Profile 1

Within-profile KO and GH frequencies mapped on the metabolic network. For each profile, i.e. each row of the profile matrix

H^{(AFT)}

, we display the within-profile AFT frequencies, expressed for profile

i

and AFT

j

as

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ KO} H_{ik}^{(AFT)}}

or

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ GH} H_{ik}^{(AFT)}}

depending if

j

is a KO or a GH. The resulting value is plotted in green and blue color scales for GH and KO respectively, with edge width proportional to the value. These plots represent the intrinsic functional potential of the different profiles, like Fig. 3.a and unlike Fig. S3 or 3.b which represent the profile contributions to the metagenome.

Profile 2

Within-profile KO and GH frequencies mapped on the metabolic network. For each profile, i.e. each row of the profile matrix

H^{(AFT)}

, we display the within-profile AFT frequencies, expressed for profile

i

and AFT

j

as

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ KO} H_{ik}^{(AFT)}}

or

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ GH} H_{ik}^{(AFT)}}

depending if

j

is a KO or a GH. The resulting value is plotted in green and blue color scales for GH and KO respectively, with edge width proportional to the value. These plots represent the intrinsic functional potential of the different profiles, like Fig. 3.a and unlike Fig. S3 or 3.b which represent the profile contributions to the metagenome.

Profile 3

Within-profile KO and GH frequencies mapped on the metabolic network. For each profile, i.e. each row of the profile matrix

H^{(AFT)}

, we display the within-profile AFT frequencies, expressed for profile

i

and AFT

j

as

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ KO} H_{ik}^{(AFT)}}

or

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ GH} H_{ik}^{(AFT)}}

depending if

j

is a KO or a GH. The resulting value is plotted in green and blue color scales for GH and KO respectively, with edge width proportional to the value. These plots represent the intrinsic functional potential of the different profiles, like Fig. 3.a and unlike Fig. S3 or 3.b which represent the profile contributions to the metagenome.

Profile 4

Within-profile KO and GH frequencies mapped on the metabolic network. For each profile, i.e. each row of the profile matrix

H^{(AFT)}

, we display the within-profile AFT frequencies, expressed for profile

i

and AFT

j

as

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ KO} H_{ik}^{(AFT)}}

or

\frac{H_{ij}^{(AFT)}}{\sum_{k ∈ GH} H_{ik}^{(AFT)}}

depending if

j

is a KO or a GH. The resulting value is plotted in green and blue color scales for GH and KO respectively, with edge width proportional to the value. These plots represent the intrinsic functional potential of the different profiles, like Fig. 3.a and unlike Fig. S3 or 3.b which represent the profile contributions to the metagenome.