process; GO:0090304 nucleic acid metabolic process; GO:0090317 negative regulation of intracellular protein transport; GO:0090559 regulation of membrane permeability; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097340 inhibition of cysteine-type endopeptidase activity; GO:0097341 zymogen inhibition; GO:0097553 calcium ion transmembrane import into cytosol; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098771 inorganic ion homeostasis; GO:1900037 regulation of cellular response to hypoxia; GO:1900038 negative regulation of cellular response to hypoxia; GO:1900407 regulation of cellular response to oxidative stress; GO:1900408 negative regulation of cellular response to oxidative stress; GO:1901031 regulation of response to reactive oxygen species; GO:1901032 negative regulation of response to reactive oxygen species; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901360 organic cyclic compound metabolic process; GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors; GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process; GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process; GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902882 regulation of response to oxidative stress; GO:1902883 negative regulation of response to oxidative stress; GO:1903072 regulation of death-inducing signaling complex assembly; GO:1903073 negative regulation of death-inducing signaling complex assembly; GO:1903169 regulation of calcium ion transmembrane transport; GO:1903201 regulation of oxidative stress-induced cell death; GO:1903202 negative regulation of oxidative stress-induced cell death; GO:1903205 regulation of hydrogen peroxide-induced cell death; GO:1903206 negative regulation of hydrogen peroxide-induced cell death; GO:1903214 regulation of protein targeting to mitochondrion; GO:1903215 negative regulation of protein targeting to mitochondrion; GO:1903297 regulation of hypoxia-induced intrinsic apoptotic signaling pathway; GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; GO:1903317 regulation of protein maturation; GO:1903318 negative regulation of protein maturation; GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum; GO:1903533 regulation of protein targeting; GO:1903747 regulation of establishment of protein localization to mitochondrion; GO:1903748 negative regulation of establishment of protein localization to mitochondrion; GO:1903828 negative regulation of protein localization; GO:1904062 regulation of cation transmembrane transport; GO:1904950 negative regulation of establishment of protein localization; GO:1905709 negative regulation of membrane permeability; GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2001023 regulation of response to drug; GO:2001024 negative regulation of response to drug; GO:2001038 regulation of cellular response to drug; GO:2001039 negative regulation of cellular response to drug; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001237 negative regulation of extrinsic apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016528 sarcoplasm; GO:0016529 sarcoplasmic reticulum; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0002020 protease binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0004869 cysteine-type endopeptidase inhibitor activity; GO:0005102 signaling receptor binding; GO:0005123 death receptor binding; GO:0005126 cytokine receptor binding; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019902 phosphatase binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0032813 tumor necrosis factor receptor superfamily binding; GO:0035877 death effector domain binding; GO:0042802 identical protein binding; GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0089720 caspase binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901363 heterocyclic compound binding;","PF00619","PF00619 Caspase recruitment domain",{"$nulls":8},"GLYCOLYSIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS"]
["O60942","mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1","RNGTT",1.457546816,0.002695735,"up",9086.2,9881.5,9986.43,14012,12922.4,15267.6,0.766163084,0.833224067,0.842071934,1.181514509,1.089637674,1.287388732,"cytoplasm","K13917","RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74]","hsa03015 mRNA surveillance pathway","GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008589 regulation of smoothened signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009452 7-methylguanosine RNA capping; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016311 dephosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0036260 RNA capping; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045880 positive regulation of smoothened signaling pathway; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098501 polynucleotide dephosphorylation; GO:0098507 polynucleotide 5' dephosphorylation; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004484 mRNA guanylyltransferase activity; GO:0004651 polynucleotide 5'-phosphatase activity; GO:0004721 phosphoprotein phosphatase activity; GO:0008138 protein tyrosine/serine/threonine phosphatase activity; GO:0008192 RNA guanylyltransferase activity; GO:0016462 pyrophosphatase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0042578 phosphoric ester hydrolase activity; GO:0050355 triphosphatase activity; GO:0070568 guanylyltransferase activity; GO:0098518 polynucleotide phosphatase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00782; PF01331; PF03919","PF00782 Dual specificity phosphatase"," catalytic domain; PF01331 mRNA capping enzyme"," catalytic domain; PF03919 mRNA capping enzyme"," C-terminal domain","A","KOG2386","mRNA capping enzyme"," guanylyltransferase (alpha) subunit","WP4352 CILIARY LANDSCAPE;WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP411_r117160","Transcription factor","R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167172 Transcription of the HIV genome;R-HSA-5663205 Infectious disease;R-HSA-72086 mRNA Capping;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-167160;https://reactome.org/PathwayBrowser/#/R-HSA-167172;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-72086;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-77075;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O75027","Iron-sulfur clusters transporter ABCB7"," mitochondrial OS=Homo sapiens OX=9606 GN=ABCB7 PE=1 SV=2","ABCB7",0.824029171,0.008270916,"down",22595.5,21716.3,20025,18144.9,17093.6,17776.9,1.155265943,1.11031408,1.023841053,0.927715032,0.873964016,0.908899876,"plasma membrane","K05662","ABCB7; ATP-binding cassette"," subfamily B (MDR/TAP)"," member 7","hsa02010 ABC transporters","GO:0006790 sulfur compound metabolic process; GO:0006810 transport; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006879 cellular iron ion homeostasis; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0015886 heme transport; GO:0016043 cellular component organization; GO:0016226 iron-sulfur cluster assembly; GO:0019725 cellular homeostasis; GO:0022607 cellular component assembly; GO:0030003 cellular cation homeostasis; GO:0031163 metallo-sulfur cluster assembly; GO:0042592 homeostatic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0046916 cellular transition metal ion homeostasis; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055065 metal ion homeostasis; GO:0055072 iron ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0098771 inorganic ion homeostasis; GO:1901678 iron coordination entity transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0015232 heme transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00005","PF00005 ABC transporter","U","KOG0057","Mitochondrial Fe/S cluster exporter"," ABC superfamily",{"$nulls":3},"R-HSA-1369007 Mitochondrial ABC transporters;R-HSA-1430728 Metabolism;R-HSA-2564830 Cytosolic iron-sulfur cluster assembly;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-1369007;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-2564830;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-382556","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O75037","Kinesin-like protein KIF21B OS=Homo sapiens OX=9606 GN=KIF21B PE=1 SV=2","KIF21B",0.720251668,0.064687848,"nochange",7184.57,8473.8,8049.01,5547.13,4527,7001.15,1.057003638,1.246676897,1.184181218,0.816101255,0.666018352,1.03001864,"nucleus","K24185",null,null,"GO:0006928 movement of cell or subcellular component; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0009987 cellular process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005871 kinesin complex; GO:0005875 microtubule associated complex; GO:0005886 plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery;","GO:0003774 cytoskeletal motor activity; GO:0003777 microtubule motor activity; GO:0003824 catalytic activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity;","PF00225","PF00225 Kinesin motor domain","Z","KOG0244","Kinesin-like protein",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-983189 Kinesins;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-983189;https://reactome.org/PathwayBrowser/#/R-HSA-983231"]
["O75044","SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3","SRGAP2",1.11472866,0.198999925,"nochange",9506.13,7590.75,7771.71,9121.45,9583.2,9017.08,1.08454902,0.866024394,0.886670018,1.040661095,1.093341893,1.028753581,"nucleus","K07526","SRGAP; SLIT-ROBO Rho GTPase activating protein","hsa04360 Axon guidance","GO:0000226 microtubule cytoskeleton organization; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001667 ameboidal-type cell migration; GO:0003363 lamellipodium assembly involved in ameboidal cell migration; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007155 cell adhesion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008347 glial cell migration; GO:0009653 anatomical structure morphogenesis; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021795 cerebral cortex cell migration; GO:0021799 cerebral cortex radially oriented cell migration; GO:0021801 cerebral cortex radial glia-guided migration; GO:0021814 cell motility involved in cerebral cortex radial glia guided migration; GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration; GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration; GO:0021885 forebrain cell migration; GO:0021987 cerebral cortex development; GO:0022008 neurogenesis; GO:0022029 telencephalon cell migration; GO:0022030 telencephalon glial cell migration; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030032 lamellipodium assembly; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030900 forebrain development; GO:0031175 neuron projection development; GO:0031268 pseudopodium organization; GO:0031269 pseudopodium assembly; GO:0031589 cell-substrate adhesion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0034446 substrate adhesion-dependent cell spreading; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042063 gliogenesis; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0046847 filopodium assembly; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051014 actin filament severing; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051093 negative regulation of developmental process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051674 localization of cell; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060996 dendritic spine development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0097581 lamellipodium organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1902531 regulation of intracellular signal transduction; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2001222 regulation of neuron migration; GO:2001223 negative regulation of neuron migration;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030139 endocytic vesicle; GO:0030425 dendrite; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044309 neuron spine; GO:0044327 dendritic spine head; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0045335 phagocytic vesicle; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection;","GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00620; PF00018","PF00620 RhoGAP domain; PF00018 SH3 domain","Z","KOG3565","Cdc42-interacting protein CIP4",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-376176 Signaling by ROBO receptors;R-HSA-422475 Axon guidance;R-HSA-428543 Inactivation of CDC42 and RAC1;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9035034 RHOF GTPase cycle;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-428543;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9035034;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Homo sapiens OX=9606 GN=NOS1AP PE=1 SV=3","NOS1AP",1.307192544,0.290613879,"nochange",4377.02,8289.5,3687.36,7301.73,5881.09,8194.85,0.696025475,1.318180674,0.586357041,1.161107349,0.935199853,1.303129609,"nucleus","K16513","NOS1AP; carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein","hsa04713 Circadian entrainment","GO:0001505 regulation of neurotransmitter levels; GO:0002027 regulation of heart rate; GO:0003062 regulation of heart rate by chemical signal; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006937 regulation of muscle contraction; GO:0006942 regulation of striated muscle contraction; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008016 regulation of heart contraction; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010749 regulation of nitric oxide mediated signal transduction; GO:0010750 positive regulation of nitric oxide mediated signal transduction; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010941 regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023061 signal release; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030239 myofibril assembly; GO:0031032 actomyosin structure organization; GO:0031099 regeneration; GO:0031102 neuron projection regeneration; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032768 regulation of monooxygenase activity; GO:0032770 positive regulation of monooxygenase activity; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0033554 cellular response to stress; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042391 regulation of membrane potential; GO:0042592 homeostatic process; GO:0042692 muscle cell differentiation; GO:0043085 positive regulation of catalytic activity; GO:0043266 regulation of potassium ion transport; GO:0043268 positive regulation of potassium ion transport; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045214 sarcomere organization; GO:0045428 regulation of nitric oxide biosynthetic process; GO:0045429 positive regulation of nitric oxide biosynthetic process; GO:0045760 positive regulation of action potential; GO:0045823 positive regulation of heart contraction; GO:0045933 positive regulation of muscle contraction; GO:0045989 positive regulation of striated muscle contraction; GO:0046662 regulation of oviposition; GO:0046716 muscle cell cellular homeostasis; GO:0046903 secretion; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050896 response to stimulus; GO:0050999 regulation of nitric-oxide synthase activity; GO:0051000 positive regulation of nitric-oxide synthase activity; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051341 regulation of oxidoreductase activity; GO:0051353 positive regulation of oxidoreductase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051924 regulation of calcium ion transport; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0055117 regulation of cardiac muscle contraction; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060306 regulation of membrane repolarization; GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization; GO:0060452 positive regulation of cardiac muscle contraction; GO:0060548 negative regulation of cell death; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0086004 regulation of cardiac muscle cell contraction; GO:0090257 regulation of muscle system process; GO:0097435 supramolecular fiber organization; GO:0098900 regulation of action potential; GO:0098901 regulation of cardiac muscle cell action potential; GO:0098903 regulation of membrane repolarization during action potential; GO:0098911 regulation of ventricular cardiac muscle cell action potential; GO:0098916 anterograde trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099623 regulation of cardiac muscle cell membrane repolarization; GO:0099643 signal release from synapse; GO:0120036 plasma membrane bounded cell projection organization; GO:1901016 regulation of potassium ion transmembrane transporter activity; GO:1901018 positive regulation of potassium ion transmembrane transporter activity; GO:1901019 regulation of calcium ion transmembrane transporter activity; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901379 regulation of potassium ion transmembrane transport; GO:1901381 positive regulation of potassium ion transmembrane transport; GO:1901385 regulation of voltage-gated calcium channel activity; GO:1901841 regulation of high voltage-gated calcium channel activity; GO:1902259 regulation of delayed rectifier potassium channel activity; GO:1902261 positive regulation of delayed rectifier potassium channel activity; GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903115 regulation of actin filament-based movement; GO:1903116 positive regulation of actin filament-based movement; GO:1903169 regulation of calcium ion transmembrane transport; GO:1903426 regulation of reactive oxygen species biosynthetic process; GO:1903428 positive regulation of reactive oxygen species biosynthetic process; GO:1903522 regulation of blood circulation; GO:1903524 positive regulation of blood circulation; GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; GO:1903762 positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; GO:1903818 positive regulation of voltage-gated potassium channel activity; GO:1903947 positive regulation of ventricular cardiac muscle cell action potential; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1904407 positive regulation of nitric oxide metabolic process; GO:1905024 regulation of membrane repolarization during ventricular cardiac muscle cell action potential; GO:1905026 positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential; GO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential; GO:1905033 positive regulation of membrane repolarization during cardiac muscle cell action potential; GO:2000169 regulation of peptidyl-cysteine S-nitrosylation; GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation; GO:2000241 regulation of reproductive process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process; GO:2001257 regulation of cation channel activity; GO:2001259 positive regulation of cation channel activity;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016010 dystrophin-associated glycoprotein complex; GO:0016020 membrane; GO:0016528 sarcoplasm; GO:0016529 sarcoplasmic reticulum; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031674 I band; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0033017 sarcoplasmic reticulum membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0048471 perinuclear region of cytoplasm; GO:0055120 striated muscle dense body; GO:0071944 cell periphery; GO:0090665 glycoprotein complex; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0120025 plasma membrane bounded cell projection;","GO:0002020 protease binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008307 structural constituent of muscle; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030165 PDZ domain binding; GO:0030234 enzyme regulator activity; GO:0030235 nitric-oxide synthase regulator activity; GO:0050998 nitric-oxide synthase binding; GO:0098772 molecular function regulator;","PF00640","PF00640 Phosphotyrosine interaction domain (PTB/PID)","R","KOG4815","Muscular protein implicated in muscular dystrophy phenotype","WP706 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS","http://www.wikipathways.org/instance/WP706_r117178"]
["O75054","Immunoglobulin superfamily member 3 OS=Homo sapiens OX=9606 GN=IGSF3 PE=2 SV=3","IGSF3",0.900197625,0.548078124,"nochange",2514.22,3657.47,3720.76,2927.25,3316.06,2661.85,0.80251266,1.167426072,1.187627576,0.934347505,1.05845158,0.849634608,"plasma membrane","K06522",null,null,"GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0009987 cellular process; GO:0023052 signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032808 lacrimal gland development; GO:0035272 exocrine system development; GO:0048513 animal organ development; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation;","GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0071944 cell periphery;",null,"PF07686","PF07686 Immunoglobulin V-set domain",{"$nulls":8},"HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O75061","Putative tyrosine-protein phosphatase auxilin OS=Homo sapiens OX=9606 GN=DNAJC6 PE=1 SV=3","DNAJC6",1.189592186,0.027572854,"nochange",14304.2,15304.6,16679.5,17404.7,18850.8,18808.7,0.846799043,0.906022052,0.987415209,1.030346563,1.115954713,1.113462421,"nucleus","K09526","DNAJC6; DnaJ homolog subfamily C member 6","hsa04144 Endocytosis","GO:0006810 transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016191 synaptic vesicle uncoating; GO:0016192 vesicle-mediated transport; GO:0022411 cellular component disassembly; GO:0030100 regulation of endocytosis; GO:0032879 regulation of localization; GO:0032984 protein-containing complex disassembly; GO:0036465 synaptic vesicle recycling; GO:0043933 protein-containing complex organization; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048488 synaptic vesicle endocytosis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051261 protein depolymerization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0072318 clathrin coat disassembly; GO:0072319 vesicle uncoating; GO:0098657 import into cell; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:2000369 regulation of clathrin-dependent endocytosis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0014069 postsynaptic density; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0045202 synapse; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization;",null,"PF10409; PF00226","PF10409 C2 domain of PTEN tumour-suppressor protein; PF00226 DnaJ domain","TR","KOG2283","Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432720;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828"]
["O75063","Glycosaminoglycan xylosylkinase OS=Homo sapiens OX=9606 GN=FAM20B PE=1 SV=1","FAM20B",1.70927795,{"v":7.35132e-05,"d":"7.35E-05"},"up",29488.1,28000.2,27471.2,49276.7,46142.7,49800,0.768656901,0.729872286,0.716083012,1.284480028,1.20278705,1.298120723,"extracellular","K20825",null,null,"GO:0001501 skeletal system development; GO:0006029 proteoglycan metabolic process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0016310 phosphorylation; GO:0019538 protein metabolic process; GO:0030166 proteoglycan biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048513 animal organ development; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048598 embryonic morphogenesis; GO:0048701 embryonic cranial skeleton morphogenesis; GO:0048704 embryonic skeletal system morphogenesis; GO:0048705 skeletal system morphogenesis; GO:0048706 embryonic skeletal system development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1904888 cranial skeletal system development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0140096 catalytic activity"," acting on a protein;",null,null,"S","KOG3829","Uncharacterized conserved protein"]
["O75069","Transmembrane and coiled-coil domains protein 2 OS=Homo sapiens OX=9606 GN=TMCC2 PE=1 SV=3","TMCC2",2.997512778,0.000261035,"up",4814.03,3790.99,4542.18,14061.6,11763.7,13583.6,0.549587584,0.432793529,0.518552176,1.605324596,1.342987779,1.550754337,"plasma membrane",{"$nulls":3},"GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0042982 amyloid precursor protein metabolic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044238 primary metabolic process; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051291 protein heterooligomerization; GO:0060322 head development; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005791 rough endoplasmic reticulum; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity;",null,null,"S","KOG3850","Predicted membrane protein",{"$nulls":5},"HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["O75081","Protein CBFA2T3 OS=Homo sapiens OX=9606 GN=CBFA2T3 PE=1 SV=2","CBFA2T3",0.537834407,0.002972432,"down",18051.4,22968.2,20896,9770.64,11303,12226.7,1.137502817,1.447333293,1.316754317,0.615693549,0.712254692,0.770461332,"nucleus","K22752",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001666 response to hypoxia; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0006091 generation of precursor metabolites and energy; GO:0006109 regulation of carbohydrate metabolic process; GO:0006110 regulation of glycolytic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010677 negative regulation of cellular carbohydrate metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030809 negative regulation of nucleotide biosynthetic process; GO:0030811 regulation of nucleotide catabolic process; GO:0030812 negative regulation of nucleotide catabolic process; GO:0030851 granulocyte differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0036293 response to decreased oxygen levels; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043457 regulation of cellular respiration; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043470 regulation of carbohydrate catabolic process; GO:0044237 cellular metabolic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045598 regulation of fat cell differentiation; GO:0045599 negative regulation of fat cell differentiation; GO:0045732 positive regulation of protein catabolic process; GO:0045820 negative regulation of glycolytic process; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045912 negative regulation of carbohydrate metabolic process; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045980 negative regulation of nucleotide metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0062012 regulation of small molecule metabolic process; GO:0062014 negative regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0080090 regulation of primary metabolic process; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900372 negative regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1900543 negative regulation of purine nucleotide metabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903578 regulation of ATP metabolic process; GO:1903579 negative regulation of ATP metabolic process; GO:1903715 regulation of aerobic respiration; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001169 regulation of ATP biosynthetic process; GO:2001170 negative regulation of ATP biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0016363 nuclear matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0140110 transcription regulator activity;","PF08788; PF01753","PF08788 NHR2 domain like; PF01753 MYND finger",{"$nulls":3},"WP2849 HEMATOPOIETIC STEM CELL DIFFERENTIATION","http://www.wikipathways.org/instance/WP2849_r117150","Transcription factor",null,null,"ESTROGEN RESPONSE EARLY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY"]
["O75083","WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4","WDR1",1.077169278,0.000950889,"nochange",586618,573398,579653,630897,619275,623746,0.974020551,0.952070062,0.962455864,1.047541404,1.028244235,1.035667883,"cytoplasm","K24736",null,null,"GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001667 ameboidal-type cell migration; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002165 instar larval or pupal development; GO:0002252 immune effector process; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002520 immune system development; GO:0002576 platelet degranulation; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007043 cell-cell junction assembly; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008154 actin polymerization or depolymerization; GO:0008360 regulation of cell shape; GO:0008544 epidermis development; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009913 epidermal cell differentiation; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010927 cellular component assembly involved in morphogenesis; GO:0014013 regulation of gliogenesis; GO:0014866 skeletal myofibril assembly; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016333 morphogenesis of follicular epithelium; GO:0016334 establishment or maintenance of polarity of follicular epithelium; GO:0016477 cell migration; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030011 maintenance of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030042 actin filament depolymerization; GO:0030043 actin filament fragmentation; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030220 platelet formation; GO:0030239 myofibril assembly; GO:0030240 skeletal muscle thin filament assembly; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030834 regulation of actin filament depolymerization; GO:0030836 positive regulation of actin filament depolymerization; GO:0030837 negative regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0031032 actomyosin structure organization; GO:0031333 negative regulation of protein-containing complex assembly; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032984 protein-containing complex disassembly; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation; GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035090 maintenance of apical/basal cell polarity; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035315 hair cell differentiation; GO:0035316 non-sensory hair organization; GO:0035317 imaginal disc-derived wing hair organization; GO:0036344 platelet morphogenesis; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0042247 establishment of planar polarity of follicular epithelium; GO:0042391 regulation of membrane potential; GO:0042692 muscle cell differentiation; GO:0043243 positive regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043269 regulation of ion transport; GO:0043297 apical junction assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045199 maintenance of epithelial cell apical/basal polarity; GO:0045214 sarcomere organization; GO:0045216 cell-cell junction organization; GO:0045595 regulation of cell differentiation; GO:0045685 regulation of glial cell differentiation; GO:0046903 secretion; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048713 regulation of oligodendrocyte differentiation; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050900 leukocyte migration; GO:0050954 sensory perception of mechanical stimulus; GO:0051049 regulation of transport; GO:0051125 regulation of actin nucleation; GO:0051126 negative regulation of actin nucleation; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051261 protein depolymerization; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051960 regulation of nervous system development; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0060284 regulation of cell development; GO:0060306 regulation of membrane repolarization; GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070925 organelle assembly; GO:0071689 muscle thin filament assembly; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097435 supramolecular fiber organization; GO:0097529 myeloid leukocyte migration; GO:0097530 granulocyte migration; GO:0099623 regulation of cardiac muscle cell membrane repolarization; GO:0110053 regulation of actin filament organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901879 regulation of protein depolymerization; GO:1901881 positive regulation of protein depolymerization; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1990266 neutrophil migration; GO:2000026 regulation of multicellular organismal development;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016528 sarcoplasm; GO:0030016 myofibril; GO:0030054 cell junction; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0042641 actomyosin; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;",null,null,"Z","KOG0318","WD40 repeat stress protein/actin interacting protein","WP516 HYPERTROPHY MODEL","http://www.wikipathways.org/instance/WP516_r117755",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005","COAGULATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COAGULATION"]
["O75113","NEDD4-binding protein 1 OS=Homo sapiens OX=9606 GN=N4BP1 PE=1 SV=4","N4BP1",0.694055305,0.006692411,"down",6710.88,6591.07,7478.93,4639.95,5372.87,4410.26,1.143771326,1.123351464,1.274674213,0.790811602,0.915727094,0.751664301,"cytoplasm",{"$nulls":3},"GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0019222 regulation of metabolic process; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0034644 cellular response to UV; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0045861 negative regulation of proteolysis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0080090 regulation of primary metabolic process; GO:0104004 cellular response to environmental stimulus; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0016604 nuclear body; GO:0016605 PML body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",null,"PF11977","PF11977 Zc3h12a-like Ribonuclease NYN domain","S","KOG3777","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation  ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-9020702 Interleukin-1 signaling;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-9758274 Regulation of NF-kappa B signaling;R-HSA-975871 MyD88 cascade initiated on plasma membrane","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-166016;https://reactome.org/PathwayBrowser/#/R-HSA-166058;https://reactome.org/PathwayBrowser/#/R-HSA-166166;https://reactome.org/PathwayBrowser/#/R-HSA-168138;https://reactome.org/PathwayBrowser/#/R-HSA-168142;https://reactome.org/PathwayBrowser/#/R-HSA-168164;https://reactome.org/PathwayBrowser/#/R-HSA-168176;https://reactome.org/PathwayBrowser/#/R-HSA-168179;https://reactome.org/PathwayBrowser/#/R-HSA-168181;https://reactome.org/PathwayBrowser/#/R-HSA-168188;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168898;https://reactome.org/PathwayBrowser/#/R-HSA-181438;https://reactome.org/PathwayBrowser/#/R-HSA-445989;https://reactome.org/PathwayBrowser/#/R-HSA-446652;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-9020702;https://reactome.org/PathwayBrowser/#/R-HSA-937061;https://reactome.org/PathwayBrowser/#/R-HSA-975138;https://reactome.org/PathwayBrowser/#/R-HSA-975155;https://reactome.org/PathwayBrowser/#/R-HSA-9758274;https://reactome.org/PathwayBrowser/#/R-HSA-975871"]
["O75116","Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4","ROCK2",1.201171371,0.002844778,"up",27147.2,27153.1,26357.3,33157.9,33099.7,30626,0.917438882,0.917638272,0.890744233,1.120570324,1.118603457,1.035004833,"nucleus","K17388","ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.1]","hsa04510 Focal adhesion; hsa04270 Vascular smooth muscle contraction; hsa04921 Oxytocin signaling pathway; hsa04360 Axon guidance; hsa05200 Pathways in cancer; hsa05131 Shigellosis; hsa04310 Wnt signaling pathway; hsa05132 Salmonella infection; hsa04670 Leukocyte transendothelial migration; hsa05205 Proteoglycans in cancer; hsa04071 Sphingolipid signaling pathway; hsa05135 Yersinia infection; hsa04062 Chemokine signaling pathway; hsa05163 Human cytomegalovirus infection; hsa04530 Tight junction; hsa04810 Regulation of actin cytoskeleton; hsa04024 cAMP signaling pathway; hsa05130 Pathogenic Escherichia coli infection; hsa04611 Platelet activation; hsa05417 Lipid and atherosclerosis; hsa04022 cGMP-PKG signaling pathway",{"$cut":{"chars":27599,"head":"GO:0000003 reproduction; GO:0000022 mitotic spindle elongation; GO:0000070 mitotic sister chromatid segregation; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000281 mitotic cytokinesis; GO:0000819 sister chromatid segregation; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0000910 cytokinesis; GO:0001654 eye development; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001736 establishment of planar polarity; GO:0001737 establishment of imaginal disc-derived wing hair orientation; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001775 cell activation; GO:0001816 cytokine production; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001952 regulation of cell-matrix adhesion; GO:0001954 positive regulation of cell-matrix adhesion; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003012 muscle system process; GO:0003381 epithelial cell morphogenesis involved in gastrulation; GO:0003382 epithelial cell morphogenesis; GO:0003383 apical constriction; GO:0003384 apical constriction involved in gastrulation; GO:0006323 DNA packaging; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006936 muscle contraction; GO:0006939 smooth muscle contraction; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0007097 nuclear migration; GO:0007098 centrosome cycle; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007159 leukocyte cell-cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007249 I-kappaB kinase/NF-kappaB signaling; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007266 Rho protein signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007300 ovarian nurse cell to oocyte transport; GO:0007302 nurse cell nucleus anchoring; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007369 gastrulation; GO:0007389 pattern specification process; GO:0007391 dorsal closure; GO:0007399 nervous system developm"}}," planar cell polarity pathway; GO:2000114 regulation of establishment of cell polarity; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2000810 regulation of bicellular tight junction assembly;","GO:0000922 spindle pole; GO:0001726 ruffle; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0005938 cell cortex; GO:0010494 cytoplasmic stress granule; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030141 secretory granule; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031616 spindle pole centrosome; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0044291 cell-cell contact zone; GO:0045177 apical part of cell; GO:0045179 apical cortex; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0106037 apicomedial cortex; GO:0120025 plasma membrane bounded cell projection; GO:1990904 ribonucleoprotein complex;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0051020 GTPase binding; GO:0072518 Rho-dependent protein serine/threonine kinase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00069","PF00069 Protein kinase domain","T","KOG0612","Rho-associated"," coiled-coil containing protein kinase","WP4962 AIRWAY SMOOTH MUSCLE CELL CONTRACTION;WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY;WP3929 CHEMOKINE SIGNALING PATHWAY;WP3594 CIRCADIAN RHYTHM GENES;WP306 FOCAL ADHESION;WP524 G13 SIGNALING PATHWAY;WP185 INTEGRINMEDIATED CELL ADHESION;WP2034 LEPTIN SIGNALING PATHWAY;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION;WP3680 PHYSICOCHEMICAL FEATURES AND TOXICITYASSOCIATED PATHWAYS;WP51 REGULATION OF ACTIN CYTOSKELETON;WP2431 SPINAL CORD INJURY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY;WP428 WNT SIGNALING","http://www.wikipathways.org/instance/WP4962_r120588;http://www.wikipathways.org/instance/WP138_r120688;http://www.wikipathways.org/instance/WP3929_r119247;http://www.wikipathways.org/instance/WP3594_r117682;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP524_r117113;http://www.wikipathways.org/instance/WP185_r116785;http://www.wikipathways.org/instance/WP2034_r120670;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP2272_r118427;http://www.wikipathways.org/instance/WP3680_r117651;http://www.wikipathways.org/instance/WP51_r116716;http://www.wikipathways.org/instance/WP2431_r117177;http://www.wikipathways.org/instance/WP3888_r116782;http://www.wikipathways.org/instance/WP428_r116549",null,"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-194138 Signaling by VEGF;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-372790 Signaling by GPCR;R-HSA-373755 Semaphorin interactions;R-HSA-388396 GPCR downstream signalling;R-HSA-3928662 EPHB-mediated forward signaling;R-HSA-3928663 EPHA-mediated growth cone collapse;R-HSA-400685 Sema4D in semaphorin signaling;R-HSA-416482 G alpha (12/13) signalling events;R-HSA-416572 Sema4D induced cell migration and growth-cone collapse;R-HSA-422475 Axon guidance;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-5627117 RHO GTPases Activate ROCKs;R-HSA-5663205 Infectious disease;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013407 RHOH GTPase cycle;R-HSA-9013422 RHOBTB1 GTPase cycle;R-HSA-9675108 Nervous system development;R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections;R-HSA-9706574 RHOBTB GTPase Cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-373755;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-3928662;https://reactome.org/PathwayBrowser/#/R-HSA-3928663;https://reactome.org/PathwayBrowser/#/R-HSA-400685;https://reactome.org/PathwayBrowser/#/R-HSA-416482;https://reactome.org/PathwayBrowser/#/R-HSA-416572;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-4420097;https://reactome.org/PathwayBrowser/#/R-HSA-5627117;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013407;https://reactome.org/PathwayBrowser/#/R-HSA-9013422;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9679191;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9706574;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O75122","CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3","CLASP2",0.935662135,{"v":6.60409e-05,"d":"6.60E-05"},"nochange",14668.9,14723,14834,13756.2,13777,13847.3,1.028117057,1.031908829,1.039688621,0.96414754,0.965605375,0.970532577,"cytoplasm","K16578",null,null,"GO:0000003 reproduction; GO:0000022 mitotic spindle elongation; GO:0000070 mitotic sister chromatid segregation; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001558 regulation of cell growth; GO:0001578 microtubule bundle formation; GO:0001952 regulation of cell-matrix adhesion; GO:0001953 negative regulation of cell-matrix adhesion; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006903 vesicle targeting; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007020 microtubule nucleation; GO:0007026 negative regulation of microtubule depolymerization; GO:0007030 Golgi organization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0007080 mitotic metaphase plate congression; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007282 cystoblast division; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007308 oocyte construction; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0008104 protein localization; GO:0008356 asymmetric cell division; GO:0008361 regulation of cell size; GO:0008608 attachment of spindle microtubules to kinetochore; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010256 endomembrane system organization; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010458 exit from mitosis; GO:0010470 regulation of gastrulation; GO:0010564 regulation of cell cycle process; GO:0010632 regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010715 regulation of extracellular matrix disassembly; GO:0010717 regulation of epithelial to mesenchymal transition; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0010975 regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016325 oocyte microtubule cytoskeleton organization; GO:0016477 cell migration; GO:0017157 regulation of exocytosis; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022406 membrane docking; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030010 establishment of cell polarity; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030516 regulation of axon extension; GO:0030723 ovarian fusome organization; GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity; GO:0030952 establishment or maintenance of cytoskeleton polarity; GO:0030953 astral microtubule organization; GO:0031023 microtubule organizing center organization; GO:0031109 microtubule polymerization or depolymerization; GO:0031110 regulation of microtubule polymerization or depolymerization; GO:0031111 negative regulation of microtubule polymerization or depolymerization; GO:0031112 positive regulation of microtubule polymerization or depolymerization; GO:0031113 regulation of microtubule polymerization; GO:0031114 regulation of microtubule depolymerization; GO:0031116 positive regulation of microtubule polymerization; GO:0031122 cytoplasmic microtubule organization; GO:0031175 neuron projection development; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032231 regulation of actin filament bundle assembly; GO:0032232 negative regulation of actin filament bundle assembly; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034453 microtubule anchoring; GO:0034613 cellular protein localization; GO:0035099 hemocyte migration; GO:0035162 embryonic hemopoiesis; GO:0035791 platelet-derived growth factor receptor-beta signaling pathway; GO:0040001 establishment of mitotic spindle localization; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0040019 positive regulation of embryonic development; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043242 negative regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044782 cilium organization; GO:0044839 cell cycle G2/M phase transition; GO:0045478 fusome organization; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045921 positive regulation of exocytosis; GO:0045995 regulation of embryonic development; GO:0046578 regulation of Ras protein signal transduction; GO:0046580 negative regulation of Ras protein signal transduction; GO:0046602 regulation of mitotic centrosome separation; GO:0046605 regulation of centrosome cycle; GO:0046785 microtubule polymerization; GO:0048008 platelet-derived growth factor receptor signaling pathway; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048568 embryonic organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050000 chromosome localization; GO:0050767 regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051058 negative regulation of small GTPase mediated signal transduction; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051231 spindle elongation; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051258 protein polymerization; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051301 cell division; GO:0051303 establishment of chromosome localization; GO:0051310 metaphase plate congression; GO:0051315 attachment of mitotic spindle microtubules to kinetochore; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051497 negative regulation of stress fiber assembly; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051893 regulation of focal adhesion assembly; GO:0051895 negative regulation of focal adhesion assembly; GO:0051960 regulation of nervous system development; GO:0060271 cilium assembly; GO:0060284 regulation of cell development; GO:0060627 regulation of vesicle-mediated transport; GO:0061041 regulation of wound healing; GO:0061045 negative regulation of wound healing; GO:0061387 regulation of extent of cell growth; GO:0061564 axon development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080134 regulation of response to stress; GO:0090066 regulation of anatomical structure size; GO:0090091 positive regulation of extracellular matrix disassembly; GO:0090109 regulation of cell-substrate junction assembly; GO:0090162 establishment of epithelial cell polarity; GO:0090307 mitotic spindle assembly; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0097711 ciliary basal body-plasma membrane docking; GO:0098727 maintenance of cell number; GO:0098813 nuclear chromosome segregation; GO:0110011 regulation of basement membrane organization; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140014 mitotic nuclear division; GO:0140056 organelle localization by membrane tethering; GO:1901879 regulation of protein depolymerization; GO:1901880 negative regulation of protein depolymerization; GO:1901888 regulation of cell junction assembly; GO:1901889 negative regulation of cell junction assembly; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903034 regulation of response to wounding; GO:1903035 negative regulation of response to wounding; GO:1903047 mitotic cell cycle process; GO:1903053 regulation of extracellular matrix organization; GO:1903055 positive regulation of extracellular matrix organization; GO:1903391 regulation of adherens junction organization; GO:1903392 negative regulation of adherens junction organization; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903689 regulation of wound healing"," spreading of epidermal cells; GO:1903690 negative regulation of wound healing"," spreading of epidermal cells; GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis; GO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis; GO:1905330 regulation of morphogenesis of an epithelium; GO:1905331 negative regulation of morphogenesis of an epithelium; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000922 spindle pole; GO:0001726 ruffle; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005827 polar microtubule; GO:0005828 kinetochore microtubule; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005876 spindle microtubule; GO:0005881 cytoplasmic microtubule; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0030863 cortical cytoskeleton; GO:0030981 cortical microtubule cytoskeleton; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031592 centrosomal corona; GO:0031984 organelle subcompartment; GO:0032587 ruffle membrane; GO:0032991 protein-containing complex; GO:0035371 microtubule plus-end; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044295 axonal growth cone; GO:0045169 fusome; GO:0045171 intercellular bridge; GO:0045172 germline ring canal; GO:0045178 basal part of cell; GO:0045180 basal cortex; GO:0055028 cortical microtubule; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0098687 chromosomal region; GO:0098791 Golgi apparatus subcompartment; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1903754 cortical microtubule plus-end; GO:1904511 cytoplasmic microtubule plus-end; GO:1990752 microtubule end;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0002162 dystroglycan binding; GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005525 GTP binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0017076 purine nucleotide binding; GO:0019001 guanyl nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043515 kinetochore binding; GO:0044877 protein-containing complex binding; GO:0051010 microtubule plus-end binding; GO:0051015 actin filament binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990782 protein tyrosine kinase binding;",null,null,"R","KOG2956","CLIP-associating protein","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4932_r118797",null,"R-HSA-1266738 Developmental Biology;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-376176 Signaling by ROBO receptors;R-HSA-422475 Axon guidance;R-HSA-428890 Role of ABL in ROBO-SLIT signaling;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-141424;https://reactome.org/PathwayBrowser/#/R-HSA-141444;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2500257;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-428890;https://reactome.org/PathwayBrowser/#/R-HSA-5663220;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69618;https://reactome.org/PathwayBrowser/#/R-HSA-69620;https://reactome.org/PathwayBrowser/#/R-HSA-9648025;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["O75127","Pentatricopeptide repeat-containing protein 1"," mitochondrial OS=Homo sapiens OX=9606 GN=PTCD1 PE=1 SV=2","PTCD1",0.818873113,0.052895474,"nochange",12224.4,13032,12381.8,10698.7,11256.1,8866.11,1.071389914,1.142170852,1.08518501,0.937672137,0.986524657,0.777057429,"mitochondria","K17710",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0031123 RNA 3'-end processing; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042780 tRNA 3'-end processing; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043628 ncRNA 3'-end processing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000049 tRNA binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0005488 binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG4197","FOG: PPR repeat"]
["O75131","Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1","CPNE3",1.271982894,1.376391E-3,"up",12776.9,13178.9,12392.2,16966.9,16229.7,15581.4,0.879891192,0.907575236,0.853398526,1.168438813,1.117670959,1.073025274,"extracellular","K24524",null,null,"GO:0000902 cell morphogenesis; GO:0001775 cell activation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001961 positive regulation of cytokine-mediated signaling pathway; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006508 proteolysis; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0038127 ERBB signaling pathway; GO:0038128 ERBB2 signaling pathway; GO:0040007 growth; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043392 negative regulation of DNA binding; GO:0043412 macromolecule modification; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046903 secretion; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051101 regulation of DNA binding; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051592 response to calcium ion; GO:0051716 cellular response to stimulus; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060560 developmental growth involved in morphogenesis; GO:0060759 regulation of response to cytokine stimulus; GO:0060760 positive regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071277 cellular response to calcium ion; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090407 organophosphate biosynthetic process; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901223 negative regulation of NIK/NF-kappaB signaling; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway; GO:1990138 neuron projection extension; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0035577 azurophil granule membrane; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0001786 phosphatidylserine binding; GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005102 signaling receptor binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005544 calcium-dependent phospholipid binding; GO:0008134 transcription factor binding; GO:0008233 peptidase activity; GO:0008289 lipid binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016787 hydrolase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030971 receptor tyrosine kinase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046983 protein dimerization activity; GO:0048306 calcium-dependent protein binding; GO:0051059 NF-kappaB binding; GO:0072341 modified amino acid binding; GO:0140096 catalytic activity"," acting on a protein; GO:1990782 protein tyrosine kinase binding;","PF00168","PF00168 C2 domain","T","KOG1327","Copine",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483206 Glycerophospholipid biosynthesis;R-HSA-1483257 Phospholipid metabolism;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-556833 Metabolism of lipids;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483206;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O75132","Zinc finger BED domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZBED4 PE=1 SV=2","ZBED4",0.982425227,0.844328277,"nochange",3537.21,2899.87,3329.76,2768.75,3751.44,3075,1.096127834,0.898625816,1.031842219,0.857993712,1.162514468,0.952895952,"cytoplasm","K24640",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF02892; PF05699","PF02892 BED zinc finger; PF05699 hAT family C-terminal dimerisation region","L","KOG1121","Tam3-transposase (Ac family)",null,null,"Transcription factor"]
["O75140","GATOR complex protein DEPDC5 OS=Homo sapiens OX=9606 GN=DEPDC5 PE=1 SV=2","DEPDC5",0.807607201,0.19038886,"nochange",4064.43,3147.04,3838.06,3267.23,3332.03,2324.42,1.220964482,0.945378334,1.152962393,0.981483697,1.000949772,0.698261321,"nucleus","K20404","DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5","hsa04150 mTOR signaling pathway","GO:0000003 reproduction; GO:0003006 developmental process involved in reproduction; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007282 cystoblast division; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0008283 cell population proliferation; GO:0008356 asymmetric cell division; GO:0008361 regulation of cell size; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010506 regulation of autophagy; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030727 germarium-derived female germ-line cyst formation; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032006 regulation of TOR signaling; GO:0032007 negative regulation of TOR signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0033554 cellular response to stress; GO:0034198 cellular response to amino acid starvation; GO:0042594 response to starvation; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0044703 multi-organism reproductive process; GO:0045792 negative regulation of cell size; GO:0048134 germ-line cyst formation; GO:0048135 female germ-line cyst formation; GO:0048142 germarium-derived cystoblast division; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051301 cell division; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071496 cellular response to external stimulus; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903432 regulation of TORC1 signaling; GO:1904262 negative regulation of TORC1 signaling; GO:1990928 response to amino acid starvation;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0032991 protein-containing complex; GO:0035859 Seh1-associated complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:1990130 GATOR1 complex;","GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0008047 enzyme activator activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0044877 protein-containing complex binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00610","PF00610 Domain found in Dishevelled"," Egl-10"," and Pleckstrin (DEP)","T","KOG3572","Uncharacterized conserved protein"," contains DEP domain","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4657_r120007",null,"R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9639288 Amino acids regulate mTORC1;R-HSA-9711097 Cellular response to starvation","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9639288;https://reactome.org/PathwayBrowser/#/R-HSA-9711097"]
["O75143","Autophagy-related protein 13 OS=Homo sapiens OX=9606 GN=ATG13 PE=1 SV=1","ATG13",0.577768755,0.100549922,"nochange",2861.9,4760.94,3608.47,1315.45,2678.23,2495.42,0.969018211,1.612019135,1.221801301,0.445401658,0.906828905,0.844930789,"cytoplasm","K08331","ATG13; autophagy-related protein 13","hsa04215 Apoptosis - multiple species; hsa05017 Spinocerebellar ataxia; hsa04140 Autophagy - animal; hsa05016 Huntington disease; hsa05010 Alzheimer disease; hsa04211 Longevity regulating pathway; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis","GO:0000045 autophagosome assembly; GO:0000422 autophagy of mitochondrion; GO:0000423 mitophagy; GO:0001894 tissue homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002165 instar larval or pupal development; GO:0003008 system process; GO:0006914 autophagy; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007033 vacuole organization; GO:0007275 multicellular organism development; GO:0007552 metamorphosis; GO:0007586 digestion; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010623 programmed cell death involved in cell development; GO:0010669 epithelial structure maintenance; GO:0010720 positive regulation of cell development; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016236 macroautophagy; GO:0016241 regulation of macroautophagy; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022411 cellular component disassembly; GO:0022600 digestive system process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030277 maintenance of gastrointestinal epithelium; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0035069 larval midgut histolysis; GO:0035096 larval midgut cell programmed cell death; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0045477 regulation of nurse cell apoptotic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045850 positive regulation of nurse cell apoptotic process; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048707 instar larval or pupal morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0060033 anatomical structure regression; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060729 intestinal epithelial structure maintenance; GO:0061726 mitochondrion disassembly; GO:0061912 selective autophagy; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0098780 response to mitochondrial depolarisation; GO:1903008 organelle disassembly; GO:1904747 positive regulation of apoptotic process involved in development; GO:1904748 regulation of apoptotic process involved in development; GO:1905037 autophagosome organization; GO:1905879 regulation of oogenesis; GO:1905881 positive regulation of oogenesis; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process;","GO:0000407 phagophore assembly site; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex; GO:1990316 Atg1/ULK1 kinase complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019207 kinase regulator activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0098772 molecular function regulator;",null,null,"S","KOG3874","Uncharacterized conserved protein","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP4923 AUTOPHAGY;WP4863 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY;WP4577 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY;WP3844 PI3KAKTMTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP4923_r110416;http://www.wikipathways.org/instance/WP4863_r116597;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP5115_r120597;http://www.wikipathways.org/instance/WP4577_r118444;http://www.wikipathways.org/instance/WP3844_r107714",null,"R-HSA-1632852 Macroautophagy;R-HSA-9612973 Autophagy","https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-9612973"]
["O75145","Liprin-alpha-3 OS=Homo sapiens OX=9606 GN=PPFIA3 PE=1 SV=3","PPFIA3",0.535510629,0.000770314,"down",3268.91,3331.65,3586.39,1864.33,1608.73,1982.16,1.253883572,1.277949287,1.375662072,0.715116892,0.617074229,0.760313946,"nucleus",{"$nulls":3},"GO:0001505 regulation of neurotransmitter levels; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0009987 cellular process; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023061 signal release; GO:0031589 cell-substrate adhesion; GO:0032231 regulation of actin filament bundle assembly; GO:0032232 negative regulation of actin filament bundle assembly; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0044087 regulation of cellular component biogenesis; GO:0046903 secretion; GO:0048167 regulation of synaptic plasticity; GO:0048168 regulation of neuronal synaptic plasticity; GO:0048172 regulation of short-term neuronal synaptic plasticity; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051497 negative regulation of stress fiber assembly; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0098916 anterograde trans-synaptic signaling; GO:0099177 regulation of trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1903076 regulation of protein localization to plasma membrane; GO:1903077 negative regulation of protein localization to plasma membrane; GO:1903828 negative regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904376 negative regulation of protein localization to cell periphery; GO:1905475 regulation of protein localization to membrane; GO:1905476 negative regulation of protein localization to membrane;","GO:0001669 acrosomal vesicle; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0012505 endomembrane system; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0045202 synapse; GO:0048786 presynaptic active zone; GO:0070161 anchoring junction; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0098875 epididymosome; GO:0099503 secretory vesicle; GO:1903561 extracellular vesicle; GO:1990742 microvesicle;",null,"PF00536; PF07647","PF00536 SAM domain (Sterile alpha motif); PF07647 SAM domain (Sterile alpha motif)","R","KOG0249","LAR-interacting protein and related proteins",{"$nulls":3},"R-HSA-112310 Neurotransmitter release cycle;R-HSA-112315 Transmission across Chemical Synapses;R-HSA-112316 Neuronal System;R-HSA-181429 Serotonin Neurotransmitter Release Cycle;R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle;R-HSA-210500 Glutamate Neurotransmitter Release Cycle;R-HSA-212676 Dopamine Neurotransmitter Release Cycle;R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle;R-HSA-388844 Receptor-type tyrosine-protein phosphatases;R-HSA-6794362 Protein-protein interactions at synapses","https://reactome.org/PathwayBrowser/#/R-HSA-112310;https://reactome.org/PathwayBrowser/#/R-HSA-112315;https://reactome.org/PathwayBrowser/#/R-HSA-112316;https://reactome.org/PathwayBrowser/#/R-HSA-181429;https://reactome.org/PathwayBrowser/#/R-HSA-181430;https://reactome.org/PathwayBrowser/#/R-HSA-210500;https://reactome.org/PathwayBrowser/#/R-HSA-212676;https://reactome.org/PathwayBrowser/#/R-HSA-264642;https://reactome.org/PathwayBrowser/#/R-HSA-388844;https://reactome.org/PathwayBrowser/#/R-HSA-6794362"]
["O75146","Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2","HIP1R",0.742908095,0.005377796,"down",2280.99,2023.04,2032.42,1520.3,1499.55,1687.55,1.239236317,1.099094971,1.10419102,0.825961961,0.814688718,0.916827012,"mitochondria","K20040",null,null,"GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006915 apoptotic process; GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008219 cell death; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway; GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030100 regulation of endocytosis; GO:0030162 regulation of proteolysis; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030837 negative regulation of actin filament polymerization; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031503 protein-containing complex localization; GO:0031647 regulation of protein stability; GO:0032092 positive regulation of protein binding; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032594 protein transport within lipid bilayer; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation; GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation; GO:0034613 cellular protein localization; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043254 regulation of protein-containing complex assembly; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043393 regulation of protein binding; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044058 regulation of digestive system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045184 establishment of protein localization; GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway; GO:0045807 positive regulation of endocytosis; GO:0045862 positive regulation of proteolysis; GO:0046902 regulation of mitochondrial membrane permeability; GO:0046907 intracellular transport; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048268 clathrin coat assembly; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051125 regulation of actin nucleation; GO:0051126 negative regulation of actin nucleation; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051668 localization within membrane; GO:0051716 cellular response to stimulus; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0055123 digestive system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060453 regulation of gastric acid secretion; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090559 regulation of membrane permeability; GO:0097190 apoptotic signaling pathway; GO:0098657 import into cell; GO:0099632 protein transport within plasma membrane; GO:0099637 neurotransmitter receptor transport; GO:0110053 regulation of actin filament organization; GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; GO:1901184 regulation of ERBB signaling pathway; GO:1901186 positive regulation of ERBB signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1905443 regulation of clathrin coat assembly; GO:1905445 positive regulation of clathrin coat assembly; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000369 regulation of clathrin-dependent endocytosis; GO:2000370 positive regulation of clathrin-dependent endocytosis; GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway; GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005905 clathrin-coated pit; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030425 dendrite; GO:0030659 cytoplasmic vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030665 clathrin-coated vesicle membrane; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0032587 ruffle membrane; GO:0032838 plasma membrane bounded cell projection cytoplasm; GO:0032839 dendrite cytoplasm; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0044309 neuron spine; GO:0045177 apical part of cell; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099568 cytoplasmic region; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection; GO:0120111 neuron projection cytoplasm;","GO:0003779 actin binding; GO:0005102 signaling receptor binding; GO:0005154 epidermal growth factor receptor binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding; GO:0030276 clathrin binding; GO:0030674 protein-macromolecule adaptor activity; GO:0032051 clathrin light chain binding; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0035254 glutamate receptor binding; GO:0035612 AP-2 adaptor complex binding; GO:0035615 clathrin adaptor activity; GO:0038024 cargo receptor activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043325 phosphatidylinositol-3","4-bisphosphate binding; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0051015 actin filament binding; GO:0060090 molecular adaptor activity; GO:0070851 growth factor receptor binding; GO:0080025 phosphatidylinositol-3","5-bisphosphate binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF07651","PF07651 ANTH domain","Z","KOG0980","Actin-binding protein SLA2/Huntingtin-interacting protein Hip1",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828"]
["O75147","Obscurin-like protein 1 OS=Homo sapiens OX=9606 GN=OBSL1 PE=1 SV=4","OBSL1",0.600696023,{"v":2.81626E-5,"d":"2.82E-05"},"down",6991.33,7209.94,7004.93,4379,4288.09,4071.39,1.235774796,1.274415903,1.238178707,0.774024089,0.757955002,0.719651504,"nucleus","K19574",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0003008 system process; GO:0003012 muscle system process; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006936 muscle contraction; GO:0006941 striated muscle contraction; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007030 Golgi organization; GO:0007088 regulation of mitotic nuclear division; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007507 heart development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010564 regulation of cell cycle process; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014706 striated muscle tissue development; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030239 myofibril assembly; GO:0031032 actomyosin structure organization; GO:0031033 myosin filament organization; GO:0031034 myosin filament assembly; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0034067 protein localization to Golgi apparatus; GO:0034613 cellular protein localization; GO:0035051 cardiocyte differentiation; GO:0036211 protein modification process; GO:0042692 muscle cell differentiation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045214 sarcomere organization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051641 cellular localization; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0055003 cardiac myofibril assembly; GO:0055006 cardiac cell development; GO:0055007 cardiac muscle cell differentiation; GO:0055013 cardiac muscle cell development; GO:0060284 regulation of cell development; GO:0060537 muscle tissue development; GO:0061061 muscle structure development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071688 striated muscle myosin thick filament assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0097435 supramolecular fiber organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1901564 organonitrogen compound metabolic process; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005859 muscle myosin complex; GO:0005911 cell-cell junction; GO:0012505 endomembrane system; GO:0014704 intercalated disc; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016459 myosin complex; GO:0016460 myosin II complex; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0030054 cell junction; GO:0031430 M band; GO:0031672 A band; GO:0031674 I band; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0044291 cell-cell contact zone; GO:0048471 perinuclear region of cytoplasm; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:1990393 3M complex;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008093 cytoskeletal anchor activity; GO:0008307 structural constituent of muscle; GO:0030674 protein-macromolecule adaptor activity; GO:0042805 actinin binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding; GO:0051371 muscle alpha-actinin binding; GO:0051393 alpha-actinin binding; GO:0060090 molecular adaptor activity; GO:0097493 structural molecule activity conferring elasticity;","PF07679; PF13927","PF07679 Immunoglobulin I-set domain; PF13927 Immunoglobulin domain","Z","KOG0613","Projectin/twitchin and related proteins",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8951664 Neddylation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8951664"]
["O75150","E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5","RNF40",1.352216851,0.000555805,"up",14727.3,14992.5,15856.1,19727.7,20839.8,21061,0.824255348,0.839098022,0.887431859,1.104116995,1.166358843,1.178738932,"nucleus","K10696",null,null,"GO:0000209 protein polyubiquitination; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006513 protein monoubiquitination; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006664 glycolipid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010390 histone monoubiquitination; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016567 protein ubiquitination; GO:0016570 histone modification; GO:0016574 histone ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031440 regulation of mRNA 3'-end processing; GO:0031441 negative regulation of mRNA 3'-end processing; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032879 regulation of localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033182 regulation of histone ubiquitination; GO:0033184 positive regulation of histone ubiquitination; GO:0033523 histone H2B ubiquitination; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050684 regulation of mRNA processing; GO:0050686 negative regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1900363 regulation of mRNA polyadenylation; GO:1900364 negative regulation of mRNA polyadenylation; GO:1901135 carbohydrate derivative metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901652 response to peptide; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1902275 regulation of chromatin organization; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902914 regulation of protein polyubiquitination; GO:1902916 positive regulation of protein polyubiquitination; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903509 liposaccharide metabolic process; GO:1905269 positive regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2001141 regulation of RNA biosynthetic process; GO:2001166 regulation of histone H2B ubiquitination; GO:2001168 positive regulation of histone H2B ubiquitination; GO:2001252 positive regulation of chromosome organization;","GO:0000151 ubiquitin ligase complex; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030424 axon; GO:0031371 ubiquitin conjugating enzyme complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033503 HULC complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0098793 presynapse; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000149 SNARE binding; GO:0002039 p53 binding; GO:0003676 nucleic acid binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0017075 syntaxin-1 binding; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0019905 syntaxin binding; GO:0031624 ubiquitin conjugating enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0042393 histone binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044390 ubiquitin-like protein conjugating enzyme binding; GO:0044877 protein-containing complex binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00097","PF00097 Zinc finger"," C3HC4 type (RING finger)","O","KOG0978","E3 ubiquitin ligase involved in syntaxin degradation","WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE","http://www.wikipathways.org/instance/WP3878_r117656",null,"R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654"]
["O75151","Lysine-specific demethylase PHF2 OS=Homo sapiens OX=9606 GN=PHF2 PE=1 SV=4","PHF2",0.934758942,0.458364442,"nochange","NA",3857.49,4115.71,3338.98,3704.46,4136.09,"NA",1.007033984,1.07444474,0.87167208,0.967084066,1.07976513,"nucleus","K19414",null,null,"GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0001889 liver development; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006356 regulation of transcription by RNA polymerase I; GO:0006464 cellular protein modification process; GO:0006482 protein demethylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0008214 protein dealkylation; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016577 histone demethylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022402 cell cycle process; GO:0030901 midbrain development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033169 histone H3-K9 demethylation; GO:0035574 histone H4-K20 demethylation; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045943 positive regulation of transcription by RNA polymerase I; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0061008 hepaticobiliary system development; GO:0061187 regulation of ribosomal DNA heterochromatin assembly; GO:0061188 negative regulation of ribosomal DNA heterochromatin assembly; GO:0065007 biological regulation; GO:0070076 histone lysine demethylation; GO:0070544 histone H3-K36 demethylation; GO:0070988 demethylation; GO:0071557 histone H3-K27 demethylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902275 regulation of chromatin organization; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905268 negative regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0003682 chromatin binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005506 iron ion binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0032451 demethylase activity; GO:0032452 histone demethylase activity; GO:0032454 histone H3-methyl-lysine-9 demethylase activity; GO:0035064 methylated histone binding; GO:0035575 histone H4-methyl-lysine-20 demethylase activity; GO:0042393 histone binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051213 dioxygenase activity; GO:0051864 histone H3-methyl-lysine-36 demethylase activity; GO:0071558 histone H3-tri/di-methyl-lysine-27 demethylase activity; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding; GO:0140096 catalytic activity"," acting on a protein;","PF00628; PF02373; PF17811","PF00628 PHD-finger; PF02373 JmjC domain"," hydroxylase; PF17811 Jumonji helical domain","B","KOG1633","F-box protein JEMMA and related proteins with JmjC"," PHD"," F-box and LRR domains",null,null,"Transcription factor","R-HSA-3214842 HDMs demethylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214842;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["O75152","Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3","ZC3H11A",1.401698268,0.000297211,"up",24040.7,22531.3,22286.4,32714.9,32667.6,31136.2,0.872213868,0.817451751,0.808566603,1.186920075,1.185203997,1.129643705,"nucleus","K22415",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016973 poly(A)+ mRNA export from nucleus; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;",null,null,"S","KOG4791","Uncharacterized conserved protein",null,null,"Transcription factor","R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O75154","Rab11 family-interacting protein 3 OS=Homo sapiens OX=9606 GN=RAB11FIP3 PE=1 SV=1","RAB11FIP3",1.823928634,0.369589341,"nochange",2964.65,7493.42,"NA",9486.46,8904.9,10220.8,0.379400121,0.958967992,"NA",1.214026639,1.139601687,1.308003562,"nucleus","K12485","RAB11FIP3_4; Rab11 family-interacting protein 3/4","hsa04144 Endocytosis","GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0006810 transport; GO:0008104 protein localization; GO:0010564 regulation of cell cycle process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0032456 endocytic recycling; GO:0032465 regulation of cytokinesis; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0044057 regulation of system process; GO:0044060 regulation of endocrine process; GO:0046883 regulation of hormone secretion; GO:0046888 negative regulation of hormone secretion; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051302 regulation of cell division; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051726 regulation of cell cycle; GO:0061512 protein localization to cilium; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070163 regulation of adiponectin secretion; GO:0070164 negative regulation of adiponectin secretion; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0090087 regulation of peptide transport; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030496 midbody; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032153 cell division site; GO:0032154 cleavage furrow; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045171 intercellular bridge; GO:0055037 recycling endosome; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0051959 dynein light intermediate chain binding;",null,null,"DZ","KOG0982","Centrosomal protein Nuf",{"$nulls":3},"R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-5617833 Cilium Assembly;R-HSA-5620916 VxPx cargo-targeting to cilium;R-HSA-5620920 Cargo trafficking to the periciliary membrane","https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620916;https://reactome.org/PathwayBrowser/#/R-HSA-5620920"]
["O75164","Lysine-specific demethylase 4A OS=Homo sapiens OX=9606 GN=KDM4A PE=1 SV=2","KDM4A",1.230551166,3.575595E-3,"up",9931.8,9614.79,9301.54,11480.9,12502.7,11515.5,0.926081822,0.896522508,0.867313791,1.070526268,1.165803097,1.073752514,"nucleus","K06709",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001708 cell fate specification; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001763 morphogenesis of a branching structure; GO:0002009 morphogenesis of an epithelium; GO:0003008 system process; GO:0003012 muscle system process; GO:0003299 muscle hypertrophy in response to stress; GO:0003300 cardiac muscle hypertrophy; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006482 protein demethylation; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0008152 metabolic process; GO:0008214 protein dealkylation; GO:0008284 positive regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010941 regulation of cell death; GO:0014013 regulation of gliogenesis; GO:0014014 negative regulation of gliogenesis; GO:0014887 cardiac muscle adaptation; GO:0014888 striated muscle adaptation; GO:0014896 muscle hypertrophy; GO:0014897 striated muscle hypertrophy; GO:0014898 cardiac muscle hypertrophy in response to stress; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0016570 histone modification; GO:0016577 histone demethylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031061 negative regulation of histone methylation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033169 histone H3-K9 demethylation; GO:0035153 epithelial cell type specification"," open tracheal system; GO:0035154 terminal cell fate specification"," open tracheal system; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0042051 compound eye photoreceptor development; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043500 muscle adaptation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045165 cell fate commitment; GO:0045463 R8 cell development; GO:0045465 R8 cell differentiation; GO:0045466 R7 cell differentiation; GO:0045467 R7 cell development; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045685 regulation of glial cell differentiation; GO:0045686 negative regulation of glial cell differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048592 eye morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048710 regulation of astrocyte differentiation; GO:0048712 negative regulation of astrocyte differentiation; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051570 regulation of histone H3-K9 methylation; GO:0051573 negative regulation of histone H3-K9 methylation; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060446 branching involved in open tracheal system development; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0061138 morphogenesis of a branching epithelium; GO:0061564 axon development; GO:0065007 biological regulation; GO:0070076 histone lysine demethylation; GO:0070544 histone H3-K36 demethylation; GO:0070988 demethylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090596 sensory organ morphogenesis; GO:0097485 neuron projection guidance; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900112 regulation of histone H3-K9 trimethylation; GO:1900113 negative regulation of histone H3-K9 trimethylation; GO:1901564 organonitrogen compound metabolic process; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1905268 negative regulation of chromatin organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005721 pericentric heterochromatin; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0003824 catalytic activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008270 zinc ion binding; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0032451 demethylase activity; GO:0032452 histone demethylase activity; GO:0032454 histone H3-methyl-lysine-9 demethylase activity; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0050681 androgen receptor binding; GO:0051213 dioxygenase activity; GO:0051427 hormone receptor binding; GO:0051864 histone H3-methyl-lysine-36 demethylase activity; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding; GO:0140096 catalytic activity"," acting on a protein;","PF02373; PF13832; PF18104","PF02373 JmjC domain"," hydroxylase; PF13832 PHD-zinc-finger like domain; PF18104 Jumonji domain-containing protein 2A Tudor domain","L","KOG0958","DNA damage-responsive repressor GIS1/RPH1"," jumonji superfamily","WP2853 ENDODERM DIFFERENTIATION","http://www.wikipathways.org/instance/WP2853_r116557","Transcription factor","R-HSA-162582 Signal Transduction;R-HSA-3214842 HDMs demethylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;R-HSA-5693606 DNA Double Strand Break Response;R-HSA-73894 DNA Repair;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9024446 NR1H2 and NR1H3-mediated signaling;R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-3214842;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693565;https://reactome.org/PathwayBrowser/#/R-HSA-5693606;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9024446;https://reactome.org/PathwayBrowser/#/R-HSA-9029569"]
["O75165","DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5","DNAJC13",0.725453765,3.452068E-3,"down",9470.88,9752.65,10534.7,6930.98,6859.92,7797.32,1.10670319,1.139628932,1.231014023,0.809907598,0.801604006,0.91114225,"plasma membrane","K09533",null,null,"GO:0000003 reproduction; GO:0001667 ameboidal-type cell migration; GO:0001775 cell activation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007610 behavior; GO:0007638 mechanosensory behavior; GO:0008104 protein localization; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010631 epithelial cell migration; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016477 cell migration; GO:0016482 cytosolic transport; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0032386 regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0035418 protein localization to synapse; GO:0036230 granulocyte activation; GO:0040011 locomotion; GO:0042119 neutrophil activation; GO:0042147 retrograde transport"," endosome to Golgi; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044703 multi-organism reproductive process; GO:0045022 early endosome to late endosome transport; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0098657 import into cell; GO:0098927 vesicle-mediated transport between endosomal compartments; GO:1902954 regulation of early endosome to recycling endosome transport; GO:1903539 protein localization to postsynaptic membrane; GO:1903649 regulation of cytoplasmic transport; GO:1990778 protein localization to cell periphery; GO:2000641 regulation of early endosome to late endosome transport;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031982 vesicle; GO:0035577 azurophil granule membrane; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0055037 recycling endosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0051087 chaperone binding;","PF19432; PF14237; PF00226","PF19432 DNAJ protein RME-8 N-terminal; PF14237 GYF domain 2; PF00226 DnaJ domain","UO","KOG1789","Endocytosis protein RME-8"," contains DnaJ domain",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O75167","Phosphatase and actin regulator 2 OS=Homo sapiens OX=9606 GN=PHACTR2 PE=1 SV=2","PHACTR2",0.989623698,0.982340637,"nochange",4752.45,8160.54,6194.01,5469.08,7532.16,5907.5,0.750076153,1.287972824,0.977596648,0.863181409,1.188796009,0.932376958,"nucleus","K17594",null,null,"GO:0002576 platelet degranulation; GO:0006810 transport; GO:0006887 exocytosis; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0032940 secretion by cell; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0051179 localization; GO:0051234 establishment of localization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031091 platelet alpha granule; GO:0031092 platelet alpha granule membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle;",{"$nulls":3},"R","KOG4339","RPEL repeat-containing protein",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005"]
["O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2","PPP6R2",0.689459883,0.003819905,"down",9133.8,10192.4,10761.7,6880.73,7389.94,6473.73,1.078109785,1.203061833,1.270259264,0.812168247,0.872272945,0.764127927,"cytoplasm","K15500",null,null,"GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010921 regulation of phosphatase activity; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding;",null,null,"D","KOG2073","SAP family cell cycle dependent phosphatase-associated protein"]
["O75175","CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1","CNOT3",0.811468254,0.003094981,"down",18351.1,18837.6,18251.3,14409.2,15941.5,14637.1,1.096375705,1.125441362,1.090413212,0.860869202,0.952415566,0.874484953,"nucleus","K12580","CNOT3; CCR4-NOT transcription complex subunit 3","hsa03018 RNA degradation","GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000288 nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0001701 in utero embryonic development; GO:0001824 blastocyst development; GO:0001825 blastocyst formation; GO:0001829 trophectodermal cell differentiation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006977 DNA damage response"," signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010948 negative regulation of cell cycle process; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0017148 negative regulation of translation; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway; GO:0033146 regulation of intracellular estrogen receptor signaling pathway; GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway; GO:0033554 cellular response to stress; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035556 intracellular signal transduction; GO:0042770 signal transduction in response to DNA damage; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072331 signal transduction by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090503 RNA phosphodiester bond hydrolysis"," exonucleolytic; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:2000036 regulation of stem cell population maintenance; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;","GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030014 CCR4-NOT complex; GO:0030015 CCR4-NOT core complex; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:1990904 ribonucleoprotein complex;","GO:0000175 3'-5'-exoribonuclease activity; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004527 exonuclease activity; GO:0004532 exoribonuclease activity; GO:0004535 poly(A)-specific ribonuclease activity; GO:0004540 ribonuclease activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008408 3'-5' exonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016796 exonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; GO:0016896 exoribonuclease activity"," producing 5'-phosphomonoesters; GO:0140098 catalytic activity"," acting on RNA;",null,null,"K","KOG2150","CCR4-NOT transcriptional regulation complex"," NOT5 subunit",null,null,"Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-429914 Deadenylation-dependent mRNA decay;R-HSA-429947 Deadenylation of mRNA;R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes;R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-429914;https://reactome.org/PathwayBrowser/#/R-HSA-429947;https://reactome.org/PathwayBrowser/#/R-HSA-6791312;https://reactome.org/PathwayBrowser/#/R-HSA-6804115;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O75177","Calcium-responsive transactivator OS=Homo sapiens OX=9606 GN=SS18L1 PE=1 SV=2","SS18L1",0.823994379,0.178551918,"nochange",1637.45,1269.73,1134.85,1056.99,1110.45,1163.17,1.33258914,1.033331344,0.923563337,0.860199332,0.903706135,0.946610712,"nucleus","K15623","SS18; protein SSXT","hsa05202 Transcriptional misregulation in cancer","GO:0006355 regulation of transcription"," DNA-templated; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000785 chromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0071565 nBAF complex; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1904949 ATPase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG3227","Calcium-responsive transcription coactivator"]
["O75179","Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3","ANKRD17",1.099819538,0.005969596,"nochange",34395.8,34132.3,34928.6,37986,36819.5,38978.2,0.949983521,0.942705869,0.964699015,1.049141872,1.016924108,1.076545615,"plasma membrane","K16726",null,null,"GO:0001568 blood vessel development; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001944 vasculature development; GO:0001955 blood vessel maturation; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0006275 regulation of DNA replication; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007492 endoderm development; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019730 antimicrobial humoral response; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030239 myofibril assembly; GO:0031032 actomyosin structure organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; GO:0039533 regulation of MDA-5 signaling pathway; GO:0039535 regulation of RIG-I signaling pathway; GO:0040011 locomotion; GO:0042692 muscle cell differentiation; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043207 response to external biotic stimulus; GO:0044085 cellular component biogenesis; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045214 sarcomere organization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045787 positive regulation of cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050688 regulation of defense response to virus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051150 regulation of smooth muscle cell differentiation; GO:0051151 negative regulation of smooth muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0060255 regulation of macromolecule metabolic process; GO:0060361 flight; GO:0060548 negative regulation of cell death; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070925 organelle assembly; GO:0071695 anatomical structure maturation; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090068 positive regulation of cell cycle process; GO:0090596 sensory organ morphogenesis; GO:0097435 supramolecular fiber organization; GO:0098542 defense response to other organism; GO:1900087 positive regulation of G1/S transition of mitotic cell cycle; GO:1900245 positive regulation of MDA-5 signaling pathway; GO:1900246 positive regulation of RIG-I signaling pathway; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902808 positive regulation of cell cycle G1/S phase transition; GO:1903146 regulation of autophagy of mitochondrion; GO:1903147 negative regulation of autophagy of mitochondrion; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0031090 organelle membrane; GO:0031430 M band; GO:0031672 A band; GO:0031674 I band; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0003682 chromatin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding;","PF00013","PF00013 KH domain","T","KOG4369","RTK signaling protein MASK/UNC-44"]
["O75182","Paired amphipathic helix protein Sin3b OS=Homo sapiens OX=9606 GN=SIN3B PE=1 SV=2","SIN3B",1.130019504,0.394201756,"nochange",3156.28,3564.3,4195.09,3407.19,4212.02,4715.71,0.814503202,0.919796014,1.082576399,0.879252526,1.086945321,1.216926538,"nucleus","K23213",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001667 ameboidal-type cell migration; GO:0001708 cell fate specification; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002218 activation of innate immune response; GO:0002230 positive regulation of defense response to virus by host; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0003006 developmental process involved in reproduction; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006476 protein deacetylation; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007422 peripheral nervous system development; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007507 heart development; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0007525 somatic muscle development; GO:0007526 larval somatic muscle development; GO:0007548 sex differentiation; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010633 negative regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0014706 striated muscle tissue development; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0016570 histone modification; GO:0016575 histone deacetylation; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030539 male genitalia development; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032101 regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0035065 regulation of histone acetylation; GO:0035067 negative regulation of histone acetylation; GO:0035112 genitalia morphogenesis; GO:0035206 regulation of hemocyte proliferation; GO:0035220 wing disc development; GO:0035295 tube development; GO:0035601 protein deacylation; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040025 vulval development; GO:0042127 regulation of cell population proliferation; GO:0042752 regulation of circadian rhythm; GO:0042754 negative regulation of circadian rhythm; GO:0043170 macromolecule metabolic process; GO:0043392 negative regulation of DNA binding; GO:0043412 macromolecule modification; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045652 regulation of megakaryocyte differentiation; GO:0045786 negative regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046661 male sex differentiation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048806 genitalia development; GO:0048808 male genitalia morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050688 regulation of defense response to virus; GO:0050691 regulation of defense response to virus by host; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051674 localization of cell; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060537 muscle tissue development; GO:0060538 skeletal muscle organ development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0061061 muscle structure development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090596 sensory organ morphogenesis; GO:0090597 nematode male tail mating organ morphogenesis; GO:0090598 male anatomical structure morphogenesis; GO:0098732 macromolecule deacylation; GO:1900180 regulation of protein localization to nucleus; GO:1900181 negative regulation of protein localization to nucleus; GO:1901564 organonitrogen compound metabolic process; GO:1901674 regulation of histone H3-K27 acetylation; GO:1901675 negative regulation of histone H3-K27 acetylation; GO:1901983 regulation of protein acetylation; GO:1901984 negative regulation of protein acetylation; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903828 negative regulation of protein localization; GO:1905268 negative regulation of chromatin organization; GO:1905269 positive regulation of chromatin organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000677 regulation of transcription regulatory region DNA binding; GO:2000678 negative regulation of transcription regulatory region DNA binding; GO:2000756 regulation of peptidyl-lysine acetylation; GO:2000757 negative regulation of peptidyl-lysine acetylation; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0000118 histone deacetylase complex; GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000791 euchromatin; GO:0000803 sex chromosome; GO:0000805 X chromosome; GO:0000806 Y chromosome; GO:0001741 XY body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005737 cytoplasm; GO:0016580 Sin3 complex; GO:0017053 transcription repressor complex; GO:0030849 autosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070822 Sin3-type complex; GO:1902494 catalytic complex;","GO:0000976 transcription cis-regulatory region binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016787 hydrolase activity; GO:0019213 deacetylase activity; GO:0033558 protein deacetylase activity; GO:0043565 sequence-specific DNA binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF08295","PF08295 Sin3 family co-repressor","B","KOG4204","Histone deacetylase complex"," SIN3 component",null,null,"Transcription factor","R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-212436 Generic Transcription Pathway;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-427413;https://reactome.org/PathwayBrowser/#/R-HSA-5250941;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8936459"]
["O75190","DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2","DNAJB6",1.453083304,0.004328666,"up",19803.5,19672.8,17034.5,26593.6,25881.2,29640.1,0.857135437,0.851478478,0.73728753,1.151024666,1.120190556,1.282883333,"nucleus","K09512",null,null,"GO:0000003 reproduction; GO:0001701 in utero embryonic development; GO:0001890 placenta development; GO:0001892 embryonic placenta development; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006457 protein folding; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007155 cell adhesion; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010466 negative regulation of peptidase activity; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0010951 negative regulation of endopeptidase activity; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0022610 biological adhesion; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030198 extracellular matrix organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032781 positive regulation of ATP-dependent activity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043062 extracellular structure organization; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043462 regulation of ATP-dependent activity; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0045103 intermediate filament-based process; GO:0045104 intermediate filament cytoskeleton organization; GO:0045109 intermediate filament organization; GO:0045861 negative regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048568 embryonic organ development; GO:0048583 regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051641 cellular localization; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060669 embryonic placenta morphogenesis; GO:0060706 cell differentiation involved in embryonic placenta development; GO:0060710 chorio-allantoic fusion; GO:0060711 labyrinthine layer development; GO:0060713 labyrinthine layer morphogenesis; GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development; GO:0060717 chorion development; GO:0061077 chaperone-mediated protein folding; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090083 regulation of inclusion body assembly; GO:0090084 negative regulation of inclusion body assembly; GO:0097435 supramolecular fiber organization; GO:0098609 cell-cell adhesion; GO:1900034 regulation of cellular response to heat; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903867 extraembryonic membrane development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0031674 I band; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0001671 ATPase activator activity; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0030234 enzyme regulator activity; GO:0031072 heat shock protein binding; GO:0042802 identical protein binding; GO:0044183 protein folding chaperone; GO:0051082 unfolded protein binding; GO:0051087 chaperone binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0060590 ATPase regulator activity; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901363 heterocyclic compound binding;","PF00226","PF00226 DnaJ domain","O","KOG0714","Molecular chaperone (DnaJ superfamily)",{"$nulls":3},"R-HSA-2262752 Cellular responses to stress;R-HSA-3371453 Regulation of HSF1-mediated heat shock response;R-HSA-3371556 Cellular response to heat stress;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3371453;https://reactome.org/PathwayBrowser/#/R-HSA-3371556;https://reactome.org/PathwayBrowser/#/R-HSA-8953897"]
["O75191","Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=3","XYLB",0.996931256,0.901073737,"nochange",3550.63,4377.99,6520.29,2592.93,6710,5101.64,0.73834352,0.910390705,1.355875964,0.539192499,1.395325625,1.060871687,"nucleus","K00854","xylB; xylulokinase [EC:2.7.1.17]","hsa00040 Pentose and glucuronate interconversions; hsa01100 Metabolic pathways","GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0005997 xylulose metabolic process; GO:0005998 xylulose catabolic process; GO:0006063 uronic acid metabolic process; GO:0006064 glucuronate catabolic process; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0016052 carbohydrate catabolic process; GO:0016054 organic acid catabolic process; GO:0016310 phosphorylation; GO:0019321 pentose metabolic process; GO:0019323 pentose catabolic process; GO:0019585 glucuronate metabolic process; GO:0019637 organophosphate metabolic process; GO:0019640 glucuronate catabolic process to xylulose 5-phosphate; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046365 monosaccharide catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0046835 carbohydrate phosphorylation; GO:0051167 xylulose 5-phosphate metabolic process; GO:0071704 organic substance metabolic process; GO:0072329 monocarboxylic acid catabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901159 xylulose 5-phosphate biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043230 extracellular organelle; GO:0070062 extracellular exosome; GO:1903561 extracellular vesicle;","GO:0003824 catalytic activity; GO:0004856 xylulokinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019200 carbohydrate kinase activity;","PF00370; PF02782","PF00370 FGGY family of carbohydrate kinases"," N-terminal domain; PF02782 FGGY family of carbohydrate kinases"," C-terminal domain","G","KOG2531","Sugar (pentulose and hexulose) kinases",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-5661270 Formation of xylulose-5-phosphate;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-5661270;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["O75208","Ubiquinone biosynthesis protein COQ9"," mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1","COQ9",0.950633344,0.644161428,"nochange",9021.03,6711.81,7950.96,7472.25,7759.23,7283.13,1.171602659,0.871693636,1.032627746,0.970455477,1.007726889,0.945893592,"mitochondria","K18587",null,null,"GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006743 ubiquinone metabolic process; GO:0006744 ubiquinone biosynthetic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016310 phosphorylation; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042180 cellular ketone metabolic process; GO:0042181 ketone biosynthetic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043086 negative regulation of catalytic activity; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901661 quinone metabolic process; GO:1901663 quinone biosynthetic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008289 lipid binding; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0031625 ubiquitin protein ligase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0044389 ubiquitin-like protein ligase binding; GO:0046983 protein dimerization activity; GO:0055105 ubiquitin-protein transferase inhibitor activity; GO:0055106 ubiquitin-protein transferase regulator activity; GO:0098772 molecular function regulator;","PF08511","PF08511 COQ9","S","KOG2969","Uncharacterized conserved protein","WP5037 RIBOFLAVIN AND COQ DISORDERS","http://www.wikipathways.org/instance/WP5037_r120417",null,"R-HSA-1430728 Metabolism;R-HSA-196854 Metabolism of vitamins and cofactors;R-HSA-2142789 Ubiquinol biosynthesis;R-HSA-8978934 Metabolism of cofactors","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-196854;https://reactome.org/PathwayBrowser/#/R-HSA-2142789;https://reactome.org/PathwayBrowser/#/R-HSA-8978934","ADIPOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS"]
["O75223","Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1","GGCT",0.957224489,0.17063128,"nochange",27414.4,27337.1,26117.2,26447.2,26231.1,24731.2,1.039223342,1.036293059,0.990049167,1.002558786,0.994366881,0.937508766,"cytoplasm","K00682","GGCT; gamma-glutamylcyclotransferase [EC:4.3.2.9]","hsa00480 Glutathione metabolism; hsa01100 Metabolic pathways","GO:0001836 release of cytochrome c from mitochondria; GO:0002376 immune system process; GO:0006518 peptide metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006749 glutathione metabolic process; GO:0006750 glutathione biosynthetic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007599 hemostasis; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008637 apoptotic mitochondrial changes; GO:0009058 biosynthetic process; GO:0009611 response to wounding; GO:0009987 cellular process; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0019184 nonribosomal peptide biosynthetic process; GO:0023052 signaling; GO:0032501 multicellular organismal process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042060 wound healing; GO:0042381 hemolymph coagulation; GO:0042398 cellular modified amino acid biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0045087 innate immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0097190 apoptotic signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0003839 gamma-glutamylcyclotransferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016829 lyase activity; GO:0016840 carbon-nitrogen lyase activity; GO:0016842 amidine-lyase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity;",null,null,"S","KOG4059","Uncharacterized conserved protein","WP4518 GAMMAGLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE INCLUDING DISEASES","http://www.wikipathways.org/instance/WP4518_r119313",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-174403 Glutathione synthesis and recycling;R-HSA-211859 Biological oxidations","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-174403;https://reactome.org/PathwayBrowser/#/R-HSA-211859"]
["O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7"," mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3","NDUFS7",1.186921229,0.027194512,"nochange",41813.4,43479,48223.2,50233.1,52999.2,55240.2,0.859214468,0.89344052,0.990928055,1.032229053,1.089069041,1.135118863,"mitochondria","K03940","NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0000302 response to reactive oxygen species; GO:0002118 aggressive behavior; GO:0002121 inter-male aggressive behavior; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007610 behavior; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0010259 multicellular organism aging; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0099174 regulation of presynapse organization; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:2000331 regulation of terminal button organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0005759 mitochondrial matrix; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045202 synapse; GO:0045271 respiratory chain complex I; GO:0070013 intracellular organelle lumen; GO:0070469 respirasome; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0098590 plasma membrane region; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0002020 protease binding; GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0019899 enzyme binding; GO:0050136 NADH dehydrogenase (quinone) activity;",null,null,"C","KOG1687","NADH-ubiquinone oxidoreductase"," NUFS7/PSST/20 kDa subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O75298","Reticulon-2 OS=Homo sapiens OX=9606 GN=RTN2 PE=1 SV=1","RTN2",0.79549841,0.009796671,"down",10886.2,11032.9,10442.8,9398.15,8085.18,8260.51,1.124109253,1.139257498,1.078323759,0.970453177,0.834875866,0.852980446,"plasma membrane","K20722",null,null,"GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0010827 regulation of glucose transmembrane transport; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046324 regulation of glucose import; GO:0046907 intracellular transport; GO:0050789 regulation of biological process; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0065002 intracellular protein transmembrane transport; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0014802 terminal cisterna; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016528 sarcoplasm; GO:0016529 sarcoplasmic reticulum; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0030315 T-tubule; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042383 sarcolemma; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098827 endoplasmic reticulum subcompartment;",{"$nulls":3},"U","KOG1792","Reticulon"]
["O75306","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2"," mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2","NDUFS2",1.123298316,0.000137022,"up",125239,125712,123531,141729,138761,140165,0.945037145,0.948606341,0.9321488,1.069468532,1.047072391,1.057666792,"mitochondria","K03935","NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006120 mitochondrial electron transport"," NADH to ubiquinone; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005747 mitochondrial respiratory chain complex I; GO:0005759 mitochondrial matrix; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0030964 NADH dehydrogenase complex; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045271 respiratory chain complex I; GO:0070013 intracellular organelle lumen; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008137 NADH dehydrogenase (ubiquinone) activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016655 oxidoreductase activity"," acting on NAD(P)H"," quinone or similar compound as acceptor; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0050136 NADH dehydrogenase (quinone) activity;",null,null,"C","KOG2870","NADH:ubiquinone oxidoreductase"," NDUFS2/49 kDa subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM;WP4396 NONALCOHOLIC FATTY LIVER DISEASE;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4324_r98172;http://www.wikipathways.org/instance/WP4396_r98945;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport;R-HSA-6799198 Complex I biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-6799198","OXIDATIVE PHOSPHORYLATION;REACTIVE OXYGEN SPECIES PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"]
["O75312","Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1","ZPR1",1.093112524,0.029545394,"nochange",48467.3,49954.9,50671.6,52268.6,54061.5,56646.2,0.931854093,0.960455359,0.974234956,1.004939595,1.039410697,1.0891053,"cytoplasm","K06874",null,null,"GO:0000082 G1/S transition of mitotic cell cycle; GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0001701 in utero embryonic development; GO:0001763 morphogenesis of a branching structure; GO:0001824 blastocyst development; GO:0001832 blastocyst growth; GO:0001833 inner cell mass cell proliferation; GO:0001834 trophectodermal cell proliferation; GO:0002009 morphogenesis of an epithelium; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006355 regulation of transcription"," DNA-templated; GO:0006401 RNA catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007424 open tracheal system development; GO:0007430 terminal branching"," open tracheal system; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010941 regulation of cell death; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0021510 spinal cord development; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030575 nuclear body organization; GO:0030576 Cajal body organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031641 regulation of myelination; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033120 positive regulation of RNA splicing; GO:0033157 regulation of intracellular protein transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035148 tube formation; GO:0035149 lumen formation"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040007 growth; GO:0040008 regulation of growth; GO:0042023 DNA endoreduplication; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044786 cell cycle DNA replication; GO:0044843 cell cycle G1/S phase transition; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048589 developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060446 branching involved in open tracheal system development; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0061138 morphogenesis of a branching epithelium; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070848 response to growth factor; GO:0070849 response to epidermal growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071364 cellular response to epidermal growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0090316 positive regulation of intracellular protein transport; GO:0120036 plasma membrane bounded cell projection organization; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902742 apoptotic process involved in development; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903829 positive regulation of protein localization; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904951 positive regulation of establishment of protein localization; GO:1990261 pre-mRNA catabolic process; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000671 regulation of motor neuron apoptotic process; GO:2000672 negative regulation of motor neuron apoptotic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0015030 Cajal body; GO:0016604 nuclear body; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032797 SMN complex; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043204 perikaryon; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0070013 intracellular organelle lumen; GO:0097504 Gemini of coiled bodies; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030971 receptor tyrosine kinase binding; GO:0031369 translation initiation factor binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:1990782 protein tyrosine kinase binding;",null,null,"R","KOG2703","C4-type Zn-finger protein"]
["O75367","Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5","MACROH2A1",0.838224729,0.073069348,"nochange",337201,328788,382144,273182,278477,326912,1.050086573,1.023887426,1.19004476,0.850723308,0.867212608,1.018045325,"mitochondria","K11251","H2A; histone H2A","hsa05322 Systemic lupus erythematosus; hsa04613 Neutrophil extracellular trap formation; hsa05034 Alcoholism; hsa04217 Necroptosis","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006334 nucleosome assembly; GO:0006355 regulation of transcription"," DNA-templated; GO:0006356 regulation of transcription by RNA polymerase I; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006469 negative regulation of protein kinase activity; GO:0006996 organelle organization; GO:0007063 regulation of sister chromatid cohesion; GO:0007088 regulation of mitotic nuclear division; GO:0007346 regulation of mitotic cell cycle; GO:0007549 dosage compensation; GO:0008104 protein localization; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0016043 cellular component organization; GO:0016479 negative regulation of transcription by RNA polymerase I; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0030856 regulation of epithelial cell differentiation; GO:0030858 positive regulation of epithelial cell differentiation; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031061 negative regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031497 chromatin assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033127 regulation of histone phosphorylation; GO:0033128 negative regulation of histone phosphorylation; GO:0033365 protein localization to organelle; GO:0033673 negative regulation of kinase activity; GO:0034091 regulation of maintenance of sister chromatid cohesion; GO:0034093 positive regulation of maintenance of sister chromatid cohesion; GO:0034182 regulation of maintenance of mitotic sister chromatid cohesion; GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0034728 nucleosome organization; GO:0040029 regulation of gene expression"," epigenetic; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045604 regulation of epidermal cell differentiation; GO:0045606 positive regulation of epidermal cell differentiation; GO:0045616 regulation of keratinocyte differentiation; GO:0045618 positive regulation of keratinocyte differentiation; GO:0045682 regulation of epidermis development; GO:0045684 positive regulation of epidermis development; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045840 positive regulation of mitotic nuclear division; GO:0045859 regulation of protein kinase activity; GO:0045876 positive regulation of sister chromatid cohesion; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045931 positive regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051569 regulation of histone H3-K4 methylation; GO:0051572 negative regulation of histone H3-K4 methylation; GO:0051641 cellular localization; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051984 positive regulation of chromosome segregation; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061085 regulation of histone H3-K27 methylation; GO:0061086 negative regulation of histone H3-K27 methylation; GO:0062033 positive regulation of mitotic sister chromatid segregation; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070199 establishment of protein localization to chromosome; GO:0070727 cellular macromolecule localization; GO:0071103 DNA conformation change; GO:0071168 protein localization to chromatin; GO:0071169 establishment of protein localization to chromatin; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090068 positive regulation of cell cycle process; GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I; GO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1902882 regulation of response to oxidative stress; GO:1902883 negative regulation of response to oxidative stress; GO:1902884 positive regulation of response to oxidative stress; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903828 negative regulation of protein localization; GO:1904814 regulation of protein localization to chromosome"," telomeric region; GO:1904815 negative regulation of protein localization to chromosome"," telomeric region; GO:1905268 negative regulation of chromatin organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000785 chromatin; GO:0000786 nucleosome; GO:0000792 heterochromatin; GO:0000793 condensed chromosome; GO:0000803 sex chromosome; GO:0000805 X chromosome; GO:0001739 sex chromatin; GO:0001740 Barr body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005721 pericentric heterochromatin; GO:0005730 nucleolus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044815 DNA packaging complex; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region;","GO:0000182 rDNA binding; GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding; GO:0001046 core promoter sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0004857 enzyme inhibitor activity; GO:0004860 protein kinase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0010385 double-stranded methylated DNA binding; GO:0019207 kinase regulator activity; GO:0019210 kinase inhibitor activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0030291 protein serine/threonine kinase inhibitor activity; GO:0031490 chromatin DNA binding; GO:0031491 nucleosome binding; GO:0031492 nucleosomal DNA binding; GO:0043565 sequence-specific DNA binding; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding; GO:1990841 promoter-specific chromatin binding;","PF00125; PF01661","PF00125 Core histone H2A/H2B/H3/H4; PF01661 Macro domain","BK","KOG2633","Hismacro and SEC14 domain-containing proteins","WP4553 FBXL10 ENHANCEMENT OF MAPERK SIGNALING IN DIFFUSE LARGE BCELL LYMPHOMA;WP3969 H19 ACTION RBE2F1 SIGNALING AND CDKBETACATENIN ACTIVITY","http://www.wikipathways.org/instance/WP4553_r103606;http://www.wikipathways.org/instance/WP3969_r106437"]
["O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2","LRCH4",0.908453749,0.246278053,"nochange",17956.8,17048.5,16102.2,13897.9,15099.9,17431,1.104622587,1.048748005,0.990535831,0.854937085,0.928878787,1.072277706,"cytoplasm",{"$nulls":3},"GO:0006355 regulation of transcription"," DNA-templated; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0030011 maintenance of cell polarity; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035090 maintenance of apical/basal cell polarity; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045199 maintenance of epithelial cell apical/basal polarity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016604 nuclear body; GO:0016605 PML body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098590 plasma membrane region;",null,"PF00307","PF00307 Calponin homology (CH) domain","Z","KOG0532","Leucine-rich repeat (LRR) protein"," contains calponin homology domain"]
["O75449","Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1","KATNA1",0.703100663,0.002238329,"down",17519.4,17472.3,20093.3,13423,12747.1,12560.2,1.120461161,1.11744886,1.285076102,0.858474044,0.815246554,0.803293279,"nucleus","K07767",null,null,"GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000212 meiotic spindle organization; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001578 microtubule bundle formation; GO:0001764 neuron migration; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007019 microtubule depolymerization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007059 chromosome segregation; GO:0007143 female meiotic nuclear division; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0008104 protein localization; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0010639 negative regulation of organelle organization; GO:0010721 negative regulation of cell development; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010948 negative regulation of cell cycle process; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030239 myofibril assembly; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0031032 actomyosin structure organization; GO:0031033 myosin filament organization; GO:0031034 myosin filament assembly; GO:0031109 microtubule polymerization or depolymerization; GO:0031122 cytoplasmic microtubule organization; GO:0031175 neuron projection development; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032887 regulation of spindle elongation; GO:0032984 protein-containing complex disassembly; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0040007 growth; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040020 regulation of meiotic nuclear division; GO:0042692 muscle cell differentiation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045786 negative regulation of cell cycle; GO:0045835 negative regulation of meiotic nuclear division; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0051013 microtubule severing; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051229 meiotic spindle disassembly; GO:0051230 spindle disassembly; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051261 protein depolymerization; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051445 regulation of meiotic cell cycle; GO:0051447 negative regulation of meiotic cell cycle; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0060284 regulation of cell development; GO:0060560 developmental growth involved in morphogenesis; GO:0061061 muscle structure development; GO:0061564 axon development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070925 organelle assembly; GO:0071688 striated muscle myosin thick filament assembly; GO:0071840 cellular component organization or biogenesis; GO:0090224 regulation of spindle organization; GO:0097435 supramolecular fiber organization; GO:0098813 nuclear chromosome segregation; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1902119 regulation of meiotic spindle elongation; GO:1902120 negative regulation of meiotic spindle elongation; GO:1903008 organelle disassembly; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1904396 regulation of neuromuscular junction development; GO:1990138 neuron projection extension; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000241 regulation of reproductive process; GO:2000242 negative regulation of reproductive process;","GO:0000151 ubiquitin ligase complex; GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005811 lipid droplet; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005881 cytoplasmic microtubule; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0008352 katanin complex; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0030496 midbody; GO:0031252 cell leading edge; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031463 Cul3-RING ubiquitin ligase complex; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0097431 mitotic spindle pole; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008568 microtubule-severing ATPase activity; GO:0015631 tubulin binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017022 myosin binding; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019904 protein domain specific binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0070840 dynein complex binding; GO:0090736 MATH domain binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00004; PF17862; PF09336","PF00004 ATPase family associated with various cellular activities (AAA); PF17862 AAA+ lid domain; PF09336 Vps4 C terminal oligomerisation domain","O","KOG0738","AAA+-type ATPase",{"$nulls":5},"G2M CHECKPOINT;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O75554","WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1","WBP4",1.243784881,0.116199932,"nochange",15397.2,10826,12014.2,15440.2,14863.1,17255.8,1.076771197,0.757093821,0.84018812,1.079778313,1.039420023,1.206748527,"nucleus","K13220",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045292 mRNA cis splicing"," via spliceosome; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005686 U2 snRNP; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071005 U2-type precatalytic spliceosome; GO:0071011 precatalytic spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0070064 proline-rich region binding;","PF06220; PF00397","PF06220 U1 zinc finger; PF00397 WW domain","A","KOG0150","Spliceosomal protein FBP21",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["O75586","Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2","MED6",1.086579809,0.19029365,"nochange",5088.43,4562.69,4694.95,4878.06,5604.95,5105.14,1.01992235,0.914543289,0.941053416,0.977755893,1.123453359,1.023271694,"cytoplasm","K15128",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007406 negative regulation of neuroblast proliferation; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010721 negative regulation of cell development; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016567 protein ubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019827 stem cell population maintenance; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0042127 regulation of cell population proliferation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051123 RNA polymerase II preinitiation complex assembly; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0070897 transcription preinitiation complex assembly; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072091 regulation of stem cell proliferation; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902692 regulation of neuroblast proliferation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000647 negative regulation of stem cell proliferation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0016591 RNA polymerase II"," holoenzyme; GO:0016592 mediator complex; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0070847 core mediator complex; GO:0090575 RNA polymerase II transcription regulator complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG3169","RNA polymerase II transcriptional regulation mediator",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-1989781 PPARA activates gene expression;R-HSA-212436 Generic Transcription Pathway;R-HSA-381340 Transcriptional regulation of white adipocyte differentiation;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-556833 Metabolism of lipids;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1989781;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-381340;https://reactome.org/PathwayBrowser/#/R-HSA-400206;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["O75791","GRB2-related adapter protein 2 OS=Homo sapiens OX=9606 GN=GRAP2 PE=1 SV=1","GRAP2",0.85771424,0.028623336,"nochange",6702.3,6291.43,6515.32,5987.09,5578.68,5167.42,1.109583734,1.041563104,1.078628694,0.991178801,0.923565431,0.855480235,"cytoplasm","K07366","GRAP2; GRB2-related adaptor protein 2","hsa04660 T cell receptor signaling pathway","GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007267 cell-cell signaling; GO:0008152 metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019538 protein metabolic process; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0031294 lymphocyte costimulation; GO:0031295 T cell costimulation; GO:0032502 developmental process; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0038083 peptidyl-tyrosine autophosphorylation; GO:0038093 Fc receptor signaling pathway; GO:0038095 Fc-epsilon receptor signaling pathway; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0045785 positive regulation of cell adhesion; GO:0046777 protein autophosphorylation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004715 non-membrane spanning protein tyrosine kinase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0030674 protein-macromolecule adaptor activity; GO:0035591 signaling adaptor activity; GO:0060090 molecular adaptor activity; GO:0140096 catalytic activity"," acting on a protein;","PF00018; PF00017","PF00018 SH3 domain; PF00017 SH2 domain","T","KOG3601","Adaptor protein GRB2"," contains SH2 and SH3 domains","WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION;WP5098 TCELL ACTIVATION SARSCOV2;WP3863 TCELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5072_r115764;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP3863_r120420;http://www.wikipathways.org/instance/WP69_r120700",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1433557 Signaling by SCF-KIT;R-HSA-162582 Signal Transduction;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-202403 TCR signaling;R-HSA-202433 Generation of second messenger molecules;R-HSA-2172127 DAP12 interactions;R-HSA-2424491 DAP12 signaling;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871796 FCERI mediated MAPK activation;R-HSA-2871809 FCERI mediated Ca+2 mobilization;R-HSA-388841 Costimulation by the CD28 family;R-HSA-389356 CD28 co-stimulation;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9607240 FLT3 Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1433557;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-202403;https://reactome.org/PathwayBrowser/#/R-HSA-202433;https://reactome.org/PathwayBrowser/#/R-HSA-2172127;https://reactome.org/PathwayBrowser/#/R-HSA-2424491;https://reactome.org/PathwayBrowser/#/R-HSA-2454202;https://reactome.org/PathwayBrowser/#/R-HSA-2871796;https://reactome.org/PathwayBrowser/#/R-HSA-2871809;https://reactome.org/PathwayBrowser/#/R-HSA-388841;https://reactome.org/PathwayBrowser/#/R-HSA-389356;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9607240"]
["O75884","Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2","RBBP9",0.605905931,1.93241E-4,"down",18889,17256.9,17319,10366.7,11265.2,10762.8,1.319992173,1.205938532,1.210278175,0.724440831,0.787229384,0.752120904,"cytoplasm","K07002",null,null,"GO:0042127 regulation of cell population proliferation; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",null,"PF06821","PF06821 Serine hydrolase"]
["O75886","Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1","STAM2",1.000884277,0.934970362,"nochange",3635.19,4824.47,4850.65,4667.38,4194.73,4459.97,0.818970434,1.086902828,1.092800909,1.051512087,0.945028967,1.004784775,"nucleus","K04705","STAM; signal transducing adaptor molecule","hsa04630 JAK-STAT signaling pathway; hsa04144 Endocytosis","GO:0000003 reproduction; GO:0001505 regulation of neurotransmitter levels; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006897 endocytosis; GO:0006914 autophagy; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007617 mating behavior; GO:0007618 mating; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008333 endosome to lysosome transport; GO:0009056 catabolic process; GO:0009611 response to wounding; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010632 regulation of epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0016322 neuron remodeling; GO:0016579 protein deubiquitination; GO:0017157 regulation of exocytosis; GO:0019098 reproductive behavior; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0023061 signal release; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0034606 response to hermaphrodite contact; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0036257 multivesicular body organization; GO:0036258 multivesicular body assembly; GO:0036465 synaptic vesicle recycling; GO:0040012 regulation of locomotion; GO:0040036 regulation of fibroblast growth factor receptor signaling pathway; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042060 wound healing; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042551 neuron maturation; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway; GO:0045921 positive regulation of exocytosis; GO:0045936 negative regulation of phosphate metabolic process; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048013 ephrin receptor signaling pathway; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048488 synaptic vesicle endocytosis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060179 male mating behavior; GO:0060255 regulation of macromolecule metabolic process; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061512 protein localization to cilium; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071695 anatomical structure maturation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0097499 protein localization to non-motile cilium; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1902115 regulation of organelle assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903541 regulation of exosomal secretion; GO:1903543 positive regulation of exosomal secretion; GO:1903551 regulation of extracellular exosome assembly; GO:1904892 regulation of receptor signaling pathway via STAT; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000274 regulation of epithelial cell migration"," open tracheal system;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005829 cytosol; GO:0005929 cilium; GO:0012505 endomembrane system; GO:0030139 endocytic vesicle; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0033565 ESCRT-0 complex; GO:0036452 ESCRT complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0017124 SH3 domain binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030674 protein-macromolecule adaptor activity; GO:0032182 ubiquitin-like protein binding; GO:0035591 signaling adaptor activity; GO:0043130 ubiquitin binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0060090 molecular adaptor activity;","PF00790; PF00018","PF00790 VHS domain; PF00018 SH3 domain","T","KOG2199","Signal transducing adaptor protein STAM/STAM2","WP437 EGFEGFR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP437_r120689",null,"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-177929 Signaling by EGFR;R-HSA-182971 EGFR downregulation;R-HSA-194315 Signaling by Rho GTPases;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6806834 Signaling by MET;R-HSA-6807004 Negative regulation of MET activity;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell;R-HSA-8876384 Listeria monocytogenes entry into host cells;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT);R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-177929;https://reactome.org/PathwayBrowser/#/R-HSA-182971;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689880;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6806834;https://reactome.org/PathwayBrowser/#/R-HSA-6807004;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-8875360;https://reactome.org/PathwayBrowser/#/R-HSA-8876384;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-917729;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","IL6 JAK STAT3 SIGNALING;SPERMATOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL6_JAK_STAT3_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_SPERMATOGENESIS"]
["O76070","Gamma-synuclein OS=Homo sapiens OX=9606 GN=SNCG PE=1 SV=2","SNCG",1.181699174,0.430334962,"nochange",1818.13,840.515,1210.47,1767.71,1318.37,1486.05,1.292318846,0.597434383,0.860396778,1.256480531,0.937091626,1.056277836,"cytoplasm","K24202",null,null,"GO:0001101 response to acid chemical; GO:0001505 regulation of neurotransmitter levels; GO:0002118 aggressive behavior; GO:0002790 peptide secretion; GO:0006810 transport; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007422 peripheral nervous system development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008104 protein localization; GO:0008344 adult locomotory behavior; GO:0009306 protein secretion; GO:0009410 response to xenobiotic stimulus; GO:0009415 response to water; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010243 response to organonitrogen compound; GO:0010646 regulation of cell communication; GO:0014059 regulation of dopamine secretion; GO:0014070 response to organic cyclic compound; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030534 adult behavior; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0036276 response to antidepressant; GO:0042220 response to cocaine; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043269 regulation of ion transport; GO:0043279 response to alkaloid; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046928 regulation of neurotransmitter secretion; GO:0048583 regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050433 regulation of catecholamine secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051588 regulation of neurotransmitter transport; GO:0051599 response to hydrostatic pressure; GO:0051716 cellular response to stimulus; GO:0051952 regulation of amine transport; GO:0060341 regulation of cellular localization; GO:0060359 response to ammonium ion; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071229 cellular response to acid chemical; GO:0071462 cellular response to water stimulus; GO:0071464 cellular response to hydrostatic pressure; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072347 response to anesthetic; GO:0098916 anterograde trans-synaptic signaling; GO:0099177 regulation of trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0104004 cellular response to environmental stimulus; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903530 regulation of secretion by cell; GO:1904307 response to desipramine; GO:2001023 regulation of response to drug;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030424 axon; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0098793 presynapse; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0043014 alpha-tubulin binding; GO:0048487 beta-tubulin binding;",{"$nulls":10},"ADIPOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS"]
["O94761","ATP-dependent DNA helicase Q4 OS=Homo sapiens OX=9606 GN=RECQL4 PE=1 SV=2","RECQL4",0.648750483,0.002751378,"down",6742.54,6331.63,5925.97,4131.56,4481.07,3713.72,1.29140673,1.212704647,1.135008103,0.791322615,0.858264683,0.711293222,"cytoplasm","K10730",null,null,"GO:0000003 reproduction; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0001501 skeletal system development; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006275 regulation of DNA replication; GO:0006277 DNA amplification; GO:0006281 DNA repair; GO:0006284 base-excision repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007063 regulation of sister chromatid cohesion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007307 eggshell chorion gene amplification; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010948 negative regulation of cell cycle process; GO:0010971 positive regulation of G2/M transition of mitotic cell cycle; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032200 telomere organization; GO:0032392 DNA geometric change; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032508 DNA duplex unwinding; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036292 DNA rewinding; GO:0042127 regulation of cell population proliferation; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043473 pigmentation; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045740 positive regulation of DNA replication; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045875 negative regulation of sister chromatid cohesion; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048705 skeletal system morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0061820 telomeric D-loop disassembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0090657 telomeric loop disassembly; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902751 positive regulation of cell cycle G2/M phase transition; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000781 chromosome"," telomeric region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0098687 chromosomal region;","GO:0000166 nucleotide binding; GO:0000217 DNA secondary structure binding; GO:0000405 bubble DNA binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003684 damaged DNA binding; GO:0003697 single-stranded DNA binding; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0009378 four-way junction helicase activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032356 oxidized DNA binding; GO:0032357 oxidized purine DNA binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0036310 ATP-dependent DNA/DNA annealing activity; GO:0043138 3'-5' DNA helicase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0061821 telomeric D-loop binding; GO:0062037 D-loop DNA binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00270; PF00271","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain","L","KOG0351","ATP-dependent DNA helicase"]
["O94855","Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2","SEC24D",0.711187113,0.000394999,"down",12831,12364.8,12697.8,9358.39,9105.82,8485.23,1.187266976,1.144128961,1.174941829,0.865942436,0.842571847,0.785147951,"cytoplasm","K14007","SEC24; protein transport protein SEC24","hsa05130 Pathogenic Escherichia coli infection; hsa04141 Protein processing in endoplasmic reticulum","GO:0000902 cell morphogenesis; GO:0002376 immune system process; GO:0002474 antigen processing and presentation of peptide antigen via MHC class I; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0002790 peptide secretion; GO:0003330 regulation of extracellular matrix constituent secretion; GO:0003331 positive regulation of extracellular matrix constituent secretion; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007030 Golgi organization; GO:0007163 establishment or maintenance of cell polarity; GO:0007275 multicellular organism development; GO:0007424 open tracheal system development; GO:0007517 muscle organ development; GO:0008104 protein localization; GO:0008360 regulation of cell shape; GO:0009306 protein secretion; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016203 muscle attachment; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030011 maintenance of cell polarity; GO:0030155 regulation of cell adhesion; GO:0030198 extracellular matrix organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0034394 protein localization to cell surface; GO:0034613 cellular protein localization; GO:0035148 tube formation; GO:0035149 lumen formation"," open tracheal system; GO:0035150 regulation of tube size; GO:0035151 regulation of tube size"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035158 regulation of tube diameter"," open tracheal system; GO:0035159 regulation of tube length"," open tracheal system; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035296 regulation of tube diameter; GO:0035459 vesicle cargo loading; GO:0040003 chitin-based cuticle development; GO:0042335 cuticle development; GO:0042886 amide transport; GO:0043062 extracellular structure organization; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045184 establishment of protein localization; GO:0045785 positive regulation of cell adhesion; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048070 regulation of developmental pigmentation; GO:0048079 regulation of cuticle pigmentation; GO:0048081 positive regulation of cuticle pigmentation; GO:0048087 positive regulation of developmental pigmentation; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051668 localization within membrane; GO:0060538 skeletal muscle organ development; GO:0060541 respiratory system development; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071711 basement membrane organization; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0090066 regulation of anatomical structure size; GO:0090110 COPII-coated vesicle cargo loading; GO:0090114 COPII-coated vesicle budding; GO:1903053 regulation of extracellular matrix organization; GO:1903055 positive regulation of extracellular matrix organization; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005798 Golgi-associated vesicle; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0012507 ER to Golgi transport vesicle membrane; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030120 vesicle coat; GO:0030127 COPII vesicle coat; GO:0030133 transport vesicle; GO:0030134 COPII-coated ER to Golgi transport vesicle; GO:0030135 coated vesicle; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0030662 coated vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048475 coated membrane; GO:0070971 endoplasmic reticulum exit site; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000149 SNARE binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding;","PF04810; PF04811; PF08033; PF04815; PF00626","PF04810 Sec23/Sec24 zinc finger; PF04811 Sec23/Sec24 trunk domain; PF08033 Sec23/Sec24 beta-sandwich domain; PF04815 Sec23/Sec24 helical domain; PF00626 Gelsolin repeat","U","KOG1984","Vesicle coat complex COPII"," subunit SFB3","WP1982 STEROL REGULATORY ELEMENTBINDING PROTEINS SREBP SIGNALING","http://www.wikipathways.org/instance/WP1982_r116442",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-1643685 Disease;R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF);R-HSA-168256 Immune System;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-2132295 MHC class II antigen presentation;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-556833 Metabolism of lipids;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5694530 Cargo concentration in the ER;R-HSA-597592 Post-translational protein modification;R-HSA-8957322 Metabolism of steroids;R-HSA-948021 Transport to the Golgi and subsequent modification;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983170 Antigen Presentation: Folding"," assembly and peptide loading of class I MHC","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1655829;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-2132295;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5694530;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8957322;https://reactome.org/PathwayBrowser/#/R-HSA-948021;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9705671;https://reactome.org/PathwayBrowser/#/R-HSA-9705683;https://reactome.org/PathwayBrowser/#/R-HSA-983169;https://reactome.org/PathwayBrowser/#/R-HSA-983170","ANDROGEN RESPONSE;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["O94886","CSC1-like protein 1 OS=Homo sapiens OX=9606 GN=TMEM63A PE=1 SV=3","TMEM63A",0.519210417,0.013863504,"nochange",11207.7,9510.09,13326.5,4617.36,5975.8,7082.99,1.300186155,1.103249315,1.545984528,0.535652056,0.693242362,0.821685585,"plasma membrane","K21989",null,null,"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0032940 secretion by cell; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0035579 specific granule membrane; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0070820 tertiary granule; GO:0070821 tertiary granule membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;",null,"PF14703","PF14703 Cytosolic domain of 10TM putative phosphate transporter","R","KOG1134","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O94992","Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1","HEXIM1",1.374508467,0.103529082,"nochange",9792.22,10847.4,7326.45,15386.2,11169.9,11883.5,0.884763605,0.980103054,0.661972088,1.390200566,1.009242132,1.073718554,"nucleus","K15189",null,null,"GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002218 activation of innate immune response; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006469 negative regulation of protein kinase activity; GO:0007275 multicellular organism development; GO:0007507 heart development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033673 negative regulation of kinase activity; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045786 negative regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901798 positive regulation of signal transduction by p53 class mediator; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904030 negative regulation of cyclin-dependent protein kinase activity; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0004857 enzyme inhibitor activity; GO:0004860 protein kinase inhibitor activity; GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity; GO:0005488 binding; GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity; GO:0017069 snRNA binding; GO:0019207 kinase regulator activity; GO:0019210 kinase inhibitor activity; GO:0019887 protein kinase regulator activity; GO:0030234 enzyme regulator activity; GO:0030291 protein serine/threonine kinase inhibitor activity; GO:0097159 organic cyclic compound binding; GO:0097322 7SK snRNA binding; GO:0098772 molecular function regulator; GO:1901363 heterocyclic compound binding;",{"$nulls":5},"WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR","http://www.wikipathways.org/instance/WP3414_r106735","Transcription factor",null,null,"P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["O95140","Mitofusin-2 OS=Homo sapiens OX=9606 GN=MFN2 PE=1 SV=3","MFN2",1.464339324,0.002665297,"up",29070.1,29346.1,34118.5,43771.3,47464,44266.9,0.764878842,0.772140825,0.897709976,1.151689924,1.248850515,1.164729919,"mitochondria","K06030","MFN2; mitofusin 2 [EC:3.6.5.-]","hsa04621 NOD-like receptor signaling pathway; hsa04137 Mitophagy - animal; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05012 Parkinson disease","GO:0000003 reproduction; GO:0000045 autophagosome assembly; GO:0000278 mitotic cell cycle; GO:0001101 response to acid chemical; GO:0001654 eye development; GO:0001666 response to hypoxia; GO:0001678 cellular glucose homeostasis; GO:0001701 in utero embryonic development; GO:0001824 blastocyst development; GO:0001825 blastocyst formation; GO:0002165 instar larval or pupal development; GO:0003006 developmental process involved in reproduction; GO:0006066 alcohol metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006629 lipid metabolic process; GO:0006694 steroid biosynthetic process; GO:0006697 ecdysone biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006886 intracellular protein transport; GO:0006914 autophagy; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007029 endoplasmic reticulum organization; GO:0007033 vacuole organization; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007548 sex differentiation; GO:0007584 response to nutrient; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008053 mitochondrial fusion; GO:0008088 axo-dendritic transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008205 ecdysone metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008344 adult locomotory behavior; GO:0008361 regulation of cell size; GO:0008406 gonad development; GO:0008584 male gonad development; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009116 nucleoside metabolic process; GO:0009117 nucleotide metabolic process; GO:0009119 ribonucleoside metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009314 response to radiation; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010042 response to manganese ion; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010256 endomembrane system organization; GO:0010310 regulation of hydrogen peroxide metabolic process; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010635 regulation of mitochondrial fusion; GO:0010636 positive regulation of mitochondrial fusion; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010656 negative regulation of muscle cell apoptotic process; GO:0010660 regulation of muscle cell apoptotic process; GO:0010661 positive regulation of muscle cell apoptotic process; GO:0010662 regulation of striated muscle cell apoptotic process; GO:0010664 negative regulation of striated muscle cell apoptotic process; GO:0010665 regulation of cardiac muscle cell apoptotic process; GO:0010667 negative regulation of cardiac muscle cell apoptotic process; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010726 positive regulation of hydrogen peroxide metabolic process; GO:0010728 regulation of hydrogen peroxide biosynthetic process; GO:0010729 positive regulation of hydrogen peroxide biosynthetic process; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010817 regulation of hormone levels; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010918 positive regulation of mitochondrial membrane potential; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010970 transport along microtubule; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014013 regulation of gliogenesis; GO:0014014 negative regulation of gliogenesis; GO:0014070 response to organic cyclic compound; GO:0014823 response to activity; GO:0014850 response to muscle activity; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016125 sterol metabolic process; GO:0016126 sterol biosynthetic process; GO:0016236 macroautophagy; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019725 cellular homeostasis; GO:0019896 axonal transport of mitochondrion; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030003 cellular cation homeostasis; GO:0030154 cell differentiation; GO:0030534 adult behavior; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0031670 cellular response to nutrient; GO:0031960 response to corticosteroid; GO:0032368 regulation of lipid transport; GO:0032370 positive regulation of lipid transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0033574 response to testosterone; GO:0033993 response to lipid; GO:0034284 response to monosaccharide; GO:0034389 lipid droplet organization; GO:0034391 regulation of smooth muscle cell apoptotic process; GO:0034393 positive regulation of smooth muscle cell apoptotic process; GO:0034497 protein localization to phagophore assembly site; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034643 establishment of mitochondrion localization",{"$cut":{"chars":16608,"head":" microtubule-mediated; GO:0034754 cellular hormone metabolic process; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034976 response to endoplasmic reticulum stress; GO:0035561 regulation of chromatin binding; GO:0035563 positive regulation of chromatin binding; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042180 cellular ketone metabolic process; GO:0042181 ketone biosynthetic process; GO:0042221 response to chemical; GO:0042278 purine nucleoside metabolic process; GO:0042391 regulation of membrane potential; GO:0042445 hormone metabolic process; GO:0042446 hormone biosynthetic process; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043010 camera-type eye development; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043200 response to amino acid; GO:0043457 regulation of cellular respiration; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0044057 regulation of system process; GO:0044060 regulation of endocrine process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045137 development of primary sexual characteristics; GO:0045184 establishment of protein localization; GO:0045455 ecdysteroid metabolic process; GO:0045456 ecdysteroid biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045786 negative regulation of cell cycle; GO:0045792 negative regulation of cell size; GO:0045838 positive regulation of membrane potential; GO:0045930 negative regulation of mitotic cell cycle; GO:0046039 GTP metabolic process; GO:0046128 purine ribonucleoside metabolic process; GO:0046165 alcohol biosynthetic process; GO:0046324 regulation of glucose import; GO:0046326 positive regulation of glucose import; GO:0046483 heterocycle metabolic process; GO:0046546 development of primary male sexual characteristics; GO:0046578 regulation of Ras protein signal transduction; GO:0046580 negative regulation of Ras protein signal transduction; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046628 positive regulation of insulin receptor signaling pathway; GO:0046661 male sex differentiation; GO:0046686 response to cadmium ion; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0046907 intracellular transport; GO:0047497 mitochondrion transport along microtubule; GO:0048232 male gamete generation; GO:0048284 organelle fusion; GO:0048311 mitochondrion distribution; GO:0048312 intracellular distribution of mitochondria; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:004"}},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031306 intrinsic component of mitochondrial outer membrane; GO:0031307 integral component of mitochondrial outer membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0098573 intrinsic component of mitochondrial membrane; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098799 outer mitochondrial membrane protein complex;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005525 GTP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0031625 ubiquitin protein ligase binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043394 proteoglycan binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00350","PF00350 Dynamin family","O","KOG0448","Mitofusin 1 GTPase"," involved in mitochondrila biogenesis","WP4856 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY","http://www.wikipathways.org/instance/WP4856_r113654",null,"R-HSA-109582 Hemostasis;R-HSA-162582 Signal Transduction;R-HSA-1632852 Macroautophagy;R-HSA-5205647 Mitophagy;R-HSA-5205685 PINK1-PRKN Mediated Mitophagy;R-HSA-9013419 RHOT2 GTPase cycle;R-HSA-9612973 Autophagy;R-HSA-9663891 Selective autophagy;R-HSA-9715370 Miro GTPase Cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-5205647;https://reactome.org/PathwayBrowser/#/R-HSA-5205685;https://reactome.org/PathwayBrowser/#/R-HSA-9013419;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9663891;https://reactome.org/PathwayBrowser/#/R-HSA-9715370;https://reactome.org/PathwayBrowser/#/R-HSA-9716542;https://reactome.org/PathwayBrowser/#/R-HSA-983231","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["O95232","Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2","LUC7L3",0.946291055,0.355175082,"nochange",26467.5,28910.1,26664.6,23839.9,27971.9,25824,0.994532747,1.086314959,1.001938902,0.895799046,1.051061511,0.970352835,"nucleus",{"$nulls":3},"GO:0000245 spliceosomal complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006376 mRNA splice site selection; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005685 U1 snRNP; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071004 U2-type prespliceosome; GO:0071010 prespliceosome; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG0796","Spliceosome subunit",{"$nulls":5},"E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["O95376","E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1","ARIH2",1.096621019,0.102324661,"nochange",9238.52,9092.79,9216.94,10833.6,10026.9,9349.49,0.959709299,0.944570679,0.957467541,1.125408253,1.041607223,0.971237004,"nucleus","K11969",null,null,"GO:0000209 protein polyubiquitination; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0016049 cell growth; GO:0016567 protein ubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0036211 protein modification process; GO:0040007 growth; GO:0042176 regulation of protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070534 protein K63-linked ubiquitination; GO:0070647 protein modification by small protein conjugation or removal; GO:0070936 protein K48-linked ubiquitination; GO:0071425 hematopoietic stem cell proliferation; GO:0071704 organic substance metabolic process; GO:0072089 stem cell proliferation; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0031624 ubiquitin conjugating enzyme binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044390 ubiquitin-like protein conjugating enzyme binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF01485; PF19422","PF01485 IBR domain"," a half RING-finger domain; PF19422 Ariadne domain","O","KOG1812","Predicted E3 ubiquitin ligase","WP5072 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION","http://www.wikipathways.org/instance/WP5072_r115764",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["O95394","Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1","PGM3",0.737956772,0.000911117,"down",22852.1,23506.4,22078.3,17462.9,15874.1,17166.4,1.152786022,1.185792524,1.11375128,0.880925036,0.800777197,0.86596794,"cytoplasm","K01836","PGM3; phosphoacetylglucosamine mutase [EC:5.4.2.3]","hsa01250 Biosynthesis of nucleotide sugars; hsa00520 Amino sugar and nucleotide sugar metabolism; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0001704 formation of primary germ layer; GO:0001707 mesoderm formation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006040 amino sugar metabolic process; GO:0006041 glucosamine metabolic process; GO:0006047 UDP-N-acetylglucosamine metabolic process; GO:0006048 UDP-N-acetylglucosamine biosynthetic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006487 protein N-linked glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007369 gastrulation; GO:0007498 mesoderm development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009226 nucleotide-sugar biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0018130 heterocycle biosynthetic process; GO:0019255 glucose 1-phosphate metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030097 hemopoiesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0040036 regulation of fibroblast growth factor receptor signaling pathway; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway; GO:0046349 amino sugar biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048232 male gamete generation; GO:0048332 mesoderm morphogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060438 trachea development; GO:0060541 respiratory system development; GO:0065007 biological regulation; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0090287 regulation of cellular response to growth factor stimulus; GO:1901071 glucosamine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004610 phosphoacetylglucosamine mutase activity; GO:0004614 phosphoglucomutase activity; GO:0016853 isomerase activity; GO:0016866 intramolecular transferase activity; GO:0016868 intramolecular transferase activity"," phosphotransferases;","PF02878","PF02878 Phosphoglucomutase/phosphomannomutase"," alpha/beta/alpha domain I","G","KOG2537","Phosphoglucomutase/phosphomannomutase","WP698 GLUCURONIDATION","http://www.wikipathways.org/instance/WP698_r106827","Transcription factor","R-HSA-392499 Metabolism of proteins;R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide"," LLO) and transfer to a nascent protein;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine;R-HSA-446219 Synthesis of substrates in N-glycan biosythesis;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446193;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-446210;https://reactome.org/PathwayBrowser/#/R-HSA-446219;https://reactome.org/PathwayBrowser/#/R-HSA-597592","ANDROGEN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE"]
["O95619","YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1","YEATS4",0.757330051,0.002513914,"down",10899.6,10430.1,11371.3,7727.44,8591.28,8446.73,1.138013571,1.088993665,1.187263177,0.806812323,0.897004774,0.88191249,"cytoplasm","K11341",null,null,"GO:0000278 mitotic cell cycle; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007049 cell cycle; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016246 RNA interference; GO:0016441 posttranscriptional gene silencing; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0031047 gene silencing by RNA; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034728 nucleosome organization; GO:0035194 post-transcriptional gene silencing by RNA; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043486 histone exchange; GO:0043543 protein acylation; GO:0043933 protein-containing complex organization; GO:0043967 histone H4 acetylation; GO:0043968 histone H2A acetylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051641 cellular localization; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070828 heterochromatin organization; GO:0071168 protein localization to chromatin; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097355 protein localization to heterochromatin; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000123 histone acetyltransferase complex; GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005669 transcription factor TFIID complex; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016363 nuclear matrix; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031090 organelle membrane; GO:0031248 protein acetyltransferase complex; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0035267 NuA4 histone acetyltransferase complex; GO:0043189 H4/H2A histone acetyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1902562 H4 histone acetyltransferase complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF03366","PF03366 YEATS family","K","KOG3149","Transcription initiation factor IIF"," auxiliary subunit",null,null,"Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-3214847 HATs acetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3214847;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8864260;https://reactome.org/PathwayBrowser/#/R-HSA-8866907"]
["O95644","Nuclear factor of activated T-cells"," cytoplasmic 1 OS=Homo sapiens OX=9606 GN=NFATC1 PE=1 SV=3","NFATC1",1.128379157,0.101216578,"nochange",5311.63,5669.92,5857.71,5794.32,6359.17,6847.58,0.889215585,0.949196617,0.980634386,0.970022318,1.06458339,1.146347704,"nucleus","K04446","NFATC1; nuclear factor of activated T-cells"," cytoplasmic 1","hsa04380 Osteoclast differentiation; hsa04921 Oxytocin signaling pathway; hsa05161 Hepatitis B; hsa05170 Human immunodeficiency virus 1 infection; hsa04650 Natural killer cell mediated cytotoxicity; hsa05166 Human T-cell leukemia virus 1 infection; hsa04310 Wnt signaling pathway; hsa05321 Inflammatory bowel disease; hsa04660 T cell receptor signaling pathway; hsa04625 C-type lectin receptor signaling pathway; hsa05135 Yersinia infection; hsa04010 MAPK signaling pathway; hsa04662 B cell receptor signaling pathway; hsa04658 Th1 and Th2 cell differentiation; hsa05163 Human cytomegalovirus infection; hsa04659 Th17 cell differentiation; hsa04024 cAMP signaling pathway; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04218 Cellular senescence; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa05417 Lipid and atherosclerosis; hsa04933 AGE-RAGE signaling pathway in diabetic complications; hsa04022 cGMP-PKG signaling pathway","GO:0000082 G1/S transition of mitotic cell cycle; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000278 mitotic cell cycle; GO:0001763 morphogenesis of a branching structure; GO:0001775 cell activation; GO:0001837 epithelial to mesenchymal transition; GO:0001923 B-1 B cell differentiation; GO:0001944 vasculature development; GO:0001945 lymph vessel development; GO:0001946 lymphangiogenesis; GO:0002009 morphogenesis of an epithelium; GO:0002335 mature B cell differentiation; GO:0002337 B-1a B cell differentiation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0003007 heart morphogenesis; GO:0003170 heart valve development; GO:0003176 aortic valve development; GO:0003177 pulmonary valve development; GO:0003179 heart valve morphogenesis; GO:0003180 aortic valve morphogenesis; GO:0003184 pulmonary valve morphogenesis; GO:0003205 cardiac chamber development; GO:0003206 cardiac chamber morphogenesis; GO:0003231 cardiac ventricle development; GO:0003279 cardiac septum development; GO:0003281 ventricular septum development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007223 Wnt signaling pathway"," calcium modulating pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007507 heart development; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0014733 regulation of skeletal muscle adaptation; GO:0014883 transition between fast and slow fiber; GO:0016055 Wnt signaling pathway; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019722 calcium-mediated signaling; GO:0019932 second-messenger-mediated signaling; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030001 metal ion transport; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030099 myeloid cell differentiation; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030183 B cell differentiation; GO:0030278 regulation of ossification; GO:0030279 negative regulation of ossification; GO:0030316 osteoclast differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0033173 calcineurin-NFAT signaling cascade; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0035567 non-canonical Wnt signaling pathway; GO:0036303 lymph vessel morphogenesis; GO:0038093 Fc receptor signaling pathway; GO:0038095 Fc-epsilon receptor signaling pathway; GO:0042113 B cell activation; GO:0042127 regulation of cell population proliferation; GO:0042634 regulation of hair cycle; GO:0043170 macromolecule metabolic process; GO:0043502 regulation of muscle adaptation; GO:0044057 regulation of system process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045667 regulation of osteoblast differentiation; GO:0045668 negative regulation of osteoblast differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046649 lymphocyte activation; GO:0048016 inositol phosphate-mediated signaling; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048762 mesenchymal cell differentiation; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051150 regulation of smooth muscle cell differentiation; GO:0051151 negative regulation of smooth muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060411 cardiac septum morphogenesis; GO:0060412 ventricular septum morphogenesis; GO:0060429 epithelium development; GO:0060485 mesenchyme development; GO:0060562 epithelial tube morphogenesis; GO:0060854 branching involved in lymph vessel morphogenesis; GO:0061138 morphogenesis of a branching epithelium; GO:0061383 trabecula morphogenesis; GO:0061384 heart trabecula morphogenesis; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072091 regulation of stem cell proliferation; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090257 regulation of muscle system process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0097720 calcineurin-mediated signaling; GO:0198738 cell-cell signaling by wnt; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905063 regulation of vascular associated smooth muscle cell differentiation; GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:1905314 semi-lunar valve development; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000647 negative regulation of stem cell proliferation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001221 transcription coregulator binding; GO:0001223 transcription coactivator binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005527 macrolide binding; GO:0005528 FK506 binding; GO:0008134 transcription factor binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0043565 sequence-specific DNA binding; GO:0048273 mitogen-activated protein kinase p38 binding; GO:0051019 mitogen-activated protein kinase binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00554; PF16179","PF00554 Rel homology DNA-binding domain; PF16179 Rel homology dimerisation domain",{"$nulls":3},"WP4585 CANCER IMMUNOTHERAPY BY PD1 BLOCKADE;WP2858 ECTODERM DIFFERENTIATION;WP2840 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION PART 3 OF 3;WP1591 HEART DEVELOPMENT;WP4666 HEPATITIS B INFECTION;WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR;WP382 MAPK SIGNALING PATHWAY;WP2018 RANKLRANK SIGNALING PATHWAY;WP5098 TCELL ACTIVATION SARSCOV2;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY;WP4482 VITAMIN D IN INFLAMMATORY DISEASES;WP428 WNT SIGNALING","http://www.wikipathways.org/instance/WP4585_r108119;http://www.wikipathways.org/instance/WP2858_r116763;http://www.wikipathways.org/instance/WP2840_r117745;http://www.wikipathways.org/instance/WP1591_r118366;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP3414_r106735;http://www.wikipathways.org/instance/WP382_r119087;http://www.wikipathways.org/instance/WP2018_r120672;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP69_r120700;http://www.wikipathways.org/instance/WP3888_r116782;http://www.wikipathways.org/instance/WP4482_r112969;http://www.wikipathways.org/instance/WP428_r116549","Transcription factor","R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1280218 Adaptive Immune System;R-HSA-162582 Signal Transduction;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-195721 Signaling by WNT;R-HSA-2025928 Calcineurin activates NFAT;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871809 FCERI mediated Ca+2 mobilization;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-4086398 Ca2+ pathway;R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-983705 Signaling by the B Cell Receptor (BCR)","https://reactome.org/PathwayBrowser/#/R-HSA-1168372;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-2025928;https://reactome.org/PathwayBrowser/#/R-HSA-2454202;https://reactome.org/PathwayBrowser/#/R-HSA-2871809;https://reactome.org/PathwayBrowser/#/R-HSA-3858494;https://reactome.org/PathwayBrowser/#/R-HSA-4086398;https://reactome.org/PathwayBrowser/#/R-HSA-5607763;https://reactome.org/PathwayBrowser/#/R-HSA-5607764;https://reactome.org/PathwayBrowser/#/R-HSA-5621481;https://reactome.org/PathwayBrowser/#/R-HSA-983705"]
["O95793","Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2","STAU1",1.155924046,5.72377E-4,"up",72299.8,74307.6,72508.9,85145.9,85647.7,82488.2,0.918290738,0.943792111,0.920946549,1.081451005,1.087824443,1.047695154,"nucleus","K17597",null,null,"GO:0000003 reproduction; GO:0000578 embryonic axis specification; GO:0001709 cell fate determination; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006403 RNA localization; GO:0006417 regulation of translation; GO:0007017 microtubule-based process; GO:0007028 cytoplasm organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007316 pole plasm RNA localization; GO:0007317 regulation of pole plasm oskar mRNA localization; GO:0007318 pole plasm protein localization; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007400 neuroblast fate determination; GO:0007405 neuroblast proliferation; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008104 protein localization; GO:0008283 cell population proliferation; GO:0008298 intracellular mRNA localization; GO:0008356 asymmetric cell division; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010603 regulation of cytoplasmic mRNA processing body assembly; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0014016 neuroblast differentiation; GO:0014017 neuroblast fate commitment; GO:0016043 cellular component organization; GO:0017145 stem cell division; GO:0019094 pole plasm mRNA localization; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0035282 segmentation; GO:0035418 protein localization to synapse; GO:0036445 neuronal stem cell division; GO:0040008 regulation of growth; GO:0042592 homeostatic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0045165 cell fate commitment; GO:0045167 asymmetric protein localization involved in cell fate determination; GO:0045450 bicoid mRNA localization; GO:0045451 pole plasm oskar mRNA localization; GO:0045595 regulation of cell differentiation; GO:0045727 positive regulation of translation; GO:0045887 positive regulation of synaptic assembly at neuromuscular junction; GO:0045927 positive regulation of growth; GO:0045995 regulation of embryonic development; GO:0046011 regulation of oskar mRNA translation; GO:0046012 positive regulation of oskar mRNA translation; GO:0046719 regulation by virus of viral protein levels in host cell; GO:0046726 positive regulation by virus of viral protein levels in host cell; GO:0048103 somatic stem cell division; GO:0048167 regulation of synaptic plasticity; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048863 stem cell differentiation; GO:0048865 stem cell fate commitment; GO:0048867 stem cell fate determination; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050877 nervous system process; GO:0050890 cognition; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051301 cell division; GO:0051641 cellular localization; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0055057 neuroblast division; GO:0055059 asymmetric neuroblast division; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060149 negative regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060281 regulation of oocyte development; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0060966 regulation of gene silencing by RNA; GO:0060967 negative regulation of gene silencing by RNA; GO:0061351 neural precursor cell proliferation; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0072089 stem cell proliferation; GO:0080090 regulation of primary metabolic process; GO:0098722 asymmetric stem cell division; GO:0099177 regulation of trans-synaptic signaling; GO:1900271 regulation of long-term synaptic potentiation; GO:1900273 positive regulation of long-term synaptic potentiation; GO:1900368 regulation of RNA interference; GO:1900369 negative regulation of RNA interference; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1902875 regulation of embryonic pattern specification; GO:1903429 regulation of cell maturation; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:1904396 regulation of neuromuscular junction development; GO:1904398 positive regulation of neuromuscular junction development; GO:1904580 regulation of intracellular mRNA localization; GO:1905879 regulation of oogenesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000241 regulation of reproductive process;","GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005791 rough endoplasmic reticulum; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005875 microtubule associated complex; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0009925 basal plasma membrane; GO:0010494 cytoplasmic stress granule; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0045177 apical part of cell; GO:0045178 basal part of cell; GO:0045179 apical cortex; GO:0045180 basal cortex; GO:0045202 synapse; GO:0045495 pole plasm; GO:0060293 germ plasm; GO:0061174 type I terminal bouton; GO:0070013 intracellular organelle lumen; GO:0071212 subsynaptic reticulum; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003725 double-stranded RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008157 protein phosphatase 1 binding; GO:0015631 tubulin binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00035; PF16482","PF00035 Double-stranded RNA binding motif; PF16482 Staufen C-terminal domain","UK","KOG3732","Staufen and related double-stranded-RNA-binding proteins",{"$nulls":5},"MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["O95900","Pseudouridylate synthase TRUB2"," mitochondrial OS=Homo sapiens OX=9606 GN=TRUB2 PE=1 SV=1","TRUB2",0.405042622,0.000847746,"down",7047.88,8777.37,9051.49,3175.56,3785.97,3114.61,1.209836786,1.506720476,1.553775826,0.545115596,0.649898377,0.534652938,"mitochondria","K23497",null,null,"GO:0006417 regulation of translation; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0045727 positive regulation of translation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070129 regulation of mitochondrial translation; GO:0070131 positive regulation of mitochondrial translation; GO:0080090 regulation of primary metabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;",{"$nulls":3},"J","KOG2559","Predicted pseudouridine synthase"]
["O95997","Securin OS=Homo sapiens OX=9606 GN=PTTG1 PE=1 SV=1","PTTG1",0.782456577,0.044751931,"nochange",4355.17,4328.67,3603.5,2852.88,3449.7,3311.73,1.193107369,1.185847642,0.987185897,0.781552075,0.945052085,0.907254933,"cytoplasm","K06635","PTTG; securin","hsa04110 Cell cycle; hsa05166 Human T-cell leukemia virus 1 infection; hsa04114 Oocyte meiosis","GO:0000003 reproduction; GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0001558 regulation of cell growth; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007062 sister chromatid cohesion; GO:0007064 mitotic sister chromatid cohesion; GO:0007088 regulation of mitotic nuclear division; GO:0007127 meiosis I; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010466 negative regulation of peptidase activity; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010948 negative regulation of cell cycle process; GO:0010951 negative regulation of endopeptidase activity; GO:0010965 regulation of mitotic sister chromatid separation; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0032774 RNA biosynthetic process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033046 negative regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033048 negative regulation of mitotic sister chromatid segregation; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0040008 regulation of growth; GO:0042127 regulation of cell population proliferation; GO:0043086 negative regulation of catalytic activity; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045132 meiotic chromosome segregation; GO:0045143 homologous chromosome segregation; GO:0045786 negative regulation of cell cycle; GO:0045839 negative regulation of mitotic nuclear division; GO:0045861 negative regulation of proteolysis; GO:0045930 negative regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051985 negative regulation of chromosome segregation; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0061982 meiosis I cell cycle process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1905818 regulation of chromosome separation; GO:1905819 negative regulation of chromosome separation; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000816 negative regulation of mitotic sister chromatid separation; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0004869 cysteine-type endopeptidase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0031072 heat shock protein binding; GO:0043021 ribonucleoprotein complex binding; GO:0043022 ribosome binding; GO:0044877 protein-containing complex binding; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0098772 molecular function regulator; GO:0140110 transcription regulator activity;",{"$nulls":5},"WP179 CELL CYCLE;WP5117 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME;WP4240 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASEANAPHASE TRANSITION","http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP5117_r119395;http://www.wikipathways.org/instance/WP4240_r106495","Transcription factor","R-HSA-1640170 Cell Cycle;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-174143;https://reactome.org/PathwayBrowser/#/R-HSA-174154;https://reactome.org/PathwayBrowser/#/R-HSA-174178;https://reactome.org/PathwayBrowser/#/R-HSA-176409;https://reactome.org/PathwayBrowser/#/R-HSA-176814;https://reactome.org/PathwayBrowser/#/R-HSA-2467813;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-453276;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278","E2F TARGETS;G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["P00338","L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2","LDHA",1.076069883,0.018531978,"nochange",344050,332271,342295,358999,376898,360205,0.976158523,0.942738464,0.971179136,1.018572689,1.069356765,1.021994422,"cytoplasm","K00016","LDH; L-lactate dehydrogenase [EC:1.1.1.27]","hsa00270 Cysteine and methionine metabolism; hsa04066 HIF-1 signaling pathway; hsa04922 Glucagon signaling pathway; hsa00620 Pyruvate metabolism; hsa00010 Glycolysis / Gluconeogenesis; hsa00640 Propanoate metabolism; hsa01100 Metabolic pathways; hsa05230 Central carbon metabolism in cancer","GO:0000302 response to reactive oxygen species; GO:0000768 syncytium formation by plasma membrane fusion; GO:0001666 response to hypoxia; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006006 glucose metabolic process; GO:0006007 glucose catabolic process; GO:0006082 organic acid metabolic process; GO:0006089 lactate metabolic process; GO:0006090 pyruvate metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006096 glycolytic process; GO:0006113 fermentation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006165 nucleoside diphosphate phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006734 NADH metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006754 ATP biosynthetic process; GO:0006757 ATP generation from ADP; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006949 syncytium formation; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0007520 myoblast fusion; GO:0007525 somatic muscle development; GO:0007584 response to nutrient; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009132 nucleoside diphosphate metabolic process; GO:0009135 purine nucleoside diphosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009142 nucleoside triphosphate biosynthetic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009145 purine nucleoside triphosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009166 nucleotide catabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009179 purine ribonucleoside diphosphate metabolic process; GO:0009185 ribonucleoside diphosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009201 ribonucleoside triphosphate biosynthetic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009206 purine ribonucleoside triphosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010243 response to organonitrogen compound; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0014902 myotube differentiation; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016052 carbohydrate catabolic process; GO:0016053 organic acid biosynthetic process; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019244 lactate biosynthetic process from pyruvate; GO:0019249 lactate biosynthetic process; GO:0019318 hexose metabolic process; GO:0019320 hexose catabolic process; GO:0019359 nicotinamide nucleotide biosynthetic process; GO:0019362 pyridine nucleotide metabolic process; GO:0019363 pyridine nucleotide biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019659 glucose catabolic process to lactate; GO:0019660 glycolytic fermentation; GO:0019661 glucose catabolic process to lactate via pyruvate; GO:0019666 nitrogenous compound fermentation; GO:0019674 NAD metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0030154 cell differentiation; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0034284 response to monosaccharide; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0036293 response to decreased oxygen levels; GO:0042221 response to chemical; GO:0042542 response to hydrogen peroxide; GO:0042692 muscle cell differentiation; GO:0042866 pyruvate biosynthetic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043436 oxoacid metabolic process; GO:0043627 response to estrogen; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0046031 ADP metabolic process; GO:0046034 ATP metabolic process; GO:0046365 monosaccharide catabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0046677 response to antibiotic; GO:0046683 response to organophosphorus; GO:0046700 heterocycle catabolic process; GO:0046939 nucleotide phosphorylation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048569 post-embryonic animal organ development; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051146 striated muscle cell differentiation; GO:0051591 response to cAMP; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072524 pyridine-containing compound metabolic process; GO:0072525 pyridine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0005929 cilium; GO:0016020 membrane; GO:0031514 motile cilium; GO:0031974 membrane-enclosed lumen; GO:0035686 sperm fibrous sheath; GO:0036126 sperm flagellum; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045121 membrane raft; GO:0070013 intracellular organelle lumen; GO:0097729 9+2 motile cilium; GO:0098857 membrane microdomain; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004457 lactate dehydrogenase activity; GO:0004459 L-lactate dehydrogenase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0051287 NAD binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00056; PF02866","PF00056 lactate/malate dehydrogenase"," NAD binding domain; PF02866 lactate/malate dehydrogenase"," alpha/beta C-terminal domain","C","KOG1495","Lactate dehydrogenase","WP4629 AEROBIC GLYCOLYSIS;WP3925 AMINO ACID METABOLISM;WP5097 CCL18 SIGNALING PATHWAY;WP4018 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS;WP1946 CORI CYCLE;WP534 GLYCOLYSIS AND GLUCONEOGENESIS;WP5049 GLYCOLYSIS IN SENESCENCE;WP4206 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY;WP2456 HIF1A AND PPARG REGULATION OF GLYCOLYSIS;WP4290 METABOLIC REPROGRAMMING IN COLON CANCER;WP5094 OREXIN RECEPTOR PATHWAY;WP3614 PHOTODYNAMIC THERAPYINDUCED HIF1 SURVIVAL SIGNALING;WP4141 PI3KAKTMTOR VITD3 SIGNALING;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4629_r119264;http://www.wikipathways.org/instance/WP3925_r117062;http://www.wikipathways.org/instance/WP5097_r119075;http://www.wikipathways.org/instance/WP4018_r117168;http://www.wikipathways.org/instance/WP1946_r119982;http://www.wikipathways.org/instance/WP534_r117147;http://www.wikipathways.org/instance/WP5049_r120508;http://www.wikipathways.org/instance/WP4206_r119286;http://www.wikipathways.org/instance/WP2456_r119185;http://www.wikipathways.org/instance/WP4290_r118611;http://www.wikipathways.org/instance/WP5094_r120665;http://www.wikipathways.org/instance/WP3614_r106542;http://www.wikipathways.org/instance/WP4141_r116420;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-70268 Pyruvate metabolism;R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70268;https://reactome.org/PathwayBrowser/#/R-HSA-71406","FATTY ACID METABOLISM;GLYCOLYSIS;HYPOXIA;MTORC1 SIGNALING;MYC TARGETS V1;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P00403","Cytochrome c oxidase subunit 2 OS=Homo sapiens OX=9606 GN=MT-CO2 PE=1 SV=1","MT-CO2",1.367991063,1.522736E-3,"up",227795,210609,213264,313082,298509,279885,0.885704769,0.818882748,0.829205829,1.217314781,1.160652538,1.088239335,"plasma membrane","K02261","COX2; cytochrome c oxidase subunit 2","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04260 Cardiac muscle contraction; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006123 mitochondrial electron transport"," cytochrome c to oxygen; GO:0006139 nucleobase-containing compound metabolic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0007275 multicellular organism development; GO:0007589 body fluid secretion; GO:0007595 lactation; GO:0008152 metabolic process; GO:0009060 aerobic respiration; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009266 response to temperature stimulus; GO:0009409 response to cold; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010310 regulation of hydrogen peroxide metabolic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010726 positive regulation of hydrogen peroxide metabolic process; GO:0010728 regulation of hydrogen peroxide biosynthetic process; GO:0010729 positive regulation of hydrogen peroxide biosynthetic process; GO:0010939 regulation of necrotic cell death; GO:0010940 positive regulation of necrotic cell death; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016310 phosphorylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019646 aerobic electron transport chain; GO:0019693 ribose phosphate metabolic process; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030810 positive regulation of nucleotide biosynthetic process; GO:0030879 mammary gland development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034220 ion transmembrane transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045981 positive regulation of nucleotide metabolic process; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0062012 regulation of small molecule metabolic process; GO:0062013 positive regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0080090 regulation of primary metabolic process; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900373 positive regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1900544 positive regulation of purine nucleotide metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902600 proton transmembrane transport; GO:1903426 regulation of reactive oxygen species biosynthetic process; GO:1903428 positive regulation of reactive oxygen species biosynthetic process; GO:1903578 regulation of ATP metabolic process; GO:1903580 positive regulation of ATP metabolic process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process; GO:2001169 regulation of ATP biosynthetic process; GO:2001171 positive regulation of ATP biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005751 mitochondrial respiratory chain complex IV; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045277 respiratory chain complex IV; GO:0070069 cytochrome complex; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex;","GO:0003824 catalytic activity; GO:0004129 cytochrome-c oxidase activity; GO:0005215 transporter activity; GO:0008324 cation transmembrane transporter activity; GO:0009055 electron transfer activity; GO:0015075 ion transmembrane transporter activity; GO:0015078 proton transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0016491 oxidoreductase activity; GO:0016675 oxidoreductase activity"," acting on a heme group of donors; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity;","PF00116","PF00116 Cytochrome C oxidase subunit II"," periplasmic domain","C","KOG4767","Cytochrome c oxidase"," subunit II"," and related proteins",{"$nulls":3},"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5628897 TP53 Regulates Metabolic Genes;R-HSA-611105 Respiratory electron transport;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953897 Cellular responses to stimuli;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5628897;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9711123"]
["P00742","Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=2","F10",1.805031608,0.000786776,"up",14186.1,17023.3,15439.7,26809,30188.6,27205.5,0.650478937,0.780573808,0.707960585,1.229280058,1.384245737,1.247460876,"extracellular","K01314","F10; coagulation factor X [EC:3.4.21.6]","hsa04610 Complement and coagulation cascades","GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006950 response to stress; GO:0007596 blood coagulation; GO:0007598 blood coagulation"," extrinsic pathway; GO:0007599 hemostasis; GO:0008152 metabolic process; GO:0009611 response to wounding; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016192 vesicle-mediated transport; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0032501 multicellular organismal process; GO:0032879 regulation of localization; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042060 wound healing; GO:0043170 macromolecule metabolic process; GO:0044238 primary metabolic process; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0072376 protein activation cascade; GO:0072378 blood coagulation"," fibrin clot formation; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005794 Golgi apparatus; GO:0005796 Golgi lumen; GO:0005886 plasma membrane; GO:0009897 external side of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031233 intrinsic component of external side of plasma membrane; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098552 side of membrane;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004252 serine-type endopeptidase activity; GO:0005488 binding; GO:0005543 phospholipid binding; GO:0008233 peptidase activity; GO:0008236 serine-type peptidase activity; GO:0008289 lipid binding; GO:0016787 hydrolase activity; GO:0017171 serine hydrolase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0140096 catalytic activity"," acting on a protein;","PF00594; PF00008; PF14670; PF00089","PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; PF00008 EGF-like domain; PF14670 Coagulation Factor Xa inhibitory site; PF00089 Trypsin",{"$nulls":3},"WP4583 BIOMARKERS FOR UREA CYCLE DISORDERS;WP272 BLOOD CLOTTING CASCADE;WP558 COMPLEMENT AND COAGULATION CASCADES;WP2806 COMPLEMENT SYSTEM","http://www.wikipathways.org/instance/WP4583_r106803;http://www.wikipathways.org/instance/WP272_r118424;http://www.wikipathways.org/instance/WP558_r119232;http://www.wikipathways.org/instance/WP2806_r116569","Transcription factor","R-HSA-109582 Hemostasis;R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation;R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation;R-HSA-140875 Common Pathway of Fibrin Clot Formation;R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade);R-HSA-159740 Gamma-carboxylation of protein precursors;R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins;R-HSA-159854 Gamma-carboxylation"," transport"," and amino-terminal cleavage of proteins;R-HSA-163841 Gamma carboxylation"," hypusine formation and arylsulfatase activation;R-HSA-1643685 Disease;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS);R-HSA-9662001 Defective factor VIII causes hemophilia A;R-HSA-9668250 Defective factor IX causes hemophilia B;R-HSA-9671793 Diseases of hemostasis;R-HSA-9672383 Defective factor IX causes thrombophilia;R-HSA-9672396 Defective cofactor function of FVIIIa variant;R-HSA-9673202 Defective F9 variant does not activate FX","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-140834;https://reactome.org/PathwayBrowser/#/R-HSA-140837;https://reactome.org/PathwayBrowser/#/R-HSA-140875;https://reactome.org/PathwayBrowser/#/R-HSA-140877;https://reactome.org/PathwayBrowser/#/R-HSA-159740;https://reactome.org/PathwayBrowser/#/R-HSA-159763;https://reactome.org/PathwayBrowser/#/R-HSA-159782;https://reactome.org/PathwayBrowser/#/R-HSA-159854;https://reactome.org/PathwayBrowser/#/R-HSA-163841;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-9651496;https://reactome.org/PathwayBrowser/#/R-HSA-9662001;https://reactome.org/PathwayBrowser/#/R-HSA-9668250;https://reactome.org/PathwayBrowser/#/R-HSA-9671793;https://reactome.org/PathwayBrowser/#/R-HSA-9672383;https://reactome.org/PathwayBrowser/#/R-HSA-9672396;https://reactome.org/PathwayBrowser/#/R-HSA-9673202","COAGULATION;COMPLEMENT;XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COAGULATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["P01040","Cystatin-A OS=Homo sapiens OX=9606 GN=CSTA PE=1 SV=1","CSTA",0.699451953,0.149341256,"nochange",4417.01,2931.29,2971.98,2500.16,"NA",2312.2,1.459431401,0.968532259,0.981976707,0.8260819,"NA",0.763977733,"cytoplasm","K13907",null,null,"GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0007155 cell adhesion; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008544 epidermis development; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009913 epidermal cell differentiation; GO:0009987 cellular process; GO:0010466 negative regulation of peptidase activity; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010951 negative regulation of endopeptidase activity; GO:0012501 programmed cell death; GO:0018149 peptide cross-linking; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022610 biological adhesion; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030216 keratinocyte differentiation; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031424 keratinization; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0036211 protein modification process; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043588 skin development; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045861 negative regulation of proteolysis; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070268 cornification; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0098609 cell-cell adhesion; GO:1901564 organonitrogen compound metabolic process;","GO:0001533 cornified envelope; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0002020 protease binding; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0004869 cysteine-type endopeptidase inhibitor activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0030674 protein-macromolecule adaptor activity; GO:0060090 molecular adaptor activity; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0098772 molecular function regulator;","PF00031","PF00031 Cystatin domain",{"$nulls":6},"R-HSA-1266738 Developmental Biology;R-HSA-6805567 Keratinization;R-HSA-6809371 Formation of the cornified envelope","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-6805567;https://reactome.org/PathwayBrowser/#/R-HSA-6809371"]
["P02768","Albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2","ALB",1.441492807,0.033013863,"nochange",52371.3,44700.2,58691.4,84459.5,76374.8,63696.8,0.826275986,0.705246993,0.925989892,1.332540087,1.204985616,1.004961425,"extracellular","K16141","ALB; serum albumin","hsa04918 Thyroid hormone synthesis","GO:0001897 cytolysis by symbiont of host cells; GO:0001906 cell killing; GO:0001907 killing by symbiont of host cells; GO:0002576 platelet degranulation; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007584 response to nutrient; GO:0008015 blood circulation; GO:0008152 metabolic process; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019538 protein metabolic process; GO:0019835 cytolysis; GO:0019836 hemolysis by symbiont of host erythrocytes; GO:0031640 killing of cells of another organism; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032501 multicellular organismal process; GO:0032940 secretion by cell; GO:0033189 response to vitamin A; GO:0033273 response to vitamin; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034367 protein-containing complex remodeling; GO:0034368 protein-lipid complex remodeling; GO:0034369 plasma lipoprotein particle remodeling; GO:0034375 high-density lipoprotein particle remodeling; GO:0035150 regulation of tube size; GO:0035296 regulation of tube diameter; GO:0035821 modulation of process of another organism; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0042311 vasodilation; GO:0042594 response to starvation; GO:0042749 regulation of circadian sleep/wake cycle; GO:0042752 regulation of circadian rhythm; GO:0042753 positive regulation of circadian rhythm; GO:0042981 regulation of apoptotic process; GO:0043062 extracellular structure organization; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044003 modulation by symbiont of host process; GO:0044179 hemolysis in another organism; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044364 disruption of cells of another organism; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044764 multi-organism cellular process; GO:0045055 regulated exocytosis; GO:0045187 regulation of circadian sleep/wake cycle"," sleep; GO:0045188 regulation of circadian sleep/wake cycle"," non-REM sleep; GO:0045938 positive regulation of circadian sleep/wake cycle"," sleep; GO:0046010 positive regulation of circadian sleep/wake cycle"," non-REM sleep; GO:0046689 response to mercury ion; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048520 positive regulation of behavior; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051651 maintenance of location in cell; GO:0051657 maintenance of organelle location; GO:0051659 maintenance of mitochondrion location; GO:0051701 biological process involved in interaction with host; GO:0051707 response to other organism; GO:0051715 cytolysis in another organism; GO:0051716 cellular response to stimulus; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070541 response to platinum ion; GO:0070887 cellular response to chemical stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071825 protein-lipid complex subunit organization; GO:0071827 plasma lipoprotein particle organization; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0097006 regulation of plasma lipoprotein particle levels; GO:0097237 cellular response to toxic substance; GO:0097746 blood vessel diameter maintenance; GO:0098657 import into cell; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1901564 organonitrogen compound metabolic process; GO:1990748 cellular detoxification;","GO:0005576 extracellular region; GO:0005604 basement membrane; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031012 extracellular matrix; GO:0031091 platelet alpha granule; GO:0031093 platelet alpha granule lumen; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0060417 yolk; GO:0062023 collagen-containing extracellular matrix; GO:0070013 intracellular organelle lumen; GO:0070062 extracellular exosome; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:1903561 extracellular vesicle;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0005488 binding; GO:0005504 fatty acid binding; GO:0005507 copper ion binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0008289 lipid binding; GO:0015643 toxic substance binding; GO:0016209 antioxidant activity; GO:0019842 vitamin binding; GO:0019899 enzyme binding; GO:0030170 pyridoxal phosphate binding; GO:0031406 carboxylic acid binding; GO:0033293 monocarboxylic acid binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043177 organic acid binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051087 chaperone binding; GO:0070279 vitamin B6 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00273","PF00273 Serum albumin family",{"$nulls":3},"WP2806 COMPLEMENT SYSTEM;WP176 FOLATE METABOLISM;WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY;WP15 SELENIUM MICRONUTRIENT NETWORK;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY;WP1533 VITAMIN B12 METABOLISM","http://www.wikipathways.org/instance/WP2806_r116569;http://www.wikipathways.org/instance/WP176_r120275;http://www.wikipathways.org/instance/WP5115_r120597;http://www.wikipathways.org/instance/WP15_r118387;http://www.wikipathways.org/instance/WP3888_r116782;http://www.wikipathways.org/instance/WP1533_r116401",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-1430728 Metabolism;R-HSA-159418 Recycling of bile acids and salts;R-HSA-174824 Plasma lipoprotein assembly"," remodeling"," and clearance;R-HSA-189445 Metabolism of porphyrins;R-HSA-189451 Heme biosynthesis;R-HSA-189483 Heme degradation;R-HSA-194068 Bile acid and bile salt metabolism;R-HSA-2168880 Scavenging of heme from plasma;R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors;R-HSA-2262752 Cellular responses to stress;R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);R-HSA-382551 Transport of small molecules;R-HSA-392499 Metabolism of proteins;R-HSA-556833 Metabolism of lipids;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-8953897 Cellular responses to stimuli;R-HSA-8957275 Post-translational protein phosphorylation;R-HSA-8957322 Metabolism of steroids;R-HSA-8963899 Plasma lipoprotein remodeling;R-HSA-8964058 HDL remodeling;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9748784 Drug ADME;R-HSA-9749641 Aspirin ADME","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-159418;https://reactome.org/PathwayBrowser/#/R-HSA-174824;https://reactome.org/PathwayBrowser/#/R-HSA-189445;https://reactome.org/PathwayBrowser/#/R-HSA-189451;https://reactome.org/PathwayBrowser/#/R-HSA-189483;https://reactome.org/PathwayBrowser/#/R-HSA-194068;https://reactome.org/PathwayBrowser/#/R-HSA-2168880;https://reactome.org/PathwayBrowser/#/R-HSA-2173782;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-381426;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-8957275;https://reactome.org/PathwayBrowser/#/R-HSA-8957322;https://reactome.org/PathwayBrowser/#/R-HSA-8963899;https://reactome.org/PathwayBrowser/#/R-HSA-8964058;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9711123;https://reactome.org/PathwayBrowser/#/R-HSA-9748784;https://reactome.org/PathwayBrowser/#/R-HSA-9749641","PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["P04062","Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA1 PE=1 SV=3","GBA1",1.169985382,0.00087501,"up",7419.1,7492.78,7499.4,8449.69,8947.51,8823.67,0.915332758,0.924423041,0.925239785,1.04248198,1.103900609,1.088621827,"extracellular","K01201","GBA; glucosylceramidase [EC:3.2.1.45]","hsa04142 Lysosome; hsa00600 Sphingolipid metabolism; hsa00511 Other glycan degradation; hsa01100 Metabolic pathways","GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0003008 system process; GO:0006066 alcohol metabolic process; GO:0006469 negative regulation of protein kinase activity; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006664 glycolipid metabolic process; GO:0006665 sphingolipid metabolic process; GO:0006670 sphingosine metabolic process; GO:0006672 ceramide metabolic process; GO:0006677 glycosylceramide metabolic process; GO:0006678 glucosylceramide metabolic process; GO:0006680 glucosylceramide catabolic process; GO:0006687 glycosphingolipid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006914 autophagy; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0007033 vacuole organization; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0008344 adult locomotory behavior; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009267 cellular response to starvation; GO:0009268 response to pH; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010259 multicellular organism aging; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016137 glycoside metabolic process; GO:0016139 glycoside catabolic process; GO:0016236 macroautophagy; GO:0016241 regulation of macroautophagy; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019377 glycolipid catabolic process; GO:0019725 cellular homeostasis; GO:0019751 polyol metabolic process; GO:0023021 termination of signal transduction; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030104 water homeostasis; GO:0030148 sphingolipid biosynthetic process; GO:0030149 sphingolipid catabolic process; GO:0030162 regulation of proteolysis; GO:0030534 adult behavior; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031644 regulation of nervous system process; GO:0031646 positive regulation of nervous system process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0031960 response to corticosteroid; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032459 regulation of protein oligomerization; GO:0032460 negative regulation of protein oligomerization; GO:0032462 regulation of protein homooligomerization; GO:0032463 negative regulation of protein homooligomerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032675 regulation of interleukin-6 production; GO:0032715 negative regulation of interleukin-6 production; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0033561 regulation of water loss via skin; GO:0033574 response to testosterone; GO:0033673 negative regulation of kinase activity; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034311 diol metabolic process; GO:0034312 diol biosynthetic process; GO:0034612 response to tumor necrosis factor; GO:0034620 cellular response to unfolded protein; GO:0034641 cellular nitrogen compound metabolic process; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035306 positive regulation of dephosphorylation; GO:0035307 positive regulation of protein dephosphorylation; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042391 regulation of membrane potential; GO:0042592 homeostatic process; GO:0042594 response to starvation; GO:0043086 negative regulation of catalytic activity; GO:0043243 positive regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043549 regulation of kinase activity; GO:0043588 skin development; GO:0043589 skin morphogenesis; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043627 response to estrogen; GO:0044057 regulation of system process; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045732 positive regulation of protein catabolic process; GO:0045760 positive regulation of action potential; GO:0045859 regulation of protein kinase activity; GO:0045862 positive regulation of proteolysis; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046165 alcohol biosynthetic process; GO:0046173 polyol biosynthetic process; GO:0046466 membrane lipid catabolic process; GO:0046467 membrane lipid biosynthetic process; GO:0046477 glycosylceramide catabolic process; GO:0046479 glycosphingolipid catabolic process; GO:0046512 sphingosine biosynthetic process; GO:0046513 ceramide biosynthetic process; GO:0046514 ceramide catabolic process; GO:0046519 sphingoid metabolic process; GO:0046520 sphingoid biosynthetic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048871 multicellular organismal homeostasis; GO:0048878 chemical homeostasis; GO:0050727 regulation of inflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050746 regulation of lipoprotein metabolic process; GO:0050747 positive regulation of lipoprotein metabolic process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050878 regulation of body fluid levels; GO:0050890 cognition; GO:0050891 multicellular organismal water homeostasis; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051384 response to glucocorticoid; GO:0051716 cellular response to stimulus; GO:0051969 regulation of transmission of nerve impulse; GO:0051971 positive regulation of transmission of nerve impulse; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070050 neuron cellular homeostasis; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071356 cellular response to tumor necrosis factor; GO:0071496 cellular response to external stimulus; GO:0071548 response to dexamethasone; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0097066 response to thyroid hormone; GO:0097164 ammonium ion metabolic process; GO:0097327 response to antineoplastic agent; GO:0098780 response to mitochondrial depolarisation; GO:0098900 regulation of action potential; GO:0098908 regulation of neuronal action potential; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1901654 response to ketone; GO:1901657 glycosyl compound metabolic process; GO:1901658 glycosyl compound catabolic process; GO:1901700 response to oxygen-containing compound; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901804 beta-glucoside metabolic process; GO:1901805 beta-glucoside catabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903059 regulation of protein lipidation; GO:1903061 positive regulation of protein lipidation; GO:1903146 regulation of autophagy of mitochondrion; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903509 liposaccharide metabolic process; GO:1903599 positive regulation of autophagy of mitochondrion; GO:1904350 regulation of protein catabolic process in the vacuole; GO:1904457 positive regulation of neuronal action potential; GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization; GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; GO:1905037 autophagosome organization; GO:1905165 regulation of lysosomal protein catabolic process; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005775 vacuolar lumen; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0031090 organelle membrane; GO:0031974 membrane-enclosed lumen; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane;","GO:0003824 catalytic activity; GO:0004348 glucosylceramidase activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0005102 signaling receptor binding; GO:0005124 scavenger receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds;","PF02055; PF17189","PF02055 Glycosyl hydrolase family 30 TIM-barrel domain; PF17189 Glycosyl hydrolase family 30 beta sandwich domain","G","KOG2566","Beta-glucocerebrosidase","WP5121 SPHINGOLIPID METABOLISM IN SENESCENCE;WP1422 SPHINGOLIPID PATHWAY","http://www.wikipathways.org/instance/WP5121_r119472;http://www.wikipathways.org/instance/WP1422_r118359",null,"R-HSA-1430728 Metabolism;R-HSA-1660662 Glycosphingolipid metabolism;R-HSA-390466 Chaperonin-mediated protein folding;R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins;R-HSA-428157 Sphingolipid metabolism;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1660662;https://reactome.org/PathwayBrowser/#/R-HSA-390466;https://reactome.org/PathwayBrowser/#/R-HSA-390471;https://reactome.org/PathwayBrowser/#/R-HSA-391251;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-428157;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["P04183","Thymidine kinase"," cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2","TK1",1.099089226,0.139639728,"nochange",38768.2,36885.8,43519.4,44655.4,44281.6,42045.2,0.929858056,0.884708557,1.043815929,1.07106297,1.062097351,1.008457136,"cytoplasm","K00857","tdk; thymidine kinase [EC:2.7.1.21]","hsa00983 Drug metabolism - other enzymes; hsa00240 Pyrimidine metabolism; hsa01232 Nucleotide metabolism; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0001889 liver development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006213 pyrimidine nucleoside metabolic process; GO:0006259 DNA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007567 parturition; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008655 pyrimidine-containing compound salvage; GO:0009058 biosynthetic process; GO:0009116 nucleoside metabolic process; GO:0009117 nucleotide metabolic process; GO:0009120 deoxyribonucleoside metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009157 deoxyribonucleoside monophosphate biosynthetic process; GO:0009162 deoxyribonucleoside monophosphate metabolic process; GO:0009163 nucleoside biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009605 response to external stimulus; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0014070 response to organic cyclic compound; GO:0014855 striated muscle cell proliferation; GO:0014856 skeletal muscle cell proliferation; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0031667 response to nutrient levels; GO:0031960 response to corticosteroid; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033002 muscle cell proliferation; GO:0033993 response to lipid; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035295 tube development; GO:0042221 response to chemical; GO:0043094 cellular metabolic compound salvage; GO:0043097 pyrimidine nucleoside salvage; GO:0043170 macromolecule metabolic process; GO:0043174 nucleoside salvage; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0046104 thymidine metabolic process; GO:0046125 pyrimidine deoxyribonucleoside metabolic process; GO:0046134 pyrimidine nucleoside biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046688 response to copper ion; GO:0048513 animal organ development; GO:0048545 response to steroid hormone; GO:0048565 digestive tract development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051262 protein tetramerization; GO:0051289 protein homotetramerization; GO:0051384 response to glucocorticoid; GO:0051414 response to cortisol; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0055123 digestive system development; GO:0060138 fetal process involved in parturition; GO:0061008 hepaticobiliary system development; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072527 pyrimidine-containing compound metabolic process; GO:0072528 pyrimidine-containing compound biosynthetic process; GO:0090304 nucleic acid metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097305 response to alcohol; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901654 response to ketone; GO:1901657 glycosyl compound metabolic process; GO:1901659 glycosyl compound biosynthetic process; GO:1901700 response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004797 thymidine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0019136 deoxynucleoside kinase activity; GO:0019205 nucleobase-containing compound kinase activity; GO:0019206 nucleoside kinase activity; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding;",null,null,"F","KOG3125","Thymidine kinase","WP1601 FLUOROPYRIMIDINE ACTIVITY;WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP1601_r120496;http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-1640170 Cell Cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-69205 G1/S-Specific Transcription;R-HSA-69206 G1/S Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-73614 Pyrimidine salvage;R-HSA-8956321 Nucleotide salvage","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-453279;https://reactome.org/PathwayBrowser/#/R-HSA-69205;https://reactome.org/PathwayBrowser/#/R-HSA-69206;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-73614;https://reactome.org/PathwayBrowser/#/R-HSA-8956321","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["P04844","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Homo sapiens OX=9606 GN=RPN2 PE=1 SV=3","RPN2",1.055813533,0.279290747,"nochange",123245,113621,117170,126091,131375,116330,1.015989954,0.936652964,0.965909715,1.039451412,1.083010915,0.958985041,"extracellular","K12667","SWP1; oligosaccharyltransferase complex subunit delta (ribophorin II)","hsa00510 N-Glycan biosynthesis; hsa00513 Various types of N-glycan biosynthesis; hsa04141 Protein processing in endoplasmic reticulum; hsa01100 Metabolic pathways","GO:0002252 immune effector process; GO:0002376 immune system process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006487 protein N-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007568 aging; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0016043 cellular component organization; GO:0018193 peptidyl-amino acid modification; GO:0018196 peptidyl-asparagine modification; GO:0018279 protein N-linked glycosylation via asparagine; GO:0019538 protein metabolic process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035010 encapsulation of foreign target; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051302 regulation of cell division; GO:0065007 biological regulation; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000421 autophagosome membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005776 autophagosome; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005791 rough endoplasmic reticulum; GO:0008250 oligosaccharyltransferase complex; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0005488 binding; GO:0043021 ribonucleoprotein complex binding; GO:0043022 ribosome binding; GO:0044877 protein-containing complex binding;",null,null,"O","KOG2447","Oligosaccharyltransferase"," delta subunit (ribophorin II)","WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-1643685 Disease;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-72766 Translation;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694548 Maturation of spike protein;R-HSA-9694635 Translation of Structural Proteins;R-HSA-9772573 Late SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1799339;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-72766;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694548;https://reactome.org/PathwayBrowser/#/R-HSA-9694635;https://reactome.org/PathwayBrowser/#/R-HSA-9772573"]
["P05106","Integrin beta-3 OS=Homo sapiens OX=9606 GN=ITGB3 PE=1 SV=2","ITGB3",0.952608351,0.201576036,"nochange",28841.8,30631.1,30279.2,29450.1,27047.4,29001.1,0.987447126,1.048706795,1.036658912,1.008273291,0.926012849,0.992901027,"plasma membrane","K06493","ITGB3; integrin beta 3","hsa04380 Osteoclast differentiation; hsa04510 Focal adhesion; hsa05412 Arrhythmogenic right ventricular cardiomyopathy; hsa04919 Thyroid hormone signaling pathway; hsa05418 Fluid shear stress and atherosclerosis; hsa04512 ECM-receptor interaction; hsa05168 Herpes simplex virus 1 infection; hsa05165 Human papillomavirus infection; hsa05205 Proteoglycans in cancer; hsa05206 MicroRNAs in cancer; hsa04015 Rap1 signaling pathway; hsa05414 Dilated cardiomyopathy; hsa04640 Hematopoietic cell lineage; hsa05410 Hypertrophic cardiomyopathy; hsa04613 Neutrophil extracellular trap formation; hsa03266 Virion - Herpesvirus; hsa05163 Human cytomegalovirus infection; hsa04810 Regulation of actin cytoskeleton; hsa04145 Phagosome; hsa04151 PI3K-Akt signaling pathway; hsa04611 Platelet activation","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001667 ameboidal-type cell migration; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001703 gastrulation with mouth forming first; GO:0001704 formation of primary germ layer; GO:0001706 endoderm formation; GO:0001707 mesoderm formation; GO:0001708 cell fate specification; GO:0001774 microglial cell activation; GO:0001775 cell activation; GO:0001894 tissue homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001936 regulation of endothelial cell proliferation; GO:0001938 positive regulation of endothelial cell proliferation; GO:0001944 vasculature development; GO:0001952 regulation of cell-matrix adhesion; GO:0001954 positive regulation of cell-matrix adhesion; GO:0002009 morphogenesis of an epithelium; GO:0002011 morphogenesis of an epithelial sheet; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002218 activation of innate immune response; GO:0002221 pattern recognition receptor signaling pathway; GO:0002224 toll-like receptor signaling pathway; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002576 platelet degranulation; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002685 regulation of leukocyte migration; GO:0002687 positive regulation of leukocyte migration; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002703 regulation of leukocyte mediated immunity; GO:0002705 positive regulation of leukocyte mediated immunity; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0002763 positive regulation of myeloid leukocyte differentiation; GO:0002764 immune response-regulating signaling pathway; GO:0002886 regulation of myeloid leukocyte mediated immunity; GO:0002888 positive regulation of myeloid leukocyte mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003344 pericardium morphogenesis; GO:0006810 transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006909 phagocytosis; GO:0006911 phagocytosis"," engulfment; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006929 substrate-dependent cell migration; GO:0006930 substrate-dependent cell migration"," cell extension; GO:0006935 chemotaxis; GO:0006937 regulation of muscle contraction; GO:0006940 regulation of smooth muscle contraction; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006968 cellular defense response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007044 cell-substrate junction assembly; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules; GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; GO:0007159 leukocyte cell-cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007161 calcium-independent cell-matrix adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007369 gastrulation; GO:0007377 germ-band extension; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007419 ventral cord development; GO:0007424 open tracheal system development; GO:0007426 tracheal outgrowth"," open tracheal system; GO:0007427 epithelial cell migration"," open tracheal system; GO:0007431 salivary gland development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007475 apposition of dorsal and ventral imaginal disc-derived wing surfaces; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007483 genital disc morphogenesis; GO:0007484 imaginal disc-derived genitalia development; GO:0007485 imaginal disc-derived male genitalia development; GO:0007492 endoderm development; GO:0007494 midgut development; GO:0007498 mesoderm development; GO:0007507 heart development; GO:0007508 larval heart development; GO:0007517 muscle organ development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007568 aging; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007600 sensory perception; GO:0007606 sensory perception of chemical stimulus; GO:0007608 sensory perception of smell; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008284 positive regulation of cell population proliferation; GO:0008340 determination of adult lifespan; GO:0008360 regulation of cell shape; GO:0008587 imaginal disc-derived wing margin morphogenesis; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010004 gastrulation involving germ band extension; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010324 membrane invagination; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010522 regulation of calcium ion transport into cytosol; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010669 epithelial structure maintenance; GO:0010710 regulation of collagen catabolic process; GO:0010712 regulation of collagen metabolic process; GO:0010720 positive regulation of cell development; GO:0010743 regulation of macrophage derived foam cell differentiation; GO:0010745 negative regulation of macrophage derived foam cell differentiation; GO:0010762 regulation of fibroblast migration; GO:0010763 positive regulation of fibroblast migration; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0010883 regulation of lipid storage; GO:0010888 negative regulation of lipid storage; GO:0010911 regulation of isomerase activity; GO:0010912 positive regulation of isomerase activity; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0012501 programmed cell death; GO:0014812 muscle cell migration; GO:0014909 smooth muscle cell migration; GO:0014910 regulation of smooth muscle cell migration; GO:0014911 positive regulation of smooth muscle cell migration; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016203 muscle attachment; GO:0016331 morphogenesis of embryonic epithelium; GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; GO:0016340 calcium-dependent cell-matrix adhesion; GO:0016477 cell migration; GO:0017157 regulation of exocytosis; GO:0019058 viral life cycle; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0021551 central nervous system morphogenesis; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030003 cellular cation homeostasis; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030032 lamellipodium assembly; GO:0030036 actin cytoskeleton organization; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030168 platelet activation; GO:0030182 neuron differentiation; GO:0030183 B cell differentiation; GO:0030198 extracellular matrix organization; GO:0030239 myofibril assembly; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030539 male genitalia development; GO:0030593 neutrophil chemotaxis; GO:0030595 leukocyte chemotaxis; GO:0030707 ovarian follicle cell development; GO:0030718 germ-line stem cell population maintenance; GO:0030855 epithelial cell differentiation; GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway; GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway; GO:0031032 actomyosin structure organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031589 cell-substrate adhesion; GO:0031623 receptor internalization; GO:0032147 activation of protein kinase activity; GO:0032231 regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032368 regulation of lipid transport; GO:0032369 negative regulation of lipid transport; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032928 regulation of superoxide anion generation; GO:0032930 positive regulation of superoxide anion generation; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033238 regulation of cellular amine metabolic process; GO:0033239 negative regulation of cellular amine metabolic process; GO:0033627 cell adhesion mediated by integrin; GO:0033628 regulation of cell adhesion mediated by integrin; GO:0033630 positive regulation of cell adhesion mediated by integrin; GO:0033631 cell-cell adhesion mediated by integrin; GO:0033674 positive regulation of kinase activity; GO:0033688 regulation of osteoblast proliferation; GO:0033690 positive regulation of osteoblast proliferation; GO:0034097 response to cytokine; GO:0034103 regulation of tissue remodeling; GO:0034105 positive regulation of tissue remodeling; GO:0034109 homotypic cell-cell adhesion; GO:0034113 heterotypic cell-cell adhesion; GO:0034142 toll-like receptor 4 signaling pathway; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034446 substrate adhesion-dependent cell spreading; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0035001 dorsal trunk growth"," open tracheal system; GO:0035099 hemocyte migration; GO:0035107 appendage morphogenesis; GO:0035112 genitalia morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035126 post-embryonic genitalia morphogenesis; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035160 maintenance of epithelial integrity",{"$cut":{"chars":17140,"head":" open tracheal system; GO:0035162 embryonic hemopoiesis; GO:0035215 genital disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035272 exocrine system development; GO:0035295 tube development; GO:0035987 endodermal cell differentiation; GO:0036119 response to platelet-derived growth factor; GO:0036120 cellular response to platelet-derived growth factor stimulus; GO:0036230 granulocyte activation; GO:0038027 apolipoprotein A-I-mediated signaling pathway; GO:0040007 growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0040025 vulval development; GO:0040028 regulation of vulval development; GO:0042053 regulation of dopamine metabolic process; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042060 wound healing; GO:0042069 regulation of catecholamine metabolic process; GO:0042113 B cell activation; GO:0042116 macrophage activation; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042592 homeostatic process; GO:0042692 muscle cell differentiation; GO:0042981 regulation of apoptotic process; GO:0043030 regulation of macrophage activation; GO:0043032 positive regulation of macrophage activation; GO:0043062 extracellular structure organization; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043112 receptor metabolic process; GO:0043113 receptor clustering; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043277 apoptotic cell clearance; GO:0043299 leukocyte degranulation; GO:0043300 regulation of leukocyte degranulation; GO:0043302 positive regulation of leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043313 regulation of neutrophil degranulation; GO:0043315 positive regulation of neutrophil degranulation; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043519 regulation of myosin II filament organization; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044409 entry into host; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045123 cellular extravasation; GO:0045124 regulation of bone resorption; GO:0045165 cell fate commitment; GO:0045214 sarcomere organization; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045639 positive regulation of myeloid cell differentiation; GO:0045670 regulation of osteoclast differentiation; GO:0045672 positive regulation of osteoclast differentiation; GO:0045745 positive regulation of G protein-coupled receptor signaling pathway; GO:0045765 regulation of angiogen"}},"GO:0001726 ruffle; GO:0005576 extracellular region; GO:0005604 basement membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005902 microvillus; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0005927 muscle tendon junction; GO:0008305 integrin complex; GO:0009897 external side of plasma membrane; GO:0009925 basal plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0016328 lateral plasma membrane; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030141 secretory granule; GO:0030175 filopodium; GO:0030425 dendrite; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031012 extracellular matrix; GO:0031090 organelle membrane; GO:0031091 platelet alpha granule; GO:0031092 platelet alpha granule membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031258 lamellipodium membrane; GO:0031410 cytoplasmic vesicle; GO:0031430 M band; GO:0031527 filopodium membrane; GO:0031528 microvillus membrane; GO:0031594 neuromuscular junction; GO:0031672 A band; GO:0031982 vesicle; GO:0032587 ruffle membrane; GO:0032991 protein-containing complex; GO:0034665 integrin alpha1-beta1 complex; GO:0034666 integrin alpha2-beta1 complex; GO:0034667 integrin alpha3-beta1 complex; GO:0034678 integrin alpha8-beta1 complex; GO:0034679 integrin alpha9-beta1 complex; GO:0034680 integrin alpha10-beta1 complex; GO:0034681 integrin alpha11-beta1 complex; GO:0034683 integrin alphav-beta3 complex; GO:0034687 integrin alphaL-beta2 complex; GO:0034688 integrin alphaM-beta2 complex; GO:0035579 specific granule membrane; GO:0035866 alphav-beta3 integrin-PKCalpha complex; GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex; GO:0035868 alphav-beta3 integrin-HMGB1 complex; GO:0036477 somatodendritic compartment; GO:0042383 sarcolemma; GO:0042470 melanosome; GO:0042581 specific granule; GO:0042734 presynaptic membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043034 costamere; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043235 receptor complex; GO:0043292 contractile fiber; GO:0044297 cell body; GO:0044853 plasma membrane raft; GO:0045121 membrane raft; GO:0045177 apical part of cell; GO:0045178 basal part of cell; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0048770 pigment granule; GO:0055120 striated muscle dense body; GO:0062023 collagen-containing extracellular matrix; GO:0070161 anchoring junction; GO:0070820 tertiary granule; GO:0070821 tertiary granule membrane; GO:0071062 alphav-beta3 integrin-vitronectin complex; GO:0071133 alpha9-beta1 integrin-ADAM8 complex; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097386 glial cell projection; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098636 protein complex involved in cell adhesion; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex; GO:0098857 membrane microdomain; GO:0098858 actin-based cell projection; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0101002 ficolin-1-rich granule; GO:0101003 ficolin-1-rich granule membrane; GO:0120025 plasma membrane bounded cell projection;","GO:0001540 amyloid-beta binding; GO:0001846 opsonin binding; GO:0001848 complement binding; GO:0001851 complement component C3b binding; GO:0001968 fibronectin binding; GO:0002020 protease binding; GO:0003756 protein disulfide isomerase activity; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0004888 transmembrane signaling receptor activity; GO:0005080 protein kinase C binding; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005161 platelet-derived growth factor receptor binding; GO:0005172 vascular endothelial growth factor receptor binding; GO:0005178 integrin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005518 collagen binding; GO:0008092 cytoskeletal protein binding; GO:0015026 coreceptor activity; GO:0016853 isomerase activity; GO:0016860 intramolecular oxidoreductase activity; GO:0016864 intramolecular oxidoreductase activity"," transposing S-S bonds; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030369 ICAM-3 receptor activity; GO:0031072 heat shock protein binding; GO:0033218 amide binding; GO:0038023 signaling receptor activity; GO:0042277 peptide binding; GO:0042802 identical protein binding; GO:0043184 vascular endothelial growth factor receptor 2 binding; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0050839 cell adhesion molecule binding; GO:0050840 extracellular matrix binding; GO:0060089 molecular transducer activity; GO:0070851 growth factor receptor binding; GO:0098631 cell adhesion mediator activity; GO:0098634 cell-matrix adhesion mediator activity; GO:0098639 collagen binding involved in cell-matrix adhesion; GO:0140096 catalytic activity"," acting on a protein;","PF17205; PF00362; PF18372; PF07974; PF07965; PF08725","PF17205 Integrin plexin domain; PF00362 Integrin beta chain VWA domain; PF18372 Integrin beta epidermal growth factor like domain 1; PF07974 EGF-like domain; PF07965 Integrin beta tail domain; PF08725 Integrin beta cytoplasmic domain","TW","KOG1226","Integrin beta subunit (N-terminal portion of extracellular region)","WP2118 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY;WP2806 COMPLEMENT SYSTEM;WP5090 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY;WP4217 EBOLA VIRUS INFECTION IN HOST;WP306 FOCAL ADHESION;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP2849 HEMATOPOIETIC STEM CELL DIFFERENTIATION;WP4541 HIPPOMERLIN SIGNALING DYSREGULATION;WP185 INTEGRINMEDIATED CELL ADHESION;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP4534 MECHANOREGULATION AND PATHOLOGY OF YAPTAZ VIA HIPPO AND NONHIPPO MECHANISMS;WP4560 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT;WP3301 MFAP5MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS;WP727 MONOAMINE TRANSPORT;WP322 OSTEOBLAST SIGNALING;WP12 OSTEOCLAST SIGNALING;WP1434 OSTEOPONTIN SIGNALING;WP4172 PI3KAKT SIGNALING PATHWAY;WP2572 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS;WP1455 SEROTONIN TRANSPORTER ACTIVITY;WP366 TGFBETA SIGNALING PATHWAY;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2118_r119252;http://www.wikipathways.org/instance/WP2806_r116569;http://www.wikipathways.org/instance/WP5090_r118898;http://www.wikipathways.org/instance/WP4217_r120623;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP2849_r117150;http://www.wikipathways.org/instance/WP4541_r116745;http://www.wikipathways.org/instance/WP185_r116785;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP4534_r103303;http://www.wikipathways.org/instance/WP4560_r108134;http://www.wikipathways.org/instance/WP3301_r120029;http://www.wikipathways.org/instance/WP727_r116775;http://www.wikipathways.org/instance/WP322_r117584;http://www.wikipathways.org/instance/WP12_r116896;http://www.wikipathways.org/instance/WP1434_r117813;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP2572_r119251;http://www.wikipathways.org/instance/WP1455_r117827;http://www.wikipathways.org/instance/WP366_r120697;http://www.wikipathways.org/instance/WP4746_r120402;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-1266738 Developmental Biology;R-HSA-1474244 Extracellular matrix organization;R-HSA-1566948 Elastic fibre formation;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-194138 Signaling by VEGF;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-210990 PECAM1 interactions;R-HSA-2129379 Molecules associated with elastic fibres;R-HSA-216083 Integrin cell surface interactions;R-HSA-2173789 TGF-beta receptor signaling activates SMADs;R-HSA-3000170 Syndecan interactions;R-HSA-3000171 Non-integrin membrane-ECM interactions;R-HSA-3000178 ECM proteoglycans;R-HSA-354192 Integrin signaling;R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins ;R-HSA-372708 p130Cas linkage to MAPK signaling for integrins;R-HSA-373760 L1CAM interactions;R-HSA-422475 Axon guidance;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-445144 Signal transduction by L1;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5674135 MAP2K and MAPK activation;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants;R-HSA-6802948 Signaling by high-kinase activity BRAF mutants;R-HSA-6802949 Signaling by RAS mutants;R-HSA-6802952 Signaling by BRAF and RAF1 fusions;R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF;R-HSA-6802957 Oncogenic MAPK signaling;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-76009 Platelet Aggregation (Plug Formation);R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9006936 Signaling by TGFB family members;R-HSA-9649948 Signaling downstream of RAS mutants;R-HSA-9656223 Signaling by RAF1 mutants;R-HSA-9675108 Nervous system development",null,"COAGULATION;EPITHELIAL MESENCHYMAL TRANSITION;IL6 JAK STAT3 SIGNALING;INFLAMMATORY RESPONSE;UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COAGULATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL6_JAK_STAT3_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["P05423","DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2","POLR3D",0.835601718,0.136205572,"nochange",8875.69,10992.9,9584.82,8250.77,9228.06,7132.49,0.985007046,1.21997095,1.063704933,0.915654624,1.024112393,0.791550055,"nucleus","K03026","RPC4; DNA-directed RNA polymerase III subunit RPC4","hsa04623 Cytosolic DNA-sensing pathway; hsa03020 RNA polymerase","GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032648 regulation of interferon-beta production; GO:0032728 positive regulation of interferon-beta production; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0048518 positive regulation of biological process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0065007 biological regulation; GO:0080134 regulation of response to stress;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005666 RNA polymerase III complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003682 chromatin binding; GO:0005488 binding;",null,null,"K","KOG3122","DNA-directed RNA polymerase III subunit","WP4655 CYTOSOLIC DNASENSING PATHWAY;WP405 EUKARYOTIC TRANSCRIPTION INITIATION;WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP4655_r105163;http://www.wikipathways.org/instance/WP405_r118377;http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-73780 RNA Polymerase III Chain Elongation;R-HSA-73980 RNA Polymerase III Transcription Termination;R-HSA-74158 RNA Polymerase III Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation;R-HSA-76046 RNA Polymerase III Transcription Initiation;R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter;R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter;R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1834949;https://reactome.org/PathwayBrowser/#/R-HSA-73780;https://reactome.org/PathwayBrowser/#/R-HSA-73980;https://reactome.org/PathwayBrowser/#/R-HSA-74158;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-749476;https://reactome.org/PathwayBrowser/#/R-HSA-76046;https://reactome.org/PathwayBrowser/#/R-HSA-76061;https://reactome.org/PathwayBrowser/#/R-HSA-76066;https://reactome.org/PathwayBrowser/#/R-HSA-76071"]
["P06865","Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2","HEXA",0.893358826,0.001987477,"down",52042.1,53478.5,54732.7,48271.8,47486.3,47405.6,1.02912032,1.057524793,1.082326303,0.954563521,0.939030443,0.93743462,"mitochondria","K12373","HEXA_B; hexosaminidase [EC:3.2.1.52]","hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series; hsa04142 Lysosome; hsa00600 Sphingolipid metabolism; hsa00513 Various types of N-glycan biosynthesis; hsa00531 Glycosaminoglycan degradation; hsa00604 Glycosphingolipid biosynthesis - ganglio series; hsa00511 Other glycan degradation; hsa00520 Amino sugar and nucleotide sugar metabolism; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001501 skeletal system development; GO:0001573 ganglioside metabolic process; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003008 system process; GO:0005975 carbohydrate metabolic process; GO:0006022 aminoglycan metabolic process; GO:0006023 aminoglycan biosynthetic process; GO:0006024 glycosaminoglycan biosynthetic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006029 proteoglycan metabolic process; GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006664 glycolipid metabolic process; GO:0006665 sphingolipid metabolic process; GO:0006672 ceramide metabolic process; GO:0006687 glycosphingolipid metabolic process; GO:0006689 ganglioside catabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007033 vacuole organization; GO:0007040 lysosome organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007272 ensheathment of neurons; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0007628 adult walking behavior; GO:0008152 metabolic process; GO:0008344 adult locomotory behavior; GO:0008366 axon ensheathment; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0016192 vesicle-mediated transport; GO:0019377 glycolipid catabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019915 lipid storage; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030149 sphingolipid catabolic process; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030203 glycosaminoglycan metabolic process; GO:0030204 chondroitin sulfate metabolic process; GO:0030207 chondroitin sulfate catabolic process; GO:0030212 hyaluronan metabolic process; GO:0030214 hyaluronan catabolic process; GO:0030534 adult behavior; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042339 keratan sulfate metabolic process; GO:0042340 keratan sulfate catabolic process; GO:0042552 myelination; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044273 sulfur compound catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046395 carboxylic acid catabolic process; GO:0046466 membrane lipid catabolic process; GO:0046479 glycosphingolipid catabolic process; GO:0046514 ceramide catabolic process; GO:0046903 secretion; GO:0048468 cell development; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050654 chondroitin sulfate proteoglycan metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050884 neuromuscular process controlling posture; GO:0050885 neuromuscular process controlling balance; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0050954 sensory perception of mechanical stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051716 cellular response to stimulus; GO:0060395 SMAD protein signal transduction; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080171 lytic vacuole organization; GO:0090659 walking behavior; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1903509 liposaccharide metabolic process; GO:1903510 mucopolysaccharide metabolic process;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0042582 azurophil granule; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0003824 catalytic activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0004563 beta-N-acetylhexosaminidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008194 UDP-glycosyltransferase activity; GO:0008375 acetylglucosaminyltransferase activity; GO:0015929 hexosaminidase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity;","PF14845; PF00728","PF14845 beta-acetyl hexosaminidase like; PF00728 Glycosyl hydrolase family 20"," catalytic domain","G","KOG2499","Beta-N-acetylhexosaminidase","WP4153 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES;WP4815 GLYCOSAMINOGLYCAN DEGRADATION","http://www.wikipathways.org/instance/WP4153_r120394;http://www.wikipathways.org/instance/WP4815_r110276",null,"R-HSA-1430728 Metabolism;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-1638074 Keratan sulfate/keratin metabolism;R-HSA-1643685 Disease;R-HSA-1660662 Glycosphingolipid metabolism;R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism;R-HSA-2022857 Keratan sulfate degradation;R-HSA-2024101 CS/DS degradation;R-HSA-2142845 Hyaluronan metabolism;R-HSA-2160916 Hyaluronan uptake and degradation;R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism;R-HSA-3656234 Defective HEXA causes GM2G1;R-HSA-3781865 Diseases of glycosylation;R-HSA-428157 Sphingolipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-5668914 Diseases of metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-1638074;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1660662;https://reactome.org/PathwayBrowser/#/R-HSA-1793185;https://reactome.org/PathwayBrowser/#/R-HSA-2022857;https://reactome.org/PathwayBrowser/#/R-HSA-2024101;https://reactome.org/PathwayBrowser/#/R-HSA-2142845;https://reactome.org/PathwayBrowser/#/R-HSA-2160916;https://reactome.org/PathwayBrowser/#/R-HSA-3560782;https://reactome.org/PathwayBrowser/#/R-HSA-3656234;https://reactome.org/PathwayBrowser/#/R-HSA-3781865;https://reactome.org/PathwayBrowser/#/R-HSA-428157;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-71387","HYPOXIA","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA"]
["P07225","Vitamin K-dependent protein S OS=Homo sapiens OX=9606 GN=PROS1 PE=1 SV=1","PROS1",0.814868749,0.222968667,"nochange",2790.75,2985.61,3116.52,1821.77,2314.49,3110.27,1.037491457,1.109932767,1.158599974,0.677262676,0.860436658,1.156276469,"extracellular","K03908","PROS1; protein S","hsa04610 Complement and coagulation cascades","GO:0001889 liver development; GO:0002237 response to molecule of bacterial origin; GO:0002376 immune system process; GO:0002576 platelet degranulation; GO:0002673 regulation of acute inflammatory response; GO:0002682 regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002920 regulation of humoral immune response; GO:0006810 transport; GO:0006887 exocytosis; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009611 response to wounding; GO:0009617 response to bacterium; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010466 negative regulation of peptidase activity; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010951 negative regulation of endopeptidase activity; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0019222 regulation of metabolic process; GO:0030100 regulation of endocytosis; GO:0030162 regulation of proteolysis; GO:0030449 regulation of complement activation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031347 regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033993 response to lipid; GO:0040011 locomotion; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0043086 negative regulation of catalytic activity; GO:0043207 response to external biotic stimulus; GO:0044092 negative regulation of molecular function; GO:0045055 regulated exocytosis; GO:0045807 positive regulation of endocytosis; GO:0045861 negative regulation of proteolysis; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050727 regulation of inflammatory response; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050818 regulation of coagulation; GO:0050819 negative regulation of coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060627 regulation of vesicle-mediated transport; GO:0061008 hepaticobiliary system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070613 regulation of protein processing; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:1901700 response to oxygen-containing compound; GO:1903317 regulation of protein maturation; GO:2000257 regulation of protein activation cascade;","GO:0000139 Golgi membrane; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005796 Golgi lumen; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030141 secretory granule; GO:0031090 organelle membrane; GO:0031091 platelet alpha granule; GO:0031093 platelet alpha granule lumen; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098827 endoplasmic reticulum subcompartment; GO:0099503 secretory vesicle;","GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0005488 binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0044877 protein-containing complex binding; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0098772 molecular function regulator;","PF00594; PF00008; PF14670; PF07645; PF00054; PF02210","PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; PF00008 EGF-like domain; PF14670 Coagulation Factor Xa inhibitory site; PF07645 Calcium-binding EGF domain; PF00054 Laminin G domain; PF02210 Laminin G domain",{"$nulls":3},"WP558 COMPLEMENT AND COAGULATION CASCADES;WP2806 COMPLEMENT SYSTEM;WP5090 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY","http://www.wikipathways.org/instance/WP558_r119232;http://www.wikipathways.org/instance/WP2806_r116569;http://www.wikipathways.org/instance/WP5090_r118898",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation;R-HSA-140875 Common Pathway of Fibrin Clot Formation;R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade);R-HSA-159740 Gamma-carboxylation of protein precursors;R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus;R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins;R-HSA-159854 Gamma-carboxylation"," transport"," and amino-terminal cleavage of proteins;R-HSA-163841 Gamma carboxylation"," hypusine formation and arylsulfatase activation;R-HSA-166658 Complement cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-977606 Regulation of Complement cascade","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-140837;https://reactome.org/PathwayBrowser/#/R-HSA-140875;https://reactome.org/PathwayBrowser/#/R-HSA-140877;https://reactome.org/PathwayBrowser/#/R-HSA-159740;https://reactome.org/PathwayBrowser/#/R-HSA-159763;https://reactome.org/PathwayBrowser/#/R-HSA-159782;https://reactome.org/PathwayBrowser/#/R-HSA-159854;https://reactome.org/PathwayBrowser/#/R-HSA-163841;https://reactome.org/PathwayBrowser/#/R-HSA-166658;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-202733;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005;https://reactome.org/PathwayBrowser/#/R-HSA-977606","COAGULATION;XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COAGULATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["P07910","Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4","HNRNPC",1.464919273,{"v":2.86764e-05,"d":"2.87E-05"},"up",333655,337096,351648,491541,501573,504618,0.794375372,0.802567803,0.837213621,1.170274879,1.194159351,1.201408974,"nucleus","K12884","HNRNPC; heterogeneous nuclear ribonucleoprotein C1/C2","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032204 regulation of telomere maintenance; GO:0032205 negative regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032211 negative regulation of telomere maintenance via telomerase; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0043489 RNA stabilization; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048255 mRNA stabilization; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061013 regulation of mRNA catabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070935 3'-UTR-mediated mRNA stabilization; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090365 regulation of mRNA modification; GO:0090367 negative regulation of mRNA modification; GO:1901360 organic cyclic compound metabolic process; GO:1902369 negative regulation of RNA catabolic process; GO:1902373 negative regulation of mRNA catabolic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904357 negative regulation of telomere maintenance via telomere lengthening; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000279 negative regulation of DNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005697 telomerase holoenzyme complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0015629 actin cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045120 pronucleus; GO:0070013 intracellular organelle lumen; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990826 nucleoplasmic periphery of the nuclear pore complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008187 poly-pyrimidine tract binding; GO:0008266 poly(U) RNA binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0042802 identical protein binding; GO:0043021 ribonucleoprotein complex binding; GO:0044877 protein-containing complex binding; GO:0070034 telomerase RNA binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901363 heterocyclic compound binding; GO:1990247 N6-methyladenosine-containing RNA binding; GO:1990827 deaminase binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","R","KOG0118","FOG: RRM domain","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160","Transcription factor","R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-392499 Metabolism of proteins;R-HSA-4570464 SUMOylation of RNA binding proteins;R-HSA-597592 Post-translational protein modification;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013418 RHOBTB2 GTPase cycle;R-HSA-9013422 RHOBTB1 GTPase cycle;R-HSA-9706574 RHOBTB GTPase Cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4570464;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013418;https://reactome.org/PathwayBrowser/#/R-HSA-9013422;https://reactome.org/PathwayBrowser/#/R-HSA-9706574;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["P08069","Insulin-like growth factor 1 receptor OS=Homo sapiens OX=9606 GN=IGF1R PE=1 SV=1","IGF1R",1.172907111,0.076627377,"nochange",7390.66,6884.35,8489.93,9440.69,8651.53,8608.94,0.896451509,0.835038542,1.029787673,1.145110288,1.049388975,1.044223013,"extracellular","K05087","IGF1R; insulin-like growth factor 1 receptor [EC:2.7.10.1]","hsa04510 Focal adhesion; hsa04014 Ras signaling pathway; hsa05224 Breast cancer; hsa04913 Ovarian steroidogenesis; hsa01521 EGFR tyrosine kinase inhibitor resistance; hsa05200 Pathways in cancer; hsa05225 Hepatocellular carcinoma; hsa04211 Longevity regulating pathway; hsa05205 Proteoglycans in cancer; hsa04015 Rap1 signaling pathway; hsa04914 Progesterone-mediated oocyte maturation; hsa04213 Longevity regulating pathway - multiple species; hsa05214 Glioma; hsa01522 Endocrine resistance; hsa04152 AMPK signaling pathway; hsa04010 MAPK signaling pathway; hsa05215 Prostate cancer; hsa04150 mTOR signaling pathway; hsa04140 Autophagy - animal; hsa05202 Transcriptional misregulation in cancer; hsa04066 HIF-1 signaling pathway; hsa04550 Signaling pathways regulating pluripotency of stem cells; hsa04730 Long-term depression; hsa04520 Adherens junction; hsa04151 PI3K-Akt signaling pathway; hsa04068 FoxO signaling pathway; hsa05218 Melanoma; hsa04144 Endocytosis; hsa04114 Oocyte meiosis","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001101 response to acid chemical; GO:0001505 regulation of neurotransmitter levels; GO:0001655 urogenital system development; GO:0001678 cellular glucose homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002376 immune system process; GO:0003006 developmental process involved in reproduction; GO:0003007 heart morphogenesis; GO:0003008 system process; GO:0003205 cardiac chamber development; GO:0003230 cardiac atrium development; GO:0005979 regulation of glycogen biosynthetic process; GO:0006109 regulation of carbohydrate metabolic process; GO:0006110 regulation of glycolytic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006955 immune response; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0007530 sex determination; GO:0007568 aging; GO:0007569 cell aging; GO:0007584 response to nutrient; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007613 memory; GO:0007631 feeding behavior; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008286 insulin receptor signaling pathway; GO:0008340 determination of adult lifespan; GO:0008544 epidermis development; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009266 response to temperature stimulus; GO:0009268 response to pH; GO:0009314 response to radiation; GO:0009408 response to heat; GO:0009410 response to xenobiotic stimulus; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009791 post-embryonic development; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010286 heat acclimation; GO:0010446 response to alkaline pH; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010656 negative regulation of muscle cell apoptotic process; GO:0010660 regulation of muscle cell apoptotic process; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010676 positive regulation of cellular carbohydrate metabolic process; GO:0010720 positive regulation of cell development; GO:0010817 regulation of hormone levels; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010883 regulation of lipid storage; GO:0010888 negative regulation of lipid storage; GO:0010893 positive regulation of steroid biosynthetic process; GO:0010906 regulation of glucose metabolic process; GO:0010907 positive regulation of glucose metabolic process; GO:0010941 regulation of cell death; GO:0010962 regulation of glucan biosynthetic process; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014065 phosphatidylinositol 3-kinase signaling; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling; GO:0014070 response to organic cyclic compound; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016241 regulation of macroautophagy; GO:0016310 phosphorylation; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019048 modulation by virus of host process; GO:0019087 transformation of host cell by virus; GO:0019216 regulation of lipid metabolic process; GO:0019218 regulation of steroid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021549 cerebellum development; GO:0021761 limbic system development; GO:0021766 hippocampus development; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022611 dormancy process; GO:0022612 gland morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030238 male sex determination; GO:0030325 adrenal gland development; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030536 larval feeding behavior; GO:0030537 larval behavior; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030810 positive regulation of nucleotide biosynthetic process; GO:0030811 regulation of nucleotide catabolic process; GO:0030813 positive regulation of nucleotide catabolic process; GO:0030850 prostate gland development; GO:0030879 mammary gland development; GO:0030900 forebrain development; GO:0030902 hindbrain development; GO:0031016 pancreas development; GO:0031017 exocrine pancreas development; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031532 actin cytoskeleton reorganization; GO:0031667 response to nutrient levels; GO:0031960 response to corticosteroid; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032148 activation of protein kinase B activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032350 regulation of hormone metabolic process; GO:0032352 positive regulation of hormone metabolic process; GO:0032355 response to estradiol; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032465 regulation of cytokinesis; GO:0032467 positive regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032570 response to progesterone; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032881 regulation of polysaccharide metabolic process; GO:0032885 regulation of polysaccharide biosynthetic process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033197 response to vitamin E; GO:0033273 response to vitamin; GO:0033500 carbohydrate homeostasis; GO:0033554 cellular response to stress; GO:0033574 response to testosterone; GO:0033673 negative regulation of kinase activity; GO:0033674 positive regulation of kinase activity; GO:0033688 regulation of osteoblast proliferation; GO:0033690 positive regulation of osteoblast proliferation; GO:0033993 response to lipid; GO:0034284 response to monosaccharide; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0035094 response to nicotine; GO:0035270 endocrine system development; GO:0035272 exocrine system development; GO:0035556 intracellular signal transduction; GO:0035821 modulation of process of another organism; GO:0036211 protein modification process; GO:0038083 peptidyl-tyrosine autophosphorylation; GO:0040008 regulation of growth; GO:0040012 regulation of locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040015 negative regulation of multicellular organism growth; GO:0040017 positive regulation of locomotion; GO:0040018 positive regulation of multicellular organism growth; GO:0040024 dauer larval development; GO:0040034 regulation of development"," heterochronic; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042308 negative regulation of protein import into nucleus; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042594 response to starvation; GO:0042698 ovulation cycle; GO:0042981 regulation of apoptotic process; GO:0043054 dauer exit; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043200 response to amino acid; GO:0043243 positive regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043255 regulation of carbohydrate biosynthetic process; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043434 response to peptide hormone; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043470 regulation of carbohydrate catabolic process; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0043954 cellular component maintenance; GO:0044003 modulation by symbiont of host process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044088 regulation of vacuole organization; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044849 estrous cycle; GO:0045428 regulation of nitric oxide biosynthetic process; GO:0045429 positive regulation of nitric oxide biosynthetic process; GO:0045471 response to ethanol; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045725 positive regulation of glycogen biosynthetic process; GO:0045787 positive regulation of cell cycle; GO:0045821 positive regulation of glycolytic process; GO:0045834 positive regulation of lipid metabolic process; GO:0045840 positive regulation of mitotic nuclear division; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045887 positive regulation of synaptic assembly at neuromuscular junction; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045913 positive regulation of carbohydrate metabolic process; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045940 positive regulation of steroid metabolic process; GO:0045981 positive regulation of nucleotide metabolic process; GO:0045995 regulation of embryonic development; GO:0046324 regulation of glucose import; GO:0046326 positive regulation of glucose import; GO:0046328 regulation of JNK cascade; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0046677 response to antibiotic; GO:0046777 protein autophosphorylation; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046823 negative regulation of nucleocytoplasmic transport; GO:0046885 regulation of hormone biosynthetic process; GO:0046886 positive regulation of hormone biosynthetic process; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0048009 insulin-like growth factor receptor signaling pathway; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048468 cell development; GO:0048511 rhythmic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048580 regulation of post-embryonic development; GO:0048581 negative regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048679 regulation of axon regeneration; GO:0048680 positive regulation of axon regeneration; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050808 synapse organization; GO:0050810 regulation of steroid biosynthetic process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051262 protein tetramerization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051290 protein heterotetramerization; GO:0051291 protein heterooligomerization; GO:0051302 regulation of cell division; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051384 response to glucocorticoid; GO:0051385 response to mineralocorticoid; GO:0051445 regulation of meiotic cell cycle; GO:0051446 positive regulation of meiotic cell cycle; GO:0051701 biological process involved in interaction with host; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0051898 negative regulation of protein kinase B signaling; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0055082 cellular chemical homeostasis; GO:0055123 digestive system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060259 regulation of feeding behavior; GO:0060263 regulation of respiratory burst; GO:0060267 positive regulation of respiratory burst; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060512 prostate gland morphogenesis; GO:0060548 negative regulation of cell death; GO:0060740 prostate gland epithelium morphogenesis; GO:0061062 regulation of nematode larval development; GO:0061064 negative regulation of nematode larval development; GO:0061065 regulation of dauer larval development; GO:0061067 negative regulation of dauer larval development; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0062012 regulation of small molecule metabolic process; GO:0062013 positive regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070570 regulation of neuron projection regeneration; GO:0070572 positive regulation of neuron projection regeneration; GO:0070848 response to growth factor; GO:0070873 regulation of glycogen metabolic process; GO:0070875 positive regulation of glycogen metabolic process; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071326 cellular response to monosaccharide stimulus; GO:0071331 cellular response to hexose stimulus; GO:0071333 cellular response to glucose stimulus; GO:0071363 cellular response to growth factor stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071383 cellular response to steroid hormone stimulus; GO:0071384 cellular response to corticosteroid stimulus; GO:0071385 cellular response to glucocorticoid stimulus; GO:0071389 cellular response to mineralocorticoid stimulus; GO:0071392 cellular response to estradiol stimulus; GO:0071393 cellular response to progesterone stimulus; GO:0071394 cellular response to testosterone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071466 cellular response to xenobiotic stimulus; GO:0071467 cellular response to pH; GO:0071469 cellular response to alkaline pH; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071548 response to dexamethasone; GO:0071549 cellular response to dexamethasone stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0071981 exit from diapause; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090030 regulation of steroid hormone biosynthetic process; GO:0090031 positive regulation of steroid hormone biosynthetic process; GO:0090068 positive regulation of cell cycle process; GO:0090087 regulation of peptide transport; GO:0090317 negative regulation of intracellular protein transport; GO:0090398 cellular senescence; GO:0097061 dendritic spine organization; GO:0097062 dendritic spine maintenance; GO:0097242 amyloid-beta clearance; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097327 response to antineoplastic agent; GO:0099173 postsynapse organization; GO:0099177 regulation of trans-synaptic signaling; GO:0104004 cellular response to environmental stimulus; GO:0106027 neuron projection organization; GO:0110096 cellular response to aldehyde; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900073 regulation of neuromuscular synaptic transmission; GO:1900075 positive regulation of neuromuscular synaptic transmission; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1900180 regulation of protein localization to nucleus; GO:1900181 negative regulation of protein localization to nucleus; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900373 positive regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1900544 positive regulation of purine nucleotide metabolic process; GO:1901031 regulation of response to reactive oxygen species; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902065 response to L-glutamate; GO:1902074 response to salt; GO:1902075 cellular response to salt; GO:1902115 regulation of organelle assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902882 regulation of response to oxidative stress; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903426 regulation of reactive oxygen species biosynthetic process; GO:1903428 positive regulation of reactive oxygen species biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903578 regulation of ATP metabolic process; GO:1903580 positive regulation of ATP metabolic process; GO:1903828 negative regulation of protein localization; GO:1903943 regulation of hepatocyte apoptotic process; GO:1903944 negative regulation of hepatocyte apoptotic process; GO:1903998 regulation of eating behavior; GO:1904035 regulation of epithelial cell apoptotic process; GO:1904036 negative regulation of epithelial cell apoptotic process; GO:1904044 response to aldosterone; GO:1904045 cellular response to aldosterone; GO:1904192 regulation of cholangiocyte apoptotic process; GO:1904193 negative regulation of cholangiocyte apoptotic process; GO:1904385 cellular response to angiotensin; GO:1904396 regulation of neuromuscular junction development; GO:1904398 positive regulation of neuromuscular junction development; GO:1904407 positive regulation of nitric oxide metabolic process; GO:1904589 regulation of protein import; GO:1904590 negative regulation of protein import; GO:1904645 response to amyloid-beta; GO:1904646 cellular response to amyloid-beta; GO:1904950 negative regulation of establishment of protein localization; GO:1905909 regulation of dauer entry; GO:1905910 negative regulation of dauer entry; GO:1905952 regulation of lipid localization; GO:1905953 negative regulation of lipid localization; GO:1990314 cellular response to insulin-like growth factor stimulus; GO:1990535 neuron projection maintenance; GO:1990776 response to angiotensin; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process; GO:2000785 regulation of autophagosome assembly; GO:2001141 regulation of RNA biosynthetic process; GO:2001169 regulation of ATP biosynthetic process; GO:2001171 positive regulation of ATP biosynthetic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005899 insulin receptor complex; GO:0005901 caveola; GO:0005929 cilium; GO:0009897 external side of plasma membrane; GO:0009986 cell surface; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030315 T-tubule; GO:0030424 axon; GO:0030425 dendrite; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032589 neuron projection membrane; GO:0032590 dendrite membrane; GO:0032809 neuronal cell body membrane; GO:0032991 protein-containing complex; GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex; GO:0036477 somatodendritic compartment; GO:0042383 sarcolemma; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043235 receptor complex; GO:0044214 spanning component of plasma membrane; GO:0044297 cell body; GO:0044298 cell body membrane; GO:0044853 plasma membrane raft; GO:0045121 membrane raft; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0071944 cell periphery; GO:0089717 spanning component of membrane; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0097730 non-motile cilium; GO:0098552 side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex; GO:0098857 membrane microdomain; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0000166 nucleotide binding; GO:0001540 amyloid-beta binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0001965 G-protein alpha-subunit binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004714 transmembrane receptor protein tyrosine kinase activity; GO:0004888 transmembrane signaling receptor activity; GO:0005009 insulin-activated receptor activity; GO:0005010 insulin-like growth factor-activated receptor activity; GO:0005102 signaling receptor binding; GO:0005158 insulin receptor binding; GO:0005159 insulin-like growth factor receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005520 insulin-like growth factor binding; GO:0005524 ATP binding; GO:0005525 GTP binding; GO:0016301 kinase activity; GO:0016500 protein-hormone receptor activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017046 peptide hormone binding; GO:0017076 purine nucleotide binding; GO:0019001 guanyl nucleotide binding; GO:0019199 transmembrane receptor protein kinase activity; GO:0019838 growth factor binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030554 adenyl nucleotide binding; GO:0031994 insulin-like growth factor I binding; GO:0031995 insulin-like growth factor II binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0033218 amide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0038023 signaling receptor activity; GO:0042169 SH2 domain binding; GO:0042277 peptide binding; GO:0042562 hormone binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043548 phosphatidylinositol 3-kinase binding; GO:0043559 insulin binding; GO:0043560 insulin receptor substrate binding; GO:0044877 protein-containing complex binding; GO:0051425 PTB domain binding; GO:0060089 molecular transducer activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00757; PF07714","PF00757 Furin-like cysteine rich region; PF07714 Protein tyrosine and serine/threonine kinase","T","KOG4258","Insulin/growth factor receptor (contains protein kinase domain)","WP254 APOPTOSIS;WP4262 BREAST CANCER PATHWAY;WP4217 EBOLA VIRUS INFECTION IN HOST;WP4806 EGFR TYROSINE KINASE INHIBITOR RESISTANCE;WP474 ENDOCHONDRAL OSSIFICATION;WP4808 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS;WP3850 FACTORS AND PATHWAYS AFFECTING INSULINLIKE GROWTH FACTOR IGF1AKT SIGNALING;WP306 FOCAL ADHESION;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP2261 GLIOBLASTOMA SIGNALING PATHWAYS;WP4674 HEAD AND NECK SQUAMOUS CELL CARCINOMA;WP4540 HIPPO SIGNALING REGULATION PATHWAYS;WP4541 HIPPOMERLIN SIGNALING DYSREGULATION;WP481 INSULIN SIGNALING;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP3584 MECP2 AND ASSOCIATED RETT SYNDROME;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP4172 PI3KAKT SIGNALING PATHWAY;WP4223 RAS SIGNALING;WP4186 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING;WP2032 THYROID STIMULATING HORMONE TSH SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP254_r118382;http://www.wikipathways.org/instance/WP4262_r108103;http://www.wikipathways.org/instance/WP4217_r120623;http://www.wikipathways.org/instance/WP4806_r116801;http://www.wikipathways.org/instance/WP474_r117098;http://www.wikipathways.org/instance/WP4808_r117708;http://www.wikipathways.org/instance/WP3850_r110688;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP2261_r118379;http://www.wikipathways.org/instance/WP4674_r117748;http://www.wikipathways.org/instance/WP4540_r120395;http://www.wikipathways.org/instance/WP4541_r116745;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP3584_r117155;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP4223_r119284;http://www.wikipathways.org/instance/WP4186_r105819;http://www.wikipathways.org/instance/WP2032_r120723","Transcription factor","R-HSA-162582 Signal Transduction;R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);R-HSA-2428924 IGF1R signaling cascade;R-HSA-2428928 IRS-related events triggered by IGF1R;R-HSA-2428933 SHC-related events triggered by IGF1R;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9009391 Extra-nuclear estrogen signaling","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-2404192;https://reactome.org/PathwayBrowser/#/R-HSA-2428924;https://reactome.org/PathwayBrowser/#/R-HSA-2428928;https://reactome.org/PathwayBrowser/#/R-HSA-2428933;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9009391","ESTROGEN RESPONSE EARLY;IL2 STAT5 SIGNALING;UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["P08567","Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3","PLEK",1.412064361,0.00056345,"up",73131.1,73847,81166.6,106568,106126,109461,0.79735933,0.805164895,0.884971589,1.161926855,1.157107663,1.193469668,"cytoplasm","K19993",null,null,"GO:0001775 cell activation; GO:0002244 hematopoietic progenitor cell differentiation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002576 platelet degranulation; GO:0002790 peptide secretion; GO:0006109 regulation of carbohydrate metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006904 vesicle docking involved in exocytosis; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007275 multicellular organism development; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008361 regulation of cell size; GO:0009306 protein secretion; GO:0009611 response to wounding; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010543 regulation of platelet activation; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010572 positive regulation of platelet activation; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010677 negative regulation of cellular carbohydrate metabolic process; GO:0010919 regulation of inositol phosphate biosynthetic process; GO:0010920 negative regulation of inositol phosphate biosynthetic process; GO:0010921 regulation of phosphatase activity; GO:0010922 positive regulation of phosphatase activity; GO:0010924 regulation of inositol-polyphosphate 5-phosphatase activity; GO:0010925 positive regulation of inositol-polyphosphate 5-phosphatase activity; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0022406 membrane docking; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0030168 platelet activation; GO:0030193 regulation of blood coagulation; GO:0030194 positive regulation of blood coagulation; GO:0030832 regulation of actin filament length; GO:0030834 regulation of actin filament depolymerization; GO:0030836 positive regulation of actin filament depolymerization; GO:0030845 phospholipase C-inhibiting G protein-coupled receptor signaling pathway; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031529 ruffle organization; GO:0031532 actin cytoskeleton reorganization; GO:0032101 regulation of response to external stimulus; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033623 regulation of integrin activation; GO:0033625 positive regulation of integrin activation; GO:0034109 homotypic cell-cell adhesion; GO:0035303 regulation of dephosphorylation; GO:0035306 positive regulation of dephosphorylation; GO:0035556 intracellular signal transduction; GO:0042060 wound healing; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043243 positive regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043255 regulation of carbohydrate biosynthetic process; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0045744 negative regulation of G protein-coupled receptor signaling pathway; GO:0045912 negative regulation of carbohydrate metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046903 secretion; GO:0048278 vesicle docking; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050818 regulation of coagulation; GO:0050820 positive regulation of coagulation; GO:0050848 regulation of calcium-mediated signaling; GO:0050849 negative regulation of calcium-mediated signaling; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060305 regulation of cell diameter; GO:0061041 regulation of wound healing; GO:0062012 regulation of small molecule metabolic process; GO:0062014 negative regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070493 thrombin-activated receptor signaling pathway; GO:0070527 platelet aggregation; GO:0070528 protein kinase C signaling; GO:0070560 protein secretion by platelet; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090066 regulation of anatomical structure size; GO:0090303 positive regulation of wound healing; GO:0098609 cell-cell adhesion; GO:0110053 regulation of actin filament organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering; GO:1900046 regulation of hemostasis; GO:1900048 positive regulation of hemostasis; GO:1901879 regulation of protein depolymerization; GO:1901881 positive regulation of protein depolymerization; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1902930 regulation of alcohol biosynthetic process; GO:1902931 negative regulation of alcohol biosynthetic process; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0001726 ruffle; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0032587 ruffle membrane; GO:0042995 cell projection; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0120025 plasma membrane bounded cell projection;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0005080 protein kinase C binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0035091 phosphatidylinositol binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043325 phosphatidylinositol-3","4-bisphosphate binding; GO:0046983 protein dimerization activity; GO:0140110 transcription regulator activity; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00169; PF00610","PF00169 PH domain; PF00610 Domain found in Dishevelled"," Egl-10"," and Pleckstrin (DEP)",{"$nulls":3},"WP3947 SEROTONIN AND ANXIETY;WP3944 SEROTONIN AND ANXIETYRELATED EVENTS;WP3945 TYROBP CAUSAL NETWORK IN MICROGLIA","http://www.wikipathways.org/instance/WP3947_r106483;http://www.wikipathways.org/instance/WP3944_r120596;http://www.wikipathways.org/instance/WP3945_r116679",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005","COAGULATION;COMPLEMENT;TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COAGULATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["P08910","Monoacylglycerol lipase ABHD2 OS=Homo sapiens OX=9606 GN=ABHD2 PE=1 SV=1","ABHD2",1.437961323,0.527288321,"nochange",2107.16,1749.46,2174.94,3676.69,3745.28,1251.18,0.859789822,0.713836587,0.887446267,1.500209117,1.528196068,0.510522139,"extracellular","K13697",null,null,"GO:0000003 reproduction; GO:0003006 developmental process involved in reproduction; GO:0006629 lipid metabolic process; GO:0006638 neutral lipid metabolic process; GO:0006639 acylglycerol metabolic process; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007338 single fertilization; GO:0007340 acrosome reaction; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009566 fertilization; GO:0009611 response to wounding; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0014070 response to organic cyclic compound; GO:0016042 lipid catabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032570 response to progesterone; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0033993 response to lipid; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042221 response to chemical; GO:0043401 steroid hormone mediated signaling pathway; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044703 multi-organism reproductive process; GO:0046461 neutral lipid catabolic process; GO:0046464 acylglycerol catabolic process; GO:0046486 glycerolipid metabolic process; GO:0046503 glycerolipid catabolic process; GO:0048232 male gamete generation; GO:0048240 sperm capacitation; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048515 spermatid differentiation; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:1901575 organic substance catabolic process; GO:1901654 response to ketone; GO:1901700 response to oxygen-containing compound; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility;","GO:0001669 acrosomal vesicle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031514 motile cilium; GO:0031982 vesicle; GO:0036126 sperm flagellum; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0071944 cell periphery; GO:0097524 sperm plasma membrane; GO:0097708 intracellular vesicle; GO:0097729 9+2 motile cilium; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0003707 steroid hormone receptor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0016298 lipase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0038023 signaling receptor activity; GO:0042562 hormone binding; GO:0047372 acylglycerol lipase activity; GO:0052689 carboxylic ester hydrolase activity; GO:0060089 molecular transducer activity;","PF00561","PF00561 alpha/beta hydrolase fold","R","KOG1838","Alpha/beta hydrolase","WP2880 GLUCOCORTICOID RECEPTOR PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY","http://www.wikipathways.org/instance/WP2880_r117734;http://www.wikipathways.org/instance/WP2882_r117808",{"$nulls":3},"ANDROGEN RESPONSE;ESTROGEN RESPONSE EARLY;ESTROGEN RESPONSE LATE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE"]
["P09211","Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2","GSTP1",1.239683861,{"v":3.38203e-05,"d":"3.38E-05"},"up",245622,242208,242482,303684,305500,296172,0.900997024,0.8884737,0.889478794,1.113981566,1.120643064,1.086425852,"mitochondria","K23790","GSTP; glutathione S-transferase P [EC:2.5.1.18]","hsa05204 Chemical carcinogenesis - DNA adducts; hsa05215 Prostate cancer; hsa00480 Glutathione metabolism; hsa00982 Drug metabolism - cytochrome P450; hsa05200 Pathways in cancer; hsa05418 Fluid shear stress and atherosclerosis; hsa05225 Hepatocellular carcinoma; hsa00983 Drug metabolism - other enzymes; hsa01524 Platinum drug resistance; hsa00980 Metabolism of xenobiotics by cytochrome P450; hsa01100 Metabolic pathways","GO:0000302 response to reactive oxygen species; GO:0001101 response to acid chemical; GO:0001676 long-chain fatty acid metabolic process; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001960 negative regulation of cytokine-mediated signaling pathway; GO:0002237 response to molecule of bacterial origin; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002673 regulation of acute inflammatory response; GO:0002674 negative regulation of acute inflammatory response; GO:0006082 organic acid metabolic process; GO:0006469 negative regulation of protein kinase activity; GO:0006518 peptide metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006749 glutathione metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006979 response to oxidative stress; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007584 response to nutrient; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010001 glial cell differentiation; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014003 oligodendrocyte development; GO:0014070 response to organic cyclic compound; GO:0014910 regulation of smooth muscle cell migration; GO:0014912 negative regulation of smooth muscle cell migration; GO:0016192 vesicle-mediated transport; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0021782 glial cell development; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0031099 regeneration; GO:0031100 animal organ regeneration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031960 response to corticosteroid; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032355 response to estradiol; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032642 regulation of chemokine production; GO:0032651 regulation of interleukin-1 beta production; GO:0032652 regulation of interleukin-1 production; GO:0032680 regulation of tumor necrosis factor production; GO:0032682 negative regulation of chemokine production; GO:0032691 negative regulation of interleukin-1 beta production; GO:0032692 negative regulation of interleukin-1 production; GO:0032720 negative regulation of tumor necrosis factor production; GO:0032787 monocarboxylic acid metabolic process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032928 regulation of superoxide anion generation; GO:0032930 positive regulation of superoxide anion generation; GO:0032940 secretion by cell; GO:0033273 response to vitamin; GO:0033483 gas homeostasis; GO:0033484 nitric oxide homeostasis; GO:0033559 unsaturated fatty acid metabolic process; GO:0033591 response to L-ascorbic acid; GO:0033673 negative regulation of kinase activity; GO:0033993 response to lipid; GO:0034284 response to monosaccharide; GO:0034641 cellular nitrogen compound metabolic process; GO:0035726 common myeloid progenitor cell proliferation; GO:0035732 nitric oxide storage; GO:0036230 granulocyte activation; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042063 gliogenesis; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043200 response to amino acid; GO:0043207 response to external biotic stimulus; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0043506 regulation of JUN kinase activity; GO:0043508 negative regulation of JUN kinase activity; GO:0043549 regulation of kinase activity; GO:0043603 cellular amide metabolic process; GO:0043651 linoleic acid metabolic process; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045055 regulated exocytosis; GO:0045087 innate immune response; GO:0045321 leukocyte activation; GO:0045471 response to ethanol; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046677 response to antibiotic; GO:0046903 secretion; GO:0048145 regulation of fibroblast proliferation; GO:0048147 negative regulation of fibroblast proliferation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048662 negative regulation of smooth muscle cell proliferation; GO:0048709 oligodendrocyte differentiation; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050727 regulation of inflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050829 defense response to Gram-negative bacterium; GO:0050896 response to stimulus; GO:0050920 regulation of chemotaxis; GO:0050922 negative regulation of chemotaxis; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051341 regulation of oxidoreductase activity; GO:0051348 negative regulation of transferase activity; GO:0051354 negative regulation of oxidoreductase activity; GO:0051384 response to glucocorticoid; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051769 regulation of nitric-oxide synthase biosynthetic process; GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060759 regulation of response to cytokine stimulus; GO:0060761 negative regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070373 negative regulation of ERK1 and ERK2 cascade; GO:0070663 regulation of leukocyte proliferation; GO:0070664 negative regulation of leukocyte proliferation; GO:0070848 response to growth factor; GO:0070849 response to epidermal growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071364 cellular response to epidermal growth factor stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071383 cellular response to steroid hormone stimulus; GO:0071384 cellular response to corticosteroid stimulus; GO:0071385 cellular response to glucocorticoid stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071460 cellular response to cell-matrix adhesion; GO:0071466 cellular response to xenobiotic stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071637 regulation of monocyte chemotactic protein-1 production; GO:0071638 negative regulation of monocyte chemotactic protein-1 production; GO:0071671 regulation of smooth muscle cell chemotaxis; GO:0071672 negative regulation of smooth muscle cell chemotaxis; GO:0071704 organic substance metabolic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090322 regulation of superoxide metabolic process; GO:0097237 cellular response to toxic substance; GO:0097305 response to alcohol; GO:0098542 defense response to other organism; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901685 glutathione derivative metabolic process; GO:1901687 glutathione derivative biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903038 negative regulation of leukocyte cell-cell adhesion; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production; GO:1904705 regulation of vascular associated smooth muscle cell proliferation; GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation; GO:1905802 regulation of cellular response to manganese ion; GO:1905803 negative regulation of cellular response to manganese ion; GO:1905804 positive regulation of cellular response to manganese ion; GO:1990748 cellular detoxification; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process; GO:2000428 regulation of neutrophil aggregation; GO:2000429 negative regulation of neutrophil aggregation; GO:2000468 regulation of peroxidase activity; GO:2000469 negative regulation of peroxidase activity; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001237 negative regulation of extrinsic apoptotic signaling pathway;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097057 TRAF2-GSTP1 complex; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen;","GO:0003824 catalytic activity; GO:0004364 glutathione transferase activity; GO:0004601 peroxidase activity; GO:0004602 glutathione peroxidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008432 JUN kinase binding; GO:0016209 antioxidant activity; GO:0016491 oxidoreductase activity; GO:0016684 oxidoreductase activity"," acting on peroxide as acceptor; GO:0016740 transferase activity; GO:0016765 transferase activity"," transferring alkyl or aryl (other than methyl) groups; GO:0019207 kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0033218 amide binding; GO:0035730 S-nitrosoglutathione binding; GO:0035731 dinitrosyl-iron complex binding; GO:0042277 peptide binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043295 glutathione binding; GO:0070026 nitric oxide binding; GO:0072341 modified amino acid binding; GO:0098772 molecular function regulator; GO:1900750 oligopeptide binding; GO:1901681 sulfur compound binding;","PF02798; PF14497","PF02798 Glutathione S-transferase"," N-terminal domain; PF14497 Glutathione S-transferase"," C-terminal domain","O","KOG1695","Glutathione S-transferase","WP678 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE;WP410 EXERCISEINDUCED CIRCADIAN REGULATION;WP702 METAPATHWAY BIOTRANSFORMATION PHASE I AND II;WP2884 NRF2 PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP3612 PHOTODYNAMIC THERAPYINDUCED NFE2L2 NRF2 SURVIVAL SIGNALING","http://www.wikipathways.org/instance/WP678_r116938;http://www.wikipathways.org/instance/WP410_r117108;http://www.wikipathways.org/instance/WP702_r106643;http://www.wikipathways.org/instance/WP2884_r106658;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP3612_r106540",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-211859 Biological oxidations;R-HSA-2262752 Cellular responses to stress;R-HSA-3299685 Detoxification of Reactive Oxygen Species;R-HSA-6798695 Neutrophil degranulation;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9748784 Drug ADME;R-HSA-9753281 Paracetamol ADME","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3299685;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9711123;https://reactome.org/PathwayBrowser/#/R-HSA-9748784;https://reactome.org/PathwayBrowser/#/R-HSA-9753281"]
["P09493","Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2","TPM1",1.412569927,0.014359136,"nochange",32048.8,37691.5,37603.2,55760.7,44815.6,51053.9,0.742518642,0.873250836,0.871205068,1.291884852,1.038304662,1.18283594,"cytoplasm","K10373","TPM1; tropomyosin 1","hsa04260 Cardiac muscle contraction; hsa05410 Hypertrophic cardiomyopathy; hsa05206 MicroRNAs in cancer; hsa05414 Dilated cardiomyopathy; hsa04261 Adrenergic signaling in cardiomyocytes","GO:0000302 response to reactive oxygen species; GO:0001701 in utero embryonic development; GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine; GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine; GO:0002027 regulation of heart rate; GO:0003007 heart morphogenesis; GO:0003008 system process; GO:0003012 muscle system process; GO:0003013 circulatory system process; GO:0003015 heart process; GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal; GO:0003062 regulation of heart rate by chemical signal; GO:0003065 positive regulation of heart rate by epinephrine; GO:0003073 regulation of systemic arterial blood pressure; GO:0003205 cardiac chamber development; GO:0003206 cardiac chamber morphogenesis; GO:0003208 cardiac ventricle morphogenesis; GO:0003229 ventricular cardiac muscle tissue development; GO:0003231 cardiac ventricle development; GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine; GO:0006928 movement of cell or subcellular component; GO:0006936 muscle contraction; GO:0006937 regulation of muscle contraction; GO:0006941 striated muscle contraction; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007275 multicellular organism development; GO:0007507 heart development; GO:0007517 muscle organ development; GO:0008015 blood circulation; GO:0008016 regulation of heart contraction; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008217 regulation of blood pressure; GO:0008285 negative regulation of cell population proliferation; GO:0008360 regulation of cell shape; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010460 positive regulation of heart rate; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010927 cellular component assembly involved in morphogenesis; GO:0014706 striated muscle tissue development; GO:0014910 regulation of smooth muscle cell migration; GO:0014912 negative regulation of smooth muscle cell migration; GO:0016043 cellular component organization; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030048 actin filament-based movement; GO:0030049 muscle filament sliding; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030239 myofibril assembly; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030834 regulation of actin filament depolymerization; GO:0030835 negative regulation of actin filament depolymerization; GO:0030837 negative regulation of actin filament polymerization; GO:0031032 actomyosin structure organization; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031529 ruffle organization; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032781 positive regulation of ATP-dependent activity; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0033275 actin-myosin filament sliding; GO:0033554 cellular response to stress; GO:0034599 cellular response to oxidative stress; GO:0034614 cellular response to reactive oxygen species; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042692 muscle cell differentiation; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043242 negative regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043462 regulation of ATP-dependent activity; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045214 sarcomere organization; GO:0045777 positive regulation of blood pressure; GO:0045785 positive regulation of cell adhesion; GO:0045823 positive regulation of heart contraction; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048644 muscle organ morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048662 negative regulation of smooth muscle cell proliferation; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051496 positive regulation of stress fiber assembly; GO:0051693 actin filament capping; GO:0051716 cellular response to stimulus; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0055008 cardiac muscle tissue morphogenesis; GO:0055010 ventricular cardiac muscle tissue morphogenesis; GO:0060047 heart contraction; GO:0060048 cardiac muscle contraction; GO:0060415 muscle tissue morphogenesis; GO:0060537 muscle tissue development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070252 actin-mediated cell contraction; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0090066 regulation of anatomical structure size; GO:0090257 regulation of muscle system process; GO:0097435 supramolecular fiber organization; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901879 regulation of protein depolymerization; GO:1901880 negative regulation of protein depolymerization; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903522 regulation of blood circulation; GO:1903524 positive regulation of blood circulation; GO:1904705 regulation of vascular associated smooth muscle cell proliferation; GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation; GO:1904752 regulation of vascular associated smooth muscle cell migration; GO:1904753 negative regulation of vascular associated smooth muscle cell migration; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility;","GO:0001725 stress fiber; GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005862 muscle thin filament tropomyosin; GO:0005865 striated muscle thin filament; GO:0005884 actin filament; GO:0005886 plasma membrane; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0032059 bleb; GO:0032432 actin filament bundle; GO:0032587 ruffle membrane; GO:0032991 protein-containing complex; GO:0036379 myofilament; GO:0042641 actomyosin; GO:0042995 cell projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0071944 cell periphery; GO:0097517 contractile actin filament bundle; GO:0098590 plasma membrane region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008307 structural constituent of muscle; GO:0019904 protein domain specific binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0047485 protein N-terminus binding; GO:0051015 actin filament binding; GO:0097718 disordered domain specific binding;",null,null,"Z","KOG1003","Actin filament-coating protein tropomyosin","WP383 STRIATED MUSCLE CONTRACTION PATHWAY;WP2877 VITAMIN D RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP383_r118423;http://www.wikipathways.org/instance/WP2877_r119905",null,"R-HSA-390522 Striated Muscle Contraction;R-HSA-397014 Muscle contraction;R-HSA-445355 Smooth Muscle Contraction","https://reactome.org/PathwayBrowser/#/R-HSA-390522;https://reactome.org/PathwayBrowser/#/R-HSA-397014;https://reactome.org/PathwayBrowser/#/R-HSA-445355","EPITHELIAL MESENCHYMAL TRANSITION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"]
["P0C0L4","Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2","C4A",1.389906622,0.062341344,"nochange",4387.93,3026.8,3866.33,5029.27,5971.87,4678.48,0.976517655,0.673603188,0.860437496,1.119245509,1.329017666,1.041178487,"extracellular","K03989","C4; complement component 4","hsa05322 Systemic lupus erythematosus; hsa04936 Alcoholic liver disease; hsa05133 Pertussis; hsa04610 Complement and coagulation cascades; hsa05150 Staphylococcus aureus infection; hsa05171 Coronavirus disease - COVID-19","GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002237 response to molecule of bacterial origin; GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002673 regulation of acute inflammatory response; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002685 regulation of leukocyte migration; GO:0002686 negative regulation of leukocyte migration; GO:0002688 regulation of leukocyte chemotaxis; GO:0002689 negative regulation of leukocyte chemotaxis; GO:0002697 regulation of immune effector process; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0002920 regulation of humoral immune response; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006911 phagocytosis"," engulfment; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006956 complement activation; GO:0006957 complement activation"," alternative pathway; GO:0006959 humoral immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0008152 metabolic process; GO:0008228 opsonization; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0009593 detection of chemical stimulus; GO:0009595 detection of biotic stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010324 membrane invagination; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010574 regulation of vascular endothelial growth factor production; GO:0010575 positive regulation of vascular endothelial growth factor production; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010758 regulation of macrophage chemotaxis; GO:0010760 negative regulation of macrophage chemotaxis; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010866 regulation of triglyceride biosynthetic process; GO:0010883 regulation of lipid storage; GO:0010884 positive regulation of lipid storage; GO:0016043 cellular component organization; GO:0016064 immunoglobulin mediated immune response; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019724 B cell mediated immunity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030100 regulation of endocytosis; GO:0030162 regulation of proteolysis; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030449 regulation of complement activation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032490 detection of molecule of bacterial origin; GO:0032501 multicellular organismal process; GO:0032642 regulation of chemokine production; GO:0032722 positive regulation of chemokine production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0033674 positive regulation of kinase activity; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043687 post-translational protein modification; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045087 innate immune response; GO:0045321 leukocyte activation; GO:0045745 positive regulation of G protein-coupled receptor signaling pathway; GO:0045807 positive regulation of endocytosis; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046890 regulation of lipid biosynthetic process; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048870 cell motility; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050727 regulation of inflammatory response; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0050920 regulation of chemotaxis; GO:0050922 negative regulation of chemotaxis; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051606 detection of stimulus; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060326 cell chemotaxis; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070613 regulation of protein processing; GO:0070887 cellular response to chemical stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072376 protein activation cascade; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:0090207 regulation of triglyceride metabolic process; GO:0097242 amyloid-beta clearance; GO:0098581 detection of external biotic stimulus; GO:0098657 import into cell; GO:0099024 plasma membrane invagination; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903317 regulation of protein maturation; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904951 positive regulation of establishment of protein localization; GO:1905521 regulation of macrophage migration; GO:1905522 negative regulation of macrophage migration; GO:1905952 regulation of lipid localization; GO:1905954 positive regulation of lipid localization; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000257 regulation of protein activation cascade; GO:2000425 regulation of apoptotic cell clearance; GO:2000427 positive regulation of apoptotic cell clearance;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005579 membrane attack complex; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030424 axon; GO:0030425 dendrite; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0036477 somatodendritic compartment; GO:0042582 azurophil granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044217 other organism part; GO:0044297 cell body; GO:0045202 synapse; GO:0046930 pore complex; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0001664 G protein-coupled receptor binding; GO:0001846 opsonin binding; GO:0001848 complement binding; GO:0001849 complement component C1q complex binding; GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004252 serine-type endopeptidase activity; GO:0005102 signaling receptor binding; GO:0005125 cytokine activity; GO:0005126 cytokine receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008009 chemokine activity; GO:0008233 peptidase activity; GO:0008236 serine-type peptidase activity; GO:0016787 hydrolase activity; GO:0017171 serine hydrolase activity; GO:0030246 carbohydrate binding; GO:0030545 signaling receptor regulator activity; GO:0031714 C5a anaphylatoxin chemotactic receptor binding; GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding; GO:0042379 chemokine receptor binding; GO:0048018 receptor ligand activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF01835; PF17791; PF17789; PF07703; PF01821; PF07677; PF01759","PF01835 MG2 domain; PF17791 Macroglobulin domain MG3; PF17789 Macroglobulin domain MG4; PF07703 Alpha-2-macroglobulin bait region domain; PF01821 Anaphylotoxin-like domain; PF07677 A-macroglobulin receptor binding domain; PF01759 UNC-6/NTR/C345C module","O","KOG1366","Alpha-macroglobulin","WP2328 ALLOGRAFT REJECTION;WP545 COMPLEMENT ACTIVATION;WP558 COMPLEMENT AND COAGULATION CASCADES;WP2806 COMPLEMENT SYSTEM;WP5090 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY;WP3941 OXIDATIVE DAMAGE RESPONSE;WP706 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS","http://www.wikipathways.org/instance/WP2328_r120776;http://www.wikipathways.org/instance/WP545_r116815;http://www.wikipathways.org/instance/WP558_r119232;http://www.wikipathways.org/instance/WP2806_r116569;http://www.wikipathways.org/instance/WP5090_r118898;http://www.wikipathways.org/instance/WP3941_r117040;http://www.wikipathways.org/instance/WP706_r117178",null,"R-HSA-166658 Complement cascade;R-HSA-166663 Initial triggering of complement;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-174577 Activation of C3 and C5;R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs);R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8957275 Post-translational protein phosphorylation;R-HSA-977606 Regulation of Complement cascade","https://reactome.org/PathwayBrowser/#/R-HSA-166658;https://reactome.org/PathwayBrowser/#/R-HSA-166663;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-174577;https://reactome.org/PathwayBrowser/#/R-HSA-381426;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8957275;https://reactome.org/PathwayBrowser/#/R-HSA-977606"]
["P10176","Cytochrome c oxidase subunit 8A"," mitochondrial OS=Homo sapiens OX=9606 GN=COX8A PE=1 SV=2","COX8A",1.312901361,0.23156057,"nochange",5534.47,6411.5,10354.7,10219.7,7993.88,11065,0.643801916,0.745823175,1.204519259,1.18881527,0.929894871,1.287145509,"mitochondria","K02273","COX8; cytochrome c oxidase subunit 8","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04260 Cardiac muscle contraction; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006123 mitochondrial electron transport"," cytochrome c to oxygen; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0008152 metabolic process; GO:0009060 aerobic respiration; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0019646 aerobic electron transport chain; GO:0019693 ribose phosphate metabolic process; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0034220 ion transmembrane transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902600 proton transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005751 mitochondrial respiratory chain complex IV; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045277 respiratory chain complex IV; GO:0070069 cytochrome complex; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex;","GO:0003824 catalytic activity; GO:0004129 cytochrome-c oxidase activity; GO:0005215 transporter activity; GO:0008324 cation transmembrane transporter activity; GO:0009055 electron transfer activity; GO:0015075 ion transmembrane transporter activity; GO:0015078 proton transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0016491 oxidoreductase activity; GO:0016675 oxidoreductase activity"," acting on a heme group of donors; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity;",{"$nulls":5},"WP678 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE;WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4922 MITOCHONDRIAL COMPLEX IV ASSEMBLY;WP4396 NONALCOHOLIC FATTY LIVER DISEASE","http://www.wikipathways.org/instance/WP678_r116938;http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4922_r117792;http://www.wikipathways.org/instance/WP4396_r98945",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5628897 TP53 Regulates Metabolic Genes;R-HSA-611105 Respiratory electron transport;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953897 Cellular responses to stimuli;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5628897;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9711123","ADIPOGENESIS;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P10721","Mast/stem cell growth factor receptor Kit OS=Homo sapiens OX=9606 GN=KIT PE=1 SV=1","KIT",3.526309377,{"v":8.06413E-6,"d":"8.06E-06"},"up",22931.4,20662.3,23709.3,79165.8,80683.5,77481.9,0.451651193,0.40695956,0.46697252,1.559230054,1.589122298,1.526064375,"endoplasmic reticulum","K05091","KIT; proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]","hsa04014 Ras signaling pathway; hsa05224 Breast cancer; hsa04072 Phospholipase D signaling pathway; hsa05221 Acute myeloid leukemia; hsa05200 Pathways in cancer; hsa04916 Melanogenesis; hsa04151 PI3K-Akt signaling pathway; hsa04015 Rap1 signaling pathway; hsa04640 Hematopoietic cell lineage; hsa05230 Central carbon metabolism in cancer; hsa04010 MAPK signaling pathway","GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0001501 skeletal system development; GO:0001541 ovarian follicle development; GO:0001667 ameboidal-type cell migration; GO:0001775 cell activation; GO:0001816 cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002244 hematopoietic progenitor cell differentiation; GO:0002252 immune effector process; GO:0002262 myeloid cell homeostasis; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002279 mast cell activation involved in immune response; GO:0002318 myeloid progenitor cell differentiation; GO:0002320 lymphoid progenitor cell differentiation; GO:0002327 immature B cell differentiation; GO:0002366 leukocyte activation involved in immune response; GO:0002367 cytokine production involved in immune response; GO:0002371 dendritic cell cytokine production; GO:0002376 immune system process; GO:0002440 production of molecular mediator of immune response; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002448 mast cell mediated immunity; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002551 mast cell chemotaxis; GO:0002573 myeloid leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003012 muscle system process; GO:0006355 regulation of transcription",{"$cut":{"chars":19389,"head":" DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006664 glycolipid metabolic process; GO:0006665 sphingolipid metabolic process; GO:0006687 glycosphingolipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006936 muscle contraction; GO:0006937 regulation of muscle contraction; GO:0006939 smooth muscle contraction; GO:0006940 regulation of smooth muscle contraction; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007399 nervous system development; GO:0007548 sex differentiation; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007632 visual behavior; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008306 associative learning; GO:0008354 germ cell migration; GO:0008360 regulation of cell shape; GO:0008406 gonad development; GO:0008542 visual learning; GO:0008584 male gonad development; GO:0008585 female gonad development; GO:0008593 regulation of Notch signaling pathway; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010517 regulation of phospholipase activity; GO:0010518 positive regulation of phospholipase activity; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010623 programmed cell death involved in cell development; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010863 positive regulation of phospholipase C activity; GO:0010941 regulation of cell death; GO:0012501 programmed cell death; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling; GO:0014831 gastro-intestinal system smooth muscle contraction; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0017145 stem cell division; GO:0018108 pepti"}},"GO:0001669 acrosomal vesicle; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0009897 external side of plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030054 cell junction; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0099503 secretory vesicle;","GO:0002020 protease binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004714 transmembrane receptor protein tyrosine kinase activity; GO:0004888 transmembrane signaling receptor activity; GO:0005020 stem cell factor receptor activity; GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019199 transmembrane receptor protein kinase activity; GO:0019899 enzyme binding; GO:0019955 cytokine binding; GO:0031267 small GTPase binding; GO:0035004 phosphatidylinositol 3-kinase activity; GO:0038023 signaling receptor activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046934 phosphatidylinositol-4","5-bisphosphate 3-kinase activity; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0052813 phosphatidylinositol bisphosphate kinase activity; GO:0060089 molecular transducer activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF00047; PF07714","PF00047 Immunoglobulin domain; PF07714 Protein tyrosine and serine/threonine kinase","T","KOG0200","Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases","WP4262 BREAST CANCER PATHWAY;WP2406 CARDIAC PROGENITOR DIFFERENTIATION;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP4540 HIPPO SIGNALING REGULATION PATHWAYS;WP4541 HIPPOMERLIN SIGNALING DYSREGULATION;WP3640 IMATINIB AND CHRONIC MYELOID LEUKEMIA;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP4685 MELANOMA;WP4331 NEOVASCULARISATION PROCESSES;WP4172 PI3KAKT SIGNALING PATHWAY;WP2848 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY;WP4223 RAS SIGNALING","http://www.wikipathways.org/instance/WP4262_r108103;http://www.wikipathways.org/instance/WP2406_r119249;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP4540_r120395;http://www.wikipathways.org/instance/WP4541_r116745;http://www.wikipathways.org/instance/WP3640_r117152;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP4685_r119240;http://www.wikipathways.org/instance/WP4331_r107654;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP2848_r117095;http://www.wikipathways.org/instance/WP4223_r119284",null,"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1433557 Signaling by SCF-KIT;R-HSA-1433559 Regulation of KIT signaling;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-212436 Generic Transcription Pathway;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9669914 Dasatinib-resistant KIT mutants;R-HSA-9669917 Imatinib-resistant KIT mutants;R-HSA-9669921 KIT mutants bind TKIs;R-HSA-9669924 Masitinib-resistant KIT mutants;R-HSA-9669926 Nilotinib-resistant KIT mutants;R-HSA-9669929 Regorafenib-resistant KIT mutants;R-HSA-9669933 Signaling by kinase domain mutants of KIT;R-HSA-9669934 Sunitinib-resistant KIT mutants;R-HSA-9669935 Signaling by juxtamembrane domain KIT mutants;R-HSA-9669936 Sorafenib-resistant KIT mutants;R-HSA-9669937 Drug resistance of KIT mutants;R-HSA-9669938 Signaling by KIT in disease;R-HSA-9670439 Signaling by phosphorylated juxtamembrane"," extracellular and kinase domain KIT mutants;R-HSA-9680187 Signaling by extracellular domain mutants of KIT","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-1433557;https://reactome.org/PathwayBrowser/#/R-HSA-1433559;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-199418;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2219528;https://reactome.org/PathwayBrowser/#/R-HSA-2219530;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-5673001;https://reactome.org/PathwayBrowser/#/R-HSA-5683057;https://reactome.org/PathwayBrowser/#/R-HSA-5684996;https://reactome.org/PathwayBrowser/#/R-HSA-6811558;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8864260;https://reactome.org/PathwayBrowser/#/R-HSA-8866910;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9669914;https://reactome.org/PathwayBrowser/#/R-HSA-9669917;https://reactome.org/PathwayBrowser/#/R-HSA-9669921;https://reactome.org/PathwayBrowser/#/R-HSA-9669924;https://reactome.org/PathwayBrowser/#/R-HSA-9669926;https://reactome.org/PathwayBrowser/#/R-HSA-9669929;https://reactome.org/PathwayBrowser/#/R-HSA-9669933;https://reactome.org/PathwayBrowser/#/R-HSA-9669934;https://reactome.org/PathwayBrowser/#/R-HSA-9669935;https://reactome.org/PathwayBrowser/#/R-HSA-9669936;https://reactome.org/PathwayBrowser/#/R-HSA-9669937;https://reactome.org/PathwayBrowser/#/R-HSA-9669938;https://reactome.org/PathwayBrowser/#/R-HSA-9670439;https://reactome.org/PathwayBrowser/#/R-HSA-9680187","UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["P11049","Leukocyte antigen CD37 OS=Homo sapiens OX=9606 GN=CD37 PE=1 SV=2","CD37",1.043223571,0.547878779,"nochange",21955.2,22131.3,23753.8,21832.3,22733.8,26206.5,0.950353106,0.957975773,1.028207331,0.945033254,0.984055597,1.134374939,"plasma membrane","K06475","CD37; CD37 antigen","hsa04640 Hematopoietic cell lineage","GO:0001562 response to protozoan; GO:0002637 regulation of immunoglobulin production; GO:0002639 positive regulation of immunoglobulin production; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002702 positive regulation of production of molecular mediator of immune response; GO:0002831 regulation of response to biotic stimulus; GO:0002920 regulation of humoral immune response; GO:0006950 response to stress; GO:0006952 defense response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008285 negative regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009987 cellular process; GO:0023052 signaling; GO:0030885 regulation of myeloid dendritic cell activation; GO:0030886 negative regulation of myeloid dendritic cell activation; GO:0031347 regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0042127 regulation of cell population proliferation; GO:0042832 defense response to protozoan; GO:0043207 response to external biotic stimulus; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0050688 regulation of defense response to virus; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050896 response to stimulus; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0080134 regulation of response to stress; GO:0098542 defense response to other organism;","GO:0001772 immunological synapse; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0071944 cell periphery;",{"$nulls":3},"R","KOG3882","Tetraspanin family integral membrane protein","WP3945 TYROBP CAUSAL NETWORK IN MICROGLIA","http://www.wikipathways.org/instance/WP3945_r116679",{"$nulls":3},"KRAS SIGNALING UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP"]
["P11177","Pyruvate dehydrogenase E1 component subunit beta"," mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3","PDHB",0.882912818,0.014879543,"nochange",39985.9,40288.4,41853.5,35808.8,34326.3,37693.1,1.043310025,1.051202839,1.092039347,0.934321348,0.895640035,0.983486406,"mitochondria","K00162","PDHB; pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]","hsa00020 Citrate cycle (TCA cycle); hsa05415 Diabetic cardiomyopathy; hsa04066 HIF-1 signaling pathway; hsa04922 Glucagon signaling pathway; hsa00620 Pyruvate metabolism; hsa00010 Glycolysis / Gluconeogenesis; hsa01200 Carbon metabolism; hsa01100 Metabolic pathways; hsa05230 Central carbon metabolism in cancer","GO:0006082 organic acid metabolic process; GO:0006084 acetyl-CoA metabolic process; GO:0006085 acetyl-CoA biosynthetic process; GO:0006086 acetyl-CoA biosynthetic process from pyruvate; GO:0006090 pyruvate metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006099 tricarboxylic acid cycle; GO:0006101 citrate metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009060 aerobic respiration; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016999 antibiotic metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019362 pyridine nucleotide metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035383 thioester metabolic process; GO:0035384 thioester biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate; GO:0071616 acyl-CoA biosynthetic process; GO:0071704 organic substance metabolic process; GO:0072350 tricarboxylic acid metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072524 pyridine-containing compound metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045254 pyruvate dehydrogenase complex; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0004738 pyruvate dehydrogenase activity; GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity; GO:0016491 oxidoreductase activity; GO:0016624 oxidoreductase activity"," acting on the aldehyde or oxo group of donors"," disulfide as acceptor; GO:0016903 oxidoreductase activity"," acting on the aldehyde or oxo group of donors;","PF02779; PF02780","PF02779 Transketolase"," pyrimidine binding domain; PF02780 Transketolase"," C-terminal domain","C","KOG0524","Pyruvate dehydrogenase E1"," beta subunit","WP4206 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY;WP4290 METABOLIC REPROGRAMMING IN COLON CANCER;WP5094 OREXIN RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP4206_r119286;http://www.wikipathways.org/instance/WP4290_r118611;http://www.wikipathways.org/instance/WP5094_r120665",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-162582 Signal Transduction;R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex;R-HSA-389661 Glyoxylate metabolism and glycine degradation;R-HSA-5362517 Signaling by Retinoic Acid;R-HSA-70268 Pyruvate metabolism;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle;R-HSA-9006931 Signaling by Nuclear Receptors","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-204174;https://reactome.org/PathwayBrowser/#/R-HSA-389661;https://reactome.org/PathwayBrowser/#/R-HSA-5362517;https://reactome.org/PathwayBrowser/#/R-HSA-70268;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-71406;https://reactome.org/PathwayBrowser/#/R-HSA-9006931","FATTY ACID METABOLISM;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P11717","Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3","IGF2R",0.598566027,0.000253592,"down",15547.5,17589.5,16264.2,9479.16,10193,9897.72,1.181255214,1.336400617,1.235708059,0.72019985,0.774435401,0.752000859,"plasma membrane","K06564","IGF2R; insulin-like growth factor 2 receptor","hsa04142 Lysosome; hsa03266 Virion - Herpesvirus; hsa04144 Endocytosis","GO:0001101 response to acid chemical; GO:0001775 cell activation; GO:0001889 liver development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006955 immune response; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032526 response to retinoic acid; GO:0032940 secretion by cell; GO:0033993 response to lipid; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048009 insulin-like growth factor receptor signaling pathway; GO:0048193 Golgi vesicle transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0061008 hepaticobiliary system development; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0098657 import into cell; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound;","GO:0000139 Golgi membrane; GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005641 nuclear envelope lumen; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005802 trans-Golgi network; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030117 membrane coat; GO:0030118 clathrin coat; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0030140 trans-Golgi network transport vesicle; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030665 clathrin-coated vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0048475 coated membrane; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0001965 G-protein alpha-subunit binding; GO:0001972 retinoic acid binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004714 transmembrane receptor protein tyrosine kinase activity; GO:0004888 transmembrane signaling receptor activity; GO:0004930 G protein-coupled receptor activity; GO:0005010 insulin-like growth factor-activated receptor activity; GO:0005488 binding; GO:0005501 retinoid binding; GO:0005515 protein binding; GO:0005520 insulin-like growth factor binding; GO:0005537 mannose binding; GO:0008289 lipid binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019199 transmembrane receptor protein kinase activity; GO:0019838 growth factor binding; GO:0019840 isoprenoid binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030246 carbohydrate binding; GO:0031406 carboxylic acid binding; GO:0031995 insulin-like growth factor II binding; GO:0033293 monocarboxylic acid binding; GO:0036094 small molecule binding; GO:0036143 kringle domain binding; GO:0038023 signaling receptor activity; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043177 organic acid binding; GO:0048029 monosaccharide binding; GO:0051219 phosphoprotein binding; GO:0060089 molecular transducer activity; GO:0140096 catalytic activity"," acting on a protein;","PF00040","PF00040 Fibronectin type II domain","TU","KOG4504","Cation-independent mannose-6-phosphate receptor CI-MPR",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6798695 Neutrophil degranulation;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828","APOPTOSIS;IL2 STAT5 SIGNALING;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APOPTOSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["P12268","Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2","IMPDH2",0.976677634,0.301466064,"nochange",106839,113326,109004,108032,108312,105148,0.985204277,1.045023445,1.00516859,0.996205397,0.998787387,0.969610903,"cytoplasm","K00088","IMPDH; IMP dehydrogenase [EC:1.1.1.205]","hsa00983 Drug metabolism - other enzymes; hsa01232 Nucleotide metabolism; hsa00230 Purine metabolism; hsa01100 Metabolic pathways","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006183 GTP biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006955 immune response; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007423 sensory organ development; GO:0007623 circadian rhythm; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009058 biosynthetic process; GO:0009116 nucleoside metabolic process; GO:0009117 nucleotide metabolic process; GO:0009119 ribonucleoside metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009142 nucleoside triphosphate biosynthetic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009145 purine nucleoside triphosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009163 nucleoside biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009201 ribonucleoside triphosphate biosynthetic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009206 purine ribonucleoside triphosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0032943 mononuclear cell proliferation; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0034097 response to cytokine; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036230 granulocyte activation; GO:0040011 locomotion; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042278 purine nucleoside metabolic process; GO:0042330 taxis; GO:0042451 purine nucleoside biosynthetic process; GO:0042455 ribonucleoside biosynthetic process; GO:0043010 camera-type eye development; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046039 GTP metabolic process; GO:0046128 purine ribonucleoside metabolic process; GO:0046129 purine ribonucleoside biosynthetic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046649 lymphocyte activation; GO:0046651 lymphocyte proliferation; GO:0046903 secretion; GO:0048468 cell development; GO:0048511 rhythmic process; GO:0048513 animal organ development; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051262 protein tetramerization; GO:0051289 protein homotetramerization; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060041 retina development in camera-type eye; GO:0061564 axon development; GO:0065003 protein-containing complex assembly; GO:0070661 leukocyte proliferation; GO:0070670 response to interleukin-4; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071353 cellular response to interleukin-4; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:0097485 neuron projection guidance; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901068 guanosine-containing compound metabolic process; GO:1901070 guanosine-containing compound biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901657 glycosyl compound metabolic process; GO:1901659 glycosyl compound biosynthetic process;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0003938 IMP dehydrogenase activity; GO:0005488 binding; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor; GO:0036094 small molecule binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00478; PF00571","PF00478 IMP dehydrogenase / GMP reductase domain; PF00571 CBS domain","F","KOG2550","IMP dehydrogenase/GMP reductase","WP4312 RETT SYNDROME CAUSING GENES","http://www.wikipathways.org/instance/WP4312_r119230",null,"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-5663205 Infectious disease;R-HSA-6798695 Neutrophil degranulation;R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis;R-HSA-8956320 Nucleotide biosynthesis;R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections;R-HSA-9748784 Drug ADME;R-HSA-9748787 Azathioprine ADME","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-73817;https://reactome.org/PathwayBrowser/#/R-HSA-8956320;https://reactome.org/PathwayBrowser/#/R-HSA-9679191;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9748784;https://reactome.org/PathwayBrowser/#/R-HSA-9748787","DNA REPAIR;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["P12956","X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2","XRCC6",1.19971975,0.002409335,"up",257975,280804,269784,330015,318227,321807,0.870257257,0.947268994,0.910093938,1.113278219,1.073512379,1.085589212,"cytoplasm","K10884","XRCC6; ATP-dependent DNA helicase 2 subunit 1","hsa03450 Non-homologous end-joining","GO:0000723 telomere maintenance; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002200 somatic diversification of immune receptors; GO:0002218 activation of innate immune response; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002520 immune system development; GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006266 DNA ligation; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006310 DNA recombination; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006955 immune response; GO:0006970 response to osmotic stress; GO:0006972 hyperosmotic response; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009651 response to salt stress; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010165 response to X-ray; GO:0010212 response to ionizing radiation; GO:0010332 response to gamma radiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010720 positive regulation of cell development; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016444 somatic cell DNA recombination; GO:0019042 viral latency; GO:0019043 establishment of viral latency; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032200 telomere organization; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032392 DNA geometric change; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032508 DNA duplex unwinding; GO:0032940 secretion by cell; GO:0033151 V(D)J recombination; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042538 hyperosmotic salinity response; GO:0042592 homeostatic process; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045055 regulated exocytosis; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051262 protein tetramerization; GO:0051276 chromosome organization; GO:0051290 protein heterotetramerization; GO:0051291 protein heterooligomerization; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071103 DNA conformation change; GO:0071214 cellular response to abiotic stimulus; GO:0071470 cellular response to osmotic stress; GO:0071472 cellular response to salt stress; GO:0071474 cellular hyperosmotic response; GO:0071475 cellular hyperosmotic salinity response; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071480 cellular response to gamma radiation; GO:0071481 cellular response to X-ray; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0075713 establishment of integrated proviral latency; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:0097680 double-strand break repair via classical nonhomologous end joining; GO:0104004 cellular response to environmental stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000781 chromosome"," telomeric region; GO:0000782 telomere cap complex; GO:0000783 nuclear telomere cap complex; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043564 Ku70:Ku80 complex; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0070419 nonhomologous end joining complex; GO:0097708 intracellular vesicle; GO:0098687 chromosomal region; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen; GO:1990391 DNA repair complex; GO:1990904 ribonucleoprotein complex;","GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003690 double-stranded DNA binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016829 lyase activity; GO:0016835 carbon-oxygen lyase activity; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0030332 cyclin binding; GO:0042162 telomeric DNA binding; GO:0043565 sequence-specific DNA binding; GO:0044877 protein-containing complex binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0051575 5'-deoxyribose-5-phosphate lyase activity; GO:0097159 organic cyclic compound binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding;","PF03731; PF02735; PF02037","PF03731 Ku70/Ku80 N-terminal alpha/beta domain; PF02735 Ku70/Ku80 beta-barrel domain; PF02037 SAP domain","L","KOG2327","DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen)","WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP438 NONHOMOLOGOUS END JOINING","http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP438_r119305","Transcription factor","R-HSA-162587 HIV Life Cycle;R-HSA-162592 Integration of provirus;R-HSA-162594 Early Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-164843 2-LTR circle formation;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1834941 STING mediated induction of host immune responses;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-3270619 IRF3-mediated induction of type I IFN;R-HSA-5663205 Infectious disease;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693571 Nonhomologous End-Joining (NHEJ);R-HSA-6798695 Neutrophil degranulation;R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162592;https://reactome.org/PathwayBrowser/#/R-HSA-162594;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-164843;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1834941;https://reactome.org/PathwayBrowser/#/R-HSA-1834949;https://reactome.org/PathwayBrowser/#/R-HSA-3270619;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693571;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-73894","ANDROGEN RESPONSE;E2F TARGETS;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["P13667","Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2","PDIA4",1.029186676,0.160881195,"nochange",155821,150065,154324,156410,155469,161763,1.001150075,0.96416777,0.991531849,1.004934401,0.998888475,1.039327431,"extracellular","K09582","PDIA4; protein disulfide-isomerase A4 [EC:5.3.4.1]","hsa04918 Thyroid hormone synthesis; hsa05110 Vibrio cholerae infection; hsa04141 Protein processing in endoplasmic reticulum","GO:0002790 peptide secretion; GO:0006457 protein folding; GO:0006810 transport; GO:0006950 response to stress; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009306 protein secretion; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034976 response to endoplasmic reticulum stress; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0061077 chaperone-mediated protein folding; GO:0065007 biological regulation; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:1903332 regulation of protein folding; GO:1903334 positive regulation of protein folding;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005790 smooth endoplasmic reticulum; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0034663 endoplasmic reticulum chaperone complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003756 protein disulfide isomerase activity; GO:0003824 catalytic activity; GO:0015036 disulfide oxidoreductase activity; GO:0016491 oxidoreductase activity; GO:0016667 oxidoreductase activity"," acting on a sulfur group of donors; GO:0016853 isomerase activity; GO:0016860 intramolecular oxidoreductase activity; GO:0016864 intramolecular oxidoreductase activity"," transposing S-S bonds; GO:0140096 catalytic activity"," acting on a protein;","PF00085; PF13848","PF00085 Thioredoxin; PF13848 Thioredoxin-like domain","O","KOG0190","Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit)"]
["P13995","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase"," mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2","MTHFD2",0.858532275,0.014921983,"nochange",125859,137978,133349,119137,109021,112839,1.022990234,1.121494264,1.083869447,0.968353376,0.886129862,0.917162817,"mitochondria","K13403","MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 5","10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]","hsa00670 One carbon pool by folate; hsa01240 Biosynthesis of cofactors; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006730 one-carbon metabolic process; GO:0006760 folic acid-containing compound metabolic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0019752 carboxylic acid metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042558 pteridine-containing compound metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043648 dicarboxylic acid metabolic process; GO:0044237 cellular metabolic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0046653 tetrahydrofolate metabolic process; GO:0046655 folic acid metabolic process; GO:0071704 organic substance metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004477 methenyltetrahydrofolate cyclohydrolase activity; GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity; GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity; GO:0005488 binding; GO:0016491 oxidoreductase activity; GO:0016645 oxidoreductase activity"," acting on the CH-NH group of donors; GO:0016646 oxidoreductase activity"," acting on the CH-NH group of donors"," NAD or NADP as acceptor; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016814 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in cyclic amidines; GO:0019238 cyclohydrolase activity; GO:0042301 phosphate ion binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding;","PF00763; PF02882","PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase"," catalytic domain; PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase"," NAD(P)-binding domain","H","KOG0089","Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase","WP176 FOLATE METABOLISM;WP404 NUCLEOTIDE METABOLISM;WP241 ONECARBON METABOLISM;WP2525 TRANSSULFURATION AND ONECARBON METABOLISM","http://www.wikipathways.org/instance/WP176_r120275;http://www.wikipathways.org/instance/WP404_r116530;http://www.wikipathways.org/instance/WP241_r116573;http://www.wikipathways.org/instance/WP2525_r116582",null,"R-HSA-1430728 Metabolism;R-HSA-196757 Metabolism of folate and pterines;R-HSA-196849 Metabolism of water-soluble vitamins and cofactors;R-HSA-196854 Metabolism of vitamins and cofactors","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-196757;https://reactome.org/PathwayBrowser/#/R-HSA-196849;https://reactome.org/PathwayBrowser/#/R-HSA-196854","E2F TARGETS;INTERFERON GAMMA RESPONSE;MTORC1 SIGNALING;UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["P14373","Zinc finger protein RFP OS=Homo sapiens OX=9606 GN=TRIM27 PE=1 SV=1","TRIM27",0.382114487,0.000180964,"down",5358.79,5518.73,5120.12,2302.75,1992.96,1817.22,1.454179607,1.497581473,1.389413299,0.624882127,0.540816451,0.493127043,"nucleus","K12009",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000209 protein polyubiquitination; GO:0001816 cytokine production; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002790 peptide secretion; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002819 regulation of adaptive immune response; GO:0002820 negative regulation of adaptive immune response; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006469 negative regulation of protein kinase activity; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009306 protein secretion; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010959 regulation of metal ion transport; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0016567 protein ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032609 interferon-gamma production; GO:0032663 regulation of interleukin-2 production; GO:0032680 regulation of tumor necrosis factor production; GO:0032703 negative regulation of interleukin-2 production; GO:0032720 negative regulation of tumor necrosis factor production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032897 negative regulation of viral transcription; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033673 negative regulation of kinase activity; GO:0034314 Arp2/3 complex-mediated actin nucleation; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042886 amide transport; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043269 regulation of ion transport; GO:0043271 negative regulation of ion transport; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045010 actin nucleation; GO:0045087 innate immune response; GO:0045184 establishment of protein localization; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045859 regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046782 regulation of viral transcription; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048232 male gamete generation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051125 regulation of actin nucleation; GO:0051127 positive regulation of actin nucleation; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051924 regulation of calcium ion transport; GO:0051926 negative regulation of calcium ion transport; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070206 protein trimerization; GO:0070534 protein K63-linked ubiquitination; GO:0070647 protein modification by small protein conjugation or removal; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090279 regulation of calcium ion import; GO:0090281 negative regulation of calcium ion import; GO:0097435 supramolecular fiber organization; GO:0110053 regulation of actin filament organization; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production; GO:1903900 regulation of viral life cycle; GO:1903901 negative regulation of viral life cycle; GO:1904950 negative regulation of establishment of protein localization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle;","GO:0003676 nucleic acid binding; GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;","PF15227; PF00643","PF15227 zinc finger of C3HC4-type"," RING; PF00643 B-box zinc finger","O","KOG2177","Predicted E3 ubiquitin ligase",{"$nulls":3},"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3232142 SUMOylation of ubiquitinylation proteins;R-HSA-392499 Metabolism of proteins;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-6807070 PTEN Regulation;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9635465 Suppression of apoptosis;R-HSA-9635486 Infection with Mycobacterium tuberculosis;R-HSA-9637690 Response of Mtb to phagocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-3232142;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-8948751;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9635465;https://reactome.org/PathwayBrowser/#/R-HSA-9635486;https://reactome.org/PathwayBrowser/#/R-HSA-9637690"]
["P15144","Aminopeptidase N OS=Homo sapiens OX=9606 GN=ANPEP PE=1 SV=4","ANPEP",0.850473609,0.000558629,"down",67724.3,65466.1,67639.7,56217.7,56303.5,58279.5,1.093412602,1.056953837,1.09204673,0.907637903,0.909023149,0.940925779,"endoplasmic reticulum","K11140","ANPEP; aminopeptidase N [EC:3.4.11.2]","hsa00480 Glutathione metabolism; hsa04640 Hematopoietic cell lineage; hsa04614 Renin-angiotensin system; hsa01100 Metabolic pathways","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003008 system process; GO:0003013 circulatory system process; GO:0006508 proteolysis; GO:0006518 peptide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0008015 blood circulation; GO:0008152 metabolic process; GO:0008217 regulation of blood pressure; GO:0009056 catabolic process; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0032501 multicellular organismal process; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0034641 cellular nitrogen compound metabolic process; GO:0035813 regulation of renal sodium excretion; GO:0035814 negative regulation of renal sodium excretion; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043170 macromolecule metabolic process; GO:0043171 peptide catabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043603 cellular amide metabolic process; GO:0044057 regulation of system process; GO:0044062 regulation of excretion; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0098801 regulation of renal system process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005886 plasma membrane; GO:0009897 external side of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070062 extracellular exosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle; GO:1903561 extracellular vesicle;","GO:0003824 catalytic activity; GO:0004177 aminopeptidase activity; GO:0005488 binding; GO:0008233 peptidase activity; GO:0008235 metalloexopeptidase activity; GO:0008237 metallopeptidase activity; GO:0008238 exopeptidase activity; GO:0008270 zinc ion binding; GO:0016787 hydrolase activity; GO:0033218 amide binding; GO:0038023 signaling receptor activity; GO:0042277 peptide binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0060089 molecular transducer activity; GO:0070006 metalloaminopeptidase activity; GO:0140096 catalytic activity"," acting on a protein;","PF17900; PF01433; PF11838","PF17900 Peptidase M1 N-terminal domain; PF01433 Peptidase family M1 domain; PF11838 ERAP1-like C-terminal domain","EO","KOG1046","Puromycin-sensitive aminopeptidase and related aminopeptidases","WP2406 CARDIAC PROGENITOR DIFFERENTIATION;WP100 GLUTATHIONE METABOLISM","http://www.wikipathways.org/instance/WP2406_r119249;http://www.wikipathways.org/instance/WP100_r107114",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins;R-HSA-2980736 Peptide hormone metabolism;R-HSA-392499 Metabolism of proteins;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-2022377;https://reactome.org/PathwayBrowser/#/R-HSA-2980736;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-6798695","EPITHELIAL MESENCHYMAL TRANSITION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"]
["P15311","Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4","EZR",1.081584728,0.014089234,"nochange",85830.4,86010.6,88557,96804.7,91856.9,92980.9,0.950081036,0.952075721,0.980262545,1.071558675,1.016790074,1.029231949,"cytoplasm","K08007","VIL2; villin 2 (ezrin)","hsa04810 Regulation of actin cytoskeleton; hsa04670 Leukocyte transendothelial migration; hsa05130 Pathogenic Escherichia coli infection; hsa05205 Proteoglycans in cancer; hsa05206 MicroRNAs in cancer; hsa04971 Gastric acid secretion; hsa04530 Tight junction","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000226 microtubule cytoskeleton organization; GO:0000578 embryonic axis specification; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001885 endothelial cell development; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001951 intestinal D-glucose absorption; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002168 instar larval development; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003158 endothelium development; GO:0003376 sphingosine-1-phosphate receptor signaling pathway; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006810 transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006913 nucleocytoplasmic transport; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007028 cytoplasm organization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007088 regulation of mitotic nuclear division; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007159 leukocyte cell-cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007318 pole plasm protein localization; GO:0007346 regulation of mitotic cell cycle; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007368 determination of left/right symmetry; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007444 imaginal disc development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007586 digestion; GO:0007610 behavior; GO:0007617 mating behavior; GO:0007618 mating; GO:0007619 courtship behavior; GO:0008049 male courtship behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008360 regulation of cell shape; GO:0008595 anterior/posterior axis specification"," embryo; GO:0008643 carbohydrate transport; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009798 axis specification; GO:0009799 specification of symmetry; GO:0009855 determination of bilateral symmetry; GO:0009880 embryonic pattern specification; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010737 protein kinase A signaling; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016057 regulation of membrane potential in photoreceptor cell; GO:0016192 vesicle-mediated transport; GO:0016335 morphogenesis of larval imaginal disc epithelium; GO:0016336 establishment or maintenance of polarity of larval imaginal disc epithelium; GO:0016545 male courtship behavior"," veined wing vibration; GO:0019098 reproductive behavior; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022406 membrane docking; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022600 digestive system process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0022614 membrane to membrane docking; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030033 microvillus assembly; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0030953 astral microtubule organization; GO:0031122 cytoplasmic microtubule organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031503 protein-containing complex localization; GO:0031532 actin cytoskeleton reorganization; GO:0031623 receptor internalization; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032507 maintenance of protein location in cell; GO:0032528 microvillus organization; GO:0032530 regulation of microvillus organization; GO:0032532 regulation of microvillus length; GO:0032535 regulation of cellular component size; GO:0032536 regulation of cell projection size; GO:0032663 regulation of interleukin-2 production; GO:0032703 negative regulation of interleukin-2 production; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032886 regulation of microtubule-based process; GO:0032887 regulation of spindle elongation; GO:0032888 regulation of mitotic spindle elongation; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0034453 microtubule anchoring; GO:0034613 cellular protein localization; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035148 tube formation; GO:0035149 lumen formation"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0042391 regulation of membrane potential; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0043112 receptor metabolic process; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043622 cortical microtubule organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044091 membrane biogenesis; GO:0044237 cellular metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045185 maintenance of protein location; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045313 rhabdomere membrane biogenesis; GO:0045433 male courtship behavior"," veined wing generated song production; GO:0045446 endothelial cell differentiation; GO:0045732 positive regulation of protein catabolic process; GO:0045787 positive regulation of cell cycle; GO:0045807 positive regulation of endocytosis; GO:0045840 positive regulation of mitotic nuclear division; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045931 positive regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0046683 response to organophosphorus; GO:0046847 filopodium assembly; GO:0046907 intracellular transport; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048065 male courtship behavior"," veined wing extension; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050854 regulation of antigen receptor-mediated signaling pathway; GO:0050856 regulation of T cell receptor signaling pathway; GO:0050858 negative regulation of antigen receptor-mediated signaling pathway; GO:0050860 negative regulation of T cell receptor signaling pathway; GO:0050892 intestinal absorption; GO:0050896 response to stimulus; GO:0051017 actin filament bundle assembly; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051236 establishment of RNA localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051591 response to cAMP; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051649 establishment of localization in cell; GO:0051651 maintenance of location in cell; GO:0051656 establishment of organelle localization; GO:0051660 establishment of centrosome localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051983 regulation of chromosome segregation; GO:0051984 positive regulation of chromosome segregation; GO:0060179 male mating behavior; GO:0060236 regulation of mitotic spindle organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060562 epithelial tube morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0061028 establishment of endothelial barrier; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061564 axon development; GO:0061572 actin filament bundle organization; GO:0061842 microtubule organizing center localization; GO:0062033 positive regulation of mitotic sister chromatid segregation; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070373 negative regulation of ERK1 and ERK2 cascade; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071310 cellular response to organic substance; GO:0071320 cellular response to cAMP; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072499 photoreceptor cell axon guidance; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0072697 protein localization to cell cortex; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0090068 positive regulation of cell cycle process; GO:0090087 regulation of peptide transport; GO:0090224 regulation of spindle organization; GO:0090520 sphingolipid mediated signaling pathway; GO:0090596 sensory organ morphogenesis; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0098609 cell-cell adhesion; GO:0098657 import into cell; GO:0106001 intestinal hexose absorption; GO:0110028 positive regulation of mitotic spindle organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900744 regulation of p38MAPK cascade; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902115 regulation of organelle assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902846 positive regulation of mitotic spindle elongation; GO:1902896 terminal web assembly; GO:1902965 regulation of protein localization to early endosome; GO:1902966 positive regulation of protein localization to early endosome; GO:1903076 regulation of protein localization to plasma membrane; GO:1903078 positive regulation of protein localization to plasma membrane; GO:1903361 protein localization to basolateral plasma membrane; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903649 regulation of cytoplasmic transport; GO:1903651 positive regulation of cytoplasmic transport; GO:1903753 negative regulation of p38MAPK cascade; GO:1903829 positive regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904377 positive regulation of protein localization to cell periphery; GO:1904950 negative regulation of establishment of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:1905666 regulation of protein localization to endosome; GO:1905668 positive regulation of protein localization to endosome; GO:1990778 protein localization to cell periphery; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000641 regulation of early endosome to late endosome transport; GO:2000643 positive regulation of early endosome to late endosome transport; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000785 chromatin; GO:0001650 fibrillar center; GO:0001726 ruffle; GO:0001772 immunological synapse; GO:0001931 uropod; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005886 plasma membrane; GO:0005902 microvillus; GO:0005903 brush border; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0005929 cilium; GO:0005938 cell cortex; GO:0009898 cytoplasmic side of plasma membrane; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030054 cell junction; GO:0030175 filopodium; GO:0030315 T-tubule; GO:0030863 cortical cytoskeleton; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031254 cell trailing edge; GO:0031410 cytoplasmic vesicle; GO:0031528 microvillus membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032153 cell division site; GO:0032154 cleavage furrow; GO:0032991 protein-containing complex; GO:0035003 subapical complex; GO:0036064 ciliary basal body; GO:0042383 sarcolemma; GO:0042995 cell projection; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043296 apical junction complex; GO:0044297 cell body; GO:0044393 microspike; GO:0044853 plasma membrane raft; GO:0045121 membrane raft; GO:0045177 apical part of cell; GO:0045179 apical cortex; GO:0048471 perinuclear region of cytoplasm; GO:0051233 spindle midzone; GO:0051286 cell tip; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0097386 glial cell projection; GO:0097449 astrocyte projection; GO:0097454 Schwann cell microvillus; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098590 plasma membrane region; GO:0098592 cytoplasmic side of apical plasma membrane; GO:0098687 chromosomal region; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098857 membrane microdomain; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection; GO:1990023 mitotic spindle midzone;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008017 microtubule binding; GO:0008022 protein C-terminus binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0015631 tubulin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0034236 protein kinase A catalytic subunit binding; GO:0034237 protein kinase A regulatory subunit binding; GO:0035091 phosphatidylinositol binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044548 S100 protein binding; GO:0044877 protein-containing complex binding; GO:0050839 cell adhesion molecule binding; GO:0051015 actin filament binding; GO:0051018 protein kinase A binding; GO:0051117 ATPase binding; GO:0097718 disordered domain specific binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF09379; PF00373; PF09380","PF09379 FERM N-terminal domain ; PF00373 FERM central domain; PF09380 FERM C-terminal PH-like domain","R","KOG3529","Radixin"," moesin and related proteins of the ERM family","WP4949 16P112 PROXIMAL DELETION SYNDROME;WP2324 AGERAGE PATHWAY;WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION;WP51 REGULATION OF ACTIN CYTOSKELETON;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4949_r115778;http://www.wikipathways.org/instance/WP2324_r120674;http://www.wikipathways.org/instance/WP2272_r118427;http://www.wikipathways.org/instance/WP51_r116716;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1266738 Developmental Biology;R-HSA-373752 Netrin-1 signaling;R-HSA-373760 L1CAM interactions;R-HSA-422475 Axon guidance;R-HSA-437239 Recycling pathway of L1;R-HSA-9659379 Sensory processing of sound;R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea;R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea;R-HSA-9675108 Nervous system development;R-HSA-9709957 Sensory Perception","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-373752;https://reactome.org/PathwayBrowser/#/R-HSA-373760;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-437239;https://reactome.org/PathwayBrowser/#/R-HSA-9659379;https://reactome.org/PathwayBrowser/#/R-HSA-9662360;https://reactome.org/PathwayBrowser/#/R-HSA-9662361;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9709957","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["P15884","Transcription factor 4 OS=Homo sapiens OX=9606 GN=TCF4 PE=1 SV=3","TCF4",1.069056424,0.964126313,"nochange",1187.16,1031.13,1315.82,2023.06,795.111,959.992,0.974110239,0.846081649,1.079680696,1.659998198,0.652419022,0.787710196,"nucleus","K15603",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001655 urogenital system development; GO:0001708 cell fate specification; GO:0001709 cell fate determination; GO:0001775 cell activation; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007400 neuroblast fate determination; GO:0007422 peripheral nervous system development; GO:0007423 sensory organ development; GO:0007530 sex determination; GO:0007548 sex differentiation; GO:0008152 metabolic process; GO:0008406 gonad development; GO:0008407 chaeta morphogenesis; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014016 neuroblast differentiation; GO:0014017 neuroblast fate commitment; GO:0014018 neuroblast fate specification; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016525 negative regulation of angiogenesis; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030237 female sex determination; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035019 somatic stem cell population maintenance; GO:0035262 gonad morphogenesis; GO:0035295 tube development; GO:0040025 vulval development; GO:0042118 endothelial cell activation; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045137 development of primary sexual characteristics; GO:0045138 nematode male tail tip morphogenesis; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045765 regulation of angiogenesis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046661 male sex differentiation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048663 neuron fate commitment; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048863 stem cell differentiation; GO:0048865 stem cell fate commitment; GO:0048866 stem cell fate specification; GO:0048867 stem cell fate determination; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060563 neuroepithelial cell differentiation; GO:0061101 neuroendocrine cell differentiation; GO:0061326 renal tubule development; GO:0061382 Malpighian tubule tip cell differentiation; GO:0061458 reproductive system development; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072001 renal system development; GO:0072002 Malpighian tubule development; GO:0080090 regulation of primary metabolic process; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090304 nucleic acid metabolic process; GO:0090598 male anatomical structure morphogenesis; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:1900746 regulation of vascular endothelial growth factor signaling pathway; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070369 beta-catenin-TCF7L2 complex; GO:0071664 catenin-TCF7L2 complex; GO:0090575 RNA polymerase II transcription regulator complex; GO:1990907 beta-catenin-TCF complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001091 RNA polymerase II general transcription initiation factor binding; GO:0001093 TFIIB-class transcription factor binding; GO:0001098 basal transcription machinery binding; GO:0001099 basal RNA polymerase II transcription machinery binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008134 transcription factor binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043425 bHLH transcription factor binding; GO:0043565 sequence-specific DNA binding; GO:0043621 protein self-association; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0070888 E-box binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00010","PF00010 Helix-loop-helix DNA-binding domain","K","KOG3910","Helix loop helix transcription factor","WP2355 CORTICOTROPINRELEASING HORMONE SIGNALING PATHWAY;WP3892 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS;WP2853 ENDODERM DIFFERENTIATION;WP4659 GASTRIN SIGNALING PATHWAY;WP2840 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION PART 3 OF 3;WP2857 MESODERMAL COMMITMENT PATHWAY;WP2064 NEURAL CREST DIFFERENTIATION;WP3664 REGULATION OF WNT BCATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS;WP4312 RETT SYNDROME CAUSING GENES;WP363 WNT SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2355_r120664;http://www.wikipathways.org/instance/WP3892_r120069;http://www.wikipathways.org/instance/WP2853_r116557;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP2840_r117745;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP2064_r117162;http://www.wikipathways.org/instance/WP3664_r118061;http://www.wikipathways.org/instance/WP4312_r119230;http://www.wikipathways.org/instance/WP363_r120695","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-525793 Myogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-525793"]
["P16157","Ankyrin-1 OS=Homo sapiens OX=9606 GN=ANK1 PE=1 SV=3","ANK1",0.89219168,0.004623317,"down",83216.2,85099,79562.7,73664.8,73992.3,73497.5,1.064525806,1.08861113,1.017789172,0.942341522,0.946530997,0.940201372,"nucleus","K10380","ANK; ankyrin","hsa05205 Proteoglycans in cancer","GO:0002262 myeloid cell homeostasis; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006725 cellular aromatic compound metabolic process; GO:0006778 porphyrin-containing compound metabolic process; GO:0006779 porphyrin-containing compound biosynthetic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006887 exocytosis; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007163 establishment or maintenance of cell polarity; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0030011 maintenance of cell polarity; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030218 erythrocyte differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033013 tetrapyrrole metabolic process; GO:0033014 tetrapyrrole biosynthetic process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034101 erythrocyte homeostasis; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035090 maintenance of apical/basal cell polarity; GO:0042592 homeostatic process; GO:0044237 cellular metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045199 maintenance of epithelial cell apical/basal polarity; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048731 system development; GO:0048821 erythrocyte development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048872 homeostasis of number of cells; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055065 metal ion homeostasis; GO:0055072 iron ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061515 myeloid cell development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0098771 inorganic ion homeostasis; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1990778 protein localization to cell periphery;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0014731 spectrin-associated cytoskeleton; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016528 sarcoplasm; GO:0016529 sarcoplasmic reticulum; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0030424 axon; GO:0030673 axolemma; GO:0030863 cortical cytoskeleton; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031430 M band; GO:0031672 A band; GO:0031674 I band; GO:0032589 neuron projection membrane; GO:0042383 sarcolemma; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0044304 main axon; GO:0045202 synapse; GO:0045211 postsynaptic membrane; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0098590 plasma membrane region; GO:0098794 postsynapse; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008093 cytoskeletal anchor activity; GO:0019899 enzyme binding; GO:0030507 spectrin binding; GO:0030674 protein-macromolecule adaptor activity; GO:0051117 ATPase binding; GO:0060090 molecular adaptor activity;","PF17809; PF00531","PF17809 UPA domain; PF00531 Death domain","M","KOG4177","Ankyrin",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-373760 L1CAM interactions;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-445095 Interaction between L1 and Ankyrins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-447038 NrCAM interactions;R-HSA-447041 CHL1 interactions;R-HSA-447043 Neurofascin interactions;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-948021 Transport to the Golgi and subsequent modification;R-HSA-9675108 Nervous system development","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-373760;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-445095;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-447038;https://reactome.org/PathwayBrowser/#/R-HSA-447041;https://reactome.org/PathwayBrowser/#/R-HSA-447043;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-948021;https://reactome.org/PathwayBrowser/#/R-HSA-9675108","HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["P16930","Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2","FAH",0.74112256,1.602991E-3,"down",145620,136857,138151,96882.9,107584,107270,1.193011844,1.121219764,1.131821036,0.793726461,0.881396692,0.878824204,"cytoplasm","K01555","FAH; fumarylacetoacetase [EC:3.7.1.2]","hsa00350 Tyrosine metabolism; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006525 arginine metabolic process; GO:0006527 arginine catabolic process; GO:0006558 L-phenylalanine metabolic process; GO:0006559 L-phenylalanine catabolic process; GO:0006570 tyrosine metabolic process; GO:0006572 tyrosine catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009063 cellular amino acid catabolic process; GO:0009064 glutamine family amino acid metabolic process; GO:0009065 glutamine family amino acid catabolic process; GO:0009072 aromatic amino acid family metabolic process; GO:0009074 aromatic amino acid family catabolic process; GO:0009987 cellular process; GO:0016054 organic acid catabolic process; GO:0019439 aromatic compound catabolic process; GO:0019752 carboxylic acid metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0071704 organic substance metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901605 alpha-amino acid metabolic process; GO:1901606 alpha-amino acid catabolic process; GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process; GO:1902222 erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004334 fumarylacetoacetase activity; GO:0016787 hydrolase activity; GO:0016822 hydrolase activity"," acting on acid carbon-carbon bonds; GO:0016823 hydrolase activity"," acting on acid carbon-carbon bonds"," in ketonic substances;","PF09298","PF09298 Fumarylacetoacetase N-terminal","G","KOG2843","Fumarylacetoacetase","WP3925 AMINO ACID METABOLISM","http://www.wikipathways.org/instance/WP3925_r117062",null,"R-HSA-1430728 Metabolism;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-8963684 Tyrosine catabolism;R-HSA-8963691 Phenylalanine and tyrosine metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-8963684;https://reactome.org/PathwayBrowser/#/R-HSA-8963691","ADIPOGENESIS;IL2 STAT5 SIGNALING;XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["P17275","Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1","JUNB",0.819114385,0.289230235,"nochange",2976.52,2251.58,2869.78,2099.61,2853.68,1679.8,1.212351936,0.917080138,1.168876184,0.855181974,1.162318571,0.684191197,"nucleus","K09028","JUNB; transcription factor jun-B","hsa04380 Osteoclast differentiation; hsa04668 TNF signaling pathway; hsa04935 Growth hormone synthesis"," secretion and action","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001503 ossification; GO:0001568 blood vessel development; GO:0001570 vasculogenesis; GO:0001649 osteoblast differentiation; GO:0001701 in utero embryonic development; GO:0001824 blastocyst development; GO:0001825 blastocyst formation; GO:0001829 trophectodermal cell differentiation; GO:0001890 placenta development; GO:0001892 embryonic placenta development; GO:0001893 maternal placenta development; GO:0001944 vasculature development; GO:0002237 response to molecule of bacterial origin; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007565 female pregnancy; GO:0007568 aging; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008340 determination of adult lifespan; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009612 response to mechanical stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030316 osteoclast differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031667 response to nutrient levels; GO:0031960 response to corticosteroid; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032570 response to progesterone; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0033120 positive regulation of RNA splicing; GO:0033687 osteoblast proliferation; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042594 response to starvation; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043434 response to peptide hormone; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046683 response to organophosphorus; GO:0046697 decidualization; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048545 response to steroid hormone; GO:0048568 embryonic organ development; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051384 response to glucocorticoid; GO:0051385 response to mineralocorticoid; GO:0051412 response to corticosterone; GO:0051591 response to cAMP; GO:0051592 response to calcium ion; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060135 maternal process involved in female pregnancy; GO:0060136 embryonic process involved in female pregnancy; GO:0060255 regulation of macromolecule metabolic process; GO:0060674 placenta blood vessel development; GO:0060711 labyrinthine layer development; GO:0060716 labyrinthine layer blood vessel development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071277 cellular response to calcium ion; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097305 response to alcohol; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901652 response to peptide; GO:1901654 response to ketone; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035976 transcription factor AP-1 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;",null,null,"K","KOG0837","Transcriptional activator of the JUN family","WP2873 ARYL HYDROCARBON RECEPTOR PATHWAY WP2873;WP2355 CORTICOTROPINRELEASING HORMONE SIGNALING PATHWAY;WP4877 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING;WP364 IL6 SIGNALING PATHWAY;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP2374 ONCOSTATIN M SIGNALING PATHWAY;WP5094 OREXIN RECEPTOR PATHWAY;WP4879 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES;WP408 OXIDATIVE STRESS RESPONSE;WP3611 PHOTODYNAMIC THERAPYINDUCED AP1 SURVIVAL SIGNALING;WP366 TGFBETA SIGNALING PATHWAY;WP2877 VITAMIN D RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP2873_r120645;http://www.wikipathways.org/instance/WP2355_r120664;http://www.wikipathways.org/instance/WP4877_r119237;http://www.wikipathways.org/instance/WP364_r120715;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP5115_r120597;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP2374_r120781;http://www.wikipathways.org/instance/WP5094_r120665;http://www.wikipathways.org/instance/WP4879_r120399;http://www.wikipathways.org/instance/WP408_r116900;http://www.wikipathways.org/instance/WP3611_r120501;http://www.wikipathways.org/instance/WP366_r120697;http://www.wikipathways.org/instance/WP2877_r119905","Transcription factor","R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166520 Signaling by NTRKs;R-HSA-168256 Immune System;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-187037 Signaling by NTRK1 (TRKA);R-HSA-198725 Nuclear Events (kinase and transcription factor activation);R-HSA-212436 Generic Transcription Pathway;R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer;R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription;R-HSA-449147 Signaling by Interleukins;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9006936 Signaling by TGFB family members;R-HSA-9031628 NGF-stimulated transcription;R-HSA-9700206 Signaling by ALK in cancer;R-HSA-9725370 Signaling by ALK fusions and activated point mutants;R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-166520;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-170834;https://reactome.org/PathwayBrowser/#/R-HSA-187037;https://reactome.org/PathwayBrowser/#/R-HSA-198725;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2173793;https://reactome.org/PathwayBrowser/#/R-HSA-2173796;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-6785807;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9006936;https://reactome.org/PathwayBrowser/#/R-HSA-9031628;https://reactome.org/PathwayBrowser/#/R-HSA-9700206;https://reactome.org/PathwayBrowser/#/R-HSA-9725370;https://reactome.org/PathwayBrowser/#/R-HSA-9725371","REACTIVE OXYGEN SPECIES PATHWAY;TGF BETA SIGNALING;TNFA SIGNALING VIA NFKB;UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TGF_BETA_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["P17947","Transcription factor PU.1 OS=Homo sapiens OX=9606 GN=SPI1 PE=1 SV=2","SPI1",0.52256536,0.009404638,"down",5319.97,6541.26,5537.34,2672.12,2585.83,3833.94,1.204955293,1.481573366,1.254188866,0.605226183,0.585681789,0.868374502,"nucleus","K09438","SPI1; transcription factor PU.1","hsa04380 Osteoclast differentiation; hsa05221 Acute myeloid leukemia; hsa05166 Human T-cell leukemia virus 1 infection; hsa05200 Pathways in cancer; hsa05202 Transcriptional misregulation in cancer","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001568 blood vessel development; GO:0001773 myeloid dendritic cell activation; GO:0001775 cell activation; GO:0001944 vasculature development; GO:0002244 hematopoietic progenitor cell differentiation; GO:0002262 myeloid cell homeostasis; GO:0002274 myeloid leukocyte activation; GO:0002320 lymphoid progenitor cell differentiation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019827 stem cell population maintenance; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030218 erythrocyte differentiation; GO:0030225 macrophage differentiation; GO:0030851 granulocyte differentiation; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034101 erythrocyte homeostasis; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035019 somatic stem cell population maintenance; GO:0035065 regulation of histone acetylation; GO:0035067 negative regulation of histone acetylation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0043011 myeloid dendritic cell differentiation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043543 protein acylation; GO:0043966 histone H3 acetylation; GO:0044026 DNA hypermethylation; GO:0044027 hypermethylation of CpG island; GO:0044030 regulation of DNA methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045321 leukocyte activation; GO:0045346 regulation of MHC class II biosynthetic process; GO:0045347 negative regulation of MHC class II biosynthetic process; GO:0045471 response to ethanol; GO:0045595 regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045646 regulation of erythrocyte differentiation; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046649 lymphocyte activation; GO:0046677 response to antibiotic; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048872 homeostasis of number of cells; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0060033 anatomical structure regression; GO:0060255 regulation of macromolecule metabolic process; GO:0060561 apoptotic process involved in morphogenesis; GO:0061614 miRNA transcription; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071236 cellular response to antibiotic; GO:0071310 cellular response to organic substance; GO:0071361 cellular response to ethanol; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090239 regulation of histone H4 acetylation; GO:0090241 negative regulation of histone H4 acetylation; GO:0090304 nucleic acid metabolic process; GO:0097028 dendritic cell differentiation; GO:0097237 cellular response to toxic substance; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901983 regulation of protein acetylation; GO:1901984 negative regulation of protein acetylation; GO:1902262 apoptotic process involved in blood vessel morphogenesis; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902742 apoptotic process involved in development; GO:1902893 regulation of miRNA transcription; GO:1902895 positive regulation of miRNA transcription; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1905268 negative regulation of chromatin organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000756 regulation of peptidyl-lysine acetylation; GO:2000757 negative regulation of peptidyl-lysine acetylation; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0043565 sequence-specific DNA binding; GO:0051525 NFAT protein binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00178","PF00178 Ets-domain","K","KOG3805","ERG and related ETS transcription factors","WP3926 APOE AND MIR146 IN INFLAMMATION AND ATHEROSCLEROSIS;WP3892 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS;WP2849 HEMATOPOIETIC STEM CELL DIFFERENTIATION;WP3995 PRION DISEASE PATHWAY;WP2018 RANKLRANK SIGNALING PATHWAY;WP619 TYPE II INTERFERON SIGNALING IFNG","http://www.wikipathways.org/instance/WP3926_r106298;http://www.wikipathways.org/instance/WP3892_r120069;http://www.wikipathways.org/instance/WP2849_r117150;http://www.wikipathways.org/instance/WP3995_r119304;http://www.wikipathways.org/instance/WP2018_r120672;http://www.wikipathways.org/instance/WP619_r106442","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-212436 Generic Transcription Pathway;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-9616222 Transcriptional regulation of granulopoiesis","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8939236;https://reactome.org/PathwayBrowser/#/R-HSA-9616222","ALLOGRAFT REJECTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION"]
["P18850","Cyclic AMP-dependent transcription factor ATF-6 alpha OS=Homo sapiens OX=9606 GN=ATF6 PE=1 SV=3","ATF6",0.798552221,0.446245736,"nochange",2409.14,1310.48,2516.14,1947.04,1493.85,1538.69,1.288845456,0.701082624,1.346088482,1.041630481,0.799182192,0.823170764,"nucleus","K09054","ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha","hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05417 Lipid and atherosclerosis; hsa04141 Protein processing in endoplasmic reticulum; hsa05012 Parkinson disease; hsa05010 Alzheimer disease","GO:0001654 eye development; GO:0003008 system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006457 protein folding; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006984 ER-nucleus signaling pathway; GO:0006986 response to unfolded protein; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0007600 sensory perception; GO:0007601 visual perception; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0033554 cellular response to stress; GO:0034620 cellular response to unfolded protein; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress; GO:0036500 ATF6-mediated unfolded protein response; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050953 sensory perception of light stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1900101 regulation of endoplasmic reticulum unfolded protein response; GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903891 regulation of ATF6-mediated unfolded protein response; GO:1903893 positive regulation of ATF6-mediated unfolded protein response; GO:1905897 regulation of response to endoplasmic reticulum stress; GO:1905898 positive regulation of response to endoplasmic reticulum stress; GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043565 sequence-specific DNA binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;",null,null,"K","KOG4343","bZIP transcription factor ATF6","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP4861 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION;WP3613 PHOTODYNAMIC THERAPYINDUCED UNFOLDED PROTEIN RESPONSE;WP1982 STEROL REGULATORY ELEMENTBINDING PROTEINS SREBP SIGNALING;WP4925 UNFOLDED PROTEIN RESPONSE;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP4861_r118973;http://www.wikipathways.org/instance/WP3613_r106539;http://www.wikipathways.org/instance/WP1982_r116442;http://www.wikipathways.org/instance/WP4925_r112845;http://www.wikipathways.org/instance/WP3888_r116782","Transcription factor","R-HSA-2262752 Cellular responses to stress;R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum  stress;R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones;R-HSA-381042 PERK regulates gene expression;R-HSA-381119 Unfolded Protein Response (UPR);R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-380994;https://reactome.org/PathwayBrowser/#/R-HSA-381033;https://reactome.org/PathwayBrowser/#/R-HSA-381042;https://reactome.org/PathwayBrowser/#/R-HSA-381119;https://reactome.org/PathwayBrowser/#/R-HSA-381183;https://reactome.org/PathwayBrowser/#/R-HSA-8953897","UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["P19338","Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3","NCL",1.072245221,0.005018792,"nochange",354918,353952,353484,384054,370358,384692,0.967317114,0.964684314,0.963408795,1.046726306,1.009398317,1.048465154,"nucleus","K11294","NCL; nucleolin","hsa05130 Pathogenic Escherichia coli infection","GO:0000003 reproduction; GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001889 liver development; GO:0001944 vasculature development; GO:0002237 response to molecule of bacterial origin; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0006355 regulation of transcription"," DNA-templated; GO:0006356 regulation of transcription by RNA polymerase I; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006417 regulation of translation; GO:0006810 transport; GO:0006897 endocytosis; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0016192 vesicle-mediated transport; GO:0017148 negative regulation of translation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0031099 regeneration; GO:0031100 animal organ regeneration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032675 regulation of interleukin-6 production; GO:0032680 regulation of tumor necrosis factor production; GO:0032755 positive regulation of interleukin-6 production; GO:0032760 positive regulation of tumor necrosis factor production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043207 response to external biotic stimulus; GO:0044087 regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045943 positive regulation of transcription by RNA polymerase I; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048232 male gamete generation; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061008 hepaticobiliary system development; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070848 response to growth factor; GO:0070849 response to epidermal growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071363 cellular response to growth factor stimulus; GO:0071364 cellular response to epidermal growth factor stimulus; GO:0071396 cellular response to lipid; GO:0071495 cellular response to endogenous stimulus; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090069 regulation of ribosome biogenesis; GO:0090087 regulation of peptide transport; GO:0097421 liver regeneration; GO:0098657 import into cell; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I; GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production; GO:1904951 positive regulation of establishment of protein localization; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000232 regulation of rRNA processing; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0001651 dense fibrillar component; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005938 cell cortex; GO:0009986 cell surface; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0099568 cytoplasmic region; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003697 single-stranded DNA binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0019843 rRNA binding; GO:0019899 enzyme binding; GO:0035368 selenocysteine insertion sequence binding; GO:0042134 rRNA primary transcript binding; GO:0042162 telomeric DNA binding; GO:0042393 histone binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043236 laminin binding; GO:0043565 sequence-specific DNA binding; GO:0044547 DNA topoisomerase binding; GO:0046872 metal ion binding; GO:0048027 mRNA 5'-UTR binding; GO:0050840 extracellular matrix binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990631 ErbB-4 class receptor binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","AJ","KOG0123","Polyadenylate-binding protein (RRM superfamily)","WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2272_r118427;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["P19634","Sodium/hydrogen exchanger 1 OS=Homo sapiens OX=9606 GN=SLC9A1 PE=1 SV=2","SLC9A1",0.756920564,0.047872231,"nochange",2907.96,3723.29,3593.35,2280.27,2767.15,2691.79,0.971272798,1.243596987,1.200196395,0.761621282,0.924241572,0.899070965,"plasma membrane","K05742","SLC9A1; solute carrier family 9 (sodium/hydrogen exchanger)"," member 1","hsa04972 Pancreatic secretion; hsa04976 Bile secretion; hsa04919 Thyroid hormone signaling pathway; hsa04970 Salivary secretion; hsa04371 Apelin signaling pathway; hsa04261 Adrenergic signaling in cardiomyocytes; hsa04260 Cardiac muscle contraction; hsa04810 Regulation of actin cytoskeleton; hsa04024 cAMP signaling pathway; hsa05205 Proteoglycans in cancer; hsa04971 Gastric acid secretion","GO:0001558 regulation of cell growth; GO:0001654 eye development; GO:0001666 response to hypoxia; GO:0001745 compound eye morphogenesis; GO:0001952 regulation of cell-matrix adhesion; GO:0002026 regulation of the force of heart contraction; GO:0002028 regulation of sodium ion transport; GO:0003008 system process; GO:0003012 muscle system process; GO:0003013 circulatory system process; GO:0003015 heart process; GO:0006022 aminoglycan metabolic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006082 organic acid metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006813 potassium ion transport; GO:0006814 sodium ion transport; GO:0006839 mitochondrial transport; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006883 cellular sodium ion homeostasis; GO:0006885 regulation of pH; GO:0006928 movement of cell or subcellular component; GO:0006936 muscle contraction; GO:0006937 regulation of muscle contraction; GO:0006941 striated muscle contraction; GO:0006942 regulation of striated muscle contraction; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0007507 heart development; GO:0008015 blood circulation; GO:0008016 regulation of heart contraction; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009266 response to temperature stimulus; GO:0009268 response to pH; GO:0009409 response to cold; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010447 response to acidic pH; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010611 regulation of cardiac muscle hypertrophy; GO:0010613 positive regulation of cardiac muscle hypertrophy; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010765 positive regulation of sodium ion transport; GO:0010810 regulation of cell-substrate adhesion; GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0014070 response to organic cyclic compound; GO:0014706 striated muscle tissue development; GO:0014742 positive regulation of muscle hypertrophy; GO:0014743 regulation of muscle hypertrophy; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0016477 cell migration; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019722 calcium-mediated signaling; GO:0019725 cellular homeostasis; GO:0019752 carboxylic acid metabolic process; GO:0019932 second-messenger-mediated signaling; GO:0022607 cellular component assembly; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030011 maintenance of cell polarity; GO:0030029 actin filament-based process; GO:0030048 actin filament-based movement; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030203 glycosaminoglycan metabolic process; GO:0030212 hyaluronan metabolic process; GO:0030214 hyaluronan catabolic process; GO:0030307 positive regulation of cell growth; GO:0030641 regulation of cellular pH; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031644 regulation of nervous system process; GO:0032231 regulation of actin filament bundle assembly; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0034220 ion transmembrane transport; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0035051 cardiocyte differentiation; GO:0035556 intracellular signal transduction; GO:0035637 multicellular organismal signaling; GO:0035725 sodium ion transmembrane transport; GO:0035794 positive regulation of mitochondrial membrane permeability; GO:0035994 response to muscle stretch; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0036376 sodium ion export across plasma membrane; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042391 regulation of membrane potential; GO:0042592 homeostatic process; GO:0042692 muscle cell differentiation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0043502 regulation of muscle adaptation; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045760 positive regulation of action potential; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046395 carboxylic acid catabolic process; GO:0046677 response to antibiotic; GO:0046902 regulation of mitochondrial membrane permeability; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050848 regulation of calcium-mediated signaling; GO:0050850 positive regulation of calcium-mediated signaling; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051453 regulation of intracellular pH; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051602 response to electrical stimulus; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051893 regulation of focal adhesion assembly; GO:0051924 regulation of calcium ion transport; GO:0051928 positive regulation of calcium ion transport; GO:0051930 regulation of sensory perception of pain; GO:0051931 regulation of sensory perception; GO:0055007 cardiac muscle cell differentiation; GO:0055065 metal ion homeostasis; GO:0055067 monovalent inorganic cation homeostasis; GO:0055078 sodium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0055117 regulation of cardiac muscle contraction; GO:0060047 heart contraction; GO:0060048 cardiac muscle contraction; GO:0060255 regulation of macromolecule metabolic process; GO:0060537 muscle tissue development; GO:0060548 negative regulation of cell death; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0061337 cardiac conduction; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070252 actin-mediated cell contraction; GO:0070417 cellular response to cold; GO:0070482 response to oxygen levels; GO:0070884 regulation of calcineurin-NFAT signaling cascade; GO:0070886 positive regulation of calcineurin-NFAT signaling cascade; GO:0070887 cellular response to chemical stimulus; GO:0070997 neuron death; GO:0071214 cellular response to abiotic stimulus; GO:0071236 cellular response to antibiotic; GO:0071257 cellular response to electrical stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071467 cellular response to pH; GO:0071468 cellular response to acidic pH; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071805 potassium ion transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0071867 response to monoamine; GO:0071868 cellular response to monoamine stimulus; GO:0071869 response to catecholamine; GO:0071870 cellular response to catecholamine stimulus; GO:0071871 response to epinephrine; GO:0071872 cellular response to epinephrine stimulus; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0086003 cardiac muscle cell contraction; GO:0086036 regulation of cardiac muscle cell membrane potential; GO:0086092 regulation of the force of heart contraction by cardiac conduction; GO:0090109 regulation of cell-substrate junction assembly; GO:0090257 regulation of muscle system process; GO:0090559 regulation of membrane permeability; GO:0090596 sensory organ morphogenesis; GO:0098655 cation transmembrane transport; GO:0098657 import into cell; GO:0098659 inorganic cation import across plasma membrane; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098719 sodium ion import across plasma membrane; GO:0098735 positive regulation of the force of heart contraction; GO:0098739 import across plasma membrane; GO:0098771 inorganic ion homeostasis; GO:0098900 regulation of action potential; GO:0099587 inorganic ion import across plasma membrane; GO:0104004 cellular response to environmental stimulus; GO:0106056 regulation of calcineurin-mediated signaling; GO:0106058 positive regulation of calcineurin-mediated signaling; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0140115 export across plasma membrane; GO:1901019 regulation of calcium ion transmembrane transporter activity; GO:1901021 positive regulation of calcium ion transmembrane transporter activity; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901888 regulation of cell junction assembly; GO:1902305 regulation of sodium ion transmembrane transport; GO:1902307 positive regulation of sodium ion transmembrane transport; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902600 proton transmembrane transport; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1903169 regulation of calcium ion transmembrane transport; GO:1903279 regulation of calcium:sodium antiporter activity; GO:1903281 positive regulation of calcium:sodium antiporter activity; GO:1903391 regulation of adherens junction organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903510 mucopolysaccharide metabolic process; GO:1903522 regulation of blood circulation; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1904427 positive regulation of calcium ion transmembrane transport; GO:1905710 positive regulation of membrane permeability; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2000651 positive regulation of sodium ion transmembrane transporter activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005903 brush border; GO:0005911 cell-cell junction; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0014704 intercalated disc; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030315 T-tubule; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031526 brush border membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042383 sarcolemma; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044291 cell-cell contact zone; GO:0045121 membrane raft; GO:0045177 apical part of cell; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0070062 extracellular exosome; GO:0071944 cell periphery; GO:0090533 cation-transporting ATPase complex; GO:0098533 ATPase dependent transmembrane transport complex; GO:0098590 plasma membrane region; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:0098857 membrane microdomain; GO:0098862 cluster of actin-based cell projections; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1902495 transmembrane transporter complex; GO:1903561 extracellular vesicle; GO:1904949 ATPase complex; GO:1990351 transporter complex;","GO:0005198 structural molecule activity; GO:0005215 transporter activity; GO:0005451 monovalent cation:proton antiporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008289 lipid binding; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015078 proton transmembrane transporter activity; GO:0015079 potassium ion transmembrane transporter activity; GO:0015081 sodium ion transmembrane transporter activity; GO:0015291 secondary active transmembrane transporter activity; GO:0015297 antiporter activity; GO:0015298 solute:cation antiporter activity; GO:0015299 solute:proton antiporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015385 sodium:proton antiporter activity; GO:0015386 potassium:proton antiporter activity; GO:0015491 cation:cation antiporter activity; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0019904 protein domain specific binding; GO:0022804 active transmembrane transporter activity; GO:0022821 potassium ion antiporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0030165 PDZ domain binding; GO:0030346 protein phosphatase 2B binding; GO:0030674 protein-macromolecule adaptor activity; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046873 metal ion transmembrane transporter activity; GO:0048306 calcium-dependent protein binding; GO:0060090 molecular adaptor activity; GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF16644","PF16644 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin","P","KOG1966","Sodium/hydrogen exchanger protein","WP35 G PROTEIN SIGNALING PATHWAYS;WP4659 GASTRIN SIGNALING PATHWAY;WP12 OSTEOCLAST SIGNALING;WP51 REGULATION OF ACTIN CYTOSKELETON","http://www.wikipathways.org/instance/WP35_r117729;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP12_r116896;http://www.wikipathways.org/instance/WP51_r116716",null,"R-HSA-1430728 Metabolism;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-2142845 Hyaluronan metabolism;R-HSA-2160916 Hyaluronan uptake and degradation;R-HSA-382551 Transport of small molecules;R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides;R-HSA-425407 SLC-mediated transmembrane transport;R-HSA-425986 Sodium/Proton exchangers;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-2142845;https://reactome.org/PathwayBrowser/#/R-HSA-2160916;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-425393;https://reactome.org/PathwayBrowser/#/R-HSA-425407;https://reactome.org/PathwayBrowser/#/R-HSA-425986;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["P20138","Myeloid cell surface antigen CD33 OS=Homo sapiens OX=9606 GN=CD33 PE=1 SV=2","CD33",0.527830066,0.001086883,"down",17579.1,18083.9,15304.9,9099.86,8055.89,9746.64,1.35449091,1.393386361,1.179261051,0.701155216,0.620716065,0.750990397,"plasma membrane","K06473","CD33; CD33 antigen","hsa04640 Hematopoietic cell lineage","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002682 regulation of immune system process; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0006810 transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0008285 negative regulation of cell population proliferation; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0022610 biological adhesion; GO:0023052 signaling; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032940 secretion by cell; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045087 innate immune response; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050727 regulation of inflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0080134 regulation of response to stress; GO:0106014 regulation of inflammatory response to wounding; GO:0106015 negative regulation of inflammatory response to wounding; GO:1900424 regulation of defense response to bacterium; GO:1900425 negative regulation of defense response to bacterium; GO:1903034 regulation of response to wounding; GO:1903035 negative regulation of response to wounding;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0009897 external side of plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0035579 specific granule membrane; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0070820 tertiary granule; GO:0070821 tertiary granule membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098588 bounding membrane of organelle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:0101003 ficolin-1-rich granule membrane;","GO:0004888 transmembrane signaling receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019904 protein domain specific binding; GO:0030246 carbohydrate binding; GO:0031406 carboxylic acid binding; GO:0033691 sialic acid binding; GO:0036094 small molecule binding; GO:0038023 signaling receptor activity; GO:0042169 SH2 domain binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043177 organic acid binding; GO:0048029 monosaccharide binding; GO:0060089 molecular transducer activity; GO:0097367 carbohydrate derivative binding;","PF07686; PF00047","PF07686 Immunoglobulin V-set domain; PF00047 Immunoglobulin domain",{"$nulls":6},"R-HSA-1280218 Adaptive Immune System;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-198933;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["P21266","Glutathione S-transferase Mu 3 OS=Homo sapiens OX=9606 GN=GSTM3 PE=1 SV=3","GSTM3",1.271065283,0.006446905,"up",25098.8,22259.2,21721.3,28833.9,28977.9,29992.5,0.959901481,0.85130122,0.83072928,1.102750064,1.108257332,1.147060623,"cytoplasm","K00799","GST; glutathione S-transferase [EC:2.5.1.18]","hsa05204 Chemical carcinogenesis - DNA adducts; hsa00480 Glutathione metabolism; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa00982 Drug metabolism - cytochrome P450; hsa05200 Pathways in cancer; hsa05207 Chemical carcinogenesis - receptor activation; hsa05418 Fluid shear stress and atherosclerosis; hsa05225 Hepatocellular carcinoma; hsa00983 Drug metabolism - other enzymes; hsa01524 Platinum drug resistance; hsa00980 Metabolism of xenobiotics by cytochrome P450; hsa01100 Metabolic pathways","GO:0001885 endothelial cell development; GO:0002064 epithelial cell development; GO:0003158 endothelium development; GO:0006518 peptide metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006749 glutathione metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007422 peripheral nervous system development; GO:0008065 establishment of blood-nerve barrier; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009636 response to toxic substance; GO:0009888 tissue development; GO:0009987 cellular process; GO:0018916 nitrobenzene metabolic process; GO:0030154 cell differentiation; GO:0030855 epithelial cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0042178 xenobiotic catabolic process; GO:0042221 response to chemical; GO:0042537 benzene-containing compound metabolic process; GO:0043603 cellular amide metabolic process; GO:0043627 response to estrogen; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0045446 endothelial cell differentiation; GO:0048468 cell development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051410 detoxification of nitrogen compound; GO:0051716 cellular response to stimulus; GO:0060429 epithelium development; GO:0070458 cellular detoxification of nitrogen compound; GO:0070887 cellular response to chemical stimulus; GO:0071466 cellular response to xenobiotic stimulus; GO:0071704 organic substance metabolic process; GO:0097237 cellular response to toxic substance; GO:0098754 detoxification; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901685 glutathione derivative metabolic process; GO:1901687 glutathione derivative biosynthetic process; GO:1901698 response to nitrogen compound; GO:1990748 cellular detoxification;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005929 cilium; GO:0031514 motile cilium; GO:0035686 sperm fibrous sheath; GO:0036126 sperm flagellum; GO:0042995 cell projection; GO:0043226 organelle; GO:0045171 intercellular bridge; GO:0097729 9+2 motile cilium; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004364 glutathione transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0016765 transferase activity"," transferring alkyl or aryl (other than methyl) groups; GO:0019899 enzyme binding; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043295 glutathione binding; GO:0046983 protein dimerization activity; GO:0072341 modified amino acid binding; GO:1900750 oligopeptide binding; GO:1901681 sulfur compound binding;","PF02798; PF00043","PF02798 Glutathione S-transferase"," N-terminal domain; PF00043 Glutathione S-transferase"," C-terminal domain","O","KOG1695","Glutathione S-transferase","WP410 EXERCISEINDUCED CIRCADIAN REGULATION;WP702 METAPATHWAY BIOTRANSFORMATION PHASE I AND II;WP2884 NRF2 PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY","http://www.wikipathways.org/instance/WP410_r117108;http://www.wikipathways.org/instance/WP702_r106643;http://www.wikipathways.org/instance/WP2884_r106658;http://www.wikipathways.org/instance/WP2882_r117808",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-211859 Biological oxidations","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-211859","APICAL SURFACE;SPERMATOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_SURFACE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_SPERMATOGENESIS"]
["P21796","Voltage-dependent anion-selective channel protein 1 OS=Homo sapiens OX=9606 GN=VDAC1 PE=1 SV=2","VDAC1",1.268163692,0.001822624,"up",208136,221973,227150,270794,274427,288291,0.837698077,0.893388723,0.914224921,1.089881679,1.104503643,1.160302957,"cytoplasm","K05862","VDAC1; voltage-dependent anion channel protein 1","hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05166 Human T-cell leukemia virus 1 infection; hsa05415 Diabetic cardiomyopathy; hsa05131 Shigellosis; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04621 NOD-like receptor signaling pathway; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05017 Spinocerebellar ataxia; hsa04613 Neutrophil extracellular trap formation; hsa05016 Huntington disease; hsa04020 Calcium signaling pathway; hsa05164 Influenza A; hsa04979 Cholesterol metabolism; hsa04218 Cellular senescence; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa04217 Necroptosis; hsa04022 cGMP-PKG signaling pathway","GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006914 autophagy; GO:0006915 apoptotic process; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009888 tissue development; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010821 regulation of mitochondrion organization; GO:0012501 programmed cell death; GO:0015698 inorganic anion transport; GO:0016236 macroautophagy; GO:0019222 regulation of metabolic process; GO:0030154 cell differentiation; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0034220 ion transmembrane transport; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0060429 epithelium development; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0098656 anion transmembrane transport; GO:1903146 regulation of autophagy of mitochondrion;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005757 mitochondrial permeability transition pore complex; GO:0005759 mitochondrial matrix; GO:0005886 plasma membrane; GO:0009295 nucleoid; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0042645 mitochondrial nucleoid; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0046930 pore complex; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex;","GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005244 voltage-gated ion channel activity; GO:0005253 anion channel activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008308 voltage-gated anion channel activity; GO:0008509 anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015267 channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0022803 passive transmembrane transporter activity; GO:0022832 voltage-gated channel activity; GO:0022836 gated channel activity; GO:0022839 ion gated channel activity; GO:0022857 transmembrane transporter activity; GO:0042802 identical protein binding; GO:0044325 transmembrane transporter binding;",null,null,"P","KOG3126","Porin/voltage-dependent anion-selective channel protein","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468",null,"R-HSA-1268020 Mitochondrial protein import;R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-1632852 Macroautophagy;R-HSA-382551 Transport of small molecules;R-HSA-392499 Metabolism of proteins;R-HSA-5205647 Mitophagy;R-HSA-5205685 PINK1-PRKN Mediated Mitophagy;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-70268 Pyruvate metabolism;R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle;R-HSA-8949215 Mitochondrial calcium ion transport;R-HSA-9609507 Protein localization;R-HSA-9612973 Autophagy;R-HSA-9663891 Selective autophagy","https://reactome.org/PathwayBrowser/#/R-HSA-1268020;https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5205647;https://reactome.org/PathwayBrowser/#/R-HSA-5205685;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689880;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-70268;https://reactome.org/PathwayBrowser/#/R-HSA-71406;https://reactome.org/PathwayBrowser/#/R-HSA-8949215;https://reactome.org/PathwayBrowser/#/R-HSA-9609507;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9663891","MYC TARGETS V1;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P22307","Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2","SCP2",1.179744168,0.004980697,"up",47500.5,45067.8,47875.2,53218.6,54948.6,57520.2,0.930984099,0.883304495,0.938328016,1.043055765,1.076962829,1.127364797,"cytoplasm","K08764","SCP2; sterol carrier protein 2 [EC:2.3.1.176]","hsa03320 PPAR signaling pathway; hsa00120 Primary bile acid biosynthesis; hsa01040 Biosynthesis of unsaturated fatty acids; hsa04146 Peroxisome; hsa01212 Fatty acid metabolism; hsa01100 Metabolic pathways","GO:0000038 very long-chain fatty acid metabolic process; GO:0001676 long-chain fatty acid metabolic process; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003008 system process; GO:0006066 alcohol metabolic process; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006637 acyl-CoA metabolic process; GO:0006694 steroid biosynthetic process; GO:0006699 bile acid biosynthetic process; GO:0006700 C21-steroid hormone biosynthetic process; GO:0006701 progesterone biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007635 chemosensory behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008206 bile acid metabolic process; GO:0008207 C21-steroid hormone metabolic process; GO:0008306 associative learning; GO:0008355 olfactory learning; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009062 fatty acid catabolic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010817 regulation of hormone levels; GO:0010876 lipid localization; GO:0010883 regulation of lipid storage; GO:0010888 negative regulation of lipid storage; GO:0010893 positive regulation of steroid biosynthetic process; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0015031 protein transport; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015833 peptide transport; GO:0015850 organic hydroxy compound transport; GO:0015914 phospholipid transport; GO:0015918 sterol transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0016054 organic acid catabolic process; GO:0016137 glycoside metabolic process; GO:0016138 glycoside biosynthetic process; GO:0019216 regulation of lipid metabolic process; GO:0019218 regulation of steroid metabolic process; GO:0019222 regulation of metabolic process; GO:0019236 response to pheromone; GO:0019395 fatty acid oxidation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019748 secondary metabolic process; GO:0019751 polyol metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022611 dormancy process; GO:0030258 lipid modification; GO:0030301 cholesterol transport; GO:0032101 regulation of response to external stimulus; GO:0032355 response to estradiol; GO:0032368 regulation of lipid transport; GO:0032370 positive regulation of lipid transport; GO:0032371 regulation of sterol transport; GO:0032373 positive regulation of sterol transport; GO:0032374 regulation of cholesterol transport; GO:0032376 positive regulation of cholesterol transport; GO:0032377 regulation of intracellular lipid transport; GO:0032379 positive regulation of intracellular lipid transport; GO:0032380 regulation of intracellular sterol transport; GO:0032382 positive regulation of intracellular sterol transport; GO:0032383 regulation of intracellular cholesterol transport; GO:0032385 positive regulation of intracellular cholesterol transport; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0032879 regulation of localization; GO:0032957 inositol trisphosphate metabolic process; GO:0032958 inositol phosphate biosynthetic process; GO:0032959 inositol trisphosphate biosynthetic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase; GO:0033559 unsaturated fatty acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0033993 response to lipid; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034440 lipid oxidation; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034698 response to gonadotropin; GO:0034699 response to luteinizing hormone; GO:0034754 cellular hormone metabolic process; GO:0035383 thioester metabolic process; GO:0036109 alpha-linolenic acid metabolic process; GO:0036314 response to sterol; GO:0036315 cellular response to sterol; GO:0040008 regulation of growth; GO:0040012 regulation of locomotion; GO:0040024 dauer larval development; GO:0042048 olfactory behavior; GO:0042180 cellular ketone metabolic process; GO:0042181 ketone biosynthetic process; GO:0042221 response to chemical; GO:0042445 hormone metabolic process; GO:0042446 hormone biosynthetic process; GO:0042448 progesterone metabolic process; GO:0042810 pheromone metabolic process; GO:0042811 pheromone biosynthetic process; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043053 dauer entry; GO:0043054 dauer exit; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0043603 cellular amide metabolic process; GO:0043647 inositol phosphate metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0044550 secondary metabolite biosynthetic process; GO:0045184 establishment of protein localization; GO:0045540 regulation of cholesterol biosynthetic process; GO:0045542 positive regulation of cholesterol biosynthetic process; GO:0045834 positive regulation of lipid metabolic process; GO:0045927 positive regulation of growth; GO:0045940 positive regulation of steroid metabolic process; GO:0046165 alcohol biosynthetic process; GO:0046173 polyol biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046395 carboxylic acid catabolic process; GO:0046483 heterocycle metabolic process; GO:0046889 positive regulation of lipid biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048580 regulation of post-embryonic development; GO:0048582 positive regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050810 regulation of steroid biosynthetic process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0050920 regulation of chemotaxis; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0055115 entry into diapause; GO:0060341 regulation of cellular localization; GO:0060620 regulation of cholesterol import; GO:0061062 regulation of nematode larval development; GO:0061063 positive regulation of nematode larval development; GO:0062012 regulation of small molecule metabolic process; GO:0062013 positive regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070723 response to cholesterol; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071396 cellular response to lipid; GO:0071397 cellular response to cholesterol; GO:0071407 cellular response to organic cyclic compound; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0071981 exit from diapause; GO:0072329 monocarboxylic acid catabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072594 establishment of protein localization to organelle; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0080090 regulation of primary metabolic process; GO:0090181 regulation of cholesterol metabolic process; GO:0090205 positive regulation of cholesterol metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0106118 regulation of sterol biosynthetic process; GO:0106120 positive regulation of sterol biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901373 lipid hydroperoxide transport; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1901652 response to peptide; GO:1901657 glycosyl compound metabolic process; GO:1901659 glycosyl compound biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902930 regulation of alcohol biosynthetic process; GO:1902932 positive regulation of alcohol biosynthetic process; GO:1904069 ascaroside metabolic process; GO:1904070 ascaroside biosynthetic process; GO:1904109 positive regulation of cholesterol import; GO:1905952 regulation of lipid localization; GO:1905953 negative regulation of lipid localization; GO:1905954 positive regulation of lipid localization; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000909 regulation of sterol import; GO:2000911 positive regulation of sterol import;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005777 peroxisome; GO:0005782 peroxisomal matrix; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019867 outer membrane; GO:0019898 extrinsic component of membrane; GO:0031090 organelle membrane; GO:0031312 extrinsic component of organelle membrane; GO:0031315 extrinsic component of mitochondrial outer membrane; GO:0031907 microbody lumen; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;","GO:0000062 fatty-acyl-CoA binding; GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0003988 acetyl-CoA C-acyltransferase activity; GO:0005102 signaling receptor binding; GO:0005215 transporter activity; GO:0005319 lipid transporter activity; GO:0005488 binding; GO:0005496 steroid binding; GO:0005504 fatty acid binding; GO:0005515 protein binding; GO:0005548 phospholipid transporter activity; GO:0008289 lipid binding; GO:0008525 phosphatidylcholine transporter activity; GO:0008526 phosphatidylinositol transfer activity; GO:0015248 sterol transporter activity; GO:0015485 cholesterol binding; GO:0016408 C-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0031406 carboxylic acid binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0032934 sterol binding; GO:0033218 amide binding; GO:0033293 monocarboxylic acid binding; GO:0033814 propanoyl-CoA C-acyltransferase activity; GO:0036041 long-chain fatty acid binding; GO:0036042 long-chain fatty acyl-CoA binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043177 organic acid binding; GO:0043178 alcohol binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity; GO:0070538 oleic acid binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1901567 fatty acid derivative binding; GO:1901681 sulfur compound binding; GO:1904121 phosphatidylethanolamine transfer activity;","PF00108; PF02803; PF02036","PF00108 Thiolase"," N-terminal domain; PF02803 Thiolase"," C-terminal domain; PF02036 SCP-2 sterol transfer family","I","KOG4170","2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/Peroxisomal 3-ketoacyl-CoA-thiolase"," sterol-binding domain and related enzymes","WP5064 7OXOC AND 7BETAHC PATHWAYS;WP710 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT;WP368 MITOCHONDRIAL LONG CHAIN FATTY ACID BETAOXIDATION;WP4577 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP4545 OXYSTEROLS DERIVED FROM CHOLESTEROL;WP3942 PPAR SIGNALING PATHWAY;WP2878 PPARALPHA PATHWAY","http://www.wikipathways.org/instance/WP5064_r120384;http://www.wikipathways.org/instance/WP710_r116542;http://www.wikipathways.org/instance/WP368_r117795;http://www.wikipathways.org/instance/WP4577_r118444;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP4545_r120411;http://www.wikipathways.org/instance/WP3942_r106517;http://www.wikipathways.org/instance/WP2878_r116507",null,"R-HSA-1430728 Metabolism;R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism;R-HSA-2046106 alpha-linolenic acid (ALA) metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9033241 Peroxisomal protein import;R-HSA-9033500 TYSND1 cleaves peroxisomal proteins;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-2046104;https://reactome.org/PathwayBrowser/#/R-HSA-2046106;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9033500;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","ADIPOGENESIS;BILE ACID METABOLISM;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["P23381","Tryptophan--tRNA ligase"," cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2","WARS1",0.845525859,0.000520938,"down",65320.6,64341.7,64486.7,53171.4,56152.5,54834.1,1.093820662,1.077428574,1.079856659,0.890377246,0.940297008,0.918219851,"cytoplasm","K01867","WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]","hsa00970 Aminoacyl-tRNA biosynthesis","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006436 tryptophanyl-tRNA aminoacylation; GO:0006469 negative regulation of protein kinase activity; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010835 regulation of protein ADP-ribosylation; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016358 dendrite development; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033673 negative regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043436 oxoacid metabolic process; GO:0043549 regulation of kinase activity; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045765 regulation of angiogenesis; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901342 regulation of vasculature development; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004812 aminoacyl-tRNA ligase activity; GO:0004830 tryptophan-tRNA ligase activity; GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016874 ligase activity; GO:0016875 ligase activity"," forming carbon-oxygen bonds; GO:0019207 kinase regulator activity; GO:0019210 kinase inhibitor activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0098772 molecular function regulator; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF00458","PF00458 WHEP-TRS domain","J","KOG2145","Cytoplasmic tryptophanyl-tRNA synthetase","WP3925 AMINO ACID METABOLISM;WP3613 PHOTODYNAMIC THERAPYINDUCED UNFOLDED PROTEIN RESPONSE;WP465 TRYPTOPHAN METABOLISM","http://www.wikipathways.org/instance/WP3925_r117062;http://www.wikipathways.org/instance/WP3613_r106539;http://www.wikipathways.org/instance/WP465_r119262",null,"R-HSA-379716 Cytosolic tRNA aminoacylation;R-HSA-379724 tRNA Aminoacylation;R-HSA-392499 Metabolism of proteins;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-379716;https://reactome.org/PathwayBrowser/#/R-HSA-379724;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72766","ALLOGRAFT REJECTION;INTERFERON ALPHA RESPONSE;INTERFERON GAMMA RESPONSE;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["P23443","Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2","RPS6KB1",1.478871349,1.36922E-3,"up",9915.22,9317.81,9824.67,13803.5,13534.7,15634.4,0.825920758,0.776157534,0.818378099,1.149807789,1.127417212,1.302318608,"nucleus","K04688","RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]","hsa04666 Fc gamma R-mediated phagocytosis; hsa05224 Breast cancer; hsa01521 EGFR tyrosine kinase inhibitor resistance; hsa05170 Human immunodeficiency virus 1 infection; hsa04350 TGF-beta signaling pathway; hsa05221 Acute myeloid leukemia; hsa05200 Pathways in cancer; hsa05207 Chemical carcinogenesis - receptor activation; hsa04371 Apelin signaling pathway; hsa05131 Shigellosis; hsa05225 Hepatocellular carcinoma; hsa05165 Human papillomavirus infection; hsa04211 Longevity regulating pathway; hsa04714 Thermogenesis; hsa05210 Colorectal cancer; hsa05205 Proteoglycans in cancer; hsa05226 Gastric cancer; hsa04012 ErbB signaling pathway; hsa04213 Longevity regulating pathway - multiple species; hsa01522 Endocrine resistance; hsa04931 Insulin resistance; hsa04152 AMPK signaling pathway; hsa04150 mTOR signaling pathway; hsa04140 Autophagy - animal; hsa05212 Pancreatic cancer; hsa05163 Human cytomegalovirus infection; hsa05231 Choline metabolism in cancer; hsa04066 HIF-1 signaling pathway; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04151 PI3K-Akt signaling pathway; hsa04910 Insulin signaling pathway",{"$cut":{"chars":18541,"head":"GO:0000003 reproduction; GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000768 syncytium formation by plasma membrane fusion; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001101 response to acid chemical; GO:0001558 regulation of cell growth; GO:0001662 behavioral fear response; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002209 behavioral defense response; GO:0002237 response to molecule of bacterial origin; GO:0002376 immune system process; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003009 skeletal muscle contraction; GO:0003012 muscle system process; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006629 lipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006928 movement of cell or subcellular component; GO:0006936 muscle contraction; GO:0006941 striated muscle contraction; GO:0006949 syncytium formation; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006979 response to oxidative stress; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007520 myoblast fusion; GO:0007525 somatic muscle development; GO:0007528 neuromuscular junction development; GO:0007568 aging; GO:0007584 response to nutrient; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0007631 feeding behavior; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008286 insulin receptor signaling pathway; GO:0008340 determination of adult lifespan; GO:0008361 regulation of cell size; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009611 response to wounding; GO:0009612 response to mechanical stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional r"}},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005829 cytosol; GO:0009986 cell surface; GO:0016020 membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0048786 presynaptic active zone; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle; GO:0098793 presynapse;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004711 ribosomal protein S6 kinase activity; GO:0004712 protein serine/threonine/tyrosine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0019904 protein domain specific binding; GO:0030165 PDZ domain binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0033218 amide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042277 peptide binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0051721 protein phosphatase 2A binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00069","PF00069 Protein kinase domain","RT","KOG0598","Ribosomal protein S6 kinase and related proteins","WP1403 AMPACTIVATED PROTEIN KINASE AMPK SIGNALING;WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP2864 APOPTOSISRELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER;WP3676 BDNFTRKB SIGNALING;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP4262 BREAST CANCER PATHWAY;WP477 CYTOPLASMIC RIBOSOMAL PROTEINS;WP437 EGFEGFR SIGNALING PATHWAY;WP4806 EGFR TYROSINE KINASE INHIBITOR RESISTANCE;WP673 ERBB SIGNALING PATHWAY;WP3850 FACTORS AND PATHWAYS AFFECTING INSULINLIKE GROWTH FACTOR IGF1AKT SIGNALING;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP2035 FOLLICLE STIMULATING HORMONE FSH SIGNALING PATHWAY;WP4549 FRAGILE X SYNDROME;WP524 G13 SIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP4754 IL18 SIGNALING PATHWAY;WP49 IL2 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP127 IL5 SIGNALING PATHWAY;WP364 IL6 SIGNALING PATHWAY;WP481 INSULIN SIGNALING;WP3635 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION;WP3634 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION;WP585 INTERFERON TYPE I SIGNALING PATHWAYS;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP2034 LEPTIN SIGNALING PATHWAY;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP4263 PANCREATIC ADENOCARCINOMA PATHWAY;WP4172 PI3KAKT SIGNALING PATHWAY;WP2037 PROLACTIN SIGNALING PATHWAY;WP4539 SYNAPTIC SIGNALING PATHWAYS ASSOCIATED WITH AUTISM SPECTRUM DISORDER;WP1471 TARGET OF RAPAMYCIN TOR SIGNALING;WP4321 THERMOGENESIS;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS;WP2032 THYROID STIMULATING HORMONE TSH SIGNALING PATHWAY;WP4566 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP1403_r116516;http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP2864_r108133;http://www.wikipathways.org/instance/WP3676_r116809;http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP4262_r108103;http://www.wikipathways.org/instance/WP477_r117044;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP4806_r116801;http://www.wikipathways.org/instance/WP673_r118930;http://www.wikipathways.org/instance/WP3850_r110688;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP2035_r120721;http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP524_r117113;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP49_r120703;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP127_r120669;http://www.wikipathways.org/instance/WP364_r120715;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP3635_r116600;http://www.wikipathways.org/instance/WP3634_r116602;http://www.wikipathways.org/instance/WP585_r107188;http://www.wikipathways.org/instance/WP2332_r120725;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP2034_r120670;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP4263_r105482;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP2037_r116779;http://www.wikipathways.org/instance/WP4539_r113659;http://www.wikipathways.org/instance/WP1471_r116793;http://www.wikipathways.org/instance/WP4321_r106178;http://www.wikipathways.org/instance/WP4746_r120402;http://www.wikipathways.org/instance/WP2032_r120723;http://www.wikipathways.org/instance/WP4566_r104315;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-162582 Signal Transduction;R-HSA-165159 MTOR signalling;R-HSA-166208 mTORC1-mediated signalling","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-165159;https://reactome.org/PathwayBrowser/#/R-HSA-166208"]
["P24539","ATP synthase F(0) complex subunit B1"," mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PB PE=1 SV=2","ATP5PB",1.103336506,0.057535305,"nochange",84485.6,83500.4,89501.9,94165.9,99917.7,90012.2,0.935983856,0.9250692,0.991557538,1.043228221,1.106950228,0.997210957,"mitochondria","K02127","ATPeF0B; F-type H+-transporting ATPase subunit b","hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006754 ATP biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006839 mitochondrial transport; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007007 inner mitochondrial membrane organization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009142 nucleoside triphosphate biosynthetic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009145 purine nucleoside triphosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009201 ribonucleoside triphosphate biosynthetic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009206 purine ribonucleoside triphosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0015985 energy coupled proton transport"," down electrochemical gradient; GO:0015986 ATP synthesis coupled proton transport; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0034220 ion transmembrane transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042407 cristae formation; GO:0042776 mitochondrial ATP synthesis coupled proton transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046034 ATP metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061024 membrane organization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902600 proton transmembrane transport; GO:1990542 mitochondrial transmembrane transport;","GO:0000276 mitochondrial proton-transporting ATP synthase complex"," coupling factor F(o); GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005753 mitochondrial proton-transporting ATP synthase complex; GO:0005759 mitochondrial matrix; GO:0005929 cilium; GO:0016020 membrane; GO:0016469 proton-transporting two-sector ATPase complex; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033177 proton-transporting two-sector ATPase complex"," proton-transporting domain; GO:0042995 cell projection; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045259 proton-transporting ATP synthase complex; GO:0045263 proton-transporting ATP synthase complex"," coupling factor F(o); GO:0070013 intracellular organelle lumen; GO:0097730 non-motile cilium; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0120025 plasma membrane bounded cell projection;","GO:0005215 transporter activity; GO:0022857 transmembrane transporter activity;",null,null,"C","KOG3976","Mitochondrial F1F0-ATP synthase"," subunit b/ATP4","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP623 OXIDATIVE PHOSPHORYLATION","http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP623_r107189",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-1592230 Mitochondrial biogenesis;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-163210 Formation of ATP by chemiosmotic coupling;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-8949613 Cristae formation","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-163210;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-8949613","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P25098","Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2","GRK2",0.870385414,0.00048731,"down",61240.7,59841.7,59505.3,51788.9,53452.2,51939.8,1.087857782,1.063006449,1.05703076,0.919959404,0.949505667,0.922639938,"cytoplasm","K00910","ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]","hsa04062 Chemokine signaling pathway; hsa05032 Morphine addiction; hsa04724 Glutamatergic synapse; hsa04340 Hedgehog signaling pathway; hsa04144 Endocytosis; hsa04740 Olfactory transduction","GO:0000003 reproduction; GO:0000302 response to reactive oxygen species; GO:0001505 regulation of neurotransmitter levels; GO:0001541 ovarian follicle development; GO:0001678 cellular glucose homeostasis; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002026 regulation of the force of heart contraction; GO:0002029 desensitization of G protein-coupled receptor signaling pathway; GO:0002031 G protein-coupled receptor internalization; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0003012 muscle system process; GO:0003013 circulatory system process; GO:0003015 heart process; GO:0003018 vascular process in circulatory system; GO:0003057 regulation of the force of heart contraction by chemical signal; GO:0003108 negative regulation of the force of heart contraction by chemical signal; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006935 chemotaxis; GO:0006936 muscle contraction; GO:0006937 regulation of muscle contraction; GO:0006941 striated muscle contraction; GO:0006942 regulation of striated muscle contraction; GO:0006950 response to stress; GO:0006970 response to osmotic stress; GO:0006972 hyperosmotic response; GO:0006979 response to oxidative stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007213 G protein-coupled acetylcholine receptor signaling pathway; GO:0007217 tachykinin receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007507 heart development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007568 aging; GO:0007602 phototransduction; GO:0007603 phototransduction",{"$cut":{"chars":17637,"head":" visible light; GO:0007610 behavior; GO:0007635 chemosensory behavior; GO:0008015 blood circulation; GO:0008016 regulation of heart contraction; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008284 positive regulation of cell population proliferation; GO:0008406 gonad development; GO:0008585 female gonad development; GO:0008589 regulation of smoothened signaling pathway; GO:0009056 catabolic process; GO:0009314 response to radiation; GO:0009410 response to xenobiotic stimulus; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009584 detection of visible light; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010243 response to organonitrogen compound; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010660 regulation of muscle cell apoptotic process; GO:0010661 positive regulation of muscle cell apoptotic process; GO:0010799 regulation of peptidyl-threonine phosphorylation; GO:0010801 negative regulation of peptidyl-threonine phosphorylation; GO:0010827 regulation of glucose transmembrane transport; GO:0010829 negative regulation of glucose transmembrane transport; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0014072 response to isoquinoline alkaloid; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016032 viral process; GO:0016059 deactivation of rhodopsin mediated signaling; GO:0016060 metarhodopsin inactivation; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018107 peptidyl-threonine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0018210 peptidyl-threonine modification; GO:0018958 phenol-containing compound metabolic process; GO:0019058 viral life cycle; GO:0019079 viral genome replication; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019229 regulation of vasoconstriction; GO:0019336 phenol-containing compound catabolic process; GO:0019439 aromatic compound catabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0022400 regulation of rhodopsin mediated signaling pathway; GO:0022401 negative adaptation of signaling pathway; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022602 ovulation cycle process; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regul"}},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005901 caveola; GO:0005929 cilium; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043197 dendritic spine; GO:0043198 dendritic shaft; GO:0043226 organelle; GO:0044309 neuron spine; GO:0044853 plasma membrane raft; GO:0045121 membrane raft; GO:0045177 apical part of cell; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098590 plasma membrane region; GO:0098794 postsynapse; GO:0098857 membrane microdomain; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0001664 G protein-coupled receptor binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004703 G protein-coupled receptor kinase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0030554 adenyl nucleotide binding; GO:0031625 ubiquitin protein ligase binding; GO:0031628 opioid receptor binding; GO:0031690 adrenergic receptor binding; GO:0031694 alpha-2A adrenergic receptor binding; GO:0031753 endothelial differentiation G protein-coupled receptor binding; GO:0031755 Edg-2 lysophosphatidic acid receptor binding; GO:0031850 delta-type opioid receptor binding; GO:0031851 kappa-type opioid receptor binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035091 phosphatidylinositol binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0047696 beta-adrenergic receptor kinase activity; GO:0050254 rhodopsin kinase activity; GO:0097110 scaffold protein binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00615; PF00069; PF00169","PF00615 Regulator of G protein signaling domain; PF00069 Protein kinase domain; PF00169 PH domain","T","KOG0986","G protein-coupled receptor kinase","WP3929 CHEMOKINE SIGNALING PATHWAY;WP4249 HEDGEHOG SIGNALING PATHWAY WP4249;WP47 HEDGEHOG SIGNALING PATHWAY WP47","http://www.wikipathways.org/instance/WP3929_r119247;http://www.wikipathways.org/instance/WP4249_r117749;http://www.wikipathways.org/instance/WP47_r120579",null,"R-HSA-111885 Opioid Signalling;R-HSA-111933 Calmodulin induced events;R-HSA-111996 Ca-dependent events;R-HSA-111997 CaM pathway;R-HSA-112040 G-protein mediated events;R-HSA-112043 PLC beta mediated events;R-HSA-1489509 DAG and IP3 signaling;R-HSA-162582 Signal Transduction;R-HSA-199991 Membrane Trafficking;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-416476 G alpha (q) signalling events;R-HSA-418555 G alpha (s) signalling events;R-HSA-418594 G alpha (i) signalling events;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5632684 Hedgehog 'on' state;R-HSA-5635838 Activation of SMO;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9006925 Intracellular signaling by second messengers","https://reactome.org/PathwayBrowser/#/R-HSA-111885;https://reactome.org/PathwayBrowser/#/R-HSA-111933;https://reactome.org/PathwayBrowser/#/R-HSA-111996;https://reactome.org/PathwayBrowser/#/R-HSA-111997;https://reactome.org/PathwayBrowser/#/R-HSA-112040;https://reactome.org/PathwayBrowser/#/R-HSA-112043;https://reactome.org/PathwayBrowser/#/R-HSA-1489509;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-416476;https://reactome.org/PathwayBrowser/#/R-HSA-418555;https://reactome.org/PathwayBrowser/#/R-HSA-418594;https://reactome.org/PathwayBrowser/#/R-HSA-5358351;https://reactome.org/PathwayBrowser/#/R-HSA-5632684;https://reactome.org/PathwayBrowser/#/R-HSA-5635838;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9006925","PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["P25791","Rhombotin-2 OS=Homo sapiens OX=9606 GN=LMO2 PE=1 SV=1","LMO2",1.026989792,0.713620875,"nochange",8444.56,7223.3,7893.27,7311.84,8598.96,8286.24,1.060915022,0.90748452,0.991654831,0.918608062,1.080312751,1.041024813,"nucleus","K15612","LMO2; rhombotin-2","hsa05202 Transcriptional misregulation in cancer","GO:0001568 blood vessel development; GO:0001654 eye development; GO:0001935 endothelial cell proliferation; GO:0001944 vasculature development; GO:0002262 myeloid cell homeostasis; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009299 mRNA transcription; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030218 erythrocyte differentiation; GO:0031099 regeneration; GO:0031101 fin regeneration; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0034101 erythrocyte homeostasis; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035162 embryonic hemopoiesis; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040007 growth; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042246 tissue regeneration; GO:0042592 homeostatic process; GO:0042789 mRNA transcription by RNA polymerase II; GO:0043010 camera-type eye development; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045638 negative regulation of myeloid cell differentiation; GO:0045646 regulation of erythrocyte differentiation; GO:0045647 negative regulation of erythrocyte differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048568 embryonic organ development; GO:0048589 developmental growth; GO:0048731 system development; GO:0048821 erythrocyte development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048872 homeostasis of number of cells; GO:0050673 epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060041 retina development in camera-type eye; GO:0060255 regulation of macromolecule metabolic process; GO:0061298 retina vasculature development in camera-type eye; GO:0061299 retina vasculature morphogenesis in camera-type eye; GO:0061304 retinal blood vessel morphogenesis; GO:0061515 myeloid cell development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097066 response to thyroid hormone; GO:0097067 cellular response to thyroid hormone stimulus; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901532 regulation of hematopoietic progenitor cell differentiation; GO:1901576 organic substance biosynthetic process; GO:1902036 regulation of hematopoietic stem cell differentiation; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000736 regulation of stem cell differentiation; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0043425 bHLH transcription factor binding; GO:0043565 sequence-specific DNA binding; GO:0070888 E-box binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00412","PF00412 LIM domain","R","KOG0490","Transcription factor"," contains HOX domain","WP2849 HEMATOPOIETIC STEM CELL DIFFERENTIATION","http://www.wikipathways.org/instance/WP2849_r117150","Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8939236","HEME METABOLISM;PANCREAS BETA CELLS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PANCREAS_BETA_CELLS"]
["P26368","Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4","U2AF2",1.360088457,{"v":2.15716e-05,"d":"2.16E-05"},"up",140290,138045,140401,190396,193549,185573,0.851744592,0.838114493,0.852418508,1.155953834,1.175096686,1.126671888,"nucleus","K12837","U2AF2; splicing factor U2AF 65 kDa subunit","hsa03040 Spliceosome","GO:0000003 reproduction; GO:0000245 spliceosomal complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000389 mRNA 3'-splice site recognition; GO:0000398 mRNA splicing"," via spliceosome; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006376 mRNA splice site selection; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010172 embryonic body morphogenesis; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030154 cell differentiation; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031503 protein-containing complex localization; GO:0032239 regulation of nucleobase-containing compound transport; GO:0032241 positive regulation of nucleobase-containing compound transport; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033119 negative regulation of RNA splicing; GO:0033120 positive regulation of RNA splicing; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0040007 growth; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046831 regulation of RNA export from nucleus; GO:0046833 positive regulation of RNA export from nucleus; GO:0046907 intracellular transport; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048025 negative regulation of mRNA splicing"," via spliceosome; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050684 regulation of mRNA processing; GO:0050686 negative regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051028 mRNA transport; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal;","GO:0000243 commitment complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071004 U2-type prespliceosome; GO:0071010 prespliceosome; GO:0089701 U2AF complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008187 poly-pyrimidine tract binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030628 pre-mRNA 3'-splice site binding; GO:0036002 pre-mRNA binding; GO:0070742 C2H2 zinc finger domain binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","A","KOG0120","Splicing factor U2AF"," large subunit (RRM superfamily)","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160","Transcription factor","R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["P27105","Stomatin OS=Homo sapiens OX=9606 GN=STOM PE=1 SV=3","STOM",1.272163673,0.007606988,"up",163743,149221,152550,206802,203049,182359,0.92884155,0.846464673,0.865348616,1.173096195,1.151807088,1.034441877,"cytoplasm","K17286",null,null,"GO:0001775 cell activation; GO:0002028 regulation of sodium ion transport; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0009987 cellular process; GO:0010959 regulation of metal ion transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022607 cellular component assembly; GO:0022898 regulation of transmembrane transporter activity; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032409 regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0033157 regulation of intracellular protein transport; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0035821 modulation of process of another organism; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043269 regulation of ion transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044788 modulation by host of viral process; GO:0044794 positive regulation by host of viral process; GO:0044827 modulation by host of viral genome replication; GO:0044829 positive regulation by host of viral genome replication; GO:0045055 regulated exocytosis; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048524 positive regulation of viral process; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051702 biological process involved in interaction with symbiont; GO:0051851 modulation by host of symbiont process; GO:0060341 regulation of cellular localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0071840 cellular component organization or biogenesis; GO:0090087 regulation of peptide transport; GO:0090313 regulation of protein targeting to membrane; GO:0090314 positive regulation of protein targeting to membrane; GO:0090316 positive regulation of intracellular protein transport; GO:1901585 regulation of acid-sensing ion channel activity; GO:1902305 regulation of sodium ion transmembrane transport; GO:1903533 regulation of protein targeting; GO:1903829 positive regulation of protein localization; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:1904062 regulation of cation transmembrane transport; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2001257 regulation of cation channel activity;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005783 endoplasmic reticulum; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0035577 azurophil granule membrane; GO:0035579 specific granule membrane; GO:0042581 specific granule; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045121 membrane raft; GO:0048471 perinuclear region of cytoplasm; GO:0070820 tertiary granule; GO:0070821 tertiary granule membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0098857 membrane microdomain; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0070063 RNA polymerase binding;",null,null,"C","KOG2621","Prohibitins and stomatins of the PID superfamily","WP4352 CILIARY LANDSCAPE;WP2880 GLUCOCORTICOID RECEPTOR PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP2880_r117734;http://www.wikipathways.org/instance/WP2882_r117808",null,"R-HSA-162582 Signal Transduction;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194315 Signaling by Rho GTPases;R-HSA-2672351 Stimuli-sensing channels;R-HSA-382551 Transport of small molecules;R-HSA-6798695 Neutrophil degranulation;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013407 RHOH GTPase cycle;R-HSA-9013409 RHOJ GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-983712 Ion channel transport","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-2672351;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013407;https://reactome.org/PathwayBrowser/#/R-HSA-9013409;https://reactome.org/PathwayBrowser/#/R-HSA-9716542;https://reactome.org/PathwayBrowser/#/R-HSA-983712","ADIPOGENESIS;P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["P28066","Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3","PSMA5",1.056004105,0.20708997,"nochange",59903,64615.3,67830.1,66833.8,67563.6,68723.3,0.908839654,0.980333988,1.029108469,1.013992749,1.025065169,1.04265997,"cytoplasm","K02729","PSMA5; 20S proteasome subunit alpha 5 [EC:3.4.25.1]","hsa05017 Spinocerebellar ataxia; hsa05016 Huntington disease; hsa03050 Proteasome; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0016192 vesicle-mediated transport; GO:0016579 protein deubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0032940 secretion by cell; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000502 proteasome complex; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005839 proteasome core complex; GO:0012505 endomembrane system; GO:0019773 proteasome core complex"," alpha-subunit complex; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1902494 catalytic complex; GO:1904813 ficolin-1-rich granule lumen; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;","GO:0005488 binding; GO:0005515 protein binding;","PF00227","PF00227 Proteasome subunit","O","KOG0176","20S proteasome"," regulatory subunit alpha type PSMA5/PUP2","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)"]
["P28290","Protein ITPRID2 OS=Homo sapiens OX=9606 GN=ITPRID2 PE=1 SV=3","ITPRID2",1.173280524,0.015730439,"nochange",7926.07,8240.78,7525.83,9816.84,8924.36,9056.96,0.923589905,0.96026167,0.876951706,1.143912976,1.039916226,1.055367518,"nucleus",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;"]
["P29597","Non-receptor tyrosine-protein kinase TYK2 OS=Homo sapiens OX=9606 GN=TYK2 PE=1 SV=3","TYK2",0.534897714,0.010275968,"nochange",5247.44,4354.81,3776.85,2772.89,2409.69,1973.87,1.533177344,1.272372057,1.103505872,0.810172603,0.704054189,0.576717935,"mitochondria","K11219","TYK2; non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]","hsa04380 Osteoclast differentiation; hsa05160 Hepatitis C; hsa05161 Hepatitis B; hsa05169 Epstein-Barr virus infection; hsa05168 Herpes simplex virus 1 infection; hsa05165 Human papillomavirus infection; hsa04621 NOD-like receptor signaling pathway; hsa05145 Toxoplasmosis; hsa04630 JAK-STAT signaling pathway; hsa05171 Coronavirus disease - COVID-19; hsa05162 Measles; hsa04658 Th1 and Th2 cell differentiation; hsa05164 Influenza A; hsa04659 Th17 cell differentiation; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa04217 Necroptosis","GO:0002376 immune system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019221 cytokine-mediated signaling pathway; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0032502 developmental process; GO:0034097 response to cytokine; GO:0034340 response to type I interferon; GO:0035722 interleukin-12-mediated signaling pathway; GO:0036211 protein modification process; GO:0038083 peptidyl-tyrosine autophosphorylation; GO:0038155 interleukin-23-mediated signaling pathway; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0046777 protein autophosphorylation; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060337 type I interferon signaling pathway; GO:0065007 biological regulation; GO:0070106 interleukin-27-mediated signaling pathway; GO:0070671 response to interleukin-12; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071349 cellular response to interleukin-12; GO:0071357 cellular response to type I interferon; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0016020 membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane;","GO:0001664 G protein-coupled receptor binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004715 non-membrane spanning protein tyrosine kinase activity; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005131 growth hormone receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0031701 angiotensin receptor binding; GO:0031702 type 1 angiotensin receptor binding; GO:0051427 hormone receptor binding; GO:0140096 catalytic activity"," acting on a protein;","PF18379; PF18377; PF17887; PF07714","PF18379 FERM F1 ubiquitin-like domain; PF18377 FERM F2 acyl-CoA binding protein-like domain; PF17887 Jak1 pleckstrin homology-like domain; PF07714 Protein tyrosine and serine/threonine kinase","T","KOG0197","Tyrosine kinases","WP4666 HEPATITIS B INFECTION;WP4880 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION;WP395 IL4 SIGNALING PATHWAY;WP364 IL6 SIGNALING PATHWAY;WP4197 IMMUNE RESPONSE TO TUBERCULOSIS;WP585 INTERFERON TYPE I SIGNALING PATHWAYS;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP4630 MEASLES VIRUS INFECTION;WP4341 NONGENOMIC ACTIONS OF 125 DIHYDROXYVITAMIN D3;WP2374 ONCOSTATIN M SIGNALING PATHWAY;WP4558 OVERVIEW OF INTERFERONSMEDIATED SIGNALING PATHWAY;WP4538 REGULATORY CIRCUITS OF THE STAT3 SIGNALING PATHWAY;WP4912 SARS CORONAVIRUS AND INNATE IMMUNITY;WP5098 TCELL ACTIVATION SARSCOV2;WP4868 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARSCOV2 INFECTION;WP2113 TYPE III INTERFERON SIGNALING","http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP4880_r119113;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP364_r120715;http://www.wikipathways.org/instance/WP4197_r120647;http://www.wikipathways.org/instance/WP585_r107188;http://www.wikipathways.org/instance/WP2332_r120725;http://www.wikipathways.org/instance/WP4630_r120771;http://www.wikipathways.org/instance/WP4341_r107169;http://www.wikipathways.org/instance/WP2374_r120781;http://www.wikipathways.org/instance/WP4558_r107928;http://www.wikipathways.org/instance/WP4538_r104390;http://www.wikipathways.org/instance/WP4912_r115852;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP4868_r120021;http://www.wikipathways.org/instance/WP2113_r105848",null,"R-HSA-1059683 Interleukin-6 signaling;R-HSA-110056 MAPK3 (ERK1) activation;R-HSA-112409 RAF-independent MAPK1/3 activation;R-HSA-112411 MAPK1 (ERK2) activation;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-447115 Interleukin-12 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-449836 Other interleukin signaling;R-HSA-5663205 Infectious disease;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6783589 Interleukin-6 family signaling;R-HSA-6783783 Interleukin-10 signaling;R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling;R-HSA-6788467 IL-6-type cytokine receptor ligand interactions;R-HSA-8854691 Interleukin-20 family signaling;R-HSA-8984722 Interleukin-35 Signalling;R-HSA-9020591 Interleukin-12 signaling;R-HSA-9020933 Interleukin-23 signaling;R-HSA-9020956 Interleukin-27 signaling;R-HSA-909733 Interferon alpha/beta signaling;R-HSA-912694 Regulation of IFNA/IFNB signaling;R-HSA-913531 Interferon Signaling;R-HSA-9674555 Signaling by CSF3 (G-CSF);R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions","https://reactome.org/PathwayBrowser/#/R-HSA-1059683;https://reactome.org/PathwayBrowser/#/R-HSA-110056;https://reactome.org/PathwayBrowser/#/R-HSA-112409;https://reactome.org/PathwayBrowser/#/R-HSA-112411;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-447115;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-449836;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5683057;https://reactome.org/PathwayBrowser/#/R-HSA-5684996;https://reactome.org/PathwayBrowser/#/R-HSA-6783589;https://reactome.org/PathwayBrowser/#/R-HSA-6783783;https://reactome.org/PathwayBrowser/#/R-HSA-6785807;https://reactome.org/PathwayBrowser/#/R-HSA-6788467;https://reactome.org/PathwayBrowser/#/R-HSA-8854691;https://reactome.org/PathwayBrowser/#/R-HSA-8984722;https://reactome.org/PathwayBrowser/#/R-HSA-9020591;https://reactome.org/PathwayBrowser/#/R-HSA-9020933;https://reactome.org/PathwayBrowser/#/R-HSA-9020956;https://reactome.org/PathwayBrowser/#/R-HSA-909733;https://reactome.org/PathwayBrowser/#/R-HSA-912694;https://reactome.org/PathwayBrowser/#/R-HSA-913531;https://reactome.org/PathwayBrowser/#/R-HSA-9674555;https://reactome.org/PathwayBrowser/#/R-HSA-9679191;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9705462;https://reactome.org/PathwayBrowser/#/R-HSA-9705671;https://reactome.org/PathwayBrowser/#/R-HSA-9705683","IL6 JAK STAT3 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL6_JAK_STAT3_SIGNALING"]
["P29966","Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4","MARCKS",0.81096885,0.263120536,"nochange",5612.34,5865.71,7283.99,6230.63,5282.65,3702.15,0.991069671,1.035811672,1.286262338,1.10025202,0.932850504,0.653753796,"nucleus","K12561","MARCKS; myristoylated alanine-rich C-kinase substrate","hsa04666 Fc gamma R-mediated phagocytosis; hsa05206 MicroRNAs in cancer","GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0003229 ventricular cardiac muscle tissue development; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007155 cell adhesion; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0008104 protein localization; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010517 regulation of phospholipase activity; GO:0010518 positive regulation of phospholipase activity; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0014706 striated muscle tissue development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031584 activation of phospholipase D activity; GO:0031589 cell-substrate adhesion; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033674 positive regulation of kinase activity; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046324 regulation of glucose import; GO:0046326 positive regulation of glucose import; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0051017 actin filament bundle assembly; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051764 actin crosslink formation; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060191 regulation of lipase activity; GO:0060193 positive regulation of lipase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060537 muscle tissue development; GO:0060998 regulation of dendritic spine development; GO:0060999 positive regulation of dendritic spine development; GO:0061001 regulation of dendritic spine morphogenesis; GO:0061003 positive regulation of dendritic spine morphogenesis; GO:0061572 actin filament bundle organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0097435 supramolecular fiber organization; GO:0099175 regulation of postsynapse organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1900019 regulation of protein kinase C activity; GO:1900020 positive regulation of protein kinase C activity; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900078 positive regulation of cellular response to insulin stimulus; GO:2000026 regulation of multicellular organismal development;","GO:0000323 lytic vacuole; GO:0001520 outer dense fiber; GO:0001674 female germ cell nucleus; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031514 motile cilium; GO:0032059 bleb; GO:0032432 actin filament bundle; GO:0032991 protein-containing complex; GO:0033391 chromatoid body; GO:0035770 ribonucleoprotein granule; GO:0036126 sperm flagellum; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0042585 germinal vesicle; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043073 germ cell nucleus; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0044307 dendritic branch; GO:0044309 neuron spine; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0097729 9+2 motile cilium; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1990904 ribonucleoprotein complex;","GO:0001786 phosphatidylserine binding; GO:0003779 actin binding; GO:0005080 protein kinase C binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0005543 phospholipid binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding; GO:0072341 modified amino acid binding;",{"$nulls":5},"WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2380_r120727",null,"R-HSA-1430728 Metabolism;R-HSA-163685 Integration of energy metabolism;R-HSA-399997 Acetylcholine regulates insulin secretion;R-HSA-422356 Regulation of insulin secretion","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163685;https://reactome.org/PathwayBrowser/#/R-HSA-399997;https://reactome.org/PathwayBrowser/#/R-HSA-422356","G2M CHECKPOINT;MITOTIC SPINDLE;TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["P30154","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3","PPP2R1B",0.799228811,0.007441719,"down",26799.5,30859.1,27819.8,22487.1,22421.6,23408.1,1.045526778,1.203903633,1.085331662,0.877287458,0.874732111,0.913218358,"cytoplasm","K03456","PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A","hsa05160 Hepatitis C; hsa05142 Chagas disease; hsa04350 TGF-beta signaling pathway; hsa04261 Adrenergic signaling in cardiomyocytes; hsa04530 Tight junction; hsa05165 Human papillomavirus infection; hsa04730 Long-term depression; hsa04390 Hippo signaling pathway; hsa04151 PI3K-Akt signaling pathway; hsa04071 Sphingolipid signaling pathway; hsa03015 mRNA surveillance pathway; hsa04152 AMPK signaling pathway; hsa04728 Dopaminergic synapse; hsa04114 Oocyte meiosis","GO:0000086 G2/M transition of mitotic cell cycle; GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0001558 regulation of cell growth; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006275 regulation of DNA replication; GO:0006355 regulation of transcription"," DNA-templated; GO:0006396 RNA processing; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006464 cellular protein modification process; GO:0006469 negative regulation of protein kinase activity; GO:0006470 protein dephosphorylation; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006665 sphingolipid metabolic process; GO:0006672 ceramide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006914 autophagy; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007059 chromosome segregation; GO:0007098 centrosome cycle; GO:0007099 centriole replication; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008380 RNA splicing; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010921 regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016311 dephosphorylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019538 protein metabolic process; GO:0019932 second-messenger-mediated signaling; GO:0022402 cell cycle process; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030111 regulation of Wnt signaling pathway; GO:0030155 regulation of cell adhesion; GO:0030308 negative regulation of cell growth; GO:0031023 microtubule organizing center organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033673 negative regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035330 regulation of hippo signaling; GO:0035331 negative regulation of hippo signaling; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042509 regulation of tyrosine phosphorylation of STAT protein; GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043603 cellular amide metabolic process; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044782 cilium organization; GO:0044839 cell cycle G2/M phase transition; GO:0045595 regulation of cell differentiation; GO:0045859 regulation of protein kinase activity; GO:0045926 negative regulation of growth; GO:0045936 negative regulation of phosphate metabolic process; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT; GO:0046483 heterocycle metabolic process; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0046700 heterocycle catabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051298 centrosome duplication; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060271 cilium assembly; GO:0060561 apoptotic process involved in morphogenesis; GO:0061919 process utilizing autophagic mechanism; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097711 ciliary basal body-plasma membrane docking; GO:0098534 centriole assembly; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0140056 organelle localization by membrane tethering; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902742 apoptotic process involved in development; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1904892 regulation of receptor signaling pathway via STAT; GO:1904893 negative regulation of receptor signaling pathway via STAT; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001238 positive regulation of extrinsic apoptotic signaling pathway; GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand; GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;","GO:0000159 protein phosphatase type 2A complex; GO:0000775 chromosome"," centromeric region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005813 centrosome; GO:0005814 centriole; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0008287 protein serine/threonine phosphatase complex; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043186 P granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045121 membrane raft; GO:0045495 pole plasm; GO:0060293 germ plasm; GO:0072686 mitotic spindle; GO:0098687 chromosomal region; GO:0098857 membrane microdomain; GO:1902494 catalytic complex; GO:1903293 phosphatase complex; GO:1990904 ribonucleoprotein complex;","GO:0003823 antigen binding; GO:0005488 binding; GO:0005515 protein binding; GO:0017151 DEAD/H-box RNA helicase binding; GO:0019208 phosphatase regulator activity; GO:0019888 protein phosphatase regulator activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0098772 molecular function regulator; GO:1990405 protein antigen binding;",null,null,"T","KOG0211","Protein phosphatase 2A regulatory subunit A and related proteins","WP5117 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP500 GLYCOGEN SYNTHESIS AND DEGRADATION;WP4747 NETRINUNC5B SIGNALING PATHWAY;WP4172 PI3KAKT SIGNALING PATHWAY;WP399 WNT SIGNALING PATHWAY AND PLURIPOTENCY","http://www.wikipathways.org/instance/WP5117_r119395;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP500_r119104;http://www.wikipathways.org/instance/WP4747_r116543;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP399_r119242",null,"R-HSA-109582 Hemostasis;R-HSA-111885 Opioid Signalling;R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1;R-HSA-113510 E2F mediated regulation of DNA replication;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-1430728 Metabolism;R-HSA-162582 Signal Transduction;R-HSA-163685 Integration of energy metabolism;R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-166520 Signaling by NTRKs;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-180024 DARPP-32 events;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-187037 Signaling by NTRK1 (TRKA);R-HSA-194315 Signaling by Rho GTPases;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195258 RHO GTPase Effectors;R-HSA-195721 Signaling by WNT;R-HSA-196299 Beta-catenin phosphorylation cascade;R-HSA-198725 Nuclear Events (kinase and transcription factor activation);R-HSA-198753 ERK/MAPK targets;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202670 ERKs are inactivated;R-HSA-212436 Generic Transcription Pathway;R-HSA-2465910 MASTL Facilitates Mitotic Progression;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-388841 Costimulation by the CD28 family;R-HSA-389513 CTLA4 inhibitory signaling;R-HSA-418346 Platelet homeostasis;R-HSA-418594 G alpha (i) signalling events;R-HSA-432142 Platelet sensitization by LDL;R-HSA-448424 Interleukin-17 signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases;R-HSA-450294 MAP kinase activation;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane;R-HSA-4791275 Signaling by WNT in cancer;R-HSA-4839735 Signaling by AXIN mutants;R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants;R-HSA-4839744 Signaling by APC mutants;R-HSA-4839748 Signaling by AMER1 mutants;R-HSA-5339716 Signaling by GSK3beta mutants;R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated;R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated;R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated;R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated;R-HSA-5467337 APC truncation mutants have impaired AXIN binding;R-HSA-5467340 AXIN missense mutants destabilize the destruction complex;R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-5673000 RAF activation;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5675221 Negative regulation of MAPK pathway;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6804757 Regulation of TP53 Degradation;R-HSA-6806003 Regulation of TP53 Expression and Degradation;R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-68875 Mitotic Prophase;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69206 G1/S Transition;R-HSA-69231 Cyclin D associated events in G1;R-HSA-69236 G1 Phase;R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-70171 Glycolysis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-9634600 Regulation of glycolysis by fructose 2","6-bisphosphate metabolism;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-975871 MyD88 cascade initiated on plasma membrane",null,"PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["P30876","DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1","POLR2B",1.112629628,0.020895389,"nochange",37806.4,38954,35937.3,40783.5,43161.4,41445.9,0.952748243,0.981668581,0.90564559,1.027773286,1.087698062,1.044466238,"cytoplasm","K03010","RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]","hsa05016 Huntington disease; hsa03020 RNA polymerase","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006354 DNA-templated transcription"," elongation; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0008543 fibroblast growth factor receptor signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009301 snRNA transcription; GO:0009452 7-methylguanosine RNA capping; GO:0009719 response to endogenous stimulus; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016073 snRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023052 signaling; GO:0032774 RNA biosynthetic process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0036260 RNA capping; GO:0042221 response to chemical; GO:0042795 snRNA transcription by RNA polymerase II; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060964 regulation of gene silencing by miRNA; GO:0060966 regulation of gene silencing by RNA; GO:0065007 biological regulation; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071774 response to fibroblast growth factor; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098781 ncRNA transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005665 RNA polymerase II"," core complex; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003824 catalytic activity; GO:0003899 DNA-directed 5'-3' RNA polymerase activity; GO:0005488 binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0034062 5'-3' RNA polymerase activity; GO:0097159 organic cyclic compound binding; GO:0097747 RNA polymerase activity; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF04561; PF04565; PF04566; PF04567; PF00562; PF04560","PF04561 RNA polymerase Rpb2"," domain 2; PF04565 RNA polymerase Rpb2"," domain 3; PF04566 RNA polymerase Rpb2"," domain 4; PF04567 RNA polymerase Rpb2"," domain 5; PF00562 RNA polymerase Rpb2"," domain 6; PF04560 RNA polymerase Rpb2"," domain 7","K","KOG0214","RNA polymerase II"," second largest subunit","WP405 EUKARYOTIC TRANSCRIPTION INITIATION;WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP405_r118377;http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-113418 Formation of the Early Elongation Complex;R-HSA-1226099 Signaling by FGFR in disease;R-HSA-1266738 Developmental Biology;R-HSA-157579 Telomere Maintenance;R-HSA-162582 Signal Transduction;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167158 Formation of the HIV-1 Early Elongation Complex;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167161 HIV Transcription Initiation;R-HSA-167162 RNA Polymerase II HIV Promoter Escape;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation;R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat;R-HSA-167243 Tat-mediated HIV elongation arrest and recovery;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-167287 HIV elongation arrest and recovery;R-HSA-167290 Pausing and recovery of HIV elongation;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-168325 Viral Messenger RNA Synthesis;R-HSA-1839126 FGFR2 mutant receptor activation;R-HSA-190236 Signaling by FGFR;R-HSA-203927 MicroRNA (miRNA) biogenesis;R-HSA-211000 Gene Silencing by RNA;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-5654738 Signaling by FGFR2;R-HSA-5655253 Signaling by FGFR2 in disease;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6803529 FGFR2 alternative splicing;R-HSA-6807505 RNA polymerase II transcribes snRNA genes;R-HSA-72086 mRNA Capping;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72165 mRNA Splicing - Minor Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73776 RNA Polymerase II Promoter Escape;R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73886 Chromosome Maintenance;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-75953 RNA Polymerase II Transcription Initiation;R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance;R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8851708 Signaling by FGFR2 IIIa TM;R-HSA-8939211 ESR-mediated signaling;R-HSA-8953854 Metabolism of RNA;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9018519 Estrogen-dependent gene expression;R-HSA-9670095 Inhibition of DNA recombination at telomere"]
["P31321","cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4","PRKAR1B",0.689087297,0.03048385,"nochange",9831.42,8542.32,7383.49,6862.92,5388.77,5497.29,1.35586437,1.178082853,1.018267047,0.946474538,0.743172526,0.758138666,"cytoplasm","K04739","PRKAR; cAMP-dependent protein kinase regulator","hsa04910 Insulin signaling pathway","GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0003008 system process; GO:0003014 renal system process; GO:0003091 renal water homeostasis; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007610 behavior; GO:0007611 learning or memory; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009887 animal organ morphogenesis; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0016310 phosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0030104 water homeostasis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032870 cellular response to hormone stimulus; GO:0033673 negative regulation of kinase activity; GO:0033674 positive regulation of kinase activity; GO:0033762 response to glucagon; GO:0034199 activation of protein kinase A activity; GO:0036211 protein modification process; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048871 multicellular organismal homeostasis; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050877 nervous system process; GO:0050878 regulation of body fluid levels; GO:0050890 cognition; GO:0050891 multicellular organismal water homeostasis; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071377 cellular response to glucagon stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:2000479 regulation of cAMP-dependent protein kinase activity; GO:2000480 negative regulation of cAMP-dependent protein kinase activity;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005929 cilium; GO:0005952 cAMP-dependent protein kinase complex; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0097546 ciliary base; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0004857 enzyme inhibitor activity; GO:0004860 protein kinase inhibitor activity; GO:0004862 cAMP-dependent protein kinase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008603 cAMP-dependent protein kinase regulator activity; GO:0017076 purine nucleotide binding; GO:0019207 kinase regulator activity; GO:0019210 kinase inhibitor activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0030291 protein serine/threonine kinase inhibitor activity; GO:0030551 cyclic nucleotide binding; GO:0030552 cAMP binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0034236 protein kinase A catalytic subunit binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0051018 protein kinase A binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0098772 molecular function regulator; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF02197; PF00027","PF02197 Regulatory subunit of type II PKA R-subunit; PF00027 Cyclic nucleotide-binding domain","T","KOG1113","cAMP-dependent protein kinase types I and II"," regulatory subunit","WP536 CALCIUM REGULATION IN CARDIAC CELLS;WP3869 CANNABINOID RECEPTOR SIGNALING;WP35 G PROTEIN SIGNALING PATHWAYS;WP4540 HIPPO SIGNALING REGULATION PATHWAYS;WP4541 HIPPOMERLIN SIGNALING DYSREGULATION;WP3965 LIPID METABOLISM PATHWAY;WP289 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS;WP706 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS","http://www.wikipathways.org/instance/WP536_r116854;http://www.wikipathways.org/instance/WP3869_r118463;http://www.wikipathways.org/instance/WP35_r117729;http://www.wikipathways.org/instance/WP4540_r120395;http://www.wikipathways.org/instance/WP4541_r116745;http://www.wikipathways.org/instance/WP3965_r117154;http://www.wikipathways.org/instance/WP289_r120734;http://www.wikipathways.org/instance/WP706_r117178",null,"R-HSA-109582 Hemostasis;R-HSA-111885 Opioid Signalling;R-HSA-111931 PKA-mediated phosphorylation of CREB;R-HSA-111933 Calmodulin induced events;R-HSA-111996 Ca-dependent events;R-HSA-111997 CaM pathway;R-HSA-112040 G-protein mediated events;R-HSA-112043 PLC beta mediated events;R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission;R-HSA-112315 Transmission across Chemical Synapses;R-HSA-112316 Neuronal System;R-HSA-1430728 Metabolism;R-HSA-1489509 DAG and IP3 signaling;R-HSA-162582 Signal Transduction;R-HSA-163359 Glucagon signaling in metabolic regulation;R-HSA-163615 PKA activation;R-HSA-163685 Integration of energy metabolism;R-HSA-1643685 Disease;R-HSA-164378 PKA activation in glucagon signalling;R-HSA-180024 DARPP-32 events;R-HSA-372790 Signaling by GPCR;R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;R-HSA-382551 Transport of small molecules;R-HSA-388396 GPCR downstream signalling;R-HSA-418555 G alpha (s) signalling events;R-HSA-418594 G alpha (i) signalling events;R-HSA-422356 Regulation of insulin secretion;R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins;R-HSA-438064 Post NMDA receptor activation events;R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase;R-HSA-442755 Activation of NMDA receptors and postsynaptic events;R-HSA-445717 Aquaporin-mediated transport;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5663205 Infectious disease;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9634597 GPER1 signaling;R-HSA-9658195 Leishmania infection;R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production;R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection;R-HSA-9664323 FCGR3A-mediated IL10 synthesis;R-HSA-9664433 Leishmania parasite growth and survival;R-HSA-983231 Factors involved in megakaryocyte development and platelet production"]
["P32019","Type II inositol 1",4,"5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4","INPP5B",1.104896345,0.022103803,"nochange",17483,17557.9,16254.5,18673.2,18669.6,19333.3,0.971534155,0.975696364,0.90326614,1.037673831,1.037473778,1.074355733,"cytoplasm","K01099","INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000278 mitotic cell cycle; GO:0000281 mitotic cytokinesis; GO:0000910 cytokinesis; GO:0001701 in utero embryonic development; GO:0006066 alcohol metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0008152 metabolic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010564 regulation of cell cycle process; GO:0010646 regulation of cell communication; GO:0016192 vesicle-mediated transport; GO:0016311 dephosphorylation; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019751 polyol metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0030162 regulation of proteolysis; GO:0030258 lipid modification; GO:0030317 flagellated sperm motility; GO:0032187 actomyosin contractile ring localization; GO:0032465 regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032506 cytokinetic process; GO:0032954 regulation of cytokinetic process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0036214 contractile ring localization; GO:0040011 locomotion; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0043647 inositol phosphate metabolic process; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046839 phospholipid dephosphorylation; GO:0046856 phosphatidylinositol dephosphorylation; GO:0048232 male gamete generation; GO:0048583 regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051301 cell division; GO:0051302 regulation of cell division; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070613 regulation of protein processing; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0097722 sperm motility; GO:0098657 import into cell; GO:0110020 regulation of actomyosin structure organization; GO:1901615 organic hydroxy compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1903047 mitotic cell cycle process; GO:1903317 regulation of protein maturation; GO:2000431 regulation of cytokinesis"," actomyosin contractile ring assembly;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0055037 recycling endosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle;","GO:0003824 catalytic activity; GO:0004439 phosphatidylinositol-4","5-bisphosphate 5-phosphatase activity; GO:0004445 inositol-polyphosphate 5-phosphatase activity; GO:0005096 GTPase activator activity; GO:0008047 enzyme activator activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0034593 phosphatidylinositol bisphosphate phosphatase activity; GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0046030 inositol trisphosphate phosphatase activity; GO:0052658 inositol-1",4,"5-trisphosphate 5-phosphatase activity; GO:0052659 inositol-1",3,4,"5-tetrakisphosphate 5-phosphatase activity; GO:0052743 inositol tetrakisphosphate phosphatase activity; GO:0052745 inositol phosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator; GO:0106019 phosphatidylinositol-4","5-bisphosphate phosphatase activity;","PF16776; PF03372; PF00620","PF16776 Type II inositol 1",4,"5-trisphosphate 5-phosphatase PH domain; PF03372 Endonuclease/Exonuclease/phosphatase family; PF00620 RhoGAP domain","T","KOG4270","GTPase-activator protein",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483249 Inositol phosphate metabolism;R-HSA-1855183 Synthesis of IP2"," IP"," and Ins in the cytosol;R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483249;https://reactome.org/PathwayBrowser/#/R-HSA-1855183;https://reactome.org/PathwayBrowser/#/R-HSA-1855204"]
["P32780","General transcription factor IIH subunit 1 OS=Homo sapiens OX=9606 GN=GTF2H1 PE=1 SV=1","GTF2H1",0.510292808,{"v":3.52001e-05,"d":"3.52E-05"},"down",7792.5,7639.3,7189.82,3814.12,3714.91,4014.62,1.368494966,1.341590451,1.262654151,0.669824064,0.652401108,0.705035259,"nucleus","K03141","TFIIH1; transcription initiation factor TFIIH subunit 1","hsa03022 Basal transcription factors; hsa05203 Viral carcinogenesis; hsa03420 Nucleotide excision repair","GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0001109 promoter clearance during DNA-templated transcription; GO:0001111 promoter clearance from RNA polymerase II promoter; GO:0001112 DNA-templated transcription open complex formation; GO:0001113 transcription open complex formation at RNA polymerase II promoter; GO:0001120 protein-DNA complex remodeling; GO:0001932 regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006293 nucleotide-excision repair"," preincision complex stabilization; GO:0006294 nucleotide-excision repair"," preincision complex assembly; GO:0006296 nucleotide-excision repair"," DNA incision"," 5'-to lesion; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006353 DNA-templated transcription"," termination; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006360 transcription by RNA polymerase I; GO:0006361 transcription initiation from RNA polymerase I promoter; GO:0006363 termination of RNA polymerase I transcription; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009452 7-methylguanosine RNA capping; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032774 RNA biosynthetic process; GO:0033554 cellular response to stress; GO:0033683 nucleotide-excision repair"," DNA incision; GO:0034097 response to cytokine; GO:0034367 protein-containing complex remodeling; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0036260 RNA capping; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045859 regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070816 phosphorylation of RNA polymerase II C-terminal domain; GO:0070887 cellular response to chemical stimulus; GO:0070911 global genome nucleotide-excision repair; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0000439 transcription factor TFIIH core complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005675 transcription factor TFIIH holo complex; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032806 carboxy-terminal domain protein kinase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0003682 chromatin binding; GO:0005488 binding;","PF08567; PF03909","PF08567 TFIIH p62 subunit"," N-terminal domain; PF03909 BSD domain  ","KL","KOG2074","RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH"," subunit TFB1","WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP405 EUKARYOTIC TRANSCRIPTION INITIATION;WP4753 NUCLEOTIDE EXCISION REPAIR;WP5114 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM","http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP405_r118377;http://www.wikipathways.org/instance/WP4753_r119238;http://www.wikipathways.org/instance/WP5114_r119169",null,"R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-113418 Formation of the Early Elongation Complex;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167158 Formation of the HIV-1 Early Elongation Complex;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167161 HIV Transcription Initiation;R-HSA-167162 RNA Polymerase II HIV Promoter Escape;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-5663205 Infectious disease;R-HSA-5696395 Formation of Incision Complex in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-5696400 Dual Incision in GG-NER;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-72086 mRNA Capping;R-HSA-73762 RNA Polymerase I Transcription Initiation;R-HSA-73772 RNA Polymerase I Promoter Escape;R-HSA-73776 RNA Polymerase II Promoter Escape;R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;R-HSA-73854 RNA Polymerase I Promoter Clearance;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73863 RNA Polymerase I Transcription Termination;R-HSA-73864 RNA Polymerase I Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-75953 RNA Polymerase II Transcription Initiation;R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance;R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8953854 Metabolism of RNA",null,"DNA REPAIR;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["P34913","Bifunctional epoxide hydrolase 2 OS=Homo sapiens OX=9606 GN=EPHX2 PE=1 SV=2","EPHX2",0.912981811,0.115791298,"nochange",6659.75,7096.29,7740.96,6611.14,6591.63,6423.6,0.971673771,1.035366022,1.129424947,0.964581453,0.961734897,0.93721891,"endoplasmic reticulum","K08726","EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]","hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa00590 Arachidonic acid metabolism; hsa04146 Peroxisome; hsa05207 Chemical carcinogenesis - receptor activation; hsa01100 Metabolic pathways","GO:0001676 long-chain fatty acid metabolic process; GO:0002532 production of molecular mediator involved in inflammatory response; GO:0002538 arachidonic acid metabolite production involved in inflammatory response; GO:0002539 prostaglandin production involved in inflammatory response; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0006082 organic acid metabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006690 icosanoid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006810 transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0007600 sensory perception; GO:0008015 blood circulation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008217 regulation of blood pressure; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009410 response to xenobiotic stimulus; GO:0009636 response to toxic substance; GO:0009810 stilbene metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0016311 dephosphorylation; GO:0018904 ether metabolic process; GO:0019216 regulation of lipid metabolic process; GO:0019218 regulation of steroid metabolic process; GO:0019222 regulation of metabolic process; GO:0019233 sensory perception of pain; GO:0019369 arachidonic acid metabolic process; GO:0019373 epoxygenase P450 pathway; GO:0019439 aromatic compound catabolic process; GO:0019725 cellular homeostasis; GO:0019752 carboxylic acid metabolic process; GO:0030003 cellular cation homeostasis; GO:0030258 lipid modification; GO:0032501 multicellular organismal process; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033559 unsaturated fatty acid metabolic process; GO:0034613 cellular protein localization; GO:0035150 regulation of tube size; GO:0035296 regulation of tube diameter; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0042632 cholesterol homeostasis; GO:0042759 long-chain fatty acid biosynthetic process; GO:0042886 amide transport; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0043651 linoleic acid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045184 establishment of protein localization; GO:0045777 positive regulation of blood pressure; GO:0046272 stilbene catabolic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046839 phospholipid dephosphorylation; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050801 ion homeostasis; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055088 lipid homeostasis; GO:0055092 sterol homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0062012 regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071466 cellular response to xenobiotic stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0072593 reactive oxygen species metabolic process; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090181 regulation of cholesterol metabolic process; GO:0097176 epoxide metabolic process; GO:0097746 blood vessel diameter maintenance; GO:0098771 inorganic ion homeostasis; GO:1900673 olefin metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901568 fatty acid derivative metabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005782 peroxisomal matrix; GO:0005829 cytosol; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004301 epoxide hydrolase activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0015643 toxic substance binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0016801 hydrolase activity"," acting on ether bonds; GO:0016803 ether hydrolase activity; GO:0042577 lipid phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046983 protein dimerization activity;","PF00561","PF00561 alpha/beta hydrolase fold","I","KOG4178","Soluble epoxide hydrolase","WP5064 7OXOC AND 7BETAHC PATHWAYS;WP678 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE;WP4720 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY;WP5109 FAMILIAL HYPERLIPIDEMIA TYPE 2;WP702 METAPATHWAY BIOTRANSFORMATION PHASE I AND II;WP4545 OXYSTEROLS DERIVED FROM CHOLESTEROL","http://www.wikipathways.org/instance/WP5064_r120384;http://www.wikipathways.org/instance/WP678_r116938;http://www.wikipathways.org/instance/WP4720_r120365;http://www.wikipathways.org/instance/WP5109_r120391;http://www.wikipathways.org/instance/WP702_r106643;http://www.wikipathways.org/instance/WP4545_r120411",null,"R-HSA-1430728 Metabolism;R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET);R-HSA-2142753 Arachidonic acid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism;R-HSA-9018677 Biosynthesis of DHA-derived SPMs;R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs);R-HSA-9018682 Biosynthesis of maresins;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-2142670;https://reactome.org/PathwayBrowser/#/R-HSA-2142753;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9018677;https://reactome.org/PathwayBrowser/#/R-HSA-9018678;https://reactome.org/PathwayBrowser/#/R-HSA-9018682;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","ADIPOGENESIS;BILE ACID METABOLISM;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["P35244","Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1","RPA3",1.06861852,0.350985523,"nochange",41330.9,38279.3,37075.5,38892.6,45961.6,39838.3,1.027372812,0.951518406,0.921595239,0.966763361,1.142479313,0.99027087,"cytoskeleton","K10740","RPA3; replication factor A3","hsa03030 DNA replication; hsa03460 Fanconi anemia pathway; hsa03440 Homologous recombination; hsa03420 Nucleotide excision repair; hsa03430 Mismatch repair","GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000731 DNA synthesis involved in DNA repair; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006284 base-excision repair; GO:0006289 nucleotide-excision repair; GO:0006293 nucleotide-excision repair"," preincision complex stabilization; GO:0006294 nucleotide-excision repair"," preincision complex assembly; GO:0006296 nucleotide-excision repair"," DNA incision"," 5'-to lesion; GO:0006297 nucleotide-excision repair"," DNA gap filling; GO:0006298 mismatch repair; GO:0006301 postreplication repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019725 cellular homeostasis; GO:0019985 translesion synthesis; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032200 telomere organization; GO:0032201 telomere maintenance via semi-conservative replication; GO:0033260 nuclear DNA replication; GO:0033554 cellular response to stress; GO:0033683 nucleotide-excision repair"," DNA incision; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036297 interstrand cross-link repair; GO:0042127 regulation of cell population proliferation; GO:0042276 error-prone translesion synthesis; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044786 cell cycle DNA replication; GO:0044843 cell cycle G1/S phase transition; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051276 chromosome organization; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060249 anatomical structure homeostasis; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070987 error-free translesion synthesis; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:1900034 regulation of cellular response to heat; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903047 mitotic cell cycle process;","GO:0000228 nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005662 DNA replication factor A complex; GO:0005694 chromosome; GO:0030894 replisome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043596 nuclear replication fork; GO:0043601 nuclear replisome; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0003697 single-stranded DNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF08661","PF08661 Replication factor A protein 3",{"$nulls":3},"WP531 DNA MISMATCH REPAIR;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP466 DNA REPLICATION;WP45 G1 TO S CELL CYCLE CONTROL;WP4753 NUCLEOTIDE EXCISION REPAIR;WP5114 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM;WP2446 RETINOBLASTOMA GENE IN CANCER","http://www.wikipathways.org/instance/WP531_r117702;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP466_r117096;http://www.wikipathways.org/instance/WP45_r106424;http://www.wikipathways.org/instance/WP4753_r119238;http://www.wikipathways.org/instance/WP5114_r119169;http://www.wikipathways.org/instance/WP2446_r116593",null,"R-HSA-110312 Translesion synthesis by REV1;R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template;R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex;R-HSA-110320 Translesion Synthesis by POLH;R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway;R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-174414 Processive synthesis on the C-strand of the telomere;R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis;R-HSA-174437 Removal of the Flap Intermediate from the C-strand;R-HSA-176187 Activation of ATR in response to replication stress;R-HSA-180786 Extension of Telomeres;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-3371453 Regulation of HSF1-mediated heat shock response;R-HSA-3371511 HSF1 activation;R-HSA-3371556 Cellular response to heat stress;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-5358508 Mismatch Repair;R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair;R-HSA-5655862 Translesion synthesis by POLK;R-HSA-5656121 Translesion synthesis by POLI;R-HSA-5656169 Termination of translesion DNA synthesis;R-HSA-5685938 HDR through Single Strand Annealing (SSA);R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-5696395 Formation of Incision Complex in GG-NER;R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-5696400 Dual Incision in GG-NER;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-6783310 Fanconi Anemia Pathway;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-68962 Activation of the pre-replicative complex;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69166 Removal of the Flap Intermediate;R-HSA-69183 Processive synthesis on the lagging strand;R-HSA-69186 Lagging Strand Synthesis;R-HSA-69190 DNA strand elongation;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73884 Base Excision Repair;R-HSA-73886 Chromosome Maintenance;R-HSA-73893 DNA Damage Bypass;R-HSA-73894 DNA Repair;R-HSA-73933 Resolution of Abasic Sites (AP sites);R-HSA-74160 Gene expression (Transcription);R-HSA-8953897 Cellular responses to stimuli;R-HSA-912446 Meiotic recombination;R-HSA-9675135 Diseases of DNA repair;R-HSA-9675136 Diseases of DNA Double-Strand Break Repair;R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function;R-HSA-9709570 Impaired BRCA2 binding to RAD51",null,"DNA REPAIR;E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["P35475","Alpha-L-iduronidase OS=Homo sapiens OX=9606 GN=IDUA PE=1 SV=2","IDUA",1.047887259,0.591831932,"nochange",15821.1,15174.4,16390.8,18907.9,15197.5,15550.1,0.978203207,0.938218376,1.013427204,1.169057046,0.939646627,0.961447541,"extracellular","K01217","IDUA; L-iduronidase [EC:3.2.1.76]","hsa00531 Glycosaminoglycan degradation; hsa04142 Lysosome; hsa01100 Metabolic pathways","GO:0000902 cell morphogenesis; GO:0001501 skeletal system development; GO:0005975 carbohydrate metabolic process; GO:0005984 disaccharide metabolic process; GO:0006022 aminoglycan metabolic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006029 proteoglycan metabolic process; GO:0006082 organic acid metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007033 vacuole organization; GO:0007040 lysosome organization; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009311 oligosaccharide metabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0030203 glycosaminoglycan metabolic process; GO:0030204 chondroitin sulfate metabolic process; GO:0030205 dermatan sulfate metabolic process; GO:0030207 chondroitin sulfate catabolic process; GO:0030209 dermatan sulfate catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0032989 cellular component morphogenesis; GO:0035107 appendage morphogenesis; GO:0035108 limb morphogenesis; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044273 sulfur compound catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0048513 animal organ development; GO:0048705 skeletal system morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050654 chondroitin sulfate proteoglycan metabolic process; GO:0050655 dermatan sulfate proteoglycan metabolic process; GO:0060173 limb development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0080171 lytic vacuole organization; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1903510 mucopolysaccharide metabolic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0030135 coated vesicle; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle;","GO:0003824 catalytic activity; GO:0003940 L-iduronidase activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds;",{"$nulls":5},"WP4815 GLYCOSAMINOGLYCAN DEGRADATION","http://www.wikipathways.org/instance/WP4815_r110276",null,"R-HSA-1430728 Metabolism;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism;R-HSA-1643685 Disease;R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism;R-HSA-2024096 HS-GAG degradation;R-HSA-2024101 CS/DS degradation;R-HSA-2206281 Mucopolysaccharidoses;R-HSA-2206302 MPS I - Hurler syndrome;R-HSA-5663084 Diseases of carbohydrate metabolism;R-HSA-5668914 Diseases of metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-1638091;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1793185;https://reactome.org/PathwayBrowser/#/R-HSA-2024096;https://reactome.org/PathwayBrowser/#/R-HSA-2024101;https://reactome.org/PathwayBrowser/#/R-HSA-2206281;https://reactome.org/PathwayBrowser/#/R-HSA-2206302;https://reactome.org/PathwayBrowser/#/R-HSA-5663084;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-71387","GLYCOLYSIS;KRAS SIGNALING DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_DN"]
["P35754","Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2","GLRX",1.238589108,0.344204371,"nochange",1910.08,3343.42,4132.05,3771.41,4406.15,3447.28,0.545467266,0.954790463,1.180001894,1.077012849,1.258277452,0.984450074,"cytoplasm","K03676",null,null,"GO:0000003 reproduction; GO:0001678 cellular glucose homeostasis; GO:0002028 regulation of sodium ion transport; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0002931 response to ischemia; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007568 aging; GO:0008152 metabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway; GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010765 positive regulation of sodium ion transport; GO:0010817 regulation of hormone levels; GO:0010941 regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0014070 response to organic cyclic compound; GO:0015949 nucleobase-containing small molecule interconversion; GO:0017157 regulation of exocytosis; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0022414 reproductive process; GO:0022602 ovulation cycle process; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0032024 positive regulation of insulin secretion; GO:0032355 response to estradiol; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033500 carbohydrate homeostasis; GO:0033993 response to lipid; GO:0034284 response to monosaccharide; GO:0034641 cellular nitrogen compound metabolic process; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0042391 regulation of membrane potential; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042698 ovulation cycle; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043412 macromolecule modification; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0045838 positive regulation of membrane potential; GO:0045921 positive regulation of exocytosis; GO:0046483 heterocycle metabolic process; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0048511 rhythmic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048878 chemical homeostasis; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051716 cellular response to stimulus; GO:0055082 cellular chemical homeostasis; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060353 regulation of cell adhesion molecule production; GO:0060355 positive regulation of cell adhesion molecule production; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071326 cellular response to monosaccharide stimulus; GO:0071331 cellular response to hexose stimulus; GO:0071333 cellular response to glucose stimulus; GO:0071392 cellular response to estradiol stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0080058 protein deglutathionylation; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:1900407 regulation of cellular response to oxidative stress; GO:1900408 negative regulation of cellular response to oxidative stress; GO:1901031 regulation of response to reactive oxygen species; GO:1901032 negative regulation of response to reactive oxygen species; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901224 positive regulation of NIK/NF-kappaB signaling; GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death; GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902305 regulation of sodium ion transmembrane transport; GO:1902307 positive regulation of sodium ion transmembrane transport; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902882 regulation of response to oxidative stress; GO:1902883 negative regulation of response to oxidative stress; GO:1903201 regulation of oxidative stress-induced cell death; GO:1903202 negative regulation of oxidative stress-induced cell death; GO:1903205 regulation of hydrogen peroxide-induced cell death; GO:1903206 negative regulation of hydrogen peroxide-induced cell death; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1904951 positive regulation of establishment of protein localization; GO:2000586 regulation of platelet-derived growth factor receptor-beta signaling pathway; GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2000651 positive regulation of sodium ion transmembrane transporter activity; GO:2001023 regulation of response to drug; GO:2001024 negative regulation of response to drug; GO:2001038 regulation of cellular response to drug; GO:2001039 negative regulation of cellular response to drug;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005758 mitochondrial intermembrane space; GO:0005829 cytosol; GO:0030425 dendrite; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0070013 intracellular organelle lumen; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0015035 protein-disulfide reductase activity; GO:0015036 disulfide oxidoreductase activity; GO:0015038 glutathione disulfide oxidoreductase activity; GO:0016491 oxidoreductase activity; GO:0016667 oxidoreductase activity"," acting on a sulfur group of donors; GO:0016671 oxidoreductase activity"," acting on a sulfur group of donors"," disulfide as acceptor; GO:0019153 protein-disulfide reductase (glutathione) activity; GO:0019899 enzyme binding; GO:0047485 protein N-terminus binding; GO:0051117 ATPase binding; GO:0097573 glutathione oxidoreductase activity;","PF00462","PF00462 Glutaredoxin","O","KOG1752","Glutaredoxin and related proteins","WP241 ONECARBON METABOLISM","http://www.wikipathways.org/instance/WP241_r116573",null,"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-499943 Interconversion of nucleotide di- and triphosphates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-499943","GLYCOLYSIS;HYPOXIA;KRAS SIGNALING UP;MTORC1 SIGNALING;REACTIVE OXYGEN SPECIES PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"]
["P36542","ATP synthase subunit gamma"," mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1","ATP5F1C",1.08972472,0.007436691,"nochange",181299,182475,185194,193225,201446,203553,0.94822314,0.95437381,0.968594621,1.010598052,1.053595213,1.064615165,"mitochondria","K02136","ATPeF1G; F-type H+-transporting ATPase subunit gamma","hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006754 ATP biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006839 mitochondrial transport; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007007 inner mitochondrial membrane organization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009142 nucleoside triphosphate biosynthetic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009145 purine nucleoside triphosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009201 ribonucleoside triphosphate biosynthetic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009206 purine ribonucleoside triphosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0015985 energy coupled proton transport"," down electrochemical gradient; GO:0015986 ATP synthesis coupled proton transport; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0034220 ion transmembrane transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042407 cristae formation; GO:0042776 mitochondrial ATP synthesis coupled proton transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046034 ATP metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061024 membrane organization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902600 proton transmembrane transport; GO:1990542 mitochondrial transmembrane transport;","GO:0000275 mitochondrial proton-transporting ATP synthase complex"," catalytic sector F(1); GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005753 mitochondrial proton-transporting ATP synthase complex; GO:0005759 mitochondrial matrix; GO:0016020 membrane; GO:0016469 proton-transporting two-sector ATPase complex; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0033178 proton-transporting two-sector ATPase complex"," catalytic domain; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045259 proton-transporting ATP synthase complex; GO:0045261 proton-transporting ATP synthase complex"," catalytic core F(1); GO:0070013 intracellular organelle lumen; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex;","GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0022857 transmembrane transporter activity;","PF00231","PF00231 ATP synthase","C","KOG1531","F0F1-type ATP synthase"," gamma subunit","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA","http://www.wikipathways.org/instance/WP111_r117097",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-1592230 Mitochondrial biogenesis;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-163210 Formation of ATP by chemiosmotic coupling;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-8949613 Cristae formation","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-163210;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-8949613","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P37802","Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3","TAGLN2",1.07584154,0.013949683,"nochange",323863,323600,309295,348936,341465,338919,0.97839964,0.977605109,0.934389284,1.05414591,1.031575799,1.023884258,"cytoplasm","nucleus","K20526",null,null,"GO:0002576 platelet degranulation; GO:0006810 transport; GO:0006887 exocytosis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0030154 cell differentiation; GO:0030855 epithelial cell differentiation; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0060429 epithelium development;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;",null,"PF00307","PF00307 Calponin homology (CH) domain","Z","KOG2046","Calponin",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005"]
["P38117","Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3","ETFB",1.130892612,0.023120052,"nochange",177805,176837,189514,207977,212548,194857,0.920047467,0.915038576,0.980635391,1.076171717,1.09982424,1.008282609,"cytoplasm","K03521",null,null,"GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007406 negative regulation of neuroblast proliferation; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010721 negative regulation of cell development; GO:0016042 lipid catabolic process; GO:0016054 organic acid catabolic process; GO:0016310 phosphorylation; GO:0019395 fatty acid oxidation; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022008 neurogenesis; GO:0022900 electron transport chain; GO:0030154 cell differentiation; GO:0030258 lipid modification; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; GO:0034440 lipid oxidation; GO:0034641 cellular nitrogen compound metabolic process; GO:0042127 regulation of cell population proliferation; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0046034 ATP metabolic process; GO:0046395 carboxylic acid catabolic process; GO:0046483 heterocycle metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072091 regulation of stem cell proliferation; GO:0072329 monocarboxylic acid catabolic process; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process; GO:1902692 regulation of neuroblast proliferation; GO:2000026 regulation of multicellular organismal development; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000647 negative regulation of stem cell proliferation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0017133 mitochondrial electron transfer flavoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045251 electron transfer flavoprotein complex; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity;","PF01012","PF01012 Electron transfer flavoprotein domain","C","KOG3180","Electron transfer flavoprotein"," beta subunit",{"$nulls":3},"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-611105 Respiratory electron transport;R-HSA-8876725 Protein methylation","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-611105;https://reactome.org/PathwayBrowser/#/R-HSA-8876725","ADIPOGENESIS;ESTROGEN RESPONSE LATE;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P39656","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Homo sapiens OX=9606 GN=DDOST PE=1 SV=4","DDOST",1.094355852,3.26816E-3,"nochange",182178,186092,187456,205856,204111,198195,0.939152221,0.95932942,0.966361024,1.061215512,1.052219801,1.021722021,"plasma membrane","K12670","WBP1; oligosaccharyltransferase complex subunit beta","hsa00510 N-Glycan biosynthesis; hsa00513 Various types of N-glycan biosynthesis; hsa04141 Protein processing in endoplasmic reticulum; hsa01100 Metabolic pathways","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006487 protein N-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010256 endomembrane system organization; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0018193 peptidyl-amino acid modification; GO:0018196 peptidyl-asparagine modification; GO:0018279 protein N-linked glycosylation via asparagine; GO:0019538 protein metabolic process; GO:0032940 secretion by cell; GO:0034097 response to cytokine; GO:0034389 lipid droplet organization; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0042110 T cell activation; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046649 lymphocyte activation; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0008250 oligosaccharyltransferase complex; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0035577 azurophil granule membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle; GO:1902494 catalytic complex; GO:1990234 transferase complex;",{"$nulls":3},"O","KOG2754","Oligosaccharyltransferase"," beta subunit","WP2324 AGERAGE PATHWAY","http://www.wikipathways.org/instance/WP2324_r120674",null,"R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-72766 Translation;R-HSA-879415 Advanced glycosylation endproduct receptor signaling;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694548 Maturation of spike protein;R-HSA-9694635 Translation of Structural Proteins;R-HSA-9772573 Late SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1799339;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-72766;https://reactome.org/PathwayBrowser/#/R-HSA-879415;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694548;https://reactome.org/PathwayBrowser/#/R-HSA-9694635;https://reactome.org/PathwayBrowser/#/R-HSA-9772573"]
["P40424","Pre-B-cell leukemia transcription factor 1 OS=Homo sapiens OX=9606 GN=PBX1 PE=1 SV=1","PBX1",1.149372377,0.442988456,"nochange",3255.51,4770.24,3157.71,3961.57,5229.55,3662.84,0.812610505,1.190703495,0.788198567,0.988850717,1.305352238,0.914284478,"nucleus","K09355","PBX1; pre-B-cell leukemia transcription factor 1","hsa04927 Cortisol synthesis and secretion; hsa04934 Cushing syndrome; hsa05202 Transcriptional misregulation in cancer","GO:0001501 skeletal system development; GO:0001654 eye development; GO:0001655 urogenital system development; GO:0001657 ureteric bud development; GO:0001658 branching involved in ureteric bud morphogenesis; GO:0001704 formation of primary germ layer; GO:0001707 mesoderm formation; GO:0001708 cell fate specification; GO:0001710 mesodermal cell fate commitment; GO:0001742 oenocyte differentiation; GO:0001763 morphogenesis of a branching structure; GO:0001822 kidney development; GO:0001823 mesonephros development; GO:0001837 epithelial to mesenchymal transition; GO:0002009 morphogenesis of an epithelium; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003002 regionalization; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006606 protein import into nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007221 positive regulation of transcription of Notch receptor target; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007369 gastrulation; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007422 peripheral nervous system development; GO:0007423 sensory organ development; GO:0007431 salivary gland development; GO:0007432 salivary gland boundary specification; GO:0007438 oenocyte development; GO:0007498 mesoderm development; GO:0007501 mesodermal cell fate specification; GO:0007525 somatic muscle development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009786 regulation of asymmetric cell division; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009952 anterior/posterior pattern specification; GO:0009954 proximal/distal pattern formation; GO:0009987 cellular process; GO:0010160 formation of animal organ boundary; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010453 regulation of cell fate commitment; GO:0010455 positive regulation of cell fate commitment; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010470 regulation of gastrulation; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010721 negative regulation of cell development; GO:0010971 positive regulation of G2/M transition of mitotic cell cycle; GO:0014029 neural crest formation; GO:0014033 neural crest cell differentiation; GO:0014034 neural crest cell fate commitment; GO:0014036 neural crest cell fate specification; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016070 RNA metabolic process; GO:0017038 protein import; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019827 stem cell population maintenance; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023052 signaling; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0030278 regulation of ossification; GO:0030325 adrenal gland development; GO:0030326 embryonic limb morphogenesis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035019 somatic stem cell population maintenance; GO:0035107 appendage morphogenesis; GO:0035108 limb morphogenesis; GO:0035113 embryonic appendage morphogenesis; GO:0035162 embryonic hemopoiesis; GO:0035239 tube morphogenesis; GO:0035270 endocrine system development; GO:0035272 exocrine system development; GO:0035295 tube development; GO:0040019 positive regulation of embryonic development; GO:0042127 regulation of cell population proliferation; GO:0042659 regulation of cell fate specification; GO:0042660 positive regulation of cell fate specification; GO:0042661 regulation of mesodermal cell fate specification; GO:0042692 muscle cell differentiation; GO:0042886 amide transport; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045165 cell fate commitment; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045787 positive regulation of cell cycle; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045995 regulation of embryonic development; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048332 mesoderm morphogenesis; GO:0048333 mesodermal cell differentiation; GO:0048337 positive regulation of mesodermal cell fate specification; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048536 spleen development; GO:0048538 thymus development; GO:0048568 embryonic organ development; GO:0048598 embryonic morphogenesis; GO:0048645 animal organ formation; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048706 embryonic skeletal system development; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048736 appendage development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048762 mesenchymal cell differentiation; GO:0048856 anatomical structure development; GO:0048859 formation of anatomical boundary; GO:0048863 stem cell differentiation; GO:0048865 stem cell fate commitment; GO:0048866 stem cell fate specification; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051302 regulation of cell division; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060173 limb development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060429 epithelium development; GO:0060485 mesenchyme development; GO:0060562 epithelial tube morphogenesis; GO:0060675 ureteric bud morphogenesis; GO:0060795 cell fate commitment involved in formation of primary germ layer; GO:0060993 kidney morphogenesis; GO:0061061 muscle structure development; GO:0061138 morphogenesis of a branching epithelium; GO:0061326 renal tubule development; GO:0061333 renal tubule morphogenesis; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072001 renal system development; GO:0072006 nephron development; GO:0072009 nephron epithelium development; GO:0072028 nephron morphogenesis; GO:0072073 kidney epithelium development; GO:0072078 nephron tubule morphogenesis; GO:0072080 nephron tubule development; GO:0072088 nephron epithelium morphogenesis; GO:0072163 mesonephric epithelium development; GO:0072164 mesonephric tubule development; GO:0072171 mesonephric tubule morphogenesis; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902751 positive regulation of cell cycle G2/M phase transition; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905770 regulation of mesodermal cell differentiation; GO:1905772 positive regulation of mesodermal cell differentiation; GO:1905902 regulation of mesoderm formation; GO:1905904 positive regulation of mesoderm formation; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000380 regulation of mesoderm development; GO:2000382 positive regulation of mesoderm development; GO:2000543 positive regulation of gastrulation; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001221 transcription coregulator binding; GO:0001223 transcription coactivator binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0043565 sequence-specific DNA binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00046","PF00046 Homeodomain","K","KOG0774","Transcription factor PBX and related HOX domain proteins","WP5053 DEVELOPMENT OF URETERIC COLLECTION SYSTEM;WP2853 ENDODERM DIFFERENTIATION;WP4842 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT;WP2857 MESODERMAL COMMITMENT PATHWAY;WP3527 PREIMPLANTATION EMBRYO;WP706 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS","http://www.wikipathways.org/instance/WP5053_r118778;http://www.wikipathways.org/instance/WP2853_r116557;http://www.wikipathways.org/instance/WP4842_r119114;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP3527_r116646;http://www.wikipathways.org/instance/WP706_r117178","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-452723 Transcriptional regulation of pluripotent stem cells;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-9012852 Signaling by NOTCH3;R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-157118;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-452723;https://reactome.org/PathwayBrowser/#/R-HSA-5617472;https://reactome.org/PathwayBrowser/#/R-HSA-5619507;https://reactome.org/PathwayBrowser/#/R-HSA-9012852;https://reactome.org/PathwayBrowser/#/R-HSA-9013508"]
["P41212","Transcription factor ETV6 OS=Homo sapiens OX=9606 GN=ETV6 PE=1 SV=1","ETV6",1.388732965,6.14078E-4,"up",35681.2,36998.5,33960.6,48911.4,51500.2,47683.3,0.840430376,0.87145789,0.799903586,1.152052798,1.213029059,1.12312629,"nucleus","K03211","ETV6_7; ETS translocation variant 6/7","hsa05202 Transcriptional misregulation in cancer","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000165 MAPK cascade; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001709 cell fate determination; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001752 compound eye photoreceptor fate commitment; GO:0001754 eye photoreceptor cell differentiation; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0007028 cytoplasm organization; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007296 vitellogenesis; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007464 R3/R4 cell fate commitment; GO:0007548 sex differentiation; GO:0007568 aging; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008340 determination of adult lifespan; GO:0008406 gonad development; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009996 negative regulation of cell fate specification; GO:0010259 multicellular organism aging; GO:0010453 regulation of cell fate commitment; GO:0010454 negative regulation of cell fate commitment; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032774 RNA biosynthetic process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035155 negative regulation of terminal cell fate specification"," open tracheal system; GO:0035157 negative regulation of fusion cell fate specification; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0042051 compound eye photoreceptor development; GO:0042067 establishment of ommatidial planar polarity; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0042659 regulation of cell fate specification; GO:0042692 muscle cell differentiation; GO:0042706 eye photoreceptor cell fate commitment; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045137 development of primary sexual characteristics; GO:0045165 cell fate commitment; GO:0045466 R7 cell differentiation; GO:0045467 R7 cell development; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045610 regulation of hemocyte differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045676 regulation of R7 cell differentiation; GO:0045678 positive regulation of R7 cell differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0046532 regulation of photoreceptor cell differentiation; GO:0046533 negative regulation of photoreceptor cell differentiation; GO:0046534 positive regulation of photoreceptor cell differentiation; GO:0046552 photoreceptor cell fate commitment; GO:0046578 regulation of Ras protein signal transduction; GO:0046580 negative regulation of Ras protein signal transduction; GO:0048056 R3/R4 cell differentiation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048663 neuron fate commitment; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051058 negative regulation of small GTPase mediated signal transduction; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051403 stress-activated MAPK cascade; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0060232 delamination; GO:0060233 oenocyte delamination; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0061061 muscle structure development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0071425 hematopoietic stem cell proliferation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072089 stem cell proliferation; GO:0080090 regulation of primary metabolic process; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090175 regulation of establishment of planar polarity; GO:0090304 nucleic acid metabolic process; GO:0090596 sensory organ morphogenesis; GO:0097152 mesenchymal cell apoptotic process; GO:0097659 nucleic acid-templated transcription; GO:0098657 import into cell; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905330 regulation of morphogenesis of an epithelium; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000050 regulation of non-canonical Wnt signaling pathway; GO:2000051 negative regulation of non-canonical Wnt signaling pathway; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019904 protein domain specific binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF02198; PF00178","PF02198 Sterile alpha motif (SAM)/Pointed domain; PF00178 Ets-domain","K","KOG3804","Transcription factor NERF and related proteins"," contain ETS domain","WP410 EXERCISEINDUCED CIRCADIAN REGULATION;WP3657 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHABETA COMPLEX","http://www.wikipathways.org/instance/WP410_r117108;http://www.wikipathways.org/instance/WP3657_r120797","Transcription factor","R-HSA-1643685 Disease;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-9671555 Signaling by PDGFR in disease;R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB;R-HSA-9682385 FLT3 signaling in disease;R-HSA-9703465 Signaling by FLT3 fusion proteins","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-9671555;https://reactome.org/PathwayBrowser/#/R-HSA-9673768;https://reactome.org/PathwayBrowser/#/R-HSA-9682385;https://reactome.org/PathwayBrowser/#/R-HSA-9703465"]
["P42229","Signal transducer and activator of transcription 5A OS=Homo sapiens OX=9606 GN=STAT5A PE=1 SV=1","STAT5A",0.670606013,{"v":4.61326e-05,"d":"4.61E-05"},"down",155634,162899,154642,106337,103101,107876,1.181299171,1.236442253,1.173769654,0.807123186,0.782561174,0.818804563,"cytoplasm","K11223","STAT5A; signal transducer and activator of transcription 5A","hsa05161 Hepatitis B; hsa05203 Viral carcinogenesis; hsa05221 Acute myeloid leukemia; hsa05166 Human T-cell leukemia virus 1 infection; hsa05200 Pathways in cancer; hsa04935 Growth hormone synthesis"," secretion and action; hsa05207 Chemical carcinogenesis - receptor activation; hsa04917 Prolactin signaling pathway; hsa04012 ErbB signaling pathway; hsa04630 JAK-STAT signaling pathway; hsa05162 Measles; hsa04658 Th1 and Th2 cell differentiation; hsa05223 Non-small cell lung cancer; hsa04659 Th17 cell differentiation; hsa05220 Chronic myeloid leukemia; hsa04217 Necroptosis; hsa04933 AGE-RAGE signaling pathway in diabetic complications","GO:0000003 reproduction; GO:0000255 allantoin metabolic process; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001553 luteinization; GO:0001654 eye development; GO:0001655 urogenital system development; GO:0001667 ameboidal-type cell migration; GO:0001672 regulation of chromatin assembly or disassembly; GO:0001709 cell fate determination; GO:0001775 cell activation; GO:0001776 leukocyte homeostasis; GO:0001779 natural killer cell differentiation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001910 regulation of leukocyte mediated cytotoxicity; GO:0001912 positive regulation of leukocyte mediated cytotoxicity; GO:0001936 regulation of endothelial cell proliferation; GO:0001938 positive regulation of endothelial cell proliferation; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002230 positive regulation of defense response to virus by host; GO:0002237 response to molecule of bacterial origin; GO:0002260 lymphocyte homeostasis; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002703 regulation of leukocyte mediated immunity; GO:0002705 positive regulation of leukocyte mediated immunity; GO:0002706 regulation of lymphocyte mediated immunity; GO:0002708 positive regulation of lymphocyte mediated immunity; GO:0002715 regulation of natural killer cell mediated immunity; GO:0002717 positive regulation of natural killer cell mediated immunity; GO:0002759 regulation of antimicrobial humoral response; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0002763 positive regulation of myeloid leukocyte differentiation; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0002920 regulation of humoral immune response; GO:0002921 negative regulation of humoral immune response; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006082 organic acid metabolic process; GO:0006101 citrate metabolic process; GO:0006103 2-oxoglutarate metabolic process; GO:0006105 succinate metabolic process; GO:0006107 oxaloacetate metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006520 cellular amino acid metabolic process; GO:0006549 isoleucine metabolic process; GO:0006573 valine metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006600 creatine metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006805 xenobiotic metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007259 receptor signaling pathway via JAK-STAT; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007346 regulation of mitotic cell cycle; GO:0007350 blastoderm segmentation; GO:0007379 segment specification; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007425 epithelial cell fate determination"," open tracheal system; GO:0007442 hindgut morphogenesis; GO:0007444 imaginal disc development; GO:0007455 eye-antennal disc morphogenesis; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007525 somatic muscle development; GO:0007526 larval somatic muscle development; GO:0007530 sex determination; GO:0007538 primary sex determination; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007565 female pregnancy; GO:0007589 body fluid secretion; GO:0007595 lactation; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008348 negative regulation of antimicrobial humoral response; GO:0008406 gonad development; GO:0008585 female gonad development; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009081 branched-chain amino acid metabolic process; GO:0009314 response to radiation; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009880 embryonic pattern specification; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010165 response to X-ray; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010847 regulation of chromatin assembly; GO:0010876 lipid localization; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0016999 antibiotic metabolic process; GO:0017145 stem cell division; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019216 regulation of lipid metabolic process; GO:0019218 regulation of steroid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019530 taurine metabolic process; GO:0019538 protein metabolic process; GO:0019694 alkanesulfonate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019827 stem cell population maintenance; GO:0019915 lipid storage; GO:0019953 sexual reproduction; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022602 ovulation cycle process; GO:0022612 gland morphogenesis; GO:0023052 signaling; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030101 natural killer cell activation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030217 T cell differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030707 ovarian follicle cell development; GO:0030713 ovarian follicle cell stalk formation; GO:0030718 germ-line stem cell population maintenance; GO:0030720 oocyte localization involved in germarium-derived egg chamber formation; GO:0030850 prostate gland development; GO:0030855 epithelial cell differentiation; GO:0030856 regulation of epithelial cell differentiation; GO:0030879 mammary gland development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031341 regulation of cell killing; GO:0031343 positive regulation of cell killing; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031445 regulation of heterochromatin assembly; GO:0031453 positive regulation of heterochromatin assembly; GO:0031667 response to nutrient levels; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032355 response to estradiol; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032663 regulation of interleukin-2 production; GO:0032743 positive regulation of interleukin-2 production; GO:0032774 RNA biosynthetic process; GO:0032787 monocarboxylic acid metabolic process; GO:0032814 regulation of natural killer cell activation; GO:0032816 positive regulation of natural killer cell activation; GO:0032823 regulation of natural killer cell differentiation; GO:0032825 positive regulation of natural killer cell differentiation; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032944 regulation of mononuclear cell proliferation; GO:0032946 positive regulation of mononuclear cell proliferation; GO:0032989 cellular component morphogenesis; GO:0033025 regulation of mast cell apoptotic process; GO:0033026 negative regulation of mast cell apoptotic process; GO:0033032 regulation of myeloid cell apoptotic process; GO:0033033 negative regulation of myeloid cell apoptotic process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033077 T cell differentiation in thymus; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035019 somatic stem cell population maintenance; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035166 post-embryonic hemopoiesis; GO:0035167 larval lymph gland hemopoiesis; GO:0035168 larval lymph gland hemocyte differentiation; GO:0035171 lamellocyte differentiation; GO:0035172 hemocyte proliferation; GO:0035214 eye-antennal disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0035723 interleukin-15-mediated signaling pathway; GO:0036211 protein modification process; GO:0038110 interleukin-2-mediated signaling pathway; GO:0038111 interleukin-7-mediated signaling pathway; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040017 positive regulation of locomotion; GO:0040018 positive regulation of multicellular organism growth; GO:0040024 dauer larval development; GO:0042078 germ-line stem cell division; GO:0042102 positive regulation of T cell proliferation; GO:0042104 positive regulation of activated T cell proliferation; GO:0042110 T cell activation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042221 response to chemical; GO:0042269 regulation of natural killer cell mediated cytotoxicity; GO:0042386 hemocyte differentiation; GO:0042387 plasmatocyte differentiation; GO:0042592 homeostatic process; GO:0042698 ovulation cycle; GO:0042981 regulation of apoptotic process; GO:0043029 T cell homeostasis; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0043536 positive regulation of blood vessel endothelial cell migration; GO:0043603 cellular amide metabolic process; GO:0043648 dicarboxylic acid metabolic process; GO:0043696 dedifferentiation; GO:0043697 cell dedifferentiation; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045136 development of secondary sexual characteristics; GO:0045137 development of primary sexual characteristics; GO:0045165 cell fate commitment; GO:0045321 leukocyte activation; GO:0045471 response to ethanol; GO:0045577 regulation of B cell differentiation; GO:0045579 positive regulation of B cell differentiation; GO:0045580 regulation of T cell differentiation; GO:0045582 positive regulation of T cell differentiation; GO:0045586 regulation of gamma-delta T cell differentiation; GO:0045588 positive regulation of gamma-delta T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045621 positive regulation of lymphocyte differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045638 negative regulation of myeloid cell differentiation; GO:0045639 positive regulation of myeloid cell differentiation; GO:0045646 regulation of erythrocyte differentiation; GO:0045647 negative regulation of erythrocyte differentiation; GO:0045648 positive regulation of erythrocyte differentiation; GO:0045785 positive regulation of cell adhesion; GO:0045787 positive regulation of cell cycle; GO:0045799 positive regulation of chromatin assembly or disassembly; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045954 positive regulation of natural killer cell mediated cytotoxicity; GO:0046006 regulation of activated T cell proliferation; GO:0046449 creatinine metabolic process; GO:0046483 heterocycle metabolic process; GO:0046543 development of secondary female sexual characteristics; GO:0046544 development of secondary male sexual characteristics; GO:0046545 development of primary female sexual characteristics; GO:0046643 regulation of gamma-delta T cell activation; GO:0046645 positive regulation of gamma-delta T cell activation; GO:0046649 lymphocyte activation; GO:0046660 female sex differentiation; GO:0046661 male sex differentiation; GO:0046677 response to antibiotic; GO:0046903 secretion; GO:0048103 somatic stem cell division; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048511 rhythmic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048537 mucosa-associated lymphoid tissue development; GO:0048541 Peyer's patch development; GO:0048542 lymph gland development; GO:0048546 digestive tract morphogenesis; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048565 digestive tract development; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048771 tissue remodeling; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048872 homeostasis of number of cells; GO:0050670 regulation of lymphocyte proliferation; GO:0050671 positive regulation of lymphocyte proliferation; GO:0050678 regulation of epithelial cell proliferation; GO:0050679 positive regulation of epithelial cell proliferation; GO:0050688 regulation of defense response to virus; GO:0050691 regulation of defense response to virus by host; GO:0050727 regulation of inflammatory response; GO:0050729 positive regulation of inflammatory response; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050864 regulation of B cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050871 positive regulation of B cell activation; GO:0050877 nervous system process; GO:0050878 regulation of body fluid levels; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051301 cell division; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0055123 digestive system development; GO:0060056 mammary gland involution; GO:0060255 regulation of macromolecule metabolic process; GO:0060375 regulation of mast cell differentiation; GO:0060376 positive regulation of mast cell differentiation; GO:0060396 growth hormone receptor signaling pathway; GO:0060397 growth hormone receptor signaling pathway via JAK-STAT; GO:0060416 response to growth hormone; GO:0060429 epithelium development; GO:0060443 mammary gland morphogenesis; GO:0060512 prostate gland morphogenesis; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060740 prostate gland epithelium morphogenesis; GO:0060742 epithelial cell differentiation involved in prostate gland development; GO:0061061 muscle structure development; GO:0061180 mammary gland epithelium development; GO:0061458 reproductive system development; GO:0061525 hindgut development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070663 regulation of leukocyte proliferation; GO:0070665 positive regulation of leukocyte proliferation; GO:0070666 regulation of mast cell proliferation; GO:0070668 positive regulation of mast cell proliferation; GO:0070669 response to interleukin-2; GO:0070672 response to interleukin-15; GO:0070848 response to growth factor; GO:0070849 response to epidermal growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071350 cellular response to interleukin-15; GO:0071352 cellular response to interleukin-2; GO:0071363 cellular response to growth factor stimulus; GO:0071364 cellular response to epidermal growth factor stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071378 cellular response to growth hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071466 cellular response to xenobiotic stimulus; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071481 cellular response to X-ray; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072338 cellular lactam metabolic process; GO:0072350 tricarboxylic acid metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090304 nucleic acid metabolic process; GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus; GO:0097012 response to granulocyte macrophage colony-stimulating factor; GO:0097305 response to alcohol; GO:0097659 nucleic acid-templated transcription; GO:0097696 receptor signaling pathway via STAT; GO:0098727 maintenance of cell number; GO:0098760 response to interleukin-7; GO:0098761 cellular response to interleukin-7; GO:0104004 cellular response to environmental stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1902275 regulation of chromatin organization; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1905269 positive regulation of chromatin organization; GO:2000026 regulation of multicellular organismal development; GO:2000106 regulation of leukocyte apoptotic process; GO:2000107 negative regulation of leukocyte apoptotic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000736 regulation of stem cell differentiation; GO:2000737 negative regulation of stem cell differentiation; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0009898 cytoplasmic side of plasma membrane; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045177 apical part of cell; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098590 plasma membrane region; GO:0098592 cytoplasmic side of apical plasma membrane;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0035259 glucocorticoid receptor binding; GO:0042393 histone binding; GO:0043565 sequence-specific DNA binding; GO:0046983 protein dimerization activity; GO:0051427 hormone receptor binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF02865; PF02864; PF00017","PF02865 STAT protein"," protein interaction domain; PF02864 STAT protein"," DNA binding domain; PF00017 SH2 domain","KT","KOG3667","STAT protein","WP4906 3Q29 COPY NUMBER VARIATION SYNDROME;WP236 ADIPOGENESIS;WP2324 AGERAGE PATHWAY;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP437 EGFEGFR SIGNALING PATHWAY;WP581 EPO RECEPTOR SIGNALING;WP673 ERBB SIGNALING PATHWAY;WP5063 FOXP3 IN COVID19;WP2849 HEMATOPOIETIC STEM CELL DIFFERENTIATION;WP4666 HEPATITIS B INFECTION;WP49 IL2 SIGNALING PATHWAY;WP286 IL3 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP127 IL5 SIGNALING PATHWAY;WP205 IL7 SIGNALING PATHWAY;WP22 IL9 SIGNALING PATHWAY;WP585 INTERFERON TYPE I SIGNALING PATHWAYS;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP2814 MAMMARY GLAND DEVELOPMENT PATHWAY PUBERTY STAGE 2 OF 4;WP4630 MEASLES VIRUS INFECTION;WP4255 NONSMALL CELL LUNG CANCER;WP3972 PDGFRBETA PATHWAY;WP3680 PHYSICOCHEMICAL FEATURES AND TOXICITYASSOCIATED PATHWAYS;WP2037 PROLACTIN SIGNALING PATHWAY;WP3303 RAC1PAK1P38MMP2 PATHWAY;WP2203 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING PATHWAY;WP3945 TYROBP CAUSAL NETWORK IN MICROGLIA;WP4149 WHITE FAT CELL DIFFERENTIATION","http://www.wikipathways.org/instance/WP4906_r115773;http://www.wikipathways.org/instance/WP236_r105873;http://www.wikipathways.org/instance/WP2324_r120674;http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP581_r117099;http://www.wikipathways.org/instance/WP673_r118930;http://www.wikipathways.org/instance/WP5063_r118833;http://www.wikipathways.org/instance/WP2849_r117150;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP49_r120703;http://www.wikipathways.org/instance/WP286_r120663;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP127_r120669;http://www.wikipathways.org/instance/WP205_r120718;http://www.wikipathways.org/instance/WP22_r120719;http://www.wikipathways.org/instance/WP585_r107188;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP2814_r102407;http://www.wikipathways.org/instance/WP4630_r120771;http://www.wikipathways.org/instance/WP4255_r119279;http://www.wikipathways.org/instance/WP3972_r108157;http://www.wikipathways.org/instance/WP3680_r117651;http://www.wikipathways.org/instance/WP2037_r116779;http://www.wikipathways.org/instance/WP3303_r120561;http://www.wikipathways.org/instance/WP2203_r120724;http://www.wikipathways.org/instance/WP3945_r116679;http://www.wikipathways.org/instance/WP4149_r107159","Transcription factor","R-HSA-1170546 Prolactin receptor signaling;R-HSA-1226099 Signaling by FGFR in disease;R-HSA-1236394 Signaling by ERBB4;R-HSA-1251985 Nuclear signaling by ERBB4;R-HSA-1266695 Interleukin-7 signaling;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1433557 Signaling by SCF-KIT;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants;R-HSA-1839124 FGFR1 mutant receptor activation;R-HSA-186763 Downstream signal transduction;R-HSA-186797 Signaling by PDGF;R-HSA-2586552 Signaling by Leptin;R-HSA-449147 Signaling by Interleukins;R-HSA-451927 Interleukin-2 family signaling;R-HSA-512988 Interleukin-3"," Interleukin-5 and GM-CSF signaling;R-HSA-5655302 Signaling by FGFR1 in disease;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-8854691 Interleukin-20 family signaling;R-HSA-8983432 Interleukin-15 signaling;R-HSA-8985947 Interleukin-9 signaling;R-HSA-9006335 Signaling by Erythropoietin;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9020558 Interleukin-2 signaling;R-HSA-9020958 Interleukin-21 signaling;R-HSA-9027283 Erythropoietin activates STAT5;R-HSA-9607240 FLT3 Signaling;R-HSA-9645135 STAT5 Activation;R-HSA-9669938 Signaling by KIT in disease;R-HSA-9670439 Signaling by phosphorylated juxtamembrane"," extracellular and kinase domain KIT mutants;R-HSA-9674555 Signaling by CSF3 (G-CSF);R-HSA-9682385 FLT3 signaling in disease;R-HSA-9700206 Signaling by ALK in cancer;R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants;R-HSA-9703465 Signaling by FLT3 fusion proteins;R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants;R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling;R-HSA-9725370 Signaling by ALK fusions and activated point mutants;R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer;R-HSA-982772 Growth hormone receptor signaling",null,"ADIPOGENESIS;TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["P42677","40S ribosomal protein S27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3","RPS27",0.89567791,0.034096251,"nochange",170083,155546,172741,149787,151038,145554,1.080178968,0.987856034,1.097059642,0.95128124,0.959226207,0.924397909,"extracellular","K02978","RP-S27e; small subunit ribosomal protein S27e","hsa03010 Ribosome; hsa05171 Coronavirus disease - COVID-19","GO:0000028 ribosomal small subunit assembly; GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006412 translation; GO:0006413 translational initiation; GO:0006518 peptide metabolic process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006613 cotranslational protein targeting to membrane; GO:0006614 SRP-dependent cotranslational protein targeting to membrane; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016072 rRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034470 ncRNA processing; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042255 ribosome assembly; GO:0042274 ribosomal small subunit biogenesis; GO:0042886 amide transport; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045047 protein targeting to ER; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0070972 protein localization to endoplasmic reticulum; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072599 establishment of protein localization to endoplasmic reticulum; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005840 ribosome; GO:0015935 small ribosomal subunit; GO:0022626 cytosolic ribosome; GO:0022627 cytosolic small ribosomal subunit; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0008270 zinc ion binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG1779","40s ribosomal protein S27","WP477 CYTOPLASMIC RIBOSOMAL PROTEINS","http://www.wikipathways.org/instance/WP477_r117044",null,"R-HSA-1266738 Developmental Biology;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-1430728 Metabolism;R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-156842 Eukaryotic Translation Elongation;R-HSA-156902 Peptide chain elongation;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-192823 Viral mRNA Translation;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2262752 Cellular responses to stress;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-2408557 Selenocysteine synthesis;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-376176 Signaling by ROBO receptors;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-5663205 Infectious disease;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-72312 rRNA processing;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72649 Translation initiation complex formation;R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72695 Formation of the ternary complex"," and subsequently"," the 43S complex;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72764 Eukaryotic Translation Termination;R-HSA-72766 Translation;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-927802 Nonsense-Mediated Decay (NMD);R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9675108 Nervous system development;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-9711097 Cellular response to starvation;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-9754678 SARS-CoV-2 modulates host translation machinery;R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["P42785","Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1","PRCP",1.207325862,0.053099599,"nochange",16365.1,18303.7,19861.3,22866.5,20160,22809.1,0.815768944,0.912404447,0.990047829,1.139851303,1.004937453,1.136990023,"endoplasmic reticulum","K01285","PRCP; lysosomal Pro-X carboxypeptidase [EC:3.4.16.2]","hsa04974 Protein digestion and absorption; hsa04614 Renin-angiotensin system","GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001775 cell activation; GO:0001944 vasculature development; GO:0002155 regulation of thyroid hormone mediated signaling pathway; GO:0002252 immune effector process; GO:0002254 kinin cascade; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002353 plasma kallikrein-kinin cascade; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002526 acute inflammatory response; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003073 regulation of systemic arterial blood pressure; GO:0003085 negative regulation of systemic arterial blood pressure; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0007275 multicellular organism development; GO:0007596 blood coagulation; GO:0007597 blood coagulation"," intrinsic pathway; GO:0007599 hemostasis; GO:0008015 blood circulation; GO:0008152 metabolic process; GO:0008217 regulation of blood pressure; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010594 regulation of endothelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010646 regulation of cell communication; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0030334 regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033500 carbohydrate homeostasis; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036230 granulocyte activation; GO:0040012 regulation of locomotion; GO:0042060 wound healing; GO:0042119 neutrophil activation; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0044238 primary metabolic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045776 negative regulation of blood pressure; GO:0046903 secretion; GO:0048514 blood vessel morphogenesis; GO:0048583 regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048871 multicellular organismal homeostasis; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0060055 angiogenesis involved in wound healing; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0072359 circulatory system development; GO:0072376 protein activation cascade; GO:0072378 blood coagulation"," fibrin clot formation; GO:0097009 energy homeostasis; GO:1901564 organonitrogen compound metabolic process; GO:2000145 regulation of cell motility; GO:2000377 regulation of reactive oxygen species metabolic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0035577 azurophil granule membrane; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045178 basal part of cell; GO:0070820 tertiary granule; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:0101003 ficolin-1-rich granule membrane;","GO:0003824 catalytic activity; GO:0004177 aminopeptidase activity; GO:0004180 carboxypeptidase activity; GO:0004185 serine-type carboxypeptidase activity; GO:0008233 peptidase activity; GO:0008236 serine-type peptidase activity; GO:0008238 exopeptidase activity; GO:0008239 dipeptidyl-peptidase activity; GO:0016787 hydrolase activity; GO:0017171 serine hydrolase activity; GO:0070008 serine-type exopeptidase activity; GO:0140096 catalytic activity"," acting on a protein;","PF05577","PF05577 Serine carboxypeptidase S28","OR","KOG2183","Prolylcarboxypeptidase (angiotensinase C)",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation;R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade);R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-140837;https://reactome.org/PathwayBrowser/#/R-HSA-140877;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695","COMPLEMENT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT"]
["P43246","DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1","MSH2",1.258626978,0.000301815,"up",55639.8,54428,56905.5,68838.6,72130.5,69188,0.885207875,0.865928602,0.905344677,1.09519572,1.147568586,1.10075454,"nucleus","K08735","MSH2; DNA mismatch repair protein MSH2","hsa01524 Platinum drug resistance; hsa05210 Colorectal cancer; hsa05200 Pathways in cancer; hsa03430 Mismatch repair","GO:0000003 reproduction; GO:0000018 regulation of DNA recombination; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0001101 response to acid chemical; GO:0001701 in utero embryonic development; GO:0001775 cell activation; GO:0002200 somatic diversification of immune receptors; GO:0002204 somatic recombination of immunoglobulin genes involved in immune response; GO:0002208 somatic diversification of immunoglobulins involved in immune response; GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002285 lymphocyte activation involved in immune response; GO:0002312 B cell activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002377 immunoglobulin production; GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response; GO:0002440 production of molecular mediator of immune response; GO:0002443 leukocyte mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus; GO:0002566 somatic diversification of immune receptors via somatic mutation; GO:0002637 regulation of immunoglobulin production; GO:0002639 positive regulation of immunoglobulin production; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002702 positive regulation of production of molecular mediator of immune response; GO:0002703 regulation of leukocyte mediated immunity; GO:0002705 positive regulation of leukocyte mediated immunity; GO:0002706 regulation of lymphocyte mediated immunity; GO:0002708 positive regulation of lymphocyte mediated immunity; GO:0002712 regulation of B cell mediated immunity; GO:0002714 positive regulation of B cell mediated immunity; GO:0002819 regulation of adaptive immune response; GO:0002821 positive regulation of adaptive immune response; GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002889 regulation of immunoglobulin mediated immune response; GO:0002891 positive regulation of immunoglobulin mediated immune response; GO:0003006 developmental process involved in reproduction; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006298 mismatch repair; GO:0006301 postreplication repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006311 meiotic gene conversion; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006955 immune response; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007346 regulation of mitotic cell cycle; GO:0007548 sex differentiation; GO:0007568 aging; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008340 determination of adult lifespan; GO:0008406 gonad development; GO:0008584 male gonad development; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010165 response to X-ray; GO:0010212 response to ionizing radiation; GO:0010224 response to UV-B; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010520 regulation of reciprocal meiotic recombination; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016064 immunoglobulin mediated immune response; GO:0016310 phosphorylation; GO:0016444 somatic cell DNA recombination; GO:0016445 somatic diversification of immunoglobulins; GO:0016446 somatic hypermutation of immunoglobulin genes; GO:0016447 somatic recombination of immunoglobulin gene segments; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019724 B cell mediated immunity; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030183 B cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031570 DNA integrity checkpoint signaling; GO:0031573 mitotic intra-S DNA damage checkpoint signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0035556 intracellular signal transduction; GO:0035822 gene conversion; GO:0036297 interstrand cross-link repair; GO:0040020 regulation of meiotic nuclear division; GO:0042113 B cell activation; GO:0042221 response to chemical; GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043200 response to amino acid; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043570 maintenance of DNA repeat elements; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0045128 negative regulation of reciprocal meiotic recombination; GO:0045137 development of primary sexual characteristics; GO:0045190 isotype switching; GO:0045191 regulation of isotype switching; GO:0045321 leukocyte activation; GO:0045786 negative regulation of cell cycle; GO:0045830 positive regulation of isotype switching; GO:0045835 negative regulation of meiotic nuclear division; GO:0045910 negative regulation of DNA recombination; GO:0045911 positive regulation of DNA recombination; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0046546 development of primary male sexual characteristics; GO:0046649 lymphocyte activation; GO:0046661 male sex differentiation; GO:0048232 male gamete generation; GO:0048296 regulation of isotype switching to IgA isotypes; GO:0048298 positive regulation of isotype switching to IgA isotypes; GO:0048302 regulation of isotype switching to IgG isotypes; GO:0048304 positive regulation of isotype switching to IgG isotypes; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050864 regulation of B cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050871 positive regulation of B cell activation; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051094 positive regulation of developmental process; GO:0051095 regulation of helicase activity; GO:0051096 positive regulation of helicase activity; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051445 regulation of meiotic cell cycle; GO:0051447 negative regulation of meiotic cell cycle; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051784 negative regulation of nuclear division; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060631 regulation of meiosis I; GO:0061458 reproductive system development; GO:0061982 meiosis I cell cycle process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator; GO:0072521 purine-containing compound metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0110029 negative regulation of meiosis I; GO:1901135 carbohydrate derivative metabolic process; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:2000026 regulation of multicellular organismal development; GO:2000241 regulation of reproductive process; GO:2000242 negative regulation of reproductive process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032300 mismatch repair complex; GO:0032301 MutSalpha complex; GO:0032302 MutSbeta complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990391 DNA repair complex;","GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0000403 Y-form DNA binding; GO:0000404 heteroduplex DNA loop binding; GO:0000406 double-strand/single-strand DNA junction binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0003690 double-stranded DNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019237 centromeric DNA binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030983 mismatched DNA binding; GO:0032135 DNA insertion or deletion binding; GO:0032137 guanine/thymine mispair binding; GO:0032138 single base insertion or deletion binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043565 sequence-specific DNA binding; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF01624; PF05188; PF05192; PF05190; PF00488","PF01624 MutS domain I; PF05188 MutS domain II; PF05192 MutS domain III; PF05190 MutS family domain IV; PF00488 MutS domain V","L","KOG0219","Mismatch repair ATPase MSH2 (MutS family)","WP4216 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER;WP4352 CILIARY LANDSCAPE;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR;WP531 DNA MISMATCH REPAIR;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP1971 INTEGRATED CANCER PATHWAY;WP4963 P53 TRANSCRIPTIONAL GENE NETWORK;WP3303 RAC1PAK1P38MMP2 PATHWAY","http://www.wikipathways.org/instance/WP4216_r119088;http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP4016_r120667;http://www.wikipathways.org/instance/WP531_r117702;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP1971_r117762;http://www.wikipathways.org/instance/WP4963_r112233;http://www.wikipathways.org/instance/WP3303_r120561",null,"R-HSA-1643685 Disease;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5358508 Mismatch Repair;R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);R-HSA-5423599 Diseases of Mismatch Repair (MMR);R-HSA-5632927 Defective Mismatch Repair Associated With MSH3;R-HSA-5632928 Defective Mismatch Repair Associated With MSH2;R-HSA-5632968 Defective Mismatch Repair Associated With MSH6;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-9675135 Diseases of DNA repair","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5358508;https://reactome.org/PathwayBrowser/#/R-HSA-5358565;https://reactome.org/PathwayBrowser/#/R-HSA-5358606;https://reactome.org/PathwayBrowser/#/R-HSA-5423599;https://reactome.org/PathwayBrowser/#/R-HSA-5632927;https://reactome.org/PathwayBrowser/#/R-HSA-5632928;https://reactome.org/PathwayBrowser/#/R-HSA-5632968;https://reactome.org/PathwayBrowser/#/R-HSA-6796648;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-9675135","E2F TARGETS;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["P45973","Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1","CBX5",1.109649244,0.015742637,"nochange",32040.3,33551.1,32183.1,36220.6,34813.9,37460.9,0.931991531,0.975937837,0.936145313,1.053588526,1.012670293,1.0896665,"nucleus","K11587",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006950 response to stress; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0009611 response to wounding; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010948 negative regulation of cell cycle process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0042060 wound healing; GO:0045786 negative regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070316 regulation of G0 to G1 transition; GO:0070317 negative regulation of G0 to G1 transition; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000118 histone deacetylase complex; GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000781 chromosome"," telomeric region; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005721 pericentric heterochromatin; GO:0005730 nucleolus; GO:0010369 chromocenter; GO:0012505 endomembrane system; GO:0017053 transcription repressor complex; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1990234 transferase complex; GO:1990904 ribonucleoprotein complex;","GO:0003682 chromatin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0019899 enzyme binding; GO:0030674 protein-macromolecule adaptor activity; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0042826 histone deacetylase binding; GO:0043021 ribonucleoprotein complex binding; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0060090 molecular adaptor activity; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding;","PF00385; PF01393","PF00385 Chromo (CHRromatin Organisation MOdifier) domain; PF01393 Chromo shadow domain","B","KOG1911","Heterochromatin-associated protein HP1 and related CHROMO domain proteins","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME;WP4320 EFFECT OF PROGERIN ON GENES INVOLVED IN HUTCHINSONGILFORD PROGERIA SYNDROME","http://www.wikipathways.org/instance/WP4657_r120007;http://www.wikipathways.org/instance/WP4320_r116686","Transcription factor","R-HSA-109582 Hemostasis;R-HSA-212436 Generic Transcription Pathway;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-392499 Metabolism of proteins;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-597592 Post-translational protein modification;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953750 Transcriptional Regulation by E2F6;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4551638;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953750;https://reactome.org/PathwayBrowser/#/R-HSA-983231","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["P46776","60S ribosomal protein L27a OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2","RPL27A",0.546240051,{"v":1.42401e-05,"d":"1.42E-05"},"down",412743,399519,393446,213177,217887,227542,1.328348122,1.285788767,1.266243777,0.686076487,0.701234878,0.73230797,"cytoplasm","K02900","RP-L27Ae; large subunit ribosomal protein L27Ae","hsa03010 Ribosome; hsa05171 Coronavirus disease - COVID-19","GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0002181 cytoplasmic translation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006412 translation; GO:0006413 translational initiation; GO:0006518 peptide metabolic process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006613 cotranslational protein targeting to membrane; GO:0006614 SRP-dependent cotranslational protein targeting to membrane; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019538 protein metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042886 amide transport; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045047 protein targeting to ER; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070972 protein localization to endoplasmic reticulum; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0072599 establishment of protein localization to endoplasmic reticulum; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0005840 ribosome; GO:0012505 endomembrane system; GO:0015934 large ribosomal subunit; GO:0022625 cytosolic large ribosomal subunit; GO:0022626 cytosolic ribosome; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044391 ribosomal subunit; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG1742","60s ribosomal protein L15/L27","WP477 CYTOPLASMIC RIBOSOMAL PROTEINS","http://www.wikipathways.org/instance/WP477_r117044",null,"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-156842 Eukaryotic Translation Elongation;R-HSA-156902 Peptide chain elongation;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-192823 Viral mRNA Translation;R-HSA-2262752 Cellular responses to stress;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-2408557 Selenocysteine synthesis;R-HSA-376176 Signaling by ROBO receptors;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-5663205 Infectious disease;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-72312 rRNA processing;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72764 Eukaryotic Translation Termination;R-HSA-72766 Translation;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-927802 Nonsense-Mediated Decay (NMD);R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency;R-HSA-9675108 Nervous system development;R-HSA-9711097 Cellular response to starvation;R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156827;https://reactome.org/PathwayBrowser/#/R-HSA-156842;https://reactome.org/PathwayBrowser/#/R-HSA-156902;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168273;https://reactome.org/PathwayBrowser/#/R-HSA-1799339;https://reactome.org/PathwayBrowser/#/R-HSA-192823;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2408522;https://reactome.org/PathwayBrowser/#/R-HSA-2408557;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72689;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72764;https://reactome.org/PathwayBrowser/#/R-HSA-72766;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9010553;https://reactome.org/PathwayBrowser/#/R-HSA-927802;https://reactome.org/PathwayBrowser/#/R-HSA-9633012;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9711097;https://reactome.org/PathwayBrowser/#/R-HSA-975956;https://reactome.org/PathwayBrowser/#/R-HSA-975957"]
["P46779","60S ribosomal protein L28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3","RPL28",0.438336465,1.80156E-4,"down",138380,138092,148755,57028.2,60314.8,69049.5,1.3575106749999999,1.354685389,1.45928964,0.559447827,0.591689441,0.677377029,"mitochondria","K02903","RP-L28e; large subunit ribosomal protein L28e","hsa03010 Ribosome; hsa05171 Coronavirus disease - COVID-19","GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0002181 cytoplasmic translation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006412 translation; GO:0006413 translational initiation; GO:0006518 peptide metabolic process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006613 cotranslational protein targeting to membrane; GO:0006614 SRP-dependent cotranslational protein targeting to membrane; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019538 protein metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042886 amide transport; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045047 protein targeting to ER; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070972 protein localization to endoplasmic reticulum; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0072599 establishment of protein localization to endoplasmic reticulum; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0022625 cytosolic large ribosomal subunit; GO:0022626 cytosolic ribosome; GO:0030425 dendrite; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0044391 ribosomal subunit; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;",null,null,"J","KOG3412","60S ribosomal protein L28","WP477 CYTOPLASMIC RIBOSOMAL PROTEINS","http://www.wikipathways.org/instance/WP477_r117044",null,"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-156842 Eukaryotic Translation Elongation;R-HSA-156902 Peptide chain elongation;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-192823 Viral mRNA Translation;R-HSA-2262752 Cellular responses to stress;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-2408557 Selenocysteine synthesis;R-HSA-376176 Signaling by ROBO receptors;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-5663205 Infectious disease;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-72312 rRNA processing;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72764 Eukaryotic Translation Termination;R-HSA-72766 Translation;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-927802 Nonsense-Mediated Decay (NMD);R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency;R-HSA-9675108 Nervous system development;R-HSA-9711097 Cellular response to starvation;R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156827;https://reactome.org/PathwayBrowser/#/R-HSA-156842;https://reactome.org/PathwayBrowser/#/R-HSA-156902;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168273;https://reactome.org/PathwayBrowser/#/R-HSA-1799339;https://reactome.org/PathwayBrowser/#/R-HSA-192823;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2408522;https://reactome.org/PathwayBrowser/#/R-HSA-2408557;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72689;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72764;https://reactome.org/PathwayBrowser/#/R-HSA-72766;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9010553;https://reactome.org/PathwayBrowser/#/R-HSA-927802;https://reactome.org/PathwayBrowser/#/R-HSA-9633012;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9711097;https://reactome.org/PathwayBrowser/#/R-HSA-975956;https://reactome.org/PathwayBrowser/#/R-HSA-975957"]
["P47985","Cytochrome b-c1 complex subunit Rieske"," mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2","UQCRFS1",1.121553959,0.016460008,"nochange",103457,96888.3,93742.2,110318,109482,110035,0.994902412,0.931733989,0.90147927,1.06088176,1.0528423,1.058160268,"mitochondria","K00411","UQCRFS1; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]","hsa04932 Non-alcoholic fatty liver disease; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa05016 Huntington disease; hsa00190 Oxidative phosphorylation; hsa05415 Diabetic cardiomyopathy; hsa05012 Parkinson disease; hsa05010 Alzheimer disease; hsa04260 Cardiac muscle contraction; hsa04714 Thermogenesis; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis; hsa05020 Prion disease; hsa01100 Metabolic pathways","GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006122 mitochondrial electron transport"," ubiquinol to cytochrome c; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016310 phosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046034 ATP metabolic process; GO:0046483 heterocycle metabolic process; GO:0046677 response to antibiotic; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048580 regulation of post-embryonic development; GO:0048582 positive regulation of post-embryonic development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061062 regulation of nematode larval development; GO:0061063 positive regulation of nematode larval development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005746 mitochondrial respirasome; GO:0005750 mitochondrial respiratory chain complex III; GO:0005751 mitochondrial respiratory chain complex IV; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045275 respiratory chain complex III; GO:0045277 respiratory chain complex IV; GO:0070069 cytochrome complex; GO:0070469 respirasome; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:0098803 respiratory chain complex; GO:1902494 catalytic complex; GO:1990204 oxidoreductase complex;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0008121 ubiquinol-cytochrome-c reductase activity; GO:0009055 electron transfer activity; GO:0016491 oxidoreductase activity; GO:0016679 oxidoreductase activity"," acting on diphenols and related substances as donors; GO:0044877 protein-containing complex binding;","PF09165; PF00355","PF09165 Ubiquinol-cytochrome c reductase 8 kDa"," N-terminal; PF00355 Rieske [2Fe-2S] domain","C","KOG1671","Ubiquinol cytochrome c reductase"," subunit RIP1","WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA;WP4921 MITOCHONDRIAL COMPLEX III ASSEMBLY;WP4396 NONALCOHOLIC FATTY LIVER DISEASE","http://www.wikipathways.org/instance/WP111_r117097;http://www.wikipathways.org/instance/WP4921_r116643;http://www.wikipathways.org/instance/WP4396_r98945",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-163200 Respiratory electron transport"," ATP synthesis by chemiosmotic coupling"," and heat production by uncoupling proteins.;R-HSA-611105 Respiratory electron transport","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-163200;https://reactome.org/PathwayBrowser/#/R-HSA-611105","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["P48506","Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2","GCLC",1.318200112,0.000252632,"up",48314.6,45919.5,47888.1,63574.2,63316,60455.3,0.879866524,0.836248895,0.87209945,1.157762051,1.153059921,1.10096316,"cytoplasm","K11204","GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]","hsa04216 Ferroptosis; hsa00270 Cysteine and methionine metabolism; hsa00480 Glutathione metabolism; hsa01240 Biosynthesis of cofactors; hsa01100 Metabolic pathways","GO:0000096 sulfur amino acid metabolic process; GO:0000302 response to reactive oxygen species; GO:0000303 response to superoxide; GO:0000305 response to oxygen radical; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001101 response to acid chemical; GO:0001678 cellular glucose homeostasis; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0003254 regulation of membrane depolarization; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006082 organic acid metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006534 cysteine metabolic process; GO:0006536 glutamate metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006749 glutathione metabolic process; GO:0006750 glutathione biosynthetic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007568 aging; GO:0007584 response to nutrient; GO:0008015 blood circulation; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008637 apoptotic mitochondrial changes; GO:0009058 biosynthetic process; GO:0009064 glutamine family amino acid metabolic process; GO:0009069 serine family amino acid metabolic process; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009410 response to xenobiotic stimulus; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0014823 response to activity; GO:0016043 cellular component organization; GO:0019184 nonribosomal peptide biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0019752 carboxylic acid metabolic process; GO:0019852 L-ascorbic acid metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032354 response to follicle-stimulating hormone; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033500 carbohydrate homeostasis; GO:0034097 response to cytokine; GO:0034284 response to monosaccharide; GO:0034641 cellular nitrogen compound metabolic process; GO:0034698 response to gonadotropin; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035150 regulation of tube size; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035728 response to hepatocyte growth factor; GO:0035729 cellular response to hepatocyte growth factor stimulus; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042391 regulation of membrane potential; GO:0042398 cellular modified amino acid biosynthetic process; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042981 regulation of apoptotic process; GO:0043043 peptide biosynthetic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043200 response to amino acid; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043648 dicarboxylic acid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0044752 response to human chorionic gonadotropin; GO:0045454 cell redox homeostasis; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046685 response to arsenic-containing substance; GO:0046686 response to cadmium ion; GO:0046688 response to copper ion; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051409 response to nitrosative stress; GO:0051716 cellular response to stimulus; GO:0051881 regulation of mitochondrial membrane potential; GO:0051900 regulation of mitochondrial depolarization; GO:0055082 cellular chemical homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070555 response to interleukin-1; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071229 cellular response to acid chemical; GO:0071230 cellular response to amino acid stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071322 cellular response to carbohydrate stimulus; GO:0071326 cellular response to monosaccharide stimulus; GO:0071331 cellular response to hexose stimulus; GO:0071333 cellular response to glucose stimulus; GO:0071363 cellular response to growth factor stimulus; GO:0071371 cellular response to gonadotropin stimulus; GO:0071372 cellular response to follicle-stimulating hormone stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071774 response to fibroblast growth factor; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0097066 response to thyroid hormone; GO:0097067 cellular response to thyroid hormone stimulus; GO:0097068 response to thyroxine; GO:0097069 cellular response to thyroxine stimulus; GO:0104004 cellular response to environmental stimulus; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1904386 response to L-phenylalanine derivative; GO:1904387 cellular response to L-phenylalanine derivative; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000489 regulation of hepatic stellate cell activation; GO:2000490 negative regulation of hepatic stellate cell activation; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001237 negative regulation of extrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0017109 glutamate-cysteine ligase complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:1902494 catalytic complex;","GO:0000166 nucleotide binding; GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004357 glutamate-cysteine ligase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016595 glutamate binding; GO:0016597 amino acid binding; GO:0016874 ligase activity; GO:0016879 ligase activity"," forming carbon-nitrogen bonds; GO:0016881 acid-amino acid ligase activity; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0031406 carboxylic acid binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043177 organic acid binding; GO:0043531 ADP binding; GO:0046872 metal ion binding; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"H","KOG3754","Gamma-glutamylcysteine synthetase","WP5113 ANTIVIRAL AND ANTIINFLAMMATORY EFFECTS OF NRF2 ON SARSCOV2 PATHWAY;WP2864 APOPTOSISRELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER;WP2586 ARYL HYDROCARBON RECEPTOR PATHWAY WP2586;WP4504 CYSTEINE AND METHIONINE CATABOLISM;WP4313 FERROPTOSIS;WP4518 GAMMAGLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE INCLUDING DISEASES;WP100 GLUTATHIONE METABOLISM;WP2884 NRF2 PATHWAY;WP4357 NRF2ARE REGULATION;WP2882 NUCLEAR RECEPTORS METAPATHWAY;WP3940 ONECARBON METABOLISM AND RELATED PATHWAYS;WP408 OXIDATIVE STRESS RESPONSE;WP3612 PHOTODYNAMIC THERAPYINDUCED NFE2L2 NRF2 SURVIVAL SIGNALING;WP3 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS;WP2525 TRANSSULFURATION AND ONECARBON METABOLISM;WP4698 VITAMIN DSENSITIVE CALCIUM SIGNALING IN DEPRESSION","http://www.wikipathways.org/instance/WP5113_r119486;http://www.wikipathways.org/instance/WP2864_r108133;http://www.wikipathways.org/instance/WP2586_r120796;http://www.wikipathways.org/instance/WP4504_r119316;http://www.wikipathways.org/instance/WP4313_r120500;http://www.wikipathways.org/instance/WP4518_r119313;http://www.wikipathways.org/instance/WP100_r107114;http://www.wikipathways.org/instance/WP2884_r106658;http://www.wikipathways.org/instance/WP4357_r98705;http://www.wikipathways.org/instance/WP2882_r117808;http://www.wikipathways.org/instance/WP3940_r119248;http://www.wikipathways.org/instance/WP408_r116900;http://www.wikipathways.org/instance/WP3612_r106540;http://www.wikipathways.org/instance/WP3_r120028;http://www.wikipathways.org/instance/WP2525_r116582;http://www.wikipathways.org/instance/WP4698_r119119",null,"R-HSA-1430728 Metabolism;R-HSA-156580 Phase II - Conjugation of compounds;R-HSA-156590 Glutathione conjugation;R-HSA-1643685 Disease;R-HSA-174403 Glutathione synthesis and recycling;R-HSA-211859 Biological oxidations;R-HSA-2262752 Cellular responses to stress;R-HSA-5578999 Defective GCLC causes HAGGSD;R-HSA-5579029 Metabolic disorders of biological oxidation enzymes;R-HSA-5668914 Diseases of metabolism;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156580;https://reactome.org/PathwayBrowser/#/R-HSA-156590;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-174403;https://reactome.org/PathwayBrowser/#/R-HSA-211859;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-5578999;https://reactome.org/PathwayBrowser/#/R-HSA-5579029;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9711123;https://reactome.org/PathwayBrowser/#/R-HSA-9755511;https://reactome.org/PathwayBrowser/#/R-HSA-9759194","GLYCOLYSIS;HEME METABOLISM;MTORC1 SIGNALING;REACTIVE OXYGEN SPECIES PATHWAY;XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["P48681","Nestin OS=Homo sapiens OX=9606 GN=NES PE=1 SV=2","NES",1.297262989,0.186106239,"nochange",2786.62,2619.74,1849,3761.25,3041.26,2609.6,1.003134849,0.943060944,0.665607918,1.353984738,1.094800831,0.93941072,"nucleus","K07609",null,null,"GO:0000086 G2/M transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000902 cell morphogenesis; GO:0001654 eye development; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0009314 response to radiation; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010212 response to ionizing radiation; GO:0010638 positive regulation of organelle organization; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0021545 cranial nerve development; GO:0021675 nerve development; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030842 regulation of intermediate filament depolymerization; GO:0030844 positive regulation of intermediate filament depolymerization; GO:0031076 embryonic camera-type eye development; GO:0031667 response to nutrient levels; GO:0032091 negative regulation of protein binding; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043010 camera-type eye development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043243 positive regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043393 regulation of protein binding; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0044092 negative regulation of molecular function; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044839 cell cycle G2/M phase transition; GO:0045108 regulation of intermediate filament polymerization or depolymerization; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048568 embryonic organ development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0060322 head development; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0072089 stem cell proliferation; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901879 regulation of protein depolymerization; GO:1901881 positive regulation of protein depolymerization; GO:1903047 mitotic cell cycle process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000179 positive regulation of neural precursor cell proliferation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005882 intermediate filament; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045111 intermediate filament cytoskeleton; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0001664 G protein-coupled receptor binding; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019215 intermediate filament binding; GO:0031730 CCR5 chemokine receptor binding; GO:0042379 chemokine receptor binding; GO:0044877 protein-containing complex binding; GO:0048020 CCR chemokine receptor binding;"]
["P49005","DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1","POLD2",0.833156548,0.051737638,"nochange",15414.3,14249.6,16531.5,14174.1,12095.2,12218.7,1.092136121,1.009614635,1.17129213,1.004265299,0.856970788,0.865721027,"mitochondria","K02328","POLD2; DNA polymerase delta subunit 2","hsa03030 DNA replication; hsa03440 Homologous recombination; hsa03410 Base excision repair; hsa03420 Nucleotide excision repair; hsa03430 Mismatch repair","GO:0000723 telomere maintenance; GO:0000731 DNA synthesis involved in DNA repair; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006271 DNA strand elongation involved in DNA replication; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006296 nucleotide-excision repair"," DNA incision"," 5'-to lesion; GO:0006297 nucleotide-excision repair"," DNA gap filling; GO:0006301 postreplication repair; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019725 cellular homeostasis; GO:0019985 translesion synthesis; GO:0022402 cell cycle process; GO:0022616 DNA strand elongation; GO:0032200 telomere organization; GO:0032201 telomere maintenance via semi-conservative replication; GO:0033260 nuclear DNA replication; GO:0033554 cellular response to stress; GO:0033683 nucleotide-excision repair"," DNA incision; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044786 cell cycle DNA replication; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0051276 chromosome organization; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0060249 anatomical structure homeostasis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000228 nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0030894 replisome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0042575 DNA polymerase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043596 nuclear replication fork; GO:0043601 nuclear replisome; GO:0043625 delta DNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0003887 DNA-directed DNA polymerase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0034061 DNA polymerase activity; GO:0140097 catalytic activity"," acting on DNA;","PF18018","PF18018 DNA polymerase delta subunit OB-fold domain","L","KOG2732","DNA polymerase delta"," regulatory subunit 55","WP4752 BASE EXCISION REPAIR;WP531 DNA MISMATCH REPAIR;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP466 DNA REPLICATION;WP186 HOMOLOGOUS RECOMBINATION;WP4753 NUCLEOTIDE EXCISION REPAIR;WP5114 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM;WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP4752_r119239;http://www.wikipathways.org/instance/WP531_r117702;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP466_r117096;http://www.wikipathways.org/instance/WP186_r118416;http://www.wikipathways.org/instance/WP4753_r119238;http://www.wikipathways.org/instance/WP5114_r119169;http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template;R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex;R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway;R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-174411 Polymerase switching on the C-strand of the telomere;R-HSA-174414 Processive synthesis on the C-strand of the telomere;R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis;R-HSA-174437 Removal of the Flap Intermediate from the C-strand;R-HSA-180786 Extension of Telomeres;R-HSA-5358508 Mismatch Repair;R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha);R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta);R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair;R-HSA-5656169 Termination of translesion DNA synthesis;R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-5696400 Dual Incision in GG-NER;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-69091 Polymerase switching;R-HSA-69109 Leading Strand Synthesis;R-HSA-69166 Removal of the Flap Intermediate;R-HSA-69183 Processive synthesis on the lagging strand;R-HSA-69186 Lagging Strand Synthesis;R-HSA-69190 DNA strand elongation;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-73884 Base Excision Repair;R-HSA-73886 Chromosome Maintenance;R-HSA-73893 DNA Damage Bypass;R-HSA-73894 DNA Repair;R-HSA-73933 Resolution of Abasic Sites (AP sites)","https://reactome.org/PathwayBrowser/#/R-HSA-110313;https://reactome.org/PathwayBrowser/#/R-HSA-110314;https://reactome.org/PathwayBrowser/#/R-HSA-110373;https://reactome.org/PathwayBrowser/#/R-HSA-157579;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-174411;https://reactome.org/PathwayBrowser/#/R-HSA-174414;https://reactome.org/PathwayBrowser/#/R-HSA-174417;https://reactome.org/PathwayBrowser/#/R-HSA-174437;https://reactome.org/PathwayBrowser/#/R-HSA-180786;https://reactome.org/PathwayBrowser/#/R-HSA-5358508;https://reactome.org/PathwayBrowser/#/R-HSA-5358565;https://reactome.org/PathwayBrowser/#/R-HSA-5358606;https://reactome.org/PathwayBrowser/#/R-HSA-5651801;https://reactome.org/PathwayBrowser/#/R-HSA-5656169;https://reactome.org/PathwayBrowser/#/R-HSA-5685942;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693538;https://reactome.org/PathwayBrowser/#/R-HSA-5693567;https://reactome.org/PathwayBrowser/#/R-HSA-5696397;https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-5696399;https://reactome.org/PathwayBrowser/#/R-HSA-5696400;https://reactome.org/PathwayBrowser/#/R-HSA-6781827;https://reactome.org/PathwayBrowser/#/R-HSA-6782135;https://reactome.org/PathwayBrowser/#/R-HSA-6782210;https://reactome.org/PathwayBrowser/#/R-HSA-69091;https://reactome.org/PathwayBrowser/#/R-HSA-69109;https://reactome.org/PathwayBrowser/#/R-HSA-69166;https://reactome.org/PathwayBrowser/#/R-HSA-69183;https://reactome.org/PathwayBrowser/#/R-HSA-69186;https://reactome.org/PathwayBrowser/#/R-HSA-69190;https://reactome.org/PathwayBrowser/#/R-HSA-69239;https://reactome.org/PathwayBrowser/#/R-HSA-69242;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69306;https://reactome.org/PathwayBrowser/#/R-HSA-73884;https://reactome.org/PathwayBrowser/#/R-HSA-73886;https://reactome.org/PathwayBrowser/#/R-HSA-73893;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-73933","E2F TARGETS;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["P49368","T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4","CCT3",0.821391758,0.000109704,"down",485834,504809,498510,411645,402823,408710,1.074722812,1.116697778,1.102763638,0.910607887,0.891092569,0.904115316,"mitochondria","K09495",null,null,"GO:0000003 reproduction; GO:0006457 protein folding; GO:0006458 'de novo' protein folding; GO:0006810 transport; GO:0007338 single fertilization; GO:0007339 binding of sperm to zona pellucida; GO:0008037 cell recognition; GO:0009566 fertilization; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0009988 cell-cell recognition; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031647 regulation of protein stability; GO:0032204 regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032212 positive regulation of telomere maintenance via telomerase; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0035036 sperm-egg recognition; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046931 pore complex assembly; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061077 chaperone-mediated protein folding; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070202 regulation of establishment of protein localization to chromosome; GO:0070203 regulation of establishment of protein localization to telomere; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901998 toxin transport; GO:1903829 positive regulation of protein localization; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904358 positive regulation of telomere maintenance via telomere lengthening; GO:1904814 regulation of protein localization to chromosome"," telomeric region; GO:1904816 positive regulation of protein localization to chromosome"," telomeric region; GO:1904851 positive regulation of establishment of protein localization to telomere; GO:1904951 positive regulation of establishment of protein localization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000573 positive regulation of DNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0002199 zona pellucida receptor complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005832 chaperonin-containing T-complex; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005886 plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0032991 protein-containing complex; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0101031 chaperone complex;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0044183 protein folding chaperone; GO:0051082 unfolded protein binding;",null,null,"O","KOG0364","Chaperonin complex component"," TCP-1 gamma subunit (CCT3)","WP4949 16P112 PROXIMAL DELETION SYNDROME","http://www.wikipathways.org/instance/WP4949_r115778",null,"R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-389957 Prefoldin mediated transfer of substrate  to CCT/TriC;R-HSA-389958 Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding;R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC;R-HSA-390450 Folding of actin by CCT/TriC;R-HSA-390466 Chaperonin-mediated protein folding;R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins;R-HSA-5617833 Cilium Assembly;R-HSA-5620920 Cargo trafficking to the periciliary membrane;R-HSA-5620922 BBSome-mediated cargo-targeting to cilium;R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding","https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-389957;https://reactome.org/PathwayBrowser/#/R-HSA-389958;https://reactome.org/PathwayBrowser/#/R-HSA-389960;https://reactome.org/PathwayBrowser/#/R-HSA-390450;https://reactome.org/PathwayBrowser/#/R-HSA-390466;https://reactome.org/PathwayBrowser/#/R-HSA-390471;https://reactome.org/PathwayBrowser/#/R-HSA-391251;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620920;https://reactome.org/PathwayBrowser/#/R-HSA-5620922;https://reactome.org/PathwayBrowser/#/R-HSA-6814122","MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["P49662","Caspase-4 OS=Homo sapiens OX=9606 GN=CASP4 PE=1 SV=1","CASP4",0.430760312,0.000139668,"down",10371.6,10715.7,11427,4202.95,4966.88,4836.04,1.337690726,1.382071476,1.473812327,0.542080994,0.640609869,0.623734608,"cytoplasm","K04394","CASP4; caspase 4 [EC:3.4.22.57 3.4.22.64]","hsa05132 Salmonella infection; hsa04621 NOD-like receptor signaling pathway; hsa04613 Neutrophil extracellular trap formation; hsa05130 Pathogenic Escherichia coli infection; hsa05131 Shigellosis","GO:0000003 reproduction; GO:0001666 response to hypoxia; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001960 negative regulation of cytokine-mediated signaling pathway; GO:0001961 positive regulation of cytokine-mediated signaling pathway; GO:0002237 response to molecule of bacterial origin; GO:0002376 immune system process; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009612 response to mechanical stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010225 response to UV-C; GO:0010243 response to organonitrogen compound; GO:0010466 negative regulation of peptidase activity; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010623 programmed cell death involved in cell development; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010951 negative regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0010955 negative regulation of protein processing; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016485 protein processing; GO:0016540 protein autoprocessing; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway; GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway; GO:0032091 negative regulation of protein binding; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032496 response to lipopolysaccharide; GO:0032502 developmental process; GO:0032651 regulation of interleukin-1 beta production; GO:0032652 regulation of interleukin-1 production; GO:0032691 negative regulation of interleukin-1 beta production; GO:0032692 negative regulation of interleukin-1 production; GO:0032731 positive regulation of interleukin-1 beta production; GO:0032732 positive regulation of interleukin-1 production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034341 response to interferon-gamma; GO:0034644 cellular response to UV; GO:0034976 response to endoplasmic reticulum stress; GO:0035234 ectopic germ cell programmed cell death; GO:0035556 intracellular signal transduction; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043393 regulation of protein binding; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044238 primary metabolic process; GO:0045087 innate immune response; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050727 regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051604 protein maturation; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060759 regulation of response to cytokine stimulus; GO:0060760 positive regulation of response to cytokine stimulus; GO:0060761 negative regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; GO:0070201 regulation of establishment of protein localization; GO:0070269 pyroptosis; GO:0070482 response to oxygen levels; GO:0070613 regulation of protein processing; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071346 cellular response to interferon-gamma; GO:0071396 cellular response to lipid; GO:0071417 cellular response to organonitrogen compound; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071494 cellular response to UV-C; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097340 inhibition of cysteine-type endopeptidase activity; GO:0097341 zymogen inhibition; GO:0097435 supramolecular fiber organization; GO:0104004 cellular response to environmental stimulus; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway; GO:1903317 regulation of protein maturation; GO:1903318 negative regulation of protein maturation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904645 response to amyloid-beta; GO:1904646 cellular response to amyloid-beta; GO:1904950 negative regulation of establishment of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body; GO:0061702 inflammasome complex; GO:0071944 cell periphery; GO:0072557 IPAF inflammasome complex; GO:0072558 NLRP1 inflammasome complex; GO:0072559 NLRP3 inflammasome complex; GO:0097169 AIM2 inflammasome complex; GO:0097179 protease inhibitor complex; GO:0120025 plasma membrane bounded cell projection; GO:1904090 peptidase inhibitor complex;","GO:0002020 protease binding; GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004197 cysteine-type endopeptidase activity; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0004869 cysteine-type endopeptidase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process; GO:0016504 peptidase activator activity; GO:0016505 peptidase activator activity involved in apoptotic process; GO:0016787 hydrolase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0042802 identical protein binding; GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process; GO:0050700 CARD domain binding; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0089720 caspase binding; GO:0097110 scaffold protein binding; GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF00619; PF00656","PF00619 Caspase recruitment domain; PF00656 Caspase domain","D","KOG3573","Caspase"," apoptotic cysteine protease","WP254 APOPTOSIS;WP1772 APOPTOSIS MODULATION AND SIGNALING","http://www.wikipathways.org/instance/WP254_r118382;http://www.wikipathways.org/instance/WP1772_r120736",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168638 NOD1/2 Signaling Pathway;R-HSA-168643 Nucleotide-binding domain"," leucine rich repeat containing receptor (NLR) signaling pathways;R-HSA-5218859 Regulated Necrosis;R-HSA-5357801 Programmed Cell Death;R-HSA-5620971 Pyroptosis","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168638;https://reactome.org/PathwayBrowser/#/R-HSA-168643;https://reactome.org/PathwayBrowser/#/R-HSA-5218859;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-5620971","APOPTOSIS;COMPLEMENT;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APOPTOSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["P49750","YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4","YLPM1",1.020721177,0.432380489,"nochange",17875.7,18285.1,18339,19120.9,18727,17781.2,0.973896952,0.996201724,0.999138283,1.041737455,1.020277148,0.968748439,"nucleus","K17602",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032204 regulation of telomere maintenance; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008157 protein phosphatase 1 binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0140110 transcription regulator activity;","PF13671","PF13671 AAA domain","V","KOG2400","Nuclear protein ZAP"]
["P49815","Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2","TSC2",0.703831023,0.019934251,"nochange",3801.81,3388.65,4349.54,3033.99,2518.55,2569.67,1.160137136,1.034059752,1.32727908,0.925833871,0.768545347,0.784144814,"plasma membrane","K07207","TSC2; tuberous sclerosis 2","hsa04072 Phospholipase D signaling pathway; hsa04150 mTOR signaling pathway; hsa04115 p53 signaling pathway; hsa04140 Autophagy - animal; hsa04919 Thyroid hormone signaling pathway; hsa05163 Human cytomegalovirus infection; hsa05231 Choline metabolism in cancer; hsa05168 Herpes simplex virus 1 infection; hsa05165 Human papillomavirus infection; hsa04211 Longevity regulating pathway; hsa04714 Thermogenesis; hsa04218 Cellular senescence; hsa04151 PI3K-Akt signaling pathway; hsa04910 Insulin signaling pathway; hsa04152 AMPK signaling pathway","GO:0000003 reproduction; GO:0001558 regulation of cell growth; GO:0001666 response to hypoxia; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001936 regulation of endothelial cell proliferation; GO:0001937 negative regulation of endothelial cell proliferation; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006469 negative regulation of protein kinase activity; GO:0006606 protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006913 nucleocytoplasmic transport; GO:0006915 apoptotic process; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007399 nervous system development; GO:0007507 heart development; GO:0007552 metamorphosis; GO:0007568 aging; GO:0007584 response to nutrient; GO:0007610 behavior; GO:0008104 protein localization; GO:0008219 cell death; GO:0008285 negative regulation of cell population proliferation; GO:0008340 determination of adult lifespan; GO:0008361 regulation of cell size; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0008643 carbohydrate transport; GO:0008645 hexose transmembrane transport; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010717 regulation of epithelial to mesenchymal transition; GO:0010719 negative regulation of epithelial to mesenchymal transition; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010762 regulation of fibroblast migration; GO:0010763 positive regulation of fibroblast migration; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010821 regulation of mitochondrion organization; GO:0010823 negative regulation of mitochondrion organization; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0012501 programmed cell death; GO:0014020 primary neural tube formation; GO:0014065 phosphatidylinositol 3-kinase signaling; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling; GO:0014070 response to organic cyclic compound; GO:0015031 protein transport; GO:0015749 monosaccharide transmembrane transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016239 positive regulation of macroautophagy; GO:0016241 regulation of macroautophagy; GO:0016242 negative regulation of macroautophagy; GO:0016331 morphogenesis of embryonic epithelium; GO:0017038 protein import; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021915 neural tube development; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030010 establishment of cell polarity; GO:0030030 cell projection organization; GO:0030100 regulation of endocytosis; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030308 negative regulation of cell growth; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0031929 TOR signaling; GO:0032006 regulation of TOR signaling; GO:0032007 negative regulation of TOR signaling; GO:0032008 positive regulation of TOR signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032594 protein transport within lipid bilayer; GO:0032596 protein transport into membrane raft; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033673 negative regulation of kinase activity; GO:0034219 carbohydrate transmembrane transport; GO:0034394 protein localization to cell surface; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035069 larval midgut histolysis; GO:0035148 tube formation; GO:0035176 social behavior; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0038202 TORC1 signaling; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042592 homeostatic process; GO:0042632 cholesterol homeostasis; GO:0042886 amide transport; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043276 anoikis; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043434 response to peptide hormone; GO:0043491 protein kinase B signaling; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044703 multi-organism reproductive process; GO:0044860 protein localization to plasma membrane raft; GO:0044861 protein transport into plasma membrane raft; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045785 positive regulation of cell adhesion; GO:0045792 negative regulation of cell size; GO:0045806 negative regulation of endocytosis; GO:0045859 regulation of protein kinase activity; GO:0045886 negative regulation of synaptic assembly at neuromuscular junction; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046323 glucose import; GO:0046620 regulation of organ growth; GO:0046621 negative regulation of organ growth; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0046677 response to antibiotic; GO:0046907 intracellular transport; GO:0048009 insulin-like growth factor receptor signaling pathway; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048145 regulation of fibroblast proliferation; GO:0048147 negative regulation of fibroblast proliferation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048548 regulation of pinocytosis; GO:0048550 negative regulation of pinocytosis; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050678 regulation of epithelial cell proliferation; GO:0050680 negative regulation of epithelial cell proliferation; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050771 negative regulation of axonogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0050918 positive chemotaxis; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051291 protein heterooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051348 negative regulation of transferase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051668 localization within membrane; GO:0051703 biological process involved in intraspecies interaction between organisms; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051896 regulation of protein kinase B signaling; GO:0051898 negative regulation of protein kinase B signaling; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051964 negative regulation of synapse assembly; GO:0055085 transmembrane transport; GO:0055088 lipid homeostasis; GO:0055092 sterol homeostasis; GO:0060033 anatomical structure regression; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0060627 regulation of vesicle-mediated transport; GO:0060998 regulation of dendritic spine development; GO:0060999 positive regulation of dendritic spine development; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070482 response to oxygen levels; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071236 cellular response to antibiotic; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0072594 establishment of protein localization to organelle; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090150 establishment of protein localization to membrane; GO:0098657 import into cell; GO:0099174 regulation of presynapse organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1901524 regulation of mitophagy; GO:1901525 negative regulation of mitophagy; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902349 response to chloroquine; GO:1902350 cellular response to chloroquine; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903044 protein localization to membrane raft; GO:1903146 regulation of autophagy of mitochondrion; GO:1903147 negative regulation of autophagy of mitochondrion; GO:1903432 regulation of TORC1 signaling; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903939 regulation of TORC2 signaling; GO:1904262 negative regulation of TORC1 signaling; GO:1904396 regulation of neuromuscular junction development; GO:1904397 negative regulation of neuromuscular junction development; GO:1904515 positive regulation of TORC2 signaling; GO:1904659 glucose transmembrane transport; GO:1905562 regulation of vascular endothelial cell proliferation; GO:1905563 negative regulation of vascular endothelial cell proliferation; GO:1905809 negative regulation of synapse organization; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000331 regulation of terminal button organization; GO:2001141 regulation of RNA biosynthetic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005901 caveola; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0032991 protein-containing complex; GO:0033596 TSC1-TSC2 complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0044853 plasma membrane raft; GO:0045121 membrane raft; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098590 plasma membrane region; GO:0098857 membrane microdomain; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019902 phosphatase binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031072 heat shock protein binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0047485 protein N-terminus binding; GO:0051020 GTPase binding; GO:0051879 Hsp90 protein binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0071889 14-3-3 protein binding; GO:0098772 molecular function regulator;",null,null,"DT","KOG3687","Tuberin - Rap/ran-GTPase-activating protein","WP1403 AMPACTIVATED PROTEIN KINASE AMPK SIGNALING;WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE;WP3676 BDNFTRKB SIGNALING;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP4018 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP2035 FOLLICLE STIMULATING HORMONE FSH SIGNALING PATHWAY;WP4549 FRAGILE X SYNDROME;WP2261 GLIOBLASTOMA SIGNALING PATHWAYS;WP4674 HEAD AND NECK SQUAMOUS CELL CARCINOMA;WP481 INSULIN SIGNALING;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP727 MONOAMINE TRANSPORT;WP2509 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH;WP4577 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY;WP4172 PI3KAKT SIGNALING PATHWAY;WP3844 PI3KAKTMTOR SIGNALING PATHWAY AND THERAPEUTIC OPPORTUNITIES;WP4141 PI3KAKTMTOR VITD3 SIGNALING;WP4539 SYNAPTIC SIGNALING PATHWAYS ASSOCIATED WITH AUTISM SPECTRUM DISORDER;WP1471 TARGET OF RAPAMYCIN TOR SIGNALING;WP5098 TCELL ACTIVATION SARSCOV2;WP4321 THERMOGENESIS;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS;WP363 WNT SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP1403_r116516;http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP3878_r117656;http://www.wikipathways.org/instance/WP3676_r116809;http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP4018_r117168;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP2035_r120721;http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP2261_r118379;http://www.wikipathways.org/instance/WP4674_r117748;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP727_r116775;http://www.wikipathways.org/instance/WP2509_r101755;http://www.wikipathways.org/instance/WP4577_r118444;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP3844_r107714;http://www.wikipathways.org/instance/WP4141_r116420;http://www.wikipathways.org/instance/WP4539_r113659;http://www.wikipathways.org/instance/WP1471_r116793;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP4321_r106178;http://www.wikipathways.org/instance/WP4746_r120402;http://www.wikipathways.org/instance/WP363_r120695",null,"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-1632852 Macroautophagy;R-HSA-1643685 Disease;R-HSA-165159 MTOR signalling;R-HSA-165181 Inhibition of TSC complex formation by PKB;R-HSA-198323 AKT phosphorylates targets in the cytosol;R-HSA-199991 Membrane Trafficking;R-HSA-212436 Generic Transcription Pathway;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK;R-HSA-5628897 TP53 Regulates Metabolic Genes;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8854214 TBC/RABGAPs;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9007101 Rab regulation of trafficking;R-HSA-9612973 Autophagy","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-165159;https://reactome.org/PathwayBrowser/#/R-HSA-165181;https://reactome.org/PathwayBrowser/#/R-HSA-198323;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2219528;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-380972;https://reactome.org/PathwayBrowser/#/R-HSA-5628897;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-5674400;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8854214;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9007101;https://reactome.org/PathwayBrowser/#/R-HSA-9612973","MYOGENESIS;PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["P50238","Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3","CRIP1",1.140890193,0.628069346,"nochange",683.6,1229.62,772.737,1118.72,691.622,1254.04,0.713279687,1.283006098,0.806286725,1.167291181,0.721649976,1.308486334,"nucleus","K24412",null,null,"GO:0000003 reproduction; GO:0001655 urogenital system development; GO:0001738 morphogenesis of a polarized epithelium; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002376 immune system process; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006955 immune response; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007507 heart development; GO:0007548 sex differentiation; GO:0007586 digestion; GO:0007610 behavior; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010043 response to zinc ion; GO:0010171 body morphogenesis; GO:0010224 response to UV-B; GO:0010468 regulation of gene expression; GO:0012501 programmed cell death; GO:0018991 oviposition; GO:0019098 reproductive behavior; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0022600 digestive system process; GO:0022612 gland morphogenesis; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030850 prostate gland development; GO:0030855 epithelial cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033554 cellular response to stress; GO:0034644 cellular response to UV; GO:0035150 regulation of tube size; GO:0035556 intracellular signal transduction; GO:0042221 response to chemical; GO:0045138 nematode male tail tip morphogenesis; GO:0046661 male sex differentiation; GO:0046677 response to antibiotic; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060512 prostate gland morphogenesis; GO:0060741 prostate gland stromal morphogenesis; GO:0061448 connective tissue development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071236 cellular response to antibiotic; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071493 cellular response to UV-B; GO:0072359 circulatory system development; GO:0090066 regulation of anatomical structure size; GO:0090598 male anatomical structure morphogenesis; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0104004 cellular response to environmental stimulus;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003680 minor groove of adenine-thymine-rich DNA binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0008301 DNA binding"," bending; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00412","PF00412 LIM domain","TZ","KOG1700","Regulatory protein MLP and related LIM proteins"]
["P50542","Peroxisomal targeting signal 1 receptor OS=Homo sapiens OX=9606 GN=PEX5 PE=1 SV=3","PEX5",0.798609568,0.029493209,"nochange",8729.94,9206.16,9607.86,6550.94,7298.67,8147.26,1.057302431,1.114978493,1.163629273,0.793398899,0.883958141,0.986732762,"nucleus","K13342","PEX5; peroxin-5","hsa04146 Peroxisome","GO:0000038 very long-chain fatty acid metabolic process; GO:0001764 neuron migration; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003008 system process; GO:0006082 organic acid metabolic process; GO:0006464 cellular protein modification process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006625 protein targeting to peroxisome; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007029 endoplasmic reticulum organization; GO:0007031 peroxisome organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009791 post-embryonic development; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015919 peroxisomal membrane transport; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0016477 cell migration; GO:0016558 protein import into peroxisome matrix; GO:0016560 protein import into peroxisome matrix"," docking; GO:0016561 protein import into peroxisome matrix"," translocation; GO:0016567 protein ubiquitination; GO:0017038 protein import; GO:0019395 fatty acid oxidation; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021795 cerebral cortex cell migration; GO:0021885 forebrain cell migration; GO:0021895 cerebral cortex neuron differentiation; GO:0021953 central nervous system neuron differentiation; GO:0021987 cerebral cortex development; GO:0022008 neurogenesis; GO:0022029 telencephalon cell migration; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030258 lipid modification; GO:0030900 forebrain development; GO:0031333 negative regulation of protein-containing complex assembly; GO:0032446 protein modification by small protein conjugation; GO:0032459 regulation of protein oligomerization; GO:0032460 negative regulation of protein oligomerization; GO:0032462 regulation of protein homooligomerization; GO:0032463 negative regulation of protein homooligomerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034440 lipid oxidation; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043436 oxoacid metabolic process; GO:0043574 peroxisomal transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045046 protein import into peroxisome membrane; GO:0045184 establishment of protein localization; GO:0045927 positive regulation of growth; GO:0046395 carboxylic acid catabolic process; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051259 protein complex oligomerization; GO:0051262 protein tetramerization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0055085 transmembrane transport; GO:0060322 head development; GO:0061024 membrane organization; GO:0065002 intracellular protein transmembrane transport; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072329 monocarboxylic acid catabolic process; GO:0072347 response to anesthetic; GO:0072594 establishment of protein localization to organelle; GO:0072657 protein localization to membrane; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0090150 establishment of protein localization to membrane; GO:1901090 regulation of protein tetramerization; GO:1901091 negative regulation of protein tetramerization; GO:1901093 regulation of protein homotetramerization; GO:1901094 negative regulation of protein homotetramerization; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005782 peroxisomal matrix; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031903 microbody membrane; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;","GO:0000268 peroxisome targeting sequence binding; GO:0005048 signal sequence binding; GO:0005052 peroxisome matrix targeting signal-1 binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0047485 protein N-terminus binding; GO:0051020 GTPase binding;",null,null,"R","KOG1125","TPR repeat-containing protein",{"$nulls":3},"R-HSA-1632852 Macroautophagy;R-HSA-9612973 Autophagy;R-HSA-9663891 Selective autophagy;R-HSA-9664873 Pexophagy","https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9663891;https://reactome.org/PathwayBrowser/#/R-HSA-9664873","PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["P50995","Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1","ANXA11",0.850722776,0.006279384,"down",162548,161280,162837,136720,131326,145971,1.082832787,1.074385854,1.084757994,0.9107765,0.87484373,0.972403135,"cytoplasm","K17095","ANXA7_11; annexin A7/11","hsa05014 Amyotrophic lateral sclerosis","GO:0000910 cytokinesis; GO:0006810 transport; GO:0006811 ion transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0007049 cell cycle; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0032506 cytokinetic process; GO:0034220 ion transmembrane transport; GO:0042221 response to chemical; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051301 cell division; GO:0051592 response to calcium ion; GO:0055085 transmembrane transport; GO:0065003 protein-containing complex assembly; GO:0071840 cellular component organization or biogenesis; GO:0098657 import into cell;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005766 primary lysosome; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030139 endocytic vesicle; GO:0030141 secretory granule; GO:0030496 midbody; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0042470 melanosome; GO:0042581 specific granule; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045335 phagocytic vesicle; GO:0048770 pigment granule; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005488 binding; GO:0005496 steroid binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005525 GTP binding; GO:0005543 phospholipid binding; GO:0005544 calcium-dependent phospholipid binding; GO:0008289 lipid binding; GO:0008429 phosphatidylethanolamine binding; GO:0015075 ion transmembrane transporter activity; GO:0015267 channel activity; GO:0015276 ligand-gated ion channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015485 cholesterol binding; GO:0017076 purine nucleotide binding; GO:0019001 guanyl nucleotide binding; GO:0022803 passive transmembrane transporter activity; GO:0022834 ligand-gated channel activity; GO:0022836 gated channel activity; GO:0022839 ion gated channel activity; GO:0022857 transmembrane transporter activity; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0032934 sterol binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043178 alcohol binding; GO:0044548 S100 protein binding; GO:0046872 metal ion binding; GO:0046983 protein dimerization activity; GO:0048306 calcium-dependent protein binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00191","PF00191 Annexin","U","KOG0819","Annexin"]
["P51157","Ras-related protein Rab-28 OS=Homo sapiens OX=9606 GN=RAB28 PE=1 SV=2","RAB28",1.099335444,0.853650598,"nochange",1462.91,729.86,1265.18,952.908,874.609,1973.93,1.209116956,0.603240186,1.045690159,0.787592688,0.722877396,1.631482615,"cytoplasm","K07915",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0001578 microtubule bundle formation; GO:0003386 amphid sensory organ development; GO:0006810 transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0031344 regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0035082 axoneme assembly; GO:0035640 exploration behavior; GO:0035641 locomotory exploration behavior; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044782 cilium organization; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0060271 cilium assembly; GO:0060491 regulation of cell projection assembly; GO:0065007 biological regulation; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901998 toxin transport; GO:1902017 regulation of cilium assembly; GO:1902115 regulation of organelle assembly;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0005930 axoneme; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0032838 plasma membrane bounded cell projection cytoplasm; GO:0035253 ciliary rootlet; GO:0035869 ciliary transition zone; GO:0036064 ciliary basal body; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0071944 cell periphery; GO:0097014 ciliary plasm; GO:0097546 ciliary base; GO:0098590 plasma membrane region; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:1990075 periciliary membrane compartment;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005525 GTP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0019003 GDP binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00071","PF00071 Ras family","TU","KOG0078","GTP-binding protein SEC4"," small G protein superfamily"," and related Ras family GTP-binding proteins","WP4803 CILIOPATHIES","http://www.wikipathways.org/instance/WP4803_r110008"]
["P51608","Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2 PE=1 SV=1","MECP2",1.786973276,0.000110798,"up",32951.8,32165.2,31961.9,58721.1,60965.6,53790.7,0.730756593,0.713312534,0.708804046,1.302230257,1.352005479,1.192891091,"nucleus","K11588",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0001558 regulation of cell growth; GO:0001662 behavioral fear response; GO:0001666 response to hypoxia; GO:0001964 startle response; GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure; GO:0002087 regulation of respiratory gaseous exchange by nervous system process; GO:0002209 behavioral defense response; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003073 regulation of systemic arterial blood pressure; GO:0005975 carbohydrate metabolic process; GO:0006020 inositol metabolic process; GO:0006066 alcohol metabolic process; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006122 mitochondrial electron transport"," ubiquinol to cytochrome c; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006325 chromatin organization; GO:0006349 regulation of gene expression by genomic imprinting; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006479 protein methylation; GO:0006520 cellular amino acid metabolic process; GO:0006541 glutamine metabolic process; GO:0006576 cellular biogenic amine metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0007585 respiratory gaseous exchange by respiratory system; GO:0007600 sensory perception; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007613 memory; GO:0007616 long-term memory; GO:0007626 locomotory behavior; GO:0007632 visual behavior; GO:0008015 blood circulation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008211 glucocorticoid metabolic process; GO:0008213 protein alkylation; GO:0008217 regulation of blood pressure; GO:0008284 positive regulation of cell population proliferation; GO:0008306 associative learning; GO:0008344 adult locomotory behavior; GO:0008542 visual learning; GO:0009064 glutamine family amino acid metabolic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009308 amine metabolic process; GO:0009314 response to radiation; GO:0009410 response to xenobiotic stimulus; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010288 response to lead ion; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010594 regulation of endothelial cell migration; GO:0010596 negative regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010633 negative regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010817 regulation of hormone levels; GO:0010941 regulation of cell death; GO:0010968 regulation of microtubule nucleation; GO:0010971 positive regulation of G2/M transition of mitotic cell cycle; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0014003 oligodendrocyte development; GO:0014013 regulation of gliogenesis; GO:0014014 negative regulation of gliogenesis; GO:0014070 response to organic cyclic compound; GO:0014072 response to isoquinoline alkaloid; GO:0015844 monoamine transport; GO:0015850 organic hydroxy compound transport; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016358 dendrite development; GO:0016525 negative regulation of angiogenesis; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019230 proprioception; GO:0019233 sensory perception of pain; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019751 polyol metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0021510 spinal cord development; GO:0021536 diencephalon development; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021544 subpallium development; GO:0021549 cerebellum development; GO:0021591 ventricular system development; GO:0021700 developmental maturation; GO:0021730 trigeminal sensory nucleus development; GO:0021740 principal sensory nucleus of trigeminal nerve development; GO:0021756 striatum development; GO:0021761 limbic system development; GO:0021766 hippocampus development; GO:0021772 olfactory bulb development; GO:0021782 glial cell development; GO:0021794 thalamus development; GO:0021987 cerebral cortex development; GO:0021988 olfactory lobe development; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0022402 cell cycle process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030308 negative regulation of cell growth; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030534 adult behavior; GO:0030900 forebrain development; GO:0030902 hindbrain development; GO:0031056 regulation of histone modification; GO:0031057 negative regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031061 negative regulation of histone methylation; GO:0031062 positive regulation of histone methylation; GO:0031110 regulation of microtubule polymerization or depolymerization; GO:0031112 positive regulation of microtubule polymerization or depolymerization; GO:0031113 regulation of microtubule polymerization; GO:0031116 positive regulation of microtubule polymerization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031915 positive regulation of synaptic plasticity; GO:0032048 cardiolipin metabolic process; GO:0032091 negative regulation of protein binding; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032355 response to estradiol; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033555 multicellular organismal response to stress; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0035065 regulation of histone acetylation; GO:0035067 negative regulation of histone acetylation; GO:0035176 social behavior; GO:0035295 tube development; GO:0035864 response to potassium ion; GO:0035865 cellular response to potassium ion; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0040008 regulation of growth; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0042063 gliogenesis; GO:0042127 regulation of cell population proliferation; GO:0042220 response to cocaine; GO:0042221 response to chemical; GO:0042391 regulation of membrane potential; GO:0042445 hormone metabolic process; GO:0042551 neuron maturation; GO:0042596 fear response; GO:0042692 muscle cell differentiation; GO:0042773 ATP synthesis coupled electron transport; GO:0042775 mitochondrial ATP synthesis coupled electron transport; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043279 response to alkaloid; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043436 oxoacid metabolic process; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0043537 negative regulation of blood vessel endothelial cell migration; GO:0043543 protein acylation; GO:0043576 regulation of respiratory gaseous exchange; GO:0044030 regulation of DNA methylation; GO:0044057 regulation of system process; GO:0044065 regulation of respiratory system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044106 cellular amine metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045333 cellular respiration; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045685 regulation of glial cell differentiation; GO:0045686 negative regulation of glial cell differentiation; GO:0045765 regulation of angiogenesis; GO:0045787 positive regulation of cell cycle; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045931 positive regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046034 ATP metabolic process; GO:0046470 phosphatidylcholine metabolic process; GO:0046471 phosphatidylglycerol metabolic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046903 secretion; GO:0048167 regulation of synaptic plasticity; GO:0048286 lung alveolus development; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048709 oligodendrocyte differentiation; GO:0048710 regulation of astrocyte differentiation; GO:0048712 negative regulation of astrocyte differentiation; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048857 neural nucleus development; GO:0048869 cellular developmental process; GO:0050432 catecholamine secretion; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050808 synapse organization; GO:0050877 nervous system process; GO:0050884 neuromuscular process controlling posture; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051145 smooth muscle cell differentiation; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051150 regulation of smooth muscle cell differentiation; GO:0051151 negative regulation of smooth muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051570 regulation of histone H3-K9 methylation; GO:0051574 positive regulation of histone H3-K9 methylation; GO:0051703 biological process involved in intraspecies interaction between organisms; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051937 catecholamine transport; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060078 regulation of postsynaptic membrane potential; GO:0060079 excitatory postsynaptic potential; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060149 negative regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060291 long-term synaptic potentiation; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060359 response to ammonium ion; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0060632 regulation of microtubule-based movement; GO:0060688 regulation of morphogenesis of a branching structure; GO:0060964 regulation of gene silencing by miRNA; GO:0060965 negative regulation of gene silencing by miRNA; GO:0060966 regulation of gene silencing by RNA; GO:0060967 negative regulation of gene silencing by RNA; GO:0060998 regulation of dendritic spine development; GO:0060999 positive regulation of dendritic spine development; GO:0061000 negative regulation of dendritic spine development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070482 response to oxygen levels; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070887 cellular response to chemical stimulus; GO:0070920 regulation of production of small RNA involved in gene silencing by RNA; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071310 cellular response to organic substance; GO:0071312 cellular response to alkaloid; GO:0071317 cellular response to isoquinoline alkaloid; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071514 genomic imprinting; GO:0071695 anatomical structure maturation; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072347 response to anesthetic; GO:0072359 circulatory system development; GO:0072521 purine-containing compound metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090063 positive regulation of microtubule nucleation; GO:0090068 positive regulation of cell cycle process; GO:0097164 ammonium ion metabolic process; GO:0098916 anterograde trans-synaptic signaling; GO:0099177 regulation of trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099565 chemical synaptic transmission"," postsynaptic; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1900112 regulation of histone H3-K9 trimethylation; GO:1900114 positive regulation of histone H3-K9 trimethylation; GO:1901135 carbohydrate derivative metabolic process; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901605 alpha-amino acid metabolic process; GO:1901608 regulation of vesicle transport along microtubule; GO:1901610 positive regulation of vesicle transport along microtubule; GO:1901615 organic hydroxy compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901951 regulation of anterograde dense core granule transport; GO:1901953 positive regulation of anterograde dense core granule transport; GO:1901954 regulation of retrograde dense core granule transport; GO:1901956 positive regulation of retrograde dense core granule transport; GO:1901983 regulation of protein acetylation; GO:1901984 negative regulation of protein acetylation; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902275 regulation of chromatin organization; GO:1902513 regulation of organelle transport along microtubule; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902751 positive regulation of cell cycle G2/M phase transition; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903649 regulation of cytoplasmic transport; GO:1903651 positive regulation of cytoplasmic transport; GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA; GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA; GO:1903859 regulation of dendrite extension; GO:1903860 negative regulation of dendrite extension; GO:1903861 positive regulation of dendrite extension; GO:1904809 regulation of dense core granule transport; GO:1904811 positive regulation of dense core granule transport; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:1905268 negative regulation of chromatin organization; GO:1905269 positive regulation of chromatin organization; GO:1905492 positive regulation of branching morphogenesis of a nerve; GO:1905643 positive regulation of DNA methylation; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000171 negative regulation of dendrite development; GO:2000172 regulation of branching morphogenesis of a nerve; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2000634 regulation of primary miRNA processing; GO:2000635 negative regulation of primary miRNA processing; GO:2000756 regulation of peptidyl-lysine acetylation; GO:2000757 negative regulation of peptidyl-lysine acetylation; GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; GO:2001017 regulation of retrograde axon cargo transport; GO:2001019 positive regulation of retrograde axon cargo transport; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008327 methyl-CpG binding; GO:0010385 double-stranded methylated DNA binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031490 chromatin DNA binding; GO:0035197 siRNA binding; GO:0036094 small molecule binding; GO:0042826 histone deacetylase binding; GO:0043565 sequence-specific DNA binding; GO:0045322 unmethylated CpG binding; GO:0047485 protein N-terminus binding; GO:0061980 regulatory RNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990841 promoter-specific chromatin binding;","PF01429","PF01429 Methyl-CpG binding domain","KB","KOG4161","Methyl-CpG binding transcription regulators","WP3585 CYTOSINE METHYLATION;WP2858 ECTODERM DIFFERENTIATION;WP4549 FRAGILE X SYNDROME;WP3624 LUNG FIBROSIS;WP3584 MECP2 AND ASSOCIATED RETT SYNDROME;WP4577 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY;WP4312 RETT SYNDROME CAUSING GENES;WP706 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS;WP4533 TRANSCRIPTION COFACTORS SKI AND SKIL PROTEIN PARTNERS","http://www.wikipathways.org/instance/WP3585_r106742;http://www.wikipathways.org/instance/WP2858_r116763;http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP3624_r118417;http://www.wikipathways.org/instance/WP3584_r117155;http://www.wikipathways.org/instance/WP4577_r118444;http://www.wikipathways.org/instance/WP4312_r119230;http://www.wikipathways.org/instance/WP706_r117178;http://www.wikipathways.org/instance/WP4533_r103380","Transcription factor"]
["P51668","Ubiquitin-conjugating enzyme E2 D1 OS=Homo sapiens OX=9606 GN=UBE2D1 PE=1 SV=1","UBE2D1",0.854159982,0.042450742,"nochange",15517,14950.5,15035.1,14286.7,11914.9,12664.9,1.103508275,1.063221013,1.069237434,1.016014157,0.847341029,0.900678092,"cytoplasm","K06689","UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]","hsa04120 Ubiquitin mediated proteolysis; hsa04141 Protein processing in endoplasmic reticulum; hsa05131 Shigellosis","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000209 protein polyubiquitination; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016567 protein ubiquitination; GO:0016579 protein deubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0023052 signaling; GO:0030163 protein catabolic process; GO:0030509 BMP signaling pathway; GO:0031145 anaphase-promoting complex-dependent catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043574 peroxisomal transport; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0070936 protein K48-linked ubiquitination; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071772 response to BMP; GO:0071773 cellular response to BMP stimulus; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902914 regulation of protein polyubiquitination; GO:1902916 positive regulation of protein polyubiquitination; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0061631 ubiquitin conjugating enzyme activity; GO:0061650 ubiquitin-like protein conjugating enzyme activity; GO:0140096 catalytic activity"," acting on a protein;","PF00179","PF00179 Ubiquitin-conjugating enzyme","O","KOG0417","Ubiquitin-protein ligase","WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components;R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-168927 TICAM1"," RIP1-mediated IKK complex recruitment;R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176412 Phosphorylation of the APC/C;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-201451 Signaling by BMP;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-212436 Generic Transcription Pathway;R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer;R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP);R-HSA-2559583 Cellular Senescence;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-392499 Metabolism of proteins;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5688426 Deubiquitination;R-HSA-5689896 Ovarian tumor domain proteases;R-HSA-597592 Post-translational protein modification;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8852135 Protein ubiquitination;R-HSA-8853884 Transcriptional Regulation by VENTX;R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins;R-HSA-8951664 Neddylation;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006936 Signaling by TGFB family members;R-HSA-9033241 Peroxisomal protein import;R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling;R-HSA-937041 IKK complex recruitment mediated by RIP1;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-9609507 Protein localization;R-HSA-9674555 Signaling by CSF3 (G-CSF);R-HSA-9675126 Diseases of mitotic cell cycle;R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects;R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects;R-HSA-9705462 Inactivation of CSF3 (G-CSF) signaling;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation",null,"ALLOGRAFT REJECTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION"]
["P52292","Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1","KPNA2",2.163364409,{"v":4.32963e-06,"d":"4.33E-06"},"up",40287.7,40158.1,40229.2,87090.1,90372.1,83601.8,0.633223747,0.631186753,0.632304271,1.368842586,1.42042757,1.314015073,"cytoplasm","nucleus","K15043","KPNA2_7; importin subunit alpha-1/8","hsa03013 Nucleocytoplasmic transport; hsa05164 Influenza A; hsa05207 Chemical carcinogenesis - receptor activation","GO:0000003 reproduction; GO:0000018 regulation of DNA recombination; GO:0000278 mitotic cell cycle; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006998 nuclear envelope organization; GO:0007049 cell cycle; GO:0007084 mitotic nuclear membrane reassembly; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007291 sperm individualization; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007300 ovarian nurse cell to oocyte transport; GO:0007301 female germline ring canal formation; GO:0007349 cellularization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009629 response to gravity; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0019048 modulation by virus of host process; GO:0019054 modulation by virus of host cellular process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0030725 germline ring canal formation; GO:0031323 regulation of cellular metabolic process; GO:0031468 nuclear membrane reassembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035821 modulation of process of another organism; GO:0040011 locomotion; GO:0042330 taxis; GO:0042332 gravitaxis; GO:0042886 amide transport; GO:0043062 extracellular structure organization; GO:0043063 intercellular bridge organization; GO:0043170 macromolecule metabolic process; GO:0044003 modulation by symbiont of host process; GO:0044068 modulation by symbiont of host cellular process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048534 hematopoietic or lymphoid organ development; GO:0048542 lymph gland development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051701 biological process involved in interaction with host; GO:0051983 regulation of chromosome segregation; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903047 mitotic cell cycle process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0010494 cytoplasmic stress granule; GO:0012505 endomembrane system; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0005048 signal sequence binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008139 nuclear localization sequence binding; GO:0019899 enzyme binding; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0042826 histone deacetylase binding;",null,null,"U","KOG0166","Karyopherin (importin) alpha",{"$nulls":3},"R-HSA-111885 Opioid Signalling;R-HSA-111932 CaMK IV-mediated phosphorylation of CREB;R-HSA-111933 Calmodulin induced events;R-HSA-111996 Ca-dependent events;R-HSA-111997 CaM pathway;R-HSA-112040 G-protein mediated events;R-HSA-112043 PLC beta mediated events;R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission;R-HSA-112315 Transmission across Chemical Synapses;R-HSA-112316 Neuronal System;R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1489509 DAG and IP3 signaling;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168276 NS1 Mediated Effects on Host Pathways;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-418594 G alpha (i) signalling events;R-HSA-438064 Post NMDA receptor activation events;R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;R-HSA-442755 Activation of NMDA receptors and postsynaptic events;R-HSA-5663205 Infectious disease;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693548 Sensing of DNA Double Strand Breaks;R-HSA-5693606 DNA Double Strand Break Response;R-HSA-73894 DNA Repair;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9018519 Estrogen-dependent gene expression;R-HSA-913531 Interferon Signaling;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions","https://reactome.org/PathwayBrowser/#/R-HSA-111885;https://reactome.org/PathwayBrowser/#/R-HSA-111932;https://reactome.org/PathwayBrowser/#/R-HSA-111933;https://reactome.org/PathwayBrowser/#/R-HSA-111996;https://reactome.org/PathwayBrowser/#/R-HSA-111997;https://reactome.org/PathwayBrowser/#/R-HSA-112040;https://reactome.org/PathwayBrowser/#/R-HSA-112043;https://reactome.org/PathwayBrowser/#/R-HSA-112314;https://reactome.org/PathwayBrowser/#/R-HSA-112315;https://reactome.org/PathwayBrowser/#/R-HSA-112316;https://reactome.org/PathwayBrowser/#/R-HSA-1169408;https://reactome.org/PathwayBrowser/#/R-HSA-1169410;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1489509;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168276;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-418594;https://reactome.org/PathwayBrowser/#/R-HSA-438064;https://reactome.org/PathwayBrowser/#/R-HSA-442729;https://reactome.org/PathwayBrowser/#/R-HSA-442755;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693548;https://reactome.org/PathwayBrowser/#/R-HSA-5693606;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-9006925;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9018519;https://reactome.org/PathwayBrowser/#/R-HSA-913531;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9705671;https://reactome.org/PathwayBrowser/#/R-HSA-9705683","E2F TARGETS;G2M CHECKPOINT;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["P52435","DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1","POLR2J",0.990140204,0.864161425,"nochange",11663,12285.9,12968.7,13801.4,10889.6,11862.6,0.952454839,1.003323751,1.059084376,1.127086532,0.889295397,0.968755104,"cytoplasm","K03008","RPB11; DNA-directed RNA polymerase II subunit RPB11","hsa05016 Huntington disease; hsa03020 RNA polymerase","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006354 DNA-templated transcription"," elongation; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0008543 fibroblast growth factor receptor signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009301 snRNA transcription; GO:0009452 7-methylguanosine RNA capping; GO:0009719 response to endogenous stimulus; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016073 snRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023052 signaling; GO:0032774 RNA biosynthetic process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0036260 RNA capping; GO:0042221 response to chemical; GO:0042795 snRNA transcription by RNA polymerase II; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044344 cellular response to fibroblast growth factor stimulus; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060964 regulation of gene silencing by miRNA; GO:0060966 regulation of gene silencing by RNA; GO:0065007 biological regulation; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071774 response to fibroblast growth factor; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098781 ncRNA transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005665 RNA polymerase II"," core complex; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0003899 DNA-directed 5'-3' RNA polymerase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0019904 protein domain specific binding; GO:0030275 LRR domain binding; GO:0034062 5'-3' RNA polymerase activity; GO:0097747 RNA polymerase activity; GO:0140098 catalytic activity"," acting on RNA;","PF13656","PF13656 RNA polymerase Rpb3/Rpb11 dimerisation domain","K","KOG4392","RNA polymerase"," subunit L","WP405 EUKARYOTIC TRANSCRIPTION INITIATION;WP4022 PYRIMIDINE METABOLISM","http://www.wikipathways.org/instance/WP405_r118377;http://www.wikipathways.org/instance/WP4022_r120306",null,"R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-113418 Formation of the Early Elongation Complex;R-HSA-1226099 Signaling by FGFR in disease;R-HSA-1266738 Developmental Biology;R-HSA-157579 Telomere Maintenance;R-HSA-162582 Signal Transduction;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167158 Formation of the HIV-1 Early Elongation Complex;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167161 HIV Transcription Initiation;R-HSA-167162 RNA Polymerase II HIV Promoter Escape;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation;R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat;R-HSA-167243 Tat-mediated HIV elongation arrest and recovery;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-167287 HIV elongation arrest and recovery;R-HSA-167290 Pausing and recovery of HIV elongation;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-168325 Viral Messenger RNA Synthesis;R-HSA-1839126 FGFR2 mutant receptor activation;R-HSA-190236 Signaling by FGFR;R-HSA-203927 MicroRNA (miRNA) biogenesis;R-HSA-211000 Gene Silencing by RNA;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-5654738 Signaling by FGFR2;R-HSA-5655253 Signaling by FGFR2 in disease;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6803529 FGFR2 alternative splicing;R-HSA-6807505 RNA polymerase II transcribes snRNA genes;R-HSA-72086 mRNA Capping;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72165 mRNA Splicing - Minor Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73776 RNA Polymerase II Promoter Escape;R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73886 Chromosome Maintenance;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-75953 RNA Polymerase II Transcription Initiation;R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance;R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8851708 Signaling by FGFR2 IIIa TM;R-HSA-8939211 ESR-mediated signaling;R-HSA-8953854 Metabolism of RNA;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9018519 Estrogen-dependent gene expression;R-HSA-9670095 Inhibition of DNA recombination at telomere",null,"DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["P52758","2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1","RIDA",0.807182479,0.131682167,"nochange",9208.92,7440.93,7528.71,5483.62,7542.92,6489.97,1.264525266,1.021753255,1.033806789,0.752984719,1.035758039,0.891171933,"mitochondria","K09022",null,null,"GO:0001505 regulation of neurotransmitter levels; GO:0001655 urogenital system development; GO:0001822 kidney development; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006417 regulation of translation; GO:0006457 protein folding; GO:0006520 cellular amino acid metabolic process; GO:0006544 glycine metabolic process; GO:0006566 threonine metabolic process; GO:0006567 threonine catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009063 cellular amino acid catabolic process; GO:0009066 aspartate family amino acid metabolic process; GO:0009068 aspartate family amino acid catabolic process; GO:0009069 serine family amino acid metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016054 organic acid catabolic process; GO:0016070 RNA metabolic process; GO:0017148 negative regulation of translation; GO:0019222 regulation of metabolic process; GO:0019518 L-threonine catabolic process to glycine; GO:0019752 carboxylic acid metabolic process; GO:0022402 cell cycle process; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033993 response to lipid; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0035295 tube development; GO:0042127 regulation of cell population proliferation; GO:0042133 neurotransmitter metabolic process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050678 regulation of epithelial cell proliferation; GO:0050680 negative regulation of epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060541 respiratory system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070314 G1 to G0 transition; GO:0071704 organic substance metabolic process; GO:0072001 renal system development; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090502 RNA phosphodiester bond hydrolysis"," endonucleolytic; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901605 alpha-amino acid metabolic process; GO:1901606 alpha-amino acid catabolic process; GO:1902074 response to salt; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005777 peroxisome; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0004521 endoribonuclease activity; GO:0004540 ribonuclease activity; GO:0005488 binding; GO:0005504 fatty acid binding; GO:0005515 protein binding; GO:0008289 lipid binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016892 endoribonuclease activity"," producing 3'-phosphomonoesters; GO:0016894 endonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters; GO:0019239 deaminase activity; GO:0031406 carboxylic acid binding; GO:0033293 monocarboxylic acid binding; GO:0036041 long-chain fatty acid binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043177 organic acid binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046983 protein dimerization activity; GO:0140098 catalytic activity"," acting on RNA;","PF01042","PF01042 Endoribonuclease L-PSP","J","KOG2317","Putative translation initiation inhibitor UK114/IBM1",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-8849175 Threonine catabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-8849175"]
["P53004","Biliverdin reductase A OS=Homo sapiens OX=9606 GN=BLVRA PE=1 SV=2","BLVRA",1.077944168,6.42262E-4,"nochange",239015,235185,240119,255839,255179,258978,0.966162843,0.950680954,0.970625507,1.034169971,1.031502073,1.046858652,"cytoplasm","K00214","BLVRA; biliverdin reductase [EC:1.3.1.24]","hsa00860 Porphyrin metabolism; hsa01100 Metabolic pathways","GO:0006725 cellular aromatic compound metabolic process; GO:0006778 porphyrin-containing compound metabolic process; GO:0006787 porphyrin-containing compound catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009987 cellular process; GO:0019439 aromatic compound catabolic process; GO:0033013 tetrapyrrole metabolic process; GO:0033015 tetrapyrrole catabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042167 heme catabolic process; GO:0042168 heme metabolic process; GO:0042440 pigment metabolic process; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0046149 pigment catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0071704 organic substance metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004074 biliverdin reductase (NAD(P)+) activity; GO:0005488 binding; GO:0016491 oxidoreductase activity; GO:0016627 oxidoreductase activity"," acting on the CH-CH group of donors; GO:0016628 oxidoreductase activity"," acting on the CH-CH group of donors"," NAD or NADP as acceptor; GO:0036094 small molecule binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF09166","PF09166 Biliverdin reductase"," catalytic",{"$nulls":3},"WP4495 IL10 ANTIINFLAMMATORY SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4495_r117759",null,"R-HSA-1430728 Metabolism;R-HSA-189445 Metabolism of porphyrins;R-HSA-189483 Heme degradation;R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-189445;https://reactome.org/PathwayBrowser/#/R-HSA-189483;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9711123","FATTY ACID METABOLISM;HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["P53621","Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2","COPA",0.765398527,0.000161326,"down",141621,140566,143292,111510,104718,109433,1.131248502,1.122821312,1.144596214,0.890726096,0.836472562,0.874135314,"cytoplasm","K05236",null,null,"GO:0000003 reproduction; GO:0000280 nuclear division; GO:0000902 cell morphogenesis; GO:0000910 cytokinesis; GO:0003008 system process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006891 intra-Golgi vesicle-mediated transport; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007112 male meiosis cytokinesis; GO:0007140 male meiotic nuclear division; GO:0007276 gamete generation; GO:0007586 digestion; GO:0007589 body fluid secretion; GO:0008104 protein localization; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010883 regulation of lipid storage; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022600 digestive system process; GO:0030157 pancreatic juice secretion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032941 secretion by tissue; GO:0032989 cellular component morphogenesis; GO:0033036 macromolecule localization; GO:0033206 meiotic cytokinesis; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050878 regulation of body fluid levels; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072741 protein localization to cell division site; GO:0140013 meiotic nuclear division; GO:1903046 meiotic cell cycle process; GO:1905345 protein localization to cleavage furrow; GO:1905952 regulation of lipid localization; GO:1990778 protein localization to cell periphery;","GO:0000139 Golgi membrane; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030120 vesicle coat; GO:0030126 COPI vesicle coat; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030137 COPI-coated vesicle; GO:0030659 cytoplasmic vesicle membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030663 COPI-coated vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048475 coated membrane; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;",{"$nulls":3},"U","KOG0292","Vesicle coat complex COPI"," alpha subunit",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-948021","EPITHELIAL MESENCHYMAL TRANSITION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"]
["P54132","RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1","BLM",0.688151939,1.102233E-3,"down",13551.8,13136.3,12393.4,8717.09,8560.95,9615.97,1.232439128,1.194652379,1.127090946,0.792756888,0.778557074,0.874503585,"nucleus","K10901","BLM; bloom syndrome protein [EC:5.6.2.4]","hsa03460 Fanconi anemia pathway; hsa03440 Homologous recombination","GO:0000003 reproduction; GO:0000018 regulation of DNA recombination; GO:0000019 regulation of mitotic recombination; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000729 DNA double-strand break processing; GO:0000731 DNA synthesis involved in DNA repair; GO:0000732 strand displacement; GO:0001325 formation of extrachromosomal circular DNA; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006275 regulation of DNA replication; GO:0006281 DNA repair; GO:0006282 regulation of DNA repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006310 DNA recombination; GO:0006355 regulation of transcription"," DNA-templated; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007095 mitotic G2 DNA damage checkpoint signaling; GO:0007127 meiosis I; GO:0007131 reciprocal meiotic recombination; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008156 negative regulation of DNA replication; GO:0008284 positive regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010165 response to X-ray; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010569 regulation of double-strand break repair via homologous recombination; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022402 cell cycle process; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030217 T cell differentiation; GO:0031297 replication fork processing; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031570 DNA integrity checkpoint signaling; GO:0032200 telomere organization; GO:0032268 regulation of cellular protein metabolic process; GO:0032392 DNA geometric change; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032508 DNA duplex unwinding; GO:0032944 regulation of mononuclear cell proliferation; GO:0032946 positive regulation of mononuclear cell proliferation; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035825 homologous recombination; GO:0042102 positive regulation of T cell proliferation; GO:0042110 T cell activation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043279 response to alkaloid; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044806 G-quadruplex DNA unwinding; GO:0044818 mitotic G2/M transition checkpoint; GO:0045003 double-strand break repair via synthesis-dependent strand annealing; GO:0045005 DNA-dependent DNA replication maintenance of fidelity; GO:0045321 leukocyte activation; GO:0045738 negative regulation of DNA repair; GO:0045739 positive regulation of DNA repair; GO:0045785 positive regulation of cell adhesion; GO:0045786 negative regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045910 negative regulation of DNA recombination; GO:0045911 positive regulation of DNA recombination; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045950 negative regulation of mitotic recombination; GO:0046483 heterocycle metabolic process; GO:0046631 alpha-beta T cell activation; GO:0046632 alpha-beta T cell differentiation; GO:0046634 regulation of alpha-beta T cell activation; GO:0046635 positive regulation of alpha-beta T cell activation; GO:0046640 regulation of alpha-beta T cell proliferation; GO:0046641 positive regulation of alpha-beta T cell proliferation; GO:0046649 lymphocyte activation; GO:0048285 organelle fission; GO:0048478 replication fork protection; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050670 regulation of lymphocyte proliferation; GO:0050671 positive regulation of lymphocyte proliferation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051098 regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051276 chromosome organization; GO:0051302 regulation of cell division; GO:0051321 meiotic cell cycle; GO:0051338 regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051782 negative regulation of cell division; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061820 telomeric D-loop disassembly; GO:0061982 meiosis I cell cycle process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070228 regulation of lymphocyte apoptotic process; GO:0070229 negative regulation of lymphocyte apoptotic process; GO:0070232 regulation of T cell apoptotic process; GO:0070233 negative regulation of T cell apoptotic process; GO:0070243 regulation of thymocyte apoptotic process; GO:0070244 negative regulation of thymocyte apoptotic process; GO:0070663 regulation of leukocyte proliferation; GO:0070665 positive regulation of leukocyte proliferation; GO:0070887 cellular response to chemical stimulus; GO:0071103 DNA conformation change; GO:0071214 cellular response to abiotic stimulus; GO:0071241 cellular response to inorganic substance; GO:0071310 cellular response to organic substance; GO:0071312 cellular response to alkaloid; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0072710 response to hydroxyurea; GO:0072711 cellular response to hydroxyurea; GO:0072757 cellular response to camptothecin; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0090329 regulation of DNA-dependent DNA replication; GO:0090656 t-circle formation; GO:0090657 telomeric loop disassembly; GO:0090737 telomere maintenance via telomere trimming; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097327 response to antineoplastic agent; GO:0097329 response to antimetabolite; GO:0104004 cellular response to environmental stimulus; GO:0140013 meiotic nuclear division; GO:1901291 negative regulation of double-strand break repair via single-strand annealing; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901563 response to camptothecin; GO:1901576 organic substance biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1905168 positive regulation of double-strand break repair via homologous recombination; GO:1990414 replication-born double-strand break repair via sister chromatid exchange; GO:1990918 double-strand break repair involved in meiotic recombination; GO:2000104 negative regulation of DNA-dependent DNA replication; GO:2000106 regulation of leukocyte apoptotic process; GO:2000107 negative regulation of leukocyte apoptotic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000779 regulation of double-strand break repair; GO:2000780 negative regulation of double-strand break repair; GO:2000781 positive regulation of double-strand break repair; GO:2001020 regulation of response to DNA damage stimulus; GO:2001021 negative regulation of response to DNA damage stimulus; GO:2001022 positive regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000781 chromosome"," telomeric region; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000795 synaptonemal complex; GO:0000800 lateral element; GO:0001673 male germ cell nucleus; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005657 replication fork; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016363 nuclear matrix; GO:0016604 nuclear body; GO:0016605 PML body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0034399 nuclear periphery; GO:0043073 germ cell nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045120 pronucleus; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:0099086 synaptonemal structure;","GO:0000166 nucleotide binding; GO:0000217 DNA secondary structure binding; GO:0000400 four-way junction DNA binding; GO:0000403 Y-form DNA binding; GO:0000405 bubble DNA binding; GO:0002039 p53 binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003678 DNA helicase activity; GO:0003684 damaged DNA binding; GO:0003697 single-stranded DNA binding; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0008270 zinc ion binding; GO:0009378 four-way junction helicase activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032356 oxidized DNA binding; GO:0032357 oxidized purine DNA binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0036310 ATP-dependent DNA/DNA annealing activity; GO:0042162 telomeric DNA binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043138 3'-5' DNA helicase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046983 protein dimerization activity; GO:0051880 G-quadruplex DNA binding; GO:0061749 forked DNA-dependent helicase activity; GO:0061821 telomeric D-loop binding; GO:0061849 telomeric G-quadruplex DNA binding; GO:0062037 D-loop DNA binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding;","PF08072; PF00270; PF00271; PF16124; PF09382; PF00570","PF08072 BDHCT (NUC031) domain; PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain; PF16124 RecQ zinc-binding; PF09382 RQC domain; PF00570 HRDC domain","L","KOG0351","ATP-dependent DNA helicase","WP3959 DNA IRDOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM;WP1971 INTEGRATED CANCER PATHWAY","http://www.wikipathways.org/instance/WP3959_r118468;http://www.wikipathways.org/instance/WP1971_r117762",null,"R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-174414 Processive synthesis on the C-strand of the telomere;R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis;R-HSA-180786 Extension of Telomeres;R-HSA-212436 Generic Transcription Pathway;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-392499 Metabolism of proteins;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5685938 HDR through Single Strand Annealing (SSA);R-HSA-5685942 HDR through Homologous Recombination (HRR);R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693537 Resolution of D-Loop Structures;R-HSA-5693538 Homology Directed Repair;R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA);R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates;R-HSA-5693579 Homologous DNA Pairing and Strand Exchange;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange;R-HSA-597592 Post-translational protein modification;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73886 Chromosome Maintenance;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-912446 Meiotic recombination;R-HSA-9675135 Diseases of DNA repair;R-HSA-9675136 Diseases of DNA Double-Strand Break Repair;R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function;R-HSA-9701192 Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function;R-HSA-9701193 Defective HDR through Homologous Recombination (HRR) due to PALB2 loss of function;R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function;R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function;R-HSA-9709570 Impaired BRCA2 binding to RAD51;R-HSA-9709603 Impaired BRCA2 binding to PALB2"]
["P54277","PMS1 protein homolog 1 OS=Homo sapiens OX=9606 GN=PMS1 PE=1 SV=1","PMS1",0.516582625,{"v":3.48374E-5,"d":"3.48E-05"},"down",12012.7,12438,11146.8,6114.23,6104.92,6169.9,1.335076978,1.382344306,1.238841897,0.679528142,0.67849344,0.685715238,"nucleus","K10864",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006298 mismatch repair; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0032300 mismatch repair complex; GO:0032389 MutLalpha complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1990391 DNA repair complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003697 single-stranded DNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF13589; PF00505","PF13589 Histidine kinase-"," DNA gyrase B-"," and HSP90-like ATPase; PF00505 HMG (high mobility group) box","L","KOG1978","DNA mismatch repair protein - MLH2/PMS1/Pms2 family"]
["P55010","Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2","EIF5",1.119710701,0.017581193,"nochange",48626.6,50336.4,53198,55682.9,58172.7,56520.7,0.904576308,0.936382862,0.989615775,1.035841126,1.08215763,1.0514263,"nucleus","K03262",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001731 formation of translation preinitiation complex; GO:0002181 cytoplasmic translation; GO:0002183 cytoplasmic translational initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006412 translation; GO:0006413 translational initiation; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0034248 regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043547 positive regulation of GTPase activity; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090630 activation of GTPase activity; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003743 translation initiation factor activity; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017111 nucleoside-triphosphatase activity; GO:0031369 translation initiation factor binding; GO:0071074 eukaryotic initiation factor eIF2 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG2767","Translation initiation factor 5 (eIF-5)","WP5027 NSP1 FROM SARSCOV2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL;WP107 TRANSLATION FACTORS","http://www.wikipathways.org/instance/WP5027_r120060;http://www.wikipathways.org/instance/WP107_r117851",null,"R-HSA-392499 Metabolism of proteins;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72702;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72766","UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["P55081","Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2","MFAP1",1.243696807,0.011420371,"nochange",49073.4,55945.8,49934,60956.7,66948.2,64809.9,0.846901067,0.965503872,0.861753167,1.0519812,1.155381571,1.118479124,"nucleus","K13110",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010564 regulation of cell cycle process; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1903311 regulation of mRNA metabolic process;","GO:0001527 microfibril; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0031012 extracellular matrix; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"Z","KOG1425","Microfibrillar-associated protein MFAP1","WP3845 CANONICAL AND NONCANONICAL NOTCH SIGNALING;WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP3845_r116460;http://www.wikipathways.org/instance/WP4352_r102218"]
["P55273","Cyclin-dependent kinase 4 inhibitor D OS=Homo sapiens OX=9606 GN=CDKN2D PE=1 SV=1","CDKN2D",1.551567747,0.013142314,"nochange",4862.38,5202.1,4763.49,6367.08,8921.84,7717.68,0.771101138,0.824975677,0.755418655,1.009724176,1.414871109,1.223909245,"cytoplasm","K06623","CDKN2D; cyclin-dependent kinase inhibitor 2D","hsa04110 Cell cycle; hsa04068 FoxO signaling pathway","GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000731 DNA synthesis involved in DNA repair; GO:0001101 response to acid chemical; GO:0001558 regulation of cell growth; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0003008 system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006469 negative regulation of protein kinase activity; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007049 cell cycle; GO:0007346 regulation of mitotic cell cycle; GO:0007584 response to nutrient; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010466 negative regulation of peptidase activity; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010951 negative regulation of endopeptidase activity; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0018130 heterocycle biosynthetic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030162 regulation of proteolysis; GO:0030308 negative regulation of cell growth; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032526 response to retinoic acid; GO:0033273 response to vitamin; GO:0033280 response to vitamin D; GO:0033554 cellular response to stress; GO:0033673 negative regulation of kinase activity; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0040008 regulation of growth; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043170 macromolecule metabolic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045786 negative regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045861 negative regulation of proteolysis; GO:0045926 negative regulation of growth; GO:0045936 negative regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048102 autophagic cell death; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050954 sensory perception of mechanical stimulus; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051348 negative regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071897 DNA biosynthetic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904030 negative regulation of cyclin-dependent protein kinase activity; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2001020 regulation of response to DNA damage stimulus; GO:2001021 negative regulation of response to DNA damage stimulus; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0000307 cyclin-dependent protein kinase holoenzyme complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0097129 cyclin D2-CDK4 complex; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0004857 enzyme inhibitor activity; GO:0004860 protein kinase inhibitor activity; GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity; GO:0019207 kinase regulator activity; GO:0019210 kinase inhibitor activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0030291 protein serine/threonine kinase inhibitor activity; GO:0098772 molecular function regulator;",null,null,"R","KOG0504","FOG: Ankyrin repeat","WP179 CELL CYCLE;WP45 G1 TO S CELL CYCLE CONTROL;WP2877 VITAMIN D RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP45_r106424;http://www.wikipathways.org/instance/WP2877_r119905",null,"R-HSA-1640170 Cell Cycle;R-HSA-2262752 Cellular responses to stress;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP);R-HSA-2559583 Cellular Senescence;R-HSA-2559585 Oncogene Induced Senescence;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-69231 Cyclin D associated events in G1;R-HSA-69236 G1 Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2559580;https://reactome.org/PathwayBrowser/#/R-HSA-2559582;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-2559585;https://reactome.org/PathwayBrowser/#/R-HSA-453279;https://reactome.org/PathwayBrowser/#/R-HSA-69231;https://reactome.org/PathwayBrowser/#/R-HSA-69236;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-8953897","REACTIVE OXYGEN SPECIES PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"]
["P56524","Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3","HDAC4",0.795553696,0.198551985,"nochange",3190.42,3048.39,2629.68,2748.82,1712.23,2594.31,1.202128882,1.14861293,0.990845807,1.035736961,0.645156793,0.977518628,"nucleus","K11406","HDAC4_5; histone deacetylase 4/5 [EC:3.5.1.98]","hsa04613 Neutrophil extracellular trap formation; hsa05206 MicroRNAs in cancer; hsa05203 Viral carcinogenesis; hsa05034 Alcoholism; hsa04371 Apelin signaling pathway","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001501 skeletal system development; GO:0001503 ossification; GO:0001649 osteoblast differentiation; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0002076 osteoblast development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0003008 system process; GO:0003012 muscle system process; GO:0003299 muscle hypertrophy in response to stress; GO:0003300 cardiac muscle hypertrophy; GO:0006109 regulation of carbohydrate metabolic process; GO:0006110 regulation of glycolytic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006476 protein deacetylation; GO:0006807 nitrogen compound metabolic process; GO:0006937 regulation of muscle contraction; GO:0006942 regulation of striated muscle contraction; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007507 heart development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008016 regulation of heart contraction; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010591 regulation of lamellipodium assembly; GO:0010592 positive regulation of lamellipodium assembly; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010596 negative regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010633 negative regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010677 negative regulation of cellular carbohydrate metabolic process; GO:0010830 regulation of myotube differentiation; GO:0010832 negative regulation of myotube differentiation; GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014854 response to inactivity; GO:0014870 response to muscle inactivity; GO:0014874 response to stimulus involved in regulation of muscle adaptation; GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation; GO:0014887 cardiac muscle adaptation; GO:0014888 striated muscle adaptation; GO:0014894 response to denervation involved in regulation of muscle adaptation; GO:0014896 muscle hypertrophy; GO:0014897 striated muscle hypertrophy; GO:0014898 cardiac muscle hypertrophy in response to stress; GO:0014910 regulation of smooth muscle cell migration; GO:0014911 positive regulation of smooth muscle cell migration; GO:0016043 cellular component organization; GO:0016202 regulation of striated muscle tissue development; GO:0016525 negative regulation of angiogenesis; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0016575 histone deacetylation; GO:0016925 protein sumoylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019722 calcium-mediated signaling; GO:0019932 second-messenger-mediated signaling; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030183 B cell differentiation; GO:0030278 regulation of ossification; GO:0030279 negative regulation of ossification; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030809 negative regulation of nucleotide biosynthetic process; GO:0030811 regulation of nucleotide catabolic process; GO:0030812 negative regulation of nucleotide catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032663 regulation of interleukin-2 production; GO:0032703 negative regulation of interleukin-2 production; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0033233 regulation of protein sumoylation; GO:0033235 positive regulation of protein sumoylation; GO:0033554 cellular response to stress; GO:0034097 response to cytokine; GO:0034612 response to tumor necrosis factor; GO:0034983 peptidyl-lysine deacetylation; GO:0035556 intracellular signal transduction; GO:0035601 protein deacylation; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0042113 B cell activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042594 response to starvation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043434 response to peptide hormone; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043470 regulation of carbohydrate catabolic process; GO:0043500 muscle adaptation; GO:0043502 regulation of muscle adaptation; GO:0043523 regulation of neuron apoptotic process; GO:0043525 positive regulation of neuron apoptotic process; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0043536 positive regulation of blood vessel endothelial cell migration; GO:0043537 negative regulation of blood vessel endothelial cell migration; GO:0043543 protein acylation; GO:0044057 regulation of system process; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045667 regulation of osteoblast differentiation; GO:0045668 negative regulation of osteoblast differentiation; GO:0045765 regulation of angiogenesis; GO:0045766 positive regulation of angiogenesis; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045820 negative regulation of glycolytic process; GO:0045843 negative regulation of striated muscle tissue development; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045912 negative regulation of carbohydrate metabolic process; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045980 negative regulation of nucleotide metabolic process; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0046649 lymphocyte activation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048634 regulation of muscle organ development; GO:0048635 negative regulation of muscle organ development; GO:0048641 regulation of skeletal muscle tissue development; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0048731 system development; GO:0048742 regulation of skeletal muscle fiber development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051154 negative regulation of striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0055117 regulation of cardiac muscle contraction; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060491 regulation of cell projection assembly; GO:0062012 regulation of small molecule metabolic process; GO:0062014 negative regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070555 response to interleukin-1; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0070932 histone H3 deacetylation; GO:0070933 histone H4 deacetylation; GO:0071107 response to parathyroid hormone; GO:0071214 cellular response to abiotic stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071356 cellular response to tumor necrosis factor; GO:0071374 cellular response to parathyroid hormone stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090049 regulation of cell migration involved in sprouting angiogenesis; GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis; GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis; GO:0090257 regulation of muscle system process; GO:0098732 macromolecule deacylation; GO:0104004 cellular response to environmental stimulus; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900372 negative regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1900543 negative regulation of purine nucleotide metabolic process; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901223 negative regulation of NIK/NF-kappaB signaling; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901861 regulation of muscle tissue development; GO:1901862 negative regulation of muscle tissue development; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902743 regulation of lamellipodium organization; GO:1902745 positive regulation of lamellipodium organization; GO:1902893 regulation of miRNA transcription; GO:1902894 negative regulation of miRNA transcription; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903426 regulation of reactive oxygen species biosynthetic process; GO:1903428 positive regulation of reactive oxygen species biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903522 regulation of blood circulation; GO:1903578 regulation of ATP metabolic process; GO:1903579 negative regulation of ATP metabolic process; GO:1903670 regulation of sprouting angiogenesis; GO:1903671 negative regulation of sprouting angiogenesis; GO:1903672 positive regulation of sprouting angiogenesis; GO:1904018 positive regulation of vasculature development; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001169 regulation of ATP biosynthetic process; GO:2001170 negative regulation of ATP biosynthetic process;","GO:0000118 histone deacetylase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0017053 transcription repressor complex; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0031594 neuromuscular junction; GO:0031672 A band; GO:0031674 I band; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0042641 actomyosin; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0004407 histone deacetylase activity; GO:0005080 protein kinase C binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016811 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in linear amides; GO:0019213 deacetylase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019789 SUMO transferase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030955 potassium ion binding; GO:0031420 alkali metal ion binding; GO:0033558 protein deacetylase activity; GO:0042802 identical protein binding; GO:0042826 histone deacetylase binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0071889 14-3-3 protein binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding; GO:1990841 promoter-specific chromatin binding;","PF00850","PF00850 Histone deacetylase domain","B","KOG1343","Histone deacetylase complex"," catalytic component HDA1","WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE;WP4874 CAMKK2 PATHWAY;WP2795 CARDIAC HYPERTROPHIC RESPONSE;WP474 ENDOCHONDRAL OSSIFICATION;WP4808 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS;WP3996 ETHANOL EFFECTS ON HISTONE MODIFICATIONS;WP1992 GENES TARGETED BY MIRNAS IN ADIPOCYTES;WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP2064 NEURAL CREST DIFFERENTIATION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3878_r117656;http://www.wikipathways.org/instance/WP4874_r117669;http://www.wikipathways.org/instance/WP2795_r117670;http://www.wikipathways.org/instance/WP474_r117098;http://www.wikipathways.org/instance/WP4808_r117708;http://www.wikipathways.org/instance/WP3996_r107156;http://www.wikipathways.org/instance/WP1992_r105839;http://www.wikipathways.org/instance/WP3414_r106735;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP2064_r117162;http://www.wikipathways.org/instance/WP3888_r116782","Transcription factor","R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-1980143 Signaling by NOTCH1;R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription;R-HSA-212436 Generic Transcription Pathway;R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer;R-HSA-2644603 Signaling by NOTCH1 in Cancer;R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants;R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer;R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-350054 Notch-HLH transcription pathway;R-HSA-392499 Metabolism of proteins;R-HSA-4090294 SUMOylation of intracellular receptors;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-597592 Post-translational protein modification;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8941284 RUNX2 regulates chondrocyte maturation;R-HSA-8941326 RUNX2 regulates bone development;R-HSA-8951936 RUNX3 regulates p14-ARF","https://reactome.org/PathwayBrowser/#/R-HSA-157118;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1980143;https://reactome.org/PathwayBrowser/#/R-HSA-2122947;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2644602;https://reactome.org/PathwayBrowser/#/R-HSA-2644603;https://reactome.org/PathwayBrowser/#/R-HSA-2644606;https://reactome.org/PathwayBrowser/#/R-HSA-2894858;https://reactome.org/PathwayBrowser/#/R-HSA-2894862;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-350054;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4090294;https://reactome.org/PathwayBrowser/#/R-HSA-4551638;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878159;https://reactome.org/PathwayBrowser/#/R-HSA-8878166;https://reactome.org/PathwayBrowser/#/R-HSA-8941284;https://reactome.org/PathwayBrowser/#/R-HSA-8941326;https://reactome.org/PathwayBrowser/#/R-HSA-8951936"]
["P56962","Syntaxin-17 OS=Homo sapiens OX=9606 GN=STX17 PE=1 SV=2","STX17",0.786899182,0.002605818,"down",36125.9,39355.8,36854.8,28082.4,30536.3,29778.8,1.079814082,1.176356771,1.101601124,0.839391433,0.912739247,0.890097343,"cytoplasm","K08491","STX17; syntaxin 17","hsa04140 Autophagy - animal; hsa04130 SNARE interactions in vesicular transport","GO:0000045 autophagosome assembly; GO:0001505 regulation of neurotransmitter levels; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006904 vesicle docking involved in exocytosis; GO:0006906 vesicle fusion; GO:0006914 autophagy; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007033 vacuole organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010256 endomembrane system organization; GO:0010506 regulation of autophagy; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016081 synaptic vesicle docking; GO:0016192 vesicle-mediated transport; GO:0016236 macroautophagy; GO:0016240 autophagosome membrane docking; GO:0017156 calcium-ion regulated exocytosis; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0022406 membrane docking; GO:0022411 cellular component disassembly; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0023061 signal release; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032940 secretion by cell; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034497 protein localization to phagophore assembly site; GO:0034613 cellular protein localization; GO:0042592 homeostatic process; GO:0042594 response to starvation; GO:0042886 amide transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0045055 regulated exocytosis; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048278 vesicle docking; GO:0048284 organelle fusion; GO:0048489 synaptic vesicle transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0060249 anatomical structure homeostasis; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070050 neuron cellular homeostasis; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071496 cellular response to external stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090174 organelle membrane fusion; GO:0097111 endoplasmic reticulum-Golgi intermediate compartment organization; GO:0097352 autophagosome maturation; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering; GO:1905037 autophagosome organization;","GO:0000421 autophagosome membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005776 autophagosome; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005790 smooth endoplasmic reticulum; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005798 Golgi-associated vesicle; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030134 COPII-coated ER to Golgi transport vesicle; GO:0030135 coated vesicle; GO:0030868 smooth endoplasmic reticulum membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044232 organelle membrane contact site; GO:0044233 mitochondria-associated endoplasmic reticulum membrane; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000149 SNARE binding; GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0044877 protein-containing complex binding;",null,null,"U","KOG0811","SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["P58546","Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2","MTPN",1.365794624,0.000873062,"up",32760.8,29765.7,29854.3,43318.1,41705.8,41149.3,0.899387794,0.817162806,0.819595157,1.18921914,1.144956395,1.129678706,"cytoplasm",{"$nulls":3},"GO:0001558 regulation of cell growth; GO:0006355 regulation of transcription"," DNA-templated; GO:0006417 regulation of translation; GO:0006584 catecholamine metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008152 metabolic process; GO:0008361 regulation of cell size; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009712 catechol-containing compound metabolic process; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010611 regulation of cardiac muscle hypertrophy; GO:0010613 positive regulation of cardiac muscle hypertrophy; GO:0014742 positive regulation of muscle hypertrophy; GO:0014743 regulation of muscle hypertrophy; GO:0016043 cellular component organization; GO:0016202 regulation of striated muscle tissue development; GO:0018958 phenol-containing compound metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0021533 cell differentiation in hindbrain; GO:0021549 cerebellum development; GO:0021575 hindbrain morphogenesis; GO:0021587 cerebellum morphogenesis; GO:0021681 cerebellar granular layer development; GO:0021683 cerebellar granular layer morphogenesis; GO:0021684 cerebellar granular layer formation; GO:0021695 cerebellar cortex development; GO:0021696 cerebellar cortex morphogenesis; GO:0021697 cerebellar cortex formation; GO:0021707 cerebellar granule cell differentiation; GO:0021953 central nervous system neuron differentiation; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030834 regulation of actin filament depolymerization; GO:0030902 hindbrain development; GO:0031099 regeneration; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0034248 regulation of cellular amide metabolic process; GO:0040007 growth; GO:0040008 regulation of growth; GO:0042060 wound healing; GO:0042246 tissue regeneration; GO:0042692 muscle cell differentiation; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043403 skeletal muscle tissue regeneration; GO:0043502 regulation of muscle adaptation; GO:0044057 regulation of system process; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0045927 positive regulation of growth; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048589 developmental growth; GO:0048634 regulation of muscle organ development; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051128 regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051493 regulation of cytoskeleton organization; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071214 cellular response to abiotic stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090257 regulation of muscle system process; GO:0104004 cellular response to environmental stimulus; GO:0110053 regulation of actin filament organization; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901861 regulation of muscle tissue development; GO:1901879 regulation of protein depolymerization; GO:1902903 regulation of supramolecular fiber organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000812 regulation of barbed-end actin filament capping; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0008290 F-actin capping protein complex; GO:0015629 actin cytoskeleton; GO:0030424 axon; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0120025 plasma membrane bounded cell projection;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG4214","Myotrophin and similar proteins"]
["P60174","Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4","TPI1",1.21548931,{"v":6.6455E-5,"d":"6.65E-05"},"up",532781,531387,547847,655693,645761,657933,0.895078739,0.892736802,0.920389808,1.101572436,1.084886552,1.105335664,"cytoplasm","K01803","TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]","hsa00010 Glycolysis / Gluconeogenesis; hsa00051 Fructose and mannose metabolism; hsa01200 Carbon metabolism; hsa00562 Inositol phosphate metabolism; hsa01230 Biosynthesis of amino acids; hsa01100 Metabolic pathways","GO:0000768 syncytium formation by plasma membrane fusion; GO:0003008 system process; GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006006 glucose metabolic process; GO:0006007 glucose catabolic process; GO:0006066 alcohol metabolic process; GO:0006071 glycerol metabolic process; GO:0006081 cellular aldehyde metabolic process; GO:0006082 organic acid metabolic process; GO:0006090 pyruvate metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006094 gluconeogenesis; GO:0006096 glycolytic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006165 nucleoside diphosphate phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006734 NADH metabolic process; GO:0006735 NADH regeneration; GO:0006753 nucleoside phosphate metabolic process; GO:0006754 ATP biosynthetic process; GO:0006757 ATP generation from ADP; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006949 syncytium formation; GO:0007275 multicellular organism development; GO:0007520 myoblast fusion; GO:0007525 somatic muscle development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009132 nucleoside diphosphate metabolic process; GO:0009135 purine nucleoside diphosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009142 nucleoside triphosphate biosynthetic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009145 purine nucleoside triphosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009166 nucleotide catabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009179 purine ribonucleoside diphosphate metabolic process; GO:0009185 ribonucleoside diphosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009201 ribonucleoside triphosphate biosynthetic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009206 purine ribonucleoside triphosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009435 NAD biosynthetic process; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0014902 myotube differentiation; GO:0016051 carbohydrate biosynthetic process; GO:0016052 carbohydrate catabolic process; GO:0016053 organic acid biosynthetic process; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019318 hexose metabolic process; GO:0019319 hexose biosynthetic process; GO:0019320 hexose catabolic process; GO:0019359 nicotinamide nucleotide biosynthetic process; GO:0019362 pyridine nucleotide metabolic process; GO:0019363 pyridine nucleotide biosynthetic process; GO:0019400 alditol metabolic process; GO:0019405 alditol catabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019563 glycerol catabolic process; GO:0019637 organophosphate metabolic process; GO:0019674 NAD metabolic process; GO:0019682 glyceraldehyde-3-phosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019725 cellular homeostasis; GO:0019751 polyol metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0033500 carbohydrate homeostasis; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042692 muscle cell differentiation; GO:0042866 pyruvate biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044275 cellular carbohydrate catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0045454 cell redox homeostasis; GO:0046031 ADP metabolic process; GO:0046034 ATP metabolic process; GO:0046164 alcohol catabolic process; GO:0046166 glyceraldehyde-3-phosphate biosynthetic process; GO:0046174 polyol catabolic process; GO:0046184 aldehyde biosynthetic process; GO:0046364 monosaccharide biosynthetic process; GO:0046365 monosaccharide catabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0046700 heterocycle catabolic process; GO:0046939 nucleotide phosphorylation; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0051146 striated muscle cell differentiation; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061061 muscle structure development; GO:0061615 glycolytic process through fructose-6-phosphate; GO:0061620 glycolytic process through glucose-6-phosphate; GO:0061621 canonical glycolysis; GO:0061718 glucose catabolic process to pyruvate; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072524 pyridine-containing compound metabolic process; GO:0072525 pyridine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901616 organic hydroxy compound catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0031430 M band; GO:0031672 A band; GO:0031674 I band; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0003824 catalytic activity; GO:0004807 triose-phosphate isomerase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016853 isomerase activity; GO:0016860 intramolecular oxidoreductase activity; GO:0016861 intramolecular oxidoreductase activity"," interconverting aldoses and ketoses; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0044389 ubiquitin-like protein ligase binding; GO:0046983 protein dimerization activity;","PF00121","PF00121 Triosephosphate isomerase","G","KOG1643","Triosephosphate isomerase","WP4629 AEROBIC GLYCOLYSIS;WP4018 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS;WP1946 CORI CYCLE;WP143 FATTY ACID BETAOXIDATION;WP534 GLYCOLYSIS AND GLUCONEOGENESIS;WP2456 HIF1A AND PPARG REGULATION OF GLYCOLYSIS","http://www.wikipathways.org/instance/WP4629_r119264;http://www.wikipathways.org/instance/WP4018_r117168;http://www.wikipathways.org/instance/WP1946_r119982;http://www.wikipathways.org/instance/WP143_r116506;http://www.wikipathways.org/instance/WP534_r117147;http://www.wikipathways.org/instance/WP2456_r119185",null,"R-HSA-1430728 Metabolism;R-HSA-70171 Glycolysis;R-HSA-70263 Gluconeogenesis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70171;https://reactome.org/PathwayBrowser/#/R-HSA-70263;https://reactome.org/PathwayBrowser/#/R-HSA-70326;https://reactome.org/PathwayBrowser/#/R-HSA-71387","GLYCOLYSIS;HYPOXIA;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["P60981","Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3","DSTN",1.263822696,0.001435091,"up",39715.1,42130.3,39433.4,49536.8,50529.9,53208.2,0.867919828,0.920700759,0.861763655,1.082559805,1.104262663,1.16279329,"mitochondria","K10363",null,null,"GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000281 mitotic cytokinesis; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0000910 cytokinesis; GO:0000912 assembly of actomyosin apparatus involved in cytokinesis; GO:0000915 actomyosin contractile ring assembly; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001736 establishment of planar polarity; GO:0001737 establishment of imaginal disc-derived wing hair orientation; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001894 tissue homeostasis; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002165 instar larval or pupal development; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007098 centrosome cycle; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008154 actin polymerization or depolymerization; GO:0008406 gonad development; GO:0008544 epidermis development; GO:0008585 female gonad development; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009913 epidermal cell differentiation; GO:0009987 cellular process; GO:0010591 regulation of lamellipodium assembly; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010669 epithelial structure maintenance; GO:0010927 cellular component assembly involved in morphogenesis; GO:0014866 skeletal myofibril assembly; GO:0016043 cellular component organization; GO:0016319 mushroom body development; GO:0016477 cell migration; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030032 lamellipodium assembly; GO:0030036 actin cytoskeleton organization; GO:0030041 actin filament polymerization; GO:0030042 actin filament depolymerization; GO:0030043 actin filament fragmentation; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030239 myofibril assembly; GO:0030240 skeletal muscle thin filament assembly; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030834 regulation of actin filament depolymerization; GO:0030836 positive regulation of actin filament depolymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031023 microtubule organizing center organization; GO:0031032 actomyosin structure organization; GO:0031175 neuron projection development; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032506 cytokinetic process; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032984 protein-containing complex disassembly; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033206 meiotic cytokinesis; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035285 appendage segmentation; GO:0035295 tube development; GO:0035315 hair cell differentiation; GO:0035316 non-sensory hair organization; GO:0035317 imaginal disc-derived wing hair organization; GO:0036011 imaginal disc-derived leg segmentation; GO:0040011 locomotion; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042067 establishment of ommatidial planar polarity; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0042592 homeostatic process; GO:0042692 muscle cell differentiation; GO:0043243 positive regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0044837 actomyosin contractile ring organization; GO:0045137 development of primary sexual characteristics; GO:0046530 photoreceptor cell differentiation; GO:0046545 development of primary female sexual characteristics; GO:0046660 female sex differentiation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048592 eye morphogenesis; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048871 multicellular organismal homeostasis; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051014 actin filament severing; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051258 protein polymerization; GO:0051261 protein depolymerization; GO:0051299 centrosome separation; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0060249 anatomical structure homeostasis; GO:0060322 head development; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070925 organelle assembly; GO:0071689 muscle thin filament assembly; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090596 sensory organ morphogenesis; GO:0097435 supramolecular fiber organization; GO:0097581 lamellipodium organization; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901879 regulation of protein depolymerization; GO:1901881 positive regulation of protein depolymerization; GO:1902743 regulation of lamellipodium organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904951 positive regulation of establishment of protein localization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005865 striated muscle thin filament; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0036379 myofilament; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099568 cytoplasmic region;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;","PF00241","PF00241 Cofilin/tropomyosin-type actin-binding protein","Z","KOG1735","Actin depolymerizing factor","WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP138_r120688"]
["P61088","Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1","UBE2N",1.09140171,0.014161943,"nochange",227573,221040,215740,247980,241057,236039,0.982733195,0.954521606,0.931634506,1.070857165,1.040961431,1.019292098,"mitochondria","K10580","UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]","hsa04120 Ubiquitin mediated proteolysis; hsa05131 Shigellosis","GO:0000165 MAPK cascade; GO:0000209 protein polyubiquitination; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0000729 DNA double-strand break processing; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002218 activation of innate immune response; GO:0002221 pattern recognition receptor signaling pathway; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002753 cytoplasmic pattern recognition receptor signaling pathway; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006282 regulation of DNA repair; GO:0006301 postreplication repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006310 DNA recombination; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006974 cellular response to DNA damage stimulus; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007412 axon target recognition; GO:0007416 synapse assembly; GO:0007528 neuromuscular junction development; GO:0007610 behavior; GO:0007625 grooming behavior; GO:0007626 locomotory behavior; GO:0007629 flight behavior; GO:0007630 jump response; GO:0008152 metabolic process; GO:0008344 adult locomotory behavior; GO:0008594 photoreceptor cell morphogenesis; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009653 anatomical structure morphogenesis; GO:0009794 regulation of mitotic cell cycle"," embryonic; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016567 protein ubiquitination; GO:0016570 histone modification; GO:0016574 histone ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030522 intracellular receptor signaling pathway; GO:0030534 adult behavior; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033182 regulation of histone ubiquitination; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0035556 intracellular signal transduction; GO:0035872 nucleotide-binding domain"," leucine rich repeat containing receptor signaling pathway; GO:0036211 protein modification process; GO:0040007 growth; GO:0040019 positive regulation of embryonic development; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042461 photoreceptor cell development; GO:0042742 defense response to bacterium; GO:0043085 positive regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045739 positive regulation of DNA repair; GO:0045787 positive regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045931 positive regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045977 positive regulation of mitotic cell cycle"," embryonic; GO:0045995 regulation of embryonic development; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046483 heterocycle metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048589 developmental growth; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051094 positive regulation of developmental process; GO:0051124 synaptic assembly at neuromuscular junction; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051438 regulation of ubiquitin-protein transferase activity; GO:0051443 positive regulation of ubiquitin-protein transferase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060074 synapse maturation; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061057 peptidoglycan recognition protein signaling pathway; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070534 protein K63-linked ubiquitination; GO:0070555 response to interleukin-1; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072347 response to anesthetic; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0098542 defense response to other organism; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902914 regulation of protein polyubiquitination; GO:1902916 positive regulation of protein polyubiquitination; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1905269 positive regulation of chromatin organization; GO:2000008 regulation of protein localization to cell surface; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001020 regulation of response to DNA damage stimulus; GO:2001022 positive regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000151 ubiquitin ligase complex; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031371 ubiquitin conjugating enzyme complex; GO:0031372 UBC13-MMS2 complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035370 UBC13-UEV1A complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0031624 ubiquitin conjugating enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0032182 ubiquitin-like protein binding; GO:0043130 ubiquitin binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044390 ubiquitin-like protein conjugating enzyme binding; GO:0061630 ubiquitin protein ligase activity; GO:0061631 ubiquitin conjugating enzyme activity; GO:0061650 ubiquitin-like protein conjugating enzyme activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00179","PF00179 Ubiquitin-conjugating enzyme","O","KOG0417","Ubiquitin-protein ligase","WP4906 3Q29 COPY NUMBER VARIATION SYNDROME;WP195 IL1 SIGNALING PATHWAY;WP3656 INTERLEUKIN1 INDUCED ACTIVATION OF NFKB;WP3877 MYD88 DISTINCT INPUTOUTPUT PATHWAY","http://www.wikipathways.org/instance/WP4906_r115773;http://www.wikipathways.org/instance/WP195_r120702;http://www.wikipathways.org/instance/WP3656_r117955;http://www.wikipathways.org/instance/WP3877_r117828",null,"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1632852 Macroautophagy;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168638 NOD1/2 Signaling Pathway;R-HSA-168643 Nucleotide-binding domain"," leucine rich repeat containing receptor (NLR) signaling pathways;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-168927 TICAM1"," RIP1-mediated IKK complex recruitment;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-392499 Metabolism of proteins;R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation  ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-448424 Interleukin-17 signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450294 MAP kinase activation;R-HSA-450302 activated TAK1 mediates p38 MAPK activation;R-HSA-450321 JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5663205 Infectious disease;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693571 Nonhomologous End-Joining (NHEJ);R-HSA-5693606 DNA Double Strand Break Response;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5696395 Formation of Incision Complex in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-597592 Post-translational protein modification;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73894 DNA Repair;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins;R-HSA-9020702 Interleukin-1 signaling;R-HSA-913531 Interferon Signaling;R-HSA-937039 IRAK1 recruits IKK complex;R-HSA-937041 IKK complex recruitment mediated by RIP1;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-9612973 Autophagy;R-HSA-9646399 Aggrephagy;R-HSA-9663891 Selective autophagy;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-975871 MyD88 cascade initiated on plasma membrane;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation",null,"ALLOGRAFT REJECTION;PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["P61289","Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1","PSME3",0.740970602,3.38835E-4,"down",107055,100711,107626,76836.3,80313.6,76546.3,1.169812063,1.100489867,1.176051498,0.839606096,0.87760327,0.836437206,"cytoplasm","K06698","PSME3; proteasome activator subunit 3 (PA28 gamma)","hsa05160 Hepatitis C; hsa04612 Antigen processing and presentation; hsa03050 Proteasome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010466 negative regulation of peptidase activity; GO:0010467 gene expression; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010951 negative regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016579 protein deubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043687 post-translational protein modification; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001237 negative regulation of extrinsic apoptotic signaling pathway;","GO:0000502 proteasome complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005703 polytene chromosome puff; GO:0005705 polytene chromosome interband; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;","GO:0002039 p53 binding; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0016504 peptidase activator activity; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0042802 identical protein binding; GO:0061133 endopeptidase activator activity; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0097371 MDM2/MDM4 family protein binding; GO:0098772 molecular function regulator;",null,null,"O","KOG4470","Proteasome activator subunit","WP183 PROTEASOME DEGRADATION","http://www.wikipathways.org/instance/WP183_r117060",null,"R-HSA-109581 Apoptosis;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1169091 Activation of NF-kappaB in B cells;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes);R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-169911 Regulation of Apoptosis;R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C;R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1;R-HSA-174143 APC/C-mediated degradation of cell cycle proteins;R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin;R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1;R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A;R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase;R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins;R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint;R-HSA-180534 Vpu mediated degradation of CD4;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2871837 FCERI mediated NF-kB activation;R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1;R-HSA-350562 Regulation of ornithine decarboxylase (ODC);R-HSA-351202 Metabolism of polyamines;R-HSA-376176 Signaling by ROBO receptors;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-392499 Metabolism of proteins;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA;R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453276 Regulation of mitotic cell cycle;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-4608870 Asymmetric localization of PCP proteins;R-HSA-4641257 Degradation of AXIN;R-HSA-4641258 Degradation of DVL;R-HSA-5357801 Programmed Cell Death;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5668541 TNFR2 non-canonical NF-kB pathway;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5676590 NIK-->noncanonical NF-kB signaling;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5687128 MAPK6/MAPK4 signaling;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-6807070 PTEN Regulation;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69206 G1/S Transition;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69481 G2/M Checkpoints;R-HSA-69541 Stabilization of p53;R-HSA-69563 p53-Dependent G1 DNA Damage Response;R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint;R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;R-HSA-69610 p53-Independent DNA Damage Response;R-HSA-69613 p53-Independent G1/S DNA damage checkpoint;R-HSA-69615 G1/S DNA Damage Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D;R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint;R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878159 Transcriptional regulation by RUNX3;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8941858 Regulation of RUNX3 expression and activity;R-HSA-8948751 Regulation of PTEN stability and activity;R-HSA-8951664 Neddylation;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["P61803","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 OS=Homo sapiens OX=9606 GN=DAD1 PE=1 SV=3","DAD1",1.047001509,0.260891376,"nochange",184829,203454,189741,207583,203938,193671,0.93725406,1.031700045,0.962162445,1.052637895,1.034154372,0.982091182,"plasma membrane","K12668","OST2; oligosaccharyltransferase complex subunit epsilon","hsa00510 N-Glycan biosynthesis; hsa00513 Various types of N-glycan biosynthesis; hsa04141 Protein processing in endoplasmic reticulum; hsa01100 Metabolic pathways","GO:0001701 in utero embryonic development; GO:0001824 blastocyst development; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006487 protein N-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007584 response to nutrient; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009605 response to external stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010941 regulation of cell death; GO:0018193 peptidyl-amino acid modification; GO:0018196 peptidyl-asparagine modification; GO:0018279 protein N-linked glycosylation via asparagine; GO:0019538 protein metabolic process; GO:0031667 response to nutrient levels; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0008250 oligosaccharyltransferase complex; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1990234 transferase complex;",{"$nulls":3},"DO","KOG1746","Defender against cell death protein/oligosaccharyltransferase"," epsilon subunit",{"$nulls":3},"R-HSA-1643685 Disease;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694548 Maturation of spike protein;R-HSA-9694635 Translation of Structural Proteins;R-HSA-9772573 Late SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694548;https://reactome.org/PathwayBrowser/#/R-HSA-9694635;https://reactome.org/PathwayBrowser/#/R-HSA-9772573","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["P61970","Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1","NUTF2",0.934510417,0.465460834,"nochange",43170.5,50345.6,53559.2,43824.7,42975.7,50643,0.910390073,1.061700338,1.129469522,0.924186003,0.906282083,1.067971982,"cytoplasm","nucleus",{"$nulls":3},"GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0002225 positive regulation of antimicrobial peptide production; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002702 positive regulation of production of molecular mediator of immune response; GO:0002759 regulation of antimicrobial humoral response; GO:0002760 positive regulation of antimicrobial humoral response; GO:0002784 regulation of antimicrobial peptide production; GO:0002805 regulation of antimicrobial peptide biosynthetic process; GO:0002807 positive regulation of antimicrobial peptide biosynthetic process; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0002920 regulation of humoral immune response; GO:0002922 positive regulation of humoral immune response; GO:0006606 protein import into nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010574 regulation of vascular endothelial growth factor production; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0017038 protein import; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033365 protein localization to organelle; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0090087 regulation of peptide transport; GO:0090204 protein localization to nuclear pore; GO:0090316 positive regulation of intracellular protein transport; GO:0090435 protein localization to nuclear envelope; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1903829 positive regulation of protein localization; GO:1904046 negative regulation of vascular endothelial growth factor production; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904951 positive regulation of establishment of protein localization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005640 nuclear outer membrane; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044613 nuclear pore central transport channel; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;","GO:0005198 structural molecule activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0017056 structural constituent of nuclear pore; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0051020 GTPase binding; GO:0061608 nuclear import signal receptor activity; GO:0140104 molecular carrier activity; GO:0140142 nucleocytoplasmic carrier activity;","PF02136","PF02136 Nuclear transport factor 2 (NTF2) domain","U","KOG2104","Nuclear transport factor 2"]
["P62244","40S ribosomal protein S15a OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2","RPS15A",1.023639903,0.347611265,"nochange",248093,261120,247939,263659,259833,251559,0.971514871,1.022527694,0.970911818,1.032470241,1.017487892,0.985087485,"cytoplasm","K02957","RP-S15Ae; small subunit ribosomal protein S15Ae","hsa03010 Ribosome; hsa05171 Coronavirus disease - COVID-19","GO:0000184 nuclear-transcribed mRNA catabolic process"," nonsense-mediated decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006412 translation; GO:0006413 translational initiation; GO:0006518 peptide metabolic process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006613 cotranslational protein targeting to membrane; GO:0006614 SRP-dependent cotranslational protein targeting to membrane; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019538 protein metabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042127 regulation of cell population proliferation; GO:0042886 amide transport; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045047 protein targeting to ER; GO:0045184 establishment of protein localization; GO:0045787 positive regulation of cell cycle; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051707 response to other organism; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070972 protein localization to endoplasmic reticulum; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072594 establishment of protein localization to organelle; GO:0072599 establishment of protein localization to endoplasmic reticulum; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005840 ribosome; GO:0015935 small ribosomal subunit; GO:0022626 cytosolic ribosome; GO:0022627 cytosolic small ribosomal subunit; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;","PF00410","PF00410 Ribosomal protein S8","J","KOG1754","40S ribosomal protein S15/S22","WP477 CYTOPLASMIC RIBOSOMAL PROTEINS","http://www.wikipathways.org/instance/WP477_r117044",null,"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-156842 Eukaryotic Translation Elongation;R-HSA-156902 Peptide chain elongation;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-192823 Viral mRNA Translation;R-HSA-2262752 Cellular responses to stress;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-2408557 Selenocysteine synthesis;R-HSA-376176 Signaling by ROBO receptors;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-5663205 Infectious disease;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-72312 rRNA processing;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72649 Translation initiation complex formation;R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72695 Formation of the ternary complex"," and subsequently"," the 43S complex;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72764 Eukaryotic Translation Termination;R-HSA-72766 Translation;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-927802 Nonsense-Mediated Decay (NMD);R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency;R-HSA-9675108 Nervous system development;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-9711097 Cellular response to starvation;R-HSA-9754678 SARS-CoV-2 modulates host translation machinery;R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["P62306","Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1","SNRPF",1.056232856,0.570586616,"nochange",47702.4,34994.5,34508.6,41851.9,42004.3,39940.1,1.187602748,0.871225858,0.859128853,1.041948234,1.045742397,0.994351909,"cytoplasm","K11098","SNRPF; small nuclear ribonucleoprotein F","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006353 DNA-templated transcription"," termination; GO:0006366 transcription by RNA polymerase II; GO:0006369 termination of RNA polymerase II transcription; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006913 nucleocytoplasmic transport; GO:0008152 metabolic process; GO:0008334 histone mRNA metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005683 U7 snRNP; GO:0005684 U2-type spliceosomal complex; GO:0005685 U1 snRNP; GO:0005687 U4 snRNP; GO:0005689 U12-type spliceosomal complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0034709 methylosome; GO:0034715 pICln-Sm protein complex; GO:0034719 SMN-Sm protein complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071007 U2-type catalytic step 2 spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1902494 catalytic complex; GO:1990234 transferase complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF01423","PF01423 LSM domain ","A","KOG3482","Small nuclear ribonucleoprotein (snRNP) SMF","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs;R-HSA-1643685 Disease;R-HSA-191859 snRNP Assembly;R-HSA-194441 Metabolism of non-coding RNA;R-HSA-5663205 Infectious disease;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72165 mRNA Splicing - Minor Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75067 Processing of Capped Intronless Pre-mRNA;R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs;R-HSA-8953854 Metabolism of RNA;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-9754678 SARS-CoV-2 modulates host translation machinery","https://reactome.org/PathwayBrowser/#/R-HSA-111367;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-191859;https://reactome.org/PathwayBrowser/#/R-HSA-194441;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72165;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75067;https://reactome.org/PathwayBrowser/#/R-HSA-77588;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9705683;https://reactome.org/PathwayBrowser/#/R-HSA-9754678"]
["P62807","Histone H2B type 1-C/E/F/G/I OS=Homo sapiens OX=9606 GN=H2BC10 PE=1 SV=4","H2BC10",1.025111149,0.394927301,"nochange",2946800,3195910,3175860,3177390,3219470,3155710,0.93692273,1.016126212,1.009751398,1.010237855,1.023617015,1.00334479,"nucleus","K11252","H2B; histone H2B","hsa05322 Systemic lupus erythematosus; hsa04613 Neutrophil extracellular trap formation; hsa05203 Viral carcinogenesis; hsa05034 Alcoholism","GO:0002227 innate immune response in mucosa; GO:0002251 organ or tissue specific immune response; GO:0002376 immune system process; GO:0002385 mucosal immune response; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006334 nucleosome assembly; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0019730 antimicrobial humoral response; GO:0019731 antibacterial humoral response; GO:0022607 cellular component assembly; GO:0031497 chromatin assembly; GO:0032446 protein modification by small protein conjugation; GO:0034728 nucleosome organization; GO:0036211 protein modification process; GO:0042742 defense response to bacterium; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0050830 defense response to Gram-positive bacterium; GO:0050896 response to stimulus; GO:0051276 chromosome organization; GO:0051707 response to other organism; GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0070647 protein modification by small protein conjugation or removal; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0098542 defense response to other organism; GO:1901564 organonitrogen compound metabolic process;","GO:0000785 chromatin; GO:0000786 nucleosome; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044815 DNA packaging complex; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00125","PF00125 Core histone H2A/H2B/H3/H4","B","KOG1744","Histone H2B",{"$nulls":3},"R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine;R-HSA-110329 Cleavage of the damaged pyrimidine ;R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine;R-HSA-110331 Cleavage of the damaged purine;R-HSA-1221632 Meiotic synapsis;R-HSA-1266738 Developmental Biology;R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-157118 Signaling by NOTCH;R-HSA-157579 Telomere Maintenance;R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-171306 Packaging Of Telomere Ends;R-HSA-1912408 Pre-NOTCH Transcription and Translation;R-HSA-1912422 Pre-NOTCH Expression and Processing;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex;R-HSA-211000 Gene Silencing by RNA;R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-212300 PRC2 methylates histones and DNA;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2299718 Condensation of Prophase Chromosomes;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP);R-HSA-2559583 Cellular Senescence;R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence;R-HSA-3214815 HDACs deacetylate histones;R-HSA-3214847 HATs acetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-392499 Metabolism of proteins;R-HSA-427359 SIRT1 negatively regulates rRNA expression;R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-4839726 Chromatin organization;R-HSA-5250913 Positive epigenetic regulation of rRNA expression;R-HSA-5250924 B-WICH complex positively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-5334118 DNA methylation;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-5625740 RHO GTPases activate PKNs;R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3;R-HSA-5663205 Infectious disease;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693571 Nonhomologous End-Joining (NHEJ);R-HSA-5693606 DNA Double Strand Break Response;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-597592 Post-translational protein modification;R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere;R-HSA-68616 Assembly of the ORC complex at the origin of replication;R-HSA-68867 Assembly of the pre-replicative complex;R-HSA-68875 Mitotic Prophase;R-HSA-68886 M Phase;R-HSA-69002 DNA Replication Pre-Initiation;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-69473 G2/M DNA damage checkpoint;R-HSA-69481 G2/M Checkpoints;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-73728 RNA Polymerase I Promoter Opening;R-HSA-73772 RNA Polymerase I Promoter Escape;R-HSA-73854 RNA Polymerase I Promoter Clearance;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73864 RNA Polymerase I Transcription;R-HSA-73884 Base Excision Repair;R-HSA-73886 Chromosome Maintenance;R-HSA-73894 DNA Repair;R-HSA-73927 Depurination;R-HSA-73928 Depyrimidination;R-HSA-73929 Base-Excision Repair"," AP Site Formation;R-HSA-74160 Gene expression (Transcription);R-HSA-774815 Nucleosome assembly;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function;R-HSA-8939211 ESR-mediated signaling;R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9018519 Estrogen-dependent gene expression;R-HSA-912446 Meiotic recombination;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9610379 HCMV Late Events;R-HSA-9616222 Transcriptional regulation of granulopoiesis;R-HSA-9645723 Diseases of programmed cell death;R-HSA-9670095 Inhibition of DNA recombination at telomere;R-HSA-9710421 Defective pyroptosis;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-977225 Amyloid fiber formation"]
["P62877","E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1","RBX1",1.104729328,0.151831566,"nochange",17527.1,20269.3,16902.7,20390.4,20555.3,19482,0.913450213,1.05636394,0.880908702,1.062675242,1.071269244,1.015332659,"extracellular","K03868","RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]","hsa05170 Human immunodeficiency virus 1 infection; hsa05211 Renal cell carcinoma; hsa04350 TGF-beta signaling pathway; hsa03420 Nucleotide excision repair; hsa05200 Pathways in cancer; hsa05131 Shigellosis; hsa04066 HIF-1 signaling pathway; hsa04310 Wnt signaling pathway; hsa04710 Circadian rhythm; hsa04110 Cell cycle; hsa04120 Ubiquitin mediated proteolysis; hsa04141 Protein processing in endoplasmic reticulum; hsa04114 Oocyte meiosis","GO:0000165 MAPK cascade; GO:0000209 protein polyubiquitination; GO:0000715 nucleotide-excision repair"," DNA damage recognition; GO:0001666 response to hypoxia; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006293 nucleotide-excision repair"," preincision complex stabilization; GO:0006294 nucleotide-excision repair"," preincision complex assembly; GO:0006296 nucleotide-excision repair"," DNA incision"," 5'-to lesion; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006513 protein monoubiquitination; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010265 SCF complex assembly; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010876 lipid localization; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0014041 regulation of neuron maturation; GO:0014042 positive regulation of neuron maturation; GO:0016043 cellular component organization; GO:0016055 Wnt signaling pathway; GO:0016310 phosphorylation; GO:0016567 protein ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019915 lipid storage; GO:0019941 modification-dependent protein catabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030178 negative regulation of Wnt signaling pathway; GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0033683 nucleotide-excision repair"," DNA incision; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045116 protein neddylation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045732 positive regulation of protein catabolic process; GO:0045786 negative regulation of cell cycle; GO:0045862 positive regulation of proteolysis; GO:0045930 negative regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070482 response to oxygen levels; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070555 response to interleukin-1; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0070911 global genome nucleotide-excision repair; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0198738 cell-cell signaling by wnt; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903429 regulation of cell maturation; GO:1903431 positive regulation of cell maturation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1904799 regulation of neuron remodeling; GO:1904801 positive regulation of neuron remodeling; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:2000026 regulation of multicellular organismal development; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0000152 nuclear ubiquitin ligase complex; GO:0000153 cytoplasmic ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005680 anaphase-promoting complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0019005 SCF ubiquitin ligase complex; GO:0030891 VCB complex; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031462 Cul2-RING ubiquitin ligase complex; GO:0031463 Cul3-RING ubiquitin ligase complex; GO:0031464 Cul4A-RING E3 ubiquitin ligase complex; GO:0031465 Cul4B-RING E3 ubiquitin ligase complex; GO:0031466 Cul5-RING ubiquitin ligase complex; GO:0031467 Cul7-RING ubiquitin ligase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043224 nuclear SCF ubiquitin ligase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0080008 Cul4-RING E3 ubiquitin ligase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008190 eukaryotic initiation factor 4E binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019788 NEDD8 transferase activity; GO:0019899 enzyme binding; GO:0031369 translation initiation factor binding; GO:0031625 ubiquitin protein ligase binding; GO:0034450 ubiquitin-ubiquitin ligase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044877 protein-containing complex binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0097602 cullin family protein binding; GO:0140096 catalytic activity"," acting on a protein;","PF12678","PF12678 RING-H2 zinc finger domain","O","KOG2930","SCF ubiquitin ligase"," Rbx1 component","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME;WP179 CELL CYCLE;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP3300 DUAL HIJACK MODEL OF VIF IN HIV INFECTION;WP4860 HIJACK OF UBIQUITINATION BY SARSCOV2;WP4541 HIPPOMERLIN SIGNALING DYSREGULATION;WP4357 NRF2ARE REGULATION;WP4753 NUCLEOTIDE EXCISION REPAIR;WP5114 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM;WP366 TGFBETA SIGNALING PATHWAY;WP4241 TYPE 2 PAPILLARY RENAL CELL CARCINOMA","http://www.wikipathways.org/instance/WP4657_r120007;http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP3300_r102277;http://www.wikipathways.org/instance/WP4860_r120599;http://www.wikipathways.org/instance/WP4541_r116745;http://www.wikipathways.org/instance/WP4357_r98705;http://www.wikipathways.org/instance/WP4753_r119238;http://www.wikipathways.org/instance/WP5114_r119169;http://www.wikipathways.org/instance/WP366_r120697;http://www.wikipathways.org/instance/WP4241_r106520",null,"R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex;R-HSA-1170546 Prolactin receptor signaling;R-HSA-1234174 Cellular response to hypoxia;R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-180585 Vif-mediated degradation of APOBEC3G;R-HSA-195253 Degradation of beta-catenin by the destruction complex;R-HSA-195721 Signaling by WNT;R-HSA-1980143 Signaling by NOTCH1;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer;R-HSA-2644603 Signaling by NOTCH1 in Cancer;R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer;R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants;R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling;R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer;R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;R-HSA-376176 Signaling by ROBO receptors;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-4641258 Degradation of DVL;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5610780 Degradation of GLI1 by the proteasome;R-HSA-5610783 Degradation of GLI2 by the proteasome;R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome;R-HSA-5610787 Hedgehog 'off' state;R-HSA-5632684 Hedgehog 'on' state;R-HSA-5658442 Regulation of RAS by GAPs;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-5696394 DNA Damage Recognition in GG-NER;R-HSA-5696395 Formation of Incision Complex in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-5696400 Dual Incision in GG-NER;R-HSA-597592 Post-translational protein modification;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-68949 Orc1 removal from chromatin;R-HSA-69052 Switching of origins to a post-replicative state;R-HSA-69239 Synthesis of DNA;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69306 DNA Replication;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73893 DNA Damage Bypass;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis;R-HSA-8878166 Transcriptional regulation by RUNX2;R-HSA-8939902 Regulation of RUNX2 expression and activity;R-HSA-8951664 Neddylation;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-9013694 Signaling by NOTCH4;R-HSA-9020702 Interleukin-1 signaling;R-HSA-9604323 Negative regulation of NOTCH4 signaling;R-HSA-9675108 Nervous system development;R-HSA-9679191 Potential therapeutics for SARS;R-HSA-9679506 SARS-CoV Infections;R-HSA-9700206 Signaling by ALK in cancer;R-HSA-9708530 Regulation of BACH1 activity;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9725370 Signaling by ALK fusions and activated point mutants;R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer;R-HSA-9755511 KEAP1-NFE2L2 pathway;R-HSA-9759194 Nuclear events mediated by NFE2L2;R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation",null,"DNA REPAIR;NOTCH SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_NOTCH_SIGNALING"]
["P62937","Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2","PPIA",1.171847715,5.207143E-3,"up",1564490,1699760,1591910,1870690,1870730,1949260,0.890023931,0.966977787,0.905622916,1.064218287,1.064241043,1.108916036,"cytoplasm","K03767","PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]","hsa03250 Viral life cycle - HIV-1; hsa04217 Necroptosis","GO:0000413 protein peptidyl-prolyl isomerization; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006278 RNA-dependent DNA biosynthetic process; GO:0006457 protein folding; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018208 peptidyl-proline modification; GO:0019042 viral latency; GO:0019043 establishment of viral latency; GO:0019058 viral life cycle; GO:0019061 uncoating of virus; GO:0019064 fusion of virus membrane with host plasma membrane; GO:0019068 virion assembly; GO:0019076 viral release from host cell; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032515 negative regulation of phosphoprotein phosphatase activity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0034097 response to cytokine; GO:0034389 lipid droplet organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035308 negative regulation of protein dephosphorylation; GO:0035722 interleukin-12-mediated signaling pathway; GO:0035890 exit from host; GO:0035891 exit from host cell; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0039663 membrane fusion involved in viral entry into host cell; GO:0040011 locomotion; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044409 entry into host; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044764 multi-organism cellular process; GO:0044803 multi-organism membrane organization; GO:0045055 regulated exocytosis; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0045321 leukocyte activation; GO:0045936 negative regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0046718 viral entry into host cell; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051674 localization of cell; GO:0051701 biological process involved in interaction with host; GO:0051716 cellular response to stimulus; GO:0052126 movement in host environment; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070671 response to interleukin-12; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071349 cellular response to interleukin-12; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0075713 establishment of integrated proviral latency; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:1904951 positive regulation of establishment of protein localization;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0030496 midbody; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen;","GO:0003755 peptidyl-prolyl cis-trans isomerase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016018 cyclosporin A binding; GO:0016853 isomerase activity; GO:0016859 cis-trans isomerase activity; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0046790 virion binding; GO:0051082 unfolded protein binding; GO:0140096 catalytic activity"," acting on a protein;","PF00160","PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD","O","KOG0865","Cyclophilin type peptidyl-prolyl cis-trans isomerase","WP2037 PROLACTIN SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2037_r116779",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR);R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-162585 Uncoating of the HIV Virion;R-HSA-162587 HIV Life Cycle;R-HSA-162588 Budding and maturation of HIV virion;R-HSA-162589 Reverse Transcription of HIV RNA;R-HSA-162592 Integration of provirus;R-HSA-162594 Early Phase of HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1643685 Disease;R-HSA-164516 Minus-strand DNA synthesis;R-HSA-164525 Plus-strand DNA synthesis;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-173107 Binding and entry of HIV virion;R-HSA-175474 Assembly Of The HIV Virion;R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection;R-HSA-2025928 Calcineurin activates NFAT;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-210991 Basigin interactions;R-HSA-447115 Interleukin-12 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-5663205 Infectious disease;R-HSA-6798695 Neutrophil degranulation;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation;R-HSA-9020591 Interleukin-12 signaling;R-HSA-983705 Signaling by the B Cell Receptor (BCR)","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-1168372;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-162585;https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162588;https://reactome.org/PathwayBrowser/#/R-HSA-162589;https://reactome.org/PathwayBrowser/#/R-HSA-162592;https://reactome.org/PathwayBrowser/#/R-HSA-162594;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-162909;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-164516;https://reactome.org/PathwayBrowser/#/R-HSA-164525;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-173107;https://reactome.org/PathwayBrowser/#/R-HSA-175474;https://reactome.org/PathwayBrowser/#/R-HSA-180689;https://reactome.org/PathwayBrowser/#/R-HSA-2025928;https://reactome.org/PathwayBrowser/#/R-HSA-202733;https://reactome.org/PathwayBrowser/#/R-HSA-210991;https://reactome.org/PathwayBrowser/#/R-HSA-447115;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005;https://reactome.org/PathwayBrowser/#/R-HSA-8950505;https://reactome.org/PathwayBrowser/#/R-HSA-9020591;https://reactome.org/PathwayBrowser/#/R-HSA-983705","GLYCOLYSIS;MTORC1 SIGNALING;MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["P63241","Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2","EIF5A",1.060219408,0.050977282,"nochange",293491,285747,286546,294588,314115,309218,0.987240603,0.961191453,0.963879117,0.990930675,1.056615304,1.040142849,"cytoplasm","K03263",null,null,"GO:0000003 reproduction; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006412 translation; GO:0006414 translational elongation; GO:0006417 regulation of translation; GO:0006448 regulation of translational elongation; GO:0006518 peptide metabolic process; GO:0006611 protein export from nucleus; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006915 apoptotic process; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007548 sex differentiation; GO:0007568 aging; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008284 positive regulation of cell population proliferation; GO:0008406 gonad development; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009791 post-embryonic development; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010660 regulation of muscle cell apoptotic process; GO:0010661 positive regulation of muscle cell apoptotic process; GO:0010662 regulation of striated muscle cell apoptotic process; GO:0010663 positive regulation of striated muscle cell apoptotic process; GO:0010665 regulation of cardiac muscle cell apoptotic process; GO:0010666 positive regulation of cardiac muscle cell apoptotic process; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0030003 cellular cation homeostasis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0033036 macromolecule localization; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035262 gonad morphogenesis; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043043 peptide biosynthetic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045137 development of primary sexual characteristics; GO:0045138 nematode male tail tip morphogenesis; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045727 positive regulation of translation; GO:0045901 positive regulation of translational elongation; GO:0046661 male sex differentiation; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051094 positive regulation of developmental process; GO:0051147 regulation of muscle cell differentiation; GO:0051149 positive regulation of muscle cell differentiation; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051480 regulation of cytosolic calcium ion concentration; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071166 ribonucleoprotein complex localization; GO:0071310 cellular response to organic substance; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0080090 regulation of primary metabolic process; GO:0090598 male anatomical structure morphogenesis; GO:0097066 response to thyroid hormone; GO:0097067 cellular response to thyroid hormone stimulus; GO:0098771 inorganic ion homeostasis; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000379 positive regulation of reactive oxygen species metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005642 annulate lamellae; GO:0005643 nuclear pore; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030425 dendrite; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body; GO:0097447 dendritic tree; GO:0098827 endoplasmic reticulum subcompartment; GO:0120025 plasma membrane bounded cell projection;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003746 translation elongation factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0017069 snRNA binding; GO:0017070 U6 snRNA binding; GO:0047485 protein N-terminus binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF01287","PF01287 Eukaryotic elongation factor 5A hypusine"," DNA-binding OB fold","J","KOG3271","Translation initiation factor 5A (eIF-5A)","WP107 TRANSLATION FACTORS","http://www.wikipathways.org/instance/WP107_r117851",null,"R-HSA-163841 Gamma carboxylation"," hypusine formation and arylsulfatase activation;R-HSA-204626 Hypusine synthesis from eIF5A-lysine;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-163841;https://reactome.org/PathwayBrowser/#/R-HSA-204626;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592","ALLOGRAFT REJECTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION"]
["P63279","SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1","UBE2I",1.210126799,0.014795939,"nochange",246114,221602,232604,294194,290151,263131,0.954055961,0.859035687,0.901684718,1.140437112,1.124764504,1.020022018,"cytoplasm","K10577","UBE2I; ubiquitin-conjugating enzyme E2 I","hsa04064 NF-kappa B signaling pathway; hsa03013 Nucleocytoplasmic transport; hsa05206 MicroRNAs in cancer; hsa04120 Ubiquitin mediated proteolysis","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000280 nuclear division; GO:0000578 embryonic axis specification; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001947 heart looping; GO:0002009 morphogenesis of an epithelium; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0003002 regionalization; GO:0003007 heart morphogenesis; GO:0003143 embryonic heart tube morphogenesis; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006606 protein import into nucleus; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006928 movement of cell or subcellular component; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007088 regulation of mitotic nuclear division; GO:0007143 female meiotic nuclear division; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007352 zygotic specification of dorsal/ventral axis; GO:0007368 determination of left/right symmetry; GO:0007389 pattern specification process; GO:0007391 dorsal closure; GO:0007507 heart development; GO:0007517 muscle organ development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008354 germ cell migration; GO:0008592 regulation of Toll signaling pathway; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009799 specification of symmetry; GO:0009855 determination of bilateral symmetry; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009950 dorsal/ventral axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016321 female meiosis chromosome segregation; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0016567 protein ubiquitination; GO:0016925 protein sumoylation; GO:0017038 protein import; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030163 protein catabolic process; GO:0030721 spectrosome organization; GO:0031099 regeneration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway; GO:0033233 regulation of protein sumoylation; GO:0033235 positive regulation of protein sumoylation; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0035050 embryonic heart tube development; GO:0035172 hemocyte proliferation; GO:0035203 regulation of lamellocyte differentiation; GO:0035204 negative regulation of lamellocyte differentiation; GO:0035206 regulation of hemocyte proliferation; GO:0035207 negative regulation of hemocyte proliferation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036211 protein modification process; GO:0036306 embryonic heart tube elongation; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043282 pharyngeal muscle development; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045132 meiotic chromosome segregation; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045610 regulation of hemocyte differentiation; GO:0045611 negative regulation of hemocyte differentiation; GO:0045613 regulation of plasmatocyte differentiation; GO:0045614 negative regulation of plasmatocyte differentiation; GO:0045751 negative regulation of Toll signaling pathway; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048562 embryonic organ morphogenesis; GO:0048565 digestive tract development; GO:0048568 embryonic organ development; GO:0048580 regulation of post-embryonic development; GO:0048581 negative regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0048872 homeostasis of number of cells; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051321 meiotic cell cycle; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0055123 digestive system development; GO:0060216 definitive hemopoiesis; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060465 pharynx development; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0061371 determination of heart left/right asymmetry; GO:0061484 hematopoietic stem cell homeostasis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903046 meiotic cell cycle process; GO:1903182 regulation of SUMO transferase activity; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:1903755 positive regulation of SUMO transferase activity; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000779 condensed chromosome"," centromeric region; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0000795 synaptonemal complex; GO:0000940 outer kinetochore; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016604 nuclear body; GO:0016605 PML body; GO:0030425 dendrite; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0097447 dendritic tree; GO:0098687 chromosomal region; GO:0099086 synaptonemal structure; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1990234 transferase complex; GO:1990356 sumoylated E2 ligase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008134 transcription factor binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019789 SUMO transferase activity; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031072 heat shock protein binding; GO:0032093 SAM domain binding; GO:0033134 ubiquitin activating enzyme binding; GO:0043398 HLH domain binding; GO:0043425 bHLH transcription factor binding; GO:0044388 small protein activating enzyme binding; GO:0061650 ubiquitin-like protein conjugating enzyme activity; GO:0061656 SUMO conjugating enzyme activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0061665 SUMO ligase activity; GO:0071535 RING-like zinc finger domain binding; GO:0140096 catalytic activity"," acting on a protein;","PF00179","PF00179 Ubiquitin-conjugating enzyme","O","KOG0424","Ubiquitin-protein ligase","WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY;WP366 TGFBETA SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP138_r120688;http://www.wikipathways.org/instance/WP366_r120697","Transcription factor","R-HSA-1221632 Meiotic synapsis;R-HSA-1430728 Metabolism;R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-196791 Vitamin D (calciferol) metabolism;R-HSA-212436 Generic Transcription Pathway;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2990846 SUMOylation;R-HSA-2995410 Nuclear Envelope (NE) Reassembly;R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I"," UBC9);R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3215018 Processing and activation of SUMO;R-HSA-3232118 SUMOylation of transcription factors;R-HSA-3232142 SUMOylation of ubiquitinylation proteins;R-HSA-3899300 SUMOylation of transcription cofactors;R-HSA-392499 Metabolism of proteins;R-HSA-4085377 SUMOylation of SUMOylation proteins;R-HSA-4090294 SUMOylation of intracellular receptors;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-4570464 SUMOylation of RNA binding proteins;R-HSA-4615885 SUMOylation of DNA replication proteins;R-HSA-4655427 SUMOylation of DNA methylation proteins;R-HSA-4755510 SUMOylation of immune response proteins;R-HSA-556833 Metabolism of lipids;R-HSA-5663205 Infectious disease;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693538 Homology Directed Repair;R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks;R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA);R-HSA-5693606 DNA Double Strand Break Response;R-HSA-5693607 Processing of DNA double-strand break ends;R-HSA-5696395 Formation of Incision Complex in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-597592 Post-translational protein modification;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors;R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors;R-HSA-8957322 Metabolism of steroids;R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation;R-HSA-9678108 SARS-CoV-1 Infection;R-HSA-9679506 SARS-CoV Infections;R-HSA-9683610 Maturation of nucleoprotein;R-HSA-9683701 Translation of Structural Proteins;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694631 Maturation of nucleoprotein;R-HSA-9694635 Translation of Structural Proteins;R-HSA-9772573 Late SARS-CoV-2 Infection Events",null,"ANDROGEN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE"]
["P78346","Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1","RPP30",0.817736077,0.075057548,"nochange",10225.9,10897.5,13179,9189.27,9908.77,8952.27,0.984005346,1.048631246,1.268172626,0.884253788,0.95348895,0.861448043,"cytoplasm","K03539","RPP1; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000966 RNA 5'-end processing; GO:0001682 tRNA 5'-leader removal; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0034470 ncRNA processing; GO:0034471 ncRNA 5'-end processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090502 RNA phosphodiester bond hydrolysis"," endonucleolytic; GO:0099116 tRNA 5'-end processing; GO:1901360 organic cyclic compound metabolic process;","GO:0000172 ribonuclease MRP complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005655 nucleolar ribonuclease P complex; GO:0005730 nucleolus; GO:0005732 sno(s)RNA-containing ribonucleoprotein complex; GO:0030677 ribonuclease P complex; GO:0030681 multimeric ribonuclease P complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1902555 endoribonuclease complex; GO:1905348 endonuclease complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0004521 endoribonuclease activity; GO:0004526 ribonuclease P activity; GO:0004540 ribonuclease activity; GO:0004549 tRNA-specific ribonuclease activity; GO:0005488 binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016891 endoribonuclease activity"," producing 5'-phosphomonoesters; GO:0016893 endonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA; GO:1901363 heterocyclic compound binding;","PF01876","PF01876 RNase P subunit p30","J","KOG2363","Protein subunit of nuclear ribonuclease P (RNase P)",{"$nulls":3},"R-HSA-6784531 tRNA processing in the nucleus;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72306 tRNA processing;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6784531;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72306;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["P78527","DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3","PRKDC",0.868729657,0.000403782,"down",209335,212061,213637,183321,187808,180543,1.058401203,1.072183904,1.080152186,0.926873991,0.949560337,0.912828378,"cytoplasm","K06642","PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]","hsa03450 Non-homologous end-joining; hsa04110 Cell cycle","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0001756 somitogenesis; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002200 somatic diversification of immune receptors; GO:0002218 activation of innate immune response; GO:0002244 hematopoietic progenitor cell differentiation; GO:0002253 activation of immune response; GO:0002320 lymphoid progenitor cell differentiation; GO:0002326 B cell lineage commitment; GO:0002328 pro-B cell differentiation; GO:0002360 T cell lineage commitment; GO:0002376 immune system process; GO:0002377 immunoglobulin production; GO:0002440 production of molecular mediator of immune response; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus; GO:0002568 somatic diversification of T cell receptor genes; GO:0002637 regulation of immunoglobulin production; GO:0002638 negative regulation of immunoglobulin production; GO:0002681 somatic recombination of T cell receptor gene segments; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002698 negative regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002701 negative regulation of production of molecular mediator of immune response; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006310 DNA recombination; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008284 positive regulation of cell population proliferation; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010212 response to ionizing radiation; GO:0010243 response to organonitrogen compound; GO:0010332 response to gamma radiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010623 programmed cell death involved in cell development; GO:0010628 positive regulation of gene expression; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016233 telomere capping; GO:0016310 phosphorylation; GO:0016444 somatic cell DNA recombination; GO:0016445 somatic diversification of immunoglobulins; GO:0016447 somatic recombination of immunoglobulin gene segments; GO:0016567 protein ubiquitination; GO:0018105 peptidyl-serine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030183 B cell differentiation; GO:0030217 T cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0031647 regulation of protein stability; GO:0031648 protein destabilization; GO:0032200 telomere organization; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0033077 T cell differentiation in thymus; GO:0033151 V(D)J recombination; GO:0033152 immunoglobulin V(D)J recombination; GO:0033153 T cell receptor V(D)J recombination; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0035234 ectopic germ cell programmed cell death; GO:0035282 segmentation; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0042110 T cell activation; GO:0042113 B cell activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042752 regulation of circadian rhythm; GO:0042770 signal transduction in response to DNA damage; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045165 cell fate commitment; GO:0045321 leukocyte activation; GO:0045786 negative regulation of cell cycle; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046649 lymphocyte activation; GO:0048145 regulation of fibroblast proliferation; GO:0048146 positive regulation of fibroblast proliferation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048536 spleen development; GO:0048538 thymus development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0061053 somite development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0090342 regulation of cell aging; GO:0090344 negative regulation of cell aging; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097681 double-strand break repair via alternative nonhomologous end joining; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2000772 regulation of cellular senescence; GO:2000773 negative regulation of cellular senescence; GO:2001141 regulation of RNA biosynthetic process; GO:2001228 regulation of response to gamma radiation; GO:2001229 negative regulation of response to gamma radiation;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070419 nonhomologous end joining complex; GO:1990391 DNA repair complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004677 DNA-dependent protein kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;","PF08163","PF08163 DNA-dependent protein kinase catalytic subunit"," CC3","L","KOG0891","DNA-dependent protein kinase","WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE;WP179 CELL CYCLE;WP3594 CIRCADIAN RHYTHM GENES;WP707 DNA DAMAGE RESPONSE;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR;WP3959 DNA IRDOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP314 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS;WP1530 MIRNA REGULATION OF DNA DAMAGE RESPONSE;WP438 NONHOMOLOGOUS END JOINING;WP4787 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES;WP3651 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA;WP2446 RETINOBLASTOMA GENE IN CANCER","http://www.wikipathways.org/instance/WP3878_r117656;http://www.wikipathways.org/instance/WP179_r120742;http://www.wikipathways.org/instance/WP3594_r117682;http://www.wikipathways.org/instance/WP707_r116541;http://www.wikipathways.org/instance/WP4016_r120667;http://www.wikipathways.org/instance/WP3959_r118468;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP314_r116694;http://www.wikipathways.org/instance/WP1530_r118120;http://www.wikipathways.org/instance/WP438_r119305;http://www.wikipathways.org/instance/WP4787_r118872;http://www.wikipathways.org/instance/WP3651_r116547;http://www.wikipathways.org/instance/WP2446_r116593","Transcription factor","R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1834941 STING mediated induction of host immune responses;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-3270619 IRF3-mediated induction of type I IFN;R-HSA-392499 Metabolism of proteins;R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693571 Nonhomologous End-Joining (NHEJ);R-HSA-597592 Post-translational protein modification;R-HSA-73894 DNA Repair;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1834941;https://reactome.org/PathwayBrowser/#/R-HSA-1834949;https://reactome.org/PathwayBrowser/#/R-HSA-3270619;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693571;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["P80217","Interferon-induced 35 kDa protein OS=Homo sapiens OX=9606 GN=IFI35 PE=1 SV=5","IFI35",0.855259721,0.013962615,"nochange",49643,45393.9,47749.2,38536.9,41880.2,41702.1,1.124394265,1.028153835,1.081500446,0.872845504,0.948569923,0.944536029,"cytoplasm",{"$nulls":3},"GO:0002376 immune system process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0019221 cytokine-mediated signaling pathway; GO:0023052 signaling; GO:0034097 response to cytokine; GO:0034340 response to type I interferon; GO:0042221 response to chemical; GO:0045087 innate immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060337 type I interferon signaling pathway; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071357 cellular response to type I interferon;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",null,"PF07292","PF07292 Nmi/IFP 35 domain (NID)",{"$nulls":3},"WP4197 IMMUNE RESPONSE TO TUBERCULOSIS","http://www.wikipathways.org/instance/WP4197_r120647",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-168256 Immune System;R-HSA-909733 Interferon alpha/beta signaling;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-909733;https://reactome.org/PathwayBrowser/#/R-HSA-913531","INTERFERON ALPHA RESPONSE;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["P84085","ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2","ARF5",1.215269361,0.002940487,"up",147236,142412,134430,175206,173133,167030,0.940357466,0.909547851,0.858568924,1.118994472,1.105754768,1.066776519,"mitochondria","K07940","ARF5; ADP-ribosylation factor 5","hsa04144 Endocytosis","GO:0000003 reproduction; GO:0001505 regulation of neurotransmitter levels; GO:0001654 eye development; GO:0003006 developmental process involved in reproduction; GO:0006464 cellular protein modification process; GO:0006471 protein ADP-ribosylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0006897 endocytosis; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016192 vesicle-mediated transport; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0023061 signal release; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0036211 protein modification process; GO:0036465 synaptic vesicle recycling; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0046903 secretion; GO:0048193 Golgi vesicle transport; GO:0048468 cell development; GO:0048488 synaptic vesicle endocytosis; GO:0048513 animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity; GO:0005488 binding; GO:0005525 GTP binding; GO:0016462 pyrophosphatase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016763 pentosyltransferase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00025","PF00025 ADP-ribosylation factor family","U","KOG0070","GTP-binding ADP-ribosylation factor Arf1",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["P98095","Fibulin-2 OS=Homo sapiens OX=9606 GN=FBLN2 PE=1 SV=2","FBLN2",0.793657324,0.218362925,"nochange",2162.3,2394.85,1932.54,1406.03,1428.9,2315.66,1.114560818,1.234429069,0.996130677,0.724740298,0.736528675,1.193610463,"extracellular","K17307",null,null,"GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007162 negative regulation of cell adhesion; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0009611 response to wounding; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030155 regulation of cell adhesion; GO:0030198 extracellular matrix organization; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042060 wound healing; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043062 extracellular structure organization; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044238 primary metabolic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045785 positive regulation of cell adhesion; GO:0045936 negative regulation of phosphate metabolic process; GO:0048145 regulation of fibroblast proliferation; GO:0048146 positive regulation of fibroblast proliferation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070372 regulation of ERK1 and ERK2 cascade; GO:0070373 negative regulation of ERK1 and ERK2 cascade; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072091 regulation of stem cell proliferation; GO:0072376 protein activation cascade; GO:0072378 blood coagulation"," fibrin clot formation; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:1900024 regulation of substrate adhesion-dependent cell spreading; GO:1900025 negative regulation of substrate adhesion-dependent cell spreading; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904187 regulation of transformation of host cell by virus; GO:1904188 negative regulation of transformation of host cell by virus; GO:1904235 regulation of substrate-dependent cell migration"," cell attachment to substrate; GO:1904237 positive regulation of substrate-dependent cell migration"," cell attachment to substrate; GO:1904950 negative regulation of establishment of protein localization; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000647 negative regulation of stem cell proliferation;","GO:0005576 extracellular region; GO:0005604 basement membrane; GO:0005615 extracellular space; GO:0031012 extracellular matrix; GO:0062023 collagen-containing extracellular matrix; GO:0071953 elastic fiber;","GO:0001968 fibronectin binding; GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005198 structural molecule activity; GO:0005201 extracellular matrix structural constituent; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044877 protein-containing complex binding; GO:0046872 metal ion binding; GO:0050839 cell adhesion molecule binding; GO:0050840 extracellular matrix binding; GO:0070051 fibrinogen binding;","PF01821; PF14670; PF07645; PF12662","PF01821 Anaphylotoxin-like domain; PF14670 Coagulation Factor Xa inhibitory site; PF07645 Calcium-binding EGF domain; PF12662 Complement Clr-like EGF-like","T","KOG1217","Fibrillins and related proteins containing Ca2+-binding EGF-like domains","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4932_r118797",null,"R-HSA-1474244 Extracellular matrix organization;R-HSA-1566948 Elastic fibre formation;R-HSA-2129379 Molecules associated with elastic fibres","https://reactome.org/PathwayBrowser/#/R-HSA-1474244;https://reactome.org/PathwayBrowser/#/R-HSA-1566948;https://reactome.org/PathwayBrowser/#/R-HSA-2129379","EPITHELIAL MESENCHYMAL TRANSITION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"]
["Q00610","Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5","CLTC",1.262903867,{"v":5.25401e-05,"d":"5.25E-05"},"up",174168,170056,173954,219744,220875,213790,0.891198691,0.870158035,0.890103677,1.124406121,1.130193325,1.093940151,"cytoplasm","K04646","CLTC; clathrin heavy chain","hsa04961 Endocrine and other factor-regulated calcium reabsorption; hsa05100 Bacterial invasion of epithelial cells; hsa04721 Synaptic vesicle cycle; hsa04142 Lysosome; hsa05016 Huntington disease; hsa04144 Endocytosis","GO:0000003 reproduction; GO:0000041 transition metal ion transport; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000578 embryonic axis specification; GO:0001505 regulation of neurotransmitter levels; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0002376 immune system process; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006109 regulation of carbohydrate metabolic process; GO:0006403 RNA localization; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006826 iron ion transport; GO:0006836 neurotransmitter transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007028 cytoplasm organization; GO:0007030 Golgi organization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007291 sperm individualization; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007316 pole plasm RNA localization; GO:0007346 regulation of mitotic cell cycle; GO:0007349 cellularization; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007568 aging; GO:0007591 molting cycle"," chitin-based cuticle; GO:0007594 puparial adhesion; GO:0008103 oocyte microtubule cytoskeleton polarization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008298 intracellular mRNA localization; GO:0008340 determination of adult lifespan; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008593 regulation of Notch signaling pathway; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010256 endomembrane system organization; GO:0010259 multicellular organism aging; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010623 programmed cell death involved in cell development; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016055 Wnt signaling pathway; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016325 oocyte microtubule cytoskeleton organization; GO:0016482 cytosolic transport; GO:0017156 calcium-ion regulated exocytosis; GO:0019094 pole plasm mRNA localization; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0022608 multicellular organism adhesion; GO:0022609 multicellular organism adhesion to substrate; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023061 signal release; GO:0030001 metal ion transport; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030198 extracellular matrix organization; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity; GO:0030952 establishment or maintenance of cytoskeleton polarity; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031623 receptor internalization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032799 low-density lipoprotein receptor particle metabolic process; GO:0032801 receptor catabolic process; GO:0032802 low-density lipoprotein particle receptor catabolic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032881 regulation of polysaccharide metabolic process; GO:0032885 regulation of polysaccharide biosynthetic process; GO:0032886 regulation of microtubule-based process; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033227 dsRNA transport; GO:0033363 secretory granule organization; GO:0033572 transferrin transport; GO:0034381 plasma lipoprotein particle clearance; GO:0034383 low-density lipoprotein particle clearance; GO:0034613 cellular protein localization; GO:0035002 liquid clearance"," open tracheal system; GO:0035150 regulation of tube size; GO:0035151 regulation of tube size"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035159 regulation of tube length"," open tracheal system; GO:0035282 segmentation; GO:0035567 non-canonical Wnt signaling pathway; GO:0040008 regulation of growth; GO:0042044 fluid transport; GO:0042045 epithelial fluid transport; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042303 molting cycle; GO:0042886 amide transport; GO:0043062 extracellular structure organization; GO:0043112 receptor metabolic process; GO:0043170 macromolecule metabolic process; GO:0043255 regulation of carbohydrate biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045056 transcytosis; GO:0045176 apical protein localization; GO:0045184 establishment of protein localization; GO:0045451 pole plasm oskar mRNA localization; GO:0045747 positive regulation of Notch signaling pathway; GO:0045807 positive regulation of endocytosis; GO:0045912 negative regulation of carbohydrate metabolic process; GO:0046666 retinal cell programmed cell death; GO:0046667 compound eye retinal cell programmed cell death; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048232 male gamete generation; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048268 clathrin coat assembly; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051239 regulation of multicellular organismal process; GO:0051493 regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060071 Wnt signaling pathway"," planar cell polarity pathway; GO:0060236 regulation of mitotic spindle organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060541 respiratory system development; GO:0060627 regulation of vesicle-mediated transport; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0061024 membrane organization; GO:0062012 regulation of small molecule metabolic process; GO:0062014 negative regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070633 transepithelial transport; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072583 clathrin-dependent endocytosis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090175 regulation of establishment of planar polarity; GO:0090224 regulation of spindle organization; GO:0090307 mitotic spindle assembly; GO:0090596 sensory organ morphogenesis; GO:0097006 regulation of plasma lipoprotein particle levels; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0140014 mitotic nuclear division; GO:0198738 cell-cell signaling by wnt; GO:1900125 regulation of hyaluronan biosynthetic process; GO:1900126 negative regulation of hyaluronan biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1903076 regulation of protein localization to plasma membrane; GO:1903077 negative regulation of protein localization to plasma membrane; GO:1903828 negative regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904376 negative regulation of protein localization to cell periphery; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:1905330 regulation of morphogenesis of an epithelium; GO:1905475 regulation of protein localization to membrane; GO:1905476 negative regulation of protein localization to membrane; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000369 regulation of clathrin-dependent endocytosis; GO:2000370 positive regulation of clathrin-dependent endocytosis;","GO:0000139 Golgi membrane; GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005768 endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0005886 plasma membrane; GO:0005905 clathrin-coated pit; GO:0005938 cell cortex; GO:0009898 cytoplasmic side of plasma membrane; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0030117 membrane coat; GO:0030118 clathrin coat; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0030141 secretory granule; GO:0030315 T-tubule; GO:0030424 axon; GO:0030659 cytoplasmic vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030665 clathrin-coated vesicle membrane; GO:0030666 endocytic vesicle membrane; GO:0030669 clathrin-coated endocytic vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031523 Myb complex; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0036019 endolysosome; GO:0036020 endolysosome membrane; GO:0042383 sarcolemma; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045177 apical part of cell; GO:0045202 synapse; GO:0045334 clathrin-coated endocytic vesicle; GO:0048471 perinuclear region of cytoplasm; GO:0048475 coated membrane; GO:0071439 clathrin complex; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098796 membrane protein complex; GO:0098852 lytic vacuole membrane; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1990498 mitotic spindle microtubule;","GO:0002020 protease binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003725 double-stranded RNA binding; GO:0005102 signaling receptor binding; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008022 protein C-terminus binding; GO:0008092 cytoskeletal protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030276 clathrin binding; GO:0030506 ankyrin binding; GO:0031072 heat shock protein binding; GO:0032051 clathrin light chain binding; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0042802 identical protein binding; GO:0050750 low-density lipoprotein particle receptor binding; GO:0070325 lipoprotein particle receptor binding; GO:0097159 organic cyclic compound binding; GO:0097718 disordered domain specific binding; GO:1901363 heterocyclic compound binding; GO:1990381 ubiquitin-specific protease binding; GO:1990763 arrestin family protein binding;",null,null,"U","KOG0985","Vesicle coat protein clathrin"," heavy chain","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP558 COMPLEMENT AND COAGULATION CASCADES;WP4217 EBOLA VIRUS INFECTION IN HOST;WP4549 FRAGILE X SYNDROME;WP2267 SYNAPTIC VESICLE PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP558_r119232;http://www.wikipathways.org/instance/WP4217_r120623;http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP2267_r117179;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1266738 Developmental Biology;R-HSA-1280218 Adaptive Immune System;R-HSA-157858 Gap junction trafficking and regulation;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166520 Signaling by NTRKs;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis;R-HSA-174824 Plasma lipoprotein assembly"," remodeling"," and clearance;R-HSA-177504 Retrograde neurotrophin signalling;R-HSA-187037 Signaling by NTRK1 (TRKA);R-HSA-190828 Gap junction trafficking;R-HSA-190873 Gap junction degradation;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195721 Signaling by WNT;R-HSA-196025 Formation of annular gap junctions;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-2132295 MHC class II antigen presentation;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-373760 L1CAM interactions;R-HSA-382551 Transport of small molecules;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-3928665 EPH-ephrin mediated repulsion of cells;R-HSA-4086400 PCP/CE pathway;R-HSA-422475 Axon guidance;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-437239 Recycling pathway of L1;R-HSA-5099900 WNT5A-dependent internalization of FZD4;R-HSA-5140745 WNT5A-dependent internalization of FZD2"," FZD5 and ROR2;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-8866427 VLDLR internalisation and degradation;R-HSA-8964038 LDL clearance;R-HSA-8964043 Plasma lipoprotein clearance;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013424 RHOV GTPase cycle;R-HSA-9675108 Nervous system development;R-HSA-9700206 Signaling by ALK in cancer;R-HSA-9700645 ALK mutants bind TKIs;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-9725370 Signaling by ALK fusions and activated point mutants;R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer",null,"PI3K AKT MTOR SIGNALING;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["Q01432","AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1","AMPD3",0.812569305,0.019639539,"nochange",9825.4,8798.4,8610.96,7694.29,6847.12,7588.72,1.194217186,1.069391626,1.046609442,0.935193819,0.832225495,0.922362432,"cytoplasm","K01490","AMPD; AMP deaminase [EC:3.5.4.6]","hsa01232 Nucleotide metabolism; hsa00230 Purine metabolism; hsa01100 Metabolic pathways","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002262 myeloid cell homeostasis; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006188 IMP biosynthetic process; GO:0006195 purine nucleotide catabolic process; GO:0006196 AMP catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009116 nucleoside metabolic process; GO:0009117 nucleotide metabolic process; GO:0009119 ribonucleoside metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009125 nucleoside monophosphate catabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009128 purine nucleoside monophosphate catabolic process; GO:0009132 nucleoside diphosphate metabolic process; GO:0009135 purine nucleoside diphosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009154 purine ribonucleotide catabolic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009158 ribonucleoside monophosphate catabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009166 nucleotide catabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009169 purine ribonucleoside monophosphate catabolic process; GO:0009179 purine ribonucleoside diphosphate metabolic process; GO:0009185 ribonucleoside diphosphate metabolic process; GO:0009187 cyclic nucleotide metabolic process; GO:0009190 cyclic nucleotide biosynthetic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009261 ribonucleotide catabolic process; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0032501 multicellular organismal process; GO:0032940 secretion by cell; GO:0034101 erythrocyte homeostasis; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042278 purine nucleoside metabolic process; GO:0042592 homeostatic process; GO:0043094 cellular metabolic compound salvage; GO:0043101 purine-containing compound salvage; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046031 ADP metabolic process; GO:0046033 AMP metabolic process; GO:0046034 ATP metabolic process; GO:0046039 GTP metabolic process; GO:0046040 IMP metabolic process; GO:0046128 purine ribonucleoside metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0046903 secretion; GO:0048871 multicellular organismal homeostasis; GO:0048872 homeostasis of number of cells; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0052652 cyclic purine nucleotide metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072523 purine-containing compound catabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097009 energy homeostasis; GO:1901068 guanosine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901657 glycosyl compound metabolic process;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen;","GO:0003824 catalytic activity; GO:0003876 AMP deaminase activity; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016814 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in cyclic amidines; GO:0019239 deaminase activity; GO:0047623 adenosine-phosphate deaminase activity;","PF19326","PF19326 AMP deaminase","F","KOG1096","Adenosine monophosphate deaminase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation;R-HSA-74217 Purine salvage;R-HSA-8956321 Nucleotide salvage","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-74217;https://reactome.org/PathwayBrowser/#/R-HSA-8956321","HYPOXIA","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA"]
["Q01518","Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5","CAP1",1.320985653,0.000101978,"up",257879,258258,248757,339478,328181,342755,0.871552429,0.872833334,0.840722849,1.147332181,1.109151764,1.158407443,"cytoplasm","K17261",null,null,"GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007190 activation of adenylate cyclase activity; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007447 imaginal disc pattern formation; GO:0007450 dorsal/ventral pattern formation"," imaginal disc; GO:0008103 oocyte microtubule cytoskeleton polarization; GO:0008154 actin polymerization or depolymerization; GO:0008360 regulation of cell shape; GO:0008407 chaeta morphogenesis; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016325 oocyte microtubule cytoskeleton organization; GO:0016477 cell migration; GO:0019725 cellular homeostasis; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity; GO:0030952 establishment or maintenance of cytoskeleton polarity; GO:0031175 neuron projection development; GO:0031279 regulation of cyclase activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0035220 wing disc development; GO:0035222 wing disc pattern formation; GO:0035295 tube development; GO:0036230 granulocyte activation; GO:0040011 locomotion; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0042592 homeostatic process; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045761 regulation of adenylate cyclase activity; GO:0046530 photoreceptor cell differentiation; GO:0046716 muscle cell cellular homeostasis; GO:0046903 secretion; GO:0048190 wing disc dorsal/ventral pattern formation; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048592 eye morphogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051339 regulation of lyase activity; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060249 anatomical structure homeostasis; GO:0060429 epithelium development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0072499 photoreceptor cell axon guidance; GO:0090596 sensory organ morphogenesis; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0098657 import into cell; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0030141 secretory granule; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0099568 cytoplasmic region;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008179 adenylate cyclase binding; GO:0019899 enzyme binding; GO:0042802 identical protein binding;",null,null,"ZT","KOG2675","Adenylate cyclase-associated protein (CAP/Srv2p)","WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP5090 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY;WP481 INSULIN SIGNALING","http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP5090_r118898;http://www.wikipathways.org/instance/WP481_r120562",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-1266738 Developmental Biology;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-376176 Signaling by ROBO receptors;R-HSA-422475 Axon guidance;R-HSA-428890 Role of ABL in ROBO-SLIT signaling;R-HSA-6798695 Neutrophil degranulation;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+;R-HSA-9675108 Nervous system development","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-428890;https://reactome.org/PathwayBrowser/#/R-HSA-6798695;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005;https://reactome.org/PathwayBrowser/#/R-HSA-9675108","APICAL JUNCTION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION"]
["Q01826","DNA-binding protein SATB1 OS=Homo sapiens OX=9606 GN=SATB1 PE=1 SV=1","SATB1",0.774087357,0.018669407,"nochange",17076.1,17952.8,19620.1,15592.2,13681,13029.9,1.056775459,1.111031117,1.214214029,0.964942482,0.846665518,0.806371394,"nucleus","K23225",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001775 cell activation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008283 cell population proliferation; GO:0008544 epidermis development; GO:0009605 response to external stimulus; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030217 T cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032259 methylation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032943 mononuclear cell proliferation; GO:0035710 CD4-positive"," alpha-beta T cell activation; GO:0036037 CD8-positive"," alpha-beta T cell activation; GO:0036211 protein modification process; GO:0042098 T cell proliferation; GO:0042110 T cell activation; GO:0043170 macromolecule metabolic process; GO:0043367 CD4-positive"," alpha-beta T cell differentiation; GO:0043374 CD8-positive"," alpha-beta T cell differentiation; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045321 leukocyte activation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046631 alpha-beta T cell activation; GO:0046632 alpha-beta T cell differentiation; GO:0046649 lymphocyte activation; GO:0046651 lymphocyte proliferation; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050798 activated T cell proliferation; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060004 reflex; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070661 leukocyte proliferation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0016363 nuclear matrix; GO:0016604 nuclear body; GO:0016605 PML body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF16534; PF16557; PF02376; PF00046","PF16534 Ubiquitin-like oligomerisation domain of SATB; PF16557 CUT1-like DNA-binding domain of SATB; PF02376 CUT domain; PF00046 Homeodomain","K","KOG3755","SATB1 matrix attachment region binding protein","WP2877 VITAMIN D RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP2877_r119905","Transcription factor","R-HSA-109581 Apoptosis;R-HSA-111465 Apoptotic cleavage of cellular proteins;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-392499 Metabolism of proteins;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-5357801 Programmed Cell Death;R-HSA-597592 Post-translational protein modification;R-HSA-75153 Apoptotic execution phase","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-111465;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4551638;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-75153","APOPTOSIS;KRAS SIGNALING UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APOPTOSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP"]
["Q02742","Beta-1","3-galactosyl-O-glycosyl-glycoprotein beta-1","6-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=GCNT1 PE=1 SV=2","GCNT1",1.080858198,0.869284161,"nochange",4684.82,6063.75,"NA",3834.99,7479.84,6111.69,0.831376226,1.076083519,"NA",0.680563931,1.32738529,1.084591034,"plasma membrane","K00727","GCNT1; beta-1","3-galactosyl-O-glycosyl-glycoprotein beta-1","6-N-acetylglucosaminyltransferase [EC:2.4.1.102]","hsa00512 Mucin type O-glycan biosynthesis; hsa01100 Metabolic pathways","GO:0001655 urogenital system development; GO:0001822 kidney development; GO:0002376 immune system process; GO:0005975 carbohydrate metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0007155 cell adhesion; GO:0007159 leukocyte cell-cell adhesion; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0016266 O-glycan processing; GO:0016477 cell migration; GO:0019538 protein metabolic process; GO:0022610 biological adhesion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045123 cellular extravasation; GO:0048513 animal organ development; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050900 leukocyte migration; GO:0050901 leukocyte tethering or rolling; GO:0051179 localization; GO:0051674 localization of cell; GO:0060352 cell adhesion molecule production; GO:0060993 kidney morphogenesis; GO:0061756 leukocyte adhesion to vascular endothelial cell; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0072001 renal system development; GO:0098609 cell-cell adhesion; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000139 Golgi membrane; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005802 trans-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0003829 beta-1","3-galactosyl-O-glycosyl-glycoprotein beta-1","6-N-acetylglucosaminyltransferase activity; GO:0008109 N-acetyllactosaminide beta-1","6-N-acetylglucosaminyltransferase activity; GO:0008194 UDP-glycosyltransferase activity; GO:0008375 acetylglucosaminyltransferase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0140096 catalytic activity"," acting on a protein; GO:0140103 catalytic activity"," acting on a glycoprotein;",null,null,"G","KOG0799","Branching enzyme",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5173105 O-linked glycosylation;R-HSA-597592 Post-translational protein modification;R-HSA-913709 O-linked glycosylation of mucins","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5173105;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-913709","ALLOGRAFT REJECTION;UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["Q03468","DNA excision repair protein ERCC-6 OS=Homo sapiens OX=9606 GN=ERCC6 PE=1 SV=1","ERCC6",0.486479504,0.007822502,"down",2882.79,2325.05,2339.96,"NA",1114.92,1332.98,1.442015066,1.163025101,1.170483308,"NA",0.557699811,0.666776714,"nucleus","K10841","ERCC6; DNA excision repair protein ERCC-6","hsa03420 Nucleotide excision repair","GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006284 base-excision repair; GO:0006289 nucleotide-excision repair; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006979 response to oxidative stress; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009650 UV protection; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032774 RNA biosynthetic process; GO:0032784 regulation of DNA-templated transcription"," elongation; GO:0032786 positive regulation of DNA-templated transcription"," elongation; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0040029 regulation of gene expression"," epigenetic; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043549 regulation of kinase activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061098 positive regulation of protein tyrosine kinase activity; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0008023 transcription elongation factor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008022 protein C-terminus binding; GO:0008047 enzyme activator activity; GO:0008094 ATP-dependent activity"," acting on DNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019207 kinase regulator activity; GO:0019209 kinase activator activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030295 protein kinase activator activity; GO:0030296 protein tyrosine kinase activator activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0047485 protein N-terminus binding; GO:0070063 RNA polymerase binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0098772 molecular function regulator; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00176; PF00271","PF00176 SNF2-related domain; PF00271 Helicase conserved C-terminal domain","KL","KOG0387","Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain)","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP4753 NUCLEOTIDE EXCISION REPAIR;WP5114 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM","http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP4753_r119238;http://www.wikipathways.org/instance/WP5114_r119169","Transcription factor","R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression;R-HSA-5250913 Positive epigenetic regulation of rRNA expression;R-HSA-5250924 B-WICH complex positively regulates rRNA expression;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-73762 RNA Polymerase I Transcription Initiation;R-HSA-73854 RNA Polymerase I Promoter Clearance;R-HSA-73864 RNA Polymerase I Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-427389;https://reactome.org/PathwayBrowser/#/R-HSA-5250913;https://reactome.org/PathwayBrowser/#/R-HSA-5250924;https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-6781823;https://reactome.org/PathwayBrowser/#/R-HSA-6781827;https://reactome.org/PathwayBrowser/#/R-HSA-6782135;https://reactome.org/PathwayBrowser/#/R-HSA-6782210;https://reactome.org/PathwayBrowser/#/R-HSA-73762;https://reactome.org/PathwayBrowser/#/R-HSA-73854;https://reactome.org/PathwayBrowser/#/R-HSA-73864;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["Q04656","Copper-transporting ATPase 1 OS=Homo sapiens OX=9606 GN=ATP7A PE=1 SV=4","ATP7A",0.773136127,0.056085118,"nochange",2560.77,2764.78,2742.46,1698.64,2249.54,2289.49,1.074022346,1.159586961,1.150225645,0.712433103,0.943488181,0.960243763,"plasma membrane","K17686","copA; P-type Cu+ transporter [EC:7.2.2.8]","hsa04978 Mineral absorption; hsa01524 Platinum drug resistance","GO:0000041 transition metal ion transport; GO:0000302 response to reactive oxygen species; GO:0000303 response to superoxide; GO:0000305 response to oxygen radical; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001101 response to acid chemical; GO:0001501 skeletal system development; GO:0001505 regulation of neurotransmitter levels; GO:0001568 blood vessel development; GO:0001666 response to hypoxia; GO:0001701 in utero embryonic development; GO:0001775 cell activation; GO:0001836 release of cytochrome c from mitochondria; GO:0001889 liver development; GO:0001942 hair follicle development; GO:0001944 vasculature development; GO:0001974 blood vessel remodeling; GO:0002009 morphogenesis of an epithelium; GO:0002082 regulation of oxidative phosphorylation; GO:0002164 larval development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002285 lymphocyte activation involved in immune response; GO:0002286 T cell activation involved in immune response; GO:0002287 alpha-beta T cell activation involved in immune response; GO:0002292 T cell differentiation involved in immune response; GO:0002293 alpha-beta T cell differentiation involved in immune response; GO:0002294 CD4-positive"," alpha-beta T cell differentiation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006464 cellular protein modification process; GO:0006520 cellular amino acid metabolic process; GO:0006568 tryptophan metabolic process; GO:0006570 tyrosine metabolic process; GO:0006576 cellular biogenic amine metabolic process; GO:0006584 catecholamine metabolic process; GO:0006586 indolalkylamine metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006801 superoxide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006825 copper ion transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006878 cellular copper ion homeostasis; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006955 immune response; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007589 body fluid secretion; GO:0007591 molting cycle"," chitin-based cuticle; GO:0007593 chitin-based cuticle sclerotization; GO:0007595 lactation; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008284 positive regulation of cell population proliferation; GO:0008361 regulation of cell size; GO:0008544 epidermis development; GO:0008637 apoptotic mitochondrial changes; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009072 aromatic amino acid family metabolic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009308 amine metabolic process; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009712 catechol-containing compound metabolic process; GO:0009713 catechol-containing compound biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010039 response to iron ion; GO:0010041 response to iron(III) ion; GO:0010042 response to manganese ion; GO:0010043 response to zinc ion; GO:0010155 regulation of proton transport; GO:0010243 response to organonitrogen compound; GO:0010273 detoxification of copper ion; GO:0010288 response to lead ion; GO:0010468 regulation of gene expression; GO:0010591 regulation of lamellipodium assembly; GO:0010592 positive regulation of lamellipodium assembly; GO:0010941 regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0012501 programmed cell death; GO:0014910 regulation of smooth muscle cell migration; GO:0014911 positive regulation of smooth muscle cell migration; GO:0015677 copper ion import; GO:0015679 plasma membrane copper ion transport; GO:0016043 cellular component organization; GO:0016358 dendrite development; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018958 phenol-containing compound metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019430 removal of superoxide radicals; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019725 cellular homeostasis; GO:0019752 carboxylic acid metabolic process; GO:0021533 cell differentiation in hindbrain; GO:0021549 cerebellum development; GO:0021575 hindbrain morphogenesis; GO:0021587 cerebellum morphogenesis; GO:0021680 cerebellar Purkinje cell layer development; GO:0021692 cerebellar Purkinje cell layer morphogenesis; GO:0021694 cerebellar Purkinje cell layer formation; GO:0021695 cerebellar cortex development; GO:0021696 cerebellar cortex morphogenesis; GO:0021697 cerebellar cortex formation; GO:0021700 developmental maturation; GO:0021702 cerebellar Purkinje cell differentiation; GO:0021859 pyramidal neuron differentiation; GO:0021860 pyramidal neuron development; GO:0021872 forebrain generation of neurons; GO:0021879 forebrain neuron differentiation; GO:0021884 forebrain neuron development; GO:0021953 central nervous system neuron differentiation; GO:0021954 central nervous system neuron development; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0022404 molting cycle process; GO:0022405 hair cycle process; GO:0022607 cellular component assembly; GO:0022898 regulation of transmembrane transporter activity; GO:0023052 signaling; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030030 cell projection organization; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030198 extracellular matrix organization; GO:0030199 collagen fibril organization; GO:0030217 T cell differentiation; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030879 mammary gland development; GO:0030900 forebrain development; GO:0030902 hindbrain development; GO:0031069 hair follicle morphogenesis; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032025 response to cobalt ion; GO:0032409 regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033554 cellular response to stress; GO:0034220 ion transmembrane transport; GO:0034599 cellular response to oxidative stress; GO:0034614 cellular response to reactive oxygen species; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034756 regulation of iron ion transport; GO:0034757 negative regulation of iron ion transport; GO:0034759 regulation of iron ion transmembrane transport; GO:0034760 negative regulation of iron ion transmembrane transport; GO:0034762 regulation of transmembrane transport; GO:0034763 negative regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034766 negative regulation of ion transmembrane transport; GO:0035295 tube development; GO:0035434 copper ion transmembrane transport; GO:0035710 CD4-positive"," alpha-beta T cell activation; GO:0036119 response to platelet-derived growth factor; GO:0036120 cellular response to platelet-derived growth factor stimulus; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042093 T-helper cell differentiation; GO:0042110 T cell activation; GO:0042127 regulation of cell population proliferation; GO:0042133 neurotransmitter metabolic process; GO:0042221 response to chemical; GO:0042303 molting cycle; GO:0042325 regulation of phosphorylation; GO:0042335 cuticle development; GO:0042414 epinephrine metabolic process; GO:0042415 norepinephrine metabolic process; GO:0042417 dopamine metabolic process; GO:0042421 norepinephrine biosynthetic process; GO:0042423 catecholamine biosynthetic process; GO:0042428 serotonin metabolic process; GO:0042430 indole-containing compound metabolic process; GO:0042592 homeostatic process; GO:0042633 hair cycle; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043062 extracellular structure organization; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043200 response to amino acid; GO:0043269 regulation of ion transport; GO:0043271 negative regulation of ion transport; GO:0043367 CD4-positive"," alpha-beta T cell differentiation; GO:0043412 macromolecule modification; GO:0043436 oxoacid metabolic process; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043473 pigmentation; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043588 skin development; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044106 cellular amine metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0045321 leukocyte activation; GO:0045793 positive regulation of cell size; GO:0046034 ATP metabolic process; GO:0046189 phenol-containing compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046631 alpha-beta T cell activation; GO:0046632 alpha-beta T cell differentiation; GO:0046649 lymphocyte activation; GO:0046677 response to antibiotic; GO:0046686 response to cadmium ion; GO:0046688 response to copper ion; GO:0046903 secretion; GO:0046916 cellular transition metal ion homeostasis; GO:0048066 developmental pigmentation; GO:0048067 cuticle pigmentation; GO:0048085 adult chitin-containing cuticle pigmentation; GO:0048251 elastic fiber assembly; GO:0048286 lung alveolus development; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048730 epidermis morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048771 tissue remodeling; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050678 regulation of epithelial cell proliferation; GO:0050679 positive regulation of epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051208 sequestering of calcium ion; GO:0051216 cartilage development; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051341 regulation of oxidoreductase activity; GO:0051353 positive regulation of oxidoreductase activity; GO:0051541 elastin metabolic process; GO:0051542 elastin biosynthetic process; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055070 copper ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060003 copper ion export; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0061008 hepaticobiliary system development; GO:0061448 connective tissue development; GO:0061687 detoxification of inorganic compound; GO:0062012 regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070482 response to oxygen levels; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071230 cellular response to amino acid stimulus; GO:0071236 cellular response to antibiotic; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071276 cellular response to cadmium ion; GO:0071279 cellular response to cobalt ion; GO:0071280 cellular response to copper ion; GO:0071281 cellular response to iron ion; GO:0071284 cellular response to lead ion; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071450 cellular response to oxygen radical; GO:0071451 cellular response to superoxide; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0072521 purine-containing compound metabolic process; GO:0072593 reactive oxygen species metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0085029 extracellular matrix assembly; GO:0090066 regulation of anatomical structure size; GO:0097164 ammonium ion metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097237 cellular response to toxic substance; GO:0097435 supramolecular fiber organization; GO:0097501 stress response to metal ion; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098754 detoxification; GO:0098771 inorganic ion homeostasis; GO:0098773 skin epidermis development; GO:0098869 cellular oxidant detoxification; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900542 regulation of purine nucleotide metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901160 primary amino compound metabolic process; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902743 regulation of lamellipodium organization; GO:1902745 positive regulation of lamellipodium organization; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903578 regulation of ATP metabolic process; GO:1904062 regulation of cation transmembrane transport; GO:1904063 negative regulation of cation transmembrane transport; GO:1904732 regulation of electron transfer activity; GO:1904752 regulation of vascular associated smooth muscle cell migration; GO:1904754 positive regulation of vascular associated smooth muscle cell migration; GO:1904959 regulation of cytochrome-c oxidase activity; GO:1990169 stress response to copper ion; GO:1990748 cellular detoxification; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005902 microvillus; GO:0005903 brush border; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0030140 trans-Golgi network transport vesicle; GO:0030141 secretory granule; GO:0030659 cytoplasmic vesicle membrane; GO:0030666 endocytic vesicle membrane; GO:0030670 phagocytic vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031410 cytoplasmic vesicle; GO:0031526 brush border membrane; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043204 perikaryon; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body; GO:0045121 membrane raft; GO:0045177 apical part of cell; GO:0045335 phagocytic vesicle; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098857 membrane microdomain; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0005375 copper ion transmembrane transporter activity; GO:0005488 binding; GO:0005507 copper ion binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008047 enzyme activator activity; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015662 P-type ion transporter activity; GO:0016462 pyrophosphatase activity; GO:0016530 metallochaperone activity; GO:0016531 copper chaperone activity; GO:0016532 superoxide dismutase copper chaperone activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019829 ATPase-coupled cation transmembrane transporter activity; GO:0019899 enzyme binding; GO:0022804 active transmembrane transporter activity; GO:0022853 active ion transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0030234 enzyme regulator activity; GO:0030554 adenyl nucleotide binding; GO:0031267 small GTPase binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0032767 copper-dependent protein binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042625 ATPase-coupled ion transmembrane transporter activity; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043682 P-type divalent copper transporter activity; GO:0046872 metal ion binding; GO:0046873 metal ion transmembrane transporter activity; GO:0046914 transition metal ion binding; GO:0046915 transition metal ion transmembrane transporter activity; GO:0051020 GTPase binding; GO:0051087 chaperone binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0098772 molecular function regulator; GO:0140104 molecular carrier activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1903136 cuprous ion binding;","PF00403; PF00702","PF00403 Heavy-metal-associated domain; PF00702 haloacid dehalogenase-like hydrolase","P","KOG0207","Cation transport ATPase","WP3286 COPPER HOMEOSTASIS","http://www.wikipathways.org/instance/WP3286_r106367",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-2262752 Cellular responses to stress;R-HSA-3299685 Detoxification of Reactive Oxygen Species;R-HSA-382551 Transport of small molecules;R-HSA-6803157 Antimicrobial peptides;R-HSA-6803544 Ion influx/efflux at host-pathogen interface;R-HSA-8953897 Cellular responses to stimuli;R-HSA-936837 Ion transport by P-type ATPases;R-HSA-9711123 Cellular response to chemical stress;R-HSA-983712 Ion channel transport","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3299685;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-6803157;https://reactome.org/PathwayBrowser/#/R-HSA-6803544;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-936837;https://reactome.org/PathwayBrowser/#/R-HSA-9711123;https://reactome.org/PathwayBrowser/#/R-HSA-983712","HYPOXIA;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["Q05397","Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2","PTK2",0.579269364,1.157003E-3,"down",11907.7,11547.6,11944,6769.98,7643.08,6092.67,1.277992338,1.239344653,1.281888231,0.726587214,0.820292557,0.653895007,"nucleus","K05725","PTK2; focal adhesion kinase 1 [EC:2.7.10.2]","hsa04510 Focal adhesion; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa04360 Axon guidance; hsa05170 Human immunodeficiency virus 1 infection; hsa05200 Pathways in cancer; hsa04935 Growth hormone synthesis"," secretion and action; hsa05418 Fluid shear stress and atherosclerosis; hsa05131 Shigellosis; hsa05165 Human papillomavirus infection; hsa04670 Leukocyte transendothelial migration; hsa05205 Proteoglycans in cancer; hsa04370 VEGF signaling pathway; hsa04012 ErbB signaling pathway; hsa01522 Endocrine resistance; hsa05135 Yersinia infection; hsa04062 Chemokine signaling pathway; hsa05146 Amoebiasis; hsa05202 Transcriptional misregulation in cancer; hsa05222 Small cell lung cancer; hsa05163 Human cytomegalovirus infection; hsa05100 Bacterial invasion of epithelial cells; hsa04810 Regulation of actin cytoskeleton; hsa04151 PI3K-Akt signaling pathway; hsa05417 Lipid and atherosclerosis","GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0000226 microtubule cytoskeleton organization; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001525 angiogenesis; GO:0001558 regulation of cell growth; GO:0001568 blood vessel development; GO:0001570 vasculogenesis; GO:0001667 ameboidal-type cell migration; GO:0001764 neuron migration; GO:0001890 placenta development; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001944 vasculature development; GO:0001952 regulation of cell-matrix adhesion; GO:0001954 positive regulation of cell-matrix adhesion; GO:0002009 morphogenesis of an epithelium; GO:0002011 morphogenesis of an epithelial sheet; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0003006 developmental process involved in reproduction; GO:0003007 heart morphogenesis; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006508 proteolysis; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006873 cellular ion homeostasis; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007097 nuclear migration; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007162 negative regulation of cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007179 transforming growth factor beta receptor signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0008015 blood circulation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008347 glial cell migration; GO:0008360 regulation of cell shape; GO:0008582 regulation of synaptic assembly at neuromuscular junction; GO:0009268 response to pH; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009743 response to carbohydrate; GO:0009746 response to hexose; GO:0009749 response to glucose; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010594 regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010611 regulation of cardiac muscle hypertrophy; GO:0010613 positive regulation of cardiac muscle hypertrophy; GO:0010631 epithelial cell migration; GO:0010632 regulation of epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0014013 regulation of gliogenesis; GO:0014015 positive regulation of gliogenesis; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling; GO:0014070 response to organic cyclic compound; GO:0014742 positive regulation of muscle hypertrophy; GO:0014743 regulation of muscle hypertrophy; GO:0014910 regulation of smooth muscle cell migration; GO:0014911 positive regulation of smooth muscle cell migration; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019216 regulation of lipid metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021795 cerebral cortex cell migration; GO:0021799 cerebral cortex radially oriented cell migration; GO:0021801 cerebral cortex radial glia-guided migration; GO:0021852 pyramidal neuron migration to cerebral cortex; GO:0021859 pyramidal neuron differentiation; GO:0021860 pyramidal neuron development; GO:0021872 forebrain generation of neurons; GO:0021879 forebrain neuron differentiation; GO:0021884 forebrain neuron development; GO:0021885 forebrain cell migration; GO:0021953 central nervous system neuron differentiation; GO:0021954 central nervous system neuron development; GO:0021955 central nervous system neuron axonogenesis; GO:0021987 cerebral cortex development; GO:0022008 neurogenesis; GO:0022029 telencephalon cell migration; GO:0022030 telencephalon glial cell migration; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030002 cellular anion homeostasis; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030162 regulation of proteolysis; GO:0030182 neuron differentiation; GO:0030198 extracellular matrix organization; GO:0030278 regulation of ossification; GO:0030307 positive regulation of cell growth; GO:0030320 cellular monovalent inorganic anion homeostasis; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030644 cellular chloride ion homeostasis; GO:0030900 forebrain development; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031952 regulation of protein autophosphorylation; GO:0031953 negative regulation of protein autophosphorylation; GO:0032092 positive regulation of protein binding; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032355 response to estradiol; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032507 maintenance of protein location in cell; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0033628 regulation of cell adhesion mediated by integrin; GO:0033673 negative regulation of kinase activity; GO:0033674 positive regulation of kinase activity; GO:0033993 response to lipid; GO:0034284 response to monosaccharide; GO:0034613 cellular protein localization; GO:0035150 regulation of tube size; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035296 regulation of tube diameter; GO:0035556 intracellular signal transduction; GO:0035994 response to muscle stretch; GO:0036211 protein modification process; GO:0038007 netrin-activated signaling pathway; GO:0038083 peptidyl-tyrosine autophosphorylation; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0038127 ERBB signaling pathway; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042060 wound healing; GO:0042063 gliogenesis; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043062 extracellular structure organization; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043434 response to peptide hormone; GO:0043502 regulation of muscle adaptation; GO:0043542 endothelial cell migration; GO:0043549 regulation of kinase activity; GO:0043550 regulation of lipid kinase activity; GO:0043551 regulation of phosphatidylinositol 3-kinase activity; GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity; GO:0044057 regulation of system process; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044319 wound healing"," spreading of cells; GO:0045087 innate immune response; GO:0045185 maintenance of protein location; GO:0045444 fat cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045667 regulation of osteoblast differentiation; GO:0045732 positive regulation of protein catabolic process; GO:0045785 positive regulation of cell adhesion; GO:0045807 positive regulation of endocytosis; GO:0045834 positive regulation of lipid metabolic process; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045862 positive regulation of proteolysis; GO:0045886 negative regulation of synaptic assembly at neuromuscular junction; GO:0045926 negative regulation of growth; GO:0045927 positive regulation of growth; GO:0045936 negative regulation of phosphate metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046620 regulation of organ growth; GO:0046621 negative regulation of organ growth; GO:0046685 response to arsenic-containing substance; GO:0046777 protein autophosphorylation; GO:0046907 intracellular transport; GO:0048010 vascular endothelial growth factor receptor signaling pathway; GO:0048013 ephrin receptor signaling pathway; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048878 chemical homeostasis; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050771 negative regulation of axonogenesis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051493 regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051647 nucleus localization; GO:0051649 establishment of localization in cell; GO:0051651 maintenance of location in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051893 regulation of focal adhesion assembly; GO:0051894 positive regulation of focal adhesion assembly; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051964 negative regulation of synapse assembly; GO:0055064 chloride ion homeostasis; GO:0055081 anion homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055083 monovalent inorganic anion homeostasis; GO:0060055 angiogenesis involved in wound healing; GO:0060251 regulation of glial cell proliferation; GO:0060252 positive regulation of glial cell proliferation; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060396 growth hormone receptor signaling pathway; GO:0060416 response to growth hormone; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061098 positive regulation of protein tyrosine kinase activity; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071375 cellular response to peptide hormone stimulus; GO:0071378 cellular response to growth hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090109 regulation of cell-substrate junction assembly; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090218 positive regulation of lipid kinase activity; GO:0090257 regulation of muscle system process; GO:0090504 epiboly; GO:0090505 epiboly involved in wound healing; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0097746 blood vessel diameter maintenance; GO:0098657 import into cell; GO:0098771 inorganic ion homeostasis; GO:0099177 regulation of trans-synaptic signaling; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900024 regulation of substrate adhesion-dependent cell spreading; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901888 regulation of cell junction assembly; GO:1901890 positive regulation of cell junction assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903391 regulation of adherens junction organization; GO:1903393 positive regulation of adherens junction organization; GO:1903725 regulation of phospholipid metabolic process; GO:1903727 positive regulation of phospholipid metabolic process; GO:1904235 regulation of substrate-dependent cell migration"," cell attachment to substrate; GO:1904237 positive regulation of substrate-dependent cell migration"," cell attachment to substrate; GO:1904396 regulation of neuromuscular junction development; GO:1904397 negative regulation of neuromuscular junction development; GO:1905809 negative regulation of synapse organization; GO:2000026 regulation of multicellular organismal development; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000209 regulation of anoikis; GO:2000811 negative regulation of anoikis;","GO:0001725 stress fiber; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0009898 cytoplasmic side of plasma membrane; GO:0014704 intercalated disc; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0016604 nuclear body; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030424 axon; GO:0030425 dendrite; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0031252 cell leading edge; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032432 actin filament bundle; GO:0036477 somatodendritic compartment; GO:0042383 sarcolemma; GO:0042641 actomyosin; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043679 axon terminus; GO:0044291 cell-cell contact zone; GO:0044306 neuron projection terminus; GO:0044309 neuron spine; GO:0045177 apical part of cell; GO:0045202 synapse; GO:0061174 type I terminal bouton; GO:0061176 type Ib terminal bouton; GO:0061177 type Is terminal bouton; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0097517 contractile actin filament bundle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0098794 postsynapse; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0002020 protease binding; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004197 cysteine-type endopeptidase activity; GO:0004198 calcium-dependent cysteine-type endopeptidase activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0004715 non-membrane spanning protein tyrosine kinase activity; GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0008432 JUN kinase binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016787 hydrolase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019902 phosphatase binding; GO:0019904 protein domain specific binding; GO:0031267 small GTPase binding; GO:0031625 ubiquitin protein ligase binding; GO:0042169 SH2 domain binding; GO:0042802 identical protein binding; GO:0043548 phosphatidylinositol 3-kinase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044877 protein-containing complex binding; GO:0050839 cell adhesion molecule binding; GO:0051020 GTPase binding; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF18038; PF00373; PF07714; PF03623","PF18038 FERM N-terminal domain; PF00373 FERM central domain; PF07714 Protein tyrosine and serine/threonine kinase; PF03623 Focal adhesion targeting region","T","KOG4257","Focal adhesion tyrosine kinase FAK"," contains FERM domain","WP244 ALPHA 6 BETA 4 SIGNALING PATHWAY;WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY;WP1539 ANGIOGENESIS;WP2864 APOPTOSISRELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER;WP3929 CHEMOKINE SIGNALING PATHWAY;WP2355 CORTICOTROPINRELEASING HORMONE SIGNALING PATHWAY;WP437 EGFEGFR SIGNALING PATHWAY;WP673 ERBB SIGNALING PATHWAY;WP306 FOCAL ADHESION;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP313 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING;WP4541 HIPPOMERLIN SIGNALING DYSREGULATION;WP185 INTEGRINMEDIATED CELL ADHESION;WP2034 LEPTIN SIGNALING PATHWAY;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP4205 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA;WP4560 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT;WP3301 MFAP5MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS;WP2643 NANOPARTICLEMEDIATED ACTIVATION OF RECEPTOR SIGNALING;WP4747 NETRINUNC5B SIGNALING PATHWAY;WP5144 NRP1TRIGGERED SIGNALING PATHWAYS IN PANCREATIC CANCER;WP3287 OVERVIEW OF NANOPARTICLE EFFECTS;WP3680 PHYSICOCHEMICAL FEATURES AND TOXICITYASSOCIATED PATHWAYS;WP4172 PI3KAKT SIGNALING PATHWAY;WP2572 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS;WP3995 PRION DISEASE PATHWAY;WP2037 PROLACTIN SIGNALING PATHWAY;WP3303 RAC1PAK1P38MMP2 PATHWAY;WP2018 RANKLRANK SIGNALING PATHWAY;WP51 REGULATION OF ACTIN CYTOSKELETON;WP4658 SMALL CELL LUNG CANCER;WP366 TGFBETA SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP244_r120686;http://www.wikipathways.org/instance/WP138_r120688;http://www.wikipathways.org/instance/WP1539_r118358;http://www.wikipathways.org/instance/WP2864_r108133;http://www.wikipathways.org/instance/WP3929_r119247;http://www.wikipathways.org/instance/WP2355_r120664;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP673_r118930;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP3932_r120304;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP313_r118735;http://www.wikipathways.org/instance/WP4541_r116745;http://www.wikipathways.org/instance/WP185_r116785;http://www.wikipathways.org/instance/WP2034_r120670;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP4205_r118937;http://www.wikipathways.org/instance/WP4560_r108134;http://www.wikipathways.org/instance/WP3301_r120029;http://www.wikipathways.org/instance/WP2643_r110709;http://www.wikipathways.org/instance/WP4747_r116543;http://www.wikipathways.org/instance/WP5144_r120537;http://www.wikipathways.org/instance/WP3287_r118405;http://www.wikipathways.org/instance/WP3680_r117651;http://www.wikipathways.org/instance/WP4172_r116400;http://www.wikipathways.org/instance/WP2572_r119251;http://www.wikipathways.org/instance/WP3995_r119304;http://www.wikipathways.org/instance/WP2037_r116779;http://www.wikipathways.org/instance/WP3303_r120561;http://www.wikipathways.org/instance/WP2018_r120672;http://www.wikipathways.org/instance/WP51_r116716;http://www.wikipathways.org/instance/WP4658_r119261;http://www.wikipathways.org/instance/WP366_r120697;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-109581 Apoptosis;R-HSA-109582 Hemostasis;R-HSA-111465 Apoptotic cleavage of cellular proteins;R-HSA-1266738 Developmental Biology;R-HSA-1500931 Cell-Cell communication;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194138 Signaling by VEGF;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-354192 Integrin signaling;R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins ;R-HSA-372708 p130Cas linkage to MAPK signaling for integrins;R-HSA-373752 Netrin-1 signaling;R-HSA-375165 NCAM signaling for neurite out-growth;R-HSA-391160 Signal regulatory protein family interactions;R-HSA-3928662 EPHB-mediated forward signaling;R-HSA-418885 DCC mediated attractive signaling;R-HSA-422475 Axon guidance;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-5357801 Programmed Cell Death;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6806834 Signaling by MET;R-HSA-75153 Apoptotic execution phase;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76009 Platelet Aggregation (Plug Formation);R-HSA-8874081 MET activates PTK2 signaling;R-HSA-8875878 MET promotes cell motility;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9009391 Extra-nuclear estrogen signaling;R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3",null,"ANGIOGENESIS;APICAL JUNCTION;APOPTOSIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANGIOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APOPTOSIS"]
["Q06124","Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3","PTPN11",1.272839848,0.002172225,"up",74051.6,79904.1,72962.4,92495.8,98195.1,98139.5,0.861485007,0.929570517,0.848813714,1.076057032,1.142360278,1.141713451,"cytoplasm","K07293","PTPN11; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]","hsa05120 Epithelial cell signaling in Helicobacter pylori infection; hsa04014 Ras signaling pathway; hsa05208 Chemical carcinogenesis - reactive oxygen species; hsa04360 Axon guidance; hsa05211 Renal cell carcinoma; hsa04650 Natural killer cell mediated cytotoxicity; hsa05168 Herpes simplex virus 1 infection; hsa04670 Leukocyte transendothelial migration; hsa05205 Proteoglycans in cancer; hsa04630 JAK-STAT signaling pathway; hsa04625 C-type lectin receptor signaling pathway; hsa04931 Insulin resistance; hsa04072 Phospholipase D signaling pathway; hsa04722 Neurotrophin signaling pathway; hsa05130 Pathogenic Escherichia coli infection; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa05220 Chronic myeloid leukemia; hsa04920 Adipocytokine signaling pathway","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000578 embryonic axis specification; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001501 skeletal system development; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001752 compound eye photoreceptor fate commitment; GO:0001754 eye photoreceptor cell differentiation; GO:0001763 morphogenesis of a branching structure; GO:0001775 cell activation; GO:0001894 tissue homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006629 lipid metabolic process; GO:0006638 neutral lipid metabolic process; GO:0006639 acylglycerol metabolic process; GO:0006641 triglyceride metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006911 phagocytosis"," engulfment; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007354 zygotic determination of anterior/posterior axis"," embryo; GO:0007362 terminal region determination; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007418 ventral midline development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007427 epithelial cell migration"," open tracheal system; GO:0007428 primary branching"," open tracheal system; GO:0007444 imaginal disc development; GO:0007465 R7 cell fate commitment; GO:0007498 mesoderm development; GO:0007507 heart development; GO:0007548 sex differentiation; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008069 dorsal/ventral axis specification"," ovarian follicular epithelium; GO:0008152 metabolic process; GO:0008293 torso signaling pathway; GO:0008543 fibroblast growth factor receptor signaling pathway; GO:0008595 anterior/posterior axis specification",{"$cut":{"chars":17952,"head":" embryo; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009950 dorsal/ventral axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010033 response to organic substance; GO:0010171 body morphogenesis; GO:0010324 membrane invagination; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0010827 regulation of glucose transmembrane transport; GO:0010828 positive regulation of glucose transmembrane transport; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016311 dephosphorylation; GO:0016333 morphogenesis of follicular epithelium; GO:0016334 establishment or maintenance of polarity of follicular epithelium; GO:0016477 cell migration; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019953 sexual reproduction; GO:0021549 cerebellum development; GO:0021575 hindbrain morphogenesis; GO:0021587 cerebellum morphogenesis; GO:0021695 cerebellar cortex development; GO:0021696 cerebellar cortex morphogenesis; GO:0021697 cerebellar cortex formation; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030168 platelet activation; GO:0030182 neuron differentiation; GO:0030219 megakaryocyte differentiation; GO:0030220 platelet formation; GO:0030258 lipid modification; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0030902 hindbrain development; GO:0031175 neuron projection development; GO:0031294 lymphocyte costimulation; GO:0031295 T cell costimulation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification pro"}},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0001664 G protein-coupled receptor binding; GO:0001784 phosphotyrosine residue binding; GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004725 protein tyrosine phosphatase activity; GO:0004726 non-membrane spanning protein tyrosine phosphatase activity; GO:0005102 signaling receptor binding; GO:0005158 insulin receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016303 1-phosphatidylinositol-3-kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030674 protein-macromolecule adaptor activity; GO:0030971 receptor tyrosine kinase binding; GO:0031748 D1 dopamine receptor binding; GO:0035004 phosphatidylinositol 3-kinase activity; GO:0035591 signaling adaptor activity; GO:0042578 phosphoric ester hydrolase activity; GO:0043274 phospholipase binding; GO:0043560 insulin receptor substrate binding; GO:0044877 protein-containing complex binding; GO:0045309 protein phosphorylated amino acid binding; GO:0046934 phosphatidylinositol-4","5-bisphosphate 3-kinase activity; GO:0050780 dopamine receptor binding; GO:0050839 cell adhesion molecule binding; GO:0051219 phosphoprotein binding; GO:0051427 hormone receptor binding; GO:0051428 peptide hormone receptor binding; GO:0052742 phosphatidylinositol kinase activity; GO:0052813 phosphatidylinositol bisphosphate kinase activity; GO:0060090 molecular adaptor activity; GO:0140096 catalytic activity"," acting on a protein; GO:1990782 protein tyrosine kinase binding;","PF00017; PF00102","PF00017 SH2 domain; PF00102 Protein-tyrosine phosphatase","T","KOG0790","Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes","WP244 ALPHA 6 BETA 4 SIGNALING PATHWAY;WP5036 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY;WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP4582 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE;WP4585 CANCER IMMUNOTHERAPY BY PD1 BLOCKADE;WP437 EGFEGFR SIGNALING PATHWAY;WP3931 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS;WP4549 FRAGILE X SYNDROME;WP4659 GASTRIN SIGNALING PATHWAY;WP1591 HEART DEVELOPMENT;WP3646 HEPATITIS C AND HEPATOCELLULAR CARCINOMA;WP313 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING;WP195 IL1 SIGNALING PATHWAY;WP49 IL2 SIGNALING PATHWAY;WP286 IL3 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP127 IL5 SIGNALING PATHWAY;WP364 IL6 SIGNALING PATHWAY;WP481 INSULIN SIGNALING;WP585 INTERFERON TYPE I SIGNALING PATHWAYS;WP2332 INTERLEUKIN11 SIGNALING PATHWAY;WP5074 KALLMANN SYNDROME;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP2034 LEPTIN SIGNALING PATHWAY;WP4205 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA;WP4747 NETRINUNC5B SIGNALING PATHWAY;WP2374 ONCOSTATIN M SIGNALING PATHWAY;WP2526 PDGF PATHWAY;WP2253 PILOCYTIC ASTROCYTOMA;WP2037 PROLACTIN SIGNALING PATHWAY;WP3303 RAC1PAK1P38MMP2 PATHWAY;WP4223 RAS SIGNALING;WP69 TCELL RECEPTOR TCR SIGNALING PATHWAY;WP2203 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING PATHWAY;WP619 TYPE II INTERFERON SIGNALING IFNG;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP244_r120686;http://www.wikipathways.org/instance/WP5036_r119016;http://www.wikipathways.org/instance/WP23_r120701;http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP4582_r108125;http://www.wikipathways.org/instance/WP4585_r108119;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP3931_r117717;http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP1591_r118366;http://www.wikipathways.org/instance/WP3646_r116732;http://www.wikipathways.org/instance/WP313_r118735;http://www.wikipathways.org/instance/WP195_r120702;http://www.wikipathways.org/instance/WP49_r120703;http://www.wikipathways.org/instance/WP286_r120663;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP127_r120669;http://www.wikipathways.org/instance/WP364_r120715;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP585_r107188;http://www.wikipathways.org/instance/WP2332_r120725;http://www.wikipathways.org/instance/WP5074_r120388;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP2034_r120670;http://www.wikipathways.org/instance/WP4205_r118937;http://www.wikipathways.org/instance/WP4747_r116543;http://www.wikipathways.org/instance/WP2374_r120781;http://www.wikipathways.org/instance/WP2526_r117815;http://www.wikipathways.org/instance/WP2253_r112071;http://www.wikipathways.org/instance/WP2037_r116779;http://www.wikipathways.org/instance/WP3303_r120561;http://www.wikipathways.org/instance/WP4223_r119284;http://www.wikipathways.org/instance/WP69_r120700;http://www.wikipathways.org/instance/WP2203_r120724;http://www.wikipathways.org/instance/WP619_r106442;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1059683 Interleukin-6 signaling;R-HSA-109582 Hemostasis;R-HSA-109704 PI3K Cascade;R-HSA-110056 MAPK3 (ERK1) activation;R-HSA-112399 IRS-mediated signalling;R-HSA-112409 RAF-independent MAPK1/3 activation;R-HSA-112411 MAPK1 (ERK2) activation;R-HSA-114604 GPVI-mediated activation cascade;R-HSA-1170546 Prolactin receptor signaling;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1266738 Developmental Biology;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1295596 Spry regulation of FGF signaling;R-HSA-1433557 Signaling by SCF-KIT;R-HSA-1500931 Cell-Cell communication;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-166520 Signaling by NTRKs;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-177929 Signaling by EGFR;R-HSA-180292 GAB1 signalosome;R-HSA-186763 Downstream signal transduction;R-HSA-186797 Signaling by PDGF;R-HSA-190236 Signaling by FGFR;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-210990 PECAM1 interactions;R-HSA-210993 Tie2 Signaling;R-HSA-212436 Generic Transcription Pathway;R-HSA-2219528 PI3K/AKT Signaling in Cancer;R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer;R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R);R-HSA-2428924 IGF1R signaling cascade;R-HSA-2428928 IRS-related events triggered by IGF1R;R-HSA-2586552 Signaling by Leptin;R-HSA-373752 Netrin-1 signaling;R-HSA-388841 Costimulation by the CD28 family;R-HSA-389513 CTLA4 inhibitory signaling;R-HSA-389948 PD-1 signaling;R-HSA-391160 Signal regulatory protein family interactions;R-HSA-418346 Platelet homeostasis;R-HSA-418886 Netrin mediated repulsion signals;R-HSA-422475 Axon guidance;R-HSA-432142 Platelet sensitization by LDL;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-512988 Interleukin-3"," Interleukin-5 and GM-CSF signaling;R-HSA-5654687 Downstream signaling of activated FGFR1;R-HSA-5654689 PI-3K cascade:FGFR1;R-HSA-5654693 FRS-mediated FGFR1 signaling;R-HSA-5654695 PI-3K cascade:FGFR2;R-HSA-5654696 Downstream signaling of activated FGFR2;R-HSA-5654700 FRS-mediated FGFR2 signaling;R-HSA-5654706 FRS-mediated FGFR3 signaling;R-HSA-5654708 Downstream signaling of activated FGFR3;R-HSA-5654710 PI-3K cascade:FGFR3;R-HSA-5654712 FRS-mediated FGFR4 signaling;R-HSA-5654716 Downstream signaling of activated FGFR4;R-HSA-5654720 PI-3K cascade:FGFR4;R-HSA-5654726 Negative regulation of FGFR1 signaling;R-HSA-5654727 Negative regulation of FGFR2 signaling;R-HSA-5654732 Negative regulation of FGFR3 signaling;R-HSA-5654733 Negative regulation of FGFR4 signaling;R-HSA-5654736 Signaling by FGFR1;R-HSA-5654738 Signaling by FGFR2;R-HSA-5654741 Signaling by FGFR3;R-HSA-5654743 Signaling by FGFR4;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5663205 Infectious disease;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6783589 Interleukin-6 family signaling;R-HSA-6806834 Signaling by MET;R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-74751 Insulin receptor signalling cascade;R-HSA-74752 Signaling by Insulin receptor;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-877300 Interferon gamma signaling;R-HSA-877312 Regulation of IFNG signaling;R-HSA-8853659 RET signaling;R-HSA-8854691 Interleukin-20 family signaling;R-HSA-8865999 MET activates PTPN11;R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8934593 Regulation of RUNX1 Expression and Activity;R-HSA-9006115 Signaling by NTRK2 (TRKB);R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9008059 Interleukin-37 signaling;R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3;R-HSA-909733 Interferon alpha/beta signaling;R-HSA-912694 Regulation of IFNA/IFNB signaling;R-HSA-913531 Interferon Signaling;R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-9607240 FLT3 Signaling;R-HSA-9645135 STAT5 Activation;R-HSA-9674555 Signaling by CSF3 (G-CSF);R-HSA-9675108 Nervous system development;R-HSA-9679506 SARS-CoV Infections;R-HSA-9682385 FLT3 signaling in disease;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants;R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions",null,"IL6 JAK STAT3 SIGNALING;PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL6_JAK_STAT3_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["Q07666","KH domain-containing"," RNA-binding"," signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1","KHDRBS1",1.114917391,0.014378462,"nochange",72314.6,73634.8,77505.9,84591,84151.5,80391.7,0.918106729,0.934867999,0.984015515,1.073968,1.068388104,1.020653654,"cytoplasm","K13198",null,null,"GO:0000003 reproduction; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008380 RNA splicing; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032239 regulation of nucleobase-containing compound transport; GO:0032241 positive regulation of nucleobase-containing compound transport; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044839 cell cycle G2/M phase transition; GO:0045727 positive regulation of translation; GO:0045786 negative regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045948 positive regulation of translational initiation; GO:0046483 heterocycle metabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046831 regulation of RNA export from nucleus; GO:0046833 positive regulation of RNA export from nucleus; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048232 male gamete generation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903047 mitotic cell cycle process; GO:1903311 regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070618 Grb2-Sos complex; GO:0071944 cell periphery; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008143 poly(A) binding; GO:0008187 poly-pyrimidine tract binding; GO:0008266 poly(U) RNA binding; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding; GO:0030674 protein-macromolecule adaptor activity; GO:0035591 signaling adaptor activity; GO:0042802 identical protein binding; GO:0044877 protein-containing complex binding; GO:0060090 molecular adaptor activity; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF16274; PF00013; PF16568","PF16274 Qua1 domain; PF00013 KH domain; PF16568 Tyrosine-rich domain of Sam68","A","KOG1588","RNA-binding protein Sam68 and related KH domain proteins","WP2034 LEPTIN SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2034_r120670","Transcription factor","R-HSA-162582 Signal Transduction;R-HSA-8848021 Signaling by PTK6;R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing;R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-8848021;https://reactome.org/PathwayBrowser/#/R-HSA-8849468;https://reactome.org/PathwayBrowser/#/R-HSA-9006927"]
["Q08380","Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1","LGALS3BP",1.224225809,0.033786824,"nochange",21725.6,20915.9,25458.6,26487.5,28301.7,28580.7,0.860590216,0.828516538,1.008461081,1.049217667,1.121081402,1.132133096,"extracellular","K17300",null,null,"GO:0002576 platelet degranulation; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006968 cellular defense response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0023052 signaling; GO:0032940 secretion by cell; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0098657 import into cell;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031089 platelet dense granule lumen; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0042827 platelet dense granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0005044 scavenger receptor activity; GO:0038024 cargo receptor activity;","PF00530; PF07707","PF00530 Scavenger receptor cysteine-rich domain; PF07707 BTB And C-terminal Kelch",{"$nulls":3},"WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP5115_r120597",null,"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005","INTERFERON ALPHA RESPONSE;INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_ALPHA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["Q08945","FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1","SSRP1",1.043784104,0.025199312,"nochange",110460,110667,113515,117290,117557,114447,0.969038039,0.970853998,0.995838792,1.028955926,1.03129825,1.004014996,"nucleus","K09272",null,null,"GO:0000003 reproduction; GO:0001672 regulation of chromatin assembly or disassembly; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0030154 cell differentiation; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032774 RNA biosynthetic process; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051098 regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0110053 regulation of actin filament organization; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1902275 regulation of chromatin organization; GO:1902531 regulation of intracellular signal transduction; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0008023 transcription elongation factor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035101 FACT complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0031490 chromatin DNA binding; GO:0031491 nucleosome binding; GO:0031492 nucleosomal DNA binding; GO:0043621 protein self-association; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF17292; PF03531; PF08512; PF00505","PF17292 POB3-like N-terminal PH domain; PF03531 Structure-specific recognition protein (SSRP1); PF08512 Histone chaperone Rttp106-like; PF00505 HMG (high mobility group) box","KLB","KOG0526","Nucleosome-binding factor SPN"," POB3 subunit",null,null,"Transcription factor","R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation;R-HSA-167243 Tat-mediated HIV elongation arrest and recovery;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-167287 HIV elongation arrest and recovery;R-HSA-167290 Pausing and recovery of HIV elongation;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-5633007 Regulation of TP53 Activity;R-HSA-5663205 Infectious disease;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75955 RNA Polymerase II Transcription Elongation","https://reactome.org/PathwayBrowser/#/R-HSA-112382;https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-167152;https://reactome.org/PathwayBrowser/#/R-HSA-167169;https://reactome.org/PathwayBrowser/#/R-HSA-167172;https://reactome.org/PathwayBrowser/#/R-HSA-167200;https://reactome.org/PathwayBrowser/#/R-HSA-167238;https://reactome.org/PathwayBrowser/#/R-HSA-167243;https://reactome.org/PathwayBrowser/#/R-HSA-167246;https://reactome.org/PathwayBrowser/#/R-HSA-167287;https://reactome.org/PathwayBrowser/#/R-HSA-167290;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-5633007;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-674695;https://reactome.org/PathwayBrowser/#/R-HSA-6796648;https://reactome.org/PathwayBrowser/#/R-HSA-6804756;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75955","DNA REPAIR;E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["Q0VG06","Fanconi anemia core complex-associated protein 100 OS=Homo sapiens OX=9606 GN=FAAP100 PE=1 SV=3","FAAP100",0.610764864,0.338289794,"nochange",3976.24,3591.37,4636.26,3275.03,1694.1,"NA",1.157701042,1.045644325,1.34986898,0.953540441,0.493245211,"NA","extracellular","K10993","FAAP100; fanconi anemia core complex 100 kDa subunit","hsa03460 Fanconi anemia pathway","GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036297 interstrand cross-link repair; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045111 intermediate filament cytoskeleton; GO:0070013 intracellular organelle lumen;",{"$nulls":6},"WP4946 DNA REPAIR PATHWAYS FULL NETWORK","http://www.wikipathways.org/instance/WP4946_r117703",null,"R-HSA-6783310 Fanconi Anemia Pathway;R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-6783310;https://reactome.org/PathwayBrowser/#/R-HSA-73894"]
["Q12792","Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3","TWF1",1.34246035,0.003939112,"up",9569.79,10124.9,8749.8,12093.7,13005.8,13086.1,0.861753901,0.911741227,0.787914289,1.089030497,1.171164559,1.178395527,"cytoplasm","K08870",null,null,"GO:0000003 reproduction; GO:0001667 ameboidal-type cell migration; GO:0001932 regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007274 neuromuscular synaptic transmission; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008154 actin polymerization or depolymerization; GO:0008407 chaeta morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010591 regulation of lamellipodium assembly; GO:0010611 regulation of cardiac muscle hypertrophy; GO:0010613 positive regulation of cardiac muscle hypertrophy; GO:0010631 epithelial cell migration; GO:0010639 negative regulation of organelle organization; GO:0014742 positive regulation of muscle hypertrophy; GO:0014743 regulation of muscle hypertrophy; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016319 mushroom body development; GO:0016477 cell migration; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030042 actin filament depolymerization; GO:0030154 cell differentiation; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030834 regulation of actin filament depolymerization; GO:0030835 negative regulation of actin filament depolymerization; GO:0030837 negative regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032507 maintenance of protein location in cell; GO:0032535 regulation of cellular component size; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0036465 synaptic vesicle recycling; GO:0040011 locomotion; GO:0042325 regulation of phosphorylation; GO:0042989 sequestering of actin monomers; GO:0043170 macromolecule metabolic process; GO:0043242 negative regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043502 regulation of muscle adaptation; GO:0043538 regulation of actin phosphorylation; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045185 maintenance of protein location; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048488 synaptic vesicle endocytosis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051016 barbed-end actin filament capping; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051261 protein depolymerization; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051651 maintenance of location in cell; GO:0051674 localization of cell; GO:0051693 actin filament capping; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090257 regulation of muscle system process; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901564 organonitrogen compound metabolic process; GO:1901879 regulation of protein depolymerization; GO:1901880 negative regulation of protein depolymerization; GO:1902743 regulation of lamellipodium organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030016 myofibril; GO:0030054 cell junction; GO:0030175 filopodium; GO:0042995 cell projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0098858 actin-based cell projection; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0003779 actin binding; GO:0003785 actin monomer binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004713 protein tyrosine kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035091 phosphatidylinositol binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00241","PF00241 Cofilin/tropomyosin-type actin-binding protein","W","KOG1747","Protein tyrosine kinase 9/actin monomer-binding protein",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013418 RHOBTB2 GTPase cycle;R-HSA-9659379 Sensory processing of sound;R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea;R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea;R-HSA-9706574 RHOBTB GTPase Cycle;R-HSA-9709957 Sensory Perception;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013418;https://reactome.org/PathwayBrowser/#/R-HSA-9659379;https://reactome.org/PathwayBrowser/#/R-HSA-9662360;https://reactome.org/PathwayBrowser/#/R-HSA-9662361;https://reactome.org/PathwayBrowser/#/R-HSA-9706574;https://reactome.org/PathwayBrowser/#/R-HSA-9709957;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q12874","Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1","SF3A3",0.994339505,0.869699865,"nochange",44997.6,43821.3,46999.6,42851.1,45013.4,47185.2,0.996741589,0.970685374,1.04108788,0.949194479,0.997091574,1.045199104,"cytoplasm","K12827","SF3A3; splicing factor 3A subunit 3","hsa03040 Spliceosome","GO:0000003 reproduction; GO:0000245 spliceosomal complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000389 mRNA 3'-splice site recognition; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006376 mRNA splice site selection; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009566 fertilization; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0046483 heterocycle metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005686 U2 snRNP; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071013 catalytic step 2 spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF12108; PF16837; PF13297","PF12108 Splicing factor SF3a60 binding domain; PF16837 Pre-mRNA-splicing factor SF3A3"," of SF3a complex"," Prp9; PF13297 Replication stress response SDE2 C-terminal","A","KOG2636","Splicing factor 3a"," subunit 3","WP410 EXERCISEINDUCED CIRCADIAN REGULATION;WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP410_r117108;http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["Q12979","Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2","ABR",0.823033179,0.399447581,"nochange",11998.5,7577.84,9304.78,5465.84,9091.06,9213.22,1.367318225,0.863551172,1.060348816,0.62287308,1.035993834,1.049914874,"cytoplasm","K20629",null,null,"GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0008361 regulation of cell size; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016043 cellular component organization; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0032535 regulation of cellular component size; GO:0035023 regulation of Rho protein signal transduction; GO:0035025 positive regulation of Rho protein signal transduction; GO:0035556 intracellular signal transduction; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0045792 negative regulation of cell size; GO:0046578 regulation of Ras protein signal transduction; GO:0046579 positive regulation of Ras protein signal transduction; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051057 positive regulation of small GTPase mediated signal transduction; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016020 membrane;","GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00621; PF00169; PF00168; PF00620","PF00621 RhoGEF domain; PF00169 PH domain; PF00168 C2 domain; PF00620 RhoGAP domain","T","KOG4269","Rac GTPase-activating protein BCR/ABR",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-193648 NRAGE signals death through JNK;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-194315 Signaling by Rho GTPases;R-HSA-204998 Cell death signalling via NRAGE"," NRIF and NADE;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-416482 G alpha (12/13) signalling events;R-HSA-73887 Death Receptor Signalling;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013026 RHOB GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-193648;https://reactome.org/PathwayBrowser/#/R-HSA-193704;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-204998;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-416482;https://reactome.org/PathwayBrowser/#/R-HSA-73887;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013026;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q12996","Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1","CSTF3",0.830333601,0.010855974,"nochange",43453,45754.2,44371.4,36990.9,39444.5,34479.4,1.066360074,1.122832764,1.088898105,0.907776652,0.96798932,0.846143086,"cytoplasm","K14408","CSTF3; cleavage stimulation factor subunit 3","hsa03015 mRNA surveillance pathway","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006353 DNA-templated transcription"," termination; GO:0006366 transcription by RNA polymerase II; GO:0006369 termination of RNA polymerase II transcription; GO:0006378 mRNA polyadenylation; GO:0006379 mRNA cleavage; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043631 RNA polyadenylation; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0051341 regulation of oxidoreductase activity; GO:0051353 positive regulation of oxidoreductase activity; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903218 regulation of malate dehydrogenase (decarboxylating) (NADP+) activity; GO:1903220 positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005848 mRNA cleavage stimulating factor complex; GO:0005849 mRNA cleavage factor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG1914","mRNA cleavage and polyadenylation factor I complex"," subunit RNA14","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75067 Processing of Capped Intronless Pre-mRNA;R-HSA-77595 Processing of Intronless Pre-mRNAs;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75067;https://reactome.org/PathwayBrowser/#/R-HSA-77595;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["Q13111","Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3","CHAF1A",0.803338409,0.018053892,"nochange",13107.4,14436,14620.4,11160,10473.4,12238.4,1.034310244,1.139150608,1.153701687,0.880640121,0.826460237,0.965737102,"nucleus","K10750",null,null,"GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006334 nucleosome assembly; GO:0006335 DNA replication-dependent chromatin assembly; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007444 imaginal disc development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010212 response to ionizing radiation; GO:0010332 response to gamma radiation; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0031497 chromatin assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034723 DNA replication-dependent chromatin organization; GO:0034728 nucleosome organization; GO:0035264 multicellular organism growth; GO:0035295 tube development; GO:0040007 growth; GO:0042023 DNA endoreduplication; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044786 cell cycle DNA replication; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048589 developmental growth; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0060429 epithelium development; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901576 organic substance biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033186 CAF-1 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003682 chromatin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019904 protein domain specific binding; GO:0042802 identical protein binding; GO:0051082 unfolded protein binding; GO:0070087 chromo shadow domain binding;","PF15557; PF15539","PF15557 CAF1 complex subunit p150"," region binding to PCNA; PF15539 CAF1 complex subunit p150"," region binding to CAF1-p60 at C-term","B","KOG4364","Chromatin assembly factor-I","WP2509 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH","http://www.wikipathways.org/instance/WP2509_r101755","Transcription factor",null,null,"G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["Q13136","Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1","PPFIA1",0.997107024,0.937219098,"nochange",12499.9,11510.6,12180.6,12384.3,11433.9,12268.2,1.037659023,0.95553388,1.011152848,1.028062675,0.949166753,1.018424821,"nucleus",{"$nulls":3},"GO:0001505 regulation of neurotransmitter levels; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0009987 cellular process; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023061 signal release; GO:0031589 cell-substrate adhesion; GO:0032231 regulation of actin filament bundle assembly; GO:0032232 negative regulation of actin filament bundle assembly; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0044087 regulation of cellular component biogenesis; GO:0046903 secretion; GO:0048167 regulation of synaptic plasticity; GO:0048168 regulation of neuronal synaptic plasticity; GO:0048172 regulation of short-term neuronal synaptic plasticity; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051497 negative regulation of stress fiber assembly; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0098916 anterograde trans-synaptic signaling; GO:0099177 regulation of trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1903076 regulation of protein localization to plasma membrane; GO:1903077 negative regulation of protein localization to plasma membrane; GO:1903828 negative regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904376 negative regulation of protein localization to cell periphery; GO:1905475 regulation of protein localization to membrane; GO:1905476 negative regulation of protein localization to membrane;","GO:0001669 acrosomal vesicle; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0012505 endomembrane system; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0045202 synapse; GO:0048786 presynaptic active zone; GO:0070161 anchoring junction; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0098875 epididymosome; GO:0099503 secretory vesicle; GO:1903561 extracellular vesicle; GO:1990742 microvesicle;",null,"PF00536; PF07647","PF00536 SAM domain (Sterile alpha motif); PF07647 SAM domain (Sterile alpha motif)","R","KOG0249","LAR-interacting protein and related proteins",{"$nulls":3},"R-HSA-112310 Neurotransmitter release cycle;R-HSA-112315 Transmission across Chemical Synapses;R-HSA-112316 Neuronal System;R-HSA-181429 Serotonin Neurotransmitter Release Cycle;R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle;R-HSA-210500 Glutamate Neurotransmitter Release Cycle;R-HSA-212676 Dopamine Neurotransmitter Release Cycle;R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle;R-HSA-388844 Receptor-type tyrosine-protein phosphatases;R-HSA-6794362 Protein-protein interactions at synapses","https://reactome.org/PathwayBrowser/#/R-HSA-112310;https://reactome.org/PathwayBrowser/#/R-HSA-112315;https://reactome.org/PathwayBrowser/#/R-HSA-112316;https://reactome.org/PathwayBrowser/#/R-HSA-181429;https://reactome.org/PathwayBrowser/#/R-HSA-181430;https://reactome.org/PathwayBrowser/#/R-HSA-210500;https://reactome.org/PathwayBrowser/#/R-HSA-212676;https://reactome.org/PathwayBrowser/#/R-HSA-264642;https://reactome.org/PathwayBrowser/#/R-HSA-388844;https://reactome.org/PathwayBrowser/#/R-HSA-6794362"]
["Q13243","Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1","SRSF5",0.853011997,0.016216281,"nochange",93620.6,96600.7,85411.4,79469.3,76185.9,79462.8,1.099799961,1.13480843,1.003363089,0.933558779,0.89498732,0.933482421,"nucleus","K12893","SRSF4_5_6; serine/arginine-rich splicing factor 4/5/6","hsa05168 Herpes simplex virus 1 infection; hsa03040 Spliceosome","GO:0000075 cell cycle checkpoint signaling; GO:0000245 spliceosomal complex assembly; GO:0000278 mitotic cell cycle; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter; GO:0001889 liver development; GO:0002252 immune effector process; GO:0002376 immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006376 mRNA splice site selection; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009611 response to wounding; GO:0009615 response to virus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010948 negative regulation of cell cycle process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031099 regeneration; GO:0031100 animal organ regeneration; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031440 regulation of mRNA 3'-end processing; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0033036 macromolecule localization; GO:0033120 positive regulation of RNA splicing; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043254 regulation of protein-containing complex assembly; GO:0043434 response to peptide hormone; GO:0043484 regulation of RNA splicing; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045184 establishment of protein localization; GO:0045786 negative regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051128 regulation of cellular component organization; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051607 defense response to virus; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060260 regulation of transcription initiation from RNA polymerase II promoter; GO:0061008 hepaticobiliary system development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071166 ribonucleoprotein complex localization; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097421 liver regeneration; GO:0098542 defense response to other organism; GO:1901360 organic cyclic compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903311 regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2000142 regulation of DNA-templated transcription"," initiation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0043422 protein kinase B binding; GO:0050733 RS domain binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","A","KOG0106","Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q13263","Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5","TRIM28",1.268749234,1.06232E-4,"up",546506,555399,571830,699985,719127,704438,0.863521174,0.877572792,0.903535026,1.106029703,1.136275523,1.113065783,"nucleus","K08882",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001701 in utero embryonic development; GO:0001837 epithelial to mesenchymal transition; GO:0001890 placenta development; GO:0001892 embryonic placenta development; GO:0002009 morphogenesis of an epithelium; GO:0002376 immune system process; GO:0003006 developmental process involved in reproduction; GO:0003401 axis elongation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006282 regulation of DNA repair; GO:0006304 DNA modification; GO:0006305 DNA alkylation; GO:0006306 DNA methylation; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007275 multicellular organism development; GO:0007565 female pregnancy; GO:0007566 embryo implantation; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016310 phosphorylation; GO:0016567 protein ubiquitination; GO:0016925 protein sumoylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032259 methylation; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033157 regulation of intracellular protein transport; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040007 growth; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0043009 chordate embryonic development; GO:0043045 DNA methylation involved in embryo development; GO:0043170 macromolecule metabolic process; GO:0043388 positive regulation of DNA binding; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0044728 DNA methylation or demethylation; GO:0045069 regulation of viral genome replication; GO:0045071 negative regulation of viral genome replication; GO:0045087 innate immune response; GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate; GO:0045739 positive regulation of DNA repair; GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046777 protein autophosphorylation; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048568 embryonic organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048762 mesenchymal cell differentiation; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050792 regulation of viral process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051716 cellular response to stimulus; GO:0060026 convergent extension; GO:0060028 convergent extension involved in axis elongation; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060485 mesenchyme development; GO:0060560 developmental growth involved in morphogenesis; GO:0060669 embryonic placenta morphogenesis; GO:0061458 reproductive system development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly; GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly; GO:0090316 positive regulation of intracellular protein transport; GO:0097659 nucleic acid-templated transcription; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901535 regulation of DNA demethylation; GO:1901536 negative regulation of DNA demethylation; GO:1901538 changes to DNA methylation involved in embryo development; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903829 positive regulation of protein localization; GO:1903900 regulation of viral life cycle; GO:1903901 negative regulation of viral life cycle; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904951 positive regulation of establishment of protein localization; GO:1905269 positive regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000653 regulation of genetic imprinting; GO:2001020 regulation of response to DNA damage stimulus; GO:2001022 positive regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000791 euchromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031625 ubiquitin protein ligase binding; GO:0035851 Krueppel-associated box domain binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0070087 chromo shadow domain binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990841 promoter-specific chromatin binding;","PF14634; PF00643; PF00628","PF14634 zinc-RING finger domain; PF00643 B-box zinc finger; PF00628 PHD-finger","O","KOG2177","Predicted E3 ubiquitin ligase","WP3878 ATM SIGNALING IN DEVELOPMENT AND DISEASE;WP2355 CORTICOTROPINRELEASING HORMONE SIGNALING PATHWAY;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR;WP3959 DNA IRDOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM;WP2857 MESODERMAL COMMITMENT PATHWAY;WP4538 REGULATORY CIRCUITS OF THE STAT3 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3878_r117656;http://www.wikipathways.org/instance/WP2355_r120664;http://www.wikipathways.org/instance/WP4016_r120667;http://www.wikipathways.org/instance/WP3959_r118468;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP4538_r104390","Transcription factor","R-HSA-1643685 Disease;R-HSA-212436 Generic Transcription Pathway;R-HSA-2990846 SUMOylation;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3899300 SUMOylation of transcription cofactors;R-HSA-392499 Metabolism of proteins;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-3899300;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-9609646;https://reactome.org/PathwayBrowser/#/R-HSA-9609690","MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["Q13405","39S ribosomal protein L49"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1","MRPL49",0.932671104,0.371061811,"nochange",34400.5,42699.5,38036.3,36614.9,34330,36439.4,0.927568054,1.151340595,1.025603023,0.987276684,0.925667107,0.982544537,"mitochondria","K17430",null,null,"GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000315 organellar large ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005762 mitochondrial large ribosomal subunit; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;","PF05046","PF05046 Mitochondrial large subunit ribosomal protein (Img2)","S","KOG4034","Uncharacterized conserved protein NOF (Neighbor of FAU)",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q13451","Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2","FKBP5",0.885561216,0.012196561,"nochange",131359,140798,142781,119972,124178,123303,1.007365882,1.079751684,1.094958914,0.920041258,0.95229623,0.945586031,"cytoplasm","K09571","FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]","hsa04915 Estrogen signaling pathway","GO:0000413 protein peptidyl-prolyl isomerization; GO:0003008 system process; GO:0006457 protein folding; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007422 peripheral nervous system development; GO:0007600 sensory perception; GO:0007601 visual perception; GO:0008152 metabolic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009584 detection of visible light; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0010639 negative regulation of organelle organization; GO:0010721 negative regulation of cell development; GO:0010959 regulation of metal ion transport; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0018193 peptidyl-amino acid modification; GO:0018208 peptidyl-proline modification; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0031110 regulation of microtubule polymerization or depolymerization; GO:0031111 negative regulation of microtubule polymerization or depolymerization; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0033043 regulation of organelle organization; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043269 regulation of ion transport; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050906 detection of stimulus involved in sensory perception; GO:0050908 detection of light stimulus involved in visual perception; GO:0050953 sensory perception of light stimulus; GO:0050962 detection of light stimulus involved in sensory perception; GO:0051049 regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051606 detection of stimulus; GO:0051707 response to other organism; GO:0051924 regulation of calcium ion transport; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060284 regulation of cell development; GO:0061077 chaperone-mediated protein folding; GO:0065007 biological regulation; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0071704 organic substance metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900034 regulation of cellular response to heat; GO:1901564 organonitrogen compound metabolic process; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016027 inaD signaling complex; GO:0016028 rhabdomere; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044295 axonal growth cone; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003755 peptidyl-prolyl cis-trans isomerase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005527 macrolide binding; GO:0005528 FK506 binding; GO:0016853 isomerase activity; GO:0016859 cis-trans isomerase activity; GO:0030674 protein-macromolecule adaptor activity; GO:0031072 heat shock protein binding; GO:0051879 Hsp90 protein binding; GO:0060090 molecular adaptor activity; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901363 heterocyclic compound binding;","PF00254","PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase","O","KOG0543","FKBP-type peptidyl-prolyl cis-trans isomerase","WP2879 FARNESOID X RECEPTOR PATHWAY;WP3584 MECP2 AND ASSOCIATED RETT SYNDROME;WP2882 NUCLEAR RECEPTORS METAPATHWAY","http://www.wikipathways.org/instance/WP2879_r116462;http://www.wikipathways.org/instance/WP3584_r117155;http://www.wikipathways.org/instance/WP2882_r117808",null,"R-HSA-162582 Signal Transduction;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8939211 ESR-mediated signaling;R-HSA-8953897 Cellular responses to stimuli;R-HSA-8986944 Transcriptional Regulation by MECP2;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9022699 MECP2 regulates neuronal receptors and channels","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3371497;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-8986944;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9022699","ANDROGEN RESPONSE;ESTROGEN RESPONSE EARLY;ESTROGEN RESPONSE LATE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE"]
["Q13496","Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2","MTM1",0.520452558,0.000208604,"down",10250.5,10423.1,11578.6,5824.23,5728.76,5232.75,1.254192162,1.275310504,1.416690832,0.71261925,0.70093809,0.640249162,"cytoplasm","K01108","MTM1; myotubularin [EC:3.1.3.64 3.1.3.95]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0000278 mitotic cell cycle; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007010 cytoskeleton organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0008152 metabolic process; GO:0008333 endosome to lysosome transport; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016202 regulation of striated muscle tissue development; GO:0016241 regulation of macroautophagy; GO:0016242 negative regulation of macroautophagy; GO:0016311 dephosphorylation; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0019725 cellular homeostasis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030162 regulation of proteolysis; GO:0030258 lipid modification; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032006 regulation of TOR signaling; GO:0032007 negative regulation of TOR signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032456 endocytic recycling; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044088 regulation of vacuole organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045103 intermediate filament-based process; GO:0045104 intermediate filament cytoskeleton organization; GO:0045109 intermediate filament organization; GO:0045806 negative regulation of endocytosis; GO:0045844 positive regulation of striated muscle tissue development; GO:0045861 negative regulation of proteolysis; GO:0045927 positive regulation of growth; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046716 muscle cell cellular homeostasis; GO:0046839 phospholipid dephosphorylation; GO:0046856 phosphatidylinositol dephosphorylation; GO:0046907 intracellular transport; GO:0048311 mitochondrion distribution; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048631 regulation of skeletal muscle tissue growth; GO:0048633 positive regulation of skeletal muscle tissue growth; GO:0048634 regulation of muscle organ development; GO:0048636 positive regulation of muscle organ development; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048641 regulation of skeletal muscle tissue development; GO:0048643 positive regulation of skeletal muscle tissue development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050764 regulation of phagocytosis; GO:0050765 negative regulation of phagocytosis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051649 establishment of localization in cell; GO:0051896 regulation of protein kinase B signaling; GO:0051898 negative regulation of protein kinase B signaling; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060101 negative regulation of phagocytosis"," engulfment; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060627 regulation of vesicle-mediated transport; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070584 mitochondrion morphogenesis; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097435 supramolecular fiber organization; GO:1901074 regulation of engulfment of apoptotic cell; GO:1901075 negative regulation of engulfment of apoptotic cell; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1901861 regulation of muscle tissue development; GO:1901863 positive regulation of muscle tissue development; GO:1902115 regulation of organelle assembly; GO:1902116 negative regulation of organelle assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902902 negative regulation of autophagosome assembly; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1905153 regulation of membrane invagination; GO:1905154 negative regulation of membrane invagination; GO:2000026 regulation of multicellular organismal development; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2000425 regulation of apoptotic cell clearance; GO:2000426 negative regulation of apoptotic cell clearance; GO:2000785 regulation of autophagosome assembly;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005770 late endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030175 filopodium; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031674 I band; GO:0031982 vesicle; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0045177 apical part of cell; GO:0045179 apical cortex; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098858 actin-based cell projection; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004438 phosphatidylinositol-3-phosphatase activity; GO:0004721 phosphoprotein phosphatase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008138 protein tyrosine/serine/threonine phosphatase activity; GO:0008289 lipid binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0019215 intermediate filament binding; GO:0034593 phosphatidylinositol bisphosphate phosphatase activity; GO:0035091 phosphatidylinositol binding; GO:0042578 phosphoric ester hydrolase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0052629 phosphatidylinositol-3","5-bisphosphate 3-phosphatase activity; GO:0052744 phosphatidylinositol monophosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity; GO:0106018 phosphatidylinositol-3","5-bisphosphate phosphatase activity; GO:0140096 catalytic activity"," acting on a protein; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF02893; PF06602","PF02893 GRAM domain; PF06602 Myotubularin-like phosphatase domain","IU","KOG4471","Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1","WP4971 PHOSPHOINOSITIDES METABOLISM","http://www.wikipathways.org/instance/WP4971_r112223",null,"R-HSA-1430728 Metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-1660516 Synthesis of PIPs at the early endosome membrane;R-HSA-1660517 Synthesis of PIPs at the late endosome membrane;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-1660516;https://reactome.org/PathwayBrowser/#/R-HSA-1660517;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["Q13561","Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4","DCTN2",1.010693773,0.691936365,"nochange",71634.6,67582.1,68025.4,68799,68452.4,72206.9,1.031454733,0.973103458,0.979486461,0.990625399,0.985634763,1.039695186,"cytoplasm","K10424","DCTN2; dynactin 2","hsa05132 Salmonella infection; hsa05016 Huntington disease; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa04962 Vasopressin-regulated water reabsorption; hsa05014 Amyotrophic lateral sclerosis","GO:0000003 reproduction; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000132 establishment of mitotic spindle orientation; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000578 embryonic axis specification; GO:0001654 eye development; GO:0001754 eye photoreceptor cell differentiation; GO:0001894 tissue homeostasis; GO:0001895 retina homeostasis; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002376 immune system process; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006403 RNA localization; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007028 cytoplasm organization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007059 chromosome segregation; GO:0007097 nuclear migration; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007296 vitellogenesis; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007316 pole plasm RNA localization; GO:0007338 single fertilization; GO:0007346 regulation of mitotic cell cycle; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007602 phototransduction; GO:0008088 axo-dendritic transport; GO:0008090 retrograde axonal transport; GO:0008104 protein localization; GO:0008283 cell population proliferation; GO:0008298 intracellular mRNA localization; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008544 epidermis development; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009566 fertilization; GO:0009581 detection of external stimulus; GO:0009582 detection of abiotic stimulus; GO:0009583 detection of light stimulus; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009913 epidermal cell differentiation; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010001 glial cell differentiation; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010564 regulation of cell cycle process; GO:0010970 transport along microtubule; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016325 oocyte microtubule cytoskeleton organization; GO:0019094 pole plasm mRNA localization; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022406 membrane docking; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030010 establishment of cell polarity; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0030719 P granule organization; GO:0030855 epithelial cell differentiation; GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity; GO:0030952 establishment or maintenance of cytoskeleton polarity; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032400 melanosome localization; GO:0032401 establishment of melanosome localization; GO:0032402 melanosome transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0033036 macromolecule localization; GO:0033059 cellular pigmentation; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0035046 pronuclear migration; GO:0035047 centrosomal and pronuclear rotation; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035282 segmentation; GO:0035315 hair cell differentiation; GO:0040001 establishment of mitotic spindle localization; GO:0042063 gliogenesis; GO:0042490 mechanoreceptor differentiation; GO:0042491 inner ear auditory receptor cell differentiation; GO:0042592 homeostatic process; GO:0043473 pigmentation; GO:0043583 ear development; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044380 protein localization to cytoskeleton; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044782 cilium organization; GO:0044839 cell cycle G2/M phase transition; GO:0045451 pole plasm oskar mRNA localization; GO:0045494 photoreceptor cell maintenance; GO:0046530 photoreceptor cell differentiation; GO:0046907 intracellular transport; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048193 Golgi vesicle transport; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048592 eye morphogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051606 detection of stimulus; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051647 nucleus localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051875 pigment granule localization; GO:0051904 pigment granule transport; GO:0051905 establishment of pigment granule localization; GO:0060113 inner ear receptor cell differentiation; GO:0060117 auditory receptor cell development; GO:0060119 inner ear receptor cell development; GO:0060249 anatomical structure homeostasis; GO:0060271 cilium assembly; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060563 neuroepithelial cell differentiation; GO:0060632 regulation of microtubule-based movement; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061842 microtubule organizing center localization; GO:0061883 clathrin-dependent endocytosis involved in vitellogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071539 protein localization to centrosome; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072583 clathrin-dependent endocytosis; GO:0072698 protein localization to microtubule cytoskeleton; GO:0090596 sensory organ morphogenesis; GO:0097711 ciliary basal body-plasma membrane docking; GO:0098657 import into cell; GO:0098930 axonal transport; GO:0099111 microtubule-based transport; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0140056 organelle localization by membrane tethering; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1905508 protein localization to microtubule organizing center; GO:2001017 regulation of retrograde axon cargo transport; GO:2001019 positive regulation of retrograde axon cargo transport;","GO:0000242 pericentriolar material; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005869 dynactin complex; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005876 spindle microtubule; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0098687 chromosomal region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030507 spectrin binding; GO:0042802 identical protein binding;",null,null,"Z","KOG3958","Putative dynamitin","WP5085 VASOPRESSINREGULATED WATER REABSORPTION","http://www.wikipathways.org/instance/WP5085_r119785",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-1640170 Cell Cycle;R-HSA-168256 Immune System;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-2132295 MHC class II antigen presentation;R-HSA-2262752 Cellular responses to stress;R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition;R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand;R-HSA-380259 Loss of Nlp from mitotic centrosomes;R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes;R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome;R-HSA-380287 Centrosome maturation;R-HSA-380320 Recruitment of NuMA to mitotic centrosomes;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-5617833 Cilium Assembly;R-HSA-5620912 Anchoring of the basal body to the plasma membrane;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-68877 Mitotic Prometaphase;R-HSA-68886 M Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-8854518 AURKA Activation by TPX2;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-8953897 Cellular responses to stimuli;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2132295;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2565942;https://reactome.org/PathwayBrowser/#/R-HSA-3371497;https://reactome.org/PathwayBrowser/#/R-HSA-380259;https://reactome.org/PathwayBrowser/#/R-HSA-380270;https://reactome.org/PathwayBrowser/#/R-HSA-380284;https://reactome.org/PathwayBrowser/#/R-HSA-380287;https://reactome.org/PathwayBrowser/#/R-HSA-380320;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-453274;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620912;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811436;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69275;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-8854518;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["Q13569","G/T mismatch-specific thymine DNA glycosylase OS=Homo sapiens OX=9606 GN=TDG PE=1 SV=2","TDG",2.072314435,0.007913846,"up",5039.09,4129.26,3094.9,7849.73,8181.75,9381.83,0.802476128,0.657585512,0.492863467,1.250071132,1.302945386,1.494058375,"nucleus","K20813","TDG; thymine-DNA glycosylase [EC:3.2.2.29]","hsa03410 Base excision repair","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006139 nucleobase-containing compound metabolic process; GO:0006220 pyrimidine nucleotide metabolic process; GO:0006244 pyrimidine nucleotide catabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006284 base-excision repair; GO:0006285 base-excision repair"," AP site formation; GO:0006298 mismatch repair; GO:0006304 DNA modification; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009166 nucleotide catabolic process; GO:0009219 pyrimidine deoxyribonucleotide metabolic process; GO:0009223 pyrimidine deoxyribonucleotide catabolic process; GO:0009262 deoxyribonucleotide metabolic process; GO:0009264 deoxyribonucleotide catabolic process; GO:0009394 2'-deoxyribonucleotide metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019692 deoxyribose phosphate metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032091 negative regulation of protein binding; GO:0033554 cellular response to stress; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035510 DNA dealkylation; GO:0035511 oxidative DNA demethylation; GO:0035561 regulation of chromatin binding; GO:0035562 negative regulation of chromatin binding; GO:0040029 regulation of gene expression"," epigenetic; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0044728 DNA methylation or demethylation; GO:0045008 depyrimidination; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045995 regulation of embryonic development; GO:0046386 deoxyribose phosphate catabolic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070988 demethylation; GO:0070989 oxidative demethylation; GO:0071704 organic substance metabolic process; GO:0072527 pyrimidine-containing compound metabolic process; GO:0072529 pyrimidine-containing compound catabolic process; GO:0080090 regulation of primary metabolic process; GO:0080111 DNA demethylation; GO:0090304 nucleic acid metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1902544 regulation of DNA N-glycosylase activity; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0000166 nucleotide binding; GO:0000287 magnesium ion binding; GO:0000700 mismatch base pair DNA N-glycosylase activity; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003824 catalytic activity; GO:0004844 uracil DNA N-glycosylase activity; GO:0005080 protein kinase C binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008134 transcription factor binding; GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0016799 hydrolase activity"," hydrolyzing N-glycosyl compounds; GO:0017076 purine nucleotide binding; GO:0019104 DNA N-glycosylase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030554 adenyl nucleotide binding; GO:0030983 mismatched DNA binding; GO:0031402 sodium ion binding; GO:0031404 chloride ion binding; GO:0031420 alkali metal ion binding; GO:0032182 ubiquitin-like protein binding; GO:0032183 SUMO binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043621 protein self-association; GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity; GO:0046872 metal ion binding; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0097506 deaminated base DNA N-glycosylase activity; GO:0140097 catalytic activity"," acting on DNA; GO:0140110 transcription regulator activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF03167","PF03167 Uracil DNA glycosylase superfamily","L","KOG4120","G/T mismatch-specific thymine DNA glycosylase","WP4752 BASE EXCISION REPAIR;WP3585 CYTOSINE METHYLATION;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP1601 FLUOROPYRIMIDINE ACTIVITY","http://www.wikipathways.org/instance/WP4752_r119239;http://www.wikipathways.org/instance/WP3585_r106742;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP1601_r120496",null,"R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine;R-HSA-110329 Cleavage of the damaged pyrimidine ;R-HSA-110357 Displacement of DNA glycosylase by APEX1;R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-392499 Metabolism of proteins;R-HSA-5221030 TET1",2,"3 and TDG demethylate DNA;R-HSA-597592 Post-translational protein modification;R-HSA-73884 Base Excision Repair;R-HSA-73894 DNA Repair;R-HSA-73928 Depyrimidination;R-HSA-73929 Base-Excision Repair"," AP Site Formation;R-HSA-73933 Resolution of Abasic Sites (AP sites);R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-110328;https://reactome.org/PathwayBrowser/#/R-HSA-110329;https://reactome.org/PathwayBrowser/#/R-HSA-110357;https://reactome.org/PathwayBrowser/#/R-HSA-212165;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108214;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5221030;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73884;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-73928;https://reactome.org/PathwayBrowser/#/R-HSA-73929;https://reactome.org/PathwayBrowser/#/R-HSA-73933;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["Q13620","Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4","CUL4B",1.337090529,0.000841715,"up",29914.9,30281.5,30616,40794.7,42486.8,38142.9,0.845703478,0.856067374,0.865523792,1.15327879,1.201114981,1.078311584,"nucleus","K10609","CUL4; cullin 4","hsa05170 Human immunodeficiency virus 1 infection; hsa03420 Nucleotide excision repair; hsa04120 Ubiquitin mediated proteolysis","GO:0000003 reproduction; GO:0000082 G1/S transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0000715 nucleotide-excision repair"," DNA damage recognition; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006277 DNA amplification; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006293 nucleotide-excision repair"," preincision complex stabilization; GO:0006294 nucleotide-excision repair"," preincision complex assembly; GO:0006296 nucleotide-excision repair"," DNA incision"," 5'-to lesion; GO:0006325 chromatin organization; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006513 protein monoubiquitination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007307 eggshell chorion gene amplification; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010390 histone monoubiquitination; GO:0010498 proteasomal protein catabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010927 cellular component assembly involved in morphogenesis; GO:0016043 cellular component organization; GO:0016567 protein ubiquitination; GO:0016570 histone modification; GO:0016574 histone ubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0033522 histone H2A ubiquitination; GO:0033554 cellular response to stress; GO:0033683 nucleotide-excision repair"," DNA incision; GO:0034641 cellular nitrogen compound metabolic process; GO:0034644 cellular response to UV; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035518 histone H2A monoubiquitination; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044843 cell cycle G1/S phase transition; GO:0045732 positive regulation of protein catabolic process; GO:0045787 positive regulation of cell cycle; GO:0045931 positive regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0070911 global genome nucleotide-excision repair; GO:0070914 UV-damage excision repair; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0104004 cellular response to environmental stimulus; GO:0120036 plasma membrane bounded cell projection organization; GO:1900087 positive regulation of G1/S transition of mitotic cell cycle; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901992 positive regulation of mitotic cell cycle phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902808 positive regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:2000045 regulation of G1/S transition of mitotic cell cycle;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031465 Cul4B-RING E3 ubiquitin ligase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0080008 Cul4-RING E3 ubiquitin ligase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding;","PF10557","PF10557 Cullin protein neddylation domain","D","KOG2167","Cullins","WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP2853 ENDODERM DIFFERENTIATION;WP2857 MESODERMAL COMMITMENT PATHWAY;WP4753 NUCLEOTIDE EXCISION REPAIR;WP5114 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM","http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP2853_r116557;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP4753_r119238;http://www.wikipathways.org/instance/WP5114_r119169",null,"R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex;R-HSA-392499 Metabolism of proteins;R-HSA-5696394 DNA Damage Recognition in GG-NER;R-HSA-5696395 Formation of Incision Complex in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-5696400 Dual Incision in GG-NER;R-HSA-597592 Post-translational protein modification;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-73893 DNA Damage Bypass;R-HSA-73894 DNA Repair;R-HSA-8951664 Neddylation","https://reactome.org/PathwayBrowser/#/R-HSA-110314;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5696394;https://reactome.org/PathwayBrowser/#/R-HSA-5696395;https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-5696399;https://reactome.org/PathwayBrowser/#/R-HSA-5696400;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6781823;https://reactome.org/PathwayBrowser/#/R-HSA-6781827;https://reactome.org/PathwayBrowser/#/R-HSA-6782135;https://reactome.org/PathwayBrowser/#/R-HSA-6782210;https://reactome.org/PathwayBrowser/#/R-HSA-73893;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-8951664"]
["Q13825","Methylglutaconyl-CoA hydratase"," mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1","AUH",1.042898167,0.554537363,"nochange",13751.1,14474.5,12307.6,13368.1,13527.4,15376.5,0.996393946,1.048810944,0.891799066,0.968642066,0.980184819,1.114169158,"mitochondria","K05607","AUH; methylglutaconyl-CoA hydratase [EC:4.2.1.18]","hsa00280 Valine"," leucine and isoleucine degradation; hsa01100 Metabolic pathways","GO:0000288 nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009062 fatty acid catabolic process; GO:0009063 cellular amino acid catabolic process; GO:0009081 branched-chain amino acid metabolic process; GO:0009083 branched-chain amino acid catabolic process; GO:0009266 response to temperature stimulus; GO:0009409 response to cold; GO:0009628 response to abiotic stimulus; GO:0009631 cold acclimation; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016042 lipid catabolic process; GO:0016054 organic acid catabolic process; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019395 fatty acid oxidation; GO:0019439 aromatic compound catabolic process; GO:0019752 carboxylic acid metabolic process; GO:0030258 lipid modification; GO:0032787 monocarboxylic acid metabolic process; GO:0034440 lipid oxidation; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0072329 monocarboxylic acid catabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0003824 catalytic activity; GO:0004300 enoyl-CoA hydratase activity; GO:0004490 methylglutaconyl-CoA hydratase activity; GO:0005488 binding; GO:0016829 lyase activity; GO:0016835 carbon-oxygen lyase activity; GO:0016836 hydro-lyase activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00378","PF00378 Enoyl-CoA hydratase/isomerase","I","KOG1679","Enoyl-CoA hydratase","WP3925 AMINO ACID METABOLISM","http://www.wikipathways.org/instance/WP3925_r117062",null,"R-HSA-1430728 Metabolism;R-HSA-70895 Branched-chain amino acid catabolism;R-HSA-71291 Metabolism of amino acids and derivatives","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70895;https://reactome.org/PathwayBrowser/#/R-HSA-71291","FATTY ACID METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM"]
["Q13889","General transcription factor IIH subunit 3 OS=Homo sapiens OX=9606 GN=GTF2H3 PE=1 SV=2","GTF2H3",0.516299572,0.022657566,"nochange",6633.47,8885.36,7572.88,2915.08,5236.42,3770.74,1.136713224,1.522597707,1.297690778,0.499528902,0.897314356,0.646155032,"cytoplasm","nucleus","K03143","TFIIH3; transcription initiation factor TFIIH subunit 3","hsa03022 Basal transcription factors; hsa05203 Viral carcinogenesis; hsa03420 Nucleotide excision repair","GO:0001109 promoter clearance during DNA-templated transcription; GO:0001111 promoter clearance from RNA polymerase II promoter; GO:0001112 DNA-templated transcription open complex formation; GO:0001113 transcription open complex formation at RNA polymerase II promoter; GO:0001120 protein-DNA complex remodeling; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006293 nucleotide-excision repair"," preincision complex stabilization; GO:0006294 nucleotide-excision repair"," preincision complex assembly; GO:0006296 nucleotide-excision repair"," DNA incision"," 5'-to lesion; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006353 DNA-templated transcription"," termination; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006360 transcription by RNA polymerase I; GO:0006361 transcription initiation from RNA polymerase I promoter; GO:0006363 termination of RNA polymerase I transcription; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006370 7-methylguanosine mRNA capping; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006412 translation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006518 peptide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009452 7-methylguanosine RNA capping; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032774 RNA biosynthetic process; GO:0033554 cellular response to stress; GO:0033683 nucleotide-excision repair"," DNA incision; GO:0034367 protein-containing complex remodeling; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0036260 RNA capping; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0070816 phosphorylation of RNA polymerase II C-terminal domain; GO:0070911 global genome nucleotide-excision repair; GO:0071704 organic substance metabolic process; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0000438 core TFIIH complex portion of holo TFIIH complex; GO:0000439 transcription factor TFIIH core complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005669 transcription factor TFIID complex; GO:0005675 transcription factor TFIIH holo complex; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032806 carboxy-terminal domain protein kinase complex; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex; GO:0097550 transcription preinitiation complex; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008135 translation factor activity"," RNA binding; GO:0047485 protein N-terminus binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF03850","PF03850 Transcription factor Tfb4","KL","KOG2487","RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH"," subunit TFB4","WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP405 EUKARYOTIC TRANSCRIPTION INITIATION;WP4753 NUCLEOTIDE EXCISION REPAIR;WP5114 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM","http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP405_r118377;http://www.wikipathways.org/instance/WP4753_r119238;http://www.wikipathways.org/instance/WP5114_r119169",null,"R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-113418 Formation of the Early Elongation Complex;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat;R-HSA-167158 Formation of the HIV-1 Early Elongation Complex;R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection;R-HSA-167161 HIV Transcription Initiation;R-HSA-167162 RNA Polymerase II HIV Promoter Escape;R-HSA-167169 HIV Transcription Elongation;R-HSA-167172 Transcription of the HIV genome;R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat;R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript;R-HSA-212165 Epigenetic regulation of gene expression;R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-427413 NoRC negatively regulates rRNA expression;R-HSA-5250941 Negative epigenetic regulation of rRNA expression;R-HSA-5663205 Infectious disease;R-HSA-5696395 Formation of Incision Complex in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-5696400 Dual Incision in GG-NER;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-6782135 Dual incision in TC-NER;R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-72086 mRNA Capping;R-HSA-73762 RNA Polymerase I Transcription Initiation;R-HSA-73772 RNA Polymerase I Promoter Escape;R-HSA-73776 RNA Polymerase II Promoter Escape;R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening;R-HSA-73854 RNA Polymerase I Promoter Clearance;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73863 RNA Polymerase I Transcription Termination;R-HSA-73864 RNA Polymerase I Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription);R-HSA-75953 RNA Polymerase II Transcription Initiation;R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance;R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE;R-HSA-8953854 Metabolism of RNA",null,"DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["Q14139","Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2","UBE4A",0.704767291,0.00025526,"down",28209.1,27504.9,26328.4,18527.2,19827.2,19466.4,1.210143912,1.179934393,1.129463647,0.79479949,0.85056827,0.835090288,"plasma membrane","K10596","UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]","hsa04120 Ubiquitin mediated proteolysis","GO:0000209 protein polyubiquitination; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0032446 protein modification by small protein conjugation; GO:0033554 cellular response to stress; GO:0034976 response to endoplasmic reticulum stress; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0042221 response to chemical; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0050896 response to stimulus; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0034450 ubiquitin-ubiquitin ligase activity; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF04564","PF04564 U-box domain","O","KOG2042","Ubiquitin fusion degradation protein-2",{"$nulls":3},"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["Q14161","ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2","GIT2",0.942545317,0.332357664,"nochange",12810.6,12643.2,12534.4,11629.6,10939.1,13236.9,1.041599701,1.027988801,1.01914253,0.945575374,0.889432446,1.076261149,"nucleus","K12487","GIT2; G protein-coupled receptor kinase interactor 2","hsa04144 Endocytosis; hsa05135 Yersinia infection","GO:0000003 reproduction; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007525 somatic muscle development; GO:0007548 sex differentiation; GO:0007610 behavior; GO:0008104 protein localization; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008406 gonad development; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016319 mushroom body development; GO:0016477 cell migration; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0032465 regulation of cytokinesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033555 multicellular organismal response to stress; GO:0035262 gonad morphogenesis; GO:0035330 regulation of hippo signaling; GO:0035332 positive regulation of hippo signaling; GO:0035418 protein localization to synapse; GO:0036465 synaptic vesicle recycling; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040039 inductive cell migration; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0045137 development of primary sexual characteristics; GO:0046620 regulation of organ growth; GO:0048013 ephrin receptor signaling pathway; GO:0048265 response to pain; GO:0048266 behavioral response to pain; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048638 regulation of developmental growth; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051302 regulation of cell division; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060322 head development; GO:0061061 muscle structure development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0099504 synaptic vesicle cycle; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1905383 protein localization to presynapse;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030056 hemidesmosome; GO:0031252 cell leading edge; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0048786 presynaptic active zone; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0098793 presynapse;","GO:0005096 GTPase activator activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0044877 protein-containing complex binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF01412; PF12205","PF01412 Putative GTPase activating protein for Arf; PF12205 G protein-coupled receptor kinase-interacting protein 1 C term","T","KOG0818","GTPase-activating proteins of the GIT family","WP185 INTEGRINMEDIATED CELL ADHESION","http://www.wikipathways.org/instance/WP185_r116785",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013409 RHOJ GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9013424 RHOV GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013409;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9013424;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q14204","Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5","DYNC1H1",0.833018047,{"v":2.84272e-05,"d":"2.84E-05"},"down",117597,116498,117755,98606.9,98312.6,96177.9,1.094014799,1.083790709,1.095484686,0.917348298,0.914610401,0.894751107,"cytoplasm","K10413","DYNC1H; dynein cytoplasmic 1 heavy chain","hsa05132 Salmonella infection; hsa04145 Phagosome; hsa04962 Vasopressin-regulated water reabsorption","GO:0000003 reproduction; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001101 response to acid chemical; GO:0001667 ameboidal-type cell migration; GO:0001709 cell fate determination; GO:0001738 morphogenesis of a polarized epithelium; GO:0001775 cell activation; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0002478 antigen processing and presentation of exogenous peptide antigen; GO:0002495 antigen processing and presentation of peptide antigen via MHC class II; GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003341 cilium movement; GO:0006403 RNA localization; GO:0006582 melanin metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007088 regulation of mitotic nuclear division; GO:0007097 nuclear migration; GO:0007098 centrosome cycle; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007277 pole cell development; GO:0007279 pole cell formation; GO:0007281 germ cell development; GO:0007282 cystoblast division; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007294 germarium-derived oocyte fate determination; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007310 oocyte dorsal/ventral axis specification; GO:0007312 oocyte nucleus migration involved in oocyte dorsal/ventral axis specification; GO:0007346 regulation of mitotic cell cycle; GO:0007349 cellularization; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007405 neuroblast proliferation; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008088 axo-dendritic transport; GO:0008089 anterograde axonal transport; GO:0008090 retrograde axonal transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008298 intracellular mRNA localization; GO:0008356 asymmetric cell division; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009798 axis specification; GO:0009888 tissue development; GO:0009950 dorsal/ventral axis specification; GO:0009953 dorsal/ventral pattern formation; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010564 regulation of cell cycle process; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010965 regulation of mitotic sister chromatid separation; GO:0010970 transport along microtubule; GO:0010975 regulation of neuron projection development; GO:0014041 regulation of neuron maturation; GO:0014042 positive regulation of neuron maturation; GO:0014070 response to organic cyclic compound; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016319 mushroom body development; GO:0016322 neuron remodeling; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0016482 cytosolic transport; GO:0018958 phenol-containing compound metabolic process; GO:0019748 secondary metabolic process; GO:0019882 antigen processing and presentation; GO:0019884 antigen processing and presentation of exogenous antigen; GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0019896 axonal transport of mitochondrion; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022406 membrane docking; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023052 signaling; GO:0030010 establishment of cell polarity; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030071 regulation of mitotic metaphase/anaphase transition; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0030706 germarium-derived oocyte differentiation; GO:0030707 ovarian follicle cell development; GO:0030716 oocyte fate determination; GO:0030723 ovarian fusome organization; GO:0030855 epithelial cell differentiation; GO:0030859 polarized epithelial cell differentiation; GO:0031023 microtubule organizing center organization; GO:0031122 cytoplasmic microtubule organization; GO:0031175 neuron projection development; GO:0031344 regulation of cell projection organization; GO:0032252 secretory granule localization; GO:0032253 dense core granule localization; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032886 regulation of microtubule-based process; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033045 regulation of sister chromatid segregation; GO:0033047 regulation of mitotic sister chromatid segregation; GO:0033365 protein localization to organelle; GO:0033962 P-body assembly; GO:0034063 stress granule assembly; GO:0034501 protein localization to kinetochore; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0034643 establishment of mitochondrion localization"," microtubule-mediated; GO:0035006 melanization defense response; GO:0035010 encapsulation of foreign target; GO:0035011 melanotic encapsulation of foreign target; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035089 establishment of apical/basal cell polarity; GO:0036230 granulocyte activation; GO:0040001 establishment of mitotic spindle localization; GO:0040003 chitin-based cuticle development; GO:0040011 locomotion; GO:0042119 neutrophil activation; GO:0042221 response to chemical; GO:0042335 cuticle development; GO:0042440 pigment metabolic process; GO:0042551 neuron maturation; GO:0042886 amide transport; GO:0043200 response to amino acid; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044703 multi-organism reproductive process; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044782 cilium organization; GO:0044839 cell cycle G2/M phase transition; GO:0045055 regulated exocytosis; GO:0045087 innate immune response; GO:0045165 cell fate commitment; GO:0045184 establishment of protein localization; GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity; GO:0045198 establishment of epithelial cell apical/basal polarity; GO:0045321 leukocyte activation; GO:0045478 fusome organization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045787 positive regulation of cell cycle; GO:0045840 positive regulation of mitotic nuclear division; GO:0045931 positive regulation of mitotic cell cycle; GO:0046602 regulation of mitotic centrosome separation; GO:0046604 positive regulation of mitotic centrosome separation; GO:0046605 regulation of centrosome cycle; GO:0046607 positive regulation of centrosome cycle; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0047496 vesicle transport along microtubule; GO:0047497 mitochondrion transport along microtubule; GO:0048002 antigen processing and presentation of peptide antigen; GO:0048134 germ-line cyst formation; GO:0048193 Golgi vesicle transport; GO:0048232 male gamete generation; GO:0048311 mitochondrion distribution; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051236 establishment of RNA localization; GO:0051237 maintenance of RNA location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051295 establishment of meiotic spindle localization; GO:0051296 establishment of meiotic spindle orientation; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051645 Golgi localization; GO:0051646 mitochondrion localization; GO:0051647 nucleus localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051651 maintenance of location in cell; GO:0051653 spindle localization; GO:0051654 establishment of mitochondrion localization; GO:0051656 establishment of organelle localization; GO:0051657 maintenance of organelle location; GO:0051661 maintenance of centrosome location; GO:0051663 oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; GO:0051674 localization of cell; GO:0051683 establishment of Golgi localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051932 synaptic transmission"," GABAergic; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051983 regulation of chromosome segregation; GO:0060236 regulation of mitotic spindle organization; GO:0060271 cilium assembly; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0061162 establishment of monopolar cell polarity; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061339 establishment or maintenance of monopolar cell polarity; GO:0061351 neural precursor cell proliferation; GO:0061842 microtubule organizing center localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071229 cellular response to acid chemical; GO:0071230 cellular response to amino acid stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071459 protein localization to chromosome"," centromeric region; GO:0071495 cellular response to endogenous stimulus; GO:0071695 anatomical structure maturation; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072089 stem cell proliferation; GO:0072382 minus-end-directed vesicle transport along microtubule; GO:0072384 organelle transport along microtubule; GO:0072385 minus-end-directed organelle transport along microtubule; GO:0090068 positive regulation of cell cycle process; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090162 establishment of epithelial cell polarity; GO:0090169 regulation of spindle assembly; GO:0090224 regulation of spindle organization; GO:0090235 regulation of metaphase plate congression; GO:0097066 response to thyroid hormone; GO:0097067 cellular response to thyroid hormone stimulus; GO:0097435 supramolecular fiber organization; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0097711 ciliary basal body-plasma membrane docking; GO:0098916 anterograde trans-synaptic signaling; GO:0098930 axonal transport; GO:0098958 retrograde axonal transport of mitochondrion; GO:0099003 vesicle-mediated transport in synapse; GO:0099111 microtubule-based transport; GO:0099518 vesicle cytoskeletal trafficking; GO:0099519 dense core granule cytoskeletal transport; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140056 organelle localization by membrane tethering; GO:1901360 organic cyclic compound metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901950 dense core granule transport; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902099 regulation of metaphase/anaphase transition of cell cycle; GO:1902115 regulation of organelle assembly; GO:1902117 positive regulation of organelle assembly; GO:1902473 regulation of protein localization to synapse; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903429 regulation of cell maturation; GO:1903431 positive regulation of cell maturation; GO:1903649 regulation of cytoplasmic transport; GO:1903651 positive regulation of cytoplasmic transport; GO:1904799 regulation of neuron remodeling; GO:1904801 positive regulation of neuron remodeling; GO:1904809 regulation of dense core granule transport; GO:1904811 positive regulation of dense core granule transport; GO:1905242 response to 3","3'","5-triiodo-L-thyronine; GO:1905243 cellular response to 3","3'","5-triiodo-L-thyronine; GO:1905818 regulation of chromosome separation; GO:1905832 positive regulation of spindle assembly; GO:1990048 anterograde neuronal dense core vesicle transport; GO:1990089 response to nerve growth factor; GO:1990090 cellular response to nerve growth factor stimulus; GO:2000026 regulation of multicellular organismal development;","GO:0000323 lytic vacuole; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000922 spindle pole; GO:0002177 manchette; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005794 Golgi apparatus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005868 cytoplasmic dynein complex; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0030141 secretory granule; GO:0030175 filopodium; GO:0030286 dynein complex; GO:0030424 axon; GO:0031410 cytoplasmic vesicle; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032838 plasma membrane bounded cell projection cytoplasm; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0036477 somatodendritic compartment; GO:0042582 azurophil granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045169 fusome; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098687 chromosomal region; GO:0098858 actin-based cell projection; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0120111 neuron projection cytoplasm; GO:1902494 catalytic complex; GO:1904115 axon cytoplasm; GO:1990904 ribonucleoprotein complex;","GO:0003774 cytoskeletal motor activity; GO:0003777 microtubule motor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008569 minus-end-directed microtubule motor activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0045503 dynein light chain binding; GO:0045505 dynein intermediate chain binding; GO:0051959 dynein light intermediate chain binding;","PF12774; PF17852; PF12775; PF12780; PF12777; PF12781; PF03028; PF18198; PF18199","PF12774 Hydrolytic ATP binding site of dynein motor region; PF17852 Dynein heavy chain AAA lid domain; PF12775 P-loop containing dynein motor region; PF12780 P-loop containing dynein motor region D4; PF12777 Microtubule-binding stalk of dynein motor; PF12781 ATP-binding dynein motor region; PF03028 Dynein heavy chain region D6 P-loop domain ; PF18198 Dynein heavy chain AAA lid domain; PF18199 Dynein heavy chain C-terminal domain","Z","KOG3595","Dyneins"," heavy chain","WP4352 CILIARY LANDSCAPE;WP4532 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN;WP5085 VASOPRESSINREGULATED WATER REABSORPTION","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP4532_r103287;http://www.wikipathways.org/instance/WP5085_r119785",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-141424 Amplification of signal from the kinetochores;R-HSA-141444 Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal;R-HSA-162582 Signal Transduction;R-HSA-1632852 Macroautophagy;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-2132295 MHC class II antigen presentation;R-HSA-2262752 Cellular responses to stress;R-HSA-2467813 Separation of Sister Chromatids;R-HSA-2500257 Resolution of Sister Chromatid Cohesion;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition;R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand;R-HSA-380259 Loss of Nlp from mitotic centrosomes;R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes;R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome;R-HSA-380287 Centrosome maturation;R-HSA-380320 Recruitment of NuMA to mitotic centrosomes;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-5617833 Cilium Assembly;R-HSA-5620912 Anchoring of the basal body to the plasma membrane;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-5663220 RHO GTPases Activate Formins;R-HSA-597592 Post-translational protein modification;R-HSA-6798695 Neutrophil degranulation;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-68877 Mitotic Prometaphase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69618 Mitotic Spindle Checkpoint;R-HSA-69620 Cell Cycle Checkpoints;R-HSA-8854518 AURKA Activation by TPX2;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-8953897 Cellular responses to stimuli;R-HSA-948021 Transport to the Golgi and subsequent modification;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9612973 Autophagy;R-HSA-9646399 Aggrephagy;R-HSA-9648025 EML4 and NUDC in mitotic spindle formation;R-HSA-9663891 Selective autophagy;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3",null,"MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q14247","Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2","CTTN",0.959995507,0.457128227,"nochange",6389.02,6444.21,6306.37,6132.93,5565.01,6675.99,1.021874508,1.030701723,1.008655277,0.980914886,0.890080459,1.067773147,"cytoplasm","K06106","CTTN; cortactin","hsa05100 Bacterial invasion of epithelial cells; hsa05130 Pathogenic Escherichia coli infection; hsa05205 Proteoglycans in cancer; hsa04530 Tight junction; hsa05131 Shigellosis","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0001558 regulation of cell growth; GO:0001667 ameboidal-type cell migration; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006929 substrate-dependent cell migration; GO:0006930 substrate-dependent cell migration"," cell extension; GO:0006937 regulation of muscle contraction; GO:0006940 regulation of smooth muscle contraction; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007044 cell-substrate junction assembly; GO:0007155 cell adhesion; GO:0007160 cell-matrix adhesion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007300 ovarian nurse cell to oocyte transport; GO:0007301 female germline ring canal formation; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008361 regulation of cell size; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010821 regulation of mitochondrion organization; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030516 regulation of axon extension; GO:0030707 ovarian follicle cell development; GO:0030725 germline ring canal formation; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031532 actin cytoskeleton reorganization; GO:0031589 cell-substrate adhesion; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034332 adherens junction organization; GO:0034333 adherens junction assembly; GO:0034613 cellular protein localization; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043062 extracellular structure organization; GO:0043063 intercellular bridge organization; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043254 regulation of protein-containing complex assembly; GO:0043954 cellular component maintenance; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0045216 cell-cell junction organization; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045807 positive regulation of endocytosis; GO:0045933 positive regulation of muscle contraction; GO:0045987 positive regulation of smooth muscle contraction; GO:0046907 intracellular transport; GO:0048041 focal adhesion assembly; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051960 regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061387 regulation of extent of cell growth; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090257 regulation of muscle system process; GO:0097061 dendritic spine organization; GO:0097062 dendritic spine maintenance; GO:0097581 lamellipodium organization; GO:0098657 import into cell; GO:0098885 modification of postsynaptic actin cytoskeleton; GO:0099010 modification of postsynaptic structure; GO:0099173 postsynapse organization; GO:0099563 modification of synaptic structure; GO:0106027 neuron projection organization; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903146 regulation of autophagy of mitochondrion; GO:2000026 regulation of multicellular organismal development; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001236 regulation of extrinsic apoptotic signaling pathway; GO:2001237 negative regulation of extrinsic apoptotic signaling pathway;","GO:0001726 ruffle; GO:0002102 podosome; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005905 clathrin-coated pit; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030478 actin cap; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0031252 cell leading edge; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045202 synapse; GO:0051233 spindle midzone; GO:0070864 sperm individualization complex; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0098794 postsynapse; GO:0098871 postsynaptic actin cytoskeleton; GO:0099568 cytoplasmic region; GO:0099571 postsynaptic cytoskeleton; GO:0120025 plasma membrane bounded cell projection; GO:1990023 mitotic spindle midzone;","GO:0005488 binding; GO:0005515 protein binding; GO:0005522 profilin binding; GO:0044877 protein-containing complex binding; GO:0070064 proline-rich region binding; GO:0071933 Arp2/3 complex binding;","PF14604","PF14604 Variant SH3 domain",{"$nulls":3},"WP3646 HEPATITIS C AND HEPATOCELLULAR CARCINOMA;WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION","http://www.wikipathways.org/instance/WP3646_r116732;http://www.wikipathways.org/instance/WP2272_r118427",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-199991 Membrane Trafficking;R-HSA-5627123 RHO GTPases activate PAKs;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5627123;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q14498","RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2","RBM39",0.175620902,{"v":9.61165e-09,"d":"9.61E-09"},"down",133532,132991,135030,23593.9,23063.7,23863.5,1.697174236,1.690298197,1.71621362,0.29987538,0.293136607,0.30330196,"nucleus","K13091",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00076; PF15519","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain); PF15519 linker between RRM2 and RRM3 domains in RBM39 protein","K","KOG0147","Transcriptional coactivator CAPER (RRM superfamily)","WP411 MRNA PROCESSING;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP411_r117160;http://www.wikipathways.org/instance/WP3888_r116782","Transcription factor",{"$nulls":4},"RBM39"]
["Q14571","Inositol 1",4,"5-trisphosphate receptor type 2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2","ITPR2",0.731133564,0.000561242,"down",7647.42,7485.34,8025.43,5629.48,5881.66,5420.59,1.144540074,1.120282605,1.201114395,0.842527997,0.880270153,0.811264777,"plasma membrane","K04959","ITPR2; inositol 1",4,"5-triphosphate receptor type 2","hsa04270 Vascular smooth muscle contraction; hsa04935 Growth hormone synthesis"," secretion and action; hsa04371 Apelin signaling pathway; hsa05012 Parkinson disease; hsa04621 NOD-like receptor signaling pathway; hsa04210 Apoptosis; hsa05205 Proteoglycans in cancer; hsa05022 Pathways of neurodegeneration - multiple diseases; hsa04934 Cushing syndrome; hsa04929 GnRH secretion; hsa04971 Gastric acid secretion; hsa04915 Estrogen signaling pathway; hsa04925 Aldosterone synthesis and secretion; hsa04724 Glutamatergic synapse; hsa04928 Parathyroid hormone synthesis"," secretion and action; hsa04020 Calcium signaling pathway; hsa04540 Gap junction; hsa04922 Glucagon signaling pathway; hsa04726 Serotonergic synapse; hsa04218 Cellular senescence; hsa04611 Platelet activation; hsa05020 Prion disease; hsa04728 Dopaminergic synapse; hsa04725 Cholinergic synapse; hsa04972 Pancreatic secretion; hsa05170 Human immunodeficiency virus 1 infection; hsa04921 Oxytocin signaling pathway; hsa04970 Salivary secretion; hsa05010 Alzheimer disease; hsa05131 Shigellosis; hsa04070 Phosphatidylinositol signaling system; hsa04927 Cortisol synthesis and secretion; hsa04720 Long-term potentiation; hsa04625 C-type lectin receptor signaling pathway; hsa05017 Spinocerebellar ataxia; hsa04918 Thyroid hormone synthesis; hsa05163 Human cytomegalovirus infection; hsa04750 Inflammatory mediator regulation of TRP channels; hsa04912 GnRH signaling pathway; hsa04723 Retrograde endocannabinoid signaling; hsa04730 Long-term depression; hsa04924 Renin secretion; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa04022 cGMP-PKG signaling pathway; hsa04114 Oocyte meiosis","GO:0001666 response to hypoxia; GO:0001775 cell activation; GO:0002791 regulation of peptide secretion; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008016 regulation of heart contraction; GO:0008219 cell death; GO:0009611 response to wounding; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009719 response to endogenous stimulus; GO:0009894 regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010243 response to organonitrogen compound; GO:0010506 regulation of autophagy; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0019722 calcium-mediated signaling; GO:0019725 cellular homeostasis; GO:0019932 second-messenger-mediated signaling; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030168 platelet activation; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0032501 multicellular organismal process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033554 cellular response to stress; GO:0034220 ion transmembrane transport; GO:0034976 response to endoplasmic reticulum stress; GO:0035556 intracellular signal transduction; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0043933 protein-containing complex organization; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0045471 response to ethanol; GO:0046677 response to antibiotic; GO:0046683 response to organophosphorus; GO:0046883 regulation of hormone secretion; GO:0048016 inositol phosphate-mediated signaling; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048878 chemical homeostasis; GO:0050708 regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050801 ion homeostasis; GO:0050817 coagulation; GO:0050848 regulation of calcium-mediated signaling; GO:0050849 negative regulation of calcium-mediated signaling; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051209 release of sequestered calcium ion into cytosol; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051282 regulation of sequestering of calcium ion; GO:0051283 negative regulation of sequestering of calcium ion; GO:0051291 protein heterooligomerization; GO:0051480 regulation of cytosolic calcium ion concentration; GO:0051591 response to cAMP; GO:0051592 response to calcium ion; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0060401 cytosolic calcium ion transport; GO:0060402 calcium ion transport into cytosol; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; GO:0070201 regulation of establishment of protein localization; GO:0070482 response to oxygen levels; GO:0070588 calcium ion transmembrane transport; GO:0070887 cellular response to chemical stimulus; GO:0071236 cellular response to antibiotic; GO:0071310 cellular response to organic substance; GO:0071320 cellular response to cAMP; GO:0071361 cellular response to ethanol; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071495 cellular response to endogenous stimulus; GO:0071840 cellular component organization or biogenesis; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097237 cellular response to toxic substance; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0097553 calcium ion transmembrane import into cytosol; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098771 inorganic ion homeostasis; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903522 regulation of blood circulation; GO:1903530 regulation of secretion by cell; GO:1903779 regulation of cardiac conduction;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005640 nuclear outer membrane; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005791 rough endoplasmic reticulum; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005903 brush border; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016528 sarcoplasm; GO:0016529 sarcoplasmic reticulum; GO:0019867 outer membrane; GO:0030141 secretory granule; GO:0030424 axon; GO:0030659 cytoplasmic vesicle membrane; GO:0030667 secretory granule membrane; GO:0031088 platelet dense granule membrane; GO:0031090 organelle membrane; GO:0031094 platelet dense tubular network; GO:0031095 platelet dense tubular network membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0033017 sarcoplasmic reticulum membrane; GO:0036477 somatodendritic compartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042827 platelet dense granule; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043235 receptor complex; GO:0044297 cell body; GO:0045177 apical part of cell; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098827 endoplasmic reticulum subcompartment; GO:0098862 cluster of actin-based cell projections; GO:0099503 secretory vesicle; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0000822 inositol hexakisphosphate binding; GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005217 intracellular ligand-gated ion channel activity; GO:0005220 inositol 1",4,"5-trisphosphate-sensitive calcium-release channel activity; GO:0005246 calcium channel regulator activity; GO:0005261 cation channel activity; GO:0005262 calcium channel activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0008200 ion channel inhibitor activity; GO:0008289 lipid binding; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015085 calcium ion transmembrane transporter activity; GO:0015267 channel activity; GO:0015276 ligand-gated ion channel activity; GO:0015278 calcium-release channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0016247 channel regulator activity; GO:0016248 channel inhibitor activity; GO:0019855 calcium channel inhibitor activity; GO:0022803 passive transmembrane transporter activity; GO:0022834 ligand-gated channel activity; GO:0022836 gated channel activity; GO:0022839 ion gated channel activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0035091 phosphatidylinositol binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043178 alcohol binding; GO:0043533 inositol 1",3,4,"5 tetrakisphosphate binding; GO:0046872 metal ion binding; GO:0046873 metal ion transmembrane transporter activity; GO:0070679 inositol 1",4,"5 trisphosphate binding; GO:0097110 scaffold protein binding; GO:0098772 molecular function regulator; GO:0099094 ligand-gated cation channel activity; GO:0099106 ion channel regulator activity; GO:0099604 ligand-gated calcium channel activity;","PF08709; PF02815","PF08709 Inositol 1",4,"5-trisphosphate/ryanodine receptor; PF02815 MIR domain","T","KOG3533","Inositol 1",4,"5-trisphosphate receptor","WP5124 ALZHEIMERS DISEASE;WP2059 ALZHEIMERS DISEASE AND MIRNA EFFECTS;WP536 CALCIUM REGULATION IN CARDIAC CELLS;WP289 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS;WP4756 RENINANGIOTENSINALDOSTERONE SYSTEM RAAS;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS;WP4698 VITAMIN DSENSITIVE CALCIUM SIGNALING IN DEPRESSION","http://www.wikipathways.org/instance/WP5124_r119432;http://www.wikipathways.org/instance/WP2059_r119468;http://www.wikipathways.org/instance/WP536_r116854;http://www.wikipathways.org/instance/WP289_r120734;http://www.wikipathways.org/instance/WP4756_r120634;http://www.wikipathways.org/instance/WP4746_r120402;http://www.wikipathways.org/instance/WP4698_r119119",null,"R-HSA-109582 Hemostasis;R-HSA-111885 Opioid Signalling;R-HSA-112040 G-protein mediated events;R-HSA-112043 PLC beta mediated events;R-HSA-114508 Effects of PIP2 hydrolysis;R-HSA-1280218 Adaptive Immune System;R-HSA-139853 Elevation of cytosolic Ca2+ levels;R-HSA-1430728 Metabolism;R-HSA-1489509 DAG and IP3 signaling;R-HSA-162582 Signal Transduction;R-HSA-163685 Integration of energy metabolism;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194138 Signaling by VEGF;R-HSA-195721 Signaling by WNT;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029485 Role of phospholipids in phagocytosis;R-HSA-2454202 Fc epsilon receptor (FCERI) signaling;R-HSA-2871809 FCERI mediated Ca+2 mobilization;R-HSA-372790 Signaling by GPCR;R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion;R-HSA-3858494 Beta-catenin independent WNT signaling;R-HSA-388396 GPCR downstream signalling;R-HSA-397014 Muscle contraction;R-HSA-4086398 Ca2+ pathway;R-HSA-416476 G alpha (q) signalling events;R-HSA-418346 Platelet homeostasis;R-HSA-418360 Platelet calcium homeostasis;R-HSA-418594 G alpha (i) signalling events;R-HSA-422356 Regulation of insulin secretion;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-5218921 VEGFR2 mediated cell proliferation;R-HSA-5576891 Cardiac conduction;R-HSA-5578775 Ion homeostasis;R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation;R-HSA-5607764 CLEC7A (Dectin-1) signaling;R-HSA-5621481 C-type lectin receptors (CLRs);R-HSA-5663205 Infectious disease;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9658195 Leishmania infection;R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection;R-HSA-9664323 FCGR3A-mediated IL10 synthesis;R-HSA-9664433 Leishmania parasite growth and survival;R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;R-HSA-983705 Signaling by the B Cell Receptor (BCR)",null,"PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["Q14686","Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3","NCOA6",1.185273743,0.234393355,"nochange",4124.54,6053.96,4254.36,6226.29,5503.09,5377.51,0.78463653,1.151681925,0.809332985,1.184465318,1.046886548,1.022996695,"nucleus","K14971",null,null,"GO:0000003 reproduction; GO:0001541 ovarian follicle development; GO:0001568 blood vessel development; GO:0001701 in utero embryonic development; GO:0001890 placenta development; GO:0001892 embryonic placenta development; GO:0001944 vasculature development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006281 DNA repair; GO:0006310 DNA recombination; GO:0006325 chromatin organization; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0007548 sex differentiation; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008406 gonad development; GO:0008585 female gonad development; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0018022 peptidyl-lysine methylation; GO:0018023 peptidyl-lysine trimethylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030520 intracellular estrogen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031062 positive regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031958 corticosteroid receptor signaling pathway; GO:0032024 positive regulation of insulin secretion; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034968 histone lysine methylation; GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0042921 glucocorticoid receptor signaling pathway; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045137 development of primary sexual characteristics; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046545 development of primary female sexual characteristics; GO:0046660 female sex differentiation; GO:0046883 regulation of hormone secretion; GO:0046887 positive regulation of hormone secretion; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048545 response to steroid hormone; GO:0048568 embryonic organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051568 histone H3-K4 methylation; GO:0051569 regulation of histone H3-K4 methylation; GO:0051571 positive regulation of histone H3-K4 methylation; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060341 regulation of cellular localization; GO:0060674 placenta blood vessel development; GO:0060711 labyrinthine layer development; GO:0060716 labyrinthine layer blood vessel development; GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0080182 histone H3-K4 trimethylation; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090277 positive regulation of peptide hormone secretion; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902275 regulation of chromatin organization; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904951 positive regulation of establishment of protein localization; GO:1905269 positive regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044666 MLL3/4 complex; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003682 chromatin binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016922 nuclear receptor binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0030331 estrogen receptor binding; GO:0030374 nuclear receptor coactivator activity; GO:0035259 glucocorticoid receptor binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0042974 retinoic acid receptor binding; GO:0042975 peroxisome proliferator activated receptor binding; GO:0046965 retinoid X receptor binding; GO:0046966 thyroid hormone receptor binding; GO:0046983 protein dimerization activity; GO:0051427 hormone receptor binding; GO:0140110 transcription regulator activity;",{"$nulls":5},"WP2875 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY;WP2882 NUCLEAR RECEPTORS METAPATHWAY","http://www.wikipathways.org/instance/WP2875_r117690;http://www.wikipathways.org/instance/WP2882_r117808","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-1368082 RORA activates gene expression;R-HSA-1368108 BMAL1:CLOCK","NPAS2 activates circadian gene expression;R-HSA-1430728 Metabolism;R-HSA-1592230 Mitochondrial biogenesis;R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF);R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-1989781 PPARA activates gene expression;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis;R-HSA-2262752 Cellular responses to stress;R-HSA-2426168 Activation of gene expression by SREBF (SREBP);R-HSA-381340 Transcriptional regulation of white adipocyte differentiation;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-400253 Circadian Clock;R-HSA-556833 Metabolism of lipids;R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis;R-HSA-5619507 Activation of HOX genes during differentiation;R-HSA-8953897 Cellular responses to stimuli;R-HSA-8957322 Metabolism of steroids;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9707616 Heme signaling;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1368082;https://reactome.org/PathwayBrowser/#/R-HSA-1368108;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-1655829;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-1989781;https://reactome.org/PathwayBrowser/#/R-HSA-2151201;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2426168;https://reactome.org/PathwayBrowser/#/R-HSA-381340;https://reactome.org/PathwayBrowser/#/R-HSA-400206;https://reactome.org/PathwayBrowser/#/R-HSA-400253;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5617472;https://reactome.org/PathwayBrowser/#/R-HSA-5619507;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-8957322;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9707616;https://reactome.org/PathwayBrowser/#/R-HSA-9711123","APICAL SURFACE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_SURFACE"]
["Q14781","Chromobox protein homolog 2 OS=Homo sapiens OX=9606 GN=CBX2 PE=1 SV=2","CBX2",0.97658693,0.598728859,"nochange",9266.91,8667.5,8304.78,8437.66,8223.34,8963.85,1.072061876,1.002717875,0.960755853,0.976128354,0.951334296,1.037001745,"nucleus","K11451",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007275 multicellular organism development; GO:0007548 sex differentiation; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0045137 development of primary sexual characteristics; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0000152 nuclear ubiquitin ligase complex; GO:0000785 chromatin; GO:0000791 euchromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0031519 PcG protein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035102 PRC1 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003682 chromatin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding;","PF00385","PF00385 Chromo (CHRromatin Organisation MOdifier) domain","B","KOG2748","Uncharacterized conserved protein"," contains chromo domain","WP4842 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT","http://www.wikipathways.org/instance/WP4842_r119114","Transcription factor","R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-212436 Generic Transcription Pathway;R-HSA-2262752 Cellular responses to stress;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559583 Cellular Senescence;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3899300 SUMOylation of transcription cofactors;R-HSA-392499 Metabolism of proteins;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-4570464 SUMOylation of RNA binding proteins;R-HSA-4655427 SUMOylation of DNA methylation proteins;R-HSA-597592 Post-translational protein modification;R-HSA-6807070 PTEN Regulation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known;R-HSA-8943724 Regulation of PTEN gene transcription;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006925 Intracellular signaling by second messengers","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2559580;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108214;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-3899300;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-4551638;https://reactome.org/PathwayBrowser/#/R-HSA-4570464;https://reactome.org/PathwayBrowser/#/R-HSA-4655427;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8939243;https://reactome.org/PathwayBrowser/#/R-HSA-8943724;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9006925"]
["Q14934","Nuclear factor of activated T-cells"," cytoplasmic 4 OS=Homo sapiens OX=9606 GN=NFATC4 PE=1 SV=2","NFATC4",1.399891904,0.128763079,"nochange",1634.16,1616.93,1929.51,1772.95,3023.75,2455.58,0.788631435,0.780316387,0.931164782,0.855610285,1.459235511,1.185041599,"nucleus","K17334","NFATC4; nuclear factor of activated T-cells"," cytoplasmic 4","hsa04921 Oxytocin signaling pathway; hsa05161 Hepatitis B; hsa04360 Axon guidance; hsa05170 Human immunodeficiency virus 1 infection; hsa05166 Human T-cell leukemia virus 1 infection; hsa05163 Human cytomegalovirus infection; hsa04310 Wnt signaling pathway; hsa04218 Cellular senescence; hsa05167 Kaposi sarcoma-associated herpesvirus infection; hsa04625 C-type lectin receptor signaling pathway; hsa04022 cGMP-PKG signaling pathway","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001101 response to acid chemical; GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001569 branching involved in blood vessel morphogenesis; GO:0001763 morphogenesis of a branching structure; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001944 vasculature development; GO:0002009 morphogenesis of an epithelium; GO:0006091 generation of precursor metabolites and energy; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007507 heart development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010226 response to lithium ion; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010771 negative regulation of cell morphogenesis involved in differentiation; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0012501 programmed cell death; GO:0014070 response to organic cyclic compound; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019722 calcium-mediated signaling; GO:0019932 second-messenger-mediated signaling; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030178 negative regulation of Wnt signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0032091 negative regulation of protein binding; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032680 regulation of tumor necrosis factor production; GO:0032760 positive regulation of tumor necrosis factor production; GO:0032774 RNA biosynthetic process; GO:0033173 calcineurin-NFAT signaling cascade; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0034644 cellular response to UV; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0035561 regulation of chromatin binding; GO:0035562 negative regulation of chromatin binding; GO:0042221 response to chemical; GO:0042692 muscle cell differentiation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045333 cellular respiration; GO:0045472 response to ether; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048016 inositol phosphate-mediated signaling; GO:0048167 regulation of synaptic plasticity; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050774 negative regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050804 modulation of chemical synaptic transmission; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051145 smooth muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0055001 muscle cell development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0061138 morphogenesis of a branching epithelium; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070542 response to fatty acid; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071229 cellular response to acid chemical; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071285 cellular response to lithium ion; GO:0071310 cellular response to organic substance; GO:0071362 cellular response to ether; GO:0071396 cellular response to lipid; GO:0071398 cellular response to fatty acid; GO:0071407 cellular response to organic cyclic compound; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071704 organic substance metabolic process; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090128 regulation of synapse maturation; GO:0090304 nucleic acid metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097659 nucleic acid-templated transcription; GO:0097720 calcineurin-mediated signaling; GO:0099177 regulation of trans-synaptic signaling; GO:0104004 cellular response to environmental stimulus; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902893 regulation of miRNA transcription; GO:1902894 negative regulation of miRNA transcription; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production; GO:1904636 response to ionomycin; GO:1904637 cellular response to ionomycin; GO:1905809 negative regulation of synapse organization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000171 negative regulation of dendrite development; GO:2000297 negative regulation of synapse maturation; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0042975 peroxisome proliferator activated receptor binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00554; PF16179","PF00554 Rel homology DNA-binding domain; PF16179 Rel homology dimerisation domain",{"$nulls":3},"WP2380 BRAINDERIVED NEUROTROPHIC FACTOR BDNF SIGNALING PATHWAY;WP4585 CANCER IMMUNOTHERAPY BY PD1 BLOCKADE;WP1591 HEART DEVELOPMENT;WP4666 HEPATITIS B INFECTION;WP4754 IL18 SIGNALING PATHWAY;WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP1528 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART;WP428 WNT SIGNALING","http://www.wikipathways.org/instance/WP2380_r120727;http://www.wikipathways.org/instance/WP4585_r108119;http://www.wikipathways.org/instance/WP1591_r118366;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP3414_r106735;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP1528_r116468;http://www.wikipathways.org/instance/WP428_r116549","Transcription factor"]
["Q14CB8","Rho GTPase-activating protein 19 OS=Homo sapiens OX=9606 GN=ARHGAP19 PE=1 SV=1","ARHGAP19",1.060637036,0.242967537,"nochange",7709.97,7801.22,7527.7,8816.79,7848.38,7770.73,0.974408102,0.985940538,0.951372297,1.114291185,0.991900754,0.982087125,"nucleus","K20640",null,null,"GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0007275 multicellular organism development; GO:0007444 imaginal disc development; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035218 leg disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0048513 animal organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:1902531 regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0005096 GTPase activator activity; GO:0008047 enzyme activator activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00620","PF00620 RhoGAP domain","T","KOG1453","Chimaerin and related Rho GTPase activating proteins",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q15007","Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2","WTAP",1.173480408,0.006345197,"up",14425.2,14912.8,13996,17525.4,16158.6,17167.6,0.918943023,0.950005096,0.891601264,1.116438182,1.029367547,1.093644888,"nucleus","K22824",null,null,"GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0001510 RNA methylation; GO:0001654 eye development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0007530 sex determination; GO:0007538 primary sex determination; GO:0007539 primary sex determination"," soma; GO:0007542 primary sex determination"," germ-line; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009451 RNA modification; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016556 mRNA modification; GO:0018992 germ-line sex determination; GO:0018993 somatic sex determination; GO:0019099 female germ-line sex determination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0030237 female sex determination; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032259 methylation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0040029 regulation of gene expression"," epigenetic; GO:0042981 regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070828 heterochromatin organization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080009 mRNA methylation; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0036396 RNA N6-methyladenosine methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045293 mRNA editing complex; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"A","KOG2991","Splicing regulator",{"$nulls":3},"R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q15051","IQ calmodulin-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=IQCB1 PE=1 SV=1","IQCB1",0.22954185,{"v":6.03375e-06,"d":"6.03E-06"},"down",8838.27,8826.97,8985.63,1898.48,2222.1,1996.91,1.618317792,1.616248723,1.645299917,0.347618251,0.406874192,0.365641125,"cytoplasm","K16774",null,null,"GO:0001894 tissue homeostasis; GO:0001895 retina homeostasis; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0042592 homeostatic process; GO:0044085 cellular component biogenesis; GO:0044782 cilium organization; GO:0045494 photoreceptor cell maintenance; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0048496 maintenance of animal organ identity; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048871 multicellular organismal homeostasis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051179 localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0060249 anatomical structure homeostasis; GO:0060271 cilium assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0097711 ciliary basal body-plasma membrane docking; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:0140056 organelle localization by membrane tethering;","GO:0001750 photoreceptor outer segment; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005929 cilium; GO:0015630 microtubule cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032391 photoreceptor connecting cilium; GO:0035869 ciliary transition zone; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045171 intercellular bridge; GO:0070013 intracellular organelle lumen; GO:0072686 mitotic spindle; GO:0097730 non-motile cilium; GO:0097731 9+0 non-motile cilium; GO:0097733 photoreceptor cell cilium; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0019899 enzyme binding;",null,null,"Z","KOG0160","Myosin class V heavy chain","WP4352 CILIARY LANDSCAPE;WP4803 CILIOPATHIES","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP4803_r110008",null,"R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-5617833 Cilium Assembly;R-HSA-5620912 Anchoring of the basal body to the plasma membrane","https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620912"]
["Q15072","Zinc finger protein OZF OS=Homo sapiens OX=9606 GN=ZNF146 PE=1 SV=2","ZNF146",1.017844415,0.870618457,"nochange",6151.59,6308.88,6943.36,6220.06,5992.07,7537.95,0.942678266,0.966781606,1.06401021,0.953170705,0.918233198,1.155126014,"nucleus",{"$nulls":3},"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005539 glycosaminoglycan binding; GO:0008201 heparin binding; GO:0008270 zinc ion binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1901681 sulfur compound binding;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["Q15149","Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3","PLEC",1.506562077,{"v":1.15198e-05,"d":"1.15E-05"},"up",39300.2,38530.9,39707.9,60468.5,58015,58596.3,0.80036033,0.784693305,0.808663262,1.231459092,1.181492831,1.193331179,"cytoplasm","nucleus","K10388",null,null,"GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001558 regulation of cell growth; GO:0001578 microtubule bundle formation; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001709 cell fate determination; GO:0001763 morphogenesis of a branching structure; GO:0001952 regulation of cell-matrix adhesion; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0006810 transport; GO:0006892 post-Golgi vesicle-mediated transport; GO:0006893 Golgi to plasma membrane transport; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007026 negative regulation of microtubule depolymerization; GO:0007044 cell-substrate junction assembly; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007229 integrin-mediated signaling pathway; GO:0007267 cell-cell signaling; GO:0007275 multicellular organism development; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007475 apposition of dorsal and ventral imaginal disc-derived wing surfaces; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007517 muscle organ development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007565 female pregnancy; GO:0007584 response to nutrient; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008088 axo-dendritic transport; GO:0008090 retrograde axonal transport; GO:0008104 protein localization; GO:0008219 cell death; GO:0008361 regulation of cell size; GO:0008587 imaginal disc-derived wing margin morphogenesis; GO:0009605 response to external stimulus; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010466 negative regulation of peptidase activity; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010951 negative regulation of endopeptidase activity; GO:0010955 negative regulation of protein processing; GO:0010970 transport along microtubule; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016198 axon choice point recognition; GO:0016199 axon midline choice point recognition; GO:0016203 muscle attachment; GO:0016204 determination of muscle attachment site; GO:0016319 mushroom body development; GO:0016331 morphogenesis of embryonic epithelium; GO:0016358 dendrite development; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030011 maintenance of cell polarity; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030036 actin cytoskeleton organization; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030162 regulation of proteolysis; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030334 regulation of cell migration; GO:0030516 regulation of axon extension; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0030716 oocyte fate determination; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0031110 regulation of microtubule polymerization or depolymerization; GO:0031111 negative regulation of microtubule polymerization or depolymerization; GO:0031114 regulation of microtubule depolymerization; GO:0031122 cytoplasmic microtubule organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031581 hemidesmosome assembly; GO:0031667 response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034613 cellular protein localization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035146 tube fusion; GO:0035147 branch fusion"," open tracheal system; GO:0035148 tube formation; GO:0035149 lumen formation"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043001 Golgi to plasma membrane protein transport; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043242 negative regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043622 cortical microtubule organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045103 intermediate filament-based process; GO:0045104 intermediate filament cytoskeleton organization; GO:0045165 cell fate commitment; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045773 positive regulation of axon extension; GO:0045861 negative regulation of proteolysis; GO:0045927 positive regulation of growth; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051893 regulation of focal adhesion assembly; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060378 regulation of brood size; GO:0060429 epithelium development; GO:0060446 branching involved in open tracheal system development; GO:0060491 regulation of cell projection assembly; GO:0060538 skeletal muscle organ development; GO:0060541 respiratory system development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0061061 muscle structure development; GO:0061138 morphogenesis of a branching epithelium; GO:0061387 regulation of extent of cell growth; GO:0061564 axon development; GO:0061951 establishment of protein localization to plasma membrane; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070613 regulation of protein processing; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0080154 regulation of fertilization; GO:0090066 regulation of anatomical structure size; GO:0090109 regulation of cell-substrate junction assembly; GO:0090150 establishment of protein localization to membrane; GO:0090727 positive regulation of brood size; GO:0097340 inhibition of cysteine-type endopeptidase activity; GO:0097341 zymogen inhibition; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0098876 vesicle-mediated transport to the plasma membrane; GO:0098930 axonal transport; GO:0099111 microtubule-based transport; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901879 regulation of protein depolymerization; GO:1901880 negative regulation of protein depolymerization; GO:1901888 regulation of cell junction assembly; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1903317 regulation of protein maturation; GO:1903318 negative regulation of protein maturation; GO:1903391 regulation of adherens junction organization; GO:1904747 positive regulation of apoptotic process involved in development; GO:1904748 regulation of apoptotic process involved in development; GO:1905516 positive regulation of fertilization; GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2000145 regulation of cell motility; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process;","GO:0000235 astral microtubule; GO:0001726 ruffle; GO:0005576 extracellular region; GO:0005604 basement membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005818 aster; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0005881 cytoplasmic microtubule; GO:0005886 plasma membrane; GO:0005903 brush border; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0005927 muscle tendon junction; GO:0009925 basal plasma membrane; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0016528 sarcoplasm; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0030056 hemidesmosome; GO:0030175 filopodium; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031012 extracellular matrix; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031674 I band; GO:0031982 vesicle; GO:0032587 ruffle membrane; GO:0032991 protein-containing complex; GO:0035371 microtubule plus-end; GO:0042383 sarcolemma; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043034 costamere; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0044295 axonal growth cone; GO:0045111 intermediate filament cytoskeleton; GO:0045169 fusome; GO:0045177 apical part of cell; GO:0045178 basal part of cell; GO:0048471 perinuclear region of cytoplasm; GO:0062023 collagen-containing extracellular matrix; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097179 protease inhibitor complex; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1904090 peptidase inhibitor complex; GO:1990752 microtubule end;","GO:0002020 protease binding; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0004869 cysteine-type endopeptidase inhibitor activity; GO:0005102 signaling receptor binding; GO:0005178 integrin binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008022 protein C-terminus binding; GO:0008092 cytoskeletal protein binding; GO:0008307 structural constituent of muscle; GO:0015631 tubulin binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0030506 ankyrin binding; GO:0035375 zymogen binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process; GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0047485 protein N-terminus binding; GO:0050839 cell adhesion molecule binding; GO:0051010 microtubule plus-end binding; GO:0051011 microtubule minus-end binding; GO:0051015 actin filament binding; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0089720 caspase binding; GO:0098772 molecular function regulator;","PF03501; PF00307; PF17902; PF18373","PF03501 Plectin/S10 domain; PF00307 Calponin homology (CH) domain; PF17902 SH3 domain; PF18373 Spectrin like domain","J","KOG3344","40s ribosomal protein s10","WP4535 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY","http://www.wikipathways.org/instance/WP4535_r109210",null,"R-HSA-109581 Apoptosis;R-HSA-111465 Apoptotic cleavage of cellular proteins;R-HSA-1474244 Extracellular matrix organization;R-HSA-1474290 Collagen formation;R-HSA-1500931 Cell-Cell communication;R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures;R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins;R-HSA-446107 Type I hemidesmosome assembly;R-HSA-446728 Cell junction organization;R-HSA-5357801 Programmed Cell Death;R-HSA-75153 Apoptotic execution phase","https://reactome.org/PathwayBrowser/#/R-HSA-109581;https://reactome.org/PathwayBrowser/#/R-HSA-111465;https://reactome.org/PathwayBrowser/#/R-HSA-1474244;https://reactome.org/PathwayBrowser/#/R-HSA-1474290;https://reactome.org/PathwayBrowser/#/R-HSA-1500931;https://reactome.org/PathwayBrowser/#/R-HSA-2022090;https://reactome.org/PathwayBrowser/#/R-HSA-264870;https://reactome.org/PathwayBrowser/#/R-HSA-446107;https://reactome.org/PathwayBrowser/#/R-HSA-446728;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-75153","IL2 STAT5 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING"]
["Q15311","RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3","RALBP1",0.510056783,0.002493567,"down",7074.36,5574.36,6073.47,3138.34,3597.63,2813.41,1.50137258,1.183031576,1.288956361,0.666041539,0.763515433,0.597082511,"cytoplasm","K08773","RALBP1; RalA-binding protein 1","hsa04014 Ras signaling pathway; hsa05200 Pathways in cancer; hsa05212 Pancreatic cancer","GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006855 xenobiotic transmembrane transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0008285 negative regulation of cell population proliferation; GO:0009605 response to external stimulus; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0015695 organic cation transport; GO:0015850 organic hydroxy compound transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0035556 intracellular signal transduction; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043523 regulation of neuron apoptotic process; GO:0043525 positive regulation of neuron apoptotic process; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0046578 regulation of Ras protein signal transduction; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048662 negative regulation of smooth muscle cell proliferation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0098657 import into cell; GO:1900407 regulation of cellular response to oxidative stress; GO:1900409 positive regulation of cellular response to oxidative stress; GO:1900753 doxorubicin transport; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901264 carbohydrate derivative transport; GO:1901656 glycoside transport; GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902882 regulation of response to oxidative stress; GO:1902884 positive regulation of response to oxidative stress; GO:1903047 mitotic cell cycle process; GO:1903201 regulation of oxidative stress-induced cell death; GO:1903203 regulation of oxidative stress-induced neuron death; GO:1903209 positive regulation of oxidative stress-induced cell death; GO:1903223 positive regulation of oxidative stress-induced neuron death; GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0005096 GTPase activator activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0015399 primary active transmembrane transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019899 enzyme binding; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00620","PF00620 RhoGAP domain","T","KOG4370","Ral-GTPase effector RLIP76","WP437 EGFEGFR SIGNALING PATHWAY;WP4263 PANCREATIC ADENOCARCINOMA PATHWAY;WP2290 RALA DOWNSTREAM REGULATED GENES;WP4223 RAS SIGNALING","http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP4263_r105482;http://www.wikipathways.org/instance/WP2290_r79988;http://www.wikipathways.org/instance/WP4223_r119284",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q15365","Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2","PCBP1",1.147959765,0.00290605,"up",567286,560473,531976,639817,624892,640600,0.954747263,0.943280924,0.895320226,1.076817565,1.051698661,1.078135361,"cytoskeleton","K12889","PCBP1; poly(rC)-binding protein 1","hsa04216 Ferroptosis; hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0016032 viral process; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019058 viral life cycle; GO:0019079 viral genome replication; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0039694 viral RNA genome replication; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045727 positive regulation of translation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003697 single-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0005488 binding; GO:0008494 translation activator activity; GO:0043565 sequence-specific DNA binding; GO:0045182 translation regulator activity; GO:0090079 translation regulator activity"," nucleic acid binding; GO:0097159 organic cyclic compound binding; GO:0098847 sequence-specific single stranded DNA binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00013","PF00013 KH domain","AR","KOG2190","PolyC-binding proteins alphaCP-1 and related KH domain proteins","WP4313 FERROPTOSIS","http://www.wikipathways.org/instance/WP4313_r120500","Transcription factor","R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["Q15468","SCL-interrupting locus protein OS=Homo sapiens OX=9606 GN=STIL PE=1 SV=2","STIL",0.777533297,0.305108183,"nochange",1394.94,2526.15,1650.8,1289.94,1653.38,1389.01,0.845057965,1.53034767,1.000058561,0.781448716,1.001621531,0.841465557,"nucleus","K16724",null,null,"GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000578 embryonic axis specification; GO:0001701 in utero embryonic development; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001947 heart looping; GO:0002009 morphogenesis of an epithelium; GO:0003007 heart morphogenesis; GO:0003143 embryonic heart tube morphogenesis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007098 centrosome cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007275 multicellular organism development; GO:0007368 determination of left/right symmetry; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007507 heart development; GO:0008104 protein localization; GO:0008283 cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009799 specification of symmetry; GO:0009855 determination of bilateral symmetry; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010171 body morphogenesis; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010824 regulation of centrosome duplication; GO:0010941 regulation of cell death; GO:0014020 primary neural tube formation; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0021915 neural tube development; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030900 forebrain development; GO:0030903 notochord development; GO:0031023 microtubule organizing center organization; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032886 regulation of microtubule-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033365 protein localization to organelle; GO:0033504 floor plate development; GO:0033674 positive regulation of kinase activity; GO:0034613 cellular protein localization; GO:0035050 embryonic heart tube development; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035264 multicellular organism growth; GO:0035295 tube development; GO:0040007 growth; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044380 protein localization to cytoskeleton; GO:0044782 cilium organization; GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045787 positive regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046599 regulation of centriole replication; GO:0046605 regulation of centrosome cycle; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051298 centrosome duplication; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060271 cilium assembly; GO:0060322 head development; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0061371 determination of heart left/right asymmetry; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070050 neuron cellular homeostasis; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071539 protein localization to centrosome; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072175 epithelial tube formation; GO:0072359 circulatory system development; GO:0072698 protein localization to microtubule cytoskeleton; GO:0080090 regulation of primary metabolic process; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1902115 regulation of organelle assembly; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904031 positive regulation of cyclin-dependent protein kinase activity; GO:1905508 protein localization to microtubule organizing center; GO:1905515 non-motile cilium assembly;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005814 centriole; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;",{"$nulls":11},"ESTROGEN RESPONSE LATE;G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["Q15633","RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3","TARBP2",0.874887909,0.065680315,"nochange",14145.4,14289,14388,11444.7,13772.2,12247.9,1.057109975,1.067841449,1.075239889,0.855282037,1.0292201,0.915306549,"nucleus","K18420",null,null,"GO:0000003 reproduction; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002698 negative regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006417 regulation of translation; GO:0006469 negative regulation of protein kinase activity; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007292 female gamete generation; GO:0007338 single fertilization; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007549 dosage compensation; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008356 asymmetric cell division; GO:0009047 dosage compensation by hyperactivation of X chromosome; GO:0009566 fertilization; GO:0009611 response to wounding; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010586 miRNA metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0014070 response to organic cyclic compound; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016246 RNA interference; GO:0016441 posttranscriptional gene silencing; GO:0017145 stem cell division; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030154 cell differentiation; GO:0030422 production of siRNA involved in RNA interference; GO:0030423 targeting of mRNA for destruction involved in RNA interference; GO:0030718 germ-line stem cell population maintenance; GO:0031047 gene silencing by RNA; GO:0031050 dsRNA processing; GO:0031054 pre-miRNA processing; GO:0031099 regeneration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033673 negative regulation of kinase activity; GO:0034248 regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0035087 siRNA loading onto RISC involved in RNA interference; GO:0035194 post-transcriptional gene silencing by RNA; GO:0035195 gene silencing by miRNA; GO:0035196 production of miRNAs involved in gene silencing by miRNA; GO:0035264 multicellular organism growth; GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA; GO:0040007 growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042060 wound healing; GO:0042078 germ-line stem cell division; GO:0042221 response to chemical; GO:0042246 tissue regeneration; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043331 response to dsRNA; GO:0043403 skeletal muscle tissue regeneration; GO:0043549 regulation of kinase activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045727 positive regulation of translation; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0046782 regulation of viral transcription; GO:0048132 female germ-line stem cell asymmetric division; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050687 negative regulation of defense response to virus; GO:0050688 regulation of defense response to virus; GO:0050689 negative regulation of defense response to virus by host; GO:0050691 regulation of defense response to virus by host; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051147 regulation of muscle cell differentiation; GO:0051149 positive regulation of muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051301 cell division; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060964 regulation of gene silencing by miRNA; GO:0060966 regulation of gene silencing by RNA; GO:0061351 neural precursor cell proliferation; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0070918 production of small RNA involved in gene silencing by RNA; GO:0070920 regulation of production of small RNA involved in gene silencing by RNA; GO:0070922 small RNA loading onto RISC; GO:0071310 cellular response to organic substance; GO:0071359 cellular response to dsRNA; GO:0071407 cellular response to organic cyclic compound; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:0098722 asymmetric stem cell division; GO:0098727 maintenance of cell number; GO:0098728 germline stem cell asymmetric division; GO:1901360 organic cyclic compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0070578 RISC-loading complex; GO:1902494 catalytic complex; GO:1902555 endoribonuclease complex; GO:1905348 endonuclease complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003725 double-stranded RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0035197 siRNA binding; GO:0036002 pre-mRNA binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043021 ribonucleoprotein complex binding; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0047485 protein N-terminus binding; GO:0061980 regulatory RNA binding; GO:0070883 pre-miRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1905172 RISC complex binding;","PF00035","PF00035 Double-stranded RNA binding motif","UK","KOG3732","Staufen and related double-stranded-RNA-binding proteins","WP4549 FRAGILE X SYNDROME;WP4844 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING;WP2338 MIRNA BIOGENESIS;WP4879 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES","http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP4844_r120398;http://www.wikipathways.org/instance/WP2338_r117159;http://www.wikipathways.org/instance/WP4879_r120399",null,"R-HSA-203927 MicroRNA (miRNA) biogenesis;R-HSA-211000 Gene Silencing by RNA;R-HSA-426486 Small interfering RNA (siRNA) biogenesis;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-203927;https://reactome.org/PathwayBrowser/#/R-HSA-211000;https://reactome.org/PathwayBrowser/#/R-HSA-426486;https://reactome.org/PathwayBrowser/#/R-HSA-74160","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["Q15650","Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4","TRIP4",0.785334649,0.020368473,"nochange",12359.8,13366.2,11049.8,9131.89,9524.22,10225.2,1.129486205,1.221454919,1.009773351,0.834507337,0.870359966,0.934418222,"cytoplasm","K23398",null,null,"GO:0002119 nematode larval development; GO:0002164 larval development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006810 transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0014070 response to organic cyclic compound; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030520 intracellular estrogen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032870 cellular response to hormone stimulus; GO:0033993 response to lipid; GO:0040024 dauer larval development; GO:0042221 response to chemical; GO:0043401 steroid hormone mediated signaling pathway; GO:0045595 regulation of cell differentiation; GO:0045661 regulation of myoblast differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0080090 regulation of primary metabolic process; GO:1901998 toxin transport; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0016604 nuclear body; GO:0031594 neuromuscular junction; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0099053 activating signal cointegrator 1 complex;","GO:0002020 protease binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0016922 nuclear receptor binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030331 estrogen receptor binding; GO:0035035 histone acetyltransferase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0051427 hormone receptor binding; GO:0140110 transcription regulator activity;","PF06221; PF04266","PF06221 Putative zinc finger motif"," C2HC5-type; PF04266 ASCH domain","K","KOG2845","Activating signal cointegrator 1","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782"]
["Q15746","Myosin light chain kinase"," smooth muscle OS=Homo sapiens OX=9606 GN=MYLK PE=1 SV=4","MYLK",1.338481117,0.000716728,"up",5655.84,5887.67,6066.01,7558.39,8195.74,7815.88,0.824075457,0.85785389,0.883838645,1.101283575,1.194147675,1.138800759,"cytoplasm","K00907","MYLK; myosin-light-chain kinase [EC:2.7.11.18]","hsa04510 Focal adhesion; hsa04270 Vascular smooth muscle contraction; hsa04921 Oxytocin signaling pathway; hsa04020 Calcium signaling pathway; hsa04371 Apelin signaling pathway; hsa04810 Regulation of actin cytoskeleton; hsa04611 Platelet activation; hsa04971 Gastric acid secretion; hsa04022 cGMP-PKG signaling pathway","GO:0001568 blood vessel development; GO:0001944 vasculature development; GO:0003008 system process; GO:0003012 muscle system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006936 muscle contraction; GO:0006939 smooth muscle contraction; GO:0006950 response to stress; GO:0006970 response to osmotic stress; GO:0006971 hypotonic response; GO:0007275 multicellular organism development; GO:0007517 muscle organ development; GO:0008152 metabolic process; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010959 regulation of metal ion transport; GO:0014820 tonic smooth muscle contraction; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0019538 protein metabolic process; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0032060 bleb assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0033554 cellular response to stress; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035864 response to potassium ion; GO:0035865 cellular response to potassium ion; GO:0035904 aorta development; GO:0035909 aorta morphogenesis; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048644 muscle organ morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048745 smooth muscle tissue development; GO:0048844 artery morphogenesis; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051592 response to calcium ion; GO:0051716 cellular response to stimulus; GO:0051924 regulation of calcium ion transport; GO:0051928 positive regulation of calcium ion transport; GO:0060414 aorta smooth muscle tissue morphogenesis; GO:0060415 muscle tissue morphogenesis; GO:0060537 muscle tissue development; GO:0060840 artery development; GO:0061041 regulation of wound healing; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071277 cellular response to calcium ion; GO:0071470 cellular response to osmotic stress; GO:0071476 cellular hypotonic response; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080134 regulation of response to stress; GO:0090303 positive regulation of wound healing; GO:0104004 cellular response to environmental stimulus; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1901564 organonitrogen compound metabolic process; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0001725 stress fiber; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0031252 cell leading edge; GO:0032153 cell division site; GO:0032154 cleavage furrow; GO:0032432 actin filament bundle; GO:0042641 actomyosin; GO:0042995 cell projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0097517 contractile actin filament bundle; GO:0098590 plasma membrane region; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004687 myosin light chain kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019899 enzyme binding; GO:0140096 catalytic activity"," acting on a protein;","PF07679; PF00041; PF00069","PF07679 Immunoglobulin I-set domain; PF00041 Fibronectin type III domain; PF00069 Protein kinase domain","Z","KOG0613","Projectin/twitchin and related proteins","WP4962 AIRWAY SMOOTH MUSCLE CELL CONTRACTION;WP2197 ENDOTHELIN PATHWAYS;WP306 FOCAL ADHESION;WP4560 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP3680 PHYSICOCHEMICAL FEATURES AND TOXICITYASSOCIATED PATHWAYS;WP51 REGULATION OF ACTIN CYTOSKELETON","http://www.wikipathways.org/instance/WP4962_r120588;http://www.wikipathways.org/instance/WP2197_r117710;http://www.wikipathways.org/instance/WP306_r116784;http://www.wikipathways.org/instance/WP4560_r108134;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP3680_r117651;http://www.wikipathways.org/instance/WP51_r116716",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-397014 Muscle contraction;R-HSA-445355 Smooth Muscle Contraction;R-HSA-5627123 RHO GTPases activate PAKs;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-397014;https://reactome.org/PathwayBrowser/#/R-HSA-445355;https://reactome.org/PathwayBrowser/#/R-HSA-5627123;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","ADIPOGENESIS;EPITHELIAL MESENCHYMAL TRANSITION;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["Q15800","Methylsterol monooxygenase 1 OS=Homo sapiens OX=9606 GN=MSMO1 PE=1 SV=1","MSMO1",0.668052722,0.055472691,"nochange",3860.92,4502.29,4779.6,3813.73,2546.92,2419.44,1.05668137,1.232215628,1.308111609,1.043766108,0.697057415,0.66216787,"extracellular","K07750","MESO1; methylsterol monooxygenase [EC:1.14.18.9]","hsa00100 Steroid biosynthesis; hsa01100 Metabolic pathways","GO:0006066 alcohol metabolic process; GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006694 steroid biosynthetic process; GO:0006695 cholesterol biosynthetic process; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008203 cholesterol metabolic process; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0016125 sterol metabolic process; GO:0016126 sterol biosynthetic process; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046165 alcohol biosynthetic process; GO:0071704 organic substance metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1902652 secondary alcohol metabolic process; GO:1902653 secondary alcohol biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000254 C-4 methylsterol oxidase activity; GO:0003824 catalytic activity; GO:0004497 monooxygenase activity; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016709 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen"," NAD(P)H as one donor"," and incorporation of one atom of oxygen;",null,null,"I","KOG0873","C-4 sterol methyl oxidase","WP197 CHOLESTEROL BIOSYNTHESIS PATHWAY;WP4718 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCHRUSSELL PATHWAYS","http://www.wikipathways.org/instance/WP197_r120482;http://www.wikipathways.org/instance/WP4718_r119764",null,"R-HSA-1430728 Metabolism;R-HSA-191273 Cholesterol biosynthesis;R-HSA-556833 Metabolism of lipids;R-HSA-8957322 Metabolism of steroids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-191273;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8957322"]
["Q16222","UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3","UAP1",0.99043134,0.802805826,"nochange",40074.7,39581,38218.7,41851.4,38056.2,36838.9,1.024837088,1.012211615,0.977373286,1.070272938,0.973217646,0.942087427,"cytoplasm","K00972","UAP1; UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase [EC:2.7.7.23 2.7.7.83]","hsa01250 Biosynthesis of nucleotide sugars; hsa00520 Amino sugar and nucleotide sugar metabolism; hsa01100 Metabolic pathways","GO:0001700 embryonic development via the syncytial blastoderm; GO:0001838 embryonic epithelial tube formation; GO:0002009 morphogenesis of an epithelium; GO:0006022 aminoglycan metabolic process; GO:0006023 aminoglycan biosynthetic process; GO:0006030 chitin metabolic process; GO:0006031 chitin biosynthetic process; GO:0006034 cuticle chitin metabolic process; GO:0006035 cuticle chitin biosynthetic process; GO:0006040 amino sugar metabolic process; GO:0006047 UDP-N-acetylglucosamine metabolic process; GO:0006048 UDP-N-acetylglucosamine biosynthetic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007413 axonal fasciculation; GO:0007417 central nervous system development; GO:0007424 open tracheal system development; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008152 metabolic process; GO:0008362 chitin-based embryonic cuticle biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009225 nucleotide-sugar metabolic process; GO:0009226 nucleotide-sugar biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010560 positive regulation of glycoprotein biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030198 extracellular matrix organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035148 tube formation; GO:0035150 regulation of tube size; GO:0035151 regulation of tube size"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040003 chitin-based cuticle development; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042335 cuticle development; GO:0043062 extracellular structure organization; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046349 amino sugar biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050920 regulation of chemotaxis; GO:0050921 positive regulation of chemotaxis; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060049 regulation of protein glycosylation; GO:0060050 positive regulation of protein glycosylation; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060562 epithelial tube morphogenesis; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072175 epithelial tube formation; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0106030 neuron projection fasciculation; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901071 glucosamine-containing compound metabolic process; GO:1901073 glucosamine-containing compound biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902667 regulation of axon guidance; GO:1902669 positive regulation of axon guidance; GO:1903018 regulation of glycoprotein metabolic process; GO:1903020 positive regulation of glycoprotein metabolic process; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0003824 catalytic activity; GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0030246 carbohydrate binding; GO:0042802 identical protein binding; GO:0070569 uridylyltransferase activity;",null,null,"M","KOG2388","UDP-N-acetylglucosamine pyrophosphorylase",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide"," LLO) and transfer to a nascent protein;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine;R-HSA-446219 Synthesis of substrates in N-glycan biosythesis;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446193;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-446210;https://reactome.org/PathwayBrowser/#/R-HSA-446219;https://reactome.org/PathwayBrowser/#/R-HSA-597592","ANDROGEN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ANDROGEN_RESPONSE"]
["Q16394","Exostosin-1 OS=Homo sapiens OX=9606 GN=EXT1 PE=1 SV=2","EXT1",0.816659128,0.416823126,"nochange",2138.32,1581.13,1210.82,1604.72,1410.34,1011.29,1.432451081,1.059191972,0.811122946,1.074994808,0.944780509,0.677458684,"Golgi apparatus","K02366","EXT1; glucuronyl/N-acetylglucosaminyl transferase EXT1 [EC:2.4.1.224 2.4.1.225]","hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000271 polysaccharide biosynthetic process; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001501 skeletal system development; GO:0001503 ossification; GO:0005975 carbohydrate metabolic process; GO:0005976 polysaccharide metabolic process; GO:0006022 aminoglycan metabolic process; GO:0006023 aminoglycan biosynthetic process; GO:0006024 glycosaminoglycan biosynthetic process; GO:0006029 proteoglycan metabolic process; GO:0006040 amino sugar metabolic process; GO:0006044 N-acetylglucosamine metabolic process; GO:0006082 organic acid metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007369 gastrulation; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007492 endoderm development; GO:0007498 mesoderm development; GO:0008152 metabolic process; GO:0008354 germ cell migration; GO:0008589 regulation of smoothened signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0015012 heparan sulfate proteoglycan biosynthetic process; GO:0015014 heparan sulfate proteoglycan biosynthetic process"," polysaccharide chain biosynthetic process; GO:0016043 cellular component organization; GO:0016051 carbohydrate biosynthetic process; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0021537 telencephalon development; GO:0021772 olfactory bulb development; GO:0021988 olfactory lobe development; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030166 proteoglycan biosynthetic process; GO:0030177 positive regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030201 heparan sulfate proteoglycan metabolic process; GO:0030202 heparin metabolic process; GO:0030203 glycosaminoglycan metabolic process; GO:0030210 heparin biosynthetic process; GO:0030900 forebrain development; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033692 cellular polysaccharide biosynthetic process; GO:0034637 cellular carbohydrate biosynthetic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0035295 tube development; GO:0036465 synaptic vesicle recycling; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044262 cellular carbohydrate metabolic process; GO:0044264 cellular polysaccharide metabolic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045880 positive regulation of smoothened signaling pathway; GO:0048311 mitochondrion distribution; GO:0048312 intracellular distribution of mitochondria; GO:0048468 cell development; GO:0048488 synaptic vesicle endocytosis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048565 digestive tract development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048706 embryonic skeletal system development; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051646 mitochondrion localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0055123 digestive system development; GO:0060322 head development; GO:0060465 pharynx development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0061564 axon development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072498 embryonic skeletal joint development; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090263 positive regulation of canonical Wnt signaling pathway; GO:0097485 neuron projection guidance; GO:0098657 import into cell; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901071 glucosamine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903510 mucopolysaccharide metabolic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008194 UDP-glycosyltransferase activity; GO:0008375 acetylglucosaminyltransferase activity; GO:0015020 glucuronosyltransferase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0019899 enzyme binding; GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046982 protein heterodimerization activity; GO:0046983 protein dimerization activity; GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity;","PF09258","PF09258 Glycosyl transferase family 64 domain","GMW","KOG1021","Acetylglucosaminyltransferase EXT1/exostosin 1","WP2853 ENDODERM DIFFERENTIATION;WP2857 MESODERMAL COMMITMENT PATHWAY;WP4784 PROTEOGLYCAN BIOSYNTHESIS","http://www.wikipathways.org/instance/WP2853_r116557;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP4784_r111633",null,"R-HSA-1430728 Metabolism;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism;R-HSA-1643685 Disease;R-HSA-2022928 HS-GAG biosynthesis;R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism;R-HSA-3656237 Defective EXT2 causes exostoses 2;R-HSA-3656253 Defective EXT1 causes exostoses 1"," TRPS2 and CHDS;R-HSA-3781865 Diseases of glycosylation;R-HSA-5668914 Diseases of metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-1638091;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-2022928;https://reactome.org/PathwayBrowser/#/R-HSA-3560782;https://reactome.org/PathwayBrowser/#/R-HSA-3656237;https://reactome.org/PathwayBrowser/#/R-HSA-3656253;https://reactome.org/PathwayBrowser/#/R-HSA-3781865;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-71387","GLYCOLYSIS;HYPOXIA","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA"]
["Q16584","Mitogen-activated protein kinase kinase kinase 11 OS=Homo sapiens OX=9606 GN=MAP3K11 PE=1 SV=1","MAP3K11",0.913949591,0.230511916,"nochange",3955.93,3585.31,3355.28,3157.82,3598.66,3202.39,1.138102908,1.031477234,0.965298659,0.908490323,1.035317968,0.921312908,"nucleus","K04419","MAP3K11; mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]","hsa04932 Non-alcoholic fatty liver disease; hsa04010 MAPK signaling pathway","GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0000902 cell morphogenesis; GO:0001558 regulation of cell growth; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002165 instar larval or pupal development; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0007017 microtubule-based process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007391 dorsal closure; GO:0007392 initiation of dorsal closure; GO:0007394 dorsal closure"," elongation of leading edge cells; GO:0007399 nervous system development; GO:0007444 imaginal disc development; GO:0007483 genital disc morphogenesis; GO:0007484 imaginal disc-derived genitalia development; GO:0007485 imaginal disc-derived male genitalia development; GO:0007486 imaginal disc-derived female genitalia development; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007568 aging; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008340 determination of adult lifespan; GO:0008360 regulation of cell shape; GO:0008361 regulation of cell size; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009611 response to wounding; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009826 unidimensional cell growth; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016310 phosphorylation; GO:0016331 morphogenesis of embryonic epithelium; GO:0016476 regulation of embryonic cell shape; GO:0018105 peptidyl-serine phosphorylation; GO:0018107 peptidyl-threonine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0018210 peptidyl-threonine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030307 positive regulation of cell growth; GO:0030516 regulation of axon extension; GO:0030539 male genitalia development; GO:0030540 female genitalia development; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031099 regeneration; GO:0031102 neuron projection regeneration; GO:0031103 axon regeneration; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032989 cellular component morphogenesis; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0035112 genitalia morphogenesis; GO:0035126 post-embryonic genitalia morphogenesis; GO:0035215 genital disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040007 growth; GO:0040008 regulation of growth; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042594 response to starvation; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043523 regulation of neuron apoptotic process; GO:0043525 positive regulation of neuron apoptotic process; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045471 response to ethanol; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045773 positive regulation of axon extension; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045995 regulation of embryonic development; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046528 imaginal disc fusion; GO:0046529 imaginal disc fusion"," thorax closure; GO:0046660 female sex differentiation; GO:0046661 male sex differentiation; GO:0046677 response to antibiotic; GO:0046688 response to copper ion; GO:0046777 protein autophosphorylation; GO:0046843 dorsal appendage formation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048678 response to axon injury; GO:0048679 regulation of axon regeneration; GO:0048680 positive regulation of axon regeneration; GO:0048686 regulation of sprouting of injured axon; GO:0048687 positive regulation of sprouting of injured axon; GO:0048690 regulation of axon extension involved in regeneration; GO:0048691 positive regulation of axon extension involved in regeneration; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048803 imaginal disc-derived male genitalia morphogenesis; GO:0048804 imaginal disc-derived female genitalia morphogenesis; GO:0048805 imaginal disc-derived genitalia morphogenesis; GO:0048806 genitalia development; GO:0048807 female genitalia morphogenesis; GO:0048808 male genitalia morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050829 defense response to Gram-negative bacterium; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0061387 regulation of extent of cell growth; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070570 regulation of neuron projection regeneration; GO:0070572 positive regulation of neuron projection regeneration; GO:0070887 cellular response to chemical stimulus; GO:0071236 cellular response to antibiotic; GO:0071310 cellular response to organic substance; GO:0071361 cellular response to ethanol; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0090598 male anatomical structure morphogenesis; GO:0097237 cellular response to toxic substance; GO:0097305 response to alcohol; GO:0097306 cellular response to alcohol; GO:0098542 defense response to other organism; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901214 regulation of neuron death; GO:1901216 positive regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005938 cell cortex; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region;","GO:0000166 nucleotide binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004706 JUN kinase kinase kinase activity; GO:0004708 MAP kinase kinase activity; GO:0004709 MAP kinase kinase kinase activity; GO:0004712 protein serine/threonine/tyrosine kinase activity; GO:0005080 protein kinase C binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008134 transcription factor binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030554 adenyl nucleotide binding; GO:0030971 receptor tyrosine kinase binding; GO:0031267 small GTPase binding; GO:0031434 mitogen-activated protein kinase kinase binding; GO:0031435 mitogen-activated protein kinase kinase kinase binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043425 bHLH transcription factor binding; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0097110 scaffold protein binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1990782 protein tyrosine kinase binding;","PF14604; PF07714","PF14604 Variant SH3 domain; PF07714 Protein tyrosine and serine/threonine kinase","T","KOG0192","Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs","WP3879 4HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION;WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP4659 GASTRIN SIGNALING PATHWAY;WP4877 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING;WP481 INSULIN SIGNALING;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP382 MAPK SIGNALING PATHWAY;WP4396 NONALCOHOLIC FATTY LIVER DISEASE","http://www.wikipathways.org/instance/WP3879_r120671;http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP4877_r119237;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP382_r119087;http://www.wikipathways.org/instance/WP4396_r98945",null,"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-194315 Signaling by Rho GTPases;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5673000 RAF activation;R-HSA-5673001 RAF/MAP kinase cascade;R-HSA-5683057 MAPK family signaling cascades;R-HSA-5684996 MAPK1/MAPK3 signaling;R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants;R-HSA-6802949 Signaling by RAS mutants;R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF;R-HSA-6802957 Oncogenic MAPK signaling;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013408 RHOG GTPase cycle;R-HSA-9013424 RHOV GTPase cycle;R-HSA-9649948 Signaling downstream of RAS mutants;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-5673000;https://reactome.org/PathwayBrowser/#/R-HSA-5673001;https://reactome.org/PathwayBrowser/#/R-HSA-5683057;https://reactome.org/PathwayBrowser/#/R-HSA-5684996;https://reactome.org/PathwayBrowser/#/R-HSA-6802946;https://reactome.org/PathwayBrowser/#/R-HSA-6802949;https://reactome.org/PathwayBrowser/#/R-HSA-6802955;https://reactome.org/PathwayBrowser/#/R-HSA-6802957;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013408;https://reactome.org/PathwayBrowser/#/R-HSA-9013424;https://reactome.org/PathwayBrowser/#/R-HSA-9649948;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q16666","Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3","IFI16",1.282448583,0.00079323,"up",45514.8,41956.6,44392.6,55127,57616.8,56365,0.907353754,0.836419769,0.884982297,1.098976386,1.148611436,1.123656357,"nucleus","K20914","IFI16; gamma-interferon-inducible protein 16","hsa04621 NOD-like receptor signaling pathway","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001558 regulation of cell growth; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002218 activation of innate immune response; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002573 myeloid leukocyte differentiation; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008283 cell population proliferation; GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage; GO:0009267 cellular response to starvation; GO:0009314 response to radiation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010212 response to ionizing radiation; GO:0010466 negative regulation of peptidase activity; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010951 negative regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0016485 protein processing; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030224 monocyte differentiation; GO:0030278 regulation of ossification; GO:0030308 negative regulation of cell growth; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031638 zymogen activation; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032651 regulation of interleukin-1 beta production; GO:0032652 regulation of interleukin-1 production; GO:0032731 positive regulation of interleukin-1 beta production; GO:0032732 positive regulation of interleukin-1 production; GO:0033554 cellular response to stress; GO:0034097 response to cytokine; GO:0035455 response to interferon-alpha; GO:0035456 response to interferon-beta; GO:0035457 cellular response to interferon-alpha; GO:0035458 cellular response to interferon-beta; GO:0035556 intracellular signal transduction; GO:0040008 regulation of growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042149 cellular response to glucose starvation; GO:0042221 response to chemical; GO:0042594 response to starvation; GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043392 negative regulation of DNA binding; GO:0043583 ear development; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044238 primary metabolic process; GO:0045069 regulation of viral genome replication; GO:0045071 negative regulation of viral genome replication; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045667 regulation of osteoblast differentiation; GO:0045669 positive regulation of osteoblast differentiation; GO:0045778 positive regulation of ossification; GO:0045824 negative regulation of innate immune response; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048525 negative regulation of viral process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051604 protein maturation; GO:0051607 defense response to virus; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0072331 signal transduction by p53 class mediator; GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0097190 apoptotic signaling pathway; GO:0097193 intrinsic apoptotic signaling pathway; GO:0097202 activation of cysteine-type endopeptidase activity; GO:0098542 defense response to other organism; GO:0104004 cellular response to environmental stimulus; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903131 mononuclear cell differentiation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903900 regulation of viral life cycle; GO:1903901 negative regulation of viral life cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2000117 negative regulation of cysteine-type endopeptidase activity; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016234 inclusion body; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0034399 nuclear periphery; GO:0042405 nuclear inclusion body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0042802 identical protein binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF02758","PF02758 PAAD/DAPIN/Pyrin domain",{"$nulls":5},"Transcription factor","R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-1834941 STING mediated induction of host immune responses;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-3270619 IRF3-mediated induction of type I IFN","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1834941;https://reactome.org/PathwayBrowser/#/R-HSA-1834949;https://reactome.org/PathwayBrowser/#/R-HSA-3270619"]
["Q16836","Hydroxyacyl-coenzyme A dehydrogenase"," mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3","HADH",0.863467011,0.014685478,"nochange",115122,127355,125771,106451,108626,102893,1.006578085,1.113538263,1.099688437,0.930762527,0.949779808,0.89965288,"mitochondria","K00022","HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]","hsa00062 Fatty acid elongation; hsa00071 Fatty acid degradation; hsa00650 Butanoate metabolism; hsa01212 Fatty acid metabolism; hsa00310 Lysine degradation; hsa00380 Tryptophan metabolism; hsa01100 Metabolic pathways; hsa00280 Valine"," leucine and isoleucine degradation","GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0014823 response to activity; GO:0016042 lipid catabolic process; GO:0016054 organic acid catabolic process; GO:0019395 fatty acid oxidation; GO:0019752 carboxylic acid metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030258 lipid modification; GO:0032787 monocarboxylic acid metabolic process; GO:0032868 response to insulin; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0034440 lipid oxidation; GO:0042221 response to chemical; GO:0043434 response to peptide hormone; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0046676 negative regulation of insulin secretion; GO:0046883 regulation of hormone secretion; GO:0046888 negative regulation of hormone secretion; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0071704 organic substance metabolic process; GO:0072329 monocarboxylic acid catabolic process; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090278 negative regulation of peptide hormone secretion; GO:1901575 organic substance catabolic process; GO:1901652 response to peptide; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity; GO:0016491 oxidoreductase activity; GO:0016614 oxidoreductase activity"," acting on CH-OH group of donors; GO:0016616 oxidoreductase activity"," acting on the CH-OH group of donors"," NAD or NADP as acceptor;",null,null,"I","KOG2304","3-hydroxyacyl-CoA dehydrogenase","WP3925 AMINO ACID METABOLISM;WP143 FATTY ACID BETAOXIDATION;WP357 FATTY ACID BIOSYNTHESIS;WP4754 IL18 SIGNALING PATHWAY;WP368 MITOCHONDRIAL LONG CHAIN FATTY ACID BETAOXIDATION;WP465 TRYPTOPHAN METABOLISM","http://www.wikipathways.org/instance/WP3925_r117062;http://www.wikipathways.org/instance/WP143_r116506;http://www.wikipathways.org/instance/WP357_r117722;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP368_r117795;http://www.wikipathways.org/instance/WP465_r119262",null,"R-HSA-1430728 Metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids;R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation;R-HSA-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA;R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA;R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA;R-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA;R-HSA-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-77286;https://reactome.org/PathwayBrowser/#/R-HSA-77289;https://reactome.org/PathwayBrowser/#/R-HSA-77310;https://reactome.org/PathwayBrowser/#/R-HSA-77346;https://reactome.org/PathwayBrowser/#/R-HSA-77348;https://reactome.org/PathwayBrowser/#/R-HSA-77350;https://reactome.org/PathwayBrowser/#/R-HSA-77352;https://reactome.org/PathwayBrowser/#/R-HSA-8978868","ADIPOGENESIS;APICAL JUNCTION;FATTY ACID METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_APICAL_JUNCTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM"]
["Q2M389","WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2","WASHC4",0.696608288,0.000243875,"down",12169.5,11020.3,11668.7,8158.61,8094.78,8029.33,1.234621132,1.118032398,1.183813929,0.827707984,0.821232298,0.814592259,"cytoplasm","K18465","MRT43; WASH complex subunit 7","hsa04144 Endocytosis","GO:0006810 transport; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0030155 regulation of cell adhesion; GO:0045785 positive regulation of cell adhesion; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0012505 endomembrane system; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071203 WASH complex; GO:0097708 intracellular vesicle;",{"$nulls":3},"S","KOG3578","Uncharacterized conserved protein"]
["Q2TBE0","CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4","CWF19L2",1.819272415,0.000275315,"up",5833.9,5176.47,5265.12,9773.81,10479.4,9356.34,0.76284994,0.676883359,0.688475372,1.278038768,1.370302826,1.223449734,"nucleus","K24940",{"$nulls":7},"S","KOG2477","Uncharacterized conserved protein"]
["Q3ZCQ8","Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2","TIMM50",0.695732099,0.009942801,"down",7659.6,9341.35,9202.8,6549.17,6082.6,5599.02,1.034276489,1.261363345,1.242654926,0.884335024,0.821334034,0.756036183,"mitochondria","K17496",null,null,"GO:0001836 release of cytochrome c from mitochondria; GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008637 apoptotic mitochondrial changes; GO:0009987 cellular process; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016311 dephosphorylation; GO:0017038 protein import; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0030150 protein import into mitochondrial matrix; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0035335 peptidyl-tyrosine dephosphorylation; GO:0036211 protein modification process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0061024 membrane organization; GO:0065002 intracellular protein transmembrane transport; GO:0065007 biological regulation; GO:0070585 protein localization to mitochondrion; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:0097190 apoptotic signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1990542 mitochondrial transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005744 TIM23 mitochondrial import inner membrane translocase complex; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex;","GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004722 protein serine/threonine phosphatase activity; GO:0004725 protein tyrosine phosphatase activity; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005134 interleukin-2 receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0043021 ribonucleoprotein complex binding; GO:0044877 protein-containing complex binding; GO:0070851 growth factor receptor binding; GO:0140096 catalytic activity"," acting on a protein;",null,null,"K","KOG2832","TFIIF-interacting CTD phosphatase"," including NLI-interacting factor (involved in RNA polymerase II regulation)",{"$nulls":3},"R-HSA-1268020 Mitochondrial protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1268020;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["Q4G176","Malonate--CoA ligase ACSF3"," mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3","ACSF3",0.796812597,0.030211619,"nochange",9624.05,11769.3,9995.21,7953.87,8781.16,8275.77,1.023846725,1.252067399,1.063332279,0.846165985,0.934176558,0.880411054,"mitochondria","K18660","ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-]","hsa00061 Fatty acid biosynthesis; hsa00280 Valine"," leucine and isoleucine degradation; hsa01212 Fatty acid metabolism; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0016053 organic acid biosynthetic process; GO:0016054 organic acid catabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035336 long-chain fatty-acyl-CoA metabolic process; GO:0035337 fatty-acyl-CoA metabolic process; GO:0035338 long-chain fatty-acyl-CoA biosynthetic process; GO:0035383 thioester metabolic process; GO:0035384 thioester biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043648 dicarboxylic acid metabolic process; GO:0043649 dicarboxylic acid catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046395 carboxylic acid catabolic process; GO:0046483 heterocycle metabolic process; GO:0046949 fatty-acyl-CoA biosynthetic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071616 acyl-CoA biosynthetic process; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:0090410 malonate catabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0015645 fatty acid ligase activity; GO:0016405 CoA-ligase activity; GO:0016874 ligase activity; GO:0016877 ligase activity"," forming carbon-sulfur bonds; GO:0016878 acid-thiol ligase activity; GO:0031957 very long-chain fatty acid-CoA ligase activity; GO:0090409 malonyl-CoA synthetase activity;","PF13193","PF13193 AMP-binding enzyme C-terminal domain","I","KOG1176","Acyl-CoA synthetase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-75105 Fatty acyl-CoA biosynthesis;R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-75105;https://reactome.org/PathwayBrowser/#/R-HSA-75876;https://reactome.org/PathwayBrowser/#/R-HSA-8978868"]
["Q53ET0","CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2","CRTC2",1.044412619,0.905812995,"nochange","NA",1371.08,1093.76,1039.62,1534.69,"NA","NA",1.08834228,0.868209916,0.825234415,1.218213389,"NA","nucleus","K16333","CRTC2; CREB-regulated transcription coactivator 2","hsa04922 Glucagon signaling pathway; hsa04151 PI3K-Akt signaling pathway; hsa05166 Human T-cell leukemia virus 1 infection; hsa04931 Insulin resistance; hsa04152 AMPK signaling pathway","GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006006 glucose metabolic process; GO:0006094 gluconeogenesis; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016043 cellular component organization; GO:0016051 carbohydrate biosynthetic process; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019318 hexose metabolic process; GO:0019319 hexose biosynthetic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032793 positive regulation of CREB transcription factor activity; GO:0033500 carbohydrate homeostasis; GO:0036211 protein modification process; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043543 protein acylation; GO:0043966 histone H3 acetylation; GO:0043970 histone H3-K9 acetylation; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046364 monosaccharide biosynthetic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0061647 histone H3-K9 modification; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901998 toxin transport; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003682 chromatin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008140 cAMP response element binding protein binding;",{"$nulls":5},"WP1403 AMPACTIVATED PROTEIN KINASE AMPK SIGNALING;WP3932 FOCAL ADHESION PI3KAKTMTORSIGNALING PATHWAY","http://www.wikipathways.org/instance/WP1403_r116516;http://www.wikipathways.org/instance/WP3932_r120304","Transcription factor","R-HSA-1592230 Mitochondrial biogenesis;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis;R-HSA-2262752 Cellular responses to stress;R-HSA-400253 Circadian Clock;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9707616 Heme signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-2151201;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-400253;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9707616"]
["Q53TQ3","INO80 complex subunit D OS=Homo sapiens OX=9606 GN=INO80D PE=1 SV=3","INO80D",0.784770138,0.456204102,"nochange",1459.91,1762.01,857.723,761.482,1034.84,1405.26,1.203020096,1.451961723,0.706795628,0.627489468,0.852746619,1.157986465,"nucleus","K11668",null,null,"GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009629 response to gravity; GO:0009987 cellular process; GO:0016579 protein deubiquitination; GO:0019538 protein metabolic process; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0042330 taxis; GO:0042332 gravitaxis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0050896 response to stimulus; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",null,"PF13891","PF13891 Potential DNA-binding domain",{"$nulls":3},"WP2361 GASTRIC CANCER NETWORK 1","http://www.wikipathways.org/instance/WP2361_r117731",null,"R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5696394 DNA Damage Recognition in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-597592 Post-translational protein modification;R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689603;https://reactome.org/PathwayBrowser/#/R-HSA-5696394;https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-5696399;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73894"]
["Q5BJD5","Transmembrane protein 41B OS=Homo sapiens OX=9606 GN=TMEM41B PE=1 SV=1","TMEM41B",1.361598989,0.404174017,"nochange",1157.26,"NA",497.469,865.046,1012.25,1502.32,1.149365012,"NA",0.494075197,0.859144536,1.00534429,1.492070965,"plasma membrane",{"$nulls":3},"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0008045 motor neuron axon guidance; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016043 cellular component organization; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0032222 regulation of synaptic transmission"," cholinergic; GO:0032224 positive regulation of synaptic transmission"," cholinergic; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050896 response to stimulus; GO:0061564 axon development; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0097485 neuron projection guidance; GO:0099177 regulation of trans-synaptic signaling; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis;",{"$nulls":4},"S","KOG3140","Predicted membrane protein"]
["Q5H9F3","BCL-6 corepressor-like protein 1 OS=Homo sapiens OX=9606 GN=BCORL1 PE=1 SV=2","BCORL1",1.33496864,0.658753887,"nochange","NA",1936.54,2631.41,4163.42,1934.65,"NA","NA",0.726246529,0.986838577,1.561377158,0.725537736,"NA","nucleus","K26199",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;",null,"PF16553","PF16553 BCORL-PCGF1-binding domain",{"$nulls":3},"WP2853 ENDODERM DIFFERENTIATION;WP2857 MESODERMAL COMMITMENT PATHWAY;WP3651 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA","http://www.wikipathways.org/instance/WP2853_r116557;http://www.wikipathways.org/instance/WP2857_r118395;http://www.wikipathways.org/instance/WP3651_r116547"]
["Q5J8M3","ER membrane protein complex subunit 4 OS=Homo sapiens OX=9606 GN=EMC4 PE=1 SV=2","EMC4",0.87278776,0.023334367,"nochange",20446.3,19410.1,19930.3,18092.9,16192.2,17896,1.0956525,1.040125822,1.068001693,0.969541243,0.867688746,0.958989995,"cytoplasm","K23565",null,null,"GO:0006457 protein folding; GO:0009987 cellular process; GO:0034975 protein folding in endoplasmic reticulum;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0072546 EMC complex; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;",{"$nulls":3},"S","KOG3318","Predicted membrane protein"]
["Q5NDL2","EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1","EOGT",0.767346965,0.012097774,"nochange",11543.7,13217,13467.6,9835.87,9142,10356.5,1.025154867,1.173754678,1.196009572,0.87348857,0.811868447,0.919723865,"endoplasmic reticulum","K18134","EOGT; EGF domain-specific O-GlcNAc transferase [EC:2.4.1.255]","hsa00514 Other types of O-glycan biosynthesis","GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002168 instar larval development; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007591 molting cycle"," chitin-based cuticle; GO:0008152 metabolic process; GO:0008363 larval chitin-based cuticle development; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009791 post-embryonic development; GO:0009987 cellular process; GO:0018193 peptidyl-amino acid modification; GO:0018210 peptidyl-threonine modification; GO:0018243 protein O-linked glycosylation via threonine; GO:0019538 protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0040003 chitin-based cuticle development; GO:0042303 molting cycle; GO:0042335 cuticle development; GO:0042337 cuticle development involved in chitin-based cuticle molting cycle; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048856 anatomical structure development; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0097370 protein O-GlcNAcylation via threonine; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0008194 UDP-glycosyltransferase activity; GO:0008375 acetylglucosaminyltransferase activity; GO:0016262 protein N-acetylglucosaminyltransferase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0097363 protein O-GlcNAc transferase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"S","KOG4698","Uncharacterized conserved protein"]
["Q5SNT2","Transmembrane protein 201 OS=Homo sapiens OX=9606 GN=TMEM201 PE=1 SV=1","TMEM201",1.296497531,0.011137772,"nochange",8428.48,7716.76,7107.5,10199.8,10502.1,9445.22,0.947022708,0.867053959,0.798597599,1.146047948,1.18001433,1.061263456,"plasma membrane",{"$nulls":3},"GO:0001667 ameboidal-type cell migration; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006998 nuclear envelope organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007097 nuclear migration; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010761 fibroblast migration; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0030473 nuclear migration along microtubule; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0040011 locomotion; GO:0046907 intracellular transport; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051642 centrosome localization; GO:0051647 nucleus localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0061024 membrane organization; GO:0061842 microtubule organizing center localization; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0072384 organelle transport along microtubule; GO:0090435 protein localization to nuclear envelope; GO:0099111 microtubule-based transport;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005637 nuclear inner membrane; GO:0005639 integral component of nuclear inner membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031229 intrinsic component of nuclear inner membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005521 lamin binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;",null,null,"S","KOG4623","Uncharacterized conserved protein"]
["Q5T160","Probable arginine--tRNA ligase"," mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1","RARS2",0.803682075,0.024413186,"nochange",15527,15311.1,14044.2,13195.9,10939.3,11935.9,1.150810219,1.134808421,1.040909956,0.978036747,0.81078497,0.884649687,"mitochondria","K01887","RARS; arginyl-tRNA synthetase [EC:6.1.1.19]","hsa00970 Aminoacyl-tRNA biosynthesis","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006420 arginyl-tRNA aminoacylation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032543 mitochondrial translation; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0140053 mitochondrial gene expression; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004812 aminoacyl-tRNA ligase activity; GO:0004814 arginine-tRNA ligase activity; GO:0016874 ligase activity; GO:0016875 ligase activity"," forming carbon-oxygen bonds; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF05746","PF05746 DALR anticodon binding domain","J","KOG1195","Arginyl-tRNA synthetase",{"$nulls":3},"R-HSA-379724 tRNA Aminoacylation;R-HSA-379726 Mitochondrial tRNA aminoacylation;R-HSA-392499 Metabolism of proteins;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-379724;https://reactome.org/PathwayBrowser/#/R-HSA-379726;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q5T8D3","Acyl-CoA-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=ACBD5 PE=1 SV=1","ACBD5",0.995207601,0.850990074,"nochange",6368.01,6082.44,6502.48,6256.63,6421.97,6183.5,1.010393486,0.965082931,1.031729447,0.992721148,1.018955161,0.981117825,"cytoplasm",{"$nulls":3},"GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006914 autophagy; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0016042 lipid catabolic process; GO:0016054 organic acid catabolic process; GO:0019752 carboxylic acid metabolic process; GO:0019915 lipid storage; GO:0030242 autophagy of peroxisome; GO:0032787 monocarboxylic acid metabolic process; GO:0033036 macromolecule localization; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0051179 localization; GO:0051235 maintenance of location; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0072329 monocarboxylic acid catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031903 microbody membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;",null,"PF00887","PF00887 Acyl CoA binding protein","I","KOG0817","Acyl-CoA-binding protein",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-390918 Peroxisomal lipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8978868 Fatty acid metabolism;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9603798 Class I peroxisomal membrane protein import;R-HSA-9609507 Protein localization;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-390918;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9603798;https://reactome.org/PathwayBrowser/#/R-HSA-9609507;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q5TC82","Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1","RC3H1",0.852405187,0.387529178,"nochange",3576.81,3280.94,2905.94,3510.87,1881.34,2930.41,1.186580347,1.088427656,0.964024171,1.164705238,0.624120675,0.972141913,"nucleus","K15690",null,null,"GO:0000209 protein polyubiquitination; GO:0000288 nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0001775 cell activation; GO:0001776 leukocyte homeostasis; GO:0001782 B cell homeostasis; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002260 lymphocyte homeostasis; GO:0002263 cell activation involved in immune response; GO:0002285 lymphocyte activation involved in immune response; GO:0002286 T cell activation involved in immune response; GO:0002287 alpha-beta T cell activation involved in immune response; GO:0002292 T cell differentiation involved in immune response; GO:0002293 alpha-beta T cell differentiation involved in immune response; GO:0002294 CD4-positive"," alpha-beta T cell differentiation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0002634 regulation of germinal center formation; GO:0002635 negative regulation of germinal center formation; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002698 negative regulation of immune effector process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0002819 regulation of adaptive immune response; GO:0002820 negative regulation of adaptive immune response; GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006417 regulation of translation; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008340 determination of adult lifespan; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016567 protein ubiquitination; GO:0017148 negative regulation of translation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019538 protein metabolic process; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030217 T cell differentiation; GO:0030888 regulation of B cell proliferation; GO:0030889 negative regulation of B cell proliferation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032943 mononuclear cell proliferation; GO:0032944 regulation of mononuclear cell proliferation; GO:0032945 negative regulation of mononuclear cell proliferation; GO:0033962 P-body assembly; GO:0034097 response to cytokine; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035710 CD4-positive"," alpha-beta T cell activation; GO:0036211 protein modification process; GO:0042093 T-helper cell differentiation; GO:0042098 T cell proliferation; GO:0042110 T cell activation; GO:0042127 regulation of cell population proliferation; GO:0042129 regulation of T cell proliferation; GO:0042130 negative regulation of T cell proliferation; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0043029 T cell homeostasis; GO:0043170 macromolecule metabolic process; GO:0043367 CD4-positive"," alpha-beta T cell differentiation; GO:0043370 regulation of CD4-positive"," alpha-beta T cell differentiation; GO:0043371 negative regulation of CD4-positive"," alpha-beta T cell differentiation; GO:0043412 macromolecule modification; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0045321 leukocyte activation; GO:0045580 regulation of T cell differentiation; GO:0045581 negative regulation of T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045620 negative regulation of lymphocyte differentiation; GO:0045622 regulation of T-helper cell differentiation; GO:0045623 negative regulation of T-helper cell differentiation; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046006 regulation of activated T cell proliferation; GO:0046007 negative regulation of activated T cell proliferation; GO:0046483 heterocycle metabolic process; GO:0046631 alpha-beta T cell activation; GO:0046632 alpha-beta T cell differentiation; GO:0046634 regulation of alpha-beta T cell activation; GO:0046636 negative regulation of alpha-beta T cell activation; GO:0046637 regulation of alpha-beta T cell differentiation; GO:0046639 negative regulation of alpha-beta T cell differentiation; GO:0046649 lymphocyte activation; GO:0046651 lymphocyte proliferation; GO:0046700 heterocycle catabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048535 lymph node development; GO:0048536 spleen development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048872 homeostasis of number of cells; GO:0050670 regulation of lymphocyte proliferation; GO:0050672 negative regulation of lymphocyte proliferation; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050779 RNA destabilization; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050854 regulation of antigen receptor-mediated signaling pathway; GO:0050856 regulation of T cell receptor signaling pathway; GO:0050863 regulation of T cell activation; GO:0050864 regulation of B cell activation; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050868 negative regulation of T cell activation; GO:0050869 negative regulation of B cell activation; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051250 negative regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061013 regulation of mRNA catabolic process; GO:0061014 positive regulation of mRNA catabolic process; GO:0061157 mRNA destabilization; GO:0061158 3'-UTR-mediated mRNA destabilization; GO:0061470 T follicular helper cell differentiation; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070555 response to interleukin-1; GO:0070647 protein modification by small protein conjugation or removal; GO:0070661 leukocyte proliferation; GO:0070663 regulation of leukocyte proliferation; GO:0070664 negative regulation of leukocyte proliferation; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901224 positive regulation of NIK/NF-kappaB signaling; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process; GO:1902105 regulation of leukocyte differentiation; GO:1902106 negative regulation of leukocyte differentiation; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903038 negative regulation of leukocyte cell-cell adhesion; GO:1903311 regulation of mRNA metabolic process; GO:1903313 positive regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000316 regulation of T-helper 17 type immune response; GO:2000317 negative regulation of T-helper 17 type immune response; GO:2000319 regulation of T-helper 17 cell differentiation; GO:2000320 negative regulation of T-helper 17 cell differentiation; GO:2000514 regulation of CD4-positive"," alpha-beta T cell activation; GO:2000515 negative regulation of CD4-positive"," alpha-beta T cell activation; GO:2000628 regulation of miRNA metabolic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0009986 cell surface; GO:0010494 cytoplasmic stress granule; GO:0016020 membrane; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:1990904 ribonucleoprotein complex;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003723 RNA binding; GO:0003725 double-stranded RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0035198 miRNA binding; GO:0035613 RNA stem-loop binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0061980 regulatory RNA binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF13445; PF18386","PF13445 RING-type zinc-finger; PF18386 Roquin II domain","O","KOG3161","Predicted E3 ubiquitin ligase"]
["Q5VU43","Myomegalin OS=Homo sapiens OX=9606 GN=PDE4DIP PE=1 SV=3","PDE4DIP",1.081736562,0.283294855,"nochange",4199.5,3562.79,4363.74,4224.86,4559.19,4333.12,0.998169804,0.846831622,1.037207644,1.004197566,1.083663719,1.029929644,"nucleus","K16549",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0009987 cellular process; GO:0010638 positive regulation of organelle organization; GO:0010968 regulation of microtubule nucleation; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0030953 astral microtubule organization; GO:0031110 regulation of microtubule polymerization or depolymerization; GO:0031112 positive regulation of microtubule polymerization or depolymerization; GO:0031113 regulation of microtubule polymerization; GO:0031116 positive regulation of microtubule polymerization; GO:0031122 cytoplasmic microtubule organization; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032886 regulation of microtubule-based process; GO:0033043 regulation of organelle organization; GO:0043254 regulation of protein-containing complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0071840 cellular component organization or biogenesis; GO:0090063 positive regulation of microtubule nucleation; GO:0097435 supramolecular fiber organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1903358 regulation of Golgi organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0030016 myofibril; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding;","PF06758","PF06758 Olduvai domain",{"$nulls":3},"WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782",{"$nulls":3},"MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["Q5VVJ2","Deubiquitinase MYSM1 OS=Homo sapiens OX=9606 GN=MYSM1 PE=1 SV=1","MYSM1",0.637089687,0.001260496,"down",5612.65,5321,4768.99,3482.64,3164.93,3356.42,1.310008352,1.241936419,1.113095727,0.812858006,0.738703595,0.783397902,"nucleus","K11865",null,null,"GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016578 histone deubiquitination; GO:0016579 protein deubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0030334 regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0035520 monoubiquitinated protein deubiquitination; GO:0035521 monoubiquitinated histone deubiquitination; GO:0035522 monoubiquitinated histone H2A deubiquitination; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0042634 regulation of hair cycle; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043473 pigmentation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045682 regulation of epidermis development; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051797 regulation of hair follicle development; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904888 cranial skeletal system development; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003824 catalytic activity; GO:0004843 thiol-dependent deubiquitinase; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0008237 metallopeptidase activity; GO:0016787 hydrolase activity; GO:0019783 ubiquitin-like protein-specific protease activity; GO:0042393 histone binding; GO:0044877 protein-containing complex binding; GO:0101005 deubiquitinase activity; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity;","PF00249; PF04433","PF00249 Myb-like DNA-binding domain; PF04433 SWIRM domain","O","KOG1555","26S proteasome regulatory complex"," subunit RPN11",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689901 Metalloprotease DUBs;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689901;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q63ZY3","KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KANK2 PE=1 SV=1","KANK2",0.705484838,0.032386036,"nochange",4504.05,4711.96,4072.44,3169.57,3643.33,2561.9,1.19242827,1.247471567,1.07816134,0.83913031,0.964556275,0.678252237,"nucleus","K22808",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007346 regulation of mitotic cell cycle; GO:0008285 negative regulation of cell population proliferation; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032104 regulation of response to extracellular stimulus; GO:0032105 negative regulation of response to extracellular stimulus; GO:0032107 regulation of response to nutrient levels; GO:0032108 negative regulation of response to nutrient levels; GO:0032231 regulation of actin filament bundle assembly; GO:0032232 negative regulation of actin filament bundle assembly; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway; GO:0033146 regulation of intracellular estrogen receptor signaling pathway; GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway; GO:0042127 regulation of cell population proliferation; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0044087 regulation of cellular component biogenesis; GO:0045786 negative regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051497 negative regulation of stress fiber assembly; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070562 regulation of vitamin D receptor signaling pathway; GO:0070563 negative regulation of vitamin D receptor signaling pathway; GO:0080090 regulation of primary metabolic process; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"R","KOG0514","Ankyrin repeat protein"]
["Q68DK2","Zinc finger FYVE domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZFYVE26 PE=1 SV=3","ZFYVE26",0.585452939,0.009239376,"down",2878.83,3203.38,3064.93,2193.25,1515.48,1646.49,1.191046147,1.325320844,1.268040512,0.907404036,0.626993124,0.681195336,"nucleus","K19027",null,null,"GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0032465 regulation of cytokinesis; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051302 regulation of cell division; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0030496 midbody; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0005488 binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:1901981 phosphatidylinositol phosphate binding;","PF01363","PF01363 FYVE zinc finger","R","KOG1811","Predicted Zn2+-binding protein"," contains FYVE domain"]
["Q6AWC2","Protein WWC2 OS=Homo sapiens OX=9606 GN=WWC2 PE=1 SV=2","WWC2",0.586865382,0.003418994,"down",5975.9,5185.25,6432.51,3383.27,3126.81,3815.03,1.284275776,1.114357832,1.382405457,0.727095785,0.671980177,0.819884973,"nucleus",{"$nulls":3},"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001745 compound eye morphogenesis; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006928 movement of cell or subcellular component; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007221 positive regulation of transcription of Notch receptor target; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008285 negative regulation of cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014013 regulation of gliogenesis; GO:0014014 negative regulation of gliogenesis; GO:0016477 cell migration; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030010 establishment of cell polarity; GO:0030154 cell differentiation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0035329 hippo signaling; GO:0035330 regulation of hippo signaling; GO:0035331 negative regulation of hippo signaling; GO:0035332 positive regulation of hippo signaling; GO:0035556 intracellular signal transduction; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046620 regulation of organ growth; GO:0046621 negative regulation of organ growth; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060251 regulation of glial cell proliferation; GO:0060253 negative regulation of glial cell proliferation; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090596 sensory organ morphogenesis; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005938 cell cortex; GO:0009898 cytoplasmic side of plasma membrane; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0030054 cell junction; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0032587 ruffle membrane; GO:0032991 protein-containing complex; GO:0036375 Kibra-Ex-Mer complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045177 apical part of cell; GO:0045179 apical cortex; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098590 plasma membrane region; GO:0098592 cytoplasmic side of apical plasma membrane; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0140110 transcription regulator activity;","PF00397","PF00397 WW domain","R","KOG3209","WW domain-containing protein"]
["Q6IBS0","Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2","TWF2",1.08085376,0.092879032,"nochange",70046.7,76204.5,72775.1,75105.9,79717.6,81911.9,0.922149009,1.003215057,0.95806778,0.988752236,1.049464227,1.078351691,"cytoplasm","K08870",null,null,"GO:0000003 reproduction; GO:0001101 response to acid chemical; GO:0001558 regulation of cell growth; GO:0001667 ameboidal-type cell migration; GO:0001932 regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007274 neuromuscular synaptic transmission; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0008154 actin polymerization or depolymerization; GO:0008361 regulation of cell size; GO:0008407 chaeta morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010591 regulation of lamellipodium assembly; GO:0010592 positive regulation of lamellipodium assembly; GO:0010631 epithelial cell migration; GO:0010639 negative regulation of organelle organization; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016319 mushroom body development; GO:0016477 cell migration; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022411 cellular component disassembly; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030042 actin filament depolymerization; GO:0030154 cell differentiation; GO:0030307 positive regulation of cell growth; GO:0030516 regulation of axon extension; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030834 regulation of actin filament depolymerization; GO:0030835 negative regulation of actin filament depolymerization; GO:0030837 negative regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032507 maintenance of protein location in cell; GO:0032526 response to retinoic acid; GO:0032530 regulation of microvillus organization; GO:0032532 regulation of microvillus length; GO:0032535 regulation of cellular component size; GO:0032536 regulation of cell projection size; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0035556 intracellular signal transduction; GO:0036465 synaptic vesicle recycling; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042989 sequestering of actin monomers; GO:0043242 negative regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0043538 regulation of actin phosphorylation; GO:0043933 protein-containing complex organization; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045185 maintenance of protein location; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045773 positive regulation of axon extension; GO:0045927 positive regulation of growth; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048488 synaptic vesicle endocytosis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051016 barbed-end actin filament capping; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051261 protein depolymerization; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051651 maintenance of location in cell; GO:0051674 localization of cell; GO:0051693 actin filament capping; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0061387 regulation of extent of cell growth; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071300 cellular response to retinoic acid; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071396 cellular response to lipid; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901879 regulation of protein depolymerization; GO:1901880 negative regulation of protein depolymerization; GO:1902743 regulation of lamellipodium organization; GO:1902745 positive regulation of lamellipodium organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030016 myofibril; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030175 filopodium; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031252 cell leading edge; GO:0032420 stereocilium; GO:0032421 stereocilium bundle; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0000166 nucleotide binding; GO:0003779 actin binding; GO:0003785 actin monomer binding; GO:0005080 protein kinase C binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008092 cytoskeletal protein binding; GO:0008289 lipid binding; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035091 phosphatidylinositol binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00241","PF00241 Cofilin/tropomyosin-type actin-binding protein","W","KOG1747","Protein tyrosine kinase 9/actin monomer-binding protein",{"$nulls":3},"R-HSA-9659379 Sensory processing of sound;R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea;R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea;R-HSA-9709957 Sensory Perception","https://reactome.org/PathwayBrowser/#/R-HSA-9659379;https://reactome.org/PathwayBrowser/#/R-HSA-9662360;https://reactome.org/PathwayBrowser/#/R-HSA-9662361;https://reactome.org/PathwayBrowser/#/R-HSA-9709957"]
["Q6IE81","Protein Jade-1 OS=Homo sapiens OX=9606 GN=JADE1 PE=1 SV=1","JADE1",1.001219917,0.957890917,"nochange",2257.82,2542.71,2527.84,2434.29,2525.45,2377.57,0.923715777,1.040269527,1.034185936,0.995912907,1.033208143,0.972707709,"nucleus","K11347",null,null,"GO:0001558 regulation of cell growth; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0006325 chromatin organization; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010948 negative regulation of cell cycle process; GO:0012501 programmed cell death; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0030178 negative regulation of Wnt signaling pathway; GO:0030182 neuron differentiation; GO:0030308 negative regulation of cell growth; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0042051 compound eye photoreceptor development; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043543 protein acylation; GO:0043966 histone H3 acetylation; GO:0043967 histone H4 acetylation; GO:0043981 histone H4-K5 acetylation; GO:0043982 histone H4-K8 acetylation; GO:0043983 histone H4-K12 acetylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045786 negative regulation of cell cycle; GO:0045926 negative regulation of growth; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0090596 sensory organ morphogenesis; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2001141 regulation of RNA biosynthetic process;","GO:0000123 histone acetyltransferase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031248 protein acetyltransferase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0036064 ciliary basal body; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0120025 plasma membrane bounded cell projection; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0140110 transcription regulator activity;","PF13832","PF13832 PHD-zinc-finger like domain","R","KOG0954","PHD finger protein",{"$nulls":3},"R-HSA-3214847 HATs acetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214847;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["Q6MZP7","Protein lin-54 homolog OS=Homo sapiens OX=9606 GN=LIN54 PE=1 SV=3","LIN54",0.810645749,0.301727603,"nochange",6622.03,5893.11,7441.37,6247.69,6364.96,3565.01,1.099573617,0.978538043,1.235623234,1.037415278,1.056887705,0.591962123,"nucleus","K21776","LIN54; protein lin-54","hsa04218 Cellular senescence","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006277 DNA amplification; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007307 eggshell chorion gene amplification; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010927 cellular component assembly involved in morphogenesis; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030317 flagellated sperm motility; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0040011 locomotion; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044703 multi-organism reproductive process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051674 localization of cell; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097722 sperm motility; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000793 condensed chromosome; GO:0000794 condensed nuclear chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0017053 transcription repressor complex; GO:0030849 autosome; GO:0031523 Myb complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070176 DRM complex; GO:0090571 RNA polymerase II transcription repressor complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF03638","PF03638 Tesmin/TSO1-like CXC domain"," cysteine-rich domain","P","KOG1171","Metallothionein-like protein",{"$nulls":3},"R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex;R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1;R-HSA-1538133 G0 and Early G1;R-HSA-156711 Polo-like kinase mediated events;R-HSA-1640170 Cell Cycle;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-453279 Mitotic G1 phase and G1/S transition;R-HSA-69202 Cyclin E associated events during G1/S transition ;R-HSA-69205 G1/S-Specific Transcription;R-HSA-69206 G1/S Transition;R-HSA-69242 S Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry","https://reactome.org/PathwayBrowser/#/R-HSA-1362277;https://reactome.org/PathwayBrowser/#/R-HSA-1362300;https://reactome.org/PathwayBrowser/#/R-HSA-1538133;https://reactome.org/PathwayBrowser/#/R-HSA-156711;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-453274;https://reactome.org/PathwayBrowser/#/R-HSA-453279;https://reactome.org/PathwayBrowser/#/R-HSA-69202;https://reactome.org/PathwayBrowser/#/R-HSA-69205;https://reactome.org/PathwayBrowser/#/R-HSA-69206;https://reactome.org/PathwayBrowser/#/R-HSA-69242;https://reactome.org/PathwayBrowser/#/R-HSA-69275;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-69656"]
["Q6P1Q9","tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3","METTL2B",1.69911568,0.279129594,"nochange",468.884,2342.06,780.177,2198.92,2802.86,1099.95,0.290245254,1.449765399,0.482939643,1.36115989,1.735006553,0.680883261,"cytoplasm","K24974",null,null,"GO:0001510 RNA methylation; GO:0002946 tRNA C5-cytosine methylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006400 tRNA modification; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0030488 tRNA methylation; GO:0032259 methylation; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;",null,"GO:0003824 catalytic activity; GO:0008168 methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008175 tRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016427 tRNA (cytosine) methyltransferase activity; GO:0016428 tRNA (cytosine-5-)-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF13489","PF13489 Methyltransferase domain","R","KOG2361","Predicted methyltransferase"]
["Q6P3W7","SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1","SCYL2",1.140649979,0.012952873,"nochange",25480.2,26624.1,25836.7,28432,31229.3,29242.1,0.916310047,0.957446579,0.929130375,1.022461647,1.123057172,1.05159418,"cytoplasm","K17541",null,null,"GO:0000003 reproduction; GO:0002090 regulation of receptor internalization; GO:0002092 positive regulation of receptor internalization; GO:0006810 transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0008152 metabolic process; GO:0008333 endosome to lysosome transport; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016055 Wnt signaling pathway; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030100 regulation of endocytosis; GO:0030111 regulation of Wnt signaling pathway; GO:0030178 negative regulation of Wnt signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031623 receptor internalization; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0043112 receptor metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0045807 positive regulation of endocytosis; GO:0046907 intracellular transport; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060070 canonical Wnt signaling pathway; GO:0060255 regulation of macromolecule metabolic process; GO:0060627 regulation of vesicle-mediated transport; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090090 negative regulation of canonical Wnt signaling pathway; GO:0098657 import into cell; GO:0198738 cell-cell signaling by wnt; GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling; GO:2000286 receptor internalization involved in canonical Wnt signaling pathway; GO:2000369 regulation of clathrin-dependent endocytosis; GO:2000370 positive regulation of clathrin-dependent endocytosis;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding;","PF00069","PF00069 Protein kinase domain","T","KOG2137","Protein kinase"]
["Q6P6C2","RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2","ALKBH5",1.096872589,0.179736286,"nochange",31619.2,30094.8,31490.9,30614.3,35216.3,36403.3,0.970714106,0.923914801,0.966775277,0.939863528,1.081145607,1.117586682,"plasma membrane","K10767",null,null,"GO:0000003 reproduction; GO:0001666 response to hypoxia; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006304 DNA modification; GO:0006307 DNA dealkylation involved in DNA repair; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009628 response to abiotic stimulus; GO:0009987 cellular process; GO:0010467 gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035510 DNA dealkylation; GO:0035513 oxidative RNA demethylation; GO:0035553 oxidative single-stranded RNA demethylation; GO:0036293 response to decreased oxygen levels; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048232 male gamete generation; GO:0048609 multicellular organismal reproductive process; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0070482 response to oxygen levels; GO:0070727 cellular macromolecule localization; GO:0070988 demethylation; GO:0070989 oxidative demethylation; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0032451 demethylase activity; GO:0035515 oxidative RNA demethylase activity; GO:0051213 dioxygenase activity; GO:0140098 catalytic activity"," acting on RNA;",null,null,"S","KOG4176","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-73894 DNA Repair;R-HSA-73942 DNA Damage Reversal;R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases","https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-73942;https://reactome.org/PathwayBrowser/#/R-HSA-73943"]
["Q6PJI9","GATOR complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2","WDR59",0.668581817,0.179030214,"nochange",1299.17,1528.56,2169.79,1582.99,762.849,995.412,0.934792429,1.099845529,1.561230066,1.139009573,0.548893116,0.716229286,"nucleus","K20409","WDR59; SEA/GATOR complex protein SEA3/WDR59","hsa04150 mTOR signaling pathway","GO:0006950 response to stress; GO:0007154 cell communication; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032006 regulation of TOR signaling; GO:0032008 positive regulation of TOR signaling; GO:0033554 cellular response to stress; GO:0034198 cellular response to amino acid starvation; GO:0042594 response to starvation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0071496 cellular response to external stimulus; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1990928 response to amino acid starvation;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0032991 protein-containing complex; GO:0035859 Seh1-associated complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0061700 GATOR2 complex; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane;",null,"PF17120","PF17120 RING/Ubox like zinc-binding domain","S","KOG0309","Conserved WD40 repeat-containing protein",{"$nulls":3},"R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9639288 Amino acids regulate mTORC1;R-HSA-9711097 Cellular response to starvation","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9639288;https://reactome.org/PathwayBrowser/#/R-HSA-9711097"]
["Q6UB28","Methionine aminopeptidase 1D"," mitochondrial OS=Homo sapiens OX=9606 GN=METAP1D PE=1 SV=1","METAP1D",0.699237204,0.085714592,"nochange",5169.97,7626.78,4766.26,4349.15,4008.86,3922.7,1.039408626,1.533343698,0.958243811,0.874384963,0.805970569,0.788648332,"mitochondria","K01265",null,null,"GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0018193 peptidyl-amino acid modification; GO:0018206 peptidyl-methionine modification; GO:0019538 protein metabolic process; GO:0031365 N-terminal protein amino acid modification; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004177 aminopeptidase activity; GO:0008233 peptidase activity; GO:0008235 metalloexopeptidase activity; GO:0008237 metallopeptidase activity; GO:0008238 exopeptidase activity; GO:0016787 hydrolase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00557","PF00557 Metallopeptidase family M24","O","KOG2738","Putative methionine aminopeptidase"]
["Q6UVK1","Chondroitin sulfate proteoglycan 4 OS=Homo sapiens OX=9606 GN=CSPG4 PE=1 SV=2","CSPG4",1.196762518,0.139305324,"nochange",3437.34,3603.19,3251.42,4859.88,3673.46,3783.68,0.912206085,0.956219589,0.862866376,1.289721734,0.97486794,1.004118277,"extracellular","K08115",null,null,"GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006022 aminoglycan metabolic process; GO:0006023 aminoglycan biosynthetic process; GO:0006024 glycosaminoglycan biosynthetic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006029 proteoglycan metabolic process; GO:0006082 organic acid metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007517 muscle organ development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008347 glial cell migration; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010226 response to lithium ion; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016053 organic acid biosynthetic process; GO:0016203 muscle attachment; GO:0016322 neuron remodeling; GO:0016477 cell migration; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030166 proteoglycan biosynthetic process; GO:0030182 neuron differentiation; GO:0030203 glycosaminoglycan metabolic process; GO:0030204 chondroitin sulfate metabolic process; GO:0030205 dermatan sulfate metabolic process; GO:0030206 chondroitin sulfate biosynthetic process; GO:0030207 chondroitin sulfate catabolic process; GO:0030208 dermatan sulfate biosynthetic process; GO:0030239 myofibril assembly; GO:0031032 actomyosin structure organization; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032787 monocarboxylic acid metabolic process; GO:0032989 cellular component morphogenesis; GO:0033674 positive regulation of kinase activity; GO:0034645 cellular macromolecule biosynthetic process; GO:0035556 intracellular signal transduction; GO:0040011 locomotion; GO:0042063 gliogenesis; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042551 neuron maturation; GO:0042692 muscle cell differentiation; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043436 oxoacid metabolic process; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044272 sulfur compound biosynthetic process; GO:0044273 sulfur compound catabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045214 sarcomere organization; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046394 carboxylic acid biosynthetic process; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050650 chondroitin sulfate proteoglycan biosynthetic process; GO:0050651 dermatan sulfate proteoglycan biosynthetic process; GO:0050654 chondroitin sulfate proteoglycan metabolic process; GO:0050655 dermatan sulfate proteoglycan metabolic process; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060491 regulation of cell projection assembly; GO:0060538 skeletal muscle organ development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071695 anatomical structure maturation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072330 monocarboxylic acid biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0097435 supramolecular fiber organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903510 mucopolysaccharide metabolic process; GO:2000026 regulation of multicellular organismal development;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005794 Golgi apparatus; GO:0005796 Golgi lumen; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0005912 adherens junction; GO:0005927 muscle tendon junction; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0030018 Z disc; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031674 I band; GO:0031974 membrane-enclosed lumen; GO:0042995 cell projection; GO:0043034 costamere; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0051286 cell tip; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0005488 binding; GO:0005515 protein binding; GO:0005518 collagen binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0044877 protein-containing complex binding;","PF00054; PF02210; PF16184","PF00054 Laminin G domain; PF02210 Laminin G domain; PF16184 Cadherin-like","R","KOG3597","Proteoglycan","WP2431 SPINAL CORD INJURY","http://www.wikipathways.org/instance/WP2431_r117177",null,"R-HSA-1430728 Metabolism;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism;R-HSA-1643685 Disease;R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism;R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis;R-HSA-2022870 Chondroitin sulfate biosynthesis;R-HSA-2022923 Dermatan sulfate biosynthesis;R-HSA-2024101 CS/DS degradation;R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism;R-HSA-3560783 Defective B4GALT7 causes EDS"," progeroid type;R-HSA-3560801 Defective B3GAT3 causes JDSSDHD;R-HSA-3595172 Defective CHST3 causes SEDCJD;R-HSA-3595174 Defective CHST14 causes EDS"," musculocontractural type;R-HSA-3595177 Defective CHSY1 causes TPBS;R-HSA-3781865 Diseases of glycosylation;R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1;R-HSA-5668914 Diseases of metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-1638091;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1793185;https://reactome.org/PathwayBrowser/#/R-HSA-1971475;https://reactome.org/PathwayBrowser/#/R-HSA-2022870;https://reactome.org/PathwayBrowser/#/R-HSA-2022923;https://reactome.org/PathwayBrowser/#/R-HSA-2024101;https://reactome.org/PathwayBrowser/#/R-HSA-3560782;https://reactome.org/PathwayBrowser/#/R-HSA-3560783;https://reactome.org/PathwayBrowser/#/R-HSA-3560801;https://reactome.org/PathwayBrowser/#/R-HSA-3595172;https://reactome.org/PathwayBrowser/#/R-HSA-3595174;https://reactome.org/PathwayBrowser/#/R-HSA-3595177;https://reactome.org/PathwayBrowser/#/R-HSA-3781865;https://reactome.org/PathwayBrowser/#/R-HSA-4420332;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["Q6VMQ6","Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3","ATF7IP",0.977321091,0.804837282,"nochange",7306.55,8244.71,8677.86,8675.64,8737.62,6266.37,0.915058314,1.032551674,1.086798549,1.086520521,1.094282777,0.784788165,"nucleus","K25802",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006304 DNA modification; GO:0006305 DNA alkylation; GO:0006306 DNA methylation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032259 methylation; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044728 DNA methylation or demethylation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060260 regulation of transcription initiation from RNA polymerase II promoter; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly; GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly; GO:1901360 organic cyclic compound metabolic process; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905269 positive regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000142 regulation of DNA-templated transcription"," initiation; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0140110 transcription regulator activity;","PF16794","PF16794 Fibronectin-III type domain",{"$nulls":5},"Transcription factor","R-HSA-3214841 PKMTs methylate histone lysines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214841;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["Q6Y7W6","GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1","GIGYF2",0.991921404,0.520757038,"nochange",60442.5,61307.6,62687.9,61154.8,60484.2,61309,0.987122536,1.001251,1.023793503,0.998755532,0.987803564,1.001273865,"nucleus","K18730",null,null,"GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0001894 tissue homeostasis; GO:0003008 system process; GO:0006417 regulation of translation; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0007631 feeding behavior; GO:0008152 metabolic process; GO:0008344 adult locomotory behavior; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010948 negative regulation of cell cycle process; GO:0016441 posttranscriptional gene silencing; GO:0017148 negative regulation of translation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0021510 spinal cord development; GO:0021515 cell differentiation in spinal cord; GO:0021517 ventral spinal cord development; GO:0021522 spinal cord motor neuron differentiation; GO:0021953 central nervous system neuron differentiation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030534 adult behavior; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0035264 multicellular organism growth; GO:0040007 growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045786 negative regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046716 muscle cell cellular homeostasis; GO:0048009 insulin-like growth factor receptor signaling pathway; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048589 developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0048872 homeostasis of number of cells; GO:0048873 homeostasis of number of cells within a tissue; GO:0050779 RNA destabilization; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050879 multicellular organismal movement; GO:0050881 musculoskeletal movement; GO:0050885 neuromuscular process controlling balance; GO:0050896 response to stimulus; GO:0050905 neuromuscular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0061013 regulation of mRNA catabolic process; GO:0061014 positive regulation of mRNA catabolic process; GO:0061157 mRNA destabilization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070050 neuron cellular homeostasis; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903047 mitotic cell cycle process; GO:1903311 regulation of mRNA metabolic process; GO:1903313 positive regulation of mRNA metabolic process; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0010494 cytoplasmic stress granule; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030425 dendrite; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043204 perikaryon; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0120025 plasma membrane bounded cell projection; GO:1990635 proximal dendrite; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0070064 proline-rich region binding;","PF02213","PF02213 GYF domain","R","KOG1862","GYF domain containing proteins","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782"]
["Q6ZRY4","RNA-binding protein with multiple splicing 2 OS=Homo sapiens OX=9606 GN=RBPMS2 PE=1 SV=1","RBPMS2",0.792786738,0.058153351,"nochange",26009,20698.1,26948.9,19965.2,19864.3,18564,1.181784104,0.940470051,1.224490816,0.907168903,0.902584258,0.843501869,"cytoplasm","K25091",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002682 regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007044 cell-substrate junction assembly; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007517 muscle organ development; GO:0007610 behavior; GO:0007638 mechanosensory behavior; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0008380 RNA splicing; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0022611 dormancy process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030510 regulation of BMP signaling pathway; GO:0030514 negative regulation of BMP signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031581 hemidesmosome assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035206 regulation of hemocyte proliferation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048546 digestive tract morphogenesis; GO:0048557 embryonic digestive tract morphogenesis; GO:0048562 embryonic organ morphogenesis; GO:0048565 digestive tract development; GO:0048566 embryonic digestive tract development; GO:0048568 embryonic organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048644 muscle organ morphogenesis; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051150 regulation of smooth muscle cell differentiation; GO:0051151 negative regulation of smooth muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0055123 digestive system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060390 regulation of SMAD protein signal transduction; GO:0060391 positive regulation of SMAD protein signal transduction; GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090288 negative regulation of cellular response to growth factor stimulus; GO:0090304 nucleic acid metabolic process; GO:0098916 anterograde trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:1901360 organic cyclic compound metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005685 U1 snRNP; GO:0005737 cytoplasm; GO:0030532 small nuclear ribonucleoprotein complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008143 poly(A) binding; GO:0017069 snRNA binding; GO:0030619 U1 snRNA binding; GO:0035613 RNA stem-loop binding; GO:0035614 snRNA stem-loop binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","R","KOG1457","RNA binding protein (contains RRM repeats)"]
["Q70UQ0","Inhibitor of nuclear factor kappa-B kinase-interacting protein OS=Homo sapiens OX=9606 GN=IKBIP PE=1 SV=1","IKBIP",0.884016743,0.018280974,"nochange",9469.65,9230.11,10121.9,8621.87,8221.03,8635.93,1.046360723,1.019892454,1.118431896,0.952684221,0.908392908,0.954237798,"plasma membrane",{"$nulls":3},"GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0010165 response to X-ray; GO:0010212 response to ionizing radiation; GO:0050896 response to stimulus;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":9},"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-166166 MyD88-independent TLR4 cascade ;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation  ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-9020702 Interleukin-1 signaling;R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling ;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-9758274 Regulation of NF-kappa B signaling;R-HSA-975871 MyD88 cascade initiated on plasma membrane","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-166016;https://reactome.org/PathwayBrowser/#/R-HSA-166058;https://reactome.org/PathwayBrowser/#/R-HSA-166166;https://reactome.org/PathwayBrowser/#/R-HSA-168138;https://reactome.org/PathwayBrowser/#/R-HSA-168142;https://reactome.org/PathwayBrowser/#/R-HSA-168164;https://reactome.org/PathwayBrowser/#/R-HSA-168176;https://reactome.org/PathwayBrowser/#/R-HSA-168179;https://reactome.org/PathwayBrowser/#/R-HSA-168181;https://reactome.org/PathwayBrowser/#/R-HSA-168188;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168898;https://reactome.org/PathwayBrowser/#/R-HSA-181438;https://reactome.org/PathwayBrowser/#/R-HSA-445989;https://reactome.org/PathwayBrowser/#/R-HSA-446652;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-9020702;https://reactome.org/PathwayBrowser/#/R-HSA-937061;https://reactome.org/PathwayBrowser/#/R-HSA-975138;https://reactome.org/PathwayBrowser/#/R-HSA-975155;https://reactome.org/PathwayBrowser/#/R-HSA-9758274;https://reactome.org/PathwayBrowser/#/R-HSA-975871"]
["Q75N03","E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1","CBLL1",1.322059711,3.942152E-3,"up",7153.32,7704.47,6607.36,9755.6,9290.88,9331.73,0.861096042,0.92744189,0.795374951,1.174351007,1.118409353,1.123326758,"nucleus","K15685",null,null,"GO:0001510 RNA methylation; GO:0001667 ameboidal-type cell migration; GO:0001700 embryonic development via the syncytial blastoderm; GO:0002009 morphogenesis of an epithelium; GO:0003002 regionalization; GO:0006139 nucleobase-containing compound metabolic process; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007155 cell adhesion; GO:0007162 negative regulation of cell adhesion; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007391 dorsal closure; GO:0007424 open tracheal system development; GO:0007427 epithelial cell migration"," open tracheal system; GO:0007494 midgut development; GO:0008152 metabolic process; GO:0008258 head involution; GO:0009451 RNA modification; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0016556 mRNA modification; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0022610 biological adhesion; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0032259 methylation; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035282 segmentation; GO:0035295 tube development; GO:0035635 entry of bacterium into host cell; GO:0036211 protein modification process; GO:0040003 chitin-based cuticle development; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042335 cuticle development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044409 entry into host; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045807 positive regulation of endocytosis; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048565 digestive tract development; GO:0048598 embryonic morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051674 localization of cell; GO:0051701 biological process involved in interaction with host; GO:0055123 digestive system development; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080009 mRNA methylation; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090304 nucleic acid metabolic process; GO:0097435 supramolecular fiber organization; GO:0098609 cell-cell adhesion; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0036396 RNA N6-methyladenosine methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045293 mRNA editing complex; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0045296 cadherin binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0050839 cell adhesion molecule binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF18408","PF18408 C2H2 Hakai zinc finger domain","O","KOG2932","E3 ubiquitin ligase involved in ubiquitination of E-cadherin complex",{"$nulls":3},"R-HSA-1643685 Disease;R-HSA-5663205 Infectious disease;R-HSA-8876384 Listeria monocytogenes entry into host cells;R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-8876384;https://reactome.org/PathwayBrowser/#/R-HSA-8876493"]
["Q7L1T6","Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1","CYB5R4",0.960109974,0.553121424,"nochange",17736.1,16206.3,19524.6,17509.1,17570.3,16254.8,1.015413946,0.927830979,1.117807811,1.002417911,1.005921688,0.930607665,"mitochondria","K00326","CYB5R; cytochrome-b5 reductase [EC:1.6.2.2]","hsa00520 Amino sugar and nucleotide sugar metabolism","GO:0002790 peptide secretion; GO:0003032 detection of oxygen; GO:0006091 generation of precursor metabolites and energy; GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006739 NADP metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006778 porphyrin-containing compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006801 superoxide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009117 nucleotide metabolic process; GO:0009306 protein secretion; GO:0009593 detection of chemical stimulus; GO:0009628 response to abiotic stimulus; GO:0009914 hormone transport; GO:0009987 cellular process; GO:0010817 regulation of hormone levels; GO:0015031 protein transport; GO:0015701 bicarbonate transport; GO:0015711 organic anion transport; GO:0015833 peptide transport; GO:0019362 pyridine nucleotide metabolic process; GO:0019637 organophosphate metabolic process; GO:0023052 signaling; GO:0023061 signal release; GO:0030072 peptide hormone secretion; GO:0030073 insulin secretion; GO:0030154 cell differentiation; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033013 tetrapyrrole metabolic process; GO:0033036 macromolecule localization; GO:0033500 carbohydrate homeostasis; GO:0034641 cellular nitrogen compound metabolic process; GO:0042168 heme metabolic process; GO:0042221 response to chemical; GO:0042440 pigment metabolic process; GO:0042592 homeostatic process; GO:0042593 glucose homeostasis; GO:0042886 amide transport; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0046677 response to antibiotic; GO:0046879 hormone secretion; GO:0046903 secretion; GO:0048468 cell development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051606 detection of stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070482 response to oxygen levels; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0072524 pyridine-containing compound metabolic process; GO:0072593 reactive oxygen species metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0003958 NADPH-hemoprotein reductase activity; GO:0004128 cytochrome-b5 reductase activity"," acting on NAD(P)H; GO:0005488 binding; GO:0016174 NAD(P)H oxidase H2O2-forming activity; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0016653 oxidoreductase activity"," acting on NAD(P)H"," heme protein as acceptor; GO:0020037 heme binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046906 tetrapyrrole binding; GO:0050660 flavin adenine dinucleotide binding; GO:0050664 oxidoreductase activity"," acting on NAD(P)H"," oxygen as acceptor; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00173; PF04969; PF00970; PF00175","PF00173 Cytochrome b5-like Heme/Steroid binding domain; PF04969 CS domain; PF00970 Oxidoreductase FAD-binding domain; PF00175 Oxidoreductase NAD-binding domain ","C","KOG0536","Flavohemoprotein b5+b5R","WP43 OXIDATION BY CYTOCHROME P450","http://www.wikipathways.org/instance/WP43_r119227",null,"R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen;R-HSA-1480926 O2/CO2 exchange in erythrocytes;R-HSA-382551 Transport of small molecules","https://reactome.org/PathwayBrowser/#/R-HSA-1237044;https://reactome.org/PathwayBrowser/#/R-HSA-1480926;https://reactome.org/PathwayBrowser/#/R-HSA-382551"]
["Q7L3B6","Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1","CDC37L1",1.270078965,0.052029446,"nochange",3029.8,3225.03,2422.41,3529.66,3670.98,3820.14,0.922874482,0.982341372,0.737864009,1.075131409,1.11817736,1.163611368,"cytoplasm",{"$nulls":3},"GO:0002576 platelet degranulation; GO:0006457 protein folding; GO:0006810 transport; GO:0006887 exocytosis; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0031647 regulation of protein stability; GO:0032940 secretion by cell; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0050821 protein stabilization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031089 platelet dense granule lumen; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0042827 platelet dense granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0031072 heat shock protein binding; GO:0051082 unfolded protein binding; GO:0051087 chaperone binding;","PF08565","PF08565 Cdc37 Hsp90 binding domain","D","KOG2260","Cell division cycle 37 protein"," CDC37",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005"]
["Q7LFL8","CXXC-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=CXXC5 PE=1 SV=1","CXXC5",1.176976113,0.434878936,"nochange",4680.16,4856.56,2822.01,5024.79,3878.2,5642.94,1.043721051,1.083059961,0.629335587,1.120576881,0.864876196,1.258430324,"nucleus","K22760",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF02008","PF02008 CXXC zinc finger domain",{"$nulls":3},"WP5094 OREXIN RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP5094_r120665",null,"R-HSA-162582 Signal Transduction;R-HSA-8939211 ESR-mediated signaling;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9018519 Estrogen-dependent gene expression","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9018519"]
["Q7RTV0","PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1","PHF5A",1.170877041,0.066113977,"nochange",38409.5,38097,44056.8,49943.2,47865.8,43355.8,0.880520662,0.873356739,1.009982497,1.144925593,1.097302124,0.993912385,"extracellular","K12834","PHF5A; PHD finger-like domain-containing protein 5A","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005686 U2 snRNP; GO:0005689 U12-type spliceosomal complex; GO:0005737 cytoplasm; GO:0016363 nuclear matrix; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071011 precatalytic spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003700 DNA-binding transcription factor activity; GO:0003723 RNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"S","KOG1705","Uncharacterized conserved protein"," contains CXXC motifs","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160","Transcription factor","R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["Q7Z406","Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2","MYH14",1.182596583,0.03862315,"nochange",32317.4,29690.9,31318.2,35951.4,34143.3,40272.9,0.951939207,0.874573196,0.922506837,1.058982072,1.005722797,1.186275891,"nucleus","K10352","MYH9s; myosin heavy chain 9/10/11/14","hsa04810 Regulation of actin cytoskeleton; hsa04270 Vascular smooth muscle contraction; hsa05130 Pathogenic Escherichia coli infection; hsa04530 Tight junction","GO:0001508 action potential; GO:0003008 system process; GO:0003009 skeletal muscle contraction; GO:0003012 muscle system process; GO:0006928 movement of cell or subcellular component; GO:0006936 muscle contraction; GO:0006941 striated muscle contraction; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0007610 behavior; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0014706 striated muscle tissue development; GO:0016043 cellular component organization; GO:0019226 transmission of nerve impulse; GO:0019228 neuronal action potential; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030048 actin filament-based movement; GO:0031032 actomyosin structure organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0035637 multicellular organismal signaling; GO:0042391 regulation of membrane potential; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050877 nervous system process; GO:0050879 multicellular organismal movement; GO:0050881 musculoskeletal movement; GO:0050954 sensory perception of mechanical stimulus; GO:0060537 muscle tissue development; GO:0060538 skeletal muscle organ development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070584 mitochondrion morphogenesis; GO:0071625 vocalization behavior; GO:0071840 cellular component organization or biogenesis;","GO:0001725 stress fiber; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005903 brush border; GO:0015629 actin cytoskeleton; GO:0016459 myosin complex; GO:0016460 myosin II complex; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0032432 actin filament bundle; GO:0032982 myosin filament; GO:0032991 protein-containing complex; GO:0042641 actomyosin; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0097513 myosin II filament; GO:0097517 contractile actin filament bundle; GO:0098862 cluster of actin-based cell projections; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0000146 microfilament motor activity; GO:0000166 nucleotide binding; GO:0003774 cytoskeletal motor activity; GO:0003779 actin binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008092 cytoskeletal protein binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF02736; PF00063","PF02736 Myosin N-terminal SH3-like domain; PF00063 Myosin head (motor domain)","Z","KOG0161","Myosin class II heavy chain",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2682334 EPH-Ephrin signaling;R-HSA-373755 Semaphorin interactions;R-HSA-3928663 EPHA-mediated growth cone collapse;R-HSA-400685 Sema4D in semaphorin signaling;R-HSA-416572 Sema4D induced cell migration and growth-cone collapse;R-HSA-422475 Axon guidance;R-HSA-5625740 RHO GTPases activate PKNs;R-HSA-5625900 RHO GTPases activate CIT;R-HSA-5627117 RHO GTPases Activate ROCKs;R-HSA-5627123 RHO GTPases activate PAKs;R-HSA-9675108 Nervous system development;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2682334;https://reactome.org/PathwayBrowser/#/R-HSA-373755;https://reactome.org/PathwayBrowser/#/R-HSA-3928663;https://reactome.org/PathwayBrowser/#/R-HSA-400685;https://reactome.org/PathwayBrowser/#/R-HSA-416572;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5625740;https://reactome.org/PathwayBrowser/#/R-HSA-5625900;https://reactome.org/PathwayBrowser/#/R-HSA-5627117;https://reactome.org/PathwayBrowser/#/R-HSA-5627123;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q7Z5H3","Rho GTPase-activating protein 22 OS=Homo sapiens OX=9606 GN=ARHGAP22 PE=1 SV=1","ARHGAP22",0.478077497,0.004235436,"down",11253.6,10718.6,12986.4,5717.83,4442.94,6552.15,1.306746928,1.244623731,1.507956414,0.663943697,0.515905861,0.76082337,"nucleus","K20642",null,null,"GO:0009966 regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0023051 regulation of signaling; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0048583 regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:1902531 regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005912 adherens junction; GO:0005925 focal adhesion; GO:0030054 cell junction; GO:0030055 cell-substrate junction; GO:0042995 cell projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0070161 anchoring junction;","GO:0005096 GTPase activator activity; GO:0008047 enzyme activator activity; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00169; PF00620","PF00169 PH domain; PF00620 RhoGAP domain","T","KOG4270","GTPase-activator protein",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q7Z6M1","Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1","RABEPK",0.631378186,2.596138E-3,"down",11714.4,13182.8,11870.7,8138.57,6868.13,8207.75,1.1717847,1.318667908,1.187419299,0.81409648,0.687015097,0.821016516,"cytoplasm","nucleus","K20285",null,null,"GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006904 vesicle docking involved in exocytosis; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0022406 membrane docking; GO:0032940 secretion by cell; GO:0046903 secretion; GO:0048278 vesicle docking; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0098657 import into cell; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;",{"$nulls":3},"R","KOG0379","Kelch repeat-containing proteins",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442","MYC TARGETS V2","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2"]
["Q7Z7K6","Centromere protein V OS=Homo sapiens OX=9606 GN=CENPV PE=1 SV=1","CENPV",1.362697202,3.115076E-3,"up",8940.47,10401.8,10282.8,13473.5,13570.3,13326.2,0.766379975,0.891645654,0.881444936,1.15495277,1.163250497,1.142326167,"mitochondria",{"$nulls":3},"GO:0001667 ameboidal-type cell migration; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006338 chromatin remodeling; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0009987 cellular process; GO:0010564 regulation of cell cycle process; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0022607 cellular component assembly; GO:0031055 chromatin remodeling at centromere; GO:0031497 chromatin assembly; GO:0031507 heterochromatin assembly; GO:0031508 pericentric heterochromatin assembly; GO:0032465 regulation of cytokinesis; GO:0032467 positive regulation of cytokinesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034508 centromere complex assembly; GO:0040011 locomotion; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045787 positive regulation of cell cycle; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051276 chromosome organization; GO:0051302 regulation of cell division; GO:0051674 localization of cell; GO:0051726 regulation of cell cycle; GO:0051781 positive regulation of cell division; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0070828 heterochromatin organization; GO:0071103 DNA conformation change; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090068 positive regulation of cell cycle process;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005819 spindle; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0051233 spindle midzone; GO:0098687 chromosomal region;",null,"PF04828","PF04828 Glutathione-dependent formaldehyde-activating enzyme","S","KOG4192","Uncharacterized conserved protein"]
["Q86SF2","N-acetylgalactosaminyltransferase 7 OS=Homo sapiens OX=9606 GN=GALNT7 PE=1 SV=1","GALNT7",0.682101511,0.000567727,"down",20334.1,20918.9,20127.6,14747.5,13010,14110.3,1.181660926,1.215644988,1.169660741,0.857010859,0.756040772,0.819981714,"endoplasmic reticulum","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]","hsa00514 Other types of O-glycan biosynthesis; hsa00512 Mucin type O-glycan biosynthesis; hsa01100 Metabolic pathways","GO:0005975 carbohydrate metabolic process; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009311 oligosaccharide metabolic process; GO:0009312 oligosaccharide biosynthetic process; GO:0009987 cellular process; GO:0016051 carbohydrate biosynthetic process; GO:0016266 O-glycan processing; GO:0019538 protein metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity; GO:0008194 UDP-glycosyltransferase activity; GO:0008376 acetylgalactosaminyltransferase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00652","PF00652 Ricin-type beta-trefoil lectin domain","O","KOG3737","Predicted polypeptide N-acetylgalactosaminyltransferase",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5173105 O-linked glycosylation;R-HSA-597592 Post-translational protein modification;R-HSA-913709 O-linked glycosylation of mucins","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5173105;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-913709"]
["Q86U86","Protein polybromo-1 OS=Homo sapiens OX=9606 GN=PBRM1 PE=1 SV=1","PBRM1",0.829422492,{"v":8.13115e-05,"d":"8.13E-05"},"down",22257,22748.9,21949,18364.5,18663.3,18506.1,1.090238454,1.114333719,1.075151361,0.89956796,0.914204401,0.906504105,"nucleus","K11757","PBRM1; protein polybromo-1","hsa05225 Hepatocellular carcinoma","GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000278 mitotic cell cycle; GO:0001568 blood vessel development; GO:0001570 vasculogenesis; GO:0001890 placenta development; GO:0001944 vasculature development; GO:0001974 blood vessel remodeling; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002165 instar larval or pupal development; GO:0003006 developmental process involved in reproduction; GO:0003007 heart morphogenesis; GO:0003158 endothelium development; GO:0003348 cardiac endothelial cell differentiation; GO:0003349 epicardium-derived cardiac endothelial cell differentiation; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007304 chorion-containing eggshell formation; GO:0007305 vitelline membrane formation involved in chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007444 imaginal disc development; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007507 heart development; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008285 negative regulation of cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010927 cellular component assembly involved in morphogenesis; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030198 extracellular matrix organization; GO:0030703 eggshell formation; GO:0030704 vitelline membrane formation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0035051 cardiocyte differentiation; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035218 leg disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035803 egg coat formation; GO:0035886 vascular associated smooth muscle cell differentiation; GO:0040029 regulation of gene expression"," epigenetic; GO:0042127 regulation of cell population proliferation; GO:0042692 muscle cell differentiation; GO:0043062 extracellular structure organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045446 endothelial cell differentiation; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048771 tissue remodeling; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051145 smooth muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0055001 muscle cell development; GO:0055006 cardiac cell development; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060947 cardiac vascular smooth muscle cell differentiation; GO:0060948 cardiac vascular smooth muscle cell development; GO:0060976 coronary vasculature development; GO:0060977 coronary vasculature morphogenesis; GO:0060979 vasculogenesis involved in coronary vascular morphogenesis; GO:0061061 muscle structure development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0085029 extracellular matrix assembly; GO:0097084 vascular associated smooth muscle cell development; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905268 negative regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0016586 RSC-type complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035060 brahma complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0098687 chromosomal region; GO:1902494 catalytic complex; GO:1904949 ATPase complex;","GO:0003682 chromatin binding; GO:0005488 binding;","PF00439; PF01426; PF00505","PF00439 Bromodomain; PF01426 BAH domain; PF00505 HMG (high mobility group) box","BK","KOG1827","Chromatin remodeling complex RSC"," subunit RSC1/Polybromo and related proteins","WP4018 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS","http://www.wikipathways.org/instance/WP4018_r117168","Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-3214858 RMTs methylate histone arginines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3214858;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8939243"]
["Q86UU1","Pleckstrin homology-like domain family B member 1 OS=Homo sapiens OX=9606 GN=PHLDB1 PE=1 SV=1","PHLDB1",0.969834636,0.984544309,"nochange",4736.44,2785.61,4804.67,4362.38,"NA",3607.54,1.166803964,0.686224419,1.183612164,1.074655707,"NA",0.888703746,"nucleus","K23794",null,null,"GO:0010470 regulation of gastrulation; GO:0010717 regulation of epithelial to mesenchymal transition; GO:0022603 regulation of anatomical structure morphogenesis; GO:0032886 regulation of microtubule-based process; GO:0033043 regulation of organelle organization; GO:0040019 positive regulation of embryonic development; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045595 regulation of cell differentiation; GO:0045995 regulation of embryonic development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051493 regulation of cytoskeleton organization; GO:0065007 biological regulation; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0110011 regulation of basement membrane organization; GO:1903053 regulation of extracellular matrix organization; GO:1903055 positive regulation of extracellular matrix organization; GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis; GO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005938 cell cortex; GO:0045178 basal part of cell; GO:0045180 basal cortex; GO:0071944 cell periphery; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region;",null,"PF00169","PF00169 PH domain",{"$nulls":8},"ADIPOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS"]
["Q86VP1","Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2","TAX1BP1",1.120991339,0.306851464,"nochange",3405.91,2567.11,2919.6,3595.2,3415.41,2957.94,1.08346725,0.816633327,0.928765289,1.143683027,1.086489332,0.940961775,"cytoplasm","K21347","TAX1BP1; Tax1-binding protein 1","hsa04137 Mitophagy - animal","GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0006355 regulation of transcription"," DNA-templated; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010646 regulation of cell communication; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010941 regulation of cell death; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0032479 regulation of type I interferon production; GO:0032480 negative regulation of type I interferon production; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0044092 negative regulation of molecular function; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0060759 regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0032182 ubiquitin-like protein binding; GO:0043130 ubiquitin binding;","PF17751; PF18112","PF17751 SKICH domain; PF18112 Autophagy receptor zinc finger-C2H2 domain",{"$nulls":6},"R-HSA-162582 Signal Transduction;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta;R-HSA-5357905 Regulation of TNFR1 signaling;R-HSA-73887 Death Receptor Signalling;R-HSA-75893 TNF signaling;R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-168928;https://reactome.org/PathwayBrowser/#/R-HSA-5357905;https://reactome.org/PathwayBrowser/#/R-HSA-73887;https://reactome.org/PathwayBrowser/#/R-HSA-75893;https://reactome.org/PathwayBrowser/#/R-HSA-936440"]
["Q86X55","Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3","CARM1",0.9068773,0.0922799,"nochange",41727.7,43424.8,37740.2,37498.7,37733.1,36216.8,1.068382739,1.111834747,0.966288059,0.96010477,0.966106273,0.927283411,"nucleus","K05931","CARM1; type I protein arginine methyltransferase [EC:2.1.1.319]","hsa01522 Endocrine resistance","GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0001501 skeletal system development; GO:0003420 regulation of growth plate cartilage chondrocyte proliferation; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006977 DNA damage response"," signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007568 aging; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008284 positive regulation of cell population proliferation; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010830 regulation of myotube differentiation; GO:0010948 negative regulation of cell cycle process; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016043 cellular component organization; GO:0016202 regulation of striated muscle tissue development; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0018193 peptidyl-amino acid modification; GO:0018195 peptidyl-arginine modification; GO:0018216 peptidyl-arginine methylation; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019919 peptidyl-arginine methylation"," to asymmetrical-dimethyl arginine; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030520 intracellular estrogen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031570 DNA integrity checkpoint signaling; GO:0031571 mitotic G1 DNA damage checkpoint signaling; GO:0032091 negative regulation of protein binding; GO:0032259 methylation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032870 cellular response to hormone stimulus; GO:0033036 macromolecule localization; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033146 regulation of intracellular estrogen receptor signaling pathway; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034502 protein localization to chromosome; GO:0034613 cellular protein localization; GO:0034969 histone arginine methylation; GO:0034970 histone H3-R2 methylation; GO:0034971 histone H3-R17 methylation; GO:0035246 peptidyl-arginine N-methylation; GO:0035247 peptidyl-arginine omega-N-methylation; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042770 signal transduction in response to DNA damage; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043401 steroid hormone mediated signaling pathway; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044819 mitotic G1/S transition checkpoint signaling; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045598 regulation of fat cell differentiation; GO:0045600 positive regulation of fat cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046620 regulation of organ growth; GO:0046683 response to organophosphorus; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048634 regulation of muscle organ development; GO:0048638 regulation of developmental growth; GO:0048641 regulation of skeletal muscle tissue development; GO:0048699 generation of neurons; GO:0048705 skeletal system morphogenesis; GO:0048731 system development; GO:0048742 regulation of skeletal muscle fiber development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051147 regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051591 response to cAMP; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060348 bone development; GO:0060349 bone morphogenesis; GO:0060350 endochondral bone morphogenesis; GO:0061035 regulation of cartilage development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071168 protein localization to chromatin; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901564 organonitrogen compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901861 regulation of muscle tissue development; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902415 regulation of mRNA binding; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903010 regulation of bone development; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905214 regulation of RNA binding; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2000171 negative regulation of dendrite development; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0090575 RNA polymerase II transcription regulator complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008469 histone-arginine N-methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016273 arginine N-methyltransferase activity; GO:0016274 protein-arginine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0030374 nuclear receptor coactivator activity; GO:0035241 protein-arginine omega-N monomethyltransferase activity; GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity; GO:0035642 histone methyltransferase activity (H3-R17 specific); GO:0042054 histone methyltransferase activity; GO:0042393 histone binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0070577 lysine-acetylated histone binding; GO:0097159 organic cyclic compound binding; GO:0140030 modification-dependent protein binding; GO:0140033 acetylation-dependent protein binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF11531","PF11531 Coactivator-associated arginine methyltransferase 1 N terminal","OK","KOG1500","Protein arginine N-methyltransferase CARM1","WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY;WP4947 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS","http://www.wikipathways.org/instance/WP138_r120688;http://www.wikipathways.org/instance/WP4947_r118070","Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-1368082 RORA activates gene expression;R-HSA-1368108 BMAL1:CLOCK","NPAS2 activates circadian gene expression;R-HSA-1430728 Metabolism;R-HSA-1592230 Mitochondrial biogenesis;R-HSA-162582 Signal Transduction;R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF);R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-1989781 PPARA activates gene expression;R-HSA-212436 Generic Transcription Pathway;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis;R-HSA-2262752 Cellular responses to stress;R-HSA-2426168 Activation of gene expression by SREBF (SREBP);R-HSA-3214858 RMTs methylate histone arginines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-381340 Transcriptional regulation of white adipocyte differentiation;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-400253 Circadian Clock;R-HSA-4839726 Chromatin organization;R-HSA-556833 Metabolism of lipids;R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes;R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8939211 ESR-mediated signaling;R-HSA-8953897 Cellular responses to stimuli;R-HSA-8957322 Metabolism of steroids;R-HSA-9006931 Signaling by Nuclear Receptors;R-HSA-9018519 Estrogen-dependent gene expression;R-HSA-9707564 Cytoprotection by HMOX1;R-HSA-9707616 Heme signaling;R-HSA-9711123 Cellular response to chemical stress","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1368082;https://reactome.org/PathwayBrowser/#/R-HSA-1368108;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1655829;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-1989781;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2151201;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2426168;https://reactome.org/PathwayBrowser/#/R-HSA-3214858;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-381340;https://reactome.org/PathwayBrowser/#/R-HSA-400206;https://reactome.org/PathwayBrowser/#/R-HSA-400253;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-6791312;https://reactome.org/PathwayBrowser/#/R-HSA-6804114;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8939211;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-8957322;https://reactome.org/PathwayBrowser/#/R-HSA-9006931;https://reactome.org/PathwayBrowser/#/R-HSA-9018519;https://reactome.org/PathwayBrowser/#/R-HSA-9707564;https://reactome.org/PathwayBrowser/#/R-HSA-9707616;https://reactome.org/PathwayBrowser/#/R-HSA-9711123"]
["Q86XK2","F-box only protein 11 OS=Homo sapiens OX=9606 GN=FBXO11 PE=1 SV=3","FBXO11",1.381577386,0.00100171,"up",3988.95,4146.94,3998.11,5985.3,5430.9,5347.86,0.828211306,0.8610142,0.830113163,1.242706258,1.127598185,1.110356889,"nucleus","K10297",null,null,"GO:0000003 reproduction; GO:0000209 protein polyubiquitination; GO:0001667 ameboidal-type cell migration; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007548 sex differentiation; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008078 mesodermal cell migration; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008406 gonad development; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0016567 protein ubiquitination; GO:0018193 peptidyl-amino acid modification; GO:0018195 peptidyl-arginine modification; GO:0018216 peptidyl-arginine methylation; GO:0018996 molting cycle"," collagen and cuticulin-based cuticle; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030163 protein catabolic process; GO:0031047 gene silencing by RNA; GO:0031048 heterochromatin assembly by small RNA; GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032259 methylation; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035246 peptidyl-arginine N-methylation; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0040034 regulation of development"," heterochronic; GO:0042303 molting cycle; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045137 development of primary sexual characteristics; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048608 reproductive structure development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050954 sensory perception of mechanical stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051674 localization of cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060966 regulation of gene silencing by RNA; GO:0061458 reproductive system development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0070922 small RNA loading onto RISC; GO:0070923 siRNA loading onto RISC involved in gene silencing by small RNA; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0019005 SCF ubiquitin ligase complex; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016273 arginine N-methyltransferase activity; GO:0016274 protein-arginine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0019787 ubiquitin-like protein transferase activity; GO:0140096 catalytic activity"," acting on a protein;","PF12937","PF12937 F-box-like","R","KOG1777","Putative Zn-finger protein",{"$nulls":3},"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8951664 Neddylation;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8951664;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["Q86YV9","BLOC-2 complex member HPS6 OS=Homo sapiens OX=9606 GN=HPS6 PE=1 SV=1","HPS6",0.705203752,0.003950841,"down",6850.28,7827.91,7844.79,5657.38,5253.97,4971.94,1.070181509,1.222911259,1.225548328,0.883821314,0.820798791,0.776738798,"mitochondria","K20192",null,null,"GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008104 protein localization; GO:0009611 response to wounding; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0030154 cell differentiation; GO:0030318 melanocyte differentiation; GO:0032418 lysosome localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042060 wound healing; GO:0043473 pigmentation; GO:0048066 developmental pigmentation; GO:0048869 cellular developmental process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0050931 pigment cell differentiation; GO:0051179 localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0016020 membrane; GO:0031082 BLOC complex; GO:0031084 BLOC-2 complex; GO:0031090 organelle membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0030742 GTP-dependent protein binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding;"]
["Q8IUF8","Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1","RIOX2",0.741881392,0.003578606,"down",17284.4,17685.3,15660.9,12111.6,12137.5,13312.8,1.175909516,1.203183944,1.065457947,0.823988434,0.825750489,0.905709669,"cytoplasm","nucleus","K21760",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006482 protein demethylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0008214 protein dealkylation; GO:0008283 cell population proliferation; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016577 histone demethylation; GO:0018193 peptidyl-amino acid modification; GO:0018195 peptidyl-arginine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0030961 peptidyl-arginine hydroxylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0034720 histone H3-K4 demethylation; GO:0036211 protein modification process; GO:0042127 regulation of cell population proliferation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070076 histone lysine demethylation; GO:0070544 histone H3-K36 demethylation; GO:0070988 demethylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0032451 demethylase activity; GO:0032452 histone demethylase activity; GO:0032453 histone H3-methyl-lysine-4 demethylase activity; GO:0042802 identical protein binding; GO:0051213 dioxygenase activity; GO:0051864 histone H3-methyl-lysine-36 demethylase activity; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity;",null,null,"S","KOG3706","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-3214842 HDMs demethylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214842;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["Q8IVH4","Methylmalonic aciduria type A protein"," mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1","MMAA",1.127990034,0.512810245,"nochange",6916.09,3109.94,5803.64,6158.24,5873.49,5823.98,1.231885762,0.55393883,1.033737485,1.096898417,1.046179084,1.037360422,"mitochondria","K07588",null,null,"GO:0006725 cellular aromatic compound metabolic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009235 cobalamin metabolic process; GO:0009987 cellular process; GO:0033013 tetrapyrrole metabolic process; GO:0044237 cellular metabolic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005525 GTP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046983 protein dimerization activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF03308","PF03308 Methylmalonyl Co-A mutase-associated GTPase MeaB",{"$nulls":3},"WP4271 VITAMIN B12 DISORDERS","http://www.wikipathways.org/instance/WP4271_r120408",null,"R-HSA-1430728 Metabolism;R-HSA-1643685 Disease;R-HSA-196741 Cobalamin (Cbl"," vitamin B12) transport and metabolism;R-HSA-196849 Metabolism of water-soluble vitamins and cofactors;R-HSA-196854 Metabolism of vitamins and cofactors;R-HSA-3296469 Defects in cobalamin (B12) metabolism;R-HSA-3296482 Defects in vitamin and cofactor metabolism;R-HSA-3359475 Defective MMAA causes MMA"," cblA type;R-HSA-3359478 Defective MUT causes MMAM;R-HSA-556833 Metabolism of lipids;R-HSA-5668914 Diseases of metabolism;R-HSA-71032 Propionyl-CoA catabolism;R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation;R-HSA-8978868 Fatty acid metabolism;R-HSA-9759218 Cobalamin (Cbl) metabolism;R-HSA-9759774 Diseases of mitochondrial beta oxidation;R-HSA-9759785 Diseases of propionyl-CoA catabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-196741;https://reactome.org/PathwayBrowser/#/R-HSA-196849;https://reactome.org/PathwayBrowser/#/R-HSA-196854;https://reactome.org/PathwayBrowser/#/R-HSA-3296469;https://reactome.org/PathwayBrowser/#/R-HSA-3296482;https://reactome.org/PathwayBrowser/#/R-HSA-3359475;https://reactome.org/PathwayBrowser/#/R-HSA-3359478;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-71032;https://reactome.org/PathwayBrowser/#/R-HSA-77289;https://reactome.org/PathwayBrowser/#/R-HSA-8978868;https://reactome.org/PathwayBrowser/#/R-HSA-9759218;https://reactome.org/PathwayBrowser/#/R-HSA-9759774;https://reactome.org/PathwayBrowser/#/R-HSA-9759785"]
["Q8IWC1","MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2","MAP7D3",1.086130932,0.48555482,"nochange",4405.89,5498.5,6325.9,6133.28,5265.28,6229.66,0.780759106,0.974378376,1.121000304,1.086866492,0.933049919,1.103945803,"nucleus","K16807",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0031109 microtubule polymerization or depolymerization; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0046785 microtubule polymerization; GO:0051258 protein polymerization; GO:0065003 protein-containing complex assembly; GO:0071840 cellular component organization or biogenesis; GO:0097435 supramolecular fiber organization;","GO:0005622 intracellular anatomical structure; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding;"]
["Q8IWT0","Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2","ZBTB8OS",0.516691179,{"v":5.3274e-05,"d":"5.33E-05"},"down",11441.5,12247.3,11191.3,6050.6,6231.12,5740.52,1.297655264,1.389046307,1.269278448,0.686238076,0.706712028,0.651069877,"cytoplasm","K24956",null,null,"GO:0000394 RNA splicing"," via endonucleolytic cleavage and ligation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006388 tRNA splicing"," via endonucleolytic cleavage and ligation; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010720 positive regulation of cell development; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016070 RNA metabolic process; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048679 regulation of axon regeneration; GO:0048680 positive regulation of axon regeneration; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060284 regulation of cell development; GO:0065007 biological regulation; GO:0070570 regulation of neuron projection regeneration; GO:0070572 positive regulation of neuron projection regeneration; GO:0071704 organic substance metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901360 organic cyclic compound metabolic process; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0072669 tRNA-splicing ligase complex;",null,"PF01951","PF01951 Archease protein family (MTH1598/TM1083)","S","KOG4528","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-6784531 tRNA processing in the nucleus;R-HSA-72306 tRNA processing;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6784531;https://reactome.org/PathwayBrowser/#/R-HSA-72306;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q8IXJ6","NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2","SIRT2",0.996347264,0.915399182,"nochange",7251.14,6902.1,6904.95,6671.21,7826.67,6483.39,1.034904825,0.985088771,0.985495532,0.952135446,1.117046223,0.925329203,"cytoplasm","K11412","SIRT2; NAD+-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]","hsa00760 Nicotinate and nicotinamide metabolism; hsa01100 Metabolic pathways","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000183 rDNA heterochromatin assembly; GO:0001666 response to hypoxia; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002237 response to molecule of bacterial origin; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0006091 generation of precursor metabolites and energy; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006471 protein ADP-ribosylation; GO:0006476 protein deacetylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006629 lipid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007088 regulation of mitotic nuclear division; GO:0007096 regulation of exit from mitosis; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007272 ensheathment of neurons; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007422 peripheral nervous system development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0008340 determination of adult lifespan; GO:0008366 axon ensheathment; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009060 aerobic respiration; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010001 glial cell differentiation; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010720 positive regulation of cell development; GO:0010721 negative regulation of cell development; GO:0010799 regulation of peptidyl-threonine phosphorylation; GO:0010801 negative regulation of peptidyl-threonine phosphorylation; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014013 regulation of gliogenesis; GO:0014014 negative regulation of gliogenesis; GO:0014037 Schwann cell differentiation; GO:0014044 Schwann cell development; GO:0014065 phosphatidylinositol 3-kinase signaling; GO:0014070 response to organic cyclic compound; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0016202 regulation of striated muscle tissue development; GO:0016570 histone modification; GO:0016575 histone deacetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0021782 glial cell development; GO:0022008 neurogenesis; GO:0022011 myelination in peripheral nervous system; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031641 regulation of myelination; GO:0031667 response to nutrient levels; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032292 peripheral nervous system axon ensheathment; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0033554 cellular response to stress; GO:0034599 cellular response to oxidative stress; GO:0034983 peptidyl-lysine deacetylation; GO:0035556 intracellular signal transduction; GO:0035601 protein deacylation; GO:0035728 response to hepatocyte growth factor; GO:0035729 cellular response to hepatocyte growth factor stimulus; GO:0036211 protein modification process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0040020 regulation of meiotic nuclear division; GO:0040029 regulation of gene expression"," epigenetic; GO:0042063 gliogenesis; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042552 myelination; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043254 regulation of protein-containing complex assembly; GO:0043388 positive regulation of DNA binding; GO:0043412 macromolecule modification; GO:0043491 protein kinase B signaling; GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044782 cilium organization; GO:0045333 cellular respiration; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045598 regulation of fat cell differentiation; GO:0045599 negative regulation of fat cell differentiation; GO:0045685 regulation of glial cell differentiation; GO:0045686 negative regulation of glial cell differentiation; GO:0045732 positive regulation of protein catabolic process; GO:0045787 positive regulation of cell cycle; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045836 positive regulation of meiotic nuclear division; GO:0045843 negative regulation of striated muscle tissue development; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048012 hepatocyte growth factor receptor signaling pathway; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048634 regulation of muscle organ development; GO:0048635 negative regulation of muscle organ development; GO:0048699 generation of neurons; GO:0048713 regulation of oligodendrocyte differentiation; GO:0048715 negative regulation of oligodendrocyte differentiation; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051101 regulation of DNA binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051302 regulation of cell division; GO:0051445 regulation of meiotic cell cycle; GO:0051446 positive regulation of meiotic cell cycle; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051775 response to redox state; GO:0051781 positive regulation of cell division; GO:0051783 regulation of nuclear division; GO:0051785 positive regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051983 regulation of chromosome segregation; GO:0051984 positive regulation of chromosome segregation; GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore; GO:0051988 regulation of attachment of spindle microtubules to kinetochore; GO:0060255 regulation of macromolecule metabolic process; GO:0060271 cilium assembly; GO:0060281 regulation of oocyte development; GO:0060282 positive regulation of oocyte development; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia; GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; GO:0061433 cellular response to caloric restriction; GO:0061771 response to caloric restriction; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070445 regulation of oligodendrocyte progenitor proliferation; GO:0070446 negative regulation of oligodendrocyte progenitor proliferation; GO:0070482 response to oxygen levels; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0070932 histone H3 deacetylation; GO:0070933 histone H4 deacetylation; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071407 cellular response to organic cyclic compound; GO:0071417 cellular response to organonitrogen compound; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071867 response to monoamine; GO:0071868 cellular response to monoamine stimulus; GO:0071869 response to catecholamine; GO:0071870 cellular response to catecholamine stimulus; GO:0071871 response to epinephrine; GO:0071872 cellular response to epinephrine stimulus; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090042 tubulin deacetylation; GO:0090068 positive regulation of cell cycle process; GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress; GO:0098732 macromolecule deacylation; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1900117 regulation of execution phase of apoptosis; GO:1900119 positive regulation of execution phase of apoptosis; GO:1900193 regulation of oocyte maturation; GO:1900195 positive regulation of oocyte maturation; GO:1900225 regulation of NLRP3 inflammasome complex assembly; GO:1900226 negative regulation of NLRP3 inflammasome complex assembly; GO:1900424 regulation of defense response to bacterium; GO:1900425 negative regulation of defense response to bacterium; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901861 regulation of muscle tissue development; GO:1901862 negative regulation of muscle tissue development; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903429 regulation of cell maturation; GO:1903431 positive regulation of cell maturation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905879 regulation of oogenesis; GO:1905881 positive regulation of oogenesis; GO:2000026 regulation of multicellular organismal development; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000378 negative regulation of reactive oxygen species metabolic process; GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000792 heterochromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005677 chromatin silencing complex; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005813 centrosome; GO:0005814 centriole; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0017053 transcription repressor complex; GO:0030054 cell junction; GO:0030424 axon; GO:0030496 midbody; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033010 paranodal junction; GO:0033270 paranode region of axon; GO:0035748 myelin sheath abaxonal region; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043204 perikaryon; GO:0043209 myelin sheath; GO:0043218 compact myelin; GO:0043219 lateral loop; GO:0043220 Schmidt-Lanterman incisure; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044224 juxtaparanode region of axon; GO:0044297 cell body; GO:0044304 main axon; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0072687 meiotic spindle; GO:0097386 glial cell projection; GO:0097456 terminal loop; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003824 catalytic activity; GO:0003950 NAD+ ADP-ribosyltransferase activity; GO:0004407 histone deacetylase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016763 pentosyltransferase activity; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016811 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in linear amides; GO:0017136 NAD-dependent histone deacetylase activity; GO:0019213 deacetylase activity; GO:0019899 enzyme binding; GO:0032182 ubiquitin-like protein binding; GO:0033558 protein deacetylase activity; GO:0034739 histone deacetylase activity (H4-K16 specific); GO:0034979 NAD-dependent protein deacetylase activity; GO:0035035 histone acetyltransferase binding; GO:0036094 small molecule binding; GO:0042826 histone deacetylase binding; GO:0042903 tubulin deacetylase activity; GO:0043130 ubiquitin binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific); GO:0051287 NAD binding; GO:0070403 NAD+ binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"BK","KOG2682","NAD-dependent histone deacetylases and class I sirtuins (SIR2 family)","WP3645 NAD BIOSYNTHETIC PATHWAYS;WP3644 NAD METABOLISM;WP5046 NAD METABOLISM IN ONCOGENEINDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTIONASSOCIATED SENESCENCE","http://www.wikipathways.org/instance/WP3645_r118940;http://www.wikipathways.org/instance/WP3644_r118983;http://www.wikipathways.org/instance/WP5046_r118987","Transcription factor","R-HSA-1640170 Cell Cycle;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation;R-HSA-2995410 Nuclear Envelope (NE) Reassembly;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-2995383;https://reactome.org/PathwayBrowser/#/R-HSA-2995410;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278","COAGULATION;MYOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COAGULATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYOGENESIS"]
["Q8IXM3","39S ribosomal protein L41"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1","MRPL41",1.004032311,0.907362309,"nochange",33649.8,33992.9,32176,34786.3,31945,33489.9,1.009292646,1.019583593,0.965087465,1.043380846,0.958158847,1.004496603,"extracellular","K17422",null,null,"GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000315 organellar large ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005762 mitochondrial large ribosomal subunit; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;",null,null,"J","KOG4756","Mitochondrial ribosomal protein L27",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q8IYB3","Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2","SRRM1",1.565523908,0.000439884,"up",18501.2,20322.7,18070.6,28390.5,30356.6,30322.6,0.760509769,0.8353842929999999,0.742809538,1.167019036,1.247837483,1.24643988,"nucleus","K13171","SRRM1; serine/arginine repetitive matrix protein 1","hsa03013 Nucleocytoplasmic transport; hsa03015 mRNA surveillance pathway","GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0001654 eye development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007275 multicellular organism development; GO:0007423 sensory organ development; GO:0007530 sex determination; GO:0007548 sex differentiation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018993 somatic sex determination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042752 regulation of circadian rhythm; GO:0042886 amide transport; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048608 reproductive structure development; GO:0048731 system development; GO:0048749 compound eye development; GO:0048806 genitalia development; GO:0048856 anatomical structure development; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903311 regulation of mRNA metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016363 nuclear matrix; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0035145 exon-exon junction complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"AR","KOG2146","Splicing coactivator SRm160/300"," subunit SRm160 (contains PWI domain)","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013418 RHOBTB2 GTPase cycle;R-HSA-9013422 RHOBTB1 GTPase cycle;R-HSA-9706574 RHOBTB GTPase Cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013418;https://reactome.org/PathwayBrowser/#/R-HSA-9013422;https://reactome.org/PathwayBrowser/#/R-HSA-9706574;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q8IYJ3","Synaptotagmin-like protein 1 OS=Homo sapiens OX=9606 GN=SYTL1 PE=1 SV=1","SYTL1",0.583709742,1.276711E-3,"down",9119.48,9779.6,9892.73,5974.89,4930.84,5900.33,1.199987631,1.286849583,1.301735805,0.786206461,0.648825044,0.776395476,"nucleus","K17598",null,null,"GO:0001505 regulation of neurotransmitter levels; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006906 vesicle fusion; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016079 synaptic vesicle exocytosis; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0017157 regulation of exocytosis; GO:0017158 regulation of calcium ion-dependent exocytosis; GO:0023052 signaling; GO:0023061 signal release; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048284 organelle fusion; GO:0048489 synaptic vesicle transport; GO:0048791 calcium ion-regulated exocytosis of neurotransmitter; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0090174 organelle membrane fusion; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:1903305 regulation of regulated secretory pathway; GO:1903530 regulation of secretion by cell;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005902 microvillus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030133 transport vesicle; GO:0031253 cell projection membrane; GO:0031410 cytoplasmic vesicle; GO:0031528 microvillus membrane; GO:0031982 vesicle; GO:0042470 melanosome; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0048770 pigment granule; GO:0070382 exocytic vesicle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0000149 SNARE binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005544 calcium-dependent phospholipid binding; GO:0008289 lipid binding; GO:0019905 syntaxin binding; GO:0030276 clathrin binding; GO:0042043 neurexin family protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding;","PF00168","PF00168 C2 domain","TU","KOG1028","Ca2+-dependent phospholipid-binding protein Synaptotagmin"," required for synaptic vesicle and secretory granule exocytosis","WP2291 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER","http://www.wikipathways.org/instance/WP2291_r117696",null,"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8854214 TBC/RABGAPs;R-HSA-9007101 Rab regulation of trafficking","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8854214;https://reactome.org/PathwayBrowser/#/R-HSA-9007101"]
["Q8IZP0","Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4","ABI1",0.986956842,0.787610086,"nochange",41181.5,43343.4,37838.1,39628.3,40588.4,40550.3,1.01628347,1.069635175,0.933774524,0.977953358,1.001646856,1.000706618,"cytoplasm","nucleus","K23649","ABI1; abl interactor 1","hsa05132 Salmonella infection; hsa05130 Pathogenic Escherichia coli infection","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001501 skeletal system development; GO:0001667 ameboidal-type cell migration; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001756 somitogenesis; GO:0001764 neuron migration; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007030 Golgi organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007423 sensory organ development; GO:0007517 muscle organ development; GO:0007528 neuromuscular junction development; GO:0008152 metabolic process; GO:0008154 actin polymerization or depolymerization; GO:0008285 negative regulation of cell population proliferation; GO:0008360 regulation of cell shape; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016192 vesicle-mediated transport; GO:0016203 muscle attachment; GO:0016310 phosphorylation; GO:0016333 morphogenesis of follicular epithelium; GO:0016334 establishment or maintenance of polarity of follicular epithelium; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0021953 central nervous system neuron differentiation; GO:0021954 central nervous system neuron development; GO:0021955 central nervous system neuron axonogenesis; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030032 lamellipodium assembly; GO:0030036 actin cytoskeleton organization; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030219 megakaryocyte differentiation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033627 cell adhesion mediated by integrin; GO:0033674 positive regulation of kinase activity; GO:0035282 segmentation; GO:0035855 megakaryocyte development; GO:0036211 protein modification process; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0040007 growth; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042247 establishment of planar polarity of follicular epithelium; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045807 positive regulation of endocytosis; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0048010 vascular endothelial growth factor receptor signaling pathway; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048846 axon extension involved in axon guidance; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051496 positive regulation of stress fiber assembly; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060100 positive regulation of phagocytosis"," engulfment; GO:0060255 regulation of macromolecule metabolic process; GO:0060269 centripetally migrating follicle cell migration; GO:0060348 bone development; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060538 skeletal muscle organ development; GO:0060560 developmental growth involved in morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0061053 somite development; GO:0061061 muscle structure development; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061098 positive regulation of protein tyrosine kinase activity; GO:0061515 myeloid cell development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072499 photoreceptor cell axon guidance; GO:0072673 lamellipodium morphogenesis; GO:0080090 regulation of primary metabolic process; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0097581 lamellipodium organization; GO:0098657 import into cell; GO:0098751 bone cell development; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901074 regulation of engulfment of apoptotic cell; GO:1901076 positive regulation of engulfment of apoptotic cell; GO:1901564 organonitrogen compound metabolic process; GO:1902284 neuron projection extension involved in neuron projection guidance; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1905153 regulation of membrane invagination; GO:1905155 positive regulation of membrane invagination; GO:1990138 neuron projection extension; GO:2000369 regulation of clathrin-dependent endocytosis; GO:2000370 positive regulation of clathrin-dependent endocytosis; GO:2000425 regulation of apoptotic cell clearance; GO:2000427 positive regulation of apoptotic cell clearance;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030175 filopodium; GO:0030424 axon; GO:0030425 dendrite; GO:0031209 SCAR complex; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031258 lamellipodium membrane; GO:0032433 filopodium tip; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0044297 cell body; GO:0045178 basal part of cell; GO:0045180 basal cortex; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0008134 transcription factor binding; GO:0017124 SH3 domain binding; GO:0019207 kinase regulator activity; GO:0019209 kinase activator activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0030295 protein kinase activator activity; GO:0030296 protein tyrosine kinase activator activity; GO:0044877 protein-containing complex binding; GO:0045296 cadherin binding; GO:0047485 protein N-terminus binding; GO:0050839 cell adhesion molecule binding; GO:0098772 molecular function regulator;","PF00018","PF00018 SH3 domain","TZ","KOG2546","Abl interactor ABI-1"," contains SH3 domain","WP437 EGFEGFR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP437_r120689",null,"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194138 Signaling by VEGF;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-4420097;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663213;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","ALLOGRAFT REJECTION;INFLAMMATORY RESPONSE;MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ALLOGRAFT_REJECTION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INFLAMMATORY_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q8N1G0","Zinc finger protein 687 OS=Homo sapiens OX=9606 GN=ZNF687 PE=1 SV=1","ZNF687",1.132667352,0.338763318,"nochange",6636.8,6105.93,8370.98,9036.6,7814.4,7063.81,0.884346188,0.813608353,1.115423736,1.204116857,1.041260073,0.941244793,"nucleus","K24375",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00096; PF16622","PF00096 Zinc finger"," C2H2 type; PF16622 zinc-finger C2H2-type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["Q8N2K1","Ubiquitin-conjugating enzyme E2 J2 OS=Homo sapiens OX=9606 GN=UBE2J2 PE=1 SV=3","UBE2J2",0.51691547,0.143084721,"nochange",5786.98,3046.04,5910.88,1995.45,"NA",3085.45,1.459530487,0.76823978,1.490779226,0.503271155,"NA",0.778179351,"cytoplasm","nucleus","K04554","UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]","hsa05022 Pathways of neurodegeneration - multiple diseases; hsa04120 Ubiquitin mediated proteolysis; hsa04141 Protein processing in endoplasmic reticulum; hsa05012 Parkinson disease","GO:0000209 protein polyubiquitination; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0032446 protein modification by small protein conjugation; GO:0033554 cellular response to stress; GO:0034976 response to endoplasmic reticulum stress; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0042221 response to chemical; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0050896 response to stimulus; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0061630 ubiquitin protein ligase activity; GO:0061631 ubiquitin conjugating enzyme activity; GO:0061650 ubiquitin-like protein conjugating enzyme activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00179","PF00179 Ubiquitin-conjugating enzyme","O","KOG0894","Ubiquitin-protein ligase","WP2371 PARKINSONS DISEASE PATHWAY;WP2359 PARKINUBIQUITIN PROTEASOMAL SYSTEM PATHWAY","http://www.wikipathways.org/instance/WP2371_r119919;http://www.wikipathways.org/instance/WP2359_r119918",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["Q8N4C8","Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2","MINK1",1.125953265,0.379807438,"nochange",2606.87,3094.52,3134.03,2876.4,3102.15,3969.72,0.832702201,0.988470317,1.00109084,0.918797105,0.990907537,1.268032,"nucleus","K04413",null,null,"GO:0000165 MAPK cascade; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001952 regulation of cell-matrix adhesion; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007254 JNK cascade; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010469 regulation of signaling receptor activity; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016358 dendrite development; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030033 microvillus assembly; GO:0030036 actin cytoskeleton organization; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030182 neuron differentiation; GO:0030217 T cell differentiation; GO:0030334 regulation of cell migration; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031532 actin cytoskeleton reorganization; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032409 regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032528 microvillus organization; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033077 T cell differentiation in thymus; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0042110 T cell activation; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043383 negative T cell selection; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045058 T cell selection; GO:0045060 negative thymic T cell selection; GO:0045061 thymic T cell selection; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046649 lymphocyte activation; GO:0046777 protein autophosphorylation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070050 neuron cellular homeostasis; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0098916 anterograde trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099601 regulation of neurotransmitter receptor activity; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900449 regulation of glutamate receptor signaling pathway; GO:1900744 regulation of p38MAPK cascade; GO:1900745 positive regulation of p38MAPK cascade; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1904062 regulation of cation transmembrane transport; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000311 regulation of AMPA receptor activity; GO:2001257 regulation of cation channel activity;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045177 apical part of cell; GO:0055037 recycling endosome; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004111 creatine kinase activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0008349 MAP kinase kinase kinase kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016775 phosphotransferase activity"," nitrogenous group as acceptor; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00069","PF00069 Protein kinase domain","T","KOG0587","Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases","WP3915 ANGIOPOIETINLIKE PROTEIN 8 REGULATORY PATHWAY;WP4537 HIPPOYAP SIGNALING PATHWAY;WP481 INSULIN SIGNALING;WP5087 MALIGNANT PLEURAL MESOTHELIOMA","http://www.wikipathways.org/instance/WP3915_r120659;http://www.wikipathways.org/instance/WP4537_r103300;http://www.wikipathways.org/instance/WP481_r120562;http://www.wikipathways.org/instance/WP5087_r120373",null,"R-HSA-2262752 Cellular responses to stress;R-HSA-2559580 Oxidative Stress Induced Senescence;R-HSA-2559583 Cellular Senescence;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2559580;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-8953897"]
["Q8N5A5","Zinc finger CCCH-type with G patch domain-containing protein OS=Homo sapiens OX=9606 GN=ZGPAT PE=1 SV=3","ZGPAT",1.570693066,0.013704281,"nochange",6394.92,4585.18,4927.33,9046.42,7923.71,8015.56,0.938287908,0.67275571,0.722957309,1.327326455,1.162598012,1.176074606,"nucleus",{"$nulls":3},"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006469 negative regulation of protein kinase activity; GO:0007175 negative regulation of epidermal growth factor-activated receptor activity; GO:0007176 regulation of epidermal growth factor-activated receptor activity; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030431 sleep; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0033673 negative regulation of kinase activity; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0045859 regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061099 negative regulation of protein tyrosine kinase activity; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0080090 regulation of primary metabolic process; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000272 negative regulation of signaling receptor activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF18044","PF18044 CCCH-type zinc finger","A","KOG2185","Predicted RNA-processing protein"," contains G-patch domain",null,null,"Transcription factor"]
["Q8N684","Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1","CPSF7",1.487142169,{"v":5.94696e-05,"d":"5.95E-05"},"up",27071.3,26989.2,25435.8,40134.9,38878.9,39208.5,0.821509964,0.819018545,0.771878822,1.217940042,1.179825267,1.189827361,"nucleus","K14398","CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7","hsa03250 Viral life cycle - HIV-1; hsa03015 mRNA surveillance pathway","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006353 DNA-templated transcription"," termination; GO:0006366 transcription by RNA polymerase II; GO:0006369 termination of RNA polymerase II transcription; GO:0006379 mRNA cleavage; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031440 regulation of mRNA 3'-end processing; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051262 protein tetramerization; GO:0051290 protein heterotetramerization; GO:0051291 protein heterooligomerization; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0097659 nucleic acid-templated transcription; GO:0098787 mRNA cleavage involved in mRNA processing; GO:0098789 pre-mRNA cleavage required for polyadenylation; GO:0110104 mRNA alternative polyadenylation; GO:1900363 regulation of mRNA polyadenylation; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1990120 messenger ribonucleoprotein complex assembly;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005847 mRNA cleavage and polyadenylation specificity factor complex; GO:0005849 mRNA cleavage factor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",null,"PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","A","KOG4849","mRNA cleavage factor I subunit/CPSF subunit",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75067 Processing of Capped Intronless Pre-mRNA;R-HSA-77595 Processing of Intronless Pre-mRNAs;R-HSA-8953854 Metabolism of RNA;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013422 RHOBTB1 GTPase cycle;R-HSA-9706574 RHOBTB GTPase Cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75067;https://reactome.org/PathwayBrowser/#/R-HSA-77595;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013422;https://reactome.org/PathwayBrowser/#/R-HSA-9706574;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q8N9F7","Lysophospholipase D GDPD1 OS=Homo sapiens OX=9606 GN=GDPD1 PE=1 SV=2","GDPD1",1.652809538,0.000467083,"up",16696.8,18533.3,19170.3,29788.6,31303.9,28821,0.694186769,0.770541161,0.797025096,1.238491926,1.301492095,1.198262953,"extracellular","K22387","GDPD1_3; lysophospholipase D [EC:3.1.4.39]","hsa00565 Ether lipid metabolism; hsa01100 Metabolic pathways","GO:0006066 alcohol metabolic process; GO:0006576 cellular biogenic amine metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009308 amine metabolic process; GO:0009987 cellular process; GO:0019637 organophosphate metabolic process; GO:0034308 primary alcohol metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042439 ethanolamine-containing compound metabolic process; GO:0044106 cellular amine metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0070291 N-acylethanolamine metabolic process; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901615 organic hydroxy compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0004620 phospholipase activity; GO:0004622 lysophospholipase activity; GO:0008081 phosphoric diester hydrolase activity; GO:0016298 lipase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0042578 phosphoric ester hydrolase activity; GO:0052689 carboxylic ester hydrolase activity;",null,null,"C","KOG2258","Glycerophosphoryl diester phosphodiesterase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-6814848 Glycerophospholipid catabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-6814848"]
["Q8NB14","Ubiquitin carboxyl-terminal hydrolase 38 OS=Homo sapiens OX=9606 GN=USP38 PE=1 SV=2","USP38",1.242627994,0.332822838,"nochange",4773.42,4207.98,5782.56,5407.51,4835.16,8103.44,0.865009346,0.762543842,1.047879391,0.979915174,0.876197483,1.468454763,"nucleus","K11854",null,null,"GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010941 regulation of cell death; GO:0016579 protein deubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045861 negative regulation of proteolysis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process;",null,"GO:0003824 catalytic activity; GO:0004843 thiol-dependent deubiquitinase; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0016787 hydrolase activity; GO:0019783 ubiquitin-like protein-specific protease activity; GO:0101005 deubiquitinase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG1864","Ubiquitin-specific protease"]
["Q8NBS9","Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2","TXNDC5",1.179202842,0.000226189,"up",98087.8,100530,98465.1,118943,114665,116713,0.909056618,0.931690402,0.912553353,1.102338123,1.06269054,1.081670963,"extracellular","K13984","TXNDC5; thioredoxin domain-containing protein 5","hsa04141 Protein processing in endoplasmic reticulum","GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006457 protein folding; GO:0006810 transport; GO:0006887 exocytosis; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006950 response to stress; GO:0006955 immune response; GO:0009987 cellular process; GO:0010941 regulation of cell death; GO:0016192 vesicle-mediated transport; GO:0030100 regulation of endocytosis; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0033554 cellular response to stress; GO:0034976 response to endoplasmic reticulum stress; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043277 apoptotic cell clearance; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045807 positive regulation of endocytosis; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0060548 negative regulation of cell death; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0098657 import into cell; GO:2000425 regulation of apoptotic cell clearance; GO:2000427 positive regulation of apoptotic cell clearance;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0042582 azurophil granule; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0003756 protein disulfide isomerase activity; GO:0003824 catalytic activity; GO:0016853 isomerase activity; GO:0016860 intramolecular oxidoreductase activity; GO:0016864 intramolecular oxidoreductase activity"," transposing S-S bonds; GO:0140096 catalytic activity"," acting on a protein;","PF00085","PF00085 Thioredoxin","O","KOG0191","Thioredoxin/protein disulfide isomerase","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432720;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["Q8NBZ0","INO80 complex subunit E OS=Homo sapiens OX=9606 GN=INO80E PE=1 SV=1","INO80E",1.238705067,0.055629525,"nochange",16593.1,13555.8,14492.8,18124.4,20305.5,16868,0.996187697,0.813839559,0.870093536,1.088121225,1.219066316,1.012691666,"nucleus","K11669",null,null,"GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016579 protein deubiquitination; GO:0019538 protein metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0031011 Ino80 complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033202 DNA helicase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0097346 INO80-type complex; GO:1902494 catalytic complex; GO:1904949 ATPase complex;",{"$nulls":6},"WP4949 16P112 PROXIMAL DELETION SYNDROME","http://www.wikipathways.org/instance/WP4949_r115778",null,"R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5696394 DNA Damage Recognition in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-597592 Post-translational protein modification;R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689603;https://reactome.org/PathwayBrowser/#/R-HSA-5696394;https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-5696399;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73894"]
["Q8ND76","Cyclin-Y OS=Homo sapiens OX=9606 GN=CCNY PE=1 SV=2","CCNY",1.004771185,0.995983224,"nochange",7233.66,5839.77,6204.8,5834.7,5786.34,7749.17,1.122993839,0.906598559,0.963267858,0.905811464,0.898303787,1.203024495,"nucleus",{"$nulls":3},"GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0000086 G2/M transition of mitotic cell cycle; GO:0000278 mitotic cell cycle; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0014041 regulation of neuron maturation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0030111 regulation of Wnt signaling pathway; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033674 positive regulation of kinase activity; GO:0040007 growth; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043085 positive regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044770 cell cycle phase transition; GO:0044772 mitotic cell cycle phase transition; GO:0044839 cell cycle G2/M phase transition; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity; GO:0045787 positive regulation of cell cycle; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048589 developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051964 negative regulation of synapse assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060828 regulation of canonical Wnt signaling pathway; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0099174 regulation of presynapse organization; GO:1903047 mitotic cell cycle process; GO:1903429 regulation of cell maturation; GO:1904029 regulation of cyclin-dependent protein kinase activity; GO:1904031 positive regulation of cyclin-dependent protein kinase activity; GO:1904799 regulation of neuron remodeling; GO:1905809 negative regulation of synapse organization; GO:2000026 regulation of multicellular organismal development; GO:2000331 regulation of terminal button organization;","GO:0000307 cyclin-dependent protein kinase holoenzyme complex; GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1902554 serine/threonine protein kinase complex; GO:1902911 protein kinase complex; GO:1990234 transferase complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity; GO:0019207 kinase regulator activity; GO:0019887 protein kinase regulator activity; GO:0030234 enzyme regulator activity; GO:0098772 molecular function regulator;","PF00134","PF00134 Cyclin"," N-terminal domain","R","KOG1675","Predicted cyclin"]
["Q8NE01","Metal transporter CNNM3 OS=Homo sapiens OX=9606 GN=CNNM3 PE=1 SV=1","CNNM3",1.129711742,0.0563265,"nochange",6918.29,6571.15,6496.8,8149.12,7143.93,7285.64,0.975209873,0.926276632,0.915796173,1.148709043,1.00701634,1.026991939,"plasma membrane","K16302",{"$nulls":5},"PF00571","PF00571 CBS domain","S","KOG2118","Predicted membrane protein"," contains two CBS domains"]
["Q8NEZ5","F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1","FBXO22",0.555724886,1.13356E-4,"down",21368.6,20523.8,20116.7,11879.4,11879.2,10701.4,1.329043186,1.276499936,1.251179911,0.73885213,0.738839691,0.665585146,"cytoplasm","K10302","FBXO22; F-box protein 22","hsa05132 Salmonella infection","GO:0000209 protein polyubiquitination; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0007154 cell communication; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010830 regulation of myotube differentiation; GO:0016202 regulation of striated muscle tissue development; GO:0016567 protein ubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032446 protein modification by small protein conjugation; GO:0033554 cellular response to stress; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0042594 response to starvation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048634 regulation of muscle organ development; GO:0048641 regulation of skeletal muscle tissue development; GO:0048742 regulation of skeletal muscle fiber development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051147 regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901861 regulation of muscle tissue development; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:2000026 regulation of multicellular organismal development; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00646; PF10442","PF00646 F-box domain; PF10442 FIST C domain",{"$nulls":6},"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-8951664 Neddylation;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8951664;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["Q8NFF5","FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1","FLAD1",0.801587715,0.070970112,"nochange",13985,15735.8,18272.7,13154.1,13565.6,11751.3,0.970456083,1.091948719,1.26799091,0.912797738,0.94135281,0.815453741,"cytoplasm","K00953","FLAD1; FAD synthetase [EC:2.7.7.2]","hsa00740 Riboflavin metabolism; hsa01240 Biosynthesis of cofactors; hsa01100 Metabolic pathways","GO:0006139 nucleobase-containing compound metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006747 FAD biosynthetic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006771 riboflavin metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009987 cellular process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042726 flavin-containing compound metabolic process; GO:0042727 flavin-containing compound biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046443 FAD metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0072387 flavin adenine dinucleotide metabolic process; GO:0072388 flavin adenine dinucleotide biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;","GO:0003824 catalytic activity; GO:0003919 FMN adenylyltransferase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0070566 adenylyltransferase activity;","PF00994","PF00994 Probable molybdopterin binding domain","EH","KOG2644","3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes","WP176 FOLATE METABOLISM;WP5037 RIBOFLAVIN AND COQ DISORDERS;WP15 SELENIUM MICRONUTRIENT NETWORK","http://www.wikipathways.org/instance/WP176_r120275;http://www.wikipathways.org/instance/WP5037_r120417;http://www.wikipathways.org/instance/WP15_r118387",null,"R-HSA-1430728 Metabolism;R-HSA-196843 Vitamin B2 (riboflavin) metabolism;R-HSA-196849 Metabolism of water-soluble vitamins and cofactors;R-HSA-196854 Metabolism of vitamins and cofactors","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-196843;https://reactome.org/PathwayBrowser/#/R-HSA-196849;https://reactome.org/PathwayBrowser/#/R-HSA-196854"]
["Q8NHM5","Lysine-specific demethylase 2B OS=Homo sapiens OX=9606 GN=KDM2B PE=1 SV=1","KDM2B",0.87613247,0.080571167,"nochange",12322.1,11489.9,10921.8,10884.9,9315.61,10230.9,1.134540961,1.057917254,1.005610202,1.002212684,0.857722395,0.941996504,"nucleus","K10276",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001558 regulation of cell growth; GO:0001654 eye development; GO:0001838 embryonic epithelial tube formation; GO:0001841 neural tube formation; GO:0001843 neural tube closure; GO:0002009 morphogenesis of an epithelium; GO:0002164 larval development; GO:0003002 regionalization; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006482 protein demethylation; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006513 protein monoubiquitination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007379 segment specification; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007525 somatic muscle development; GO:0007526 larval somatic muscle development; GO:0008152 metabolic process; GO:0008214 protein dealkylation; GO:0008285 negative regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0010390 histone monoubiquitination; GO:0010468 regulation of gene expression; GO:0010498 proteasomal protein catabolic process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0014020 primary neural tube formation; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0016567 protein ubiquitination; GO:0016570 histone modification; GO:0016574 histone ubiquitination; GO:0016577 histone demethylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0021532 neural tube patterning; GO:0021537 telencephalon development; GO:0021555 midbrain-hindbrain boundary morphogenesis; GO:0021591 ventricular system development; GO:0021592 fourth ventricle development; GO:0021670 lateral ventricle development; GO:0021678 third ventricle development; GO:0021903 rostrocaudal neural tube patterning; GO:0021915 neural tube development; GO:0021993 initiation of neural tube closure; GO:0022414 reproductive process; GO:0030163 protein catabolic process; GO:0030307 positive regulation of cell growth; GO:0030900 forebrain development; GO:0030901 midbrain development; GO:0030902 hindbrain development; GO:0030917 midbrain-hindbrain boundary development; GO:0031076 embryonic camera-type eye development; GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033522 histone H2A ubiquitination; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034720 histone H3-K4 demethylation; GO:0034721 histone H3-K4 demethylation"," trimethyl-H3-K4-specific; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035282 segmentation; GO:0035295 tube development; GO:0035518 histone H2A monoubiquitination; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0042127 regulation of cell population proliferation; GO:0042981 regulation of apoptotic process; GO:0043009 chordate embryonic development; GO:0043010 camera-type eye development; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048048 embryonic eye morphogenesis; GO:0048232 male gamete generation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048569 post-embryonic animal organ development; GO:0048592 eye morphogenesis; GO:0048593 camera-type eye morphogenesis; GO:0048596 embryonic camera-type eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0060562 epithelial tube morphogenesis; GO:0060606 tube closure; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070076 histone lysine demethylation; GO:0070544 histone H3-K36 demethylation; GO:0070647 protein modification by small protein conjugation or removal; GO:0070988 demethylation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072175 epithelial tube formation; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090596 sensory organ morphogenesis; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902459 positive regulation of stem cell population maintenance; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000036 regulation of stem cell population maintenance; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0019005 SCF ubiquitin ligase complex; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031519 PcG protein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0016491 oxidoreductase activity; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0032451 demethylase activity; GO:0032452 histone demethylase activity; GO:0032453 histone H3-methyl-lysine-4 demethylase activity; GO:0034647 histone H3-tri/di/monomethyl-lysine-4 demethylase activity; GO:0043565 sequence-specific DNA binding; GO:0051213 dioxygenase activity; GO:0051864 histone H3-methyl-lysine-36 demethylase activity; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF17811; PF02008; PF16866; PF00646","PF17811 Jumonji helical domain; PF02008 CXXC zinc finger domain; PF16866 PHD-finger; PF00646 F-box domain","R","KOG1947","Leucine rich repeat proteins"," some proteins contain F-box","WP4553 FBXL10 ENHANCEMENT OF MAPERK SIGNALING IN DIFFUSE LARGE BCELL LYMPHOMA","http://www.wikipathways.org/instance/WP4553_r103606","Transcription factor","R-HSA-3214842 HDMs demethylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214842;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["Q8TAE8","Growth arrest and DNA damage-inducible proteins-interacting protein 1 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1","GADD45GIP1",0.812881464,0.12112802,"nochange",9868.55,10261.2,10539.9,7405.37,10226.4,7299.02,1.064943011,1.107314978,1.13739028,0.799134323,1.103559612,0.787657796,"mitochondria",{"$nulls":3},"GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007049 cell cycle; GO:0007346 regulation of mitotic cell cycle; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045786 negative regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051707 response to other organism; GO:0051726 regulation of cell cycle; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060148 positive regulation of posttranscriptional gene silencing; GO:0060255 regulation of macromolecule metabolic process; GO:0060966 regulation of gene silencing by RNA; GO:0065007 biological regulation; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0070920 regulation of production of small RNA involved in gene silencing by RNA; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090065 regulation of production of siRNA involved in RNA interference; GO:0098586 cellular response to virus; GO:0140053 mitochondrial gene expression; GO:1900368 regulation of RNA interference; GO:1900370 positive regulation of RNA interference; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903705 positive regulation of production of siRNA involved in RNA interference;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen;",{"$nulls":3},"WV","KOG4848","Extracellular matrix-associated peroxidase",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q8TAG9","Exocyst complex component 6 OS=Homo sapiens OX=9606 GN=EXOC6 PE=1 SV=3","EXOC6",0.700724569,0.023761474,"nochange",23084.5,26660.8,21911.1,19592.9,15202.9,15415.6,1.136534835,1.312609237,1.078764038,0.964630526,0.74849468,0.758966684,"cytoplasm","nucleus","K19985",null,null,"GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001505 regulation of neurotransmitter levels; GO:0001667 ameboidal-type cell migration; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002262 myeloid cell homeostasis; GO:0002376 immune system process; GO:0002520 immune system development; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006836 neurotransmitter transport; GO:0006887 exocytosis; GO:0006903 vesicle targeting; GO:0006904 vesicle docking involved in exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007269 neurotransmitter secretion; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009453 energy taxis; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0016043 cellular component organization; GO:0016079 synaptic vesicle exocytosis; GO:0016080 synaptic vesicle targeting; GO:0016081 synaptic vesicle docking; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016477 cell migration; GO:0017156 calcium-ion regulated exocytosis; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022406 membrane docking; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0023052 signaling; GO:0023061 signal release; GO:0030030 cell projection organization; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030218 erythrocyte differentiation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0032456 endocytic recycling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032940 secretion by cell; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0034101 erythrocyte homeostasis; GO:0034613 cellular protein localization; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0042331 phototaxis; GO:0042592 homeostatic process; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048278 vesicle docking; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048534 hematopoietic or lymphoid organ development; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048872 homeostasis of number of cells; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0060429 epithelium development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090522 vesicle tethering involved in exocytosis; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0097485 neuron projection guidance; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099022 vesicle tethering; GO:0099504 synaptic vesicle cycle; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0099643 signal release from synapse; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:0140029 exocytic process; GO:0140056 organelle localization by membrane tethering; GO:1990778 protein localization to cell periphery;","GO:0000145 exocyst; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030424 axon; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0055037 recycling endosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0099023 vesicle tethering complex; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding;",null,null,"U","KOG2176","Exocyst complex"," subunit SEC15","WP4352 CILIARY LANDSCAPE;WP3670 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP3670_r117829",null,"R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-199991 Membrane Trafficking;R-HSA-264876 Insulin processing;R-HSA-2980736 Peptide hormone metabolism;R-HSA-392499 Metabolism of proteins;R-HSA-5617833 Cilium Assembly;R-HSA-5620916 VxPx cargo-targeting to cilium;R-HSA-5620920 Cargo trafficking to the periciliary membrane;R-HSA-5653656 Vesicle-mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-1445148;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-264876;https://reactome.org/PathwayBrowser/#/R-HSA-2980736;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620916;https://reactome.org/PathwayBrowser/#/R-HSA-5620920;https://reactome.org/PathwayBrowser/#/R-HSA-5653656"]
["Q8TBZ3","WD repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=WDR20 PE=1 SV=2","WDR20",1.095845409,0.371640393,"nochange",2249.12,1911.41,1887.96,2427.52,2277.79,1922.9,1.064529412,0.904688129,0.893589026,1.148967791,1.07809919,0.910126452,"cytoplasm","K24741",null,null,"GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016579 protein deubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045862 positive regulation of proteolysis; GO:0048518 positive regulation of biological process; GO:0048520 positive regulation of behavior; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090085 regulation of protein deubiquitination; GO:0090325 regulation of locomotion involved in locomotory behavior; GO:0090326 positive regulation of locomotion involved in locomotory behavior; GO:1901564 organonitrogen compound metabolic process; GO:1903003 positive regulation of protein deubiquitination; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903829 positive regulation of protein localization; GO:2000008 regulation of protein localization to cell surface; GO:2000010 positive regulation of protein localization to cell surface;",null,"GO:0005488 binding; GO:0005515 protein binding;",null,null,"R","KOG2394","WD40 protein DMR-N9",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689880;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta OS=Homo sapiens OX=9606 GN=PI4K2B PE=1 SV=1","PI4K2B",0.493759027,0.010422017,"nochange",4231.4,5603.22,4739.23,2436.38,2921.51,1838.08,1.166220024,1.544308589,1.306183515,0.67149292,0.805200043,0.50659491,"nucleus","K13711","PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007032 endosome organization; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016310 phosphorylation; GO:0019637 organophosphate metabolic process; GO:0030258 lipid modification; GO:0032252 secretory granule localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033333 fin development; GO:0033339 pectoral fin development; GO:0033363 secretory granule organization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046834 lipid phosphorylation; GO:0046854 phosphatidylinositol phosphate biosynthetic process; GO:0048736 appendage development; GO:0048856 anatomical structure development; GO:0051179 localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090407 organophosphate biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0018995 host cellular component; GO:0030425 dendrite; GO:0030427 site of polarized growth; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0033643 host cell part; GO:0033644 host cell membrane; GO:0035838 growing cell tip; GO:0036477 somatodendritic compartment; GO:0042734 presynaptic membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043657 host cell; GO:0044217 other organism part; GO:0044218 other organism cell membrane; GO:0044221 host cell synapse; GO:0044231 host cell presynaptic membrane; GO:0044297 cell body; GO:0045121 membrane raft; GO:0045202 synapse; GO:0051286 cell tip; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0098852 lytic vacuole membrane; GO:0098857 membrane microdomain; GO:0120025 plasma membrane bounded cell projection;","GO:0000166 nucleotide binding; GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0004430 1-phosphatidylinositol 4-kinase activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0035651 AP-3 adaptor complex binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0044877 protein-containing complex binding; GO:0046872 metal ion binding; GO:0052742 phosphatidylinositol kinase activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"T","KOG2381","Phosphatidylinositol 4-kinase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483248 Synthesis of PIPs at the ER membrane;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-1660514 Synthesis of PIPs at the Golgi membrane;R-HSA-1660516 Synthesis of PIPs at the early endosome membrane;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483248;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-1660514;https://reactome.org/PathwayBrowser/#/R-HSA-1660516;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["Q8TDQ7","Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1","GNPDA2",1.420246063,0.000705211,"up",15021.8,14191.3,13743.4,19464,20212.1,21332.7,0.866931563,0.819002109,0.7931531,1.12329787,1.16647189,1.231143468,"cytoplasm","K02564","nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6]","hsa00520 Amino sugar and nucleotide sugar metabolism; hsa01100 Metabolic pathways","GO:0006040 amino sugar metabolic process; GO:0006041 glucosamine metabolic process; GO:0006043 glucosamine catabolic process; GO:0006044 N-acetylglucosamine metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009987 cellular process; GO:0044237 cellular metabolic process; GO:0046348 amino sugar catabolic process; GO:0071704 organic substance metabolic process; GO:1901071 glucosamine-containing compound metabolic process; GO:1901072 glucosamine-containing compound catabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004342 glucosamine-6-phosphate deaminase activity; GO:0016787 hydrolase activity; GO:0016853 isomerase activity; GO:0016860 intramolecular oxidoreductase activity; GO:0016861 intramolecular oxidoreductase activity"," interconverting aldoses and ketoses; GO:0019239 deaminase activity;","PF01182","PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase","G","KOG3148","Glucosamine-6-phosphate isomerase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-70171 Glycolysis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70171;https://reactome.org/PathwayBrowser/#/R-HSA-70326;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["Q8TEM1","Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3","NUP210",0.850815563,0.004515479,"down",40819.2,42515.8,41590.9,36300.1,36347.4,33641.4,1.059253992,1.103280586,1.079279527,0.941983818,0.943211248,0.872990829,"plasma membrane","K14314","NUP210; nuclear pore complex protein Nup210","hsa03013 Nucleocytoplasmic transport; hsa05014 Amyotrophic lateral sclerosis","GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0010467 gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016032 viral process; GO:0031503 protein-containing complex localization; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0017056 structural constituent of nuclear pore; GO:0046983 protein dimerization activity;","PF02368","PF02368 Bacterial Ig-like domain (group 2)","YU","KOG1833","Nuclear pore complex"," gp210 component",{"$nulls":3},"R-HSA-1169408 ISG15 antiviral mechanism;R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1430728 Metabolism;R-HSA-159227 Transport of the SLBP independent Mature mRNA;R-HSA-159230 Transport of the SLBP Dependant Mature mRNA;R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript;R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts;R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-162587 HIV Life Cycle;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-165054 Rev-mediated nuclear export of HIV RNA;R-HSA-168255 Influenza Infection;R-HSA-168256 Immune System;R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus;R-HSA-168276 NS1 Mediated Effects on Host Pathways;R-HSA-168325 Viral Messenger RNA Synthesis;R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery;R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein;R-HSA-176033 Interactions of Vpr with host cellular proteins;R-HSA-177243 Interactions of Rev with host cellular proteins;R-HSA-180746 Nuclear import of Rev protein;R-HSA-180910 Vpr-mediated nuclear import of PICs;R-HSA-191859 snRNP Assembly;R-HSA-194441 Metabolism of non-coding RNA;R-HSA-211000 Gene Silencing by RNA;R-HSA-2262752 Cellular responses to stress;R-HSA-2980766 Nuclear Envelope Breakdown;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-3232142 SUMOylation of ubiquitinylation proteins;R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly;R-HSA-3371453 Regulation of HSF1-mediated heat shock response;R-HSA-3371556 Cellular response to heat stress;R-HSA-392499 Metabolism of proteins;R-HSA-4085377 SUMOylation of SUMOylation proteins;R-HSA-4551638 SUMOylation of chromatin organization proteins;R-HSA-4570464 SUMOylation of RNA binding proteins;R-HSA-4615885 SUMOylation of DNA replication proteins;R-HSA-5578749 Transcriptional regulation by small RNAs;R-HSA-5619102 SLC transporter disorders;R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC);R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5663205 Infectious disease;R-HSA-597592 Post-translational protein modification;R-HSA-6784531 tRNA processing in the nucleus;R-HSA-68875 Mitotic Prophase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-70171 Glycolysis;R-HSA-70326 Glucose metabolism;R-HSA-71387 Metabolism of carbohydrates;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-72306 tRNA processing;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-913531 Interferon Signaling;R-HSA-9609646 HCMV Infection;R-HSA-9609690 HCMV Early Events;R-HSA-9610379 HCMV Late Events;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses;R-HSA-9705683 SARS-CoV-2-host interactions"]
["Q8TER5","Rho guanine nucleotide exchange factor 40 OS=Homo sapiens OX=9606 GN=ARHGEF40 PE=1 SV=3","ARHGEF40",0.671038236,0.43644842,"nochange",2362.04,2291.55,2135.62,"NA",2077.59,959.623,1.201881906,1.166014327,1.086672129,"NA",1.057144599,0.48828704,"nucleus","K24316",{"$nulls":5},"PF00621","PF00621 RhoGEF domain","T","KOG0689","Guanine nucleotide exchange factor for Rho and Rac GTPases",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-193648 NRAGE signals death through JNK;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-194315 Signaling by Rho GTPases;R-HSA-204998 Cell death signalling via NRAGE"," NRIF and NADE;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-416482 G alpha (12/13) signalling events;R-HSA-73887 Death Receptor Signalling;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013106 RHOC GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-193648;https://reactome.org/PathwayBrowser/#/R-HSA-193704;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-204998;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-416482;https://reactome.org/PathwayBrowser/#/R-HSA-73887;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013106;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q8WTT2","Nucleolar complex protein 3 homolog OS=Homo sapiens OX=9606 GN=NOC3L PE=1 SV=1","NOC3L",0.661813116,0.000457281,"down",32015.2,30396,34068,21332,22030.3,20488.9,1.198095932,1.13750106,1.274917296,0.798301507,0.824433794,0.76675041,"nucleus","K14834",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007275 multicellular organism development; GO:0007517 muscle organ development; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019216 regulation of lipid metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0045444 fat cell differentiation; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0140110 transcription regulator activity;",null,null,"JU","KOG2153","Protein involved in the nuclear export of pre-ribosomes"]
["Q8WUI4","Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2","HDAC7",0.842537626,0.001738981,"down",9916.04,9943.52,9690.42,7982.33,8600.83,8313.81,1.092737793,1.095766062,1.067874693,0.879644865,0.947802953,0.916173633,"nucleus","K11408","HDAC7; histone deacetylase 7 [EC:3.5.1.98]","hsa04613 Neutrophil extracellular trap formation; hsa05203 Viral carcinogenesis; hsa05034 Alcoholism","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001568 blood vessel development; GO:0001570 vasculogenesis; GO:0001775 cell activation; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001944 vasculature development; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0003008 system process; GO:0003012 muscle system process; GO:0003299 muscle hypertrophy in response to stress; GO:0003300 cardiac muscle hypertrophy; GO:0006109 regulation of carbohydrate metabolic process; GO:0006110 regulation of glycolytic process; GO:0006140 regulation of nucleotide metabolic process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006476 protein deacetylation; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006996 organelle organization; GO:0007043 cell-cell junction assembly; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007507 heart development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007613 memory; GO:0007616 long-term memory; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008284 positive regulation of cell population proliferation; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009612 response to mechanical stimulus; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010596 negative regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010633 negative regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010677 negative regulation of cellular carbohydrate metabolic process; GO:0010830 regulation of myotube differentiation; GO:0010832 negative regulation of myotube differentiation; GO:0010941 regulation of cell death; GO:0012501 programmed cell death; GO:0014854 response to inactivity; GO:0014870 response to muscle inactivity; GO:0014874 response to stimulus involved in regulation of muscle adaptation; GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation; GO:0014887 cardiac muscle adaptation; GO:0014888 striated muscle adaptation; GO:0014894 response to denervation involved in regulation of muscle adaptation; GO:0014896 muscle hypertrophy; GO:0014897 striated muscle hypertrophy; GO:0014898 cardiac muscle hypertrophy in response to stress; GO:0016043 cellular component organization; GO:0016202 regulation of striated muscle tissue development; GO:0016525 negative regulation of angiogenesis; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0016575 histone deacetylation; GO:0016925 protein sumoylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030183 B cell differentiation; GO:0030278 regulation of ossification; GO:0030279 negative regulation of ossification; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030808 regulation of nucleotide biosynthetic process; GO:0030809 negative regulation of nucleotide biosynthetic process; GO:0030811 regulation of nucleotide catabolic process; GO:0030812 negative regulation of nucleotide catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032663 regulation of interleukin-2 production; GO:0032703 negative regulation of interleukin-2 production; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032879 regulation of localization; GO:0033233 regulation of protein sumoylation; GO:0033235 positive regulation of protein sumoylation; GO:0033554 cellular response to stress; GO:0034097 response to cytokine; GO:0034329 cell junction assembly; GO:0034330 cell junction organization; GO:0034983 peptidyl-lysine deacetylation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035601 protein deacylation; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0040029 regulation of gene expression"," epigenetic; GO:0042113 B cell activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042594 response to starvation; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043434 response to peptide hormone; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043470 regulation of carbohydrate catabolic process; GO:0043500 muscle adaptation; GO:0043502 regulation of muscle adaptation; GO:0043535 regulation of blood vessel endothelial cell migration; GO:0043536 positive regulation of blood vessel endothelial cell migration; GO:0043537 negative regulation of blood vessel endothelial cell migration; GO:0043543 protein acylation; GO:0044057 regulation of system process; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045216 cell-cell junction organization; GO:0045321 leukocyte activation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045667 regulation of osteoblast differentiation; GO:0045668 negative regulation of osteoblast differentiation; GO:0045765 regulation of angiogenesis; GO:0045766 positive regulation of angiogenesis; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045820 negative regulation of glycolytic process; GO:0045843 negative regulation of striated muscle tissue development; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045912 negative regulation of carbohydrate metabolic process; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0045980 negative regulation of nucleotide metabolic process; GO:0046626 regulation of insulin receptor signaling pathway; GO:0046627 negative regulation of insulin receptor signaling pathway; GO:0046649 lymphocyte activation; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048634 regulation of muscle organ development; GO:0048635 negative regulation of muscle organ development; GO:0048641 regulation of skeletal muscle tissue development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048742 regulation of skeletal muscle fiber development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051147 regulation of muscle cell differentiation; GO:0051148 negative regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051154 negative regulation of striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051276 chromosome organization; GO:0051402 neuron apoptotic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0062012 regulation of small molecule metabolic process; GO:0062014 negative regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070555 response to interleukin-1; GO:0070647 protein modification by small protein conjugation or removal; GO:0070887 cellular response to chemical stimulus; GO:0070932 histone H3 deacetylation; GO:0070933 histone H4 deacetylation; GO:0070997 neuron death; GO:0071214 cellular response to abiotic stimulus; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071496 cellular response to external stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090049 regulation of cell migration involved in sprouting angiogenesis; GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis; GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis; GO:0090257 regulation of muscle system process; GO:0098732 macromolecule deacylation; GO:0104004 cellular response to environmental stimulus; GO:1900076 regulation of cellular response to insulin stimulus; GO:1900077 negative regulation of cellular response to insulin stimulus; GO:1900371 regulation of purine nucleotide biosynthetic process; GO:1900372 negative regulation of purine nucleotide biosynthetic process; GO:1900542 regulation of purine nucleotide metabolic process; GO:1900543 negative regulation of purine nucleotide metabolic process; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901223 negative regulation of NIK/NF-kappaB signaling; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901564 organonitrogen compound metabolic process; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901861 regulation of muscle tissue development; GO:1901862 negative regulation of muscle tissue development; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903578 regulation of ATP metabolic process; GO:1903579 negative regulation of ATP metabolic process; GO:1903670 regulation of sprouting angiogenesis; GO:1903671 negative regulation of sprouting angiogenesis; GO:1903672 positive regulation of sprouting angiogenesis; GO:1904018 positive regulation of vasculature development; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2001141 regulation of RNA biosynthetic process; GO:2001169 regulation of ATP biosynthetic process; GO:2001170 negative regulation of ATP biosynthetic process;","GO:0000118 histone deacetylase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0017053 transcription repressor complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0003824 catalytic activity; GO:0004407 histone deacetylase activity; GO:0005080 protein kinase C binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016811 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in linear amides; GO:0019213 deacetylase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019789 SUMO transferase activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030955 potassium ion binding; GO:0031420 alkali metal ion binding; GO:0033558 protein deacetylase activity; GO:0042802 identical protein binding; GO:0042826 histone deacetylase binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0071889 14-3-3 protein binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00850","PF00850 Histone deacetylase domain","B","KOG1343","Histone deacetylase complex"," catalytic component HDA1","WP2795 CARDIAC HYPERTROPHIC RESPONSE;WP3996 ETHANOL EFFECTS ON HISTONE MODIFICATIONS;WP4659 GASTRIN SIGNALING PATHWAY;WP3414 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV1 LTR;WP1544 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY;WP2064 NEURAL CREST DIFFERENTIATION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2795_r117670;http://www.wikipathways.org/instance/WP3996_r107156;http://www.wikipathways.org/instance/WP4659_r116555;http://www.wikipathways.org/instance/WP3414_r106735;http://www.wikipathways.org/instance/WP1544_r108800;http://www.wikipathways.org/instance/WP2064_r117162;http://www.wikipathways.org/instance/WP3888_r116782","Transcription factor","R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-1980143 Signaling by NOTCH1;R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription;R-HSA-212436 Generic Transcription Pathway;R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer;R-HSA-2644603 Signaling by NOTCH1 in Cancer;R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants;R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer;R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants;R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-350054 Notch-HLH transcription pathway;R-HSA-392499 Metabolism of proteins;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-597592 Post-translational protein modification;R-HSA-6807070 PTEN Regulation;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8943724 Regulation of PTEN gene transcription;R-HSA-9006925 Intracellular signaling by second messengers","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-157118;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-1980143;https://reactome.org/PathwayBrowser/#/R-HSA-2122947;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2644602;https://reactome.org/PathwayBrowser/#/R-HSA-2644603;https://reactome.org/PathwayBrowser/#/R-HSA-2644606;https://reactome.org/PathwayBrowser/#/R-HSA-2894858;https://reactome.org/PathwayBrowser/#/R-HSA-2894862;https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108214;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-350054;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8943724;https://reactome.org/PathwayBrowser/#/R-HSA-9006925"]
["Q8WVC0","RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1","LEO1",0.83294135,0.030107908,"nochange",20454.4,22114.9,19763.3,18588.5,15927.6,17403.3,1.074172881,1.161374856,1.037879424,0.976184224,0.836445751,0.913942863,"nucleus","K15177",null,null,"GO:0001501 skeletal system development; GO:0001704 formation of primary germ layer; GO:0001706 endoderm formation; GO:0001711 endodermal cell fate commitment; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006351 transcription"," DNA-templated; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006378 mRNA polyadenylation; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006513 protein monoubiquitination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007492 endoderm development; GO:0007507 heart development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010390 histone monoubiquitination; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0014031 mesenchymal cell development; GO:0014032 neural crest cell development; GO:0014033 neural crest cell differentiation; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016567 protein ubiquitination; GO:0016570 histone modification; GO:0016574 histone ubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019827 stem cell population maintenance; GO:0021510 spinal cord development; GO:0021515 cell differentiation in spinal cord; GO:0021529 spinal cord oligodendrocyte cell differentiation; GO:0021782 glial cell development; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0030318 melanocyte differentiation; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031440 regulation of mRNA 3'-end processing; GO:0031442 positive regulation of mRNA 3'-end processing; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032784 regulation of DNA-templated transcription"," elongation; GO:0032786 positive regulation of DNA-templated transcription"," elongation; GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter; GO:0033523 histone H2B ubiquitination; GO:0034243 regulation of transcription elongation from RNA polymerase II promoter; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035987 endodermal cell differentiation; GO:0036211 protein modification process; GO:0042063 gliogenesis; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043473 pigmentation; GO:0043631 RNA polyadenylation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045638 negative regulation of myeloid cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048066 developmental pigmentation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048701 embryonic cranial skeleton morphogenesis; GO:0048704 embryonic skeletal system morphogenesis; GO:0048705 skeletal system morphogenesis; GO:0048706 embryonic skeletal system development; GO:0048709 oligodendrocyte differentiation; GO:0048731 system development; GO:0048762 mesenchymal cell differentiation; GO:0048856 anatomical structure development; GO:0048863 stem cell differentiation; GO:0048864 stem cell development; GO:0048869 cellular developmental process; GO:0050684 regulation of mRNA processing; GO:0050685 positive regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050931 pigment cell differentiation; GO:0050936 xanthophore differentiation; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060485 mesenchyme development; GO:0060795 cell fate commitment involved in formation of primary germ layer; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903313 positive regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:1904837 beta-catenin-TCF complex assembly; GO:1904888 cranial skeletal system development; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0008023 transcription elongation factor complex; GO:0015630 microtubule cytoskeleton; GO:0016591 RNA polymerase II"," holoenzyme; GO:0016593 Cdc73/Paf1 complex; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000993 RNA polymerase II complex binding; GO:0001098 basal transcription machinery binding; GO:0001099 basal RNA polymerase II transcription machinery binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0043175 RNA polymerase core enzyme binding; GO:0044877 protein-containing complex binding; GO:0045309 protein phosphorylated amino acid binding; GO:0050815 phosphoserine residue binding; GO:0051219 phosphoprotein binding; GO:0070063 RNA polymerase binding; GO:0099122 RNA polymerase II C-terminal domain binding; GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding;",null,null,"S","KOG2428","Uncharacterized conserved protein","WP2853 ENDODERM DIFFERENTIATION","http://www.wikipathways.org/instance/WP2853_r116557","Transcription factor","R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-162582 Signal Transduction;R-HSA-195721 Signaling by WNT;R-HSA-201681 TCF dependent signaling in response to WNT;R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins","https://reactome.org/PathwayBrowser/#/R-HSA-112382;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-195721;https://reactome.org/PathwayBrowser/#/R-HSA-201681;https://reactome.org/PathwayBrowser/#/R-HSA-201722;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-674695;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75955;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654"]
["Q8WWI1","LIM domain only protein 7 OS=Homo sapiens OX=9606 GN=LMO7 PE=1 SV=3","LMO7",0.73427038,0.047391025,"nochange",1634.95,1620.56,2028.47,1272.53,1485.86,1121.48,1.07047802,1.061056215,1.328133918,0.833184742,0.972861843,0.734285262,"nucleus","K06084","LMO7; F-box protein 20","hsa04520 Adherens junction","GO:0000209 protein polyubiquitination; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016567 protein ubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032446 protein modification by small protein conjugation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016324 apical plasma membrane; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0031430 M band; GO:0031672 A band; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0045177 apical part of cell; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003700 DNA-binding transcription factor activity; GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019904 protein domain specific binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity;","PF00307; PF00595; PF00412","PF00307 Calponin homology (CH) domain; PF00595 PDZ domain; PF00412 LIM domain","TZR","KOG1704","FOG: LIM domain",{"$nulls":3},"R-HSA-1280218 Adaptive Immune System;R-HSA-1643685 Disease;R-HSA-168256 Immune System;R-HSA-392499 Metabolism of proteins;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-597592 Post-translational protein modification;R-HSA-8951664 Neddylation;R-HSA-9700206 Signaling by ALK in cancer;R-HSA-9725370 Signaling by ALK fusions and activated point mutants;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8951664;https://reactome.org/PathwayBrowser/#/R-HSA-9700206;https://reactome.org/PathwayBrowser/#/R-HSA-9725370;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["Q8WWV3","Reticulon-4-interacting protein 1"," mitochondrial OS=Homo sapiens OX=9606 GN=RTN4IP1 PE=1 SV=2","RTN4IP1",0.846427858,0.085837397,"nochange",5595.91,4403.83,4864.87,4055.01,4255.7,4271.11,1.223308824,0.962710997,1.063497876,0.886456271,0.930328644,0.933697388,"mitochondria","K23164",null,null,"GO:0000003 reproduction; GO:0000302 response to reactive oxygen species; GO:0000303 response to superoxide; GO:0000305 response to oxygen radical; GO:0001654 eye development; GO:0001754 eye photoreceptor cell differentiation; GO:0002376 immune system process; GO:0003407 neural retina development; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006979 response to oxidative stress; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0010035 response to inorganic substance; GO:0010842 retina layer formation; GO:0010975 regulation of neuron projection development; GO:0016319 mushroom body development; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031344 regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0040008 regulation of growth; GO:0040009 regulation of growth rate; GO:0040010 positive regulation of growth rate; GO:0040014 regulation of multicellular organism growth; GO:0042221 response to chemical; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0042742 defense response to bacterium; GO:0043010 camera-type eye development; GO:0043207 response to external biotic stimulus; GO:0045087 innate immune response; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045927 positive regulation of growth; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048592 eye morphogenesis; GO:0048593 camera-type eye morphogenesis; GO:0048638 regulation of developmental growth; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050829 defense response to Gram-negative bacterium; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051707 response to other organism; GO:0051960 regulation of nervous system development; GO:0060041 retina development in camera-type eye; GO:0060042 retina morphogenesis in camera-type eye; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0090596 sensory organ morphogenesis; GO:0098542 defense response to other organism; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901700 response to oxygen-containing compound; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0016020 membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle;",null,"PF08240; PF13602","PF08240 Alcohol dehydrogenase GroES-like domain; PF13602 Zinc-binding dehydrogenase","CR","KOG1198","Zinc-binding oxidoreductase"]
["Q8WYA6","Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1","CTNNBL1",1.313922817,0.000161439,"up",68244.6,64065.1,65967.7,87478.5,87550.4,85492.3,0.892477876,0.837819906,0.862701412,1.144011773,1.144952055,1.118036977,"cytoplasm","nucleus","K12864","CTNNBL1; beta-catenin-like protein 1","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0002200 somatic diversification of immune receptors; GO:0002376 immune system process; GO:0002377 immunoglobulin production; GO:0002440 production of molecular mediator of immune response; GO:0002520 immune system development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016445 somatic diversification of immunoglobulins; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0000974 Prp19 complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding;","PF08216","PF08216 Catenin-beta-like"," Arm-motif containing nuclear","S","KOG2734","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q8WZA1","Protein O-linked-mannose beta-1","2-N-acetylglucosaminyltransferase 1 OS=Homo sapiens OX=9606 GN=POMGNT1 PE=1 SV=2","POMGNT1",1.167870802,0.227397187,"nochange",4623.12,3366.81,4215.23,5190.91,4849.19,4213.95,1.048357831,0.763471774,0.955863006,1.177112242,1.0996224,0.955572748,"plasma membrane","K09666","POMGNT1; beta-1","2-N-acetylglucosaminyltransferase [EC:2.4.1.-]","hsa00515 Mannose type O-glycan biosynthesis; hsa01100 Metabolic pathways","GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009987 cellular process; GO:0016266 O-glycan processing; GO:0019538 protein metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030173 integral component of Golgi membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031228 intrinsic component of Golgi membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0008194 UDP-glycosyltransferase activity; GO:0008375 acetylglucosaminyltransferase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0030145 manganese ion binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0047223 beta-1","3-galactosyl-O-glycosyl-glycoprotein beta-1","3-N-acetylglucosaminyltransferase activity; GO:0140096 catalytic activity"," acting on a protein; GO:0140103 catalytic activity"," acting on a glycoprotein;","PF15711","PF15711 Interleukin-like EMT inducer",{"$nulls":3},"WP4803 CILIOPATHIES","http://www.wikipathways.org/instance/WP4803_r110008",null,"R-HSA-1643685 Disease;R-HSA-3781865 Diseases of glycosylation;R-HSA-3906995 Diseases associated with O-glycosylation of proteins;R-HSA-392499 Metabolism of proteins;R-HSA-5083628 Defective POMGNT1 causes MDDGA3"," MDDGB3 and MDDGC3;R-HSA-5173105 O-linked glycosylation;R-HSA-5668914 Diseases of metabolism;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-3781865;https://reactome.org/PathwayBrowser/#/R-HSA-3906995;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5083628;https://reactome.org/PathwayBrowser/#/R-HSA-5173105;https://reactome.org/PathwayBrowser/#/R-HSA-5668914;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q92541","RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4","RTF1",0.895571156,0.003358594,"down",38252.5,36787.2,38687.5,34168.8,33357.4,34324.6,1.064649454,1.023866999,1.076756441,0.950991289,0.928408279,0.955327538,"extracellular","K15178",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001701 in utero embryonic development; GO:0001704 formation of primary germ layer; GO:0001706 endoderm formation; GO:0001711 endodermal cell fate commitment; GO:0001824 blastocyst development; GO:0001832 blastocyst growth; GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006351 transcription"," DNA-templated; GO:0006354 DNA-templated transcription"," elongation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006368 transcription elongation from RNA polymerase II promoter; GO:0006464 cellular protein modification process; GO:0006479 protein methylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007492 endoderm development; GO:0008152 metabolic process; GO:0008213 protein alkylation; GO:0008593 regulation of Notch signaling pathway; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016567 protein ubiquitination; GO:0016570 histone modification; GO:0016571 histone methylation; GO:0018022 peptidyl-lysine methylation; GO:0018023 peptidyl-lysine trimethylation; GO:0018130 heterocycle biosynthetic process; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019827 stem cell population maintenance; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031060 regulation of histone methylation; GO:0031062 positive regulation of histone methylation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032784 regulation of DNA-templated transcription"," elongation; GO:0032786 positive regulation of DNA-templated transcription"," elongation; GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034243 regulation of transcription elongation from RNA polymerase II promoter; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034968 histone lysine methylation; GO:0035987 endodermal cell differentiation; GO:0036211 protein modification process; GO:0040007 growth; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045165 cell fate commitment; GO:0045747 positive regulation of Notch signaling pathway; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048589 developmental growth; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051568 histone H3-K4 methylation; GO:0051569 regulation of histone H3-K4 methylation; GO:0051571 positive regulation of histone H3-K4 methylation; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060795 cell fate commitment involved in formation of primary germ layer; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080182 histone H3-K4 trimethylation; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905269 positive regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000428 DNA-directed RNA polymerase complex; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0008023 transcription elongation factor complex; GO:0016591 RNA polymerase II"," holoenzyme; GO:0016593 Cdc73/Paf1 complex; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0000993 RNA polymerase II complex binding; GO:0001098 basal transcription machinery binding; GO:0001099 basal RNA polymerase II transcription machinery binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003697 single-stranded DNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008276 protein methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016278 lysine N-methyltransferase activity; GO:0016279 protein-lysine N-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0018024 histone-lysine N-methyltransferase activity; GO:0019899 enzyme binding; GO:0042054 histone methyltransferase activity; GO:0042800 histone methyltransferase activity (H3-K4 specific); GO:0043175 RNA polymerase core enzyme binding; GO:0044877 protein-containing complex binding; GO:0045309 protein phosphorylated amino acid binding; GO:0050815 phosphoserine residue binding; GO:0051219 phosphoprotein binding; GO:0070063 RNA polymerase binding; GO:0097159 organic cyclic compound binding; GO:0099122 RNA polymerase II C-terminal domain binding; GO:0140096 catalytic activity"," acting on a protein; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding;","PF03126","PF03126 Plus-3 domain","K","KOG2402","Paf1/RNA polymerase II complex"," RTF1 component (involved in regulation of TATA box-binding protein)","WP2853 ENDODERM DIFFERENTIATION","http://www.wikipathways.org/instance/WP2853_r116557",null,"R-HSA-112382 Formation of RNA Pol II elongation complex ;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification;R-HSA-674695 RNA Polymerase II Pre-transcription Events;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-75955 RNA Polymerase II Transcription Elongation;R-HSA-8852135 Protein ubiquitination;R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins","https://reactome.org/PathwayBrowser/#/R-HSA-112382;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-674695;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-75955;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866654"]
["Q92556","Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2","ELMO1",1.075610793,0.00219059,"nochange",34910.6,34894.9,35307.8,37818.3,38240,37002.7,0.960074583,0.959642818,0.970997959,1.040039088,1.051636238,1.017609315,"cytoplasm","K12366","ELMO1; engulfment and cell motility protein 1","hsa05100 Bacterial invasion of epithelial cells; hsa04062 Chemokine signaling pathway; hsa05132 Salmonella infection; hsa05135 Yersinia infection; hsa05131 Shigellosis","GO:0000003 reproduction; GO:0000132 establishment of mitotic spindle orientation; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000768 syncytium formation by plasma membrane fusion; GO:0001667 ameboidal-type cell migration; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002431 Fc receptor mediated stimulatory signaling pathway; GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002757 immune response-activating signal transduction; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0006911 phagocytosis"," engulfment; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006949 syncytium formation; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007517 muscle organ development; GO:0007520 myoblast fusion; GO:0007548 sex differentiation; GO:0008219 cell death; GO:0008406 gonad development; GO:0009653 anatomical structure morphogenesis; GO:0009798 axis specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010324 membrane invagination; GO:0010631 epithelial cell migration; GO:0012501 programmed cell death; GO:0014902 myotube differentiation; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016203 muscle attachment; GO:0016477 cell migration; GO:0016601 Rac protein signal transduction; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030010 establishment of cell polarity; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031532 actin cytoskeleton reorganization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0035262 gonad morphogenesis; GO:0035556 intracellular signal transduction; GO:0038093 Fc receptor signaling pathway; GO:0038094 Fc-gamma receptor signaling pathway; GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis; GO:0040001 establishment of mitotic spindle localization; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042692 muscle cell differentiation; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043277 apoptotic cell clearance; GO:0043547 positive regulation of GTPase activity; GO:0043652 engulfment of apoptotic cell; GO:0044093 positive regulation of molecular function; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0045137 development of primary sexual characteristics; GO:0045807 positive regulation of endocytosis; GO:0048010 vascular endothelial growth factor receptor signaling pathway; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050690 regulation of defense response to virus by virus; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051293 establishment of spindle localization; GO:0051294 establishment of spindle orientation; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060097 cytoskeletal rearrangement involved in phagocytosis"," engulfment; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060100 positive regulation of phagocytosis"," engulfment; GO:0060429 epithelium development; GO:0060538 skeletal muscle organ development; GO:0060627 regulation of vesicle-mediated transport; GO:0060972 left/right pattern formation; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070986 left/right axis specification; GO:0071840 cellular component organization or biogenesis; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090630 activation of GTPase activity; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:0099024 plasma membrane invagination; GO:1901074 regulation of engulfment of apoptotic cell; GO:1901076 positive regulation of engulfment of apoptotic cell; GO:1902742 apoptotic process involved in development; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process; GO:1903354 regulation of distal tip cell migration; GO:1903356 positive regulation of distal tip cell migration; GO:1905153 regulation of membrane invagination; GO:1905155 positive regulation of membrane invagination; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000425 regulation of apoptotic cell clearance; GO:2000427 positive regulation of apoptotic cell clearance;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0032045 guanyl-nucleotide exchange factor complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery;","GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008289 lipid binding; GO:0017124 SH3 domain binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031267 small GTPase binding; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0044877 protein-containing complex binding; GO:0051020 GTPase binding; GO:0070064 proline-rich region binding; GO:0070273 phosphatidylinositol-4-phosphate binding; GO:0080025 phosphatidylinositol-3","5-bisphosphate binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF16457","PF16457 Pleckstrin homology domain","T","KOG2999","Regulator of Rac1"," required for phagocytosis and cell migration","WP3929 CHEMOKINE SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3929_r119247",null,"R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1643685 Disease;R-HSA-164944 Nef and signal transduction;R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194138 Signaling by VEGF;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-5663205 Infectious disease;R-HSA-8848021 Signaling by PTK6;R-HSA-8849471 PTK6 Regulates RHO GTPases"," RAS GTPase and MAP kinases;R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-162909;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-164944;https://reactome.org/PathwayBrowser/#/R-HSA-164952;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-4420097;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-8848021;https://reactome.org/PathwayBrowser/#/R-HSA-8849471;https://reactome.org/PathwayBrowser/#/R-HSA-9006927;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422"]
["Q92620","Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2","DHX38",1.207610276,0.001173485,"up",17972.1,18771.8,18150.3,21596.5,21773.1,22921.2,0.889818047,0.929412056,0.898640921,1.069265998,1.078009655,1.134853323,"nucleus","K12815","DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 [EC:3.6.4.13]","hsa03040 Spliceosome","GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007275 multicellular organism development; GO:0007530 sex determination; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018992 germ-line sex determination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022414 reproductive process; GO:0031123 RNA 3'-end processing; GO:0031124 mRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0040021 hermaphrodite germ-line sex determination; GO:0040022 feminization of hermaphroditic germ-line; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048856 anatomical structure development; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903311 regulation of mRNA metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003724 RNA helicase activity; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008186 ATP-dependent activity"," acting on RNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;","PF00270; PF00271; PF04408; PF07717","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain; PF04408 Helicase associated domain (HA2); PF07717 Oligonucleotide/oligosaccharide-binding (OB)-fold","A","KOG0924","mRNA splicing factor ATP-dependent RNA helicase","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72187 mRNA 3'-end processing;R-HSA-72202 Transport of Mature Transcript to Cytoplasm;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-73856 RNA Polymerase II Transcription Termination;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-159236;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72187;https://reactome.org/PathwayBrowser/#/R-HSA-72202;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-73856;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q92766","Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3","RREB1",1.165016181,0.092634296,"nochange",12837.2,14582.7,13709.4,15658.5,17721.3,14536.5,0.86498603,0.982599926,0.923755918,1.055088629,1.194082582,0.979486915,"nucleus","K20210",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000578 embryonic axis specification; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001709 cell fate determination; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001745 compound eye morphogenesis; GO:0001894 tissue homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0003002 regionalization; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0007154 cell communication; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007275 multicellular organism development; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007354 zygotic determination of anterior/posterior axis"," embryo; GO:0007362 terminal region determination; GO:0007389 pattern specification process; GO:0007390 germ-band shortening; GO:0007391 dorsal closure; GO:0007392 initiation of dorsal closure; GO:0007393 dorsal closure"," leading edge cell fate determination; GO:0007398 ectoderm development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007423 sensory organ development; GO:0007424 open tracheal system development; GO:0007444 imaginal disc development; GO:0007447 imaginal disc pattern formation; GO:0007450 dorsal/ventral pattern formation"," imaginal disc; GO:0008152 metabolic process; GO:0008258 head involution; GO:0008284 positive regulation of cell population proliferation; GO:0008293 torso signaling pathway; GO:0008594 photoreceptor cell morphogenesis; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010669 epithelial structure maintenance; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016318 ommatidial rotation; GO:0016331 morphogenesis of embryonic epithelium; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022008 neurogenesis; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030182 neuron differentiation; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030855 epithelial cell differentiation; GO:0030856 regulation of epithelial cell differentiation; GO:0030858 positive regulation of epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033599 regulation of mammary gland epithelial cell proliferation; GO:0033601 positive regulation of mammary gland epithelial cell proliferation; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035026 leading edge cell differentiation; GO:0035027 leading edge cell fate commitment; GO:0035028 leading edge cell fate determination; GO:0035029 dorsal closure"," leading edge cell fate commitment; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035160 maintenance of epithelial integrity"," open tracheal system; GO:0035220 wing disc development; GO:0035222 wing disc pattern formation; GO:0035282 segmentation; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042067 establishment of ommatidial planar polarity; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0042461 photoreceptor cell development; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045165 cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045785 positive regulation of cell adhesion; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT; GO:0046483 heterocycle metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0046663 dorsal closure"," leading edge cell differentiation; GO:0046665 amnioserosa maintenance; GO:0048190 wing disc dorsal/ventral pattern formation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0050678 regulation of epithelial cell proliferation; GO:0050679 positive regulation of epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051716 cellular response to stimulus; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060541 respiratory system development; GO:0061041 regulation of wound healing; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072148 epithelial cell fate commitment; GO:0072499 photoreceptor cell axon guidance; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090303 positive regulation of wound healing; GO:0090304 nucleic acid metabolic process; GO:0090596 sensory organ morphogenesis; GO:0097485 neuron projection guidance; GO:0097659 nucleic acid-templated transcription; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1900024 regulation of substrate adhesion-dependent cell spreading; GO:1900026 positive regulation of substrate adhesion-dependent cell spreading; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902743 regulation of lamellipodium organization; GO:1902745 positive regulation of lamellipodium organization; GO:1903034 regulation of response to wounding; GO:1903036 positive regulation of response to wounding; GO:1903076 regulation of protein localization to plasma membrane; GO:1903077 negative regulation of protein localization to plasma membrane; GO:1903385 regulation of homophilic cell adhesion; GO:1903387 positive regulation of homophilic cell adhesion; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903681 regulation of epithelial cell-cell adhesion involved in epithelium migration; GO:1903683 positive regulation of epithelial cell-cell adhesion involved in epithelium migration; GO:1903684 regulation of border follicle cell migration; GO:1903688 positive regulation of border follicle cell migration; GO:1903689 regulation of wound healing"," spreading of epidermal cells; GO:1903691 positive regulation of wound healing"," spreading of epidermal cells; GO:1903828 negative regulation of protein localization; GO:1904375 regulation of protein localization to cell periphery; GO:1904376 negative regulation of protein localization to cell periphery; GO:1904892 regulation of receptor signaling pathway via STAT; GO:1904893 negative regulation of receptor signaling pathway via STAT; GO:1905330 regulation of morphogenesis of an epithelium; GO:1905332 positive regulation of morphogenesis of an epithelium; GO:1905475 regulation of protein localization to membrane; GO:1905476 negative regulation of protein localization to membrane; GO:1905879 regulation of oogenesis; GO:1905881 positive regulation of oogenesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000241 regulation of reproductive process; GO:2000243 positive regulation of reproductive process; GO:2000392 regulation of lamellipodium morphogenesis; GO:2000394 positive regulation of lamellipodium morphogenesis; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001046 core promoter sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00096; PF13912; PF13909","PF00096 Zinc finger"," C2H2 type; PF13912 C2H2-type zinc finger; PF13909 C2H2-type zinc-finger domain","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor",null,null,"ADIPOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS"]
["Q92835","Phosphatidylinositol 3",4,"5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2","INPP5D",0.962202949,0.232114822,"nochange",73570.8,69381,68749.9,67907.8,69907,65885.2,1.062645627,1.002128783,0.993013269,0.980850102,1.009726248,0.951635971,"cytoplasm","K03084","SHIP1; phosphatidylinositol-3",4,"5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]","hsa04666 Fc gamma R-mediated phagocytosis; hsa04070 Phosphatidylinositol signaling system; hsa04664 Fc epsilon RI signaling pathway; hsa04662 B cell receptor signaling pathway; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0001501 skeletal system development; GO:0001503 ossification; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001958 endochondral ossification; GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002376 immune system process; GO:0002429 immune response-activating cell surface receptor signaling pathway; GO:0002443 leukocyte mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002757 immune response-activating signal transduction; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0002762 negative regulation of myeloid leukocyte differentiation; GO:0002764 immune response-regulating signaling pathway; GO:0002768 immune response-regulating cell surface receptor signaling pathway; GO:0006066 alcohol metabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0008340 determination of adult lifespan; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010259 multicellular organism aging; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016043 cellular component organization; GO:0016064 immunoglobulin mediated immune response; GO:0016192 vesicle-mediated transport; GO:0016311 dephosphorylation; GO:0016477 cell migration; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0019724 B cell mediated immunity; GO:0019751 polyol metabolic process; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030852 regulation of granulocyte differentiation; GO:0030853 negative regulation of granulocyte differentiation; GO:0030888 regulation of B cell proliferation; GO:0030889 negative regulation of B cell proliferation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032675 regulation of interleukin-6 production; GO:0032715 negative regulation of interleukin-6 production; GO:0032944 regulation of mononuclear cell proliferation; GO:0032945 negative regulation of mononuclear cell proliferation; GO:0034097 response to cytokine; GO:0034103 regulation of tissue remodeling; GO:0034104 negative regulation of tissue remodeling; GO:0035556 intracellular signal transduction; GO:0036075 replacement ossification; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043647 inositol phosphate metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045124 regulation of bone resorption; GO:0045577 regulation of B cell differentiation; GO:0045579 positive regulation of B cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045621 positive regulation of lymphocyte differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045638 negative regulation of myeloid cell differentiation; GO:0045639 positive regulation of myeloid cell differentiation; GO:0045646 regulation of erythrocyte differentiation; GO:0045648 positive regulation of erythrocyte differentiation; GO:0045655 regulation of monocyte differentiation; GO:0045656 negative regulation of monocyte differentiation; GO:0045658 regulation of neutrophil differentiation; GO:0045659 negative regulation of neutrophil differentiation; GO:0045670 regulation of osteoclast differentiation; GO:0045671 negative regulation of osteoclast differentiation; GO:0045779 negative regulation of bone resorption; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046850 regulation of bone remodeling; GO:0046851 negative regulation of bone remodeling; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048705 skeletal system morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048870 cell motility; GO:0050670 regulation of lymphocyte proliferation; GO:0050672 negative regulation of lymphocyte proliferation; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050851 antigen receptor-mediated signaling pathway; GO:0050852 T cell receptor signaling pathway; GO:0050864 regulation of B cell activation; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050869 negative regulation of B cell activation; GO:0050871 positive regulation of B cell activation; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051250 negative regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060348 bone development; GO:0060349 bone morphogenesis; GO:0060350 endochondral bone morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070663 regulation of leukocyte proliferation; GO:0070664 negative regulation of leukocyte proliferation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0097435 supramolecular fiber organization; GO:0098657 import into cell; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1902105 regulation of leukocyte differentiation; GO:1902106 negative regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005938 cell cortex; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030175 filopodium; GO:0030863 cortical cytoskeleton; GO:0031252 cell leading edge; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0098858 actin-based cell projection; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004445 inositol-polyphosphate 5-phosphatase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016312 inositol bisphosphate phosphatase activity; GO:0016314 phosphatidylinositol-3",4,"5-trisphosphate 3-phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding; GO:0030487 inositol-4","5-bisphosphate 5-phosphatase activity; GO:0034485 phosphatidylinositol-3",4,"5-trisphosphate 5-phosphatase activity; GO:0034594 phosphatidylinositol trisphosphate phosphatase activity; GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity; GO:0042169 SH2 domain binding; GO:0042578 phosphoric ester hydrolase activity; GO:0046030 inositol trisphosphate phosphatase activity; GO:0051425 PTB domain binding; GO:0052659 inositol-1",3,4,"5-tetrakisphosphate 5-phosphatase activity; GO:0052743 inositol tetrakisphosphate phosphatase activity; GO:0052745 inositol phosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity;","PF00017; PF03372","PF00017 SH2 domain; PF03372 Endonuclease/Exonuclease/phosphatase family","U","KOG0565","Inositol polyphosphate 5-phosphatase and related proteins","WP23 B CELL RECEPTOR SIGNALING PATHWAY;WP437 EGFEGFR SIGNALING PATHWAY;WP286 IL3 SIGNALING PATHWAY;WP395 IL4 SIGNALING PATHWAY;WP304 KIT RECEPTOR SIGNALING PATHWAY;WP4747 NETRINUNC5B SIGNALING PATHWAY;WP4971 PHOSPHOINOSITIDES METABOLISM;WP3851 TLR4 SIGNALING AND TOLERANCE","http://www.wikipathways.org/instance/WP23_r120701;http://www.wikipathways.org/instance/WP437_r120689;http://www.wikipathways.org/instance/WP286_r120663;http://www.wikipathways.org/instance/WP395_r120704;http://www.wikipathways.org/instance/WP304_r120696;http://www.wikipathways.org/instance/WP4747_r116543;http://www.wikipathways.org/instance/WP4971_r112223;http://www.wikipathways.org/instance/WP3851_r117847",null,"R-HSA-109582 Hemostasis;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1430728 Metabolism;R-HSA-1483249 Inositol phosphate metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660499 Synthesis of PIPs at the plasma membrane;R-HSA-168256 Immune System;R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol;R-HSA-202403 TCR signaling;R-HSA-202424 Downstream TCR signaling;R-HSA-202733 Cell surface interactions at the vascular wall;R-HSA-210990 PECAM1 interactions;R-HSA-449147 Signaling by Interleukins;R-HSA-451927 Interleukin-2 family signaling;R-HSA-512988 Interleukin-3"," Interleukin-5 and GM-CSF signaling;R-HSA-556833 Metabolism of lipids;R-HSA-912526 Interleukin receptor SHC signaling","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483249;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660499;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-1855204;https://reactome.org/PathwayBrowser/#/R-HSA-202403;https://reactome.org/PathwayBrowser/#/R-HSA-202424;https://reactome.org/PathwayBrowser/#/R-HSA-202733;https://reactome.org/PathwayBrowser/#/R-HSA-210990;https://reactome.org/PathwayBrowser/#/R-HSA-449147;https://reactome.org/PathwayBrowser/#/R-HSA-451927;https://reactome.org/PathwayBrowser/#/R-HSA-512988;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-912526"]
["Q92890","Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3","UFD1",0.928036435,0.073855535,"nochange",105155,105205,97120.6,96240.1,96927.3,92185.8,1.064261181,1.064767225,0.982945979,0.974034544,0.980989613,0.933001458,"mitochondria","K14016","UFD1; ubiquitin fusion degradation protein 1","hsa04141 Protein processing in endoplasmic reticulum","GO:0000731 DNA synthesis involved in DNA repair; GO:0001501 skeletal system development; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002698 negative regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0002832 negative regulation of response to biotic stimulus; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006301 postreplication repair; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006515 protein quality control for misfolded or incompletely synthesized proteins; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016579 protein deubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019985 translesion synthesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030970 retrograde protein transport"," ER to cytosol; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032479 regulation of type I interferon production; GO:0032480 negative regulation of type I interferon production; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032527 protein exit from endoplasmic reticulum; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; GO:0039535 regulation of RIG-I signaling pathway; GO:0039536 negative regulation of RIG-I signaling pathway; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045088 regulation of innate immune response; GO:0045184 establishment of protein localization; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050687 negative regulation of defense response to virus; GO:0050688 regulation of defense response to virus; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0051788 response to misfolded protein; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070987 error-free translesion synthesis; GO:0071218 cellular response to misfolded protein; GO:0071310 cellular response to organic substance; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071712 ER-associated misfolded protein catabolic process; GO:0071897 DNA biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:0098586 cellular response to virus; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903513 endoplasmic reticulum to cytosol transport; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process;","GO:0000502 proteasome complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex; GO:0036501 UFD1-NPL4 complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex; GO:1905368 peptidase complex; GO:1905369 endopeptidase complex;","GO:0003824 catalytic activity; GO:0004843 thiol-dependent deubiquitinase; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0016787 hydrolase activity; GO:0019783 ubiquitin-like protein-specific protease activity; GO:0019899 enzyme binding; GO:0031593 polyubiquitin modification-dependent protein binding; GO:0036435 K48-linked polyubiquitin modification-dependent protein binding; GO:0044877 protein-containing complex binding; GO:0051117 ATPase binding; GO:0101005 deubiquitinase activity; GO:0140030 modification-dependent protein binding; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG1816","Ubiquitin fusion-degradation protein","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4657_r120007",null,"R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template;R-HSA-110320 Translesion Synthesis by POLH;R-HSA-2262752 Cellular responses to stress;R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-73893 DNA Damage Bypass;R-HSA-73894 DNA Repair;R-HSA-8951664 Neddylation;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9711123 Cellular response to chemical stress;R-HSA-9755511 KEAP1-NFE2L2 pathway","https://reactome.org/PathwayBrowser/#/R-HSA-110313;https://reactome.org/PathwayBrowser/#/R-HSA-110320;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689880;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73893;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-8951664;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9711123;https://reactome.org/PathwayBrowser/#/R-HSA-9755511"]
["Q92922","SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3","SMARCC1",1.23957015,{"v":1.47153E-5,"d":"1.47E-05"},"up",93491.4,94895,92586,115976,117078,115231,0.891445059,0.904828453,0.882812026,1.105836817,1.11634444,1.098733205,"cytoplasm","K11649","SMARCC; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C","hsa05225 Hepatocellular carcinoma; hsa04714 Thermogenesis","GO:0000003 reproduction; GO:0002009 morphogenesis of an epithelium; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0002165 instar larval or pupal development; GO:0002682 regulation of immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006337 nucleosome disassembly; GO:0006338 chromatin remodeling; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007406 negative regulation of neuroblast proliferation; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007548 sex differentiation; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008285 negative regulation of cell population proliferation; GO:0008286 insulin receptor signaling pathway; GO:0008406 gonad development; GO:0008586 imaginal disc-derived wing vein morphogenesis; GO:0008587 imaginal disc-derived wing margin morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010721 negative regulation of cell development; GO:0010948 negative regulation of cell cycle process; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022411 cellular component disassembly; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031498 chromatin disassembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0032984 protein-containing complex disassembly; GO:0032986 protein-DNA complex disassembly; GO:0034728 nucleosome organization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035262 gonad morphogenesis; GO:0035295 tube development; GO:0040008 regulation of growth; GO:0040009 regulation of growth rate; GO:0040010 positive regulation of growth rate; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0040027 negative regulation of vulval development; GO:0040028 regulation of vulval development; GO:0040035 hermaphrodite genitalia development; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0043434 response to peptide hormone; GO:0043933 protein-containing complex organization; GO:0045088 regulation of innate immune response; GO:0045137 development of primary sexual characteristics; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045786 negative regulation of cell cycle; GO:0045861 negative regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045927 positive regulation of growth; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046662 regulation of oviposition; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048580 regulation of post-embryonic development; GO:0048581 negative regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048608 reproductive structure development; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048806 genitalia development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061062 regulation of nematode larval development; GO:0061064 negative regulation of nematode larval development; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071103 DNA conformation change; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072091 regulation of stem cell proliferation; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902692 regulation of neuroblast proliferation; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902807 negative regulation of cell cycle G1/S phase transition; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000045 regulation of G1/S transition of mitotic cell cycle; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000134 negative regulation of G1/S transition of mitotic cell cycle; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000241 regulation of reproductive process; GO:2000647 negative regulation of stem cell proliferation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0000803 sex chromosome; GO:0001741 XY body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0016514 SWI/SNF complex; GO:0016586 RSC-type complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035060 brahma complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0071564 npBAF complex; GO:0071565 nBAF complex; GO:1902494 catalytic complex; GO:1904949 ATPase complex;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0047485 protein N-terminus binding; GO:0140110 transcription regulator activity;","PF04433; PF00249","PF04433 SWIRM domain; PF00249 Myb-like DNA-binding domain","B","KOG1279","Chromatin remodeling factor subunit and related transcription factors","WP4321 THERMOGENESIS;WP4204 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1","http://www.wikipathways.org/instance/WP4321_r106178;http://www.wikipathways.org/instance/WP4204_r108297","Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-3214858 RMTs methylate histone arginines;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8878171 Transcriptional regulation by RUNX1;R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3214858;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8878171;https://reactome.org/PathwayBrowser/#/R-HSA-8939243","G2M CHECKPOINT;MYC TARGETS V1;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["Q93008","Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4","USP9X",0.789053457,0.002127724,"down",30110.5,27468.7,29767.1,22358,23699.1,22863.8,1.156115935,1.054681981,1.142930826,0.858452702,0.909945273,0.877873284,"plasma membrane","K11840",null,null,"GO:0000003 reproduction; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001701 in utero embryonic development; GO:0001745 compound eye morphogenesis; GO:0001764 neuron migration; GO:0002682 regulation of immune system process; GO:0003002 regionalization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006605 protein targeting; GO:0006625 protein targeting to peroxisome; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007031 peroxisome organization; GO:0007097 nuclear migration; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007179 transforming growth factor beta receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007292 female gamete generation; GO:0007349 cellularization; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008354 germ cell migration; GO:0008583 mystery cell differentiation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009798 axis specification; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009950 dorsal/ventral axis specification; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016192 vesicle-mediated transport; GO:0016477 cell migration; GO:0016579 protein deubiquitination; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0019953 sexual reproduction; GO:0021537 telencephalon development; GO:0021543 pallium development; GO:0021549 cerebellum development; GO:0021575 hindbrain morphogenesis; GO:0021587 cerebellum morphogenesis; GO:0021695 cerebellar cortex development; GO:0021696 cerebellar cortex morphogenesis; GO:0021698 cerebellar cortex structural organization; GO:0021761 limbic system development; GO:0021766 hippocampus development; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030509 BMP signaling pathway; GO:0030900 forebrain development; GO:0030902 hindbrain development; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0035190 syncytial nuclear migration; GO:0035192 nuclear cortical migration; GO:0036211 protein modification process; GO:0040007 growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043574 peroxisomal transport; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045184 establishment of protein localization; GO:0045861 negative regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048532 anatomical structure arrangement; GO:0048583 regulation of response to stimulus; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048592 eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050854 regulation of antigen receptor-mediated signaling pathway; GO:0050856 regulation of T cell receptor signaling pathway; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051647 nucleus localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0060560 developmental growth involved in morphogenesis; GO:0061564 axon development; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071108 protein K48-linked deubiquitination; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071772 response to BMP; GO:0071773 cellular response to BMP stimulus; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072662 protein localization to peroxisome; GO:0072663 establishment of protein localization to peroxisome; GO:0080090 regulation of primary metabolic process; GO:0090596 sensory organ morphogenesis; GO:0098657 import into cell; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901535 regulation of DNA demethylation; GO:1901537 positive regulation of DNA demethylation; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1990138 neuron projection extension; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0045177 apical part of cell; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004197 cysteine-type endopeptidase activity; GO:0004843 thiol-dependent deubiquitinase; GO:0005488 binding; GO:0005515 protein binding; GO:0008233 peptidase activity; GO:0008234 cysteine-type peptidase activity; GO:0016787 hydrolase activity; GO:0019783 ubiquitin-like protein-specific protease activity; GO:0046332 SMAD binding; GO:0070410 co-SMAD binding; GO:0101005 deubiquitinase activity; GO:0140096 catalytic activity"," acting on a protein; GO:1990380 Lys48-specific deubiquitinase activity;",null,null,"O","KOG1866","Ubiquitin carboxyl-terminal hydrolase","WP4803 CILIOPATHIES","http://www.wikipathways.org/instance/WP4803_r110008",null,"R-HSA-162582 Signal Transduction;R-HSA-170834 Signaling by TGF-beta Receptor Complex;R-HSA-194315 Signaling by Rho GTPases;R-HSA-212436 Generic Transcription Pathway;R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer;R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity;R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689880 Ub-specific processing proteases;R-HSA-597592 Post-translational protein modification;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription);R-HSA-8852135 Protein ubiquitination;R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes;R-HSA-9006936 Signaling by TGFB family members;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013420 RHOU GTPase cycle;R-HSA-9013424 RHOV GTPase cycle;R-HSA-9033241 Peroxisomal protein import;R-HSA-9609507 Protein localization;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3;R-HSA-977225 Amyloid fiber formation","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-170834;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-2173793;https://reactome.org/PathwayBrowser/#/R-HSA-2173795;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689880;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160;https://reactome.org/PathwayBrowser/#/R-HSA-8852135;https://reactome.org/PathwayBrowser/#/R-HSA-8866652;https://reactome.org/PathwayBrowser/#/R-HSA-9006936;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013420;https://reactome.org/PathwayBrowser/#/R-HSA-9013424;https://reactome.org/PathwayBrowser/#/R-HSA-9033241;https://reactome.org/PathwayBrowser/#/R-HSA-9609507;https://reactome.org/PathwayBrowser/#/R-HSA-9716542;https://reactome.org/PathwayBrowser/#/R-HSA-977225"]
["Q969J3","BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1","BORCS5",1.135693384,0.012647829,"nochange",8232.5,8751.16,8889.23,9909.77,10026.2,9447.7,0.893921011,0.950239392,0.965231639,1.076046355,1.088688836,1.025872765,"cytoplasm","K20819",null,null,"GO:0000003 reproduction; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0009987 cellular process; GO:0010970 transport along microtubule; GO:0022414 reproductive process; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032418 lysosome localization; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032886 regulation of microtubule-based process; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0043051 regulation of pharyngeal pumping; GO:0045927 positive regulation of growth; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048520 positive regulation of behavior; GO:0048522 positive regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0060259 regulation of feeding behavior; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0060632 regulation of microtubule-based movement; GO:0065007 biological regulation; GO:0072384 organelle transport along microtubule; GO:0099111 microtubule-based transport; GO:1901608 regulation of vesicle transport along microtubule; GO:1901610 positive regulation of vesicle transport along microtubule; GO:1902513 regulation of organelle transport along microtubule; GO:1902803 regulation of synaptic vesicle transport; GO:1902805 positive regulation of synaptic vesicle transport; GO:1903742 regulation of anterograde synaptic vesicle transport; GO:1903744 positive regulation of anterograde synaptic vesicle transport; GO:1903746 positive regulation of pharyngeal pumping; GO:1903998 regulation of eating behavior; GO:1904000 positive regulation of eating behavior; GO:2000253 positive regulation of feeding behavior;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030658 transport vesicle membrane; GO:0030659 cytoplasmic vesicle membrane; GO:0030672 synaptic vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098574 cytoplasmic side of lysosomal membrane; GO:0098588 bounding membrane of organelle; GO:0098793 presynapse; GO:0098852 lytic vacuole membrane; GO:0099078 BORC complex; GO:0099501 exocytic vesicle membrane; GO:0099503 secretory vesicle;",{"$nulls":3},"S","KOG4515","Uncharacterized conserved protein"]
["Q969R8","KICSTOR complex protein ITFG2 OS=Homo sapiens OX=9606 GN=ITFG2 PE=1 SV=1","ITFG2",0.870546624,0.007346599,"down",6411.41,6303.83,6148.54,5440.38,5255.95,5725.47,1.09020342,1.071910395,1.045504708,0.925088379,0.893727693,0.973565405,"cytoplasm","K23296",null,null,"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002285 lymphocyte activation involved in immune response; GO:0002312 B cell activation involved in immune response; GO:0002313 mature B cell differentiation involved in immune response; GO:0002314 germinal center B cell differentiation; GO:0002335 mature B cell differentiation; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002521 leukocyte differentiation; GO:0006950 response to stress; GO:0006955 immune response; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030098 lymphocyte differentiation; GO:0030154 cell differentiation; GO:0030183 B cell differentiation; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032006 regulation of TOR signaling; GO:0032007 negative regulation of TOR signaling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034198 cellular response to amino acid starvation; GO:0042113 B cell activation; GO:0042149 cellular response to glucose starvation; GO:0042594 response to starvation; GO:0045321 leukocyte activation; GO:0046649 lymphocyte activation; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0071496 cellular response to external stimulus; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903432 regulation of TORC1 signaling; GO:1904262 negative regulation of TORC1 signaling; GO:1990928 response to amino acid starvation;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0140007 KICSTOR complex;",{"$nulls":9},"R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9639288 Amino acids regulate mTORC1;R-HSA-9711097 Cellular response to starvation","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9639288;https://reactome.org/PathwayBrowser/#/R-HSA-9711097"]
["Q96A57","Transmembrane protein 230 OS=Homo sapiens OX=9606 GN=TMEM230 PE=1 SV=1","TMEM230",0.578739732,0.009924507,"down",10156,11789.4,11153.9,6871.13,5045.53,7239.22,1.166123626,1.353672497,1.280703655,0.788951067,0.57933357,0.831215585,"plasma membrane",{"$nulls":3},"GO:0006810 transport; GO:0016192 vesicle-mediated transport; GO:0046907 intracellular transport; GO:0048489 synaptic vesicle transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0099003 vesicle-mediated transport in synapse;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045202 synapse; GO:0055037 recycling endosome; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0099503 secretory vesicle;",{"$nulls":3},"S","KOG4753","Predicted membrane protein"]
["Q96AQ8","Mitochondrial calcium uniporter regulator 1 OS=Homo sapiens OX=9606 GN=MCUR1 PE=1 SV=1","MCUR1",1.071850132,0.545625811,"nochange",3720.47,4596.24,5011.31,4328.14,4571.59,5385.91,0.808397728,0.99868833,1.088876303,0.940434553,0.993332286,1.170270801,"nucleus","K22137",null,null,"GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006839 mitochondrial transport; GO:0006851 mitochondrial calcium ion transmembrane transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0009987 cellular process; GO:0019725 cellular homeostasis; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0034220 ion transmembrane transport; GO:0036444 calcium import into the mitochondrion; GO:0042592 homeostatic process; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051560 mitochondrial calcium ion homeostasis; GO:0051561 positive regulation of mitochondrial calcium ion concentration; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0060401 cytosolic calcium ion transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070509 calcium ion import; GO:0070588 calcium ion transmembrane transport; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098771 inorganic ion homeostasis; GO:1990542 mitochondrial transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031304 intrinsic component of mitochondrial inner membrane; GO:0031305 integral component of mitochondrial inner membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098573 intrinsic component of mitochondrial membrane;",{"$nulls":3},"S","KOG3156","Uncharacterized membrane protein"]
["Q96B96","Lipid droplet assembly factor 1 OS=Homo sapiens OX=9606 GN=LDAF1 PE=1 SV=2","LDAF1",0.955426769,0.957142782,"nochange",10871.3,7689.27,5625.92,7120.17,7842.39,8145.86,1.37917167,0.97548806,0.713724162,0.903290016,0.994913406,1.033412686,"plasma membrane"]
["Q96BS2","Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3","TESC",0.695533516,3.02935E-4,"down",23858.6,23983.6,24342.1,16239.2,16197.5,17769.9,1.169626173,1.17575408,1.193328916,0.796098403,0.794054133,0.871138295,"cytoplasm","K17612",null,null,"GO:0000003 reproduction; GO:0001101 response to acid chemical; GO:0002028 regulation of sodium ion transport; GO:0002376 immune system process; GO:0002520 immune system development; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0002763 positive regulation of myeloid leukocyte differentiation; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006807 nitrogen compound metabolic process; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006883 cellular sodium ion homeostasis; GO:0007275 multicellular organism development; GO:0007548 sex differentiation; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0008406 gonad development; GO:0008584 male gonad development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010155 regulation of proton transport; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010765 positive regulation of sodium ion transport; GO:0010959 regulation of metal ion transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0022414 reproductive process; GO:0022898 regulation of transmembrane transporter activity; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030219 megakaryocyte differentiation; GO:0030852 regulation of granulocyte differentiation; GO:0030854 positive regulation of granulocyte differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031647 regulation of protein stability; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032415 regulation of sodium:proton antiporter activity; GO:0032417 positive regulation of sodium:proton antiporter activity; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032526 response to retinoic acid; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033628 regulation of cell adhesion mediated by integrin; GO:0033993 response to lipid; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044238 primary metabolic process; GO:0045137 development of primary sexual characteristics; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045639 positive regulation of myeloid cell differentiation; GO:0045652 regulation of megakaryocyte differentiation; GO:0045654 positive regulation of megakaryocyte differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046546 development of primary male sexual characteristics; GO:0046661 male sex differentiation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048608 reproductive structure development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050821 protein stabilization; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051604 protein maturation; GO:0051641 cellular localization; GO:0051716 cellular response to stimulus; GO:0055065 metal ion homeostasis; GO:0055067 monovalent inorganic cation homeostasis; GO:0055078 sodium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0061458 reproductive system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071229 cellular response to acid chemical; GO:0071300 cellular response to retinoic acid; GO:0071310 cellular response to organic substance; GO:0071396 cellular response to lipid; GO:0071704 organic substance metabolic process; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0098771 inorganic ion homeostasis; GO:1901564 organonitrogen compound metabolic process; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902105 regulation of leukocyte differentiation; GO:1902107 positive regulation of leukocyte differentiation; GO:1902305 regulation of sodium ion transmembrane transport; GO:1902307 positive regulation of sodium ion transmembrane transport; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2000651 positive regulation of sodium ion transmembrane transporter activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0031252 cell leading edge; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0120025 plasma membrane bounded cell projection;","GO:0000287 magnesium ion binding; GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0019208 phosphatase regulator activity; GO:0019212 phosphatase inhibitor activity; GO:0030234 enzyme regulator activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046983 protein dimerization activity; GO:0098772 molecular function regulator;",null,null,"T","KOG0034","Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B)"," EF-Hand superfamily protein"]
["Q96C00","Zinc finger and BTB domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ZBTB9 PE=1 SV=1","ZBTB9",0.71528054,0.145289595,"nochange",1340.67,1934.08,1698.7,1202.13,1495.15,860.132,0.942931676,1.360293954,1.194744447,0.845492519,1.051581892,0.604955513,"nucleus","K10496",{"$nulls":5},"PF00651","PF00651 BTB/POZ domain","R","KOG1721","FOG: Zn-finger"]
["Q96CB9","5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2","NSUN4",0.843638649,0.008410675,"down",15174.3,14473.7,15535.8,13417.7,12210.7,12490.4,1.092952681,1.042490871,1.118990284,0.96643082,0.879494758,0.899640587,"nucleus","K21970",null,null,"GO:0000154 rRNA modification; GO:0001510 RNA methylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0031167 rRNA methylation; GO:0032259 methylation; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0000313 organellar ribosome; GO:0000315 organellar large ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005762 mitochondrial large ribosomal subunit; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003824 catalytic activity; GO:0008168 methyltransferase activity; GO:0008169 C-methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008649 rRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity; GO:0016434 rRNA (cytosine) methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0140098 catalytic activity"," acting on RNA; GO:0140102 catalytic activity"," acting on a rRNA;",null,null,"J","KOG2198","tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily",{"$nulls":3},"R-HSA-6793080 rRNA modification in the mitochondrion;R-HSA-72312 rRNA processing;R-HSA-8868766 rRNA processing in the mitochondrion;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6793080;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868766;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q96D31","Calcium release-activated calcium channel protein 1 OS=Homo sapiens OX=9606 GN=ORAI1 PE=1 SV=2","ORAI1",1.205924967,0.133204328,"nochange",6703.15,5663.87,4770.29,7327.81,6829.54,6508.96,1.063890178,0.898940895,0.757116382,1.163033064,1.083950161,1.03306932,"plasma membrane","K16056","ORAI1; calcium release-activated calcium channel protein 1","hsa04020 Calcium signaling pathway; hsa04024 cAMP signaling pathway; hsa04927 Cortisol synthesis and secretion; hsa04924 Renin secretion; hsa04934 Cushing syndrome; hsa04611 Platelet activation; hsa05340 Primary immunodeficiency; hsa04925 Aldosterone synthesis and secretion","GO:0002115 store-operated calcium entry; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007275 multicellular organism development; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010927 cellular component assembly involved in morphogenesis; GO:0010959 regulation of metal ion transport; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0030001 metal ion transport; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030239 myofibril assembly; GO:0030879 mammary gland development; GO:0031032 actomyosin structure organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0034220 ion transmembrane transport; GO:0042692 muscle cell differentiation; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0044085 cellular component biogenesis; GO:0045214 sarcomere organization; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051146 striated muscle cell differentiation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051924 regulation of calcium ion transport; GO:0051928 positive regulation of calcium ion transport; GO:0055001 muscle cell development; GO:0055002 striated muscle cell development; GO:0055085 transmembrane transport; GO:0060429 epithelium development; GO:0061061 muscle structure development; GO:0061180 mammary gland epithelium development; GO:0065007 biological regulation; GO:0070509 calcium ion import; GO:0070588 calcium ion transmembrane transport; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0097435 supramolecular fiber organization; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016323 basolateral plasma membrane; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0071944 cell periphery; GO:0098590 plasma membrane region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005261 cation channel activity; GO:0005262 calcium channel activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015085 calcium ion transmembrane transporter activity; GO:0015267 channel activity; GO:0015279 store-operated calcium channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022803 passive transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0042802 identical protein binding; GO:0046873 metal ion transmembrane transporter activity;",null,null,"A","KOG4298","CAP-binding protein complex interacting protein 2",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-1280218 Adaptive Immune System;R-HSA-139853 Elevation of cytosolic Ca2+ levels;R-HSA-168256 Immune System;R-HSA-397014 Muscle contraction;R-HSA-418346 Platelet homeostasis;R-HSA-418360 Platelet calcium homeostasis;R-HSA-5576891 Cardiac conduction;R-HSA-5578775 Ion homeostasis;R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;R-HSA-983705 Signaling by the B Cell Receptor (BCR)","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-139853;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-397014;https://reactome.org/PathwayBrowser/#/R-HSA-418346;https://reactome.org/PathwayBrowser/#/R-HSA-418360;https://reactome.org/PathwayBrowser/#/R-HSA-5576891;https://reactome.org/PathwayBrowser/#/R-HSA-5578775;https://reactome.org/PathwayBrowser/#/R-HSA-983695;https://reactome.org/PathwayBrowser/#/R-HSA-983705"]
["Q96DZ1","Endoplasmic reticulum lectin 1 OS=Homo sapiens OX=9606 GN=ERLEC1 PE=1 SV=1","ERLEC1",0.76375911,0.122761139,"nochange",14924.4,16327.3,11297.2,12095.4,11092.9,9308.81,1.193219999,1.305383191,0.903221903,0.967038754,0.886887924,0.744248229,"extracellular","K14008","ERLEC1; endoplasmic reticulum lectin 1","hsa04141 Protein processing in endoplasmic reticulum","GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0030970 retrograde protein transport"," ER to cytosol; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032527 protein exit from endoplasmic reticulum; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034976 response to endoplasmic reticulum stress; GO:0036503 ERAD pathway; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0045861 negative regulation of proteolysis; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070861 regulation of protein exit from endoplasmic reticulum; GO:0070862 negative regulation of protein exit from endoplasmic reticulum; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0090317 negative regulation of intracellular protein transport; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903513 endoplasmic reticulum to cytosol transport; GO:1903573 negative regulation of response to endoplasmic reticulum stress; GO:1903828 negative regulation of protein localization; GO:1904152 regulation of retrograde protein transport"," ER to cytosol; GO:1904153 negative regulation of retrograde protein transport"," ER to cytosol; GO:1904292 regulation of ERAD pathway; GO:1904293 negative regulation of ERAD pathway; GO:1904950 negative regulation of establishment of protein localization; GO:1905897 regulation of response to endoplasmic reticulum stress;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044322 endoplasmic reticulum quality control compartment; GO:0070013 intracellular organelle lumen;","GO:0005488 binding; GO:0005515 protein binding; GO:0051082 unfolded protein binding;",null,null,"R","KOG3394","Protein OS-9",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5678895 Defective CFTR causes cystic fibrosis","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-382556;https://reactome.org/PathwayBrowser/#/R-HSA-5358346;https://reactome.org/PathwayBrowser/#/R-HSA-5358351;https://reactome.org/PathwayBrowser/#/R-HSA-5362768;https://reactome.org/PathwayBrowser/#/R-HSA-5387390;https://reactome.org/PathwayBrowser/#/R-HSA-5619084;https://reactome.org/PathwayBrowser/#/R-HSA-5619115;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-5678895"]
["Q96EE3","Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3","SEH1L",0.762440196,0.000564872,"down",35109.1,36650.8,36385.5,28767.8,27097.8,26588.8,1.105219418,1.153751473,1.145399943,0.905598012,0.853027128,0.837004026,"nucleus","K14299","SEH1; nucleoporin SEH1","hsa04150 mTOR signaling pathway; hsa03013 Nucleocytoplasmic transport; hsa05014 Amyotrophic lateral sclerosis","GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0001816 cytokine production; GO:0002532 production of molecular mediator involved in inflammatory response; GO:0002534 cytokine production involved in inflammatory response; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006999 nuclear pore organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007080 mitotic metaphase plate congression; GO:0007154 cell communication; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008608 attachment of spindle microtubules to kinetochore; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010467 gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031503 protein-containing complex localization; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032006 regulation of TOR signaling; GO:0032008 positive regulation of TOR signaling; GO:0032501 multicellular organismal process; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0034198 cellular response to amino acid starvation; GO:0034613 cellular protein localization; GO:0042594 response to starvation; GO:0042742 defense response to bacterium; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043933 protein-containing complex organization; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050000 chromosome localization; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050830 defense response to Gram-positive bacterium; GO:0050896 response to stimulus; GO:0051028 mRNA transport; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051276 chromosome organization; GO:0051303 establishment of chromosome localization; GO:0051310 metaphase plate congression; GO:0051315 attachment of mitotic spindle microtubules to kinetochore; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071496 cellular response to external stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0098542 defense response to other organism; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1903047 mitotic cell cycle process; GO:1903432 regulation of TORC1 signaling; GO:1904263 positive regulation of TORC1 signaling; GO:1990928 response to amino acid starvation;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031080 nuclear pore outer ring; GO:0031090 organelle membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0035859 Seh1-associated complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0061700 GATOR2 complex; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane;",{"$nulls":3},"YU","KOG2445","Nuclear pore complex component (sc Seh1)",{"$nulls":3},"R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9639288 Amino acids regulate mTORC1;R-HSA-9711097 Cellular response to starvation","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9639288;https://reactome.org/PathwayBrowser/#/R-HSA-9711097"]
["Q96EP5","DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1","DAZAP1",0.771242591,0.001470237,"down",28683,31734.3,28900.9,22868.3,22743.4,23274.3,1.087821942,1.203544533,1.096085945,0.867295559,0.862558643,0.88269338,"nucleus","K14411","MSI; RNA-binding protein Musashi","hsa03015 mRNA surveillance pathway","GO:0000003 reproduction; GO:0000578 embryonic axis specification; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001667 ameboidal-type cell migration; GO:0001890 placenta development; GO:0001893 maternal placenta development; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006403 RNA localization; GO:0006417 regulation of translation; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0007028 cytoplasm organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007316 pole plasm RNA localization; GO:0007319 negative regulation of oskar mRNA translation; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007565 female pregnancy; GO:0008283 cell population proliferation; GO:0008298 intracellular mRNA localization; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010631 epithelial cell migration; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0017148 negative regulation of translation; GO:0019094 pole plasm mRNA localization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030707 ovarian follicle cell development; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033120 positive regulation of RNA splicing; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034250 positive regulation of cellular amide metabolic process; GO:0035282 segmentation; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042330 taxis; GO:0043484 regulation of RNA splicing; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045451 pole plasm oskar mRNA localization; GO:0045727 positive regulation of translation; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046011 regulation of oskar mRNA translation; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048026 positive regulation of mRNA splicing"," via spliceosome; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048599 oocyte development; GO:0048608 reproductive structure development; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050684 regulation of mRNA processing; GO:0050685 positive regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051674 localization of cell; GO:0060135 maternal process involved in female pregnancy; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0061458 reproductive system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097485 neuron projection guidance; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1903311 regulation of mRNA metabolic process; GO:1903313 positive regulation of mRNA metabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043186 P granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045495 pole plasm; GO:0060293 germ plasm; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003697 single-stranded DNA binding; GO:0003723 RNA binding; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0003730 mRNA 3'-UTR binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008187 poly-pyrimidine tract binding; GO:0008266 poly(U) RNA binding; GO:0034046 poly(G) binding; GO:0035613 RNA stem-loop binding; GO:0048027 mRNA 5'-UTR binding; GO:0070717 poly-purine tract binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","A","KOG4205","RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex"," subunit HRP1"]
["Q96EW2","HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1","HSPBAP1",1.133717932,0.9371731,"nochange",569.736,422.295,"NA",710.197,716.675,260.153,1.063314839,0.78814142,"NA",1.325461282,1.337551361,0.485531098,"cytoplasm","K19375",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;",null,"PF13621","PF13621 Cupin-like domain","BT","KOG2132","Uncharacterized conserved protein"," contains JmjC domain"]
["Q96FZ7","Charged multivesicular body protein 6 OS=Homo sapiens OX=9606 GN=CHMP6 PE=1 SV=3","CHMP6",0.924201029,0.619411627,"nochange",9056.65,7591.57,11023,7135.42,9582.55,8855.8,1.020563625,0.855468655,1.242145036,0.804066636,1.079825539,0.99793051,"nucleus","K12195","CHMP6; charged multivesicular body protein 6","hsa03250 Viral life cycle - HIV-1; hsa04217 Necroptosis; hsa04144 Endocytosis","GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0000920 septum digestion after cytokinesis; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006914 autophagy; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007032 endosome organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007080 mitotic metaphase plate congression; GO:0007175 negative regulation of epidermal growth factor-activated receptor activity; GO:0007176 regulation of epidermal growth factor-activated receptor activity; GO:0008152 metabolic process; GO:0008593 regulation of Notch signaling pathway; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010469 regulation of signaling receptor activity; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0019058 viral life cycle; GO:0019068 virion assembly; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030163 protein catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032509 endosome transport via multivesicular body sorting pathway; GO:0033673 negative regulation of kinase activity; GO:0036257 multivesicular body organization; GO:0036258 multivesicular body assembly; GO:0039702 viral budding via host ESCRT complex; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; GO:0043170 macromolecule metabolic process; GO:0043549 regulation of kinase activity; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046755 viral budding; GO:0046907 intracellular transport; GO:0048285 organelle fission; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050000 chromosome localization; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051303 establishment of chromosome localization; GO:0051310 metaphase plate congression; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0060255 regulation of macromolecule metabolic process; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061099 negative regulation of protein tyrosine kinase activity; GO:0061919 process utilizing autophagic mechanism; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071985 multivesicular body sorting pathway; GO:0080090 regulation of primary metabolic process; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1903047 mitotic cell cycle process; GO:1904895 ESCRT complex assembly; GO:1904902 ESCRT III complex assembly; GO:2000272 negative regulation of signaling receptor activity;","GO:0000815 ESCRT III complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036452 ESCRT complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0044877 protein-containing complex binding; GO:0047485 protein N-terminus binding;",null,null,"R","KOG2910","Uncharacterized conserved protein predicted to be involved in protein sorting","WP4313 FERROPTOSIS","http://www.wikipathways.org/instance/WP4313_r120500",null,"R-HSA-162587 HIV Life Cycle;R-HSA-162588 Budding and maturation of HIV virion;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1632852 Macroautophagy;R-HSA-1640170 Cell Cycle;R-HSA-1643685 Disease;R-HSA-199991 Membrane Trafficking;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2995410 Nuclear Envelope (NE) Reassembly;R-HSA-5218859 Regulated Necrosis;R-HSA-5357801 Programmed Cell Death;R-HSA-5620971 Pyroptosis;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT);R-HSA-9609646 HCMV Infection;R-HSA-9610379 HCMV Late Events;R-HSA-9612973 Autophagy;R-HSA-9615710 Late endosomal microautophagy;R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III;R-HSA-9678108 SARS-CoV-1 Infection;R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex;R-HSA-9772572 Early SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162588;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-2995410;https://reactome.org/PathwayBrowser/#/R-HSA-5218859;https://reactome.org/PathwayBrowser/#/R-HSA-5357801;https://reactome.org/PathwayBrowser/#/R-HSA-5620971;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-917729;https://reactome.org/PathwayBrowser/#/R-HSA-9609646;https://reactome.org/PathwayBrowser/#/R-HSA-9610379;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9615710;https://reactome.org/PathwayBrowser/#/R-HSA-9668328;https://reactome.org/PathwayBrowser/#/R-HSA-9678108;https://reactome.org/PathwayBrowser/#/R-HSA-9679504;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694676;https://reactome.org/PathwayBrowser/#/R-HSA-9772572"]
["Q96GM8","Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1","TOE1",0.867835279,0.056311993,"nochange",56615.3,51157.4,48013.2,46954.9,44530.6,43711,1.167396379,1.054855551,0.990022764,0.968200826,0.918212236,0.901312244,"nucleus","K13202",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016070 RNA metabolic process; GO:0016073 snRNA metabolic process; GO:0016180 snRNA processing; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031123 RNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0034470 ncRNA processing; GO:0034472 snRNA 3'-end processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0043628 ncRNA 3'-end processing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090503 RNA phosphodiester bond hydrolysis"," exonucleolytic; GO:1901360 organic cyclic compound metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0015030 Cajal body; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000175 3'-5'-exoribonuclease activity; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003700 DNA-binding transcription factor activity; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004527 exonuclease activity; GO:0004532 exoribonuclease activity; GO:0004535 poly(A)-specific ribonuclease activity; GO:0004540 ribonuclease activity; GO:0005488 binding; GO:0008408 3'-5' exonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016796 exonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; GO:0016896 exoribonuclease activity"," producing 5'-phosphomonoesters; GO:0017069 snRNA binding; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"L","KOG1990","Poly(A)-specific exoribonuclease PARN"]
["Q96GW9","Methionine--tRNA ligase"," mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2","MARS2",1.155685515,0.020251706,"nochange",26622.9,28613.2,28396.6,33981.3,30505.6,32166.2,0.886023192,0.952261354,0.945052799,1.130914359,1.015241356,1.07050694,"mitochondria","K01874","MARS; methionyl-tRNA synthetase [EC:6.1.1.10]","hsa00450 Selenocompound metabolism; hsa00970 Aminoacyl-tRNA biosynthesis; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006431 methionyl-tRNA aminoacylation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004812 aminoacyl-tRNA ligase activity; GO:0004825 methionine-tRNA ligase activity; GO:0016874 ligase activity; GO:0016875 ligase activity"," forming carbon-oxygen bonds; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF19303","PF19303 Anticodon binding domain of methionyl tRNA ligase","J","KOG0436","Methionyl-tRNA synthetase","WP3925 AMINO ACID METABOLISM","http://www.wikipathways.org/instance/WP3925_r117062",null,"R-HSA-379724 tRNA Aminoacylation;R-HSA-379726 Mitochondrial tRNA aminoacylation;R-HSA-392499 Metabolism of proteins;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-379724;https://reactome.org/PathwayBrowser/#/R-HSA-379726;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q96HY6","DDRGK domain-containing protein 1 OS=Homo sapiens OX=9606 GN=DDRGK1 PE=1 SV=2","DDRGK1",0.963869297,0.622203863,"nochange",8468.19,8738.43,8939.01,7183.24,8671.9,9345.83,0.989532705,1.021111038,1.044549396,0.839382549,1.013336813,1.092087499,"extracellular","K23344",null,null,"GO:0001501 skeletal system development; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010952 positive regulation of peptidase activity; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030162 regulation of proteolysis; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033146 regulation of intracellular estrogen receptor signaling pathway; GO:0033554 cellular response to stress; GO:0034976 response to endoplasmic reticulum stress; GO:0036211 protein modification process; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043388 positive regulation of DNA binding; GO:0043412 macromolecule modification; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045732 positive regulation of protein catabolic process; GO:0045787 positive regulation of cell cycle; GO:0045862 positive regulation of proteolysis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051101 regulation of DNA binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051216 cartilage development; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0052547 regulation of peptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060548 negative regulation of cell death; GO:0061136 regulation of proteasomal protein catabolic process; GO:0061448 connective tissue development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070647 protein modification by small protein conjugation or removal; GO:0071569 protein ufmylation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090068 positive regulation of cell cycle process; GO:1901564 organonitrogen compound metabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901989 positive regulation of cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902806 regulation of cell cycle G1/S phase transition; GO:1902808 positive regulation of cell cycle G1/S phase transition; GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903719 regulation of I-kappaB phosphorylation; GO:1903721 positive regulation of I-kappaB phosphorylation; GO:1903829 positive regulation of protein localization; GO:1905048 regulation of metallopeptidase activity; GO:1905050 positive regulation of metallopeptidase activity; GO:1905550 regulation of protein localization to endoplasmic reticulum; GO:1905552 positive regulation of protein localization to endoplasmic reticulum; GO:1905636 positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding; GO:1990564 protein polyufmylation; GO:1990592 protein K69-linked ufmylation; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000677 regulation of transcription regulatory region DNA binding; GO:2000679 positive regulation of transcription regulatory region DNA binding; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098827 endoplasmic reticulum subcompartment;","GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0019899 enzyme binding; GO:0044389 ubiquitin-like protein ligase binding;",null,null,"S","KOG3054","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9012999 RHO GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q96I59","Probable asparagine--tRNA ligase"," mitochondrial OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3","NARS2",0.976526517,0.346261515,"nochange",30788.7,31339.1,31100.8,30749.6,31242.9,29047.7,1.002514804,1.020436449,1.012677133,1.001241664,1.017304069,0.94582588,"mitochondria","K01893","NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]","hsa00970 Aminoacyl-tRNA biosynthesis","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006421 asparaginyl-tRNA aminoacylation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004812 aminoacyl-tRNA ligase activity; GO:0004816 asparagine-tRNA ligase activity; GO:0016874 ligase activity; GO:0016875 ligase activity"," forming carbon-oxygen bonds; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF01336; PF00152","PF01336 OB-fold nucleic acid binding domain; PF00152 tRNA synthetases class II (D"," K and N) ","J","KOG0554","Asparaginyl-tRNA synthetase (mitochondrial)","WP2858 ECTODERM DIFFERENTIATION","http://www.wikipathways.org/instance/WP2858_r116763",null,"R-HSA-379724 tRNA Aminoacylation;R-HSA-379726 Mitochondrial tRNA aminoacylation;R-HSA-392499 Metabolism of proteins;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-379724;https://reactome.org/PathwayBrowser/#/R-HSA-379726;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q96JA1","Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Homo sapiens OX=9606 GN=LRIG1 PE=1 SV=2","LRIG1",1.285566873,0.324523187,"nochange",3894.33,3783.5,3214.82,3586.45,3914.45,6502.33,0.938548065,0.911837621,0.774783619,0.864347836,0.94339706,1.567085799,"extracellular","K24610",null,null,"GO:0003008 system process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007179 transforming growth factor beta receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009790 embryo development; GO:0009887 animal organ morphogenesis; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010453 regulation of cell fate commitment; GO:0010470 regulation of gastrulation; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0021675 nerve development; GO:0022404 molting cycle process; GO:0022405 hair cycle process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway; GO:0032474 otolith morphogenesis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0040018 positive regulation of multicellular organism growth; GO:0042221 response to chemical; GO:0042303 molting cycle; GO:0042471 ear morphogenesis; GO:0042472 inner ear morphogenesis; GO:0042633 hair cycle; GO:0042659 regulation of cell fate specification; GO:0042661 regulation of mesodermal cell fate specification; GO:0043583 ear development; GO:0045595 regulation of cell differentiation; GO:0045927 positive regulation of growth; GO:0045995 regulation of embryonic development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048562 embryonic organ morphogenesis; GO:0048568 embryonic organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048638 regulation of developmental growth; GO:0048639 positive regulation of developmental growth; GO:0048731 system development; GO:0048839 inner ear development; GO:0048840 otolith development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050954 sensory perception of mechanical stimulus; GO:0051094 positive regulation of developmental process; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051716 cellular response to stimulus; GO:0060384 innervation; GO:0065007 biological regulation; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090596 sensory organ morphogenesis; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus; GO:1905770 regulation of mesodermal cell differentiation; GO:1905902 regulation of mesoderm formation; GO:2000026 regulation of multicellular organismal development; GO:2000027 regulation of animal organ morphogenesis; GO:2000380 regulation of mesoderm development;","GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0071944 cell periphery;","GO:0005102 signaling receptor binding; GO:0005114 type II transforming growth factor beta receptor binding; GO:0005126 cytokine receptor binding; GO:0005160 transforming growth factor beta receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0034713 type I transforming growth factor beta receptor binding;","PF13927; PF07679","PF13927 Immunoglobulin domain; PF07679 Immunoglobulin I-set domain","T","KOG4194","Membrane glycoprotein LIG-1","WP2840 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION PART 3 OF 3","http://www.wikipathways.org/instance/WP2840_r117745",null,"R-HSA-162582 Signal Transduction;R-HSA-177929 Signaling by EGFR;R-HSA-6806834 Signaling by MET;R-HSA-6807004 Negative regulation of MET activity;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-177929;https://reactome.org/PathwayBrowser/#/R-HSA-6806834;https://reactome.org/PathwayBrowser/#/R-HSA-6807004;https://reactome.org/PathwayBrowser/#/R-HSA-9006934","ESTROGEN RESPONSE EARLY;IL2 STAT5 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING"]
["Q96K12","Fatty acyl-CoA reductase 2 OS=Homo sapiens OX=9606 GN=FAR2 PE=1 SV=1","FAR2",0.467904894,0.013729433,"nochange",8283.09,6194.96,7677.82,4631.05,2691.75,3044.04,1.528118044,1.142886309,1.416453918,0.854366072,0.496591459,0.561584198,"cytoplasm","K13356","FAR; alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84]","hsa04146 Peroxisome","GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0010025 wax biosynthetic process; GO:0010166 wax metabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0035336 long-chain fatty-acyl-CoA metabolic process; GO:0035337 fatty-acyl-CoA metabolic process; GO:0035383 thioester metabolic process; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0005778 peroxisomal membrane; GO:0005779 integral component of peroxisomal membrane; GO:0005782 peroxisomal matrix; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031231 intrinsic component of peroxisomal membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031903 microbody membrane; GO:0031907 microbody lumen; GO:0031974 membrane-enclosed lumen; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098588 bounding membrane of organelle;","GO:0003824 catalytic activity; GO:0016491 oxidoreductase activity; GO:0016620 oxidoreductase activity"," acting on the aldehyde or oxo group of donors"," NAD or NADP as acceptor; GO:0016903 oxidoreductase activity"," acting on the aldehyde or oxo group of donors; GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity;",null,null,"I","KOG1221","Acyl-CoA reductase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-8848584 Wax and plasmalogen biosynthesis;R-HSA-9640463 Wax biosynthesis","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-8848584;https://reactome.org/PathwayBrowser/#/R-HSA-9640463"]
["Q96KB5","Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3","PBK",0.935298478,0.223295116,"nochange",27858.8,26855.3,27030.5,26446.9,26827,23181.7,1.05659032,1.01853095,1.025175695,1.003041715,1.017457626,0.879203693,"cytoplasm","K08865",null,null,"GO:0000278 mitotic cell cycle; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007049 cell cycle; GO:0008152 metabolic process; GO:0009314 response to radiation; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016310 phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018107 peptidyl-threonine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0018210 peptidyl-threonine modification; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0034644 cellular response to UV; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045861 negative regulation of proteolysis; GO:0045936 negative regulation of phosphate metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050727 regulation of inflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0104004 cellular response to environmental stimulus; GO:1901564 organonitrogen compound metabolic process; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0140096 catalytic activity"," acting on a protein;","PF00069","PF00069 Protein kinase domain","T","KOG0192","Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs","WP3879 4HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3879_r120671;http://www.wikipathways.org/instance/WP3888_r116782",{"$nulls":3},"G2M CHECKPOINT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_G2M_CHECKPOINT"]
["Q96LL4","Uncharacterized protein C8orf48 OS=Homo sapiens OX=9606 GN=C8orf48 PE=1 SV=2","C8orf48",1.251617423,0.271728322,"nochange",2145.62,2555.81,2578.67,2220.61,3223.09,3668.2,0.785366032,0.935508785,0.943876281,0.812814788,1.179754758,1.342679356,"nucleus"]
["Q96MG7","Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1","NSMCE3",0.844007902,0.186156575,"nochange",6578.06,5332.55,4972.04,4833.72,4215.1,5200.27,1.267785225,1.027738893,0.958258035,0.931599711,0.812373481,1.002244654,"cytoplasm","K22823",null,null,"GO:0000003 reproduction; GO:0002576 platelet degranulation; GO:0003008 system process; GO:0003014 renal system process; GO:0003096 renal sodium ion transport; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006355 regulation of transcription"," DNA-templated; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006814 sodium ion transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007406 negative regulation of neuroblast proliferation; GO:0007565 female pregnancy; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009314 response to radiation; GO:0009410 response to xenobiotic stimulus; GO:0009411 response to UV; GO:0009416 response to light stimulus; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010721 negative regulation of cell development; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0030001 metal ion transport; GO:0030154 cell differentiation; GO:0031000 response to caffeine; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034644 cellular response to UV; GO:0036270 response to diuretic; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043279 response to alkaloid; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045055 regulated exocytosis; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070293 renal absorption; GO:0070294 renal sodium ion absorption; GO:0070887 cellular response to chemical stimulus; GO:0071214 cellular response to abiotic stimulus; GO:0071241 cellular response to inorganic substance; GO:0071478 cellular response to radiation; GO:0071482 cellular response to light stimulus; GO:0071704 organic substance metabolic process; GO:0072091 regulation of stem cell proliferation; GO:0072710 response to hydroxyurea; GO:0072711 cellular response to hydroxyurea; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097327 response to antineoplastic agent; GO:0097329 response to antimetabolite; GO:0104004 cellular response to environmental stimulus; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1902692 regulation of neuroblast proliferation; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000647 negative regulation of stem cell proliferation; GO:2001141 regulation of RNA biosynthetic process;","GO:0000793 condensed chromosome; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0030915 Smc5-Smc6 complex; GO:0031091 platelet alpha granule; GO:0031093 platelet alpha granule lumen; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0106068 SUMO ligase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0046983 protein dimerization activity;",null,null,"S","KOG4562","Uncharacterized conserved protein (tumor-rejection antigen MAGE in humans)",{"$nulls":3},"R-HSA-2990846 SUMOylation;R-HSA-3108214 SUMOylation of DNA damage response and repair proteins;R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-2990846;https://reactome.org/PathwayBrowser/#/R-HSA-3108214;https://reactome.org/PathwayBrowser/#/R-HSA-3108232;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q96P48","Arf-GAP with Rho-GAP domain"," ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3","ARAP1",0.788630882,0.021316727,"nochange",25526.3,25003.7,23602.4,17184.6,20525.5,20753,1.155075398,1.131427537,1.068018145,0.7776101,0.928787176,0.939081643,"cytoplasm","nucleus","K18439","ARAP1; Arf-GAP with Rho-GAP domain"," ANK repeat and PH domain-containing protein 1","hsa04144 Endocytosis","GO:0001919 regulation of receptor recycling; GO:0001921 positive regulation of receptor recycling; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006810 transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007049 cell cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007179 transforming growth factor beta receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007444 imaginal disc development; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008360 regulation of cell shape; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030037 actin filament reorganization involved in cell cycle; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031532 actin cytoskeleton reorganization; GO:0032231 regulation of actin filament bundle assembly; GO:0032232 negative regulation of actin filament bundle assembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0035023 regulation of Rho protein signal transduction; GO:0035024 negative regulation of Rho protein signal transduction; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035218 leg disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042221 response to chemical; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046578 regulation of Ras protein signal transduction; GO:0046580 negative regulation of Ras protein signal transduction; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051058 negative regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051497 negative regulation of stress fiber assembly; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060395 SMAD protein signal transduction; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060562 epithelial tube morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071559 response to transforming growth factor beta; GO:0071560 cellular response to transforming growth factor beta stimulus; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090527 actin filament reorganization; GO:0097435 supramolecular fiber organization; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901184 regulation of ERBB signaling pathway; GO:1901186 positive regulation of ERBB signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility; GO:2001141 regulation of RNA biosynthetic process;","GO:0000139 Golgi membrane; GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0032580 Golgi cisterna membrane; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0120025 plasma membrane bounded cell projection;","GO:0001067 transcription regulatory region nucleic acid binding; GO:0001664 G protein-coupled receptor binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005096 GTPase activator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008047 enzyme activator activity; GO:0008134 transcription factor binding; GO:0008289 lipid binding; GO:0030234 enzyme regulator activity; GO:0030695 GTPase regulator activity; GO:0031701 angiotensin receptor binding; GO:0031702 type 1 angiotensin receptor binding; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043325 phosphatidylinositol-3","4-bisphosphate binding; GO:0046332 SMAD binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0070412 R-SMAD binding; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00536; PF00169; PF01412; PF00620; PF00788","PF00536 SAM domain (Sterile alpha motif); PF00169 PH domain; PF01412 Putative GTPase activating protein for Arf; PF00620 RhoGAP domain; PF00788 Ras association (RalGDS/AF-6) domain","TZ","KOG1117","Rho- and Arf-GTPase activating protein ARAP3",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-8848021 Signaling by PTK6;R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1;R-HSA-8980692 RHOA GTPase cycle;R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-8848021;https://reactome.org/PathwayBrowser/#/R-HSA-8849469;https://reactome.org/PathwayBrowser/#/R-HSA-8980692;https://reactome.org/PathwayBrowser/#/R-HSA-9006927;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q96PL5","Erythroid membrane-associated protein OS=Homo sapiens OX=9606 GN=ERMAP PE=1 SV=1","ERMAP",0.611374263,0.16500244,"nochange",2095.86,4373.75,3053.82,1340.67,2583.72,1897.99,0.819452346,1.71007591,1.19400149,0.524183474,1.010198875,0.742087905,"extracellular","K06712",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle;",null,"PF07686","PF07686 Immunoglobulin V-set domain","O","KOG2177","Predicted E3 ubiquitin ligase",{"$nulls":5},"HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["Q96Q42","Alsin OS=Homo sapiens OX=9606 GN=ALS2 PE=1 SV=2","ALS2",1.086710018,0.035412391,"nochange",9007.07,9622.2,8810.12,9944.66,9862,10012,0.943839687,1.008298396,0.923201541,1.04208858,1.033426741,1.049145055,"nucleus","K04575","ALS2; amyotrophic lateral sclerosis 2 protein","hsa05022 Pathways of neurodegeneration - multiple diseases; hsa05014 Amyotrophic lateral sclerosis","GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001662 behavioral fear response; GO:0001701 in utero embryonic development; GO:0001881 receptor recycling; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002209 behavioral defense response; GO:0002252 immune effector process; GO:0002376 immune system process; GO:0006582 melanin metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007528 neuromuscular junction development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016601 Rac protein signal transduction; GO:0018958 phenol-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019748 secondary metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032483 regulation of Rab protein signal transduction; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033555 multicellular organismal response to stress; GO:0033674 positive regulation of kinase activity; GO:0035006 melanization defense response; GO:0035010 encapsulation of foreign target; GO:0035011 melanotic encapsulation of foreign target; GO:0035020 regulation of Rac protein signal transduction; GO:0035022 positive regulation of Rac protein signal transduction; GO:0035249 synaptic transmission"," glutamatergic; GO:0035556 intracellular signal transduction; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042440 pigment metabolic process; GO:0042596 fear response; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043112 receptor metabolic process; GO:0043170 macromolecule metabolic process; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0045087 innate immune response; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046578 regulation of Ras protein signal transduction; GO:0046579 positive regulation of Ras protein signal transduction; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051036 regulation of endosome size; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051057 positive regulation of small GTPase mediated signal transduction; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061564 axon development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0098916 anterograde trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901360 organic cyclic compound metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0014069 postsynaptic density; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030424 axon; GO:0030425 dendrite; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0044309 neuron spine; GO:0045202 synapse; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005096 GTPase activator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0019207 kinase regulator activity; GO:0019209 kinase activator activity; GO:0019887 protein kinase regulator activity; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0030295 protein kinase activator activity; GO:0030695 GTPase regulator activity; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043539 protein serine/threonine kinase activator activity; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0098772 molecular function regulator;","PF00621","PF00621 RhoGEF domain","S","KOG1426","FOG: RCC1 domain","WP2447 AMYOTROPHIC LATERAL SCLEROSIS ALS;WP4754 IL18 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2447_r113794;http://www.wikipathways.org/instance/WP4754_r115147",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs;R-HSA-9007101 Rab regulation of trafficking;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8876198;https://reactome.org/PathwayBrowser/#/R-HSA-9007101;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9716542","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q96RF0","Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2","SNX18",1.100341843,0.549468492,"nochange",5170.55,6247.81,4194.07,5292.4,5002.69,6883.92,0.946079221,1.143190418,0.767408202,0.968374673,0.915365107,1.259582379,"nucleus","K17923","SNX9_18_33; sorting nexin-9/18/33","hsa05132 Salmonella infection","GO:0000045 autophagosome assembly; GO:0000278 mitotic cell cycle; GO:0000281 mitotic cytokinesis; GO:0000910 cytokinesis; GO:0001505 regulation of neurotransmitter levels; GO:0001666 response to hypoxia; GO:0001845 phagolysosome assembly; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0001956 positive regulation of neurotransmitter secretion; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006906 vesicle fusion; GO:0006907 pinocytosis; GO:0006909 phagocytosis; GO:0006914 autophagy; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007009 plasma membrane organization; GO:0007032 endosome organization; GO:0007033 vacuole organization; GO:0007040 lysosome organization; GO:0007049 cell cycle; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009056 catabolic process; GO:0009628 response to abiotic stimulus; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010324 membrane invagination; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0012501 programmed cell death; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0017038 protein import; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030032 lamellipodium assembly; GO:0030100 regulation of endocytosis; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032459 regulation of protein oligomerization; GO:0032461 positive regulation of protein oligomerization; GO:0032506 cytokinetic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0034613 cellular protein localization; GO:0036089 cleavage furrow formation; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043254 regulation of protein-containing complex assembly; GO:0043277 apoptotic cell clearance; GO:0043547 positive regulation of GTPase activity; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044351 macropinocytosis; GO:0045184 establishment of protein localization; GO:0045732 positive regulation of protein catabolic process; GO:0045806 negative regulation of endocytosis; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045862 positive regulation of proteolysis; GO:0045937 positive regulation of phosphate metabolic process; GO:0046907 intracellular transport; GO:0046928 regulation of neurotransmitter secretion; GO:0048284 organelle fusion; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050806 positive regulation of synaptic transmission; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051043 regulation of membrane protein ectodomain proteolysis; GO:0051044 positive regulation of membrane protein ectodomain proteolysis; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051301 cell division; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051347 positive regulation of transferase activity; GO:0051588 regulation of neurotransmitter transport; GO:0051590 positive regulation of neurotransmitter transport; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0060988 lipid tube assembly; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0061919 process utilizing autophagic mechanism; GO:0065003 protein-containing complex assembly; GO:0065005 protein-lipid complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070482 response to oxygen levels; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071825 protein-lipid complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080171 lytic vacuole organization; GO:0090174 organelle membrane fusion; GO:0090382 phagosome maturation; GO:0090385 phagosome-lysosome fusion; GO:0090386 phagosome maturation involved in apoptotic cell clearance; GO:0090387 phagolysosome assembly involved in apoptotic cell clearance; GO:0090389 phagosome-lysosome fusion involved in apoptotic cell clearance; GO:0097194 execution phase of apoptosis; GO:0097320 plasma membrane tubulation; GO:0097581 lamellipodium organization; GO:0098657 import into cell; GO:0099024 plasma membrane invagination; GO:0099177 regulation of trans-synaptic signaling; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1903047 mitotic cell cycle process; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903828 negative regulation of protein localization; GO:1903829 positive regulation of protein localization; GO:1905037 autophagosome organization; GO:1990709 presynaptic active zone organization; GO:2000008 regulation of protein localization to cell surface; GO:2000009 negative regulation of protein localization to cell surface; GO:2000010 positive regulation of protein localization to cell surface;","GO:0001726 ruffle; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0009898 cytoplasmic side of plasma membrane; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0030424 axon; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0030659 cytoplasmic vesicle membrane; GO:0031090 organelle membrane; GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032009 early phagosome; GO:0036477 somatodendritic compartment; GO:0042734 presynaptic membrane; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0045335 phagocytic vesicle; GO:0048471 perinuclear region of cytoplasm; GO:0061174 type I terminal bouton; GO:0070062 extracellular exosome; GO:0071212 subsynaptic reticulum; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0097708 intracellular vesicle; GO:0098552 side of membrane; GO:0098562 cytoplasmic side of membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1903561 extracellular vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005545 1-phosphatidylinositol binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0005547 phosphatidylinositol-3",4,"5-trisphosphate binding; GO:0008289 lipid binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0031625 ubiquitin protein ligase binding; GO:0035091 phosphatidylinositol binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043621 protein self-association; GO:0044389 ubiquitin-like protein ligase binding; GO:0044877 protein-containing complex binding; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding; GO:0071933 Arp2/3 complex binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF14604; PF00787; PF10456","PF14604 Variant SH3 domain; PF00787 PX domain; PF10456 WASP-binding domain of Sorting nexin protein","U","KOG2528","Sorting nexin SNX9/SH3PX1 and related proteins",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8856828 Clathrin-mediated endocytosis","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8856828"]
["Q96RP9","Elongation factor G"," mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2","GFM1",1.206161342,0.000345899,"up",58949,60486,60068.1,72053.2,74056.3,70400.2,0.893137798,0.916424924,0.91009331,1.091679865,1.122028884,1.06663522,"mitochondria","K02355",null,null,"GO:0006412 translation; GO:0006414 translational elongation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0019538 protein metabolic process; GO:0032543 mitochondrial translation; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0071704 organic substance metabolic process; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003746 translation elongation factor activity; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0008135 translation factor activity"," RNA binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017111 nucleoside-triphosphatase activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00009; PF03144; PF14492; PF03764; PF00679","PF00009 Elongation factor Tu GTP binding domain; PF03144 Elongation factor Tu domain 2; PF14492 Elongation Factor G"," domain III; PF03764 Elongation factor G"," domain IV; PF00679 Elongation factor G C-terminus","J","KOG0465","Mitochondrial elongation factor",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q96S52","GPI transamidase component PIG-S OS=Homo sapiens OX=9606 GN=PIGS PE=1 SV=3","PIGS",0.677270328,0.004867096,"down",14273.4,15840.5,14405,10908.1,10346.4,8896.83,1.146914908,1.272836578,1.157489404,0.876501921,0.831367467,0.714889722,"endoplasmic reticulum","K05291","PIGS; GPI-anchor transamidase subunit S","hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; hsa01100 Metabolic pathways","GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0006464 cellular protein modification process; GO:0006497 protein lipidation; GO:0006505 GPI anchor metabolic process; GO:0006506 GPI anchor biosynthetic process; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006664 glycolipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009247 glycolipid biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016255 attachment of GPI anchor to protein; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0042051 compound eye photoreceptor development; GO:0042052 rhabdomere development; GO:0042157 lipoprotein metabolic process; GO:0042158 lipoprotein biosynthetic process; GO:0042461 photoreceptor cell development; GO:0042462 eye photoreceptor cell development; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044085 cellular component biogenesis; GO:0044091 membrane biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045313 rhabdomere membrane biogenesis; GO:0046467 membrane lipid biosynthetic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046530 photoreceptor cell differentiation; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048592 eye morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090407 organophosphate biosynthetic process; GO:0090596 sensory organ morphogenesis; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903509 liposaccharide metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042765 GPI-anchor transamidase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex;",{"$nulls":3},"MO","KOG2459","GPI transamidase complex"," GPI17/PIG-S component"," involved in glycosylphosphatidylinositol anchor biosynthesis",{"$nulls":3},"R-HSA-162791 Attachment of GPI anchor to uPAR;R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-162791;https://reactome.org/PathwayBrowser/#/R-HSA-163125;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q96S97","Myeloid-associated differentiation marker OS=Homo sapiens OX=9606 GN=MYADM PE=1 SV=2","MYADM",1.09981731,0.108964349,"nochange",92102.2,86954.7,79139.8,97748.7,92972.4,93248.1,1.019269563,0.962303605,0.875818269,1.081757816,1.028899826,1.031950921,"plasma membrane",{"$nulls":3},"GO:0001885 endothelial cell development; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0003158 endothelium development; GO:0007162 negative regulation of cell adhesion; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008104 protein localization; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010470 regulation of gastrulation; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010810 regulation of cell-substrate adhesion; GO:0010811 positive regulation of cell-substrate adhesion; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022407 regulation of cell-cell adhesion; GO:0022408 negative regulation of cell-cell adhesion; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030837 negative regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031579 membrane raft organization; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032272 negative regulation of protein polymerization; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0034114 regulation of heterotypic cell-cell adhesion; GO:0034115 negative regulation of heterotypic cell-cell adhesion; GO:0034613 cellular protein localization; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0045446 endothelial cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045785 positive regulation of cell adhesion; GO:0045936 negative regulation of phosphate metabolic process; GO:0045995 regulation of embryonic development; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051641 cellular localization; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0061024 membrane organization; GO:0061028 establishment of endothelial barrier; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070587 regulation of cell-cell adhesion involved in gastrulation; GO:0070727 cellular macromolecule localization; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0072659 protein localization to plasma membrane; GO:0080090 regulation of primary metabolic process; GO:0090036 regulation of protein kinase C signaling; GO:0090038 negative regulation of protein kinase C signaling; GO:0090066 regulation of anatomical structure size; GO:0110053 regulation of actin filament organization; GO:1900024 regulation of substrate adhesion-dependent cell spreading; GO:1900026 positive regulation of substrate adhesion-dependent cell spreading; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1990778 protein localization to cell periphery; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030054 cell junction; GO:0030863 cortical cytoskeleton; GO:0030864 cortical actin cytoskeleton; GO:0031252 cell leading edge; GO:0042995 cell projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0045121 membrane raft; GO:0071944 cell periphery; GO:0098857 membrane microdomain; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;",null,"PF01284","PF01284 Membrane-associating domain","V","KOG4788","Members of chemokine-like factor super family and related proteins"]
["Q96T60","Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1","PNKP",0.892394264,0.044484305,"nochange",36908.6,33783.7,35969.3,31695.8,33359.7,30128.7,1.097132564,1.004242843,1.069211249,0.942178633,0.991639162,0.895595549,"nucleus","K08073",null,null,"GO:0000718 nucleotide-excision repair"," DNA damage removal; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006281 DNA repair; GO:0006289 nucleotide-excision repair; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006979 response to oxidative stress; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010835 regulation of protein ADP-ribosylation; GO:0010836 negative regulation of protein ADP-ribosylation; GO:0016310 phosphorylation; GO:0016311 dephosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032204 regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032212 positive regulation of telomere maintenance via telomerase; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044349 DNA excision; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046939 nucleotide phosphorylation; GO:0046940 nucleoside monophosphate phosphorylation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051606 detection of stimulus; GO:0051716 cellular response to stimulus; GO:0051972 regulation of telomerase activity; GO:0051973 positive regulation of telomerase activity; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090407 organophosphate biosynthetic process; GO:0098501 polynucleotide dephosphorylation; GO:0098502 DNA dephosphorylation; GO:0098506 polynucleotide 3' dephosphorylation; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1904353 regulation of telomere capping; GO:1904355 positive regulation of telomere capping; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904358 positive regulation of telomere maintenance via telomere lengthening; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000573 positive regulation of DNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003684 damaged DNA binding; GO:0003690 double-stranded DNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0016776 phosphotransferase activity"," phosphate group as acceptor; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0017076 purine nucleotide binding; GO:0019205 nucleobase-containing compound kinase activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042578 phosphoric ester hydrolase activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046403 polynucleotide 3'-phosphatase activity; GO:0046404 polydeoxyribonucleotide 5'-hydroxyl-kinase activity; GO:0050145 nucleoside monophosphate kinase activity; GO:0051731 polynucleotide 5'-hydroxyl-kinase activity; GO:0051733 polydeoxyribonucleotide kinase activity; GO:0051734 polynucleotide kinase activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0098518 polynucleotide phosphatase activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF17913; PF13671","PF17913 FHA domain; PF13671 AAA domain","L","KOG2134","Polynucleotide kinase 3' phosphatase","WP4752 BASE EXCISION REPAIR;WP4946 DNA REPAIR PATHWAYS FULL NETWORK","http://www.wikipathways.org/instance/WP4752_r119239;http://www.wikipathways.org/instance/WP4946_r117703",null,"R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway;R-HSA-73884 Base Excision Repair;R-HSA-73894 DNA Repair;R-HSA-73933 Resolution of Abasic Sites (AP sites)","https://reactome.org/PathwayBrowser/#/R-HSA-5649702;https://reactome.org/PathwayBrowser/#/R-HSA-73884;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-73933"]
["Q99426","Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2","TBCB",1.122961208,0.020488177,"nochange",27512.9,27822.7,30193,31345.9,32124.8,32574.6,0.909147185,0.919384339,0.997709473,1.035806358,1.061544638,1.076408008,"extracellular","K17262",null,null,"GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0003006 developmental process involved in reproduction; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007163 establishment or maintenance of cell polarity; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007389 pattern specification process; GO:0009798 axis specification; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0016043 cellular component organization; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030010 establishment of cell polarity; GO:0030154 cell differentiation; GO:0031122 cytoplasmic microtubule organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035089 establishment of apical/basal cell polarity; GO:0044703 multi-organism reproductive process; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0061162 establishment of monopolar cell polarity; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061339 establishment or maintenance of monopolar cell polarity; GO:0071840 cellular component organization or biogenesis; GO:0097435 supramolecular fiber organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005938 cell cortex; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0072686 mitotic spindle; GO:0099568 cytoplasmic region;",null,"PF14560; PF01302","PF14560 Ubiquitin-like domain; PF01302 CAP-Gly domain","O","KOG3206","Alpha-tubulin folding cofactor B",{"$nulls":3},"R-HSA-389977 Post-chaperonin tubulin folding pathway;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins","https://reactome.org/PathwayBrowser/#/R-HSA-389977;https://reactome.org/PathwayBrowser/#/R-HSA-391251;https://reactome.org/PathwayBrowser/#/R-HSA-392499"]
["Q99541","Perilipin-2 OS=Homo sapiens OX=9606 GN=PLIN2 PE=1 SV=2","PLIN2",1.703074514,2.09645E-4,"up",6169.94,6536.33,6513.03,10571.3,10437,11723.6,0.712584887,0.754900368,0.752209381,1.220911163,1.205400453,1.353993748,"mitochondria","K17284","PLIN2; perilipin-2","hsa03320 PPAR signaling pathway","GO:0006629 lipid metabolic process; GO:0006638 neutral lipid metabolic process; GO:0006639 acylglycerol metabolic process; GO:0006641 triglyceride metabolic process; GO:0006642 triglyceride mobilization; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006869 lipid transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0010883 regulation of lipid storage; GO:0010884 positive regulation of lipid storage; GO:0010889 regulation of sequestering of triglyceride; GO:0010890 positive regulation of sequestering of triglyceride; GO:0010896 regulation of triglyceride catabolic process; GO:0010898 positive regulation of triglyceride catabolic process; GO:0010970 transport along microtubule; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015849 organic acid transport; GO:0015908 fatty acid transport; GO:0015909 long-chain fatty acid transport; GO:0016043 cellular component organization; GO:0019216 regulation of lipid metabolic process; GO:0019222 regulation of metabolic process; GO:0019915 lipid storage; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0030730 sequestering of triglyceride; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031887 lipid droplet transport along microtubule; GO:0032879 regulation of localization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034389 lipid droplet organization; GO:0034613 cellular protein localization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0045833 negative regulation of lipid metabolic process; GO:0045834 positive regulation of lipid metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046907 intracellular transport; GO:0046942 carboxylic acid transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050994 regulation of lipid catabolic process; GO:0050995 negative regulation of lipid catabolic process; GO:0050996 positive regulation of lipid catabolic process; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051235 maintenance of location; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072384 organelle transport along microtubule; GO:0080090 regulation of primary metabolic process; GO:0090207 regulation of triglyceride metabolic process; GO:0090208 positive regulation of triglyceride metabolic process; GO:0099111 microtubule-based transport; GO:1905952 regulation of lipid localization; GO:1905954 positive regulation of lipid localization; GO:1990044 protein localization to lipid droplet;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005811 lipid droplet; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0032991 protein-containing complex; GO:0032994 protein-lipid complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery;","GO:0005488 binding; GO:0005515 protein binding;",{"$nulls":5},"WP236 ADIPOGENESIS","http://www.wikipathways.org/instance/WP236_r105873",null,"R-HSA-1430728 Metabolism;R-HSA-1632852 Macroautophagy;R-HSA-1989781 PPARA activates gene expression;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-556833 Metabolism of lipids;R-HSA-9612973 Autophagy;R-HSA-9613354 Lipophagy;R-HSA-9613829 Chaperone Mediated Autophagy;R-HSA-9615710 Late endosomal microautophagy;R-HSA-9663891 Selective autophagy","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1632852;https://reactome.org/PathwayBrowser/#/R-HSA-1989781;https://reactome.org/PathwayBrowser/#/R-HSA-400206;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9613354;https://reactome.org/PathwayBrowser/#/R-HSA-9613829;https://reactome.org/PathwayBrowser/#/R-HSA-9615710;https://reactome.org/PathwayBrowser/#/R-HSA-9663891","ADIPOGENESIS;HYPOXIA;IL2 STAT5 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING"]
["Q99653","Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3","CHP1",1.276138845,0.102022705,"nochange",13511.4,18905.9,19286.4,20480,22510.2,22990.9,0.688860414,0.963891684,0.98329096,1.044145038,1.147652033,1.172159871,"cytoplasm","K17610",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0001578 microtubule bundle formation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002028 regulation of sodium ion transport; GO:0006022 aminoglycan metabolic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006082 organic acid metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006469 negative regulation of protein kinase activity; GO:0006611 protein export from nucleus; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006813 potassium ion transport; GO:0006873 cellular ion homeostasis; GO:0006885 regulation of pH; GO:0006886 intracellular protein transport; GO:0006887 exocytosis; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009268 response to pH; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010155 regulation of proton transport; GO:0010447 response to acidic pH; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010560 positive regulation of glycoprotein biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010765 positive regulation of sodium ion transport; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0010959 regulation of metal ion transport; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016054 organic acid catabolic process; GO:0016192 vesicle-mediated transport; GO:0017156 calcium-ion regulated exocytosis; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019722 calcium-mediated signaling; GO:0019725 cellular homeostasis; GO:0019752 carboxylic acid metabolic process; GO:0019932 second-messenger-mediated signaling; GO:0022406 membrane docking; GO:0022607 cellular component assembly; GO:0022898 regulation of transmembrane transporter activity; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030203 glycosaminoglycan metabolic process; GO:0030212 hyaluronan metabolic process; GO:0030214 hyaluronan catabolic process; GO:0030641 regulation of cellular pH; GO:0031122 cytoplasmic microtubule organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0031952 regulation of protein autophosphorylation; GO:0031953 negative regulation of protein autophosphorylation; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032415 regulation of sodium:proton antiporter activity; GO:0032417 positive regulation of sodium:proton antiporter activity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033673 negative regulation of kinase activity; GO:0034613 cellular protein localization; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0035303 regulation of dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035556 intracellular signal transduction; GO:0042306 regulation of protein import into nucleus; GO:0042308 negative regulation of protein import into nucleus; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043436 oxoacid metabolic process; GO:0043549 regulation of kinase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0045055 regulated exocytosis; GO:0045056 transcytosis; GO:0045184 establishment of protein localization; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046395 carboxylic acid catabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046823 negative regulation of nucleocytoplasmic transport; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050821 protein stabilization; GO:0050848 regulation of calcium-mediated signaling; GO:0050849 negative regulation of calcium-mediated signaling; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051259 protein complex oligomerization; GO:0051336 regulation of hydrolase activity; GO:0051338 regulation of transferase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051348 negative regulation of transferase activity; GO:0051453 regulation of intracellular pH; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055067 monovalent inorganic cation homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0060049 regulation of protein glycosylation; GO:0060050 positive regulation of protein glycosylation; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070884 regulation of calcineurin-NFAT signaling cascade; GO:0070885 negative regulation of calcineurin-NFAT signaling cascade; GO:0071214 cellular response to abiotic stimulus; GO:0071467 cellular response to pH; GO:0071468 cellular response to acidic pH; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090313 regulation of protein targeting to membrane; GO:0090314 positive regulation of protein targeting to membrane; GO:0090316 positive regulation of intracellular protein transport; GO:0090317 negative regulation of intracellular protein transport; GO:0097435 supramolecular fiber organization; GO:0098771 inorganic ion homeostasis; GO:0104004 cellular response to environmental stimulus; GO:0106056 regulation of calcineurin-mediated signaling; GO:0106057 negative regulation of calcineurin-mediated signaling; GO:1900180 regulation of protein localization to nucleus; GO:1900181 negative regulation of protein localization to nucleus; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901214 regulation of neuron death; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902305 regulation of sodium ion transmembrane transport; GO:1902307 positive regulation of sodium ion transmembrane transport; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903018 regulation of glycoprotein metabolic process; GO:1903020 positive regulation of glycoprotein metabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903510 mucopolysaccharide metabolic process; GO:1903533 regulation of protein targeting; GO:1903828 negative regulation of protein localization; GO:1903829 positive regulation of protein localization; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1904589 regulation of protein import; GO:1904590 negative regulation of protein import; GO:1904950 negative regulation of establishment of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905475 regulation of protein localization to membrane; GO:1905477 positive regulation of protein localization to membrane; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000649 regulation of sodium ion transmembrane transporter activity; GO:2000651 positive regulation of sodium ion transmembrane transporter activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0005215 transporter activity; GO:0005488 binding; GO:0005509 calcium ion binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015459 potassium channel regulator activity; GO:0015631 tubulin binding; GO:0016247 channel regulator activity; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0048306 calcium-dependent protein binding; GO:0098772 molecular function regulator; GO:0099106 ion channel regulator activity;","PF13499","PF13499 EF-hand domain pair","T","KOG0034","Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B)"," EF-Hand superfamily protein","WP3863 TCELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION","http://www.wikipathways.org/instance/WP3863_r120420",null,"R-HSA-1430728 Metabolism;R-HSA-1630316 Glycosaminoglycan metabolism;R-HSA-2142845 Hyaluronan metabolism;R-HSA-2160916 Hyaluronan uptake and degradation;R-HSA-71387 Metabolism of carbohydrates","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1630316;https://reactome.org/PathwayBrowser/#/R-HSA-2142845;https://reactome.org/PathwayBrowser/#/R-HSA-2160916;https://reactome.org/PathwayBrowser/#/R-HSA-71387"]
["Q99685","Monoglyceride lipase OS=Homo sapiens OX=9606 GN=MGLL PE=1 SV=2","MGLL",1.268783992,0.093458747,"nochange",2224.97,2691.61,2811.41,3017.49,2974.76,3812.9,0.761404974,0.921093427,0.962090076,1.032612527,1.017989932,1.304809064,"cytoplasm","K01054","MGLL; acylglycerol lipase [EC:3.1.1.23]","hsa04923 Regulation of lipolysis in adipocytes; hsa04723 Retrograde endocannabinoid signaling; hsa04714 Thermogenesis; hsa00561 Glycerolipid metabolism; hsa01100 Metabolic pathways","GO:0001558 regulation of cell growth; GO:0001676 long-chain fatty acid metabolic process; GO:0003008 system process; GO:0003013 circulatory system process; GO:0003018 vascular process in circulatory system; GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006638 neutral lipid metabolic process; GO:0006639 acylglycerol metabolic process; GO:0006690 icosanoid metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008015 blood circulation; GO:0008152 metabolic process; GO:0008277 regulation of G protein-coupled receptor signaling pathway; GO:0008361 regulation of cell size; GO:0009056 catabolic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0016042 lipid catabolic process; GO:0016043 cellular component organization; GO:0019369 arachidonic acid metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030516 regulation of axon extension; GO:0031344 regulation of cell projection organization; GO:0031347 regulation of defense response; GO:0031644 regulation of nervous system process; GO:0032101 regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032787 monocarboxylic acid metabolic process; GO:0033559 unsaturated fatty acid metabolic process; GO:0035150 regulation of tube size; GO:0035296 regulation of tube diameter; GO:0036155 acylglycerol acyl-chain remodeling; GO:0040008 regulation of growth; GO:0043436 oxoacid metabolic process; GO:0044057 regulation of system process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0046461 neutral lipid catabolic process; GO:0046464 acylglycerol catabolic process; GO:0046486 glycerolipid metabolic process; GO:0046503 glycerolipid catabolic process; GO:0048167 regulation of synaptic plasticity; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048638 regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050727 regulation of inflammatory response; GO:0050767 regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0050805 negative regulation of synaptic transmission; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051239 regulation of multicellular organismal process; GO:0051930 regulation of sensory perception of pain; GO:0051931 regulation of sensory perception; GO:0051960 regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060292 long-term synaptic depression; GO:0061387 regulation of extent of cell growth; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080134 regulation of response to stress; GO:0090066 regulation of anatomical structure size; GO:0097746 blood vessel diameter maintenance; GO:0099177 regulation of trans-synaptic signaling; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901568 fatty acid derivative metabolic process; GO:1901575 organic substance catabolic process; GO:2000026 regulation of multicellular organismal development; GO:2000124 regulation of endocannabinoid signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005811 lipid droplet; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030424 axon; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043196 varicosity; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044304 main axon; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0098827 endoplasmic reticulum subcompartment; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0004620 phospholipase activity; GO:0004622 lysophospholipase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016298 lipase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0047372 acylglycerol lipase activity; GO:0052689 carboxylic ester hydrolase activity;",null,null,"I","KOG1455","Lysophospholipase","WP5102 FAMILIAL PARTIAL LIPODYSTROPHY FPLD;WP4321 THERMOGENESIS;WP4746 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS","http://www.wikipathways.org/instance/WP5102_r119174;http://www.wikipathways.org/instance/WP4321_r106178;http://www.wikipathways.org/instance/WP4746_r120402",null,"R-HSA-109582 Hemostasis;R-HSA-114508 Effects of PIP2 hydrolysis;R-HSA-1430728 Metabolism;R-HSA-1482883 Acyl chain remodeling of DAG and TAG;R-HSA-1483206 Glycerophospholipid biosynthesis;R-HSA-1483257 Phospholipid metabolism;R-HSA-162582 Signal Transduction;R-HSA-163560 Triglyceride catabolism;R-HSA-372790 Signaling by GPCR;R-HSA-388396 GPCR downstream signalling;R-HSA-416476 G alpha (q) signalling events;R-HSA-426048 Arachidonate production from DAG;R-HSA-556833 Metabolism of lipids;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-8979227 Triglyceride metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114508;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1482883;https://reactome.org/PathwayBrowser/#/R-HSA-1483206;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-163560;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-388396;https://reactome.org/PathwayBrowser/#/R-HSA-416476;https://reactome.org/PathwayBrowser/#/R-HSA-426048;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-8979227","ADIPOGENESIS;FATTY ACID METABOLISM;UV RESPONSE DN","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_DN"]
["Q99816","Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2","TSG101",1.104539193,0.095857272,"nochange",35888.8,31136.6,33655.5,38345.2,37255.7,35605.1,1.016262921,0.881694904,0.953022579,1.085820785,1.05496942,1.00822939,"cytoplasm","K12183","TSG101; ESCRT-I complex subunit TSG101","hsa03250 Viral life cycle - HIV-1; hsa04144 Endocytosis","GO:0001558 regulation of cell growth; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006469 negative regulation of protein kinase activity; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006513 protein monoubiquitination; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006858 extracellular transport; GO:0006887 exocytosis; GO:0006914 autophagy; GO:0006996 organelle organization; GO:0007032 endosome organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007049 cell cycle; GO:0007163 establishment or maintenance of cell polarity; GO:0007175 negative regulation of epidermal growth factor-activated receptor activity; GO:0007176 regulation of epidermal growth factor-activated receptor activity; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0008333 endosome to lysosome transport; GO:0008544 epidermis development; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009913 epidermal cell differentiation; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0016322 neuron remodeling; GO:0016567 protein ubiquitination; GO:0017157 regulation of exocytosis; GO:0019058 viral life cycle; GO:0019068 virion assembly; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030011 maintenance of cell polarity; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030163 protein catabolic process; GO:0030182 neuron differentiation; GO:0030216 keratinocyte differentiation; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032509 endosome transport via multivesicular body sorting pathway; GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway; GO:0032801 receptor catabolic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0032984 protein-containing complex disassembly; GO:0033043 regulation of organelle organization; GO:0033673 negative regulation of kinase activity; GO:0035088 establishment or maintenance of apical/basal cell polarity; GO:0035090 maintenance of apical/basal cell polarity; GO:0036211 protein modification process; GO:0036257 multivesicular body organization; GO:0036258 multivesicular body assembly; GO:0039702 viral budding via host ESCRT complex; GO:0040008 regulation of growth; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042058 regulation of epidermal growth factor receptor signaling pathway; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042551 neuron maturation; GO:0043086 negative regulation of catalytic activity; GO:0043112 receptor metabolic process; GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; GO:0043170 macromolecule metabolic process; GO:0043405 regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043588 skin development; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045570 regulation of imaginal disc growth; GO:0045571 negative regulation of imaginal disc growth; GO:0045786 negative regulation of cell cycle; GO:0045807 positive regulation of endocytosis; GO:0045859 regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045921 positive regulation of exocytosis; GO:0045926 negative regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046620 regulation of organ growth; GO:0046621 negative regulation of organ growth; GO:0046755 viral budding; GO:0046903 secretion; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060627 regulation of vesicle-mediated transport; GO:0061097 regulation of protein tyrosine kinase activity; GO:0061099 negative regulation of protein tyrosine kinase activity; GO:0061245 establishment or maintenance of bipolar cell polarity; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070647 protein modification by small protein conjugation or removal; GO:0070925 organelle assembly; GO:0071695 anatomical structure maturation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071985 multivesicular body sorting pathway; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0097352 autophagosome maturation; GO:0097734 extracellular exosome biogenesis; GO:0140112 extracellular vesicle biogenesis; GO:1901184 regulation of ERBB signaling pathway; GO:1901185 negative regulation of ERBB signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902115 regulation of organelle assembly; GO:1902531 regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1903541 regulation of exosomal secretion; GO:1903543 positive regulation of exosomal secretion; GO:1903551 regulation of extracellular exosome assembly; GO:1903772 regulation of viral budding via host ESCRT complex; GO:1903774 positive regulation of viral budding via host ESCRT complex; GO:1903829 positive regulation of protein localization; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:1904951 positive regulation of establishment of protein localization; GO:1990182 exosomal secretion; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000272 negative regulation of signaling receptor activity; GO:2000395 regulation of ubiquitin-dependent endocytosis; GO:2000397 positive regulation of ubiquitin-dependent endocytosis; GO:2001141 regulation of RNA biosynthetic process;","GO:0000813 ESCRT I complex; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005771 multivesicular body; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036452 ESCRT complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070062 extracellular exosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:1903561 extracellular vesicle;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0030374 nuclear receptor coactivator activity; GO:0031625 ubiquitin protein ligase binding; GO:0032182 ubiquitin-like protein binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043130 ubiquitin binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044877 protein-containing complex binding; GO:0046790 virion binding; GO:0046983 protein dimerization activity; GO:0048306 calcium-dependent protein binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF05743; PF09454","PF05743 UEV domain; PF09454 Vps23 core domain","OU","KOG2391","Vacuolar sorting protein/ubiquitin receptor VPS23","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME;WP4217 EBOLA VIRUS INFECTION IN HOST","http://www.wikipathways.org/instance/WP4932_r118797;http://www.wikipathways.org/instance/WP4217_r120623","Transcription factor","R-HSA-162587 HIV Life Cycle;R-HSA-162588 Budding and maturation of HIV virion;R-HSA-162599 Late Phase of HIV Life Cycle;R-HSA-162906 HIV Infection;R-HSA-1643685 Disease;R-HSA-174490 Membrane binding and targetting of GAG proteins;R-HSA-174495 Synthesis And Processing Of GAG"," GAGPOL Polyproteins;R-HSA-175474 Assembly Of The HIV Virion;R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5663205 Infectious disease;R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT);R-HSA-9609646 HCMV Infection;R-HSA-9610379 HCMV Late Events;R-HSA-9612973 Autophagy;R-HSA-9615710 Late endosomal microautophagy","https://reactome.org/PathwayBrowser/#/R-HSA-162587;https://reactome.org/PathwayBrowser/#/R-HSA-162588;https://reactome.org/PathwayBrowser/#/R-HSA-162599;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-174490;https://reactome.org/PathwayBrowser/#/R-HSA-174495;https://reactome.org/PathwayBrowser/#/R-HSA-175474;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-917729;https://reactome.org/PathwayBrowser/#/R-HSA-9609646;https://reactome.org/PathwayBrowser/#/R-HSA-9610379;https://reactome.org/PathwayBrowser/#/R-HSA-9612973;https://reactome.org/PathwayBrowser/#/R-HSA-9615710","DNA REPAIR;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["Q99836","Myeloid differentiation primary response protein MyD88 OS=Homo sapiens OX=9606 GN=MYD88 PE=1 SV=1","MYD88",0.729207222,0.027252877,"nochange",9492.97,9220.72,7330.69,6305.97,5893.65,6792.13,1.264713909,1.22844303,0.976641199,0.840121476,0.78518958,0.904890807,"mitochondria","K04729","MYD88; myeloid differentiation primary response protein MyD88","hsa05161 Hepatitis B; hsa05170 Human immunodeficiency virus 1 infection; hsa05169 Epstein-Barr virus infection; hsa05131 Shigellosis; hsa05132 Salmonella infection; hsa04621 NOD-like receptor signaling pathway; hsa05168 Herpes simplex virus 1 infection; hsa05145 Toxoplasmosis; hsa05144 Malaria; hsa05135 Yersinia infection; hsa04010 MAPK signaling pathway; hsa05171 Coronavirus disease - COVID-19; hsa04936 Alcoholic liver disease; hsa05134 Legionellosis; hsa05152 Tuberculosis; hsa05162 Measles; hsa05140 Leishmaniasis; hsa05142 Chagas disease; hsa05164 Influenza A; hsa05143 African trypanosomiasis; hsa05133 Pertussis; hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer; hsa04620 Toll-like receptor signaling pathway; hsa05130 Pathogenic Escherichia coli infection; hsa04064 NF-kappa B signaling pathway; hsa05417 Lipid and atherosclerosis","GO:0000165 MAPK cascade; GO:0001775 cell activation; GO:0001816 cytokine production; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0001885 endothelial cell development; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002218 activation of innate immune response; GO:0002221 pattern recognition receptor signaling pathway; GO:0002224 toll-like receptor signaling pathway; GO:0002225 positive regulation of antimicrobial peptide production; GO:0002237 response to molecule of bacterial origin; GO:0002238 response to molecule of fungal origin; GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002253 activation of immune response; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002440 production of molecular mediator of immune response; GO:0002443 leukocyte mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002685 regulation of leukocyte migration; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002700 regulation of production of molecular mediator of immune response; GO:0002702 positive regulation of production of molecular mediator of immune response; GO:0002755 MyD88-dependent toll-like receptor signaling pathway; GO:0002757 immune response-activating signal transduction; GO:0002758 innate immune response-activating signal transduction; GO:0002759 regulation of antimicrobial humoral response; GO:0002760 positive regulation of antimicrobial humoral response; GO:0002764 immune response-regulating signaling pathway; GO:0002775 antimicrobial peptide production; GO:0002781 antifungal peptide production; GO:0002784 regulation of antimicrobial peptide production; GO:0002788 regulation of antifungal peptide production; GO:0002804 positive regulation of antifungal peptide production; GO:0002831 regulation of response to biotic stimulus; GO:0002833 positive regulation of response to biotic stimulus; GO:0002920 regulation of humoral immune response; GO:0002922 positive regulation of humoral immune response; GO:0003002 regionalization; GO:0003158 endothelium development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0006959 humoral immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0008063 Toll signaling pathway; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008284 positive regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009612 response to mechanical stimulus; GO:0009615 response to virus; GO:0009617 response to bacterium; GO:0009620 response to fungus; GO:0009628 response to abiotic stimulus; GO:0009682 induced systemic resistance; GO:0009719 response to endogenous stimulus; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009953 dorsal/ventral pattern formation; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0012501 programmed cell death; GO:0016064 immunoglobulin mediated immune response; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019724 B cell mediated immunity; GO:0019730 antimicrobial humoral response; GO:0019732 antifungal humoral response; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030334 regulation of cell migration; GO:0030593 neutrophil chemotaxis; GO:0030595 leukocyte chemotaxis; GO:0030855 epithelial cell differentiation; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031663 lipopolysaccharide-mediated signaling pathway; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032479 regulation of type I interferon production; GO:0032481 positive regulation of type I interferon production; GO:0032494 response to peptidoglycan; GO:0032496 response to lipopolysaccharide; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032606 type I interferon production; GO:0032642 regulation of chemokine production; GO:0032660 regulation of interleukin-17 production; GO:0032667 regulation of interleukin-23 production; GO:0032675 regulation of interleukin-6 production; GO:0032680 regulation of tumor necrosis factor production; GO:0032722 positive regulation of chemokine production; GO:0032740 positive regulation of interleukin-17 production; GO:0032747 positive regulation of interleukin-23 production; GO:0032755 positive regulation of interleukin-6 production; GO:0032760 positive regulation of tumor necrosis factor production; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032944 regulation of mononuclear cell proliferation; GO:0032946 positive regulation of mononuclear cell proliferation; GO:0033554 cellular response to stress; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0034162 toll-like receptor 9 signaling pathway; GO:0034340 response to type I interferon; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0040008 regulation of growth; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0042117 monocyte activation; GO:0042119 neutrophil activation; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0042742 defense response to bacterium; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0043489 RNA stabilization; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0045321 leukocyte activation; GO:0045446 endothelial cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0048255 mRNA stabilization; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050670 regulation of lymphocyte proliferation; GO:0050671 positive regulation of lymphocyte proliferation; GO:0050727 regulation of inflammatory response; GO:0050729 positive regulation of inflammatory response; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050830 defense response to Gram-positive bacterium; GO:0050832 defense response to fungus; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051094 positive regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051403 stress-activated MAPK cascade; GO:0051674 localization of cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0055094 response to lipoprotein particle; GO:0060255 regulation of macromolecule metabolic process; GO:0060326 cell chemotaxis; GO:0060337 type I interferon signaling pathway; GO:0060429 epithelium development; GO:0060548 negative regulation of cell death; GO:0061013 regulation of mRNA catabolic process; GO:0061028 establishment of endothelial barrier; GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070555 response to interleukin-1; GO:0070663 regulation of leukocyte proliferation; GO:0070665 positive regulation of leukocyte proliferation; GO:0070887 cellular response to chemical stimulus; GO:0070935 3'-UTR-mediated mRNA stabilization; GO:0071214 cellular response to abiotic stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071260 cellular response to mechanical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071357 cellular response to type I interferon; GO:0071396 cellular response to lipid; GO:0071402 cellular response to lipoprotein particle stimulus; GO:0071496 cellular response to external stimulus; GO:0071621 granulocyte chemotaxis; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090557 establishment of endothelial intestinal barrier; GO:0097529 myeloid leukocyte migration; GO:0097530 granulocyte migration; GO:0098542 defense response to other organism; GO:0104004 cellular response to environmental stimulus; GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus; GO:1900015 regulation of cytokine production involved in inflammatory response; GO:1900017 positive regulation of cytokine production involved in inflammatory response; GO:1900150 regulation of defense response to fungus; GO:1901222 regulation of NIK/NF-kappaB signaling; GO:1901224 positive regulation of NIK/NF-kappaB signaling; GO:1901532 regulation of hematopoietic progenitor cell differentiation; GO:1901534 positive regulation of hematopoietic progenitor cell differentiation; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902369 negative regulation of RNA catabolic process; GO:1902373 negative regulation of mRNA catabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902622 regulation of neutrophil migration; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903311 regulation of mRNA metabolic process; GO:1903312 negative regulation of mRNA metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903555 regulation of tumor necrosis factor superfamily cytokine production; GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production; GO:1903706 regulation of hemopoiesis; GO:1903708 positive regulation of hemopoiesis; GO:1990266 neutrophil migration; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production; GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0014069 postsynaptic density; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032279 asymmetric synapse; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098794 postsynapse; GO:0098984 neuron to neuron synapse; GO:0099572 postsynaptic specialization;","GO:0005102 signaling receptor binding; GO:0005121 Toll binding; GO:0005123 death receptor binding; GO:0005126 cytokine receptor binding; GO:0005149 interleukin-1 receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005543 phospholipid binding; GO:0005546 phosphatidylinositol-4","5-bisphosphate binding; GO:0008289 lipid binding; GO:0019904 protein domain specific binding; GO:0032813 tumor necrosis factor receptor superfamily binding; GO:0035091 phosphatidylinositol binding; GO:0035325 Toll-like receptor binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043621 protein self-association; GO:0070851 growth factor receptor binding; GO:0070976 TIR domain binding; GO:1901981 phosphatidylinositol phosphate binding; GO:1902936 phosphatidylinositol bisphosphate binding;","PF00531","PF00531 Death domain",{"$nulls":3},"WP2324 AGERAGE PATHWAY;WP1772 APOPTOSIS MODULATION AND SIGNALING;WP5055 BURN WOUND HEALING;WP4136 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY;WP4666 HEPATITIS B INFECTION;WP4880 HOSTPATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION;WP4754 IL18 SIGNALING PATHWAY;WP2865 IL1 AND MEGAKARYOCYTES IN OBESITY;WP195 IL1 SIGNALING PATHWAY;WP2637 INTERLEUKIN1 IL1 STRUCTURAL PATHWAY;WP4478 LTF DANGER SIGNAL RESPONSE PATHWAY;WP4630 MEASLES VIRUS INFECTION;WP4329 MIRNAS INVOLVEMENT IN THE IMMUNE RESPONSE IN SEPSIS;WP3877 MYD88 DISTINCT INPUTOUTPUT PATHWAY;WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY;WP4496 SIGNAL TRANSDUCTION THROUGH IL1R;WP5098 TCELL ACTIVATION SARSCOV2;WP3851 TLR4 SIGNALING AND TOLERANCE;WP75 TOLLLIKE RECEPTOR SIGNALING PATHWAY;WP3858 TOLLLIKE RECEPTOR SIGNALING RELATED TO MYD88;WP4868 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARSCOV2 INFECTION","http://www.wikipathways.org/instance/WP2324_r120674;http://www.wikipathways.org/instance/WP1772_r120736;http://www.wikipathways.org/instance/WP5055_r120278;http://www.wikipathways.org/instance/WP4136_r120387;http://www.wikipathways.org/instance/WP4666_r119241;http://www.wikipathways.org/instance/WP4880_r119113;http://www.wikipathways.org/instance/WP4754_r115147;http://www.wikipathways.org/instance/WP2865_r106600;http://www.wikipathways.org/instance/WP195_r120702;http://www.wikipathways.org/instance/WP2637_r117962;http://www.wikipathways.org/instance/WP4478_r103756;http://www.wikipathways.org/instance/WP4630_r120771;http://www.wikipathways.org/instance/WP4329_r101725;http://www.wikipathways.org/instance/WP3877_r117828;http://www.wikipathways.org/instance/WP5115_r120597;http://www.wikipathways.org/instance/WP4496_r102693;http://www.wikipathways.org/instance/WP5098_r119538;http://www.wikipathways.org/instance/WP3851_r117847;http://www.wikipathways.org/instance/WP75_r119233;http://www.wikipathways.org/instance/WP3858_r117850;http://www.wikipathways.org/instance/WP4868_r120021",null,"R-HSA-1236974 ER-Phagosome pathway;R-HSA-1236975 Antigen processing-Cross presentation;R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1280218 Adaptive Immune System;R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs;R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade;R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane;R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade;R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade;R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade;R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade;R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade;R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-168898 Toll-like Receptor Cascades;R-HSA-1810476 RIP-mediated NFkB activation via ZBP1;R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade;R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA ;R-HSA-193639 p75NTR signals via NF-kB;R-HSA-193704 p75 NTR receptor-mediated signalling;R-HSA-199418 Negative regulation of the PI3K/AKT network;R-HSA-209543 p75NTR recruits signalling complexes;R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production ;R-HSA-446652 Interleukin-1 family signaling;R-HSA-449147 Signaling by Interleukins;R-HSA-5260271 Diseases of Immune System;R-HSA-5602358 Diseases associated with the TLR signaling cascade;R-HSA-5602498 MyD88 deficiency (TLR2/4);R-HSA-5602680 MyD88 deficiency (TLR5);R-HSA-5603037 IRAK4 deficiency (TLR5);R-HSA-5603041 IRAK4 deficiency (TLR2/4);R-HSA-6811558 PI5P"," PP2A and IER3 Regulate PI3K/AKT Signaling;R-HSA-73887 Death Receptor Signalling;R-HSA-9006925 Intracellular signaling by second messengers;R-HSA-9020702 Interleukin-1 signaling;R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling;R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation;R-HSA-975155 MyD88 dependent cascade initiated on endosome;R-HSA-975871 MyD88 cascade initiated on plasma membrane;R-HSA-983169 Class I MHC mediated antigen processing & presentation",null,"IL6 JAK STAT3 SIGNALING;INTERFERON GAMMA RESPONSE;PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL6_JAK_STAT3_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["Q9BQ61","Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1","TRIR",1.051217975,0.615028758,"nochange",9345.46,12646.8,13326.2,11958.6,12854.4,12314.4,0.773995367,1.047413889,1.103682115,0.990416844,1.064607419,1.019884366,"nucleus","K01149",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006401 RNA catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008152 metabolic process; GO:0008340 determination of adult lifespan; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0016075 rRNA catabolic process; GO:0019439 aromatic compound catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0034660 ncRNA metabolic process; GO:0034661 ncRNA catabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048856 anatomical structure development; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090503 RNA phosphodiester bond hydrolysis"," exonucleolytic; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process;",null,"GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004527 exonuclease activity; GO:0008408 3'-5' exonuclease activity; GO:0008409 5'-3' exonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds;"]
["Q9BQE5","Apolipoprotein L2 OS=Homo sapiens OX=9606 GN=APOL2 PE=1 SV=2","APOL2",0.545161078,0.019966605,"nochange",3086.07,3391.72,3413.36,1290.93,1820.51,2280.83,1.211536423,1.3315292,1.34002468,0.506796254,0.714699982,0.895413461,"plasma membrane","K14480",null,null,"GO:0000003 reproduction; GO:0001906 cell killing; GO:0002376 immune system process; GO:0002526 acute inflammatory response; GO:0006066 alcohol metabolic process; GO:0006464 cellular protein modification process; GO:0006629 lipid metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006821 chloride transport; GO:0006869 lipid transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006950 response to stress; GO:0006952 defense response; GO:0006953 acute-phase response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0007275 multicellular organism development; GO:0007565 female pregnancy; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008203 cholesterol metabolic process; GO:0009987 cellular process; GO:0010876 lipid localization; GO:0015698 inorganic anion transport; GO:0016125 sterol metabolic process; GO:0016192 vesicle-mediated transport; GO:0019538 protein metabolic process; GO:0019835 cytolysis; GO:0022414 reproductive process; GO:0031640 killing of cells of another organism; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0034220 ion transmembrane transport; GO:0035821 modulation of process of another organism; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044281 small molecule metabolic process; GO:0044364 disruption of cells of another organism; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045087 innate immune response; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0060135 maternal process involved in female pregnancy; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0098656 anion transmembrane transport; GO:0098657 import into cell; GO:0098660 inorganic ion transmembrane transport; GO:0098661 inorganic anion transmembrane transport; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901615 organic hydroxy compound metabolic process; GO:1902476 chloride transmembrane transport; GO:1902652 secondary alcohol metabolic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031224 intrinsic component of membrane; GO:0031974 membrane-enclosed lumen; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0032994 protein-lipid complex; GO:0034358 plasma lipoprotein particle; GO:0034361 very-low-density lipoprotein particle; GO:0034364 high-density lipoprotein particle; GO:0034385 triglyceride-rich plasma lipoprotein particle; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098827 endoplasmic reticulum subcompartment; GO:1990777 lipoprotein particle;","GO:0005102 signaling receptor binding; GO:0005215 transporter activity; GO:0005216 ion channel activity; GO:0005253 anion channel activity; GO:0005254 chloride channel activity; GO:0005319 lipid transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008035 high-density lipoprotein particle binding; GO:0008289 lipid binding; GO:0008509 anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015108 chloride transmembrane transporter activity; GO:0015267 channel activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022803 passive transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0044877 protein-containing complex binding; GO:0071813 lipoprotein particle binding; GO:0071814 protein-lipid complex binding;"]
["Q9BRA0","N-alpha-acetyltransferase 38"," NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA38 PE=1 SV=1","NAA38",1.138932904,0.388056191,"nochange",3558.95,2110.92,3007.7,3133.94,3260.77,3488.46,1.150476759,0.682382276,0.972278045,1.013086763,1.054086206,1.127689952,"extracellular","K20824",null,null,"GO:0010941 regulation of cell death; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0031248 protein acetyltransferase complex; GO:0031414 N-terminal protein acetyltransferase complex; GO:0031417 NatC complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;",null,"PF01423","PF01423 LSM domain ","K","KOG3168","U1 snRNP component",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6811440;https://reactome.org/PathwayBrowser/#/R-HSA-6811442","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["Q9BRX8","Peroxiredoxin-like 2A OS=Homo sapiens OX=9606 GN=PRXL2A PE=1 SV=3","PRXL2A",1.123886433,0.105649632,"nochange",18626.7,15431.9,17319.1,19878.4,19094,18770.3,1.024191627,0.848525115,0.952293063,1.093016521,1.049886181,1.032087492,"extracellular",{"$nulls":3},"GO:0002682 regulation of immune system process; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0008152 metabolic process; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0042221 response to chemical; GO:0045595 regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045670 regulation of osteoclast differentiation; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051239 regulation of multicellular organismal process; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0097237 cellular response to toxic substance; GO:0098754 detoxification; GO:0098869 cellular oxidant detoxification; GO:1902105 regulation of leukocyte differentiation; GO:1903706 regulation of hemopoiesis; GO:1990748 cellular detoxification; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;","GO:0016209 antioxidant activity;","PF13911","PF13911 AhpC/TSA antioxidant enzyme","S","KOG4498","Uncharacterized conserved protein"]
["Q9BSF0","Small membrane A-kinase anchor protein OS=Homo sapiens OX=9606 GN=C2orf88 PE=1 SV=2","C2orf88",1.280187769,0.10024485,"nochange",4381.89,3959.49,5548.02,6705.27,5466.59,5609.18,0.830153923,0.750129774,1.051078545,1.270320842,1.035651541,1.062665375,"extracellular"]
["Q9BSW2","EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2","CRACR2A",0.624012303,0.006060682,"down",7740.67,7812.13,7414.76,4338.33,5660.87,4332.84,1.245161342,1.256656372,1.192735579,0.697862175,0.910605476,0.696979056,"nucleus","K17199",null,null,"GO:0001775 cell activation; GO:0002115 store-operated calcium entry; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0009987 cellular process; GO:0010959 regulation of metal ion transport; GO:0016192 vesicle-mediated transport; GO:0022898 regulation of transmembrane transporter activity; GO:0030001 metal ion transport; GO:0032237 activation of store-operated calcium channel activity; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032879 regulation of localization; GO:0032940 secretion by cell; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0044093 positive regulation of molecular function; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051924 regulation of calcium ion transport; GO:0051928 positive regulation of calcium ion transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:1901019 regulation of calcium ion transmembrane transporter activity; GO:1901021 positive regulation of calcium ion transmembrane transporter activity; GO:1901339 regulation of store-operated calcium channel activity; GO:1901341 positive regulation of store-operated calcium channel activity; GO:1903169 regulation of calcium ion transmembrane transport; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1904427 positive regulation of calcium ion transmembrane transport; GO:2001257 regulation of cation channel activity; GO:2001259 positive regulation of cation channel activity;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035580 specific granule lumen; GO:0042581 specific granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005509 calcium ion binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding;","PF13499; PF00071","PF13499 EF-hand domain pair; PF00071 Ras family","TU","KOG0078","GTP-binding protein SEC4"," small G protein superfamily"," and related Ras family GTP-binding proteins","WP2877 VITAMIN D RECEPTOR PATHWAY","http://www.wikipathways.org/instance/WP2877_r119905",null,"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["Q9BTE3","Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2","MCMBP",1.065612343,0.083830719,"nochange",21791.5,20572.1,20153.6,22861,22032.4,21725.7,1.012488355,0.955831939,0.936387367,1.062180038,1.02368118,1.00943112,"cytoplasm",{"$nulls":3},"GO:0000819 sister chromatid segregation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007062 sister chromatid cohesion; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0051276 chromosome organization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0098813 nuclear chromosome segregation; GO:1901360 organic cyclic compound metabolic process; GO:1901576 organic substance biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042555 MCM complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0003682 chromatin binding; GO:0005488 binding;",null,null,"S","KOG2545","Conserved membrane protein"]
["Q9BUB5","MAP kinase-interacting serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=MKNK1 PE=1 SV=1","MKNK1",0.555291336,1.518772E-3,"down",6154.37,5480.54,4841.27,3231.13,3002.86,2915.09,1.441008599,1.28323537,1.133554157,0.756549592,0.703101549,0.682550733,"nucleus","K04372","MKNK; MAP kinase interacting serine/threonine kinase [EC:2.7.11.1]","hsa04066 HIF-1 signaling pathway; hsa04910 Insulin signaling pathway; hsa04010 MAPK signaling pathway","GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006417 regulation of translation; GO:0006446 regulation of translational initiation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006970 response to osmotic stress; GO:0007017 microtubule-based process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007610 behavior; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008340 determination of adult lifespan; GO:0009628 response to abiotic stimulus; GO:0009636 response to toxic substance; GO:0009651 response to salt stress; GO:0009889 regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0012501 programmed cell death; GO:0016310 phosphorylation; GO:0018105 peptidyl-serine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018209 peptidyl-serine modification; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030097 hemopoiesis; GO:0030162 regulation of proteolysis; GO:0030534 adult behavior; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033135 regulation of peptidyl-serine phosphorylation; GO:0033138 positive regulation of peptidyl-serine phosphorylation; GO:0034248 regulation of cellular amide metabolic process; GO:0035094 response to nicotine; GO:0035095 behavioral response to nicotine; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0038034 signal transduction in absence of ligand; GO:0040008 regulation of growth; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045937 positive regulation of phosphate metabolic process; GO:0046578 regulation of Ras protein signal transduction; GO:0046580 negative regulation of Ras protein signal transduction; GO:0046685 response to arsenic-containing substance; GO:0046777 protein autophosphorylation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051058 negative regulation of small GTPase mediated signal transduction; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060625 regulation of protein deneddylation; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071243 cellular response to arsenic-containing substance; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097191 extrinsic apoptotic signaling pathway; GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016604 nuclear body; GO:0016605 PML body; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0004683 calmodulin-dependent protein kinase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0005524 ATP binding; GO:0009931 calcium-dependent protein serine/threonine kinase activity; GO:0010857 calcium-dependent protein kinase activity; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0051019 mitogen-activated protein kinase binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00069","PF00069 Protein kinase domain","T","KOG0607","MAP kinase-interacting kinase and related serine/threonine protein kinases","WP3879 4HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION;WP3676 BDNFTRKB SIGNALING;WP4549 FRAGILE X SYNDROME;WP2637 INTERLEUKIN1 IL1 STRUCTURAL PATHWAY;WP5087 MALIGNANT PLEURAL MESOTHELIOMA;WP382 MAPK SIGNALING PATHWAY;WP400 P38 MAPK SIGNALING PATHWAY;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3879_r120671;http://www.wikipathways.org/instance/WP3676_r116809;http://www.wikipathways.org/instance/WP4549_r119333;http://www.wikipathways.org/instance/WP2637_r117962;http://www.wikipathways.org/instance/WP5087_r120373;http://www.wikipathways.org/instance/WP382_r119087;http://www.wikipathways.org/instance/WP400_r116725;http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-1295596 Spry regulation of FGF signaling;R-HSA-162582 Signal Transduction;R-HSA-190236 Signaling by FGFR;R-HSA-5654726 Negative regulation of FGFR1 signaling;R-HSA-5654727 Negative regulation of FGFR2 signaling;R-HSA-5654732 Negative regulation of FGFR3 signaling;R-HSA-5654733 Negative regulation of FGFR4 signaling;R-HSA-5654736 Signaling by FGFR1;R-HSA-5654738 Signaling by FGFR2;R-HSA-5654741 Signaling by FGFR3;R-HSA-5654743 Signaling by FGFR4;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases","https://reactome.org/PathwayBrowser/#/R-HSA-1295596;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-190236;https://reactome.org/PathwayBrowser/#/R-HSA-5654726;https://reactome.org/PathwayBrowser/#/R-HSA-5654727;https://reactome.org/PathwayBrowser/#/R-HSA-5654732;https://reactome.org/PathwayBrowser/#/R-HSA-5654733;https://reactome.org/PathwayBrowser/#/R-HSA-5654736;https://reactome.org/PathwayBrowser/#/R-HSA-5654738;https://reactome.org/PathwayBrowser/#/R-HSA-5654741;https://reactome.org/PathwayBrowser/#/R-HSA-5654743;https://reactome.org/PathwayBrowser/#/R-HSA-9006934","PI3K AKT MTOR SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING"]
["Q9BUR4","Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1","WRAP53",1.278039288,0.004223661,"up",4147.32,4701.37,4388.54,5421.19,5830.7,5665.81,0.82520238,0.93544306,0.873198512,1.078667402,1.160148606,1.12734004,"nucleus","K23314",null,null,"GO:0000723 telomere maintenance; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006278 RNA-dependent DNA biosynthetic process; GO:0006403 RNA localization; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0007004 telomere maintenance via telomerase; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010833 telomere maintenance via telomere lengthening; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022607 cellular component assembly; GO:0030575 nuclear body organization; GO:0030576 Cajal body organization; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032200 telomere organization; GO:0032202 telomere assembly; GO:0032203 telomere formation via telomerase; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042592 homeostatic process; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051276 chromosome organization; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051641 cellular localization; GO:0051972 regulation of telomerase activity; GO:0051973 positive regulation of telomerase activity; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070202 regulation of establishment of protein localization to chromosome; GO:0070203 regulation of establishment of protein localization to telomere; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0090666 scaRNA localization to Cajal body; GO:0090670 RNA localization to Cajal body; GO:0090671 telomerase RNA localization to Cajal body; GO:0090672 telomerase RNA localization; GO:0090685 RNA localization to nucleus; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903405 protein localization to nuclear body; GO:1903829 positive regulation of protein localization; GO:1904814 regulation of protein localization to chromosome"," telomeric region; GO:1904816 positive regulation of protein localization to chromosome"," telomeric region; GO:1904851 positive regulation of establishment of protein localization to telomere; GO:1904867 protein localization to Cajal body; GO:1904951 positive regulation of establishment of protein localization; GO:1990173 protein localization to nucleoplasm; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000573 positive regulation of DNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005697 telomerase holoenzyme complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0015030 Cajal body; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0030515 snoRNA binding; GO:0034512 box C/D RNA binding; GO:0042802 identical protein binding; GO:0044877 protein-containing complex binding; GO:0051087 chaperone binding; GO:0070034 telomerase RNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG2919","Guanine nucleotide-binding protein",{"$nulls":3},"R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-171319 Telomere Extension By Telomerase;R-HSA-180786 Extension of Telomeres;R-HSA-390466 Chaperonin-mediated protein folding;R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins;R-HSA-73886 Chromosome Maintenance","https://reactome.org/PathwayBrowser/#/R-HSA-157579;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-171319;https://reactome.org/PathwayBrowser/#/R-HSA-180786;https://reactome.org/PathwayBrowser/#/R-HSA-390466;https://reactome.org/PathwayBrowser/#/R-HSA-390471;https://reactome.org/PathwayBrowser/#/R-HSA-391251;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-73886"]
["Q9BV44","tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1","THUMPD3",0.625046284,0.00169419,"down",23335.8,24384.2,21958.2,16137.9,13916.3,13497.9,1.236548874,1.292102909,1.163550746,0.855136832,0.737415692,0.715244948,"cytoplasm",{"$nulls":3},"GO:0001510 RNA methylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006400 tRNA modification; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0030488 tRNA methylation; GO:0032259 methylation; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0008168 methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008175 tRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016423 tRNA (guanine) methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF02926; PF01170","PF02926 THUMP domain; PF01170 Putative RNA methylase family UPF0020"]
["Q9BVJ7","Dual specificity protein phosphatase 23 OS=Homo sapiens OX=9606 GN=DUSP23 PE=1 SV=1","DUSP23",0.691280013,0.003748723,"down",27700.8,24785.2,22859.3,16573.8,17941.5,17569.4,1.304283136,1.167003061,1.076322687,0.780371969,0.844769677,0.82724947,"cytoplasm","K14165",null,null,"GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016311 dephosphorylation; GO:0019538 protein metabolic process; GO:0035335 peptidyl-tyrosine dephosphorylation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004721 phosphoprotein phosphatase activity; GO:0004722 protein serine/threonine phosphatase activity; GO:0004725 protein tyrosine phosphatase activity; GO:0008138 protein tyrosine/serine/threonine phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0140096 catalytic activity"," acting on a protein;","PF00782","PF00782 Dual specificity phosphatase"," catalytic domain","V","KOG1720","Protein tyrosine phosphatase CDC14"]
["Q9BVP2","Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2","GNL3",0.702848607,1.95248E-4,"down",44546.1,43626.3,42365.1,29720.2,30060.9,31967,1.202401775,1.177574256,1.143531565,0.802216608,0.811412885,0.862862911,"nucleus","K14538","NUG1; nuclear GTP-binding protein","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000459 exonucleolytic trimming involved in rRNA processing; GO:0000460 maturation of 5.8S rRNA; GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000469 cleavage involved in rRNA processing; GO:0001654 eye development; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0003407 neural retina development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007088 regulation of mitotic nuclear division; GO:0007096 regulation of exit from mitosis; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0017145 stem cell division; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030154 cell differentiation; GO:0031123 RNA 3'-end processing; GO:0031125 rRNA 3'-end processing; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032091 negative regulation of protein binding; GO:0032092 positive regulation of protein binding; GO:0032204 regulation of telomere maintenance; GO:0032205 negative regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032211 negative regulation of telomere maintenance via telomerase; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033233 regulation of protein sumoylation; GO:0033234 negative regulation of protein sumoylation; GO:0033235 positive regulation of protein sumoylation; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0042127 regulation of cell population proliferation; GO:0042254 ribosome biogenesis; GO:0042273 ribosomal large subunit biogenesis; GO:0043010 camera-type eye development; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043496 regulation of protein homodimerization activity; GO:0043628 ncRNA 3'-end processing; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051225 spindle assembly; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051301 cell division; GO:0051726 regulation of cell cycle; GO:0051783 regulation of nuclear division; GO:0051960 regulation of nervous system development; GO:0060041 retina development in camera-type eye; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090073 positive regulation of protein homodimerization activity; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090307 mitotic spindle assembly; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090503 RNA phosphodiester bond hydrolysis"," exonucleolytic; GO:0098727 maintenance of cell number; GO:0140014 mitotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1901987 regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902893 regulation of miRNA transcription; GO:1902895 positive regulation of miRNA transcription; GO:1903047 mitotic cell cycle process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903829 positive regulation of protein localization; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904357 negative regulation of telomere maintenance via telomere lengthening; GO:1904814 regulation of protein localization to chromosome"," telomeric region; GO:1904816 positive regulation of protein localization to chromosome"," telomeric region; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000279 negative regulation of DNA biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0001652 granular component; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005697 telomerase holoenzyme complex; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005525 GTP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0048027 mRNA 5'-UTR binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG2484","GTPase",{"$nulls":3},"R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V1;MYC TARGETS V2","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2"]
["Q9BW83","Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1","IFT27",0.488119533,0.001542558,"down",14073.5,12277.3,10733.6,5754.86,5695.34,6651.42,1.530115779,1.33482719,1.166991205,0.625686723,0.619215519,0.723163584,"cytoplasm","K07934",null,null,"GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0008104 protein localization; GO:0009987 cellular process; GO:0010970 transport along microtubule; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031175 neuron projection development; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0035735 intraciliary transport involved in cilium assembly; GO:0042073 intraciliary transport; GO:0042490 mechanoreceptor differentiation; GO:0042886 amide transport; GO:0043583 ear development; GO:0044085 cellular component biogenesis; GO:0044782 cilium organization; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060113 inner ear receptor cell differentiation; GO:0060119 inner ear receptor cell development; GO:0060122 inner ear receptor cell stereocilium organization; GO:0060271 cilium assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0090102 cochlea development; GO:0099111 microtubule-based transport; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005929 cilium; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0030990 intraciliary transport particle; GO:0030992 intraciliary transport particle B; GO:0031410 cytoplasmic vesicle; GO:0031514 motile cilium; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036126 sperm flagellum; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0097225 sperm midpiece; GO:0097228 sperm principal piece; GO:0097542 ciliary tip; GO:0097708 intracellular vesicle; GO:0097729 9+2 motile cilium; GO:0120025 plasma membrane bounded cell projection;",null,"PF00071","PF00071 Ras family","R","KOG0079","GTP-binding protein H-ray"," small G protein superfamily","WP4352 CILIARY LANDSCAPE;WP4803 CILIOPATHIES;WP4830 GDNFRET SIGNALING AXIS;WP4536 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR;WP4532 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP4803_r110008;http://www.wikipathways.org/instance/WP4830_r118773;http://www.wikipathways.org/instance/WP4536_r110928;http://www.wikipathways.org/instance/WP4532_r103287",null,"R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-5617833 Cilium Assembly;R-HSA-5620924 Intraflagellar transport","https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620924"]
["Q9BX70","BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=BTBD2 PE=1 SV=1","BTBD2",0.99395581,0.966377498,"nochange",3248.5,3951.22,3266.53,3386.51,3735.82,3280.66,0.933958304,1.135993453,0.93914201,0.973636798,1.074064988,0.943204448,"nucleus","K10477",null,null,"GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022008 neurogenesis; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0036211 protein modification process; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0051098 regulation of binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000151 ubiquitin ligase complex; GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0019005 SCF ubiquitin ligase complex; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:1902494 catalytic complex; GO:1990234 transferase complex; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding;","PF00651; PF07707; PF08005","PF00651 BTB/POZ domain; PF07707 BTB And C-terminal Kelch; PF08005 PHR domain ","S","KOG2075","Topoisomerase TOP1-interacting protein BTBD1"]
["Q9BXK5","Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1","BCL2L13",0.918841664,0.464551831,"nochange",19464.6,24491.5,24507.6,18315.9,21344,23247.4,0.888990721,1.118580204,1.119315526,0.836527087,0.974827017,1.061759445,"cytoplasm","K15485","BCL2L13; Bcl-2-like protein 13","hsa05134 Legionellosis; hsa04137 Mitophagy - animal","GO:0006915 apoptotic process; GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0008219 cell death; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0012501 programmed cell death; GO:0019222 regulation of metabolic process; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0044093 positive regulation of molecular function; GO:0045862 positive regulation of proteolysis; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0080090 regulation of primary metabolic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2001056 positive regulation of cysteine-type endopeptidase activity;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0008047 enzyme activator activity; GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process; GO:0016504 peptidase activator activity; GO:0016505 peptidase activator activity involved in apoptotic process; GO:0030234 enzyme regulator activity; GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process; GO:0061134 peptidase regulator activity; GO:0098772 molecular function regulator;",{"$nulls":5},"WP3872 REGULATION OF APOPTOSIS BY PARATHYROID HORMONERELATED PROTEIN","http://www.wikipathways.org/instance/WP3872_r116648",{"$nulls":3},"ADIPOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS"]
["Q9BXW9","Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2","FANCD2",0.385300349,0.000341108,"down",17026.6,15496,15904.4,7234.98,5817.48,5606.48,1.522816853,1.385923787,1.422450069,0.647078658,0.520300975,0.501429659,"nucleus","K10891","FANCD2; fanconi anemia group D2 protein","hsa03460 Fanconi anemia pathway","GO:0000003 reproduction; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0002682 regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006355 regulation of transcription"," DNA-templated; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007127 meiosis I; GO:0007129 homologous chromosome pairing at meiosis; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010212 response to ionizing radiation; GO:0010332 response to gamma radiation; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010646 regulation of cell communication; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031570 DNA integrity checkpoint signaling; GO:0031573 mitotic intra-S DNA damage checkpoint signaling; GO:0032101 regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033554 cellular response to stress; GO:0034599 cellular response to oxidative stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036297 interstrand cross-link repair; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0045132 meiotic chromosome segregation; GO:0045143 homologous chromosome segregation; GO:0045580 regulation of T cell differentiation; GO:0045589 regulation of regulatory T cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045619 regulation of lymphocyte differentiation; GO:0045786 negative regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0046483 heterocycle metabolic process; GO:0048285 organelle fission; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048854 brain morphogenesis; GO:0048856 anatomical structure development; GO:0050727 regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051249 regulation of lymphocyte activation; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051321 meiotic cell cycle; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0061982 meiosis I cell cycle process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070887 cellular response to chemical stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:0097150 neuronal stem cell population maintenance; GO:0098727 maintenance of cell number; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1902105 regulation of leukocyte differentiation; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000348 regulation of CD40 signaling pathway; GO:2001141 regulation of RNA biosynthetic process;","GO:0000793 condensed chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0070182 DNA polymerase binding;",null,null,"S","KOG4712","Uncharacterized conserved protein","WP4942 15Q133 COPY NUMBER VARIATION SYNDROME;WP2516 ATM SIGNALING PATHWAY;WP707 DNA DAMAGE RESPONSE;WP4016 DNA IRDAMAGE AND CELLULAR RESPONSE VIA ATR;WP3959 DNA IRDOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP1530 MIRNA REGULATION OF DNA DAMAGE RESPONSE","http://www.wikipathways.org/instance/WP4942_r115789;http://www.wikipathways.org/instance/WP2516_r116808;http://www.wikipathways.org/instance/WP707_r116541;http://www.wikipathways.org/instance/WP4016_r120667;http://www.wikipathways.org/instance/WP3959_r118468;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP1530_r118120","Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-3700989 Transcriptional Regulation by TP53;R-HSA-6783310 Fanconi Anemia Pathway;R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-73894 DNA Repair;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-3700989;https://reactome.org/PathwayBrowser/#/R-HSA-6783310;https://reactome.org/PathwayBrowser/#/R-HSA-6796648;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["Q9BYT8","Neurolysin"," mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1","NLN",0.920239362,0.016330541,"nochange",31679.4,30084.2,30214.1,28914.6,27731.7,27995.2,1.076193302,1.022002138,1.026415022,0.982269198,0.942084439,0.951035901,"mitochondria","K01393","NLN; neurolysin [EC:3.4.24.16]","hsa04614 Renin-angiotensin system","GO:0000209 protein polyubiquitination; GO:0006109 regulation of carbohydrate metabolic process; GO:0006111 regulation of gluconeogenesis; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010830 regulation of myotube differentiation; GO:0010906 regulation of glucose metabolic process; GO:0016202 regulation of striated muscle tissue development; GO:0016567 protein ubiquitination; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043255 regulation of carbohydrate biosynthetic process; GO:0043412 macromolecule modification; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0048634 regulation of muscle organ development; GO:0048641 regulation of skeletal muscle tissue development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051147 regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051239 regulation of multicellular organismal process; GO:0062012 regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901861 regulation of muscle tissue development; GO:1902809 regulation of skeletal muscle fiber differentiation; GO:2000026 regulation of multicellular organismal development; GO:2001014 regulation of skeletal muscle cell differentiation;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005758 mitochondrial intermembrane space; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0003824 catalytic activity; GO:0004175 endopeptidase activity; GO:0004222 metalloendopeptidase activity; GO:0005488 binding; GO:0008233 peptidase activity; GO:0008237 metallopeptidase activity; GO:0016787 hydrolase activity; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0070012 oligopeptidase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"O","KOG2089","Metalloendopeptidase family - saccharolysin & thimet oligopeptidase",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-372790 Signaling by GPCR;R-HSA-373076 Class A/1 (Rhodopsin-like receptors);R-HSA-375276 Peptide ligand-binding receptors;R-HSA-500792 GPCR ligand binding","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-372790;https://reactome.org/PathwayBrowser/#/R-HSA-373076;https://reactome.org/PathwayBrowser/#/R-HSA-375276;https://reactome.org/PathwayBrowser/#/R-HSA-500792"]
["Q9BZL1","Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1","UBL5",1.53442134,1.302325E-3,"up",12166.1,12740.5,11306.4,17083,19487.7,18995.3,0.795351878,0.832902952,0.739149479,1.116791423,1.27399732,1.241806949,"extracellular","K13113",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031347 regulation of defense response; GO:0031349 positive regulation of defense response; GO:0033554 cellular response to stress; GO:0034121 regulation of toll-like receptor signaling pathway; GO:0034123 positive regulation of toll-like receptor signaling pathway; GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway; GO:0034126 positive regulation of MyD88-dependent toll-like receptor signaling pathway; GO:0034514 mitochondrial unfolded protein response; GO:0034620 cellular response to unfolded protein; GO:0034641 cellular nitrogen compound metabolic process; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036211 protein modification process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045088 regulation of innate immune response; GO:0045089 positive regulation of innate immune response; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050778 positive regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071704 organic substance metabolic process; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005667 transcription regulator complex; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0031386 protein tag;","PF00240","PF00240 Ubiquitin family","O","KOG3493","Ubiquitin-like protein"]
["Q9BZQ6","ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2","EDEM3",1.250774887,0.022237028,"nochange",15217.9,16797.3,18250.2,20142.5,22366.3,20361.9,0.807058048,0.890819111,0.96787144,1.068226676,1.186162507,1.079862219,"mitochondria","K10086","EDEM3; ER degradation enhancer"," mannosidase alpha-like 3","hsa04141 Protein processing in endoplasmic reticulum","GO:0006464 cellular protein modification process; GO:0006491 N-glycan processing; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006516 glycoprotein catabolic process; GO:0006517 protein deglycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0023052 signaling; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0033554 cellular response to stress; GO:0034620 cellular response to unfolded protein; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0035977 protein deglycosylation involved in glycoprotein catabolic process; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0036507 protein demannosylation; GO:0036508 protein alpha-1","2-demannosylation; GO:0042221 response to chemical; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071704 organic substance metabolic process; GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1904382 mannose trimming involved in glycoprotein ERAD pathway; GO:1904587 response to glycoprotein;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0012505 endomembrane system; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044322 endoplasmic reticulum quality control compartment; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0004559 alpha-mannosidase activity; GO:0004571 mannosyl-oligosaccharide 1","2-alpha-mannosidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0015923 mannosidase activity; GO:0015924 mannosyl-oligosaccharide mannosidase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0051082 unfolded protein binding;",null,null,"G","KOG2430","Glycosyl hydrolase"," family 47",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle;R-HSA-597592 Post-translational protein modification;R-HSA-901032 ER Quality Control Compartment (ERQC);R-HSA-901042 Calnexin/calreticulin cycle","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-532668;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-901032;https://reactome.org/PathwayBrowser/#/R-HSA-901042"]
["Q9C0E8","Endoplasmic reticulum junction formation protein lunapark OS=Homo sapiens OX=9606 GN=LNPK PE=1 SV=2","LNPK",1.486470515,0.000109946,"up",17358.7,18715.3,18754.4,26839.2,27288.6,27373,0.763975729,0.823681207,0.825402042,1.181223098,1.201001693,1.204716231,"plasma membrane","K23292",null,null,"GO:0006810 transport; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007029 endoplasmic reticulum organization; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030326 embryonic limb morphogenesis; GO:0032330 regulation of chondrocyte differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0035107 appendage morphogenesis; GO:0035108 limb morphogenesis; GO:0035113 embryonic appendage morphogenesis; GO:0035115 embryonic forelimb morphogenesis; GO:0035136 forelimb morphogenesis; GO:0042060 wound healing; GO:0042733 embryonic digit morphogenesis; GO:0043954 cellular component maintenance; GO:0044085 cellular component biogenesis; GO:0045595 regulation of cell differentiation; GO:0046662 regulation of oviposition; GO:0046907 intracellular transport; GO:0048489 synaptic vesicle transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048598 embryonic morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050803 regulation of synapse structure or activity; GO:0050808 synapse organization; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0060173 limb development; GO:0061035 regulation of cartilage development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071786 endoplasmic reticulum tubular network organization; GO:0071788 endoplasmic reticulum tubular network maintenance; GO:0071840 cellular component organization or biogenesis; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0098916 anterograde trans-synaptic signaling; GO:0099003 vesicle-mediated transport in synapse; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:1903371 regulation of endoplasmic reticulum tubular network organization; GO:1903373 positive regulation of endoplasmic reticulum tubular network organization; GO:2000026 regulation of multicellular organismal development; GO:2000241 regulation of reproductive process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030133 transport vesicle; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0036477 somatodendritic compartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0045202 synapse; GO:0070013 intracellular organelle lumen; GO:0070382 exocytic vesicle; GO:0071782 endoplasmic reticulum tubular network; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0098826 endoplasmic reticulum tubular network membrane; GO:0098827 endoplasmic reticulum subcompartment; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;",null,null,"S","KOG2846","Predicted membrane protein"]
["Q9GZP9","Derlin-2 OS=Homo sapiens OX=9606 GN=DERL2 PE=1 SV=1","DERL2",1.513077274,0.104336575,"nochange",17203.7,18522.7,11668.8,17916.2,25764.6,28031.8,0.866628382,0.933072393,0.58781037,0.902520238,1.297879736,1.412088881,"plasma membrane","K13989","DERL2_3; Derlin-2/3","hsa04141 Protein processing in endoplasmic reticulum","GO:0001558 regulation of cell growth; GO:0001967 suckling behavior; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006517 protein deglycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006986 response to unfolded protein; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007610 behavior; GO:0007631 feeding behavior; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0023052 signaling; GO:0030162 regulation of proteolysis; GO:0030163 protein catabolic process; GO:0030307 positive regulation of cell growth; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0030970 retrograde protein transport"," ER to cytosol; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032527 protein exit from endoplasmic reticulum; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033157 regulation of intracellular protein transport; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0034620 cellular response to unfolded protein; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036211 protein modification process; GO:0036503 ERAD pathway; GO:0036507 protein demannosylation; GO:0036508 protein alpha-1","2-demannosylation; GO:0040008 regulation of growth; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042742 defense response to bacterium; GO:0042886 amide transport; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0045861 negative regulation of proteolysis; GO:0045927 positive regulation of growth; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070861 regulation of protein exit from endoplasmic reticulum; GO:0070862 negative regulation of protein exit from endoplasmic reticulum; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090087 regulation of peptide transport; GO:0090317 negative regulation of intracellular protein transport; GO:0098542 defense response to other organism; GO:1901135 carbohydrate derivative metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903513 endoplasmic reticulum to cytosol transport; GO:1903573 negative regulation of response to endoplasmic reticulum stress; GO:1903828 negative regulation of protein localization; GO:1904152 regulation of retrograde protein transport"," ER to cytosol; GO:1904153 negative regulation of retrograde protein transport"," ER to cytosol; GO:1904292 regulation of ERAD pathway; GO:1904293 negative regulation of ERAD pathway; GO:1904380 endoplasmic reticulum mannose trimming; GO:1904950 negative regulation of establishment of protein localization; GO:1905897 regulation of response to endoplasmic reticulum stress;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle; GO:0098827 endoplasmic reticulum subcompartment;",{"$nulls":3},"S","KOG0858","Predicted membrane protein",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle;R-HSA-5358346 Hedgehog ligand biogenesis;R-HSA-5358351 Signaling by Hedgehog;R-HSA-5362768 Hh mutants are degraded by ERAD;R-HSA-5387390 Hh mutants abrogate ligand secretion;R-HSA-5619084 ABC transporter disorders;R-HSA-5619115 Disorders of transmembrane transporters;R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers;R-HSA-5678895 Defective CFTR causes cystic fibrosis;R-HSA-597592 Post-translational protein modification;R-HSA-901032 ER Quality Control Compartment (ERQC);R-HSA-901042 Calnexin/calreticulin cycle","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-382556;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-532668;https://reactome.org/PathwayBrowser/#/R-HSA-5358346;https://reactome.org/PathwayBrowser/#/R-HSA-5358351;https://reactome.org/PathwayBrowser/#/R-HSA-5362768;https://reactome.org/PathwayBrowser/#/R-HSA-5387390;https://reactome.org/PathwayBrowser/#/R-HSA-5619084;https://reactome.org/PathwayBrowser/#/R-HSA-5619115;https://reactome.org/PathwayBrowser/#/R-HSA-5663202;https://reactome.org/PathwayBrowser/#/R-HSA-5678895;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-901032;https://reactome.org/PathwayBrowser/#/R-HSA-901042"]
["Q9H063","Repressor of RNA polymerase III transcription MAF1 homolog OS=Homo sapiens OX=9606 GN=MAF1 PE=1 SV=2","MAF1",0.631035973,0.039018905,"nochange",2588.12,3580.27,2760.99,1542.45,2304.26,1788.05,1.066229795,1.474966596,1.137447182,0.635444317,0.949287771,0.736624339,"cytoplasm","nucleus","K25817",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006359 regulation of transcription by RNA polymerase III; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016480 negative regulation of transcription by RNA polymerase III; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0060077 inhibitory synapse; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection;","GO:0000182 rDNA binding; GO:0000994 RNA polymerase III core binding; GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0043175 RNA polymerase core enzyme binding; GO:0043565 sequence-specific DNA binding; GO:0050811 GABA receptor binding; GO:0070063 RNA polymerase binding; GO:0080084 5S rDNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;",null,null,"K","KOG3104","Mod5 protein sorting/negative effector of RNA Pol III synthesis",{"$nulls":3},"R-HSA-1257604 PIP3 activates AKT signaling;R-HSA-162582 Signal Transduction;R-HSA-6807070 PTEN Regulation;R-HSA-8943724 Regulation of PTEN gene transcription;R-HSA-9006925 Intracellular signaling by second messengers","https://reactome.org/PathwayBrowser/#/R-HSA-1257604;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-6807070;https://reactome.org/PathwayBrowser/#/R-HSA-8943724;https://reactome.org/PathwayBrowser/#/R-HSA-9006925"]
["Q9H0R1","AP-5 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP5M1 PE=1 SV=2","AP5M1",0.830832467,0.64908771,"nochange",4826.57,2684.58,6366.04,3077.27,4316.79,4135.56,1.139829046,0.633982779,1.503385903,0.726719332,1.019440851,0.976642089,"mitochondria","K19023",null,null,"GO:0006810 transport; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048475 coated membrane; GO:0097708 intracellular vesicle; GO:0098796 membrane protein complex;",{"$nulls":3},"U","KOG0937","Adaptor complexes medium subunit family"]
["Q9H0S4","Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1","DDX47",1.140657741,0.038150071,"nochange",61680.2,57029.1,63164.8,68329.3,65986.1,73140.7,0.950558677,0.87888019,0.973437971,1.053028509,1.016917259,1.127177393,"nucleus","K14777",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008152 metabolic process; GO:0008219 cell death; GO:0008380 RNA splicing; GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010501 RNA secondary structure unwinding; GO:0012501 programmed cell death; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0023052 signaling; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097191 extrinsic apoptotic signaling pathway; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003724 RNA helicase activity; GO:0003824 catalytic activity; GO:0004386 helicase activity; GO:0008186 ATP-dependent activity"," acting on RNA; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0140098 catalytic activity"," acting on RNA;","PF00270; PF00271","PF00270 DEAD/DEAH box helicase; PF00271 Helicase conserved C-terminal domain","A","KOG0330","ATP-dependent RNA helicase",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9H1K1","Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2","ISCU",0.912044138,0.022843648,"nochange",11918.8,11551,12127.6,11126.2,10966.7,10373.5,1.050673045,1.018250524,1.069079305,0.980803305,0.966742968,0.914450853,"mitochondria","K22068",null,null,"GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006873 cellular ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0006879 cellular iron ion homeostasis; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016226 iron-sulfur cluster assembly; GO:0019538 protein metabolic process; GO:0019725 cellular homeostasis; GO:0022607 cellular component assembly; GO:0030003 cellular cation homeostasis; GO:0031163 metallo-sulfur cluster assembly; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0046916 cellular transition metal ion homeostasis; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0051604 protein maturation; GO:0055065 metal ion homeostasis; GO:0055072 iron ion homeostasis; GO:0055076 transition metal ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0097428 protein maturation by iron-sulfur cluster transfer; GO:0098771 inorganic ion homeostasis; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990221 L-cysteine desulfurase complex;","GO:0003824 catalytic activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005506 iron ion binding; GO:0005515 protein binding; GO:0008198 ferrous iron binding; GO:0016740 transferase activity; GO:0016782 transferase activity"," transferring sulphur-containing groups; GO:0036455 iron-sulfur transferase activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051536 iron-sulfur cluster binding; GO:0051537 2 iron"," 2 sulfur cluster binding; GO:0051539 4 iron"," 4 sulfur cluster binding; GO:0051540 metal cluster binding;",null,null,"C","KOG3361","Iron binding protein involved in Fe-S cluster formation",{"$nulls":3},"R-HSA-1643685 Disease;R-HSA-5663205 Infectious disease;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694301 Maturation of replicase proteins;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex;R-HSA-9772572 Early SARS-CoV-2 Infection Events","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694301;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9694676;https://reactome.org/PathwayBrowser/#/R-HSA-9772572","COAGULATION;OXIDATIVE PHOSPHORYLATION;P53 PATHWAY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COAGULATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY"]
["Q9H269","Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2","VPS16",0.914110522,0.076240277,"nochange",16049.8,14497.7,15997.2,14524.4,13721.4,14301.2,1.080895302,0.976367047,1.077352885,0.978165194,0.924086082,0.963133491,"nucleus","K20180","VPS16; vacuolar protein sorting-associated protein 16","hsa05132 Salmonella infection","GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006914 autophagy; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007034 vacuolar transport; GO:0007041 lysosomal transport; GO:0007154 cell communication; GO:0007275 multicellular organism development; GO:0008057 eye pigment granule organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008333 endosome to lysosome transport; GO:0008593 regulation of Notch signaling pathway; GO:0009056 catabolic process; GO:0009267 cellular response to starvation; GO:0009605 response to external stimulus; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016032 viral process; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016236 macroautophagy; GO:0019058 viral life cycle; GO:0022411 cellular component disassembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0031338 regulation of vesicle fusion; GO:0031667 response to nutrient levels; GO:0031668 cellular response to extracellular stimulus; GO:0031669 cellular response to nutrient levels; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032889 regulation of vacuole fusion"," non-autophagic; GO:0032984 protein-containing complex disassembly; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033059 cellular pigmentation; GO:0033554 cellular response to stress; GO:0034613 cellular protein localization; GO:0035295 tube development; GO:0035542 regulation of SNARE complex assembly; GO:0042594 response to starvation; GO:0042886 amide transport; GO:0043254 regulation of protein-containing complex assembly; GO:0043473 pigmentation; GO:0043933 protein-containing complex organization; GO:0044087 regulation of cellular component biogenesis; GO:0044088 regulation of vacuole organization; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0044403 biological process involved in symbiotic interaction; GO:0044409 entry into host; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045184 establishment of protein localization; GO:0045746 negative regulation of Notch signaling pathway; GO:0046718 viral entry into host cell; GO:0046907 intracellular transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048565 digestive tract development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048731 system development; GO:0048753 pigment granule organization; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051701 biological process involved in interaction with host; GO:0051716 cellular response to stimulus; GO:0055123 digestive system development; GO:0060627 regulation of vesicle-mediated transport; GO:0061919 process utilizing autophagic mechanism; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071496 cellular response to external stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0097352 autophagosome maturation;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005768 endosome; GO:0005769 early endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005776 autophagosome; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030424 axon; GO:0030897 HOPS complex; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0033263 CORVET complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044297 cell body; GO:0055037 recycling endosome; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098852 lytic vacuole membrane; GO:0099023 vesicle tethering complex; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;",null,null,"U","KOG2280","Vacuolar assembly/sorting protein VPS16","WP4217 EBOLA VIRUS INFECTION IN HOST;WP5115 NETWORK MAP OF SARSCOV2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4217_r120623;http://www.wikipathways.org/instance/WP5115_r120597",null,"R-HSA-1643685 Disease;R-HSA-5663205 Infectious disease;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-9754560 SARS-CoV-2 modulates autophagy","https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-9679506;https://reactome.org/PathwayBrowser/#/R-HSA-9694516;https://reactome.org/PathwayBrowser/#/R-HSA-9705683;https://reactome.org/PathwayBrowser/#/R-HSA-9754560"]
["Q9H307","Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5","PNN",1.56452031,0.000131687,"up",51082.9,56489.2,52916.9,85274.9,82958.5,82854.9,0.744689758,0.823503143,0.771425927,1.243142904,1.209374278,1.207863991,"nucleus","K13114","PNN; pinin","hsa03013 Nucleocytoplasmic transport; hsa03015 mRNA surveillance pathway","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007155 cell adhesion; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0022610 biological adhesion; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0098609 cell-cell adhesion; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005882 intermediate filament; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0016020 membrane; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0030054 cell junction; GO:0030057 desmosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035145 exon-exon junction complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045111 intermediate filament cytoskeleton; GO:0070013 intracellular organelle lumen; GO:0070161 anchoring junction; GO:0071013 catalytic step 2 spliceosome; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0005198 structural molecule activity;",null,null,"Z","KOG3756","Pinin (desmosome-associated protein)",{"$nulls":5},"E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["Q9H3U5","Major facilitator superfamily domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MFSD1 PE=2 SV=2","MFSD1",0.522006196,0.053463692,"nochange",9493.42,8478.22,12419.8,7896.78,3860.48,4107.26,1.231420124,1.099735472,1.611009695,1.024315137,0.500754497,0.532765075,"plasma membrane",{"$nulls":8},"G","KOG4686","Predicted sugar transporter"]
["Q9H490","Phosphatidylinositol glycan anchor biosynthesis class U protein OS=Homo sapiens OX=9606 GN=PIGU PE=1 SV=3","PIGU",0.604966704,8.33119E-4,"down",21712.5,22962.4,21759.5,13124.8,12314.9,14750.9,1.221805393,1.292139742,1.224450176,0.738558499,0.692983822,0.830062368,"plasma membrane","K05293","PIGU; GPI-anchor transamidase subunit U","hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; hsa01100 Metabolic pathways","GO:0006464 cellular protein modification process; GO:0006497 protein lipidation; GO:0006505 GPI anchor metabolic process; GO:0006506 GPI anchor biosynthetic process; GO:0006629 lipid metabolic process; GO:0006643 membrane lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006664 glycolipid metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009247 glycolipid biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0016255 attachment of GPI anchor to protein; GO:0019538 protein metabolic process; GO:0019637 organophosphate metabolic process; GO:0023051 regulation of signaling; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0042157 lipoprotein metabolic process; GO:0042158 lipoprotein biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046467 membrane lipid biosynthetic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0048583 regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1903509 liposaccharide metabolic process; GO:1904892 regulation of receptor signaling pathway via STAT;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042765 GPI-anchor transamidase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment; GO:1902494 catalytic complex;",{"$nulls":3},"R","KOG2552","Major facilitator superfamily permease - Cdc91p",{"$nulls":3},"R-HSA-162791 Attachment of GPI anchor to uPAR;R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins;R-HSA-392499 Metabolism of proteins;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-162791;https://reactome.org/PathwayBrowser/#/R-HSA-163125;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q9H4M9","EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2","EHD1",1.20521519,{"v":9.82196e-05,"d":"9.82E-05"},"up",47994.3,48483.9,48521.3,57017.6,59290.1,58447.9,0.900582352,0.909769383,0.91047117,1.069898807,1.112540816,1.096737472,"cytoplasm","K12483","EHD1; EH domain-containing protein 1","hsa04144 Endocytosis","GO:0000003 reproduction; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001754 eye photoreceptor cell differentiation; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0003407 neural retina development; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007283 spermatogenesis; GO:0007286 spermatid development; GO:0007291 sperm individualization; GO:0007292 female gamete generation; GO:0007349 cellularization; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008104 protein localization; GO:0008587 imaginal disc-derived wing margin morphogenesis; GO:0009611 response to wounding; GO:0009653 anatomical structure morphogenesis; GO:0009719 response to endogenous stimulus; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010720 positive regulation of cell development; GO:0010830 regulation of myotube differentiation; GO:0010831 positive regulation of myotube differentiation; GO:0010883 regulation of lipid storage; GO:0010884 positive regulation of lipid storage; GO:0010885 regulation of cholesterol storage; GO:0010886 positive regulation of cholesterol storage; GO:0010939 regulation of necrotic cell death; GO:0010940 positive regulation of necrotic cell death; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022607 cellular component assembly; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032456 endocytic recycling; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034381 plasma lipoprotein particle clearance; GO:0034383 low-density lipoprotein particle clearance; GO:0034613 cellular protein localization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042060 wound healing; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0042632 cholesterol homeostasis; GO:0042670 retinal cone cell differentiation; GO:0042886 amide transport; GO:0043010 camera-type eye development; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0044782 cilium organization; GO:0045184 establishment of protein localization; GO:0045466 R7 cell differentiation; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046530 photoreceptor cell differentiation; GO:0046907 intracellular transport; GO:0048052 R1/R6 cell differentiation; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048515 spermatid differentiation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048592 eye morphogenesis; GO:0048593 camera-type eye morphogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051147 regulation of muscle cell differentiation; GO:0051149 positive regulation of muscle cell differentiation; GO:0051153 regulation of striated muscle cell differentiation; GO:0051155 positive regulation of striated muscle cell differentiation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0055088 lipid homeostasis; GO:0055092 sterol homeostasis; GO:0060041 retina development in camera-type eye; GO:0060042 retina morphogenesis in camera-type eye; GO:0060142 regulation of syncytium formation by plasma membrane fusion; GO:0060143 positive regulation of syncytium formation by plasma membrane fusion; GO:0060219 camera-type eye photoreceptor cell differentiation; GO:0060271 cilium assembly; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0060988 lipid tube assembly; GO:0060990 lipid tube assembly involved in organelle fission; GO:0061512 protein localization to cilium; GO:0065003 protein-containing complex assembly; GO:0065005 protein-lipid complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070848 response to growth factor; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071310 cellular response to organic substance; GO:0071363 cellular response to growth factor stimulus; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071825 protein-lipid complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090596 sensory organ morphogenesis; GO:0097006 regulation of plasma lipoprotein particle levels; GO:0098657 import into cell; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:1901739 regulation of myoblast fusion; GO:1901741 positive regulation of myoblast fusion; GO:1904950 negative regulation of establishment of protein localization; GO:1905952 regulation of lipid localization; GO:1905954 positive regulation of lipid localization; GO:1990089 response to nerve growth factor; GO:1990090 cellular response to nerve growth factor stimulus; GO:1990255 subsynaptic reticulum organization; GO:2000026 regulation of multicellular organismal development; GO:2001135 regulation of endocytic recycling; GO:2001137 positive regulation of endocytic recycling;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005811 lipid droplet; GO:0005886 plasma membrane; GO:0005929 cilium; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0020016 ciliary pocket; GO:0020018 ciliary pocket membrane; GO:0030139 endocytic vesicle; GO:0030424 axon; GO:0031090 organelle membrane; GO:0031094 platelet dense tubular network; GO:0031095 platelet dense tubular network membrane; GO:0031253 cell projection membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031982 vesicle; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043195 terminal bouton; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0055037 recycling endosome; GO:0055038 recycling endosome membrane; GO:0060170 ciliary membrane; GO:0061174 type I terminal bouton; GO:0071212 subsynaptic reticulum; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098793 presynapse; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0051020 GTPase binding;","PF00350; PF18150","PF00350 Dynamin family; PF18150 Domain of unknown function (DUF5600)","TU","KOG1954","Endocytosis/signaling protein EHD1","WP481 INSULIN SIGNALING","http://www.wikipathways.org/instance/WP481_r120562",null,"R-HSA-109582 Hemostasis;R-HSA-983231 Factors involved in megakaryocyte development and platelet production","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-983231","COMPLEMENT;TNFA SIGNALING VIA NFKB","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_TNFA_SIGNALING_VIA_NFKB"]
["Q9H668","CST complex subunit STN1 OS=Homo sapiens OX=9606 GN=STN1 PE=1 SV=2","STN1",0.939291903,0.780729386,"nochange",4443.53,2976.62,2816.87,2959.82,3958.95,2696.78,1.342958619,0.899617531,0.851336628,0.894540102,1.196505037,0.815042083,"extracellular","K23312",null,null,"GO:0000723 telomere maintenance; GO:0001944 vasculature development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006275 regulation of DNA replication; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010639 negative regulation of organelle organization; GO:0010833 telomere maintenance via telomere lengthening; GO:0016043 cellular component organization; GO:0016233 telomere capping; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032200 telomere organization; GO:0032204 regulation of telomere maintenance; GO:0032205 negative regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032211 negative regulation of telomere maintenance via telomerase; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042592 homeostatic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0045740 positive regulation of DNA replication; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051276 chromosome organization; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904357 negative regulation of telomere maintenance via telomere lengthening; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000279 negative regulation of DNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000228 nuclear chromosome; GO:0000781 chromosome"," telomeric region; GO:0000782 telomere cap complex; GO:0000783 nuclear telomere cap complex; GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005856 cytoskeleton; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0032993 protein-DNA complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045111 intermediate filament cytoskeleton; GO:0070013 intracellular organelle lumen; GO:0098687 chromosomal region; GO:1990879 CST complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003697 single-stranded DNA binding; GO:0005488 binding; GO:0042162 telomeric DNA binding; GO:0043047 single-stranded telomeric DNA binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0098847 sequence-specific single stranded DNA binding; GO:1901363 heterocyclic compound binding;","PF01336; PF09170","PF01336 OB-fold nucleic acid binding domain; PF09170 CST"," complex subunit STN1"," C terminal","L","KOG3108","Single-stranded DNA-binding replication protein A (RPA)"," medium (30 kD) subunit","WP3624 LUNG FIBROSIS","http://www.wikipathways.org/instance/WP3624_r118417","Transcription factor","R-HSA-157579 Telomere Maintenance;R-HSA-1640170 Cell Cycle;R-HSA-174411 Polymerase switching on the C-strand of the telomere;R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis;R-HSA-174430 Telomere C-strand synthesis initiation;R-HSA-180786 Extension of Telomeres;R-HSA-73886 Chromosome Maintenance","https://reactome.org/PathwayBrowser/#/R-HSA-157579;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-174411;https://reactome.org/PathwayBrowser/#/R-HSA-174417;https://reactome.org/PathwayBrowser/#/R-HSA-174430;https://reactome.org/PathwayBrowser/#/R-HSA-180786;https://reactome.org/PathwayBrowser/#/R-HSA-73886"]
["Q9H6Q4","Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1","CIAO3",0.572395811,0.00032419,"down",9136.41,9126.41,9746.19,5782.26,5267.38,4982.6,1.244707178,1.243344819,1.327781114,0.787751483,0.717606335,0.678809071,"cytoplasm","nucleus",{"$nulls":3},"GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001666 response to hypoxia; GO:0001944 vasculature development; GO:0002040 sprouting angiogenesis; GO:0002244 hematopoietic progenitor cell differentiation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006790 sulfur compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0016043 cellular component organization; GO:0016226 iron-sulfur cluster assembly; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0031163 metallo-sulfur cluster assembly; GO:0032364 oxygen homeostasis; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033483 gas homeostasis; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036293 response to decreased oxygen levels; GO:0042592 homeostatic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048534 hematopoietic or lymphoid organ development; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070482 response to oxygen levels; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0032991 protein-containing complex; GO:0097361 CIA complex;","GO:0003824 catalytic activity; GO:0003954 NADH dehydrogenase activity; GO:0005488 binding; GO:0016491 oxidoreductase activity; GO:0016651 oxidoreductase activity"," acting on NAD(P)H; GO:0051536 iron-sulfur cluster binding; GO:0051540 metal cluster binding;","PF02906; PF02256","PF02906 Iron only hydrogenase large subunit"," C-terminal domain; PF02256 Iron hydrogenase small subunit","Y","KOG2439","Nuclear architecture related protein",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-2564830 Cytosolic iron-sulfur cluster assembly","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-2564830"]
["Q9H6U6","BCAS3 microtubule associated cell migration factor OS=Homo sapiens OX=9606 GN=BCAS3 PE=1 SV=3","BCAS3",1.235346405,0.001633365,"up",5254.24,5244.66,5093.69,6570.24,6599.92,6092.09,0.904478116,0.90282899,0.876840634,1.131017672,1.136126862,1.048707726,"nucleus","K24550",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0001952 regulation of cell-matrix adhesion; GO:0001953 negative regulation of cell-matrix adhesion; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006810 transport; GO:0006897 endocytosis; GO:0006907 pinocytosis; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007030 Golgi organization; GO:0007162 negative regulation of cell adhesion; GO:0007275 multicellular organism development; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010256 endomembrane system organization; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010594 regulation of endothelial cell migration; GO:0010595 positive regulation of endothelial cell migration; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010632 regulation of epithelial cell migration; GO:0010634 positive regulation of epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0010810 regulation of cell-substrate adhesion; GO:0010812 negative regulation of cell-substrate adhesion; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0031023 microtubule organizing center organization; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031667 response to nutrient levels; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032878 regulation of establishment or maintenance of cell polarity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0034260 negative regulation of GTPase activity; GO:0035148 tube formation; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042221 response to chemical; GO:0042594 response to starvation; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043547 positive regulation of GTPase activity; GO:0043627 response to estrogen; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044351 macropinocytosis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051716 cellular response to stimulus; GO:0051893 regulation of focal adhesion assembly; GO:0051895 negative regulation of focal adhesion assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060491 regulation of cell projection assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070887 cellular response to chemical stimulus; GO:0071391 cellular response to estrogen stimulus; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090109 regulation of cell-substrate junction assembly; GO:0090316 positive regulation of intracellular protein transport; GO:0090630 activation of GTPase activity; GO:0098657 import into cell; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901888 regulation of cell junction assembly; GO:1901889 negative regulation of cell junction assembly; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903391 regulation of adherens junction organization; GO:1903392 negative regulation of adherens junction organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903829 positive regulation of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000114 regulation of establishment of cell polarity; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility; GO:2000249 regulation of actin cytoskeleton reorganization; GO:2000251 positive regulation of actin cytoskeleton reorganization; GO:2001141 regulation of RNA biosynthetic process;","GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005881 cytoplasmic microtubule; GO:0015630 microtubule cytoskeleton; GO:0031252 cell leading edge; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045111 intermediate filament cytoskeleton; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber;","GO:0003682 chromatin binding; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008047 enzyme activator activity; GO:0008092 cytoskeletal protein binding; GO:0008134 transcription factor binding; GO:0010698 acetyltransferase activator activity; GO:0015631 tubulin binding; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0035035 histone acetyltransferase binding; GO:0042393 histone binding; GO:0048487 beta-tubulin binding; GO:0051427 hormone receptor binding; GO:0098772 molecular function regulator;",null,null,"S","KOG4415","Uncharacterized conserved protein","WP2858 ECTODERM DIFFERENTIATION","http://www.wikipathways.org/instance/WP2858_r116763"]
["Q9H7Z6","Histone acetyltransferase KAT8 OS=Homo sapiens OX=9606 GN=KAT8 PE=1 SV=2","KAT8",1.109240039,0.135673182,"nochange",12562.3,10759.9,10900.6,13063.1,12917.5,11980.7,1.044188402,0.894371475,0.906066571,1.085815297,1.073712909,0.995845345,"cytoplasm","K11308",null,null,"GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006473 protein acetylation; GO:0006475 internal protein amino acid acetylation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007549 dosage compensation; GO:0008152 metabolic process; GO:0009047 dosage compensation by hyperactivation of X chromosome; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0010212 response to ionizing radiation; GO:0010468 regulation of gene expression; GO:0010506 regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016573 histone acetylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0018393 internal peptidyl-lysine acetylation; GO:0018394 peptidyl-lysine acetylation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030330 DNA damage response"," signal transduction by p53 class mediator; GO:0031056 regulation of histone modification; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031399 regulation of protein modification process; GO:0031570 DNA integrity checkpoint signaling; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0035065 regulation of histone acetylation; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0042770 signal transduction in response to DNA damage; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043543 protein acylation; GO:0043967 histone H4 acetylation; GO:0043981 histone H4-K5 acetylation; GO:0043982 histone H4-K8 acetylation; GO:0043984 histone H4-K16 acetylation; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045786 negative regulation of cell cycle; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071214 cellular response to abiotic stimulus; GO:0071478 cellular response to radiation; GO:0071479 cellular response to ionizing radiation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072331 signal transduction by p53 class mediator; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090239 regulation of histone H4 acetylation; GO:0090304 nucleic acid metabolic process; GO:0104004 cellular response to environmental stimulus; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901983 regulation of protein acetylation; GO:1902275 regulation of chromatin organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000756 regulation of peptidyl-lysine acetylation; GO:2000873 regulation of histone H4 acetylation involved in response to DNA damage stimulus; GO:2001020 regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process;","GO:0000123 histone acetyltransferase complex; GO:0000228 nuclear chromosome; GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0000803 sex chromosome; GO:0000805 X chromosome; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005705 polytene chromosome interband; GO:0016456 X chromosome located dosage compensation complex"," transcription activating; GO:0031248 protein acetyltransferase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0035097 histone methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044545 NSL complex; GO:0044665 MLL1/2 complex; GO:0046536 dosage compensation complex; GO:0070013 intracellular organelle lumen; GO:0071339 MLL1 complex; GO:0072487 MSL complex; GO:0098687 chromosomal region; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1902562 H4 histone acetyltransferase complex; GO:1990234 transferase complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003682 chromatin binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003824 catalytic activity; GO:0004402 histone acetyltransferase activity; GO:0004468 lysine N-acetyltransferase activity"," acting on acetyl phosphate as donor; GO:0005488 binding; GO:0005515 protein binding; GO:0008080 N-acetyltransferase activity; GO:0008134 transcription factor binding; GO:0010485 H4 histone acetyltransferase activity; GO:0016407 acetyltransferase activity; GO:0016410 N-acyltransferase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups; GO:0019899 enzyme binding; GO:0034212 peptide N-acetyltransferase activity; GO:0035064 methylated histone binding; GO:0042393 histone binding; GO:0046972 histone acetyltransferase activity (H4-K16 specific); GO:0061733 peptide-lysine-N-acetyltransferase activity; GO:0097159 organic cyclic compound binding; GO:0140030 modification-dependent protein binding; GO:0140034 methylation-dependent protein binding; GO:1901363 heterocyclic compound binding;","PF17772","PF17772 MYST family zinc finger domain","B","KOG2747","Histone acetyltransferase (MYST family)",null,null,"Transcription factor","R-HSA-3214847 HATs acetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214847;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["Q9H8Y5","Ankyrin repeat and zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1","ANKZF1",0.664913392,0.000705422,"down",12828.7,13955.8,12218.7,8397.12,8582.64,8953.99,1.18533747,1.289478486,1.128975106,0.775871364,0.793012915,0.827324659,"nucleus","K26089",null,null,"GO:0000302 response to reactive oxygen species; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006515 protein quality control for misfolded or incompletely synthesized proteins; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009636 response to toxic substance; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010243 response to organonitrogen compound; GO:0010498 proteasomal protein catabolic process; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0030433 ubiquitin-dependent ERAD pathway; GO:0033554 cellular response to stress; GO:0034599 cellular response to oxidative stress; GO:0034614 cellular response to reactive oxygen species; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036503 ERAD pathway; GO:0042221 response to chemical; GO:0042542 response to hydrogen peroxide; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043632 modification-dependent macromolecule catabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0046677 response to antibiotic; GO:0050896 response to stimulus; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051716 cellular response to stimulus; GO:0051788 response to misfolded protein; GO:0070301 cellular response to hydrogen peroxide; GO:0070887 cellular response to chemical stimulus; GO:0071218 cellular response to misfolded protein; GO:0071236 cellular response to antibiotic; GO:0071310 cellular response to organic substance; GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system; GO:0071704 organic substance metabolic process; GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process; GO:0097237 cellular response to toxic substance; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0016020 membrane; GO:0019867 outer membrane; GO:0030425 dendrite; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097447 dendritic tree; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098799 outer mitochondrial membrane protein complex; GO:0120025 plasma membrane bounded cell projection;",null,"PF18826; PF18716","PF18826 Bacteroidetes VLRF1 release factor; PF18716 Vms1-associating treble clef domain","R","KOG2505","Ankyrin repeat protein",{"$nulls":5},"GLYCOLYSIS;HYPOXIA","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_GLYCOLYSIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HYPOXIA"]
["Q9H981","Actin-related protein 8 OS=Homo sapiens OX=9606 GN=ACTR8 PE=1 SV=2","ACTR8",1.357925862,0.090730996,"nochange",5621.69,4583.97,7218.06,8381.95,8298.98,6979.19,0.821007481,0.669455922,1.054145864,1.224123646,1.212006473,1.019260614,"cytoplasm","nucleus","K11673",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016579 protein deubiquitination; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000228 nuclear chromosome; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0031011 Ino80 complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0033202 DNA helicase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070603 SWI/SNF superfamily-type complex; GO:0097346 INO80-type complex; GO:1902494 catalytic complex; GO:1904949 ATPase complex;",{"$nulls":3},"Z","KOG0797","Actin-related protein",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5688426 Deubiquitination;R-HSA-5689603 UCH proteinases;R-HSA-5696394 DNA Damage Recognition in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-597592 Post-translational protein modification;R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5688426;https://reactome.org/PathwayBrowser/#/R-HSA-5689603;https://reactome.org/PathwayBrowser/#/R-HSA-5696394;https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-5696399;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-73894"]
["Q9H9Q2","COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1","COPS7B",1.154293717,0.193138634,"nochange",17680.1,20422.2,24733.7,24337.5,24521.4,23672.3,0.783650692,0.905191213,1.096293637,1.078732514,1.086883676,1.049248267,"cytoplasm","K12180",null,null,"GO:0000003 reproduction; GO:0000338 protein deneddylation; GO:0000715 nucleotide-excision repair"," DNA damage recognition; GO:0002009 morphogenesis of an epithelium; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006283 transcription-coupled nucleotide-excision repair; GO:0006289 nucleotide-excision repair; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007282 cystoblast division; GO:0007283 spermatogenesis; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0008152 metabolic process; GO:0008283 cell population proliferation; GO:0008356 asymmetric cell division; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016333 morphogenesis of follicular epithelium; GO:0019538 protein metabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0030718 germ-line stem cell population maintenance; GO:0030727 germarium-derived female germ-line cyst formation; GO:0031647 regulation of protein stability; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036099 female germ-line stem cell population maintenance; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0046483 heterocycle metabolic process; GO:0048134 germ-line cyst formation; GO:0048135 female germ-line cyst formation; GO:0048138 germ-line cyst encapsulation; GO:0048140 male germ-line cyst encapsulation; GO:0048142 germarium-derived cystoblast division; GO:0048232 male gamete generation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050821 protein stabilization; GO:0050896 response to stimulus; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051716 cellular response to stimulus; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0008180 COP9 signalosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0005488 binding; GO:0005515 protein binding;","PF01399; PF18392","PF01399 PCI domain; PF18392 COP9 signalosome complex subunit 7a helix I domain","OT","KOG3250","COP9 signalosome"," subunit CSN7","WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP4352_r102218",null,"R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-5653656 Vesicle-mediated transport;R-HSA-5696394 DNA Damage Recognition in GG-NER;R-HSA-5696398 Nucleotide Excision Repair;R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER);R-HSA-597592 Post-translational protein modification;R-HSA-6781823 Formation of TC-NER Pre-Incision Complex;R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER);R-HSA-73894 DNA Repair;R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis;R-HSA-8856828 Clathrin-mediated endocytosis;R-HSA-8951664 Neddylation","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-5696394;https://reactome.org/PathwayBrowser/#/R-HSA-5696398;https://reactome.org/PathwayBrowser/#/R-HSA-5696399;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6781823;https://reactome.org/PathwayBrowser/#/R-HSA-6781827;https://reactome.org/PathwayBrowser/#/R-HSA-73894;https://reactome.org/PathwayBrowser/#/R-HSA-8856825;https://reactome.org/PathwayBrowser/#/R-HSA-8856828;https://reactome.org/PathwayBrowser/#/R-HSA-8951664"]
["Q9HAB8","Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2","PPCS",0.998987135,0.980285318,"nochange",48403.4,43191.7,40604.2,42662.3,44757,44646.1,1.098975383,0.980646299,0.921898384,0.968626532,1.016185665,1.013667735,"cytoplasm","K01922","PPCS; phosphopantothenate---cysteine ligase (ATP) [EC:6.3.2.51]","hsa00770 Pantothenate and CoA biosynthesis; hsa01240 Biosynthesis of cofactors; hsa01100 Metabolic pathways","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001667 ameboidal-type cell migration; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002165 instar larval or pupal development; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007297 ovarian follicle cell migration; GO:0007300 ovarian nurse cell to oocyte transport; GO:0007303 cytoplasmic transport"," nurse cell to oocyte; GO:0007304 chorion-containing eggshell formation; GO:0007306 eggshell chorion assembly; GO:0007423 sensory organ development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0010927 cellular component assembly involved in morphogenesis; GO:0015936 coenzyme A metabolic process; GO:0015937 coenzyme A biosynthetic process; GO:0016043 cellular component organization; GO:0016333 morphogenesis of follicular epithelium; GO:0016477 cell migration; GO:0016482 cytosolic transport; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030154 cell differentiation; GO:0030703 eggshell formation; GO:0030707 ovarian follicle cell development; GO:0030708 germarium-derived female germ-line cyst encapsulation; GO:0030713 ovarian follicle cell stalk formation; GO:0030855 epithelial cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0040011 locomotion; GO:0042592 homeostatic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046843 dorsal appendage formation; GO:0046907 intracellular transport; GO:0048138 germ-line cyst encapsulation; GO:0048139 female germ-line cyst encapsulation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0055081 anion homeostasis; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0055088 lipid homeostasis; GO:0055090 acylglycerol homeostasis; GO:0055091 phospholipid homeostasis; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070328 triglyceride homeostasis; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090407 organophosphate biosynthetic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004632 phosphopantothenate--cysteine ligase activity; GO:0016874 ligase activity; GO:0016879 ligase activity"," forming carbon-nitrogen bonds; GO:0016881 acid-amino acid ligase activity;",null,null,"R","KOG2728","Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-196783 Coenzyme A biosynthesis;R-HSA-196849 Metabolism of water-soluble vitamins and cofactors;R-HSA-196854 Metabolism of vitamins and cofactors;R-HSA-199220 Vitamin B5 (pantothenate) metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-196783;https://reactome.org/PathwayBrowser/#/R-HSA-196849;https://reactome.org/PathwayBrowser/#/R-HSA-196854;https://reactome.org/PathwayBrowser/#/R-HSA-199220"]
["Q9HB71","Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2","CACYBP",1.057159782,0.25240513,"nochange",131868,141806,151730,153316,146338,150066,0.904109589,0.972246219,1.040286862,1.05116075,1.003318387,1.028878193,"nucleus","K04507","CACYBP; calcyclin binding protein","hsa04310 Wnt signaling pathway","GO:0006275 regulation of DNA replication; GO:0007275 multicellular organism development; GO:0007507 heart development; GO:0007568 aging; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010035 response to inorganic substance; GO:0010038 response to metal ion; GO:0010243 response to organonitrogen compound; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010941 regulation of cell death; GO:0014706 striated muscle tissue development; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034097 response to cytokine; GO:0035051 cardiocyte differentiation; GO:0042221 response to chemical; GO:0042692 muscle cell differentiation; GO:0043434 response to peptide hormone; GO:0045740 positive regulation of DNA replication; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048738 cardiac muscle tissue development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051146 striated muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051592 response to calcium ion; GO:0051716 cellular response to stimulus; GO:0055007 cardiac muscle cell differentiation; GO:0060255 regulation of macromolecule metabolic process; GO:0060416 response to growth hormone; GO:0060537 muscle tissue development; GO:0060548 negative regulation of cell death; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071241 cellular response to inorganic substance; GO:0071248 cellular response to metal ion; GO:0071277 cellular response to calcium ion; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:1901652 response to peptide; GO:1901698 response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005641 nuclear envelope lumen; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0019005 SCF ubiquitin ligase complex; GO:0030877 beta-catenin destruction complex; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044297 cell body; GO:0070013 intracellular organelle lumen; GO:0120025 plasma membrane bounded cell projection; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031625 ubiquitin protein ligase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0044389 ubiquitin-like protein ligase binding; GO:0046983 protein dimerization activity;","PF09032; PF04969; PF05002","PF09032 Siah interacting protein"," N terminal ; PF04969 CS domain; PF05002 SGS domain ","T","KOG3260","Calcyclin-binding protein CacyBP","WP2363 GASTRIC CANCER NETWORK 2","http://www.wikipathways.org/instance/WP2363_r117737",{"$nulls":3},"MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["Q9HC21","Mitochondrial thiamine pyrophosphate carrier OS=Homo sapiens OX=9606 GN=SLC25A19 PE=1 SV=1","SLC25A19",1.007281338,0.917548363,"nochange",11550.7,12079.4,11253.6,11197.9,11129.7,12810.1,0.989757417,1.03506071,0.964299486,0.959526659,0.953682731,1.097672997,"cytoplasm","K15108",null,null,"GO:0006725 cellular aromatic compound metabolic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006820 anion transport; GO:0006839 mitochondrial transport; GO:0006855 xenobiotic transmembrane transport; GO:0006862 nucleotide transport; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0015695 organic cation transport; GO:0015711 organic anion transport; GO:0015748 organophosphate ester transport; GO:0015931 nucleobase-containing compound transport; GO:0030302 deoxynucleotide transport; GO:0030974 thiamine pyrophosphate transmembrane transport; GO:0034220 ion transmembrane transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0035461 vitamin transmembrane transport; GO:0042221 response to chemical; GO:0042723 thiamine-containing compound metabolic process; GO:0044237 cellular metabolic process; GO:0044281 small molecule metabolic process; GO:0045117 azole transmembrane transport; GO:0046483 heterocycle metabolic process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051180 vitamin transport; GO:0051234 establishment of localization; GO:0055085 transmembrane transport; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071934 thiamine transmembrane transport; GO:0072348 sulfur compound transport; GO:0072527 pyrimidine-containing compound metabolic process; GO:0072531 pyrimidine-containing compound transmembrane transport; GO:0098655 cation transmembrane transport; GO:0098656 anion transmembrane transport; GO:1901264 carbohydrate derivative transport; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901679 nucleotide transmembrane transport; GO:1990542 mitochondrial transmembrane transport; GO:1990545 mitochondrial thiamine pyrophosphate transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031304 intrinsic component of mitochondrial inner membrane; GO:0031305 integral component of mitochondrial inner membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098573 intrinsic component of mitochondrial membrane;","GO:0005215 transporter activity; GO:0008324 cation transmembrane transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015101 organic cation transmembrane transporter activity; GO:0015215 nucleotide transmembrane transporter activity; GO:0015234 thiamine transmembrane transporter activity; GO:0015291 secondary active transmembrane transporter activity; GO:0015297 antiporter activity; GO:0015605 organophosphate ester transmembrane transporter activity; GO:0015932 nucleobase-containing compound transmembrane transporter activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0030233 deoxynucleotide transmembrane transporter activity; GO:0090422 thiamine pyrophosphate transmembrane transporter activity; GO:0090482 vitamin transmembrane transporter activity; GO:1901474 azole transmembrane transporter activity; GO:1901682 sulfur compound transmembrane transporter activity;",null,null,"C","KOG0752","Mitochondrial solute carrier protein","WP4297 THIAMINE METABOLIC PATHWAYS","http://www.wikipathways.org/instance/WP4297_r120409",null,"R-HSA-1430728 Metabolism;R-HSA-196819 Vitamin B1 (thiamin) metabolism;R-HSA-196849 Metabolism of water-soluble vitamins and cofactors;R-HSA-196854 Metabolism of vitamins and cofactors","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-196819;https://reactome.org/PathwayBrowser/#/R-HSA-196849;https://reactome.org/PathwayBrowser/#/R-HSA-196854","PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["Q9HCE5","N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2","METTL14",0.654083433,0.057869917,"nochange",5681.65,3850.19,6077.82,3617.61,2995.11,3597.3,1.320306836,0.894710546,1.41236917,0.840663401,0.696006302,0.835943745,"cytoplasm","K23960",null,null,"GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000398 mRNA splicing"," via spliceosome; GO:0001510 RNA methylation; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006417 regulation of translation; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007530 sex determination; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009451 RNA modification; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010001 glial cell differentiation; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016556 mRNA modification; GO:0017148 negative regulation of translation; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0021861 forebrain radial glial cell differentiation; GO:0021872 forebrain generation of neurons; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0030154 cell differentiation; GO:0030237 female sex determination; GO:0030900 forebrain development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032259 methylation; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0034248 regulation of cellular amide metabolic process; GO:0034249 negative regulation of cellular amide metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042063 gliogenesis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0043484 regulation of RNA splicing; GO:0043487 regulation of RNA stability; GO:0043488 regulation of mRNA stability; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044703 multi-organism reproductive process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0048232 male gamete generation; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050684 regulation of mRNA processing; GO:0050779 RNA destabilization; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060019 radial glial cell differentiation; GO:0060255 regulation of macromolecule metabolic process; GO:0060322 head development; GO:0061013 regulation of mRNA catabolic process; GO:0061014 positive regulation of mRNA catabolic process; GO:0061157 mRNA destabilization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0080009 mRNA methylation; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0098727 maintenance of cell number; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process; GO:1903311 regulation of mRNA metabolic process; GO:1903313 positive regulation of mRNA metabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034708 methyltransferase complex; GO:0036396 RNA N6-methyladenosine methyltransferase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045293 mRNA editing complex; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0001734 mRNA (N6-adenosine)-methyltransferase activity; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0008168 methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008174 mRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0097159 organic cyclic compound binding; GO:0140098 catalytic activity"," acting on RNA; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG2097","Predicted N6-adenine methylase involved in transcription regulation",null,null,"Transcription factor","R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9HD20","Endoplasmic reticulum transmembrane helix translocase OS=Homo sapiens OX=9606 GN=ATP13A1 PE=1 SV=2","ATP13A1",1.154362428,0.029224528,"nochange",18536.3,19460.1,17817.7,22798.7,21408.1,20222.9,0.924935839,0.971032186,0.889078688,1.137623728,1.068234703,1.009094856,"plasma membrane","K14950",null,null,"GO:0000041 transition metal ion transport; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006816 calcium ion transport; GO:0006828 manganese ion transport; GO:0006873 cellular ion homeostasis; GO:0006874 cellular calcium ion homeostasis; GO:0006875 cellular metal ion homeostasis; GO:0009987 cellular process; GO:0019725 cellular homeostasis; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0034220 ion transmembrane transport; GO:0042592 homeostatic process; GO:0048878 chemical homeostasis; GO:0050801 ion homeostasis; GO:0051179 localization; GO:0051234 establishment of localization; GO:0055065 metal ion homeostasis; GO:0055074 calcium ion homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070588 calcium ion transmembrane transport; GO:0071421 manganese ion transmembrane transport; GO:0072503 cellular divalent inorganic cation homeostasis; GO:0072507 divalent inorganic cation homeostasis; GO:0098655 cation transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098771 inorganic ion homeostasis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0005384 manganese ion transmembrane transporter activity; GO:0005388 P-type calcium transporter activity; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015085 calcium ion transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015410 ABC-type manganese transporter activity; GO:0015662 P-type ion transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019829 ATPase-coupled cation transmembrane transporter activity; GO:0022804 active transmembrane transporter activity; GO:0022853 active ion transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0042625 ATPase-coupled ion transmembrane transporter activity; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0046873 metal ion transmembrane transporter activity; GO:0046915 transition metal ion transmembrane transporter activity;","PF00702","PF00702 haloacid dehalogenase-like hydrolase","P","KOG0209","P-type ATPase",{"$nulls":3},"R-HSA-382551 Transport of small molecules;R-HSA-936837 Ion transport by P-type ATPases;R-HSA-983712 Ion channel transport","https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-936837;https://reactome.org/PathwayBrowser/#/R-HSA-983712"]
["Q9HD34","LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1","LYRM4",1.042838852,0.456597791,"nochange",12734,11219.9,13145.6,13468.1,12565.1,12655.6,1.008123945,0.888255839,1.04070945,1.066241095,0.994752488,1.001917182,"mitochondria","K22069",null,null,"GO:0006790 sulfur compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016226 iron-sulfur cluster assembly; GO:0022607 cellular component assembly; GO:0031163 metallo-sulfur cluster assembly; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044281 small molecule metabolic process; GO:0071840 cellular component organization or biogenesis;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990221 L-cysteine desulfurase complex;",{"$nulls":3},"A","KOG3801","Uncharacterized conserved protein BCN92",{"$nulls":3},"R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis;R-HSA-1430728 Metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1362409;https://reactome.org/PathwayBrowser/#/R-HSA-1430728"]
["Q9NPA8","Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1","ENY2",1.481134808,0.006457388,"up",26689.8,21562,21832.3,34477.7,32758.2,36568.1,0.920930184,0.743995708,0.753322395,1.189651276,1.130320016,1.261780421,"cytoplasm","K11368",null,null,"GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006406 mRNA export from nucleus; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006611 protein export from nucleus; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006996 organelle organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010639 negative regulation of organelle organization; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010817 regulation of hormone levels; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016570 histone modification; GO:0016578 histone deubiquitination; GO:0016579 protein deubiquitination; GO:0016973 poly(A)+ mRNA export from nucleus; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031503 protein-containing complex localization; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0034613 cellular protein localization; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046676 negative regulation of insulin secretion; GO:0046883 regulation of hormone secretion; GO:0046888 negative regulation of hormone secretion; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050796 regulation of insulin secretion; GO:0051028 mRNA transport; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070201 regulation of establishment of protein localization; GO:0070646 protein modification by small protein removal; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0071166 ribonucleoprotein complex localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090276 regulation of peptide hormone secretion; GO:0090278 negative regulation of peptide hormone secretion; GO:1901564 organonitrogen compound metabolic process; GO:1902275 regulation of chromatin organization; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization; GO:1905268 negative regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization;","GO:0000123 histone acetyltransferase complex; GO:0000124 SAGA complex; GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005643 nuclear pore; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0012505 endomembrane system; GO:0031248 protein acetyltransferase complex; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0070390 transcription export complex 2; GO:0070461 SAGA-type complex; GO:0071819 DUBm complex; GO:1902493 acetyltransferase complex; GO:1902494 catalytic complex; GO:1905368 peptidase complex; GO:1990234 transferase complex;","GO:0001091 RNA polymerase II general transcription initiation factor binding; GO:0001094 TFIID-class transcription factor complex binding; GO:0001098 basal transcription machinery binding; GO:0001099 basal RNA polymerase II transcription machinery binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0019904 protein domain specific binding; GO:0030374 nuclear receptor coactivator activity; GO:0031490 chromatin DNA binding; GO:0043035 chromatin insulator sequence binding; GO:0070742 C2H2 zinc finger domain binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG4479","Transcription factor e(y)2",{"$nulls":3},"R-HSA-3214847 HATs acetylate histones;R-HSA-3247509 Chromatin modifying enzymes;R-HSA-4839726 Chromatin organization","https://reactome.org/PathwayBrowser/#/R-HSA-3214847;https://reactome.org/PathwayBrowser/#/R-HSA-3247509;https://reactome.org/PathwayBrowser/#/R-HSA-4839726"]
["Q9NPH3","Interleukin-1 receptor accessory protein OS=Homo sapiens OX=9606 GN=IL1RAP PE=1 SV=2","IL1RAP",0.861775094,0.105875732,"nochange",17026.3,18068.9,18047.9,16474.3,16136.4,13186.7,1.032517523,1.095743401,1.094469909,0.999042859,0.978551756,0.799674552,"peroxisome","K04723","IL1RAP; interleukin 1 receptor accessory protein","hsa04750 Inflammatory mediator regulation of TRP channels; hsa04060 Cytokine-cytokine receptor interaction; hsa04659 Th17 cell differentiation; hsa04010 MAPK signaling pathway","GO:0001816 cytokine production; GO:0001817 regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002376 immune system process; GO:0002790 peptide secretion; GO:0002791 regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0006355 regulation of transcription"," DNA-templated; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006952 defense response; GO:0006954 inflammatory response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009306 protein secretion; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010720 positive regulation of cell development; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032623 interleukin-2 production; GO:0032633 interleukin-4 production; GO:0032656 regulation of interleukin-13 production; GO:0032674 regulation of interleukin-5 production; GO:0032675 regulation of interleukin-6 production; GO:0032736 positive regulation of interleukin-13 production; GO:0032754 positive regulation of interleukin-5 production; GO:0032755 positive regulation of interleukin-6 production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032940 secretion by cell; GO:0033036 macromolecule localization; GO:0034097 response to cytokine; GO:0038172 interleukin-33-mediated signaling pathway; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050708 regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050803 regulation of synapse structure or activity; GO:0050807 regulation of synapse organization; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051094 positive regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0051963 regulation of synapse assembly; GO:0051965 positive regulation of synapse assembly; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070555 response to interleukin-1; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900006 positive regulation of dendrite development; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904951 positive regulation of establishment of protein localization; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0032991 protein-containing complex; GO:0071944 cell periphery;","GO:0002114 interleukin-33 receptor activity; GO:0004888 transmembrane signaling receptor activity; GO:0004896 cytokine receptor activity; GO:0004908 interleukin-1 receptor activity; GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005149 interleukin-1 receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0038023 signaling receptor activity; GO:0060089 molecular transducer activity; GO:0070851 growth factor receptor binding; GO:1990782 protein tyrosine kinase binding;","PF18452; PF13927","PF18452 Immunoglobulin domain; PF13927 Immunoglobulin domain",{"$nulls":3},"WP195 IL1 SIGNALING PATHWAY;WP2637 INTERLEUKIN1 IL1 STRUCTURAL PATHWAY;WP4496 SIGNAL TRANSDUCTION THROUGH IL1R","http://www.wikipathways.org/instance/WP195_r120702;http://www.wikipathways.org/instance/WP2637_r117962;http://www.wikipathways.org/instance/WP4496_r102693"]
["Q9NQ75","Cas scaffolding protein family member 4 OS=Homo sapiens OX=9606 GN=CASS4 PE=1 SV=2","CASS4",1.182100065,0.37995507,"nochange",2063.25,1719.61,1775.54,"NA",2574.61,1805.78,1.037978466,0.865100279,0.893237507,"NA",1.295233122,0.908450626,"cytoplasm","nucleus",{"$nulls":6},"PF14604; PF08824; PF12026","PF14604 Variant SH3 domain; PF08824 Serine rich protein interaction domain; PF12026 Crk-Associated Substrate C-terminal domain"]
["Q9NQG7","BLOC-3 complex member HPS4 OS=Homo sapiens OX=9606 GN=HPS4 PE=1 SV=2","HPS4",0.890711244,0.486379804,"nochange",3482.13,3624.83,2529.53,2392.46,2939.23,3251.64,1.146706169,1.19369895,0.833003839,0.787865083,0.967922844,1.070803114,"nucleus","K20194",null,null,"GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006605 protein targeting; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007033 vacuole organization; GO:0007040 lysosome organization; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0008104 protein localization; GO:0009611 response to wounding; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016441 posttranscriptional gene silencing; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030154 cell differentiation; GO:0030318 melanocyte differentiation; GO:0031047 gene silencing by RNA; GO:0031048 heterochromatin assembly by small RNA; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031647 regulation of protein stability; GO:0032438 melanosome organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033059 cellular pigmentation; GO:0034613 cellular protein localization; GO:0035194 post-transcriptional gene silencing by RNA; GO:0035195 gene silencing by miRNA; GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA; GO:0040029 regulation of gene expression"," epigenetic; GO:0042060 wound healing; GO:0042886 amide transport; GO:0043473 pigmentation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045184 establishment of protein localization; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046907 intracellular transport; GO:0048066 developmental pigmentation; GO:0048070 regulation of developmental pigmentation; GO:0048073 regulation of eye pigmentation; GO:0048075 positive regulation of eye pigmentation; GO:0048087 positive regulation of developmental pigmentation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048753 pigment granule organization; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050817 coagulation; GO:0050821 protein stabilization; GO:0050878 regulation of body fluid levels; GO:0050896 response to stimulus; GO:0050931 pigment cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060966 regulation of gene silencing by RNA; GO:0060967 negative regulation of gene silencing by RNA; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070727 cellular macromolecule localization; GO:0070922 small RNA loading onto RISC; GO:0070923 siRNA loading onto RISC involved in gene silencing by small RNA; GO:0070925 organelle assembly; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080171 lytic vacuole organization; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903232 melanosome assembly; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030141 secretory granule; GO:0031082 BLOC complex; GO:0031085 BLOC-3 complex; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031902 late endosome membrane; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042470 melanosome; GO:0042827 platelet dense granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048770 pigment granule; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098852 lytic vacuole membrane; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0051020 GTPase binding;","PF19031; PF19033","PF19031 First Longin domain of INTU"," CCZ1 and HPS4; PF19033 Intu longin-like domain 3",{"$nulls":6},"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs;R-HSA-9007101 Rab regulation of trafficking","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8876198;https://reactome.org/PathwayBrowser/#/R-HSA-9007101"]
["Q9NQZ2","Something about silencing protein 10 OS=Homo sapiens OX=9606 GN=UTP3 PE=1 SV=1","UTP3",0.938384391,0.596834236,"nochange",14561.9,11386,15570.8,12921.2,12805.2,13234.1,1.085639519,0.848865297,1.16085647,0.963319715,0.954671518,0.986647482,"nucleus","K14767",null,null,"GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030490 maturation of SSU-rRNA; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042274 ribosomal small subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0060322 head development; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0030684 preribosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032040 small-subunit processome; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;",null,"PF09368","PF09368 Sas10 C-terminal domain","B","KOG3118","Disrupter of silencing SAS10",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9NRK6","ATP-binding cassette sub-family B member 10"," mitochondrial OS=Homo sapiens OX=9606 GN=ABCB10 PE=1 SV=2","ABCB10",1.049019388,0.344769369,"nochange",20379.6,20184.6,21856,23390.4,21350,20739.6,0.956039162,0.946891404,1.025299413,1.097280536,1.001562155,0.972927329,"plasma membrane","K05657","ABCB10; ATP-binding cassette"," subfamily B (MDR/TAP)"," member 10","hsa02010 ABC transporters","GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006725 cellular aromatic compound metabolic process; GO:0006778 porphyrin-containing compound metabolic process; GO:0006779 porphyrin-containing compound biosynthetic process; GO:0006783 heme biosynthetic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0030150 protein import into mitochondrial matrix; GO:0033013 tetrapyrrole metabolic process; GO:0033014 tetrapyrrole biosynthetic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034514 mitochondrial unfolded protein response; GO:0034613 cellular protein localization; GO:0034620 cellular response to unfolded protein; GO:0034641 cellular nitrogen compound metabolic process; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0042168 heme metabolic process; GO:0042221 response to chemical; GO:0042440 pigment metabolic process; GO:0042886 amide transport; GO:0044237 cellular metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045184 establishment of protein localization; GO:0046148 pigment biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0065002 intracellular protein transmembrane transport; GO:0070585 protein localization to mitochondrion; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1990542 mitochondrial transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098573 intrinsic component of mitochondrial membrane;","GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0005488 binding; GO:0005515 protein binding; GO:0015399 primary active transmembrane transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity;","PF00005","PF00005 ABC transporter","U","KOG0058","Peptide exporter"," ABC superfamily",{"$nulls":3},"R-HSA-1369007 Mitochondrial ABC transporters;R-HSA-382551 Transport of small molecules;R-HSA-382556 ABC-family proteins mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-1369007;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-382556"]
["Q9NRN7","L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2","AASDHPPT",0.73343516,0.00368387,"down",22863.4,24796.9,22852,17056.6,18621.1,16038.5,1.122327444,1.217239842,1.121767836,0.837280994,0.914079777,0.787304107,"mitochondria","K06133","LYS5; 4'-phosphopantetheinyl transferase [EC:2.7.8.-]","hsa00770 Pantothenate and CoA biosynthesis; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006553 lysine metabolic process; GO:0006575 cellular modified amino acid metabolic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008652 cellular amino acid biosynthetic process; GO:0009058 biosynthetic process; GO:0009066 aspartate family amino acid metabolic process; GO:0009067 aspartate family amino acid biosynthetic process; GO:0009085 lysine biosynthetic process; GO:0009987 cellular process; GO:0015939 pantothenate metabolic process; GO:0016053 organic acid biosynthetic process; GO:0019752 carboxylic acid metabolic process; GO:0019878 lysine biosynthetic process via aminoadipic acid; GO:0032787 monocarboxylic acid metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901607 alpha-amino acid biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0000287 magnesium ion binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0008897 holo-[acyl-carrier-protein] synthase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016780 phosphotransferase activity"," for other substituted phosphate groups; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding;","PF01648","PF01648 4'-phosphopantetheinyl transferase superfamily","EH","KOG0945","Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-196849 Metabolism of water-soluble vitamins and cofactors;R-HSA-196854 Metabolism of vitamins and cofactors;R-HSA-199220 Vitamin B5 (pantothenate) metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-196849;https://reactome.org/PathwayBrowser/#/R-HSA-196854;https://reactome.org/PathwayBrowser/#/R-HSA-199220"]
["Q9NS39","Double-stranded RNA-specific editase B2 OS=Homo sapiens OX=9606 GN=ADARB2 PE=1 SV=1","ADARB2",1.092631414,0.355972314,"nochange",5459.58,7070.19,5601.66,6457.31,6264.17,7089.49,0.863347601,1.118040504,0.885815341,1.021123071,0.990580986,1.121092498,"nucleus","K13194",null,null,"GO:0000003 reproduction; GO:0001666 response to hypoxia; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006382 adenosine to inosine editing; GO:0006396 RNA processing; GO:0006469 negative regulation of protein kinase activity; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0007610 behavior; GO:0007617 mating behavior; GO:0007618 mating; GO:0007619 courtship behavior; GO:0007622 rhythmic behavior; GO:0007623 circadian rhythm; GO:0007626 locomotory behavior; GO:0008049 male courtship behavior; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0008340 determination of adult lifespan; GO:0008344 adult locomotory behavior; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009451 RNA modification; GO:0009628 response to abiotic stimulus; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010259 multicellular organism aging; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0016553 base conversion or substitution editing; GO:0016556 mRNA modification; GO:0019098 reproductive behavior; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0030534 adult behavior; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032103 positive regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0033673 negative regulation of kinase activity; GO:0034641 cellular nitrogen compound metabolic process; GO:0036293 response to decreased oxygen levels; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0040028 regulation of vulval development; GO:0042127 regulation of cell population proliferation; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042391 regulation of membrane potential; GO:0042752 regulation of circadian rhythm; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0043903 regulation of biological process involved in symbiotic interaction; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation; GO:0044703 multi-organism reproductive process; GO:0045069 regulation of viral genome replication; GO:0045070 positive regulation of viral genome replication; GO:0045475 locomotor rhythm; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046483 heterocycle metabolic process; GO:0048511 rhythmic process; GO:0048512 circadian behavior; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048524 positive regulation of viral process; GO:0048580 regulation of post-embryonic development; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050792 regulation of viral process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0050920 regulation of chemotaxis; GO:0050921 positive regulation of chemotaxis; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051726 regulation of cell cycle; GO:0060147 regulation of posttranscriptional gene silencing; GO:0060179 male mating behavior; GO:0060255 regulation of macromolecule metabolic process; GO:0060964 regulation of gene silencing by miRNA; GO:0060966 regulation of gene silencing by RNA; GO:0061062 regulation of nematode larval development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070482 response to oxygen levels; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903900 regulation of viral life cycle; GO:1903902 positive regulation of viral life cycle; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005840 ribosome; GO:0022626 cytosolic ribosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003725 double-stranded RNA binding; GO:0003726 double-stranded RNA adenosine deaminase activity; GO:0003727 single-stranded RNA binding; GO:0003729 mRNA binding; GO:0003824 catalytic activity; GO:0004000 adenosine deaminase activity; GO:0005488 binding; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016814 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in cyclic amidines; GO:0019239 deaminase activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00035","PF00035 Double-stranded RNA binding motif","A","KOG2777","tRNA-specific adenosine deaminase 1"]
["Q9NSI8","SAM domain-containing protein SAMSN-1 OS=Homo sapiens OX=9606 GN=SAMSN1 PE=1 SV=1","SAMSN1",0.761398699,0.005770952,"down",36199.1,37846.7,36697.1,25416,29198.6,29704.9,1.113462154,1.164141321,1.128780329,0.781780599,0.89813106,0.913704538,"nucleus","K23707",null,null,"GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002819 regulation of adaptive immune response; GO:0002820 negative regulation of adaptive immune response; GO:0009892 negative regulation of metabolic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0045936 negative regulation of phosphate metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050864 regulation of B cell activation; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050869 negative regulation of B cell activation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051250 negative regulation of lymphocyte activation; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031252 cell leading edge; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0120025 plasma membrane bounded cell projection;","GO:0001784 phosphotyrosine residue binding; GO:0005488 binding; GO:0005515 protein binding; GO:0045309 protein phosphorylated amino acid binding; GO:0051219 phosphoprotein binding;","PF07653; PF07647","PF07653 Variant SH3 domain; PF07647 SAM domain (Sterile alpha motif)","R","KOG4384","Uncharacterized SAM domain protein","WP3945 TYROBP CAUSAL NETWORK IN MICROGLIA","http://www.wikipathways.org/instance/WP3945_r116679"]
["Q9NTJ5","Phosphatidylinositol-3-phosphatase SAC1 OS=Homo sapiens OX=9606 GN=SACM1L PE=1 SV=2","SACM1L",0.997937396,0.893612022,"nochange",77520,77699.5,75120.4,75651.9,78001.1,76211.8,1.010680682,1.013020945,0.979395473,0.986324998,1.016953108,0.993624793,"plasma membrane","K21797","SAC1; phosphatidylinositol 4-phosphatase [EC:3.1.3.-]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0000226 microtubule cytoskeleton organization; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001700 embryonic development via the syncytial blastoderm; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007275 multicellular organism development; GO:0007391 dorsal closure; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0008037 cell recognition; GO:0008038 neuron recognition; GO:0008088 axo-dendritic transport; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0016198 axon choice point recognition; GO:0016199 axon midline choice point recognition; GO:0016311 dephosphorylation; GO:0016331 morphogenesis of embryonic epithelium; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030258 lipid modification; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031122 cytoplasmic microtubule organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042330 taxis; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046474 glycerophospholipid biosynthetic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046664 dorsal closure"," amnioserosa morphology change; GO:0046839 phospholipid dephosphorylation; GO:0046856 phosphatidylinositol dephosphorylation; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048598 embryonic morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060074 synapse maturation; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090407 organophosphate biosynthetic process; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0099111 microtubule-based transport; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0008328 ionotropic glutamate receptor complex; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031984 organelle subcompartment; GO:0032281 AMPA glutamate receptor complex; GO:0032991 protein-containing complex; GO:0034702 ion channel complex; GO:0034703 cation channel complex; GO:0036477 somatodendritic compartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043235 receptor complex; GO:0044297 cell body; GO:0071683 sensory dendrite; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098802 plasma membrane signaling receptor complex; GO:0098827 endoplasmic reticulum subcompartment; GO:0098878 neurotransmitter receptor complex; GO:0120025 plasma membrane bounded cell projection; GO:1902495 transmembrane transporter complex; GO:1990351 transporter complex;","GO:0003824 catalytic activity; GO:0004438 phosphatidylinositol-3-phosphatase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0034593 phosphatidylinositol bisphosphate phosphatase activity; GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity; GO:0052744 phosphatidylinositol monophosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity;",null,null,"I","KOG1889","Putative phosphoinositide phosphatase","WP4971 PHOSPHOINOSITIDES METABOLISM","http://www.wikipathways.org/instance/WP4971_r112223",null,"R-HSA-1430728 Metabolism;R-HSA-1483248 Synthesis of PIPs at the ER membrane;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660514 Synthesis of PIPs at the Golgi membrane;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483248;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660514;https://reactome.org/PathwayBrowser/#/R-HSA-556833"]
["Q9NUS5","AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1","AP5S1",0.595771807,0.016932146,"nochange",3430.53,4452.43,4055,2832.42,2337.32,1942.56,1.080467143,1.402321018,1.277147923,0.892088612,0.736153732,0.611821571,"mitochondria","K19024",null,null,"GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006302 double-strand break repair; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005768 endosome; GO:0005770 late endosome; GO:0005773 vacuole; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048475 coated membrane; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098796 membrane protein complex;"]
["Q9NVA2","Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3","SEPTIN11",1.096017588,0.095543694,"nochange",111157,125514,124492,127560,134924,133357,0.88102837,0.994821692,0.986721338,1.011038251,1.069405181,1.056985168,"nucleus","K16939","SEPT6_8_11; septin 6/8/11","hsa05100 Bacterial invasion of epithelial cells; hsa05131 Shigellosis","GO:0000003 reproduction; GO:0000278 mitotic cell cycle; GO:0000281 mitotic cytokinesis; GO:0000910 cytokinesis; GO:0003006 developmental process involved in reproduction; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007295 growth of a germarium-derived egg chamber; GO:0007349 cellularization; GO:0007444 imaginal disc development; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0035295 tube development; GO:0040007 growth; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051259 protein complex oligomerization; GO:0051291 protein heterooligomerization; GO:0051301 cell division; GO:0051726 regulation of cell cycle; GO:0060429 epithelium development; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:1903047 mitotic cell cycle process;","GO:0001725 stress fiber; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0005938 cell cortex; GO:0005940 septin ring; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030424 axon; GO:0030425 dendrite; GO:0030496 midbody; GO:0031105 septin complex; GO:0032153 cell division site; GO:0032154 cleavage furrow; GO:0032156 septin cytoskeleton; GO:0032432 actin filament bundle; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042641 actomyosin; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043197 dendritic spine; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044309 neuron spine; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0097517 contractile actin filament bundle; GO:0098590 plasma membrane region; GO:0098794 postsynapse; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017111 nucleoside-triphosphatase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity;","PF00735","PF00735 Septin","D","KOG3859","Septins (P-loop GTPases)","WP4657 22Q112 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4657_r120007"]
["Q9NVH6","Trimethyllysine dioxygenase"," mitochondrial OS=Homo sapiens OX=9606 GN=TMLHE PE=1 SV=1","TMLHE",0.770103985,0.078589949,"nochange",6494.57,6271.12,5969.65,4409.11,5935.54,4083.51,1.175009272,1.134582297,1.080039803,0.797704102,1.07386856,0.738795965,"mitochondria","K00474","TMLHE; trimethyllysine dioxygenase [EC:1.14.11.8]","hsa00310 Lysine degradation; hsa01100 Metabolic pathways","GO:0006575 cellular modified amino acid metabolic process; GO:0006577 amino-acid betaine metabolic process; GO:0006578 amino-acid betaine biosynthetic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009437 carnitine metabolic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0019222 regulation of metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042398 cellular modified amino acid biosynthetic process; GO:0043086 negative regulation of catalytic activity; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045329 carnitine biosynthetic process; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0051341 regulation of oxidoreductase activity; GO:0051354 negative regulation of oxidoreductase activity; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0097164 ammonium ion metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0016491 oxidoreductase activity; GO:0016701 oxidoreductase activity"," acting on single donors with incorporation of molecular oxygen; GO:0016702 oxidoreductase activity"," acting on single donors with incorporation of molecular oxygen"," incorporation of two atoms of oxygen; GO:0016705 oxidoreductase activity"," acting on paired donors"," with incorporation or reduction of molecular oxygen; GO:0016706 2-oxoglutarate-dependent dioxygenase activity; GO:0050353 trimethyllysine dioxygenase activity; GO:0051213 dioxygenase activity;","PF06155; PF02668","PF06155 Gamma-butyrobetaine hydroxylase-like"," N-terminal; PF02668 Taurine catabolism dioxygenase TauD"," TfdA family","I","KOG3889","Predicted gamma-butyrobetaine","2-oxoglutarate dioxygenase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-71262 Carnitine synthesis;R-HSA-71291 Metabolism of amino acids and derivatives","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-71262;https://reactome.org/PathwayBrowser/#/R-HSA-71291"]
["Q9NVN8","Guanine nucleotide-binding protein-like 3-like protein OS=Homo sapiens OX=9606 GN=GNL3L PE=1 SV=1","GNL3L",1.374233982,{"v":1.3606E-5,"d":"1.36E-05"},"up",12543.8,12674.1,12167,17071.3,17170.2,17134.1,0.847931231,0.856739203,0.822460441,1.153979529,1.160664935,1.158224661,"nucleus","K14538","NUG1; nuclear GTP-binding protein","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0002119 nematode larval development; GO:0002164 larval development; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0016043 cellular component organization; GO:0017145 stem cell division; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019827 stem cell population maintenance; GO:0019953 sexual reproduction; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032091 negative regulation of protein binding; GO:0032092 positive regulation of protein binding; GO:0032204 regulation of telomere maintenance; GO:0032205 negative regulation of telomere maintenance; GO:0032206 positive regulation of telomere maintenance; GO:0032210 regulation of telomere maintenance via telomerase; GO:0032211 negative regulation of telomere maintenance via telomerase; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033233 regulation of protein sumoylation; GO:0033234 negative regulation of protein sumoylation; GO:0033235 positive regulation of protein sumoylation; GO:0040008 regulation of growth; GO:0040014 regulation of multicellular organism growth; GO:0042127 regulation of cell population proliferation; GO:0042254 ribosome biogenesis; GO:0042273 ribosomal large subunit biogenesis; GO:0043393 regulation of protein binding; GO:0043496 regulation of protein homodimerization activity; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044703 multi-organism reproductive process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048638 regulation of developmental growth; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051054 positive regulation of DNA metabolic process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051225 spindle assembly; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051301 cell division; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090073 positive regulation of protein homodimerization activity; GO:0090307 mitotic spindle assembly; GO:0098727 maintenance of cell number; GO:0140014 mitotic nuclear division; GO:1902680 positive regulation of RNA biosynthetic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1902893 regulation of miRNA transcription; GO:1902895 positive regulation of miRNA transcription; GO:1903047 mitotic cell cycle process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1903829 positive regulation of protein localization; GO:1904356 regulation of telomere maintenance via telomere lengthening; GO:1904357 negative regulation of telomere maintenance via telomere lengthening; GO:1904814 regulation of protein localization to chromosome"," telomeric region; GO:1904816 positive regulation of protein localization to chromosome"," telomeric region; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000278 regulation of DNA biosynthetic process; GO:2000279 negative regulation of DNA biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001251 negative regulation of chromosome organization; GO:2001252 positive regulation of chromosome organization;","GO:0001652 granular component; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005697 telomerase holoenzyme complex; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005488 binding; GO:0005525 GTP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0048027 mRNA 5'-UTR binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG2484","GTPase"]
["Q9NW64","Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1","RBM22",1.489292975,{"v":5.0591e-05,"d":"5.06E-05"},"up",16718.8,17411.4,17662.9,26028.5,25000.5,26106.1,0.77805166,0.810283553,0.821987742,1.211302105,1.163461524,1.214913417,"cytoplasm","K12872","RBM22; pre-mRNA-splicing factor RBM22/SLT11","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006606 protein import into nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0007275 multicellular organism development; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0017038 protein import; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0032386 regulation of intracellular transport; GO:0032388 positive regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033036 macromolecule localization; GO:0033120 positive regulation of RNA splicing; GO:0033157 regulation of intracellular protein transport; GO:0033365 protein localization to organelle; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042306 regulation of protein import into nucleus; GO:0042307 positive regulation of protein import into nucleus; GO:0042886 amide transport; GO:0043009 chordate embryonic development; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045184 establishment of protein localization; GO:0045292 mRNA cis splicing"," via spliceosome; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046824 positive regulation of nucleocytoplasmic transport; GO:0046825 regulation of protein export from nucleus; GO:0046827 positive regulation of protein export from nucleus; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0090316 positive regulation of intracellular protein transport; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1901360 organic cyclic compound metabolic process; GO:1903829 positive regulation of protein localization; GO:1904589 regulation of protein import; GO:1904591 positive regulation of protein import; GO:1904951 positive regulation of establishment of protein localization;","GO:0000974 Prp19 complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071006 U2-type catalytic step 1 spliceosome; GO:0071007 U2-type catalytic step 2 spliceosome; GO:0071012 catalytic step 1 spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003729 mRNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0017069 snRNA binding; GO:0017070 U6 snRNA binding; GO:0036002 pre-mRNA binding; GO:0048306 calcium-dependent protein binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","R","KOG0153","Predicted RNA-binding protein (RRM superfamily)",null,null,"Transcription factor","R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9NWU1","3-oxoacyl-[acyl-carrier-protein] synthase"," mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1","OXSM",1.572729543,1.89679E-4,"up",10286.7,11173.5,11372.4,17260.4,16746.9,17629.5,0.73068117,0.793672028,0.807800221,1.226034517,1.18955977,1.252252295,"mitochondria","K09458","fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]","hsa00061 Fatty acid biosynthesis; hsa01240 Biosynthesis of cofactors; hsa00780 Biotin metabolism; hsa01212 Fatty acid metabolism; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006633 fatty acid biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0016053 organic acid biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0035383 thioester metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046459 short-chain fatty acid metabolic process; GO:0046483 heterocycle metabolic process; GO:0051790 short-chain fatty acid biosynthetic process; GO:0051791 medium-chain fatty acid metabolic process; GO:0051792 medium-chain fatty acid biosynthetic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0072330 monocarboxylic acid biosynthetic process; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004312 fatty acid synthase activity; GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity; GO:0016740 transferase activity; GO:0016746 acyltransferase activity; GO:0016747 acyltransferase activity"," transferring groups other than amino-acyl groups;","PF00109; PF02801","PF00109 Beta-ketoacyl synthase"," N-terminal domain; PF02801 Beta-ketoacyl synthase"," C-terminal domain","IQ","KOG1394","3-oxoacyl-(acyl-carrier-protein) synthase (I and II)","WP4317 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY","http://www.wikipathways.org/instance/WP4317_r114309"]
["Q9NX02","NACHT"," LRR and PYD domains-containing protein 2 OS=Homo sapiens OX=9606 GN=NLRP2 PE=1 SV=1","NLRP2",1.060480905,0.04814348,"nochange",45511.9,46494.2,47214.7,50330.1,49816.2,47494.7,0.951926677,0.972472459,0.987542433,1.052704124,1.041955395,0.993398912,"cytoplasm","K19409",null,null,"GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001819 positive regulation of cytokine production; GO:0002237 response to molecule of bacterial origin; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002793 positive regulation of peptide secretion; GO:0006355 regulation of transcription"," DNA-templated; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010466 negative regulation of peptidase activity; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0010950 positive regulation of endopeptidase activity; GO:0010951 negative regulation of endopeptidase activity; GO:0010952 positive regulation of peptidase activity; GO:0010955 negative regulation of protein processing; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032496 response to lipopolysaccharide; GO:0032651 regulation of interleukin-1 beta production; GO:0032652 regulation of interleukin-1 production; GO:0032691 negative regulation of interleukin-1 beta production; GO:0032692 negative regulation of interleukin-1 production; GO:0032731 positive regulation of interleukin-1 beta production; GO:0032732 positive regulation of interleukin-1 production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043207 response to external biotic stimulus; GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050714 positive regulation of protein secretion; GO:0050727 regulation of inflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051047 positive regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051051 negative regulation of transport; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051222 positive regulation of protein transport; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0052547 regulation of peptidase activity; GO:0052548 regulation of endopeptidase activity; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070555 response to interleukin-1; GO:0070613 regulation of protein processing; GO:0070887 cellular response to chemical stimulus; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071347 cellular response to interleukin-1; GO:0071396 cellular response to lipid; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:1900015 regulation of cytokine production involved in inflammatory response; GO:1900016 negative regulation of cytokine production involved in inflammatory response; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903317 regulation of protein maturation; GO:1903318 negative regulation of protein maturation; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1903532 positive regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization; GO:1904951 positive regulation of establishment of protein localization; GO:1905245 regulation of aspartic-type peptidase activity; GO:1905246 negative regulation of aspartic-type peptidase activity; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000116 regulation of cysteine-type endopeptidase activity; GO:2001056 positive regulation of cysteine-type endopeptidase activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0002020 protease binding; GO:0004857 enzyme inhibitor activity; GO:0004866 endopeptidase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019828 aspartic-type endopeptidase inhibitor activity; GO:0019838 growth factor binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0019955 cytokine binding; GO:0019966 interleukin-1 binding; GO:0030234 enzyme regulator activity; GO:0030414 peptidase inhibitor activity; GO:0032090 Pyrin domain binding; GO:0061134 peptidase regulator activity; GO:0061135 endopeptidase regulator activity; GO:0089720 caspase binding; GO:0098772 molecular function regulator;","PF02758; PF05729; PF17779; PF17776","PF02758 PAAD/DAPIN/Pyrin domain; PF05729 NACHT domain; PF17779 NOD2 winged helix domain; PF17776 NLRC4 helical domain HD2",{"$nulls":3},"WP1433 NUCLEOTIDEBINDING OLIGOMERIZATION DOMAIN NOD PATHWAY","http://www.wikipathways.org/instance/WP1433_r117810"]
["Q9NXA8","NAD-dependent protein deacylase sirtuin-5"," mitochondrial OS=Homo sapiens OX=9606 GN=SIRT5 PE=1 SV=2","SIRT5",0.780776886,0.201668894,"nochange",5914.96,6254.7,4530.86,4623.83,5128.98,3286.57,1.193338243,1.261880504,0.914097223,0.932853843,1.034767434,0.663062754,"mitochondria","K11415","SIRT5; NAD+-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]","hsa00760 Nicotinate and nicotinamide metabolism; hsa01100 Metabolic pathways","GO:0006325 chromatin organization; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006471 protein ADP-ribosylation; GO:0006476 protein deacetylation; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009605 response to external stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0009991 response to extracellular stimulus; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010565 regulation of cellular ketone metabolic process; GO:0010566 regulation of ketone biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010656 negative regulation of muscle cell apoptotic process; GO:0010660 regulation of muscle cell apoptotic process; GO:0010662 regulation of striated muscle cell apoptotic process; GO:0010664 negative regulation of striated muscle cell apoptotic process; GO:0010665 regulation of cardiac muscle cell apoptotic process; GO:0010667 negative regulation of cardiac muscle cell apoptotic process; GO:0010941 regulation of cell death; GO:0016043 cellular component organization; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031667 response to nutrient levels; GO:0035601 protein deacylation; GO:0036046 protein demalonylation; GO:0036047 peptidyl-lysine demalonylation; GO:0036048 protein desuccinylation; GO:0036049 peptidyl-lysine desuccinylation; GO:0036211 protein modification process; GO:0040029 regulation of gene expression"," epigenetic; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045814 negative regulation of gene expression"," epigenetic; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0061698 protein deglutarylation; GO:0061699 peptidyl-lysine deglutarylation; GO:0062012 regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0098732 macromolecule deacylation; GO:1901564 organonitrogen compound metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000377 regulation of reactive oxygen species metabolic process; GO:2000378 negative regulation of reactive oxygen species metabolic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005758 mitochondrial intermembrane space; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0003950 NAD+ ADP-ribosyltransferase activity; GO:0005488 binding; GO:0008270 zinc ion binding; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016763 pentosyltransferase activity; GO:0016787 hydrolase activity; GO:0016810 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds; GO:0016811 hydrolase activity"," acting on carbon-nitrogen (but not peptide) bonds"," in linear amides; GO:0019213 deacetylase activity; GO:0033558 protein deacetylase activity; GO:0034979 NAD-dependent protein deacetylase activity; GO:0036054 protein-malonyllysine demalonylase activity; GO:0036055 protein-succinyllysine desuccinylase activity; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051287 NAD binding; GO:0061697 protein-glutaryllysine deglutarylase activity; GO:0070403 NAD+ binding; GO:0097159 organic cyclic compound binding; GO:0140096 catalytic activity"," acting on a protein; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"BK","KOG2684","Sirtuin 5 and related class III sirtuins (SIR2 family)","WP3645 NAD BIOSYNTHETIC PATHWAYS;WP3644 NAD METABOLISM;WP5046 NAD METABOLISM IN ONCOGENEINDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTIONASSOCIATED SENESCENCE","http://www.wikipathways.org/instance/WP3645_r118940;http://www.wikipathways.org/instance/WP3644_r118983;http://www.wikipathways.org/instance/WP5046_r118987",null,"R-HSA-1592230 Mitochondrial biogenesis;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-2151201"]
["Q9NXJ5","Pyroglutamyl-peptidase 1 OS=Homo sapiens OX=9606 GN=PGPEP1 PE=1 SV=1","PGPEP1",1.159699132,0.398556487,"nochange",7363.65,5418.33,5663.33,5728.06,7035.25,8627.7,1.109085879,0.816088936,0.852989935,0.862739329,1.059623479,1.299472441,"extracellular","K01304",null,null,"GO:0006508 proteolysis; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0019538 protein metabolic process; GO:0043170 macromolecule metabolic process; GO:0044238 primary metabolic process; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0008233 peptidase activity; GO:0016787 hydrolase activity; GO:0140096 catalytic activity"," acting on a protein;","PF01470","PF01470 Pyroglutamyl peptidase","O","KOG4755","Predicted pyroglutamyl peptidase"]
["Q9NYB9","Abl interactor 2 OS=Homo sapiens OX=9606 GN=ABI2 PE=1 SV=1","ABI2",0.797386148,0.013888146,"nochange",10788,12003.5,12658.1,9920.61,9167.61,9178.8,1.015873096,1.130333028,1.191974716,0.934193622,0.863285906,0.864339634,"nucleus","K05751","ABI2; abl interactor 2","hsa04810 Regulation of actin cytoskeleton","GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0001667 ameboidal-type cell migration; GO:0001736 establishment of planar polarity; GO:0001738 morphogenesis of a polarized epithelium; GO:0001764 neuron migration; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007030 Golgi organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007163 establishment or maintenance of cell polarity; GO:0007164 establishment of tissue polarity; GO:0007165 signal transduction; GO:0007264 small GTPase mediated signal transduction; GO:0007265 Ras protein signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007423 sensory organ development; GO:0007517 muscle organ development; GO:0007528 neuromuscular junction development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008152 metabolic process; GO:0008154 actin polymerization or depolymerization; GO:0008360 regulation of cell shape; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016203 muscle attachment; GO:0016310 phosphorylation; GO:0016333 morphogenesis of follicular epithelium; GO:0016334 establishment or maintenance of polarity of follicular epithelium; GO:0016358 dendrite development; GO:0016477 cell migration; GO:0016601 Rac protein signal transduction; GO:0018108 peptidyl-tyrosine phosphorylation; GO:0018193 peptidyl-amino acid modification; GO:0018212 peptidyl-tyrosine modification; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0021953 central nervous system neuron differentiation; GO:0021954 central nervous system neuron development; GO:0021955 central nervous system neuron axonogenesis; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022416 chaeta development; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030032 lamellipodium assembly; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032231 regulation of actin filament bundle assembly; GO:0032233 positive regulation of actin filament bundle assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032879 regulation of localization; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033043 regulation of organelle organization; GO:0033627 cell adhesion mediated by integrin; GO:0033674 positive regulation of kinase activity; GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040007 growth; GO:0040011 locomotion; GO:0042221 response to chemical; GO:0042247 establishment of planar polarity of follicular epithelium; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0043010 camera-type eye development; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045807 positive regulation of endocytosis; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048260 positive regulation of receptor-mediated endocytosis; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048846 axon extension involved in axon guidance; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050764 regulation of phagocytosis; GO:0050766 positive regulation of phagocytosis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051125 regulation of actin nucleation; GO:0051127 positive regulation of actin nucleation; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051489 regulation of filopodium assembly; GO:0051491 positive regulation of filopodium assembly; GO:0051492 regulation of stress fiber assembly; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051496 positive regulation of stress fiber assembly; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060100 positive regulation of phagocytosis"," engulfment; GO:0060255 regulation of macromolecule metabolic process; GO:0060269 centripetally migrating follicle cell migration; GO:0060429 epithelium development; GO:0060491 regulation of cell projection assembly; GO:0060538 skeletal muscle organ development; GO:0060560 developmental growth involved in morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0061061 muscle structure development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072499 photoreceptor cell axon guidance; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097435 supramolecular fiber organization; GO:0097485 neuron projection guidance; GO:0097581 lamellipodium organization; GO:0110020 regulation of actomyosin structure organization; GO:0110053 regulation of actin filament organization; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120032 regulation of plasma membrane bounded cell projection assembly; GO:0120034 positive regulation of plasma membrane bounded cell projection assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901074 regulation of engulfment of apoptotic cell; GO:1901076 positive regulation of engulfment of apoptotic cell; GO:1901564 organonitrogen compound metabolic process; GO:1902284 neuron projection extension involved in neuron projection guidance; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization; GO:1905153 regulation of membrane invagination; GO:1905155 positive regulation of membrane invagination; GO:1990138 neuron projection extension; GO:2000369 regulation of clathrin-dependent endocytosis; GO:2000370 positive regulation of clathrin-dependent endocytosis; GO:2000425 regulation of apoptotic cell clearance; GO:2000427 positive regulation of apoptotic cell clearance; GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005912 adherens junction; GO:0005938 cell cortex; GO:0016020 membrane; GO:0030027 lamellipodium; GO:0030054 cell junction; GO:0030175 filopodium; GO:0030424 axon; GO:0030425 dendrite; GO:0031209 SCAR complex; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031258 lamellipodium membrane; GO:0032433 filopodium tip; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0044297 cell body; GO:0045178 basal part of cell; GO:0045180 basal cortex; GO:0048471 perinuclear region of cytoplasm; GO:0070161 anchoring junction; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0099568 cytoplasmic region; GO:0099738 cell cortex region; GO:0120025 plasma membrane bounded cell projection;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008093 cytoskeletal anchor activity; GO:0017124 SH3 domain binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030674 protein-macromolecule adaptor activity; GO:0031625 ubiquitin protein ligase binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0044877 protein-containing complex binding; GO:0045296 cadherin binding; GO:0047485 protein N-terminus binding; GO:0050839 cell adhesion molecule binding; GO:0060090 molecular adaptor activity; GO:0070064 proline-rich region binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF14604","PF14604 Variant SH3 domain","TZ","KOG2546","Abl interactor ABI-1"," contains SH3 domain","WP51 REGULATION OF ACTIN CYTOSKELETON","http://www.wikipathways.org/instance/WP51_r116716",null,"R-HSA-162582 Signal Transduction;R-HSA-1643685 Disease;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-194138 Signaling by VEGF;R-HSA-194315 Signaling by Rho GTPases;R-HSA-195258 RHO GTPase Effectors;R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis;R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation;R-HSA-4420097 VEGFA-VEGFR2 Pathway;R-HSA-5663205 Infectious disease;R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9658195 Leishmania infection;R-HSA-9664407 Parasite infection;R-HSA-9664417 Leishmania phagocytosis;R-HSA-9664422 FCGR3A-mediated phagocytosis;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-194138;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-195258;https://reactome.org/PathwayBrowser/#/R-HSA-2029480;https://reactome.org/PathwayBrowser/#/R-HSA-2029482;https://reactome.org/PathwayBrowser/#/R-HSA-4420097;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-5663213;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9658195;https://reactome.org/PathwayBrowser/#/R-HSA-9664407;https://reactome.org/PathwayBrowser/#/R-HSA-9664417;https://reactome.org/PathwayBrowser/#/R-HSA-9664422;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q9NYF8","Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2","BCLAF1",1.520964986,{"v":7.01998e-05,"d":"7.02E-05"},"up",79349.2,80930.2,77261.9,124863,116243,120186,0.795037951,0.810878754,0.774124285,1.251062691,1.164694749,1.20420157,"nucleus","K13087",null,null,"GO:0000266 mitochondrial fission; GO:0006091 generation of precursor metabolites and energy; GO:0006355 regulation of transcription"," DNA-templated; GO:0006915 apoptotic process; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009060 aerobic respiration; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0012501 programmed cell death; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031334 positive regulation of protein-containing complex assembly; GO:0033554 cellular response to stress; GO:0034097 response to cytokine; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043254 regulation of protein-containing complex assembly; GO:0043620 regulation of DNA-templated transcription in response to stress; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0045333 cellular respiration; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000142 regulation of DNA-templated transcription"," initiation; GO:2000144 positive regulation of DNA-templated transcription"," initiation; GO:2001020 regulation of response to DNA damage stimulus; GO:2001022 positive regulation of response to DNA damage stimulus; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",{"$nulls":5},"WP2916 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2","http://www.wikipathways.org/instance/WP2916_r104425","Transcription factor"]
["Q9NZ52","ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1","GGA3",0.812662009,0.014749476,"nochange",12718.4,11393.7,12274.7,10499.3,9891.42,9179.45,1.156972493,1.036466654,1.116609814,0.955104517,0.899806647,0.835039875,"nucleus","K12404","GGA; ADP-ribosylation factor-binding protein GGA","hsa04142 Lysosome","GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042176 regulation of protein catabolic process; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0045732 positive regulation of protein catabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0055037 recycling endosome; GO:0055038 recycling endosome membrane; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding;","PF00790; PF03127; PF02883","PF00790 VHS domain; PF03127 GAT domain; PF02883 Adaptin C-terminal domain","U","KOG1087","Cytosolic sorting protein GGA2/TOM1",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-5653656 Vesicle-mediated transport;R-HSA-6806834 Signaling by MET;R-HSA-8854214 TBC/RABGAPs;R-HSA-8875656 MET receptor recycling;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-9007101 Rab regulation of trafficking;R-HSA-977225 Amyloid fiber formation","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-6806834;https://reactome.org/PathwayBrowser/#/R-HSA-8854214;https://reactome.org/PathwayBrowser/#/R-HSA-8875656;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-9007101;https://reactome.org/PathwayBrowser/#/R-HSA-977225"]
["Q9NZJ9","Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2","NUDT4",1.664267039,0.00563401,"up",35628.5,31648.5,25931.9,51205,53996.7,49922.8,0.860822588,0.76466154,0.626542382,1.237167453,1.304617905,1.206188133,"nucleus","K07766",null,null,"GO:0006066 alcohol metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006195 purine nucleotide catabolic process; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009125 nucleoside monophosphate catabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009128 purine nucleoside monophosphate catabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009154 purine ribonucleotide catabolic process; GO:0009158 ribonucleoside monophosphate catabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009166 nucleotide catabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009169 purine ribonucleoside monophosphate catabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009261 ribonucleotide catabolic process; GO:0009987 cellular process; GO:0015959 diadenosine polyphosphate metabolic process; GO:0015961 diadenosine polyphosphate catabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019722 calcium-mediated signaling; GO:0019751 polyol metabolic process; GO:0019932 second-messenger-mediated signaling; GO:0019935 cyclic-nucleotide-mediated signaling; GO:0023052 signaling; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0035556 intracellular signal transduction; GO:0043647 inositol phosphate metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046700 heterocycle catabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0071543 diphosphoinositol polyphosphate metabolic process; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072523 purine-containing compound catabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901906 diadenosine pentaphosphate metabolic process; GO:1901907 diadenosine pentaphosphate catabolic process; GO:1901908 diadenosine hexaphosphate metabolic process; GO:1901909 diadenosine hexaphosphate catabolic process; GO:1901910 adenosine 5'-(hexahydrogen pentaphosphate) metabolic process; GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000298 endopolyphosphatase activity; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004551 nucleotide diphosphatase activity; GO:0005488 binding; GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0030515 snoRNA binding; GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity; GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity; GO:0050072 m7G(5')pppN diphosphatase activity; GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity; GO:0052841 inositol bisdiphosphate tetrakisphosphate diphosphatase activity; GO:0052842 inositol diphosphate pentakisphosphate diphosphatase activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00293","PF00293 NUDIX domain","T","KOG2839","Diadenosine and diphosphoinositol polyphosphate phosphohydrolase",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483249 Inositol phosphate metabolism;R-HSA-1855167 Synthesis of pyrophosphates in the cytosol","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483249;https://reactome.org/PathwayBrowser/#/R-HSA-1855167","HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["Q9NZM5","Ribosome biogenesis protein NOP53 OS=Homo sapiens OX=9606 GN=NOP53 PE=1 SV=2","NOP53",0.931325963,0.165759486,"nochange",18894.6,17404.5,16522.9,16047.2,16796.4,16350.9,1.111267295,1.023628531,0.971778095,0.943800268,0.987863728,0.961662084,"nucleus","K14840",null,null,"GO:0000027 ribosomal large subunit assembly; GO:0000054 ribosomal subunit export from nucleus; GO:0000055 ribosomal large subunit export from nucleus; GO:0000075 cell cycle checkpoint signaling; GO:0000077 DNA damage checkpoint signaling; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0000278 mitotic cell cycle; GO:0001666 response to hypoxia; GO:0001817 regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0002682 regulation of immune system process; GO:0002697 regulation of immune effector process; GO:0002831 regulation of response to biotic stimulus; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006355 regulation of transcription"," DNA-templated; GO:0006356 regulation of transcription by RNA polymerase I; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006403 RNA localization; GO:0006405 RNA export from nucleus; GO:0006611 protein export from nucleus; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007049 cell cycle; GO:0007093 mitotic cell cycle checkpoint signaling; GO:0007095 mitotic G2 DNA damage checkpoint signaling; GO:0007346 regulation of mitotic cell cycle; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010389 regulation of G2/M transition of mitotic cell cycle; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0010948 negative regulation of cell cycle process; GO:0010972 negative regulation of G2/M transition of mitotic cell cycle; GO:0014066 regulation of phosphatidylinositol 3-kinase signaling; GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0016043 cellular component organization; GO:0016479 negative regulation of transcription by RNA polymerase I; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0031333 negative regulation of protein-containing complex assembly; GO:0031347 regulation of defense response; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0031503 protein-containing complex localization; GO:0031570 DNA integrity checkpoint signaling; GO:0031647 regulation of protein stability; GO:0032101 regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0033750 ribosome localization; GO:0034504 protein localization to nucleus; GO:0034613 cellular protein localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; GO:0039535 regulation of RIG-I signaling pathway; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042221 response to chemical; GO:0042254 ribosome biogenesis; GO:0042255 ribosome assembly; GO:0042273 ribosomal large subunit biogenesis; GO:0042325 regulation of phosphorylation; GO:0042886 amide transport; GO:0042981 regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043457 regulation of cellular respiration; GO:0043467 regulation of generation of precursor metabolites and energy; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044773 mitotic DNA damage checkpoint signaling; GO:0044774 mitotic DNA integrity checkpoint signaling; GO:0044818 mitotic G2/M transition checkpoint; GO:0045088 regulation of innate immune response; GO:0045184 establishment of protein localization; GO:0045732 positive regulation of protein catabolic process; GO:0045786 negative regulation of cell cycle; GO:0045861 negative regulation of proteolysis; GO:0045862 positive regulation of proteolysis; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045930 negative regulation of mitotic cell cycle; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050688 regulation of defense response to virus; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051168 nuclear export; GO:0051169 nuclear transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0051896 regulation of protein kinase B signaling; GO:0051898 negative regulation of protein kinase B signaling; GO:0060255 regulation of macromolecule metabolic process; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070482 response to oxygen levels; GO:0070727 cellular macromolecule localization; GO:0070887 cellular response to chemical stimulus; GO:0070925 organelle assembly; GO:0071166 ribonucleoprotein complex localization; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090085 regulation of protein deubiquitination; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901796 regulation of signal transduction by p53 class mediator; GO:1901797 negative regulation of signal transduction by p53 class mediator; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1901800 positive regulation of proteasomal protein catabolic process; GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I; GO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; GO:1901857 positive regulation of cellular respiration; GO:1901987 regulation of cell cycle phase transition; GO:1901988 negative regulation of cell cycle phase transition; GO:1901990 regulation of mitotic cell cycle phase transition; GO:1901991 negative regulation of mitotic cell cycle phase transition; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902570 protein localization to nucleolus; GO:1902679 negative regulation of RNA biosynthetic process; GO:1902749 regulation of cell cycle G2/M phase transition; GO:1902750 negative regulation of cell cycle G2/M phase transition; GO:1903003 positive regulation of protein deubiquitination; GO:1903004 regulation of protein K63-linked deubiquitination; GO:1903006 positive regulation of protein K63-linked deubiquitination; GO:1903047 mitotic cell cycle process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903715 regulation of aerobic respiration; GO:1990173 protein localization to nucleoplasm; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0002039 p53 binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008097 5S rRNA binding; GO:0019843 rRNA binding; GO:0042802 identical protein binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG2823","Cellular protein (glioma tumor suppressor candidate region gene 2)"]
["Q9P0K8","Forkhead box protein J2 OS=Homo sapiens OX=9606 GN=FOXJ2 PE=1 SV=1","FOXJ2",1.820762036,0.126495817,"nochange",614.115,1916.29,1239.89,2324.56,2767.91,1772.34,0.346464844,1.081112034,0.699507903,1.311445444,1.561569914,0.99989986,"nucleus","K09403",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008284 positive regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016525 negative regulation of angiogenesis; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0030154 cell differentiation; GO:0030856 regulation of epithelial cell differentiation; GO:0030857 negative regulation of epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042127 regulation of cell population proliferation; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045601 regulation of endothelial cell differentiation; GO:0045602 negative regulation of endothelial cell differentiation; GO:0045765 regulation of angiogenesis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048660 regulation of smooth muscle cell proliferation; GO:0048661 positive regulation of smooth muscle cell proliferation; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0110057 regulation of blood vessel endothelial cell differentiation; GO:0110059 negative regulation of blood vessel endothelial cell differentiation; GO:1901342 regulation of vasculature development; GO:1901343 negative regulation of vasculature development; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1904705 regulation of vascular associated smooth muscle cell proliferation; GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000181 negative regulation of blood vessel morphogenesis; GO:2001141 regulation of RNA biosynthetic process;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00250","PF00250 Forkhead domain","K","KOG2294","Transcription factor of the Forkhead/HNF3 family",null,null,"Transcription factor",null,null,"HEME METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM"]
["Q9P0T4","Zinc finger protein 581 OS=Homo sapiens OX=9606 GN=ZNF581 PE=1 SV=1","ZNF581",1.174255396,0.055319146,"nochange",1860.2,1743.36,1997.07,2222.38,2009.87,2344.32,0.916565384,0.8589955,0.984004533,1.095020202,0.990311402,1.155102979,"nucleus",{"$nulls":3},"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;",null,"GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00096; PF13894","PF00096 Zinc finger"," C2H2 type; PF13894 C2H2-type zinc finger","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["Q9P2B4","CTTNBP2 N-terminal-like protein OS=Homo sapiens OX=9606 GN=CTTNBP2NL PE=1 SV=2","CTTNBP2NL",1.900062594,0.012560288,"nochange",2235.44,2699.28,1727.25,4046.53,4872.81,3738.82,0.694231354,0.838280074,0.536409434,1.256677879,1.513284848,1.161116411,"nucleus",{"$nulls":3},"GO:0006464 cellular protein modification process; GO:0006470 protein dephosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016311 dephosphorylation; GO:0019538 protein metabolic process; GO:0032409 regulation of transporter activity; GO:0032410 negative regulation of transporter activity; GO:0032879 regulation of localization; GO:0034762 regulation of transmembrane transport; GO:0034763 negative regulation of transmembrane transport; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005856 cytoskeleton; GO:0015629 actin cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0051721 protein phosphatase 2A binding;",null,null,"S","KOG1103","Predicted coiled-coil protein"]
["Q9P2W1","Homologous-pairing protein 2 homolog OS=Homo sapiens OX=9606 GN=PSMC3IP PE=1 SV=1","PSMC3IP",0.962478158,0.713716905,"nochange",4244.94,4579,5477.33,4507.9,4971.04,4285.72,0.907493178,0.978909304,1.170956387,0.96370938,1.06272053,0.916211221,"cytoplasm","K06695",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0019904 protein domain specific binding; GO:0030331 estrogen receptor binding; GO:0030374 nuclear receptor coactivator activity; GO:0035259 glucocorticoid receptor binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046966 thyroid hormone receptor binding; GO:0046983 protein dimerization activity; GO:0050681 androgen receptor binding; GO:0050692 DNA binding domain binding; GO:0051427 hormone receptor binding; GO:0140110 transcription regulator activity;","PF07106; PF18517","PF07106 TBPIP/Hop2 winged helix domain; PF18517 Leucine zipper with capping helix domain","T","KOG4603","TBP-1 interacting protein","WP138 ANDROGEN RECEPTOR SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP138_r120688",null,"R-HSA-1474165 Reproduction;R-HSA-1500620 Meiosis;R-HSA-1640170 Cell Cycle;R-HSA-912446 Meiotic recombination","https://reactome.org/PathwayBrowser/#/R-HSA-1474165;https://reactome.org/PathwayBrowser/#/R-HSA-1500620;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-912446","E2F TARGETS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_E2F_TARGETS"]
["Q9UBB6","Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1","NCDN",0.969852923,0.308935726,"nochange",14523,14743.5,14336.4,14501.7,14398.8,13387.9,1.014514858,1.029918048,1.001479777,1.013026931,1.005838775,0.935221612,"plasma membrane",{"$nulls":3},"GO:0001894 tissue homeostasis; GO:0003008 system process; GO:0003012 muscle system process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0016043 cellular component organization; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0042592 homeostatic process; GO:0045453 bone resorption; GO:0046849 bone remodeling; GO:0048167 regulation of synaptic plasticity; GO:0048168 regulation of neuronal synaptic plasticity; GO:0048468 cell development; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048771 tissue remodeling; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048871 multicellular organismal homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050804 modulation of chemical synaptic transmission; GO:0060249 anatomical structure homeostasis; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0099177 regulation of trans-synaptic signaling; GO:0120036 plasma membrane bounded cell projection organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030425 dendrite; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0044297 cell body; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection;",{"$nulls":3},"S","KOG2611","Neurochondrin/leucine-rich protein (Neurochondrin)","WP4148 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS","http://www.wikipathways.org/instance/WP4148_r110682"]
["Q9UBM7","7-dehydrocholesterol reductase OS=Homo sapiens OX=9606 GN=DHCR7 PE=1 SV=1","DHCR7",0.961321605,0.259795029,"nochange",25955.4,27759.7,27356,26573.9,26521.2,24840.3,0.979409018,1.047493027,1.032259687,1.002747686,1.000759088,0.937331493,"plasma membrane","K00213","DHCR7; 7-dehydrocholesterol reductase [EC:1.3.1.21]","hsa00100 Steroid biosynthesis; hsa01100 Metabolic pathways","GO:0001568 blood vessel development; GO:0001944 vasculature development; GO:0006066 alcohol metabolic process; GO:0006629 lipid metabolic process; GO:0006694 steroid biosynthetic process; GO:0006695 cholesterol biosynthetic process; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008202 steroid metabolic process; GO:0008203 cholesterol metabolic process; GO:0008610 lipid biosynthetic process; GO:0009058 biosynthetic process; GO:0009791 post-embryonic development; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010817 regulation of hormone levels; GO:0016125 sterol metabolic process; GO:0016126 sterol biosynthetic process; GO:0016128 phytosteroid metabolic process; GO:0016129 phytosteroid biosynthetic process; GO:0016131 brassinosteroid metabolic process; GO:0016132 brassinosteroid biosynthetic process; GO:0019216 regulation of lipid metabolic process; GO:0019218 regulation of steroid metabolic process; GO:0019222 regulation of metabolic process; GO:0030154 cell differentiation; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033489 cholesterol biosynthetic process via desmosterol; GO:0033490 cholesterol biosynthetic process via lathosterol; GO:0035264 multicellular organism growth; GO:0035295 tube development; GO:0040007 growth; GO:0042127 regulation of cell population proliferation; GO:0042445 hormone metabolic process; GO:0042446 hormone biosynthetic process; GO:0044238 primary metabolic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045540 regulation of cholesterol biosynthetic process; GO:0046165 alcohol biosynthetic process; GO:0046890 regulation of lipid biosynthetic process; GO:0048513 animal organ development; GO:0048589 developmental growth; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050810 regulation of steroid biosynthetic process; GO:0060541 respiratory system development; GO:0062012 regulation of small molecule metabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090181 regulation of cholesterol metabolic process; GO:0106118 regulation of sterol biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process; GO:1902652 secondary alcohol metabolic process; GO:1902653 secondary alcohol biosynthetic process; GO:1902930 regulation of alcohol biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005640 nuclear outer membrane; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019867 outer membrane; GO:0030176 integral component of endoplasmic reticulum membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031227 intrinsic component of endoplasmic reticulum membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098588 bounding membrane of organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0000166 nucleotide binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0009918 sterol delta7 reductase activity; GO:0016491 oxidoreductase activity; GO:0016627 oxidoreductase activity"," acting on the CH-CH group of donors; GO:0016628 oxidoreductase activity"," acting on the CH-CH group of donors"," NAD or NADP as acceptor; GO:0036094 small molecule binding; GO:0047598 7-dehydrocholesterol reductase activity; GO:0050661 NADP binding; GO:0097159 organic cyclic compound binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"IT","KOG1435","Sterol reductase/lamin B receptor","WP5064 7OXOC AND 7BETAHC PATHWAYS;WP197 CHOLESTEROL BIOSYNTHESIS PATHWAY;WP4804 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS;WP4718 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCHRUSSELL PATHWAYS;WP4545 OXYSTEROLS DERIVED FROM CHOLESTEROL;WP1531 VITAMIN D METABOLISM","http://www.wikipathways.org/instance/WP5064_r120384;http://www.wikipathways.org/instance/WP197_r120482;http://www.wikipathways.org/instance/WP4804_r117680;http://www.wikipathways.org/instance/WP4718_r119764;http://www.wikipathways.org/instance/WP4545_r120411;http://www.wikipathways.org/instance/WP1531_r118354",null,"R-HSA-1430728 Metabolism;R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF);R-HSA-191273 Cholesterol biosynthesis;R-HSA-2426168 Activation of gene expression by SREBF (SREBP);R-HSA-556833 Metabolism of lipids;R-HSA-6807047 Cholesterol biosynthesis via desmosterol;R-HSA-6807062 Cholesterol biosynthesis via lathosterol;R-HSA-8957322 Metabolism of steroids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1655829;https://reactome.org/PathwayBrowser/#/R-HSA-191273;https://reactome.org/PathwayBrowser/#/R-HSA-2426168;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-6807047;https://reactome.org/PathwayBrowser/#/R-HSA-6807062;https://reactome.org/PathwayBrowser/#/R-HSA-8957322","ADIPOGENESIS;CHOLESTEROL HOMEOSTASIS;ESTROGEN RESPONSE EARLY;ESTROGEN RESPONSE LATE;MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_CHOLESTEROL_HOMEOSTASIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["Q9UBQ5","Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1","EIF3K",0.895031148,0.015044408,"nochange",105744,113802,111456,97240,101941,97076.1,1.011486322,1.088564518,1.066124031,0.930141946,0.97510901,0.928574173,"cytoplasm","K15028",null,null,"GO:0006412 translation; GO:0006413 translational initiation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0019538 protein metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0042981 regulation of apoptotic process; GO:0043043 peptide biosynthetic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005852 eukaryotic translation initiation factor 3 complex; GO:0032991 protein-containing complex;",{"$nulls":3},"S","KOG3252","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-392499 Metabolism of proteins;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72649 Translation initiation complex formation;R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72695 Formation of the ternary complex"," and subsequently"," the 43S complex;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-156827;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72649;https://reactome.org/PathwayBrowser/#/R-HSA-72662;https://reactome.org/PathwayBrowser/#/R-HSA-72689;https://reactome.org/PathwayBrowser/#/R-HSA-72695;https://reactome.org/PathwayBrowser/#/R-HSA-72702;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q9UDT6","CAP-Gly domain-containing linker protein 2 OS=Homo sapiens OX=9606 GN=CLIP2 PE=1 SV=1","CLIP2",1.00328115,0.964667207,"nochange",12646.1,12081.5,11235.4,11013.5,12626.6,12440.9,1.053198046,1.006176781,0.93571151,0.917231137,1.051574038,1.036108489,"nucleus","K10422",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0001578 microtubule bundle formation; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007026 negative regulation of microtubule depolymerization; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0007349 cellularization; GO:0009653 anatomical structure morphogenesis; GO:0009987 cellular process; GO:0010638 positive regulation of organelle organization; GO:0010639 negative regulation of organelle organization; GO:0016043 cellular component organization; GO:0031110 regulation of microtubule polymerization or depolymerization; GO:0031111 negative regulation of microtubule polymerization or depolymerization; GO:0031112 positive regulation of microtubule polymerization or depolymerization; GO:0031113 regulation of microtubule polymerization; GO:0031114 regulation of microtubule depolymerization; GO:0031116 positive regulation of microtubule polymerization; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032886 regulation of microtubule-based process; GO:0033043 regulation of organelle organization; GO:0043242 negative regulation of protein-containing complex disassembly; GO:0043244 regulation of protein-containing complex disassembly; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0065007 biological regulation; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0071840 cellular component organization or biogenesis; GO:1901879 regulation of protein depolymerization; GO:1901880 negative regulation of protein depolymerization; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization;","GO:0000775 chromosome"," centromeric region; GO:0000776 kinetochore; GO:0005622 intracellular anatomical structure; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005875 microtubule associated complex; GO:0005876 spindle microtubule; GO:0005881 cytoplasmic microtubule; GO:0005882 intermediate filament; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0030141 secretory granule; GO:0030424 axon; GO:0030425 dendrite; GO:0030426 growth cone; GO:0030427 site of polarized growth; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0035371 microtubule plus-end; GO:0036477 somatodendritic compartment; GO:0042599 lamellar body; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044295 axonal growth cone; GO:0045111 intermediate filament cytoskeleton; GO:0045169 fusome; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098687 chromosomal region; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099503 secretory vesicle; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon; GO:1901588 dendritic microtubule; GO:1990752 microtubule end;","GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0008270 zinc ion binding; GO:0015631 tubulin binding; GO:0017022 myosin binding; GO:0032036 myosin heavy chain binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0046983 protein dimerization activity; GO:0051010 microtubule plus-end binding; GO:0070853 myosin VI binding; GO:0070854 myosin VI heavy chain binding;","PF01302","PF01302 CAP-Gly domain","ZR","KOG4568","Cytoskeleton-associated protein and related proteins","WP4932 7Q1123 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4932_r118797",{"$nulls":3},"MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q9UEG4","Zinc finger protein 629 OS=Homo sapiens OX=9606 GN=ZNF629 PE=1 SV=2","ZNF629",1.163865011,0.129900485,"nochange",5437.74,6732.86,5582,6483.25,7514.16,6664.22,0.849332136,1.051619673,0.871864411,1.012632558,1.173652576,1.040898646,"nucleus",{"$nulls":3},"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;",null,"GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["Q9UGJ1","Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1","TUBGCP4",0.589500242,0.008910537,"down",21918.7,17987.9,20932.9,10015.4,13914.3,11935.2,1.359940189,1.116054699,1.298776478,0.621402956,0.863309219,0.74051646,"extracellular","K16571",null,null,"GO:0000003 reproduction; GO:0000212 meiotic spindle organization; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000578 embryonic axis specification; GO:0000910 cytokinesis; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006403 RNA localization; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007020 microtubule nucleation; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007056 spindle assembly involved in female meiosis; GO:0007058 spindle assembly involved in female meiosis II; GO:0007098 centrosome cycle; GO:0007112 male meiosis cytokinesis; GO:0007135 meiosis II; GO:0007140 male meiotic nuclear division; GO:0007143 female meiotic nuclear division; GO:0007147 female meiosis II; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0008298 intracellular mRNA localization; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0016043 cellular component organization; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031023 microtubule organizing center organization; GO:0031109 microtubule polymerization or depolymerization; GO:0031122 cytoplasmic microtubule organization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033206 meiotic cytokinesis; GO:0035282 segmentation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045450 bicoid mRNA localization; GO:0046785 microtubule polymerization; GO:0048232 male gamete generation; GO:0048285 organelle fission; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051258 protein polymerization; GO:0051298 centrosome duplication; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051415 microtubule nucleation by interphase microtubule organizing center; GO:0051418 microtubule nucleation by microtubule organizing center; GO:0051641 cellular localization; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0061983 meiosis II cell cycle process; GO:0065003 protein-containing complex assembly; GO:0070727 cellular macromolecule localization; GO:0070925 organelle assembly; GO:0071840 cellular component organization or biogenesis; GO:0090306 meiotic spindle assembly; GO:0090307 mitotic spindle assembly; GO:0097435 supramolecular fiber organization; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process;","GO:0000923 equatorial microtubule organizing center; GO:0000930 gamma-tubulin complex; GO:0000931 gamma-tubulin large complex; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032153 cell division site; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0055037 recycling endosome; GO:0097708 intracellular vesicle;","GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0043015 gamma-tubulin binding;","PF17681; PF04130","PF17681 Gamma tubulin complex component N-terminal; PF04130 Gamma tubulin complex component C-terminal","Z","KOG2065","Gamma-tubulin ring complex protein","WP4940 15Q112 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4940_r115775",null,"R-HSA-1640170 Cell Cycle;R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes;R-HSA-380287 Centrosome maturation;R-HSA-380320 Recruitment of NuMA to mitotic centrosomes;R-HSA-453274 Mitotic G2-G2/M phases;R-HSA-68877 Mitotic Prometaphase;R-HSA-68886 M Phase;R-HSA-69275 G2/M Transition;R-HSA-69278 Cell Cycle"," Mitotic","https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-380270;https://reactome.org/PathwayBrowser/#/R-HSA-380287;https://reactome.org/PathwayBrowser/#/R-HSA-380320;https://reactome.org/PathwayBrowser/#/R-HSA-453274;https://reactome.org/PathwayBrowser/#/R-HSA-68877;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69275;https://reactome.org/PathwayBrowser/#/R-HSA-69278"]
["Q9UGP5","DNA polymerase lambda OS=Homo sapiens OX=9606 GN=POLL PE=1 SV=1","POLL",0.599479404,0.099661907,"nochange",4625.46,2783.77,2986.54,2882.76,1781.04,1568.25,1.669055835,1.004498485,1.077666224,1.04021814,0.642672341,0.565888974,"nucleus","K03512","POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]","hsa03450 Non-homologous end-joining; hsa03410 Base excision repair","GO:0000724 double-strand break repair via homologous recombination; GO:0000725 recombinational repair; GO:0002200 somatic diversification of immune receptors; GO:0002376 immune system process; GO:0002377 immunoglobulin production; GO:0002440 production of molecular mediator of immune response; GO:0002520 immune system development; GO:0002566 somatic diversification of immune receptors via somatic mutation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006281 DNA repair; GO:0006284 base-excision repair; GO:0006287 base-excision repair"," gap-filling; GO:0006289 nucleotide-excision repair; GO:0006302 double-strand break repair; GO:0006303 double-strand break repair via nonhomologous end joining; GO:0006310 DNA recombination; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0016445 somatic diversification of immunoglobulins; GO:0016446 somatic hypermutation of immunoglobulin genes; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0071704 organic substance metabolic process; GO:0071897 DNA biosynthetic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003824 catalytic activity; GO:0003887 DNA-directed DNA polymerase activity; GO:0005488 binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0016829 lyase activity; GO:0016835 carbon-oxygen lyase activity; GO:0034061 DNA polymerase activity; GO:0051575 5'-deoxyribose-5-phosphate lyase activity; GO:0097159 organic cyclic compound binding; GO:0140097 catalytic activity"," acting on DNA; GO:1901363 heterocyclic compound binding;","PF14716; PF10391; PF14792","PF14716 Helix-hairpin-helix domain; PF10391 Fingers domain of DNA polymerase lambda; PF14792 DNA polymerase beta palm ","L","KOG2534","DNA polymerase IV (family X)","WP4752 BASE EXCISION REPAIR;WP4946 DNA REPAIR PATHWAYS FULL NETWORK;WP438 NONHOMOLOGOUS END JOINING","http://www.wikipathways.org/instance/WP4752_r119239;http://www.wikipathways.org/instance/WP4946_r117703;http://www.wikipathways.org/instance/WP438_r119305",null,"R-HSA-5693532 DNA Double-Strand Break Repair;R-HSA-5693571 Nonhomologous End-Joining (NHEJ);R-HSA-73894 DNA Repair","https://reactome.org/PathwayBrowser/#/R-HSA-5693532;https://reactome.org/PathwayBrowser/#/R-HSA-5693571;https://reactome.org/PathwayBrowser/#/R-HSA-73894","DNA REPAIR","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_DNA_REPAIR"]
["Q9UHD1","Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2","CHORDC1",1.164720209,0.006341213,"up",37893,35370.7,36525.5,41320.3,42175.9,44377.5,0.956640687,0.8929631,0.922116998,1.043165761,1.064766104,1.120347349,"cytoplasm","K16729",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0006457 protein folding; GO:0006469 negative regulation of protein kinase activity; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007098 centrosome cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008361 regulation of cell size; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010824 regulation of centrosome duplication; GO:0010975 regulation of neuron projection development; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0030154 cell differentiation; GO:0031023 microtubule organizing center organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032886 regulation of microtubule-based process; GO:0033043 regulation of organelle organization; GO:0033673 negative regulation of kinase activity; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046605 regulation of centrosome cycle; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051298 centrosome duplication; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0061077 chaperone-mediated protein folding; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070507 regulation of microtubule cytoskeleton organization; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090066 regulation of anatomical structure size; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900034 regulation of cellular response to heat; GO:2000026 regulation of multicellular organismal development; GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity; GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity;",null,"GO:0000166 nucleotide binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005524 ATP binding; GO:0008270 zinc ion binding; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0031072 heat shock protein binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0043531 ADP binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0051879 Hsp90 protein binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF04969","PF04969 CS domain","R","KOG1667","Zn2+-binding protein Melusin/RAR1"," contains CHORD domain"]
["Q9UHN1","DNA polymerase subunit gamma-2"," mitochondrial OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1","POLG2",1.103296048,0.208149335,"nochange",8455.13,8006.29,7855.58,8079.41,9924.15,8825.29,0.991884581,0.939230456,0.921550429,0.947808278,1.164217625,1.035308632,"mitochondria","K02333",null,null,"GO:0000002 mitochondrial genome maintenance; GO:0000959 mitochondrial RNA metabolic process; GO:0001701 in utero embryonic development; GO:0006082 organic acid metabolic process; GO:0006091 generation of precursor metabolites and energy; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006260 DNA replication; GO:0006261 DNA-dependent DNA replication; GO:0006281 DNA repair; GO:0006399 tRNA metabolic process; GO:0006412 translation; GO:0006418 tRNA aminoacylation for protein translation; GO:0006426 glycyl-tRNA aminoacylation; GO:0006518 peptide metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010467 gene expression; GO:0015980 energy derivation by oxidation of organic compounds; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019538 protein metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022900 electron transport chain; GO:0022904 respiratory electron transport chain; GO:0032042 mitochondrial DNA metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032543 mitochondrial translation; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0043009 chordate embryonic development; GO:0043038 amino acid activation; GO:0043039 tRNA aminoacylation; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0045333 cellular respiration; GO:0046483 heterocycle metabolic process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0070127 tRNA aminoacylation for mitochondrial protein translation; GO:0070150 mitochondrial glycyl-tRNA aminoacylation; GO:0070584 mitochondrion morphogenesis; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071897 DNA biosynthetic process; GO:0090304 nucleic acid metabolic process; GO:0140053 mitochondrial gene expression; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000262 mitochondrial chromosome; GO:0005622 intracellular anatomical structure; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0009295 nucleoid; GO:0031974 membrane-enclosed lumen; GO:0042645 mitochondrial nucleoid; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0003887 DNA-directed DNA polymerase activity; GO:0004812 aminoacyl-tRNA ligase activity; GO:0004820 glycine-tRNA ligase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0016874 ligase activity; GO:0016875 ligase activity"," forming carbon-oxygen bonds; GO:0034061 DNA polymerase activity; GO:0042802 identical protein binding; GO:0140097 catalytic activity"," acting on DNA; GO:0140098 catalytic activity"," acting on RNA; GO:0140101 catalytic activity"," acting on a tRNA;","PF03129","PF03129 Anticodon binding domain","J","KOG2298","Glycyl-tRNA synthetase and related class II tRNA synthetase",{"$nulls":3},"R-HSA-1592230 Mitochondrial biogenesis;R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis","https://reactome.org/PathwayBrowser/#/R-HSA-1592230;https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-2151201","UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["Q9UI12","V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1","ATP6V1H",1.228238323,0.054376763,"nochange",13203,15307.4,14298.8,19458.1,15683,17438.8,0.830472245,0.96283957,0.899398359,1.223919714,0.986464911,1.096905202,"cytoplasm","K02144","ATPeV1H; V-type H+-transporting ATPase subunit H","hsa05120 Epithelial cell signaling in Helicobacter pylori infection; hsa04721 Synaptic vesicle cycle; hsa04142 Lysosome; hsa04150 mTOR signaling pathway; hsa05152 Tuberculosis; hsa00190 Oxidative phosphorylation; hsa05110 Vibrio cholerae infection; hsa05165 Human papillomavirus infection; hsa04145 Phagosome; hsa05323 Rheumatoid arthritis; hsa01100 Metabolic pathways","GO:0000041 transition metal ion transport; GO:0006403 RNA localization; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006826 iron ion transport; GO:0006873 cellular ion homeostasis; GO:0006885 regulation of pH; GO:0006897 endocytosis; GO:0007035 vacuolar acidification; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008104 protein localization; GO:0008286 insulin receptor signaling pathway; GO:0008340 determination of adult lifespan; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009894 regulation of catabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010259 multicellular organism aging; GO:0010506 regulation of autophagy; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0015931 nucleobase-containing compound transport; GO:0015988 energy coupled proton transmembrane transport"," against electrochemical gradient; GO:0016032 viral process; GO:0016192 vesicle-mediated transport; GO:0016241 regulation of macroautophagy; GO:0019222 regulation of metabolic process; GO:0019725 cellular homeostasis; GO:0023052 signaling; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030641 regulation of cellular pH; GO:0031323 regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032868 response to insulin; GO:0032869 cellular response to insulin stimulus; GO:0032870 cellular response to hormone stimulus; GO:0033036 macromolecule localization; GO:0033227 dsRNA transport; GO:0033572 transferrin transport; GO:0034220 ion transmembrane transport; GO:0042221 response to chemical; GO:0042592 homeostatic process; GO:0042886 amide transport; GO:0043434 response to peptide hormone; GO:0044403 biological process involved in symbiotic interaction; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0045184 establishment of protein localization; GO:0045851 pH reduction; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050657 nucleic acid transport; GO:0050658 RNA transport; GO:0050690 regulation of defense response to virus by virus; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051236 establishment of RNA localization; GO:0051452 intracellular pH reduction; GO:0051453 regulation of intracellular pH; GO:0051716 cellular response to stimulus; GO:0055067 monovalent inorganic cation homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071375 cellular response to peptide hormone stimulus; GO:0071417 cellular response to organonitrogen compound; GO:0071495 cellular response to endogenous stimulus; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0098655 cation transmembrane transport; GO:0098657 import into cell; GO:0098660 inorganic ion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098771 inorganic ion homeostasis; GO:1901652 response to peptide; GO:1901653 cellular response to peptide; GO:1901698 response to nitrogen compound; GO:1901699 cellular response to nitrogen compound; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902600 proton transmembrane transport;","GO:0000221 vacuolar proton-transporting V-type ATPase"," V1 domain; GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005765 lysosomal membrane; GO:0005773 vacuole; GO:0005774 vacuolar membrane; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0016469 proton-transporting two-sector ATPase complex; GO:0016471 vacuolar proton-transporting V-type ATPase complex; GO:0031090 organelle membrane; GO:0032991 protein-containing complex; GO:0033176 proton-transporting V-type ATPase complex; GO:0033178 proton-transporting two-sector ATPase complex"," catalytic domain; GO:0033180 proton-transporting V-type ATPase"," V1 domain; GO:0033181 plasma membrane proton-transporting V-type ATPase complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071944 cell periphery; GO:0098588 bounding membrane of organelle; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex; GO:0098852 lytic vacuole membrane;","GO:0003824 catalytic activity; GO:0005215 transporter activity; GO:0008324 cation transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015078 proton transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0016887 ATP hydrolysis activity; GO:0017111 nucleoside-triphosphatase activity; GO:0019829 ATPase-coupled cation transmembrane transporter activity; GO:0022804 active transmembrane transporter activity; GO:0022853 active ion transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0030234 enzyme regulator activity; GO:0042625 ATPase-coupled ion transmembrane transporter activity; GO:0042626 ATPase-coupled transmembrane transporter activity; GO:0044769 ATPase activity"," coupled to transmembrane movement of ions"," rotational mechanism; GO:0046961 proton-transporting ATPase activity"," rotational mechanism; GO:0098772 molecular function regulator;",null,null,"C","KOG2759","Vacuolar H+-ATPase V1 sector"," subunit H","WP4917 PROXIMAL TUBULE TRANSPORT","http://www.wikipathways.org/instance/WP4917_r119111",null,"R-HSA-1222556 ROS and RNS production in phagocytes;R-HSA-162582 Signal Transduction;R-HSA-162906 HIV Infection;R-HSA-162909 Host Interactions of HIV factors;R-HSA-1643685 Disease;R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters;R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis;R-HSA-167590 Nef Mediated CD4 Down-regulation;R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-182218 Nef Mediated CD8 Down-regulation;R-HSA-2262752 Cellular responses to stress;R-HSA-382551 Transport of small molecules;R-HSA-5663205 Infectious disease;R-HSA-74752 Signaling by Insulin receptor;R-HSA-77387 Insulin receptor recycling;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9006934 Signaling by Receptor Tyrosine Kinases;R-HSA-917937 Iron uptake and transport;R-HSA-917977 Transferrin endocytosis and recycling;R-HSA-9635486 Infection with Mycobacterium tuberculosis;R-HSA-9636467 Blockage of phagosome acidification;R-HSA-9637687 Suppression of phagosomal maturation;R-HSA-9637690 Response of Mtb to phagocytosis;R-HSA-9639288 Amino acids regulate mTORC1;R-HSA-9711097 Cellular response to starvation;R-HSA-983712 Ion channel transport","https://reactome.org/PathwayBrowser/#/R-HSA-1222556;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-162906;https://reactome.org/PathwayBrowser/#/R-HSA-162909;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-164938;https://reactome.org/PathwayBrowser/#/R-HSA-164952;https://reactome.org/PathwayBrowser/#/R-HSA-167590;https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-182218;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-74752;https://reactome.org/PathwayBrowser/#/R-HSA-77387;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9006934;https://reactome.org/PathwayBrowser/#/R-HSA-917937;https://reactome.org/PathwayBrowser/#/R-HSA-917977;https://reactome.org/PathwayBrowser/#/R-HSA-9635486;https://reactome.org/PathwayBrowser/#/R-HSA-9636467;https://reactome.org/PathwayBrowser/#/R-HSA-9637687;https://reactome.org/PathwayBrowser/#/R-HSA-9637690;https://reactome.org/PathwayBrowser/#/R-HSA-9639288;https://reactome.org/PathwayBrowser/#/R-HSA-9711097;https://reactome.org/PathwayBrowser/#/R-HSA-983712","OXIDATIVE PHOSPHORYLATION;PROTEIN SECRETION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PROTEIN_SECRETION"]
["Q9UII2","ATPase inhibitor"," mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1","ATP5IF1",0.844942753,0.689228334,"nochange",853.39,2147.06,1274.9,723.256,1177.22,1711.95,0.649148759,1.633205608,0.969779061,0.550159639,0.895476748,1.302230185,"mitochondria","K22255",null,null,"GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001936 regulation of endothelial cell proliferation; GO:0001937 negative regulation of endothelial cell proliferation; GO:0001944 vasculature development; GO:0002262 myeloid cell homeostasis; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006091 generation of precursor metabolites and energy; GO:0006140 regulation of nucleotide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006778 porphyrin-containing compound metabolic process; GO:0006779 porphyrin-containing compound biosynthetic process; GO:0006783 heme biosynthetic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009058 biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010638 positive regulation of organelle organization; GO:0010821 regulation of mitochondrion organization; GO:0010822 positive regulation of mitochondrion organization; GO:0016043 cellular component organization; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0022607 cellular component assembly; GO:0030097 hemopoiesis; GO:0030099 myeloid cell differentiation; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030218 erythrocyte differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032780 negative regulation of ATP-dependent activity; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033013 tetrapyrrole metabolic process; GO:0033014 tetrapyrrole biosynthetic process; GO:0033043 regulation of organelle organization; GO:0033157 regulation of intracellular protein transport; GO:0033554 cellular response to stress; GO:0034101 erythrocyte homeostasis; GO:0034641 cellular nitrogen compound metabolic process; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042127 regulation of cell population proliferation; GO:0042168 heme metabolic process; GO:0042176 regulation of protein catabolic process; GO:0042391 regulation of membrane potential; GO:0042440 pigment metabolic process; GO:0042592 homeostatic process; GO:0043086 negative regulation of catalytic activity; GO:0043462 regulation of ATP-dependent activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045732 positive regulation of protein catabolic process; GO:0045862 positive regulation of proteolysis; GO:0046148 pigment biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048534 hematopoietic or lymphoid organ development; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048872 homeostasis of number of cells; GO:0050678 regulation of epithelial cell proliferation; GO:0050680 negative regulation of epithelial cell proliferation; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051223 regulation of protein transport; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051262 protein tetramerization; GO:0051289 protein homotetramerization; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0051881 regulation of mitochondrial membrane potential; GO:0051882 mitochondrial depolarization; GO:0051899 membrane depolarization; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0062012 regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0098780 response to mitochondrial depolarisation; GO:1900542 regulation of purine nucleotide metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process; GO:1903146 regulation of autophagy of mitochondrion; GO:1903214 regulation of protein targeting to mitochondrion; GO:1903362 regulation of cellular protein catabolic process; GO:1903364 positive regulation of cellular protein catabolic process; GO:1903533 regulation of protein targeting; GO:1903578 regulation of ATP metabolic process; GO:1903599 positive regulation of autophagy of mitochondrion; GO:1903747 regulation of establishment of protein localization to mitochondrion; GO:1904923 regulation of autophagy of mitochondrion in response to mitochondrial depolarization; GO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0009986 cell surface; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0004857 enzyme inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding; GO:0019899 enzyme binding; GO:0030234 enzyme regulator activity; GO:0042030 ATPase inhibitor activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043532 angiostatin binding; GO:0046983 protein dimerization activity; GO:0051117 ATPase binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0060590 ATPase regulator activity; GO:0098772 molecular function regulator;",{"$nulls":5},"WP111 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA","http://www.wikipathways.org/instance/WP111_r117097"]
["Q9UJ41","Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3","RABGEF1",1.149021905,0.08262262,"nochange",11438.8,13299.9,13677.8,13957.1,15076.6,15107.7,0.831329285,0.966587086,0.994051448,1.014349929,1.09571101,1.097971242,"cytoplasm","K20131",null,null,"GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001960 negative regulation of cytokine-mediated signaling pathway; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002685 regulation of leukocyte migration; GO:0002686 negative regulation of leukocyte migration; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002697 regulation of immune effector process; GO:0002698 negative regulation of immune effector process; GO:0002699 positive regulation of immune effector process; GO:0002703 regulation of leukocyte mediated immunity; GO:0002704 negative regulation of leukocyte mediated immunity; GO:0002791 regulation of peptide secretion; GO:0002792 negative regulation of peptide secretion; GO:0002886 regulation of myeloid leukocyte mediated immunity; GO:0002887 negative regulation of myeloid leukocyte mediated immunity; GO:0003002 regionalization; GO:0006464 cellular protein modification process; GO:0006605 protein targeting; GO:0006612 protein targeting to membrane; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006906 vesicle fusion; GO:0006996 organelle organization; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0016567 protein ubiquitination; GO:0017157 regulation of exocytosis; GO:0018996 molting cycle"," collagen and cuticulin-based cuticle; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030100 regulation of endocytosis; GO:0030334 regulation of cell migration; GO:0030336 negative regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031347 regulation of defense response; GO:0031348 negative regulation of defense response; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032387 negative regulation of intracellular transport; GO:0032446 protein modification by small protein conjugation; GO:0032483 regulation of Rab protein signal transduction; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032675 regulation of interleukin-6 production; GO:0032715 negative regulation of interleukin-6 production; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033003 regulation of mast cell activation; GO:0033004 negative regulation of mast cell activation; GO:0033006 regulation of mast cell activation involved in immune response; GO:0033007 negative regulation of mast cell activation involved in immune response; GO:0033036 macromolecule localization; GO:0034058 endosomal vesicle fusion; GO:0034613 cellular protein localization; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035214 eye-antennal disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0036211 protein modification process; GO:0040008 regulation of growth; GO:0040012 regulation of locomotion; GO:0040013 negative regulation of locomotion; GO:0040014 regulation of multicellular organism growth; GO:0040015 negative regulation of multicellular organism growth; GO:0042303 molting cycle; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042886 amide transport; GO:0043085 positive regulation of catalytic activity; GO:0043087 regulation of GTPase activity; GO:0043170 macromolecule metabolic process; GO:0043300 regulation of leukocyte degranulation; GO:0043301 negative regulation of leukocyte degranulation; GO:0043304 regulation of mast cell degranulation; GO:0043305 negative regulation of mast cell degranulation; GO:0043412 macromolecule modification; GO:0043547 positive regulation of GTPase activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0045806 negative regulation of endocytosis; GO:0045920 negative regulation of exocytosis; GO:0045926 negative regulation of growth; GO:0045936 negative regulation of phosphate metabolic process; GO:0046578 regulation of Ras protein signal transduction; GO:0046580 negative regulation of Ras protein signal transduction; GO:0046907 intracellular transport; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048261 negative regulation of receptor-mediated endocytosis; GO:0048284 organelle fusion; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048638 regulation of developmental growth; GO:0048640 negative regulation of developmental growth; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0050708 regulation of protein secretion; GO:0050709 negative regulation of protein secretion; GO:0050727 regulation of inflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050776 regulation of immune response; GO:0050777 negative regulation of immune response; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0051036 regulation of endosome size; GO:0051046 regulation of secretion; GO:0051048 negative regulation of secretion; GO:0051049 regulation of transport; GO:0051051 negative regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051058 negative regulation of small GTPase mediated signal transduction; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051223 regulation of protein transport; GO:0051224 negative regulation of protein transport; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051271 negative regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051345 positive regulation of hydrolase activity; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0060759 regulation of response to cytokine stimulus; GO:0060761 negative regulation of response to cytokine stimulus; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070201 regulation of establishment of protein localization; GO:0070647 protein modification by small protein conjugation or removal; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072657 protein localization to membrane; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090066 regulation of anatomical structure size; GO:0090087 regulation of peptide transport; GO:0090150 establishment of protein localization to membrane; GO:0090174 organelle membrane fusion; GO:1900234 regulation of Kit signaling pathway; GO:1900235 negative regulation of Kit signaling pathway; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903305 regulation of regulated secretory pathway; GO:1903306 negative regulation of regulated secretory pathway; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1903530 regulation of secretion by cell; GO:1903531 negative regulation of secretion by cell; GO:1904950 negative regulation of establishment of protein localization; GO:2000145 regulation of cell motility; GO:2000146 negative regulation of cell motility;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005829 cytosol; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030139 endocytic vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0045177 apical part of cell; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0061630 ubiquitin protein ligase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0098772 molecular function regulator; GO:0140096 catalytic activity"," acting on a protein;","PF18151","PF18151 Domain of unknown function (DUF5601)","R","KOG3173","Predicted Zn-finger protein","WP4950 16P112 DISTAL DELETION SYNDROME","http://www.wikipathways.org/instance/WP4950_r115784",null,"R-HSA-199991 Membrane Trafficking;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8854214 TBC/RABGAPs;R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs;R-HSA-9007101 Rab regulation of trafficking","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8854214;https://reactome.org/PathwayBrowser/#/R-HSA-8876198;https://reactome.org/PathwayBrowser/#/R-HSA-9007101"]
["Q9UJY4","ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3","GGA2",0.878844434,0.018585775,"nochange",10338.5,11032.1,10376.6,9046.13,9797.57,9057.15,1.039950174,1.109719429,1.043782655,0.909950619,0.985538002,0.911059121,"cytoplasm","K12404","GGA; ADP-ribosylation factor-binding protein GGA","hsa04142 Lysosome","GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0019538 protein metabolic process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0071705 nitrogen compound transport; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding;","PF00790; PF03127; PF02883","PF00790 VHS domain; PF03127 GAT domain; PF02883 Adaptin C-terminal domain","U","KOG1086","Cytosolic sorting protein/ADP-ribosylation factor effector GGA",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-5653656 Vesicle-mediated transport;R-HSA-8854214 TBC/RABGAPs;R-HSA-9007101 Rab regulation of trafficking;R-HSA-977225 Amyloid fiber formation","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8854214;https://reactome.org/PathwayBrowser/#/R-HSA-9007101;https://reactome.org/PathwayBrowser/#/R-HSA-977225","MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["Q9UKD1","Glucocorticoid modulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=GMEB2 PE=1 SV=1","GMEB2",1.088967263,0.080099633,"nochange",13475.9,12034.7,12682.1,14323,13744.2,13523.4,1.013437649,0.905054065,0.953740946,1.07714271,1.033614804,1.017009825,"nucleus","K24505",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;",null,null,"DK","KOG4333","Nuclear DEAF-1 related transcriptional regulator (suppressin) and related SAND domain proteins",null,null,"Transcription factor"]
["Q9UKK9","ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1","NUDT5",0.924031159,0.090197897,"nochange",180336,180686,173276,159151,158869,175688,1.052538604,1.054581393,1.011332619,0.928891466,0.927245561,1.025410358,"nucleus","K13987","NUDT5; ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase [EC:3.6.1.13 3.6.1.58 2.7.7.96]","hsa00230 Purine metabolism; hsa01100 Metabolic pathways","GO:0005975 carbohydrate metabolic process; GO:0005996 monosaccharide metabolic process; GO:0006014 D-ribose metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006325 chromatin organization; GO:0006338 chromatin remodeling; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009132 nucleoside diphosphate metabolic process; GO:0009134 nucleoside diphosphate catabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009185 ribonucleoside diphosphate metabolic process; GO:0009191 ribonucleoside diphosphate catabolic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009259 ribonucleotide metabolic process; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016052 carbohydrate catabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019303 D-ribose catabolic process; GO:0019321 pentose metabolic process; GO:0019323 pentose catabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0034656 nucleobase-containing small molecule catabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0044283 small molecule biosynthetic process; GO:0046034 ATP metabolic process; GO:0046365 monosaccharide catabolic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0051276 chromosome organization; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1990966 ATP generation from poly-ADP-D-ribose;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000287 magnesium ion binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016462 pyrophosphatase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016779 nucleotidyltransferase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017110 nucleoside-diphosphatase activity; GO:0019144 ADP-sugar diphosphatase activity; GO:0030515 snoRNA binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0044715 8-oxo-dGDP phosphatase activity; GO:0046872 metal ion binding; GO:0046983 protein dimerization activity; GO:0047631 ADP-ribose diphosphatase activity; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00293","PF00293 NUDIX domain","L","KOG3041","Nucleoside diphosphate-sugar hydrolase of the MutT (NUDIX) family",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins;R-HSA-74259 Purine catabolism;R-HSA-8956319 Nucleotide catabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-2393930;https://reactome.org/PathwayBrowser/#/R-HSA-74259;https://reactome.org/PathwayBrowser/#/R-HSA-8956319"]
["Q9UKT7","F-box/LRR-repeat protein 3 OS=Homo sapiens OX=9606 GN=FBXL3 PE=1 SV=1","FBXL3",0.984159237,0.968520321,"nochange",3020.09,4382.69,3547.45,3646.39,3663.21,3467.17,0.834010218,1.210297786,0.979642841,1.006965527,1.011610439,0.95747319,"nucleus","K10269","FBXL3; F-box and leucine-rich repeat protein 3","hsa04710 Circadian rhythm","GO:0000209 protein polyubiquitination; GO:0006464 cellular protein modification process; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009314 response to radiation; GO:0009416 response to light stimulus; GO:0009605 response to external stimulus; GO:0009628 response to abiotic stimulus; GO:0009648 photoperiodism; GO:0009649 entrainment of circadian clock; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0016567 protein ubiquitination; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0030163 protein catabolic process; GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; GO:0031647 regulation of protein stability; GO:0031648 protein destabilization; GO:0032446 protein modification by small protein conjugation; GO:0036211 protein modification process; GO:0042752 regulation of circadian rhythm; GO:0043153 entrainment of circadian clock by photoperiod; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043687 post-translational protein modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0050789 regulation of biological process; GO:0050896 response to stimulus; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000151 ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016604 nuclear body; GO:0019005 SCF ubiquitin ligase complex; GO:0031461 cullin-RING ubiquitin ligase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003824 catalytic activity; GO:0004842 ubiquitin-protein transferase activity; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0140096 catalytic activity"," acting on a protein;","PF12937","PF12937 F-box-like","R","KOG1947","Leucine rich repeat proteins"," some proteins contain F-box","WP3594 CIRCADIAN RHYTHM GENES","http://www.wikipathways.org/instance/WP3594_r117682",null,"R-HSA-1280218 Adaptive Immune System;R-HSA-168256 Immune System;R-HSA-390466 Chaperonin-mediated protein folding;R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis;R-HSA-391251 Protein folding;R-HSA-392499 Metabolism of proteins;R-HSA-400253 Circadian Clock;R-HSA-597592 Post-translational protein modification;R-HSA-8951664 Neddylation;R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation;R-HSA-983169 Class I MHC mediated antigen processing & presentation","https://reactome.org/PathwayBrowser/#/R-HSA-1280218;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-390466;https://reactome.org/PathwayBrowser/#/R-HSA-390471;https://reactome.org/PathwayBrowser/#/R-HSA-391251;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-400253;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-8951664;https://reactome.org/PathwayBrowser/#/R-HSA-983168;https://reactome.org/PathwayBrowser/#/R-HSA-983169"]
["Q9UL15","BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1","BAG5",1.042050314,0.49274286,"nochange",10900.6,9851.12,11906.3,11784.4,11074.8,11172.1,0.980720751,0.886299635,1.071203005,1.060235732,0.996393426,1.005147451,"cytoplasm","K09559",null,null,"GO:0006457 protein folding; GO:0006996 organelle organization; GO:0007030 Golgi organization; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008219 cell death; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010941 regulation of cell death; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031396 regulation of protein ubiquitination; GO:0031397 negative regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031647 regulation of protein stability; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043086 negative regulation of catalytic activity; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045861 negative regulation of proteolysis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051340 regulation of ligase activity; GO:0051348 negative regulation of transferase activity; GO:0051352 negative regulation of ligase activity; GO:0051438 regulation of ubiquitin-protein transferase activity; GO:0051444 negative regulation of ubiquitin-protein transferase activity; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0061083 regulation of protein refolding; GO:0061084 negative regulation of protein refolding; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070997 neuron death; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090083 regulation of inclusion body assembly; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1900034 regulation of cellular response to heat; GO:1900407 regulation of cellular response to oxidative stress; GO:1900408 negative regulation of cellular response to oxidative stress; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902882 regulation of response to oxidative stress; GO:1902883 negative regulation of response to oxidative stress; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903201 regulation of oxidative stress-induced cell death; GO:1903202 negative regulation of oxidative stress-induced cell death; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903321 negative regulation of protein modification by small protein conjugation or removal; GO:1903332 regulation of protein folding; GO:1903333 negative regulation of protein folding; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:2000026 regulation of multicellular organismal development; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0016234 inclusion body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm;","GO:0000166 nucleotide binding; GO:0000774 adenyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0017076 purine nucleotide binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030234 enzyme regulator activity; GO:0030554 adenyl nucleotide binding; GO:0031625 ubiquitin protein ligase binding; GO:0036094 small molecule binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0051087 chaperone binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0060590 ATPase regulator activity; GO:0097159 organic cyclic compound binding; GO:0098772 molecular function regulator; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"T","KOG4361","BCL2-associated athanogene-like proteins and related BAG family chaperone regulators",{"$nulls":3},"R-HSA-2262752 Cellular responses to stress;R-HSA-3371453 Regulation of HSF1-mediated heat shock response;R-HSA-3371556 Cellular response to heat stress;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3371453;https://reactome.org/PathwayBrowser/#/R-HSA-3371556;https://reactome.org/PathwayBrowser/#/R-HSA-8953897"]
["Q9ULJ3","Zinc finger and BTB domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZBTB21 PE=1 SV=2","ZBTB21",1.641985022,0.134467568,"nochange",469.612,832.517,591.694,1438.49,729.781,941.358,0.563145604,0.998331152,0.709542932,1.724997062,0.875133008,1.128850242,"nucleus","K24805",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000166 nucleotide binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0008327 methyl-CpG binding; GO:0036094 small molecule binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00651; PF00096; PF18450","PF00651 BTB/POZ domain; PF00096 Zinc finger"," C2H2 type; PF18450 Zinc Finger domain","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["Q9ULX6","A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4","AKAP8L",1.249954333,0.007954076,"up",23507.9,22674.4,23342.8,26499.2,30319.9,30084.1,0.901674441,0.869704523,0.895341828,1.016409435,1.162957086,1.153912687,"nucleus","K15978",null,null,"GO:0000070 mitotic sister chromatid segregation; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000819 sister chromatid segregation; GO:0001932 regulation of protein phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006323 DNA packaging; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006998 nuclear envelope organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007076 mitotic chromosome condensation; GO:0008152 metabolic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010638 positive regulation of organelle organization; GO:0010793 regulation of mRNA export from nucleus; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0030261 chromosome condensation; GO:0030397 membrane disassembly; GO:0031056 regulation of histone modification; GO:0031058 positive regulation of histone modification; GO:0031063 regulation of histone deacetylation; GO:0031065 positive regulation of histone deacetylation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032239 regulation of nucleobase-containing compound transport; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0033043 regulation of organelle organization; GO:0033044 regulation of chromosome organization; GO:0033127 regulation of histone phosphorylation; GO:0033157 regulation of intracellular protein transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0042325 regulation of phosphorylation; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044770 cell cycle phase transition; GO:0044839 cell cycle G2/M phase transition; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0046822 regulation of nucleocytoplasmic transport; GO:0046825 regulation of protein export from nucleus; GO:0046831 regulation of RNA export from nucleus; GO:0048285 organelle fission; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051081 nuclear membrane disassembly; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051223 regulation of protein transport; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0060255 regulation of macromolecule metabolic process; GO:0060341 regulation of cellular localization; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0071103 DNA conformation change; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090087 regulation of peptide transport; GO:0090304 nucleic acid metabolic process; GO:0090311 regulation of protein deacetylation; GO:0090312 positive regulation of protein deacetylation; GO:0098813 nuclear chromosome segregation; GO:0140014 mitotic nuclear division; GO:1901360 organic cyclic compound metabolic process; GO:1902275 regulation of chromatin organization; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903047 mitotic cell cycle process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:1905269 positive regulation of chromatin organization; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000197 regulation of ribonucleoprotein complex localization; GO:2001141 regulation of RNA biosynthetic process; GO:2001252 positive regulation of chromosome organization;","GO:0000785 chromatin; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005737 cytoplasm; GO:0016363 nuclear matrix; GO:0016604 nuclear body; GO:0016607 nuclear speck; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0034399 nuclear periphery; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding; GO:0005521 lamin binding; GO:0017151 DEAD/H-box RNA helicase binding; GO:0019899 enzyme binding; GO:0034237 protein kinase A regulatory subunit binding; GO:0042826 histone deacetylase binding; GO:0051018 protein kinase A binding;"]
["Q9UMR5","Lysosomal thioesterase PPT2 OS=Homo sapiens OX=9606 GN=PPT2 PE=1 SV=4","PPT2",0.942726476,0.297710962,"nochange",25989.3,23943.6,28150.3,24301.8,24337.9,24971.4,1.02796084,0.947046791,1.113435376,0.961214759,0.962642631,0.987699604,"extracellular","K01074","PPT; palmitoyl-protein thioesterase [EC:3.1.2.22]","hsa00062 Fatty acid elongation; hsa04142 Lysosome; hsa01212 Fatty acid metabolism; hsa01100 Metabolic pathways","GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035337 fatty-acyl-CoA metabolic process; GO:0035383 thioester metabolic process; GO:0035384 thioester biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046949 fatty-acyl-CoA biosynthetic process; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0071616 acyl-CoA biosynthetic process; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:0098732 macromolecule deacylation; GO:0098734 macromolecule depalmitoylation; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901568 fatty acid derivative metabolic process; GO:1901570 fatty acid derivative biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000323 lytic vacuole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0031974 membrane-enclosed lumen; GO:0043202 lysosomal lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016790 thiolester hydrolase activity; GO:0098599 palmitoyl hydrolase activity;","PF02089","PF02089 Palmitoyl protein thioesterase","IO","KOG2541","Palmitoyl protein thioesterase","WP4754 IL18 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4754_r115147",null,"R-HSA-1430728 Metabolism;R-HSA-556833 Metabolism of lipids;R-HSA-75105 Fatty acyl-CoA biosynthesis;R-HSA-8978868 Fatty acid metabolism","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-75105;https://reactome.org/PathwayBrowser/#/R-HSA-8978868"]
["Q9UNF1","Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2","MAGED2",1.775769032,{"v":6.28012e-05,"d":"6.28E-05"},"up",31770.4,29117.5,30789,53503.9,56496,52797.1,0.749084287,0.686534061,0.725944783,1.261517979,1.332065882,1.244853009,"nucleus","K24127",null,null,"GO:0000003 reproduction; GO:0002576 platelet degranulation; GO:0003008 system process; GO:0003014 renal system process; GO:0003096 renal sodium ion transport; GO:0006139 nucleobase-containing compound metabolic process; GO:0006259 DNA metabolic process; GO:0006281 DNA repair; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006814 sodium ion transport; GO:0006887 exocytosis; GO:0006950 response to stress; GO:0006974 cellular response to DNA damage stimulus; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007406 negative regulation of neuroblast proliferation; GO:0007565 female pregnancy; GO:0008152 metabolic process; GO:0008285 negative regulation of cell population proliferation; GO:0009410 response to xenobiotic stimulus; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010243 response to organonitrogen compound; GO:0010721 negative regulation of cell development; GO:0010941 regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0014074 response to purine-containing compound; GO:0016192 vesicle-mediated transport; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0030001 metal ion transport; GO:0030154 cell differentiation; GO:0031000 response to caffeine; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032940 secretion by cell; GO:0033554 cellular response to stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0036270 response to diuretic; GO:0042127 regulation of cell population proliferation; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0043279 response to alkaloid; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044703 multi-organism reproductive process; GO:0044706 multi-multicellular organism process; GO:0045055 regulated exocytosis; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0046483 heterocycle metabolic process; GO:0046903 secretion; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051093 negative regulation of developmental process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060284 regulation of cell development; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070293 renal absorption; GO:0070294 renal sodium ion absorption; GO:0071704 organic substance metabolic process; GO:0072091 regulation of stem cell proliferation; GO:0090304 nucleic acid metabolic process; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1901360 organic cyclic compound metabolic process; GO:1901698 response to nitrogen compound; GO:1902692 regulation of neuroblast proliferation; GO:2000026 regulation of multicellular organismal development; GO:2000177 regulation of neural precursor cell proliferation; GO:2000178 negative regulation of neural precursor cell proliferation; GO:2000647 negative regulation of stem cell proliferation;","GO:0000793 condensed chromosome; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005694 chromosome; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0030915 Smc5-Smc6 complex; GO:0031091 platelet alpha granule; GO:0031093 platelet alpha granule lumen; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034774 secretory granule lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0106068 SUMO ligase complex; GO:1902494 catalytic complex; GO:1990234 transferase complex;",{"$nulls":3},"S","KOG4562","Uncharacterized conserved protein (tumor-rejection antigen MAGE in humans)",{"$nulls":3},"R-HSA-109582 Hemostasis;R-HSA-114608 Platelet degranulation ;R-HSA-76002 Platelet activation"," signaling and aggregation;R-HSA-76005 Response to elevated platelet cytosolic Ca2+","https://reactome.org/PathwayBrowser/#/R-HSA-109582;https://reactome.org/PathwayBrowser/#/R-HSA-114608;https://reactome.org/PathwayBrowser/#/R-HSA-76002;https://reactome.org/PathwayBrowser/#/R-HSA-76005"]
["Q9UNQ2","Probable dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1","DIMT1",0.461035246,3.32469E-4,"down",19607.3,15796,18083.5,8440.93,8381.87,7836.5,1.505434052,1.212805246,1.388437811,0.648088388,0.643553805,0.601680698,"cytoplasm","K14191",null,null,"GO:0000154 rRNA modification; GO:0001510 RNA methylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0031167 rRNA methylation; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0032259 methylation; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043414 macromolecule methylation; GO:0044085 cellular component biogenesis; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090069 regulation of ribosome biogenesis; GO:0090070 positive regulation of ribosome biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:2000232 regulation of rRNA processing; GO:2000234 positive regulation of rRNA processing;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005759 mitochondrial matrix; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000179 rRNA (adenine-N6","N6-)-dimethyltransferase activity; GO:0003824 catalytic activity; GO:0008168 methyltransferase activity; GO:0008170 N-methyltransferase activity; GO:0008173 RNA methyltransferase activity; GO:0008649 rRNA methyltransferase activity; GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; GO:0016433 rRNA (adenine) methyltransferase activity; GO:0016740 transferase activity; GO:0016741 transferase activity"," transferring one-carbon groups; GO:0140098 catalytic activity"," acting on RNA; GO:0140102 catalytic activity"," acting on a rRNA;","PF00398","PF00398 Ribosomal RNA adenine dimethylase","A","KOG0820","Ribosomal RNA adenine dimethylase",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9UPN7","Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5","PPP6R1",1.000238859,0.975899629,"nochange",21627.9,22364.4,21318.3,20768.1,23702.7,20855.4,0.993344907,1.027171517,0.979125331,0.953855269,1.088638117,0.957864859,"nucleus","K15499",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007275 multicellular organism development; GO:0009790 embryo development; GO:0009987 cellular process; GO:0010921 regulation of phosphatase activity; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022607 cellular component assembly; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030588 pseudocleavage; GO:0030590 first cell cycle pseudocleavage; GO:0030865 cortical cytoskeleton organization; GO:0030866 cortical actin cytoskeleton organization; GO:0031323 regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0040001 establishment of mitotic spindle localization; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051293 establishment of spindle localization; GO:0051336 regulation of hydrolase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051653 spindle localization; GO:0051656 establishment of organelle localization; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090114 COPII-coated vesicle budding; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903047 mitotic cell cycle process;","GO:0000235 astral microtubule; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005818 aster; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005874 microtubule; GO:0005876 spindle microtubule; GO:0005881 cytoplasmic microtubule; GO:0005938 cell cortex; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0071944 cell periphery; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding;",null,null,"D","KOG2073","SAP family cell cycle dependent phosphatase-associated protein",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-204005 COPII-mediated vesicle transport;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-204005;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["Q9UPT6","C-Jun-amino-terminal kinase-interacting protein 3 OS=Homo sapiens OX=9606 GN=MAPK8IP3 PE=1 SV=3","MAPK8IP3",0.91418918,0.545850056,"nochange",1928.95,2327.15,2788,1997.45,2447.37,1994.82,0.85834494,1.035536135,1.240605351,0.888826097,1.089031678,0.887655799,"nucleus","K04436","MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3","hsa04010 MAPK signaling pathway","GO:0000003 reproduction; GO:0000165 MAPK cascade; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001701 in utero embryonic development; GO:0001932 regulation of protein phosphorylation; GO:0001934 positive regulation of protein phosphorylation; GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006935 chemotaxis; GO:0006950 response to stress; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007254 JNK cascade; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007411 axon guidance; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007585 respiratory gaseous exchange by respiratory system; GO:0007588 excretion; GO:0007610 behavior; GO:0008088 axo-dendritic transport; GO:0008104 protein localization; GO:0008152 metabolic process; GO:0009605 response to external stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009791 post-embryonic development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009887 animal organ morphogenesis; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010562 positive regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010720 positive regulation of cell development; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016310 phosphorylation; GO:0016482 cytosolic transport; GO:0018991 oviposition; GO:0019098 reproductive behavior; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0030334 regulation of cell migration; GO:0030335 positive regulation of cell migration; GO:0030421 defecation; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0030900 forebrain development; GO:0031098 stress-activated protein kinase signaling cascade; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032147 activation of protein kinase activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032874 positive regulation of stress-activated MAPK cascade; GO:0032879 regulation of localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0033036 macromolecule localization; GO:0033554 cellular response to stress; GO:0033674 positive regulation of kinase activity; GO:0035295 tube development; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0040017 positive regulation of locomotion; GO:0042147 retrograde transport"," endosome to Golgi; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042327 positive regulation of phosphorylation; GO:0042330 taxis; GO:0043009 chordate embryonic development; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043405 regulation of MAP kinase activity; GO:0043406 positive regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043410 positive regulation of MAPK cascade; GO:0043412 macromolecule modification; GO:0043506 regulation of JUN kinase activity; GO:0043507 positive regulation of JUN kinase activity; GO:0043549 regulation of kinase activity; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045859 regulation of protein kinase activity; GO:0045860 positive regulation of protein kinase activity; GO:0045937 positive regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046330 positive regulation of JNK cascade; GO:0046907 intracellular transport; GO:0048286 lung alveolus development; GO:0048468 cell development; GO:0048489 synaptic vesicle transport; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051147 regulation of muscle cell differentiation; GO:0051149 positive regulation of muscle cell differentiation; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051272 positive regulation of cellular component movement; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051403 stress-activated MAPK cascade; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060322 head development; GO:0060425 lung morphogenesis; GO:0060541 respiratory system development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070304 positive regulation of stress-activated protein kinase signaling cascade; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071902 positive regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0097479 synaptic vesicle localization; GO:0097480 establishment of synaptic vesicle localization; GO:0097485 neuron projection guidance; GO:0099003 vesicle-mediated transport in synapse; GO:0099111 microtubule-based transport; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901564 organonitrogen compound metabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2000147 positive regulation of cell motility;","GO:0000139 Golgi membrane; GO:0001669 acrosomal vesicle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005790 smooth endoplasmic reticulum; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005815 microtubule organizing center; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030140 trans-Golgi network transport vesicle; GO:0030141 secretory granule; GO:0030424 axon; GO:0030425 dendrite; GO:0030673 axolemma; GO:0031090 organelle membrane; GO:0031252 cell leading edge; GO:0031253 cell projection membrane; GO:0031256 leading edge membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032589 neuron projection membrane; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043194 axon initial segment; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044304 main axon; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region; GO:0098791 Golgi apparatus subcompartment; GO:0098793 presynapse; GO:0099503 secretory vesicle; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0005078 MAP-kinase scaffold activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0008432 JUN kinase binding; GO:0019894 kinesin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0030159 signaling receptor complex adaptor activity; GO:0031434 mitogen-activated protein kinase kinase binding; GO:0031435 mitogen-activated protein kinase kinase kinase binding; GO:0035591 signaling adaptor activity; GO:0060090 molecular adaptor activity;",null,null,"T","KOG2077","JNK/SAPK-associated protein-1","WP382 MAPK SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP382_r119087"]
["Q9UQR0","Sex comb on midleg-like protein 2 OS=Homo sapiens OX=9606 GN=SCML2 PE=1 SV=1","SCML2",1.407844466,1.96394E-3,"up",5482.11,5111.22,5783.82,7964.48,7215.64,7876.36,0.834127114,0.777694572,0.880033616,1.211830613,1.097891318,1.198422768,"nucleus","K11465",null,null,"GO:0000003 reproduction; GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001654 eye development; GO:0002009 morphogenesis of an epithelium; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007293 germarium-derived egg chamber formation; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007423 sensory organ development; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0016333 morphogenesis of follicular epithelium; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0022008 neurogenesis; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030707 ovarian follicle cell development; GO:0030708 germarium-derived female germ-line cyst encapsulation; GO:0030713 ovarian follicle cell stalk formation; GO:0030855 epithelial cell differentiation; GO:0031175 neuron projection development; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0040008 regulation of growth; GO:0044703 multi-organism reproductive process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045926 negative regulation of growth; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048138 germ-line cyst encapsulation; GO:0048139 female germ-line cyst encapsulation; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048749 compound eye development; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0061564 axon development; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0000151 ubiquitin ligase complex; GO:0000152 nuclear ubiquitin ligase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0031519 PcG protein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035102 PRC1 complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF02820; PF12140; PF00536","PF02820 mbt repeat; PF12140 SLED domain; PF00536 SAM domain (Sterile alpha motif)","K","KOG3766","Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans)",null,null,"Transcription factor"]
["Q9Y228","TRAF3-interacting JNK-activating modulator OS=Homo sapiens OX=9606 GN=TRAF3IP3 PE=1 SV=2","TRAF3IP3",0.79218422,0.054583505,"nochange",6866.94,8761.93,7549.11,6521.67,6274.67,5564.89,0.991873461,1.265589307,1.090407352,0.942002027,0.906324892,0.803802961,"peroxisome",{"$nulls":11},"WP2849 HEMATOPOIETIC STEM CELL DIFFERENTIATION","http://www.wikipathways.org/instance/WP2849_r117150"]
["Q9Y287","Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1","ITM2B",1.714115387,0.002782364,"up",2930.88,2570.95,2826.67,5444.64,4300.9,4530.47,0.777954488,0.682416916,0.750293636,1.445191247,1.141604043,1.20253967,"cytoplasm","K18264",null,null,"GO:0006807 nitrogen compound metabolic process; GO:0006915 apoptotic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008219 cell death; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010561 negative regulation of glycoprotein biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0012501 programmed cell death; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0038034 signal transduction in absence of ligand; GO:0042984 regulation of amyloid precursor protein biosynthetic process; GO:0042985 negative regulation of amyloid precursor protein biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0097190 apoptotic signaling pathway; GO:0097191 extrinsic apoptotic signaling pathway; GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand; GO:1901564 organonitrogen compound metabolic process; GO:1903018 regulation of glycoprotein metabolic process; GO:1903019 negative regulation of glycoprotein metabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0070062 extracellular exosome; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:1903561 extracellular vesicle;","GO:0000166 nucleotide binding; GO:0001540 amyloid-beta binding; GO:0005488 binding; GO:0005524 ATP binding; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0033218 amide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0042277 peptide binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF04089","PF04089 BRICHOS domain","S","KOG4681","Uncharacterized conserved protein",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-977225 Amyloid fiber formation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-977225"]
["Q9Y2G5","GDP-fucose protein O-fucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POFUT2 PE=1 SV=3","POFUT2",2.160204121,0.00173143,"up",5526.45,5029.79,4822.89,13159.3,9601.16,10461.6,0.682261072,0.620946524,0.59540394,1.62456516,1.185299372,1.291523932,"extracellular","K03691","POFUT; peptide-O-fucosyltransferase [EC:2.4.1.221]","hsa00514 Other types of O-glycan biosynthesis","GO:0001704 formation of primary germ layer; GO:0001707 mesoderm formation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006493 protein O-linked glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007369 gastrulation; GO:0007498 mesoderm development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010717 regulation of epithelial to mesenchymal transition; GO:0016266 O-glycan processing; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0034645 cellular macromolecule biosynthetic process; GO:0036065 fucosylation; GO:0036066 protein O-linked fucosylation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0048332 mesoderm morphogenesis; GO:0048598 embryonic morphogenesis; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070085 glycosylation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031984 organelle subcompartment; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098827 endoplasmic reticulum subcompartment;","GO:0003824 catalytic activity; GO:0008417 fucosyltransferase activity; GO:0016740 transferase activity; GO:0016757 glycosyltransferase activity; GO:0016758 hexosyltransferase activity; GO:0046922 peptide-O-fucosyltransferase activity; GO:0140096 catalytic activity"," acting on a protein;",{"$nulls":8},"R-HSA-392499 Metabolism of proteins;R-HSA-5173105 O-linked glycosylation;R-HSA-5173214 O-glycosylation of TSR domain-containing proteins;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5173105;https://reactome.org/PathwayBrowser/#/R-HSA-5173214;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q9Y2H2","Phosphatidylinositide phosphatase SAC2 OS=Homo sapiens OX=9606 GN=INPP5F PE=1 SV=3","INPP5F",0.534433332,0.070719634,"nochange",2333.57,3745.62,1999.61,1623.87,1006.19,1687.52,1.129476508,1.812926032,0.967835771,0.785973002,0.487008304,0.816780383,"nucleus","K21798","SAC2; phosphatidylinositol 4-phosphatase [EC:3.1.3.-]","hsa04070 Phosphatidylinositol signaling system; hsa00562 Inositol phosphate metabolism; hsa01100 Metabolic pathways","GO:0001919 regulation of receptor recycling; GO:0001921 positive regulation of receptor recycling; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0003008 system process; GO:0003012 muscle system process; GO:0003299 muscle hypertrophy in response to stress; GO:0003300 cardiac muscle hypertrophy; GO:0006629 lipid metabolic process; GO:0006644 phospholipid metabolic process; GO:0006650 glycerophospholipid metabolic process; GO:0006661 phosphatidylinositol biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006810 transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007626 locomotory behavior; GO:0008152 metabolic process; GO:0008344 adult locomotory behavior; GO:0008610 lipid biosynthetic process; GO:0008654 phospholipid biosynthetic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009395 phospholipid catabolic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010721 negative regulation of cell development; GO:0010975 regulation of neuron projection development; GO:0010977 negative regulation of neuron projection development; GO:0014887 cardiac muscle adaptation; GO:0014888 striated muscle adaptation; GO:0014896 muscle hypertrophy; GO:0014897 striated muscle hypertrophy; GO:0014898 cardiac muscle hypertrophy in response to stress; GO:0016042 lipid catabolic process; GO:0016192 vesicle-mediated transport; GO:0016311 dephosphorylation; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019637 organophosphate metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030258 lipid modification; GO:0030534 adult behavior; GO:0031161 phosphatidylinositol catabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031345 negative regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032101 regulation of response to external stimulus; GO:0032102 negative regulation of response to external stimulus; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032386 regulation of intracellular transport; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0033135 regulation of peptidyl-serine phosphorylation; GO:0033137 negative regulation of peptidyl-serine phosphorylation; GO:0035556 intracellular signal transduction; GO:0040012 regulation of locomotion; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042509 regulation of tyrosine phosphorylation of STAT protein; GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein; GO:0043500 muscle adaptation; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044255 cellular lipid metabolic process; GO:0045017 glycerolipid biosynthetic process; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045665 negative regulation of neuron differentiation; GO:0045936 negative regulation of phosphate metabolic process; GO:0046425 regulation of receptor signaling pathway via JAK-STAT; GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT; GO:0046434 organophosphate catabolic process; GO:0046474 glycerophospholipid biosynthetic process; GO:0046475 glycerophospholipid catabolic process; GO:0046486 glycerolipid metabolic process; GO:0046488 phosphatidylinositol metabolic process; GO:0046503 glycerolipid catabolic process; GO:0046839 phospholipid dephosphorylation; GO:0046856 phosphatidylinositol dephosphorylation; GO:0048015 phosphatidylinositol-mediated signaling; GO:0048017 inositol lipid-mediated signaling; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048679 regulation of axon regeneration; GO:0048681 negative regulation of axon regeneration; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050730 regulation of peptidyl-tyrosine phosphorylation; GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051093 negative regulation of developmental process; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051270 regulation of cellular component movement; GO:0051716 cellular response to stimulus; GO:0051896 regulation of protein kinase B signaling; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0070570 regulation of neuron projection regeneration; GO:0070571 negative regulation of neuron projection regeneration; GO:0071704 organic substance metabolic process; GO:0072583 clathrin-dependent endocytosis; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090407 organophosphate biosynthetic process; GO:0098657 import into cell; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903034 regulation of response to wounding; GO:1903035 negative regulation of response to wounding; GO:1904892 regulation of receptor signaling pathway via STAT; GO:1904893 negative regulation of receptor signaling pathway via STAT; GO:2000026 regulation of multicellular organismal development; GO:2000145 regulation of cell motility; GO:2001135 regulation of endocytic recycling;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005769 early endosome; GO:0010008 endosome membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030139 endocytic vesicle; GO:0030424 axon; GO:0030425 dendrite; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031901 early endosome membrane; GO:0031982 vesicle; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0044297 cell body; GO:0045334 clathrin-coated endocytic vesicle; GO:0055037 recycling endosome; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0120025 plasma membrane bounded cell projection;","GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity; GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity; GO:0042578 phosphoric ester hydrolase activity; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0046983 protein dimerization activity; GO:0052745 inositol phosphate phosphatase activity; GO:0052833 inositol monophosphate 4-phosphatase activity; GO:0052834 inositol monophosphate phosphatase activity; GO:0052866 phosphatidylinositol phosphate phosphatase activity;","PF12456","PF12456 Inositol phosphatase ","I","KOG1890","Phosphoinositide phosphatase SAC1",{"$nulls":3},"R-HSA-1430728 Metabolism;R-HSA-1483255 PI Metabolism;R-HSA-1483257 Phospholipid metabolism;R-HSA-1660516 Synthesis of PIPs at the early endosome membrane;R-HSA-556833 Metabolism of lipids","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1483255;https://reactome.org/PathwayBrowser/#/R-HSA-1483257;https://reactome.org/PathwayBrowser/#/R-HSA-1660516;https://reactome.org/PathwayBrowser/#/R-HSA-556833","ESTROGEN RESPONSE EARLY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY"]
["Q9Y2U8","Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2","LEMD3",1.549949188,0.000639372,"up",11603,11775.3,11849.5,19357.8,18578.2,16665.3,0.775004982,0.786513502,0.791469579,1.292975216,1.240903004,1.113133717,"plasma membrane","K19410",null,null,"GO:0000003 reproduction; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0000281 mitotic cytokinesis; GO:0000910 cytokinesis; GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001667 ameboidal-type cell migration; GO:0001944 vasculature development; GO:0002041 intussusceptive angiogenesis; GO:0002044 blood vessel endothelial cell migration involved in intussusceptive angiogenesis; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0006997 nucleus organization; GO:0006998 nuclear envelope organization; GO:0007049 cell cycle; GO:0007059 chromosome segregation; GO:0007127 meiosis I; GO:0007275 multicellular organism development; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0009314 response to radiation; GO:0009628 response to abiotic stimulus; GO:0009653 anatomical structure morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010165 response to X-ray; GO:0010212 response to ionizing radiation; GO:0010256 endomembrane system organization; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010631 epithelial cell migration; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0014706 striated muscle tissue development; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022402 cell cycle process; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0030154 cell differentiation; GO:0030510 regulation of BMP signaling pathway; GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway; GO:0030514 negative regulation of BMP signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032925 regulation of activin receptor signaling pathway; GO:0032926 negative regulation of activin receptor signaling pathway; GO:0034397 telomere localization; GO:0034398 telomere tethering at nuclear periphery; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0035914 skeletal muscle cell differentiation; GO:0040011 locomotion; GO:0043534 blood vessel endothelial cell migration; GO:0043542 endothelial cell migration; GO:0044821 meiotic telomere tethering at nuclear periphery; GO:0045132 meiotic chromosome segregation; GO:0045141 meiotic telomere clustering; GO:0045143 homologous chromosome segregation; GO:0048285 organelle fission; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050000 chromosome localization; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051128 regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051252 regulation of RNA metabolic process; GO:0051276 chromosome organization; GO:0051301 cell division; GO:0051303 establishment of chromosome localization; GO:0051321 meiotic cell cycle; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051656 establishment of organelle localization; GO:0051674 localization of cell; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060537 muscle tissue development; GO:0060538 skeletal muscle organ development; GO:0061024 membrane organization; GO:0061061 muscle structure development; GO:0061640 cytoskeleton-dependent cytokinesis; GO:0061982 meiosis I cell cycle process; GO:0065007 biological regulation; GO:0070192 chromosome organization involved in meiotic cell cycle; GO:0070197 meiotic attachment of telomere to nuclear envelope; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090288 negative regulation of cellular response to growth factor stimulus; GO:0097240 chromosome attachment to the nuclear envelope; GO:0098813 nuclear chromosome segregation; GO:0140013 meiotic nuclear division; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903053 regulation of extracellular matrix organization; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005637 nuclear inner membrane; GO:0005639 integral component of nuclear inner membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031229 intrinsic component of nuclear inner membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0005521 lamin binding; GO:0031490 chromatin DNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF03020; PF09402","PF03020 LEM domain; PF09402 Man1-Src1p-C-terminal domain","K","KOG0147","Transcriptional coactivator CAPER (RRM superfamily)","WP4535 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY;WP4879 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES","http://www.wikipathways.org/instance/WP4535_r109210;http://www.wikipathways.org/instance/WP4879_r120399",null,"R-HSA-162582 Signal Transduction;R-HSA-1640170 Cell Cycle;R-HSA-194315 Signaling by Rho GTPases;R-HSA-2555396 Mitotic Metaphase and Anaphase;R-HSA-2980766 Nuclear Envelope Breakdown;R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation;R-HSA-2995410 Nuclear Envelope (NE) Reassembly;R-HSA-4419969 Depolymerisation of the Nuclear Lamina;R-HSA-68875 Mitotic Prophase;R-HSA-68882 Mitotic Anaphase;R-HSA-68886 M Phase;R-HSA-69278 Cell Cycle"," Mitotic;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9013405 RHOD GTPase cycle;R-HSA-9013408 RHOG GTPase cycle;R-HSA-9013423 RAC3 GTPase cycle;R-HSA-9696264 RND3 GTPase cycle;R-HSA-9696270 RND2 GTPase cycle;R-HSA-9696273 RND1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-1640170;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-2555396;https://reactome.org/PathwayBrowser/#/R-HSA-2980766;https://reactome.org/PathwayBrowser/#/R-HSA-2995383;https://reactome.org/PathwayBrowser/#/R-HSA-2995410;https://reactome.org/PathwayBrowser/#/R-HSA-4419969;https://reactome.org/PathwayBrowser/#/R-HSA-68875;https://reactome.org/PathwayBrowser/#/R-HSA-68882;https://reactome.org/PathwayBrowser/#/R-HSA-68886;https://reactome.org/PathwayBrowser/#/R-HSA-69278;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9013405;https://reactome.org/PathwayBrowser/#/R-HSA-9013408;https://reactome.org/PathwayBrowser/#/R-HSA-9013423;https://reactome.org/PathwayBrowser/#/R-HSA-9696264;https://reactome.org/PathwayBrowser/#/R-HSA-9696270;https://reactome.org/PathwayBrowser/#/R-HSA-9696273;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q9Y2X0","Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2","MED16",0.906313274,0.168564639,"nochange",7630.18,7032.96,7902.49,7052.58,7216.32,6182.63,1.064251568,0.980951788,1.102233155,0.98368837,1.006526698,0.862348421,"nucleus","K15159","MED16; mediator of RNA polymerase II transcription subunit 16","hsa04919 Thyroid hormone signaling pathway","GO:0002237 response to molecule of bacterial origin; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006352 DNA-templated transcription"," initiation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006367 transcription initiation from RNA polymerase II promoter; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009628 response to abiotic stimulus; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0014070 response to organic cyclic compound; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023052 signaling; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030521 androgen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032496 response to lipopolysaccharide; GO:0032774 RNA biosynthetic process; GO:0032870 cellular response to hormone stimulus; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043401 steroid hormone mediated signaling pathway; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048545 response to steroid hormone; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901700 response to oxygen-containing compound; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0016592 mediator complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003712 transcription coregulator activity; GO:0003713 transcription coactivator activity; GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008134 transcription factor binding; GO:0030374 nuclear receptor coactivator activity; GO:0038023 signaling receptor activity; GO:0042809 vitamin D receptor binding; GO:0046966 thyroid hormone receptor binding; GO:0051427 hormone receptor binding; GO:0060089 molecular transducer activity; GO:0140110 transcription regulator activity;",{"$nulls":7},"Transcription factor","R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-1989781 PPARA activates gene expression;R-HSA-212436 Generic Transcription Pathway;R-HSA-381340 Transcriptional regulation of white adipocyte differentiation;R-HSA-400206 Regulation of lipid metabolism by PPARalpha;R-HSA-556833 Metabolism of lipids;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-1989781;https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-381340;https://reactome.org/PathwayBrowser/#/R-HSA-400206;https://reactome.org/PathwayBrowser/#/R-HSA-556833;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["Q9Y333","U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1","LSM2",1.226239943,0.024000931,"nochange",57870.1,63865.4,53034.7,68234.2,73111.3,72964.7,0.892413496,0.984866881,0.817846903,1.052238046,1.127447695,1.125186979,"cytoplasm","K12621","LSM2; U6 snRNA-associated Sm-like protein LSm2","hsa03040 Spliceosome; hsa03018 RNA degradation","GO:0000244 spliceosomal tri-snRNP complex assembly; GO:0000288 nuclear-transcribed mRNA catabolic process"," deadenylation-dependent decay; GO:0000291 nuclear-transcribed mRNA catabolic process"," exonucleolytic; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0000956 nuclear-transcribed mRNA catabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006401 RNA catabolic process; GO:0006402 mRNA catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019222 regulation of metabolic process; GO:0019439 aromatic compound catabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0043170 macromolecule metabolic process; GO:0043928 exonucleolytic catabolism of deadenylated mRNA; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048519 negative regulation of biological process; GO:0050789 regulation of biological process; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000932 P-body; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005688 U6 snRNP; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030532 small nuclear ribonucleoprotein complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0035770 ribonucleoprotein granule; GO:0036464 cytoplasmic ribonucleoprotein granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0046540 U4/U6 x U5 tri-snRNP complex; GO:0070013 intracellular organelle lumen; GO:0071011 precatalytic spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:0097525 spliceosomal snRNP complex; GO:0097526 spliceosomal tri-snRNP complex; GO:0120114 Sm-like protein family complex; GO:1902494 catalytic complex; GO:1990726 Lsm1-7-Pat1 complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0017069 snRNA binding; GO:0017070 U6 snRNA binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF01423","PF01423 LSM domain ","A","KOG3448","Predicted snRNP core protein","WP411 MRNA PROCESSING","http://www.wikipathways.org/instance/WP411_r117160",null,"R-HSA-429914 Deadenylation-dependent mRNA decay;R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease;R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-429914;https://reactome.org/PathwayBrowser/#/R-HSA-430039;https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","MYC TARGETS V1","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V1"]
["Q9Y3C0","WASH complex subunit 3 OS=Homo sapiens OX=9606 GN=WASHC3 PE=1 SV=1","WASHC3",0.933902404,0.604315144,"nochange",9531.74,9469.68,7224.95,7072.1,9038.08,8382.69,1.127588663,1.12024707,0.854699321,0.836617426,1.069189523,0.991657998,"cytoskeleton","K18463","CCDC53; WASH complex subunit CCDC53","hsa04144 Endocytosis","GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008104 protein localization; GO:0008340 determination of adult lifespan; GO:0010259 multicellular organism aging; GO:0030155 regulation of cell adhesion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0045185 maintenance of protein location; GO:0045785 positive regulation of cell adhesion; GO:0048518 positive regulation of biological process; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0051098 regulation of binding; GO:0051101 regulation of DNA binding; GO:0051179 localization; GO:0051220 cytoplasmic sequestering of protein; GO:0051235 maintenance of location; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:2000677 regulation of transcription regulatory region DNA binding;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0032991 protein-containing complex; GO:0071203 WASH complex;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"S","KOG4496","Predicted coiled-coil protein"]
["Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1","PPIL1",1.291610211,1.75522E-4,"up",63658,65786.5,64883.4,86386.6,82726.5,81882.8,0.857686025,0.886364034,0.874196259,1.163916234,1.114602453,1.103234994,"cytoplasm","K12733","PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]","hsa03040 Spliceosome","GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0000413 protein peptidyl-prolyl isomerization; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006464 cellular protein modification process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0018193 peptidyl-amino acid modification; GO:0018208 peptidyl-proline modification; GO:0019538 protein metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071007 U2-type catalytic step 2 spliceosome; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003755 peptidyl-prolyl cis-trans isomerase activity; GO:0003824 catalytic activity; GO:0005488 binding; GO:0005515 protein binding; GO:0016018 cyclosporin A binding; GO:0016853 isomerase activity; GO:0016859 cis-trans isomerase activity; GO:0019904 protein domain specific binding; GO:0033218 amide binding; GO:0042277 peptide binding; GO:0097718 disordered domain specific binding; GO:0140096 catalytic activity"," acting on a protein;","PF00160","PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD","O","KOG0881","Cyclophilin type peptidyl-prolyl cis-trans isomerase",{"$nulls":3},"R-HSA-72163 mRNA Splicing - Major Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72163;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=TMED3 PE=1 SV=1","TMED3",0.986864735,0.716848784,"nochange",3012.39,3085.88,3204.93,3194.68,2882.74,3103.58,0.977826468,1.001681436,1.040325251,1.036998085,0.935741877,1.007426884,"mitochondria","K20350",null,null,"GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006890 retrograde vesicle-mediated transport"," Golgi to endoplasmic reticulum; GO:0016192 vesicle-mediated transport; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005789 endoplasmic reticulum membrane; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005798 Golgi-associated vesicle; GO:0012505 endomembrane system; GO:0012506 vesicle membrane; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030120 vesicle coat; GO:0030126 COPI vesicle coat; GO:0030133 transport vesicle; GO:0030135 coated vesicle; GO:0030137 COPI-coated vesicle; GO:0030659 cytoplasmic vesicle membrane; GO:0030660 Golgi-associated vesicle membrane; GO:0030662 coated vesicle membrane; GO:0030663 COPI-coated vesicle membrane; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032991 protein-containing complex; GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane; GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048475 coated membrane; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex; GO:0098827 endoplasmic reticulum subcompartment;",null,"PF01105","PF01105 emp24/gp25L/p24 family/GOLD","U","KOG1693","emp24/gp25L/p24 family of membrane trafficking proteins",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-8856688 Golgi-to-ER retrograde transport;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811434;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-8856688;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["Q9Y3Z3","Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2","SAMHD1",1.393407533,0.002239372,"up",8363.57,8677.74,7743.04,12147.1,11577.2,10810.4,0.845957917,0.877735567,0.783192583,1.228654201,1.171009988,1.093449743,"nucleus","K22544","SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]","hsa05170 Human immunodeficiency virus 1 infection; hsa03250 Viral life cycle - HIV-1; hsa04623 Cytosolic DNA-sensing pathway","GO:0002252 immune effector process; GO:0002376 immune system process; GO:0002682 regulation of immune system process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006195 purine nucleotide catabolic process; GO:0006203 dGTP catabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006952 defense response; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009143 nucleoside triphosphate catabolic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009146 purine nucleoside triphosphate catabolic process; GO:0009151 purine deoxyribonucleotide metabolic process; GO:0009155 purine deoxyribonucleotide catabolic process; GO:0009166 nucleotide catabolic process; GO:0009200 deoxyribonucleoside triphosphate metabolic process; GO:0009204 deoxyribonucleoside triphosphate catabolic process; GO:0009215 purine deoxyribonucleoside triphosphate metabolic process; GO:0009217 purine deoxyribonucleoside triphosphate catabolic process; GO:0009262 deoxyribonucleotide metabolic process; GO:0009264 deoxyribonucleotide catabolic process; GO:0009394 2'-deoxyribonucleotide metabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009615 response to virus; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019438 aromatic compound biosynthetic process; GO:0019439 aromatic compound catabolic process; GO:0019637 organophosphate metabolic process; GO:0019692 deoxyribose phosphate metabolic process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0031347 regulation of defense response; GO:0034097 response to cytokine; GO:0034340 response to type I interferon; GO:0034404 nucleobase-containing small molecule biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034655 nucleobase-containing compound catabolic process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044249 cellular biosynthetic process; GO:0044270 cellular nitrogen compound catabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0045087 innate immune response; GO:0045088 regulation of innate immune response; GO:0046060 dATP metabolic process; GO:0046061 dATP catabolic process; GO:0046070 dGTP metabolic process; GO:0046386 deoxyribose phosphate catabolic process; GO:0046434 organophosphate catabolic process; GO:0046483 heterocycle metabolic process; GO:0046700 heterocycle catabolic process; GO:0048583 regulation of response to stimulus; GO:0050776 regulation of immune response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051262 protein tetramerization; GO:0051289 protein homotetramerization; GO:0051607 defense response to virus; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0060337 type I interferon signaling pathway; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071357 cellular response to type I interferon; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0072521 purine-containing compound metabolic process; GO:0072523 purine-containing compound catabolic process; GO:0080134 regulation of response to stress; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0098542 defense response to other organism; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901292 nucleoside phosphate catabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1901361 organic cyclic compound catabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0000166 nucleotide binding; GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004540 ribonuclease activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0008832 dGTPase activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016793 triphosphoric monoester hydrolase activity; GO:0017076 purine nucleotide binding; GO:0019001 guanyl nucleotide binding; GO:0032552 deoxyribonucleotide binding; GO:0032554 purine deoxyribonucleotide binding; GO:0032560 guanyl deoxyribonucleotide binding; GO:0032567 dGTP binding; GO:0036094 small molecule binding; GO:0042578 phosphoric ester hydrolase activity; GO:0042802 identical protein binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0140098 catalytic activity"," acting on RNA; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF07647","PF07647 SAM domain (Sterile alpha motif)","S","KOG2681","Metal-dependent phosphohydrolase","WP4705 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING","http://www.wikipathways.org/instance/WP4705_r119081",null,"R-HSA-1280215 Cytokine Signaling in Immune system;R-HSA-1430728 Metabolism;R-HSA-15869 Metabolism of nucleotides;R-HSA-168256 Immune System;R-HSA-8956319 Nucleotide catabolism;R-HSA-909733 Interferon alpha/beta signaling;R-HSA-913531 Interferon Signaling","https://reactome.org/PathwayBrowser/#/R-HSA-1280215;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-15869;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-8956319;https://reactome.org/PathwayBrowser/#/R-HSA-909733;https://reactome.org/PathwayBrowser/#/R-HSA-913531","INTERFERON GAMMA RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE"]
["Q9Y4D7","Plexin-D1 OS=Homo sapiens OX=9606 GN=PLXND1 PE=1 SV=3","PLXND1",0.606856967,1.29437E-3,"down",8591.61,8622.66,8175.09,4839.69,5769.69,4798.33,1.2635628,1.268129304,1.20230546,0.711770233,0.848544761,0.705687443,"plasma membrane","K06822",null,null,"GO:0001525 angiogenesis; GO:0001568 blood vessel development; GO:0001569 branching involved in blood vessel morphogenesis; GO:0001667 ameboidal-type cell migration; GO:0001763 morphogenesis of a branching structure; GO:0001944 vasculature development; GO:0002009 morphogenesis of an epithelium; GO:0003007 heart morphogenesis; GO:0003151 outflow tract morphogenesis; GO:0003205 cardiac chamber development; GO:0003279 cardiac septum development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006928 movement of cell or subcellular component; GO:0007154 cell communication; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007219 Notch signaling pathway; GO:0007221 positive regulation of transcription of Notch receptor target; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007416 synapse assembly; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007507 heart development; GO:0008360 regulation of cell shape; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010631 epithelial cell migration; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0022612 gland morphogenesis; GO:0023052 signaling; GO:0030154 cell differentiation; GO:0030155 regulation of cell adhesion; GO:0030334 regulation of cell migration; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0032092 positive regulation of protein binding; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0035239 tube morphogenesis; GO:0035272 exocrine system development; GO:0035295 tube development; GO:0035904 aorta development; GO:0040011 locomotion; GO:0040012 regulation of locomotion; GO:0043087 regulation of GTPase activity; GO:0043393 regulation of protein binding; GO:0043542 endothelial cell migration; GO:0044085 cellular component biogenesis; GO:0044093 positive regulation of molecular function; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0045765 regulation of angiogenesis; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048513 animal organ development; GO:0048514 blood vessel morphogenesis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048699 generation of neurons; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050770 regulation of axonogenesis; GO:0050772 positive regulation of axonogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050808 synapse organization; GO:0050896 response to stimulus; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051099 positive regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051270 regulation of cellular component movement; GO:0051336 regulation of hydrolase activity; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060445 branching involved in salivary gland morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0060600 dichotomous subdivision of an epithelial terminal unit; GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching; GO:0060840 artery development; GO:0060976 coronary vasculature development; GO:0061138 morphogenesis of a branching epithelium; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071526 semaphorin-plexin signaling pathway; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0080090 regulation of primary metabolic process; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:1901342 regulation of vasculature development; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000145 regulation of cell motility; GO:2001141 regulation of RNA biosynthetic process;","GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030027 lamellipodium; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031252 cell leading edge; GO:0042995 cell projection; GO:0071944 cell periphery; GO:0120025 plasma membrane bounded cell projection;","GO:0004888 transmembrane signaling receptor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0017154 semaphorin receptor activity; GO:0019904 protein domain specific binding; GO:0038023 signaling receptor activity; GO:0060089 molecular transducer activity;","PF17960; PF01833","PF17960 TIG domain; PF01833 IPT/TIG domain","T","KOG3610","Plexins (functional semaphorin receptors)","WP5074 KALLMANN SYNDROME","http://www.wikipathways.org/instance/WP5074_r120388",null,"R-HSA-1266738 Developmental Biology;R-HSA-157118 Signaling by NOTCH;R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-373755 Semaphorin interactions;R-HSA-416700 Other semaphorin interactions;R-HSA-422475 Axon guidance;R-HSA-9012852 Signaling by NOTCH3;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription;R-HSA-9675108 Nervous system development;R-HSA-9696270 RND2 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-157118;https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-373755;https://reactome.org/PathwayBrowser/#/R-HSA-416700;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-9012852;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013508;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9696270;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q9Y4L1","Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1","HYOU1",0.934987317,0.0142344,"nochange",228341,229725,233799,211422,213631,221832,1.023377031,1.029579832,1.047838655,0.94754958,0.95744986,0.994205042,"endoplasmic reticulum","K09486","HYOU1; hypoxia up-regulated 1","hsa04141 Protein processing in endoplasmic reticulum","GO:0000003 reproduction; GO:0001666 response to hypoxia; GO:0002931 response to ischemia; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009628 response to abiotic stimulus; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0016192 vesicle-mediated transport; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030968 endoplasmic reticulum unfolded protein response; GO:0032501 multicellular organismal process; GO:0032504 multicellular organism reproduction; GO:0033554 cellular response to stress; GO:0034620 cellular response to unfolded protein; GO:0034976 response to endoplasmic reticulum stress; GO:0035966 response to topologically incorrect protein; GO:0035967 cellular response to topologically incorrect protein; GO:0036293 response to decreased oxygen levels; GO:0036294 cellular response to decreased oxygen levels; GO:0036498 IRE1-mediated unfolded protein response; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043523 regulation of neuron apoptotic process; GO:0043524 negative regulation of neuron apoptotic process; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071453 cellular response to oxygen levels; GO:0071456 cellular response to hypoxia; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0098657 import into cell; GO:1900037 regulation of cellular response to hypoxia; GO:1900038 negative regulation of cellular response to hypoxia; GO:1901214 regulation of neuron death; GO:1901215 negative regulation of neuron death; GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903297 regulation of hypoxia-induced intrinsic apoptotic signaling pathway; GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; GO:1903381 regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway; GO:1903573 negative regulation of response to endoplasmic reticulum stress; GO:1905897 regulation of response to endoplasmic reticulum stress; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway; GO:2001242 regulation of intrinsic apoptotic signaling pathway; GO:2001243 negative regulation of intrinsic apoptotic signaling pathway;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005790 smooth endoplasmic reticulum; GO:0012505 endomembrane system; GO:0030139 endocytic vesicle; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0034663 endoplasmic reticulum chaperone complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071682 endocytic vesicle lumen; GO:0097708 intracellular vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0051087 chaperone binding;",null,null,"O","KOG0104","Molecular chaperones GRP170/SIL1"," HSP70 superfamily","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782",null,"R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors;R-HSA-2262752 Cellular responses to stress;R-HSA-3000484 Scavenging by Class F Receptors;R-HSA-381038 XBP1(S) activates chaperone genes;R-HSA-381070 IRE1alpha activates chaperones;R-HSA-381119 Unfolded Protein Response (UPR);R-HSA-5653656 Vesicle-mediated transport;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2173782;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3000484;https://reactome.org/PathwayBrowser/#/R-HSA-381038;https://reactome.org/PathwayBrowser/#/R-HSA-381070;https://reactome.org/PathwayBrowser/#/R-HSA-381119;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-8953897","UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["Q9Y547","Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=HSPB11 PE=1 SV=1","HSPB11",1.067345718,0.378853252,"nochange",38256.5,32153.6,32733.8,36015.3,34607.4,39467.5,1.076464787,0.904740846,0.921066565,1.013401703,0.973786088,1.110540012,"cytoskeleton","K19369",null,null,"GO:0001501 skeletal system development; GO:0003002 regionalization; GO:0006810 transport; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007017 microtubule-based process; GO:0007018 microtubule-based movement; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007224 smoothened signaling pathway; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007507 heart development; GO:0009798 axis specification; GO:0009987 cellular process; GO:0010970 transport along microtubule; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030323 respiratory tube development; GO:0030324 lung development; GO:0030705 cytoskeleton-dependent intracellular transport; GO:0031503 protein-containing complex localization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035295 tube development; GO:0035735 intraciliary transport involved in cilium assembly; GO:0042073 intraciliary transport; GO:0044085 cellular component biogenesis; GO:0044782 cilium organization; GO:0046907 intracellular transport; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051716 cellular response to stimulus; GO:0060271 cilium assembly; GO:0060541 respiratory system development; GO:0060972 left/right pattern formation; GO:0065007 biological regulation; GO:0070925 organelle assembly; GO:0070986 left/right axis specification; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0099111 microtubule-based transport; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization;","GO:0005622 intracellular anatomical structure; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0005929 cilium; GO:0015630 microtubule cytoskeleton; GO:0030990 intraciliary transport particle; GO:0030992 intraciliary transport particle B; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0097542 ciliary tip; GO:0120025 plasma membrane bounded cell projection;",null,"PF00754","PF00754 F5/8 type C domain","DO","KOG3437","Anaphase-promoting complex (APC)"," subunit 10","WP4352 CILIARY LANDSCAPE;WP4830 GDNFRET SIGNALING AXIS;WP4536 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR;WP4532 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN","http://www.wikipathways.org/instance/WP4352_r102218;http://www.wikipathways.org/instance/WP4830_r118773;http://www.wikipathways.org/instance/WP4536_r110928;http://www.wikipathways.org/instance/WP4532_r103287",null,"R-HSA-1852241 Organelle biogenesis and maintenance;R-HSA-5617833 Cilium Assembly;R-HSA-5620924 Intraflagellar transport","https://reactome.org/PathwayBrowser/#/R-HSA-1852241;https://reactome.org/PathwayBrowser/#/R-HSA-5617833;https://reactome.org/PathwayBrowser/#/R-HSA-5620924"]
["Q9Y5K6","CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1","CD2AP",1.106837262,0.060792351,"nochange",28909.1,27396.3,29206.9,29892.9,33533,31222.3,0.962778189,0.912396447,0.972696013,0.995542308,1.116770879,1.039816164,"nucleus","K13738","CD2AP; CD2-associated protein","hsa05100 Bacterial invasion of epithelial cells","GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0006508 proteolysis; GO:0006511 ubiquitin-dependent protein catabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0006929 substrate-dependent cell migration; GO:0006930 substrate-dependent cell migration"," cell extension; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007154 cell communication; GO:0007155 cell adhesion; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010498 proteasomal protein catabolic process; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016477 cell migration; GO:0019538 protein metabolic process; GO:0019941 modification-dependent protein catabolic process; GO:0022607 cellular component assembly; GO:0022610 biological adhesion; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0030029 actin filament-based process; GO:0030030 cell projection organization; GO:0030031 cell projection assembly; GO:0030036 actin cytoskeleton organization; GO:0030100 regulation of endocytosis; GO:0030163 protein catabolic process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032908 regulation of transforming growth factor beta1 production; GO:0032911 negative regulation of transforming growth factor beta1 production; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0040011 locomotion; GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0043170 macromolecule metabolic process; GO:0043632 modification-dependent macromolecule catabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044248 cellular catabolic process; GO:0044257 cellular protein catabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044265 cellular macromolecule catabolic process; GO:0044267 cellular protein metabolic process; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051049 regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051058 negative regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051179 localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051493 regulation of cytoskeleton organization; GO:0051603 proteolysis involved in cellular protein catabolic process; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060341 regulation of cellular localization; GO:0060627 regulation of vesicle-mediated transport; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071634 regulation of transforming growth factor beta production; GO:0071635 negative regulation of transforming growth factor beta production; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0097435 supramolecular fiber organization; GO:0098609 cell-cell adhesion; GO:0120031 plasma membrane bounded cell projection assembly; GO:0120036 plasma membrane bounded cell projection organization; GO:1900180 regulation of protein localization to nucleus; GO:1900182 positive regulation of protein localization to nucleus; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903829 positive regulation of protein localization; GO:2000249 regulation of actin cytoskeleton reorganization;","GO:0001726 ruffle; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0005884 actin filament; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0005938 cell cortex; GO:0015629 actin cytoskeleton; GO:0016020 membrane; GO:0030054 cell junction; GO:0030139 endocytic vesicle; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031941 filamentous actin; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber; GO:0099513 polymeric cytoskeletal fiber; GO:0099568 cytoplasmic region; GO:0120025 plasma membrane bounded cell projection;","GO:0005102 signaling receptor binding; GO:0005126 cytokine receptor binding; GO:0005172 vascular endothelial growth factor receptor binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008013 beta-catenin binding; GO:0008022 protein C-terminus binding; GO:0017124 SH3 domain binding; GO:0019904 protein domain specific binding; GO:0044877 protein-containing complex binding; GO:0045296 cadherin binding; GO:0050839 cell adhesion molecule binding; GO:0070851 growth factor receptor binding;","PF14604; PF00018","PF14604 Variant SH3 domain; PF00018 SH3 domain","T","KOG4348","Adaptor protein CMS/SETA","WP4823 GENES CONTROLLING NEPHROGENESIS;WP4758 NEPHROTIC SYNDROME;WP2572 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS","http://www.wikipathways.org/instance/WP4823_r119116;http://www.wikipathways.org/instance/WP4758_r108284;http://www.wikipathways.org/instance/WP2572_r119251",null,"R-HSA-1500931 Cell-Cell communication;R-HSA-373753 Nephrin family interactions","https://reactome.org/PathwayBrowser/#/R-HSA-1500931;https://reactome.org/PathwayBrowser/#/R-HSA-373753","MITOTIC SPINDLE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MITOTIC_SPINDLE"]
["Q9Y5L4","Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1","TIMM13",1.327766128,8.67419E-3,"up",97408,90563.6,80709,113492,122689,120564,0.934480456,0.868818929,0.774279147,1.088781783,1.177012901,1.156626783,"extracellular","K17781",null,null,"GO:0003008 system process; GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007007 inner mitochondrial membrane organization; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0008104 protein localization; GO:0009987 cellular process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0017038 protein import; GO:0032501 multicellular organismal process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0044743 protein transmembrane import into intracellular organelle; GO:0045039 protein insertion into mitochondrial inner membrane; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0050877 nervous system process; GO:0050954 sensory perception of mechanical stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0055085 transmembrane transport; GO:0061024 membrane organization; GO:0065002 intracellular protein transmembrane transport; GO:0070585 protein localization to mitochondrion; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071806 protein transmembrane transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:0072657 protein localization to membrane; GO:0090150 establishment of protein localization to membrane; GO:0090151 establishment of protein localization to mitochondrial membrane; GO:1990542 mitochondrial transmembrane transport;","GO:0001650 fibrillar center; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005744 TIM23 mitochondrial import inner membrane translocase complex; GO:0005758 mitochondrial intermembrane space; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0042719 mitochondrial intermembrane space protein transporter complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0098796 membrane protein complex; GO:0098798 mitochondrial protein-containing complex; GO:0098800 inner mitochondrial membrane protein complex; GO:1990351 transporter complex;","GO:0005215 transporter activity; GO:0005488 binding; GO:0008270 zinc ion binding; GO:0008320 protein transmembrane transporter activity; GO:0015399 primary active transmembrane transporter activity; GO:0015450 protein-transporting ATPase activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022884 macromolecule transmembrane transporter activity; GO:0042887 amide transmembrane transporter activity; GO:0043167 ion binding; GO:0043169 cation binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:1904680 peptide transmembrane transporter activity;","PF02953","PF02953 Tim10/DDP family zinc finger","U","KOG1733","Mitochondrial import inner membrane translocase"," subunit TIM13",{"$nulls":3},"R-HSA-1268020 Mitochondrial protein import;R-HSA-9609507 Protein localization","https://reactome.org/PathwayBrowser/#/R-HSA-1268020;https://reactome.org/PathwayBrowser/#/R-HSA-9609507","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["Q9Y5Z4","Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1","HEBP2",1.48548605,0.005642553,"up",5249.35,5905.15,6103.38,7879.21,8245.18,9511.95,0.734273755,0.826006394,0.853734606,1.102135905,1.153327418,1.330521921,"cytoplasm",{"$nulls":3},"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0009987 cellular process; GO:0010917 negative regulation of mitochondrial membrane potential; GO:0010939 regulation of necrotic cell death; GO:0010940 positive regulation of necrotic cell death; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0032940 secretion by cell; GO:0035794 positive regulation of mitochondrial membrane permeability; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0042391 regulation of membrane potential; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045837 negative regulation of membrane potential; GO:0046902 regulation of mitochondrial membrane permeability; GO:0046903 secretion; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051881 regulation of mitochondrial membrane potential; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0090559 regulation of membrane permeability; GO:1905710 positive regulation of membrane permeability;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005764 lysosome; GO:0005766 primary lysosome; GO:0005773 vacuole; GO:0005775 vacuolar lumen; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0035578 azurophil granule lumen; GO:0042582 azurophil granule; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle;",{"$nulls":9},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["Q9Y617","Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2","PSAT1",0.500008061,{"v":5.86712e-05,"d":"5.87E-05"},"down",92971.5,81948.9,85582.2,43788.2,44065.5,42399.7,1.427563492,1.258313116,1.314101895,0.672361269,0.676619169,0.651041059,"cytoplasm","K00831","serC; phosphoserine aminotransferase [EC:2.6.1.52]","hsa00260 Glycine"," serine and threonine metabolism; hsa00270 Cysteine and methionine metabolism; hsa01240 Biosynthesis of cofactors; hsa01200 Carbon metabolism; hsa00750 Vitamin B6 metabolism; hsa01230 Biosynthesis of amino acids; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006520 cellular amino acid metabolic process; GO:0006563 L-serine metabolic process; GO:0006564 L-serine biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006766 vitamin metabolic process; GO:0006767 water-soluble vitamin metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008614 pyridoxine metabolic process; GO:0008615 pyridoxine biosynthetic process; GO:0008652 cellular amino acid biosynthetic process; GO:0009058 biosynthetic process; GO:0009069 serine family amino acid metabolic process; GO:0009070 serine family amino acid biosynthetic process; GO:0009110 vitamin biosynthetic process; GO:0009987 cellular process; GO:0016053 organic acid biosynthetic process; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0019752 carboxylic acid metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0042364 water-soluble vitamin biosynthetic process; GO:0042816 vitamin B6 metabolic process; GO:0042819 vitamin B6 biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0044283 small molecule biosynthetic process; GO:0046394 carboxylic acid biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0072524 pyridine-containing compound metabolic process; GO:0072525 pyridine-containing compound biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901605 alpha-amino acid metabolic process; GO:1901607 alpha-amino acid biosynthetic process; GO:1901615 organic hydroxy compound metabolic process; GO:1901617 organic hydroxy compound biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0003824 catalytic activity; GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity; GO:0008483 transaminase activity; GO:0016740 transferase activity; GO:0016769 transferase activity"," transferring nitrogenous groups;","PF00266","PF00266 Aminotransferase class-V","HE","KOG2790","Phosphoserine aminotransferase","WP4018 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS;WP4673 MALE INFERTILITY;WP4290 METABOLIC REPROGRAMMING IN COLON CANCER;WP5083 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING;WP4688 SERINE METABOLISM;WP2525 TRANSSULFURATION AND ONECARBON METABOLISM","http://www.wikipathways.org/instance/WP4018_r117168;http://www.wikipathways.org/instance/WP4673_r119920;http://www.wikipathways.org/instance/WP4290_r118611;http://www.wikipathways.org/instance/WP5083_r120385;http://www.wikipathways.org/instance/WP4688_r120418;http://www.wikipathways.org/instance/WP2525_r116582",null,"R-HSA-1430728 Metabolism;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-977347 Serine biosynthesis","https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-977347","MTORC1 SIGNALING;UNFOLDED PROTEIN RESPONSE","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UNFOLDED_PROTEIN_RESPONSE"]
["Q9Y6B7","AP-4 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP4B1 PE=1 SV=2","AP4B1",0.628501712,0.020909367,"nochange",4786.25,5312.27,4482.92,3415.78,3371.8,2376.88,1.20936667,1.342278878,1.132722702,0.86308289,0.851970235,0.600578626,"cytoplasm","nucleus","K12401","AP4B1; AP-4 complex subunit beta-1","hsa04142 Lysosome","GO:0006605 protein targeting; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0008104 protein localization; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016192 vesicle-mediated transport; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0042886 amide transport; GO:0045184 establishment of protein localization; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0061938 protein localization to somatodendritic compartment; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005802 trans-Golgi network; GO:0005829 cytosol; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019898 extrinsic component of membrane; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0030124 AP-4 adaptor complex; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031904 endosome lumen; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048475 coated membrane; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex;",null,"PF09066","PF09066 Beta2-adaptin appendage"," C-terminal sub-domain","U","KOG1061","Vesicle coat complex AP-1/AP-2/AP-4"," beta subunit",{"$nulls":3},"R-HSA-199991 Membrane Trafficking;R-HSA-199992 trans-Golgi Network Vesicle Budding;R-HSA-432720 Lysosome Vesicle Biogenesis;R-HSA-432722 Golgi Associated Vesicle Biogenesis;R-HSA-5653656 Vesicle-mediated transport","https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-199992;https://reactome.org/PathwayBrowser/#/R-HSA-432720;https://reactome.org/PathwayBrowser/#/R-HSA-432722;https://reactome.org/PathwayBrowser/#/R-HSA-5653656","XENOBIOTIC METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_XENOBIOTIC_METABOLISM"]
["Q9Y6J0","Calcineurin-binding protein cabin-1 OS=Homo sapiens OX=9606 GN=CABIN1 PE=1 SV=1","CABIN1",0.747545762,0.044587441,"nochange",6811.53,6101.25,7108.71,5475.83,4116.07,5375.08,1.168075655,1.046273244,1.219037586,0.939023055,0.705844525,0.921745935,"nucleus","K17613",null,null,"GO:0006323 DNA packaging; GO:0006325 chromatin organization; GO:0006333 chromatin assembly or disassembly; GO:0006334 nucleosome assembly; GO:0006336 DNA replication-independent chromatin assembly; GO:0006996 organelle organization; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010921 regulation of phosphatase activity; GO:0010923 negative regulation of phosphatase activity; GO:0010941 regulation of cell death; GO:0014823 response to activity; GO:0016043 cellular component organization; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0031497 chromatin assembly; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032515 negative regulation of phosphoprotein phosphatase activity; GO:0034724 DNA replication-independent chromatin organization; GO:0034728 nucleosome organization; GO:0035303 regulation of dephosphorylation; GO:0035304 regulation of protein dephosphorylation; GO:0035305 negative regulation of dephosphorylation; GO:0035308 negative regulation of protein dephosphorylation; GO:0043086 negative regulation of catalytic activity; GO:0043666 regulation of phosphoprotein phosphatase activity; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0045936 negative regulation of phosphate metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051276 chromosome organization; GO:0051336 regulation of hydrolase activity; GO:0051346 negative regulation of hydrolase activity; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065003 protein-containing complex assembly; GO:0065004 protein-DNA complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071103 DNA conformation change; GO:0071824 protein-DNA complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0016234 inclusion body; GO:0016235 aggresome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0004857 enzyme inhibitor activity; GO:0004864 protein phosphatase inhibitor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019208 phosphatase regulator activity; GO:0019212 phosphatase inhibitor activity; GO:0019888 protein phosphatase regulator activity; GO:0019899 enzyme binding; GO:0019902 phosphatase binding; GO:0019903 protein phosphatase binding; GO:0019904 protein domain specific binding; GO:0030234 enzyme regulator activity; GO:0030346 protein phosphatase 2B binding; GO:0098772 molecular function regulator;","PF09047","PF09047 MEF2 binding",{"$nulls":6},"R-HSA-2262752 Cellular responses to stress;R-HSA-2559583 Cellular Senescence;R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF);R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2559583;https://reactome.org/PathwayBrowser/#/R-HSA-2559584;https://reactome.org/PathwayBrowser/#/R-HSA-2559586;https://reactome.org/PathwayBrowser/#/R-HSA-8953897"]
["Q9Y6M7","Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2","SLC4A7",0.518046464,0.079378276,"nochange",1954.58,2116.67,4055.55,1082.53,1653.88,1473.65,0.950604935,1.029436988,1.972406269,0.52648567,0.804360267,0.716705872,"plasma membrane","K13858",null,null,"GO:0001654 eye development; GO:0001754 eye photoreceptor cell differentiation; GO:0001944 vasculature development; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003008 system process; GO:0003407 neural retina development; GO:0006810 transport; GO:0006811 ion transport; GO:0006812 cation transport; GO:0006814 sodium ion transport; GO:0006820 anion transport; GO:0006821 chloride transport; GO:0006873 cellular ion homeostasis; GO:0006885 regulation of pH; GO:0007154 cell communication; GO:0007267 cell-cell signaling; GO:0007268 chemical synaptic transmission; GO:0007271 synaptic transmission"," cholinergic; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0007423 sensory organ development; GO:0007600 sensory perception; GO:0007601 visual perception; GO:0008219 cell death; GO:0008544 epidermis development; GO:0009653 anatomical structure morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009913 epidermal cell differentiation; GO:0009987 cellular process; GO:0010623 programmed cell death involved in cell development; GO:0010646 regulation of cell communication; GO:0012501 programmed cell death; GO:0015698 inorganic anion transport; GO:0015701 bicarbonate transport; GO:0015711 organic anion transport; GO:0019725 cellular homeostasis; GO:0021548 pons development; GO:0021747 cochlear nucleus development; GO:0022008 neurogenesis; GO:0022037 metencephalon development; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0030001 metal ion transport; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030641 regulation of cellular pH; GO:0030855 epithelial cell differentiation; GO:0030902 hindbrain development; GO:0032228 regulation of synaptic transmission"," GABAergic; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034220 ion transmembrane transport; GO:0035315 hair cell differentiation; GO:0035725 sodium ion transmembrane transport; GO:0042221 response to chemical; GO:0042490 mechanoreceptor differentiation; GO:0042491 inner ear auditory receptor cell differentiation; GO:0042592 homeostatic process; GO:0043010 camera-type eye development; GO:0043583 ear development; GO:0046530 photoreceptor cell differentiation; GO:0046666 retinal cell programmed cell death; GO:0046685 response to arsenic-containing substance; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048592 eye morphogenesis; GO:0048593 camera-type eye morphogenesis; GO:0048666 neuron development; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048839 inner ear development; GO:0048856 anatomical structure development; GO:0048857 neural nucleus development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0050804 modulation of chemical synaptic transmission; GO:0050877 nervous system process; GO:0050896 response to stimulus; GO:0050953 sensory perception of light stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051453 regulation of intracellular pH; GO:0055067 monovalent inorganic cation homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0055085 transmembrane transport; GO:0060041 retina development in camera-type eye; GO:0060042 retina morphogenesis in camera-type eye; GO:0060113 inner ear receptor cell differentiation; GO:0060117 auditory receptor cell development; GO:0060119 inner ear receptor cell development; GO:0060219 camera-type eye photoreceptor cell differentiation; GO:0060322 head development; GO:0060429 epithelium development; GO:0060563 neuroepithelial cell differentiation; GO:0061298 retina vasculature development in camera-type eye; GO:0061299 retina vasculature morphogenesis in camera-type eye; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071702 organic substance transport; GO:0072359 circulatory system development; GO:0090596 sensory organ morphogenesis; GO:0098655 cation transmembrane transport; GO:0098656 anion transmembrane transport; GO:0098660 inorganic ion transmembrane transport; GO:0098661 inorganic anion transmembrane transport; GO:0098662 inorganic cation transmembrane transport; GO:0098771 inorganic ion homeostasis; GO:0098916 anterograde trans-synaptic signaling; GO:0099177 regulation of trans-synaptic signaling; GO:0099536 synaptic signaling; GO:0099537 trans-synaptic signaling; GO:1902476 chloride transmembrane transport; GO:1902600 proton transmembrane transport;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005887 integral component of plasma membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0016323 basolateral plasma membrane; GO:0016324 apical plasma membrane; GO:0031224 intrinsic component of membrane; GO:0031226 intrinsic component of plasma membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032420 stereocilium; GO:0032421 stereocilium bundle; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0045177 apical part of cell; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0098590 plasma membrane region; GO:0098858 actin-based cell projection; GO:0098862 cluster of actin-based cell projections; GO:0120025 plasma membrane bounded cell projection;","GO:0005215 transporter activity; GO:0005452 inorganic anion exchanger activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008324 cation transmembrane transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008510 sodium:bicarbonate symporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015081 sodium ion transmembrane transporter activity; GO:0015103 inorganic anion transmembrane transporter activity; GO:0015106 bicarbonate transmembrane transporter activity; GO:0015108 chloride transmembrane transporter activity; GO:0015291 secondary active transmembrane transporter activity; GO:0015293 symporter activity; GO:0015294 solute:cation symporter activity; GO:0015297 antiporter activity; GO:0015301 anion:anion antiporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0015370 solute:sodium symporter activity; GO:0022804 active transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0022890 inorganic cation transmembrane transporter activity; GO:0042802 identical protein binding; GO:0046873 metal ion transmembrane transporter activity;","PF07565","PF07565 Band 3 cytoplasmic domain","P","KOG1172","Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family)","WP4754 IL18 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP4754_r115147",null,"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-382551 Transport of small molecules;R-HSA-425381 Bicarbonate transporters;R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides;R-HSA-425407 SLC-mediated transmembrane transport;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013405 RHOD GTPase cycle;R-HSA-9013406 RHOQ GTPase cycle;R-HSA-9013407 RHOH GTPase cycle;R-HSA-9013409 RHOJ GTPase cycle;R-HSA-9035034 RHOF GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-382551;https://reactome.org/PathwayBrowser/#/R-HSA-425381;https://reactome.org/PathwayBrowser/#/R-HSA-425393;https://reactome.org/PathwayBrowser/#/R-HSA-425407;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013405;https://reactome.org/PathwayBrowser/#/R-HSA-9013406;https://reactome.org/PathwayBrowser/#/R-HSA-9013407;https://reactome.org/PathwayBrowser/#/R-HSA-9013409;https://reactome.org/PathwayBrowser/#/R-HSA-9035034;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["A3KN83","Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1","SBNO1",1.49748322,0.000129215,"up",18942,20370.1,19672,28763.8,29059.5,30504.4,0.771506424,0.829672844,0.801239276,1.171547697,1.183591538,1.242442221,"nucleus",{"$nulls":3},"GO:0001775 cell activation; GO:0002237 response to molecule of bacterial origin; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002281 macrophage activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006955 immune response; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031347 regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032496 response to lipopolysaccharide; GO:0033993 response to lipid; GO:0034097 response to cytokine; GO:0042116 macrophage activation; GO:0042221 response to chemical; GO:0043207 response to external biotic stimulus; GO:0045321 leukocyte activation; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0050727 regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051707 response to other organism; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070741 response to interleukin-6; GO:0070887 cellular response to chemical stimulus; GO:0071105 response to interleukin-11; GO:0071216 cellular response to biotic stimulus; GO:0071219 cellular response to molecule of bacterial origin; GO:0071222 cellular response to lipopolysaccharide; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071348 cellular response to interleukin-11; GO:0071354 cellular response to interleukin-6; GO:0071396 cellular response to lipid; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;",null,null,"PF13872; PF13871","PF13872 P-loop containing NTP hydrolase pore-1; PF13871 C-terminal domain on Strawberry notch homologue","KT","KOG1513","Nuclear helicase MOP-3/SNO (DEAD-box superfamily)"]
["A6NHX0","Cytosolic arginine sensor for mTORC1 subunit 2 OS=Homo sapiens OX=9606 GN=CASTOR2 PE=1 SV=3","CASTOR2",1.435980849,0.092728255,"nochange",1478.1,1214.35,1666.48,2018.12,2593.91,1647.31,0.835220803,0.686185226,0.941667522,1.140366557,1.465724643,0.930835249,"cytoplasm","K23081","CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2","hsa04150 mTOR signaling pathway","GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0023051 regulation of signaling; GO:0023057 negative regulation of signaling; GO:0032006 regulation of TOR signaling; GO:0032007 negative regulation of TOR signaling; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1903432 regulation of TORC1 signaling; GO:1904262 negative regulation of TORC1 signaling;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;","GO:0005488 binding; GO:0005515 protein binding; GO:0042802 identical protein binding;","PF18700; PF13840","PF18700 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain; PF13840 ACT domain ",{"$nulls":6},"R-HSA-2262752 Cellular responses to stress;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9639288 Amino acids regulate mTORC1;R-HSA-9711097 Cellular response to starvation","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9639288;https://reactome.org/PathwayBrowser/#/R-HSA-9711097"]
["O60234","Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1","GMFG",0.944803052,0.168985666,"nochange",110551,115044,104695,103337,100853,107869,1.032625566,1.074593406,0.97792633,0.965241637,0.942039296,1.007573764,"cytoplasm",{"$nulls":3},"GO:0000003 reproduction; GO:0001667 ameboidal-type cell migration; GO:0001775 cell activation; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0003006 developmental process involved in reproduction; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006887 exocytosis; GO:0006928 movement of cell or subcellular component; GO:0006955 immune response; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008152 metabolic process; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010631 epithelial cell migration; GO:0010639 negative regulation of organelle organization; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0030029 actin filament-based process; GO:0030154 cell differentiation; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032940 secretion by cell; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033673 negative regulation of kinase activity; GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation; GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation; GO:0036211 protein modification process; GO:0036230 granulocyte activation; GO:0040011 locomotion; GO:0042119 neutrophil activation; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0046903 secretion; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051014 actin filament severing; GO:0051125 regulation of actin nucleation; GO:0051126 negative regulation of actin nucleation; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071846 actin filament debranching; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0110053 regulation of actin filament organization; GO:1901564 organonitrogen compound metabolic process; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0012505 endomembrane system; GO:0030027 lamellipodium; GO:0030141 secretory granule; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0034774 secretory granule lumen; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:0120025 plasma membrane bounded cell projection; GO:1904813 ficolin-1-rich granule lumen;","GO:0004857 enzyme inhibitor activity; GO:0004860 protein kinase inhibitor activity; GO:0005488 binding; GO:0008047 enzyme activator activity; GO:0019207 kinase regulator activity; GO:0019210 kinase inhibitor activity; GO:0019887 protein kinase regulator activity; GO:0030234 enzyme regulator activity; GO:0044877 protein-containing complex binding; GO:0071933 Arp2/3 complex binding; GO:0098772 molecular function regulator;","PF00241","PF00241 Cofilin/tropomyosin-type actin-binding protein","W","KOG1736","Glia maturation factor beta",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["O94903","Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1","PLPBP",1.23171872,0.000246322,"up",61572.2,58816.9,59821.2,72684.5,73961.1,75322.8,0.918579726,0.877474118,0.89245701,1.084361255,1.103406521,1.123721371,"cytoplasm","K06997",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;","GO:0005488 binding; GO:0019842 vitamin binding; GO:0030170 pyridoxal phosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0070279 vitamin B6 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF01168","PF01168 Alanine racemase"," N-terminal domain","R","KOG3157","Proline synthetase co-transcribed protein"]
["O95757","Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3","HSPA4L",0.840535023,0.012129057,"nochange",22656.9,22972.9,20887,19368.5,18839.4,17701.8,1.110391949,1.125878793,1.023650925,0.949230763,0.923300103,0.867547467,"cytoplasm","K09485","HSP110; heat shock protein 110kDa","hsa04141 Protein processing in endoplasmic reticulum","GO:0002682 regulation of immune system process; GO:0002684 positive regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002696 positive regulation of leukocyte activation; GO:0006457 protein folding; GO:0006605 protein targeting; GO:0006626 protein targeting to mitochondrion; GO:0006810 transport; GO:0006839 mitochondrial transport; GO:0006886 intracellular protein transport; GO:0006897 endocytosis; GO:0006898 receptor-mediated endocytosis; GO:0006950 response to stress; GO:0006986 response to unfolded protein; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0007006 mitochondrial membrane organization; GO:0007275 multicellular organism development; GO:0007568 aging; GO:0008104 protein localization; GO:0008340 determination of adult lifespan; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010259 multicellular organism aging; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0017038 protein import; GO:0019222 regulation of metabolic process; GO:0022407 regulation of cell-cell adhesion; GO:0022409 positive regulation of cell-cell adhesion; GO:0022607 cellular component assembly; GO:0030155 regulation of cell adhesion; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0034613 cellular protein localization; GO:0035966 response to topologically incorrect protein; GO:0042221 response to chemical; GO:0042886 amide transport; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045040 protein insertion into mitochondrial outer membrane; GO:0045184 establishment of protein localization; GO:0045343 regulation of MHC class I biosynthetic process; GO:0045345 positive regulation of MHC class I biosynthetic process; GO:0045785 positive regulation of cell adhesion; GO:0046634 regulation of alpha-beta T cell activation; GO:0046635 positive regulation of alpha-beta T cell activation; GO:0046907 intracellular transport; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050863 regulation of T cell activation; GO:0050865 regulation of cell activation; GO:0050867 positive regulation of cell activation; GO:0050870 positive regulation of T cell activation; GO:0050896 response to stimulus; GO:0051131 chaperone-mediated protein complex assembly; GO:0051133 regulation of NK T cell activation; GO:0051135 positive regulation of NK T cell activation; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051249 regulation of lymphocyte activation; GO:0051251 positive regulation of lymphocyte activation; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060255 regulation of macromolecule metabolic process; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070585 protein localization to mitochondrion; GO:0070727 cellular macromolecule localization; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072594 establishment of protein localization to organelle; GO:0072655 establishment of protein localization to mitochondrion; GO:0072657 protein localization to membrane; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090150 establishment of protein localization to membrane; GO:0090151 establishment of protein localization to mitochondrial membrane; GO:0098657 import into cell; GO:1900034 regulation of cellular response to heat; GO:1903037 regulation of leukocyte cell-cell adhesion; GO:1903039 positive regulation of leukocyte cell-cell adhesion;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0030139 endocytic vesicle; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0031982 vesicle; GO:0031983 vesicle lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043230 extracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0060205 cytoplasmic vesicle lumen; GO:0070013 intracellular organelle lumen; GO:0070062 extracellular exosome; GO:0071682 endocytic vesicle lumen; GO:0097708 intracellular vesicle; GO:1903561 extracellular vesicle;","GO:0000166 nucleotide binding; GO:0000774 adenyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0017076 purine nucleotide binding; GO:0030234 enzyme regulator activity; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0060589 nucleoside-triphosphatase regulator activity; GO:0060590 ATPase regulator activity; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:0098772 molecular function regulator; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"O","KOG0103","Molecular chaperones HSP105/HSP110/SSE1"," HSP70 superfamily",{"$nulls":3},"R-HSA-2262752 Cellular responses to stress;R-HSA-3371453 Regulation of HSF1-mediated heat shock response;R-HSA-3371556 Cellular response to heat stress;R-HSA-8953897 Cellular responses to stimuli","https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-3371453;https://reactome.org/PathwayBrowser/#/R-HSA-3371556;https://reactome.org/PathwayBrowser/#/R-HSA-8953897","ESTROGEN RESPONSE LATE;P53 PATHWAY;SPERMATOGENESIS","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_LATE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_P53_PATHWAY;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_SPERMATOGENESIS"]
["P36915","Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2","GNL1",1.226776161,0.01281712,"nochange",31043.3,35229.3,36258.9,42527.9,41681.3,41574,0.815802925,0.925808982,0.952866373,1.117612664,1.095364425,1.092544632,"nucleus",{"$nulls":3},"GO:0002250 adaptive immune response; GO:0002252 immune effector process; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002449 lymphocyte mediated immunity; GO:0002456 T cell mediated immunity; GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; GO:0006950 response to stress; GO:0006955 immune response; GO:0006974 cellular response to DNA damage stimulus; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009987 cellular process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0023052 signaling; GO:0033554 cellular response to stress; GO:0042254 ribosome biogenesis; GO:0044085 cellular component biogenesis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis;","GO:0005576 extracellular region; GO:0005615 extracellular space;","GO:0000166 nucleotide binding; GO:0001882 nucleoside binding; GO:0001883 purine nucleoside binding; GO:0003824 catalytic activity; GO:0003924 GTPase activity; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0005525 GTP binding; GO:0016462 pyrophosphatase activity; GO:0016787 hydrolase activity; GO:0016817 hydrolase activity"," acting on acid anhydrides; GO:0016818 hydrolase activity"," acting on acid anhydrides"," in phosphorus-containing anhydrides; GO:0017076 purine nucleotide binding; GO:0017111 nucleoside-triphosphatase activity; GO:0019001 guanyl nucleotide binding; GO:0032549 ribonucleoside binding; GO:0032550 purine ribonucleoside binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032561 guanyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;",null,null,"R","KOG1424","Predicted GTP-binding protein MMR1"]
["P60983","Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2","GMFB",1.14533946,0.230257664,"nochange",12958.8,16061.9,13698.6,14389.9,18367.6,16170.6,0.84839068,1.051545379,0.896824132,0.942082372,1.202495652,1.058661784,"cytoplasm",{"$nulls":3},"GO:0000003 reproduction; GO:0001667 ameboidal-type cell migration; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0002064 epithelial cell development; GO:0002065 columnar/cuboidal epithelial cell differentiation; GO:0002066 columnar/cuboidal epithelial cell development; GO:0003006 developmental process involved in reproduction; GO:0003008 system process; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006469 negative regulation of protein kinase activity; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006928 movement of cell or subcellular component; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007297 ovarian follicle cell migration; GO:0007298 border follicle cell migration; GO:0007399 nervous system development; GO:0007610 behavior; GO:0007611 learning or memory; GO:0007612 learning; GO:0007626 locomotory behavior; GO:0008064 regulation of actin polymerization or depolymerization; GO:0008152 metabolic process; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010631 epithelial cell migration; GO:0010639 negative regulation of organelle organization; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016477 cell migration; GO:0019220 regulation of phosphate metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0019953 sexual reproduction; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0023052 signaling; GO:0030029 actin filament-based process; GO:0030154 cell differentiation; GO:0030707 ovarian follicle cell development; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030855 epithelial cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031344 regulation of cell projection organization; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032271 regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0032535 regulation of cellular component size; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0033043 regulation of organelle organization; GO:0033673 negative regulation of kinase activity; GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation; GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation; GO:0036211 protein modification process; GO:0040011 locomotion; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0043085 positive regulation of catalytic activity; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043254 regulation of protein-containing complex assembly; GO:0043412 macromolecule modification; GO:0043549 regulation of kinase activity; GO:0044087 regulation of cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044703 multi-organism reproductive process; GO:0045859 regulation of protein kinase activity; GO:0045936 negative regulation of phosphate metabolic process; GO:0048468 cell development; GO:0048477 oogenesis; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048609 multicellular organismal reproductive process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050794 regulation of cellular process; GO:0050877 nervous system process; GO:0050890 cognition; GO:0050896 response to stimulus; GO:0051014 actin filament severing; GO:0051125 regulation of actin nucleation; GO:0051126 negative regulation of actin nucleation; GO:0051128 regulation of cellular component organization; GO:0051129 negative regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051179 localization; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051493 regulation of cytoskeleton organization; GO:0051494 negative regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0071846 actin filament debranching; GO:0080090 regulation of primary metabolic process; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0110053 regulation of actin filament organization; GO:1901564 organonitrogen compound metabolic process; GO:1902903 regulation of supramolecular fiber organization; GO:1902904 negative regulation of supramolecular fiber organization;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0030027 lamellipodium; GO:0031252 cell leading edge; GO:0042995 cell projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0071944 cell periphery; GO:0120025 plasma membrane bounded cell projection;","GO:0004857 enzyme inhibitor activity; GO:0004860 protein kinase inhibitor activity; GO:0008047 enzyme activator activity; GO:0019207 kinase regulator activity; GO:0019210 kinase inhibitor activity; GO:0019887 protein kinase regulator activity; GO:0030234 enzyme regulator activity; GO:0098772 molecular function regulator;","PF00241","PF00241 Cofilin/tropomyosin-type actin-binding protein","W","KOG1736","Glia maturation factor beta",{"$nulls":5},"COMPLEMENT","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_COMPLEMENT"]
["Q13442","28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1","PDAP1",1.083859426,0.003312528,"nochange",78668.8,79838.6,81295.1,88124,86110.5,85677.7,0.944564569,0.958610183,0.976098162,1.058091747,1.033915952,1.028719387,"nucleus",{"$nulls":3},"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0008283 cell population proliferation; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0023052 signaling; GO:0032940 secretion by cell; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0048008 platelet-derived growth factor receptor signaling pathway; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0005515 protein binding; GO:0019838 growth factor binding; GO:0048407 platelet-derived growth factor binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF10252","PF10252 Casein kinase substrate phosphoprotein PP28","R","KOG3375","Phosphoprotein/predicted coiled-coil protein",{"$nulls":3},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695","MTORC1 SIGNALING;UV RESPONSE UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_UV_RESPONSE_UP"]
["Q2VPB7","AP-5 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP5B1 PE=1 SV=4","AP5B1",0.71621109,0.051599294,"nochange",6205.08,6143.16,7158.9,5783.81,4032.44,4154.98,1.112075648,1.100978333,1.283019454,1.036575556,0.722694683,0.744656326,"mitochondria","K19022",null,null,"GO:0006810 transport; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0046907 intracellular transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0016020 membrane; GO:0030117 membrane coat; GO:0030119 AP-type membrane coat adaptor complex; GO:0032991 protein-containing complex; GO:0048475 coated membrane; GO:0098796 membrane protein complex;"]
["Q58FF7","Putative heat shock protein HSP 90-beta-3 OS=Homo sapiens OX=9606 GN=HSP90AB3P PE=5 SV=1","HSP90AB3P",1.525556695,0.147134712,"nochange",7024.07,6013.28,12176.2,11109,10944,16411.7,0.661833829,0.56659346,1.147286554,1.046731027,1.031184117,1.546371014,"cytoplasm",{"$nulls":3},"GO:0000003 reproduction; GO:0000226 microtubule cytoskeleton organization; GO:0000578 embryonic axis specification; GO:0001568 blood vessel development; GO:0001654 eye development; GO:0001745 compound eye morphogenesis; GO:0001751 compound eye photoreceptor cell differentiation; GO:0001752 compound eye photoreceptor fate commitment; GO:0001754 eye photoreceptor cell differentiation; GO:0001817 regulation of cytokine production; GO:0001818 negative regulation of cytokine production; GO:0001944 vasculature development; GO:0002376 immune system process; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006403 RNA localization; GO:0006457 protein folding; GO:0006606 protein import into nucleus; GO:0006607 NLS-bearing protein import into nucleus; GO:0006810 transport; GO:0006886 intracellular protein transport; GO:0006913 nucleocytoplasmic transport; GO:0006928 movement of cell or subcellular component; GO:0006950 response to stress; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007028 cytoplasm organization; GO:0007049 cell cycle; GO:0007098 centrosome cycle; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007167 enzyme linked receptor protein signaling pathway; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007316 pole plasm RNA localization; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0007399 nervous system development; GO:0007423 sensory organ development; GO:0007465 R7 cell fate commitment; GO:0008104 protein localization; GO:0008285 negative regulation of cell population proliferation; GO:0008293 torso signaling pathway; GO:0008298 intracellular mRNA localization; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009266 response to temperature stimulus; GO:0009408 response to heat; GO:0009409 response to cold; GO:0009628 response to abiotic stimulus; GO:0009631 cold acclimation; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009887 animal organ morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010468 regulation of gene expression; GO:0010528 regulation of transposition; GO:0010529 negative regulation of transposition; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010564 regulation of cell cycle process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010948 negative regulation of cell cycle process; GO:0015031 protein transport; GO:0015833 peptide transport; GO:0016043 cellular component organization; GO:0016477 cell migration; GO:0017015 regulation of transforming growth factor beta receptor signaling pathway; GO:0017038 protein import; GO:0019094 pole plasm mRNA localization; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030162 regulation of proteolysis; GO:0030182 neuron differentiation; GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway; GO:0031023 microtubule organizing center organization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0033365 protein localization to organelle; GO:0033554 cellular response to stress; GO:0034504 protein localization to nucleus; GO:0034605 cellular response to heat; GO:0034613 cellular protein localization; GO:0035282 segmentation; GO:0040011 locomotion; GO:0042127 regulation of cell population proliferation; GO:0042176 regulation of protein catabolic process; GO:0042177 negative regulation of protein catabolic process; GO:0042706 eye photoreceptor cell fate commitment; GO:0042749 regulation of circadian sleep/wake cycle; GO:0042752 regulation of circadian rhythm; GO:0042886 amide transport; GO:0043248 proteasome assembly; GO:0043627 response to estrogen; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044703 multi-organism reproductive process; GO:0045165 cell fate commitment; GO:0045184 establishment of protein localization; GO:0045187 regulation of circadian sleep/wake cycle"," sleep; GO:0045466 R7 cell differentiation; GO:0045786 negative regulation of cell cycle; GO:0045787 positive regulation of cell cycle; GO:0045861 negative regulation of proteolysis; GO:0046530 photoreceptor cell differentiation; GO:0046552 photoreceptor cell fate commitment; GO:0046907 intracellular transport; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048592 eye morphogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048663 neuron fate commitment; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048749 compound eye development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050795 regulation of behavior; GO:0050896 response to stimulus; GO:0050900 leukocyte migration; GO:0051169 nuclear transport; GO:0051170 import into nucleus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0051674 localization of cell; GO:0051716 cellular response to stimulus; GO:0051726 regulation of cell cycle; GO:0060255 regulation of macromolecule metabolic process; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0061136 regulation of proteasomal protein catabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0071634 regulation of transforming growth factor beta production; GO:0071635 negative regulation of transforming growth factor beta production; GO:0071702 organic substance transport; GO:0071705 nitrogen compound transport; GO:0071840 cellular component organization or biogenesis; GO:0072359 circulatory system development; GO:0072594 establishment of protein localization to organelle; GO:0080090 regulation of primary metabolic process; GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0090287 regulation of cellular response to growth factor stimulus; GO:0090596 sensory organ morphogenesis; GO:1901388 regulation of transforming growth factor beta activation; GO:1901389 negative regulation of transforming growth factor beta activation; GO:1901799 negative regulation of proteasomal protein catabolic process; GO:1903050 regulation of proteolysis involved in cellular protein catabolic process; GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process; GO:1903362 regulation of cellular protein catabolic process; GO:1903363 negative regulation of cellular protein catabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903844 regulation of cellular response to transforming growth factor beta stimulus; GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus; GO:2000058 regulation of ubiquitin-dependent protein catabolic process; GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005667 transcription regulator complex; GO:0005694 chromosome; GO:0005700 polytene chromosome; GO:0005705 polytene chromosome interband; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0032991 protein-containing complex; GO:0034751 aryl hydrocarbon receptor complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043235 receptor complex; GO:0048471 perinuclear region of cytoplasm; GO:0098687 chromosomal region;","GO:0005488 binding; GO:0005515 protein binding; GO:0019904 protein domain specific binding; GO:0030911 TPR domain binding; GO:0046983 protein dimerization activity; GO:0051082 unfolded protein binding;","PF02518","PF02518 Histidine kinase-"," DNA gyrase B-"," and HSP90-like ATPase","O","KOG0019","Molecular chaperone (HSP90 family)"]
["Q5QJ74","Tubulin-specific chaperone cofactor E-like protein OS=Homo sapiens OX=9606 GN=TBCEL PE=1 SV=2","TBCEL",0.864197668,0.270460378,"nochange",6522.43,5271.6,6254.85,4724.28,4597.14,6276.38,1.163103759,0.940051143,1.115387908,0.842451023,0.81977895,1.119227216,"cytoplasm","nucleus","K22449",{"$nulls":5},"PF14560","PF14560 Ubiquitin-like domain","S","KOG2982","Uncharacterized conserved protein"]
["Q69YU5","Protein BRAWNIN OS=Homo sapiens OX=9606 GN=BRAWNIN PE=1 SV=2","BRAWNIN",1.563959944,0.028006133,"nochange",5533.72,6709.14,6776.7,11596.8,10231.8,7917.23,0.680858289,0.82547971,0.833792163,1.426848017,1.258901036,0.974120785,"extracellular"]
["Q6PJ69","Tripartite motif-containing protein 65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3","TRIM65",0.683036572,9.779477E-3,"down",11107.1,12560.5,10798.9,6811.96,8307.67,8422.25,1.148844357,1.299174361,1.116966204,0.704583717,0.859289985,0.871141376,"nucleus","K12031",null,null,"GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0010506 regulation of autophagy; GO:0010508 positive regulation of autophagy; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031329 regulation of cellular catabolic process; GO:0031331 positive regulation of cellular catabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",null,"PF00097; PF00643","PF00097 Zinc finger"," C3HC4 type (RING finger); PF00643 B-box zinc finger","O","KOG2177","Predicted E3 ubiquitin ligase"]
["Q6ZS81","WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3","WDFY4",0.606673346,0.000592019,"down",10407.6,10680,11050.7,5902.88,6694.46,6900.11,1.209348174,1.241000663,1.284075471,0.685906179,0.777886639,0.801782873,"plasma membrane","K24777",{"$nulls":5},"PF14844","PF14844 PH domain associated with Beige/BEACH","S","KOG1788","Uncharacterized conserved protein"]
["Q86UA1","Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3","PRPF39",2.021918719,{"v":4.53538e-05,"d":"4.54E-05"},"up",17769.5,17196.6,19457.7,36810.7,36838.9,36390.9,0.648268348,0.627367763,0.709857398,1.342930958,1.343959753,1.32761578,"cytoplasm","K13217",null,null,"GO:0000245 spliceosomal complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000381 regulation of alternative mRNA splicing"," via spliceosome; GO:0000395 mRNA 5'-splice site recognition; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006376 mRNA splice site selection; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0031323 regulation of cellular metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043484 regulation of RNA splicing; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0045292 mRNA cis splicing"," via spliceosome; GO:0046483 heterocycle metabolic process; GO:0048024 regulation of mRNA splicing"," via spliceosome; GO:0050684 regulation of mRNA processing; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:1903311 regulation of mRNA metabolic process;","GO:0000243 commitment complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005681 spliceosomal complex; GO:0005684 U2-type spliceosomal complex; GO:0005685 U1 snRNP; GO:0030532 small nuclear ribonucleoprotein complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071004 U2-type prespliceosome; GO:0071010 prespliceosome; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"A","KOG1258","mRNA processing protein"]
["Q86Y22","Collagen alpha-1(XXIII) chain OS=Homo sapiens OX=9606 GN=COL23A1 PE=1 SV=1","COL23A1",0.572071841,0.009659267,"down",3407.56,2978.72,2572.42,1902.09,1423.49,1799.44,1.451701681,1.269005632,1.09591216,0.810335622,0.606440628,0.766604278,"plasma membrane","K24355","COL23A; collagen type XXIII alpha","hsa04974 Protein digestion and absorption","GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0065003 protein-containing complex assembly; GO:0070206 protein trimerization; GO:0070207 protein homotrimerization; GO:0071840 cellular component organization or biogenesis;","GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005788 endoplasmic reticulum lumen; GO:0005886 plasma membrane; GO:0009986 cell surface; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031974 membrane-enclosed lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0071944 cell periphery;","GO:0005488 binding; GO:0005515 protein binding; GO:0005539 glycosaminoglycan binding; GO:0008201 heparin binding; GO:0042802 identical protein binding; GO:0042803 protein homodimerization activity; GO:0043167 ion binding; GO:0043168 anion binding; GO:0046983 protein dimerization activity; GO:0097367 carbohydrate derivative binding; GO:1901681 sulfur compound binding;",null,null,"W","KOG3544","Collagens (type IV and type XIII)"," and related proteins",{"$nulls":3},"R-HSA-1442490 Collagen degradation;R-HSA-1474228 Degradation of the extracellular matrix;R-HSA-1474244 Extracellular matrix organization;R-HSA-1474290 Collagen formation;R-HSA-1650814 Collagen biosynthesis and modifying enzymes;R-HSA-216083 Integrin cell surface interactions;R-HSA-8948216 Collagen chain trimerization","https://reactome.org/PathwayBrowser/#/R-HSA-1442490;https://reactome.org/PathwayBrowser/#/R-HSA-1474228;https://reactome.org/PathwayBrowser/#/R-HSA-1474244;https://reactome.org/PathwayBrowser/#/R-HSA-1474290;https://reactome.org/PathwayBrowser/#/R-HSA-1650814;https://reactome.org/PathwayBrowser/#/R-HSA-216083;https://reactome.org/PathwayBrowser/#/R-HSA-8948216"]
["Q8N0Z8","tRNA pseudouridine synthase-like 1 OS=Homo sapiens OX=9606 GN=PUSL1 PE=1 SV=1","PUSL1",0.813264442,0.05964824,"nochange",12350.7,10055.8,9742.76,8356.81,8832,8957.04,1.271190671,1.034989041,1.002769529,0.860121201,0.909029934,0.921899624,"mitochondria",{"$nulls":3},"GO:0001522 pseudouridine synthesis; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006400 tRNA modification; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0031119 tRNA pseudouridine synthesis; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0009982 pseudouridine synthase activity; GO:0016853 isomerase activity; GO:0016866 intramolecular transferase activity;","PF01416","PF01416 tRNA pseudouridine synthase","AJ","KOG4393","Predicted pseudouridylate synthase"]
["Q8NBF6","Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1","AVL9",0.663019196,1.157101E-3,"down",15121.5,13062.3,13106,9311.72,9021.36,9042.85,1.32131414,1.141381589,1.145200087,0.813656536,0.788284928,0.79016272,"nucleus",{"$nulls":3},"GO:0006928 movement of cell or subcellular component; GO:0009987 cellular process; GO:0016477 cell migration; GO:0040011 locomotion; GO:0048870 cell motility; GO:0051179 localization; GO:0051674 localization of cell;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0012505 endomembrane system; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0055037 recycling endosome; GO:0097708 intracellular vesicle;",{"$nulls":3},"S","KOG3823","Uncharacterized conserved protein",{"$nulls":5},"KRAS SIGNALING UP","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_KRAS_SIGNALING_UP"]
["Q8NFI3","Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1","ENGASE",0.88206631,0.342102388,"nochange",6239.19,4978.4,6302.34,6096.01,4514.46,4843.27,1.135304017,0.905886424,1.146795003,1.109250502,0.82146634,0.881297714,"mitochondria","K01227","ENGASE; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96]","hsa00511 Other glycan degradation","GO:0000270 peptidoglycan metabolic process; GO:0005975 carbohydrate metabolic process; GO:0006022 aminoglycan metabolic process; GO:0006026 aminoglycan catabolic process; GO:0006027 glycosaminoglycan catabolic process; GO:0006457 protein folding; GO:0006464 cellular protein modification process; GO:0006517 protein deglycosylation; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009057 macromolecule catabolic process; GO:0009100 glycoprotein metabolic process; GO:0009253 peptidoglycan catabolic process; GO:0009605 response to external stimulus; GO:0009607 response to biotic stimulus; GO:0009617 response to bacterium; GO:0009987 cellular process; GO:0016052 carbohydrate catabolic process; GO:0019538 protein metabolic process; GO:0030203 glycosaminoglycan metabolic process; GO:0035821 modulation of process of another organism; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043207 response to external biotic stimulus; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044278 cell wall disruption in another organism; GO:0044419 biological process involved in interspecies interaction between organisms; GO:0050896 response to stimulus; GO:0051707 response to other organism; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process; GO:1901136 carbohydrate derivative catabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901565 organonitrogen compound catabolic process; GO:1901575 organic substance catabolic process;","GO:0000323 lytic vacuole; GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005764 lysosome; GO:0005773 vacuole; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004553 hydrolase activity"," hydrolyzing O-glycosyl compounds; GO:0004563 beta-N-acetylhexosaminidase activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0015929 hexosaminidase activity; GO:0016231 beta-N-acetylglucosaminidase activity; GO:0016787 hydrolase activity; GO:0016798 hydrolase activity"," acting on glycosyl bonds; GO:0017022 myosin binding; GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity;",null,null,"R","KOG2331","Predicted glycosylhydrolase",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle;R-HSA-597592 Post-translational protein modification","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-532668;https://reactome.org/PathwayBrowser/#/R-HSA-597592"]
["Q8TCC3","39S ribosomal protein L30"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1","MRPL30",0.331856388,0.008558446,"down",3669.16,3212.13,5239.67,1232.76,978.868,1810.79,1.363714583,1.193850506,1.94742513,0.458179199,0.363815306,0.673015276,"cytoplasm","K02907","RP-L30; large subunit ribosomal protein L30","hsa03010 Ribosome","GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000315 organellar large ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005762 mitochondrial large ribosomal subunit; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;",null,"PF00327","PF00327 Ribosomal protein L30p/L7e","J","KOG4799","Mitochondrial ribosomal protein L30",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q8WVL7","Ankyrin repeat domain-containing protein 49 OS=Homo sapiens OX=9606 GN=ANKRD49 PE=1 SV=1","ANKRD49",0.72978674,0.178794703,"nochange",3340.89,3542.3,3536.95,3527.99,1634.45,2442.04,1.112108882,1.179153846,1.177372949,1.174390362,0.544072496,0.812901465,"cytoplasm","K21439",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"K","KOG0512","Fetal globin-inducing factor (contains ankyrin repeats)"]
["Q96FV2","Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3","SCRN2",0.810178018,0.069287265,"nochange",13494.2,11707.1,10559.1,9559.2,10458.5,8954.59,1.250762173,1.08511789,0.978711065,0.886031463,0.969386565,0.829990844,"extracellular","K14358",null,null,"GO:0006810 transport; GO:0006887 exocytosis; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0032940 secretion by cell; GO:0046903 secretion; GO:0051179 localization; GO:0051234 establishment of localization;"]
["Q96GE9","Distal membrane-arm assembly complex protein 1 OS=Homo sapiens OX=9606 GN=DMAC1 PE=1 SV=1","DMAC1",2.378553653,0.00620123,"up",3532.16,1996.99,2752.82,6137.43,6975.15,6586.53,0.757403217,0.42821578,0.590288867,1.316052847,1.495685656,1.412353633,"cytoplasm",{"$nulls":3},"GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0009987 cellular process; GO:0010257 NADH dehydrogenase complex assembly; GO:0016043 cellular component organization; GO:0022607 cellular component assembly; GO:0032981 mitochondrial respiratory chain complex I assembly; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0065003 protein-containing complex assembly; GO:0071840 cellular component organization or biogenesis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",null,"PF15055","PF15055 Domain of unknown function (DUF4536)",{"$nulls":3},"WP4324 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM","http://www.wikipathways.org/instance/WP4324_r98172"]
["Q9BPX5","Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1","ARPC5L",1.001414632,0.945382051,"nochange",48366.7,54918.4,54494.4,52615.2,53298.6,52088.9,0.918988467,1.043473635,1.035417449,0.999711827,1.012696726,0.989711896,"nucleus","K05754","ARPC5; actin related protein 2/3 complex"," subunit 5","hsa04666 Fc gamma R-mediated phagocytosis; hsa04530 Tight junction; hsa05131 Shigellosis; hsa05100 Bacterial invasion of epithelial cells; hsa05132 Salmonella infection; hsa04810 Regulation of actin cytoskeleton; hsa05130 Pathogenic Escherichia coli infection; hsa04144 Endocytosis; hsa05135 Yersinia infection","GO:0000902 cell morphogenesis; GO:0001667 ameboidal-type cell migration; GO:0002009 morphogenesis of an epithelium; GO:0006928 movement of cell or subcellular component; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007015 actin filament organization; GO:0007275 multicellular organism development; GO:0008064 regulation of actin polymerization or depolymerization; GO:0009653 anatomical structure morphogenesis; GO:0009790 embryo development; GO:0009888 tissue development; GO:0009987 cellular process; GO:0010631 epithelial cell migration; GO:0010638 positive regulation of organelle organization; GO:0016043 cellular component organization; GO:0016331 morphogenesis of embryonic epithelium; GO:0016477 cell migration; GO:0030029 actin filament-based process; GO:0030036 actin cytoskeleton organization; GO:0030832 regulation of actin filament length; GO:0030833 regulation of actin filament polymerization; GO:0030838 positive regulation of actin filament polymerization; GO:0031334 positive regulation of protein-containing complex assembly; GO:0032271 regulation of protein polymerization; GO:0032273 positive regulation of protein polymerization; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032535 regulation of cellular component size; GO:0032956 regulation of actin cytoskeleton organization; GO:0032970 regulation of actin filament-based process; GO:0032989 cellular component morphogenesis; GO:0033043 regulation of organelle organization; GO:0034314 Arp2/3 complex-mediated actin nucleation; GO:0040011 locomotion; GO:0043254 regulation of protein-containing complex assembly; GO:0044087 regulation of cellular component biogenesis; GO:0044089 positive regulation of cellular component biogenesis; GO:0045010 actin nucleation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048598 embryonic morphogenesis; GO:0048729 tissue morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048870 cell motility; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051179 localization; GO:0051493 regulation of cytoskeleton organization; GO:0051495 positive regulation of cytoskeleton organization; GO:0051674 localization of cell; GO:0060429 epithelium development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071840 cellular component organization or biogenesis; GO:0090066 regulation of anatomical structure size; GO:0090130 tissue migration; GO:0090132 epithelium migration; GO:0097435 supramolecular fiber organization; GO:0110053 regulation of actin filament organization; GO:1902903 regulation of supramolecular fiber organization; GO:1902905 positive regulation of supramolecular fiber organization;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005885 Arp2/3 protein complex; GO:0015629 actin cytoskeleton; GO:0030027 lamellipodium; GO:0031252 cell leading edge; GO:0032991 protein-containing complex; GO:0042995 cell projection; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0120025 plasma membrane bounded cell projection;","GO:0003779 actin binding; GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0044877 protein-containing complex binding; GO:0051015 actin filament binding;","PF04699","PF04699 ARP2/3 complex 16 kDa subunit (p16-Arc)","Z","KOG3380","Actin-related protein Arp2/3 complex"," subunit ARPC5","WP2272 PATHOGENIC ESCHERICHIA COLI INFECTION;WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP2272_r118427;http://www.wikipathways.org/instance/WP3888_r116782",{"$nulls":3},"MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["Q9BXK1","Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1","KLF16",1.056711583,0.93508108,"nochange",1211.66,1146.8,"NA",1783.16,709.052,"NA",0.999168775,0.945683402,"NA",1.470443683,0.58470414,"NA","nucleus","K09208",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007186 G protein-coupled receptor signaling pathway; GO:0007212 dopamine receptor signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0001227 DNA-binding transcription repressor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor"]
["Q9BYD6","39S ribosomal protein L1"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2","MRPL1",1.177529832,0.066464239,"nochange",30248.6,27430.8,32340.4,33187.4,38464.1,34349.5,0.925879294,0.839629264,0.989907194,1.015833014,1.177347506,1.051403729,"mitochondria","K02863","RP-L1; large subunit ribosomal protein L1","hsa03010 Ribosome","GO:0000154 rRNA modification; GO:0000469 cleavage involved in rRNA processing; GO:0000470 maturation of LSU-rRNA; GO:0001522 pseudouridine synthesis; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0016073 snRNA metabolic process; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0031118 rRNA pseudouridine synthesis; GO:0031120 snRNA pseudouridine synthesis; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0040031 snRNA modification; GO:0042254 ribosome biogenesis; GO:0042273 ribosomal large subunit biogenesis; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0140053 mitochondrial gene expression; GO:1901360 organic cyclic compound metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000315 organellar large ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005732 sno(s)RNA-containing ribonucleoprotein complex; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005762 mitochondrial large ribosomal subunit; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031429 box H/ACA snoRNP complex; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0072588 box H/ACA RNP complex; GO:0098798 mitochondrial protein-containing complex; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0030515 snoRNA binding; GO:0034513 box H/ACA snoRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF00687","PF00687 Ribosomal protein L1p/L10e family","J","KOG1569","50S ribosomal protein L1",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q9GZT6","Coiled-coil domain-containing protein 90B"," mitochondrial OS=Homo sapiens OX=9606 GN=CCDC90B PE=1 SV=2","CCDC90B",0.900119427,0.543941541,"nochange",4672.04,4226.76,3292.76,2890.78,3470.93,4612.15,1.210089867,1.094759344,0.852847045,0.748731514,0.898994277,1.194577953,"mitochondria",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"S","KOG3156","Uncharacterized membrane protein"]
["Q9H446","RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1","RWDD1",0.868714267,0.134904947,"nochange",17465.3,19892.2,18753.7,18014,16429.7,14300.9,0.999389638,1.138260354,1.073113743,1.030787043,0.940131113,0.818318109,"cytoplasm",{"$nulls":3},"GO:0002181 cytoplasmic translation; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006412 translation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007568 aging; GO:0007569 cell aging; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010469 regulation of signaling receptor activity; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0014070 response to organic cyclic compound; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030518 intracellular steroid hormone receptor signaling pathway; GO:0030521 androgen receptor signaling pathway; GO:0030522 intracellular receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032502 developmental process; GO:0032870 cellular response to hormone stimulus; GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway; GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway; GO:0033554 cellular response to stress; GO:0033574 response to testosterone; GO:0033993 response to lipid; GO:0034599 cellular response to oxidative stress; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0042221 response to chemical; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043401 steroid hormone mediated signaling pathway; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051091 positive regulation of DNA-binding transcription factor activity; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0060765 regulation of androgen receptor signaling pathway; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071383 cellular response to steroid hormone stimulus; GO:0071394 cellular response to testosterone stimulus; GO:0071396 cellular response to lipid; GO:0071407 cellular response to organic cyclic compound; GO:0071495 cellular response to endogenous stimulus; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901654 response to ketone; GO:1901655 cellular response to ketone; GO:1901700 response to oxygen-containing compound; GO:1901701 cellular response to oxygen-containing compound; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000273 positive regulation of signaling receptor activity; GO:2000825 positive regulation of androgen receptor activity; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005844 polysome; GO:0032991 protein-containing complex; GO:1990904 ribonucleoprotein complex;",null,"PF05773","PF05773 RWD domain","S","KOG4018","Uncharacterized conserved protein"," contains RWD domain"]
["Q9HCI6","E3 SUMO-protein ligase KIAA1586 OS=Homo sapiens OX=9606 GN=KIAA1586 PE=1 SV=2","KIAA1586",1.043865097,0.805714243,"nochange",1446.16,1033.26,"NA",1388.54,"NA",1199.64,1.141494988,0.81558134,"NA",1.096013892,"NA",0.94690978,"cytoplasm",{"$nulls":3},"GO:0006464 cellular protein modification process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016925 protein sumoylation; GO:0018193 peptidyl-amino acid modification; GO:0018205 peptidyl-lysine modification; GO:0019538 protein metabolic process; GO:0032446 protein modification by small protein conjugation; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0070647 protein modification by small protein conjugation or removal; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process;",null,"GO:0003824 catalytic activity; GO:0016740 transferase activity; GO:0019787 ubiquitin-like protein transferase activity; GO:0019789 SUMO transferase activity; GO:0061659 ubiquitin-like protein ligase activity; GO:0061665 SUMO ligase activity; GO:0140096 catalytic activity"," acting on a protein;",null,null,"R","KOG1721","FOG: Zn-finger"]
["Q9NTX5","Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2","ECHDC1",0.865254439,0.001262575,"down",69575.8,66266.8,66353.3,57722.7,58009.1,59219.1,1.106876155,1.054233524,1.055609646,0.918306081,0.922862397,0.942112196,"cytoplasm","K18426","ECHDC1; ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase [EC:4.1.1.94 4.1.1.-]","hsa00640 Propanoate metabolism; hsa01100 Metabolic pathways","GO:0006082 organic acid metabolic process; GO:0006629 lipid metabolic process; GO:0006631 fatty acid metabolic process; GO:0006635 fatty acid beta-oxidation; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009062 fatty acid catabolic process; GO:0009987 cellular process; GO:0016042 lipid catabolic process; GO:0016054 organic acid catabolic process; GO:0019395 fatty acid oxidation; GO:0019752 carboxylic acid metabolic process; GO:0030258 lipid modification; GO:0032787 monocarboxylic acid metabolic process; GO:0034440 lipid oxidation; GO:0043436 oxoacid metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044242 cellular lipid catabolic process; GO:0044248 cellular catabolic process; GO:0044255 cellular lipid metabolic process; GO:0044281 small molecule metabolic process; GO:0044282 small molecule catabolic process; GO:0046395 carboxylic acid catabolic process; GO:0071704 organic substance metabolic process; GO:0072329 monocarboxylic acid catabolic process; GO:1901575 organic substance catabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0003824 catalytic activity; GO:0004300 enoyl-CoA hydratase activity; GO:0016829 lyase activity; GO:0016830 carbon-carbon lyase activity; GO:0016831 carboxy-lyase activity; GO:0016835 carbon-oxygen lyase activity; GO:0016836 hydro-lyase activity;","PF00378","PF00378 Enoyl-CoA hydratase/isomerase","I","KOG1680","Enoyl-CoA hydratase","WP357 FATTY ACID BIOSYNTHESIS","http://www.wikipathways.org/instance/WP357_r117722"]
["Q9NVS2","39S ribosomal protein S18a"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1","MRPS18A",0.833550956,0.082849671,"nochange",44235.7,42275.2,46440.9,35554.1,42497,32771,1.088772014,1.040518284,1.143048538,0.875092042,1.045977441,0.806591682,"mitochondria","K02963","RP-S18; small subunit ribosomal protein S18","hsa03010 Ribosome","GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000314 organellar small ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005763 mitochondrial small ribosomal subunit; GO:0005829 cytosol; GO:0005840 ribosome; GO:0015935 small ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0022626 cytosolic ribosome; GO:0022627 cytosolic small ribosomal subunit; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;",null,null,"J","KOG3162","Mitochondrial/chloroplast ribosomal protein S18",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q9NYM9","BET1-like protein OS=Homo sapiens OX=9606 GN=BET1L PE=1 SV=1","BET1L",0.787285808,0.128750734,"nochange",6102.78,7153.77,5128.26,4677.4,4251.5,5545.2,1.114360762,1.306270354,0.936414507,0.854087978,0.776319117,1.012547282,"cytoplasm","K08504","BET1; blocked early in transport 1","hsa04130 SNARE interactions in vesicular transport","GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016192 vesicle-mediated transport; GO:0016197 endosomal transport; GO:0016482 cytosolic transport; GO:0032879 regulation of localization; GO:0042147 retrograde transport"," endosome to Golgi; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051641 cellular localization; GO:0051649 establishment of localization in cell; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0061025 membrane fusion; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:2000156 regulation of retrograde vesicle-mediated transport"," Golgi to ER;","GO:0000139 Golgi membrane; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005768 endosome; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005802 trans-Golgi network; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0030173 integral component of Golgi membrane; GO:0031090 organelle membrane; GO:0031201 SNARE complex; GO:0031224 intrinsic component of membrane; GO:0031228 intrinsic component of Golgi membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0032588 trans-Golgi network membrane; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment; GO:0098796 membrane protein complex;","GO:0005484 SNAP receptor activity; GO:0005488 binding; GO:0005515 protein binding;",null,null,"U","KOG3385","V-SNARE",{"$nulls":3},"R-HSA-199977 ER to Golgi Anterograde Transport;R-HSA-199991 Membrane Trafficking;R-HSA-392499 Metabolism of proteins;R-HSA-446203 Asparagine N-linked glycosylation;R-HSA-5653656 Vesicle-mediated transport;R-HSA-597592 Post-translational protein modification;R-HSA-6807878 COPI-mediated anterograde transport;R-HSA-6811438 Intra-Golgi traffic;R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic;R-HSA-948021 Transport to the Golgi and subsequent modification","https://reactome.org/PathwayBrowser/#/R-HSA-199977;https://reactome.org/PathwayBrowser/#/R-HSA-199991;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-446203;https://reactome.org/PathwayBrowser/#/R-HSA-5653656;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-6807878;https://reactome.org/PathwayBrowser/#/R-HSA-6811438;https://reactome.org/PathwayBrowser/#/R-HSA-6811442;https://reactome.org/PathwayBrowser/#/R-HSA-948021"]
["Q9P015","39S ribosomal protein L15"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1","MRPL15",0.995176415,0.963846176,"nochange",31100.6,27790.4,24905.6,29016.9,29773.1,24602.4,1.116123668,0.997328772,0.893800429,1.041344825,1.068482974,0.882919331,"cytoplasm","K02876","RP-L15; large subunit ribosomal protein L15","hsa03010 Ribosome","GO:0000002 mitochondrial genome maintenance; GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0042221 response to chemical; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor;","GO:0000313 organellar ribosome; GO:0000315 organellar large ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005762 mitochondrial large ribosomal subunit; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;",null,null,"J","KOG0846","Mitochondrial/chloroplast ribosomal protein L15/L10",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766","ADIPOGENESIS;OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ADIPOGENESIS;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["Q9UH62","Armadillo repeat-containing X-linked protein 3 OS=Homo sapiens OX=9606 GN=ARMCX3 PE=1 SV=1","ARMCX3",1.603962766,{"v":5.35962E-5,"d":"5.36E-05"},"up",20554.2,19572.6,20871,32527.3,33630.8,31680.1,0.776431036,0.739351281,0.788398096,1.228712634,1.270397139,1.196709814,"mitochondria","K26189",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0008104 protein localization; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0033036 macromolecule localization; GO:0034613 cellular protein localization; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051641 cellular localization; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070727 cellular macromolecule localization; GO:0080090 regulation of primary metabolic process; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031306 intrinsic component of mitochondrial outer membrane; GO:0031307 integral component of mitochondrial outer membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098573 intrinsic component of mitochondrial membrane; GO:0098588 bounding membrane of organelle;",{"$nulls":9},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013404 RAC2 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013404;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q9UMY1","Nucleolar protein 7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2","NOL7",0.710783541,0.003115557,"down",20037.2,21070,21657.9,15206.7,13502.2,15903.5,1.119631208,1.177341622,1.210192079,0.849714326,0.754470909,0.888649857,"nucleus",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",null,"PF08157","PF08157 NUC129 domain"]
["Q9Y5U8","Mitochondrial pyruvate carrier 1 OS=Homo sapiens OX=9606 GN=MPC1 PE=1 SV=1","MPC1",0.616147773,0.083127253,"nochange",2730.84,1452.49,2099.27,1158.64,1496.95,1215.42,1.613715713,0.858309508,1.240506578,0.684666833,0.884581937,0.718219431,"cytoplasm","K22138","MPC1; mitochondrial pyruvate carrier 1","hsa05415 Diabetic cardiomyopathy","GO:0006082 organic acid metabolic process; GO:0006084 acetyl-CoA metabolic process; GO:0006085 acetyl-CoA biosynthetic process; GO:0006086 acetyl-CoA biosynthetic process from pyruvate; GO:0006090 pyruvate metabolic process; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006637 acyl-CoA metabolic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006790 sulfur compound metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006811 ion transport; GO:0006820 anion transport; GO:0006839 mitochondrial transport; GO:0006848 pyruvate transport; GO:0006850 mitochondrial pyruvate transmembrane transport; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009165 nucleotide biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0015711 organic anion transport; GO:0015718 monocarboxylic acid transport; GO:0015849 organic acid transport; GO:0018130 heterocycle biosynthetic process; GO:0019362 pyridine nucleotide metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0032787 monocarboxylic acid metabolic process; GO:0033865 nucleoside bisphosphate metabolic process; GO:0033866 nucleoside bisphosphate biosynthetic process; GO:0033875 ribonucleoside bisphosphate metabolic process; GO:0034030 ribonucleoside bisphosphate biosynthetic process; GO:0034032 purine nucleoside bisphosphate metabolic process; GO:0034033 purine nucleoside bisphosphate biosynthetic process; GO:0034097 response to cytokine; GO:0034220 ion transmembrane transport; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035383 thioester metabolic process; GO:0035384 thioester biosynthetic process; GO:0042221 response to chemical; GO:0043436 oxoacid metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044272 sulfur compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0046496 nicotinamide nucleotide metabolic process; GO:0046942 carboxylic acid transport; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0055085 transmembrane transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071616 acyl-CoA biosynthetic process; GO:0071702 organic substance transport; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0072524 pyridine-containing compound metabolic process; GO:0090407 organophosphate biosynthetic process; GO:0098656 anion transmembrane transport; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901475 pyruvate transmembrane transport; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1903825 organic acid transmembrane transport; GO:1905039 carboxylic acid transmembrane transport; GO:1990542 mitochondrial transmembrane transport; GO:1990823 response to leukemia inhibitory factor; GO:1990830 cellular response to leukemia inhibitory factor;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0016020 membrane; GO:0016021 integral component of membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031224 intrinsic component of membrane; GO:0031300 intrinsic component of organelle membrane; GO:0031301 integral component of organelle membrane; GO:0031304 intrinsic component of mitochondrial inner membrane; GO:0031305 integral component of mitochondrial inner membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0032592 integral component of mitochondrial membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0098573 intrinsic component of mitochondrial membrane;","GO:0005215 transporter activity; GO:0005342 organic acid transmembrane transporter activity; GO:0008028 monocarboxylic acid transmembrane transporter activity; GO:0008509 anion transmembrane transporter activity; GO:0008514 organic anion transmembrane transporter activity; GO:0015075 ion transmembrane transporter activity; GO:0015318 inorganic molecular entity transmembrane transporter activity; GO:0022857 transmembrane transporter activity; GO:0046943 carboxylic acid transmembrane transporter activity; GO:0050833 pyruvate transmembrane transporter activity;",null,null,"S","KOG1590","Uncharacterized conserved protein","WP534 GLYCOLYSIS AND GLUCONEOGENESIS","http://www.wikipathways.org/instance/WP534_r117147",null,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport;R-HSA-1430728 Metabolism;R-HSA-70268 Pyruvate metabolism;R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle","https://reactome.org/PathwayBrowser/#/R-HSA-1428517;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-70268;https://reactome.org/PathwayBrowser/#/R-HSA-71406","OXIDATIVE PHOSPHORYLATION","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_OXIDATIVE_PHOSPHORYLATION"]
["A6NDR6","Putative homeobox protein Meis3-like 1 OS=Homo sapiens OX=9606 GN=MEIS3P1 PE=5 SV=2","MEIS3P1",0.876452794,0.162219028,"nochange",23757.8,23150.7,28859.3,21396.6,23333.8,21676.5,1.002617203,0.976996611,1.217908672,0.902970782,0.984723724,0.91478301,"nucleus",{"$nulls":3},"GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009893 positive regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010628 positive regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010941 regulation of cell death; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0023057 negative regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0032774 RNA biosynthetic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0042981 regulation of apoptotic process; GO:0043066 negative regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043069 negative regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045893 positive regulation of transcription"," DNA-templated; GO:0045935 positive regulation of nucleobase-containing compound metabolic process; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051254 positive regulation of RNA metabolic process; GO:0051896 regulation of protein kinase B signaling; GO:0051897 positive regulation of protein kinase B signaling; GO:0060255 regulation of macromolecule metabolic process; GO:0060548 negative regulation of cell death; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction; GO:1902680 positive regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903508 positive regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001234 negative regulation of apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0001228 DNA-binding transcription activator activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0043565 sequence-specific DNA binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;",null,null,"K","KOG0773","Transcription factor MEIS1 and related HOX domain proteins",null,null,"Transcription factor"]
["P58511","Small integral membrane protein 11 OS=Homo sapiens OX=9606 GN=SMIM11 PE=1 SV=1","SMIM11",0.99890941,0.98425102,"nochange",551.223,664.938,"NA",702.177,552.662,567.413,0.907090313,1.094219252,"NA",1.155499598,0.909458326,0.933732511,"extracellular"]
["Q15269","Periodic tryptophan protein 2 homolog OS=Homo sapiens OX=9606 GN=PWP2 PE=1 SV=2","PWP2",0.88374154,0.008468231,"down",51513,55117.6,52581.9,47104,48074.1,45524.6,1.030551303,1.102663686,1.051935347,0.94234637,0.961753856,0.910749439,"mitochondria","K14558","PWP2; periodic tryptophan protein 2","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000028 ribosomal small subunit assembly; GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0006996 organelle organization; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0030490 maturation of SSU-rRNA; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042255 ribosome assembly; GO:0042274 ribosomal small subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0065003 protein-containing complex assembly; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0030684 preribosome; GO:0030686 90S preribosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032040 small-subunit processome; GO:0032991 protein-containing complex; GO:0034388 Pwp2p-containing subcomplex of 90S preribosome; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0030515 snoRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG0291","WD40-repeat-containing subunit of the 18S rRNA processing complex",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q2M296","Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2","MTHFSD",0.517464459,0.007680911,"down",10078.6,9976.8,9944.67,4466.64,6667.79,4389.54,1.328344321,1.314927234,1.310692548,0.588696434,0.878804693,0.57853477,"nucleus","K24991",null,null,"GO:0000003 reproduction; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0000578 embryonic axis specification; GO:0003002 regionalization; GO:0003006 developmental process involved in reproduction; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006403 RNA localization; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007028 cytoplasm organization; GO:0007275 multicellular organism development; GO:0007276 gamete generation; GO:0007277 pole cell development; GO:0007281 germ cell development; GO:0007292 female gamete generation; GO:0007308 oocyte construction; GO:0007309 oocyte axis specification; GO:0007314 oocyte anterior/posterior axis specification; GO:0007315 pole plasm assembly; GO:0007316 pole plasm RNA localization; GO:0007350 blastoderm segmentation; GO:0007351 tripartite regional subdivision; GO:0007389 pattern specification process; GO:0008152 metabolic process; GO:0008298 intracellular mRNA localization; GO:0008358 maternal determination of anterior/posterior axis"," embryo; GO:0008380 RNA splicing; GO:0008595 anterior/posterior axis specification"," embryo; GO:0009790 embryo development; GO:0009798 axis specification; GO:0009880 embryonic pattern specification; GO:0009948 anterior/posterior axis specification; GO:0009952 anterior/posterior pattern specification; GO:0009987 cellular process; GO:0009994 oocyte differentiation; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0019094 pole plasm mRNA localization; GO:0019953 sexual reproduction; GO:0021700 developmental maturation; GO:0022412 cellular process involved in reproduction in multicellular organism; GO:0022414 reproductive process; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0033036 macromolecule localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0035282 segmentation; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044703 multi-organism reproductive process; GO:0045451 pole plasm oskar mRNA localization; GO:0046483 heterocycle metabolic process; GO:0048468 cell development; GO:0048469 cell maturation; GO:0048477 oogenesis; GO:0048599 oocyte development; GO:0048609 multicellular organismal reproductive process; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0051179 localization; GO:0051641 cellular localization; GO:0060810 intracellular mRNA localization involved in pattern specification process; GO:0060811 intracellular mRNA localization involved in anterior/posterior axis specification; GO:0070727 cellular macromolecule localization; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0032991 protein-containing complex; GO:1990904 ribonucleoprotein complex;",null,"PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","H","KOG4410","5-formyltetrahydrofolate cyclo-ligase"]
["Q5JQS6","Germinal center-associated signaling and motility-like protein OS=Homo sapiens OX=9606 GN=GCSAML PE=1 SV=1","GCSAML",1.096436936,0.216408292,"nochange",5722.85,7126.47,6099.54,6860.33,7039.82,6876.08,0.864368086,1.076368109,0.921262608,1.036170843,1.063280662,1.038549692,"nucleus"]
["Q5THK1","Protein PRR14L OS=Homo sapiens OX=9606 GN=PRR14L PE=1 SV=1","PRR14L",0.848426483,0.272867669,"nochange",1447.56,1527.13,1739.59,1143.08,1523.4,"NA",0.980630721,1.034534384,1.178462652,0.7743647,1.032007544,"NA","nucleus"]
["Q6PCB5","Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2","RSBN1L",1.030672292,0.741205305,"nochange",8508.59,10805.3,10939.8,10846.5,10973.2,9361.94,0.830980154,1.055285289,1.068421053,1.059309033,1.07168302,0.91432145,"nucleus","K22610",{"$nulls":7},"S","KOG4425","Uncharacterized conserved protein"]
["Q86V88","Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1","MDP1",0.61794102,{"v":3.96174e-05,"d":"3.96E-05"},"down",12251,11437.2,12252.9,7440.69,7279.95,7488.84,1.264063058,1.18009485,1.264259101,0.767733357,0.75114814,0.772701493,"cytoplasm","K17619",null,null,"GO:0006040 amino sugar metabolic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0016311 dephosphorylation; GO:0030389 fructosamine metabolic process; GO:0044237 cellular metabolic process; GO:0071704 organic substance metabolic process; GO:1901135 carbohydrate derivative metabolic process;",null,"GO:0003824 catalytic activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016791 phosphatase activity; GO:0042578 phosphoric ester hydrolase activity;",null,null,"R","KOG4549","Magnesium-dependent phosphatase"]
["Q8IXT5","RNA-binding protein 12B OS=Homo sapiens OX=9606 GN=RBM12B PE=1 SV=2","RBM12B",1.335930658,0.000639496,"up",17393.8,18504.1,18452.9,23374.8,24022.6,25211.5,0.822015175,0.874486943,0.872067278,1.104671797,1.135286236,1.19147257,"extracellular","K24526",{"$nulls":5},"PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)","R","KOG4307","RNA binding protein RBM12/SWAN"]
["Q8N3Z3","GTP-binding protein 8 OS=Homo sapiens OX=9606 GN=GTPBP8 PE=1 SV=1","GTPBP8",1.25470505,0.008581351,"up",9228.48,10034.3,8704.51,12169.9,11224.1,11696.7,0.878094592,0.954768777,0.828238578,1.157972209,1.067978856,1.112946987,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"R","KOG2486","Predicted GTPase"]
["Q8N8D1","Programmed cell death protein 7 OS=Homo sapiens OX=9606 GN=PDCD7 PE=1 SV=1","PDCD7",1.154367136,0.205615306,"nochange",5680.27,5534.89,5507.7,7537.21,5550.84,6216.27,0.945997439,0.921785718,0.917257471,1.25525395,0.924442046,1.035263376,"nucleus",{"$nulls":3},"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0010941 regulation of cell death; GO:0010942 positive regulation of cell death; GO:0014070 response to organic cyclic compound; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0031960 response to corticosteroid; GO:0033993 response to lipid; GO:0034641 cellular nitrogen compound metabolic process; GO:0042221 response to chemical; GO:0042981 regulation of apoptotic process; GO:0043065 positive regulation of apoptotic process; GO:0043067 regulation of programmed cell death; GO:0043068 positive regulation of programmed cell death; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048545 response to steroid hormone; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051384 response to glucocorticoid; GO:0065007 biological regulation; GO:0070228 regulation of lymphocyte apoptotic process; GO:0070230 positive regulation of lymphocyte apoptotic process; GO:0070232 regulation of T cell apoptotic process; GO:0070234 positive regulation of T cell apoptotic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process; GO:2000106 regulation of leukocyte apoptotic process; GO:2000108 positive regulation of leukocyte apoptotic process; GO:2001233 regulation of apoptotic signaling pathway; GO:2001235 positive regulation of apoptotic signaling pathway;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0005689 U12-type spliceosomal complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;",{"$nulls":9},"R-HSA-72165 mRNA Splicing - Minor Pathway;R-HSA-72172 mRNA Splicing;R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-72165;https://reactome.org/PathwayBrowser/#/R-HSA-72172;https://reactome.org/PathwayBrowser/#/R-HSA-72203;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q8TD55","Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1","PLEKHO2",1.396614662,2.03403E-4,"up",10736.6,10621.2,10940.3,15679.7,14419.1,15009.2,0.832228985,0.823283953,0.848018438,1.215384834,1.117671605,1.163412186,"nucleus","K24022",null,null,"GO:0001775 cell activation; GO:0002252 immune effector process; GO:0002263 cell activation involved in immune response; GO:0002274 myeloid leukocyte activation; GO:0002275 myeloid cell activation involved in immune response; GO:0002283 neutrophil activation involved in immune response; GO:0002366 leukocyte activation involved in immune response; GO:0002376 immune system process; GO:0002443 leukocyte mediated immunity; GO:0002444 myeloid leukocyte mediated immunity; GO:0002446 neutrophil mediated immunity; GO:0006810 transport; GO:0006887 exocytosis; GO:0006955 immune response; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0032940 secretion by cell; GO:0036230 granulocyte activation; GO:0042119 neutrophil activation; GO:0043299 leukocyte degranulation; GO:0043312 neutrophil degranulation; GO:0045055 regulated exocytosis; GO:0045321 leukocyte activation; GO:0046903 secretion; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization;","GO:0005576 extracellular region; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0012505 endomembrane system; GO:0030141 secretory granule; GO:0031410 cytoplasmic vesicle; GO:0031974 membrane-enclosed lumen; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:0097708 intracellular vesicle; GO:0099503 secretory vesicle; GO:0101002 ficolin-1-rich granule; GO:1904813 ficolin-1-rich granule lumen;",null,"PF00169","PF00169 PH domain",{"$nulls":6},"R-HSA-168249 Innate Immune System;R-HSA-168256 Immune System;R-HSA-6798695 Neutrophil degranulation","https://reactome.org/PathwayBrowser/#/R-HSA-168249;https://reactome.org/PathwayBrowser/#/R-HSA-168256;https://reactome.org/PathwayBrowser/#/R-HSA-6798695"]
["Q96CS4","Zinc finger protein 689 OS=Homo sapiens OX=9606 GN=ZNF689 PE=1 SV=1","ZNF689",0.556074536,0.055279757,"nochange",2089.41,2544.74,1975.82,799.746,1726.54,1149.35,1.218835332,1.484447295,1.152573801,0.466523411,1.007158936,0.670461225,"nucleus","K09228","KRAB; KRAB domain-containing zinc finger protein","hsa05168 Herpes simplex virus 1 infection","GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007275 multicellular organism development; GO:0007517 muscle organ development; GO:0007519 skeletal muscle tissue development; GO:0009888 tissue development; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0014706 striated muscle tissue development; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0030154 cell differentiation; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035914 skeletal muscle cell differentiation; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0060537 muscle tissue development; GO:0060538 skeletal muscle organ development; GO:0061061 muscle structure development; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;",null,"GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",{"$nulls":3},"R-HSA-212436 Generic Transcription Pathway;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["Q96H79","Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2","ZC3HAV1L",1.152970045,0.146603116,"nochange",11065.9,11355.5,13155.5,14695.2,12165.8,14158.1,0.866825944,0.889511202,1.030510732,1.151120163,0.95298449,1.10904747,"extracellular",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;",null,"PF18606","PF18606 Zap  helix turn helix N-terminal domain"]
["Q99676","Zinc finger protein 184 OS=Homo sapiens OX=9606 GN=ZNF184 PE=1 SV=4","ZNF184",1.016580776,0.68287902,"nochange",5103.27,4773.14,5482.34,5146.3,5176.14,5290.97,0.98861752,0.924663956,1.062051856,0.996953393,1.002734068,1.024979207,"nucleus","K09228","KRAB; KRAB domain-containing zinc finger protein","hsa05168 Herpes simplex virus 1 infection","GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0001894 tissue homeostasis; GO:0001932 regulation of protein phosphorylation; GO:0001933 negative regulation of protein phosphorylation; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0001960 negative regulation of cytokine-mediated signaling pathway; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002761 regulation of myeloid leukocyte differentiation; GO:0002762 negative regulation of myeloid leukocyte differentiation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006366 transcription by RNA polymerase II; GO:0006469 negative regulation of protein kinase activity; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007166 cell surface receptor signaling pathway; GO:0007249 I-kappaB kinase/NF-kappaB signaling; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009653 anatomical structure morphogenesis; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009966 regulation of signal transduction; GO:0009968 negative regulation of signal transduction; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010467 gene expression; GO:0010468 regulation of gene expression; GO:0010528 regulation of transposition; GO:0010529 negative regulation of transposition; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010563 negative regulation of phosphorus metabolic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0010646 regulation of cell communication; GO:0010648 negative regulation of cell communication; GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway; GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway; GO:0016070 RNA metabolic process; GO:0018130 heterocycle biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019220 regulation of phosphate metabolic process; GO:0019221 cytokine-mediated signaling pathway; GO:0019222 regulation of metabolic process; GO:0019438 aromatic compound biosynthetic process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023057 negative regulation of signaling; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0031399 regulation of protein modification process; GO:0031400 negative regulation of protein modification process; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0032268 regulation of cellular protein metabolic process; GO:0032269 negative regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032774 RNA biosynthetic process; GO:0032872 regulation of stress-activated MAPK cascade; GO:0032873 negative regulation of stress-activated MAPK cascade; GO:0033673 negative regulation of kinase activity; GO:0034097 response to cytokine; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0035107 appendage morphogenesis; GO:0035108 limb morphogenesis; GO:0035556 intracellular signal transduction; GO:0042221 response to chemical; GO:0042325 regulation of phosphorylation; GO:0042326 negative regulation of phosphorylation; GO:0042592 homeostatic process; GO:0043086 negative regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043392 negative regulation of DNA binding; GO:0043405 regulation of MAP kinase activity; GO:0043407 negative regulation of MAP kinase activity; GO:0043408 regulation of MAPK cascade; GO:0043409 negative regulation of MAPK cascade; GO:0043433 negative regulation of DNA-binding transcription factor activity; GO:0043506 regulation of JUN kinase activity; GO:0043508 negative regulation of JUN kinase activity; GO:0043549 regulation of kinase activity; GO:0044092 negative regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0045453 bone resorption; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045637 regulation of myeloid cell differentiation; GO:0045638 negative regulation of myeloid cell differentiation; GO:0045670 regulation of osteoclast differentiation; GO:0045671 negative regulation of osteoclast differentiation; GO:0045859 regulation of protein kinase activity; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0045936 negative regulation of phosphate metabolic process; GO:0046328 regulation of JNK cascade; GO:0046329 negative regulation of JNK cascade; GO:0046483 heterocycle metabolic process; GO:0046849 bone remodeling; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048585 negative regulation of response to stimulus; GO:0048736 appendage development; GO:0048771 tissue remodeling; GO:0048856 anatomical structure development; GO:0048871 multicellular organismal homeostasis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051052 regulation of DNA metabolic process; GO:0051053 negative regulation of DNA metabolic process; GO:0051090 regulation of DNA-binding transcription factor activity; GO:0051093 negative regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051101 regulation of DNA binding; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051174 regulation of phosphorus metabolic process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051248 negative regulation of protein metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051716 cellular response to stimulus; GO:0060173 limb development; GO:0060249 anatomical structure homeostasis; GO:0060255 regulation of macromolecule metabolic process; GO:0060759 regulation of response to cytokine stimulus; GO:0060761 negative regulation of response to cytokine stimulus; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0065009 regulation of molecular function; GO:0070302 regulation of stress-activated protein kinase signaling cascade; GO:0070303 negative regulation of stress-activated protein kinase signaling cascade; GO:0070887 cellular response to chemical stimulus; GO:0070894 regulation of transposon integration; GO:0070895 negative regulation of transposon integration; GO:0071310 cellular response to organic substance; GO:0071345 cellular response to cytokine stimulus; GO:0071704 organic substance metabolic process; GO:0071900 regulation of protein serine/threonine kinase activity; GO:0071901 negative regulation of protein serine/threonine kinase activity; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0080135 regulation of cellular response to stress; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902105 regulation of leukocyte differentiation; GO:1902106 negative regulation of leukocyte differentiation; GO:1902531 regulation of intracellular signal transduction; GO:1902532 negative regulation of intracellular signal transduction; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:1903706 regulation of hemopoiesis; GO:1903707 negative regulation of hemopoiesis; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2000659 regulation of interleukin-1-mediated signaling pathway; GO:2000660 negative regulation of interleukin-1-mediated signaling pathway; GO:2000677 regulation of transcription regulatory region DNA binding; GO:2000678 negative regulation of transcription regulatory region DNA binding; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005730 nucleolus; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0048471 perinuclear region of cytoplasm; GO:0070013 intracellular organelle lumen;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003682 chromatin binding; GO:0003690 double-stranded DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0003712 transcription coregulator activity; GO:0003714 transcription corepressor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0008270 zinc ion binding; GO:0019899 enzyme binding; GO:0031625 ubiquitin protein ligase binding; GO:0043167 ion binding; GO:0043169 cation binding; GO:0043565 sequence-specific DNA binding; GO:0044389 ubiquitin-like protein ligase binding; GO:0046872 metal ion binding; GO:0046914 transition metal ion binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger",null,null,"Transcription factor","R-HSA-212436 Generic Transcription Pathway;R-HSA-73857 RNA Polymerase II Transcription;R-HSA-74160 Gene expression (Transcription)","https://reactome.org/PathwayBrowser/#/R-HSA-212436;https://reactome.org/PathwayBrowser/#/R-HSA-73857;https://reactome.org/PathwayBrowser/#/R-HSA-74160"]
["Q9BRR8","G patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GPATCH1 PE=1 SV=1","GPATCH1",1.014511249,0.778267854,"nochange",5053.61,5372.7,5919.63,5412.07,5812.89,5358.18,0.920817101,0.978958416,1.078614404,0.986132015,1.059165333,0.97631273,"nucleus","K13123",null,null,"GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005681 spliceosomal complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0071013 catalytic step 2 spliceosome; GO:1902494 catalytic complex; GO:1990904 ribonucleoprotein complex;","GO:0005488 binding; GO:0005515 protein binding;",null,null,"A","KOG2138","Predicted RNA binding protein"," contains G-patch domain"]
["Q9H8U3","AN1-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=ZFAND3 PE=1 SV=1","ZFAND3",1.50775163,0.103908002,"nochange",2027.79,2633.38,"NA",4295.86,2921.89,3324.08,0.666904558,0.866072486,"NA",1.412832993,0.960958363,1.093231599,"extracellular","K24686",{"$nulls":7},"R","KOG3173","Predicted Zn-finger protein"]
["Q9H9L3","Interferon-stimulated 20 kDa exonuclease-like 2 OS=Homo sapiens OX=9606 GN=ISG20L2 PE=1 SV=1","ISG20L2",0.626038296,0.011654355,"nochange",5323.21,6069.32,6552.73,3992.48,3117.21,4124.73,1.094571976,1.247989012,1.347389005,0.82094389,0.640968647,0.848137471,"nucleus","K18329",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090503 RNA phosphodiester bond hydrolysis"," exonucleolytic; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000175 3'-5'-exoribonuclease activity; GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004527 exonuclease activity; GO:0004532 exoribonuclease activity; GO:0004540 ribonuclease activity; GO:0008408 3'-5' exonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0016796 exonuclease activity"," active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; GO:0016896 exoribonuclease activity"," producing 5'-phosphomonoesters; GO:0140098 catalytic activity"," acting on RNA;",null,null,"L","KOG2249","3'-5' exonuclease",{"$nulls":3},"R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","ESTROGEN RESPONSE EARLY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY"]
["Q9NXU5","ADP-ribosylation factor-like protein 15 OS=Homo sapiens OX=9606 GN=ARL15 PE=1 SV=1","ARL15",1.276591977,0.058728392,"nochange",4094.19,4506.27,5008.72,6510.71,5786.27,5076.39,0.79287018,0.87267252,0.96997568,1.260847154,1.120553989,0.983080476,"extracellular","K17201",{"$nulls":5},"PF00025","PF00025 ADP-ribosylation factor family","U","KOG0071","GTP-binding ADP-ribosylation factor Arf6 (dArf3)"]
["Q9UBI9","Headcase protein homolog OS=Homo sapiens OX=9606 GN=HECA PE=1 SV=1","HECA",1.171370694,0.203653106,"nochange",1971.57,2325.18,2851.38,2776.95,2947.53,2648.63,0.762144004,0.898837979,1.102249563,1.073477377,1.139417985,1.023873093,"nucleus","K23049",null,null,"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0001763 morphogenesis of a branching structure; GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0007275 multicellular organism development; GO:0007346 regulation of mitotic cell cycle; GO:0007399 nervous system development; GO:0007409 axonogenesis; GO:0007424 open tracheal system development; GO:0007430 terminal branching"," open tracheal system; GO:0007431 salivary gland development; GO:0007435 salivary gland morphogenesis; GO:0007552 metamorphosis; GO:0008219 cell death; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0009996 negative regulation of cell fate specification; GO:0010453 regulation of cell fate commitment; GO:0010454 negative regulation of cell fate commitment; GO:0010468 regulation of gene expression; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010608 posttranscriptional regulation of gene expression; GO:0010623 programmed cell death involved in cell development; GO:0010629 negative regulation of gene expression; GO:0010721 negative regulation of cell development; GO:0012501 programmed cell death; GO:0014041 regulation of neuron maturation; GO:0016043 cellular component organization; GO:0016049 cell growth; GO:0016246 RNA interference; GO:0016441 posttranscriptional gene silencing; GO:0019222 regulation of metabolic process; GO:0022008 neurogenesis; GO:0022612 gland morphogenesis; GO:0030030 cell projection organization; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0030323 respiratory tube development; GO:0031047 gene silencing by RNA; GO:0031175 neuron projection development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0035070 salivary gland histolysis; GO:0035071 salivary gland cell autophagic cell death; GO:0035146 tube fusion; GO:0035147 branch fusion"," open tracheal system; GO:0035155 negative regulation of terminal cell fate specification"," open tracheal system; GO:0035194 post-transcriptional gene silencing by RNA; GO:0035239 tube morphogenesis; GO:0035272 exocrine system development; GO:0035295 tube development; GO:0040007 growth; GO:0040029 regulation of gene expression"," epigenetic; GO:0042659 regulation of cell fate specification; GO:0045595 regulation of cell differentiation; GO:0045596 negative regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045786 negative regulation of cell cycle; GO:0045930 negative regulation of mitotic cell cycle; GO:0048102 autophagic cell death; GO:0048468 cell development; GO:0048513 animal organ development; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048588 developmental cell growth; GO:0048589 developmental growth; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048675 axon extension; GO:0048699 generation of neurons; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048732 gland development; GO:0048754 branching morphogenesis of an epithelial tube; GO:0048812 neuron projection morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050768 negative regulation of neurogenesis; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051093 negative regulation of developmental process; GO:0051239 regulation of multicellular organismal process; GO:0051241 negative regulation of multicellular organismal process; GO:0051726 regulation of cell cycle; GO:0051960 regulation of nervous system development; GO:0051961 negative regulation of nervous system development; GO:0060033 anatomical structure regression; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0060429 epithelium development; GO:0060446 branching involved in open tracheal system development; GO:0060541 respiratory system development; GO:0060560 developmental growth involved in morphogenesis; GO:0060562 epithelial tube morphogenesis; GO:0061138 morphogenesis of a branching epithelium; GO:0061564 axon development; GO:0065007 biological regulation; GO:0071840 cellular component organization or biogenesis; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1903429 regulation of cell maturation; GO:1904799 regulation of neuron remodeling; GO:1990138 neuron projection extension; GO:2000026 regulation of multicellular organismal development;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0030424 axon; GO:0030425 dendrite; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0048471 perinuclear region of cytoplasm; GO:0097447 dendritic tree; GO:0120025 plasma membrane bounded cell projection;",{"$nulls":3},"T","KOG3816","Cell differentiation regulator of the Headcase family"]
["Q9UFN0","Protein NipSnap homolog 3A OS=Homo sapiens OX=9606 GN=NIPSNAP3A PE=1 SV=2","NIPSNAP3A",1.344569882,{"v":3.70599e-06,"d":"3.71E-06"},"up",89045.7,88579,89936.7,120676,118245,120834,0.851682181,0.847218405,0.860204197,1.154211814,1.130960389,1.155723013,"mitochondria",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005829 cytosol; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",null,"PF07978","PF07978 NIPSNAP ","S","KOG2883","NIPSNAP1 protein"]
["Q9UG63","ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2","ABCF2",0.931723369,0.050930613,"nochange",28449.7,30724.7,29469.4,28223.7,27168.7,27199.1,0.99686338,1.076578252,1.032593163,0.988944452,0.951977776,0.953042977,"nucleus","K06185","ABCF2; ATP-binding cassette"," subfamily F"," member 2","hsa05130 Pathogenic Escherichia coli infection",null,"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0031967 organelle envelope; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;","GO:0000166 nucleotide binding; GO:0005215 transporter activity; GO:0005488 binding; GO:0005524 ATP binding; GO:0017076 purine nucleotide binding; GO:0030554 adenyl nucleotide binding; GO:0032553 ribonucleotide binding; GO:0032555 purine ribonucleotide binding; GO:0032559 adenyl ribonucleotide binding; GO:0035639 purine ribonucleoside triphosphate binding; GO:0036094 small molecule binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0097159 organic cyclic compound binding; GO:0097367 carbohydrate derivative binding; GO:1901265 nucleoside phosphate binding; GO:1901363 heterocyclic compound binding;","PF00005; PF12848","PF00005 ABC transporter; PF12848 ABC transporter","R","KOG0927","Predicted transporter (ABC superfamily)","WP3888 VEGFAVEGFR2 SIGNALING PATHWAY","http://www.wikipathways.org/instance/WP3888_r116782",{"$nulls":3},"MTORC1 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MTORC1_SIGNALING"]
["Q9UGV2","Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2","NDRG3",0.890912499,0.169833075,"nochange",41749.7,35993.3,38561.8,36868.7,30882.5,35866.2,1.139030985,0.981982719,1.0520575,1.005865711,0.842547956,0.978515129,"cytoplasm",{"$nulls":3},"GO:0000003 reproduction; GO:0001558 regulation of cell growth; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007276 gamete generation; GO:0007283 spermatogenesis; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0019953 sexual reproduction; GO:0022414 reproductive process; GO:0023051 regulation of signaling; GO:0023052 signaling; GO:0023056 positive regulation of signaling; GO:0030154 cell differentiation; GO:0030308 negative regulation of cell growth; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032504 multicellular organism reproduction; GO:0040008 regulation of growth; GO:0044703 multi-organism reproductive process; GO:0045926 negative regulation of growth; GO:0046578 regulation of Ras protein signal transduction; GO:0046579 positive regulation of Ras protein signal transduction; GO:0048232 male gamete generation; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048609 multicellular organismal reproductive process; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051057 positive regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:1902531 regulation of intracellular signal transduction; GO:1902533 positive regulation of intracellular signal transduction;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;",null,"PF03096","PF03096 Ndr family","S","KOG2931","Differentiation-related gene 1 protein (NDR1 protein)"," related proteins"]
["Q9UHA2","SS18-like protein 2 OS=Homo sapiens OX=9606 GN=SS18L2 PE=1 SV=1","SS18L2",0.863475273,0.259295861,"nochange",2980.77,4087.01,3632.04,2934.71,3432.19,2872.13,0.896973496,1.229863307,1.092953706,0.883113118,1.032814831,0.864281541,"extracellular",{"$nulls":8},"K","KOG3227","Calcium-responsive transcription coactivator"]
["Q9UI15","Transgelin-3 OS=Homo sapiens OX=9606 GN=TAGLN3 PE=1 SV=2","TAGLN3",0.862197899,0.182943676,"nochange",18542.7,22721,20168.6,20185.6,16945,15836.2,0.972526882,1.191670214,1.057802028,1.058693644,0.888730768,0.830576464,"cytoplasm","K20526",null,null,"GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0003008 system process; GO:0003012 muscle system process; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0006936 muscle contraction; GO:0006939 smooth muscle contraction; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0009719 response to endogenous stimulus; GO:0009725 response to hormone; GO:0009755 hormone-mediated signaling pathway; GO:0009889 regulation of biosynthetic process; GO:0009890 negative regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009987 cellular process; GO:0010033 response to organic substance; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010558 negative regulation of macromolecule biosynthetic process; GO:0010605 negative regulation of macromolecule metabolic process; GO:0010629 negative regulation of gene expression; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0023052 signaling; GO:0030522 intracellular receptor signaling pathway; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031327 negative regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032870 cellular response to hormone stimulus; GO:0035626 juvenile hormone mediated signaling pathway; GO:0042221 response to chemical; GO:0045892 negative regulation of transcription"," DNA-templated; GO:0045934 negative regulation of nucleobase-containing compound metabolic process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051172 negative regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0051253 negative regulation of RNA metabolic process; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0070887 cellular response to chemical stimulus; GO:0071310 cellular response to organic substance; GO:0071495 cellular response to endogenous stimulus; GO:0080090 regulation of primary metabolic process; GO:1902679 negative regulation of RNA biosynthetic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:1903507 negative regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2000113 negative regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0005856 cytoskeleton; GO:0005865 striated muscle thin filament; GO:0015629 actin cytoskeleton; GO:0030016 myofibril; GO:0030017 sarcomere; GO:0036379 myofilament; GO:0043209 myelin sheath; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043292 contractile fiber; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0000976 transcription cis-regulatory region binding; GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding; GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding; GO:0000987 cis-regulatory region sequence-specific DNA binding; GO:0001067 transcription regulatory region nucleic acid binding; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003690 double-stranded DNA binding; GO:0003779 actin binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008092 cytoskeletal protein binding; GO:0043565 sequence-specific DNA binding; GO:0070594 juvenile hormone response element binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding; GO:1990837 sequence-specific double-stranded DNA binding;","PF00307","PF00307 Calponin homology (CH) domain","Z","KOG2046","Calponin"]
["Q9UJC5","SH3 domain-binding glutamic acid-rich-like protein 2 OS=Homo sapiens OX=9606 GN=SH3BGRL2 PE=1 SV=2","SH3BGRL2",2.233971208,0.000899253,"up",3806,4245.7,4488.39,10245.1,7989.14,9779.96,0.563097024,0.628150561,0.664056503,1.515760725,1.181991844,1.446943344,"cytoplasm","K23740",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",{"$nulls":3},"S","KOG4023","Uncharacterized conserved protein",{"$nulls":5},"IL2 STAT5 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING"]
["Q9UJT0","Tubulin epsilon chain OS=Homo sapiens OX=9606 GN=TUBE1 PE=2 SV=1","TUBE1",0.638519234,0.205681604,"nochange",1792.53,3128.73,3352.97,1763.91,"NA",1758.26,0.759778407,1.326137635,1.421183581,0.747647587,"NA",0.745252789,"cytoskeleton","K10391",null,null,"GO:0000226 microtubule cytoskeleton organization; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007049 cell cycle; GO:0007098 centrosome cycle; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0022402 cell cycle process; GO:0031023 microtubule organizing center organization; GO:0071840 cellular component organization or biogenesis;","GO:0000242 pericentriolar material; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005813 centrosome; GO:0005815 microtubule organizing center; GO:0005856 cytoskeleton; GO:0015630 microtubule cytoskeleton; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle;","GO:0005198 structural molecule activity; GO:0005200 structural constituent of cytoskeleton;","PF00091; PF03953","PF00091 Tubulin/FtsZ family"," GTPase domain; PF03953 Tubulin C-terminal domain","Z","KOG1375","Beta tubulin","WP4536 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR","http://www.wikipathways.org/instance/WP4536_r110928"]
["Q9UKY7","Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1","CDV3",1.250538264,0.004289148,"up",24587.8,23791.3,24865.6,32718.3,29740.2,29136.8,0.894969668,0.865977918,0.905081291,1.190911187,1.082511526,1.060548411,"nucleus",{"$nulls":3},"GO:0008283 cell population proliferation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;"]
["Q9ULL1","Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens OX=9606 GN=PLEKHG1 PE=1 SV=2","PLEKHG1",1.021044844,0.952676915,"nochange",4128.92,3916.68,3146.69,3266.28,3300.51,4861.04,1.095198434,1.03890165,0.834661355,0.866382672,0.875462199,1.28939369,"nucleus","K23859",null,null,"GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0003002 regionalization; GO:0007275 multicellular organism development; GO:0007389 pattern specification process; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007474 imaginal disc-derived wing vein specification; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007478 leg disc morphogenesis; GO:0007480 imaginal disc-derived leg morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009966 regulation of signal transduction; GO:0010646 regulation of cell communication; GO:0023051 regulation of signaling; GO:0030100 regulation of endocytosis; GO:0032489 regulation of Cdc42 protein signal transduction; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0035023 regulation of Rho protein signal transduction; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035218 leg disc development; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0046578 regulation of Ras protein signal transduction; GO:0048513 animal organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048583 regulation of response to stimulus; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0050764 regulation of phagocytosis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051049 regulation of transport; GO:0051056 regulation of small GTPase mediated signal transduction; GO:0051128 regulation of cellular component organization; GO:0060099 regulation of phagocytosis"," engulfment; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0060627 regulation of vesicle-mediated transport; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:1901074 regulation of engulfment of apoptotic cell; GO:1902531 regulation of intracellular signal transduction; GO:1905153 regulation of membrane invagination; GO:2000425 regulation of apoptotic cell clearance;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0043292 contractile fiber; GO:0055120 striated muscle dense body; GO:0070013 intracellular organelle lumen; GO:0099080 supramolecular complex; GO:0099081 supramolecular polymer; GO:0099512 supramolecular fiber;","GO:0005085 guanyl-nucleotide exchange factor activity; GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0019904 protein domain specific binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding; GO:0098772 molecular function regulator;","PF00621","PF00621 RhoGEF domain","R","KOG3518","Putative guanine nucleotide exchange factor",{"$nulls":3},"R-HSA-162582 Signal Transduction;R-HSA-194315 Signaling by Rho GTPases;R-HSA-9012999 RHO GTPase cycle;R-HSA-9013148 CDC42 GTPase cycle;R-HSA-9013149 RAC1 GTPase cycle;R-HSA-9716542 Signaling by Rho GTPases"," Miro GTPases and RHOBTB3","https://reactome.org/PathwayBrowser/#/R-HSA-162582;https://reactome.org/PathwayBrowser/#/R-HSA-194315;https://reactome.org/PathwayBrowser/#/R-HSA-9012999;https://reactome.org/PathwayBrowser/#/R-HSA-9013148;https://reactome.org/PathwayBrowser/#/R-HSA-9013149;https://reactome.org/PathwayBrowser/#/R-HSA-9716542"]
["Q9UNX4","WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1","WDR3",0.935278847,0.182765855,"nochange",35357.7,31659.1,35331.5,30923.3,31872,32928.9,1.071053276,0.959015512,1.070259627,0.936726704,0.965464666,0.997480216,"cytoplasm","K14556","DIP2; U3 small nucleolar RNA-associated protein 12","hsa03008 Ribosome biogenesis in eukaryotes","GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030490 maturation of SSU-rRNA; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042274 ribosomal small subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0030684 preribosome; GO:0030686 90S preribosome; GO:0031090 organelle membrane; GO:0031965 nuclear membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0031981 nuclear lumen; GO:0032040 small-subunit processome; GO:0032991 protein-containing complex; GO:0034388 Pwp2p-containing subcomplex of 90S preribosome; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0005488 binding; GO:0030515 snoRNA binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"A","KOG0306","WD40-repeat-containing subunit of the 18S rRNA processing complex",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9Y291","28S ribosomal protein S33"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPS33 PE=1 SV=1","MRPS33",1.025443206,0.827986471,"nochange",11400.4,9912.07,18947,12914,16847.4,11522.4,0.83884789,0.729335726,1.394130993,0.950219436,1.239641236,0.847824719,"nucleus","K17411",null,null,"GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000314 organellar small ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005763 mitochondrial small ribosomal subunit; GO:0005840 ribosome; GO:0015935 small ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;",null,null,"T","KOG4104","Ganglioside-induced differentiation associated protein 3",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q9Y2G8","DnaJ homolog subfamily C member 16 OS=Homo sapiens OX=9606 GN=DNAJC16 PE=2 SV=3","DNAJC16",1.243544839,0.018025923,"nochange",4933.59,4876.02,5739.19,6235.66,6719.65,6380.32,0.848560232,0.838658393,0.987120615,1.072511719,1.155756307,1.097392734,"endoplasmic reticulum","K09536",{"$nulls":3},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol;",null,"PF00226; PF00085","PF00226 DnaJ domain; PF00085 Thioredoxin","O","KOG0715","Molecular chaperone (DnaJ superfamily)"]
["Q9Y2P8","RNA 3'-terminal phosphate cyclase-like protein OS=Homo sapiens OX=9606 GN=RCL1 PE=1 SV=3","RCL1",0.838110164,0.056407323,"nochange",23968.5,20141,23396.9,17603.9,18974,19999.9,1.158979145,0.973903204,1.131339848,0.851223605,0.91747378,0.967080418,"mitochondria","K11108","RCL1; RNA 3'-terminal phosphate cyclase-like protein","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000460 maturation of 5.8S rRNA; GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000469 cleavage involved in rRNA processing; GO:0000478 endonucleolytic cleavage involved in rRNA processing; GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030490 maturation of SSU-rRNA; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042274 ribosomal small subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090502 RNA phosphodiester bond hydrolysis"," endonucleolytic; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0003824 catalytic activity; GO:0004518 nuclease activity; GO:0004519 endonuclease activity; GO:0004521 endoribonuclease activity; GO:0004540 ribonuclease activity; GO:0016787 hydrolase activity; GO:0016788 hydrolase activity"," acting on ester bonds; GO:0140098 catalytic activity"," acting on RNA;","PF01137; PF05189","PF01137 RNA 3'-terminal phosphate cyclase; PF05189 RNA 3'-terminal phosphate cyclase (RTC)"," insert domain","A","KOG3980","RNA 3'-terminal phosphate cyclase",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854","HEME METABOLISM;MYC TARGETS V2","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_HEME_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_MYC_TARGETS_V2"]
["Q9Y2S6","Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1","TMA7",1.154598851,0.537053672,"nochange",2822.2,3408.31,3228.81,2579.07,3769.87,4572.78,0.830831008,1.003376668,0.950533437,0.759255661,1.109816771,1.346186456,"nucleus",{"$nulls":8},"S","KOG4766","Uncharacterized conserved protein"]
["Q9Y312","Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2","AAR2",1.686558428,0.017321884,"nochange",2671.73,2393.26,2110.51,4018.87,4818.4,3264.63,0.831563385,0.744890909,0.656886302,1.250854368,1.499704317,1.016100719,"cytoplasm","K13205",null,null,"GO:0000244 spliceosomal tri-snRNP complex assembly; GO:0000375 RNA splicing"," via transesterification reactions; GO:0000377 RNA splicing"," via transesterification reactions with bulged adenosine as nucleophile; GO:0000387 spliceosomal snRNP assembly; GO:0000398 mRNA splicing"," via spliceosome; GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006397 mRNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0008380 RNA splicing; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0016070 RNA metabolic process; GO:0016071 mRNA metabolic process; GO:0022607 cellular component assembly; GO:0022613 ribonucleoprotein complex biogenesis; GO:0022618 ribonucleoprotein complex assembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0043170 macromolecule metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0065003 protein-containing complex assembly; GO:0071704 organic substance metabolic process; GO:0071826 ribonucleoprotein complex subunit organization; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0030532 small nuclear ribonucleoprotein complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"A","KOG3937","mRNA splicing factor","WP4352 CILIARY LANDSCAPE","http://www.wikipathways.org/instance/WP4352_r102218"]
["Q9Y324","rRNA-processing protein FCF1 homolog OS=Homo sapiens OX=9606 GN=FCF1 PE=1 SV=1","FCF1",0.667731184,0.060680297,"nochange",10655,9353.87,13082.8,6023.48,6884.1,9188.76,1.158403791,1.016945891,1.422352428,0.654868331,0.748434307,0.998995253,"cytoplasm","K14566","UTP24; U3 small nucleolar RNA-associated protein 24","hsa03008 Ribosome biogenesis in eukaryotes","GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000460 maturation of 5.8S rRNA; GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000469 cleavage involved in rRNA processing; GO:0000478 endonucleolytic cleavage involved in rRNA processing; GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA"," 5.8S rRNA"," LSU-rRNA); GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0030490 maturation of SSU-rRNA; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042274 ribosomal small subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:0090305 nucleic acid phosphodiester bond hydrolysis; GO:0090501 RNA phosphodiester bond hydrolysis; GO:0090502 RNA phosphodiester bond hydrolysis"," endonucleolytic; GO:1901360 organic cyclic compound metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0030684 preribosome; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032040 small-subunit processome; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"R","KOG3165","Predicted nucleic-acid-binding protein"," contains PIN domain",{"$nulls":3},"R-HSA-6790901 rRNA modification in the nucleus and cytosol;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-72312 rRNA processing;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA","https://reactome.org/PathwayBrowser/#/R-HSA-6790901;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854"]
["Q9Y343","Sorting nexin-24 OS=Homo sapiens OX=9606 GN=SNX24 PE=1 SV=1","SNX24",1.597863124,0.412649346,"nochange",2111.01,399.305,850.292,2374.96,1204.9,"NA",1.52079824,0.28766436,0.612561086,1.710951151,0.868025163,"NA","cytoplasm","K17941",{"$nulls":4},"GO:0005488 binding; GO:0005543 phospholipid binding; GO:0008289 lipid binding; GO:0010314 phosphatidylinositol-5-phosphate binding; GO:0032266 phosphatidylinositol-3-phosphate binding; GO:0035091 phosphatidylinositol binding; GO:0043167 ion binding; GO:0043168 anion binding; GO:0070273 phosphatidylinositol-4-phosphate binding; GO:1901981 phosphatidylinositol phosphate binding;","PF00787","PF00787 PX domain","ZUD","KOG2101","Intermediate filament-like protein"," sorting nexins"," and related proteins containing PX (PhoX) domain(s)",{"$nulls":5},"ESTROGEN RESPONSE EARLY","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_ESTROGEN_RESPONSE_EARLY"]
["Q9Y3B9","RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2","RRP15",1.265743556,0.008740259,"up",32636.4,36094.7,37099.5,42134,45101.9,46718.5,0.816641575,0.903176596,0.928319119,1.054294472,1.1285585,1.169009738,"nucleus",{"$nulls":3},"GO:0000460 maturation of 5.8S rRNA; GO:0000470 maturation of LSU-rRNA; GO:0006139 nucleobase-containing compound metabolic process; GO:0006364 rRNA processing; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016072 rRNA metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0042254 ribosome biogenesis; GO:0042273 ribosomal large subunit biogenesis; GO:0043170 macromolecule metabolic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;","GO:0030684 preribosome; GO:0030687 preribosome"," large subunit precursor; GO:0032991 protein-containing complex; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"S","KOG2974","Uncharacterized conserved protein"]
["Q9Y3D5","28S ribosomal protein S18c"," mitochondrial OS=Homo sapiens OX=9606 GN=MRPS18C PE=1 SV=1","MRPS18C",1.233332468,0.057006681,"nochange",12146.6,12723.8,13671.6,15323.8,18000.5,14210.8,0.846678152,0.88691185,0.952978202,1.068144721,1.254723963,0.990563111,"extracellular","K02963","RP-S18; small subunit ribosomal protein S18","hsa03010 Ribosome","GO:0006412 translation; GO:0006414 translational elongation; GO:0006415 translational termination; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016043 cellular component organization; GO:0019538 protein metabolic process; GO:0022411 cellular component disassembly; GO:0032543 mitochondrial translation; GO:0032984 protein-containing complex disassembly; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0070125 mitochondrial translational elongation; GO:0070126 mitochondrial translational termination; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0140053 mitochondrial gene expression; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000313 organellar ribosome; GO:0000314 organellar small ribosomal subunit; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005743 mitochondrial inner membrane; GO:0005759 mitochondrial matrix; GO:0005761 mitochondrial ribosome; GO:0005763 mitochondrial small ribosomal subunit; GO:0005829 cytosol; GO:0005840 ribosome; GO:0015935 small ribosomal subunit; GO:0016020 membrane; GO:0019866 organelle inner membrane; GO:0022626 cytosolic ribosome; GO:0022627 cytosolic small ribosomal subunit; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0044391 ribosomal subunit; GO:0070013 intracellular organelle lumen; GO:0098798 mitochondrial protein-containing complex; GO:1990904 ribonucleoprotein complex;","GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity;",null,null,"J","KOG3162","Mitochondrial/chloroplast ribosomal protein S18",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5368286 Mitochondrial translation initiation;R-HSA-5368287 Mitochondrial translation;R-HSA-5389840 Mitochondrial translation elongation;R-HSA-5419276 Mitochondrial translation termination;R-HSA-72766 Translation","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5368286;https://reactome.org/PathwayBrowser/#/R-HSA-5368287;https://reactome.org/PathwayBrowser/#/R-HSA-5389840;https://reactome.org/PathwayBrowser/#/R-HSA-5419276;https://reactome.org/PathwayBrowser/#/R-HSA-72766"]
["Q9Y3P4","Rhomboid domain-containing protein 3 OS=Homo sapiens OX=9606 GN=RHBDD3 PE=2 SV=1","RHBDD3",0.727257733,0.082703021,"nochange",4141.55,2874.16,2806.53,2202.46,2502.8,2438.04,1.464692547,1.016469856,0.992551961,0.778917736,0.885135398,0.862232502,"plasma membrane",{"$nulls":3},"GO:0000165 MAPK cascade; GO:0001889 liver development; GO:0002673 regulation of acute inflammatory response; GO:0002682 regulation of immune system process; GO:0002683 negative regulation of immune system process; GO:0002694 regulation of leukocyte activation; GO:0002695 negative regulation of leukocyte activation; GO:0002791 regulation of peptide secretion; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0007275 multicellular organism development; GO:0008152 metabolic process; GO:0009410 response to xenobiotic stimulus; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009896 positive regulation of catabolic process; GO:0009987 cellular process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0016310 phosphorylation; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0023052 signaling; GO:0031347 regulation of defense response; GO:0032101 regulation of response to external stimulus; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032814 regulation of natural killer cell activation; GO:0032815 negative regulation of natural killer cell activation; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0035556 intracellular signal transduction; GO:0036211 protein modification process; GO:0042176 regulation of protein catabolic process; GO:0042221 response to chemical; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045732 positive regulation of protein catabolic process; GO:0048513 animal organ development; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048523 negative regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048731 system development; GO:0048732 gland development; GO:0048856 anatomical structure development; GO:0050708 regulation of protein secretion; GO:0050727 regulation of inflammatory response; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050865 regulation of cell activation; GO:0050866 negative regulation of cell activation; GO:0050896 response to stimulus; GO:0051046 regulation of secretion; GO:0051049 regulation of transport; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051223 regulation of protein transport; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051249 regulation of lymphocyte activation; GO:0051250 negative regulation of lymphocyte activation; GO:0051716 cellular response to stimulus; GO:0060255 regulation of macromolecule metabolic process; GO:0061008 hepaticobiliary system development; GO:0065007 biological regulation; GO:0070201 regulation of establishment of protein localization; GO:0071704 organic substance metabolic process; GO:0080090 regulation of primary metabolic process; GO:0080134 regulation of response to stress; GO:0090087 regulation of peptide transport; GO:1901564 organonitrogen compound metabolic process; GO:1903530 regulation of secretion by cell;",null,null,"PF00627","PF00627 UBA/TS-N domain","S","KOG2632","Rhomboid family proteins"]
["Q9Y3T6","R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3","R3HCC1",1.255134788,0.072291271,"nochange",13073.4,11256.1,14932.1,16457.2,17809.5,15011.9,0.885929781,0.762778941,1.011886126,1.115235791,1.206875521,1.017293839,"nucleus",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0032991 protein-containing complex; GO:0035145 exon-exon junction complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",null,"PF01424","PF01424 R3H domain","S","KOG4483","Uncharacterized conserved protein"]
["Q9Y426","C2 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=C2CD2 PE=1 SV=2","C2CD2",1.102420443,0.909106935,"nochange","NA",1499.75,1923.59,2500.03,"NA",1273.93,"NA",0.83350701,1.069062009,1.389426591,"NA",0.708004391,"extracellular",{"$nulls":6},"PF18696; PF00168","PF18696 Synaptotagmin-like"," mitochondrial and lipid-binding domain; PF00168 C2 domain"]
["Q9Y485","DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3","DMXL1",0.695753265,0.002931226,"down",30242.3,34131.2,34031.5,21597.8,22262.9,24604.9,1.087392267,1.227221572,1.223636758,0.776570588,0.800484927,0.884693889,"cytoplasm","K24155","DMXL; rabconnectin-3a","hsa04142 Lysosome","GO:0006873 cellular ion homeostasis; GO:0006885 regulation of pH; GO:0007035 vacuolar acidification; GO:0007275 multicellular organism development; GO:0007424 open tracheal system development; GO:0008593 regulation of Notch signaling pathway; GO:0009653 anatomical structure morphogenesis; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0016043 cellular component organization; GO:0019725 cellular homeostasis; GO:0022607 cellular component assembly; GO:0023051 regulation of signaling; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030641 regulation of cellular pH; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035148 tube formation; GO:0035149 lumen formation"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042592 homeostatic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0045851 pH reduction; GO:0048583 regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0051452 intracellular pH reduction; GO:0051453 regulation of intracellular pH; GO:0055067 monovalent inorganic cation homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0060541 respiratory system development; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0070070 proton-transporting V-type ATPase complex assembly; GO:0070071 proton-transporting two-sector ATPase complex assembly; GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly; GO:0071840 cellular component organization or biogenesis; GO:0098771 inorganic ion homeostasis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043291 RAVE complex; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0099503 secretory vesicle;","GO:0005488 binding; GO:0005515 protein binding; GO:0019899 enzyme binding; GO:0031267 small GTPase binding; GO:0051020 GTPase binding;",null,null,"R","KOG1064","RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein"," WD repeat superfamily"]
["Q9Y4E6","WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2","WDR7",1.031324951,0.600877273,"nochange",6540.32,6938.97,5670.62,6473.67,6645.75,6630.36,1.008797756,1.070286678,0.874652729,0.998517469,1.025059583,1.022685785,"peroxisome","K24738","WDR7; rabconnectin-3b","hsa04142 Lysosome","GO:0002244 hematopoietic progenitor cell differentiation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0006873 cellular ion homeostasis; GO:0006885 regulation of pH; GO:0007035 vacuolar acidification; GO:0007275 multicellular organism development; GO:0007424 open tracheal system development; GO:0008593 regulation of Notch signaling pathway; GO:0009653 anatomical structure morphogenesis; GO:0009966 regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0019725 cellular homeostasis; GO:0023051 regulation of signaling; GO:0030003 cellular cation homeostasis; GO:0030004 cellular monovalent inorganic cation homeostasis; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0030641 regulation of cellular pH; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0035148 tube formation; GO:0035149 lumen formation"," open tracheal system; GO:0035152 regulation of tube architecture"," open tracheal system; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0042592 homeostatic process; GO:0045851 pH reduction; GO:0048513 animal organ development; GO:0048534 hematopoietic or lymphoid organ development; GO:0048583 regulation of response to stimulus; GO:0048646 anatomical structure formation involved in morphogenesis; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0048878 chemical homeostasis; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050801 ion homeostasis; GO:0051452 intracellular pH reduction; GO:0051453 regulation of intracellular pH; GO:0055067 monovalent inorganic cation homeostasis; GO:0055080 cation homeostasis; GO:0055082 cellular chemical homeostasis; GO:0060541 respiratory system development; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0098771 inorganic ion homeostasis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0008021 synaptic vesicle; GO:0012505 endomembrane system; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0045202 synapse; GO:0070382 exocytic vesicle; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0099503 secretory vesicle;",{"$nulls":3},"R","KOG4155","FOG: WD40 repeat"]
["A1L170","Uncharacterized protein C1orf226 OS=Homo sapiens OX=9606 GN=C1orf226 PE=1 SV=1","C1orf226",0.822436636,0.17048952,"nochange",8873.58,7150.42,7931.73,7885.41,6297.72,5518.94,1.219518162,0.982699999,1.090077374,1.083711502,0.865511318,0.758481646,"nucleus",{"$nulls":8},"R","KOG4815","Muscular protein implicated in muscular dystrophy phenotype"]
["A6NI47","Putative POTE ankyrin domain family member M OS=Homo sapiens OX=9606 GN=POTEM PE=3 SV=2","POTEM",1.171974845,0.0349533,"nochange",65034.1,62316.3,55964.2,72355.7,68279.4,74205,0.980032636,0.939076696,0.843353601,1.090365629,1.028937747,1.118233692,"cytoplasm","K17299",{"$nulls":7},"Z","KOG0676","Actin and related proteins"]
["A8MTT3","Protein CEBPZOS OS=Homo sapiens OX=9606 GN=CEBPZOS PE=1 SV=2","CEBPZOS",1.901208184,0.002017607,"up",1992.74,1761.37,1552.2,3616.42,3451.88,3020.1,0.776658995,0.686483864,0.604961055,1.40947897,1.345350448,1.177066668,"extracellular"]
["C9J7I0","UBAP1-MVB12-associated (UMA)-domain containing protein 1 OS=Homo sapiens OX=9606 GN=UMAD1 PE=1 SV=2","UMAD1",1.609514936,0.455170046,"nochange","NA",390.985,1127.75,1286.95,1214.86,1164.83,"NA",0.377007449,1.087433406,1.240942073,1.17142926,1.123187812,"cytoplasm","nucleus"]
["H3BV12","Golgin subfamily A member 8Q OS=Homo sapiens OX=9606 GN=GOLGA8Q PE=3 SV=1","GOLGA8Q",0.992122975,0.873088196,"nochange",8081.64,7570.41,8001.55,6846.26,8060.38,8560.64,1.029052089,0.963956106,1.018854062,0.871748575,1.026345009,1.090044159,"nucleus",{"$nulls":3},"GO:0000003 reproduction; GO:0000212 meiotic spindle organization; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007020 microtubule nucleation; GO:0007030 Golgi organization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007098 centrosome cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008356 asymmetric cell division; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010560 positive regulation of glycoprotein biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031023 microtubule organizing center organization; GO:0031109 microtubule polymerization or depolymerization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032091 negative regulation of protein binding; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046785 microtubule polymerization; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048285 organelle fission; GO:0048308 organelle inheritance; GO:0048313 Golgi inheritance; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051258 protein polymerization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051262 protein tetramerization; GO:0051289 protein homotetramerization; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051438 regulation of ubiquitin-protein transferase activity; GO:0051443 positive regulation of ubiquitin-protein transferase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060049 regulation of protein glycosylation; GO:0060050 positive regulation of protein glycosylation; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070085 glycosylation; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090114 COPII-coated vesicle budding; GO:0090161 Golgi ribbon formation; GO:0090166 Golgi disassembly; GO:0090306 meiotic spindle assembly; GO:0090307 mitotic spindle assembly; GO:0097435 supramolecular fiber organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1900006 positive regulation of dendrite development; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903008 organelle disassembly; GO:1903018 regulation of glycoprotein metabolic process; GO:1903020 positive regulation of glycoprotein metabolic process; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1904666 regulation of ubiquitin protein ligase activity; GO:1904668 positive regulation of ubiquitin protein ligase activity; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0000137 Golgi cis cisterna; GO:0000139 Golgi membrane; GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005798 Golgi-associated vesicle; GO:0005801 cis-Golgi network; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030134 COPII-coated ER to Golgi transport vesicle; GO:0030135 coated vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0032580 Golgi cisterna membrane; GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0072686 mitotic spindle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0000149 SNARE binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019905 syntaxin binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0051020 GTPase binding; GO:0061676 importin-alpha family protein binding;",null,null,"S","KOG4725","Uncharacterized conserved protein"]
["L0R6Q1","SLC35A4 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=SLC35A4 PE=3 SV=1","SLC35A4",1.310140289,0.010306147,"nochange",14173.1,11757.2,12440.4,17173.2,17086.2,16011.6,0.959352088,0.795824087,0.842068688,1.162423555,1.156534678,1.083796904,"cytoplasm"]
["O75391","Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2","SPAG7",0.896940287,0.070052048,"nochange",96857.3,88432.9,90722.6,84189.8,86446.8,76930.4,1.109943126,1.013403114,1.039642095,0.964779008,0.99064326,0.881589397,"nucleus",{"$nulls":6},"PF01424","PF01424 R3H domain"]
["P0C7M6","IQ domain-containing protein F3 OS=Homo sapiens OX=9606 GN=IQCF3 PE=1 SV=1","IQCF3",1.268288368,0.284131398,"nochange",8604.52,6393.42,3937.73,8376.98,8255.29,7383.62,1.201984747,0.893111216,0.550070358,1.170199173,1.153200023,1.031434481,"cytoplasm","mitochondria","K24840",{"$nulls":4},"GO:0005488 binding; GO:0005515 protein binding; GO:0005516 calmodulin binding;"]
["P0CJ78","Zinc finger protein 865 OS=Homo sapiens OX=9606 GN=ZNF865 PE=1 SV=1","ZNF865",0.776292462,0.446650271,"nochange",2038.48,1614.61,3532.81,1856.49,2014.63,1707.24,0.95821301,0.758967617,1.66064151,0.872666336,0.94700202,0.802509507,"nucleus",{"$nulls":6},"PF00096; PF13912","PF00096 Zinc finger"," C2H2 type; PF13912 C2H2-type zinc finger","R","KOG1721","FOG: Zn-finger"]
["P0CJ79","Zinc finger protein 888 OS=Homo sapiens OX=9606 GN=ZNF888 PE=3 SV=2","ZNF888",0.564460493,0.125706599,"nochange",1317.47,596.371,1105.52,591.378,426.47,686.462,1.673448468,0.757509573,1.404229888,0.751167471,0.541701571,0.871943029,"nucleus","K09228","KRAB; KRAB domain-containing zinc finger protein","hsa05168 Herpes simplex virus 1 infection",{"$nulls":3},"PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger"]
["P0CJ92","Golgin subfamily A member 8H OS=Homo sapiens OX=9606 GN=GOLGA8H PE=3 SV=1","GOLGA8H",0.900146982,0.403780075,"nochange",4126.76,3797.97,3566.46,3250.37,4255.46,2837.93,1.133987483,1.043639669,0.980023311,0.893165315,1.169352804,0.779831417,"nucleus",{"$nulls":3},"GO:0000003 reproduction; GO:0000212 meiotic spindle organization; GO:0000226 microtubule cytoskeleton organization; GO:0000278 mitotic cell cycle; GO:0000280 nuclear division; GO:0006464 cellular protein modification process; GO:0006486 protein glycosylation; GO:0006807 nitrogen compound metabolic process; GO:0006810 transport; GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport; GO:0006900 vesicle budding from membrane; GO:0006901 vesicle coating; GO:0006903 vesicle targeting; GO:0006996 organelle organization; GO:0007010 cytoskeleton organization; GO:0007017 microtubule-based process; GO:0007020 microtubule nucleation; GO:0007030 Golgi organization; GO:0007049 cell cycle; GO:0007051 spindle organization; GO:0007052 mitotic spindle organization; GO:0007098 centrosome cycle; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008356 asymmetric cell division; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009100 glycoprotein metabolic process; GO:0009101 glycoprotein biosynthetic process; GO:0009889 regulation of biosynthetic process; GO:0009891 positive regulation of biosynthetic process; GO:0009892 negative regulation of metabolic process; GO:0009893 positive regulation of metabolic process; GO:0009894 regulation of catabolic process; GO:0009895 negative regulation of catabolic process; GO:0009987 cellular process; GO:0010256 endomembrane system organization; GO:0010506 regulation of autophagy; GO:0010507 negative regulation of autophagy; GO:0010556 regulation of macromolecule biosynthetic process; GO:0010557 positive regulation of macromolecule biosynthetic process; GO:0010559 regulation of glycoprotein biosynthetic process; GO:0010560 positive regulation of glycoprotein biosynthetic process; GO:0010604 positive regulation of macromolecule metabolic process; GO:0010720 positive regulation of cell development; GO:0010769 regulation of cell morphogenesis involved in differentiation; GO:0010770 positive regulation of cell morphogenesis involved in differentiation; GO:0010975 regulation of neuron projection development; GO:0010976 positive regulation of neuron projection development; GO:0016043 cellular component organization; GO:0016050 vesicle organization; GO:0016192 vesicle-mediated transport; GO:0019222 regulation of metabolic process; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0022402 cell cycle process; GO:0022411 cellular component disassembly; GO:0022414 reproductive process; GO:0022603 regulation of anatomical structure morphogenesis; GO:0022604 regulation of cell morphogenesis; GO:0022607 cellular component assembly; GO:0030154 cell differentiation; GO:0031023 microtubule organizing center organization; GO:0031109 microtubule polymerization or depolymerization; GO:0031323 regulation of cellular metabolic process; GO:0031324 negative regulation of cellular metabolic process; GO:0031325 positive regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0031328 positive regulation of cellular biosynthetic process; GO:0031329 regulation of cellular catabolic process; GO:0031330 negative regulation of cellular catabolic process; GO:0031344 regulation of cell projection organization; GO:0031346 positive regulation of cell projection organization; GO:0031396 regulation of protein ubiquitination; GO:0031398 positive regulation of protein ubiquitination; GO:0031399 regulation of protein modification process; GO:0031401 positive regulation of protein modification process; GO:0032091 negative regulation of protein binding; GO:0032268 regulation of cellular protein metabolic process; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034645 cellular macromolecule biosynthetic process; GO:0036211 protein modification process; GO:0043085 positive regulation of catalytic activity; GO:0043170 macromolecule metabolic process; GO:0043393 regulation of protein binding; GO:0043412 macromolecule modification; GO:0043413 macromolecule glycosylation; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045664 regulation of neuron differentiation; GO:0045666 positive regulation of neuron differentiation; GO:0046785 microtubule polymerization; GO:0046907 intracellular transport; GO:0048193 Golgi vesicle transport; GO:0048194 Golgi vesicle budding; GO:0048199 vesicle targeting"," to"," from or within Golgi; GO:0048207 vesicle targeting"," rough ER to cis-Golgi; GO:0048208 COPII vesicle coating; GO:0048285 organelle fission; GO:0048308 organelle inheritance; GO:0048313 Golgi inheritance; GO:0048518 positive regulation of biological process; GO:0048519 negative regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048523 negative regulation of cellular process; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048814 regulation of dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process; GO:0050767 regulation of neurogenesis; GO:0050769 positive regulation of neurogenesis; GO:0050773 regulation of dendrite development; GO:0050775 positive regulation of dendrite morphogenesis; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0051098 regulation of binding; GO:0051100 negative regulation of binding; GO:0051128 regulation of cellular component organization; GO:0051130 positive regulation of cellular component organization; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051173 positive regulation of nitrogen compound metabolic process; GO:0051179 localization; GO:0051225 spindle assembly; GO:0051234 establishment of localization; GO:0051239 regulation of multicellular organismal process; GO:0051240 positive regulation of multicellular organismal process; GO:0051246 regulation of protein metabolic process; GO:0051247 positive regulation of protein metabolic process; GO:0051258 protein polymerization; GO:0051259 protein complex oligomerization; GO:0051260 protein homooligomerization; GO:0051262 protein tetramerization; GO:0051289 protein homotetramerization; GO:0051301 cell division; GO:0051321 meiotic cell cycle; GO:0051338 regulation of transferase activity; GO:0051347 positive regulation of transferase activity; GO:0051438 regulation of ubiquitin-protein transferase activity; GO:0051443 positive regulation of ubiquitin-protein transferase activity; GO:0051640 organelle localization; GO:0051641 cellular localization; GO:0051648 vesicle localization; GO:0051649 establishment of localization in cell; GO:0051650 establishment of vesicle localization; GO:0051656 establishment of organelle localization; GO:0051960 regulation of nervous system development; GO:0051962 positive regulation of nervous system development; GO:0060049 regulation of protein glycosylation; GO:0060050 positive regulation of protein glycosylation; GO:0060255 regulation of macromolecule metabolic process; GO:0060284 regulation of cell development; GO:0061024 membrane organization; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0070085 glycosylation; GO:0070925 organelle assembly; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process; GO:0090114 COPII-coated vesicle budding; GO:0090161 Golgi ribbon formation; GO:0090166 Golgi disassembly; GO:0090306 meiotic spindle assembly; GO:0090307 mitotic spindle assembly; GO:0097435 supramolecular fiber organization; GO:0120035 regulation of plasma membrane bounded cell projection organization; GO:0140013 meiotic nuclear division; GO:0140014 mitotic nuclear division; GO:1900006 positive regulation of dendrite development; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1902850 microtubule cytoskeleton organization involved in mitosis; GO:1903008 organelle disassembly; GO:1903018 regulation of glycoprotein metabolic process; GO:1903020 positive regulation of glycoprotein metabolic process; GO:1903046 meiotic cell cycle process; GO:1903047 mitotic cell cycle process; GO:1903320 regulation of protein modification by small protein conjugation or removal; GO:1903322 positive regulation of protein modification by small protein conjugation or removal; GO:1904666 regulation of ubiquitin protein ligase activity; GO:1904668 positive regulation of ubiquitin protein ligase activity; GO:2000026 regulation of multicellular organismal development; GO:2000112 regulation of cellular macromolecule biosynthetic process;","GO:0000137 Golgi cis cisterna; GO:0000139 Golgi membrane; GO:0000922 spindle pole; GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0005793 endoplasmic reticulum-Golgi intermediate compartment; GO:0005794 Golgi apparatus; GO:0005795 Golgi stack; GO:0005798 Golgi-associated vesicle; GO:0005801 cis-Golgi network; GO:0005819 spindle; GO:0005829 cytosol; GO:0005856 cytoskeleton; GO:0012505 endomembrane system; GO:0015630 microtubule cytoskeleton; GO:0016020 membrane; GO:0030134 COPII-coated ER to Golgi transport vesicle; GO:0030135 coated vesicle; GO:0031090 organelle membrane; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0031984 organelle subcompartment; GO:0031985 Golgi cisterna; GO:0032580 Golgi cisterna membrane; GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0072686 mitotic spindle; GO:0097708 intracellular vesicle; GO:0098588 bounding membrane of organelle; GO:0098791 Golgi apparatus subcompartment;","GO:0000149 SNARE binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008017 microtubule binding; GO:0008092 cytoskeletal protein binding; GO:0015631 tubulin binding; GO:0019899 enzyme binding; GO:0019900 kinase binding; GO:0019901 protein kinase binding; GO:0019905 syntaxin binding; GO:0031267 small GTPase binding; GO:0042802 identical protein binding; GO:0051020 GTPase binding; GO:0061676 importin-alpha family protein binding;",null,null,"S","KOG4725","Uncharacterized conserved protein","WP4942 15Q133 COPY NUMBER VARIATION SYNDROME","http://www.wikipathways.org/instance/WP4942_r115789"]
["P0CK96","Solute carrier family 35 member E2B OS=Homo sapiens OX=9606 GN=SLC35E2B PE=2 SV=1","SLC35E2B",1.026614698,0.750212441,"nochange",3910.46,3351.42,4314.43,4115.48,4161.11,3607.82,1.000086954,0.85711436,1.103400919,1.052520127,1.064189846,0.922687795,"plasma membrane","K15284",{"$nulls":7},"GE","KOG1441","Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter"]
["P0DJ93","Small integral membrane protein 13 OS=Homo sapiens OX=9606 GN=SMIM13 PE=3 SV=1","SMIM13",1.057660924,0.939391342,"nochange",1451.25,1269.95,1978.69,1304.95,2452.45,1213.49,0.900392729,0.787909558,1.227630036,0.809624456,1.521562894,0.752880326,"extracellular"]
["Q3BBV2","Putative neuroblastoma breakpoint family member 8 OS=Homo sapiens OX=9606 GN=NBPF8 PE=5 SV=1","NBPF8",2.327313647,0.010284498,"nochange",1740.22,1811.46,"NA",4252.35,4833.87,3312.59,0.545506752,0.567838355,"NA",1.332984128,1.515273199,1.038397566,"nucleus",{"$nulls":6},"PF06758","PF06758 Olduvai domain"]
["Q3KRA6","UPF0538 protein C2orf76 OS=Homo sapiens OX=9606 GN=C2orf76 PE=1 SV=3","C2orf76",0.814251932,0.227899567,"nochange",7098.07,5630.2,5721.72,3786.78,5433.63,5802.53,1.272324233,1.009209531,1.025614429,0.678777747,0.973974492,1.040099567,"cytoplasm",{"$nulls":8},"S","KOG4147","Uncharacterized conserved protein"]
["Q4VC31","Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1","MIX23",1.210227941,0.11901432,"nochange",11322,11225.1,14001.8,13077.4,14796.8,16358.3,0.840936156,0.833738955,1.039977024,0.971317655,1.099025271,1.215004939,"extracellular",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"RD","KOG4613","Predicted component of DNA replication checkpoint response mechanism (S-M checkpoint)",{"$nulls":5},"FATTY ACID METABOLISM","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_FATTY_ACID_METABOLISM"]
["Q587I9","Vesicle transport protein SFT2C OS=Homo sapiens OX=9606 GN=SFT2D3 PE=2 SV=1","SFT2D3",1.745150343,0.000374764,"up",4922.32,4879.49,5208.53,8454.59,8209.69,9531.02,0.716744601,0.710508076,0.758419964,1.231082444,1.195422277,1.387822638,"plasma membrane",{"$nulls":3},"GO:0006810 transport; GO:0016192 vesicle-mediated transport; GO:0051179 localization; GO:0051234 establishment of localization;","GO:0016020 membrane;"]
["Q5JSJ4","Integrator complex subunit 6-like OS=Homo sapiens OX=9606 GN=INTS6L PE=1 SV=1","INTS6L",0.807370063,0.278392432,"nochange",2566.67,2104.52,2503.24,2232.52,1301.22,2258.68,1.187645419,0.973800113,1.158295191,1.033028068,0.602098428,1.045132781,"nucleus","K13180",null,null,"GO:0006139 nucleobase-containing compound metabolic process; GO:0006351 transcription"," DNA-templated; GO:0006366 transcription by RNA polymerase II; GO:0006396 RNA processing; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009301 snRNA transcription; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0016073 snRNA metabolic process; GO:0016180 snRNA processing; GO:0018130 heterocycle biosynthetic process; GO:0019438 aromatic compound biosynthetic process; GO:0023052 signaling; GO:0031123 RNA 3'-end processing; GO:0032774 RNA biosynthetic process; GO:0034470 ncRNA processing; GO:0034472 snRNA 3'-end processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034660 ncRNA metabolic process; GO:0042795 snRNA transcription by RNA polymerase II; GO:0043170 macromolecule metabolic process; GO:0043628 ncRNA 3'-end processing; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:0097659 nucleic acid-templated transcription; GO:0098781 ncRNA transcription; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0000428 DNA-directed RNA polymerase complex; GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005856 cytoskeleton; GO:0015629 actin cytoskeleton; GO:0016591 RNA polymerase II"," holoenzyme; GO:0030880 RNA polymerase complex; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0032039 integrator complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0043233 organelle lumen; GO:0055029 nuclear DNA-directed RNA polymerase complex; GO:0061695 transferase complex"," transferring phosphorus-containing groups; GO:0070013 intracellular organelle lumen; GO:1902494 catalytic complex; GO:1990234 transferase complex;","GO:0004888 transmembrane signaling receptor activity; GO:0038023 signaling receptor activity; GO:0060089 molecular transducer activity;","PF13519","PF13519 von Willebrand factor type A domain","R","KOG3768","DEAD box RNA helicase"]
["Q5R3I4","Tetratricopeptide repeat protein 38 OS=Homo sapiens OX=9606 GN=TTC38 PE=1 SV=1","TTC38",0.868501054,0.103376087,"nochange",9068.99,9540.62,9176.24,8897,8171.18,7063.86,1.048076877,1.102581788,1.060471448,1.028200491,0.944319578,0.816349817,"cytoplasm","K24942",{"$nulls":7},"S","KOG2610","Uncharacterized conserved protein"]
["Q5SVZ6","Zinc finger MYM-type protein 1 OS=Homo sapiens OX=9606 GN=ZMYM1 PE=1 SV=1","ZMYM1",0.570298022,0.000918856,"down",6349.49,7293.3,7493.58,4101.8,3728.21,4224.02,1.147830095,1.318447503,1.354653153,0.741503567,0.673967774,0.763597908,"nucleus","K24674",null,null,"GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003676 nucleic acid binding; GO:0003677 DNA binding; GO:0003700 DNA-binding transcription factor activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:0140110 transcription regulator activity; GO:1901363 heterocyclic compound binding;","PF06467; PF05699","PF06467 MYM-type Zinc finger with FCS sequence motif; PF05699 hAT family C-terminal dimerisation region"]
["Q5T6V5","Queuosine salvage protein OS=Homo sapiens OX=9606 GN=C9orf64 PE=1 SV=1","C9orf64",1.297389271,0.000267309,"up",21029.1,21494.4,20684.9,26923.2,28343.9,26738.8,0.868885502,0.888110882,0.854663762,1.112419369,1.1711202,1.104800285,"cytoplasm",{"$nulls":3},"GO:0006139 nucleobase-containing compound metabolic process; GO:0006396 RNA processing; GO:0006399 tRNA metabolic process; GO:0006400 tRNA modification; GO:0006725 cellular aromatic compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008033 tRNA processing; GO:0008152 metabolic process; GO:0009451 RNA modification; GO:0009987 cellular process; GO:0010467 gene expression; GO:0016070 RNA metabolic process; GO:0034470 ncRNA processing; GO:0034641 cellular nitrogen compound metabolic process; GO:0034660 ncRNA metabolic process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0046483 heterocycle metabolic process; GO:0071704 organic substance metabolic process; GO:0090304 nucleic acid metabolic process; GO:1901360 organic cyclic compound metabolic process;",{"$nulls":4},"H","KOG2524","Cobyrinic acid a","c-diamide synthase"]
["Q629K1","Triple QxxK/R motif-containing protein OS=Homo sapiens OX=9606 GN=TRIQK PE=3 SV=1","TRIQK",1.315209934,0.004146084,"up",3102.55,3194.51,3192.33,4308.4,4377.06,3795.08,0.847308116,0.872422443,0.871827084,1.176626416,1.1953775,1.036438441,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005783 endoplasmic reticulum; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;"]
["Q67FW5","UDP-GlcNAc:betaGal beta-1","3-N-acetylglucosaminyltransferase-like protein 1 OS=Homo sapiens OX=9606 GN=B3GNTL1 PE=2 SV=2","B3GNTL1",0.963517097,0.737645743,"nochange",3731.43,4159,3671.15,2562.43,4207.07,4370.28,0.986221971,1.099229297,0.970289886,0.677253698,1.111934263,1.155070886,"cytoplasm",{"$nulls":8},"R","KOG2977","Glycosyltransferase",{"$nulls":3},"R-HSA-392499 Metabolism of proteins;R-HSA-5173105 O-linked glycosylation;R-HSA-597592 Post-translational protein modification;R-HSA-913709 O-linked glycosylation of mucins","https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-5173105;https://reactome.org/PathwayBrowser/#/R-HSA-597592;https://reactome.org/PathwayBrowser/#/R-HSA-913709"]
["Q69YL0","Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1","NCBP2AS2",2.247974932,2.044569E-3,"up",8410.84,7476.43,10016.8,17105.4,22188.4,18937.9,0.599804815,0.533168948,0.714331134,1.219842642,1.582328182,1.350524278,"mitochondria"]
["Q69YW2","Protein stum homolog OS=Homo sapiens OX=9606 GN=STUM PE=1 SV=1","STUM",1.274263317,0.186676667,"nochange",1790.3,1027.17,1170.34,1788.62,1662.18,1630.72,1.184409433,0.679545237,0.774262266,1.183297994,1.099649037,1.078836033,"plasma membrane"]
["Q6DCA0","AMMECR1-like protein OS=Homo sapiens OX=9606 GN=AMMECR1L PE=1 SV=1","AMMECR1L",0.646828964,0.04776992,"nochange",1703.19,2403.48,1566.87,1357.64,1253.22,1058.95,1.093734046,1.543437846,1.00619371,0.871832908,0.80477773,0.68002376,"cytoplasm","K24611",{"$nulls":7},"S","KOG3274","Uncharacterized conserved protein"," AMMECR1"]
["Q6EEV4","DNA-directed RNA polymerase II subunit GRINL1A"," isoforms 4/5 OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1","POLR2M",1.509930133,0.034096257,"nochange",10820.7,8034.61,7550.68,15264.1,12110.6,12496.5,0.979585888,0.727364271,0.683554629,1.381841928,1.096359094,1.13129419,"nucleus"]
["Q6GMV3","Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1","PTRHD1",1.284427483,1.159525E-3,"up",48270.3,44038.4,45385.8,58994.8,60330.7,57533.1,0.920740568,0.840018426,0.865719651,1.125306983,1.150788849,1.097425522,"mitochondria","K05969",{"$nulls":7},"S","KOG3305","Uncharacterized conserved protein"]
["Q6P1X6","UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2","C8orf82",1.278433083,0.110397541,"nochange",5290.93,5593.3,5669.55,5571.09,7651.66,7940.15,0.841685429,0.889786694,0.901916606,0.886253509,1.21723227,1.263125492,"mitochondria",{"$nulls":3},"GO:0006950 response to stress; GO:0009611 response to wounding; GO:0042060 wound healing; GO:0050896 response to stimulus;"]
["Q6P3X3","Tetratricopeptide repeat protein 27 OS=Homo sapiens OX=9606 GN=TTC27 PE=1 SV=1","TTC27",0.855427614,0.014481717,"nochange",16316.6,17164.3,17132.5,14186.2,13717.3,15392.6,1.042488779,1.096649434,1.09461769,0.906374754,0.876416124,0.983453218,"cytoplasm","K24935",{"$nulls":7},"R","KOG1128","Uncharacterized conserved protein"," contains TPR repeats"]
["Q6ZRK6","Coiled-coil domain-containing protein 73 OS=Homo sapiens OX=9606 GN=CCDC73 PE=2 SV=2","CCDC73",1.013574725,0.941969055,"nochange",6973.15,6138.34,5920.94,5339.39,6771.14,7180.26,1.091737594,0.961037199,0.927000393,0.835951154,1.060110293,1.124163366,"nucleus"]
["Q6ZSJ8","Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=4 SV=2","C1orf122",1.011914024,0.948804359,"nochange",2545.5,1620.12,3045.21,2110.8,1913.87,3272.07,1.052760731,0.670044673,1.259429388,0.872978728,0.791532972,1.353253508,"extracellular"]
["Q6ZSR9","Uncharacterized protein FLJ45252 OS=Homo sapiens OX=9606 PE=2 SV=2","--",0.879714356,0.285886063,"nochange",7911.1,6096.21,7656.04,5843.28,6088.32,7125.96,1.165656661,0.898242696,1.128074987,0.860974865,0.897080149,1.049970642,"nucleus",{"$nulls":3},"GO:0000902 cell morphogenesis; GO:0000904 cell morphogenesis involved in differentiation; GO:0006464 cellular protein modification process; GO:0006468 protein phosphorylation; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0008152 metabolic process; GO:0008356 asymmetric cell division; GO:0008593 regulation of Notch signaling pathway; GO:0009653 anatomical structure morphogenesis; GO:0009966 regulation of signal transduction; GO:0009967 positive regulation of signal transduction; GO:0009987 cellular process; GO:0010646 regulation of cell communication; GO:0010647 positive regulation of cell communication; GO:0016043 cellular component organization; GO:0016310 phosphorylation; GO:0016358 dendrite development; GO:0019538 protein metabolic process; GO:0022008 neurogenesis; GO:0023051 regulation of signaling; GO:0023056 positive regulation of signaling; GO:0030030 cell projection organization; GO:0030100 regulation of endocytosis; GO:0030154 cell differentiation; GO:0030182 neuron differentiation; GO:0031175 neuron projection development; GO:0031647 regulation of protein stability; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032879 regulation of localization; GO:0032880 regulation of protein localization; GO:0032989 cellular component morphogenesis; GO:0032990 cell part morphogenesis; GO:0036211 protein modification process; GO:0043170 macromolecule metabolic process; GO:0043412 macromolecule modification; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0045747 positive regulation of Notch signaling pathway; GO:0046777 protein autophosphorylation; GO:0048259 regulation of receptor-mediated endocytosis; GO:0048468 cell development; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0048584 positive regulation of response to stimulus; GO:0048666 neuron development; GO:0048667 cell morphogenesis involved in neuron differentiation; GO:0048699 generation of neurons; GO:0048731 system development; GO:0048812 neuron projection morphogenesis; GO:0048813 dendrite morphogenesis; GO:0048856 anatomical structure development; GO:0048858 cell projection morphogenesis; GO:0048869 cellular developmental process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050821 protein stabilization; GO:0051049 regulation of transport; GO:0051128 regulation of cellular component organization; GO:0051301 cell division; GO:0060627 regulation of vesicle-mediated transport; GO:0061024 membrane organization; GO:0065007 biological regulation; GO:0065008 regulation of biological quality; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0120036 plasma membrane bounded cell projection organization; GO:0120039 plasma membrane bounded cell projection morphogenesis; GO:1901564 organonitrogen compound metabolic process; GO:2000369 regulation of clathrin-dependent endocytosis;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005886 plasma membrane; GO:0005905 clathrin-coated pit; GO:0012505 endomembrane system; GO:0016020 membrane; GO:0019897 extrinsic component of plasma membrane; GO:0019898 extrinsic component of membrane; GO:0030117 membrane coat; GO:0030118 clathrin coat; GO:0030135 coated vesicle; GO:0030136 clathrin-coated vesicle; GO:0030424 axon; GO:0030425 dendrite; GO:0031252 cell leading edge; GO:0031410 cytoplasmic vesicle; GO:0031982 vesicle; GO:0032991 protein-containing complex; GO:0036477 somatodendritic compartment; GO:0042995 cell projection; GO:0043005 neuron projection; GO:0043025 neuronal cell body; GO:0043195 terminal bouton; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043679 axon terminus; GO:0044297 cell body; GO:0044306 neuron projection terminus; GO:0045202 synapse; GO:0048475 coated membrane; GO:0071439 clathrin complex; GO:0071944 cell periphery; GO:0097447 dendritic tree; GO:0097708 intracellular vesicle; GO:0098793 presynapse; GO:0098796 membrane protein complex; GO:0120025 plasma membrane bounded cell projection; GO:0150034 distal axon;","GO:0003824 catalytic activity; GO:0004672 protein kinase activity; GO:0004674 protein serine/threonine kinase activity; GO:0005102 signaling receptor binding; GO:0005112 Notch binding; GO:0005488 binding; GO:0005515 protein binding; GO:0016301 kinase activity; GO:0016740 transferase activity; GO:0016772 transferase activity"," transferring phosphorus-containing groups; GO:0016773 phosphotransferase activity"," alcohol group as acceptor; GO:0019904 protein domain specific binding; GO:0035612 AP-2 adaptor complex binding; GO:0044877 protein-containing complex binding; GO:0051425 PTB domain binding; GO:0140096 catalytic activity"," acting on a protein;",null,null,"T","KOG1989","ARK protein kinase family"]
["Q6ZV70","LanC-like protein 3 OS=Homo sapiens OX=9606 GN=LANCL3 PE=2 SV=2","LANCL3",1.463080781,0.026841316,"nochange",10963,10782.2,10838.1,18133,16821.8,12717.2,0.819609421,0.806092557,0.81027172,1.355648786,1.257621615,0.9507559,"cytoplasm",{"$nulls":3},"GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009987 cellular process; GO:0023052 signaling; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation;","GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;",{"$nulls":3},"V","KOG2787","Lanthionine synthetase C-like protein 1"]
["Q7Z6I8","UPF0461 protein C5orf24 OS=Homo sapiens OX=9606 GN=C5orf24 PE=1 SV=1","C5orf24",1.480536377,0.096504543,"nochange",4071.89,2169.41,2928.37,4020.37,5098.53,4457.13,1.074108073,0.572260251,0.772463367,1.060517812,1.344921458,1.175729039,"nucleus"]
["Q86V85","Integral membrane protein GPR180 OS=Homo sapiens OX=9606 GN=GPR180 PE=2 SV=1","GPR180",0.761196457,0.198166467,"nochange",1468,1032.87,1736.81,949.307,1126.63,1149.77,1.180161232,0.830349545,1.396264189,0.763171198,0.90572551,0.924328324,"plasma membrane",{"$nulls":8},"S","KOG4290","Predicted membrane protein"]
["Q86VQ1","Glucocorticoid-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=GLCCI1 PE=1 SV=1","GLCCI1",0.850838277,0.748189509,"nochange",4423.94,2605.41,6945.75,2968.84,5322.38,3599.33,1.026211984,0.604371435,1.611190904,0.688675521,1.234621206,0.83492895,"nucleus",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;"]
["Q86X53","Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1","ERICH1",0.760387557,0.095029367,"nochange",4185.34,6057.14,4819.05,4235.58,3484.43,3732.59,0.94711914,1.370697059,1.090524185,0.958488172,0.788507109,0.844664336,"nucleus"]
["Q86XN7","Proline and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=PROSER1 PE=1 SV=2","PROSER1",0.811720646,0.173075444,"nochange",2738.14,3744.64,3586.46,3136.9,2601.88,2434.63,0.900573108,1.231610539,1.179585203,1.031725106,0.85575725,0.800748795,"nucleus"]
["Q8IVB5","LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=2 SV=1","LIX1L",0.850636626,0.380695507,"nochange",2386.26,2429.42,2272.47,2884.27,1438.57,1706.6,1.091477932,1.111219363,1.039430261,1.31926825,0.65800349,0.780600705,"nucleus","K16673",null,null,"GO:0002009 morphogenesis of an epithelium; GO:0002165 instar larval or pupal development; GO:0006914 autophagy; GO:0007275 multicellular organism development; GO:0007444 imaginal disc development; GO:0007472 wing disc morphogenesis; GO:0007476 imaginal disc-derived wing morphogenesis; GO:0007552 metamorphosis; GO:0007560 imaginal disc morphogenesis; GO:0008152 metabolic process; GO:0009056 catabolic process; GO:0009653 anatomical structure morphogenesis; GO:0009791 post-embryonic development; GO:0009886 post-embryonic animal morphogenesis; GO:0009887 animal organ morphogenesis; GO:0009888 tissue development; GO:0009987 cellular process; GO:0016043 cellular component organization; GO:0016236 macroautophagy; GO:0022411 cellular component disassembly; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0032984 protein-containing complex disassembly; GO:0035107 appendage morphogenesis; GO:0035114 imaginal disc-derived appendage morphogenesis; GO:0035120 post-embryonic appendage morphogenesis; GO:0035220 wing disc development; GO:0035239 tube morphogenesis; GO:0035295 tube development; GO:0043933 protein-containing complex organization; GO:0044237 cellular metabolic process; GO:0044248 cellular catabolic process; GO:0048513 animal organ development; GO:0048563 post-embryonic animal organ morphogenesis; GO:0048569 post-embryonic animal organ development; GO:0048707 instar larval or pupal morphogenesis; GO:0048729 tissue morphogenesis; GO:0048731 system development; GO:0048736 appendage development; GO:0048737 imaginal disc-derived appendage development; GO:0048856 anatomical structure development; GO:0060429 epithelium development; GO:0060562 epithelial tube morphogenesis; GO:0061919 process utilizing autophagic mechanism; GO:0071840 cellular component organization or biogenesis; GO:0097352 autophagosome maturation;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0005911 cell-cell junction; GO:0016020 membrane; GO:0030054 cell junction; GO:0032991 protein-containing complex; GO:0035003 subapical complex; GO:0043296 apical junction complex; GO:0071944 cell periphery; GO:0098796 membrane protein complex; GO:0098797 plasma membrane protein complex;"]
["Q8IYQ7","Threonine synthase-like 1 OS=Homo sapiens OX=9606 GN=THNSL1 PE=1 SV=2","THNSL1",1.47410793,0.004056559,"up",15678,14432.7,13997.4,20211.5,20680.2,24128.4,0.861995341,0.793527246,0.769593927,1.111252637,1.137022328,1.326608521,"cytoplasm","mitochondria",{"$nulls":6},"PF01202; PF14821","PF01202 Shikimate kinase; PF14821 Threonine synthase N terminus","E","KOG2616","Pyridoxalphosphate-dependent enzyme/predicted threonine synthase"]
["Q8IZQ5","Selenoprotein H OS=Homo sapiens OX=9606 GN=SELENOH PE=1 SV=2","SELENOH",0.916850531,0.150508263,"nochange",48876,47537.5,43589.8,44904.4,43485.7,39972,1.092748916,1.0628233,0.974562295,1.003953565,0.972234871,0.893677054,"nucleus",{"$nulls":11},"WP15 SELENIUM MICRONUTRIENT NETWORK","http://www.wikipathways.org/instance/WP15_r118387"]
["Q8N614","Transmembrane protein 156 OS=Homo sapiens OX=9606 GN=TMEM156 PE=2 SV=2","TMEM156",0.513495317,0.122097697,"nochange",3999.6,3550.23,2272.54,1870.13,2386.28,787.331,1.614248676,1.432881807,0.917202892,0.754789198,0.963108644,0.317768783,"plasma membrane"]
["Q8N8J7","Uncharacterized protein FAM241A OS=Homo sapiens OX=9606 GN=FAM241A PE=2 SV=2","FAM241A",0.66238635,0.032399265,"nochange",6403.27,8186.87,9368.37,5745.37,5395.75,4728.67,0.964631179,1.233324546,1.411313563,0.865520748,0.812851666,0.712358298,"plasma membrane",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0012505 endomembrane system; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;"]
["Q8N999","Uncharacterized protein C12orf29 OS=Homo sapiens OX=9606 GN=C12orf29 PE=1 SV=2","C12orf29",1.76121663,1.237277E-3,"up",3588.39,4432.04,3939.49,7286.99,7220.88,6556.14,0.651961774,0.805241532,0.715751881,1.32394721,1.31193592,1.191161682,"mitochondria",{"$nulls":3},"GO:0002244 hematopoietic progenitor cell differentiation; GO:0002376 immune system process; GO:0002520 immune system development; GO:0007275 multicellular organism development; GO:0009987 cellular process; GO:0030097 hemopoiesis; GO:0030154 cell differentiation; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0048513 animal organ development; GO:0048534 hematopoietic or lymphoid organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0048869 cellular developmental process;"]
["Q8N9Z2","Coiled-coil domain-containing protein 71L OS=Homo sapiens OX=9606 GN=CCDC71L PE=1 SV=2","CCDC71L",0.779476319,0.506558516,"nochange",1829.79,3761.28,1865,1986.36,2599.83,1225.64,0.827466291,1.700923281,0.843388931,0.898270261,1.175693214,0.554258021,"mitochondria",{"$nulls":3},"GO:0006629 lipid metabolic process; GO:0008152 metabolic process; GO:0009987 cellular process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044255 cellular lipid metabolic process; GO:0045595 regulation of cell differentiation; GO:0045597 positive regulation of cell differentiation; GO:0045598 regulation of fat cell differentiation; GO:0045600 positive regulation of fat cell differentiation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0050789 regulation of biological process; GO:0050793 regulation of developmental process; GO:0050794 regulation of cellular process; GO:0051094 positive regulation of developmental process; GO:0065007 biological regulation; GO:0071704 organic substance metabolic process;"]
["Q8NBP0","Tetratricopeptide repeat protein 13 OS=Homo sapiens OX=9606 GN=TTC13 PE=2 SV=3","TTC13",1.423256844,4.795E-4,"up",4735.4,4490.42,4325.03,6165.31,6622.23,6498.8,0.86525065,0.820487989,0.790267986,1.126523311,1.210011575,1.187458488,"extracellular",{"$nulls":8},"GOT","KOG4626","O-linked N-acetylglucosamine transferase OGT"]
["Q8NCJ5","SPRY domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SPRYD3 PE=1 SV=2","SPRYD3",0.595067072,2.476186E-3,"down",7605.61,7314.42,7787.78,4745.53,3858.96,4908.18,1.259885568,1.211649321,1.290062418,0.786107197,0.63924498,0.813050517,"mitochondria",{"$nulls":8},"R","KOG1477","SPRY domain-containing proteins"]
["Q8NCS4","Transmembrane protein 35B OS=Homo sapiens OX=9606 GN=TMEM35B PE=1 SV=1","TMEM35B",0.955082002,0.760554855,"nochange",4668.57,5694.3,6594.03,4905.38,6632.57,4657.28,0.844935755,1.030576316,1.193412912,0.88779454,1.200388029,0.842892448,"plasma membrane"]
["Q8ND24","RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2","RNF214",0.69310003,2.1676E-4,"down",16689.9,16950.5,16697.5,10990.9,11843.5,12054.8,1.174971341,1.193317618,1.175506382,0.773760928,0.83378409,0.84865964,"cytoplasm"]
["Q8TAC1","Rieske domain-containing protein OS=Homo sapiens OX=9606 GN=RFESD PE=1 SV=1","RFESD",1.81088408,0.027135189,"nochange",2298.74,3595.86,2002.99,4326.62,4894,5081,0.621303191,0.971888639,0.541367914,1.16939837,1.322749774,1.373292113,"cytoplasm",{"$nulls":6},"PF00355","PF00355 Rieske [2Fe-2S] domain"]
["Q8TCA0","Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1","LRRC20",0.951986762,0.747044247,"nochange",2254.79,2808.94,2037.02,2527.24,1546.08,2686.5,0.976059426,1.215941336,0.881790576,1.093998299,0.669271177,1.162939186,"cytoplasm",{"$nulls":3},"GO:0003008 system process; GO:0003012 muscle system process; GO:0032501 multicellular organismal process;",{"$nulls":4},"R","KOG4579","Leucine-rich repeat (LRR) protein associated with apoptosis in muscle tissue"]
["Q8TD47","40S ribosomal protein S4"," Y isoform 2 OS=Homo sapiens OX=9606 GN=RPS4Y2 PE=2 SV=3","RPS4Y2",0.819161717,0.524004783,"nochange",6871.7,3387.18,4615.57,5110.95,4189.16,2884.47,1.523713156,0.751064617,1.023444669,1.133288961,0.928893608,0.639594989,"cytoplasm","K02987","RP-S4e; small subunit ribosomal protein S4e","hsa03010 Ribosome; hsa05171 Coronavirus disease - COVID-19","GO:0006412 translation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007275 multicellular organism development; GO:0007399 nervous system development; GO:0007417 central nervous system development; GO:0007420 brain development; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009790 embryo development; GO:0009792 embryo development ending in birth or egg hatching; GO:0009987 cellular process; GO:0010467 gene expression; GO:0019538 protein metabolic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0043009 chordate embryonic development; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0060322 head development; GO:0071704 organic substance metabolic process; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005840 ribosome; GO:0015935 small ribosomal subunit; GO:0022626 cytosolic ribosome; GO:0022627 cytosolic small ribosomal subunit; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044391 ribosomal subunit; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;","PF08071","PF08071 RS4NT (NUC023) domain","J","KOG0378","40S ribosomal protein S4",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-156842 Eukaryotic Translation Elongation;R-HSA-156902 Peptide chain elongation;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-192823 Viral mRNA Translation;R-HSA-2262752 Cellular responses to stress;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-2408557 Selenocysteine synthesis;R-HSA-376176 Signaling by ROBO receptors;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-5663205 Infectious disease;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-72312 rRNA processing;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72649 Translation initiation complex formation;R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs"," and subsequent binding to 43S;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72695 Formation of the ternary complex"," and subsequently"," the 43S complex;R-HSA-72702 Ribosomal scanning and start codon recognition;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72764 Eukaryotic Translation Termination;R-HSA-72766 Translation;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-927802 Nonsense-Mediated Decay (NMD);R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency;R-HSA-9675108 Nervous system development;R-HSA-9679506 SARS-CoV Infections;R-HSA-9694516 SARS-CoV-2 Infection;R-HSA-9705683 SARS-CoV-2-host interactions;R-HSA-9711097 Cellular response to starvation;R-HSA-9754678 SARS-CoV-2 modulates host translation machinery;R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["Q8WUD4","Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1","CCDC12",1.044666137,0.652119868,"nochange",10352,8996.3,11089.3,9561.03,10329.8,11906.3,0.99802795,0.867326009,1.069110447,0.921771172,0.995887666,1.147876756,"nucleus","K12871","CCDC12; coiled-coil domain-containing protein 12","hsa03040 Spliceosome",{"$nulls":5},"S","KOG3407","Uncharacterized conserved protein"]
["Q8WUR7","UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2","C15orf40",0.463619802,0.000722596,"down",2814.59,3020.88,3501.34,1302.11,1533.09,1493.53,1.235775535,1.326349343,1.537300392,0.57170518,0.673119394,0.655750157,"mitochondria","K09131",{"$nulls":5},"PF02594","PF02594 Uncharacterised ACR"," YggU family COG1872","S","KOG3276","Uncharacterized conserved protein"," contains YggU domain"]
["Q8WUY1","Protein THEM6 OS=Homo sapiens OX=9606 GN=THEM6 PE=1 SV=2","THEM6",1.341141403,0.002786763,"up",11398.6,11519.8,10764.7,16262.3,14465.9,14445.6,0.867287454,0.876509221,0.819055783,1.237352724,1.100669694,1.099125124,"extracellular",{"$nulls":8},"R","KOG4366","Predicted thioesterase"]
["Q8WW59","SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=2","SPRYD4",1.146920721,0.108795512,"nochange",12787.1,15261.9,14225.5,15492.5,15415.4,17577.6,0.845334949,1.008940062,0.940425297,1.024184663,1.019087704,1.162027325,"mitochondria",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"O","KOG2177","Predicted E3 ubiquitin ligase"]
["Q8WZA9","Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1","IRGQ",1.579695033,1.76195E-4,"up",20182.6,19226.3,19954.9,32484.6,29404.9,31887.2,0.790748365,0.753280811,0.781827146,1.272737127,1.152075382,1.24933117,"cytoplasm","nucleus"]
["Q92623","Tetratricopeptide repeat protein 9A OS=Homo sapiens OX=9606 GN=TTC9 PE=1 SV=3","TTC9",1.224401292,0.028532515,"nochange",1602.38,1488.53,1726.13,1860.66,2135.17,1902.16,0.89727047,0.833518898,0.966565656,1.041897223,1.195612145,1.065135609,"extracellular","K24930",null,null,"GO:0001501 skeletal system development; GO:0007275 multicellular organism development; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0048513 animal organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0060348 bone development;",{"$nulls":7},"WP2817 MAMMARY GLAND DEVELOPMENT PATHWAY PREGNANCY AND LACTATION STAGE 3 OF 4","http://www.wikipathways.org/instance/WP2817_r102410"]
["Q96AT1","Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2","KIAA1143",1.741373375,0.008717673,"up",5210.29,5720.28,5105.25,10452.5,7421.65,10050.2,0.711137832,0.780744933,0.696801218,1.426632336,1.012960141,1.37172354,"nucleus"]
["Q96B54","Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2","ZNF428",1.891758291,0.006512236,"up",6779.02,5947.69,4549.44,10262.7,11811.4,10608.2,0.814158966,0.714316397,0.546386847,1.232548248,1.418546812,1.27404273,"nucleus"]
["Q96B70","Leukocyte receptor cluster member 9 OS=Homo sapiens OX=9606 GN=LENG9 PE=2 SV=2","LENG9",0.662736284,0.063924263,"nochange",3806.55,4545.63,4552.84,3325.65,"NA",2376.1,1.022893818,1.221498949,1.223436416,0.89366666,"NA",0.638504157,"mitochondria",{"$nulls":6},"PF04457; PF10469","PF04457 MJ1316 RNA cyclic group end recognition domain; PF10469 AKAP7 2'5' RNA ligase-like domain"]
["Q96CN7","Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3","ISOC1",1.436402952,0.000182474,"up",73332.5,70398.2,75055.4,101449,104266,108550,0.825427431,0.792399078,0.844820318,1.141905532,1.173613562,1.221834079,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005777 peroxisome; GO:0042579 microbody; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",{"$nulls":3},"R","KOG4044","Mitochondrial associated endoribonuclease MAR1 (isochorismatase superfamily)",{"$nulls":5},"BILE ACID METABOLISM;INTERFERON GAMMA RESPONSE;PEROXISOME","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_BILE_ACID_METABOLISM;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_INTERFERON_GAMMA_RESPONSE;https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PEROXISOME"]
["Q96CP2","FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1","FLYWCH2",0.667503612,0.004934175,"down",2910.14,2536.31,2734.09,1616.4,1982.97,1861.17,1.280018884,1.115590554,1.202583666,0.710970099,0.872205133,0.818631663,"nucleus"]
["Q96D70","R3H domain-containing protein 4 OS=Homo sapiens OX=9606 GN=R3HDM4 PE=1 SV=3","R3HDM4",0.683134472,0.132772591,"nochange",4816.66,4166.1,4316.32,2013.07,2722.2,4349.79,1.291090924,1.116710314,1.156976323,0.539597233,0.729677352,1.165947854,"nucleus",{"$nulls":6},"PF13902; PF01424","PF13902 R3H-associated N-terminal domain; PF01424 R3H domain","I","KOG1478","3-keto sterol reductase"]
["Q96EK9","Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1","KTI12",1.142605304,0.082729807,"nochange",12459.5,12492.7,14528.8,15504.8,15439.1,14167.3,0.883733961,0.886088788,1.030506359,1.099732599,1.095072595,1.004865697,"extracellular","K15456",{"$nulls":5},"PF08433","PF08433 Chromatin associated protein KTI12 ","R","KOG3062","RNA polymerase II elongator associated protein"]
["Q96EX1","Small integral membrane protein 12 OS=Homo sapiens OX=9606 GN=SMIM12 PE=1 SV=3","SMIM12",1.177597021,2.422422E-3,"up",8898.17,8899.81,9189.86,10145.5,10801.2,10834.1,0.908461043,0.908628479,0.938241212,1.035807533,1.102751399,1.106110334,"extracellular"]
["Q96F63","Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1","CCDC97",0.391784071,0.000333789,"down",18615.8,17609.4,20026.5,6500.73,7172.24,8365.55,1.426676282,1.349547875,1.534789403,0.498202457,0.54966559,0.641118393,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005686 U2 snRNP; GO:0030532 small nuclear ribonucleoprotein complex; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0097525 spliceosomal snRNP complex; GO:0120114 Sm-like protein family complex; GO:1990904 ribonucleoprotein complex;",{"$nulls":3},"S","KOG3044","Uncharacterized conserved protein"]
["Q96FK6","WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=2 SV=1","WDR89",0.750262001,0.010246096,"nochange",6409.32,6737.82,6700.1,4874.06,4479.26,5537.31,1.107031606,1.163770836,1.157255756,0.84185818,0.77366747,0.956416153,"nucleus","K24758",{"$nulls":7},"R","KOG1188","WD40 repeat protein"]
["Q96H35","Probable RNA-binding protein 18 OS=Homo sapiens OX=9606 GN=RBM18 PE=2 SV=1","RBM18",1.721771819,3.357109E-3,"up",3138.24,2860.21,3458.5,5149.64,4962.9,6170.17,0.731534138,0.666724424,0.806187805,1.20039814,1.156868428,1.438287064,"nucleus","K24527",{"$nulls":5},"PF00076","PF00076 RNA recognition motif. (a.k.a. RRM"," RBD"," or RNP domain)"]
["Q96IR2","Zinc finger protein 845 OS=Homo sapiens OX=9606 GN=ZNF845 PE=1 SV=3","ZNF845",1.820286489,0.10322933,"nochange",367.668,949.675,717.223,946.223,1265.53,1491.74,0.384451955,0.993027433,0.749964056,0.98941785,1.323301137,1.559837569,"nucleus","K09228","KRAB; KRAB domain-containing zinc finger protein","hsa05168 Herpes simplex virus 1 infection","GO:0002376 immune system process; GO:0002520 immune system development; GO:0006355 regulation of transcription"," DNA-templated; GO:0006357 regulation of transcription by RNA polymerase II; GO:0007275 multicellular organism development; GO:0009889 regulation of biosynthetic process; GO:0010468 regulation of gene expression; GO:0010556 regulation of macromolecule biosynthetic process; GO:0019219 regulation of nucleobase-containing compound metabolic process; GO:0019222 regulation of metabolic process; GO:0030097 hemopoiesis; GO:0031323 regulation of cellular metabolic process; GO:0031326 regulation of cellular biosynthetic process; GO:0032501 multicellular organismal process; GO:0032502 developmental process; GO:0048513 animal organ development; GO:0048534 hematopoietic or lymphoid organ development; GO:0048731 system development; GO:0048856 anatomical structure development; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0051171 regulation of nitrogen compound metabolic process; GO:0051252 regulation of RNA metabolic process; GO:0060255 regulation of macromolecule metabolic process; GO:0065007 biological regulation; GO:0080090 regulation of primary metabolic process; GO:1903506 regulation of nucleic acid-templated transcription; GO:2000112 regulation of cellular macromolecule biosynthetic process; GO:2001141 regulation of RNA biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0031974 membrane-enclosed lumen; GO:0031981 nuclear lumen; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;","GO:0000981 DNA-binding transcription factor activity"," RNA polymerase II-specific; GO:0003700 DNA-binding transcription factor activity; GO:0140110 transcription regulator activity;","PF00096","PF00096 Zinc finger"," C2H2 type","R","KOG1721","FOG: Zn-finger"]
["Q96KF7","Small integral membrane protein 8 OS=Homo sapiens OX=9606 GN=SMIM8 PE=1 SV=2","SMIM8",0.891950185,0.065798504,"nochange",5195.9,5125.24,4561.81,4307.22,4392.72,4574.91,1.107167463,1.092110889,0.972052504,0.917803237,0.93602199,0.974843915,"cytoplasm"]
["Q96MH6","Transmembrane protein 68 OS=Homo sapiens OX=9606 GN=TMEM68 PE=2 SV=2","TMEM68",1.347816204,1.426566E-3,"up",4867.37,4690.35,4916.62,6402.71,6163.32,6942.72,0.85937506,0.828120692,0.868070561,1.130452234,1.088185918,1.225795535,"endoplasmic reticulum",{"$nulls":4},"GO:0016020 membrane;",{"$nulls":3},"I","KOG4321","Predicted phosphate acyltransferases"]
["Q96MP5","Zinc finger SWIM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZSWIM3 PE=1 SV=2","ZSWIM3",1.350253408,0.391242354,"nochange",3004.95,"NA",1741.68,2321.72,3016.2,4275.81,1.046265553,"NA",0.606419338,0.808378063,1.050182586,1.48875446,"nucleus","K17604",{"$nulls":5},"PF04434; PF19286","PF04434 SWIM zinc finger; PF19286 Domain of unknown function (DUF5909)"]
["Q9BPW8","Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1","NIPSNAP1",1.260459271,0.031771852,"nochange",36694.2,33531.3,31949.4,43883.6,46619.2,38284.5,0.953252091,0.871085398,0.829990362,1.140020315,1.211086489,0.994565344,"mitochondria",{"$nulls":3},"GO:0003008 system process; GO:0006091 generation of precursor metabolites and energy; GO:0006119 oxidative phosphorylation; GO:0006139 nucleobase-containing compound metabolic process; GO:0006163 purine nucleotide metabolic process; GO:0006164 purine nucleotide biosynthetic process; GO:0006725 cellular aromatic compound metabolic process; GO:0006753 nucleoside phosphate metabolic process; GO:0006754 ATP biosynthetic process; GO:0006793 phosphorus metabolic process; GO:0006796 phosphate-containing compound metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0007600 sensory perception; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009117 nucleotide metabolic process; GO:0009123 nucleoside monophosphate metabolic process; GO:0009124 nucleoside monophosphate biosynthetic process; GO:0009126 purine nucleoside monophosphate metabolic process; GO:0009127 purine nucleoside monophosphate biosynthetic process; GO:0009141 nucleoside triphosphate metabolic process; GO:0009142 nucleoside triphosphate biosynthetic process; GO:0009144 purine nucleoside triphosphate metabolic process; GO:0009145 purine nucleoside triphosphate biosynthetic process; GO:0009150 purine ribonucleotide metabolic process; GO:0009152 purine ribonucleotide biosynthetic process; GO:0009156 ribonucleoside monophosphate biosynthetic process; GO:0009161 ribonucleoside monophosphate metabolic process; GO:0009165 nucleotide biosynthetic process; GO:0009167 purine ribonucleoside monophosphate metabolic process; GO:0009168 purine ribonucleoside monophosphate biosynthetic process; GO:0009199 ribonucleoside triphosphate metabolic process; GO:0009201 ribonucleoside triphosphate biosynthetic process; GO:0009205 purine ribonucleoside triphosphate metabolic process; GO:0009206 purine ribonucleoside triphosphate biosynthetic process; GO:0009259 ribonucleotide metabolic process; GO:0009260 ribonucleotide biosynthetic process; GO:0009987 cellular process; GO:0010959 regulation of metal ion transport; GO:0016310 phosphorylation; GO:0018130 heterocycle biosynthetic process; GO:0019233 sensory perception of pain; GO:0019438 aromatic compound biosynthetic process; GO:0019637 organophosphate metabolic process; GO:0019693 ribose phosphate metabolic process; GO:0022898 regulation of transmembrane transporter activity; GO:0032409 regulation of transporter activity; GO:0032411 positive regulation of transporter activity; GO:0032412 regulation of ion transmembrane transporter activity; GO:0032414 positive regulation of ion transmembrane transporter activity; GO:0032501 multicellular organismal process; GO:0032879 regulation of localization; GO:0034641 cellular nitrogen compound metabolic process; GO:0034654 nucleobase-containing compound biosynthetic process; GO:0034762 regulation of transmembrane transport; GO:0034764 positive regulation of transmembrane transport; GO:0034765 regulation of ion transmembrane transport; GO:0034767 positive regulation of ion transmembrane transport; GO:0043086 negative regulation of catalytic activity; GO:0043269 regulation of ion transport; GO:0043270 positive regulation of ion transport; GO:0044092 negative regulation of molecular function; GO:0044093 positive regulation of molecular function; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0044281 small molecule metabolic process; GO:0046034 ATP metabolic process; GO:0046390 ribose phosphate biosynthetic process; GO:0046483 heterocycle metabolic process; GO:0048518 positive regulation of biological process; GO:0050789 regulation of biological process; GO:0050790 regulation of catalytic activity; GO:0050877 nervous system process; GO:0051049 regulation of transport; GO:0051050 positive regulation of transport; GO:0051338 regulation of transferase activity; GO:0051348 negative regulation of transferase activity; GO:0051924 regulation of calcium ion transport; GO:0051928 positive regulation of calcium ion transport; GO:0055086 nucleobase-containing small molecule metabolic process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function; GO:0071704 organic substance metabolic process; GO:0072521 purine-containing compound metabolic process; GO:0072522 purine-containing compound biosynthetic process; GO:0090407 organophosphate biosynthetic process; GO:1901019 regulation of calcium ion transmembrane transporter activity; GO:1901021 positive regulation of calcium ion transmembrane transporter activity; GO:1901135 carbohydrate derivative metabolic process; GO:1901137 carbohydrate derivative biosynthetic process; GO:1901293 nucleoside phosphate biosynthetic process; GO:1901360 organic cyclic compound metabolic process; GO:1901362 organic cyclic compound biosynthetic process; GO:1901385 regulation of voltage-gated calcium channel activity; GO:1901387 positive regulation of voltage-gated calcium channel activity; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process; GO:1901841 regulation of high voltage-gated calcium channel activity; GO:1901843 positive regulation of high voltage-gated calcium channel activity; GO:1903169 regulation of calcium ion transmembrane transport; GO:1904062 regulation of cation transmembrane transport; GO:1904064 positive regulation of cation transmembrane transport; GO:1904427 positive regulation of calcium ion transmembrane transport; GO:2000983 regulation of ATP citrate synthase activity; GO:2000984 negative regulation of ATP citrate synthase activity; GO:2001257 regulation of cation channel activity; GO:2001259 positive regulation of cation channel activity;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005741 mitochondrial outer membrane; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0019867 outer membrane; GO:0031090 organelle membrane; GO:0031966 mitochondrial membrane; GO:0031967 organelle envelope; GO:0031968 organelle outer membrane; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0045202 synapse; GO:0071944 cell periphery; GO:0097060 synaptic membrane; GO:0098588 bounding membrane of organelle; GO:0098590 plasma membrane region;","GO:0005488 binding; GO:0042165 neurotransmitter binding;","PF07978","PF07978 NIPSNAP ","S","KOG2883","NIPSNAP1 protein"]
["Q9BPX7","UPF0415 protein C7orf25 OS=Homo sapiens OX=9606 GN=C7orf25 PE=1 SV=1","C7orf25",0.834385415,0.445406165,"nochange",2187.4,1640.24,2575.54,1295.47,1465.35,2581.9,1.1173601,0.837861722,1.315628432,0.661747503,0.748525017,1.318877225,"cytoplasm",{"$nulls":6},"PF18474; PF07000","PF18474 Family of unknown function (DUF5614); PF07000 Protein of unknown function (DUF1308)","S","KOG4529","Uncharacterized conserved protein"]
["Q9BQ49","Small integral membrane protein 7 OS=Homo sapiens OX=9606 GN=SMIM7 PE=1 SV=2","SMIM7",1.03449918,0.794586417,"nochange",2400.37,1236.98,2725.41,2432.39,2437.85,1712.03,1.112567526,0.573338185,1.263223028,1.127408743,1.129939444,0.793523074,"extracellular"]
["Q9BRJ6","Uncharacterized protein C7orf50 OS=Homo sapiens OX=9606 GN=C7orf50 PE=1 SV=1","C7orf50",0.798435419,0.004886937,"down",24380.6,24906.8,24444.8,20761.6,19947.9,18160.9,1.103172939,1.126982427,1.10607786,0.939420494,0.902602211,0.821744068,"nucleus",{"$nulls":6},"PF10180","PF10180 WKF domain","S","KOG4829","Uncharacterized conserved protein"]
["Q9BRP1","Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1","PDCD2L",0.777335629,0.026200115,"nochange",23719.8,26406.4,21066.6,17492.7,19466,18382,1.124751943,1.252145874,0.998941782,0.829473618,0.923044095,0.871642688,"extracellular","K14801",{"$nulls":5},"PF04194","PF04194 Programmed cell death protein 2"," C-terminal putative domain ","R","KOG2061","Uncharacterized MYND Zn-finger protein",{"$nulls":5},"IL2 STAT5 SIGNALING","https://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_IL2_STAT5_SIGNALING"]
["Q9BS92","Protein NipSnap homolog 3B OS=Homo sapiens OX=9606 GN=NIPSNAP3B PE=2 SV=1","NIPSNAP3B",1.859768772,0.02316882,"nochange",2269.32,"NA",2009.28,4782.56,3806.97,3346.28,0.699784944,"NA",0.619597013,1.474786933,1.173946508,1.031884601,"mitochondria",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle;",null,"PF07978","PF07978 NIPSNAP ","S","KOG2883","NIPSNAP1 protein"]
["Q9BTX7","Alpha-tocopherol transfer protein-like OS=Homo sapiens OX=9606 GN=TTPAL PE=1 SV=2","TTPAL",1.021467422,0.863485951,"nochange",2564.38,2650.14,3264.84,2695.03,2597.69,3368.67,0.897643335,0.927663025,1.142834473,0.943376457,0.909303269,1.179179441,"cytoplasm",{"$nulls":6},"PF03765; PF00650","PF03765 CRAL/TRIO"," N-terminal domain; PF00650 CRAL/TRIO domain","I","KOG1471","Phosphatidylinositol transfer protein SEC14 and related proteins"]
["Q9BVG4","Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1","PBDC1",1.01621408,0.561088491,"nochange",52002.4,52586.9,53538.7,52426.2,52196.1,56069.6,0.978654093,0.989654034,1.007566341,0.986629756,0.982299411,1.055196366,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm;",{"$nulls":3},"S","KOG4093","Uncharacterized conserved protein"]
["Q9C073","Protein FAM117A OS=Homo sapiens OX=9606 GN=FAM117A PE=1 SV=1","FAM117A",2.036609056,1.76336E-4,"up",19311.8,20938.9,17816.9,37816.8,39201.6,41242.6,0.657129927,0.712495874,0.606262399,1.286806565,1.333927678,1.403377558,"nucleus"]
["Q9H098","Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1","FAM107B",1.272907719,0.046264888,"nochange",3428.58,4318.9,4258.08,5375.83,5226.78,4679.36,0.75387842,0.949642566,0.936269424,1.182041028,1.149267816,1.028900747,"nucleus",{"$nulls":3},"GO:0003008 system process; GO:0007600 sensory perception; GO:0007605 sensory perception of sound; GO:0032501 multicellular organismal process; GO:0050877 nervous system process; GO:0050954 sensory perception of mechanical stimulus;"]
["Q9H0Q0","CYFIP-related Rac1 interactor A OS=Homo sapiens OX=9606 GN=CYRIA PE=2 SV=1","CYRIA",1.277643569,0.061580206,"nochange",6488.08,7787.55,8677.9,10714.3,9287.45,9324.68,0.744615719,0.89375164,0.995934197,1.229645164,1.065890257,1.070163022,"cytoplasm",{"$nulls":4},"GO:0005622 intracellular anatomical structure;","GO:0005488 binding; GO:0005515 protein binding;","PF07159","PF07159 CYRIA/CYRIB Rac1 binding domain","S","KOG3951","Uncharacterized conserved protein"]
["Q9H4I3","TraB domain-containing protein OS=Homo sapiens OX=9606 GN=TRABD PE=1 SV=1","TRABD",0.825820453,0.005742973,"down",11099.1,11382.1,12191.7,9892.79,9563.19,9177.61,1.05193954,1.078761435,1.155492904,0.937609082,0.906370579,0.869826459,"nucleus",{"$nulls":8},"T","KOG2860","Uncharacterized conserved protein"," contains TraB domain"]
["Q9H8W3","Protein FAM204A OS=Homo sapiens OX=9606 GN=FAM204A PE=1 SV=1","FAM204A",0.93180936,0.757301725,"nochange",2215.14,1503.21,"NA",1944.96,1587.38,1664.85,1.242291549,0.843028016,"NA",1.0907696,0.890232112,0.933678723,"nucleus"]
["Q9H9A6","Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1","LRRC40",0.606267524,2.4075E-4,"down",37865,39375,39026,24247.2,21724.7,24516.4,1.216518174,1.265031113,1.25381852,0.779008569,0.697966258,0.787657366,"cytoplasm",{"$nulls":3},"GO:0006810 transport; GO:0006897 endocytosis; GO:0006909 phagocytosis; GO:0007154 cell communication; GO:0007165 signal transduction; GO:0009987 cellular process; GO:0016192 vesicle-mediated transport; GO:0023052 signaling; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050896 response to stimulus; GO:0051179 localization; GO:0051234 establishment of localization; GO:0051716 cellular response to stimulus; GO:0065007 biological regulation; GO:0098657 import into cell;","GO:0005886 plasma membrane; GO:0016020 membrane; GO:0071944 cell periphery;",{"$nulls":3},"S","KOG0472","Leucine-rich repeat protein"]
["Q9HAH7","Probable fibrosin-1 OS=Homo sapiens OX=9606 GN=FBRS PE=1 SV=3","FBRS",1.056176929,0.952827412,"nochange",1082.31,1183.21,679.212,718.825,1742.11,649.223,1.072498427,1.172483728,0.673054672,0.712308564,1.726317076,0.643337534,"cytoplasm","nucleus",{"$nulls":3},"GO:0008284 positive regulation of cell population proliferation; GO:0009966 regulation of signal transduction; GO:0010469 regulation of signaling receptor activity; GO:0010646 regulation of cell communication; GO:0023051 regulation of signaling; GO:0042127 regulation of cell population proliferation; GO:0048145 regulation of fibroblast proliferation; GO:0048146 positive regulation of fibroblast proliferation; GO:0048518 positive regulation of biological process; GO:0048522 positive regulation of cellular process; GO:0048583 regulation of response to stimulus; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0065007 biological regulation; GO:0065009 regulation of molecular function;","GO:0005576 extracellular region; GO:0005615 extracellular space;","GO:0005102 signaling receptor binding; GO:0005488 binding; GO:0005515 protein binding; GO:0008083 growth factor activity; GO:0030545 signaling receptor regulator activity; GO:0048018 receptor ligand activity; GO:0098772 molecular function regulator;"]
["Q9NRP4","Succinate dehydrogenase assembly factor 3"," mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1","SDHAF3",0.883948532,0.411604952,"nochange",5378.58,4782.63,"NA",4428.88,3731.36,5312.74,1.13788118,1.011803239,"NA",0.936964626,0.789398748,1.123952207,"mitochondria",{"$nulls":3},"GO:0006082 organic acid metabolic process; GO:0006105 succinate metabolic process; GO:0006109 regulation of carbohydrate metabolic process; GO:0006111 regulation of gluconeogenesis; GO:0006950 response to stress; GO:0006979 response to oxidative stress; GO:0006996 organelle organization; GO:0007005 mitochondrion organization; GO:0008152 metabolic process; GO:0009628 response to abiotic stimulus; GO:0009889 regulation of biosynthetic process; GO:0009987 cellular process; GO:0010675 regulation of cellular carbohydrate metabolic process; GO:0010906 regulation of glucose metabolic process; GO:0016043 cellular component organization; GO:0019222 regulation of metabolic process; GO:0019752 carboxylic acid metabolic process; GO:0022607 cellular component assembly; GO:0031323 regulation of cellular metabolic process; GO:0032501 multicellular organismal process; GO:0033108 mitochondrial respiratory chain complex assembly; GO:0034552 respiratory chain complex II assembly; GO:0034553 mitochondrial respiratory chain complex II assembly; GO:0036296 response to increased oxygen levels; GO:0043255 regulation of carbohydrate biosynthetic process; GO:0043436 oxoacid metabolic process; GO:0043648 dicarboxylic acid metabolic process; GO:0043933 protein-containing complex organization; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044281 small molecule metabolic process; GO:0050789 regulation of biological process; GO:0050794 regulation of cellular process; GO:0050879 multicellular organismal movement; GO:0050881 musculoskeletal movement; GO:0050896 response to stimulus; GO:0055093 response to hyperoxia; GO:0062012 regulation of small molecule metabolic process; GO:0065003 protein-containing complex assembly; GO:0065007 biological regulation; GO:0070482 response to oxygen levels; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:0080090 regulation of primary metabolic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005739 mitochondrion; GO:0005740 mitochondrial envelope; GO:0005758 mitochondrial intermembrane space; GO:0031967 organelle envelope; GO:0031970 organelle envelope lumen; GO:0031974 membrane-enclosed lumen; GO:0031975 envelope; GO:0043226 organelle; GO:0043227 membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043231 intracellular membrane-bounded organelle; GO:0043233 organelle lumen; GO:0070013 intracellular organelle lumen;",{"$nulls":3},"S","KOG4100","Uncharacterized conserved protein","WP4920 MITOCHONDRIAL COMPLEX II ASSEMBLY","http://www.wikipathways.org/instance/WP4920_r117791"]
["Q9NSG2","Uncharacterized protein C1orf112 OS=Homo sapiens OX=9606 GN=C1orf112 PE=1 SV=1","C1orf112",0.381411043,0.000401582,"down",13588.2,15803.5,12573,4742.29,5621.96,5641.55,1.406391182,1.635676767,1.301317049,0.490831371,0.581878024,0.583905607,"cytoplasm"]
["Q9NU23","LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1","LYRM2",1.363790689,0.054126344,"nochange",10154.7,7125.93,8314.72,11766.6,12712.6,10427.5,1.007043563,0.706679856,0.824572391,1.166895998,1.260711001,1.034097192,"mitochondria"]
["Q9NUJ7","PI-PLC X domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PLCXD1 PE=2 SV=1","PLCXD1",1.802991639,0.003957765,"up",3107.78,3993.33,2938.87,5641.59,6296.7,6163.71,0.662593037,0.851396384,0.626580646,1.202813022,1.342485497,1.314131415,"cytoplasm",{"$nulls":8},"T","KOG4306","Glycosylphosphatidylinositol-specific phospholipase C"]
["Q9NX00","Transmembrane protein 160 OS=Homo sapiens OX=9606 GN=TMEM160 PE=1 SV=1","TMEM160",1.042864022,0.460061002,"nochange",24595,24170.1,20801.4,23594.7,24374.7,24579,1.038385138,1.020446132,0.878221777,0.996153113,1.029084213,1.037709628,"mitochondria"]
["Q9P1F3","Costars family protein ABRACL OS=Homo sapiens OX=9606 GN=ABRACL PE=1 SV=1","ABRACL",1.335463733,0.332854542,"nochange",4018.96,2833.74,2976.44,6286.01,3623.59,3216.86,1.050452177,0.74066633,0.777964418,1.643000401,0.947112687,0.840803987,"cytoplasm",{"$nulls":6},"PF14705","PF14705 Costars","S","KOG3376","Uncharacterized conserved protein"]
["Q9UNX3","60S ribosomal protein L26-like 1 OS=Homo sapiens OX=9606 GN=RPL26L1 PE=1 SV=1","RPL26L1",0.648107364,0.000627946,"down",223698,209705,224991,136358,153425,136927,1.236921069,1.159547841,1.244070614,0.753981185,0.848351863,0.757127427,"nucleus","K02898","RP-L26e; large subunit ribosomal protein L26e","hsa03010 Ribosome; hsa05171 Coronavirus disease - COVID-19","GO:0002181 cytoplasmic translation; GO:0006412 translation; GO:0006518 peptide metabolic process; GO:0006807 nitrogen compound metabolic process; GO:0008152 metabolic process; GO:0009058 biosynthetic process; GO:0009059 macromolecule biosynthetic process; GO:0009987 cellular process; GO:0010467 gene expression; GO:0019538 protein metabolic process; GO:0022613 ribonucleoprotein complex biogenesis; GO:0034641 cellular nitrogen compound metabolic process; GO:0034645 cellular macromolecule biosynthetic process; GO:0042254 ribosome biogenesis; GO:0042273 ribosomal large subunit biogenesis; GO:0043043 peptide biosynthetic process; GO:0043170 macromolecule metabolic process; GO:0043603 cellular amide metabolic process; GO:0043604 amide biosynthetic process; GO:0044085 cellular component biogenesis; GO:0044237 cellular metabolic process; GO:0044238 primary metabolic process; GO:0044249 cellular biosynthetic process; GO:0044260 cellular macromolecule metabolic process; GO:0044267 cellular protein metabolic process; GO:0044271 cellular nitrogen compound biosynthetic process; GO:0071704 organic substance metabolic process; GO:0071840 cellular component organization or biogenesis; GO:1901564 organonitrogen compound metabolic process; GO:1901566 organonitrogen compound biosynthetic process; GO:1901576 organic substance biosynthetic process;","GO:0005622 intracellular anatomical structure; GO:0005737 cytoplasm; GO:0005829 cytosol; GO:0005840 ribosome; GO:0015934 large ribosomal subunit; GO:0022625 cytosolic large ribosomal subunit; GO:0022626 cytosolic ribosome; GO:0032991 protein-containing complex; GO:0043226 organelle; GO:0043228 non-membrane-bounded organelle; GO:0043229 intracellular organelle; GO:0043232 intracellular non-membrane-bounded organelle; GO:0044391 ribosomal subunit; GO:1990904 ribonucleoprotein complex;","GO:0003676 nucleic acid binding; GO:0003723 RNA binding; GO:0003735 structural constituent of ribosome; GO:0005198 structural molecule activity; GO:0005488 binding; GO:0097159 organic cyclic compound binding; GO:1901363 heterocyclic compound binding;",null,null,"J","KOG3401","60S ribosomal protein L26",{"$nulls":3},"R-HSA-1266738 Developmental Biology;R-HSA-1430728 Metabolism;R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression;R-HSA-156842 Eukaryotic Translation Elongation;R-HSA-156902 Peptide chain elongation;R-HSA-1643685 Disease;R-HSA-168255 Influenza Infection;R-HSA-168273 Influenza Viral RNA Transcription and Replication;R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane;R-HSA-192823 Viral mRNA Translation;R-HSA-2262752 Cellular responses to stress;R-HSA-2408522 Selenoamino acid metabolism;R-HSA-2408557 Selenocysteine synthesis;R-HSA-376176 Signaling by ROBO receptors;R-HSA-392499 Metabolism of proteins;R-HSA-422475 Axon guidance;R-HSA-5663205 Infectious disease;R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol;R-HSA-71291 Metabolism of amino acids and derivatives;R-HSA-72312 rRNA processing;R-HSA-72613 Eukaryotic Translation Initiation;R-HSA-72689 Formation of a pool of free 40S subunits;R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit;R-HSA-72737 Cap-dependent Translation Initiation;R-HSA-72764 Eukaryotic Translation Termination;R-HSA-72766 Translation;R-HSA-8868773 rRNA processing in the nucleus and cytosol;R-HSA-8953854 Metabolism of RNA;R-HSA-8953897 Cellular responses to stimuli;R-HSA-9010553 Regulation of expression of SLITs and ROBOs;R-HSA-927802 Nonsense-Mediated Decay (NMD);R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency;R-HSA-9675108 Nervous system development;R-HSA-9711097 Cellular response to starvation;R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC);R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","https://reactome.org/PathwayBrowser/#/R-HSA-1266738;https://reactome.org/PathwayBrowser/#/R-HSA-1430728;https://reactome.org/PathwayBrowser/#/R-HSA-156827;https://reactome.org/PathwayBrowser/#/R-HSA-156842;https://reactome.org/PathwayBrowser/#/R-HSA-156902;https://reactome.org/PathwayBrowser/#/R-HSA-1643685;https://reactome.org/PathwayBrowser/#/R-HSA-168255;https://reactome.org/PathwayBrowser/#/R-HSA-168273;https://reactome.org/PathwayBrowser/#/R-HSA-1799339;https://reactome.org/PathwayBrowser/#/R-HSA-192823;https://reactome.org/PathwayBrowser/#/R-HSA-2262752;https://reactome.org/PathwayBrowser/#/R-HSA-2408522;https://reactome.org/PathwayBrowser/#/R-HSA-2408557;https://reactome.org/PathwayBrowser/#/R-HSA-376176;https://reactome.org/PathwayBrowser/#/R-HSA-392499;https://reactome.org/PathwayBrowser/#/R-HSA-422475;https://reactome.org/PathwayBrowser/#/R-HSA-5663205;https://reactome.org/PathwayBrowser/#/R-HSA-6791226;https://reactome.org/PathwayBrowser/#/R-HSA-71291;https://reactome.org/PathwayBrowser/#/R-HSA-72312;https://reactome.org/PathwayBrowser/#/R-HSA-72613;https://reactome.org/PathwayBrowser/#/R-HSA-72689;https://reactome.org/PathwayBrowser/#/R-HSA-72706;https://reactome.org/PathwayBrowser/#/R-HSA-72737;https://reactome.org/PathwayBrowser/#/R-HSA-72764;https://reactome.org/PathwayBrowser/#/R-HSA-72766;https://reactome.org/PathwayBrowser/#/R-HSA-8868773;https://reactome.org/PathwayBrowser/#/R-HSA-8953854;https://reactome.org/PathwayBrowser/#/R-HSA-8953897;https://reactome.org/PathwayBrowser/#/R-HSA-9010553;https://reactome.org/PathwayBrowser/#/R-HSA-927802;https://reactome.org/PathwayBrowser/#/R-HSA-9633012;https://reactome.org/PathwayBrowser/#/R-HSA-9675108;https://reactome.org/PathwayBrowser/#/R-HSA-9711097;https://reactome.org/PathwayBrowser/#/R-HSA-975956;https://reactome.org/PathwayBrowser/#/R-HSA-975957"]
["Q9Y546","Leucine-rich repeat-containing protein 42 OS=Homo sapiens OX=9606 GN=LRRC42 PE=1 SV=1","LRRC42",0.785499501,0.398438611,"nochange",2998.78,"NA",2169.18,1712.24,"NA",2347.19,1.299947222,"NA",0.940322236,0.742242389,"NA",1.017488152,"nucleus"]
["A0A096LP01","Small integral membrane protein 26 OS=Homo sapiens OX=9606 GN=SMIM26 PE=3 SV=1","SMIM26",1.461395566,0.032835977,"nochange",906.096,792.279,1017.44,1250.66,1395.26,"NA",0.844965296,0.738827077,0.948797358,1.166282929,1.30112734,"NA","mitochondria"]
["E9PRG8","Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=4 SV=2","C11orf98",0.905307092,0.620915754,"nochange",4761.14,7641.07,6089.46,6740.12,5274.98,4725.54,0.81081371,1.301260689,1.037024254,1.1478305,0.898319753,0.804751094,"nucleus"]
["Q96BQ5","Coiled-coil domain-containing protein 127 OS=Homo sapiens OX=9606 GN=CCDC127 PE=1 SV=1","CCDC127",1.176834604,0.116276992,"nochange",8354.39,8234.83,7957.22,10837.2,9743.16,8306.74,0.938106291,0.924681015,0.893508459,1.2168986,1.094049917,0.932755719,"cytoplasm","nucleus"]

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["geneSymbol","regulated_type"]
["ARVCF","Up"]
["DNM1L","Up"]
["DDX3X","Up"]
["UBE2C","Up"]
["ADAM10","Up"]
["HAT1","Up"]
["PPP1R12A","Up"]
["U2SURP","Up"]
["DHX15","Up"]
["RNMT","Up"]
["ADCY6","Up"]
["HNRNPR","Up"]
["PRPF3","Up"]
["TXNL1","Up"]
["PRC1","Up"]
["AP1G1","Up"]
["STRN","Up"]
["AKAP8","Up"]
["AQR","Up"]
["KDM1A","Up"]
["CTNND1","Up"]
["DPM1","Up"]
["PQBP1","Up"]
["ROCK2","Up"]
["ZC3H11A","Up"]
["DNAJB6","Up"]
["HMMR","Up"]
["NCOR1","Up"]
["CS","Up"]
["SRSF10","Up"]
["ATP6AP2","Up"]
["PDE5A","Up"]
["PHF14","Up"]
["SEC31A","Up"]
["SCAF4","Up"]
["NDUFA3","Up"]
["ZRANB2","Up"]
["GOSR1","Up"]
["SEC24B","Up"]
["ACSL3","Up"]
["STAU1","Up"]
["CA1","Up"]
["LMNA","Up"]
["SOD2","Up"]
["PRKCB","Up"]
["ENO1","Up"]
["GPI","Up"]
["TPM3","Up"]
["DBI","Up"]
["P4HB","Up"]
["CTSB","Up"]
["HNRNPC","Up"]
["HMBS","Up"]
["CALM1","Up"]
["PRKAR1A","Up"]
["TFPI","Up"]
["ESD","Up"]
["ACP2","Up"]
["F5","Up"]
["MYL4","Up"]
["RNH1","Up"]
["ALAD","Up"]
["COX7A2","Up"]
["PKM","Up"]
["POU2F1","Up"]
["GLUL","Up"]
["CD46","Up"]
["RPA2","Up"]
["GATA1","Up"]
["CREB1","Up"]
["UBTF","Up"]
["DDX5","Up"]
["SON","Up"]
["EIF2AK2","Up"]
["RAB4A","Up"]
["ATP6V1B2","Up"]
["ATP6V1C1","Up"]
["PCMT1","Up"]
["SCP2","Up"]
["HNRNPA2B1","Up"]
["PTGS1","Up"]
["SP100","Up"]
["BRD2","Up"]
["ATP5F1A","Up"]
["MSN","Up"]
["DDX6","Up"]
["MGAT1","Up"]
["PTBP1","Up"]
["PTPN6","Up"]
["TKT","Up"]
["BLVRB","Up"]
["PDIA3","Up"]
["NKTR","Up"]
["YWHAB","Up"]
["DCTD","Up"]
["DEK","Up"]
["CUX1","Up"]
["PAFAH1B1","Up"]
["VDAC2","Up"]
["ATRX","Up"]
["BAG6","Up"]
["GNPDA1","Up"]
["UTRN","Up"]
["GCLC","Up"]
["IDH2","Up"]
["PITPNB","Up"]
["SRP9","Up"]
["VPS41","Up"]
["CLK1","Up"]
["PPT1","Up"]
["RAB9A","Up"]
["SSR4","Up"]
["MECP2","Up"]
["HSD17B4","Up"]
["NDUFA8","Up"]
["HNRNPM","Up"]
["KPNA1","Up"]
["MSH6","Up"]
["PLK1","Up"]
["SUB1","Up"]
["AK2","Up"]
["NAPA","Up"]
["TMBIM6","Up"]
["CTBP2","Up"]
["AP3S2","Up"]
["MYL6","Up"]
["ATP6V0D1","Up"]
["UFM1","Up"]
["PSMC5","Up"]
["CNBP","Up"]
["YPEL5","Up"]
["RAP1A","Up"]
["PPIA","Up"]
["GNAS","Up"]
["SLC35B1","Up"]
["PRAME","Up"]
["DLK1","Up"]
["SLC25A3","Up"]
["TIAL1","Up"]
["GALK2","Up"]
["OCRL","Up"]
["KIF23","Up"]
["AKR1C1","Up"]
["PTPN11","Up"]
["PRDX1","Up"]
["SRSF4","Up"]
["CD47","Up"]
["PPID","Up"]
["SMARCB1","Up"]
["DNAJC3","Up"]
["PPP2R5C","Up"]
["PPIG","Up"]
["OS9","Up"]
["GOLGA4","Up"]
["TDG","Up"]
["LAPTM5","Up"]
["MTMR3","Up"]
["DYRK1A","Up"]
["MOGS","Up"]
["DDX39B","Up"]
["CIRBP","Up"]
["UBAP2L","Up"]
["PUM1","Up"]
["MEF2D","Up"]
["CHD4","Up"]
["DRAP1","Up"]
["ZNF638","Up"]
["NUMA1","Up"]
["SLMAP","Up"]
["GAPVD1","Up"]
["PSMD6","Up"]
["ACOX1","Up"]
["PLEC","Up"]
["RBBP5","Up"]
["TOMM20","Up"]
["SEC23B","Up"]
["TSN","Up"]
["SF1","Up"]
["MYLK","Up"]
["CCDC6","Up"]
["MAPK14","Up"]
["NRF1","Up"]
["GUK1","Up"]
["ALG11","Up"]
["ACSM3","Up"]
["USP39","Up"]
["SETMAR","Up"]
["FAM76B","Up"]
["EARS2","Up"]
["ATAT1","Up"]
["ARHGAP17","Up"]
["HMBOX1","Up"]
["NFRKB","Up"]
["FBXO38","Up"]
["FIP1L1","Up"]
["MPRIP","Up"]
["PIK3AP1","Up"]
["MED13L","Up"]
["CBLL1","Up"]
["DDX46","Up"]
["MOB1B","Up"]
["ATG9A","Up"]
["CCDC91","Up"]
["PCGF5","Up"]
["PATL1","Up"]
["LUZP1","Up"]
["ERC1","Up"]
["PHF6","Up"]
["SUGP2","Up"]
["SRRM1","Up"]
["SPART","Up"]
["CA13","Up"]
["STAG2","Up"]
["CISD2","Up"]
["CPSF7","Up"]
["OTUD6B","Up"]
["SPC24","Up"]
["PHC3","Up"]
["MCU","Up"]
["ARID1B","Up"]
["COQ8A","Up"]
["NEK7","Up"]
["PNISR","Up"]
["ABHD5","Up"]
["CANT1","Up"]
["ATXN2L","Up"]
["DHX38","Up"]
["ANP32B","Up"]
["TFG","Up"]
["HDAC2","Up"]
["DPF2","Up"]
["NEO1","Up"]
["EMG1","Up"]
["UBE2E3","Up"]
["TMBIM1","Up"]
["FUBP1","Up"]
["OTULIN","Up"]
["MRRF","Up"]
["YIPF6","Up"]
["EDC3","Up"]
["DCUN1D1","Up"]
["LRR1","Up"]
["RPRD1A","Up"]
["AGAP3","Up"]
["QKI","Up"]
["CIC","Up"]
["RANBP9","Up"]
["SPEN","Up"]
["PFDN5","Up"]
["EYA3","Up"]
["SERPINI1","Up"]
["PIP5K1A","Up"]
["PRMT1","Up"]
["LXN","Up"]
["RBM42","Up"]
["ANP32E","Up"]
["NTMT1","Up"]
["PAPOLG","Up"]
["NUSAP1","Up"]
["POLDIP3","Up"]
["FUT8","Up"]
["OSBPL8","Up"]
["OSBPL6","Up"]
["TRIM5","Up"]
["CEP44","Up"]
["MFF","Up"]
["CLPB","Up"]
["UNC45A","Up"]
["ALG2","Up"]
["CCDC134","Up"]
["BCAS3","Up"]
["GOPC","Up"]
["WDR6","Up"]
["TIMMDC1","Up"]
["C1orf109","Up"]
["OCIAD1","Up"]
["LYAR","Up"]
["CWC25","Up"]
["ANKRD10","Up"]
["NUDT4","Up"]
["ITSN2","Up"]
["MYEF2","Up"]
["KANSL3","Up"]
["SUCLA2","Up"]
["BIN2","Up"]
["CNOT8","Up"]
["CHORDC1","Up"]
["DPP7","Up"]
["SAP30BP","Up"]
["PUF60","Up"]
["BAZ2B","Up"]
["LNPEP","Up"]
["DDX41","Up"]
["PTBP2","Up"]
["FBXW11","Up"]
["TNIK","Up"]
["ACIN1","Up"]
["CORO1C","Up"]
["AKAP8L","Up"]
["MAGED2","Up"]
["CDK11A","Up"]
["LIPT1","Up"]
["POFUT2","Up"]
["THRAP3","Up"]
["SUGT1","Up"]
["NOSIP","Up"]
["SH3GLB1","Up"]
["DHRS7","Up"]
["USP15","Up"]
["RAPGEF2","Up"]
["YTHDF2","Up"]
["GTF3C3","Up"]
["RBM8A","Up"]
["FKBP7","Up"]
["SPCS1","Up"]
["PRSS21","Up"]
["IGF2BP2","Up"]
["MAU2","Up"]
["VWA5A","Up"]
["ATP5MG","Up"]
["NDUFB2","Up"]
["ZNF30","Up"]
["RBM26","Up"]
["PDXDC1","Up"]
["DGLUCY","Up"]
["PRPF39","Up"]
["KIAA1191","Up"]
["TM9SF2","Up"]
["BTBD10","Up"]
["COA1","Up"]
["CPVL","Up"]
["COX16","Up"]
["PHF20L1","Up"]
["C5orf22","Up"]
["SPATS2","Up"]
["GTPBP8","Up"]
["CEBPZOS","Up"]
["TRIQK","Up"]
["TTC13","Up"]
["UBA6","Down"]
["NBAS","Down"]
["VWA8","Down"]
["WDR91","Down"]
["CNOT1","Down"]
["RCCD1","Down"]
["SMCHD1","Down"]
["MIF4GD","Down"]
["MYO1G","Down"]
["GPR89A","Down"]
["AGPS","Down"]
["KIF2A","Down"]
["SNAP23","Down"]
["STXBP3","Down"]
["AP4M1","Down"]
["NFKBIE","Down"]
["ATOX1","Down"]
["EEF2K","Down"]
["IGF2BP3","Down"]
["MANBA","Down"]
["BIN1","Down"]
["KRIT1","Down"]
["PPP6C","Down"]
["SCD","Down"]
["FCHO1","Down"]
["CIT","Down"]
["CCS","Down"]
["ACOT8","Down"]
["CHEK1","Down"]
["NRP1","Down"]
["POLR3A","Down"]
["SCAMP3","Down"]
["VPS26C","Down"]
["XPO1","Down"]
["SEC16A","Down"]
["SYNJ2","Down"]
["RER1","Down"]
["SPTLC2","Down"]
["OGT","Down"]
["PMM2","Down"]
["INPPL1","Down"]
["NVL","Down"]
["ABCC4","Down"]
["RRP8","Down"]
["PHGDH","Down"]
["AKR7A2","Down"]
["RAD51C","Down"]
["XRCC3","Down"]
["TRAPPC3","Down"]
["LIAS","Down"]
["SLC25A17","Down"]
["RRP9","Down"]
["CFAP410","Down"]
["IDH3B","Down"]
["AHCYL1","Down"]
["ORC5","Down"]
["ORC4","Down"]
["ZFC3H1","Down"]
["MCM3AP","Down"]
["KIF1B","Down"]
["LY75","Down"]
["OGA","Down"]
["NEMF","Down"]
["EXOC3","Down"]
["PRMT3","Down"]
["LPXN","Down"]
["PFKFB2","Down"]
["KIN","Down"]
["NBN","Down"]
["ABCB7","Down"]
["CBFA2T3","Down"]
["N4BP1","Down"]
["HIP1R","Down"]
["OBSL1","Down"]
["DNAJC13","Down"]
["PPP6R2","Down"]
["RTN2","Down"]
["FLNB","Down"]
["CDC45","Down"]
["MTX2","Down"]
["KATNA1","Down"]
["ECI2","Down"]
["EED","Down"]
["MYCBP2","Down"]
["GCAT","Down"]
["ERAL1","Down"]
["TOM1L1","Down"]
["WDHD1","Down"]
["CAPN15","Down"]
["AP1G2","Down"]
["RBBP9","Down"]
["FLOT1","Down"]
["CLPX","Down"]
["SRP72","Down"]
["RECQL4","Down"]
["RECQL5","Down"]
["LTN1","Down"]
["IPO13","Down"]
["DDHD2","Down"]
["ERLIN2","Down"]
["FRYL","Down"]
["GLS","Down"]
["HAUS5","Down"]
["USP19","Down"]
["UBR5","Down"]
["UBE4B","Down"]
["SMC2","Down"]
["ATG7","Down"]
["PGM3","Down"]
["PARN","Down"]
["FMNL1","Down"]
["NADK","Down"]
["SFT2D2","Down"]
["PCNT","Down"]
["YEATS4","Down"]
["STAMBP","Down"]
["HERC2","Down"]
["MPIG6B","Down"]
["ABHD16A","Down"]
["CHEK2","Down"]
["DHFR","Down"]
["ASL","Down"]
["NTRK1","Down"]
["ITGB2","Down"]
["UROD","Down"]
["HEXA","Down"]
["LYN","Down"]
["PFKM","Down"]
["SRPRA","Down"]
["ASNS","Down"]
["ITGA2B","Down"]
["PDHA1","Down"]
["PTPRC","Down"]
["HCK","Down"]
["SRP19","Down"]
["POLA1","Down"]
["UMPS","Down"]
["ACADM","Down"]
["TOP2A","Down"]
["PC","Down"]
["MTHFD1","Down"]
["IGF2R","Down"]
["ITGA4","Down"]
["APEH","Down"]
["PRKAR2A","Down"]
["HCLS1","Down"]
["FDPS","Down"]
["TRIM27","Down"]
["ANPEP","Down"]
["UCHL3","Down"]
["HPGD","Down"]
["TCF3","Down"]
["NQO2","Down"]
["ANK1","Down"]
["PECAM1","Down"]
["CD36","Down"]
["PLCG2","Down"]
["FAH","Down"]
["AMD1","Down"]
["CTPS1","Down"]
["TCP1","Down"]
["PTPN1","Down"]
["ERCC2","Down"]
["PTPRA","Down"]
["CD53","Down"]
["CD33","Down"]
["IMPDH1","Down"]
["GART","Down"]
["ATP2B4","Down"]
["DTYMK","Down"]
["CCNC","Down"]
["ITGB7","Down"]
["IVD","Down"]
["RPL10","Down"]
["CAD","Down"]
["CANX","Down"]
["PPP2R1B","Down"]
["CDC27","Down"]
["ADSL","Down"]
["SLC7A1","Down"]
["ARRB2","Down"]
["PYCR1","Down"]
["GTF2H1","Down"]
["CTH","Down"]
["ABCC1","Down"]
["SHMT1","Down"]
["TIE1","Down"]
["COPB2","Down"]
["ATP7B","Down"]
["NUP62","Down"]
["BRCA1","Down"]
["IGHMBP2","Down"]
["RPL13A","Down"]
["MLH1","Down"]
["USP8","Down"]
["PEX19","Down"]
["UBA7","Down"]
["TMPO","Down"]
["STAT1","Down"]
["STAT6","Down"]
["MTOR","Down"]
["PI4KA","Down"]
["HELZ","Down"]
["NCAPD3","Down"]
["LRPPRC","Down"]
["MTHFR","Down"]
["GRK6","Down"]
["SYK","Down"]
["TSFM","Down"]
["MAPK8","Down"]
["IREB2","Down"]
["LSS","Down"]
["GSS","Down"]
["CCT5","Down"]
["HARS2","Down"]
["CASP4","Down"]
["RANBP2","Down"]
["LIG3","Down"]
["VASP","Down"]
["HLCS","Down"]
["KNTC1","Down"]
["LRBA","Down"]
["DAP3","Down"]
["RENBP","Down"]
["STAT5B","Down"]
["CLCN6","Down"]
["ADCY7","Down"]
["STAT2","Down"]
["RBM5","Down"]
["NUP98","Down"]
["RABGGTB","Down"]
["COPA","Down"]
["TTC3","Down"]
["POLG","Down"]
["ATXN3","Down"]
["PMS1","Down"]
["PRKAG1","Down"]
["ATP1B3","Down"]
["SLC12A2","Down"]
["DRG2","Down"]
["CASP9","Down"]
["FCGRT","Down"]
["CORO7","Down"]
["ABCE1","Down"]
["PSME3","Down"]
["RPL27","Down"]
["SH3BP2","Down"]
["PSPH","Down"]
["RBM6","Down"]
["GTF2I","Down"]
["HSPG2","Down"]
["ARHGAP4","Down"]
["PLCB2","Down"]
["RUNX1","Down"]
["XPC","Down"]
["DHODH","Down"]
["PLOD1","Down"]
["TOP2B","Down"]
["ERCC6","Down"]
["PTK2","Down"]
["FPGS","Down"]
["BAX","Down"]
["SLC20A2","Down"]
["GOLGA3","Down"]
["NSUN2","Down"]
["NCBP1","Down"]
["WASHC5","Down"]
["NUP160","Down"]
["TFCP2","Down"]
["GRSF1","Down"]
["CDC16","Down"]
["COASY","Down"]
["ACACA","Down"]
["USP4","Down"]
["EIF2B5","Down"]
["SELENBP1","Down"]
["MAD2L1","Down"]
["SKP2","Down"]
["GRB10","Down"]
["DYNC1I2","Down"]
["ORC2","Down"]
["ILK","Down"]
["MTM1","Down"]
["ASAH1","Down"]
["RIPK1","Down"]
["NAE1","Down"]
["PEX6","Down"]
["PWP1","Down"]
["CUL4A","Down"]
["CKAP5","Down"]
["UBE4A","Down"]
["MLEC","Down"]
["ZMYM3","Down"]
["DYNC1H1","Down"]
["EIF4A2","Down"]
["FLOT2","Down"]
["HLTF","Down"]
["ITPR2","Down"]
["IRF3","Down"]
["RRP1B","Down"]
["LBR","Down"]
["PSME4","Down"]
["NAA25","Down"]
["FASTKD3","Down"]
["EMC2","Down"]
["ACAP1","Down"]
["IQCB1","Down"]
["KIF14","Down"]
["STK38","Down"]
["TERF2","Down"]
["RHOH","Down"]
["HERC1","Down"]
["TBCE","Down"]
["STXBP2","Down"]
["EZH2","Down"]
["PDCD2","Down"]
["PCK2","Down"]
["INF2","Down"]
["PDS5A","Down"]
["WASHC4","Down"]
["EML3","Down"]
["CHD9","Down"]
["PUS10","Down"]
["GON4L","Down"]
["TIMM50","Down"]
["GLYR1","Down"]
["LARP7","Down"]
["PREPL","Down"]
["GRIPAP1","Down"]
["PDCD4","Down"]
["FASTKD1","Down"]
["NOM1","Down"]
["PIGG","Down"]
["PPP6R3","Down"]
["PITRM1","Down"]
["AARS2","Down"]
["RABGAP1L","Down"]
["NUP188","Down"]
["VARS2","Down"]
["LDLRAP1","Down"]
["THEM4","Down"]
["FKBP15","Down"]
["ZFYVE27","Down"]
["STXBP5","Down"]
["DCAF8","Down"]
["TUT4","Down"]
["CROCC","Down"]
["PIK3R6","Down"]
["VPS53","Down"]
["CDC42BPA","Down"]
["MYSM1","Down"]
["ECPAS","Down"]
["ZMYM4","Down"]
["RNF123","Down"]
["RNF213","Down"]
["WASHC2A","Down"]
["ZFYVE26","Down"]
["INTS3","Down"]
["WWC2","Down"]
["TTC19","Down"]
["NADSYN1","Down"]
["ELP2","Down"]
["ALKBH2","Down"]
["TMEM214","Down"]
["DHX57","Down"]
["LPCAT3","Down"]
["TAF2","Down"]
["CTR9","Down"]
["DARS2","Down"]
["ATAD2","Down"]
["WDR74","Down"]
["LRSAM1","Down"]
["DHRS11","Down"]
["HSDL2","Down"]
["NBEAL2","Down"]
["VPS13C","Down"]
["USP34","Down"]
["UNC13D","Down"]
["DHX30","Down"]
["NDUFAF7","Down"]
["MICAL3","Down"]
["TRAPPC11","Down"]
["VPS35L","Down"]
["POGZ","Down"]
["ZFYVE16","Down"]
["TMC6","Down"]
["DHX29","Down"]
["AKNA","Down"]
["ARHGAP22","Down"]
["RBBP6","Down"]
["RABEPK","Down"]
["MTERF4","Down"]
["HUWE1","Down"]
["GALNT7","Down"]
["PRUNE1","Down"]
["PBRM1","Down"]
["SMG6","Down"]
["USP48","Down"]
["PPFIBP1","Down"]
["CHD1L","Down"]
["CCDC25","Down"]
["VRK2","Down"]
["C2CD5","Down"]
["RASAL3","Down"]
["TMC8","Down"]
["RIOX2","Down"]
["ZBTB8OS","Down"]
["CUL9","Down"]
["UBR2","Down"]
["CDAN1","Down"]
["CD302","Down"]
["DNAJC10","Down"]
["NELFCD","Down"]
["RHOT2","Down"]
["SYTL1","Down"]
["ANKRD13A","Down"]
["TRMT2A","Down"]
["KIAA0319L","Down"]
["MIER1","Down"]
["NUP93","Down"]
["CMTR1","Down"]
["ARMC10","Down"]
["ABHD12","Down"]
["CENPS","Down"]
["KDM8","Down"]
["ASCC3","Down"]
["ARRDC1","Down"]
["ARFGAP2","Down"]
["CGAS","Down"]
["ATP11C","Down"]
["SUMF2","Down"]
["MTMR14","Down"]
["DAGLB","Down"]
["TENT4B","Down"]
["FBXO22","Down"]
["DOCK8","Down"]
["USP32","Down"]
["NUP43","Down"]
["MOSPD2","Down"]
["DDX55","Down"]
["THOC2","Down"]
["SLC30A5","Down"]
["NPLOC4","Down"]
["PUM2","Down"]
["SHKBP1","Down"]
["CIP2A","Down"]
["RASGRP4","Down"]
["MICAL1","Down"]
["DCAF11","Down"]
["PIGO","Down"]
["NOC3L","Down"]
["SCARB1","Down"]
["NPRL2","Down"]
["HDAC7","Down"]
["NUP133","Down"]
["PDCD6IP","Down"]
["AFG1L","Down"]
["CHTF18","Down"]
["LMBR1","Down"]
["TSEN15","Down"]
["PHIP","Down"]
["RASSF5","Down"]
["MADD","Down"]
["PIBF1","Down"]
["PSMF1","Down"]
["TOPBP1","Down"]
["AP3S1","Down"]
["CNOT9","Down"]
["LARP4B","Down"]
["NUP205","Down"]
["NSMAF","Down"]
["AKAP1","Down"]
["CASP10","Down"]
["ARHGEF1","Down"]
["GPKOW","Down"]
["TNPO1","Down"]
["USP9X","Down"]
["USP7","Down"]
["PHKB","Down"]
["PIGT","Down"]
["ITFG2","Down"]
["TMEM230","Down"]
["RFT1","Down"]
["RAB37","Down"]
["PPWD1","Down"]
["TESC","Down"]
["CENPT","Down"]
["PYCR2","Down"]
["PPCDC","Down"]
["FOXRED1","Down"]
["NMD3","Down"]
["COQ8B","Down"]
["ASB9","Down"]
["L3HYPDH","Down"]
["CHFR","Down"]
["DAZAP1","Down"]
["CYFIP2","Down"]
["DDX11","Down"]
["THOC1","Down"]
["PGM2","Down"]
["ZNF274","Down"]
["SNF8","Down"]
["MYO19","Down"]
["TONSL","Down"]
["SCLY","Down"]
["FUBP3","Down"]
["RCC1L","Down"]
["LRCH3","Down"]
["AKR1E2","Down"]
["SPG11","Down"]
["ELMO2","Down"]
["TMX3","Down"]
["EXOC2","Down"]
["CNDP2","Down"]
["KIF16B","Down"]
["DHRS1","Down"]
["WDFY2","Down"]
["IPO9","Down"]
["LENG8","Down"]
["SMG1","Down"]
["XPO6","Down"]
["SPAG5","Down"]
["CAMKK2","Down"]
["PIGS","Down"]
["CLCC1","Down"]
["SRPK1","Down"]
["IWS1","Down"]
["OSBPL9","Down"]
["PCYT2","Down"]
["AGAP2","Down"]
["NUP88","Down"]
["KIF2C","Down"]
["DOK1","Down"]
["MTR","Down"]
["BARD1","Down"]
["APBA2","Down"]
["MIPEP","Down"]
["CIB1","Down"]
["CCT7","Down"]
["NCAPG","Down"]
["DDX50","Down"]
["ELAC2","Down"]
["WDR77","Down"]
["DPH2","Down"]
["HEPH","Down"]
["ADPGK","Down"]
["GINS3","Down"]
["YIPF4","Down"]
["CRACR2A","Down"]
["MTG1","Down"]
["DCUN1D5","Down"]
["TBCD","Down"]
["NDC1","Down"]
["MKNK1","Down"]
["MSTO1","Down"]
["DERL1","Down"]
["THUMPD3","Down"]
["PHF20","Down"]
["GNL3","Down"]
["NUP85","Down"]
["IFT27","Down"]
["TARS2","Down"]
["QTRT1","Down"]
["OSBPL1A","Down"]
["FANCD2","Down"]
["PANK2","Down"]
["WDR11","Down"]
["API5","Down"]
["TANC1","Down"]
["MTMR12","Down"]
["EGLN1","Down"]
["UBA5","Down"]
["ILKAP","Down"]
["BRD8","Down"]
["NT5C3A","Down"]
["ANAPC1","Down"]
["POLR3F","Down"]
["ASCC2","Down"]
["PPIL3","Down"]
["TAOK3","Down"]
["RAB3GAP2","Down"]
["DHX36","Down"]
["TRIT1","Down"]
["PIGU","Down"]
["WNK1","Down"]
["DEF6","Down"]
["HEATR1","Down"]
["HAUS4","Down"]
["REEP4","Down"]
["CIAO3","Down"]
["YTHDC2","Down"]
["C8orf33","Down"]
["ACAD9","Down"]
["ANKZF1","Down"]
["COG4","Down"]
["ELP3","Down"]
["TBC1D17","Down"]
["WDR41","Down"]
["PARVG","Down"]
["PARVB","Down"]
["NMRAL1","Down"]
["MCCC2","Down"]
["CYLD","Down"]
["NIT2","Down"]
["XPNPEP1","Down"]
["GPHN","Down"]
["PDLIM7","Down"]
["DDX21","Down"]
["AAAS","Down"]
["HELLS","Down"]
["SMC4","Down"]
["OLA1","Down"]
["MDN1","Down"]
["AGPAT5","Down"]
["TBC1D23","Down"]
["INTS9","Down"]
["TMEM30A","Down"]
["UQCC1","Down"]
["INTS7","Down"]
["FANCI","Down"]
["INTS13","Down"]
["PNPO","Down"]
["SDAD1","Down"]
["FANCL","Down"]
["PIH1D1","Down"]
["MRPL22","Down"]
["IRAK4","Down"]
["UTP6","Down"]
["STK26","Down"]
["EIF2AK4","Down"]
["WRAP73","Down"]
["GMPR2","Down"]
["DNMT3B","Down"]
["ORC3","Down"]
["COMMD3","Down"]
["MTRR","Down"]
["HDAC6","Down"]
["RPS6KB2","Down"]
["UBA2","Down"]
["ZMYM2","Down"]
["ADD3","Down"]
["TES","Down"]
["TUBGCP4","Down"]
["SRP68","Down"]
["USP25","Down"]
["SLC12A6","Down"]
["EIF2B4","Down"]
["MUTYH","Down"]
["CNOT7","Down"]
["NAGK","Down"]
["SLC25A13","Down"]
["DBNL","Down"]
["ANAPC7","Down"]
["ANAPC5","Down"]
["ANAPC4","Down"]
["PACSIN3","Down"]
["ACAD8","Down"]
["INTS6","Down"]
["ACSL5","Down"]
["ZMYND8","Down"]
["G3BP2","Down"]
["DUSP12","Down"]
["DIMT1","Down"]
["MINPP1","Down"]
["TFR2","Down"]
["MACF1","Down"]
["PHF8","Down"]
["USP24","Down"]
["DICER1","Down"]
["BAIAP2","Down"]
["MTMR6","Down"]
["TRAPPC4","Down"]
["CARD8","Down"]
["NISCH","Down"]
["PIKFYVE","Down"]
["SIK3","Down"]
["DIS3","Down"]
["TRAPPC8","Down"]
["ATP8A1","Down"]
["LAMTOR2","Down"]
["MTO1","Down"]
["TMX2","Down"]
["REXO2","Down"]
["UFC1","Down"]
["STRAP","Down"]
["RABGAP1","Down"]
["DOP1B","Down"]
["HBS1L","Down"]
["PLXND1","Down"]
["ZNF451","Down"]
["LAS1L","Down"]
["PRRC2C","Down"]
["OARD1","Down"]
["TRAPPC1","Down"]
["FLVCR1","Down"]
["PEX16","Down"]
["FHOD1","Down"]
["NPTN","Down"]
["AUP1","Down"]
["ARFGEF1","Down"]
["CAPN7","Down"]
["MRPS15","Down"]
["CTDSPL2","Down"]
["TBL3","Down"]
["TSR1","Down"]
["DOCK11","Down"]
["PRRC2B","Down"]
["RRP12","Down"]
["MRPL2","Down"]
["BROX","Down"]
["FAM91A1","Down"]
["GLT8D1","Down"]
["CWF19L1","Down"]
["FBXO42","Down"]
["TRIM65","Down"]
["WDFY4","Down"]
["UBE3B","Down"]
["HDDC2","Down"]
["NT5DC3","Down"]
["RALGAPB","Down"]
["COL23A1","Down"]
["ZC3H7A","Down"]
["ALDH16A1","Down"]
["PYROXD2","Down"]
["UBR7","Down"]
["DDX51","Down"]
["AVL9","Down"]
["ZNF280C","Down"]
["RMDN1","Down"]
["INTS14","Down"]
["PAAF1","Down"]
["PITHD1","Down"]
["RNPEP","Down"]
["AAMDC","Down"]
["PSTPIP2","Down"]
["CARS2","Down"]
["GPCPD1","Down"]
["FAM114A2","Down"]
["ECHDC1","Down"]
["ABCF3","Down"]
["TBC1D13","Down"]
["NECAP2","Down"]
["MRPL16","Down"]
["DDX43","Down"]
["DIP2B","Down"]
["BCAP29","Down"]
["TSR3","Down"]
["CRYZL1","Down"]
["IFRD2","Down"]
["R3HDM1","Down"]
["TATDN3","Down"]
["KNOP1","Down"]
["MTHFSD","Down"]
["DPY19L1","Down"]
["GPATCH4","Down"]
["ATPAF1","Down"]
["TMEM164","Down"]
["RPL7L1","Down"]
["RWDD4","Down"]
["FRRS1","Down"]
["RINL","Down"]
["CCDC186","Down"]
["SZRD1","Down"]
["MDP1","Down"]
["SLC35F2","Down"]
["SRBD1","Down"]
["ANKRD52","Down"]
["GSTCD","Down"]
["SLC25A40","Down"]
["FAHD2A","Down"]
["BTF3L4","Down"]
["ZNF512","Down"]
["TANGO6","Down"]
["WDR55","Down"]
["NT5DC2","Down"]
["FBRSL1","Down"]
["DNAJC17","Down"]
["WDR70","Down"]
["FAM120C","Down"]
["THYN1","Down"]
["DMXL1","Down"]
["ZMYM1","Down"]
["RNF214","Down"]
["LRRC40","Down"]
["C1orf112","Down"]

{"sheet":"AS_DEP_KEGG","index":12,"n_rows":302,"n_cols":9,"rows_kept":302}
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["hsa03013","Nucleocytoplasmic transport","26/442","108/8746",{"v":1.4E-11,"d":"1.40E-11"},{"v":4.22e-09,"d":"4.22E-09"},{"v":3.92e-09,"d":"3.92E-09"},"XPO1/IPO13/NUP62/RANBP2/NUP98/NCBP1/NUP160/NUP188/NUP54/NUP93/NUP43/NUP35/THOC2/IPO4/NUP133/NUP205/TNPO1/NMD3/THOC1/IPO9/XPO6/NUP88/NDC1/NUP85/XPO5/AAAS",26]
["hsa04120","Ubiquitin mediated proteolysis","26/442","142/8746",{"v":8.03e-09,"d":"8.03E-09"},{"v":1.21e-06,"d":"1.21E-06"},{"v":1.12e-06,"d":"1.12E-06"},"UBA6/UBR5/UBE4B/HERC2/CDC27/BRCA1/UBA7/CDC16/SKP2/CUL1/CUL4A/UBE4A/HERC1/HERC4/HUWE1/ANAPC1/BIRC6/FANCL/UBA2/CDC23/ANAPC7/ANAPC5/ANAPC4/FBXO4/ANAPC10/UBE3B",26]
["hsa04110","Cell cycle","23/442","157/8746",{"v":3.6e-06,"d":"3.60E-06"},0.00036094,0.000335758,"CHEK1/ORC5/ORC4/CDC45/CHEK2/PPP2R1B/CDC27/PRKDC/CDC16/MAD2L1/SKP2/ATM/ORC2/CUL1/PDS5A/DDX11/ANAPC1/ORC3/CDC23/ANAPC7/ANAPC5/ANAPC4/ANAPC10",23]
["hsa01230","Biosynthesis of amino acids","14/442","75/8746",{"v":1.9e-05,"d":"1.90E-05"},0.001341618,0.001248017,"PHGDH/IDH3B/ASL/PFKM/ASNS/PC/PYCR1/CTH/SHMT1/ALDH18A1/PSPH/PYCR2/SDSL/MTR",14]
["hsa01240","Biosynthesis of cofactors","21/442","153/8746",{"v":2.64e-05,"d":"2.64E-05"},0.001341618,0.001248017,"PMM2/LIAS/NADK/DHFR/UROD/UMPS/MTHFD1/CTPS1/CAD/ADSL/SHMT1/GSS/DHODH/FPGS/COASY/NADSYN1/PPCDC/MMAB/PANK2/GPHN/PNPO",21]
["hsa03440","Homologous recombination","10/442","41/8746",{"v":2.67e-05,"d":"2.67E-05"},0.001341618,0.001248017,"RAD51C/XRCC3/NBN/BRCA1/MRE11/BLM/ATM/TOPBP1/EME1/BARD1",10]
["hsa00270","Cysteine and methionine metabolism","10/442","52/8746",2.28982E-4,0.009846215,0.00915927,"PHGDH/AHCYL1/AMD1/DNMT1/CTH/GSS/KYAT3/SDSL/MTR/DNMT3B",10]
["hsa03460","Fanconi anemia pathway","10/442","54/8746",0.000316379,0.011380278,0.010586305,"RAD51C/BRCA1/MLH1/BLM/CENPS/WDR48/EME1/FANCD2/FANCI/FANCL",10]
["hsa00670","One carbon pool by folate","6/442","20/8746",3.40274E-4,0.011380278,0.010586305,"DHFR/MTHFD1/GART/SHMT1/MTHFR/MTR",6]
["hsa01523","Antifolate resistance","7/442","30/8746",0.000592712,0.017840621,0.016595926,"ABCC4/DHFR/GART/ABCC1/SHMT1/MTHFR/FPGS",7]
["hsa05166","Human T-cell leukemia virus 1 infection","23/442","222/8746",0.000817363,0.022366031,0.020805611,"CHEK1/NRP1/XPO1/CHEK2/ITGB2/FDPS/TCF3/CANX/CDC27/STAT5A/MAPK8/STAT5B/ADCY7/BAX/CDC16/MAD2L1/ATM/ANAPC1/CDC23/ANAPC7/ANAPC5/ANAPC4/ANAPC10",23]
["hsa00562","Inositol phosphate metabolism","10/442","73/8746",3.488751E-3,0.087509511,0.081404196,"SYNJ2/INPPL1/PLCG2/PI4KA/PLCB2/MTM1/MTMR14/MINPP1/MTMR6/PIKFYVE",10]
["hsa04910","Insulin signaling pathway","15/442","137/8746",0.003782841,0.087587308,0.081476566,"INPPL1/FLOT1/PRKAR2A/PTPN1/MTOR/MAPK8/PHKA2/PRKAG1/SOS1/ACACA/FLOT2/PCK2/PHKB/MKNK1/RPS6KB2",15]
["hsa04914","Progesterone-mediated oocyte maturation","12/442","102/8746",0.00517375,0.111235622,0.103474997,"CDC27/MAPK8/RPS6KA3/ADCY7/CDC16/MAD2L1/ANAPC1/CDC23/ANAPC7/ANAPC5/ANAPC4/ANAPC10",12]
["hsa04114","Oocyte meiosis","14/442","131/8746",0.006274041,0.12589909,0.117115433,"PPP2R1B/CDC27/RPS6KA3/ADCY7/CDC16/MAD2L1/CUL1/ITPR2/ANAPC1/CDC23/ANAPC7/ANAPC5/ANAPC4/ANAPC10",14]
["hsa04920","Adipocytokine signaling pathway","9/442","70/8746",0.008309638,0.151412771,0.14084909,"NFKBIE/CD36/ACSL1/MTOR/MAPK8/PRKAG1/PCK2/CAMKK2/ACSL5",9]
["hsa00563","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis","5/442","26/8746",0.008780511,0.151412771,0.14084909,"PIGG/PIGO/PIGT/PIGS/PIGU",5]
["hsa00450","Selenocompound metabolism","4/442","17/8746",0.009054584,0.151412771,0.14084909,"CTH/KYAT3/SCLY/MTR",4]
["hsa00250","Alanine, aspartate and glutamate metabolism","6/442","37/8746",0.00986068,0.156213933,0.145315287,"GLS/ASL/ASNS/CAD/ADSL/NIT2",6]
["hsa00260","Glycine, serine and threonine metabolism","6/442","40/8746",0.014339589,0.215810817,0.200754248,"PHGDH/GCAT/CTH/SHMT1/PSPH/SDSL",6]
["hsa00020","Citrate cycle (TCA cycle)","5/442","30/8746",0.016124843,0.223993596,0.208366136,"IDH3B/PDHA1/PC/ACLY/PCK2",5]
["hsa03018","RNA degradation","9/442","78/8746",0.016371625,0.223993596,0.208366136,"CNOT1/PARN/PFKM/EXOSC10/TENT4B/CNOT9/DHX36/CNOT7/DIS3",9]
["hsa04152","AMPK signaling pathway","12/442","121/8746",0.019012882,0.248820758,0.23146117,"EEF2K/SCD/PFKFB2/PFKM/CD36/PPP2R1B/MTOR/PRKAG1/ACACA/PCK2/CAMKK2/RPS6KB2",12]
["hsa03410","Base excision repair","6/442","44/8746",0.022280746,0.279437692,0.259942039,"LIG1/LIG3/POLG/PARG/TDP1/MUTYH",6]
["hsa04146","Peroxisome","9/442","83/8746",0.023690788,0.28065957,0.26107867,"AGPS/ACOT8/SLC25A17/ECI2/ACSL1/PEX19/PEX6/ACSL5/PEX16",9]
["hsa04070","Phosphatidylinositol signaling system","10/442","97/8746",0.024243019,0.28065957,0.26107867,"SYNJ2/INPPL1/PLCG2/PI4KA/PLCB2/MTM1/ITPR2/MTMR14/MTMR6/PIKFYVE",10]
["hsa00240","Pyrimidine metabolism","7/442","58/8746",0.02604672,0.290372695,0.270114135,"UMPS/CTPS1/DTYMK/CAD/DHODH/NT5C3A/HDDC2",7]
["hsa01524","Platinum drug resistance","8/442","73/8746",0.030253263,0.325222573,0.302532626,"TOP2A/ATP7B/BRCA1/MLH1/CASP9/TOP2B/BAX/ATM",8]
["hsa00520","Amino sugar and nucleotide sugar metabolism","6/442","49/8746",0.035794511,0.37152234,0.345602177,"PMM2/PGM3/HEXA/RENBP/PGM2/NAGK",6]
["hsa00330","Arginine and proline metabolism","6/442","50/8746",0.039012685,0.375271599,0.349089859,"AMD1/PYCR1/ALDH18A1/PYCR2/L3HYPDH/CNDP2",6]
["hsa05170","Human immunodeficiency virus 1 infection","17/442","212/8746",0.03982411,0.375271599,0.349089859,"CHEK1/AP1G2/PLCG2/MTOR/MAPK8/CASP9/PTK2/BAX/ATM/RIPK1/CUL1/CUL4A/ITPR2/IRF3/CGAS/IRAK4/RPS6KB2",17]
["hsa04935","Growth hormone synthesis, secretion and action","11/442","120/8746",0.039895984,0.375271599,0.349089859,"PLCG2/STAT1/STAT5A/MTOR/MAPK8/STAT5B/ADCY7/PLCB2/PTK2/SOS1/ITPR2",11]
["hsa04922","Glucagon signaling pathway","10/442","107/8746",0.043593095,0.397621862,0.369880802,"PFKM/PDHA1/PHKA2/PRKAG1/PLCB2/ACACA/ITPR2/PCK2/PPP4R3B/PHKB",10]
["hsa04931","Insulin resistance","10/442","108/8746",0.04597819,0.407042216,0.378643922,"OGT/OGA/CD36/PTPN1/MTOR/MAPK8/RPS6KA3/PRKAG1/PCK2/RPS6KB2",10]
["hsa04611","Platelet activation","11/442","124/8746",0.048699384,0.4188147,0.38959507,"SNAP23/LYN/ITGA2B/PLCG2/SYK/VASP/ADCY7/PLCB2/ITPR2/PIK3R6/ARHGEF1",11]
["hsa04216","Ferroptosis","5/442","41/8746",0.054114123,0.452454193,0.420887621,"ATG7/ACSL1/GSS/LPCAT3/ACSL5",5]
["hsa04666","Fc gamma R-mediated phagocytosis","9/442","97/8746",0.055952428,0.45518056,0.423423777,"BIN1/INPPL1/LYN/PTPRC/HCK/PLCG2/SYK/VASP/RPS6KB2",9]
["hsa00061","Fatty acid biosynthesis","3/442","18/8746",0.059474893,0.459024172,0.42699923,"ACSL1/ACACA/ACSL5",3]
["hsa04980","Cobalamin transport and metabolism","3/442","18/8746",0.059474893,0.459024172,0.42699923,"MMAB/MTR/MTRR",3]
["hsa04062","Chemokine signaling pathway","15/442","192/8746",0.061702342,0.461301894,0.429118041,"LYN/HCK/PLCG2/ARRB2/STAT1/GRK6/STAT5B/ADCY7/STAT2/PLCB2/PTK2/SOS1/PIK3R6/PREX1/DOCK2",15]
["hsa04012","ErbB signaling pathway","8/442","85/8746",0.064661849,0.461301894,0.429118041,"PLCG2/STAT5A/MTOR/MAPK8/STAT5B/PTK2/SOS1/RPS6KB2",8]
["hsa01200","Carbon metabolism","10/442","115/8746",0.065152389,0.461301894,0.429118041,"PHGDH/IDH3B/PFKM/PDHA1/PC/ME2/SHMT1/PSPH/SDSL/ADPGK",10]
["hsa05161","Hepatitis B","13/442","162/8746",0.066209651,0.461301894,0.429118041,"STAT1/STAT6/STAT5A/MAPK8/STAT5B/STAT2/CASP9/HSPG2/BAX/SOS1/IRF3/CASP10/IRAK4",13]
["hsa03060","Protein export","4/442","31/8746",0.068917965,0.461301894,0.429118041,"SRP72/SRPRA/SRP19/SRP68",4]
["hsa03022","Basal transcription factors","5/442","44/8746",0.069477674,0.461301894,0.429118041,"ERCC2/GTF2H1/GTF2I/TAF2/TAF15",5]
["hsa05223","Non-small cell lung cancer","7/442","72/8746",0.070497964,0.461301894,0.429118041,"PLCG2/STAT5A/STAT5B/CASP9/BAX/SOS1/RASSF5",7]
["hsa05131","Shigellosis","18/442","247/8746",0.075038184,0.475111242,0.441963946,"HCLS1/PLCG2/MTOR/MAPK8/CASP4/PLCB2/PTK2/BAX/ATM/ILK/RIPK1/CUL1/ITPR2/IRF3/CGAS/GLMN/ELMO2/RPS6KB2",18]
["hsa04215","Apoptosis - multiple species","4/442","32/8746",0.075765248,0.475111242,0.441963946,"MAPK8/CASP9/BAX/BIRC6",4]
["hsa04144","Endocytosis","18/442","250/8746",0.082016134,0.503586023,0.468452115,"BIN1/STAMBP/IGF2R/ARRB2/USP8/GRK6/WASHC5/ACAP1/WASHC4/LDLRAP1/ZFYVE27/WASHC2A/ZFYVE16/ARFGAP2/PDCD6IP/SNF8/AGAP2/ARFGEF1",18]
["hsa03320","PPAR signaling pathway","7/442","75/8746",0.083749707,0.503586023,0.468452115,"SCD/ACADM/CD36/ACSL1/ILK/PCK2/ACSL5",7]
["hsa00770","Pantothenate and CoA biosynthesis","3/442","21/8746",0.086831702,0.503586023,0.468452115,"COASY/PPCDC/PANK2",3]
["hsa00620","Pyruvate metabolism","5/442","47/8746",0.08699825,0.503586023,0.468452115,"PDHA1/PC/ME2/ACACA/PCK2",5]
["hsa03420","Nucleotide excision repair","6/442","63/8746",0.097459328,0.553495432,0.514879471,"ERCC2/LIG1/GTF2H1/XPC/ERCC6/CUL4A",6]
["hsa04964","Proximal tubule bicarbonate reclamation","3/442","23/8746",0.107501317,0.595575482,0.554023705,"GLS/ATP1B3/PCK2",3]
["hsa05014","Amyotrophic lateral sclerosis","24/442","364/8746",0.108826085,0.595575482,0.554023705,"CCS/NUP62/MTOR/RANBP2/NUP98/CASP9/BAX/NCBP1/NUP160/NUP188/NUP54/NUP93/NUP43/NUP35/NUP133/NUP205/SPG11/NUP88/ATXN2/NDC1/DERL1/NUP85/WDR41/HDAC6",24]
["hsa05167","Kaposi sarcoma-associated herpesvirus infection","14/442","194/8746",0.113507422,0.598318552,0.556575398,"LYN/HCK/PLCG2/STAT1/MTOR/SYK/MAPK8/STAT2/CASP9/BAX/ITPR2/IRF3/PIK3R6/PREX1",14]
["hsa01250","Biosynthesis of nucleotide sugars","4/442","37/8746",0.114761623,0.598318552,0.556575398,"PMM2/PGM3/PGM2/NAGK",4]
["hsa00970","Aminoacyl-tRNA biosynthesis","6/442","66/8746",0.115290618,0.598318552,0.556575398,"HARS2/AARS2/VARS2/DARS2/TARS2/CARS2",6]
["hsa00010","Glycolysis / Gluconeogenesis","6/442","67/8746",0.121576167,0.609907106,0.567355447,"PFKM/PDHA1/PCK2/PGM2/ADPGK/MINPP1",6]
["hsa05221","Acute myeloid leukemia","6/442","67/8746",0.121576167,0.609907106,0.567355447,"STAT5A/MTOR/STAT5B/RUNX1/SOS1/RPS6KB2",6]
["hsa01232","Nucleotide metabolism","7/442","85/8746",0.137354409,0.668574195,0.621929484,"CTPS1/IMPDH1/DTYMK/ADSL/NT5C3A/GMPR2/HDDC2",7]
["hsa03450","Non-homologous end-joining","2/442","13/8746",0.137712957,0.668574195,0.621929484,"MRE11/PRKDC",2]
["hsa05169","Epstein-Barr virus infection","14/442","202/8746",0.142991697,0.674766823,0.627690068,"NFKBIE/LYN/PLCG2/STAT1/SYK/MAPK8/STAT2/CASP9/BAX/SKP2/RIPK1/IRF3/USP7/IRAK4",14]
["hsa05210","Colorectal cancer","7/442","86/8746",0.143472016,0.674766823,0.627690068,"MLH1/MTOR/MAPK8/CASP9/BAX/SOS1/RPS6KB2",7]
["hsa04722","Neurotrophin signaling pathway","9/442","119/8746",0.147352351,0.682354732,0.634748588,"NFKBIE/NTRK1/PLCG2/MAPK8/RPS6KA3/BAX/SOS1/ZNF274/IRAK4",9]
["hsa00790","Folate biosynthesis","3/442","27/8746",0.153696234,0.700947974,0.652044627,"DHFR/FPGS/GPHN",3]
["hsa01212","Fatty acid metabolism","5/442","57/8746",0.159710869,0.707667619,0.65829546,"SCD/ACADM/ACSL1/ACACA/ACSL5",5]
["hsa05162","Measles","10/442","138/8746",0.159871755,0.707667619,0.65829546,"STAT1/STAT5A/MAPK8/STAT5B/STAT2/CASP9/BAX/IRF3/IRAK4/EIF2AK4",10]
["hsa05213","Endometrial cancer","5/442","58/8746",0.168051162,0.733092749,0.681946743,"MLH1/CASP9/BAX/SOS1/ILK",5]
["hsa00071","Fatty acid degradation","4/442","43/8746",0.170682171,0.733933335,0.682728684,"ECI2/ACADM/ACSL1/ACSL5",4]
["hsa05160","Hepatitis C","11/442","158/8746",0.175506587,0.744049052,0.692138653,"PPP2R1B/STAT1/STAT2/CASP9/PSME3/BAX/SOS1/RIPK1/IRF3/SCARB1/EIF2AK4",11]
["hsa04659","Th17 cell differentiation","8/442","108/8746",0.179189972,0.749113631,0.696849889,"NFKBIE/STAT1/STAT6/STAT5A/MTOR/MAPK8/STAT5B/RUNX1",8]
["hsa05212","Pancreatic cancer","6/442","76/8746",0.18513292,0.753418491,0.70085441,"STAT1/MTOR/MAPK8/CASP9/BAX/RPS6KB2",6]
["hsa04978","Mineral absorption","5/442","60/8746",0.185225808,0.753418491,0.70085441,"ATOX1/ATP2B4/ATP7B/ATP1B3/HEPH",5]
["hsa04140","Autophagy - animal","11/442","165/8746",0.212628845,0.850327118,0.79100197,"ATG7/MTOR/MAPK8/STX17/MTMR14/CAMKK2/VPS11/WDR41/BIRC6/EIF2AK4/RPS6KB2",11]
["hsa03015","mRNA surveillance pathway","7/442","97/8746",0.218556285,0.850327118,0.79100197,"PPP2R1B/PAPOLA/NCBP1/SMG6/DAZAP1/SMG1/HBS1L",7]
["hsa00280","Valine, leucine and isoleucine degradation","4/442","48/8746",0.223088598,0.850327118,0.79100197,"ACADM/IVD/MCCC2/ACAD8",4]
["hsa04670","Leukocyte transendothelial migration","8/442","115/8746",0.22525457,0.850327118,0.79100197,"ITGB2/ITGA4/PECAM1/PLCG2/VASP/PTK2/RHOH/RASSF5",8]
["hsa01522","Endocrine resistance","7/442","98/8746",0.226000563,0.850327118,0.79100197,"MTOR/MAPK8/ADCY7/PTK2/BAX/SOS1/RPS6KB2",7]
["hsa04925","Aldosterone synthesis and secretion","7/442","98/8746",0.226000563,0.850327118,0.79100197,"ATP2B4/ADCY7/ATP1B3/PLCB2/ITPR2/DAGLB/SCARB1",7]
["hsa00511","Other glycan degradation","2/442","18/8746",0.23004459,0.854857056,0.795215866,"MANBA/HEXA",2]
["hsa04933","AGE-RAGE signaling pathway in diabetic complications","7/442","100/8746",0.241144935,0.868044834,0.807483567,"PLCG2/STAT1/STAT5A/MAPK8/STAT5B/PLCB2/BAX",7]
["hsa03083","Polycomb repressive complex","6/442","83/8746",0.241805339,0.868044834,0.807483567,"OGT/EED/EZH2/USP7/L3MBTL2/FBRSL1",6]
["hsa00051","Fructose and mannose metabolism","3/442","34/8746",0.245402997,0.868044834,0.807483567,"PMM2/PFKFB2/PFKM",3]
["hsa00785","Lipoic acid metabolism","2/442","19/8746",0.249099985,0.868044834,0.807483567,"LIAS/PDHA1",2]
["hsa04662","B cell receptor signaling pathway","6/442","84/8746",0.250300522,0.868044834,0.807483567,"NFKBIE/INPPL1/LYN/PLCG2/SYK/SOS1",6]
["hsa05135","Yersinia infection","9/442","137/8746",0.256160581,0.868044834,0.807483567,"ITGA4/MAPK8/RPS6KA3/PTK2/IRF3/ARHGEF1/ELMO2/IRAK4/BAIAP2",9]
["hsa04664","Fc epsilon RI signaling pathway","5/442","68/8746",0.259356645,0.868044834,0.807483567,"LYN/PLCG2/SYK/MAPK8/SOS1",5]
["hsa04150","mTOR signaling pathway","10/442","156/8746",0.264148315,0.868044834,0.807483567,"MTOR/RPS6KA3/SOS1/NPRL3/SKP2/GRB10/RICTOR/NPRL2/RPS6KB2/LAMTOR2",10]
["hsa05132","Salmonella infection","15/442","247/8746",0.267171756,0.868044834,0.807483567,"PTPRC/MAPK8/CASP4/BAX/DYNC1I2/RIPK1/DYNC1H1/RHOH/FBXO22/CYFIP2/ELMO2/EXOC2/VPS11/IRAK4/FHOD1",15]
["hsa04071","Sphingolipid signaling pathway","8/442","121/8746",0.267775597,0.868044834,0.807483567,"SPTLC2/PPP2R1B/ABCC1/MAPK8/PLCB2/BAX/ASAH1/NSMAF",8]
["hsa04919","Thyroid hormone signaling pathway","8/442","121/8746",0.267775597,0.868044834,0.807483567,"PFKFB2/PFKM/PLCG2/STAT1/MTOR/ATP1B3/CASP9/PLCB2",8]
["hsa00100","Steroid biosynthesis","2/442","20/8746",0.268199899,0.868044834,0.807483567,"LSS/LBR",2]
["hsa04625","C-type lectin receptor signaling pathway","7/442","104/8746",0.272341831,0.869815031,0.809130261,"PLCG2/STAT1/SYK/MAPK8/STAT2/ITPR2/CYLD",7]
["hsa04917","Prolactin signaling pathway","5/442","70/8746",0.278922191,0.869815031,0.809130261,"STAT1/STAT5A/MAPK8/STAT5B/SOS1",5]
["hsa05230","Central carbon metabolism in cancer","5/442","70/8746",0.278922191,0.869815031,0.809130261,"GLS/NTRK1/PFKM/PDHA1/MTOR",5]
["hsa04064","NF-kappa B signaling pathway","7/442","105/8746",0.280305841,0.869815031,0.809130261,"LYN/PLCG2/SYK/ATM/RIPK1/CYLD/IRAK4",7]
["hsa04936","Alcoholic liver disease","9/442","142/8746",0.290270309,0.89154452,0.82934374,"SCD/ACADM/MAPK8/PRKAG1/ACACA/RIPK1/IRF3/CAMKK2/IRAK4",9]
["hsa04211","Longevity regulating pathway","6/442","89/8746",0.293907626,0.893597934,0.831253892,"MTOR/ADCY7/PRKAG1/BAX/CAMKK2/RPS6KB2",6]
["hsa04622","RIG-I-like receptor signaling pathway","5/442","72/8746",0.298770078,0.899297935,0.836556218,"MAPK8/RIPK1/IRF3/CASP10/CYLD",5]
["hsa04066","HIF-1 signaling pathway","7/442","108/8746",0.304525561,0.903963003,0.840895816,"PFKM/PDHA1/PLCG2/MTOR/MKNK1/EGLN1/RPS6KB2",7]
["hsa00220","Arginine biosynthesis","2/442","22/8746",0.306326333,0.903963003,0.840895816,"GLS/ASL",2]
["hsa00230","Purine metabolism","8/442","128/8746",0.319967971,0.919192671,0.85506295,"IMPDH1/GART/ADSL/ADCY7/PRUNE1/PGM2/GMPR2/HDDC2",8]
["hsa04658","Th1 and Th2 cell differentiation","6/442","92/8746",0.320772208,0.919192671,0.85506295,"NFKBIE/STAT1/STAT6/STAT5A/MAPK8/STAT5B",6]
["hsa03430","Mismatch repair","2/442","23/8746",0.325262049,0.919192671,0.85506295,"LIG1/MLH1",2]
["hsa04115","p53 signaling pathway","5/442","75/8746",0.32893163,0.919192671,0.85506295,"CHEK1/CHEK2/CASP9/BAX/ATM",5]
["hsa04918","Thyroid hormone synthesis","5/442","75/8746",0.32893163,0.919192671,0.85506295,"CANX/ADCY7/ATP1B3/PLCB2/ITPR2",5]
["hsa04970","Salivary secretion","6/442","93/8746",0.329809995,0.919192671,0.85506295,"ATP2B4/ADCY7/ATP1B3/SLC12A2/PLCB2/ITPR2",6]
["hsa05203","Viral carcinogenesis","12/442","204/8746",0.335729243,0.920621394,0.856391995,"CHEK1/LYN/GTF2H1/STAT5A/SYK/STAT5B/BAX/SKP2/IRF3/HDAC7/USP7/HDAC6",12]
["hsa05220","Chronic myeloid leukemia","5/442","76/8746",0.339058299,0.920621394,0.856391995,"STAT5A/STAT5B/RUNX1/BAX/SOS1",5]
["hsa04621","NOD-like receptor signaling pathway","11/442","186/8746",0.339498255,0.920621394,0.856391995,"STAT1/MAPK8/CASP4/STAT2/PLCB2/RIPK1/ITPR2/IRF3/DHX33/IRAK4/CARD8",11]
["hsa04068","FoxO signaling pathway","8/442","131/8746",0.342923776,0.921607647,0.857309439,"MAPK8/PRKAG1/SOS1/SKP2/ATM/PCK2/USP7/AGAP2",8]
["hsa05163","Human cytomegalovirus infection","13/442","225/8746",0.349575206,0.925785522,0.861195834,"MTOR/ADCY7/CASP9/PLCB2/PTK2/BAX/SOS1/RIPK1/ITPR2/IRF3/CGAS/ARHGEF1/RPS6KB2",13]
["hsa04142","Lysosome","8/442","132/8746",0.350629733,0.925785522,0.861195834,"AP4M1/MANBA/AP1G2/HEXA/IGF2R/ASAH1/AP3S1/DMXL1",8]
["hsa04141","Protein processing in endoplasmic reticulum","10/442","170/8746",0.356879614,0.934093599,0.868924278,"UBE4B/CANX/MAPK8/ATXN3/BAX/CUL1/DNAJC10/NPLOC4/NGLY1/DERL1",10]
["hsa04730","Long-term depression","4/442","60/8746",0.360116298,0.934439705,0.869246238,"LYN/PPP2R1B/PLCB2/ITPR2",4]
["hsa01521","EGFR tyrosine kinase inhibitor resistance","5/442","79/8746",0.369551986,0.941565521,0.875874904,"PLCG2/MTOR/BAX/SOS1/RPS6KB2",5]
["hsa04213","Longevity regulating pathway - multiple species","4/442","61/8746",0.371770436,0.941565521,0.875874904,"MTOR/ADCY7/PRKAG1/RPS6KB2",4]
["hsa04210","Apoptosis","8/442","135/8746",0.373863884,0.941565521,0.875874904,"NTRK1/MAPK8/CASP9/BAX/ATM/RIPK1/ITPR2/CASP10",8]
["hsa04750","Inflammatory mediator regulation of TRP channels","6/442","98/8746",0.375374959,0.941565521,0.875874904,"NTRK1/PLCG2/MAPK8/ADCY7/PLCB2/ITPR2",6]
["hsa04977","Vitamin digestion and absorption","2/442","26/8746",0.381108397,0.948046508,0.881903728,"ABCC1/SCARB1",2]
["hsa03250","Viral life cycle - HIV-1","4/442","63/8746",0.395022956,0.952993676,0.886505745,"XPO1/RANBP2/NELFCD/PDCD6IP",4]
["hsa05171","Coronavirus disease - COVID-19","13/442","233/8746",0.397199843,0.952993676,0.886505745,"NRP1/PLCG2/RPL10/RPL13A/STAT1/SYK/MAPK8/STAT2/RPL27/RPL23/IRF3/CGAS/IRAK4",13]
["hsa02010","ABC transporters","3/442","45/8746",0.399123139,0.952993676,0.886505745,"ABCC4/ABCB7/ABCC1",3]
["hsa00920","Sulfur metabolism","1/442","10/8746",0.404804488,0.952993676,0.886505745,"SELENBP1",1]
["hsa04623","Cytosolic DNA-sensing pathway","5/442","83/8746",0.410212132,0.952993676,0.886505745,"POLR3A/RIPK1/IRF3/CGAS/POLR3F",5]
["hsa04972","Pancreatic secretion","6/442","102/8746",0.411964945,0.952993676,0.886505745,"ATP2B4/ADCY7/ATP1B3/SLC12A2/PLCB2/ITPR2",6]
["hsa04217","Necroptosis","9/442","159/8746",0.412475436,0.952993676,0.886505745,"STAT1/STAT6/STAT5A/MAPK8/STAT5B/STAT2/BAX/RIPK1/CYLD",9]
["hsa00860","Porphyrin metabolism","3/442","46/8746",0.41290301,0.952993676,0.886505745,"UROD/MMAB/HEPH",3]
["hsa03050","Proteasome","3/442","46/8746",0.41290301,0.952993676,0.886505745,"PSME3/PSME4/PSMF1",3]
["hsa05130","Pathogenic Escherichia coli infection","11/442","198/8746",0.41768405,0.952993676,0.886505745,"MYO1G/HCLS1/MAPK8/CASP4/CASP9/BAX/RIPK1/ARHGEF1/CYFIP2/IRAK4/BAIAP2",11]
["hsa04927","Cortisol synthesis and secretion","4/442","65/8746",0.418138092,0.952993676,0.886505745,"ADCY7/PLCB2/ITPR2/SCARB1",4]
["hsa04137","Mitophagy - animal","6/442","103/8746",0.421090229,0.952993676,0.886505745,"MTX2/USP8/MAPK8/HUWE1/RHOT2/TBC1D17",6]
["hsa05017","Spinocerebellar ataxia","8/442","143/8746",0.436117983,0.967335885,0.899847334,"MTOR/MAPK8/ATXN3/PLCB2/ITPR2/PUM2/ATXN2/ATXN10",8]
["hsa04510","Focal adhesion","11/442","202/8746",0.443922856,0.967335885,0.899847334,"FLNB/ITGA2B/ITGA4/ITGB7/MAPK8/VASP/PTK2/SOS1/ILK/PARVG/PARVB",11]
["hsa05205","Proteoglycans in cancer","11/442","203/8746",0.450470719,0.967335885,0.899847334,"HCLS1/ANK1/PLCG2/MTOR/HSPG2/PTK2/SOS1/ITPR2/PDCD4/ARHGEF1/RPS6KB2",11]
["hsa04620","Toll-like receptor signaling pathway","6/442","108/8746",0.46635536,0.967335885,0.899847334,"STAT1/MAPK8/STAT2/RIPK1/IRF3/IRAK4",6]
["hsa05144","Malaria","3/442","50/8746",0.466896381,0.967335885,0.899847334,"ITGB2/PECAM1/CD36",3]
["hsa00030","Pentose phosphate pathway","2/442","31/8746",0.469341591,0.967335885,0.899847334,"PFKM/PGM2",2]
["hsa04512","ECM-receptor interaction","5/442","89/8746",0.470372086,0.967335885,0.899847334,"ITGA2B/ITGA4/CD36/ITGB7/HSPG2",5]
["hsa03008","Ribosome biogenesis in eukaryotes","9/442","167/8746",0.470689091,0.967335885,0.899847334,"XPO1/NVL/NMD3/GNL3/HEATR1/MDN1/UTP6/REXO2/TBL3",9]
["hsa04072","Phospholipase D signaling pathway","8/442","148/8746",0.474727854,0.967335885,0.899847334,"PLCG2/MTOR/SYK/ADCY7/PLCB2/SOS1/PIK3R6/AGPAT5",8]
["hsa04979","Cholesterol metabolism","3/442","51/8746",0.480057303,0.967335885,0.899847334,"CD36/LDLRAP1/SCARB1",3]
["hsa00052","Galactose metabolism","2/442","32/8746",0.48608414,0.967335885,0.899847334,"PFKM/PGM2",2]
["hsa00640","Propanoate metabolism","2/442","32/8746",0.48608414,0.967335885,0.899847334,"ACACA/ECHDC1",2]
["hsa04136","Autophagy - other","2/442","32/8746",0.48608414,0.967335885,0.899847334,"ATG7/MTOR",2]
["hsa05164","Influenza A","9/442","171/8746",0.499401186,0.967335885,0.899847334,"XPO1/FDPS/STAT1/STAT2/NUP98/CASP9/BAX/IRF3/IRAK4",9]
["hsa05222","Small cell lung cancer","5/442","92/8746",0.499749342,0.967335885,0.899847334,"ITGA2B/CASP9/PTK2/BAX/SKP2",5]
["hsa04613","Neutrophil extracellular trap formation","10/442","191/8746",0.500989583,0.967335885,0.899847334,"ATG7/ITGB2/ITGA2B/PLCG2/MTOR/SYK/CASP4/PLCB2/HDAC7/HDAC6",10]
["hsa01210","2-Oxocarboxylic acid metabolism","2/442","33/8746",0.502494111,0.967335885,0.899847334,"IDH3B/PDHA1",2]
["hsa04130","SNARE interactions in vesicular transport","2/442","33/8746",0.502494111,0.967335885,0.899847334,"SNAP23/STX17",2]
["hsa04145","Phagosome","8/442","152/8746",0.505171352,0.967335885,0.899847334,"ITGB2/CD36/CANX/CORO1A/DYNC1I2/DYNC1H1/SCARB1/PIKFYVE",8]
["hsa04961","Endocrine and other factor-regulated calcium reabsorption","3/442","53/8746",0.50590754,0.967335885,0.899847334,"ATP2B4/ATP1B3/PLCB2",3]
["hsa04912","GnRH signaling pathway","5/442","93/8746",0.509404986,0.967335885,0.899847334,"MAPK8/ADCY7/PLCB2/SOS1/ITPR2",5]
["hsa03020","RNA polymerase","2/442","34/8746",0.518562305,0.967335885,0.899847334,"POLR3A/POLR3F",2]
["hsa04710","Circadian rhythm","2/442","34/8746",0.518562305,0.967335885,0.899847334,"PRKAG1/CUL1",2]
["hsa00600","Sphingolipid metabolism","3/442","54/8746",0.518580901,0.967335885,0.899847334,"SPTLC2/HEXA/ASAH1",3]
["hsa04928","Parathyroid hormone synthesis, secretion and action","6/442","114/8746",0.519341327,0.967335885,0.899847334,"ARRB2/ADCY7/PLCB2/ITPR2/ARHGEF1/WNK1",6]
["hsa04380","Osteoclast differentiation","7/442","135/8746",0.527728408,0.967335885,0.899847334,"PLCG2/STAT1/SYK/MAPK8/STAT2/ITPR2/CYLD",7]
["hsa05214","Glioma","4/442","75/8746",0.529407322,0.967335885,0.899847334,"PLCG2/MTOR/BAX/SOS1",4]
["hsa04218","Cellular senescence","8/442","156/8746",0.535051911,0.967335885,0.899847334,"CHEK1/NBN/CHEK2/MTOR/MRE11/ATM/ITPR2/RASSF5",8]
["hsa04971","Gastric acid secretion","4/442","76/8746",0.539982267,0.967335885,0.899847334,"ADCY7/ATP1B3/PLCB2/ITPR2",4]
["hsa05133","Pertussis","4/442","76/8746",0.539982267,0.967335885,0.899847334,"ITGB2/MAPK8/IRF3/IRAK4",4]
["hsa00604","Glycosphingolipid biosynthesis - ganglio series","1/442","15/8746",0.540918096,0.967335885,0.899847334,"HEXA",1]
["hsa05134","Legionellosis","3/442","56/8746",0.543389621,0.967335885,0.899847334,"ITGB2/CASP9/HBS1L",3]
["hsa03030","DNA replication","2/442","36/8746",0.549645283,0.967335885,0.899847334,"POLA1/LIG1",2]
["hsa05100","Bacterial invasion of epithelial cells","4/442","77/8746",0.550435609,0.967335885,0.899847334,"HCLS1/PTK2/ILK/ELMO2",4]
["hsa05140","Leishmaniasis","4/442","77/8746",0.550435609,0.967335885,0.899847334,"ITGB2/ITGA4/STAT1/IRAK4",4]
["hsa05231","Choline metabolism in cancer","5/442","98/8746",0.556472255,0.967335885,0.899847334,"MTOR/MAPK8/SOS1/RPS6KB2/GPCPD1",5]
["hsa04371","Apelin signaling pathway","7/442","139/8746",0.559110326,0.967335885,0.899847334,"MTOR/ADCY7/PRKAG1/PLCB2/ITPR2/PIK3R6/RPS6KB2",7]
["hsa05152","Tuberculosis","9/442","180/8746",0.562197859,0.967335885,0.899847334,"ITGB2/CORO1A/STAT1/SYK/MAPK8/CASP9/BAX/CASP10/IRAK4",9]
["hsa00603","Glycosphingolipid biosynthesis - globo and isoglobo series","1/442","16/8746",0.564158756,0.967335885,0.899847334,"HEXA",1]
["hsa00760","Nicotinate and nicotinamide metabolism","2/442","37/8746",0.564649925,0.967335885,0.899847334,"NADK/NADSYN1",2]
["hsa05216","Thyroid cancer","2/442","37/8746",0.564649925,0.967335885,0.899847334,"NTRK1/BAX",2]
["hsa00564","Glycerophospholipid metabolism","5/442","99/8746",0.565618325,0.967335885,0.899847334,"PTDSS1/LPCAT3/PCYT2/AGPAT5/GPCPD1",5]
["hsa04640","Hematopoietic cell lineage","5/442","99/8746",0.565618325,0.967335885,0.899847334,"ITGA2B/ITGA4/ANPEP/CD36/CD33",5]
["hsa04370","VEGF signaling pathway","3/442","59/8746",0.579174273,0.984923481,0.916207889,"PLCG2/CASP9/PTK2",3]
["hsa00120","Primary bile acid biosynthesis","1/442","17/8746",0.586225403,0.991313744,0.92215232,"ACOT8",1]
["hsa04022","cGMP-PKG signaling pathway","8/442","166/8746",0.606432505,1,0.930232558,"ATP2B4/VASP/ADCY7/ATP1B3/GTF2I/PLCB2/ITPR2/PIK3R6",8]
["hsa00531","Glycosaminoglycan degradation","1/442","19/8746",0.627070395,1,0.930232558,"HEXA",1]
["hsa03010","Ribosome","8/442","170/8746",0.633376148,1,0.930232558,"RPL10/RPL13A/RPL27/RPL23/MRPL22/MRPS15/MRPL2/MRPL16",8]
["hsa04929","GnRH secretion","3/442","64/8746",0.634744172,1,0.930232558,"ARRB2/PLCB2/ITPR2",3]
["hsa04350","TGF-beta signaling pathway","5/442","108/8746",0.643289179,1,0.930232558,"PPP2R1B/CUL1/ZFYVE16/RPS6KB2/TFR2",5]
["hsa04814","Motor proteins","9/442","193/8746",0.646462545,1,0.930232558,"MYO1G/KIF2A/KIF1B/DYNC1I2/DYNC1H1/KIF14/MYO19/KIF16B/KIF2C",9]
["hsa05202","Transcriptional misregulation in cancer","9/442","193/8746",0.646462545,1,0.930232558,"NTRK1/HPGD/TCF3/ITGB7/RUNX1/PTK2/BAX/ATM/TAF15",9]
["hsa04975","Fat digestion and absorption","2/442","43/8746",0.647043055,1,0.930232558,"CD36/SCARB1",2]
["hsa05417","Lipid and atherosclerosis","10/442","215/8746",0.652690665,1,0.930232558,"LYN/CD36/MAPK8/CASP9/PLCB2/PTK2/BAX/IRF3/ARHGEF1/IRAK4",10]
["hsa04540","Gap junction","4/442","88/8746",0.656424348,1,0.930232558,"ADCY7/PLCB2/SOS1/ITPR2",4]
["hsa04962","Vasopressin-regulated water reabsorption","2/442","44/8746",0.659509103,1,0.930232558,"DYNC1I2/DYNC1H1",2]
["hsa04727","GABAergic synapse","4/442","89/8746",0.665179749,1,0.930232558,"GLS/ADCY7/SLC38A5/GPHN",4]
["hsa04976","Bile secretion","4/442","89/8746",0.665179749,1,0.930232558,"ABCC4/ADCY7/ATP1B3/SCARB1",4]
["hsa05235","PD-L1 expression and PD-1 checkpoint pathway in cancer","4/442","89/8746",0.665179749,1,0.930232558,"NFKBIE/STAT1/MTOR/RPS6KB2",4]
["hsa04720","Long-term potentiation","3/442","67/8746",0.665544104,1,0.930232558,"RPS6KA3/PLCB2/ITPR2",3]
["hsa05145","Toxoplasmosis","5/442","111/8746",0.667166787,1,0.930232558,"STAT1/MAPK8/CASP9/PIK3R6/IRAK4",5]
["hsa04921","Oxytocin signaling pathway","7/442","154/8746",0.667368328,1,0.930232558,"EEF2K/ADCY7/PRKAG1/PLCB2/ITPR2/PIK3R6/CAMKK2",7]
["hsa04148","Efferocytosis","7/442","156/8746",0.680503671,1,0.930232558,"PECAM1/CD36/PTK2/ATP11C/VPS11/TMEM30A/ATP8A1",7]
["hsa00340","Histidine metabolism","1/442","22/8746",0.680918588,1,0.930232558,"CNDP2",1]
["hsa04930","Type II diabetes mellitus","2/442","46/8746",0.683379945,1,0.930232558,"MTOR/MAPK8",2]
["hsa05120","Epithelial cell signaling in Helicobacter pylori infection","3/442","70/8746",0.694412821,1,0.930232558,"LYN/PLCG2/MAPK8",3]
["hsa00514","Other types of O-glycan biosynthesis","2/442","47/8746",0.694793173,1,0.930232558,"OGT/GALNT7",2]
["hsa04973","Carbohydrate digestion and absorption","2/442","47/8746",0.694793173,1,0.930232558,"ATP1B3/PLCB2",2]
["hsa00900","Terpenoid backbone biosynthesis","1/442","23/8746",0.697084794,1,0.930232558,"FDPS",1]
["hsa04614","Renin-angiotensin system","1/442","23/8746",0.697084794,1,0.930232558,"ANPEP",1]
["hsa04672","Intestinal immune network for IgA production","2/442","49/8746",0.716599765,1,0.930232558,"ITGA4/ITGB7",2]
["hsa05110","Vibrio cholerae infection","2/442","50/8746",0.727004072,1,0.930232558,"PLCG2/SLC12A2",2]
["hsa04810","Regulation of actin cytoskeleton","10/442","229/8746",0.728074887,1,0.930232558,"ITGB2/ITGA2B/ITGA4/ITGB7/PTK2/SOS1/ARHGEF1/CYFIP2/BAIAP2/PIKFYVE",10]
["hsa04913","Ovarian steroidogenesis","2/442","51/8746",0.737083532,1,0.930232558,"ADCY7/SCARB1",2]
["hsa04660","T cell receptor signaling pathway","5/442","121/8746",0.738978765,1,0.930232558,"NFKBIE/PTPRC/PPP2R1B/MAPK8/SOS1",5]
["hsa04630","JAK-STAT signaling pathway","7/442","166/8746",0.741145552,1,0.930232558,"STAT1/STAT6/STAT5A/MTOR/STAT5B/STAT2/SOS1",7]
["hsa05410","Hypertrophic cardiomyopathy","4/442","99/8746",0.744273304,1,0.930232558,"ITGA2B/ITGA4/ITGB7/PRKAG1",4]
["hsa00062","Fatty acid elongation","1/442","27/8746",0.753978663,1,0.930232558,"THEM4",1]
["hsa01040","Biosynthesis of unsaturated fatty acids","1/442","27/8746",0.753978663,1,0.930232558,"SCD",1]
["hsa05142","Chagas disease","4/442","102/8746",0.765023546,1,0.930232558,"PPP2R1B/MAPK8/PLCB2/IRAK4",4]
["hsa04340","Hedgehog signaling pathway","2/442","56/8746",0.782830779,1,0.930232558,"ARRB2/CUL1",2]
["hsa05414","Dilated cardiomyopathy","4/442","105/8746",0.784440421,1,0.930232558,"ITGA2B/ITGA4/ITGB7/ADCY7",4]
["hsa04926","Relaxin signaling pathway","5/442","129/8746",0.787760649,1,0.930232558,"ARRB2/MAPK8/ADCY7/PLCB2/SOS1",5]
["hsa00630","Glyoxylate and dicarboxylate metabolism","1/442","30/8746",0.789533187,1,0.930232558,"SHMT1",1]
["hsa00480","Glutathione metabolism","2/442","57/8746",0.791096872,1,0.930232558,"ANPEP/GSS",2]
["hsa05206","MicroRNAs in cancer","13/442","310/8746",0.795431595,1,0.930232558,"GLS/PLCG2/DNMT1/SLC7A1/ABCC1/BRCA1/MTOR/SOS1/ATM/EZH2/PDCD4/DNMT3B/DICER1",13]
["hsa04261","Adrenergic signaling in cardiomyocytes","6/442","154/8746",0.797601396,1,0.930232558,"ATP2B4/PPP2R1B/ADCY7/ATP1B3/PLCB2/PIK3R6",6]
["hsa00410","beta-Alanine metabolism","1/442","31/8746",0.80020624,1,0.930232558,"CNDP2",1]
["hsa04934","Cushing syndrome","6/442","155/8746",0.80257956,1,0.930232558,"USP8/ADCY7/PLCB2/ITPR2/SCARB1/ASH2L",6]
["hsa04650","Natural killer cell mediated cytotoxicity","5/442","132/8746",0.80412483,1,0.930232558,"ITGB2/PLCG2/SYK/SH3BP2/SOS1",5]
["hsa04728","Dopaminergic synapse","5/442","132/8746",0.80412483,1,0.930232558,"PPP2R1B/ARRB2/MAPK8/PLCB2/ITPR2",5]
["hsa04151","PI3K-Akt signaling pathway","15/442","359/8746",0.813395465,1,0.930232558,"NTRK1/ITGA2B/ITGA4/ITGB7/PPP2R1B/BRCA1/MTOR/SYK/CASP9/PTK2/SOS1/PCK2/THEM4/PIK3R6/RPS6KB2",15]
["hsa04911","Insulin secretion","3/442","86/8746",0.81715408,1,0.930232558,"ADCY7/ATP1B3/PLCB2",3]
["hsa05412","Arrhythmogenic right ventricular cardiomyopathy","3/442","86/8746",0.81715408,1,0.930232558,"ITGA2B/ITGA4/ITGB7",3]
["hsa04820","Cytoskeleton in muscle cells","9/442","229/8746",0.825414946,1,0.930232558,"FMNL1/ITGA2B/ITGA4/ITGB7/ATP1B3/HSPG2/LBR/INF2/PDLIM7",9]
["hsa04725","Cholinergic synapse","4/442","113/8746",0.830005828,1,0.930232558,"ADCY7/PLCB2/ITPR2/PIK3R6",4]
["hsa00310","Lysine degradation","2/442","63/8746",0.835089412,1,0.930232558,"PLOD1/EZH2",2]
["hsa00561","Glycerolipid metabolism","2/442","63/8746",0.835089412,1,0.930232558,"ABHD16A/AGPAT5",2]
["hsa04668","TNF signaling pathway","4/442","114/8746",0.835097736,1,0.930232558,"MAPK8/RIPK1/CASP10/CYLD",4]
["hsa04714","Thermogenesis","9/442","232/8746",0.836515182,1,0.930232558,"ACSL1/MTOR/RPS6KA3/ADCY7/PRKAG1/SOS1/NDUFAF7/RPS6KB2/ACSL5",9]
["hsa04724","Glutamatergic synapse","4/442","115/8746",0.84006191,1,0.930232558,"GLS/ADCY7/PLCB2/ITPR2",4]
["hsa05032","Morphine addiction","3/442","91/8746",0.845761369,1,0.930232558,"ARRB2/GRK6/ADCY7",3]
["hsa00350","Tyrosine metabolism","1/442","36/8746",0.845995486,1,0.930232558,"FAH",1]
["hsa00500","Starch and sucrose metabolism","1/442","36/8746",0.845995486,1,0.930232558,"PGM2",1]
["hsa00512","Mucin type O-glycan biosynthesis","1/442","36/8746",0.845995486,1,0.930232558,"GALNT7",1]
["hsa05207","Chemical carcinogenesis - receptor activation","8/442","212/8746",0.847397208,1,0.930232558,"ARRB2/STAT5A/MTOR/STAT5B/RPS6KA3/ADCY7/SOS1/RPS6KB2",8]
["hsa05321","Inflammatory bowel disease","2/442","65/8746",0.847784766,1,0.930232558,"STAT1/STAT6",2]
["hsa03082","ATP-dependent chromatin remodeling","4/442","117/8746",0.84961523,1,0.930232558,"YEATS4/PBRM1/BRD8/BAZ2A",4]
["hsa04014","Ras signaling pathway","9/442","236/8746",0.850454226,1,0.930232558,"NTRK1/PLCG2/MAPK8/SOS1/RASAL3/RASGRP4/RASSF5/EXOC2/RALGAPB",9]
["hsa04960","Aldosterone-regulated sodium reabsorption","1/442","37/8746",0.85381064,1,0.930232558,"ATP1B3",1]
["hsa05143","African trypanosomiasis","1/442","37/8746",0.85381064,1,0.930232558,"PLCB2",1]
["hsa04520","Adherens junction","3/442","93/8746",0.85607165,1,0.930232558,"KRIT1/PTPN1/BAIAP2",3]
["hsa05225","Hepatocellular carcinoma","6/442","168/8746",0.858952278,1,0.930232558,"PLCG2/MTOR/BAX/SOS1/PBRM1/RPS6KB2",6]
["hsa04657","IL-17 signaling pathway","3/442","94/8746",0.860997588,1,0.930232558,"MAPK8/USP25/ANAPC5",3]
["hsa05340","Primary immunodeficiency","1/442","38/8746",0.861230057,1,0.930232558,"PTPRC",1]
["hsa05165","Human papillomavirus infection","13/442","331/8746",0.862224242,1,0.930232558,"ITGA2B/ITGA4/ITGB7/PPP2R1B/STAT1/MTOR/STAT2/PTK2/BAX/SOS1/ATM/IRF3/RPS6KB2",13]
["hsa04530","Tight junction","6/442","170/8746",0.86632679,1,0.930232558,"HCLS1/PPP2R1B/MAPK8/VASP/PRKAG1/RUNX1",6]
["hsa04924","Renin secretion","2/442","69/8746",0.87054621,1,0.930232558,"PLCB2/ITPR2",2]
["hsa05211","Renal cell carcinoma","2/442","69/8746",0.87054621,1,0.930232558,"SOS1/EGLN1",2]
["hsa05416","Viral myocarditis","2/442","69/8746",0.87054621,1,0.930232558,"ITGB2/CASP9",2]
["hsa05224","Breast cancer","5/442","147/8746",0.871442424,1,0.930232558,"BRCA1/MTOR/BAX/SOS1/RPS6KB2",5]
["hsa05215","Prostate cancer","3/442","97/8746",0.874899157,1,0.930232558,"MTOR/CASP9/SOS1",3]
["hsa04723","Retrograde endocannabinoid signaling","5/442","148/8746",0.875139801,1,0.930232558,"MAPK8/ADCY7/PLCB2/ITPR2/DAGLB",5]
["hsa05226","Gastric cancer","5/442","149/8746",0.878746741,1,0.930232558,"MLH1/MTOR/BAX/SOS1/RPS6KB2",5]
["hsa00380","Tryptophan metabolism","1/442","42/8746",0.887335439,1,0.930232558,"KYAT3",1]
["hsa00513","Various types of N-glycan biosynthesis","1/442","42/8746",0.887335439,1,0.930232558,"HEXA",1]
["hsa05146","Amoebiasis","3/442","102/8746",0.895347955,1,0.930232558,"ITGB2/PLCB2/PTK2",3]
["hsa04514","Cell adhesion molecules","5/442","157/8746",0.904531176,1,0.930232558,"ITGB2/PTPRC/ITGA4/PECAM1/ITGB7",5]
["hsa04612","Antigen processing and presentation","2/442","78/8746",0.910771226,1,0.930232558,"CANX/PSME3",2]
["hsa04015","Rap1 signaling pathway","7/442","210/8746",0.912401418,1,0.930232558,"KRIT1/ITGB2/ITGA2B/VASP/ADCY7/PLCB2/RASSF5",7]
["hsa04270","Vascular smooth muscle contraction","4/442","134/8746",0.912912259,1,0.930232558,"ADCY7/PLCB2/ITPR2/ARHGEF1",4]
["hsa00983","Drug metabolism - other enzymes","2/442","80/8746",0.917959916,1,0.930232558,"UMPS/IMPDH1",2]
["hsa04915","Estrogen signaling pathway","4/442","137/8746",0.921222498,1,0.930232558,"ADCY7/PLCB2/SOS1/ITPR2",4]
["hsa00565","Ether lipid metabolism","1/442","50/8746",0.925759137,1,0.930232558,"AGPS",1]
["hsa05418","Fluid shear stress and atherosclerosis","4/442","139/8746",0.926361178,1,0.930232558,"ITGA2B/PECAM1/MAPK8/PTK2",4]
["hsa04010","MAPK signaling pathway","10/442","299/8746",0.941585109,1,0.930232558,"NTRK1/ARRB2/MAPK8/RPS6KA3/SOS1/RASGRP4/ECSIT/MKNK1/TAOK3/IRAK4",10]
["hsa04020","Calcium signaling pathway","8/442","253/8746",0.94668425,1,0.930232558,"NTRK1/PLCG2/ATP2B4/PHKA2/ADCY7/PLCB2/ITPR2/PHKB",8]
["hsa04923","Regulation of lipolysis in adipocytes","1/442","58/8746",0.951097895,1,0.930232558,"ADCY7",1]
["hsa00590","Arachidonic acid metabolism","1/442","61/8746",0.958189047,1,0.930232558,"HPGD",1]
["hsa00140","Steroid hormone biosynthesis","1/442","62/8746",0.960316905,1,0.930232558,"DHRS11",1]
["hsa04713","Circadian entrainment","2/442","97/8746",0.960464813,1,0.930232558,"ADCY7/PLCB2",2]
["hsa05217","Basal cell carcinoma","1/442","63/8746",0.962336703,1,0.930232558,"BAX",1]
["hsa04916","Melanogenesis","2/442","101/8746",0.966826015,1,0.930232558,"ADCY7/PLCB2",2]
["hsa04974","Protein digestion and absorption","2/442","103/8746",0.969625803,1,0.930232558,"ATP1B3/COL23A1",2]
["hsa05218","Melanoma","1/442","72/8746",0.976470499,1,0.930232558,"BAX",1]
["hsa05415","Diabetic cardiomyopathy","5/442","203/8746",0.978897379,1,0.930232558,"PDHA1/CD36/MTOR/MAPK8/PLCB2",5]
["hsa04726","Serotonergic synapse","2/442","115/8746",0.982209511,1,0.930232558,"PLCB2/ITPR2",2]
["hsa00980","Metabolism of xenobiotics by cytochrome P450","1/442","78/8746",0.982809519,1,0.930232558,"AKR7A2",1]
["hsa04360","Axon guidance","4/442","182/8746",0.984349226,1,0.930232558,"NRP1/PLCG2/PTK2/ILK",4]
["hsa04932","Non-alcoholic fatty liver disease","3/442","155/8746",0.986671688,1,0.930232558,"MAPK8/PRKAG1/BAX",3]
["hsa05034","Alcoholism","4/442","188/8746",0.987549981,1,0.930232558,"SOS1/HDAC7/CAMKK2/HDAC6",4]
["hsa04610","Complement and coagulation cascades","1/442","86/8746",0.988692384,1,0.930232558,"ITGB2",1]
["hsa04742","Taste transduction","1/442","86/8746",0.988692384,1,0.930232558,"PLCB2",1]
["hsa04260","Cardiac muscle contraction","1/442","87/8746",0.989269517,1,0.930232558,"ATP1B3",1]
["hsa04024","cAMP signaling pathway","5/442","225/8746",0.990401412,1,0.930232558,"ABCC4/ATP2B4/MAPK8/ADCY7/ATP1B3",5]
["hsa05323","Rheumatoid arthritis","1/442","93/8746",0.992164764,1,0.930232558,"ITGB2",1]
["hsa05150","Staphylococcus aureus infection","1/442","96/8746",0.993305286,1,0.930232558,"ITGB2",1]
["hsa04310","Wnt signaling pathway","3/442","174/8746",0.993976858,1,0.930232558,"MAPK8/PLCB2/CUL1",3]
["hsa04550","Signaling pathways regulating pluripotency of stem cells","2/442","143/8746",0.995057988,1,0.930232558,"TCF3/RIF1",2]
["hsa05022","Pathways of neurodegeneration - multiple diseases","13/442","476/8746",0.996345283,1,0.930232558,"CCS/UBA7/MTOR/MAPK8/ATXN3/CASP9/PLCB2/BAX/ITPR2/SPG11/ATXN2/DERL1/WDR41",13]
["hsa05208","Chemical carcinogenesis - reactive oxygen species","4/442","223/8746",0.996878273,1,0.930232558,"PTPN1/MAPK8/PTK2/SOS1",4]
["hsa04390","Hippo signaling pathway","2/442","157/8746",0.99743113,1,0.930232558,"ITGB2/PPP2R1B",2]
["hsa05012","Parkinson disease","5/442","266/8746",0.997973189,1,0.930232558,"UBA7/MAPK8/CASP9/BAX/ITPR2",5]
["hsa03040","Spliceosome","3/442","217/8746",0.999072951,1,0.930232558,"NCBP1/THOC2/THOC1",3]
["hsa05016","Huntington disease","5/442","306/8746",0.9995929649999999,1,0.930232558,"MTOR/MAPK8/CASP9/PLCB2/BAX",5]
["hsa05020","Prion disease","4/442","272/8746",0.999597905,1,0.930232558,"MAPK8/CASP9/BAX/ITPR2",4]
["hsa05010","Alzheimer disease","6/442","384/8746",0.999934584,1,0.930232558,"MTOR/MAPK8/CASP9/PLCB2/NAE1/ITPR2",6]
["hsa04740","Olfactory transduction","1/442","441/8746",1,1,0.930232558,"ARRB2",1]