{"text_format":"3","workbook":"xlsx","n_sheets":28,"sheets":["Table of Contents","Supplementary Table S1.","Supplementary Table S2.","Supplementary Table S3.","Supplementary Table S4.","Supplementary Table S5.","Supplementary Table S6.","Supplementary Table S7.","Supplementary Table S8.","Supplementary Table S9.","Supplementary Table S10. ","Supplementary Table S11.","Supplementary Table S12.","Supplementary Table S13.","Supplementary Table S14.","Supplementary Table S15.","Supplementary Table S16.","Supplementary Table S17.","Supplementary Table S18.","Supplementary Table S19.","Supplementary Table S20.","Supplementary Table S21.","Supplementary Table S22.","Supplementary Table S23.","Supplementary Table S24.","Supplementary Table S25.","Supplementary Table S26.","Supplementary Table S27. "],"read":"whole","date_system":"1900"}

{"sheet":"Table of Contents","index":0,"n_rows":28,"n_cols":2,"rows_kept":28}
["Tab Number ","Table Name"]
[2,"Supplementary Table S1. - Description of gene expression datasets "]
[3,"Supplementary Table S2. - Summarized information of selected papers of human participants "]
[4,"Supplementary Table S3. - Summarized information of selected papers of mice (Mus musculus) subjects "]
[5,"Supplementary Table S4. - Summarized information of selected papers of human participants and mice (Mus musculus) subjects "]
[6,"Supplementary Table S5. - Risk of Bias Assessment for the selected Human Studies "]
[7,"Supplementary Table S6. - Risk of Bias Assessment for the selected animal (Mus musculus) studies "]
[8,"Supplementary Table S7. -  Risk of Bias Assessment for the selected human and animal (Mus musculus) studies"]
[9,"Supplementary Table S8. - Deafness Variation Database (DVD) and International Mouse Phenotyping Consortium (IMPC) Gene Lists "]
[10,"Supplementary Table S9. - Auditory, Vestibular and Audiovestibular Phenotype Genes According to IMPC "]
[11,"Supplementary Table S10. - Gene Homology Analysis Using BLAST Tool for CIB2, COL9A2, ELMOD1, GRXCR1, KLHDC7B, MARVELD2, MGRN1, NPTN"]
[12,"Supplementary Table S11. - Average expression of genes in P0 mouse auditory and vestibular epithelia, comparing hair cells, epithelial non-hair cells, and non-epithelial cells (Elkon et al., 2015)"]
[13,"Supplementary Table S12. - Average expression of genes in P2 mouse cochlea across apical, middle, and basal turns (Yoshimura et al., 2014)"]
[14,"Supplementary Table S13. - Average expression of genes in adult (6-week) mouse cochlea (Waldhaus et al., 2015)"]
[15,"Supplementary Table S14. – Auditory Brainstem Response (ABR) of genes according to IMPC"]
[16,"Supplementary Table S15. - Active biochemical pathways according to Gene Ontology - Biological Processes in Homosapiens. "]
[17,"Supplementary Table S16. - Active biochemical pathways according to Gene Ontology - Cellular Component in Homosapiens. "]
[18,"Supplementary Table S17. - Active biochemical pathways according to Gene Ontology - Molecular Function in Homosapiens. "]
[19,"Supplementary Table S18.- Active biochemical pathways according to KEGG Reactome in Homosapiens. "]
[20,"Supplementary Table S19.- Possible Transcription Factors according to CollecTRI in Homosapiens.  "]
[21,"Supplementary Table S20. - Active biochemical pathways according to Gene Ontology - Biological Processes in Mus musculus. "]
[22,"Supplementary Table S21. - Active biochemical pathways according to Gene Ontology - Cellular Component in Mus musculus. "]
[23,"Supplementary Table S22. - Active biochemical pathways according to Gene Ontology - Molecular Function in Mus musculus. "]
[24,"Supplementary Table S23.- Active biochemical pathways according to KEGG Reactome in Mus musculus. "]
[25,"Supplementary Table S24.- Possible Transcription Factors according to CollecTRI in Mus musculus. "]
[26,"Supplementary Table S25. – Protein-Protein Interaction Networks According to STRING in Homosapiens."]
[27,"Supplementary Table S26. – Human Phenotype Ontology (HPO) Enrichment "]
[28,"Supplementary Table S27. – Protein-Protein Interaction Networks According to STRING in Mus musculus."]

{"sheet":"Supplementary Table S1.","index":1,"n_rows":7,"n_cols":7,"rows_kept":7}
["Supplementary Table S1. Description of gene expression datasets "]
[]
["Dataset","Tissues","Stage","Species","Cell/Tissue Selection Methods","RNA expression assays ","Reference"]
[1,"Cochlea, Vestibular System","P0-P1","Mus Musculus","Atoh1/nGFP mice and Flow Cytometry","Microarray (MouseRef-6 v2.0 Expression BeadChips)","Elkon et al. 2015"]
[2,"Cochlea, Vestibular System","P0-P1","Mus Musculus","Atoh1/nGFP mice and Flow Cytometry","Rnaseq (NuGEN Ovation RNA-seq V2 System & Ovation Ultralow Library System)","Elkon et al. 2015"]
[3,"Cochlea","Adult (6 weeks)","Mus Musculus","Manual dissection","Microarray (SurePrint G3 Mouse Exon Microarray)","Yoshimura et al. 2014"]
[4,"Cochlea","P2","Mus Musculus","Atoh1-nGFP, Sox2-GFP, Lgr5-EGFP-IRES-CreERT2, Fgfr3-CreERT2, Glast-CreERT2, Ai14-tdTomato mice and Flow Cytometry","Quantitative RT-PCR","Waldhaus et al. 2015"]

{"sheet":"Supplementary Table S2.","index":2,"n_rows":436,"n_cols":15,"rows_kept":436}
["Supplementary Table S2. - Summarized information of selected papers of human participants "]
[]
["DOI","Author/Year","Country","Disease","Design","Sample Size","Sex/Median Age","Main Objective","Gene - List","Variant(s)","Inheritance Pattern","Sequencing or Genomic Analysis ","Hearing Profile","Methodology to Assess Vestibular Function","Vestibular Profile"]
["https://doi.org/10.1038/s41598-025-08801-w","Bae, SH. et al. (2025)","Republic of Korea","Progressive sensorineural hearing loss (SNHL) linked to MYH9 and MYH14 variants","Retrospective Analysis, Observational cohort study","13 patients total – 6 with MYH9 variants and 7 with MYH14 variants","MYH9 group: median age 58.5 years (IQR 27.5); 1 male (16.7%) and 5 females (83.3%) • MYH14 group: median age 54.0 years (IQR 26.0); 5 males (71.4%) and 2 females (28.6%)","o characterize and compare the clinical and audiological phenotypes of patients carrying variants in MYH9 or MYH14, identify novel variants, and evaluate the progression/severity of hearing loss.","MYH9 and MYH14","MYH9: p.R1730C, p.Q1323H, p.Y422C (novel), p.D513Y (novel), p.S1457F (novel). MYH14: p.K898Q, p.A1023V, p.Q25* (congenital case), p.D696N (novel), p.V832I (novel), p.R879Q (novel).","Autosomal dominant for both MYH9 and MYH14 variants.","Next-generation sequencing (whole-exome sequencing or a 207-gene deafness panel), followed by Sanger sequencing for segregation analysis. Variants interpreted per ACMG/AMP guidelines and Deafness Variation Database.","Progressive, high-frequency, late-onset sensorineural hearing loss in both groups. MYH9 group showed more severe hearing loss (41.7% severe-to-profound vs. 14.3% in MYH14). One MYH14 patient had congenital, severe hearing loss (p.Q25*). Pure-tone audiometry (500–8000 Hz) used to classify mild (25–40 dB HL), moderate (40–70 dB HL), severe-to-profound (≥70 dB HL). Median pure-tone thresholds plotted in Fig. 1 of the paper.","Not performed","No explicit vestibular dysfunction reported."]
["https://doi.org/10.1177/00034894251315550","González-Aguado, R. et al. (2025)","Northern Spain","Bilateral, non-syndromic sensorineural hearing loss (SNHL) due to TECTA variants","6-year (2018–2024) observational, prospective, descriptive study of all unrelated patients with bilateral SNHL of unknown cause; genetic screening for TECTA variants","326 probands screened; 7 with pathogenic/likely pathogenic (P/LP) TECTA variants; 8 with VUS variants; 8 relatives with confirmed variants → total 23 cases","Ages ranged from 2 to 91 years; congenital to fifth decade onset. 14/15 probands had a family history (autosomal dominant).","Determine the prevalence of pathogenic, likely pathogenic, and VUS variants in the TECTA gene among patients with bilateral SNHL in northern Spain, and clinically characterize their audiological/vestibular profiles.","TECTA","Pathogenic/LP: c.3107G>A (p.Cys1036Tyr) (n=6), c.5383+6T>A (n=1). VUS: c.5012C>T (p.Ser1671Leu), c.2825G>A (p.Arg942His), c.1443G>A (p.Met481Ile), c.4171G>A (p.Ala1391Thr), c.202G>A (p.Cys671Tyr), c.2945T>C (p.Leu982Pro). One proband had biallelic STRC mutations plus TECTA VUS.","Predominantly autosomal dominant (AD) (14/15 probands had AD family history); no DFNB21-type biallelic recessive cases.","Targeted next-generation sequencing custom panel (SureSelect RNA probes, Illumina MiSeq), median depth 530x, 100% coverage; CNV detection with DECoN; annotation with dbSNP, gnomAD, ClinVar, HGMD; ACMG/AMP guidelines; Sanger sequencing for family segregation","• Bilateral, slowly progressive SNHL with mid-frequency (“cookie-bite”) or gently sloping high-frequency loss.\n• 6 patients with P/LP + 3 with VUS had moderate mid-frequency loss; 5 had moderate at mid frequencies and severe at high frequencies; one slight low-frequency case.\n• Onset from birth to fifth decade; some neonatal screening initially normal.\n• Most fitted with hearing aids; none required cochlear implants.","Data from clinical records: ABR and OAEs in neonates; Video Head Impulse Test (vHIT), videonystagmography (VNG), and BPPV evaluation in selected adults; CT/MRI in three patients to rule out malformations","Most patients: no vestibular complaints or normal testing.\n• Three patients (IDs 1, 15, 20) had recurrent BPPV, treated successfully with Epley maneuvers.\n• One patient with severe motion sickness since infancy.\n• vHIT and VNG normal across those tested.\n• No inner ear malformations on CT/MRI.\n→ Overall suggests cochlear origin with minimal vestibular involvement."]
["https://doi.org/10.1016/j.otoeng.2025.512217","González-Aguado, R. et al. (2025)","Northern Spain","SNHL","Experimental study (auditory physiology)",365,"NA","To determine the prevalence of pathogenic, likely pathogenic and unknown signficance variants in the ACTG1 gene among patients with bilateral SNHL","ACTG1 - DVD"," c.94C>A and c.721G>A","AD / de novo","Next generation sequencing","high-frequency","Clinical history, videonystagmography, vHIT (two patients)","NA"]
["https://doi.org/10.1007/s00405-025-09288-x","González-Aguado, R. et al. (2025)","Northern Spain","SNHL","Experimental study (auditory physiology)",370,"Both / 25","To determine frequency and clinical characteristics of pathogenic, likely pathogenic and unknown signficance in the KCNQ4 gene ","KCNQ4 - DVD","c.777_778delinsCC, c.626 T > G, and c.778G > C","AD","Next generation sequencing","progressive, bilateral, high-frequency","Clinical history, walking acquisition age; no instrumental vestibular testing","NA"]
["https://doi.org/10.1007/s00439-025-02730-4","Serey-Gaut, M. et al. (2025)","France","SNHL","Experimental study (auditory physiology)",14,"NA","To determine frequency and clinical characteristics of pathogenic, likely pathogenic and unknown signficance in the KITLG gene ","KITLG - DVD","c.94 C > T, p.(Arg32Cys)","Hetereozygous","  Targeted Sanger sequencing, Chromosomal microarray analysis","severe, low-frequency","Clinical history (vertigo), walking acquisition age; vestibular tests in 2 patients.","NA"]
["https://doi.org/10.1002/mgg3.70075","Gong, GQ. et al. (2025)","China","Deafness","Experimental study (auditory physiology)",28,"Both, 33","To investigate the audiological and genetic characteristics of a family with missense variation in the KCNQ4 gene","KCNQ4 - DVD","c.701A > G; p.His234Arg","AD","Whole-exome sequencing, Sanger sequencing","high-frequency","Medical history (vertigo/dizziness); no instrumental vestibular testing performed","NA"]
["https://doi.org/10.1002/ohn.1074","Alonso, AV. et al. (2025)","Northern Spain","SNHL","Observational study (auditory physiology)",248,"Both, 64.15","To determine frequency and clinical characteristics of pathogenic, likely pathogenic and unknown signficance in the COCH gene ","COCH - DVD","c.263G>C","AD","Next generation sequencing","low-to-mid frequency","Clinical history (dizziness/instability); video head impulse test (vHIT) and/or videonystagmography (VNG)","Instability secondary to vestibular hypofunction"]
["https://doi.org/10.3390/ijms26041583","Nagy, N. et al. (2025)","Hungary","SNHL","Experimental study (auditory physiology)",5,"Both / 7","To investigate the audiological and genetic characteristics of a family with autosomal dominant non-syndromic hearing loss","TRRAP - DVD","c.5360A>G, p.Lys1787Arg","AD","Whole-exome sequencing","severe, high-frequency","Clinical otoneurological examination; vestibular dysfunction specifically not observed, no instrumental vestibular testing performed.","NA"]
["https://doi.org/10.3390/genes15121592","Grzybowska-Adamowicz, J. et al. (2024)","Poland","SNHL","Experimental study (auditory physiology)",22,"Both / 21.1","To evaluate genotype–phenotype correlations in Polish patients with WFS1-spectrum disorders.","WFS1 - DVD","c.1535T>C and c.2485C>G","AR","Targeted Next Generation Sequencing","low-frequency","NA","NA"]
["https://doi.org/10.1089/gtmb.2023.0550","Bouhouche, A. et al (2024)","Morocco","SNHL","Case series, family study",5,"Both / 22.4","To determine the clinical characteristics and the genetic cause of the first two Moroccan families presenting with WFS.","WFS1 - DVD","c.1329C>G (p.Ser443Arg) and c.1113G>A (p.Trp371Ter)","AR","Whole-exome sequencing","severe hearing loss","NA","NA"]
["https://doi.org/10.5152/iao.2024.231252","Markova, TG. et al. (2024)","Russia","SNHL","Family study, auditory physiology",21,"Both / 12.5","To study the audiological and molecular genetic characteristics of a large family with CEACAM16-associated autosomal dominant nonsyndromic hearing loss.","CEACAM16 - DVD","с.419С>T (p.(Thr140Ile)) ","AD","Whole-exome sequencing, Sanger sequencing","high-frequency","NA","NA"]
["https://doi.org/10.1038/s41598-024-55435-5","Lei, P. et al. (2024)","China","SNHL","Family study, auditory physiology",13,"NA","To investigate the audiological and molecular genetic characteristics autosomal nonsyndromic hearing loss in TBC1D24","TBC1D24 - DVD","c.1459C>T (p.His487Tyr)","AD","Next generation sequencing","progressive, high frequency","Clinical history (vertigo); no vestibular dysfunction reported; no instrumental vestibular testing performed.","NA"]
["https://doi.org/10.1016/j.ijporl.2023.111484","Guo, L. et al. (2023)","China","SNHL","Case series","12 families ","NA","Identify variants underlying low-mid frequency hearing loss, while expanding the genotype-phenotype spectrum of WFS1","WFS1 - DVD","c.2519T > G, p.F840C; c.2048T > G, p.M683R and c.2419A > C,  p.S807R","AD","Whole-exome sequencing, Sanger sequencing","low-to-mid frequency","NA","NA"]
["https://doi.org/10.3390/genes14020457","Velde, HM. et al. (2023)","Dutch-German ","SNHL","Family study, audiovestibular phenotyping",12,"Both / 41","Describe the genotype-phenotype specturm for a novel WFS1 variant","WFS1 - DVD","c.2512C>T p.(Pro838Ser)","AD","Whole-exome sequencing, Sanger sequencing","low-frequency","Anamnesis, dizziness handicap inventory; vestibular tests (caloric, rotational chair, vHIT, o-VEMP, c-VEMP)","abnormal otolith function"]
["https://doi.org/10.1155/2022/5068869","Ma, J. et al. (2022)","China","SNHL","Family study",94,"Both/NA","Identify the variant causing Low-frequency SNHL in the family","WFS1 - DVD","c.2530G > T (p.Ala844Ser)","AD","Next generation sequencing, Sanger sequencing","low-frequency","Clinical history (vertigo) and vestibular tests; results showed no vestibular dysfunction","NA"]
["https://doi.org/10.1186/s12920-022-01289-7","Du, Q. et al. (2022)","China","SNHL","Family study",5,"NA","To investigate the pathogenecity of PDZD7 in patients moderate severe hearing loss.","PDZD7","c.2372del; p.(Ser791fs)","AR","Targeted genome enrichment","moderate-severe hearing loss","Romberg and tandem gait tests; results showed no vestibular abnormalities in affected siblings.","NA"]
["https://doi.org/10.1186/s13023-022-02244-6","Rad, A. et al. (2022)","Morocco, Iran","SNHL","Case Series, Three families study",5,"Both/NA","Identify causal variants in COL9A3, while expanding the genotype-phenotype specturm in Sickler Syndrome","COL9A3","p.(Pro36Argfs*49), p.(Arg402*), p.(Leu119Serfs*10), p.(Gln393Cysfs*25)","AR","Exome sequencing ","moderate-severe hearing loss","NA","NA"]
["https://doi.org/10.1038/s41598-020-63256-5","Morín, M. et al. (2020)","Spain","SNHL","Screening, Family study",531,"Both/NA","Determine the prevalence of EYA4 mutations in spanish patients with NSHL, and identify novel variants","EYA4 ","c.160G>T (p.Glu54*), c.781del (p.Thr261Argfs34), c.1078C>A (p.Pro360Thr), c.1107G>T (p.Glu369Asp), c.1122G>T (p.Trp374Cys), c.1281G>A (p.Glu427Glu), c.1282-1G>A, c.1601C>G (p.Ser534)","AD","Targeted genomic sequencing ","mild to severe ","Clinical history only; no vestibular symptoms or balance problems reported, no instrumental testing performed","NA"]
["https://doi.org/10.3390/genes10100744","Yasukawa, R. et al. (2019)","Japan","SNHL","Experimental study (auditory physiology)",812,"Both/37.1","To investigate the phenotype-genotype correlations in patients with TECTA mutations ","TECTA - DVD","c.5597C>T  (p.Thr1866Met)","AD","Next generation sequencing","Mid-frequency ","Clinical history (onset, vertigo episodes); no instrumental vestibular testing performed","NA"]
["https://doi.org/10.3390/genes10121031","Noman, M. et al. (2019)","Pakistan","Deafness","Family study","7 families","Both/NA","Identify novel homozygous variants families from Pakistan with hearing loss","TMPRSS3, ESRRB, OTOF, LRTOMT, MYO15A, KCNE1, LHFPL5","Novel: TMPRSS3 c.1204G>A (p.Gly402Arg), ESRRB c.322G>T (p.Asp108Tyr), OTOF c.5587C>T (p.Gln1863*); Known: LRTOMT c.208C>T (p.Arg70*), MYO15A c.6371G>A (p.Arg2124Gln), KCNE1 c.226G>A (p.Asn76Asp), LHFPL5 c.494C>T (p.Thr165Met)","AR","Whole-exome sequencing","Bilateral, profound, prelingual","Romberg and tandem gait tests; no balance problems except one KCNE1-variant case","NA"]
["https://doi.org/10.1038/s41431-023-01358-0","Singh, S. et al. (2023)","North American","SNHL","Family study, auditory physiology","147 audiograms, 38 affected descendants","Both/NA","Describe the histofy of novel variant in POU4F3","POU4F3","c.37del","AD","Whole-exome sequencing","Mid-frequency","Questionnaire/interview with vestibular screening; no instrumental vestibular tests performed.","NA"]
["https://doi.org/10.1038/s41431-021-00891-0","Bueno, AS. et al. (2021)","Brazil ","Nonsyndromic hearing loss","Family study","5 families","Both/NA","To determine the prevalence and the origin of MYO3A variant in Brazil","MYO3A","c.2090T>G p.(Leu697Trp)","AD","Targeted Next Generation Sequencing, Sanger Sequencing","Bilateral, progressive","NA","NA"]
["https://doi.org/10.1111/aos.14302","Wang, D. et al. (2019)","China","Stickler Syndrome Type I","Case series",115,"Both/NA","Improve the early diagnosis of Stickler syndrome type 1","COL2A1","c.1435delG and c.184delG; c.1221+1G>A and c.1030C>T","AD / de novo","Next generation sequencing","High frequency","NA","NA"]
["https://doi.org/10.1002/mgg3.70080","Mohseni, M. et al. (2025)","Iran","hearing loss","Family study","74 GJB2 negative families","NA","Determine the genetic cause of hereditary hearing loss in Azeri population","SLC26A4, MYO7A, USH2A, TMPRSS3, TRIOBP, OTOF, MYO15A, LRTOMT, GIPC3, PDZD7,CABP2, GRXCR1, KCNJ10, PTPRQ, SMPX","SLC26A4\nc.2027T>A (p.Leu676Gln), c.1614+1G>C, c.965dup (p.Asn322Lysfs*8), c.2145G>T (p.Lys715Asn), c.919-2A>G;MYO7A\nc.2455C>T (p.Gln819*), c.4413del (p.Arg1472Glyfs*77), c.247C>T (p.Arg83Cys); USH2A\nc.5776+1G>A, c.11864G>A (p.Trp3955*); TMPRSS3\nc.1221del (p.Glu408Argfs*7), c.320G>A (p.Cys107Tyr); TRIOBP\nc.2968C>T (p.Arg990*), c.2296G>T (p.Glu766*), c.2988C>A (p.Tyr996*); OTOF\nc.886del (p.Arg296Alafs14), c.1962dup (p.Pro655Alafs8), c.2417T>C (p.Ile806Thr); MYO15A\nc.8601+2T>G, c.5910+1G>T; LRTOMT\nc.358+4A>C; GIPC3\nc.122C>A (p.Thr41Lys); PDZD7\nc.1576C>T (p.Gln526*), c.1088G>A (p.Trp363*); CABP2\nc.637+1G>T; GRXCR1\nc.720del (p.Ser241Leufs*32); KCNJ10\nc.967T>C (p.Tyr323His); PTPRQ\nc.5871+1G>A; SMPX\nc.11C>A (p.Ser4*)","AR","Next generation sequencing","Bilateral, prelingual, severe-to-profound","Clinical evaluation included audiometry, eye exams, thyroid testing, imaging; no vestibular function tests reported","Syndromic only (Pendred, Usher syndrome)"]
["https://doi.org/10.1007/s00467-024-06507-1","Yadav, M. et al. (2024)","India","Alport Syndrome","Retrospective case series",43,"Both/10 (median age of diagnosis)","Describe clinical, histologic, and genetic specturm of Alport syndrome in India","COL4A5; COL4A4; COL4A3","c.4341del (p.Gly1448Valfs106), c.136G>T (p.Glu46), c.1339+1G>T, c.1779+2T>G, c.4994+1G>A, c.4480del (p.Ser1494Leufs60), c.5020C>T (p.Arg1674), c.634del (p.Pro212fs), c.758_761del (p.Val253Glyfs92), c.4063del (p.Glu1355Asnfs22), c.796C>T (p.Arg266*), c.3570_3580insC (p.Gly1196Trpfs11), c.4698_4701del (p.Phe1566Leufs13), c.63_69del (p.Pro23Argfs19), c.1892dup (p.Gly632Argfs2), c.1634G>A (p.Gly545Asp), c.(141+1_142-1)(2509+1_2510-1)del, c.(4994+1_4995-1)(1_?)dup, c.1443C>A (p.Cys481), c.1258G>A (p.Gly420Arg), c.3446G>A (p.Gly1149Asp), c.3695G>A (p.Gly1232Asp), c.2395G>A (p.Gly799Ser), c.3933C>G (p.Tyr1311*), c.3655C>T (p.Gly1219*), c.1921C>T (p.Arg641*), c.4413_4414del (p.His1471Glnfs21), c.3622del (p.Leu1208), c.2702G>A (p.Gly901Asp)","AR, AD, XL","Next generation sequencing","high-frequency","NA","NA"]
["https://doi.org/10.3390/genes16020123","Maekawa, K. et al. (2025)","Japan","SNHL","Nationwide Screening",7056,"NA","To determine the prevalence and clinical characterisitics the screened patients with hearing loss","OTOGL","c.2770C>T (p.Arg924*), c.2833C>T (p.Arg945*), c.2994C>A (p.Cys998*), c.3140G>A (p.Trp1047*), c.4172+1G>A, c.4863_4864delinsAA (p.Pro1622Thr), c.5380+3_+6del, c.6133_6134del (p.Ala2046Argfs*21), c.6409C>T (p.Glu2137*), c.6467C>A (p.Ser2156*), c.6468delA (p.Lys2158Asnfs*40)","AR","Massively parallel DNA sequencing","mild-to-moderate ","Clinical chart review; documentation of vertigo/vestibular symptoms, but no formal vestibular tests performed","Vestibular symptoms present"]
["https://doi.org/10.3390/genes16010092","Maekawa, K. et al. (2025)","Japan","SNHL","Nationwide Screening",{"v":15684,"d":"15,684"},27.5,"To determine the prevalence and characterisitics of MYO3A associated hearing loss in Japanese cohort by identifying variants","MYO3A","c.1450T>C","AR","Massively parallel DNA sequencing","Late-onset, progressive ","NA","Vertigo"]
["https://doi.org/10.3390/ijms252212169","Ogorodova, N. et al. (2024)","Russia","Usher syndrome ","Retrospective cohort analysis",2415,"Both/NA","To compare the variant spectrum of USH2A gene between syndromic RP and Usher syndrome type 2 in Russian patients","USH2A","p.(Glu4445_Ser4449delinsAspLeu), p.(Trp3955*), p.(Cys934Trp), p.(Arg4192Cys), p.(Cys759Phe), p.(Arg1653*), p.(Trp3955*), c.8682-9A>G, p.(Gly3142*)","AR","Massively parallel DNA sequencing","moderate-severe","No vestibular tests; grouping based on hearing symptoms only","NA"]
["https://doi.org/10.1016/j.ijporl.2024.112082","Morales-Angulo, C. et al. (2024)","Spain","SNHL","Retrospective and prospective cohort study",124,"Both/NA","To determine the prevalence of OTOF variants among SNHL patients in Cantabria","OTOF"," p. Gln829*","AR","Sanger Sequencing","Bilateral, severe-to-profound","Videonystagmography and vHIT; results normal, no vestibular pathology","NA"]
["https://doi.org/10.1371/journal.pone.0309439","Teryutin, FM. et al. (2024)","Russia ","SNHL","Screening, auditory physiology",134,"Both/NA","To characterise heraing phenotypes associated with the variant of GJB2 against other GJB2 genotypes","GJB2","c.-23+1G>A","AR","Sequencing analysis ","mild-to-profound ","NA","NA"]
["https://doi.org/10.3390/genes15091227","Gombojav, B. et al. (2024)","Mongolia","SNHL","Cross-sectional genetic screening",99,"Both/(mean age: 11.2 years)","To determine the genetic variants causing idiopathic SNHL in Mongolian patients","SLC26A4","c.919-2A>G ","AR and AD","Next generation sequencing","moderate-severe","Imaging (CT) used to detect enlarged vestibular aqueduct; no vestibular testing performed","Englarged vestibular aqueduct (EVA)"]
["https://doi.org/10.1038/s41598-024-70795-8","Choi, WH. et al. (2024)","South Korea","SNHL","Case study ","1 proband, with parents for segregation","NA","To identify the ERRB variants in South Korean proband and functionally characterise the variant","ESRRB","c.1144C>T p.(Arg382Cys)","AR","Next generation sequencing","moderate, severe-profound","NA","NA"]
["https://doi.org/10.1007/s11033-024-09740-x","Idyahia, A. et al. (2024)","Morocco","Perrault syndrome","Case Series","2 affected sibl","Both/NA","Identify genetic causes of synfromic hearing loss ","HSD17B4","p. Asn457Tyr and p. Val643Argfs*5","AR","Whole-exome sequencing","Progressive-profound","NA","Balance disorders, regression of walking, frequent falls"]
["https://doi.org/10.1186/s12886-024-03578-4","Serra, R. et al. (2024)","Italy","Usher syndrome ","Screening","3 families","Both/NA","Describe clinical findings and identify the molecular cause of familial USH in Sardinia","USH2A","p.Pro3272Leu","AR","Sanger Sequencing","moderate to severe/profound","Clinical history only; no vestibular abnormalities reported, no instrumental vestibular testing performed","NA"]
["https://doi.org/10.1038/s41598-024-61442-3","Tsukada, K. et al. (2024)","Japan","Hearing loss","Observational comparitive study",39,"Both/(mean: 24.4 years)","Compare vestibular function and symptoms across patients with differencausative hearing loss genes","GJB2, SLC26A4, and CDH23","GJB2: c.235delC, SLC26A4: c.2168A>G (p.H723R), CDH23: c.719C>T (p.P240L)","AR","Massively parallel DNA sequencing","Congenital, severe-to-profound","Patients underwent caloric testing, cVEMP, and oVEMP to evaluate semicircular canal, saccular, and utricular functions","saccular dysfunction, vertigo/dizziness, semicircular canal dysfunction"]
["https://doi.org/10.3390/genes15040489","Sakuma, N. et al. (2024)","Japan","SNHL","SNHL",{"v":15684,"d":"15,684"},"Both/NA","Define the clincal/audiological phenotype and variant specturm of PTPRQ-associated hearing loss","PTPRQ","c.745C>T (p.R249*), c.279T>G (p.Y93*), c.541delA (p.S181Afs*12), c.641C>A (p.S214*), c.1433_1436del (p.S479Kfs*7), c.1617delG (p.M539Ifs*9), c.3206-2A>G, c.3263G>A (p.W1088*), c.4093+1G>A (splice), c.4261G>T (p.E1421*), c.4402+1G>A (splice), c.4815C>A (p.Y1605*), c.5426+2T>C (splice), c.6017dupT (p.I2007Nfs*14).","AR","Massively parallel DNA sequencing ","Congenital/prelingual, high frequency","Patients were asked about vertigo symptoms only; no instrumental vestibular tests performed.","Dizziness/vertigo"]
["https://doi.org/10.1038/s41598-024-57415-1","Watanabe, K. et al. (2024)","Japan","Usher sydnrome","Nationwide Screening",{"v":10042,"d":"10,042"},"Both/NA","Determine prevalence of MYO7A-associated HL and describe clinical featrures","MYO7A","Missense and in-frame deletions","AD and AR","Next generation sequencing","Progressive, severe-profound, congenital","Vestibular dysfunction in USH1B was inferred from delayed walking milestones; no direct vestibular tests","NA"]
["https://doi.org/10.1186/s12920-023-01786-3","Zhang, L. et al. (2024)","China","Hearing loss","Large patient cohort study",{"v":3272,"d":"3,272"},"Both/NA","To investgate the prevalence and clinical features of MPZL2 associated hearing loss","MPZL2","c.220C>T (p.Gln74*), c.68delC (p.Pro23Leufs*2), c.463delG (p.Ala155Leufs*10), c.3G>T (p.Met1?)","AR","Sanger Sequencing","moderate ","NA","NA"]
["https://doi.org/10.3390/genes12101569","Tesolin, P. et al. (2021)","Italy","Pendred Syndrome","Cohort study, auditory physiology",24,"Both/NA","Establish molecular diagnosis and genotype–phenotype correlations in suspected Pendred syndrome patients","SLC26A4","SLC26A4: c.1225C>T (p.R409C), c.704A>G (p.Q235R), c.1489G>A (p.G497S), c.1001+1G>A (splice), c.1149+3A>G (splice), c.1536_1537delAG (p.R512Sfs*14), c.554G>C (p.R185T), c.1263+2T>C (splice), c.1730T>C (p.V577A), c.600G>A (p.Q200Q); MYO5C: c.3592C>T (p.R1198C)","AR","Whole exome sequencing","Prelingual, profound, progressive","Radiology (CT/MRI) for EVA; no vestibular function tests","Vestibular and semicircular canal abnormalities"]
["https://doi.org/10.1016/j.jmoldx.2021.07.007","Lin, Y-H. et al. (2021)","Taiwan and Mongolia","SNHL","Bioinformatics study",95,"Both/NA","Clarify etiology in patients with nonconfirmative monoallelic GJB2 by detecting","GJB2","c.235delC (p.Leu79CysfsTer3), c.35delG (p.Gly12ValfsTer2), c.35dupG (p.Val13CysfsTer35)","AR and AD","Next generation sequencing","mild to profound","NA","NA"]
["https://doi.org/10.1016/j.heares.2021.108329","Roman-Naranjo, P. et al. (2021)","Spain and Switzerland","Meniere Disease","Phenotype Review","62 families","Both/ (mean onset: 38.3 years)","Identify genes and variant combinations underlying familial MD beyond previously reported loci","MYO7A","p.Met1?, p.Trp1545Ter, p.Arg336His, p.Arg836His, p.Arg873Trp, p.Ala2083Thr, p.Arg2209Gln","AD abd AR/Digenic","Exome sequencing and segregation analysis","low frequency","Vestibular symptoms diagnosed per Bárány Society criteria; no functional vestibular tests.","Episodic vertigo"]
["https://doi.org/10.3390/genes12060820","Petrova, NV. et al. (2021)","russia ","SNHL","Stepwise genetic workup",26,"Both/(mean: 18.6 years)","dentify the molecular cause of NSHL in the Chuvash population and estimate the carrier frequency of recurrent variants","GIPC3"," c.245A>G (p.Asn82Ser)","AR","Targeted sanger sequencing and whole exome sequencing","prelingual severe–profound","NA","NA"]
["https://doi.org/10.1002/mgg3.917","Khan, A. et al. (2019)","Pakistan","Nonsyndromic hearing loss","Genetic screening study",40,"Both/NA","Identify sequence variants underlying NSHL and their distribution in a Pakistani cohort","SLC26A4, KCNQ4, MYO7A, MYO15A, TMPRSS3, ESPN, TMC1, GIPC3, LHFPL5, WFS1, DFNB59, GRXCR1, ESRRB, and LRTOMT","c.35delG, c.71G>A, c.231G>A, c.370C>T, −23+1G>A","AR","Targeted Next Generation Sequencing","prelingual severe-to-profound","NA","NA"]
["https://doi.org/10.3390/genes10100772","Wu, C-C. et al. (2019)","Taiwan","SNHL","Nationwide cohort study",{"v":5314,"d":"5,314"},"Both/NA","Define genetic epidemiology of HHI in Taiwan, identify common and unique variants, and assess genotype–phenotype correlations.","GJB2, SLC26A4, OTOF, MYO15A, MTRNR1","GJB2: c.109G>A (p.Val37Ile), c.235delC (p.Leu79Cysfs3), c.299_300delAT (p.His100Argfs14); SLC26A4: c.919-2A>G, c.2168A>G (p.H723R); OTOF: c.5098G>C (p.Glu1700Gln); MYO15A: c.3524dupA (p.Ser1176Valfs*14), c.8182C>G (p.Arg2728Gly), c.3757-32_3757-1del, c.4101C>A, c.4457G>T, c.4760T>C, c.4761_4762insGTTTCTAT, c.5443C>A, c.6956+1G>A, c.8602-1G>C, c.9408G>C; MTRNR1: m.1555A>G.","AR","Next generation sequencing","Mild, progressive","NA","Englarged vestibular aqueduct (EVA)"]
["https://doi.org/10.3390/genes11030273","Oka, SI. et al. (2020)","Japan","SNHL","Multicentre genomic study",{"v":8074,"d":"8,074"},"Both/NA","Define the frequency, mutational spectrum, and clinical course of MYO6-associated hearing loss in a large national cohort and test the cellular impact of missense variants.","MYO6","c.374C>A (p.Pro125His), c.604A>G (p.Asn202Asp), c.614G>A (p.Arg205Gln), c.647A>T (p.Glu216Val), c.1376G>A (p.Gly459Asp), c.1455T>A (p.Asn485Lys), c.2111G>A (p.Gly704Asp), c.2438G>C (p.Arg813Pro), c.3746T>C (p.Phe1249Ser), p.Arg1166*","AD","Massively parallel DNA sequencing","mild-moderate, progressive","NA","Vertigo"]
["https://doi.org/10.1038/s41598-020-60259-0","Shinagawa, J. et al. (2020)","Japan","SNHL","Nationwide cohort study",{"v":7408,"d":"7,408"},"Both/NA","Define the prevalence, variant spectrum, and genotype–phenotype correlations of EYA4-associated hearing loss in Japan","EYA4",null,"AD","Targeted genome enrichment","mild-moderate, high frequency","NA","NA"]
["https://doi.org/10.1002/mgg3.1367","Guan, J. et al. (2020)","Japan","SNHL","Nationwide cohort study",{"v":7408,"d":"7,408"},"Both/NA","Define the prevalence, variant spectrum, and genotype–phenotype correlations of EYA4-associated hearing loss in Japan","EYA4",null,"AD","Targeted genome enrichment","mild-moderate, high frequency","NA","NA"]
["https://doi.org/10.1016/j.ijporl.2020.110143","Liu, Xiao-Wen et al. (2020)","Northern China","SNHL","Stepwise genetic workup",398,"Both/8 years","Define regional mutation spectra/frequencies of common deafness genes","GJB2, SLC26A4","c.235delC, c.109G>A and c.299_300delAT ;  c.919-2A>G, c.2168A>G and c.1174A>T","AR","Targeted Next Generation Sequencing","severe-to-profound bilateral","NA","NA"]
["https://doi.org/10.1038/s10038-020-0783-1","Cesca, F. et al. (2020)","North-East of Italy","Usher syndrome ","Screening",217,"Both/(mean: 19 years)","etermine how often USH-gene mutations underlie “isolated” HL and delineate the phenotypic variability","CDH23, USH2A, MYO7A, ADGRV1, PCDH15, USH1C","CDH23: c.8561–1G>C ","AR","NGS targeted gene-panel ","mild-profound","Vestibular evaluation; areflexia in PCDH15-mutated siblings","vestibular areflexia"]
["https://doi.org/10.1016/j.ijporl.2020.110247","Markova, TG. et al. (2020)","Russia","SNHL","Clinical/Genetic characterisation",28,"Both/NA","Define the audiological phenotype and stability of STRC-linked hearing loss and delineate the underlying variant spectrum (large deletions vs point mutations) in a Russian cohort","STRC","STRC: c.4402C>T (p.Arg1468Ter), c.2171_2174delTTTG (p.Val724Glyfs*6), c.4057C>T (p.Gln1353Ter), c.4399G>A (p.Val1467Ile), c.5275C>T (p.Arg1759Ter), c.4765G>A (p.Val1589Ile)","AR","Sanger Sequencing","mild-to-moderate ","STRC mutations cause congenital, stable, mild-to-moderate hearing loss.","NA"]
["https://doi.org/10.1186/s12881-020-01153-4","Singh, K. et al. (2020)","North India","SNHL; Vertigo","Screening",200,"Both/NA","To determine the prevalence and variant spectrum for genetic caused deafness in Indian cohort compared to western panels","SLC26A4, GJB2, TMPRSS3 and TMC1","GJB2: c.71G>A (p.Trp24Ter), c.231G>A (p.Trp77Ter); SLC26A4: c.1001G>T (p.Gly334Val), c.1003T>C (p.Phe335Leu), c.1226G>C (p.Arg409Pro), c.1468A>C (p.Ile490Leu)","AR","Next generation sequencing","NA","NA","NA"]
["https://doi.org/10.1007/s00405-020-06050-3","Liu, Y. et al. (2020)","China","Enlarged vestibular aqueduct ","Family-based study","17 families; 21 probands","Both/NA","To undertake a comprehensive EVA mutation detection and expand the mutation spectrum of the genes","SLC26A4; FOXI1; KCNJ10","LC26A4: c.919-2A>G, c.416G>A (p.Gly139Glu), c.823G>A, c.1027G>C, c.1343C>T, c.1975G>C, FOXI1: c.214C>A, KCNJ10: c.1054C>A","AR","PCR sequencing panel, Next-generation sequencing","Congenital, prelingual, profound and severe","NA","Englarged vestibular aqueduct (EVA)"]
["https://doi.org/10.1007/s11033-020-06016-y","Noman, M. et al. (2020)","Pakistan","prelingual hearing loss","Large pedigree study","2 families","Both/NA","To identify the genetic cause of prelingual hearing loss in two large consanguineous Pakistani families","USH1C; SLC26A4","c.877-1G > A ; c.716 T > A, p.(Val239Asp)","AR","Whole-exome sequencing","prelingual, moderate-profound","Romberg and tandem gait tests; vestibular areflexia confirmed in USH1C family.","Vestibular areflexia"]
["https://doi.org/10.1007/s11033-020-06037-7","Park, HR. et al. (202)","Pakistan","prelingual hearing loss","Multi-family based study","5 familites","Both/NA","To identify the genetic causes of hearing loss in families in Pakistan","CABP2; CDH23; ESRRB; TMIE.","ESRRB: c.787+1G>A; CABP2: c.637+1G>T; CDH23: c.7814A>G; c.242G>A","AR","Whole-exome sequencing","severe to profound","NA","NA"]
["https://doi.org/10.3390/genes12020274","Kabahuma, RI. et al. (2021)","Indigenous South African","SNHL","Family-based study",94,"Both/NA","Identify the genetic causes of prelingual autosomal-recessive (DFNB) hearing loss in Pakistani consanguineous families","MYO7A","p.Gly329Asp, p.Arg373His, p.Tyr1780Ser, and p.Pro2126Leufs*5","AR","Whole-exome sequencing","severe to profound","Clinical vestibular exam per “Ten-minute dizzy patient”; one subjective vestibular defect.","NA"]
["https://doi.org/10.1002/mgg3.1634","Xiao, C. et al. (2021)","China","Hearing loss","Family-based study","4 families","Both/NA","Identify the genetic causes of hearing loss in four Chinese families","SLC26A, GJB2, CDH23, POU3F4","c.919-2A>G/c.1985G>A in SLC26A4; c.109G>A (p.V37I) in GJB2; c.331C>T/c.625-5C>T/c.5717G>A in CDH23; c.138T>C in POU3F4 ","AR, mtDNA, XL","Next generation sequencing","moderate to profound,congenital","NA","NA"]
["https://doi.org/10.1016/j.heares.2021.108227","Na, G. et al. (2021)","Korea","SNHL","Prospective cohort study",10,"Both/NA","To define genotype–phenotype correlations for MYO15A (DFNB3) by variant domain","MYO15A","c.900delT (p.Pro301Argfs*143);  c.4879G > T (p.Glu1627*) ","AR","Whole exome sequencing","severe-to-profound ","NA","NA"]
["https://doi.org/10.3390/genes12050684","Brozkova, D. et al. (2021)","Czech Republic and Slovakia","SNHL","Cross-sectional genomic study","31 for NES ad 49 for WES","NA","To determine if unexplained monoallelic GJB2 cases have a second pathogenic variant ","GJB2","c.35delG","AR","Next generation sequencing","prelingual, moderate-profound","NA","NA"]
["https://doi.org/10.1038/s41431-020-00790-w","Hirsch, Y. et al. (2021)","Ashkenazi Jewish","SNHL","Multicentre genetic study","80 AJ families","NA","To establish pathogenicity of the relatively common synonymous MYO15A variant","MYO15A","c.9861 C > T","AR","Sanger Sequencing","mild-moderate, progressive","NA","NA"]
["https://doi.org/10.3892/etm.2021.10044","Neagu, A. et al. (2021)","Romanian","SNHL","Cross-sectional cohort study",34,"Both/(mean: 4.62 years)","To assess the prevalence of GJB2 founder variants, in Romanian children","GJB2","35delG, and W24X","AR","PCR-based screening","severe to profound, congenital","NA","NA"]
["https://doi.org/10.1007/s11596-021-2422-2","Gao, Y. et al. (2021)","China","SNHL","Retrospective cohort study",51,"Both/(mean: 41.7 years)","Investigate whether common deafness-gene variants contribute to susceptibility and outcomes in Chinese patients with SNHL","GJB2, SLC26A4, COCH, CDH23, OTOF, SLC17A8, KCNE1","GJB2: p.V37I, p.I203T, p.F191L; GJB3: p.Ala194Thr; SLC26A4: c.601-17C>T, p.Thr94Ile, c.919-2A>G, p.Asp661Glu, p.His723Arg; COCH: p.Val204Met, p.Arg91Gln.; CDH23: p.Val2283Ile; OTOF: c.4023+1G>A; p.Asp398Glu; p.Arg1676Cys; SLC17A8: p.Ala374Ser.; KCNE1: p.Ala8Val, p.Asp85Asn.","NA","Targeted high-throughput sequencing","mild-profound","Vestibular dysfunction inferred from clinical diagnosis of vertigo; no formal vestibular testing.","Vertigo"]
["https://doi.org/10.20344/amp.13781","Reis, CS. et al. (2021)","Portugal","SNHL; Vertigo","Clinical cohort, and population screening study",147,"NA","Estimate the carrier frequency of less-common GJB2 variants in a Portuguese community sample and compare with a clinic cohort","GJB2","p.Phe83Leu, p.Arg127His, p.Val153Ile, p.Val95Met and p.Asn206Ser,","AR","Sanger Sequencing","mild-profound","NA","NA"]
["https://doi.org/10.3390/genes12101578","Choi, Soon-II. et al. (2021)","Korea","Stickler Syndrome ","Retrospective multicentre cochort study",37,"Both/(mean: 19.6 years)","Retrospective multicenter analysis to define the genetic spectrum if COL11A1 and COL2A1 and clinical features in Korean patients with Stickler syndrome","COL11A1; COL2A1","c.1693C>T, c.2003del, c.3106C>T","AD","Whole-exome sequencing, Sanger sequencing","Hearing difficulties present","NA","NA"]
["https://doi.org/10.1097/aud.0000000000001099","Sebastien P F JanssensdeVarebeke et al. 2021","Belgium and Netherlands","SNHL","Prospective cohort study",111,"Both/NA","Define milestone ages and the natural history of hearing decline in DFNA9 due to COCH gene mutation","COCH - DVD","p.Pro51Ser ","AD","NA (No sequencing was made)","high-frequency, progressive","Vestibular function assessed by comprehensive vestibular examination (e.g., caloric testing, vHIT, VEMP, rotatory chair), alongside audiological investigations","NA"]
["https://doi.org/10.25122/jml-2021-0152","Anwar Madlool Al-Janabi et al. (2021)","Iraq","SNHL","Molecular genetics study",95,"Both/NA","To investigate the frequency of three common GJB2 mutations in Iraqi patients","GJB2","c.35delG and c.235delC ","AR","PCR-RFLP","severe to profound, congenital","Vestibular function assessed by comprehensive vestibular examination (e.g., caloric testing, vHIT, VEMP, rotatory chair), alongside audiological investigations","NA"]
["https://doi.org/10.1038/s41598-021-01876-1","Pavlenkova, Z. et al. (2021)","Slovakia","SNHL","Cross-sectional genetic screening",30,"NA","To identify the causative variants underlying SNHL","TECTA, DIAPH1, MYO7A, TMC1, MYO15A, OTOGL, TMPRSS3, TSPEAR, COL4A5","TECTA: p.Cys650Arg, p.Gly1858Glu*, p.Thr1866Met, p.Arg1890Cys, p.Tyr1942Cys, p.Lys2150Asnfs*9; OTOGL: p.Gln520*, c.4032_4054+30del; TMPRSS3: p.Arg106Cys; COL4A5: p.Gly472Glu","AD, AR, XL","Whole exome sequencing","Congenital, mild to profound","NA","NA"]
["https://doi.org/10.1177/00469580211055571","Bian, P. et al. (2022)","Northern China","SNHL","Molecular epidemiological study",1330,"Both/11 years","To investigate the prevalence, ethnic specificity, and mutation spectrum of GJB2 in major ethnic minorities of Northwest China","GJB2","c.235delC, c.109 G > A, c.299-300delAT, and c.35delG ","AR","Sequence Scanner V25.0","moderate-to-severe ","NA","NA"]
["https://doi.org/10.1186/s12920-022-01201-3","Fu, Y. et al. (2022)","China","SNHL","Multicentre/prospective cohort study",2263,"Both/NA","To assess the frequency of MYO15A variants in Chinese NSHL and analyze the genotype–phenotype correlations","MYO15A","c.10245_10247delCTC","AR","Next-generation sequencing ","mild-profound, congenital, progressive","NA","NA"]
["https://doi.org/10.1007/s00439-021-02368-y","Kyung Seok Oh. et al. (2022)","Korea","SNHL","Phenotype-genotype correlation study",26,"NA","Audioprofile variability of COCH variants by domain, and the molecular mechanisms underlying domain-specific phenotypes","COCH","p.Phe230Leu","AD","exome sequencing","mild-profound, congenital, progressive","Vestibular testing included caloric, vHIT, rotary chair, videonystagmography in LCCL carriers","NA"]
["https://doi.org/10.5152/iao.2022.21220","Wang, Y. et al. (2022)","Northwestern China","SNHL","Cross-sectional screening",{"v":2673,"d":"2,673"},"Both/(mean: 12.5 years)","To determine the incidence of two hotspot mutations, in northwestern chinese SNHL cohorts","SLC26A4","c.919-2A>G","AR","Direct Sanger Sequencing","severe to profound","NA","Vestibular hypofunction and Episodic vertigo"]
["https://doi.org/10.1136/jmedgenet-2020-107594","Bong Jik Kin. Et al. (2022)","Republic of Korea","Down-sloping non-syndromic sensorineural hearing loss (SNHL)","Prospective cohort","1055 total SNUBH cohort → 47 in the Teenager–Young Adult Down-sloping SNHL subcohort; 6 diagnosed with LOXHD1-related deafness (12.8% of 47; 33.3% of genetically confirmed cases); +8 additional LOXHD1 patients from SNUBH/CNUH → total 14 DFNB77 subjects (11 pedigrees)","Ages 7 months–34 years across LOXHD1 cohort (probands and family members); both sexes represented","Identify and characterise LOXHD1 variants in teenagers and young adults with down-sloping SNHL; explore genotype–phenotype correlations and test whether transcript 6 is necessary and sufficient for normal hearing","LOXHD1","Two splice region variants accounted for most alleles: c.4212+1G>A (variant 43) and c.5271+5G>C (variant 56). Other recurrent/novel variants: c.3281A>G (p.Asp1094Gly), c.2641G>C (p.Gly881Arg), c.3727C>T (p.Arg1243Trp), c.4600_4601del, c.4530+2_+3insT, c.5390dup (frameshift). Six variants were novel.","AR","Whole-exome sequencing of probands; Sanger confirmation; ACMG/AMP (Hearing Loss Expert Panel) variant classification; minigene splicing assays for c.4212+1G>A and c.5271+5G>C; RT-PCR from mouse cochlea to verify transcript 6 expression; 3D molecular modelling of p.Gly881Arg variant; STR genotyping to assess founder allele c.4212+1G>A","Down-sloping high-frequency SNHL in teens → flattening severe-profound by 30s; low-frequency hearing often preserved. Genotype–phenotype correlation: c.4212+1G>A (stronger splice defect) had significantly poorer 8 kHz thresholds vs c.5271+5G>C (p=0.048). Two subjects underwent cochlear implantation with excellent post-CI speech scores, Progressive; mild–moderate in teens; severe-profound by 20s–30s.","Not systematically performed; paper primarily focused on audiological phenotype. No explicit vestibular tests","na"]
["https://doi.org/10.1016/j.neurobiolaging.2021.12.004","Bally JF. et al. (2022)","Dutch-Canadian","ANHL","Family-based study",10,"Both/NA","To identify genetic variants responsible for the combination of hearing loss, vestibular imbalance, and tremor","COCH","p.P51S","AD","whole genome analysis ","Progressive, profound","Bilateral vestibular loss confirmed with detailed vestibular testing in affected carriers.","Tremor"]
["https://doi.org/10.1007/s11033-022-07245-z","AitRaise, I. et al. (2022)","Morocco","SNHL","Family-based study","6 families","NA","To identfiy the molecular causes of herediary hearing loss in Moroccan families","GJB2, COL4A3, ATP6V1B1 and EDNRB","GJB2: p.Arge184Gln; COL4A3: c.3829G>A (p.Gly1277Ser); ATP6V1B1: c.1155dupC (p.Ile386HisfsTer56); EDNRB: 1:c.1225C>T (p.Arg409Trp)","AD","whole exome sequencing","Severe, prelingual, profound","NA","NA"]
["https://doi.org/10.3390/ijms23116029","Ozięelo, D. et al. (2022)","Poland","Partial Deafness","Cross-sectional genetic screening",40,"Both/(mean onset: 13 years)","Define the molecular basis of partial deafness across two clinically relevant partial deafness subtypes","OSBPL2 and SYNE4","KCNQ4: c.940C>A (p.Pro314Thr); OSBPL2: c.158_159del (p.Gln53ArgfsTer100); SYNE4: c.692G>A (p.Gly231Glu), c.1032-2A>C; CDH23: c.2005C>T (p.Pro669Ser) + c.2864G>T","AD and AR","high throughput sequencing ","progressive, severe-profound","NA","NA"]
["https://doi.org/10.7717/peerj.14514","Petrova, N. et al. (2023)","Republic of North Ossetia-Alania","NSNHL","Genetic epidemiology study",117,"Both/(mean: 19.87)","To assess the genetic and allelic heterogeneity of NSNHL in North Ossetia–Alania"," GJB2; MYH14; MYO15A; POU3F4","c.35delG and c.358_360delGAG","AD, AR, XL","Targeted genotyping and Sanger sequencing","prelingual, profound","Detailed vestibular testing: bilateral vestibular loss confirmed in multiple affected family members.","NA"]
["https://doi.org/10.1038/s41439-019-0068-4","Ganaha, A. et al. 2019","Okinawa Islands","SNHL","Case series/Family-based study",98,"NA","To describe clinical features of OTOG variant associated with SNHL","OTOG","c.330C>G, p.Tyr110*","AR","next-generation sequencing","Moderate ","Caloric test in one patient; no vestibular dysfunction detected.","NA"]
["https://doi.org/10.1002/mgg3.2015","Kabahuma, RI. et al. (2022)","Indigenous South African","SNHL","Family-based study",94,"NA","To clarify how TRIOBP R1/R2 repeat-motif variants segregate with DFNB28 in indigenous South Africans","TRIOBP","c.572delC (p.Pro191Argfs50), c.3510_3513dupTGCA (p.Pro1172Cysfs13), c.505C>A (p.Asp168Glu), c.3636T>A (p.Leu1212Gln)","AR","target sequencing","Prelingual, profound","NA","NA"]
["https://doi.org/10.1002/jcla.24896","Lan, Ying. Et al.. (2023)","China","Sudden SNHL","Hospital-based case study","195 + 182","Both/(mean: 71.9 years)","To gest association of PCDH15 SNPs with SSNHL susceptibility and severity","PCDH15","rs7095441 ","NA","Targeted SNP genotyping","mild-profound, low-high frequency","NA","Vertigo"]
["https://doi.org/10.1016/j.ijporl.2023.111635","Li, W. et al. (2023)","China","NSHL","Restrospective cohort study",385,"NA","Estimate prevalence of MPZL2-related HL in a Chinese cohort","MPZL2","c.220C>T (p.Gln74Ter), c.463delG (p.Ala155fs), ","AR","Whole exome sequencing, Sanger sequencing","mild-moderate, progressive, congenital","NA","NA"]
["https://doi.org/10.1016/j.ekir.2023.07.010","Solanki, KV. Et al. (2023)","United States of America","Alport Syndrome","Population-based cohort",{"v":174418,"d":"174,418"},"Both/(mean: 59.1 years)","To define penetrance and phenotypic spectrum of autosomal dominant Alport syndrome","COL4A3","Gly695Arg","AD","whole exome sequencing","NA","Vestibular function not systematically assessed; only bilateral sensorineural hearing loss via ICD codes.","NA"]
["https://doi.org/10.1016/j.jmoldx.2023.07.005","Chiang, Yu-Ting. Et al. (2023)","Taiwan","SNHL","Case-control association study",35,"NA","Investigate genomic underpinnings of phenotypic variability in GJB2 p.V37I homozygotes","GJB2","p.V37I","AR","next-generation sequencing","severe-to-profound","NA","NA"]
["https://doi.org/10.1016/j.heliyon.2023.e21185","Tian, Y. et al. (2023)","Henan, China","SNHL","Case-control study",2178,"Both/NA","To establish allele frequencies of 15 common deafness variants in Henan, China, and compare between HL and normal populations","GJB2, GJB3, SLC26A4","GJB2 c.235delC variant, GJB3 c.538C > T variant and SLC26A4 c.919-2A > G ","AR, AD, mtDNA","DNA microarray","Mixed severity","NA","NA"]
["https://doi.org/10.3390/ijms242316763","Sakata, A. et al. (2023)","Tokyo","SNHL","Restrospective cohort study",75,"Both/NA","Assess whether hearing loss severity can be predicted by mutation type","GJB2","p.Leu79Cysfs*3","AR","Next-generation sequencing, Sanger Sequencing","Mild to profound","NA","NA"]
["https://doi.org/10.1002/mgg3.741","Shang, S. et al. (2019)","China","Alport Syndrome","Family-based study","7 families","Both/NA","To correlate mutation type and location in COL4A3, COL4A4, and COL4A5 with phenotypic severity","COL4A3, COL4A4, COL4A5","COL4A5: c.443C>T (p.Pro148Leu), c.1289C>A (p.Ala430Asp), c.2366_2383del, c.3188G>A (p.Gly1063Asp), c.4473T>A (p.Tyr1491X); COL4A3: c.971G>A (p.Gly324Asp), c.4411_4412del; COL4A4: c.3782G>A (p.Gly1261Glu)","XL, AR, AD","High throughput sequencing, Sanger Sequencing","severe","NA","NA"]
["https://doi.org/10.3390/genes10060429","Posukh, Olga L. et al. (2019)","Southern Siberia, Russia","Deafness","Moledular Epidemiology study","220 + 157","Both/NA","To determine the prevalence and mutational spectrum of GJB2 variants in the Tuvinian population","GJB2"," p.Trp172Cys (c.516G>C)","AR","Sanger Sequencing","Congenital, severe to profound","NA","NA"]
["https://doi.org/10.3389/fgene.2019.00501","Elayne E Santana. Et al. (2019)","Cuba","Usher Syndrome","Cross-sectional genetic screening",11,"Both/NA","To define the molecular basis of Usher syndrome (USH) in Cuban patients and report novel mutations","USH2A, ADGRV1, CDH23, PCDH15, and CLRN1","c.619C>T (p.Arg207∗) in CLRN1 ; c.4488G>C (p.Gln1496His) in CDH23; c.4488G>C","AR","Next generation sequencing","severe to profound, moderate, progressive","Caloric test and brainstem auditory evoked potentials (BAEP) were used","Variable vestibular dysfunction"]
["https://doi.org/10.1371/journal.pone.0215932","Yoh-Ichiro Iwasa. Et al. (2019)","Japan","SNHL","Nationwide multicentre study",{"v":2265,"d":"2,265"},"Both/NA","To clarify the frequency, mutational spectrum, and clinical background of OTOF-related hearing loss in Japan","OTOF","Foounder mutation: p.R1172Q; Pathogenic and Likely Pathogenic: p.R425X, p.Y474X, p.W717X, p.L1003fs, p.Y1064X, p.Q1072X, p.I1449fs, p.R1856Q, p.R1172Q, c.4960+2T>C, p.P489S, p.H513R, p.R1583H, p.R1792C, p.R1792H","AR","Masively parallel sequencing","mild-profound, prelingual, non-progressive","Clinical vertigo history recorded; 96.9% of OTOF patients reported no vertigo.","NA"]
["https://doi.org/10.1080/13816810.2019.1571615","Pablo T Romero. Et al. (2019)","South America","Corneal Dystrophy and Perceptive Deafness ","Clinical-genetic study",5,"NA","To describe clinical features of CDPD","SLC4A11","c.2233_2240dup TATGACAC, p.(Ile748Metfs*5)","AR","Sanger Sequencing","Progressive, mild-moderate","NA","NA"]
["https://pubmed.ncbi.nlm.nih.gov/30942159/","Xiao, Shu-Ying. Et al. (2019)","China","SNHL","Family-based study",21,"NA","Identify the genetic cause of autosomal dominant, progressive, non-syndromic hearing loss in a Chinese family","EYA4","c.1855T&gt;G","AD","targeted exome sequencing","mid frequency","NA","NA"]
["https://doi.org/10.1038/s41598-019-40586-7","Yokota, Y. et al. (2019)","Japan","SNHL","Large mutlicenter cohort study","1025 +125","Both/NA","To determine the prevalence of STRC deletions and characterise associated clinical features","STRC","Deletions","AR","copy number variants ","mild-to-moderate ","NA","NA"]
["https://doi.org/10.3389/fgene.2019.00076","Gallego-Martinez, A. et al. (2019)","Spain","Meniere's Disease","Case-control study",890,"NA","To assess whether sporadic MD patients carry an excess of rare variants in hearing loss","GJB2, USH1G, SLC26A4, ESRRB, and CLDN14.","chr2:70527974 G>A","Complex;potential multiallelic/oligogenic contribution","Targeted sequencing","low to mid frequency","Diagnosis of Ménière’s disease relied on clinical vertigo criteria; no vestibular tests performed.","Episodic vertigo"]
["https://doi.org/10.1371/journal.pone.0211261","Liu, Wei-Hsiu","Taiwan","SNHL","Genetic screening study",41,"Both/NA","Identify rare variants and correlate genetic findings","MYO15A, TMC1, MYH14, MYO3A, ACTG1, COL11A2, DSPP, GRHL2, and WFS1","ACTG1 p.(Thr277Ile)","AD, AR","Massive Parallel Sequencing","severe to profound","NA","NA"]
["https://doi.org/10.1016/j.amjoto.2018.07.022","Azadegan-Dehkordi, F. et al. (2018)","Iran","SNHL","Linkage study ",40,"Both/NA","To determine SLC26A4’s contribution to ARNSHL in Iranian pedigrees and report the regional mutation spectrum","SCL26A4","c.493A>C","AR","Sanger Sequencing","Profound","Temporal bone CT-scan performed","NA"]
["https://doi.org/10.1007/s00405-018-5083-4","Kecskeméti, N. et al. (2018)","Hungary","NSHL","Cross-sectional genetic screening","239 + 160 ","Both/(mean: 28.9 years)","To define GJB2 mutation frequency/spectrum and relate genotypes to age of onset and HL severity in a large Hungarian NSHL cohort","GJB2","c.35delG","AD","Sanger sequencing / Next generation sequencing","severe to profound","Vestibular disorders excluded using radiological imaging (CT/MRI) during differential diagnosis.","NA"]
["https://doi.org/10.1186/s13104-018-3647-4","Carvalho, S. et al. (2018)","Brazil ","SNHL","Case-control screening study","88+96","Both/NA","Determine SLC26A4 mutation contribution in Brazilian prelingual NSHL after common gene screening","SLC26A4","c.-66C>G (rs17154282)","AR","Sanger Sequencing","Prelingual, profound, non-progressive","NA","NA"]
["https://doi.org/10.1186/s12881-018-0585-x","Nonose, R. et al. (2018)","Brazil ","Pendred Syndrome","Linkage and phenotype study",15,"NA","To determine the frequency and spectrum of SLC26A4 mutations contributing to hereditary hearing loss in Brazilians","SLC26A4","c.1003 T > G (p. F335 V), c.1553G > A (p.W518X), c.2235 + 2 T > C (IVS19 + 2 T > C","AR","Sanger sequencing","Severe to profound","Vestibular assessment via CT/MRI imaging; EVA or cochleovestibular malformations documented in some patients.","Enlarged vestibular aqueduct (EVA)"]
["https://doi.org/10.3390/medicina54020028","Plevova, P. et al. (2018)","Moravia-Silesia of the Czech Republic","SNHL","Cross-sectional genetic study",200,"Both/ (mean: 16.9 years)","Define the genetic etiology of NSHL in Moravia-Silesia, including prevalence and spectrum of GJB2 mutations","GJB2","c.35delG, p.Trp24*, p.Met34Thr, p.Val37Ile, p.Met34Thr, p.Leu90Pro, c.235delC, c.313_326del14, p.Ser139Asn, p.Gly147Leu.","AR","Sanger Sequencing","severe to profound","NA","NA"]
["https://doi.org/10.1016/j.ijporl.2018.01.006","Asgharzade, S. et al. (2018)","Iran","ARNSHL","Family-based study","1 family","NA","To identify the causative variant in an Iranian ARNSHL pedigree when common DFNB causes were excluded.","GIPC3"," c.472G > A (p.Glu158 Lys)","AR","Sanger sequencing, Targeted Next generation sequencing","severe to profound, across all frequencies","NA","NA"]
["https://doi.org/10.1007/s00508-017-1230-y","Parzefall, T. et al. (2018)","Austria","SNHL","Family -based study","1 family","NA","To assess the molecular diagnosis of late-onset, progressive AD SNHL","COCH","c.151C>T missense (p.Pro51Ser)","AD","Whole exome sequencing","Postlingual, progressive, high frequncies and expands to pantonal, severe to profound","Pure-tone audiometry, speech tests, CT/MRI; index patient showed bilateral vestibular areflexia.","Bilateral areflexia"]
["https://doi.org/10.1007/s00439-018-1885-0","Li, W. et al. (2018)","China","ADNSHL","Family-based study",16,"Both/NA","To identify the causative gene of progressive, autosomal dominant NSHL in a large Chinese family","ELMOD3","c.512A > G","AD","Sanger sequencing / whole exome capture sequencing ","Progressive, post-lingual, severe to profound","NA","NA"]
["https://doi.org/10.1016/j.ijporl.2017.09.001","Huang, S. et al. (2017)","China","SNHL","Case-control prevalence study","5700 + 4,600","NA/34 years","To determine whether the variant is associated with hearing loss and clarify its pathogenic relevance","GJB3","c.538C>T (p.R180*)","AD","Direct Sequencing","moderate to profound","NA","NA"]
["https://doi.org/10.1089/gtmb.2017.0130","Tlili, A. et al. (2017)","United Arab Emirates","ARNSHL","Cross-sectional genetic prevalence study",50,"Both (mean: 33 years)","To determine the prevalence and spectrum of GJB2 mutations in UAE ARNSHL patients","GJB2","p.Cys169Tyr","AR","Sanger sequencing","severe to profound","NA","NA"]
["https://doi.org/10.1016/j.heares.2017.09.013","Kytövuori, L. et al. 2017","Finnish","age-related hearing impairment","Family-based study",20,"NA","To test whether rare WFS1 variants contribute to age-related hearing impairment","WFS1 - DVD","p.Tyr528His","AD","Sanger Sequencing","High-frequency","NA","NA"]
["https://doi.org/10.1111/ahg.12207","Luo, J. et al. 2017","Shandong Province, China","cochlea implants","Cross-sectional genetic screening",535,"NA/(mean: 3.29 years)","Identify mutation prevalence in GJB2, SLC26A4, mtDNA12SrRNA in profound NSHL","GJB2; SLC26A4","c.109G>A; c.1174A>T","AR","SNP scan assay","Profound","NA","NA"]
["https://doi.org/10.3390/ijms18112246","Ah Reum Kim, et al. (2017_","Korea","Hearing loss","Targeted resequencing",88,"NA/31","Assess pathogenicity of TMPRSS3 p.[V116M; V291L] allele in Koreans","TMPRSS3","P.V116M and P.V291L ","AR","Sanger Sequencing","Early-onset, progressive, severe-to-profound postlingual","NA","NA"]
["https://doi.org/10.1089/gtmb.2016.0051","Chen, S. et al. 2016","China","Hearing loss","Targeted sequencing",116,"Both/NA","To determine the genetic epidemiology of hearing loss in Chinese population","GJB2, SLC26A4, GJB3,MTRNR1, PCDH15, and TECTA","c.235delC, c.299delAT, c.109G>A; c.919-2A>G","AR","next generation sequencing","Severe to profound hearing loss","NA","NA"]
["https://doi.org/10.1038/srep34425","Wang, H. et al. (2017)","China","Hearing loss","Family based study",32,"Both/NA","To identify novel dominant GJB2 mutation in Chinese family","GJB2","c.524C > A (p.P175H)","AD","Polymerase chain reaction, sanger sequencing, next generation sequencing","Progressive, high frequency, congenital","Vestibular assessment via caloric test and cVEMP; results were normal.","NA"]
["https://doi.org/10.1016/j.bjorl.2017.10.013","Felix, F. et al. (2017)","Brazil ","SNHL","Observational study",100,"Both/(mean: 14.8 years)","To identify GJB2 variants beyond 35delG in multiethnic Brazilians","GJB2","p.[(Gly12Valfs*2)];[(Trp172*)], p.[(Gly12Valfs*2)](;)[(Met34Thr)], and p.[(Gly12Valfs*2)(;)[(Ser199Glnfs*9)])","AR","DNA sequencing","congenital, severe or profound, progressive","NA","NA"]
["https://doi.org/10.1186/s13023-017-0708-z","Yamamoto, N. et al. (2017)","Japan","SNHL","Prescreened cohort study",67,"Both/NA","To determine prevalence of TECTA mutations in MFSNHL","TECTA - DVD","p.R1890C, p.C633*, c.65-3C>T, p.Y1900C, p.S2017P","AD and AR","Sanger sequencing","Non-progressive, mid frequency","NA","NA"]
["https://doi.org/10.1371/journal.pone.0185281","Tlili, A. et al. (2017)","United Arab Emirates","Hearing loss","Mutation review study","50 +120","Both/NA","To identify novel ILDR1 mutation, review genotype–phenotype correlations","ILDR1","c.804delG","AR","Whole Exome Sequencing","Severe to profofund, low frequency","NA","NA"]
["https://doi.org/10.1016/j.ijporl.2017.06.008","Niu, Z. et al. 2017","China","SNHL","Family based study","9+286","Both/NA","To identify the genetic cause of SNHL in large family","WFS1 - DVD"," c.2591A > G ","AD","Array screening, whole-exome sequencing","Progressive, severe to profound","Vestibular function tested via HRCT, MRI, and vestibular exams; no dysfunction detected","NA"]
["https://doi.org/10.1038/s41598-017-08236-y","Lin, Yin-Hung, et al. (2017)","Taiwan","Hearing loss","Targeted screening panel",5,"Both/NA","To identify caussaative mutation in one family","POU4F3","p.Lys328Glu","AD","Massively parallel sequencing","Progressive","NA","NA"]
["https://doi.org/10.1371/journal.pone.0177636","Kitano, T. et al. (2017)","Japan","Hearing loss","Large cohort study",{"v":2549,"d":"2,549"},"Both/NA","To estimate the prevalece and phenotype of variants in Japan","POU4F3","p.Leu223Pro, p.Leu289Phe","AD","Massively parallel DNA sequencing","mid and high frequency, progressive","Vestibular function assessed using caloric testing and cVEMP; some patients showed unilateral dysfunction.","Vertigo/dizziness"]
["https://doi.org/10.1080/00016489.2016.1249946","Parzefall, T. et al. (2017)","Austria ","SNHL","Association study","11 NSHL patients with 30 controls","Both/NA","To test role of alternative transcription (exon 1a) in NSHL","GJB2","c.-2410T > C, rs7994748, NM_004004.5:c.-23 + 792T > C","AR","Genome-wide screening ","congenital, mild to profound","NA","NA"]
["https://doi.org/10.1186/s12881-017-0396-5","Huang, B. et al. (2017)","China","Hearing loss","Family based genetic study",8,"Both/NA","To identify causative mutation underlying progressive hearing loss in family","KCNQ4 - DVD","c.887G > A (p.G296D)","AD","Next generation sequencing","Postlingual, progressive","NA","NA"]
["https://doi.org/10.1016/j.amjoto.2024.104573","Deng, L. et al. (2025)","China","Enlarged Vestibular aqueduct (EVA)","Retrospective cohort",48,"Both/0.33 years","To assess hearing trajectories and build prediction model for progressive HL","SLC26A4","c.919-2 A > G","AR","Whole coding exon sequencing","Progressive, and high-frequency","Vestibular function assessed with CT/MRI imaging; no direct vestibular physiological tests reported.","Enlarged Vestibular Aqueduct (EVA)"]
["https://doi.org/10.1038/s41439-019-0075-5","Ito, T. et al. (2019)","Japan","Hearing loss","Case-control study",84,"Both/ (mean: 40 years)","To validate ddPCR for STRC CNV detection and estimate prevalence in Japanese patients","STRC","copy number variant","AR","Droplet Digital Polymerase Chain Reaction","mild-to-moderate ","NA","NA"]
["https://doi.org/10.1186/s40246-023-00556-7","Peart, L. et al. (2023)","South Florida","SNHL","Retrospective chart review",54,"Both/NA","To assess genetic causes of SNHL across diverse racial/ethnic groups","GJB2, MYO7A, SLC26A4, STRC","c.533G>C","AR, AD, and XL","Next-generation sequencing (NGS) ","mild to moderate, severe to profound","NA","NA"]
["https://doi.org/10.1167/iovs.64.10.23","Stephenson, Kirk A J. et al. (2023)","Island of Ireland","Usher syndrome ","Retrospective cohort study",145,"Both/(mean onset: 26.6 years)","To clinical/genetic characterization of Irish USH patients","ADGRV1, ARSG, CDH23, MYO7A, and USH2A","USH2A c.2299delG, c.8981G>A; MYO7A c.2904G>T, c.631A>G","AR","254 IRD-associated gene target capture sequencing panel, USH2A exon, and whole genome sequencing.","congenital, profound, mild to moderate, progressive","Vestibular assessment noted as subtype feature; limited quantitative vestibular data collected.","Dysfunction in USH1, progressive in USH3"]
["https://doi.org/10.1001/jamaoto.2022.4463","Carlson, Ryan J. et al. (2023)","United States","Childhood-onset hearing loss","Cross-sectional genomic study",406,"Both/NA","To identify genetic causes of SNHL, describe progression, and link genotype to cochlear implant (CI) outcomes","GJB2, STRC, SLC26A4, MYO15A, TMPRSS3","Copy number variants","AR","Next-generation sequencing (NGS) ","Severe to profound, high frequency, low frequency, mild to moderate","Vestibular imaging included enlarged vestibular aqueduct assessment via CT/MRI in some children","Enlarged Vestibular Aqueduct (EVA)"]
["https://doi.org/10.1007/s13353-021-00674-9","Lin, K. et al. (2022)","China","Congenital sensorineural hearing impairment; microtia","Genetic study","2 families","NA","To identify common molecular mechanisms between CSHL and microtia","EYA1","rs7095154 C>T, rs34736387 delTT","AD","Whole-exon sequencing (WES), Sanger sequencing, qPCR, and bioinformatics analyses","severe","Audiological exams included OAE, ABR, ASSR; temporal bone CT assessed ear malformations","NA"]
["https://doi.org/10.1007/s00439-021-02424-7","Thorpe, Ryan K. et al. (2022)","United states of America, China, Netherlands, Japan, Iran, Austria and others","Hearing loss","Retrospective analysis",2175,"NA","To refine the natural history for 4 of these genes","KCNQ4, GSDME, WFS1, and COCH","Splice and missense variants","AD","Variants curated via Deafness Variation Database & ACMG classification","High frequency, low frequency, profound","NA","NA"]
["https://doi.org/10.1177/01945998211029544","Ahmadmehrabi, S. et al. (2022)","United States of America","SNHL","Genomic association study",{"v":16657,"d":"16,657"},"Both/NA","To assess rare variants (MAF <5%) in 42 autosomal dominant (DFNA) postlingual HL genes","DIABLO, PTPRQ, TJP2, and POU4F3","Rare variants, predicted deleterious","AD","Exome sequencing","Postlingual","NA","NA"]
["https://doi.org/10.1016/j.ijporl.2021.110975","Nakano, A. et al. (2022)","Japan","Bilateral enlarged vestibular aqueducts","Retrospective study",28,"Both/Median age at first visit: 1.5 years","To define clinical course (screening performance, fluctuation/progression, vertigo) and genetic spectrum in bilateral EVA","SLC26A4","c.1544+1G > T and c.1614+5G > A","AR","Splice-site sequencing","Fluctuating, progressive","Clinical history of vertigo attacks; no dedicated vestibular function tests reported","Vertigo attack"]
["https://doi.org/10.1016/j.ejmg.2021.104311","Guan, J. et al. (2021)","China","Bilateral hearing loss","Family trio-based genomic study",404,"Both/NA","To define genetic causes and inheritance in sporadic bilateral HL","GJB2, SLC26A4, USH2A, MYO15A, OTOF","Rare, De novo, CNV variants","AR","Whole exome sequencing","Prelingual, severe to profound","NA","NA"]
["https://doi.org/10.1186/s12881-018-0630-9","Su, Y. et al. (2018)","China","Hearing loss","Family based study","3 probands; extended family members tested","Both/NA","To identify POU3F4 mutations, link to DFNX2 phenotype","POU3F4","c.973delT (p.Trp325Glyfs12), c.927delCTC (p.Ser310del), c.669T>A (p.Tyr223)","XLR","Targeted Sanger Sequencing","Congenital, severe to profound, progressive","NA","NA"]
["https://doi.org/10.1002/mgg3.394","Wang, H. et al. (2018)","China","Hearing loss","Genomic study","5 families","Both/NA ","To identify TMC1 variants; refine genotype–phenotype correlations","TMC1","c.1253T>A (p.M418K)","AD","High-throughput sequencing","Progressive, postlingual, all frequencies","NA","NA"]
["https://doi.org/10.1016/j.ijporl.2017.07.042","Aimoni, C. et al. (2017)","Italy","Enlarged vestibular aqueduct ","Retrospective clinical genetic study",14,"Both/NA","To describe audiologic & genetic features vs SLC26A4 status","SLC26A4","Pathogenic mutations","AR","Sequencing","Severe to profound","Caloric Fitzgerald-Hallpike test performed only in patients with vertigo history.","Vertigo"]
["https://doi.org/10.1007/s00467-016-3573-4","Martine T P Besouw et al. (2017)","United Kingdom","Hearing loss","Retrospective cohort",24,"NA","Long-term clinical and genetic characterization; genotype–phenotype links","ATP6V1B1, ATP6V0A4, SLC4A1","ATP6V1B1: c.905G>C (p.Arg302Pro)†, c.490_499del (p.Ile164Alafs*8); ATP6V0A4: c.1312_1315del (p.Asp438Metfs13)†, c.970del (p.Glu324Argfs22)†, c.1238G>A (p.Gly413Asp)","AR and AD","Targeted sequencing","Early onset, progressive, moderate to severe","NA","NA"]
["https://doi.org/10.1038/jhg.2017.42","Elena A Bliznetz. Et al. (2017)","Russia","Bilateral SNHL","Genetic/Epidemiological study",2569,"NA","To update GJB2/DFNB1 mutation spectrum in Russia; evaluate del(GJB2-D13S175) frequency & origin","GJB2","del(GJB2-D13S175)","AR","Exon sequencing","Profound, moderate","NA","NA"]
["https://doi.org/10.5582/bst.2017.01070","Du, Y. et al. (2017)","Beijing","SNHL","Retrospective genotype-phenotype analysis",582,"Both/NA","To analyze genotypes and phenotypes of deafness gene mutations in Chinese newborns.","GJB2, GJB3, SLC26A4","GJB2: c.235delC, c.299delAT, c.176del16, c.35delG; SLC26A4: c.IVS7-2A>G, c.2168A>G.","AR","Sanger Sequencing","High frequency","NA","NA"]
["10.1007/s00405-016-3954-0","Koichiro Wasano (2016)","Japan","MYH9 disorder","family study or case series study",9,"Both (10)","The primary objective was to characterise the auditory and other phenotypes of patients with MYH9 disorder. The study aimed to describe in detail the features of hearing loss in the examined family"," MYH9","c.4270G >A","AD","peripheral blood - PCR amplified and directly sequenced using an ABI 310 Genetic Analyzer and an ABI Prism Big Dye Terminator Cycle Sequencing kit","Progressive, and high-frequency","NA","NA"]
["10.1371/journal.pone.0165680","Kim (2016)","South Korea","progressive postlingual sensorineural hearing loss (SNHL), specifically nonsyndromic SNHL (NS-SNHL)","screening adult probands with postlingual NS-SNHL, which included a genetic epidemiological approach to investigate the contribution of CDH23",32,"Both (28)","The main objective was to demonstrate the significant contribution of CDH23 mutations to postlingual nonsyndromic SNHL in Koreans","CDH23","c.C719T , c.G5747A, c.G6604A, c.C1205T, c.C4762T, c.C5138A","AR","Whole Exome Sequencing, Sanger sequencing for verification of candidate variants, GJB2 sequencing, ","postlingual, progressive","NA","NA"]
["10.1590/1678-4685-GMB-2015-0218","Liu, Y. et al. (2016)","Mongolia","idiopathic sensorineural hearing impairment (SNHI)","The study involved a comprehensive genetic examination and haplotype analyses in a cohort of unrelated Mongolian families with idiopathic SNHI",188,"Both (<40)","The main objective was to unravel the unique spectra of deafness-associated mutations in Mongolians and to provide insights into the genetic relationships among Eurasian populations","GJB2, SLC26A4, and MT-RNR1 (mitochondrial 12S rRNA gene)","c.35delG, c.235delC, c.-23+1G>A (also referred to as c.IVS1+1G>A), c.109G>A, c.299_300delAT, c.35dupG, c.560_605dup, c.269T>C, and c.508_511dupAACG SLC26A4 mutations: c.919-2A>G, p.H723R, c.281C>T, and c.2027T>A MT-RNR1 mutation: m.1555A>G","AR","Sanger sequencing, Real-time PCR","idiopathic bilateral","NA"," Enlarged vestibular aqueduct (EVA) "]
["10.2147/TACG.S113828","Anastasia M Fedick (2016)","America , Ashkenazi Jewish population","nonsyndromic sensorineural hearing loss (SNHL), auditory neuropathy/dys-synchrony (ANSD)","The study involved the identification of a novel pathogenic variant in a large Ashkenazi Jewish family, followed by segregation analysis. Family study","Family : 11  ,  Carrier frequency study: 1,021 samples from self-identified Ashkenazi Jews","Both ( siblings at the time of genetic testing were: male, 5 years (proband II.8); female, 9 years (sibling II.6); female, 11 years (sibling II.5); and male, 3 years (sibling II.9)","The main objective was the identification of a novel pathogenic OTOF variant that causes nonsyndromic hearing loss with high frequency in the Ashkenazi Jewish population","OTOF","OTOF NM_194248.2 c.5332G>T, p.Val1778Phe","AR","Harvard OtoGenome testing panel, PCR and Sanger sequencing, Allelic discrimination assay (TaqMan) ","mild-to-moderate progressive","NA","The paper mentions that otoferlin plays a role in type 1 vestibular hair cells that are involved in sensing head acceleration and maintaining balance"]
["10.1089/omi.2016.0067","Caroça, C. et al. (2016)","São Tomé and Príncipe (field recruitment); Portugal (Nova Medical School / University of Lisbon for analyses)","Nonsyndromic sensorineural hearing loss (NSSHL); role of DFNB1 locus (GJB2/GJB6)","Cross-sectional case–control study","316 total: 136 NSSHL patients (92 bilateral, 44 unilateral) + 180 controls","2–35 years; no significant differences between patients and controls (p>0.2); both sexes","Investigate the contribution of the DFNB1 locus (GJB2 and GJB6) to nonsyndromic sensorineural hearing loss in São Tomé and Príncipe","GJB2 (Connexin 26) and GJB6 (Connexin 30) deletions del(GJB6-D13S1830) and del(GJB6-D13S1854)","Eight heterozygous coding variants in patients/controls: c.35delG (p.Gly12Valfs), c.101T>C (p.Met34Thr), c.109G>A (p.Val37Ile), c.186C>T (p.Asn62=), c.225G>T (p.Arg75=), c.380G>A (p.Arg127His), c.457G>A (p.Val153Ile), c.499G>A (p.Val167Met). Noncoding: ten variants including c.*84T>C (allele frequency ~24–30%), c.-22-12C>T, c.-15C>T, c.*104A>T, c.*111C>T.","AR","Guthrie card DNA extraction; PCR and Sanger sequencing of GJB2 coding region; multiplex PCR for GJB6 deletions; analysis with Chromas Lite + NCBI BLAST; Hardy–Weinberg testing; chi-square/Fisher statistics; WHO hearing loss classification applied","Mild to profound NSSHL; 92 bilateral, 44 unilateral. WHO classification used (threshold >25 dB across 0.5, 1, 2, 4 kHz). Pure tone audiometry or ABR performed depending on patient age/cooperation. Some variants (notably c.*84T>C noncoding) showed different genotypic distribution in severe/profound bilateral HL cases (p=0.005). Mild (26–40 dB), moderate (41–60 dB), severe (61–80 dB), profound (≥81 dB); majority bilateral moderate-to-severe.","Not performed.","na"]
["10.1590/2359-3997000000108","Chunyun Fu (2016)","China","Congenital Hypothyroidism (CH) and Pendred Syndrome (PS)","A mutation screening study of the SLC26A4 gene",192,"101 females and 91 males","The main objective was to examine the SLC26A4 mutation spectrum and prevalence among congenital hypothyroidism (CH) patients in the Guangxi Zhuang Autonomous Region of China and to establish how frequently PS causes hearing impairment in CH patients","SLC26A4 gene","p.P469S, p.V233L, p.M147I, p.V609G, and p.D661E","AR","Next-generation sequencing (NGS) ","sensorineural hearing loss","Not performed.","Enlarged Vestibular Aqueduct (EVA)"]
["10.1016/j.ijporl.2016.02.024","Chen (2016)","China","Nonsyndromic hearing loss (NSHL) and hereditary hearing loss (HHL)","A study comparing GJB2 variants in infants with NSHL and normal infants","300 infants with NSHL and 484 normal infants","Both (Infants aged 0–3 months)"," To clarify the possible roles of p.V27I and p.E114G variants of GJB2 in Chinese infants with NSHL","GJB2","p.V27I and p.E114G variants","AR","DNA extraction from whole blood, PCR of GJB2 exon 2, and sequencing using ABI PRISM BigDye Terminator Cycle Sequencing Kit and ABI 3730 DNA Automatic Sequencer","mild and moderate","NA","NA"]
["10.1007/s00405-015-3684-8","Mahdieh(2015)","Iran (specifically Ilam, Western Iran)","Nonsyndromic autosomal recessive deafness/hearing loss (ARNSHL)","A study investigating GJB2 mutations in 62 unrelated patients from 62 consanguineous families with nonsyndromic autosomal recessive deafness","62 unrelated patients with nonsyndromic autosomal recessive deafness from 62 families","Both ","To investigate and report the frequencies of GJB2 mutations among deaf subjects in Ilam, Iran, for the first time"," GJB2","35delG, R32H, W24X, and R127H","AR"," Amplification Refractory Mutation System (ARMS) for 35delG screening, followed by direct bidirectional Sanger sequencing of the GJB2 gene","severe-to-profound","High-resolution CT or MRI of temporal bone assessed inner ear anomalies","NA"]
["10.1007/s00405-015-3661-2","Choi (2015)","Korea","Sensorineural hearing loss (SNHL), specifically non-syndromic (DFNA10) ","Recruitment of 14 families with autosomal dominant moderate SNHL, followed by targeted exome sequencing of probands and confirmation via Sanger sequencing and co-segregation analysis in identified families","14 probands from 14 families, and 4 members from the identified family (SH117), with 592 normal control chromosomes used for comparison","Participants included both sexes in the broader study, but the specifically detailed affected family members were female (33, 58, and 50 years old), with no median age for the overall sample provided","To identify the frequency of EYA4 mutations in autosomal dominant moderate SNHL in a Korean population, report a novel EYA4 truncation mutation, and confirm a previously proposed genotype–phenotype correlation related to the gene","EYA4 and 134 known deafness genes","c.1194delT","AD","Targeted exome sequencing (TES-134) and Sanger sequencing","Progressive, postlingual, moderate, initially affecting mid-frequencies and progressing to all frequencies","Vestibular dysfunction excluded by clinical history; no vestibular symptoms reported in affected individuals","NA"]
["10.1016/j.ijporl.2016.01.001","Ma et al., 2016","China","Autosomal recessive sensorineural hearing loss (DFNB2)","Targeted capture of 127 known deafness genes and next-generation sequencing, followed by Sanger sequencing for variant confirmation and co-segregation analysis within the family and with ethnicity-matched controls","A Chinese family with 4 members (2 affected siblings, 2 unaffected parents) and 120 ethnicity-matched normal hearing controls","Both male and female participants; affected siblings were male (12 years old) and female (7 years old), and unaffected parents were male (40 years old) and female (39 years old)","To investigate mutations among a Chinese family with autosomal recessive hearing loss and identify the genetic causes, specifically novel compound heterozygous mutations in the MYO7A gene","MYO7A gene, and broadly 127 known deafness genes, including a pre-screening for GJB2, SLC26A4, and mtDNA 12S rRNA","A novel missense mutation c.3671C > A (p.A1224D) and a reported insert mutation c.390_391insC (p.P131PfsX9) in the MYO7A gene","AR","Targeted gene capture, next-generation sequencing, and Sanger sequencing","Congenital, symmetrical bilateral, and profound affecting all frequencies","Vestibular evaluation used Romberg and tandem gait tests; results were normal","NA"]
["10.1007/s10048-016-0477-1","Imtiaz, A. et al. (2016)","Pakistan, USA","Moderate to severe nonsyndromic hearing loss associated with TMC1 mutations","Family-based study recruiting six large consanguineous families, followed by STR (short tandem repeats) marker analysis, massively parallel sequencing, and Sanger sequencing for variant identification and co-segregation","Six consanguineous families (five of which segregated TMC1 mutations) and 150 ethnicity-matched normal-hearing individuals for variant frequency evaluation","Participants included both male and female individuals, with ages of affected individuals ranging from 7 to 23 years","To identify homozygous recessive mutations in TMC1 causing variable moderate-to-severe or moderate-to-profound hearing loss in six Pakistani families, report novel TMC1 mutations, and propose that hypo-functional TMC1 activity may lead to less severe hearing loss than typically reported","TMC1 and broadly known deafness genes, including a pre-screening for GJB2","Two reported homozygous mutations (p.R34X and p.R389Q) and three novel homozygous mutations (p.S596R, p.N199I, and c.1404+1G>T, a splice site variant causing exon 16 skipping) in the TMC1 gene","AR","parallel sequencing, targeted resequencing using a custom-designed SureSelect capture library, Sanger sequencing, and cDNA sequencing to analyze splice variants","Congenital, variable moderate-to-severe or moderate-to-profound","NA","NA"]
["10.3892/mmr.2016.4871","Lin, X. et al. (2016)","China ","Sudden sensorineural hearing loss (SSHL)","Case-control study","190 patients with SSHL and 210 healthy controls, totalling 400 participants","Both male (108 SSHL, 115 control) and female (82 SSHL, 95 control) participants were included. The average age for the SSHL group was 38.5±4.8 years, and for the control group, it was 38.9±5.3 years","To investigate the association between GRHL2 genetic polymorphisms and susceptibility to SSHL in a Chinese population, with the aim of elucidating its aetiology and providing clinical diagnostic tools","Grainyhead-like 2 (GRHL2)","GRHL2 rs611419, rs10955255, and rs6989650","NS","Polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) was used to detect GRHL2 genotypes from genomic DNA isolated from peripheral blood. This involved DNA extraction, purity detection by UV spectrophotometer, PCR amplification, agarose gel electrophoresis, digestion with shrimp alkaline phosphatase and ExoI, and identification using an ABI Prism 3130xl Genetic Analyzer","Generally in one ear","NA","NA"]
["10.1186/s12863-016-0354-9","Mikstiene, V. et al. (2016)","Lithuania","Congenital hearing loss (CHL), specifically early-onset non-syndromic sensorineural hearing loss","Cross-sectional study","158 affected participants (146 unrelated probands) with early-onset non-syndromic HL and 98 self-reported healthy Lithuanian inhabitants (unrelated adults)","Affected group: 77 female and 81 male. All children were aged under five at onset. Healthy group: 49 female and 49 male. Participants were \"unrelated adult individuals\"","To assess the contribution of the DFNB1 locus (GJB2 and GJB6 genes) in the development of early onset hearing loss, determine the population-specific mutational profile, and assess DFNB1-related HL burden in the Lithuanian population","GJB2 (connexin 26) and GJB6 (connexin 30) genes, located in the DFNB1 locus","GJB2 gene mutations: c.35delG (p.(Gly12Valfs2), rs80338939), c.313_326del14 (p.(Lys105Glyfs5), rs111033253), c.269 T > C (p.(Leu90Pro), rs8033894), c.101 T > C (p.(Met34Thr), rs35887622), c.167delT (p.(Leu56Argfs26), rs80338942), c.109G > A (p.(Val37Ile), rs72474224), c.379C > T (p.(Arg127Cys), rs727503066), and a novel truncating mutation c.206delT (p.Phe69Serfs13)","AR","For affected participants: Polymerase chain reactions (PCR) of coding sequences and flanking splicing sites of GJB2 and GJB6 genes, followed by capillary electrophoresis sequencing, For healthy participants: Next-generation exome sequencing after in-solution capture enrichment with an average 40-fold coverage, performed with a 5500 SOLiD™ Sequencer","mild, moderate, severe, or profound","Vestibular assessment not performed; study focused on GJB2/GJB6 mutations and genotype–phenotype correlation","NA"]
["10.1186/s12863-016-0333-1","Yuan, Y. et al. (2016)","China","Autosomal dominant nonsyndromic hearing impairment (ADNSHI) / sensorineural hearing loss (specifically related to the DFNA20/26 locus)","A study of a three-generation Chinese family with ADNSHI","A three-generation family with eight affected individuals and five unaffected members, totalling 13 family members","Both (12 to 69 years)","To identify the genetic cause of autosomal dominant nonsyndromic hearing impairment (ADNSHI) in a Chinese family and investigate its phenotypic heterogeneity, particularly the role of digenic mutations","ACTG1 and GJB2 genes were the primary focus after screening 129 known deafness genes","ACTG1: c.638A > G (p.K213R), a novel mutation found in all affected family members. GJB2: c.109G > A (p.V37I), found as homozygous in one affected individual (III:2) and heterozygous in his parents","AR, AD, Digenic","Targeted next-generation sequencing (NGS). Whole Exome Sequencing (WES). Sanger sequencing","Progressive, bilateral, sensorineural hearing loss","NA","NA"]
["10.1016/j.gene.2015.06.038","Dai, Z. et al. (2015)","China","Non-syndromic sensorineural hearing loss (NSHL)","A retrospective case series with correlation analysis of clinical phenotypes and genotypes","1481 NSHL patients","Both(11)","To analyze the characteristics and relationships of clinical phenotypes and genotypes of GJB2 in patients with non-syndromic hearing loss in China, with a specific focus on c.109GNA and c.79GNA + 341ANG mutations","GJB2 gene","c.235delC, c.109GNA, c.299delAT, c.176del16bp, c.79GNA + 341ANG, and other less common pathogenic mutations","AR","PCR procedure followed by sequencing (implied Sanger sequencing) of the GJB2 CDS region, with sequence alignment and annotation using GeneTool software","Severe","Vestibular assessment not reported; study focused on genotype–phenotype correlations in GJB2-related NSHL","NA"]
["10.1002/ajmg.a.37206","Gao, X. et al. (2015)","China","Autosomal dominant nonsyndromic hearing loss (ADNSHL), specifically progressive, postlingual forms","Characterization of a six-generation Chinese family, combining targeted gene capture, next-generation sequencing, bioinformatic analysis, and screening for prevalence in other ADNSHL families and controls","Three Chinese families identified with the TMC1 c.1714G>A mutation, a cohort of 67 ADNSHL families screened, and 308 normal controls. Forty-eight members from the primary family (Family 5315) participated, with 20 affected","Both ","To identify the causative gene for ADNSHL in a Chinese family, characterize the clinical and genetic features, and determine the prevalence and origin of the identified TMC1 c.1714G>A mutation in the Chinese population","TMC1 (Transmembrane Channel-Like Gene 1)","TMC1 c.1714G>A (p.D572N) missense mutation","AD","Targeted gene capture, massively parallel sequencing (next-generation sequencing - NGS) on Illumina HiSeq2000, Sanger sequencing (direct sequencing), digestion reactions (RFLP), and haplotype analysis using STR markers","Progressive, postlingual","Vestibular function evaluated with Romberg and tandem gait tests; no abnormalities found","NA"]
["10.1016/j.ajhg.2015.07.014","Tanaka, AJ. et al. (2015)"," twelve are of  European descent and two are Hispanic.  Research institutions involved are primarily in the USA (New York, Gaithersburg, Iowa City, New Orleans, Little Rock, Baltimore, Philadelphia) and The Netherlands (Utrecht)","A clinical syndrome characterized by microcephaly, intellectual disability (ID), seizures, sensorineural hearing loss, developmental delay, hypotonia, spasticity, and cortical visual impairment, associated with mutations in SPATA5","Whole-exome sequencing (WES) was used to identify genes in 14 individuals from ten independent families","14 affected individuals from ten independent families. Initial clinical WES was performed on 3,359 individuals with developmental delay, ID, or seizures","Both male and female participants were included. The children ranged in age from 2 to 19 years","To identify and characterize a clinical syndrome caused by autosomal-recessive pathogenic variants in SPATA5, presenting with severe neurological impairment including microcephaly, intellectual disability, generalized intractable epilepsy, abnormal muscle tone, and sensorineural hearing loss","SPATA5 (spermatogenesis-associated protein 5)","c.251G>A (p.Arg84Gln), c.556C>T (p.Arg186*), c.989_991del (p.Thr330del), c.1343C>T (p.Ser448Leu), c.1883A>G (p.Asp628Gly), and c.1714+1G>A (splice variant)","AR","Whole-exome sequencing (WES)","Congenital and bilateral","NA","NA"]
["10.1007/s00405-014-3171-7","Zeinali, S. et al. (2014)","Iran","Autosomal recessive non-syndromic sensorineural hearing loss (ARNSHL)","Development and use of an ARMS-PCR strategy for specific GJB2 mutations, combined with direct sequencing of exon 2 of the GJB2 gene","A total of 418 Iranian individuals with hearing loss","Both ","To develop a rapid and cost-effective ARMS-PCR strategy for the detection of the c.-23+1G>A mutation in GJB2 among Iranian deaf individuals, given its prevalence, and to determine the frequency of common GJB2 mutations in this population","GJB2","The main variants focused on were c.35delG and c.-23+1G>A (IVS1+1G>A)","AR","ARMS-PCR (Amplification-refractory mutation system-Polymerase Chain Reaction) for detecting c.35delG and c.-23+1G>A mutations. Direct sequencing of exon 2 of the GJB2 gene for mutation analysis of the coding region. Sanger sequencing was used to confirm ARMS-PCR results","NA","NA","NA"]
["10.5152/iao.2015.1212","Bozdoğan, ST. et al. (2015)","Turkey","Non-syndromic autosomal recessive congenital hearing loss; bilateral severe sensorineural non-syndromic hearing loss (NSHL)\n","Observational study investigating the prevalence and distribution of mutations in a patient cohort\n","77 patients\n","Male and Female. 45 males, 32 females. Mean age: 12.7 years (range, 1-16 years).\n","To evaluate the GJB2 gene in patients with hearing loss in their region using DNA sequencing and to demonstrate region-specific mutation and polymorphism distribution.\n","GJB2 (Gap junction protein beta 2)\n","Most frequent: 35delG (30.8% of mutant alleles) and V27I (23.1% of mutant alleles). Other mutations: E114G, IVS1-1G>A, Val153Ile, delE120, R184P (all 7.7% each), and T123N (3.9%). A polymorphism rs3751385:C>T was also common (87% of patients). Various genotypes observed, including homozygous 35delG, delE120, R184P, IVS1+1G>A, and heterozygous combinations like V27I / E114G.\n","Autosomal recessive ","Genomic DNA isolation from peripheral blood samples, PCR amplification of GJB2 gene exon1 and exon 2 regions, followed by DNA sequence analysis (SeqFinder Sequencing System; ABI 3130; Foster City, CA, USA) and analysis using SeqScape software.","Congenital, bilateral, severe sensorineural hearing loss (over 95 dB), non-syndromic.","NA","NA"]
["10.1016/j.ijporl.2015.06.009","Pang, X. et al. (2015)","China","Non-syndromic enlarged vestibular aqueduct (EVA) and associated hearing impairment (DFNB4)","A case-control study involving sequencing of SLC26A4 in probands and allele-specific PCR-based array screening in controls, with statistical analysis","150 Chinese Han deaf probands with non-syndromic EVA and 3056 ethnically-matched normal hearing controls","Both","To evaluate whether the presence of mono-allelic mutations of SLC26A4 in non-syndromic EVA patients is etiologically associated with the disorder","SLC26A4","Primarily focused on c.919-2A>G and p.H723R","AR","PCR amplification and sequencing of exons and flanking introns for probands, allele-specific PCR-based array for controls, and Sanger sequencing for verification","Permanent hearing impairment","Vestibular function inferred radiologically via EVA diagnosis; no functional vestibular testing described","Enlarged vestibular aqueduct (EVA)"]
["10.1007/s00438-015-0995-9","Chakchouk, I. et al. (2015)","Tunisia and Turkey","Autosomal recessive non-syndromic hearing loss (ARNSHL), specifically DFNB53"," Whole exome sequencing of two consanguineous families, followed by Sanger sequencing for validation, microsatellite genome-wide scan, PCR-RFLP genotyping for controls, bioinformatics analysis, and three-dimensional structural modeling of the protein","Two families (16 individuals from Tunisian family FT3, 2 affected siblings from Turkish family 262) and control groups (113 unrelated healthy Tunisian individuals, and 178 unrelated Turkish individuals from an exome database)","Both","To identify and confirm that novel COL11A2 mutations are responsible for autosomal recessive non-syndromic hearing loss (DFNB53) in two consanguineous families from Tunisia and Turkey, and to broaden the mutation spectrum and shed light on genotype-phenotype correlations","COL11A2","Two novel COL11A2 mutations: c.109G > T (p.Ala37Ser) in family FT3 and c.2662C > A (p.Pro888Thr) in family 262","AR","Whole exome sequencing (WES), Sanger sequencing for validation, microsatellite genome-wide scan, PCR-RFLP genotyping, and three-dimensional structural modeling of the NC4 domain of COL11A2","all frequencies, age-related progressive sensorineural HL after age 30, moderate ","Vestibular examinations performed; no abnormalities reported in affected or carrier individuals","NA"]
["10.1007/s00405-014-2970-1","Martines, F. et al. (2014)","Italy","Non-syndromic sensorineural hearing loss (SNHL), specifically associated with GJB2 biallelic mutations","A descriptive and correlational study investigating genotype distribution and correlation with audiological profiles in Sicilian patients with biallelic GJB2 mutations. It involved molecular analysis and audiological evaluation","A total of 73 Sicilian patients","Both","To study the genotype distribution of Sicilian patients with biallelic GJB2 mutations, to correlate genotype classes and/or specific mutations of GJB2 with audiological profiles, and to study the distribution of specific GJB2 mutations across provinces of origin","GJB2, GJB6","GJB2 mutations: 35delg, IVS1+1 (IVS1+1G>A), 167delt, L90P, M34t, D179H, R184P, Δ104, E47X, Δ103.   GJB6 deletions: del(GJB6-D13S1830) and del(GJB6-D13S1854)","AR","PCR, direct sequencing","Bilateral SNHL","NA","NA"]
["10.1038/jhg.2015.19","Sun, Y. et al. (2015)","China","Autosomal dominant middle-frequency sensorineural hearing loss (MFSNHL)","A family-based genetic study, using targeted exome sequencing of an affected individual, followed by Sanger sequencing for validation and co-segregation analysis in a large Chinese family","44 family members (18 affected, 26 unaffected) from a 6-generation pedigree, and 100 unrelated normal Chinese control DNA samples","Both ","To analyse and explore the clinical audiological characteristics and identify the causative gene of non-syndromic autosomal dominant inherited MFSNHL in a Chinese family","The targeted exome sequencing used a deafness disease-related Gene Panel designed to tile along 102 deafness system disease-related genes, 3 miRNA, and 3 Mitochondrial genes","A novel heterozygous missense mutation c.1643C>G in exon 18 of EYA4, causing the amino-acid substitution p.T548R (Threonine to Arginine) at a conserved position","AD","Targeted exome sequencing, Sanger sequencing","Late onset, progressive, bilateral, mid-frequency","Vestibular assessment by questionnaires, otoscopy, audiometry, immittance, DPOAE, ABR; no vestibular abnormalities reported","NA"]
["10.1016/j.gene.2015.02.022","Frykholm, C. et al. (2015)","Sweden","Autosomal dominant nonsyndromic sensorineural hearing impairment (ADNSHI) / DFNA10","A family-based genetic study using genome-wide linkage analysis, followed by sequencing of candidate genes and co-segregation analysis within a large seven-generation family, along with extensive clinical and audiometric data analyses","32 individuals from generations IV–VII were included for DNA extraction and questionnaires, with 25 individuals participating in genome-wide linkage analysis, and 24 mutation-positive individuals for clinical data assessment. The pedigree traced 93 affected individuals across seven generations","Both","To identify the genetic cause of autosomal dominant hearing impairment in a Swedish family, investigate the phenotypic variability (especially the variable age of onset), and determine if a novel EYA4 frameshift mutation in the variable region of the protein is associated with dilated cardiomyopathy, contrasting previous findings","Prior to this, mutations in GJB2, TECTA, GRHL2, GJB6, GJB3, GJA1, SLC26A4, SLC26A5, 12S rRNA, and tRNA-Ser had been excluded","A novel heterozygous frameshift mutation c.579_580insTACC in exon 8 of EYA4, predicted to result in p.(Asp194Tyrfs*52)","The identified mutation was heterozygous.","Genome-wide linkage analysis, Sanger sequencing, segregation analysis, APEX microarray, RT-PCR analysis ","Postlingual-onset, progressive sensorineural hearing impairment. Audiometric configurations were variable, showing either mid- and/or high-frequency hearing loss.","NA","NA"]
["10.1186/s13023-015-0276-z","Mizutari, K. et al. (2015)","Japan","Autosomal recessive non-syndromic hearing loss (DFNB12) and Usher syndrome type 1D (USH1D), specifically focusing on patients with congenital high-frequency sporadic or recessively inherited hearing loss","A study to determine the prevalence of CDH23 mutations in patients with specific clinical characteristics, involving direct sequencing of CDH23 after pre-screening for common deafness genes and rigorous clinical selection","87 probands were selected for CDH23 mutation analysis from a total of 1167 probands screened. In these 87 probands, 16 probands were identified with homozygous or compound heterozygous pathogenic CDH23 mutations.  In total, 56 subjects from 28 families had pathogenic mutations","Both","To reveal the prevalence of CDH23 mutations among patients with congenital high-frequency sporadic or recessively inherited hearing loss and to expand the CDH23 mutation spectrum","Primarily CDH23. They also excluded patients with GJB2 mutations and mitochondrial m.1555A > G and m.3243A > G mutations before CDH23 analysis","CDH23 mutations, including five novel mutations. These mutations comprised 12 missense, two frameshift, and two splice-site mutations.  The most frequent mutation was p.P240L","Sporadic or recessively inherited hearing loss. The identified pathogenic mutations were found as homozygous or compound heterozygous","Direct sequencing","Bilateral non-syndromic congenital hearing loss, with a poorer hearing level at high frequencies (e.g., 2 kHz, 4 kHz) than at low frequencies (e.g., 250 kHz, 500 Hz), and severe or profound hearing loss (over 70 dB) at frequencies exceeding 2 kHz","NA","NA"]
["10.1186/s12967-015-0483-3","Huang (2015)","China","Postlingual, progressive, autosomal dominant nonsyndromic hearing loss (ADNSHL) at the DFNA10 locus","A genetic study of a five-generation family using targeted next-generation sequencing (NGS) to screen 130 known deafness genes, with confirmation of the candidate mutation by Sanger sequencing","A five-generation family was studied, with 15 individuals (8 affected, 7 unaffected) participating in the genetic analysis.  The candidate mutation was also screened in 1000 unrelated controls with normal hearing","Both (20 to 40 years)","To identify the genetic cause of autosomal dominant hearing loss in a Chinese family using NGS and to analyse the genotype-phenotype correlation, particularly the differences in age of onset and audiogram shapes compared to previous reports on EYA4 mutations","The study also screened for common deafness genes including GJB2, SLC26A4, and mitochondrial 12S rRNA as an initial step","A novel heterozygous insertion mutation c.544_545insA in exon 8 of EYA4, leading to a frameshift and a premature stop codon, p.F221X","AD","Targeted next-generation sequencing (NGS), Sanger sequencing","Postlingual, bilateral, symmetrical, progressive sensorineural hearing loss. ","NA","Vestibular dysfunction"]
["10.1177/0003489415575061","Mori (2015)","Japan"," Autosomal recessive nonsyndromic hearing impairment (DFNB25) caused by mutations in the GRXCR1 gene, which results in progressive sensorineural hearing loss (SNHL) and can be associated with dizziness"," A genetic screening study using targeted genomic enrichment with massively parallel sequencing (TGE+MPS) on a large cohort to identify the genetic causes of hearing loss","1120 Japanese hearing loss patients from unrelated families were enrolled in the study. From this cohort, one family with two affected individuals was identified with GRXCR1 mutations","Both ","To identify the genetic cause of progressive hearing loss in a Japanese family using massively parallel sequencing and to describe the clinical features of patients with novel GRXCR1 mutations","GRXCR1 was the gene where causative mutations were identified. The screening method involved a panel of 63 known nonsyndromic hearing loss genes.","Two novel compound heterozygous mutations in GRXCR1: c.439C>T (p.R147C) and c.784C>T (p.R262X).","The affected individuals were found to have compound heterozygous mutations.","Targeted genomic enrichment, massively parallel sequencing (MPS), Sanger sequencing","Progressive, bilateral sensorineural hearing loss.","Caloric testing revealed bilateral canal paralysis; patients also reported dizziness without true vertigo","Occasional dizziness, bilateral canal paralysis"]
["10.1177/0003489415575057","Miyagawa(2015)","Japan"," Autosomal dominant sensorineural hearing loss (ADSNHL), specifically the DFNA20/26 locus","A genetic screening study using targeted massively parallel DNA sequencing (MPS) to analyse 63 deafness genes in a large patient cohort, followed by Sanger sequencing for confirmation","1120 Japanese hearing loss patients (probands) were screened, from which 5 families were identified with ACTG1 mutations. A total of 14 affected patients from these 5 families were clinically described.","Both ","To clarify the mutational spectrum, detailed clinical features, and genotype-phenotype correlations for patients with hearing loss caused by mutations in the ACTG1 gene.","The primary gene of interest was ACTG1. The screening method involved a targeted panel of 63 known deafness genes.","A total of 4 different missense mutations were identified in 5 families: c.142G>C (p.G48R), c.353A>T (p.K118M), c.721G>A (p.E241K), and c.895C>G (p.L299V).","AD"," Massively parallel DNA sequencing (MPS), Sanger sequencing","Progressive, symmetrical sensorineural hearing loss that typically begins in the high frequencies and later progresses to involve all frequencies.","Vestibular testing, including caloric test and cVEMP, performed; results normal in tested patient","Vertigo in one patient"]
["10.1177/0003489415575056","Miyagawa (2015)","Japan","Autosomal recessive nonsyndromic hearing loss (DFNB8/10) caused by mutations in the TMPRSS3 gene, which typically results in postlingual, progressive, high-frequency hearing loss.","A genetic screening study using targeted massively parallel DNA sequencing (MPS) to analyse 63 deafness genes in a large cohort of hearing loss patients. ","A total of 1120 Japanese hearing loss patients were screened. From this cohort, 5 patients from 4 families were identified with TMPRSS3 mutations and their clinical features were analysed. ","Both","To clarify the frequency of TMPRSS3 mutations in the Japanese hearing loss population, describe the detailed clinical characteristics of affected patients, and discuss the optimal intervention, specifically the use of electric acoustic stimulation (EAS).","The primary gene of interest was TMPRSS3.   The screening panel included a total of 63 deafness genes. ","Four novel mutations (p.F71S, p.G94R, p.H130R, p.T205fs) and three previously reported mutations (p.Q76X, p.R216L, p.A260T) were identified. ","AR"," Massively parallel DNA sequencing (MPS), Sanger sequencing","Progressive, symmetrical, postlingual sensorineural hearing loss. ","Vestibular function assessed by caloric testing and cVEMP; all patients showed normal results","NA"]
["10.1111/cge.12437","Chaussenot A (2014)","France","A wide spectrum of WFS1-related disorders, primarily Wolfram syndrome (WS) and autosomal dominant low-frequency sensorineural hearing loss (LFSNHL), including uncommon phenotypes like late-onset WS and dominant deafness with optic atrophy"," A cohort study providing a clinical and molecular update on 96 French patients, including 37 newly reported individuals, with WFS1-related disorders","A total of 96 patients from 75 families were included in the cohort. ","Both","To update the clinical and molecular data for a French cohort of patients with WFS1-related disorders, describe uncommon phenotypes, and determine the frequency of large-scale rearrangements in the WFS1 gene."," The primary gene sequenced was WFS1. The CISD2 gene was also sequenced in some patients to rule out Wolfram syndrome 2. ","15 novel deleterious putative mutations were identified, including one large deletion of 17,444 base pairs. A wide variety of missense, frameshift, and stop mutations were analysed.","AR, and AD","Sanger sequencing, quantitative PCR (qPCR), and array-CGH","The hearing profile was variable depending on the specific disorder and included low-frequency sensorineural hearing loss (LFSNHL) and high-frequency hearing impairment, often associated with optic atrophy or diabetes. ","Vestibular function not systematically assessed; some patients reported balance disorders or ataxia","Minor anterior labyrinth abnormality in one patient"]
["10.1371/journal.pone.0124232","Mašindová (2015)","Slovakia and Hungary, Czech Republic, and the United States, focusing on Central European populations","Autosomal recessive nonsyndromic sensorineural hearing loss (SNHL) at the DFNB49 locus, caused by mutations in the MARVELD2 gene within the Roma population","A genetic prevalence and haplotype analysis study in a cohort of hearing-impaired Roma individuals from Slovakia and Hungary, with comparative analysis of samples from the Czech Republic and Pakistan","143 hearing-impaired Slovak Roma patients and 85 hearing-impaired Hungarian Roma patients were screened. Control groups included 702 normal-hearing Roma individuals and 375 hearing-impaired Slovak Caucasians. Haplotype analysis included patients from the Czech Republic and Pakistan.  ","Sex not mentioned. The age of the Slovak patients with confirmed mutations ranged from 6 to 23 years","To establish the prevalence and clinical impact of MARVELD2 mutations in the deaf Roma population from Slovakia and Hungary and to analyse a possible common origin of the c.1331+2T>C mutation among Roma and Pakistani carriers","The primary gene of interest was MARVELD2. The study included patients who were pre-screened as negative for biallelic GJB2/GJB6 mutations. ","The main variant was the pathogenic splice-site mutation c.1331+2T>C. Another variant of unknown pathogenicity, c.950G>A (p.Arg317Gln), was also identified. ","Autosomal recessive, The study identified 12 new patients who were homozygous for the c.1331+2T>C mutation. ","Direct (Sanger) sequencing, Restriction Fragment Length Polymorphism (RFLP) analysis, haplotype analysis","Prelingual, non-progressive, bilateral, moderate to profound sensorineural hearing loss, with a downsloping audiometric curve in most individuals","NA","NA"]
["10.1007/s00439-015-1532-y","Nayak(2015)"," The study was a multi-national collaboration involving researchers and families from Pakistan, Slovakia, and the USA.","Autosomal recessive nonsyndromic hearing loss (DFNB49) caused by pathogenic mutations in the MARVELD2 gene"," A molecular genetics study combining mutation screening, clinical re-evaluation, and in-vitro functional analysis to define the spectrum of MARVELD2 mutations and associated clinical phenotypes in families from Pakistan and Slovakia.","The study cohort comprised 800 families from Pakistan with recessive deafness, from which 12 DFNB49 families were identified.  Comprehensive clinical evaluation was performed on members of one Pakistani family (PKDF1069) and one Slovak Roma family.","The study included both males and females. The ages of the affected individuals who underwent detailed clinical evaluation ranged from 6 to 22 years.","To determine the types and frequencies of MARVELD2 mutations in a large Pakistani cohort and to perform comprehensive clinical evaluations on Pakistani and Slovak families to see if hearing loss is part of a wider syndrome, as suggested by mouse models","To determine the types and frequencies of MARVELD2 mutations in a large Pakistani cohort and to perform comprehensive clinical evaluations on Pakistani and Slovak families to see if hearing loss is part of a wider syndrome, as suggested by mouse models","The primary gene of interest was MARVELD2","The study identified a novel large deletion of exons 4 and 5, as well as two previously reported splice junction variants, c.1331+2T>C and c.1183−1G>A","Sanger sequencing, long-range PCR, microsatellite marker genotyping ","Prelingual, moderate to profound, bilateral sensorineural hearing loss","Vestibular function assessed by tandem gait and Romberg testing; all patients showed normal results","NA"]
["10.1038/jhg.2014.114","Wang (2015)","China","Autosomal dominant nonsyndromic hearing loss (ADNSHL) DFNA4B in a Chinese family","A genetic study of a single large family, combining genome-wide linkage analysis and whole-exome sequencing to identify the causative mutation","A five-generation family (SY-026) was investigated, with 34 members participating in the study. An additional 200 unrelated control subjects were also included","The study included both males and females. The paper does not state a median age, but the ages of participants at the time of testing ranged from 3 to 72 years.","To identify the pathogenic mutation causing ADNSHL in a large Chinese family using a combined strategy of linkage analysis and exome sequencing","CEACAM16 was identified as the causative gene.  Mutations in GJB2, GJB3, EYA4, KCNQ4, and MYH14 were excluded.","A novel heterozygous missense mutation, c.505G>A (p.G169R), in exon 3 of the CEACAM16 gene","AD","Whole-exome sequencing, and Sanger sequencing, genome-wide SNP linkage analysis","Bilateral, postlingual, progressive sensorineural hearing loss. It typically began with decreased hearing at higher frequencies in the first or second decade and progressed to profound hearing loss across all frequencies. A common symptom was high-frequency tinnitus.","Vestibular function tested by videonystagmography, including caloric and positional tests; results showed no dysfunction","NA"]
["10.1371/journal.pone.0116931","Kim(2015)","Korea and Japan. Focusing on a Korean family","Autosomal recessive nonsyndromic sensorineural hearing loss (SNHL), DFNB42, caused by mutations in the ILDR1 gene"," A genetic study of a single multiplex family using whole-exome sequencing to identify the causative mutation, followed by in-vitro functional analysis and protein modelling to assess its pathogenicity","A three-generation Korean family (SNUH23) was studied, with five members participating in the genetic analysis. A control group of 476 chromosomes from unrelated Korean normal hearing individuals was also used.","Both","To identify the novel ILDR1 mutation causing a milder auditory phenotype ('partial deafness') in a Korean family and to investigate the pathogenic mechanism through functional and structural protein modelling.","The primary gene of interest was ILDR1. The TMPRSS3 gene was also sequenced and excluded as a cause.","A novel homozygous missense variant, c.C206A (p.P69H), in the ILDR1 gene was identified.","AR","Whole-exome sequencing (WES), Sanger sequencing, three-dimensional (3D) protein modelling with molecular dynamics simulations","Post-lingual, progressive, downsloping high-frequency hearing loss ('partial deafness' or 'ski-slope' type), with preservation of low-frequency hearing.","NA","NA"]
["10.3109/14992027.2014.944276","Yazdanpanahi(2014)","Iran","Autosomal recessive hearing loss, specifically non-syndromic hearing loss (DFNB4) and Pendred syndrome (PS), caused by mutations in the SLC26A4 gene","121 Iranian families were included, which consisted of 61 unrelated multiplex families and 60 unrelated deaf patients. For pathogenicity investigation, 100 ethnically matched hearing controls were also recruited.","A total of 12 different mutations were identified, including frameshift deletions/insertions (e.g., c.2106delG, c.65-66insT), missense mutations (e.g., c.1226G>A, c.1238A>G), and a splice site mutation (c.919-2A>G)","Both","To determine the prevalence, types, and spectrum of SLC26A4 mutations and the associated clinical phenotypes in a large series of Iranian deaf patients with autosomal recessive hearing loss","The primary gene investigated was SLC26A4. The study included families who were previously found to be negative for GJB2 mutations","A total of 12 different mutations were identified, including frameshift deletions/insertions (e.g., c.2106delG, c.65-66insT), missense mutations (e.g., c.1226G>A, c.1238A>G), and a splice site mutation (c.919-2A>G)","AR"," Linkage analysis using Short Tandem Repeat (STR) markers, Sanger sequencing","The hearing loss was congenital and ranged from moderate to profound sensorineural hearing loss","Temporal bone CT scans assessed vestibular aqueduct enlargement in mutation-positive families","Enlarged Vestibular Aqueduct (EVA)"]
["10.1111/cge.12332","Vona(2015)","Germany","Autosomal recessive non-syndromic hearing loss (NSHL), specifically DFNB16, and its syndromic form, deafness-infertility syndrome (DIS)","A genetic diagnostic study to determine the frequency and types of mutations in the STRC gene in individuals with hearing loss who were negative for GJB2/GJB6 mutations","94 individuals with non-syndromic hearing loss (NSHL) and one patient with syndromic SNHL. A control group of 100 normally hearing adults was also used","Both ","To implement and validate a routine diagnostic strategy for STRC mutation analysis, including a Sanger sequencing method that excludes a highly similar pseudogene, to determine the contribution of STRC mutations to congenital hearing impairment","STRC (stereocilin) and its closely linked pseudogene pSTRC. The cohort was pre-screened to be negative for mutations in GJB2 and GJB6.CATSPER2 deletions were also noted in cases of Deafness-Infertility Syndrome","The study looked for homozygous and heterozygous deletions (copy number variations), as well as smaller mutations such as point mutations and small intragenic deletions/duplications. They specifically investigated the c.3893A>G variant but concluded it was likely non-pathogenic","AR","Microarray, quantitative polymerase chain reaction (qPCR), Sanger sequencing method using long-range PCR","Mild to moderate hearing impairment, often with a sloping high-frequency audiometric profile","NA","NA"]
["10.1016/j.jns.2015.04.038","Ahmed et al., 2015","Saudi Arabia","Perrault Syndrome type-3 (PRLTS3)","Case report with homozygosity mapping and exome sequencing","One consanguineous family (8 members)","Affected: 1 male (12y), 1 female (8y)","To identify the molecular cause of PRLTS3 in a Saudi family and expand its clinical spectrum .","CLPP, HSD17B4","CLPP: c.685T>G (p.Tyr229Asp)","AR","Microarray, whole-exome sequencing, Sanger sequencing","Profound sensory neuronal hearing loss in early childhood","NA","NA"]
["10.1089/gtmb.2014.0241","Qing et al., 2015","Southwestern China","Severe or profound sensorineural hearing loss (SNHL)","Cross-sectional genetic screening study","1,164 children","658 males; Average age 4.5 ± 1.3 years","To study the distribution of common deafness gene mutations in children in southwestern China.","GJB2, SLC26A4, mtDNA, GJB3, TRMU","Various GJB2 variants (e.g., c.235delC); SLC26A4: c.IVS7-2A>G, c.2168A>G; mtDNA: m.1555A>G, m.1494C>T; GJB3: c.538C>T","AR and mtDNA","Microarrays, Sanger sequencing","Severe to profound SNHL (>70 dB)","High-resolution CT/MRI assessed vestibular aqueduct enlargement and inner ear malformations","NA"]
["10.1159/000366514","Kim et al., 2015","South Korea","Nonsyndromic sensorineural hearing loss (NSHL)","Case series with targeted resequencing and bioinformatics analysis","Two families","Not specified","To report novel TECTA mutations and propose a new genotype-phenotype correlation .","TECTA and 133 other known deafness genes","TECTA: c.3995G>T (p.C1332F), c.5618C>T (p.T1873I)","AD","Targeted resequencing, Sanger sequencing","Stable, moderate SNHL; one family with high-frequency, one with mid-frequency loss","NA","NA"]
["10.1089/gtmb.2014.0185","Stanghellini et al., 2014","Italy, with patients from Belgium and Algeria","Nonsyndromic sensorineural hearing impairment (HI)","Retrospective study","498 patients","Not specified","To report new and rare GJB2 variants and establish genotype/auditory phenotype correlations.","GJB2, GJB6","Eight rare GJB2 variants including W3R, I20T, V95M, N206S, C218Y, K221N, c.-22-6T>C, c.-22-2A>C","Compound heterozygous/simple heterozygous","Direct sequencing","Mild to profound hearing impairment","NA","NA"]
["10.1002/ajmg.a.36760","Bai et al., 2014","China","All-frequency sensorineural hearing loss","Case study using exome sequencing","One six-generation family","Not specified","To investigate the genetic cause of all-frequency hearing loss in a Chinese family .","WFS1 and 10 other candidate genes","WFS1: c.2389G>A (p.D797N)","AD","Exome sequencing, Sanger sequencing, and PCR-RFLP","Symmetrical, severe-to-profound, non-syndromic sensorineural hearing loss in all frequencies .","Vestibular testing performed; no abnormalities detected in utricle, saccule, or balance assessments","NA"]
["10.1089/omi.2014.0063","Bosch et al., 2014","Cameroon and South Africa","Nonsyndromic deafness","Cross-sectional genetic screening with bioinformatic analysis","205 patients and 81 controls","Not specified","To ascertain the significance of GJB2 mutations in Cameroonian and South African deaf patients .","GJB2","p.F142del and p.V167M","AR","Sanger sequencing, bioinformatic analysis","Sensorineural or mixed hearing loss","NA","NA"]
["10.3109/00016489.2014.927588","Xu et al., 2014","China (Gansu Province)","Nonsyndromic sensorineural hearing loss (NSHL)","Cross-sectional study investigating prevalence of mutations in different ethnic groups","155 Dongxiang, 17 Bonan, 12 Yugur, and 464 Han ethnic group patients","Both","Determine the prevalence of GJB2 and SLC26A4 genes and mtDNA1555A>G mutations and analyze the ethnic specificity in the NSHL of unique ethnic groups in Gansu Province.","GJB2, SLC26A4, mtDNA1555A>G","GJB2: c.299_300delAT, c.235delC, c.35delG, c.257C>G, c.176-191del16, etc. SLC26A4: IVS7-2A>G, c.2168A>G, c.2162C>T, new variants c.918+48A>G and c.2090-51insAAAC. mtDNA1555A>G","homozygous or compound heterozygous mutations identified","Genomic DNA from peripheral blood leukocytes, PCR amplification, bidirectional sequencing (or enzyme digestion for mtDNA1555A>G)","Moderately severe to profound NSHL","NA","NA"]
["10.1002/lary.24697","Javidnia et al., 2014","Uganda","Nonsyndromic sensorineural hearing loss","Observational study","126 subjects","63 males, 63 females","To determine the prevalence of connexin 26 and 30 mutations in hearing-impaired patients from Uganda .","GJB2, GJB6","c.208C>G (p.Pro70Ala) in GJB2","AR","Sanger sequencing, multiplex PCR","Bilateral, severe-to-profound SNHL","NA","NA"]
["10.1371/journal.pone.0103133","Wang et al., 2014","China","Autosomal dominant non-syndromic hearing loss (ADNSHL)","Case study with targeted high-throughput sequencing","Two large families (30 probands in initial cohort)","Not specified","To identify pathogenic KCNQ4 mutations in two large Chinese families with ADNSHL .","KCNQ4 and 29 other ADNSHL genes","KCNQ4: p.W275R (novel), p.G285S (known)","AD","Targeted high-throughput sequencing, Sanger sequencing","Post-lingual, progressive, high-frequency involved SNHL","Vestibular symptoms were assessed clinically; no vestibular signs reported in affected family members","NA"]
["10.1007/s12041-014-0365-0","Neocleaus et al., 2014","Cyprus","Sensorineural nonsyndromic hearing loss (NSHL)","Observational study screening for mutations in a cohort","146 unrelated subjects of Greek Cypriot origin","Not specified","Report the spectrum of GJB2 mutations in Cypriots with sensorineural nonsyndromic hearing loss compatible with recessive inheritance","GJB2 (also GJB6 deletions screened)","GJB2: c.35delG (81.7%), p.Arg184Pro, p.Leu90Pro, p.Glu47stop, delGlu120, c.167delT, p.Val178Ala, p.Val153Ile (controversial pathogenicity), p.Val37Ile, c.-23+1G>A, novel c.-1G>A 5'UTR. GJB6 deletions del(GJB6-D13S1830) and del(GJB6-D13S1854) screened but no pathogenic mutations found","Autosomal recessive (compatible with recessive inheritance of NSHL)","Genomic DNA isolation, PCR amplification of entire coding regions of GJB2 and GJB6. Allele-specific PCR for c.35delG. Multiplex PCR amplification for GJB6 deletions. Direct sequencing of GJB2 exon 1","Bilateral SNHL, severe to profound range","NA","NA"]
["10.3109/14992027.2014.905717","Salvago et al., 2014","Sicily (Italy)","Congenital non-syndromic sensorineural hearing loss (NSHL)","Retrospective study","102 patients","52 males, 50 females; Median age 11.5 years","To evaluate the frequency of GJB2 mutations and their phenotype correlation in Sicilian NSHL patients .","GJB2, GJB6","GJB2: c.35delG, c.167delT, c.-23+1G>A, and others","AR","Sequencing and PCR","Bilateral NSHL, mostly profound","NA","NA"]
["10.1111/cge.12247","Webb et al., 2014","USA (Ashkenazi Jewish population)","Alport syndrome","Case report with population screening","One family and 2017 controls","3 affected sisters","To determine the molecular basis of Alport syndrome in an Ashkenazi Jewish family and identify a founder mutation .","COL4A3, COL4A4, COL4A5","COL4A3: c.40_63del","AR","Linkage analysis, targeted next-generation sequencing, Sanger sequencing","Sensorineural hearing loss","NA","NA"]
["10.1016/j.ijporl.2014.03.033","Jin et al., 2014","South Korea","Nonsyndromic hearing loss/Auditory neuropathy (AN/AD)","Genetic screening and case series","71 probands (from initial cohort of 151)","Not specified","To describe the frequency of OTOF mutations in Koreans and report a vertical transmission of DFNB9 .","OTOF, PJVK, DIAPH3, GJB2","OTOF: p.Y374X, c.4799+1G>T, p.R1045GfsX28","AR","Direct PCR sequencing, targeted resequencing (TRS-80)","Nonsyndromic recessive or sporadic hearing loss; some with Auditory Neuropathy/Auditory Dys-synchrony (AN/AD) phenotype .","NA","NA"]
["10.1016/j.ijporl.2014.04.002","Loeza-Becerra et al., 2014","Mexico","Hereditary sensorineural hearing loss (SNHL)","Cross-sectional prevalence study","140 unrelated probands","76 males, 64 females; Age 1 month to 43 years","To analyze the prevalence of GJB2 and GJB6 mutations in different geographic areas of Mexico .","GJB2, GJB6, mt.1555A>G","GJB2: c.35delG, p.V84M, p.R32S (novel) and others; GJB6: DelGJB6-D13S1830","AR and AD","Direct sequencing, PCR","Prelingual SNHL, moderate to profound","NA","NA"]
["10.3892/mmr.2014.2148","Jiang et al., 2014","China (Zhejiang Province)","Autosomal recessive non-syndromic hearing loss (ARNHL)","Cross-sectional genetic screening study","176 unrelated pediatric patients","82 males, 94 females; Mean age 5 ± 2.7 years","To investigate the prevalence and spectrum of GJB2, SLC26A4, and GJB3 mutations in Zhejiang province, China .","GJB2, SLC26A4, GJB3","GJB2: c.235delC, c.176_191del16, c.299_300delAT, p.W44L (novel), p.D66N (novel); SLC26A4: IVS7-2A>G; GJB3: c.538C>T","AR","PCR sequencing and SNaPshot sequencing","Severe to profound bilateral SNHL","Vestibular function assessed by CT imaging of temporal bone to detect enlarged vestibular aqueduct","NA"]
["10.3109/00016489.2014.890740","Ishikawa et al., 2014","Japan","Nonsyndromic high-frequency SNHL","Family study with detailed audiological and vestibular examinations, and genetic analysis","5 members of a family (3 affected, 2 unaffected)","Male. I-2 (55 years old), II-2 (34 years old), III-1 (14 years old) are affected","Determine the responsible deafness gene in a Japanese family with dominantly inherited high-frequency SNHL of unknown etiology","KCNQ4, TECTA","c.211delC mutation in KCNQ4 gene; c.2967C>A (p.H989Q) mutation in TECTA gene. The KCNQ4 mutation was associated with high-frequency SNHL","Autosomal dominant","PCR amplification of all 14 exons of KCNQ4 and all 23 exons of TECTA, standard cycle sequencing reaction, computer analysis with wANNOVAR","High-frequency SNHL, progressive.","Vestibular function assessed with caloric testing and electronystagmography after cold-water ear irrigation","Two of the three affected subjects (II-2 and III-1) showed hyporeflexia in the right ear with recurrent vestibular symptoms. Subject I-2 showed normal response without vestibular symptoms"]
["10.1007/s00109-014-1128-3","Chung et al., 2014","South Korea","Autosomal recessive nonsyndromic hearing loss (arNSHL)","Prevalence study with protein modelling and functional assay","51 probands","Not specified","To reveal the genetic contribution of TMPRSS3 mutations in Koreans and correlate clinical phenotype with genotypes .","TMPRSS3, GJB2","TMPRSS3: p.A306T, p.T248M (novel)","AR","Sanger sequencing, targeted resequencing (TRS-80)","Postlingual, progressive, ski-slope hearing loss","NA","NA"]
["10.7717/peerj.384","Pique et al., 2014","USA","Sensorineural hearing loss (SNHL) with Pendred syndrome (PDS) or DFNB4","Multi-centre screening study","107 probands","Not applicable","To investigate the contribution of large SLC26A4 deletions/duplications and digenic inheritance with FOXI1 and KCNJ10 to SNHL .","SLC26A4, FOXI1, KCNJ10","SLC26A4: deletion of exons 4–6; FOXI1: p.Thr226Ile; KCNJ10: p.Arg271His, p.Arg271Cys","AR and possibly Digenic","MLPA, Sanger sequencing","Congenital sensorineural hearing loss","Vestibular dysfunction rarely reported; 1/54 noted symptoms, imaging showed EVA in subse","Vestibular dysfunction in one patient"]
["10.1097/MAO.0000000000000238","Chien et al., 2014","China (Northwest region)","Sensorineural hearing loss (SNHL), nonsyndromic hearing loss (NSHL)","Observational study investigating mutation spectrum among different ethnicities","2349 unrelated SNHL individuals (1835 Han Chinese, 306 Hui, 208 Uyghur). Control group: 655 normal hearing individuals","Male and Female. Han Chinese: mean age 13.6 ± 4.0 years. Hui: mean age 14.4 ± 4.3 years. Uyghur: mean age 13.8 ± 3.7 years","Investigate the mutation spectrum of GJB2, mitochondrial 12S rRNA, and SLC26A4 genes of Han Chinese, Hui people, and Uyghur ethnicities in SNHL patients in northwest of China","GJB2, mitochondrial 12S rRNA, SLC26A4\n","GJB2: c.235delC, c.299_300delAT, c.176_191del16, c.35delG. mtDNA 12S rRNA: A1555G. SLC26A4: c.919-2A>G (IVS7-2A>G), c.2168A>G (H723R), c.2162C>T, c.919-18T>G, c.920C>T, c.987A>G, c.2183A>G, c.1001+32A>G, c.1001+5G>C, c.2107C>G","Nonsyndromic HL (e.g., autosomal recessive, mitochondrial inheritance)","Genomic DNA isolation, PCR amplification, direct sequencing in ABI 3730 DNA Sequencer. Analysis with reference sequences in NCBI","Moderate to profound SNHL","Vestibular function assessed using rotational chair testing (sinusoidal harmonic acceleration, SHA)","SLC26A4 mutation is related to enlarged vestibular aqueduct (LVAS). HRCT scan of petrous temporal bone obtained for evaluation of LVAS."]
["10.1016/j.ijporl.2014.01.022","Bonyadi et al., 2014","Iran (Azeri Turkish ethnicity)","Autosomal recessive non-syndromic hearing loss (ARNSHL)","Genetic screening study","508 patients","249 males, 259 females; Mean age 22 years","To assess the spectrum and frequency of GJB2/GJB6 mutations in northwest Iran .","GJB2, GJB6","GJB2: c.35delG, IVS1+1G>A, delE120, and 27 others","AR and mtDNA","ARMS-PCR, SSCP, PCR-RFLP, sequencing","Prelingual ARNSHL","NA","NA"]
["10.1016/j.ijporl.2014.01.011","Chai et al., 2014","China","Non-syndromic sensorineural hearing loss (NSHL)","Large scale mutation screening study","619 probands (485 simplex, 134 multiplex)","Not specified","To investigate the co-existence of MT-RNR1 and bi-allelic GJB2 mutations in a large cohort .","GJB2, MT-RNR1","GJB2: p.V63L/p.M195V, c.235delC; MT-RNR1: m.1555A>G","AR","Bidirectional sequencing","Variable, from normal hearing to moderate or severe/profound NSHL","NA","NA"]
["10.3109/00016489.2013.849817","Du et al., 2014","China (Silk Road region)","Nonsyndromic hearing loss (HL) / sensorineural hearing loss","Observational study investigating prevalence and spectrum of mutations","2398 patients. Control group: 1057 normal hearing individuals","Male and Female. Mean age 13.75 ± 4.03 years (range 1.5 to 39 years)","Investigate the prevalence of GJB2 mutations in the Silk Road region of China to study the mutation spectrum in this area","GJB2\n","41 different variants of nucleotide sequence detected, 3 novel. Most common: c.235delC (70%). Novel: c.225G>T (p.R75R), c.521G>A (p.C174Y), c.557C>T (p.T186M)","Autosomal recessive nonsyndromic hearing loss (ARNSHL)","Genomic DNA extraction, PCR amplification, bidirectional sequencing by capillary electrophoresis. Data analyzed against NCBI reference","Severe or profound nonsyndromic HL and speech dysplasia.","NA","NA"]
["10.1371/journal.pone.0090688","Yoshimura et al., 2014","Japan","Usher syndrome type 1","Genetic screening using massively parallel DNA sequencing","17 unrelated patients","9 males, 8 females; Ages 9 to 64 years","To facilitate diagnosis of Usher Syndrome Type 1 patients using massively parallel DNA sequencing .","Nine USH genes, including MYO7A, CDH23, PCDH15","19 variants in MYO7A, CDH23, PCDH15 (14 novel)","AR","Massively parallel DNA sequencing (MPS) and direct sequence analysis","Profound hearing loss","Vestibular dysfunction in USH1 inferred clinically as absent vestibular responses; no formal vestibular testing","Absent vestibular responses"]
["10.1155/2014/746838","Du et al., 2014","China (Northwest: Gansu, Xinjiang, Ningxia, Qinghai, Shaanxi)","GATA3 mutation, HDR syndrome (Hypoparathyroidism, deafness, renal dysplasia)","Case series","6 patients","Male and Female. 3 males, 3 females. Age range 29-60 years, mean age 42.5 years","Report the auditory and vestibular phenotypes of patients with GATA3 mutation","GATA3\n","Heterozygous GATA3 mutations (specific variants not detailed)","Autosomal dominant (DFNA2)","Sanger sequencing confirmed heterozygous mutations","Early-onset SNHL during childhood, downsloping SNHL. Mean 3-frequency PTA 67 dBHL. Average word recognition score 73%. DPOAEs absent in all patients, ABRs remarkably robust (supporting outer hair cell dysfunction)","No dedicated vestibular function testing performed; HRCT of the petrous temporal bone was used to detect large vestibular aqueduct and other inner ear malformations associated with SLC26A4 mutations","Some patients complained of dizziness, but rotary chair testing (SHA) was normal across participants (4 of 6 patients). No evidence of abnormal horizontal semicircular canal function"]
["10.1159/000356681","Zhang et al., 2014","China","MYH9-related disease (MYH9RD)","Case report and mutation survey","One four-generation pedigree","Not specified","To describe a large Chinese pedigree with MYH9-related disease and survey reported mutations .","MYH9","MYH9: V1516L","AD","Direct sequencing","Hearing loss","NA","NA"]
["10.1159/000356303","Beelen et al., 2014 ","The Netherlands","HDR syndrome (hypoparathyroidism, deafness, renal defects)","Case series with extended audiological tests, psychophysical measurements, CT scanning, and vestibular testing","5 patients from 1 family (human study)","Both","Describe the audiometric characteristics of a Dutch family with a new mutation in GATA3 causing HDR syndrome and evaluate hearing impairment, cochlear anatomy, and vestibular function","GATA3\n","c523_528dup (p.Gln178ProfsX19)","Autosomal dominant","Genomic DNA isolation, PCR amplification of GATA3 coding exons, sequencing with Life Sciences 3130 sequencer, comparison with reference sequence (NM_001002296.1)","Congenital, bilateral, symmetric, mild-to-moderate sensorineural hearing impairment","Vestibulo-ocular examination performed; no vestibular anomalies detected despite reported symptoms","2 patients displayed vestibular symptoms (dizziness and instability)."]
["10.1111/cge.12074","Rendorff et al., 2013","Denmark/Scandinavia","Pendred syndrome (PDS) / DFNB4","Observational study investigating mutation frequency and spectrum","109 unrelated probands","Not specified","Report the first large study of a Scandinavian PDS/DFNB4 group by SLC26A4 sequencing and identify the mutation frequency and spectrum","SLC26A4 (also FOXI1, KCNJ10, and SIX1 screened)","29 different SLC26A4 mutations (9 novel). Most frequent: p.T416P, p.V138F, p.L236P, p.E29Q, c.1001+1G>A, and p.E384G. Also p.E125K de novo SIX1 mutation in one patient","Recessive (PDS/DFNB4)","SLC26A4 sequencing of all exons, SLC26A4 MLPA analysis, sequencing of FOXI1, KCNJ10, and SIX1. Microarray test (APEX) for 198 HI-associated mutations for some probands","Congenital/pre-lingual sensorineural hearing impairment (HI)","Vestibular dysfunction assessed indirectly via CT for EVA/Mondini dysplasia and perchlorate discharge testing","Variable vestibular dysfunction, temporal bone abnormalities (EVA or Mondini dysplasia)"]
["10.1001/jamaoto.2013.4185","Chattaraj et al., 2013","USA (NIH cohort)","Hearing loss with enlarged vestibular aqueduct (EVA), including Pendred syndrome (PS) and nonsyndromic EVA (DFNB4)","Prospective cross-sectional study","24 subjects with unilateral EVA (from a cohort of 116)","10 males, 14 females; Median age 7 years","To evaluate SLC26A4 mutation testing results in subjects with unilateral EVA .","SLC26A4","Various SLC26A4 variants, including p.F335L, IVS8+1G>A, p.R185T, c.890delC","AR","Sequencing","Hearing loss with unilateral EVA","CT/MRI temporal bone imaging used to assess vestibular aqueduct enlargement and malformations.","NA"]
["10.1016/j.ijporl.2013.06.015","Riah et al., 2013","Tunisia","Congenital autosomal recessive non-syndromic hearing loss (ARNSHL)","Case study of two unrelated non-consanguineous families","2 affected individuals from 2 families (DF55-III-1 and DF146-III-1). Parents were also screened as carriers","Both","To determine the molecular etiology of hearing loss in two Tunisian individuals and report a novel frameshift GJB2 mutation in two Tunisian families","GJB2\n","c.405delC (novel frameshift mutation resulting in p.Tyr136Thrfs*32) in compound heterozygosity with c.35delG. An intronic GJB2 polymorphism c.-34C>T (rs 9578260) was also detected in DF146-III-1.","Autosomal recessive, indicated by compound heterozygosity for the mutations and segregation pattern in families","Genomic DNA extraction from peripheral blood leukocytes, PCR amplification of the entire coding region of GJB2 gene and flanking acceptor splicing site, and direct sequencing.","Congenital, bilateral, profound, sensorineural hearing loss.","CT and MRI imaging used; no vestibular abnormalities detected in affected patients.","NA"]
["10.1016/j.ijporl.2013.06.017","Huang et al., 2014","Taiwan, China","Pendred syndrome","Case study of a Chinese patient and family, with comparison to 100 unrelated control subjects","1 proband (female) and her parents, compared with 100 unrelated control subjects","Female","To investigate mutations in the SLC26A4 gene in a Chinese patient with Pendred syndrome and identify a novel pathogenic mutation.","SLC26A4","c.1263+1G>A (IVS10+1G>A) (novel splice-site mutation) in compound heterozygosity with c.1079C>T (p.A360V)","Autosomal recessive (due to compound heterozygous mutations)","DNA extraction, PCR amplification of 20 coding exons of SLC26A4, automated DNA sequencing analysis, RFLP for mutation confirmation.","Congenital sensorineural deafness, often prelingual and profound with a fluctuating course. ","CT imaging revealed bilateral enlarged vestibular aqueducts; no additional vestibular testing reported.","Marked enlargement of bilateral vestibular aqueduct (>1.5 mm, with measurements of Right: 0.59 cm, left: 0.58 cm) found by CT of the temporal bone, compatible with large vestibular aqueduct syndrome."]
["10.1177/0194599813493075","Shahzad et al., 2013","Pakistan","Prelingual sensorineural hearing loss / Usher syndrome","Prospective genetic screening study","34 families (from a cohort of 243)","Not specified","To identify the genetic cause of hearing loss in Pakistani families using OtoSeq NGS platform .","MYO7A, CDH23, SLC26A4","MYO7A (22 variants, 11 novel), CDH23 (1 variant), SLC26A4 (1 variant)","AR","Short Tandem Repeat (STR) linkage analysis, OtoSeq (NGS platform), Sanger sequencing","Prelingual, severe-to-profound, recessive hearing loss","Vestibular function assessed by tandem gait and Romber testing in affected individuals\n","Impaired vestibular function"]
["10.1186/1471-2350-14-85","Landa et al., 2013","UK","Pendred syndrome/Enlarged vestibular aqueducts (EVA)","Genetic screening study","68 patients with monoallelic SLC26A4 mutations and 95 controls","Not specified","To investigate the association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations .","SLC26A4, KCNJ10, FOXI1","KCNJ10: p.Arg271Cys, p.Arg18Gln; FOXI1: p.Arg123Trp","AR and Digenic","PCR and Sanger sequencing","Sensorineural hearing impairment","Vestibular assessment based on clinical history, imaging (CT for EVA), no functional vestibular tests.","NA"]
["10.1007/s10528-013-9583-z","Bukhari et al., 2013","Pakistan (Hazara Division)","Nonsyndromic deafness","Genetic screening study","70 deaf participants and 50 controls","Not specified","To determine the prevalence of GJB2 mutations in individuals with hearing loss from the Hazara Division, Pakistan .","GJB2","GJB2: c.71G>A (p.W24X), c.104T>G (p.I35S), c.35delG","AR","Direct sequencing","Nonsyndromic deafness, moderate to profound","Vestibular function screened using Romberg and tandem gait tests in all participants.","NA"]
["10.1371/journal.pone.0070134","Li et al., 2013","China","DFNA8/12 (dominant deafness)","Case study with linkage and sequencing analysis","One three-generation family (18 members)","Not specified","To identify a novel TECTA mutation in a Chinese DFNA8/12 family .","TECTA","TECTA: p.A1982D","AD","Linkage analysis and direct sequencing","Prelingual, progressive, all-frequency sensorineural hearing impairment","Vestibular assessment relied on clinical history; only one member reported vertigo symptoms.","Vertigo reported by one patient"]
["10.1111/jcmm.12080","Gao et al., 2013","USA (California)","Sensorineural hearing loss (DFNA2, autosomal dominant nonsyndromic deafness)","In vitro study using HEK293T cells, immunofluorescent microscopy, Western blot, co-immunoprecipitation, whole-cell voltage clamp recording","N/A (in vitro study with cell lines)","N/A (in vitro study with cell lines)","Investigate molecular etiology of DFNA2 by examining decreased cell surface expression and impaired conductance of the KCNQ4 channel","KCNQ4\n","L274H, W276S, L281S, G285C, G285S, G296S, G321S (missense mutations), also inframe deletion c.664_681del mentioned","Autosomal dominant (DFNA2)","Constructs of mutant KCNQ4 channels generated from tagged WT constructs using QuikChange Lighting Site-Directed Mutagenesis Kit and verified by DNA sequencing","Progressive sensorineural hearing loss across all frequencies (general description of DFNA2)","NA","NA"]
["10.3109/14992027.2013.783719","Matos et al., 2013","Portugal","Nonsyndromic sensorineural hearing loss (NSSHL)","Comprehensive molecular analysis, audiological methods","264 Portuguese unrelated individuals (sporadic and familial cases)","Not explicitly stated","Assess the spectrum and prevalence of mutations in the GJB2 gene in Portuguese NSSHL patients","GJB2 (also GJB6 deletions screened)","21 different GJB2 variants (18 coding, 3 noncoding). Most frequent: c.35delG (15.9%). Novel: c.24G>A (p.T8T). GJB6 deletion del(GJB6-D13S1854) found in 2 patients","Recessive mode of inheritance predominantly observed in familial cases.","PCR-mediated site-directed mutagenesis (PSDM) and RFLP, Single-strand conformational polymorphism (SSCP), Direct sequencing of entire coding region and flanking acceptor splice site of GJB2. Multiplex PCR for GJB6 deletions","Bilateral mild to profound NSSHL.","NA","NA"]
["10.1186/1750-1172-8-85","Yang et al., 2013","China","Non-syndromic deafness","Genetic screening using targeted next-generation sequencing","90 total probands with NSSHL recruited; 36 had GJB2 mutations, 22 SLC26A4, 7 MT-RNR1 → 125 probands left for NGS (93 simplex, 24 multiplex with presumed recessive inheritance, 7 dominant, 1 maternal)","Mean 14.0 years (95% CI 11.8–16.3); range few months to >50 years; both sexes","Systematically assess the contribution of 79 less commonly screened deafness genes to non-syndromic deafness in Chinese Han patients using targeted NGS","79 targeted deafness genes (50 non-syndromic, 7 non-syndromic/syndromic, 22 syndromic), including MYO15A, USH2A, PCDH15, GPR98, TMC1, MYO6, TECTA, POU4F3, COCH, PTPRQ, CDH23, OTOF, MYO7A, ESRRB, MARVELD2, WHRN, MTTS1 (mitochondrial)","MYO6 c.2944C>T (p.Q982X, nonsense)\n• TECTA c.4525T>G (p.C1509G, missense, reported)\n• POU4F3 c.603_604delGG (frameshift)\n• COCH c.260G>T (p.G87V, missense)\n• MTTS1 T7511C (mitochondrial, maternally inherited); Identified in 15 genes for 28 probands (MYO15A, GPR98, TMC1, USH2A, PCDH15 most frequent ≥3 probands each; also CDH23, OTOF, MYO7A, ESRRB, MARVELD2, TECTA, WHRN, MYO6, PTPRQ, POU3F4). Many novel nonsense, frameshift, splicing and missense variants reported (48 novel mutations total).","• Autosomal dominant (4 families, MYO6/TECTA/POU4F3/COCH)\n• Mitochondrial (1 family, MTTS1)\n• Autosomal recessive (28 probands bi-allelic mutations in 15 genes)","Pre-screening GJB2, SLC26A4, MT-RNR1 by Sanger sequencing.\n• Targeted exon capture of 79 deafness genes (Roche NimbleGen capture array) followed by Illumina HiSeq2000 sequencing (average depth 293x, >99% coverage at ≥20 reads).\n• Variants filtered for rarity (≤0.25%), predicted impact and segregation analysis; validated by Sanger sequencing; in silico prediction with Mutation Taster, PROVEAN, SIFT, Human Splicing Finder.","• Severe-to-profound prelingual/early-onset SNHL in majority of probands\n• Late-onset progressive moderate-to-severe SNHL in seven dominant probands\n• PTA threshold >70 dB for early-onset and >40 dB by age 35 for late-onset probands\n• Audiometry, ABR, tympanometry and in some cases CT performed\nSeverity\tWHO classification: mild 20–40 dB, moderate 41–70 dB, severe 71–95 dB, profound >95 dB. Most were severe-profound.","Romberg and tandem gait tests assessed vestibular function in probands with suspected recessive inheritance.","na"]
["10.1097/MAO.0b013e31828d6501","Ramsebner et al., 2013","Austria and Spain","Nonsyndromic hearing impairment (NSHI)","Case-control genetic screening study","40 idiopathic NSHI patients, 32 c.35delG heterozygotes, 47 c.35delG homozygotes, and 211 controls","Not specified","To identify genetic changes in the regulatory region of GJB2 associated with NSHI .","GJB2","GJB2 regulatory region: rs117685390 C/T","AR, AD, mtDNA","Targeted next-generation sequencing and Sanger sequencing","Non-syndromic deafness, mostly severe-to-profound","NA","NA"]
["10.3174/ajnr.A3367","Elmaleh-Bergès et al., 2013","France, Belgium, Australia","Waardenburg syndrome (WS) types 2 and 4, and neurologic variants (PCWH)","Retrospective multicenter study","15 patients","Ages 8 days to 31 years","To evaluate the spectrum and frequencies of inner ear malformations in patients with Waardenburg syndrome and SOX10 mutations .","SOX10","Various SOX10 mutations","AR","Sanger sequencing and MLPA","Nonsyndromic hearing impairment","Auditory brainstem response, behavioral audiometry, and vestibular evaluation (Romberg, gait, caloric testing).","NA"]
["10.1186/1471-2350-14-56","Ganaha et al., 2013","Japan (Okinawa Islands)","Pendred syndrome (PS) or enlarged vestibular aqueduct (EVA) syndrome","Genetic screening and clinical correlation study","22 patients from 21 families","8 males, 14 females; Median age 8.5 years","To investigate SLC26A4 mutations and clinical manifestations in patients from the Okinawa Islands .","SLC26A4","SLC26A4: IVS15+5G>A and H723R","AD","Direct sequencing","Congenital sensorineural hearing loss (SNHL), mostly profound","CT of temporal bone; vestibular enlargement, EVA, and vertigo assessed via caloric testing/nystagmus.","Frequent vestibular malformations (agenesis/hypoplasia of SCCs)"]
["10.1371/journal.pone.0063231","Naito et al., 2013","Japan","Autosomal dominant nonsyndromic hearing loss (ADNSHL)","Comprehensive genetic screening and review","287 probands and 252 controls","Not specified","To determine prevalence, mutation spectrum, and genotype/phenotype correlations of KCNQ4 mutations in a large Japanese ADNSHL cohort .","KCNQ4","KCNQ4: c.211delC (founder), p.V230E, p.W276S, and 4 others","AR","Sequencing, qRT-PCR","Sensorineural hearing loss with EVA or PS","NA","Vertigo reported in some patients"]
["10.1016/j.amjoto.2012.11.002","Gallant et al., 2013","USA (Philadelphia, PA)","Autosomal dominant late onset sensorineural hearing impairment (BLSNHI) and tinnitus (DFNA9)","Case report of a three-generation family using genome-wide linkage approach and mutational analysis","17 members from an extended family (3 affected subjects); 49 ethnically matched unrelated controls","Male and Female. Proband (IV 10) 38 years old. Father (III 6) in his 20s. Sister (IV 12) 31 years old. Age of onset late teens/early 20s","Describe a three-generation family with late onset bilateral sensorineural hearing impairment and tinnitus in which a novel mutation in the COCH gene was identified","COCH","NM_001135058:c.1196_1213del (heterozygous 18 base pair deletion) resulting in p.Ile399_Ala404del (in-frame deletion of 6 amino acids) in exon 11","AD","Direct sequencing and haplotype analysis","All-frequency or high-frequency predominant SNHL, progressive","Medical history taken; no vestibular symptoms reported; no vestibular function tests performed.","NA"]
["10.1371/journal.pone.0061592","Kim et al., 2013","South Korea","Mild or moderate hearing loss","Genetic prevalence study with targeted NGS","103 families (from initial 201)","Not specified","To estimate the prevalence of the p.V37I variant of GJB2 in subjects with mild hearing loss and prove its pathogenic potential .","GJB2 and 81 other deafness genes","GJB2: p.V37I","AR","Bidirectional Sanger sequencing of both exons and flanking regions of GJB2; targeted NGS panel of 82 deafness genes in selected cases; multiplex breakpoint PCR for GJB6 deletions","ure-tone audiometry (0.5–4 kHz) or ABR/ASSR for young children; classified subtle (16–25 dB), mild (26–40 dB), moderate (41–70 dB), severe (71–95 dB), profound (>95 dB). p.V37I carriers mostly mild–moderate, with occasional progression","No formal vestibular testing reported. Vestibular status inferred from nonsyndromic classification and CT/MRI exclusion of inner ear anomalies; no objective balance or vestibular reflex testing performed","na"]
["10.1161/CIRCGENETICS.112.964684","Giudicessi et al., 2013","USA (Rochester, MN)","Long-QT syndrome (LQTS), Jervell and Lange-Nielsen syndrome (JLNS), autosomal recessive LQT1 (AR LQT1)","Retrospective analysis of LQTS patients from a referral clinic, genotype-phenotype correlation analysis combining with literature cases","249 KCNQ1-positive patients identified, 15 patients (6.0%) harbored mutations on both KCNQ1 alleles (11 AR LQT1, 4 JLNS).","Male and Female. For the 15 patients: 7 males, 8 females. Age at diagnosis 7.0 ± 9.5 years. Average age at evaluation for 249 KCNQ1-positive patients: 21 ± 16 years","Determine the prevalence and genetic determinants of sensorineural deafness in KCNQ1 homozygosity and compound heterozygosity, especially in cases without deafness (AR LQT1)","KCNQ1\n","Truncating (e.g., nonsense, frameshift, splice-site) and nontruncating (e.g., missense, in-frame deletion) mutations. Examples from Table 1: G179S, Q530X, G568R, H614del, L191fs/90, V524G, R174C, K362R, R518X, V576I, R594P, P320S, P448L, R259L, V215M, W392X, C122Y, M159sp, Y171X.","AR","Sanger sequencing, targeted next generation sequencing","Subtle, mild, or moderate hearing loss","na","NA"]
["10.1002/art.37810","Kuemmerle-Deschner et al., 2013","Germany","Muckle-Wells Syndrome (MWS)","Prospective observational cohort study","33 patients","16M/17F; Median age 35 years","To determine otologic characteristics and hearing loss trajectories in MWS .","NLRP3","NLRP3: T348M, A439V, E311K, V198M","AD","Standardized PCR and Sanger sequencing of exon 3 of NLRP3 to confirm mutation status in all patients.","Standardized pure-tone audiometry 250–10,000 Hz revealed bilateral high-frequency SNHL in 67% of patients; loss progressed with age, mutation-specific risk evident (T348M > E311K > A439V/V198M); 50% adults reported non-debilitating tinnitus","Comprehensive neuro-otologic testing consistening of Videonystagmography, Vertigo history, ","vestibular reactivity remained normal in all 15 patients tested."]
["10.1073/pnas.1222285110","Yan et al., 2013","China, USA, Australia, New Zealand","Progressive sensorineural hearing loss (DFNA41)","Genetic and functional study","Two families and P2RX2-null mice","Not specified","To identify the gene for DFNA41 and explore its role in progressive and noise-induced hearing loss .","P2RX2","P2RX2: c.178G>T (p.V60L)","AD","Gene sequencing","Progressive sensorineural hearing loss, starts at high frequencies","na","NA"]
["10.1002/humu.22232","Choi et al., 2013","South Korea","X-linked nonsyndromic hearing loss (DFNX2)","Research Article","6 families","Male/9.5 years","Investigate pathogenic mechanisms of novel POU3F4 mutations, including frameshift extensions.","POU3F4","POU3F4 mutations (p.Thr354GlnfsX115, p.Leu317PhefsX12, p.Gln229Arg, p.Thr211Met, p.X362ArgextX113)","XLR","Bidirectional nucleotide sequence analysis, Sanger sequencing","Moderate to profound","Medical and developmental history interviews and physical examinations included questions about balance, but no dedicated vestibular tests (vHIT, calorics, rotary chair) were reported.","NA"]
["10.1111/j.1399-0004.2012.01884.x","Husu et al., 2013","Denmark","CHARGE syndrome","Nationwide study","18 individuals","6 Males, 12 Females/8.3 years","Describe clinical characteristics and the phenotypic spectrum in Danish individuals with genetically verified CHARGE syndrome.","CHD7","CHD7 gene mutations/deletions (nonsense, frameshift, missense, splice site)","AD","Molecular testing, Sanger sequencing","Sensorineural hearing loss","Clinical signs: balance difficulties and delayed motor milestones (13/13; 100%) used as indicators of vestibular impairment.\nImaging: 3D MRI and CT of the temporal bone used to assess inner ear structures—absent/hypoplastic semicircular canals and dysplastic cochlea.\nNo formal vestibular laboratory tests (vHIT, calorics, rotary chair) reported.","Vestibular dysfunction 10/13 (77%) showed clinical vestibular dysfunction with balance delay.\nImaging confirmed absent/hypoplastic semicircular canals and dysplastic cochlea in the majority.\nStrong association between delayed motor milestones and vestibular anomalies."]
["10.4067/S0716-97602013000300003","Cifuentes et al., 2013","Chile","Non-syndromic deafness","Cross-sectional","113 patients","46 Males, 67 Females/Ages 2-39 years","Estimate the frequency of the c.35delG mutation in the GJB2 gene in two samples of deaf patients.","GJB2, GJB6","GJB2 c.35delG","AR","Allele-specific PCR, direct DNA Sanger sequencing","Profound to moderate sensorineural hearing loss","not reported","not assessed"]
["10.33549/physiolres.932475","Groh et al., 2013","Czech Republic","Hereditary hearing loss (DFNB1)","Case-control","156 subjects (34 heterozygotes, 122 controls)","13 Male, 21 Female heterozygotes/Not specified","Evaluate hearing function in heterozygous carriers of the GJB2 c.35delG mutation.","GJB2","GJB2 c.35delG","Heterozygous carriers","Allele-specific PCR, fluorescence PCR with fragment analysis","High-frequency hearing loss (8-16 kHz) in females","No vestibular functional testing performed; study assessed only auditory thresholds and otoacoustic emissions","NA"]
["10.1371/journal.pone.0057369","Wu et al., 2013","Taiwan","Idiopathic sensorineural hearing impairment (SNHI)","Case series","12 multiplex families","Not specified","Investigate the diagnostic utility of massively parallel sequencing in multiplex families with idiopathic SNHI.","GJB2, MYO7A, KCNQ4, MYH9, and GJB4","GJB2 p.R75Q, MYO7A p.T381M, KCNQ4 p.S680F, MYH9 p.E1256K","Idiopathic nonsyndromic SNHL, 10 families AD, 2 families AR","Massively parallel sequencing (MPS), Sanger sequencing","Variable: mild low-tone to profound progressive SNHI","Clinical exam + imaging only: all probands underwent high-resolution CT and/or MRI of temporal bones to exclude inner ear malformations.\nNo dedicated vestibular laboratory tests (vHIT, calorics, rotary chair) were reported.","NA"]
["10.1371/journal.pone.0055178","Sang et al., 2013","China","Autosomal dominant hearing impairment (DFNA11)","Family-based genetic study","1 family (23 members)","Not specified","Identify and functionally study a new missense mutation in MYO7A in a family with DFNA11.","MYO7A","MYO7A c.2003G>A (p.R668H)","AD","Genome-wide linkage analysis, Sanger sequencing","Progressive, ascending audiogram affecting low/middle frequencies, later all frequencies","Clinical ENT/otoscopic exam and pure-tone audiometry were performed.\nNo dedicated vestibular testing (no calorics, vHIT, cVEMP, etc.).\nNo inner ear malformations or vestibular deficits described.","NA"]
["10.1016/j.gene.2012.09.023","Lezirovitz et al., 2012","Brazil","Autosomal dominant nonsyndromic sensorineural hearing loss","Family-based genetic study","1 family (9 affected)","Not specified","Identify and characterise an aberrant transcript produced by a splice donor site deletion in the TECTA gene.","TECTA","TECTA c.5383+5delGTGA","AD","Linkage analysis, Sanger sequencing, cDNA analysis","Stable, early onset, affecting mid-high frequencies","Clinical ENT exam + audiometry only.\nNo dedicated vestibular testing (no calorics, vHIT, cVEMP, rotary chair, etc.) reported.\nNo vestibular symptoms documented.","NA"]
["10.1007/s11033-012-1929-9","Hashemi et al., 2012","South Iran","Autosomal recessive nonsyndromic sensorineural hearing loss (ARNSHL)","Cross-sectional","50 patients","15 Males, 35 Females/8.5 years","Evaluate the prevalence of GJB2 mutations among affected individuals from south of Iran.","GJB2","GJB2 (35delG, V153I, V27I, M34V, A149T, V198M, L28I, N169T)","AR","Genomic DNA extraction, PCR amplification and Sanger sequencing ","Bilateral Severe to profound sensorineural hearing loss","No formal vestibular testing described.\nClinical ENT exam + audiometry only.\nVestibular symptoms not reported.","not assessed "]
["10.1007/s11033-012-2003-3","Charif et al., 2012","Morocco","Autosomal recessive non-syndromic hearing impairment (ARNSHI)","Case-control","105 families, 120 controls","Not specified","Evaluate the carrier frequency of the LRTOMT c.242G>A mutation and its contribution to deafness.","LRTOMT","LRTOMT c.242G>A (p.R81Q)","AR","Genomic DNA extraction, PCR amplification, Sanger Sequencing and PCR-RFLP","Congenital, prelingual, bilateral; moderate to profound, All nine homozygous families presented nonsyndromic SNHL.","The study did not perform dedicated vestibular testing (no calorics, vHIT, cVEMP, etc.).\nVestibular function inferred from literature and mouse models but not assessed clinically in this cohort.","NA"]
["10.1002/ajmg.a.35572","Babanejad et al., 2012","Iran","SNHL","Homzygosity mapping ","144 families","NA","To identify linked loci and causal variants","MYO15A, SLC26A4, TMC1, TECTA, ILDR1, MARVELD2, PJVK, LRTOMT, OTOF, MYO7A","Total Identified Variants: 33 in 10 genes (MYO15A, MYO7A, SLC26A4, TMC1, OTOF, TECTA, ILDR1, MARVELD2, PJVK, LRTOMT).\nNovel Variants: 9 were previously unreported – notably MYO7A p.Arg373Cys; SLC26A4 p.Gly116Val; LRTOMT p.Met34Ile, p.Glu80Asp, p.Arg81Trp; ILDR1 IVS3+1G>A; TECTA p.Cys1301X; MARVELD2 p.Lys517ArgfsX16; PJVK p.Arg92X.","AR","STR linkage; exon sequencing; segregation testing","Prelingual, nonprogressive, severe to profound","Tandem-gait, Romberg; ABR/TEOAE in subsets","NA"]
["10.1017/S0022215112001119","Battelino, S. et al. (2012)","Slovenia","Progressive non-syndromic sensorineural hearing loss (SNHL)","Cross-sectional genetic association study (progressive HL cohort vs known non-progressive HL data)","72 patients with progressive SNHL from 69 non-consanguineous families","1–65 years (mean 28 years); both sexes included","Investigate molecular basis of progressive SNHL and compare genotypes to non-progressive SNHL","GJB2 (Connexin 26), GJB6 (Connexin 30)","c.35delG (most frequent), c.313_326del14bp, p.Arg127His, p.Val153Ile, novel GJB6 p.Met203Val; plus heterozygous or compound heterozygous variants","AR","PCR amplification of full coding regions of GJB2 and GJB6 with BigDye Terminator sequencing (ABI Prism 310); screening for the 309 kb GJB6-D12S1830 deletion (duplex PCR); Custom TaqMan SNP genotyping for mtDNA A1555G mutation; 100 healthy controls for novel variant validation","Pure-tone audiometry (age-appropriate), tympanometry, ABR/TEOAE for infants, plus longitudinal threshold shifts defined progression; severity classified by PTA in standard WHO categories","No dedicated vestibular function testing performed. Only high-resolution CT or MRI of temporal bone to exclude malformations; clinical otorhinolaryngological exam used to rule out syndromic features.","NA"]
["10.3109/00016489.2012.669498","Löppönen T et al. / 2012","Finland","Nonsyndromic sensorineural hearing impairment (SNHI)","Systematic review of families","11 patients from 6 families","6-23 years of age","To assess whether the p.M34T mutation in the GJB2 gene may associate with nonsyndromic SNHI.","GJB2","p.M34T","AR","PCR amplification of genomic DNA from blood lymphocytes → direct sequencing of coding region using specific primers; detection of heterozygous carriers with conformation-sensitive gel electrophoresis (CSGE) plus sequencing confirmation","Mild to moderate nonsyndromic SNHI; bilateral in almost all; characteristic notch at 2–4 kHz in children/adolescents; BEHL(0.5–4 kHz) ~17.5–40 dB HL depending on case; in older age sometimes sloping high-frequency SNHI resembling presbyacusis; follow-up of some cases showed stability or mild progression in high frequencies over time","No dedicated vestibular function testing reported; otomicroscopy and tuning fork tests to exclude middle ear pathology; primarily audiological assessment (pure-tone audiometry)","NA"]
["10.1016/j.gene.2012.03.060","Minami SB et al. / 2012","Japan","Comorbid hereditary hearing loss of DFNB1 and DFNA6/14","Family study","7 individuals from a four-generation family","Mixed sexes; ages reported include proband 1 year, child 4 years, adult 34 years, adult 61 years.","To report on a family exhibiting comorbid mutation of GJB2 and WFS1.","GJB2, WFS1","WFS1 exon 8 c.2576G>C (R859P, heterozygous)\n- GJB2 exon 2 c.109G>A (V37I, heterozygous or homozygous)\n- GJB2 exon 2 c.427C>T (R143W, heterozygous)","Mixed: WFS1 mutations consistent with autosomal dominant low-frequency SNHL (DFNA6/14); GJB2 mutations classically autosomal recessive (DFNB1). Comorbid carriers showed blended phenotypes.","PCR amplification of entire GJB2 coding region and exons 2–7 of WFS1, plus overlapping PCR products for exon 8 of WFS1; Sanger sequencing using ABI 377XL sequencer; mutations verified in family members.","Low-frequency, moderate flat, or gradual high tone loss depending on genotype","No formal vestibular testing (focus on auditory); history taken; not designed to assess vestibular end-organ function.","NA"]
["10.3109/14992027.2012.660575","Homøe P et al. / 2012","Greenland","Sensorineural and mixed hearing impairment (HI) among East Greenlanders; focus on GJB2 (Connexin-26) mutations","Cross-sectional population-based survey","45 patients with sensorineural or mixed HI (24 males, 21 females; median age 35 years, range 5–76). Controls: 108 East Greenlanders and 109 West Greenlanders. Also reviewed records from nine children at Greenland’s deaf school.","Patients median 35 years (5–76); controls median ~22–24 years; both sexes represented.","To determine the frequency of GJB2 mutations in East Greenlanders with HI and compare with population-based East and West Greenlandic controls.","GJB2","c.35delG mutation: 1 homozygous patient (bilateral congenital profound HI), 1 heterozygous patient (mixed HI), controls 0–5 carriers depending on group.\n- p.V27I variant (polymorphism): 3 heterozygotes among patients.\n- p.V153I variant (polymorphism): 1 heterozygote among patients.\n- p.M34T variant: 1 control heterozygote (unknown hearing status).\n- p.R127H variant: 1 West Greenland control heterozygote (variably reported polymorphism/disease).","AR","PCR amplification of GJB2 exon 2 (928 bp) using CX26F/CX26R primers; BigDye Terminator sequencing on ABI 3130XL; ExoSAP purification. Ethics approvals obtained and informed consent given.","Mixed and sensorineural HI; 56% moderate, 18% severe, 8% profound, 18% mild.\n- One homozygous c.35delG patient: bilateral congenital profound HI.\n- One heterozygous c.35delG: mixed HI likely postinfectious.\n- Chronic otitis media, noise trauma, meningitis and other non-genetic factors frequent.\n- Controls not audiometrically assessed.","None formally performed; only audiometry (pure-tone air/bone conduction). No vestibular end-organ tests.","NA"]
["10.1007/s00405-011-1817-2","Popova DP et al. / 2012","Bulgaria","Severe to profound congenital nonsyndromic sensorineural hearing loss","Prospective study","51 patients (diagnosed at 6–18 months; mean diagnosis age 11.9 ± 3.2 months); 21 males, 30 females; predominantly Bulgarian ethnicity, with small Turkish, Roma and Albanian subgroups","Mean diagnosis age 11.9 months (range 6–18 months); sexes: 21 males / 30 females","To determine the prevalence of GJB2 (Connexin 26) mutations in Bulgarian children with severe to profound congenital nonsyndromic sensorineural hearing loss, including ethnic distribution and novel variants","GJB2","c.35delG/c.35delG: 20 patients (39%) (17 Bulgarian, 3 Turkish) — profound HI (18), severe HI (2)\n- c.35delG/WT: 4 patients (8%), all Bulgarian — profound HI\n- c.35delG + 312del114 (heterozygous): 1 Bulgarian — profound HI\n- W24X (Trp24X) heterozygous: 1 Albanian — profound HI\n- p.Leu90Pro(L90P)/p.Ile121Asn (novel) compound heterozygous: 1 Bulgarian — profound HI\n- Arg127His (R127H) heterozygous: 1 Roma — profound HI\n- WT/WT: 23 patients (45%) — mostly profound HI","AR","Genomic DNA extracted from blood using CHENAGEN magnetic separation; bidirectional sequencing of exons 1 & 2 with BigDye v3.1 on ABI Prism 310; variants annotated.","90% (46/51) profound hearing loss (>90 dBnHL); 10% (5/51) severe (71–90 dBnHL); no moderate cases.\n- Only five had residual hearing.\n- Two c.35delG homozygotes classified as severe rather than profound.\n- Audiology included BERA, tympanometry, TEOAE, tonal audiometry; CT of cochlea performed.","not reported","NA"]
["10.1016/j.ijporl.2011.12.020","Minárik G et al. / 2012","Slovakia","Nonsyndromic hearing loss (NSHL)","cross-sectional population-based mutation screening","273 patients","Not specified","To determine the proportion and spectrum of DFNB1 mutations (GJB2 & GJB6) in sporadic Slovak NSHL patients and optimize a population-specific screening protocol","GJB2, GJB6","Causal mutations (11 total): IVS1+1G>A, c.35delG, W24X, V37I, E47X, 167delT, V84M, L90P, 310del14, 333–334delAA, R184Q. Polymorphisms (7 total): V27I, M34T, F83L, 354C>T, R127H, V153I, 684C>A. Key frequencies:\n• c.35delG homozygous: 43/273 (15.75%)\n• Various compound heterozygotes (e.g., 35delG/310del14, 35delG/L90P, etc.) – see Table 1 of paper.\n• W24X/W24X in 5 cases; W24X common in Roma/Gypsy.\n• No GJB6 del(D13S1830) detected.","AR","PCR and Sanger sequencing of GJB2 coding & noncoding regions; PCR for IVS1+1G>A; PCR for GJB6 deletion. Amplicons validated with internal positive control assays.","Severe to profound NSHL (prelingual). No exact dB distribution provided but selection targeted congenital/sporadic NSHL.","not reported","NA"]
["10.1007/s00439-011-1083-9","Taokesen M et al. / 2011","Southeastern Turkey","Alström syndrome","Case study of a kindred","Two affected cousins; extended family genotyped for segregation and 29 villagers + 50 unrelated Turkish controls screened for allele frequency","Proband: 13-year-old boy (severe multisystem ALMS, bilateral SNHL). Cousin: 6-year-old girl (visual loss + obesity, but normal hearing at diagnosis)","To identify and characterize a novel pathogenic variant in ALMS1 and assess its frequency in the isolated population","ALMS1","Novel Alu retrotransposon insertion (Alu Ya5, 333 bp) into exon 16 of ALMS1 leading to premature stop codon and loss of function. Target-site duplication matching consensus Alu insertion motif (TT^AAAA).","AR","PCR amplification of ALMS1 exon 16, Sanger sequencing, haplotype analysis with 2p13 microsatellite markers, PCR genotyping for Alu allele (size shift 313 bp WT vs. 646 bp mutant). Comparison to Repbase and analysis of truncation features.","Patient 1 (male, 13 y): bilateral progressive sensorineural hearing loss, total blindness, T2DM, obesity, LV hypertrophy, renal failure, died at 14 y from CHF and multi-organ failure.\nPatient 2 (female, 6 y): visual loss and obesity, normal hearing at time of assessment, normal renal/cardiac function.","not reported","NA"]
["10.1016/j.ijporl.2011.11.019","Davarnia B et al. / 2012","Iran","Nonsyndromic autosomal recessive hearing loss","Cross-sectional screening","50 families","Not stated","To determine the prevalence and spectrum of GJB2 mutations in Iranian Azeri families and test for GJB6 deletions","GJB2 (connexin 26) – DFNB1 locus; GJB6 screened for del(D13S1830) and del(D13S1854)","Homozygous c.35delG in 9/50 families (69.2% of mutations), Homozygous delE120 in 1/50, Homozygous 299–300delAT in 1/50, Novel homozygous c.463–464delTA in 2/50 (frameshift at codon 155 → premature stop at codon 208), Variants A171T (het) and V27I+E114G (het) detected; no exon 1 mutations., No del(GJB6-D13S1830) or del(GJB6-D13S1854) detected.","AR","Allele-specific PCR for c.35delG followed by direct sequencing of GJB2 (exons 1–2 + flanking regions) and PCR screening for GJB6 large deletions (del(D13S1830), del(D13S1854)","Severe to profound","not reported","NA"]
["10.1016/j.ijporl.2011.11.009","Qu C et al. / 2012","China","Sporadic nonsyndromic hearing loss","Cross-sectional molecular screening","179 children","6 months–13 years old; mean 6 ± 1.5 years","Identify molecular causes of sporadic pediatric NSHL using a multiplex microarray panel","GJB2, SLC26A4, GJB3, 12S rRNA (MT-RNR1)","GJB2: 235delC (most common, 79% of mutant alleles), 299_300delAT, 176_191del16, 35delG\n SLC26A4: IVS7-2A>G, 2168A>G\n 12S rRNA: 1555A>G\n GJB3: 538C>T","AR, and mtDNA","CapitalBio Deafness Gene Mutation Detection Array Kit (China SFDA-cleared): multiplex allele-specific PCR and arrayed primer extension (APEX) on a microarray chip to detect 9 hotspot mutations across 4 genes. Confirmation of heterozygous/homozygous status by PCR; control cohort screened similarly.","All children had moderate to profound bilateral sensorineural hearing loss documented by pure-tone audiometry and/or ABR; unilateral or syndromic cases excluded.","not reported","NA"]
["10.1371/journal.pone.0051566","Khateb S et al. / 2012","Israel","Autosomal recessive retinitis pigmentosa (arRP) with late-onset hearing loss","Homozygosity mapping and whole exome sequencing (WES)","16 patients from multiple families","Age range 13-72y","Identify the genetic cause of arRP in Yemenite Jewish families with possible founder effect and characterise associated hearing phenotype","USH1C","c.1220delG (novel frameshift)","AR","Whole-genome SNP homozygosity mapping → whole exome sequencing (Roche NimbleGen V2 capture + Illumina HiSeq2000; ANNOVAR pipeline) → variant filtering (MAF <0.5%, AR inheritance) → Sanger sequencing to confirm and screen additional cases. RT-PCR and expression analysis of USH1C transcripts in retina and other tissues.","Late onset, mild to severe high tone sensorineural","Questionnaire for vestibular symptoms; no formal vestibular lab testing reported.","none reported"]
["10.1371/journal.pone.0049984","Yuan Y et al. / 2012","China","Non-syndromic hearing loss with enlarged vestibular aqueduct (EVA)","Large-scale molecular epidemiological survey and functional assessment","2352 patients","Both, average age 14.17y","Determine SLC26A4 mutation spectrum and prevalence of EVA; functionally characterize novel SLC26A4 variants","SLC26A4","86 distinct variants identified (47 novel). Most common: IVS7-2A>G and p.H723R. Ten variants selected for functional assays: p.D87Y, p.S93R, p.G222V, p.S314L, p.A360V, p.R409C, p.L506R, p.C662Y, p.A664V, p.R776G.","AR","Stepwise sequencing of SLC26A4 exons: (i) first exons 8, 10, and 19 in all patients (hot-spot regions), (ii) full exon-by-exon sequencing for those with one variant, covering exons 2–20 + flanking intronic regions; Big Dye sequencing on ABI 3100. Controls screened by DHPLC then sequencing. Functional assays: cDNA cloning of pendrin, site-directed mutagenesis to introduce 10 variants, transient transfection of HEK cells, confocal microscopy for membrane localization, [14C] formate uptake radioisotope transport assays.","Moderate to profound bilateral sensorineural","EVA diagnosed radiologically by temporal bone CT scan (and MRI in some cases); inner ear malformation classified as >1.5 mm vestibular aqueduct diameter. No dedicated vestibular functional tests beyond imaging.","EVA in at least 11% of the Chinese NSHL cohort (13% in Han); distinct geographic and ethnic distribution. No clinical goiter (i.e. non-syndromic EVA)."]
["10.1371/journal.pone.0036354","Danilenko N et al. / 2012","Belarus","Non-syndromic sensorineural hearing loss (SNHL)","Population-based genetic study","391 patients, 757 controls","Patients aged 1-25y","To study GJB2 and mitochondrial mutations in Belarusians and SNHL patients.","GJB2, GJB6, mt-RNR1, mt-TS1","35delG, 312del14, A1555G, G7444A","AR","Sequencing, SSCP, multiplex PCR for deletion","Moderate to profound, mainly severe and profound with 35delG/35delG genotype","None beyond standard audiological testing; study focused on cochlear/NSHL genetics.","NA"]
["10.1371/journal.pone.0030720","Yuan Y et al. / 2012","China (Tibet)","Nonsyndromic hearing impairment","Molecular etiology investigation and radiological comparison","114 patients, 106 controls","M/F, average age 12.10y","To investigate the molecular etiology of nonsyndromic deafness in the Tibetan Chinese population.","GJB2, SLC26A4, GJB6, POU3F4, mtDNA 12S rRNA","A1555G","mtDNA","Sequencing, temporal CT scan","Moderate to profound bilateral sensorineural","No dedicated vestibular lab testing; used temporal bone CT to identify inner ear malformations (osseous labyrinth).","Inner ear malformations in 20.2% of Tibetan patients (23/114), but no EVA detected (vs 18.3% EVA in Han patients). Malformations included hypoplastic cochlea, narrow/enlarged IAC, malformation of vestibular/semicircular canals, incomplete partition type I, and common cavity; ossification of inner ear in one case."]
["10.1136/jmedgenet-2011-100468","Le Quesne Stabej P et al. / 2012","United Kingdom","Usher syndrome (USH)","Comprehensive clinical and genetic analysis","172 patients","Not stated","To examine the molecular epidemiology of USH in the UK and evaluate the contribution of digenic inheritance.","MYO7A, USH1C, CDH23, PCDH15, USH1G, USH2A, GPR98, WHRN, CLRN1","Multiple, including USH1C:c.496+1G>A and USH2A:p.Glu767SerfsX21","AR","Bidirectional DNA sequencing, MLPA","Sensorineural hearing loss, RP","Comprehensive vestibular battery: infrared video nystagmography, rotary chair (VOR gain and time constant), binaural bithermal caloric testing with water per BSA protocol, canal paresis and directional preponderance calculated by Jongkees formulae, sinusoidal/step rotation testing.","Vestibular dysfunction depending on USH type"]
["10.1186/1750-1172-6-88","Swinnen FKR et al. / 2011","Belgium, The Netherlands, Italy","Osteogenesis Imperfecta (OI)","Cohort study","184 patients from 89 families","M/F, aged 3-89y","To evaluate inter- and intrafamilial variability in hearing loss and correlate with genotype.","COL1A1, COL1A2","Various nonsense, frameshift, splice site, and glycine substitutions","AD","PCR, sequencing, DHPLC","Conductive, mixed, or sensorineural; adult-onset","None systematically (focus on audiometry). Otological history taken for otitis media, skull fracture, noise exposure.","NA"]
["10.3109/14992027.2011.603757","Chinetti V et al. / 2011","Italy","Non-syndromic hearing-impaired infants","Universal neonatal hearing screening programme","129 infants","Not stated","To determine the incidence of GJB2, GJB3, and GJB6 mutations in infants in Southern Italy.","GJB2, GJB3, GJB6","c.35delG, p.M1W/p.W24X, p.L90P","AR","PCR and direct sequencing","Symmetrical severe loss for c.35delG homozygotes, milder in compound heterozygotes","not reported","NA"]
["10.1186/1479-5876-9-167","Huang S et al. / 2011","China","Non-syndromic hearing loss with inner ear malformation","Comparative study","144 patients","M/F, aged 10 months to 25 years","To assess whether SLC26A4 mutations cause isolated Mondini deformity without EVA.","SLC26A4","c.919-2A>G, p.H723R, and 13 novel variants","AR","DNA sequence analysis, temporal bone CT scan","Moderate to profound sensorineural","Not formally tested; vestibular status inferred from imaging (EVA, MD, other IEM).","NA"]
["10.1186/1479-5876-9-154","Chen Y et al. / 2011","China (Xinjiang)","Non-syndromic deafness (NSD)","Comparative study","199 Uyghur, 151 Han Chinese patients","M/F, aged 1-35y (Uyghur), 1-26y (Han)","To characterize deafness-associated gene mutations in Uyghur NSD patients in comparison with Han Chinese patients.","GJB2, GJB3, SLC26A4, mtDNA 12S rRNA","9 hotspot mutations, including 235delC, 35delG, 187delG (novel) in GJB2","AR, and mtDNA","Microarray and DNA sequencing","Moderate or severe sensorineural","NA","NA"]
["10.1016/S1674-8301(11)60042-0","Lu et al. / 2011","China (Hubei)","Hearing loss","Population screening","813 students","M/F","To characterize the forms and frequencies of GJB2 and mtDNA 1555A>G mutations in students with hearing loss.","GJB2, MTRNR1 (mtDNA 12S rRNA)","10 different GJB2 mutations (incl. c.235delC, c.299_300delAT), mtDNA 1555A>G","AR, and mtDNA","PCR, sequencing, enzyme digestion","Profound prelingual with two GJB2 mutations; various with mtDNA","NA","NA"]
["10.1016/j.ijporl.2011.06.011","Chen  et al. / 2011","Russia (Eastern Siberia)","Autosomal recessive deafness 1A (DFNB1A)","Molecular, audiological, and population study","86 patients","M/F, aged 0-44y","To study DFNB1A associated with IVS1+1G4A mutation of GJB2 in the Yakut population.","GJB2","IVS1+1G4A","AR","Sequencing, PCR-RFLP, haplotype analysis","Severe to profound bilateral sensorineural","NA","NA"]
["10.1038/jhg.2011.72","Yoong SY et al. / 2011","United Kingdom","Non-syndromic sensorineural hearing loss (SNHL)","Retrospective cohort study","177 children (147 British Pakistani, 30 British White)","M/F, aged 0-18y","To determine clinical sensitivity of DFNB1 genetic testing for SNHL in British Pakistani children.","GJB2, GJB6","p.Trp24X, c.35delG, p.Glu47X","AR","Sequencing, targeted analysis for specific mutations","Moderate to profound bilateral SNHL","NA","NA"]
["10.1136/adc.2010.209262","Zhao F-F et al. / 2011","China","Nonsyndromic sensorineural hearing impairment (NSSHI)","Cross-sectional study","295 patients","M/F, median age 14y","To clarify correlations between different GJB2 biallelic genotypes and NSSHI phenotype in Chinese population.","GJB2","c.235delC, p.V37I, [p.V27I;p.Glu114Gly], and others","AR","DNA sequencing of exons","Mild to profound, more severe with two truncating mutations","NA","NA"]
["10.1089/gtmb.2010.0192","Hildebrand MS et al. / 2011","Spain, USA, Belgium, UK","Autosomal dominant nonsyndromic hearing loss (ADNSHL)","Unbiased and biased genetic screening","372 Spanish probands, 73 American probands, 3 other families","Not stated","To investigate the prevalence of DFNA8/12 and TECTA mutations.","TECTA","20 novel mutations, p.C1036Y, p.C1837G, p.T1866M, p.R1890C","AD","Sequencing, DHPLC, Linkage Analysis","Mid-frequency or high-frequency SNHL depending on mutation location","NA","NA"]
["10.1002/humu.21512","Rezaei H, Vallian S / 2011","Iran","Non-syndromic sensorineural hearing loss (NSHL)","Haplotype frequency analysis","100 healthy individuals","Not stated","To investigate genotyping and haplotype frequency of three markers at the GJB2 region.","GJB2","BanI, D13S141, D13S175 (polymorphic markers)","AR","PCR-RFLP, PAGE, sequencing, haplotype frequency estimation","Not applicable (control population)","NA","NA"]
["10.1007/s10571-011-9683-4","Pauw RJ et al. / 2011","Australia","Autosomal dominant sensorineural hearing impairment (DFNA9)","Retrospective analysis","8 mutation carriers from one family","Not stated","To study clinical characteristics of an Australian family with DFNA9 caused by an I109N COCH mutation.","COCH","I109N","AD","Retrospective analysis of existing data","Progressive high-frequency SNHL, starts before age 40","NA","Vestibular symptoms reported in 5 patients"]
["10.1177/000348941112000612","Chen Y et al. / 2011","China","Non-syndromic deafness (NSD)","Comparative study","199 Uyghur, 151 Han Chinese patients","M/F, aged 1-35y (Uyghur), 1-26y (Han)","To characterize nine loci of four deafness-associated genes of Uyghur NSD patients in comparison with Han Chinese patients.","GJB2, GJB3, SLC26A4, mtDNA 12S rRNA","Multiple, incl. 235delC, 35delG, and novel 187delG in GJB2","AR, and mtDNA","Microarray and DNA sequencing","Moderate or severe sensorineural","temporal bone CT/MRI for inner ear malformations; no functional vestibular testing.","NA"]
["10.1002/lary.21751","Kabahuma RI et al. / 2011","South Africa","Nonsyndromic genetic hearing loss","Population-based screening","182 students, 63 controls","M/F, aged 5-21y","To determine the prevalence of mutations in GJB2, GJB6, and four common mitochondrial mutations.","GJB2, GJB6, mtDNA","Multiple common mutations","AR, and mtDNA","SSCP, sequencing, multiplex PCR, PCR-RFLP","Severe to profound, majority flat or sloping audiograms","temporal bone CT/MRI for inner ear malformations; no functional vestibular testing.","NA"]
["10.1016/j.ijporl.2011.01.029","Zhang J et al. / 2011","China","Less severe idiopathic hearing loss","Genotype-phenotype correlation study","236 patients","M/F, mean age 30.74y","To explore correlations between GJB2 genotype and audiogram features in patients with less severe HL.","GJB2","p.V37I, c.235delC, [p.V27I; p.E114G], and others","Biallelic/single pathogenic mutations or polymorphisms","DNA sequencing of exon 2","Mild to severe SNHL; asymmetric HL with biallelic mutations","NA","NA"]
["10.1089/gtmb.2010.0182","al-Achkar W et al. / 2011","Syria","Non-syndromic recessive congenital hearing impairment","Mutation frequency study","50 families, 180 controls","M/F, aged 2-18y","To determine the prevalence of six GJB2 mutations in Syrian patients.","GJB2","35delG, 167delT, M34T","AR","PCR-RFLP, direct sequencing","Profound bilateral hearing loss","NA","NA"]
["10.3892/mmr.2011.428","Sun Y et al. / 2011","China","Non-syndromic low-frequency sensorineural hearing loss (LFSNHL)","Family study and mutational screening","1 family (23 members), 37 sporadic patients","Not stated","To identify mutations in DIAPH1 and WFS1 associated with LFSNHL.","WFS1","H696Y, R703H (novel missense)","AD","Linkage analysis, genome-wide scan, sequencing","Postlingual, progressive low-frequency, ascending audiogram","NA","Vertigo reported in 4 affected members"]
["10.1016/j.jcg.2011.01.001","Sun et al. / 2011","China","Sporadic nonsyndromic sensorineural hearing loss (NSHL)","Molecular epidemiological analysis","473 patients","M/F, median age 5.0y","To examine mutations of GJB2, SLC26A4, and mtDNA A1555G in sporadic NSHL outpatients.","GJB2, SLC26A4, mtDNA 12S rRNA","c.235delC, c.299_300delAT (GJB2); A1555G (mtDNA)","AR, and mtDNA","RFLP analysis, sequencing","Severe or profound hearing loss","Electrocochleography (ECochG) performed to assess SP/AP ratios; no vestibular dysfunction reported.","NA"]
["10.3109/00016489.2010.483479","Jones SM et al. / 2011","USA","DFNA9 (human), Late-onset hearing loss and vestibular dysfunction (mouse)","Comparative study of mouse models and human data","Mice (Coch+/+, CochG88E/G88E, Coch-/-)","Mice (M/F)","To compare hearing and vestibular deficits in two mouse models to human DFNA9 disorder.","COCH (human), Coch (mouse)","Multiple missense and in-frame deletions (human); G88E knock-in and knock-out (mouse)","AD","ABR, VsEP, histological evaluation","Late-onset, progressive, sensorineural","Inner ear malformations (including EVA) were excluded by temporal bone imaging; no functional vestibular tests.","Vestibular dysfunction"]
["10.1007/s11033-010-0231-y","Elia A et al. / 2011","Cyprus, Greece","Distal renal tubular acidosis (dRTA)","Clinical and genetic investigation","9 families from Cyprus, 1 from Greece","M/F","To investigate dRTA cases in Cyprus and Greece, and perform prenatal diagnosis.","ATP6V1B1","229+1G>T, R157C, L81P, 912delT (novel)","AR","DNA resequencing, PCR-RFLP","Progressive sensorineural hearing loss (SNHL)","NA","NA"]
["10.1001/archoto.2010.234","Sun Y et al. / 2011","China","Non-syndromic sensorineural deafness (DFNA11)","Clinical, genetic, and molecular characterization","2 large families","Not stated","To characterize two Chinese families with high- or low-frequency DFNA11.","MYO7A","p.D218N, p.G671S (novel missense)","AD","Genome-wide linkage analysis, DNA sequencing, ECochG","Progressive high- or low-frequency SNHL","NA","NA"]
["10.1038/jhg.2010.147","Chan DK et al. / 2011","USA","Idiopathic congenital sensorineural hearing loss","Retrospective case series","271 patients","M/F, mean age 5.8y","To determine if diagnostic yield on GJB2 sequencing and CT is related to patient ethnicity.","GJB2","c.35delG, p.V37I","AR","Sequencing, CT imaging","Mild to profound, varies with ethnicity and genotype","Electrocochleography (ECochG) was performed; vestibular symptoms were absent in affected subjects.","NA"]
["10.1097/MAO.0b013e3181fc786f","Radulescu L et al. / 2011","Romania","Non-syndromic severe to profound congenital hearing loss","Retrospective study","45 patients","M/F","To characterise and establish the prevalence of GJB2 and GJB6 gene mutations in cochlear implanted recipients from Eastern Romania.","GJB2, GJB6","c.35delG, p.W24*, c.313_326del14, p.delE120, p.R184P, c.299_300delAT","AR","Sequencing, deletion analysis","Congenital or progressive early-onset, severe to profound SNHL","NA","NA"]
["10.1159/000320192","Tsukada K et al. / 2010","Japan","Hereditary hearing loss","Large cohort study","1511 families","Not stated","To estimate GJB2 mutation frequency, spectrum, and associated clinical features in Japanese hearing loss families.","GJB2","c.235delC, p.V37I, and 24 other variants","AR","Sequencing, computational analysis","Severe with c.235delC, milder with p.V37I","NA","Near absence of vestibular dysfunction"]
["10.1111/j.1399-0004.2010.01407.x","Teek R et al. / 2010","Estonia","Early onset hearing loss","Prevalence study","233 patients, 998 neonates","Children 0-18y","To determine the prevalence of c.35delG and p.M34T mutations in the GJB2 gene.","GJB2","c.35delG, p.M34T, and 6 others","AR","Arrayed primer extension (APEX) assay, PCR-RFLP","Profound to moderate with c.35delG, mild with p.M34T","NA","NA"]
["10.1016/j.ijporl.2010.05.026","Cengiz FB et al. / 2010","Turkey","Autosomal recessive nonsyndromic sensorineural hearing loss","Autozygosity mapping and mutation screening","104 families","Not stated","To find MYO15A mutations associated with nonsyndromic autosomal recessive deafness in Turkey.","MYO15A","p.Y289X, p.V1400M, p.S1481P, p.R1937TfsX10, p.S3335AfsX121 (all novel)","AR","Autozygosity mapping, PCR-SSCP, sequencing","Severe to profound sensorineural hearing loss","NA","NA"]
["10.1089/gtmb.2010.0039","Hochman JB et al. / 2010","Canada","Early idiopathic or hereditary progressive sensorineural deafness","Prevalence study","57 adult patients","Not stated","To assess the prevalence of GJB2, GJB6, and SLC26A4 mutations in adult cochlear implant patients.","GJB2, GJB6, SLC26A4","c.35delG, c.167delT, c.235delC/p.E47X (GJB2); multiple in SLC26A4","AR","Sequencing, MLPA","Severe sensorineural, some progressive","Patients examined for vestibular findings during clinical ENT and genetics assessment.","NA"]
["10.1097/MAO.0b013e3181e3d324","Cordeiro-Silva MF et al. / 2010","Brazil","Non-syndromic deafness","Prevalence study","77 individuals","M/F, aged 1-52y","To determine the prevalence of 35delG/GJB2 and del(GJB6-D13S1830) mutations.","GJB2, GJB6","35delG, del(GJB6-D13S1830), del(GJB6-D13S1854)","AR, and Digenic","PCR-RFLP, multiplex PCR","Moderate to profound sensorineural","Electronystagmography and temporal bone CT performed during cochlear implant candidate assessment.","NA"]
["10.1590/S1808-86942010000400004","Pourová R et al. / 2010","Czech Republic","Early hearing loss","Mutation screening and clinical/radiological evaluation","303 patients","Not stated","To determine the spectrum and frequency of SLC26A4 mutations in Czech patients.","SLC26A4","21 different mutations (4 novel), incl. p.Val138Phe and p.Leu445Trp","AR","Direct sequencing, MLPA","Progressive and/or fluctuant hearing loss with EVA/MD","NA","Vestibular impairment is inconsistent"]
["10.1111/j.1469-1809.2010.00581.x","Chen H et al. / 2010","China","Waardenburg syndrome (WS) type I or type II","Mutation screening","18 patients from 15 families","M/F, aged 1-42y","To report mutations in PAX3, MITF, SNAI2, and SOX10 genes in Chinese WS patients.","PAX3, MITF, SOX10","9 mutations (7 novel) across the three genes","AD","PCR and sequencing","Congenital, bilateral profound sensorineural","Vestibular methodology: High-resolution CT/MRI of temporal bone to detect enlarged vestibular aqueduct (EVA) or Mondini dysplasia.","NA"]
["10.1016/j.bbrc.2010.05.066","Chen H et al. / 2010","China","Waardenburg syndrome (WS) type I or type II","Mutation screening","18 patients from 15 families","M/F, aged 1-42y","To report mutations in PAX3, MITF, SNAI2, and SOX10 genes in Chinese WS patients.","PAX3, MITF, SOX10","9 mutations (7 novel) across the three genes","AD","PCR and sequencing","Congenital, bilateral profound sensorineural","NA","NA"]
["10.1016/j.ijporl.2010.03.004","Shan et al./2010","USA","Non-syndromic sensorineural hearing impairment (NSHI)","Cohort study","209 probands","Not specified","Determine the prevalence of GJB2 mutations in Caribbean Hispanic and African admixture populations.","GJB2, GJB6","35delG, E47X, R32C, L90P, V37I, 167delT, M34T, R143W, V27I, R127H, and others","AR, and AD","Bidirectional sequencing, multiplex PCR, MLPA","Ranged from unilateral mild to bilateral profound; 76% bilateral","NA","NA"]
["10.3390/genes1010023","Sand et al./2010","Germany","Chronic tinnitus","Cross-sectional screening","201 outpatients","M: 152, F: 49/Mean age: 49.9 yrs","Screen for KCNE1 mutations in patients with chronic tinnitus and assess association with tinnitus severity.","KCNE1","S28S, G38S, V47I (novel), D85N, and others","NS","Direct sequencing, PCR","Frequently associated with sensorineural hearing loss","NA","NA"]
["10.3109/14992021003601756","Franzè et al./2010","Italy","Sensorineural hearing loss (SNHL)","Screening study","349 unrelated subjects","Not specified/Age range: 4-50 yrs","Screen for GJB2/GJB6 mutations in SNHL patients from southern Italy and correlate genotype with hearing loss severity.","GJB2, GJB6","c.35delG, V27I, E114G, V37I, M34T, IVS 1+1G>A, del(GJB6-D13S1830), and others","AR, and AD","Direct sequencing, PCR","Ranged from mild to profound, congenital/early childhood or postlingual onset","NA","NA"]
["10.1016/j.ijporl.2009.12.015","Lazăr et al./2010","Romania","Nonsyndromic sensorineural hearing loss (NSHL)","Cross-sectional prevalence study","75 unrelated children","Not specified","Determine the prevalence of c.35delG and p.W24X mutations in NSHL patients in North-West Romania.","GJB2, GJB6","c.35delG, p.W24X","AR","Semi-nested PCR-RFLP, ARMS-PCR","Moderate, severe, or profound congenital sensorineural hearing loss","NA","NA"]
["10.1159/000297216","Bartsch et al./2010","Germany","Nonsyndromic sensorineural hearing loss (SNHL)","Retrospective cohort survey","335 patients (319 families)","Not specified/Age range: 1 mo - 46 yrs","Survey molecular analyses of GJB2 and GJB6 genes and analyse genotype-phenotype correlations.","GJB2, GJB6","c.35delG, p.L90P, p.M34T, p.W24X, and 25 others including 3 novel mutations","AR","GJB2 sequence analysis, PCR","Mild-to-profound SNHL; progressive in 27% of biallelic cases","NA","NA"]
["10.1001/archoto.2009.202","Kenna et al./2010","USA","Sensorineural hearing loss (SNHL) with biallelic GJB2 mutations","Prospective, observational study","126 children","F: 76, M: 50/Median age: 2.5 yrs","Document the audiologic phenotype of children with biallelic GJB2 mutations and correlate it with genotype.","GJB2, GJB6","35delG, 167delT, 235delC, M34T, V37I, and 25 others","Biallelic recessive","Sequencing, PCR","Ranges from mild to profound, usually congenital; progressive in over 50% of cases","NA","NA"]
["10.1002/ajmg.a.33114","Campbell et al./2010","USA/Japan","Menière disease (MD)","Case-control association study","180 Caucasian patients, 180 matched controls","M: 78, F: 102/Average age: 54.3 yrs","Replicate a reported association between SNPs in KCNE1/KCNE3 and MD in a Caucasian population.","KCNE1, KCNE3","rs1805127 (S38G), rs2270676 (F66F), and 12 other SNPs","NS","Sequencing, SNP genotyping","Sensorineural hearing loss (part of MD triad)","NA","Vertigo"]
["10.1159/000255339","Topsakal et al./2010","Belgium/ The Netherlands/ Denmark","Autosomal dominant sensorineural hearing loss (ADSNHL), DFNA22","Family/Phenotype study","Two Belgian families (30 affected members)","Not specified","Describe and compare the phenotype of families with ADSNHL linked to DFNA22 due to MYO6 mutations.","MYO6","Missense, splice site, nonsense mutations and overexpression","AD","Audiological and vestibular testing, CT scans","Late-onset, progressive, mild to moderate SNHL; flat or U-shaped audiograms","NA","NA"]
["10.1159/000254487","Dalamón et al./2010","Argentina","Sensorineural hearing impairment (HI)","Prospective cohort/Mutation analysis","252 unrelated patients","Not specified","Analyse the prevalence and spectrum of mutations in GJB2/GJB6 and describe novel mutations in an Argentinean population.","GJB2, GJB6, OTOF, MTRNR1","c.35delG, p.Val27Ile, p.Met34Thr, and 28 others including 2 novel mutations","AR, and AD","Direct sequencing, PCR, RFLP","Ranged from mild to profound, mostly congenital/prelingual","NA","NA"]
["10.1002/lary.20691","Fujikawa et al./2010","Japan","Autosomal dominant nonsyndromic SNHL","Family study","One 4-generation Japanese family (15 participants)","Not specified","Identify the causative gene in a Japanese family with progressive SNHL and characterise the audiovestibular profile.","WFS1, TECTA, GJB2","K836T (novel missense in WFS1), and various polymorphisms","AD","Direct sequencing, PCR","Mid-frequency SNHL in childhood, progressing at lower frequencies with age","Vestibular function assessed by nystagmus tests and caloric electronystagmography; all results normal.","NA"]
["10.1002/lary.20621","Wu et al./2009","Taiwan","Idiopathic nonsyndromic sensorineural hearing impairment (SNHI)","Diagnostic tool development and validation in a prospective cohort","214 unrelated Taiwanese patients","Not specified","Develop a cost-effective genetic diagnostic tool (SNaPshot multiplex assays) for idiopathic SNHI.","GJB2, SLC26A4, mitochondrial 12S rRNA","20 common sequence variants including c.109G>A, c.235delC, c.919-2A>G, m.1555A>G","AR","SNaPshot multiplex assays, direct sequencing, PCR","Idiopathic bilateral SNHI","NA","NA"]
["10.1089/gtmb.2009.0044","Kunishima et al./2009","Japan","Nonsyndromic deafness (DFNA17)","Mutational screening study","157 unrelated Japanese patients","Not specified","Investigate the prevalence of MYH9 mutations in Japanese patients with nonsyndromic deafness.","MYH9","R705H (specifically exon 16), and exons 1, 26, 30","AD","PCR, mutational analysis","High-frequency sensorineural hearing loss","NA","NA"]
["10.1016/j.ijporl.2009.06.009","Dietz et al./2009","Finland","Congenital or early acquired bilateral sensorineural hearing impairment (SNHI)","Retrospective cohort study","92 children","M: 44, F: 49/Diagnosed before age 7","Determine the prevalence and etiology of congenital/early acquired bilateral SNHI in Eastern Finland.","GJB2","35delG, M34T, R143W, V37I","AR","Retrospective record review","Ranged from mild to profound, congenital or early acquired","NA","NA"]
["10.1152/physiolgenomics.00047.2009","Dai et al./2009","China/USA","Nonsyndromic hearing loss with/without enlarged vestibular aqueduct (EVA)","Mutation screening and functional analysis","55 Chinese, 255 US subjects, plus controls","Not specified","Define the SLC26A4 mutation spectrum in Chinese and US subjects and functionally test novel mutations.","SLC26A4","10 novel variants (4 Chinese, 6 US), c.919-2A>G, p.H723R, and others","AR","DHPLC, direct DNA sequencing, functional analysis","Sensorineural hearing loss, often with temporal bone abnormalities (TBA) like EVA","High-resolution CT imaging of the temporal bone to identify EVA.","NA"]
["10.1016/j.bbrc.2009.05.083","Bhalla et al./2009","India","Non-syndromic hearing impairment (NSHI)","Case-control/Screening study","210 NSHI patients, 101 controls","M: 107, F: 103 (patients)/Not specified","Screen for GJB2, GJB6, and mitochondrial DNA mutations in a North Indian NSHI cohort.","GJB2, GJB6, mtDNA (12S rRNA, tRNALeu, tRNASer)","35delG, W24X, W77X, delE120, R127H, V153I, DGJB6-D13S1830, A1555G, A3243G, A7445G","AR","PCR-RFLP, AS-PCR, DHPLC, direct sequencing","Bilateral, severe to profound sensorineural hearing impairment","NA","NA"]
["10.1111/j.1399-0004.2009.01183.x","Sırmacı et al./2009","Turkey","Autosomal recessive non-syndromic sensorineural hearing loss (ARNSSNHL)","Linkage analysis and mutation screening","258 families","Not specified","Investigate the frequency and origin of TMIE mutations as a cause of ARNSSNHL in Turkey.","TMIE, GJB2","p.R84W, p.W57X (novel)","AR","Genome-wide SNP genotyping, linkage analysis, direct sequencing, SSCP","Congenital/prelingual onset, severe to profound sensorineural hearing loss","NA","NA"]
["10.1177/000348940911800511","de Heer et al./2009","The Netherlands","Autosomal dominant nonsyndromic hearing impairment (DFNA20/26)","Family/Phenotype study","One 5-generation Dutch family (33 participants)","Not specified","Analyze the phenotype in a DFNA20/26 family with a novel ACTG1 mutation and compare with previous reports.","ACTG1","c.151G>A (D51N)","AD","Audiometric and vestibular testing, mutation analysis","High-frequency hearing impairment, progressive, ultimately resulting in residual hearing","Vestibular function tested with velocity-step and caloric tests; no consistent abnormalities found.","NA"]
["10.1038/jhg.2009.21","Anwar et al./2009","Pakistan","DFNB4 deafness and Pendred’s syndrome (PDS)","Mutation and haplotype analysis in a large cohort","563 consanguineous Pakistani families","Not specified","Define the identities and frequencies of SLC26A4 mutations in a large cohort of Pakistani families with recessive deafness.","SLC26A4","p.V239D, p.Q446R, p.S90L, and 13 others including 8 novel variants","AR","Sequence analysis, STR genotyping, ARMS assay","Severe-to-profound, prelingual/congenital recessive deafness","Vestibular function assessed by tandem gait and Romberg testing in affected family members.","NA"]
["10.1038/ejhg.2008.231","Doucette et al./2009","Canada/USA","Autosomal recessive non-syndromic sensorineural hearing loss (DFNB23)","Linkage analysis and gene identification in a single large family","One consanguineous family (134 relatives)","Not specified","Map the deafness trait and identify the causative mutation in a large consanguineous family from Newfoundland.","PCDH15, CDH23, GJB2, GJB6, TMPRSS3, WFS1","c.1583 T>A (V528D) in PCDH15","AR","Genome-wide scan, fine mapping, direct sequencing, haplotype analysis","Prelingual, severe to profound sensorineural hearing loss","Vestibular function assessed by caloric, oculomotor, positional, and Dix-Hallpike tests; all normal.","NA"]
["10.1177/000348940911800413","de Heer et al./2009","The Netherlands","Autosomal dominant nonsyndromic hearing impairment (DFNA15)","Family/Phenotype study","One 4-generation Dutch family (40 participants)","Not specified","Characterise cochleovestibular features in a DFNA15 family with a novel POU4F3 mutation (L223P).","POU4F3","L223P","AD","Audiometric and vestibular testing, mutation analysis","Early-adult to midlife onset, high-frequency hearing impairment, progressive","Vestibular function assessed by vestibulo-ocular reflex velocity-step and caloric tests in mutation carriers.","Hypofunction of the vestibular labyrinth in 2 carriers (not statistically significant)"]
["10.1111/j.1749-4486.2009.01888.x","Bajaj et al./2009","UK","Sensorineural deafness in British Bangladeshi children","Cross-sectional survey","134 patients (115 families)","M: 71, F: 63/Age range: 9 mo - 18 yrs","Study the causes and prevalence of sensorineural deafness in Bangladeshi children in East London.","GJB2","W24X, IVS1+1, M1V, W77X, Q124X","AR","Genetic analysis","Bilateral sensorineural hearing loss >40 dB HL","NA","NA"]
["10.1016/j.mrfmmm.2008.11.019","Wang et al./2009","China","Dentinogenesis imperfecta type II (DGI-II)","Family/Genetic linkage and mutation analysis study","One 6-generation family (24 affected individuals)","Not specified","Investigate the mutated gene in a Chinese family with an autosomal dominant form of DGI-II.","DSPP","Heterozygous deletion in intron 2 (IVS2-3C→A)","AD","Haplotype analysis, DNA sequencing, allele-specific sequencing, DHPLC","Did not have bilateral progressive high-frequency sensorineural hearing loss (a feature seen in some DGI types)","NA","NA"]
["10.1016/j.ijporl.2008.11.010","Joseph & Rasool/2009","India","Non-syndromic sensorineural deafness","Mutation detection and haplotype analysis","59 families (86 affected subjects)","Not specified","Determine the prevalence of GJB2 mutations and identify novel mutations in the population of Kerala, India.","GJB2","W24X, R32L (novel)","AR","Sequencing, PCR-RFLP, genotyping","Severe to profound sensorineural hearing loss","NA","NA"]
["10.1017/S0022215108002892","Khandelwal et al./2009","India","Congenital, non-syndromic, sensorineural hearing loss","Case-control study","100 patients, 100 controls","M: 59, F: 41/Mean age: 12.06 yrs","Determine the prevalence of the three most common GJB2 mutations in a North Indian population.","GJB2","35delG, W24X, 167delT","AR","PCR-RFLP assays, sequencing","Moderately severe, severe, or profound hearing loss","NA","NA"]
["10.1016/j.ijporl.2008.10.002","Fischer et al./2009","USA","Severe to profound sensorineural hearing loss in cochlear implant recipients","Retrospective case series review","14 patients of specific minority descent","M: 4, F: 10/Average age: 7 yrs","Review results of genetic evaluation in Caribbean Hispanic and African American admixture pediatric cochlear implant recipients.","GJB2","V37I, A670C, 35delG, W24X","Monoallelic, Biallelic","Retrospective review of sequencing results","Severe to profound sensorineural hearing loss","NA","NA"]
["10.1016/j.ijporl.2008.10.001","Tamayo, ML. et al. 2009","Colombia","Non-syndromic congenital sensorineural hearing loss","Pilot screening program (cross-sectional genetic study)","731 children screened; 276 detailed ophthalmological evaluation; 112 non-syndromic deafness sequenced","Children aged 4–18 years (sex not specified)","To define the prevalence of non-syndromic deafness and establish the frequency of mutations in the GJB2 gene (Cx26) in institutionalized deaf children in Bogotá","GJB2","35delG, S199F, 167delT mutations; M34T variant; V27I polymorphism","59.8% autosomal recessive, 40.2% sporadic cases","Targeted mutation testing for 35delG plus full GJB2 coding region sequencing using BigDye Terminator Cycle Sequencing Kit v3.1 (ABI PRISM 3100 Avant)","Predominantly profound bilateral SNHL; some severe and moderate cases documented; genotype–phenotype correlations reported","No dedicated vestibular testing reported; ophthalmological examination used to exclude syndromic causes","NA"]
["10.1097/GIM.0b013e318187e106","Hildebrand et al./2008","USA/ The Netherlands","Autosomal dominant sensorineural hearing loss (ADSNHL), DFNA2","Audioprofile-directed mutation screening","77 American families","Not specified","Prioritise candidate genes for mutation screening in small families with high-frequency ADSNHL using audioprofiling software.","KCNQ4","p.E260K, p.D262V, p.W241X (all novel)","AD","Audioprofiling software (AudioGene), direct sequencing","Progressive, predominantly high-frequency hearing loss","NA","NA"]
["10.1097/MLG.0b013e31817fb7ad","Angeli/2008","USA","Nonsyndromic prelingual sensorineural hearing loss (DFNB1)","Prospective cohort study","119 unrelated children","M: 19, F: 12 (DFNB1 group)/Under 17 yrs","Determine DFNB1 prevalence and study phenotype/genotype correlations in an ethnically diverse cohort.","GJB2, GJB6, mitochondrial DNA","c.35delG, del(GJB6-D13S1830), and 10 other GJB2 variants","Biallelic recessive","Mutational screening by sequencing and multiplex PCR","Ranged from mild to profound, congenital, symmetrical, and stable","Vestibular function inferred from gross motor milestone development; no formal vestibular testing.","NA"]
["10.1097/MAO.0b013e3181825651","Kallman et al./2008","USA","Autosomal dominant progressive sensorineural hearing loss (DFNA11)","Family study/Genetic modifier analysis","One large American family","Not specified","Characterise audiovestibular and retinal features in a DFNA11 family and search for genetic modifiers.","MYO7A, ATP2B2, WFS1","MYO7A G2164C (G772R)","AD","Audiometry, VEMP, EcochG, ERG, SNP analysis","Progressive low- and mid-frequency hearing loss with variable severity","Vestibular function assessed by oculomotor testing, dynamic posturography, and bithermal calorics.","Impairment may parallel hearing loss severity"]
["10.1111/j.1749-4486.2008.01754.x","Bajaj et al./2008","UK","Non-syndromic sensorineural recessive deafness in British Bangladeshis","Cross-sectional survey","53 families (67 patients)","M: 31, F: 36/Age range: 3-27 yrs","Determine the prevalence and spectrum of GJB2 mutations in prelingual deafness in the British Bangladeshi population.","GJB2","W24X, IVS1+1, M1V, W77X, Q124X","Biallelic recessive","Genetic analysis by DHPLC and direct sequencing","Prelingual sensorineural deafness (moderate to profound)","NA","NA"]
["10.1016/j.ajhg.2008.07.008","Ruel et al./2008","France/ USA/ Germany","Autosomal-dominant nonsyndromic deafness (DFNA25)","Linkage analysis and candidate gene study/Mouse model functional analysis","Two unrelated families","Not specified","Identify the gene responsible for DFNA25 and characterise inner hair cell function in null mice.","SLC17A8 (VGLUT3)","c.632C>T (p.A211V)","AD","Linkage analysis, direct sequencing, functional studies in null mice","Progressive, high-frequency sensorineural deafness","NA","NA"]
["10.1097/gim.0b013e31817d2ef1","Dai et al./2008","China","Moderate to profound sensorineural hearing loss (SNHL)","Population screening/Prevalence study","3271 unrelated subjects","M: 1879, F: 1392/Mean age: 13.84 yrs","Determine the prevalence of the common SLC26A4 c.919-2A>G mutation among various Chinese ethnic groups.","SLC26A4","c.919-2A>G (IVS7-2A>G)","AR","PCR-RFLP, direct sequencing","Moderate to profound SNHL, often with enlarged vestibular aqueduct (EVA)","Vestibular function was assessed by temporal bone CT scans to detect enlarged vestibular aqueduct (EVA).","NA"]
["10.1186/1471-2350-9-48","Evirgen et al./2008","Turkey","Congenital hearing loss","Cross-sectional genotyping study","47 hearing-impaired students","M: 28, F: 19/Age range: 8-18 yrs","Determine the prevalence of 35delG, 167delT (GJB2), and del(GJB6-D13S1830) mutations in a Turkish deaf school population.","GJB2, GJB6","35delG, 167delT, del(GJB6-D13S1830)","NS","PCR-ELISA","Congenital hearing loss","Vestibular function was assessed with VEMP and EcochG, both yielding normal results.","NA"]
["10.1089/gte.2007.0106","Bramhall et al./2008","USA","Autosomal dominant low frequency sensorineural hearing loss (LFSNHL)","Family/Genetic and audiovestibular analysis study","One American family (7 participants)","Not specified","Determine if LFSNHL in a family is linked to a WFS1 mutation and characterise the audiovestibular phenotype.","WFS1","c.2054G>C (p.R685P)","AD","Microsatellite analysis, direct sequencing, VEMP, EcochG","Bilateral, symmetric, moderate LFSNHL with slow progression","NA","NA"]
["10.1016/j.heares.2008.03.004","Matos et al./2008","Portugal/UK","Autosomal dominant hearing loss","Research paper/Family study/In vitro functional studies","3 family members, 103 controls","F: 2, M: 1/NA","Identify and characterise a novel dominant GJB2 mutation (p.M163L) in a Portuguese family with NSSHL.","GJB2, GJB6, mtDNA","p.M163L, c.35delG, del(GJB6-D13S1830), del(GJB6-D13S1854), A1555G, A7445G","AD","SSCP, PCR, direct sequencing, enzymatic restriction, microscopy, FACS","Bilateral mild/moderate high-frequency NSSHL; \"ski-slope\" hearing loss","NA","NA"]
["10.1089/gte.2007.0107","Auslender et al./2008","Israel","Usher Syndrome Type 2 (USH2)","Family/Linkage and mutation analysis study","12 unrelated Israeli Jewish families, various control panels","Not specified","Investigate the genetic basis for USH2 among Jews of various origins.","USH2A","c.239-240insGTAC, c.1000C>T, c.2209C>T, c.12067-2A>G, c.5519G>T","AR","PCR, direct sequencing, restriction endonuclease-based assays","Early onset, moderate-to-severe, stable sensorineural hearing loss, most pronounced at higher frequencies","Clinical criteria: classified as USH2 with normal vestibular function; no vestibular testing reported.","NA"]
["10.1001/archotol.134.4.403","Brownstein, ZN. et al. (2008)","Israel","Non-syndromic hearing loss and enlarged vestibular aqueduct","Experimental Design (audiometric analysis)",514,"N/A","To screen possible mutations in the SLC36A4 gene in patients with hearing loss and enlarged vestibular aqueduc","SLC26A4","c.1458_1459insT","AR","Sequencing","Progressive hearing loss","Diagnosis based on CT-confirmed enlarged vestibular aqueduct; no vestibular function testing reported.","NA"]
["10.1001/archotol.134.3.294","Pauw, RJ. et al. (2008)","Netherlands","Presbycusis","Experimental Design (Audiometric analysis)",60,"Both/35","To investigate audiological and vestibular features of a family with a mutation in the POU4F3 gene","POU4F3","p.L289F","AD","Sequencing analysis","NA","Two symptomatic carriers underwent rotatory vestibulo-ocular reflex tests; results showed labyrinth hypofunction.","Hypofunction of vestibular labyrinth"]
["10.1002/ajmg.a.32078","Doherty, ES. et al (2007)","United States of America","Muenke syndrome","Experimental Design (Audiometric analysis)",9,"Both/5 patients (18-43 months), 4 patients (31-67 years)","To investigate the audiological and developmental assessment of 9 patients with Muneke syndrome with the mutation in FGFR3 ","FGFR3","Pro250Arg","AD","Sequencing analysis","Mild-to-moderate, low frequency hearing loss","NA","NA"]
["10.1111/j.1399-0004.2007.00833.x","Wagatsuma, M. et al (2007)","Japan","Non-syndromic hearing loss","Experimental Design (Audiometric analysis)",210,"Both/8-48 years","To find the prevalence of nonsyndromic hearing loss in japanese patients with a mutation in CDH23","CDH23","719 C>T, 902G>A, 5147A>C, 6085C>T, 4249C>T, 5131G>A, 5419G>A, 5627G>A, 5722G>A,  6511C>T, 6680A>C, 6847G>A, 7418T>C, 7466G>A, 8005A>G, 8401T>G, 9523C>T","AR","sequencing","high frequency hearing loss","Caloric test, posturography, and ocular motor examination confirmed normal vestibular function in patients.","NA"]
["10.1002/ajmg.a.31718","Meyer, NC. et al (2007)","Iran","Non-syndromic hearing loss","Experimental Design (Audiometric analysis)","45 families with 100 controls","Both/NA","Mutation screening of 45 families and investigating the audiological assessment of patients with mutation in TECTA genes","TECTA","266delT, 5211C > A, removal of Exon 10","AR","Sequencing","moderate to severe hearing loss","NA","NA"]
["10.1097/gim.0b013e3180a03276","Putcha, GV. Et al (2007)","North America","Nonsyndrromic SNHL","Experimental Design (ethnic and frequency analysis)",7401,"Both/NA","Mutation screening and and finding the prevalence of frequencies of the mutations in North American cohort","GJB2 and GJB6","35delG","AR","sequencing","Mild-Severe","NA","NA"]
["10.1186/1471-2350-8-26","Tsai, HT. et al (2007)","Taiwan","Nonsyndromic hearing loss","Experimental Design (Audiometric analysis)",10,"Both/NA","To investigate audiological features of a family with a mutation in WFS1 gene","WFS1","2005T>C","AD","Direct sequencing","low frequency","NA","NA"]
["10.1007/s10162-006-0060-9","Plantinga, RF. Et al (2006)","Netherlands","Nonsyndromic hearing loss","Experimental Design (Audiometric analysis)",5,"Both/35.6","To investigate audiological features of a family with a mutation in TECTA gene","TECTA","R1890C","AD","NA","mid frequency","NA","NA"]
["10.1111/j.1399-0004.2007.00739.x","Kitajiri, S. et al (2007)","North America","Nonsyndromic hearing loss","Experimental Design (Audiometric analysis)",8,"Both/38","To investigate audiological features of a family with a mutation in TMC1 gene","TMC1","p.D572H (c.G1714C)","AD","Genomic analysis and sanger sequencing","initially high frequency and then deteriates to high frequency","Vestibular function assessed by tandem gait, Romberg testing, and locomotor developmental history review.","NA"]
["10.1007/s10038-007-0144-3","Fukuoka, H. et al (2007)","Japan","Nonsyndromic hearing loss","Experimental Design (Audiometric analysis)",356,"Both/NA","To investigate whether WFS1 mutations occur only in patients with low frequency SNHL and what kinds of WFS1 mutations are present in Japanese cohort","WFS1","c.2146G > A, \t\nc.2590G > A","AR","Direct DNA sequencing","low frequency","NA","NA"]
["10.1007/BF02935334","Sirmaci A, Akcayoz-Duman D, Tekin M (2006)","Turkey","SNHL","Experimental Design (Screening analysis)",295,"Both/NA","To investigate the prevalence of two large deletions del(GJB6-D13S1830) and del(GJB6-D13S1854) and determine the distribution across Anatolia ","GJB2 and GJB6","c.IVS1+1G>A","AR","Sanger Sequencing","moderate to profound","NA","NA"]
["10.1002/ajmg.a.31525","Tang, Hsiao-Yuan. et al (2006)","United States of America","SNHL","Experimental Design (Screening analysis)",904,"NA","Sequence the GJB2 gene in 610 patients with hearing impaierment and a multi ethnic control group ","GJB2  ","G4D, T123N, V37I, R127L, V207L","AR","DNA sequence analysis","NA","NA","NA"]
["10.1136/jmg.2006.041954","Seeman P, Skmaryova (2006)","Czech republic","Non-syndromic hearing loss","Experimental Design (Screening analysis)",242,"NA","The prevalence of the splice site mutation IVS1+1G in czech republic population with prelingual nonsyndromic hearing loss","GJB2","IVS1 + 1 G","AR","DNA sequence analysis","NA","Diagnosis based on congenital profound deafness, vestibular dysfunction, and retinal degeneration; no separate vestibular tests.","NA"]
["10.1136/jmg.2005.034892","Eiberg,  H.et al (2006)","Denmark","hearing loss","Experimental Design (Audiometric analysis)",17,"Both/NA","Genetically screenfor mutation analysis in WFS1, OPA1, OPA3, OPA4, OPA5, GJB2, GJB6","WFS1","E864K, c.2590G>A","AD","Sequencing","low frequency","Diagnosis of USH1 included congenital profound deafness and vestibular dysfunction; no additional vestibular testing.","NA"]
["10.1002/humu.9044","Kupka, S. et al (2002)","German","Hearing loss","Experimental Design (Audiometric analysis)",342,"NA","to screen for genetic. Mutations in the GJB2 gene in the german population","GJB2  ","I82M, 313del14","AR","DNA sequence analysis","NA","Caloric vestibular testing performed in a selected subgroup of patients.","NA"]
["10.1038/sj.ejhg.5200826","Frei, K. et al (2002)","Austria","SNHL","Experimental Design (Audiometric analysis)",57,"NA","To screen for genetic mutation in the GJB2 gene for austrian population, and its prevalence","GJB2","A88S","AR","Direct DNA sequencing","NA","NA","NA"]
["10.1007/s00439-002-0719-1","Cryns, K. et al (2001)","United states and Europe","SNHL","Experimental Design (Audiometric analysis)","66 families and sporadic cases, and between 82 and 184 controls","NA","Do a mutation screen of the patients in the WFS1 gene","WFS1","2419A>C, 20196C>T, 2492G>G, 2300-2302delTCA, 2021G>A, 2021G>T, 577A>G","AD","Genomic exon sequencing","low frequency","NA","NA"]
["10.1002/humu.9033","Najmabadi, H. et al (2002)","Iran","SNHL","Experimental Design (Audiometric analysis)",168,"NA","Do a mutation screen and assess the prevalence of Autosomal recessive mutations of the GJB2 gene in Iranian patients","GJB2","35delG/35delG, R184P/-3170G>A, 35delG/-3170G>A, 35delG/W24X, W24X/W24X, 35delG/-3170G>A","AR","DNA sequence analysis","NA","NA","NA"]
["10.1177/000348940211100312","Leenheer, EMRD. et al (2002)","Netherlands","Hearing loss","Experimental Design (Audiometric analysis)",86,"NA","Do an audiological analysis on patients with KCNQ4 related hearing loss with missense mutation in W276S in Dutch patients","KCNQ4","W276S","AD","NA","high frequency hearing loss","Rotatory and caloric stimulation with electronystagmography in 11 mutation carriers.","Motion sickness"]
["10.1002/humu.10049","Brederlow, BV. et al (2002)","Germany and switzerland","SNHL","Experimental Design (Screening analysis)",33,"Both/NA","Do a mutation screening analysis of patients with  usher syndrome type 1D","CDH23","c.6933delT, c.5712G>A, and IVS45-9G>A, IVS51+5G>A","AR","Single strand conformation polymorphosim analysis","NA","Clinical examination; vestibular dysfunction noted, but no formal vestibular tests performed.","Severe vestibular dysfunction"]
["10.1007/s100380200057","Komatsu, K. et al (2002)","Japan","SNHL","Experimental Design (Screening analysis)",42,"Both/NA","To genetically screen a family with low frequency SNHL ","WFS1","K634T","AD","Genome wide linkage analysis","Low frequency","NA","NA"]
["10.1093/hmg/10.22.2501","Bespalova, IN. et al (2001)","Netherlands and United states of america","SNHL","Experimental Design (Screening analysis)","4 families","Both/NA","Analyse the frequency of WFS1 gene mutation in low frequency hearing loss, and find the causal mutation ","WFS1","T699M, A716T, V779M, L829P, G831D","AD","DNA sequencing","low frequency","NA","NA"]
["10.1001/archotol.127.9.1037","Kenna, MA. et al (2001)","Unitted States of America","SNHL","Experimental Design (Audiometric analysis)",107,"Both /between 1 week to 16 years old","To screen the mutations in GJB2 gene in children patients with SNHL or mixed hearing loss ","GJB2","35delG, 167delT, E47X, L90P, M34T, G12V, V37I, R143W, V84L, V153I, V27I, and 310del14, and novel mutations E129K, T8M, and N206S","AR","Sequencing analysis","unilateral high frequency SNHL to bilateral profound SNHL","NA","NA"]
["10.1001/archotol.127.9.1037","Dahl, HH. et al (2001)","Australia","Hearing loss","Experimental Design (Audiometric analysis)",243,"Both/4 years","To screen for the prevalence of genetic mutations in GJB2 gene affecting australian children with non-syndromic hearing loss","GJB2","135S, C53R, T123N and R127C being novel and 35delG, V371I, M34T, L90P, M34T, C53R, W24X, 167delT, W77R, R143W, R184W, I35S, 333-334e3lQQ","AR","DNA sequencing","high frequency hearing loss, mild-severe","NA","NA"]
["10.1002/humu.37","Kamarinos, M. et al (2001)","Australia","Hearing loss","Experimental Design (Audiometric analysis)","13 affected individuals","NA","To identify the causitive gene mutation in the australian family with dominant late onset hearing loss, and assess audiological data of these affected family members","COCH","I109N","AD","Genetic analysis","High frequency, severe to profound hearing loss","Clinical history, symptom assessment, reports of imbalance, unsteadiness, oscillopsia; no formal vestibular tests.","Vertigo"]
["10.1038/sj.ejhg.5200607","Loffler, J. et al (2001)","Austria","SNHL","Experimental Design (Audiometric analysis)",92,"NA","To identify the prevalence of the mutations in GJB2 gene causing SNHL in population of Austria","GJB2","35delG, L90P, 314del14, V84L, IVS1+G>A, R127H, G160S, G150S and 3 novel mutations, R143Q, I20T, Y155X","AR","Genomic analysis ","mild to profound","NA","NA"]
["10.1001/archotol.127.1.13","Leenheer, EMRD. et al (2001)","United States of America","SNHL","Experimental Design (Audiometric analysis)",67,"Both/NA","To audiologically assess the patients from 5 families who have a genetic mutation in the COL11A2","COL11A2","exon 42 C>T","AD","Genomic analysis","midfrequency","NA","NA"]
["10.1086/316954","Bork, JM. et al (2001)","Pakistan, India, and Turkey","SNHL","Experimental Design (Audiometric analysis)","13 families","Both/NA","To identify the gene responsible for DFNB12 by sequencing candiate genes and discoveering mutations in the CDH23 gene","CDH23","Q492X, IVS23+1G>A, D1243N, R1305X, D1400N, D188N, I2148N, R2154C, P2257T, IVS44+1G>A","AR","Sequencing analysis","profound hearing loss","Clinical exams, funduscopy, motor milestone history, tandem-gait, Romberg, and electroretinography for vestibular dysfunction.","NA"]
["10.1097/00005537-200008000-00030","Khetarpal, U (2009)","United States of America","Hearing loss","Experimental Design (Audiometric analysis)","1 family","NA","To find vestibular abnormalities in an american family with mutation in the COCH gene","COCH","V66G, G88E, W117R and P51S","AD","NA","Progressive, high frequeny","ENG, sinusoidal rotation, and static/dynamic posturography used to assess vestibular dysfunction.","vertigo, mild-moderate ataxia"]
["10.1076/1381-6810(200006)2121-8FT123","Beneyto, M. et al (2000)","Spain","SNHL","Experimental Design (Screening analysis)","59 families","NA","To investigate the prevalence of the 2314delgG mutation in USH2A gene who have usher syndrome","USH2A","2314delG","AR","Sequencing analysis"," moderate-severe, non progressive hearing loss","Vestibular function assessed clinically; USH2 patients showed normal vestibular responses, no dysfunction reported.","NA"]
["10.1001/archotol.126.5.633","Frydman, M. et al (2000)","Israel","SNHL","Experimental Design (Audiometric analysis)",23,"NA","To assess the the audiological characteristics of hearing loss associated with the mutation in the POU4F3","POU4F3","884del8","AD","Mutational analysis","Progressive","NA","NA"]
["10.1007/s004390000273","Wilcox, SA. et al (2000)","United states of America","Hearing loss","Experimental Design (Audiometric analysis)","126 children","NA","To do a mutational analysis of the GJB2 gene in children, and characterise the type of hearing loss they experience","GJB2","V37I, M34T, R184W, 35delG, 167delT, L90P","AR","Sequencing analysis","high frequency hearing loss, mild to profound","NA","NA"]
["10.1097/00005537-200003000-00025","Admiraal, RJC. et al (2009)","Netherlands","SNHL","Experimental Design (Audiometric analysis)","15 affected","Both/NA","To assess the hearing impairment of patients with Stickler syndrome with a mutation in the COL11A2 gene","COL11A2","in frame skipping of a 54-bp exon at the splice donor site","AD","close linkage analysis","high frequency","NA","NA"]
["10.1002/(sici)1096-8628(20000117)90:2<141::aid-ajmg10>3.0.co;2-g","Kudo, T. et al (2000)","Japan","Prelingual deafness ","Experimental Design (Screening analysis)",165,"Both/NA","Do a mutational screening of the GJB2 gene in Japanese population ","GJB2","235delC, 176-191 del (16), Y136X novel mutation and other described mutations V27I, V37I, E114G, and I203T","AR","sequencing analysis","low-high frequency hearing loss and profound","NA","NA"]
["10.1007/s004390051007","Rabionet, R. et al (1999)","Italy and Spain","Hearing loss","Experimental Design (Screening analysis)","576 families (1152 chromosomes analysed)","NA","To assess the prevalence of the GJB2 gene mutations from Italy and Spain","GJB2","4 mutations were novel G12V, S19T, E114X, delE120, 4 mutations were found in the report but were also found in other studies L90P, 312del114, 334delAA, delE120, and the 14 were found in the other studies M1V, 35delG, 35insG, W24X, M34T, V37I, E47X, 167delT,Y65X, W77R, F83L, R127H, R143W, R184P","AR","Sequencing analysis ","NA","NA","NA"]
["10.1002/1098-1004(200007)16:1<7::AID-HUMU2>3.0.CO;2-A","Antoniadi, T. et al (2000)","Greek","SNHL","Experimental Design (Screening analysis)",26,"NA","To assess the prevalence of the GJB2 gene mutation in Greek patients with hearing loss","GJB2","1 novel gene mutation K224Q and 3 identified from previous studies 35delG, R127H, R184P","AR","Direct sequencing analysis ","NA","NA","NA"]
["10.3109/03005369909090112","Orzan, E. et al. (2009)","Italy ","Hearing loss","Experimental Design (Screening analysis, audiometric)",94,"NA/age range 3-26 years","To assess the prevalence of gene mutations in GJB2 in Italian patients with SNHL","GJB2","35delG, Q47X, IVS+1G>A, R184P, 31del14, L90P, 167delT, M34T, delE118","AR","Direct sequencing analysis","All frequencies","NA","NA"]
["10.1097/00005537-199909000-00031","Bom, SJH. et al (2009)","Netheralands","hearing loss","Experimental Design (Audiometric, and vestibular analysis)",200,"Both/NA","To examine the auditory and vestibular performance of Dutch patients with a 208C>T mutation in the COCH gene","COCH","208C>T","AD","mutational analysis","Profound hearing loss","Caloric tests, velocity-step rotatory chair, vestibulo-ocular reflex, and cervico-ocular reflex measurements.","Severe vestibular hyporeflexia "]
["10.1093/hmg/8.8.1425","Fransen, E. et al (1999)","Netherlands","SNHL","Experimental Design (Screening analysis)","23 family members","Both/NA","To do a mutational analysis in patients with with progressive SNHL and vestibular dysfunction","COCH","P51S","AD","Mutational analysis","high frequency, severe to profound hearing loss","NA","Vestibular areflexia, vertigo"]
["10.1001/jama.281.23.2211","Green, GE. et al (1999)","United States of America","Hearing loss","Experimental Design (Screening analysis)",52,"Both/NA","To assess the prevalence of the mutation in patients with mutations in GJB2","GJB2","35delG, 167delT, 269^270insT, W44X, W77R, K122I, IVS1+1G>A, S199F, M34T, H100Y, R98Q","AR","Direct sequencing","profound at all frequencies, moderate to severe ","NA","NA"]
["10.1002/(SICI)1098-1004(199912)14:6<493::AID-HUMU8>3.0.CO;2-P","Talebizadeh, Z. et al (1999)","United States of America","hearing loss","Experimental Design (Screening analysis)",170,"NA","To identify and characterise a novel gene mutation in KCNQ4 gene in a large family with dominant progressive hearing loss","KCNQ4"," L281S","AD","Direct sequencing","progressive hearing loss","NA","NA"]
["10.1006/mcpr.1997.0149","Wang, C. et al (1998)","India","Hearing loss","Experimental Design (Screening analysis)",23,"NA","To assess a family with Waardenburg Syndrome type 2 and determine if the PAX3 gene variant is associated with the disease","PAX3","T315K","AD","Sequencing","NA","NA","NA"]
["10.1002/(SICI)1098-1004(1998)11:5<387::AID-HUMU6>3.0.CO;2-8","Scott, DA. et al (1999)","India, Dominican/Puerto Rico, Israel","SNHL","Experimental Design (Screening analysis)","7 families","Both/NA","To assess GJB2 mutations in autosomal recessive, nonsyndromic hearing loss at DFNB1 locus","GJB2","Gdel35, W24X, W77X, Q123X","AR","Direct sequencing","congenital, severe to profound ","NA","NA"]
["10.1097/00005537-199607000-00021","Lalwani, K. et al (1996)","United States of America","Hearing loss","Experimental Design (Screening analysis)","24 families (39 affected)","NA","First report in homeobox mutations in the gene PAX3 causing Waardenburg Syndrome type 1","PAX3","T315K","AD","Sanger Sequencing","unilateral profound, bilateral profound","NA","NA"]
["10.1080/00016489.2025.2479632","Li, Y. et al (2025)","China","SNHL","Experimental Design (Screening analysis for humans, knock in phenotyping for mice)","8 affected members","NA for humans, mice ABR 4-5 weeks","To test the pathogenecity of MYO15A by creating a mouse mouse knock in model, and then assessing hair-cell morphology/function and hearing","MYO15A","c.2482C>T in Uygur family, c.2455A>T to test mechanism","AR","Sanger Sequencing","profound in humans and mice","NA","NA"]
["10.3390/genes15111451","Alsebeyi, M. et al (2024)","United Arab Emirates","SNHL","Experimental Design (Screening analysis)","1 family","NA","To identify the genetic basis of ARNSHL in Emirati family using clinical exome sequencing","CDH23","264G>A, 5168G>A","AR","Exome sequencing","Severe to profound SNHL","NA","NA"]
["10.1002/ohn.1200","Wang, Y. et al (2025)","China","SNHL","Experimental Design (Screening analysis and audiometric analysis)","16 patients from 14 pedigrees","Both/NA","Determine hearing loss phenotypes caused by MYO15A variants","MYO15A","5 novel c.3660_3666delinsAA (p.Glu1221fs), c.4635delG (p.Val1545fs), c.6664A>G (p.Met2222Val), c.8215delG (p.Ala2739fs), c.8897delG (p.Gly2966fs).  And 1 recurrent c.3524dupA","AR","Next generation sequencing","moderate to profound hearing loss","NA","NA"]
["10.1016/j.gene.2023.147335","Lee, SJ. Et al (2023)","Korea","SNHL","Experimental Design (Screening analysis and structural modeling)","8 families and 8 probands","Both/ages ranged from 5 to 41 years","To determine structural impacts of TMPRSS3 variants on protein stability and function, and evaluate genotype to phenotype correlations","TMPRSS3","Seven mutant alleles were found: p.Arg109Trp, p.Val116Met, p.Tyr137Ter (novel), p.Thr248Met, c.783-1G>A (splice), p.Ala306Thr, p.Ala387Thr","AR","Sanger sequencing","prelingual profound, progressive residual low-frequency hearing loss","NA","NA"]
[" 10.1186/s12920-024-02023-1","Du, Q. et al (2024)","China","SNHL","Experimental Design (Screening analysis)","3 families","Both/NA","To characterise FGF3 variants in families with LAMM syndrome","FGF3","c.137G>C (p.Arg46Pro)","AR","Sanger Sequencing","profound","MRI and CT showed labyrinthine aplasia; ABR/ASSR confirmed absent vestibular function.","labyrinthine aplasia"]
["10.46903/gjms/21.02.1189","Ukaegbu, M. et al (2023)","Nigeria","SNHL","Experimental Design (Screening analysis)","150 patients with non-syndromic SNHL and 20 controls. Sequencing performed on 78 samples","Both/NA","To determine the distribution of non-syndromic SNHL in Nigeria, and the role of GJB2 and GJB6 mutations","GJB2 and GJB6","p.Leu56His (L56H) and (del(GJB6-D13S1830), del(GJB6-D13S1854))","AR","Sanger Sequencing","Moderately severe to profound, high frequency","NA","NA"]
["10.3390/jcm11071837","Kraatari-Tiri, M. et al (2022)","Finland","SNHL","Experimental Design (Screening analysis)","11 affected patients from 8 families","Both/age range of 0-57 years","To characterise phenotypes and genetic variants of patients of Finland with TMC1 associated hearing loss","TMC1","c.1534C>T (p.Arg512), c.968A>G (p.Tyr323Cys, novel); c.1763+3A>G (splice site), c.1714G>A (p.Asp572Asn)","AR and AD","Sanger Sequencing","Congenital, profound, high frequency","NA","balance issue"]
["10.26650/IUITFD.1011501","Güleç, Ç. Et al  (2022)","Turkey","Hearing loss","Experimental Design (Screening analysis)",402,"Both/NA","To characaterise frequency of GJB2 variants in a Turkish patients with SNHL","GJB2","c.35delG, c.71G>A, c.-23+1G>A, c.233delC, c.358_360delGAG, c.150C>A (p.Asp50Glu), c.150C>A (p.Asp50Glu)","AR","Sanger Sequencing","Profound, progressive, congenital","NA","NA"]
["10.3389/fgene.2021.643546","Zhang, S. et al (2021)","China","SNHL","Experimental Design (Screening analysis)",23,"Both/NA","To ifentify genetic cause of Waardenburg syndrome in Chinese families","PAX3, SOX10, MITF","c.1459C>T (p.Gln487Ter), c.123del, c.959-409_1173+3402del, c.198_262del, c.529_556del, c.731G>A (p.Gly244Glu), c.970dup","AD","Next generation sequencing","Profound","NA","NA"]
["10.1159/000513607","Li, Y. et al (2021)","China","SNHL","Experimental Design (Screening analysis)","5 affected","Both/NA","To charecterise a novel MITF gene variant in a Chine family","MITF","c.1025_1032delGGAACAAG (p.Trp342TrpfsX25)","AD","Sanger Sequencing","Congenital","NA","NA"]
["10.1134/S1022795422050106","Stepanova, AA. Et al (2021)","Georgia","SNHL","Experimental Design (Screening analysis)","39 probands and 117 health controls","Both/age range from 5-18 years old","To investigate the spectrum of GJB2 mutations and assess the cause of other common hearing loss gene in Georgian patients with SNHL","GJB2","c.35delG, c.358_360delGAG, c.–23+1G>A, c.551G>C","AR","Sanger Sequencing","Severe","NA","NA"]
["10.3390/genes10100735","Maekawa, K. et al (2019)","Japan","SNHL","Experimental Design (Screening analysis)","8074 probands, 28 affected individuals","Both/age of onset 0-36 years (6.1 years mean)","Screen a large Japanese cohort to find LOXHD1 variants and describe the clinical manifistations","LOXHD1","c.4212+1G>A, c.3281A>G, c.5885C>T, c.3857G>T, c.246 − 1G > A, c.5869G > T, c.4213 − 1G > A, c.4375 + 1G > T, c.3076G > T, c.6168delC, c.4734C > G, c.5734G > A, c.3578C > T, c.6037G > A, c.5933G > A, c.5608C > T, 1270 + 4A > C, c.5086 − 3C > A, c.2726C > T, c.1828G > A","AR","Sanger Sequencing","mild-profound","cVEMP, oVEMP, and caloric testing performed in subset; all showed normal vestibular function.","NA"]
["10.1038/s41431-021-00820-1","Nash, BM. Et al (2021)","Filipino/Australian, New Zealand/European","SNHL","Experimental Design (Screening analysis)","17 affected","Both/NA","To report two families with autosomal dominant COL9A3 variants","COL9A3","c.1107+1G>C, c.388G>A (p.Gly130Ser)","AD","Sanger Sequencing","Mild-moderate","NA","NA"]
["10.3390/genes11101233","Buonfiglio, P. et al (2020)","Argentina","SNHL","Experimental Design (Screening analysis)","600 probands","Both/NA","To identify the causes of mutations in GJB2/GJB6 in an Argentinian patients with NSHL","GJB2 and GJB6","For GJB2 c.35delG, p.Val27Ile, p.Met34Thr, c.167delT, For GJB6  del(D13S1830) and del(D13S1854)","AR","Sanger Sequencing","moderate to profound","NA","NA"]
["10.3390/ijms20174174","Lee, SY. Et al (2019)","Korea","SNHL","Experimental Design (Screening analysis and haplotype study)","4 families an 5 affected","Both/5 months to 4 years","To identify PDZD7 variants causing NSHL in Korean families","PDZD7","Three novel variants: c.490C>T (p.Arg164Trp), c.1669delC (p.Arg557Glyfs*13), c.1526G>A (p.Gly509Glu), p.Arg164Trp in trans with p.Arg557Glyfs*13 or p.Gly509Glu in two families.","AR","Exome sequencing","moderate-severe","Vestibular function assessed clinically; no nystagmus, balance disorder, or inner ear anomalies observed.","NA"]
["10.14715/cmb/2019.65.3.12","Xiao, SY. Et al (2019)","China","SNHL","Experimental Design (Bioinformatic analysis)","3 affected and 9 unaffected","Both/NA","Identify the cause autosomal dominant hearing loss in a Chinese family","EYA4","c.1855T>G (p.W619G)","AD","Sanger Sequencing","Progressive, mid frequency SNHL","NA","NA"]
["10.5152/TurkPediatriArs.2017.4254","Subaşıoğlu, A. et al (2017)","Turkey","Hearing loss","Experimental Design (Screening analysis)","21 families with 122 individuals and 62 affected","Both/NA","To identify the cause of hearing loss in Turkish families","GJB2, TMIE, OTOF, TMPRSS3, TMHS","c.35delG c.-23+1G>A,  c.457G>A (p.V153I), c.507C>A (p.C169). TMIE c.250C>T (p.R84W) ","AR","Sanger Sequencing","Mild to profound ","Vestibular evaluation included caloric testing; vestibular dysfunction identified in affected family members.","NA"]
["10.1590/1678-4685-gmb-2017-0318","Xia, H. et al (2019)","China","Hearing loss","Experimental Design (Screening analysis)","1 affected male, parents, and 200 controls ","Both/(mean age 27+6.8 years)","To investigate the genetics of hearing loss in Chinese patients","GJB2","c.235delC (p.L79Cfs*3)","AR","Exome sequencing","Profound","Vestibular function not directly tested; auditory evaluation included ABR, OAE, and MRI imaging.","NA"]
["10.1155/2016/5310192","Gu, X. et al (2016)","China","SNHL","Experimental Design (Screening analysis)","7 affected members","Both/NA","To determine the genetic basis of hearing loss in Chinese family ","COCH","c.T275A p.V92D","AD","Sanger Sequencing","Progressive","Vestibular function assessed by caloric testing and electronystagmography in affected family members.","NA"]
["10.1371/journal.pone.0129662","Huang, S. et al (2015)","China","Hearing loss","Experimental Design (Screening analysis)","3864 with SNHL and 600 controls","Both/NA","To determine if the GJB2 variant is pathogenic and its hearing phenotypes associated with SNHL","GJB2","p.V37I","AR","Direct sequencing","mild-profound","NA","NA"]
["10.1186/s12881-016-0269-3","Ryu, N. et al (2016)","Korea","Hearing loss","Experimental Design (Screening analysis)","87 affected patients, 100 controls","NA","To determine if SLC17A8 variants contribute to hearing loss in Korean patients","SLC17A8","c.616dupA, c.232A>G, c.1120G>T, c.171G>A","AD","Sanger Sequencing","High frequency, progressive","NA","NA"]
["10.4103/1012-5574.152707","Barbary, NE. et al (2014)","Egypt","SNHL","Experimental Design (Screening analysis)","51 from 40 families","Both/3months-24 years range (mean 5.4+4.1 years)","To determine the frequency of GJB2 35delG and 167delT mutations in Egyptian patiants with SNHL","GJB2","35delG, 167delT","AR","Targeted sequencing","severe-profound","NA","NA"]
["https://www.scopus.com/pages/publications/84981190748?inward","Ben-Rebeh. Et al (2016)","Tunisia","Hearing loss","Experimental Design (Screening analysis)","4 families, 28 patients examined","Both/NA","To identifiy the mutations in USH1 that cause the SNHL in Tunisian patients","MYO7A, USH1C, PCDH15","MYO7A: c.470+1G>A, c.1845delG → p.Lys615Asnfs*6; USH1C: c.7C>T (p.Arg3X); c.400C>T (p.Arg134X)","AR","Sanger Sequencing","Profound","Vestibular dysfunction evaluated using caloric testing; balance problems and delayed motor milestones noted.","balance problems"]
["10.3906/biy-1012-174","Biyikli, AT. (2012)","Turkey","Hearing loss","Experimental Design (Screening analysis)","173 patients","Both/NA","Determine the prevalence of IVS1(+1)G>A and 35delG mutation in Turkish patients with hearing loss","GJB2","IVS1(+1)G>A, 35delG","AR","Sanger Sequencing","Severe-profound","NA","NA"]
["10.1002/ajmg.a.36068","Yongchuan, C. et al (2013)","China","Hearing loss","Experimental Design (Screening analysis)","330 children","NA/SNHL: mean age 12.1 years; EVA: mean age 3.2 years","To determine the prevalence of SLC26A4 mutations in childhood SNHL and the mutation spectrum of SLC26A4 in East China","SLC26A4","c.919-2A>G, p.R409H","AR","Sanger Sequencing","Severe to Profound","High-resolution CT scanning to diagnose enlarged vestibular aqueduct (EVA).","Enlarged vestibular aqueduct"]
["10.3889/MJMS.1857-5773.2013.0287","Meguid, N. et al (2013)","Egypt","SNHL","Experimental Design (Screening analysis, audiometric analysis)",78,"Both/age range 1-15 years old","To determine the frequency of the novel GJB2 mutation in Egyptian children who have SNHL","GJB2","c.59delT","AR","Direct DNA sequencing","Mild-Severe","NA","NA"]
["10.4103/0971-7749.94491","Nayyar, SS. Et al (2011)","India","SNHL","Experimental Design (Screening analysis)",27,"Both/age range: 1-23 years (mean 7.6 years)","To determine the association between the GJB2 W24X mutation with Indian population who have SNHL","GJB2","W24X","AR","Sanger Sequencing","congenital, severe to profound ","NA","NA"]
["10.1371/journal.pone.0021665","Rodriguez-Paris, J. et al (2011)","Mixed/Colombian","SNHL","Experimental Design (Screening analysis)","5 probands and 3 controls","Both/NA","To determine whether the smaller deletion supresses GJB2 expression in cis, explaining hearing oss in individuals with GJB2 mutation in trans","GJB2, GJB6","GJB6: del(GJB6-D13S1830), del(GJB6-D13S1854); GJB2: Ser199Phe (596C>T), Gln80Pro (239A>C), 35delG","AR","Sanger sequencing","Moderate to profound","NA","NA"]
["10.1002/ajmg.a.36017","Vona, B. et al (2013)","Conducted at German university","Hearing loss","Experimental Design (Screening analysis)",10,"NA","To confirm the gene for DFNA28 as GRHL2 by identifying a secon pathogenic variant","GRHL2","c.1258-1G>A","AD","Sanger Sequencing","progressive, high frequency","NA","NA"]
["https://www.scopus.com/pages/publications/79551708550?inward","Aparisi, MJ. Et al (2010)","Spain","SNHL","Experimental Design (Screening analysis)",33,"Both/NA","To investigate a gene mutation inside USH1C to determine its pathological effect on Spanish patients with Usher Syndrome","USH1C","p.C224X and p.D124TfsX7","AR","Direct sequencing","severe to profound","Diagnosis of USH1C patients relied on clinical classification; vestibular areflexia confirmed by standard vestibular tests.","vestibular areflexia"]
["10.2478/v10046-009-0031-8","Sterna, O. et al (2009)","Latvia","Hearing loss","Experimental Design (Screening analysis)","65 affected, 79 relatives, and 7 individuals with family history of hearing loss","NA","To determine the prevalnce of the GJB2 mutations in Latvian patients with prelingual SNHL","GJB2","35delG, 311-324del14, 235delC, M34T","AR","Sequencing analysis","moderate to profound","NA","NA"]
["10.1038/ejhg.2008.30","Pera, A. et al (2008)","Spain","Hearing loss","Experimental Design (Screening analysis)","105 spaniesh patients from 47 unrelated familiies","Both/NA","To determine the mutation frequency of SLC26A4 in spanish cohort","SLC26A4","p.V88I; p.P140H; p.Q413P; p.G424D; p.T485R; and p.Q514K","AR","Sanger Sequencing","moderate-profound","Temporal bone CT used to diagnose EVA/Mondini; no functional vestibular tests reported.","Enlarged vestibular aqueduct"]
["10.1007/s00109-005-0719-4","Kalay, E. et al (2005)","Turkey","SNHL","Experimental Design (Screening analysis)","6 individuals affected across 2 families, 249 and 200 Dutch controls, and 64 unrelated Turkish deaf families ","NA/median age is 18 years for those affected","To identify the causal gene that is present in these Turkish families that cause SNHL","USH1G","c.1373A>T (p.Asp458Val; D458V)","AR","Sanger Sequencing","prelingual progound, moderate and severe","Romberg test and questionnaire on balance, motor milestones, and motion sickness.","NA"]
["10.1002/ajmg.a.30980","Street, VA. Et al (2005)","United States of America","SNHL","Experimental Design (Screening analysis)","2 affected and 1 unaffected, 206 unrelated chromosomes","Both/44 years old","Characterise the audiotry and vestibular phenotype of patients that have a COCH mutation","COCH","C542F","AD","Genome wide linkage analysis","high frequency, progressive","Videonystagmography, rotational chair, caloric testing, VEMP, posturography, and head thrust tests.","bilateral weakness, progressive horizontal semicircular canal hypofunction"]
["10.1016/j.heares.2005.08.001","Gazzaz, B. et al (2005)","Morocco","Hearing loss","Experimental Design (Screening analysis)","116 families, 200 controls","NA","To determine the prevalence of GJB2 mutations in Moroccon patients with hearing loss","GJB2","35delG","AR","Sanger Sequencing","congenital, mild to profound","NA","NA"]
["10.1038/sj.ejhg.5201491","Hansen, L. et al (2005)","Denmark","SNHL","Experimental Design (Screening analysis)","7 families, and 10 patients, with 60 controls","Both, NA","To determine the genotype to phenotype relationship in a Danish family with WFS1 mutations","WFS1","Novel: Q194X, H313Y, L313fsX360, F883fsX951. Previously reported: A133T, L543R, V415del, F883fsX950","AR","Bidirectional Sanger ","congenital profound, high frequency","NA","NA"]
["10.1080/00016480510044232","Noguchi, Y. et al (2009)","Japan","SNHL","Experimental Design (Screening analysis)","3 families, 10 subjects, 70 controls","NA","To know if the WFS1 mutations in Japanese families cause the audiological and physiological profile for autosomal dominant low frequency SNHL","WFS1","A844T","AD","Sanger Sequencing","low frequency","Clinical interview, CT imaging, auditory brainstem response; no vestibular testing performed.","NA"]
["10.1111/j.1399-0004.2005.00481.x","Bernal, S. et al (2005)","Spain","Hearing loss","Experimental Design (Screening analysis and audiometric analysis )","28 families","NA","To find the USH2A mutation in Spanish families with USH2","USH2A","6 novel pathogenic variants: p.Y506X, p.E1492X, c.944_951dup (p.Q315fs), c.1214delA (p.N405fs), c.2135delC (p.S712X), c.1551-?_2993+?del (large del exons 9–14); 4 known: c.2299delG (p.E767fs), c.2431_2432delAA (p.K811fs), c.100C>T (p.R34X), c.2276G>T (p.C759F). ","AR","Sanger Sequencing","moderate to severe hearing loss","Vestibular function assessed by electronystagmography with caloric stimulation; results normal in USH2.","NA"]
["10.1016/j.heares.2005.04.012","Dalamo, V. et al (2005)","Argentina","Hearing loss","Experimental Design (Screening analysis)","46 patients","NA","To find the prevalence of GJb2 mutations in Argentinian patients with SNHL","GJB2 and GJB6","T8M, V27I, M34T, E47X, R75W, W77R, I82M, L90P, E129K, V153I, M163V; GJB6: delGJB6-D13S1830","AR","Direct sequencing","Severe-profound","NA","NA"]
["10.1016/j.anl.2005.01.011","Asamura, K. et al (2005)","Japan and Korea","SNHL","Experimental Design (Screening analysis)","159 probands and 150 controls","NA","To determine whether mutations in COL9A3 underlies SNHL","COL9A3","p.Gly181_Pro183del, p.Asp617Glu (D617E)","AD","Sanger Sequencing","Moderate, progressive, all-frequency","NA","NA"]
["10.1111/j.1399-0004.2004.00386.x","Park, HJ. et al (2005)","Korea","SNHL","Experimental Design (Screening analysis)","26 probands, 50 controls","NA/age range from 2-25 years of age","Define the prevalence and genetic basis of SLC26A4 mutations in Korean families with EVA","SLC26A4","Recurrent: H723R, IVS7-2A>G, IVS9+3A>G, M147V, 365insT; Other: E625X, G497S, T721M, P142R, S28R, S166N, IVS4+4A>G, IVS14-1G>A, IVS15+5G>A; Novel: S28R, P142R, S166N, 365insT, E625X, IVS4+4A>G, IVS9+3A>G, IVS14-1G>A, IVS15+5G>A","AR","Sanger Sequencing","Severe to Profound","EVA diagnosed with temporal bone CT; Mondini deformity assessed radiologically.","NA"]
["10.1046/j.1529-8817.2003.00120.x","Seeman, P. et al (2005)","Czech republic","SNHL","Experimental Design (Screening analysis)","13 patients, 300 controls","NA","To determine if doule heterozygosity explains the monoallelic cases of GJB2 in Czech republican patients","GJB2, GJB6","GJB2: 35delG, Leu90Pro, 313del14 In an initial 16, three had –3170 G>A (non-coding exon 1 splice) as a second GJB2 hit and were excluded. GJB6: (Δ(GJB6-D13S1830) combined with GJB2 313del14)).","Digenic","Sanger Sequencing","Profound","NA","NA"]
["10.1111/j.1399-0004.2004.00334.x","Tekin, M. et al (2004)","Turkey","SNHL","Experimental Design (Screening analysis)","371 probands; 215 Turkey, 129 Egypt, and 136 Turkic controls","Both/NA","GJB2 mutation spectrum in Turkey, test single-origin for 35delG and del120","GJB2","3 novel: 511insAACG, T55N, 328delG. Frequent alleles include 35delG, delE120, W24X, 167delT, R143W, L90P, 299delAT, 310del14, 333–334delAA, 236–239delTGCinsAGATCCG, Y155X, R184P, R127H, V27I","AR","Sanger Sequencing and SSCP","Prelingual","NA","NA"]
["https://mednexus.org/doi/pdf/10.3760/cma.j.issn.0366-6999.2004.12.107","Xiao, Z. Xie, D. (2004)","China","SNHL","Experimental Design (Screening analysis)","131 patients, 100 controls","NA","To determine the prevalence of the mutation in GJB2 in Chinese with SNHL","GJB2","235delC, 35delG, 442G>A, 465T>A, 511G>A, and 299–300delAT","AR","Sanger Sequencing","Severe to profound","NA","NA"]
["10.1111/j.1399-0004.2004.00325.x","Wattanasirichaigoon, D. et al (2004)","Thailand","SNHL","Experimental Design (Screening analysis)","166 and 205 controls","Both/median age for hospital: 5 years; median age for college:22 years","To determine the prevalence of the variants of GJB2 gene in Thai patients with SNHL","GJB2","Known: W24X, V27I, V37I, E114G, V153I, F191L, I203T, 235delC; Novel: P87del, L89L, K98fs, F115C, W123fs, T186T, N206T.",null,"Bidirectional Sanger ","congenital, moderate to profound","NA","NA"]
["10.1016/j.heares.2004.07.001","Frei, K. et al (2004)","Austria","SNHL","Experimental Design (Screening analysis)","76 unrelated individuals; 33 families and 43 sporadic","NA","To know if digenic or monogenic patterns contribute to Hearing loss in Austria","GJB2","35delG, 269T>C, 154G>C, 682C>T, 262G>T; polymorphisms: 249C>G, 380G>A, 79G>A+341G>A, 457G>A","AR and AD","Bidirectional Sanger ","Congenital, postlingual, sporadic","Otoacoustic emissions, brainstem responses, eye-tracking, caloric tests, and temporal bone imaging.","NA"]
["10.1016/j.heares.2004.05.007","Piatto, VB. et al (2004)","Brazil","SNHL","Experimental Design (Screening analysis)","33 probands","Both/mean age 24.2 years","To determine the prevalence of gene mutation and del(GJB6-D12S1830)","GJB2","35delG, V37I; GJB6: del(GJB6-D13S1830) detected only in compound with 35delG (digenic) in 1 proband","AR","Sanger Sequencing","Profound, sevevere, moderate","Eye-tracking, spontaneous/gaze-evoked nystagmus, and caloric tests excluded vestibular dysfunction.","NA"]
["10.1097/00129492-200409000-00011","Makishima, T. et al (2004)","North America","SNHL","Experimental Design (audiometric analysis)","13 affected individuals","Both/NA","To characterise the auditory and vestibular phenotype in TMC1 D572N mutation","TMC1","p.Asp572Asn (D572N)","AD","NA","progressive, profound in all frequencies","Assessed via locomotor history, tandem gait, and Romberg testing; no formal vestibular tests performed.","Slight/isolated vertiginous symptoms"]
["10.1007/s00405-003-0679-7","Iliadou, V. et al (2004)","Greece","SNHL","Experimental Design (audiometric analysis)","107 total","Both/NA","Describe the audiological characterisitcs SNHL due to GJB2 35delG","GJB2","35delG","AR","Allele specific PCR detection","Profound, severe, high frequency","Micro-otoscopy and audiological tests performed; no vestibular abnormalities specifically assessed in this cohort.","NA"]
["10.1038/sj.ejhg.5201138","Aller, E. et al (2004)","Spain","SNHL","Experimental Design (Screening analysis)","191 unrelated patients ","Both/NA","Determine how the mutation in USH2A relates the genotype to the phenotype","USH2A","2299delG and C759F","AR","Sanger Sequencing","progressive SNHL","Electronystagmography, rotatory and caloric vestibular tests performed; results normal in tested patients.","NA"]
["10.1186/s40246-023-00489-1","Asaad, M. et al. (2023)","Yemen","SNHL","Experimental Design (Screening analysis)","2 families, 130 deaf and 50 with normal hearing","NA","Identifying the varaints that cause autosomal recessive SNHL in Yemeni families","MYO15A and OTOF","MYO15A: c.6347delA (p.Lys2116Argfs*137); OTOF: c.5292-2A>C","AR","Clinical exome sequencing","severe to profound SNHL","NA","NA"]
["10.1007/s00439-023-02581-x","Roux, I. et al. (2023)","Europe","SNHL","Experimental Design (Screening analysis)","7 families","NA","To determine whether CHD7 varaints explain the enlarged vestibular aqueduct cases wth SNHL who lack SLC26A4 alleles","CHD7","c.3553A>G; p.Met1185Val and c.5390G>C; p.Gly1797Ala","AD","Exome sequencing, Sanger sequencing","mild-moderate to severe-profound, fluctuating","Vestibular dysfunction inferred from EVA imaging; episodic vertigo and balance delay noted clinically.","NA"]
["10.1097/00129492-200501000-00009","Topsakal, V. et al (2005)","Netherlands","SNHL","Experimental Design (Screening analysis, audiometric analysis)","15 affected","NA","To test whether the phenotype alone can direct genotyping to correct autosomal dominant NSHL gene","KCNQ4","c.827G>C; p.Trp276Ser (W276S)","AD","Sequening analysis","progressive, high frequency","NA","NA"]
["10.1097/00005537-200404000-00003","Erbe, CB. et al (2009)","United States of America","SNHL","Experimental Design (Screening analysis)","68 children genotyped, 55 with analysable audiology","NA","To define the specturm of GJB2 and GJB6 mutations in pediatric NSHL","GJB2 and GJB6","GJB2: 35delG, 235delC, L90P, 167delT, M34T, 312del14, and 167delT. Novel compound het: V37I andE47X in siblings. Polymorphisms observed: V153I, V27I, V27I+E114G. GJB6: del(D13S1830)","AR","Sanger Sequencing","mild to profound","NA","NA"]
["10.1186/1471-2350-5-5","Roux, AF. Et al (2004)","France","SNHL","Experimental Design (audiometric analysis)","159 families, with a population of 6293 for 35delG and 3516 for GJB2","NA","To define DFNB1 burden in France and determinepopulation frequencines of GJb2 variants","GJB2 and GJB6","35delG, Δ(GJB6-D13S1830), E47X; New: C64X (c.192C>A), –34T>G, IVS1-12C>T; Population: 35delG, M34T; Recurrent: V37I, V27I, W24X, E47X, R127H, V153I, F83L. SNP C765T; haplotype: all 35delG and ΔGJB6 alleles on 765T","AR","Sanger Sequencing","congenital, prelingual, profound","NA","NA"]
["https://pubmed.ncbi.nlm.nih.gov/15113126/","Minarik, G. et al (2003)","Romany community in Solvakia","SNHL","Experimental Design (Screening analysis)","54 unrelated Romany patients were sequenced, 122 non-Romany and 154 romany individuals","NA","To define the spectrum and prevalence of GJB2 mutation causing NSHL in Romanies","GJB2","W24X, R127H, 35delG, V153I, L90P, V37I","AR","Sanger Sequencing ","congenital","NA","NA"]
["10.1097/00005537-200310000-00018","Lopponen, T. et al (2010)","Finland","SNHL","Experimental Design (Screening analysis)","71 children from 67 families; 313 are controls","NA","To determine the GJB2 mutation contribuation to childhood and analyse the frequencies of these mutations in Finland","GJB2","35delG, M34T, V37I, L90P","AR","Sanger Sequencing","Moderate ","NA","NA"]
["10.1001/archotol.129.8.836","Lim, LHY. Et al (2003)","United States of America","SNHL","Experimental Design (audiometric analysis)","160 children with SNHL and 49 normal hearing children","1-108 months range, 31 motnhs mean","To investigate the genotype to phenotype correlation in GJB2 mutations and SNHL in US population","GJB2","35delG, 13del14, 235delC, 269insT, 312del14, 631delGT, 167delT, Y65X, W24XP","AR","Sanger Sequencing ","Profound","Vestibular assessment included caloric testing in selected patients; most DFNB1 cases showed no vestibular dysfunction.","NA"]
["10.1034/j.1399-0004.2003.00101.x","Uyguner, O. et al (2003)","Turkey","SNHL","Experimental Design (Screening analysis)","60 families with SNHL, and 429 controls","NA","To determine the prevalence of the GJB2 mutation varaints in Turkish SNHL families","GJB2","5delG, W24X, 233delC, 120delE (355-357delGAG), R127H; novel Q80R (A239G) on same haplotype as V27I and E114G polymorphisms","AR","Direct sequencing","Bilateral non-syndromic","NA","NA"]
["10.1001/archotol.129.4.421","Pennings, RJE. Et al (2003)","Netheralands","SNHL","Experimental Design (Screening analysis)","2 families ","NA","To determine the audiometric analysis in two families with missense mutation in WFS1 gene ","WFS1","p.G674E, p.G674V","AD","Sanger Sequencing","Low frequency","Vestibular testing included electronystagmography, caloric, and rotatory chair; results were normal in examined patients.","NA"]
["10.1016/s0165-5876(02)00177-5","Pampanos, A. et al (2002)","Greek","SNHL","Experimental Design (Screening analysis)","210 patients ","NA","The prevalence and the spectrum of the mutation of GJB2 in Greeek prelingual hearing loss","GJB2","35delG, heterygotes:L90P, W24X, R184P, 291insA","AR","Sanger Sequencing","prelingual, non-syndromic, mild to profound","NA","NA"]
["10.1177/0003489415575043","Ichinose (2015)","Japan","Autosomal recessive nonsyndromic sensorineural hearing loss (SNHL) at the DFNB63 locus, associated with mutations in the LRTOMT gene.","A genetic screening study using targeted genomic enrichment and massively parallel sequencing (MPS) on a cohort of patients with mild to moderate hearing loss","106 Japanese patients with mild to moderate SNHL from unrelated, nonconsanguineous families were enrolled. From this group, one patient was identified with LRTOMT mutations. The mutations were not found in 192 normal hearing controls.","Both","To identify the genetic cause of hearing loss in a Japanese cohort using MPS and to describe the detailed clinical features, including serial audiological findings, of a patient with novel compound heterozygous mutations in the LRTOMT gene.","LRTOMT was the gene where causative mutations were identified. The screening panel included 112 genes known to cause nonsyndromic and syndromic hearing loss.","Novel compound heterozygous mutations were identified: a missense mutation c.161G>A (p.Arg54Gln) and a frameshift mutation c.565_566delT (p.Ile188ThrfsX7), both located in the LRTOMT2 protein-coding region.","AR"," Targeted genomic enrichment, massively parallel sequencing (MPS), Sanger sequencing.","Progressive, bilateral, symmetric, moderate sloping sensorineural hearing loss affecting high frequencies initially.  The patient's hearing loss progressed at 1000 Hz and higher frequencies over a six-year period.","NA","It was mentioned that the patient did not suffer from dizziness. This contrasts with mouse models where vestibular defects were observed. "]
["https://doi.org/10.1016/j.jgg.2012.11.002","Zong, L. et al (2012)","China","SNHL","Linkage study","6 families","NA","To map DFNA4 linkage; refine interval; implicate novel gene upstream MYH14","MYH14, CEACAM16, KCNA7, KCNJ14, KCNC3, KPTN, ERCC1, KCNN4","CEACAM16: 1421C>T(p.T405T), KCNA7: 922C>G(P189P); KPTN: 942C>T(P302P); ERCC1: IVS1-114G>T","AD","Genome-wide linkage","Post-lingual, progressive","Clinical vestibular exam; temporal bone HRCT normal","NA"]
["https://doi.org/10.1007/s00405-017-4699-0","Parzefall, T. et al (2017)","Austria","SNHL","Prospective genetic cohort","1 index family+ 24 Turkish families","NA","To determine causative mutations beyond heterozygous GJB2","GJB2, MYO15A","MYO15A c.5492G>T (p.Gly1831Val)","AR","Sanger Sequencing","Congenital, severe, profound","NA","NA"]
["https://doi.org/10.1016/j.ijporl.2018.01.005","Cheng, H. et al (2018)","China","SNHL","Case control verification study","26 affected, 298 cases 400 controls","NA","To identify WFS1 mutation; provide prenatal diagnosis and counseling.","WFS1","c.2389G>A (p.D797N)","AD","Sanger Sequencing","Mild to profound, post-lingual","Clinical history for vertigo; HRCT; no formal vestibular testing.","NA"]
["https://doi.org/10.1371/journal.pone.0193359","Kobayashi, M. et al (2018)","Japan","SNHL","Targeted 68-gene MPS cohort with Sanger confirmation.","2,549 probands; 19 probands; 30 affected individuals","NA","To identify prevalence, phenotype description, hotspot haplotype analysis.","WFS1","c.2507 A>C (p.K836T)","AD","Ion Torrent panel; ACMG classification","Low frequency","Chart-based symptoms; no formal vestibular testing performed.","Vertigo/dizziness"]
["https://doi.org/10.1002/lary.26528","Kasakura-Kimura, N. et al (2017)","Japan","SNHL","Retrospective case series","74/1007 probands screened","Both/NA","Assess WFS1/GJB2 prevalence; note de novo occurrences.","WFS1, GJB2","WFS1: K836T, E864K, R859P, G494S; GJB2: V37I, 235delC","AD and AR","Sanger Sequencing","Congenital, some progressive","History review; OAE/ABR subset; CT/MRI; no formal vestibular tests.","NA"]
["https://doi.org/10.1016/j.heares.2016.02.009","Jung, J. et al (2016)","South Korea","SNHL; EVA","Observational cohort",31,"Both/ (mean: 29.3 years)","To link vestibular dysfunction with genotype, anatomy, and low-frequency hearing.","SLC26A4","H723R, IVS7-2A>G; T410M, M147V, V138L, T178P, R677Afs.","AR","Exon-intron sequencing","Severe, fluctuating, progressive","Bithermal caloric VNG; CP>25% threshold; symptom history.","Unilateral CP, bilateral, dizziness"]
["https://doi.org/10.3109/14017431.2014.988172","Winbo, A. and Rydberg, A. et al (2015)","Sweden","Jervell and Lange-Nielsen Syndrome (JLNS)","Case review with interviews/vestibular testing",15,"Both/30","To assess vestibular phenotype in JLNS patients.","KCNQ1","p.R518X, p.Y111C, p.R192Cfs91X, p.M159 splice, p.Q530X, p.R190W, p.S349W, p.S227del.","AR","Genotyping by standard molecular methods","Congenital, profound","Post-rotatory nystagmus test; caloric/electronystagmography in 3 cases.","Imbalance, gross motor delay, absent PRN"]
["https://doi.org/10.1007/s00439-022-02431-2","Usami, S. et al (2022)","Japan","SNHL","Large cohort study",12139,"Both/NA","To estimate prevalence, common variants, and phenotype correlations.","CDH23","P240L, R1588W, R2029W, E956K","AR","ACMG assessment, Sanger sequencing","Congenital, profound to late onset, progressive, high frequency","Caloric test in one USH case; developmental milestones as proxy.","Vestibular dysfunction"]
["https://doi.org/10.1111/j.1399-0004.2009.01344.x","Hildebrand, M.S. et al (2010)","Iran","SNHL","Pedigree linkage/screening","1 family","Both/NA","To discover causal variant and assess phenotype variability.","MYO7A","c.1184G>A (p.R395H)","AR","Affymetrix 50K linkage, Sanger sequencing","All frequency","Bithermal caloric testing; clinical history.","NA"]
["https://doi.org/10.1016/j.heares.2011.08.010","Weegerink, N.J.D. et al (2011)","Netherlands","SNHL","Family-based study",60,"Both/(mean male: 3.3 years; mean female: 26.4 years)","To characterize severity, progression, and sex differences.","SMPX","c.214G>T (p.Glu72X)","XL","LinkageXp22, NGS of X genes","Males: early severe progressive, high-frequency first. Females: milder, variable, asymmetric.","Electronystagmography; rotatory and caloric vestibular tests.","NA"]
["https://doi.org/10.1002/ajmg.a.31486","Huculak, C., Rogala, L. and Rogaeva, E. (2006)","Canada; Chinese and Caucasian cohorts","SNHL","Case-control genetic study","40 Chinese, 40 Caucasian patients; 200 controls total.","NA","To determine if GJB2 V37I causes hearing loss.","GJB2 ","c.109G>A (p.Val37Ile)","AR","Sanger Sequencing","mild-moderate, high frequency","NA","NA"]
["https://doi.org/10.1016/j.heares.2014.12.006","Lenarduzzi, S. et al (2015)","Italy","Usher Syndrome","Validation and prospective cohort",47,"Both/NA","To identify causative alleles; improve diagnostic yield and counselling.","USH2A, MYO7A, CDH23, PCDH15, USH1C, PDZD7, GPR98, USH1G, WHRN, CLRN1.","WFS1: c.2389G>A (p.D797N), p.A716T, p.K836T,  p.K836N, p.E864K; MYO15A: c.5492G>T (p.Gly1831Val); GJB2: c.109G>A (p.Val37Ile; V37I); CDH23: p.P240L, p.R1588W, p.R2029W; SLC26A4: c.2168A>G (p.H723R)","AR","Sanger Sequencing","USH1: profound congenital; USH2: moderate–severe, sloping, congenital/early.","Spontaneous/evoked eye movements and bithermal caloric testing.","USH1: areflexia common; USH2: NA"]
["https://doi.org/10.3389/fgene.2021.780874","Moon, I.S. et al (2021)","United States of America","SNHL","Genetic and clinical cohort analysis",18,"Both/NA","To identify variants; assess phenotype and implantation results.","TMPRSS3","p.Thr70fs*19, p.Ala138Glu","AR","Sanger Sequencing","Prelingual, severe, progressive post lingual","NA","NA"]
["https://doi.org/10.1002/(sici)1098-1004(200004)15:4%3C388::aid-humu27%3E3.0.co;2-n","Adato, A. et al (2000)","Israel","Usher Syndrome","Mutation screening study","11 families","NA","To detect novel USH2A mutations and polymorphisms.","USH2A","239-242insCGTA, R334W, T1515M","AR","Exon screening of all 20 coding exons","Moderate to severe","NA","NA"]
["https://doi.org/10.1097/mao.0000000000003825","Achard, S. et al (2023)","France","SNHL","Single center observational study",64,"Both/15 years","To assess recurrent BPPV frequency and features","STRC","Biallelic STRC gene deletions","AR","MLPA or NGS CNV detection","Congenital, mild to moderate","Symptom criteria, physician confirmation, canalith maneuvers, limited VEMP.","Vertigo, BPPV"]
["https://doi.org/10.1038/ejhg.2013.5","Abdelfatah, N. et al (2013)","Canada","SNHL","Linkage study","6 famillies","Both/NA","To find culprit variant; evaluate phenocopies against carriers","KCNQ4","c.806_808delCCT (p.S269del)","AD","Sanger Sequencing","Carriers: bilateral sloping SNHL; non-carriers: variable configurations","NA","NA"]
["10.1016/j.jgg.2012.11.002","Zong, L. et al (2012)","China","SNHL","Haplotype study","1 family","NA","To exclude MYH14/CEACAM16; refine causal interval","YH14, CEACAM16, KCNA7, KCNJ14, KCNC3, KPTN, ERCC1, KCNN4","MYH14: c.657G>A (rs4801822), c.2127A>G (rs1651553)","AD","Genome wide linkage analysis","Post lingual, progressive, high to all frequencies ","Clinical assessment; HRCT temporal bone normal","NA"]
["https://doi.org/10.1097/aud.0000000000000878","Roman-Naranjo, P. et al (2020)","Spain","Meniere's Disease","Case-control study","46 families","Both/NA","To identify genes with excess rare variants in FMD","OTOG","p.V141M, p.V269I, p.R2802H","AD","Whole exome sequencing","Bilateral","Clinical MD criteria; serial audiograms; MRI to exclude other causes","Episodic vertigo"]
["https://doi.org/10.1007/s00405-016-3896-6","Acke, F.R. et al (2016)","Belgium","Stickler Syndrome","Cross-sectional audiometry",20,"Both/NA","To characterize onset, configuration, and progression of hearing loss","COL2A1, COL11A1","Truncating variants","AD","Prior molecular confirmation; no new sequencing performed","Type 1: mild high frequency, non-progressive","Clinical history; limited vestibular testing; DPOAE recorded","Rare vertigo, one compensated vestbiular hypofunction"]
["https://doi.org/10.1002/ajmg.a.35572","Babanejad, M. et al (2012)","Iran","SNHL","Homzygosity mapping ","144 families","NA","To identify linked loci and causal variants","MYO15A, SLC26A4, TMC1, TECTA, ILDR1, MARVELD2, PJVK, LRTOMT, OTOF, MYO7A",null,"AR","STR linkage; exon sequencing; segregation testing","Prelingual, nonprogressive, severe to profound","Tandem-gait, Romberg; ABR/TEOAE in subsets","NA"]
["10.1136/jmedgenet-2017-104721","Chattaraj, P. et al. (2017)","United States of America","Non-syndromic EVA","Genotype-haplotype mapping","NIH: 34 M2, 15 M1, 83 M0; Danish: 6 M1","NA","To define CEVA haplotype and assess association with EVA","SLC26A4","Exonic variants","AR","Targeted MPS","severe","CT/MRI EVA metrics; midpoint diameter criteria applied","EVA radiologic enlargement"]
["https://doi.org/10.1136/jmg.38.8.515","Laer, LV. et al. (2001)","Belgium, United Kingdom, United States of America","SNHL","SNP haplotype study","35 BE + 30 UK + 49 US patients; 150 controls","NA","To assess linkage disequilibrium supporting a common ancestor","GJB2","35delG","AR","SNP genotyping","congenital, all frequency, non-progressive","NA","NA"]
["https://doi.org/10.1007/s00439-021-02405-w","Solovyev, AV. et al. (2022)","Eurasia","Nonsyndromic hearing loss","SNP genotyping/meta-analysis study","23 homozygotes; 391 reference individuals; 16,177 literature cases","NA","To determine origin, age, and spread of c.-23+1G>A","GJB2","c.-23+1G>A (IVS1+1G>A)","AR","SNP genotyping","Congential","NA","NA"]
["https://doi.org/10.1007/s00438-014-0979-1","Sang, Q. et al. (2015)","China","SNHL","Mutation analysis study","1 family","NA","To detect causal variants in PTPRQ","PTPRQ","c.16_17insT (p.L8fs18); c.2714delA (p.E909fs922)","AR","Nimblegen capture; Illumina HiSeq; filtering, databases","Severe to profound, prelingual","NA","NA"]

{"sheet":"Supplementary Table S3.","index":3,"n_rows":18,"n_cols":14,"rows_kept":18}
["Supplementary Table S3. -  Summarized information of selected papers of mice (Mus musculus) subjects "]
[]
["DOI","Author/Year","Design","Sample Size","Sex/Median Age","Main Objective","Gene","Variant(s)","Inheritance Pattern","Sequencing or Genomic Analysis ","Hearing Profile","Methodology to Assess Vestibular Function","Vestibular Profile"]
["https://doi.org/10.1016/j.bpj.2021.09.029","Mansour, A. et al. (2021)","In vivo & ex vivo experimental mouse study using wild-type and mutant mice; biophysical measurements of tectorial membrane (TM) mechanics.","6 wild-type mice (12-14 weeks old); 2 juvenile mutant mice (4-6 weeks old); 5 adult mutant mice (12-14 weeks old). ","Sex not specified; Juvenile (4-6 weeks) v. adults (12-14 weeks)","To investigate how the loss of CEACAM16 affects tectorial membrane traveling wave properties (speed, decay constant) and material properties (shear modulus, viscosity), and to determine whether these changes align with progressive hearing loss.","CEACAM16","Loss of function mutation","na","na","• Juvenile mutant mice: near-normal cochlear function.\n• Adult mutant mice: elevated ABR thresholds, absent DPOAEs, reduced cochlear sensitivity (progressive hearing loss).","none reported","na"]
["https://doi.org/10.1186/s12915-022-01257-8","Lewis, MA. et al. (2022)","Large-scale mutagenesis screening in mouse knockout lines (observational + genetic mapping and confirmation)","1311 knockout lines screened (2218 wildtypes + 6798 mutants); 25 lines had non-segregating phenotypes, 8 lines fully characterized","Both sexes used where possible (paired littermate controls); males used for mapping crosses; ABR: 14 weeks\nBehavioural/vestibular: ~9 weeks\nAdditional ages tested for progression studies (P4 pups, adults at various timepoints)","To identify spontaneous mutations causing hearing loss or vestibular dysfunction arising during breeding in a large-scale targeted knockout programme.\nTo map, sequence, and functionally validate these spontaneous mutations.","Klhl18, Atp2b2, Tbx1","g.9:110455454C>A, p.(Val55Phe) (missense, homozygous recessive); g.6:113759212G>C, p.(Arg969Gly); 36.7 kb deletion including last 9 exons of Map3k5 + first exon of Map7; Single exonic SNV in 3 Mb region (homozygotes: complete deafness + vestibular defects)","Knockout model: Autosomal recessive; Semidominant Inheritance","Whole-exome sequencing (Agilent SureSelect Mouse All Exon kit, HiSeq 2000/4000)\nVariant calling with Samtools, Dindel, Pindel, BreakDancer\nFiltering using Ensembl VEP + Mouse Genomes Project database\nSanger sequencing for candidate confirmation\nSegregation analysis within colonies\nProtein modelling (Phyre2 + PyMOL)","Klhl18lowf: Low-frequency progressive hearing loss, no gross inner ear malformation\nAtp2b2Tkh: Progressive HL (high frequencies first), semi-dominant, no vestibular deficit\nMap3k5-Map7 deletion: Progressive HL (high frequency first), organ of Corti degeneration with age\nTbx1ttch: Complete deafness (no ABR up to 95 dB)","Behavioural observation for circling and head-bobbing; Contact righting reflex test (time to right when inverted in Petri dish); Histological analysis:\nMicroCT, immunohistochemistry, SEM to examine vestibular morphology\nInner ear dissection and clearing","Klhl18, Atp2b2, Map3k5/Map7 lines: Normal gait/balance (no vestibular defect reported)\nTbx1ttch: Severe vestibular malformations (absent or thin semicircular canals, collapsed saccule/utricle, disorganized utricular hair cells) + overt behavioural abnormalities (circling, head-bobbing)"]
["https://doi.org/10.1038/s41598-018-29709-8","Nakanishi, H. et al. (2018)","Preclinical experimental study using transgenic and knockout mice.\nCreated BAC transgenic lines (Tg[PTmc1::Tmc2]; positive and negative BAC controls also generated).\nMultimodal phenotyping: molecular assays (qRT-PCR), hair-cell morphology (SEM), hair-cell physiology (whole-cell mechanotransduction recordings), FM1-43 dye uptake assays, ABR, DPOAE, immunohistochemistry for ion channels and hair-cell markers, and endocochlear potential measurement.\nTime course analyses at early postnatal ages (P6–P7 electrophysiology) and juvenile ages (P12, P16, P19, P22, P25).",9,"Electrophysiology (whole-cell mechanotransduction currents): P6–P7.\nFM1-43 uptake: P12, P16, P25.\nABR thresholds: P16 (primary), then longitudinal at P19, P22, P25.\nSEM morphology: examples at P25 (and earlier P16 shown in supplement).\nEndocochlear potential and DPOAE measured at P16.","To test whether persistent expression of Tmc2 (under the Tmc1 promoter) in mature cochlear hair cells can restore auditory function in Tmc1-deficient mice and to characterize the extent and durability of any rescue.","Tmc1; Tmc2","targeted deletion Tmc1∆/∆ (loss of Tmc1), Tmc2∆/∆ (loss of Tmc2) for some experiments, and a BAC transgene Tg[PTmc1::Tmc2] (Tmc2 cDNA inserted under Tmc1 promoter; exons 8–9 of Tmc1 deleted in the BAC to prevent residual Tmc1 expression). Positive control: Tg[PTmc1::Tmc1]; negative control: Tg[Tmc1∆Ex8_9].","Dominant; semidominant inheritance","BAC recombineering to construct transgenes (Red/ET counter-selection).\nGenotyping: PCR assays specific for endogenous and transgenic alleles.\nqRT-PCR (TaqMan) to quantify endogenous and transgenic Tmc2 mRNA (transgenic and endogenous transcripts distinguished by transcript-specific primers/probes).\nNo whole-genome or exome sequencing was used here; protein localization and functional tests used instead.","Tmc1∆/∆: deaf (no ABR responses), hair-cell degeneration in both IHCs and OHCs.\nTg[PTmc1::Tmc2]; Tmc1∆/∆ (primary experimental group): partial, transient rescue:\nAt P16, ABR thresholds were ~80 dB SPL (significantly better than Tmc1∆/∆ which had no responses), but worse than wild-type.\nHearing thresholds progressively deteriorated with age; by P25 no ABR responses to 90 dB SPL were detected.\nFM1-43 uptake: present in IHCs and OHCs at P12 and P16; inner-HC uptake declined by P25 while OHC uptake remained detectable.\nMechanotransduction currents: inner HCs of Tg[PTmc1::Tmc2]; Tmc1∆/∆; Tmc2∆/∆ showed currents not significantly different from Tmc1+/∆;Tmc2∆/∆ (i.e., good inner-HC rescue early), but outer-HC currents were reduced compared to controls (partial rescue).\nDPOAEs: not restored in Tg[PTmc1::Tmc2]; Tmc1∆/∆ at P16 (indicating cochlear amplifier / OHC system-level function was not recovered).\nHair-cell morphology: stereocilia bundles better preserved in Tg[PTmc1::Tmc2];Tmc1∆/∆ at P25 versus degeneration in Tmc1∆/∆.","Behavioral vestibular testing: The paper does not emphasize longitudinal vestibular-behavioural phenotyping in the Tg[PTmc1::Tmc2] rescue experiment (the Tmc1∆/∆ single mutant is reported to have normal vestibular function, whereas Tmc1∆/∆;Tmc2∆/∆ double mutants are profoundly vestibularly deficient in prior work cited). The rescue paper’s primary vestibular readouts were physiological rather than behavioral.\nPhysiological vestibular assay used here: whole-cell mechanotransduction current recordings from vestibular type II hair cells (ex vivo). The paper reports that Tg[PTmc1::Tmc2]; Tmc1∆/∆ vestibular type II hair cells had robust sensory transduction currents that were significantly larger than those recorded from Tmc1+/∆;Tmc2∆/∆ controls (supplementary data).\n","transgenic Tmc2 expression preserved or enhanced vestibular hair-cell mechanotransduction currents — consistent with the known persistent expression and role of Tmc2 in vestibular HCs. No detailed vestibular behavioral deficits or recovery time courses are reported in the main figures for the Tg[PTmc1::Tmc2] line."]
["https://doi.org/10.1523/jneurosci.3635-11.2012","Goodyear, RJ. et al. (2012)","In vivo mouse model study using Ptprq knockout mice to assess single-gene functional knockout, comparison of homozygous mutants with heterozygous controls and morphological, electrophysiological and behavioural phenotyping","Functional null Ptprq; Heterozygous Ptprq; Ptprq WT controls. Vestibular evoked potential (VsEP) testing: Ptprq⁻/⁻ n=15; Ptprq⁺/⁻ n=15; Ptprq⁺/⁺ n=4. ","Both sexes used. Ages 2-4 months for function tests; P2-P380 for histology and morphometric analysis ","To examine vestibular hair bundle morphology and assess vestibular function in Ptprq null mice, investigating whether hair bundle defects explain the vestibular dysfunction observed in humans with PTPRQ mutations.","Ptprq ","Functional null allele","na","Genotyping of mice by PCR ","Ptprq⁻/⁻ mice previously reported to lose high-frequency auditory hair cells and are profoundly deaf\nThis study did not perform detailed audiometry but confirmed the auditory phenotype from prior work","Vestibular Evoked Potentials (VsEPs):\nLinear acceleration pulses delivered via head clip + voltage-controlled mechanical shaker\nSignal averaged electrophysiological recordings (300–3000 Hz filter, 100 kHz sampling)\nThresholds, amplitudes, and latencies measured for P1 response peak\nBehavioral Tests:\nReaching reflex (forelimb extension toward approaching surface)\nRotarod (motor coordination, latency to fall)\nSwimming test (circling, rolling, submersion scored)","VsEP Results:\n12/15 Ptprq⁻/⁻ mice showed absent VsEP responses\n3/15 showed responses only at very high stimulus levels → marked vestibular hypofunction\nHeterozygotes had normal VsEP thresholds\nBehavioral Findings:\n7/8 Ptprq⁻/⁻ mice showed subtle but distinct vestibular deficits (abnormal swimming posture, occasional circling)\nReaching reflex and rotarod performance mildly impaired\nMorphological Findings:\nHair bundle elongation (up to 50%) in extrastriolar utricle regions\nStereocilia loss and fusion in utricle, saccule, and cristae\nAbnormal hair bundle morphology persisted up to 12 months"]
["https://doi.org/10.1007/s10162-011-0270-7","Keller, JM. et al. (2011)","Selective breeding of outbred NIH Swiss mice to derive two lines (AFHL and HFHL) based on ABR thresholds; crosses to C3HeB/FeJ; backcrosses to generate N2 cohorts; quantitative trait locus (QTL) mapping; phenotypic assays (ABR, DPOAE, EP, histology)","AFHL-N2: n = 675 mice \nSpringerLink\n\n- HFHL-N2: n = 306 mice \nSpringerLink\n\nOther groups (founders, F-generations) also used; phenotypic measurements for many individuals (ABR etc.) across age.","Both males and females; 8 weeks old for N2 cohorts for ABR thresholds; also some measurements across ages such as 4, 26, 52 weeks for DPOAE","To identify genetic loci (QTLs) underlying variation in high-frequency hearing loss in NIH Swiss mice, particularly those that produce frequency-specific (basal cochlea) deficits (i.e. HFHL), and to characterize the phenotype (onset, progression, cochlear morphology, outer hair cell function).","Cdh23, Gipc3","Hfhl1, Hfhl2, Cdh23ahl, Gipc3ahl5","Complex genetics (QTLs)","Genome-wide SNP genotyping on N2 populations (hundreds of SNPs per line) \n\n\n- QTL mapping (marker regression, interval mapping, composite interval mapping) using ABR thresholds and backcrossed populations \n\n\n- Sequencing of candidate gene regions (Cdh23, Gipc3) in NIH Swiss, AFHL, HFHL, and C3HeB/FeJ to detect the known “ahl” and “ahl5” mutations.","AFHL line: severe early-onset sensorineural hearing loss across all frequencies tested; elevated ABR thresholds for click, 8, 16, 32 kHz. DPOAEs essentially absent by 4 weeks. Histological degeneration (hair cell loss, spiral ganglion degeneration) across cochlea at older ages (52 weeks). \n\n\n- HFHL line: frequency-specific loss (high frequencies, especially 32 kHz), milder onset; DPOAEs relatively normal below ≈30 kHz even up to older ages, but reduced / absent at high frequencies; some progression over age; cochlear histology shows degeneration limited to basal (high-frequency) region with age.","na","na"]
["https://doi.org/10.3389/fnins.2019.01255","Calabro, KR. et al. (2019)","Traditional knockout (KO) mouse model study. Creation and phenotypic characterization of a novel Myo7a−/− mouse line with complete MYO7A deficiency.","Western blot: n = 3 eyes (per genotype), n = 2–4 cochleae (per genotype)\nABR hearing tests: n = 5–6 mice/genotype (both sexes), age = 5 months\nOCT / ERG: n = 10–11 mice/genotype (equal males and females), age = 5 months\nHistology / microscopy: n = 4 mice/genotype per time point","Mice of both sexes were included in all experiments. Median age at auditory testing: 5 months.","To generate a new, easily genotyped Myo7a−/− mouse model and fully characterize its auditory, vestibular, and retinal phenotypes, including assessing whether partial MYO7A loss (Myo7a+/−) affects auditory function.","Myo7a","Deletion of exons 10–11 (motor + actin-binding domains) via Cre-lox recombination on a C57BL/6J background.","AR","PCR-based genotyping (WT and KO allele amplification)\nConfirmation of rd8/Crb1 allele removal by screening\nWestern blot to confirm MYO7A absence","Myo7a−/−: Profound bilateral sensorineural hearing loss across all frequencies (8, 16, 32 kHz). Near-complete loss of inner and outer cochlear hair cells.\nMyo7a+/−: Significant reduction in hair cell numbers and elevated ABR thresholds at mid- and high-frequencies (first report showing haploinsufficiency affects hearing).\nMyo7a+/+: Normal hearing.","Structural assessment of vestibular hair cells (saccule, utricle, semicircular canal ampullae) via dissection, hematoxylin staining, and light microscopy of surface preparations. Behavioral observation (spinning, hyperactivity, head-tilt) noted in KO mice.","Myo7a−/−: Behavioral vestibular dysfunction (spinning, head tilt) present, but no gross structural loss of vestibular hair cells detected.\nMyo7a+/− and +/+: Normal vestibular behavior and vestibular hair cell morphology."]
["https://doi.org/10.1016/j.ajhg.2010.01.016","Odeh, H. et al. (2010)","Generation and analysis of multiple Grxcr1 mutant alleles (spontaneous mutations and transgene insertions).\nPhenotypic characterization via auditory, vestibular, molecular, and histological assays.\nLocalization studies using in situ hybridization and immunohistochemistry.",">500 F2 offspring used for mapping cross.","Both male and female mice used","To identify the gene responsible for the pirouette phenotype, characterize its mutation spectrum, determine expression/localization, and link loss of function to cochlear and vestibular pathology.","Grxcr1","pi: Large genomic inversion disrupting Grxcr1\npi2J (nm2766): ~200 kb deletion removing exon 1 and most of intron 1\npi3J (nm3325): Similar deletion affecting exon 1\npitg370: Transgene insertion disrupting intron 1\npitde: Transgene insertion disrupting intron 2","AR","Linkage mapping (SSLP markers on chromosome 5).\nSouthern blotting & long-range PCR to define breakpoints.\nSanger sequencing to confirm deletions, inversions, and insertion sites.\nRT-PCR to analyze transcript integrity.\nSequence alignment to confirm evolutionary conservation of GRXCR1.","Profound congenital deafness: No auditory brainstem response (ABR) at any frequency tested.\nCochlear histology: Stereocilia disorganized and fragmented, progressive hair-cell degeneration.","Behavioral observation: Head bobbing, circling, hyperactivity, and poor swimming used as indicators.\nHistological analysis: Scanning electron microscopy of vestibular stereocilia bundles.","Severe bilateral vestibular dysfunction: Head tossing, circling, ataxic gait, inability to swim properly.\nMorphological findings: Disorganized stereocilia bundles in vestibular hair cells."]
["https://doi.org/10.1007/s00335-004-2344-x","Rhodes, CR. et al. (2004)","Phenotype-driven ENU mutagenesis screen in mice","282 (71 mutants); SEM & paint-filling: multiple time points, n per group typically 3–15\nAuditory physiology: P20–23 +/+ n=6, Hdb/+ n=11, Hdb/Hdb n=2","Both sexes used, ages from embryonic day E16.5 through 5 months\nMedian age focus for hearing assessment: P20–23","To characterize a novel ENU-induced headbanger (Hdb) mouse line with abnormal vestibular behavior and hearing loss, identify the causal mutation, and assess its impact on cochlear and vestibular hair cell morphology and function.","Myo7a","A531T","AD","Genome-wide microsatellite scan (59 markers) → fine mapping to Chr 7 (1.5 cM region)\nDirect sequencing of candidate genes (Pak1, Wnt11, Myo7a)\ncDNA analysis from testes RNA\nGenotyping: PCR amplification with engineered XcmI restriction site for allelic discrimination\nComplementation test with shaker-1 (Myo7a^4626SB^) mutants.","Heterozygotes (Hdb/+): Elevated CAP thresholds up to +40 dB at 3–12 kHz (low frequencies); normal high-frequency thresholds\nHomozygotes (Hdb/Hdb): Elevated CAP thresholds across all frequencies\nEndocochlear potential: Normal (~98.5 mV in all genotypes)","Behavioral screening – head bobbing, circling, hyperactivity\nPaint-filling technique – inner ear endolymphatic space visualization (semicircular canals, utricle, saccule)\nScanning Electron Microscopy (SEM) – utricular stereocilia morphology (P20 and 5 months)","No gross anatomical defects in semicircular canals, utricle, saccule\nSEM findings: Utricular stereocilia long, thin, wispy, lacking normal staircase arrangement, become splayed at 5 months\nNo stereocilia fusion (unlike cochlea)"]
["https://doi.org/10.1002/jnr.24905","Zhao, T. et al. (2021)","Animal experimental study – creation and phenotyping of two novel Cdh23 mutant mouse models (Cdh23V2J2/V2J2 and Cdh23erl2/erl2) using CRISPR/Cas9 genome editing.",null,"Both male and female mice used.\nAge range: 3 weeks to 12 months (hearing profile measured longitudinally).","To generate and characterize two novel Cdh23 mutant mouse models on the CBA/CaJ background to investigate the effects of Cdh23 mutations on hearing and vestibular function, and to establish models for human nonsyndromic and syndromic hearing loss.","Cdh23 ","Cdh23V2J2/V2J2: c.235delG (frameshift mutation in exon 5 → premature stop codon → loss-of-function/null allele)\nCdh23erl2/erl2: c.208T>C (missense mutation in exon 5) introducing BstN1 site","AR","CRISPR/Cas9-based genome editing\nPCR genotyping with Sanger sequencing\nBstN1 digestion for genotyping erl2 allele\nOff-target analysis using CRISPR design tool (no off-target effects detected)","Cdh23V2J2/V2J2: Congenital profound deafness (no ABR response at 3 weeks at 100 dB SPL)\nCdh23erl2/erl2: Progressive sensorineural hearing loss (ABR thresholds elevated starting ~3 months; progressive until 12 months)","Behavioral circling test: Quantified head rotations in a box using DeepLabCut and TensorFlow tracking.\nForced swimming test: Scored swimming ability (0–3 scale; 3 = severe vestibular dysfunction with continuous underwater tumbling).","Cdh23V2J2/V2J2: Severe vestibular dysfunction (circling behavior, unbalanced swimming, underwater tumbling).\nCdh23erl2/erl2: No obvious vestibular dysfunction (normal swimming, no circling behavior)."]
["https://doi.org/10.1038/nn1828","Russel, IJ. et al. (2007)","Experimental genetic mouse study using a knockout model (Tectb–/–). Electrophysiological, mechanical, and morphological analyses were performed.","Varies by experiment:\n- CAP and DPOAE recordings: n = 10 per genotype\n- Extracellular OHC potentials: n = 10 per genotype\n- Basilar membrane mechanics: n = 4 per genotype\n- Light microscopy: Tectb–/– n = 9, Tectb+/– n = 8, Tectb+/+ n = 7\n- SEM: Tectb–/– n = 5, Tectb+/– n = 2, Tectb+/+ n = 2","Mixed sex; age mostly <3–4 months to avoid age-related hearing loss; specific ages: P2–P158 depending on experiment.","To determine the role of Tectb in cochlear function, particularly in low-frequency hearing, and to understand how its absence affects tectorial membrane structure, outer hair cell (OHC) function, and cochlear frequency tuning.","Tectb","Functionally null mutation (Tectb–/– knockout).","Experimental homozygous knockout; recessive in experimental context.","Gene targeting in embryonic stem (ES) cells; PCR confirmed absence of Tectb transcript; immunoblotting for β-tectorin protein.","Low-frequency hearing loss (<20 kHz) shown by CAP thresholds and DPOAEs\nHigh-frequency sensitivity (>20 kHz) largely preserved, with sharper tuning curves\nDPOAEs reduced in low-frequency range, normal in high-frequency range\n CAP tuning curves show enhanced frequency selectivity and steeper slopes at low and high frequencies.","No vestibular function assessment reported in this study.","na"]
["https://doi.org/10.1016/j.heares.2011.08.005","Hurd, EA. et al. (2011)","In vivo mouse model study; heterozygous Chd7 (Chd7^Gt/+) mice compared to wild type littermates. Assessment included ABR, DPOAE, cochlear histology, scanning electron microscopy (SEM), immunofluorescence, and noise exposure.","ABR/DPOAE: Chd7^Gt/+ (N=17), wild type (N=13), 5-week-old, sex-matched.\nNoise exposure: Chd7^Gt/+ (N=17), wild type (N=12), adult.\nSEM / histology: 6-week-old sex-matched mice.",null,"To characterize expression of Chd7 in mature inner and middle ear, assess cochlear and middle ear morphology, determine auditory thresholds and DPOAE, and evaluate susceptibility or resistance to noise exposure in Chd7^Gt/+ mice.","CHD7","heterozygous Chd7^Gt/+ mutation","heterozygous, mimicking AD haploinsufficiency in human","Genotyping for Chd7^Gt/+ and for Cdh23^ahl allele (noise/high-frequency susceptibility)","Mild low- to mid-frequency hearing loss in Chd7^Gt/+ mice (ABR thresholds elevated at 4 and 16 kHz; not at 32 kHz).\nFlattened or absent DPOAEs at 8, 16, and 24 kHz, indicating a combination of conductive and sensorineural hearing loss.\nABR threshold shifts after noise exposure were smaller in Chd7^Gt/+ mice with stapedial fixation compared to wild type.","Not specifically assessed in this study","na"]
["10.1016/j.heares.2010.11.002","Jones et al., (2010)","DFNA9 – Autosomal dominant, late-onset, progressive, nonsyndromic hearing loss with vestibular dysfunction","Coch−/− (n=11 at 13 months; n=10 at 21 months)\n\nCoch+/− (n=12 at 13 months; n=7 at 21 months)\n\nCoch+/+ (n=9 at 13 months; n=8 at 21 months)\n\nVsEP testing: Coch−/− (n=5–10), Coch+/− (n=5–7), Coch+/+ (n=5–8)\n\nCochG88E/G88E (n=7 at 5 months; n=12 at 7 months; n=8 at 21 months)","Ages tested: 5, 7, 13, 13.5, and 21 months","To compare hearing and vestibular deficits in two mouse models (Coch−/− null and CochG88E/G88E knock-in) and correlate findings with human DFNA9, providing insights into pathology and inheritance mechanisms","COCH (coagulation factor C homology, cochlin)","Knock-out (Coch−/−)","Autosomal Dominant","Not sequencing-focused; functional analysis used:\n\nAuditory Brainstem Response (ABR)\n\nVestibular Evoked Potential (VsEP)\n\nHistological evaluation","Coch−/−: High-frequency loss at 21 months (9/11 with absent ABR at 41.2 kHz). CochG88E/G88E: Elevated thresholds at all frequencies by 21 months, more severe than Coch−/−\n\nProgressive, late-onset","NA","Coch−/−: Elevated VsEP thresholds at 13 and 21 months\n\nCochG88E/G88E: Dysfunction detectable as early as 7 months\n\nVestibular deficits precede hearing loss"]
["10.1016/j.neuroscience.2009.08.043","Minekawa et al./2009","Gjb2-based deafness (model of dominant-negative inheritance)","In vivo and in vitro functional studies on a transgenic mouse model","Gjb2 R75W transgenic mice and controls","Evaluate developmental changes in OHC function and structure in a Gjb2 dominant-negative mouse model.","GJB2 (human Cx26 with R75W mutation)","R75W","Dominant Negative","DPOAE, histology, immunohistochemistry, electrophysiology (patch-clamp)","NA","NA","NA"]
["10.1093/hmg/ddn311","Mansour et al./2009","Muenke syndrome","Cohort study and mouse model functional analysis","37 human subjects, Fgfr3P244R mice","Not specified","Evaluate hearing in a large cohort of Muenke syndrome subjects and in the corresponding mouse model.","FGFR3","P250R (human), P244R (mouse)","AD","Audiometry, ABR, histology","Incompletely penetrant, predominantly low-frequency sensorineural hearing loss","NA","NA"]
["10.1093/hmg/ddn236","Robertson et al./2008","Late-onset hearing loss and vestibular dysfunction (DFNA9)","Knock-in mouse model study","CochG88E/G88E mice and controls","Not specified","Study DFNA9 pathogenesis and cochlin function using a mouse model with the human G88E mutation.","COCH","G88E","AD","Gene targeting, RT-PCR, immunohistochemistry, VsEP, ABR, DPOAE","Substantial hearing loss at 21 months, progressing to profound","Vestibular function assessed by vestibular-evoked potentials (VsEPs) in Coch G88E knock-in mice.","Vestibular dysfunction beginning as early as 11 months, increasing with age"]

{"sheet":"Supplementary Table S4.","index":4,"n_rows":9,"n_cols":14,"rows_kept":9}
["Supplementary Table S4.   Summarized information of selected papers of human participants and mice (Mus musculus) subjects "]
[]
["DOI","Author/Year","Disease","Design","Sample Size","Sex/Median Age of Onset","Main Objective","Gene","Variant(s)","Inheritance Pattern","Sequencing or Genomic Analysis ","Hearing Profile","Methodology to Assess Vestibular Function","Vestibular Profile"]
["https://doi.org/10.1007/s00439-018-1901-4","Bademci, G. et al. (2018)","Autosomal recessive nonsyndromic moderate sensorineural hearing loss (SNHL)","Genetic association and functional study using human families (three unrelated multiplex consanguineous families) + expression studies in mouse inner ear (RT-PCR and immunofluorescence)","3 unrelated multiplex families (8 affected individuals clinically evaluated); 704 unrelated Turkish probands screened for variant frequency","Not fully specified for all participants; proband II:3 from family 3 was 5 y.o.; sex distribution not systematically reported","To identify the genetic basis of autosomal recessive nonsyndromic moderate SNHL in consanguineous families and characterize MPZL2 as a novel hearing loss gene","MPZL2","NM_005797.3:c.72delA (p.I24Mfs*22) — frameshift variant in exon 2 causing truncation of protein","AR","Whole Exome Sequencing (WES) for all probands (Illumina platforms)\n- Whole Genome Sequencing (WGS) in proband of Family 1 (BGISEQ-500)\n- Variant filtering using gnomAD, EVS, dbSNP, internal databases\n- CNV detection: CNVnator\n- SV detection: BreakDancer\n- Co-segregation confirmed by Sanger sequencing\n- Haplotype analysis indicating founder effect","Bilateral, symmetric, prelingual moderate SNHL (pure-tone average 41–70 dB HL, 0.5–4 kHz). One individual had asymmetrical HL (moderate right ear, profound left ear). No evidence of progression (serial audiograms not available).","Clinical neurological examination: tandem walking, Romberg test. Parents reported no vertigo, dizziness, or balance problems.","Normal: no history of balance issues, normal Romberg, normal tandem gait; no vestibular dysfunction identified."]
["https://doi.org/10.1007/s12035-021-02422-w","Fu, X. et al. (2021)","Low-frequency sensorineural hearing loss (SNHL) in mice (Klc2-null) and a matching low-frequency hearing impairment in a human patient. ","Experimental Design (Screening analysis, audiometric and morphological analysis of mouse cochlea)",{"v":1752,"d":"1,752"},"Male: 14","To determine whether KLC2 (kinesin light chain 2), a motor protein component important for intracellular transport, is essential for cochlear (hair cell) function and hearing; to characterize what happens when Klc2 is deficient, both in mice and in a human, and to test if rescue via gene therapy is possible","Klc2","In human: c.1444-8_1444-6delTCC (NM_001134775.1) – an indel variant in KLC2 found by WGS in a 21-year-old male with low-frequency hearing impairment; In mice: complete knockout / null via CRISPR/Cas9 deleting coding region between intron 2 and intron 11 (so it abolishes the gene) using two sgRNAs.","Autosomal recessive ","Whole-genome sequencing (WGS) in the human subject to identify the KLC2 variant; CRISPR/Cas9 generation of knockout mice; genotyping PCR; verification of absence of off-target effects; RNA-seq (transcriptome) in mice (WT vs Klc2-KO) to see differential gene expression; qPCR, western blot for KLC2 expression across tissues, at different mouse ages; Co-immunoprecipitation followed by mass spec to identify interacting proteins / cargos.","Mice: Klc2-null C57BL/6J mice show elevated ABR (auditory brainstem response) thresholds at low frequencies (e.g. 4-12 kHz) by ~P40; high-frequency hearing relatively spared initially. Then progressive loss of outer hair cells (OHCs), especially in apical cochlear turn (which encodes low frequencies), with near-complete deafness by 8 months.; Human: bilateral hearing impairment, onset around 14 years; pure-tone audiogram showing low-frequency loss; abnormal speech recognition scores (SRS) and ABR waves absent or poor differentiation; distortion product otoacoustic emissions (DPOAEs) preserved (implying OHC function somewhat intact initially) in some frequencies","NA","NA"]
["https://doi.org/10.1016/j.ajhg.2018.05.011","Wesdorp, M. et al. (2018)","Autosomal recessive non-syndromic hearing impairment (NSHI)","Observational genetic study in humans (family-based homozygosity mapping, WES), supplemented with functional validation in Mpzl2-mutant mice","Humans: 3 families (Dutch and Turkish origin, total 8 affected individuals reported in detailed audiometric evaluation). Cohorts screened: 120 phenotype-based, 270 WES cohort. Mice: n=5 per genotype per age group (4, 8, 12 weeks)","Humans: both sexes, age of onset 3–9 years (mean 4 years). Mice: both sexes, ages 4–12 weeks tested.","To identify novel genetic causes of recessive NSHI and validate the functional role of MPZL2 in hearing","MPZL2","Homozygous c.72del (p.Ile24Metfs22), compound heterozygous c.72del / c.220C>T (p.Gln74) in affected humans; other rare truncating variants identified in Turkish families","Autosomal recessive ","Homozygosity mapping, VNTR marker analysis, whole-exome sequencing (Illumina HiSeq), Sanger sequencing for validation, CNV analysis by depth-of-coverage (CONIFER), qPCR for intragenic deletions","In mice: Early-onset, progressive sensorineural HI; thresholds elevated for click and tone-burst stimuli; high-frequency hearing affected first; histology showed degeneration of hair cells, supporting cells, organ of Corti, and mild spiral ganglion neuron loss (most pronounced at cochlear base) In humans: Symmetric, mild-to-moderate sensorineural HI; onset in early childhood (3–9 years); downsloping audiogram; progressive HI in adults; high-frequency hearing more severely affected; speech perception relatively preserved; ABR normal; OAEs partially preserved in mild cases; no vestibular involvement; no syndromic features","Electronystagmography (ENG) with rotary chair stimulation and caloric testing; cervical vestibular-evoked myogenic potentials (cVEMP); video head impulse tests (vHIT)","na"]
["https://doi.org/10.1111/cge.12915","Neuhaus, C. et al. (2016)","Autosomal dominant non-syndromic hearing loss (ADNSHL)","Observational study of two unrelated families with heterozygous truncating DIAPH1 mutations. Included clinical, audiological, genetic, and histological analyses.","Family 1: 5 affected individuals (I:2, II:2, II:3, III:1, III:2)\nFamily 2: 3 affected individuals (I:2, II:2, III:1; platelet counts unavailable for some)","Mixed; ages ranged from infancy (3 months) to elderly (64 years).","Extend clinical and molecular characterization of DFNA1, including hearing phenotype, platelet counts, and DIAPH1 expression in cochlear structures.","DIAPH1","Family 1: c.3624_3625delAG (p.Ala1210Serfs*31) – frameshift, exon 27\nFamily 2: c.3637C>T (p.Arg1213*) – nonsense, exon 27","AD","Family 1: Next-Generation Sequencing (NGS) panel of 66 deafness genes (MiSeq, Illumina); confirmed by Sanger sequencing; identified DIAPH1 c.3624_3625delAG (p.Ala1210Serfs*31); Family 2: Targeted Sanger sequencing of DIAPH1 exon 27 (after MYH9 ruled out); identified DIAPH1 c.3637C>T (p.Arg1213)*","Family 1: Congenital, progressive bilateral sensorineural hearing loss; initially mild–moderate in infancy, progressing to severe–profound; low, mid, and high frequencies affected; TEOAE and DPOAE absent; ABR thresholds elevated; Familiy 2: Bilateral, progressive sensorineural hearing loss; moderate in early childhood, progressing with age; PTA shows greater mid/high-frequency loss; TEOAE absent; ABR thresholds elevated","Clinical history and examination; no specific vestibular tests reported","na"]
["https://doi.org/10.1007/s00438-014-0979-1","Sang, Q. et al. (2015)","Autosomal recessive non-syndromic hearing impairment (DFNB84)","A family-based genetic study using whole-exome sequencing (WES) on affected individuals, followed by Sanger sequencing for co-segregation analysis in the family and screening in healthy controls","One Kazakh family with four affected and five unaffected members (four affected siblings, three unaffected siblings, and two unaffected parents).  along with 200 healthy unrelated Kazakh control individuals","Both ","To identify novel mutations in PTPRQ responsible for DFNB84 and to characterize the genetic and molecular characteristics of a Kazakh family with autosomal recessive non-syndromic hearing impairment","PTPRQ","Two novel biallelic (compound heterozygous) PTPRQ mutations: c.16_17insT (p.L8fsX18) and c.2714delA (p.E909fsX922)","Autosomal recessive. The affected members inherited both mutations, making them compound heterozygous, while unaffected members did not carry both together","Whole-exome sequencing (WES) was performed on three affected family members (II:1, II:4, and II:7) using the Nimblegen SeqCap EZ Library and sequenced on an Illumina Hiseq 2000 platform. Sanger sequencing was used for prescreening common deafness genes and for validating the identified PTPRQ mutations and co-segregation within the family, as well as in control individuals","Prelingual and bilateral sensorineural hearing impairment. Two affected members showed congenital deafness with no response to audiometry, while the other two affected members had severe deafness","Clinical history, physical examination, otoscopy; no formal vestibular tests in humans reported","The paper mentions that Ptprq knockout mice showed \"loss of function in the vestibular system,\" with absent vestibular-evoked potentials and subtle defects in swimming behaviour. However, no specific vestibular functional tests or findings were reported for the human participants in the family"]
["https://doi.org/10.1038/70516","McGuirt, WT. et al. (1999)","Autosomal dominant non-syndromic sensorineural hearing loss (DFNA13); mid-frequency “cookie-bite” pattern; non-progressive; mild or absent vestibular abnormalities in so","Human genetic linkage and mutation study; functional analysis in Col11a2 transgenic mice; histological and in situ hybridization studies","American family: 48 individuals; Dutch family: 49 individuals","Both/NA","Identify the causative gene for DFNA13 hearing loss and characterize its functional and structural effects in the inner ear","COL11A2","American family: c.1647C>T → p.Arg549Cys (exon 42)\nDutch family: c.970G>A → p.Gly323Glu (exon 31)","AD","SSCP (single-strand conformation polymorphism) screening; bi-directional Sanger sequencing; PCR-based genotyping; restriction digest confirmation; linkage analysis; YAC/PAC contig construction","Prelingual, non-progressive sensorineural hearing loss; predominantly mid-frequency (“cookie-bite”) pattern; audiograms from both families showed mid-frequency dips","Caloric testing in 8/17 affected individuals from Dutch family; some showed areflexia, but vestibular dysfunction largely asymptomatic","Weak or absent caloric responses in subset of Dutch family; otherwise normal vestibular function"]

{"sheet":"Supplementary Table S5.","index":5,"n_rows":436,"n_cols":17,"rows_kept":436,"merged":[[0,11,0,16]]}
["Supplemetary Table S5. - Risk of Bias Assessment for the selected Human Studies ",{"$nulls":10},"ROBINS-E Domains "]
[{"$nulls":11},"D1","Confounding-induced bias","D3","Bias in participant selection for the study","D6","Bias in outcome measurement"]
["DOI","Authors","Study Design","D1","D2","D3","D4","D5","D6","D7",null,"D2","Bias in exposure measurement","D5","Bias due to missing data","D7","Bias in the selection of reported results"]
["https://doi.org/10.1038/s41598-025-08801-w","Bae, SH. et al. (2025)","Retrospective Cohort "]
["https://doi.org/10.1177/00034894251315550","González-Aguado, R. et al. (2025)","Observational, prospective and descriptive study"]
["https://doi.org/10.1016/j.otoeng.2025.512217","González-Aguado, R. et al. (2025)","Cohort study"]
["https://doi.org/10.1007/s00405-025-09288-x","González-Aguado, R. et al. (2025)","Prospective observational study"]
["https://doi.org/10.1007/s00439-025-02730-4","Serey-Gaut, M. et al. (2025)","Retrospective Cohort "]
["https://doi.org/10.1002/mgg3.70075","Gong, GQ. et al. (2025)","Case series "]
["https://doi.org/10.1002/ohn.1074","Alonso, AV. et al. (2025)","Observational study"]
["https://doi.org/10.3390/ijms26041583","Nagy, N. et al. (2025)","Case report",null," "]
["https://doi.org/10.3390/genes15121592","Grzybowska-Adamowicz, J. et al. (2024)","Retrospective Cohort ",null," "," ",null," "," "," "]
["https://doi.org/10.1089/gtmb.2023.0550","Bouhouche, A. et al (2024)","Case report"," ",null," ",null," "," "]
["https://doi.org/10.5152/iao.2024.231252","Markova, TG. et al. (2024)","Case series "," ",null," ",null,null," "]
["https://doi.org/10.1038/s41598-024-55435-5","Lei, P. et al. (2024)","Familial-based Case series"," ",null," ",null,null," "]
["https://doi.org/10.1016/j.ijporl.2023.111484","Guo, L. et al. (2023)","Observational study"," ",null," ",null," "," "," "]
["https://doi.org/10.3390/genes14020457","Velde, HM. et al. (2023)","Familial-based Case series"," ",null," ",null," "," "," "]
["https://doi.org/10.1155/2022/5068869","Ma, J. et al. (2022)"," Familial-based Case series"," ",null," ",null,null," "," "]
["https://doi.org/10.1186/s12920-022-01289-7","Du, Q. et al. (2022)"," Familial-based Case series"," ",null," ",null,null," "," "]
["https://doi.org/10.1186/s13023-022-02244-6","Rad, A. et al. (2022)"," Familial-based Case series"," ",null," ",null,null," "," "]
["https://doi.org/10.1038/s41598-020-63256-5","Morín, M. et al. (2020)"," Familial-based Case series"," "," "," ",null," "," "," "]
["https://doi.org/10.3390/genes10100744","Yasukawa, R. et al. (2019)","Cross-sectional genetic epidemiology"," ",null," ",null," "," "," "]
["https://doi.org/10.3390/genes10121031","Noman, M. et al. (2019)"," Familial-based Case series"," ",null," ",null,null," "]
["https://doi.org/10.1038/s41431-023-01358-0","Singh, S. et al. (2023)","Longitudinal Cohort"," ",null," ",null,null," "]
["https://doi.org/10.1038/s41431-021-00891-0","Bueno, AS. et al. (2021)","Cross-sectional "," ",null," ",null,null," "]
["https://doi.org/10.1111/aos.14302","Wang, D. et al. (2019)","Case series "," ",null," ",null," "," "]
["https://doi.org/10.1002/mgg3.70080","Mohseni, M. et al. (2025)","Cross-sectional genetic epidemiology"," ",null," ",null," "," "]
["https://doi.org/10.1007/s00467-024-06507-1","Yadav, M. et al. (2024)","Retrospective Cohort ",null,null," ",null,null," "]
["https://doi.org/10.3390/genes16020123","Maekawa, K. et al. (2025)","Retrospective Cohort "," ",null," ",null,null," "]
["https://doi.org/10.3390/genes16010092","Maekawa, K. et al. (2025)","Cross-sectional genetic epidemiology"," ",null," ",null,null," "]
["https://doi.org/10.1016/j.ijporl.2024.112082","Morales-Angulo, C. et al. (2024)","Retrospective Cohort "," ",null," ",null,null," "]
["https://doi.org/10.1371/journal.pone.0309439","Teryutin, FM. et al. (2024)","Cross-sectional "," ",null," ",null,null," "," "]
["https://doi.org/10.3390/genes15091227","Gombojav, B. et al. (2024)","Cross-sectional genetic epidemiology"," ",null," ",null," "," "," "]
["https://doi.org/10.1038/s41598-024-70795-8","Choi, WH. et al. (2024)","Experimental Functional Analysis",null," "," ",null,null," "]
["https://doi.org/10.1007/s11033-024-09740-x","Idyahia, A. et al. (2024)","Case series "," "," "," ",null,null," "]
["https://doi.org/10.1186/s12886-024-03578-4","Serra, R. et al. (2024)","Cross-sectional "," ",null," ",null,null," "," "]
["https://doi.org/10.1038/s41598-024-61442-3","Tsukada, K. et al. (2024)","Observational comparative "," "," "," ",null,null," "," "]
["https://doi.org/10.3390/genes15040489","Sakuma, N. et al. (2024)","Cross-sectional genetic epidemiology"," "," "," ",null,null," "," "]
["https://doi.org/10.1038/s41598-024-57415-1","Watanabe, K. et al. (2024)","Cross-sectional ",null," "," ",null,null," "," "]
["https://doi.org/10.1186/s12920-023-01786-3","Zhang, L. et al. (2024)","Retrospective Cross-sectional "," "," "," ",null,null," "," "]
["https://doi.org/10.3390/genes12101569","Tesolin, P. et al. (2021)","Case series "," "," "," ",null,null," "," "]
["https://doi.org/10.1016/j.jmoldx.2021.07.007","Lin, Y-H. et al. (2021)","Cross-sectional "," ",null," ",null,null," "," "]
["https://doi.org/10.1016/j.heares.2021.108329","Roman-Naranjo, P. et al. (2021)","Case series "," ",null," ",null,null," "]
["https://doi.org/10.3390/genes12060820","Petrova, NV. et al. (2021)","Cross-sectional genetic epidemiology"," ",null," ",null," "," "," "]
["https://doi.org/10.1002/mgg3.917","Khan, A. et al. (2019)","Cross-sectional genetic epidemiology",null,null," ",null," "," "," "]
["https://doi.org/10.3390/genes10100772","Wu, C-C. et al. (2019)","Cross-sectional genetic epidemiology"," ",null," ",null," "," "," "]
["https://doi.org/10.3390/genes11030273","Oka, SI. et al. (2020)","Cross-sectional genetic epidemiology"," ",null," ",null," "," "]
["https://doi.org/10.1038/s41598-020-60259-0","Shinagawa, J. et al. (2020)","Observational, cross-sectional "," ",null," ",null," "," "]
["https://doi.org/10.1002/mgg3.1367","Guan, J. et al. (2020)","Cross-sectional "," ",null," ",null,null," "]
["https://doi.org/10.1016/j.ijporl.2020.110143","Liu, Xiao-Wen et al. (2020)","Cross-sectional "," ",null," ",null,null," "]
["https://doi.org/10.1038/s10038-020-0783-1","Cesca, F. et al. (2020)","Cross-sectional genetic epidemiology"," ",null," ",null,null," "]
["https://doi.org/10.1016/j.ijporl.2020.110247","Markova, TG. et al. (2020)","Cross-sectional "," ",null," ",null,null," "]
["https://doi.org/10.1186/s12881-020-01153-4","Singh, K. et al. (2020)","Cross-sectional "," ",null," ",null," "," "," "]
["https://doi.org/10.1007/s00405-020-06050-3","Liu, Y. et al. (2020)","Cross-sectional "," ",null," ",null," "," "," "]
["https://doi.org/10.1007/s11033-020-06016-y","Noman, M. et al. (2020)","Case series "," ",null," ",null," "," "," "]
["https://doi.org/10.1007/s11033-020-06037-7","Park, HR. et al. (202)","Case series "," ",null," ",null," "," "," "]
["https://doi.org/10.3390/genes12020274","Kabahuma, RI. et al. (2021)","Case series "," ",null," ",null,null," "]
["https://doi.org/10.1002/mgg3.1634","Xiao, C. et al. (2021)","Case series "," "," "," ",null,null," "]
["https://doi.org/10.1016/j.heares.2021.108227","Na, G. et al. (2021)","Case series "," "," "," ",null,null," "]
["https://doi.org/10.3390/genes12050684","Brozkova, D. et al. (2021)","Case series "," ",null," ",null,null," "]
["https://doi.org/10.1038/s41431-020-00790-w","Hirsch, Y. et al. (2021)","Case series "," ",null," ",null,null," "]
["https://doi.org/10.3892/etm.2021.10044","Neagu, A. et al. (2021)","Case series ",null,null," ",null,null," "]
["https://doi.org/10.1007/s11596-021-2422-2","Gao, Y. et al. (2021)","Case series ",null,null," ",null,null," "]
["https://doi.org/10.20344/amp.13781","Reis, CS. et al. (2021)","Cross-sectional ",null," "," ",null,null," "," "]
["https://doi.org/10.3390/genes12101578","Choi, Soon-II. et al. (2021)","Cross-sectional genetic epidemiology",null,null," ",null,null," "," "]
["https://doi.org/10.1097/aud.0000000000001099","Sebastien P F JanssensdeVarebeke et al. 2021","Cross-sectional genetic epidemiology"," "," "," ",null," "," "," "]
["https://doi.org/10.25122/jml-2021-0152","Anwar Madlool Al-Janabi et al. (2021)","case-control genetic epidemiology ",null,null," ",null," "," "]
["https://doi.org/10.1038/s41598-021-01876-1","Pavlenkova, Z. et al. (2021)","cross-sectional design",null,null," ",null," "," "]
["https://doi.org/10.1177/00469580211055571","Bian, P. et al. (2022)","Cross-sectional ",null,null," ",null," "," "," "]
["https://doi.org/10.1186/s12920-022-01201-3","Fu, Y. et al. (2022)","Cross-sectional ",null," "," ",null," "," "," "]
["https://doi.org/10.1007/s00439-021-02368-y","Kyung Seok Oh. et al. (2022)","phenotype-genotype study ",null," "," ",null,null," "," "]
["https://doi.org/10.5152/iao.2022.21220","Wang, Y. et al. (2022)","Cross-sectional ",null,null," ",null," "," "," "]
["https://doi.org/10.1136/jmedgenet-2020-107594","Bong Jik Kin. Et al. (2022)","Prospective observational study"," ",null," ",null,null," "," "]
["https://doi.org/10.1016/j.neurobiolaging.2021.12.004","Bally JF. et al. (2022)","prospective cohort study"," ",null," ",{"$nulls":3}," "]
["https://doi.org/10.1007/s11033-022-07245-z","AitRaise, I. et al. (2022)","descriptive observational design "," ",null," ",null," ",null," "]
["https://doi.org/10.3390/ijms23116029","Ozięelo, D. et al. (2022)","Cross-sectional "," ",null," ",null,null," "," "]
["https://doi.org/10.7717/peerj.14514","Petrova, N. et al. (2023)","Cross-sectional "," ",null," ",null," "," "," "]
["https://doi.org/10.1038/s41439-019-0068-4","Ganaha, A. et al. 2019","Family-based genetic study"," ",null," ",null,null," "," "]
["https://doi.org/10.1002/mgg3.2015","Kabahuma, RI. et al. (2022)","genetic association study"," "," "," ",null," "," "," "]
["https://doi.org/10.1002/jcla.24896","Lan, Ying. Et al.. (2023)","case-control genetic association study ",null,null," ",null," "," "]
["https://doi.org/10.1016/j.ijporl.2023.111635","Li, W. et al. (2023)","genetic association study",null,null," ",null," "," "]
["https://doi.org/10.1016/j.ekir.2023.07.010","Solanki, KV. Et al. (2023)","genetic association study",null," "," ",null," ",null," "]
["https://doi.org/10.1016/j.jmoldx.2023.07.005","Chiang, Yu-Ting. Et al. (2023)","genetic association study",null,null," "]
["https://doi.org/10.1016/j.heliyon.2023.e21185","Tian, Y. et al. (2023)","comparative cross-sectional genetic association study",null,null," ",null," ",null," "]
["https://doi.org/10.3390/ijms242316763","Sakata, A. et al. (2023)","retrospective longitudinal cohort stufy",null,null," ",{"$nulls":3}," "]
["https://doi.org/10.1002/mgg3.741","Shang, S. et al. (2019)","family-based observational genotype–phenotype correlation study"," ",null," ",null,null," "]
["https://doi.org/10.3390/genes10060429","Posukh, Olga L. et al. (2019)","Observational cross-sectional study with comparison to ethnically matched controls."," ",null," ",null," "," "," "]
["https://doi.org/10.3389/fgene.2019.00501","Elayne E Santana. Et al. (2019)","cross-sectional genetic study",null,null," ",null,null," "]
["https://doi.org/10.1371/journal.pone.0215932","Yoh-Ichiro Iwasa. Et al. (2019)","cross-sectional genetic screening study"," ",null," ",null," "," "," "]
["https://doi.org/10.1080/13816810.2019.1571615","Pablo T Romero. Et al. (2019)","clinical-genetic case series",null,null," ",null,null," "," "]
["https://pubmed.ncbi.nlm.nih.gov/30942159/","Xiao, Shu-Ying. Et al. (2019)","family-based genetic observational study"," ",null," "]
["https://doi.org/10.1038/s41598-019-40586-7","Yokota, Y. et al. (2019)","Cross-sectional "," "," "," ",null," "," "," "]
["https://doi.org/10.3389/fgene.2019.00076","Gallego-Martinez, A. et al. (2019)","cross-sectional, observational genetic case-control study"," "," "," ",null," "," "]
["https://doi.org/10.1371/journal.pone.0211261","Liu, Wei-Hsiu","cross-sectional observational genetic study"," ",null," ",null,null," "]
["https://doi.org/10.1016/j.amjoto.2018.07.022","Azadegan-Dehkordi, F. et al. (2018)","genetic cohort study"," ",null," ",null," "," "]
["https://doi.org/10.1007/s00405-018-5083-4","Kecskeméti, N. et al. (2018)","observational genetic cohort study"," "," "," ",null," "," "," "]
["https://doi.org/10.1186/s13104-018-3647-4","Carvalho, S. et al. (2018)","cross-sectional genetic screening study",null," "," ",null," "," "]
["https://doi.org/10.1186/s12881-018-0585-x","Nonose, R. et al. (2018)","cross-sectional molecular genetics study",null," "," ",null," "," "," "]
["https://doi.org/10.3390/medicina54020028","Plevova, P. et al. (2018)","observational genetic cross-sectional study"," ",null," ",null," "," "]
["https://doi.org/10.1016/j.ijporl.2018.01.006","Asgharzade, S. et al. (2018)","observational genetic study"," ",null," ",null," "," "," "]
["https://doi.org/10.1007/s00508-017-1230-y","Parzefall, T. et al. (2018)","observational family-based genetic study"," ",null," ",null," "," "]
["https://doi.org/10.1007/s00439-018-1885-0","Li, W. et al. (2018)","observational genetic linkage family-based study"," "," "," ",null," "," "," "]
["https://doi.org/10.1016/j.ijporl.2017.09.001","Huang, S. et al. (2017)","observational, cross-sectional genetic association study"," ",null," ",{"$nulls":3}," "]
["https://doi.org/10.1089/gtmb.2017.0130","Tlili, A. et al. (2017)","observational genetic prevalence study"," ",null," ",null," "," "]
["https://doi.org/10.1016/j.heares.2017.09.013","Kytövuori, L. et al. 2017","genetic association and family segregation study",null,null," ",null," "," "]
["https://doi.org/10.1111/ahg.12207","Luo, J. et al. 2017","observational, cross-sectional genetic screening study",null," "," ",null," "," "]
["https://doi.org/10.3390/ijms18112246","Ah Reum Kim, et al. (2017_","genetic observational study with functional validation",null,null," ",null,null," "]
["https://doi.org/10.1089/gtmb.2016.0051","Chen, S. et al. 2016","observational, cross-sectional genetic study"," ",null," ",null," "," "]
["https://doi.org/10.1038/srep34425","Wang, H. et al. (2017)","family-based genetic study"," "," "," ",null," "," "," "]
["https://doi.org/10.1016/j.bjorl.2017.10.013","Felix, F. et al. (2017)","observational, cross-sectional genetic study",null,null," ",null," "," "]
["https://doi.org/10.1186/s13023-017-0708-z","Yamamoto, N. et al. (2017)","observational, cross-sectional genetic prevalence study"," ",null," ",null," "," "]
["https://doi.org/10.1371/journal.pone.0185281","Tlili, A. et al. (2017)","observational, descriptive, molecular genetics study"," "," "," ",null," "," "," "]
["https://doi.org/10.1016/j.ijporl.2017.06.008","Niu, Z. et al. 2017","family-based observational genetic study"," "," "," ",null,null," "," "]
["https://doi.org/10.1038/s41598-017-08236-y","Lin, Yin-Hung, et al. (2017)","family-based genetic study with functional validation"," ",null," ",null," "," "]
["https://doi.org/10.1371/journal.pone.0177636","Kitano, T. et al. (2017)","observational genetic screening study"," ",null," ",{"$nulls":3}," "]
["https://doi.org/10.1080/00016489.2016.1249946","Parzefall, T. et al. (2017)","observational genetic association study",null,null," ",null," "," "]
["https://doi.org/10.1186/s12881-017-0396-5","Huang, B. et al. (2017)","family-based genetic observational study"," "," "," ",null,null," "," "]
["https://doi.org/10.1016/j.amjoto.2024.104573","Deng, L. et al. (2025)","retrospective cohort study",null,null," ",null," ",null," "]
["https://doi.org/10.1038/s41439-019-0075-5","Ito, T. et al. (2019)","observational genetic screening study"," ",null," ",null," "," "]
["https://doi.org/10.1186/s40246-023-00556-7","Peart, L. et al. (2023)","retrospective chart review (observational study)",null,null," ",null," "," "," "]
["https://doi.org/10.1167/iovs.64.10.23","Stephenson, Kirk A J. et al. (2023)","retrospective observational cohort study"," ",null," ",null,null," "," "]
["https://doi.org/10.1001/jamaoto.2022.4463","Carlson, Ryan J. et al. (2023)","combined cross-sectional and retrospective cohort study"," ",null," ",null,null," "," "]
["https://doi.org/10.1007/s13353-021-00674-9","Lin, K. et al. (2022)","combined family-based sequencing, candidate gene analysis and bioinformatics integration",null,null," ",null,null," "]
["https://doi.org/10.1007/s00439-021-02424-7","Thorpe, Ryan K. et al. (2022)","retrospective observational study of human audiometric data"," ",null," ",null,null," "," "]
["https://doi.org/10.1177/01945998211029544","Ahmadmehrabi, S. et al. (2022)","genomic association study",null,null," ",null," "," "," "]
["https://doi.org/10.1016/j.ijporl.2021.110975","Nakano, A. et al. (2022)","retrospective observational study ",null," "," ",{"$nulls":3}," "]
["https://doi.org/10.1016/j.ejmg.2021.104311","Guan, J. et al. (2021)","observational genetic study"," ",null," ",null," "," "]
["https://doi.org/10.1186/s12881-018-0630-9","Su, Y. et al. (2018)","observational genetic study with clinical and molecular characterisation"," ",null," ",null,null," "," "]
["https://doi.org/10.1002/mgg3.394","Wang, H. et al. (2018)","Observational, descriptive, family-based genetic study."," ",null," ",null," "]
["https://doi.org/10.1016/j.ijporl.2017.07.042","Aimoni, C. et al. (2017)","retrospective observational study ",null,null," "]
["https://doi.org/10.1007/s00467-016-3573-4","Martine T P Besouw et al. (2017)","single-centre, retrospective obsrrvational study",null,null," ",null,null," "," "]
["https://doi.org/10.1038/jhg.2017.42","Elena A Bliznetz. Et al. (2017)","genetic epidemiology study combining molecular genetics, population genetics, and clinical phenotyping"," ",null," ",null,null," "," "]
["https://doi.org/10.5582/bst.2017.01070","Du, Y. et al. (2017)","retrospective study",null,null," ",{"$nulls":3}," "]
["10.1007/s00405-016-3954-0","Koichiro Wasano (2016)","observational, single-family case series ",null,null," ",null,null," "," "]
["10.1371/journal.pone.0165680","Kim (2016)","Observational genetic epidemiologic study with cohort and family-based analysis.",null,null," ",null," "," "]
["10.1590/1678-4685-GMB-2015-0218","Liu, Y. et al. (2016)","obvservational, cross-sectional study"," ",null," ",null," "," "]
["10.2147/TACG.S113828","Anastasia M Fedick (2016)","Genetic case study with family-based segregation analysis and population carrier frequency assessment.",null,null," ",null," "," "," "]
["10.1089/omi.2016.0067","Caroça, C. et al. (2016)","observational, case-control genetic association study",null,null," ",null,null," "]
["10.1590/2359-3997000000108","Chunyun Fu (2016)","observational, cross-sectional genetic screening study"," "," "," ",null," ",null," "]
["10.1016/j.ijporl.2016.02.024","Chen (2016)","case-control study (observational, analytical)",null,null," ",null," "]
["10.1007/s00405-015-3684-8","Mahdieh(2015)","observational, cross-sectional genetic study"," ",null," ",null," "," "," "]
["10.1007/s00405-015-3661-2","Choi (2015)","observational genetic study with family-based analysis "," ",null," ",null," "," "," "]
["10.1016/j.ijporl.2016.01.001","Ma et al., 2016","family-based genetic observational study"," ",null," ",null," "," "]
["10.1007/s10048-016-0477-1","Imtiaz, A. et al. (2016)","Observational genetic study ",null," "," ",{"$nulls":3}," "]
["10.3892/mmr.2016.4871","Lin, X. et al. (2016)","case-control genetic association study ",null," "," ",null," "," "]
["10.1186/s12863-016-0354-9","Mikstiene, V. et al. (2016)","Cross-sectional "," ",null," ",null," "," "]
["10.1186/s12863-016-0333-1","Yuan, Y. et al. (2016)","Family-based genetic study"," "," "," ",null,null," "," "]
["10.1016/j.gene.2015.06.038","Dai, Z. et al. (2015)","Observational case series",null,null," "]
["10.1002/ajmg.a.37206","Gao, X. et al. (2015)","Observational genetic study, family-based cohort study"," ",null," ",null," "," "]
["10.1016/j.ajhg.2015.07.014","Tanaka, AJ. et al. (2015)","Observational genetic study",null,null," "]
["10.1007/s00405-014-3171-7","Zeinali, S. et al. (2014)","observational genetic screening study"," ",null," ",null," ",null," "]
["10.5152/iao.2015.1212","Bozdoğan, ST. et al. (2015)","cross-sectional observational genetic study",null,null," ",null," "," "]
["10.1016/j.ijporl.2015.06.009","Pang, X. et al. (2015)","case-control genetic association study ",{"$nulls":4}," "," "]
["10.1007/s00438-015-0995-9","Chakchouk, I. et al. (2015)","family-based observational genetic study"," "," "," ",null," "," "]
["10.1007/s00405-014-2970-1","Martines, F. et al. (2014)","observational genetic study",null,null," ",null," "," "]
["10.1038/jhg.2015.19","Sun, Y. et al. (2015)","genetic observational study"," "," "," ",null," "," "," "]
["10.1016/j.gene.2015.02.022","Frykholm, C. et al. (2015)","observational genetic study"," "," ",null,null," ",null," "]
["10.1186/s13023-015-0276-z","Mizutari, K. et al. (2015)","Observational, cross-sectional genetic study with retrospective and prospective components"," ",null," ",null," "," "]
["10.1186/s12967-015-0483-3","Huang (2015)","Observational familial genetic case study",null,null," "]
["10.1177/0003489415575061","Mori (2015)","Observational cohort genetic study with case report elements",null,null," "]
["10.1177/0003489415575057","Miyagawa(2015)","Observational cohort genetic study",null,null," "]
["10.1177/0003489415575056","Miyagawa (2015)","Observational cohort genetic study",null,null," "]
["10.1111/cge.12437","Chaussenot A (2014)","Observational cohort genetic study"," ",null," ",null," "]
["10.1371/journal.pone.0124232","Mašindová (2015)","Observational genetic prevalence study",null,null," "]
["10.1007/s00439-015-1532-y","Nayak(2015)","Observational genetic cohort study",null," "," ",null,null," "]
["10.1038/jhg.2014.114","Wang (2015)","Observational genetic family study"," "," "," ",null,null," "]
["10.1371/journal.pone.0116931","Kim(2015)","Observational genetic family study",null,null," ",null," ",null," "]
["10.3109/14992027.2014.944276","Yazdanpanahi(2014)","Descriptive laboratory study",null," "," ",null,null," "]
["10.1111/cge.12332","Vona(2015)","Observational molecular genetic study (cross-sectional design)",null,null," ",null,null," "," "]
["10.1016/j.jns.2015.04.038","Ahmed et al., 2015","Observational genetic case study / family-based molecular study (descriptive, cross-sectional design)"," ",null," ",null," "," "," "]
["10.1089/gtmb.2014.0241","Qing et al., 2015","Observational cross-sectional genetic study",null,null," ",null,null," "," "]
["10.1159/000366514","Kim et al., 2015","Observational genetic cohort study of two families",null,null," ",null," "," "]
["10.1089/gtmb.2014.0185","Stanghellini et al., 2014","Retrospective observational genetic study",null,null," ",null," "," "]
["10.1002/ajmg.a.36760","Bai et al., 2014","Family-based genetic study (observational)"," ",null," ",null," "," "]
["10.1089/omi.2014.0063","Bosch et al., 2014","Observational genetic study (cross-sectional / sequencing-based)",null,null," ",null," "," "]
["10.3109/00016489.2014.927588","Xu et al., 2014","Observational genetic study (cross-sectional / descriptive)",null,null," ",null,null," "]
["10.1002/lary.24697","Javidnia et al., 2014","Observational",null,null," ",null,null," "]
["10.1371/journal.pone.0103133","Wang et al., 2014","Observational, Family-based/cohort"," ",null," ",null," "," "]
["10.1007/s12041-014-0365-0","Neocleaus et al., 2014","cross-sectional observational genetic study",null,null," ",null," "," "]
["10.3109/14992027.2014.905717","Salvago et al., 2014","Population Study "," ",null," ",null," "," "]
["10.1111/cge.12247","Webb et al., 2014","family genetic study, cross-sectional population study"," ",null," ",null," "," "," "]
["10.1016/j.ijporl.2014.03.033","Jin et al., 2014","observational genetic study with both cohort and family case components"," ",null," ",null," "," "," "]
["10.1016/j.ijporl.2014.04.002","Loeza-Becerra et al., 2014","cross-sectional genetic prevalence study",null,null," ",null," "," "]
["10.3892/mmr.2014.2148","Jiang et al., 2014","cross-sectional study describing genetic mutation prevalence and distribution in a defined cohort",null,null," ",null," "," "]
["10.3109/00016489.2014.890740","Ishikawa et al., 2014","family-based observational genetic case study (or case series)",null,null," ",null," "," "]
["10.1007/s00109-014-1128-3","Chung et al., 2014","cross-sectional observational genetic study with genotype-phenotype correlation",null,null," ",null,null," "]
["10.7717/peerj.384","Pique et al., 2014","genetic observational study with targeted mutation screening",null,null," ",null," "," "]
["10.1097/MAO.0000000000000238","Chien et al., 2014","Case series"," "," "," ",null," "," "," "]
["10.1016/j.ijporl.2014.01.022","Bonyadi et al., 2014","cross-sectional genetic prevalence study",null,null," ",null," "," "]
["10.1016/j.ijporl.2014.01.011","Chai et al., 2014","cross-sectional genetic observational study",null,null," ",null,null," "]
["10.3109/00016489.2013.849817","Du et al., 2014","cross-sectional genetic observational study"]
["10.1371/journal.pone.0090688","Yoshimura et al., 2014","cross-sectional genetic observational study",null,null," "]
["10.1155/2014/746838","Du et al., 2014","cross-sectional genetic observational study",null,null," ",null," "," "," "]
["10.1159/000356681","Zhang et al., 2014","family-based case series / pedigree analysis",null,null," ",null," "]
["10.1159/000356303","Beelen et al., 2014 ","Case series",null,null," ",null," "," "]
["10.1111/cge.12074","Rendorff et al., 2013","cross-sectional observational study",null,null," ",null," "," "," "]
["10.1001/jamaoto.2013.4185","Chattaraj et al., 2013","prospective cross-sectional cohort study",null,null," "]
["10.1016/j.ijporl.2013.06.015","Riah et al., 2013","Case series"," ",null," ",null," "]
["10.1016/j.ijporl.2013.06.017","Huang et al., 2014"," single-patient case report with molecular genetic analysis"," ",null," ",null," "]
["10.1177/0194599813493075","Shahzad et al., 2013","prospective genetic linkage and sequencing study in families (molecular epidemiology study)",null,null," ",null,null," "]
["10.1186/1471-2350-14-85","Landa et al., 2013","genetic association / mutation screening study (cross-sectional laboratory-based study)",null,null," ",null,null," "]
["10.1007/s10528-013-9583-z","Bukhari et al., 2013","cross-sectional genetic epidemiology / mutation prevalence study",null,null," ",null," "," "]
["10.1371/journal.pone.0070134","Li et al., 2013","family-based genetic linkage and mutation analysis study (observational, molecular genetics study)",null," "," ",null,null," "," "]
["10.1111/jcmm.12080","Gao et al., 2013","Laboratory-based experimental mechanistic study"," "," ",{"$nulls":3}," "]
["10.3109/14992027.2013.783719","Matos et al., 2013","Observational, cross-sectional genetic study"," ",null," ",null," "," "," "]
["10.1186/1750-1172-8-85","Yang et al., 2013","Prospective genetic cohort study",null,null," ",{"$nulls":3}," "]
["10.1097/MAO.0b013e31828d6501","Ramsebner et al., 2013","Genetic association study (case-control type within families and populations)",null,null," ",null,null," "]
["10.3174/ajnr.A3367","Elmaleh-Bergès et al., 2013","Retrospective observational study",null,null," "]
["10.1186/1471-2350-14-56","Ganaha et al., 2013","Observational genetic study (cross-sectional, descriptive, molecular analysis)",null,null," ",null,null," "]
["10.1371/journal.pone.0063231","Naito et al., 2013","Observational, population-based genetic study",null," "," "]
["10.1016/j.amjoto.2012.11.002","Gallant et al., 2013","Observational, family-based genetic linkage and sequencing study",{"$nulls":5}," "]
["10.1371/journal.pone.0061592","Kim et al., 2013","Observational, cross-sectional genetic prevalence study",{"$nulls":6}," "]
["10.1161/CIRCGENETICS.112.964684","Giudicessi et al., 2013","Retrospective observational cohort study"]
["10.1002/art.37810","Kuemmerle-Deschner et al., 2013","Prospective observational cohort study"]
["10.1073/pnas.1222285110","Yan et al., 2013","Genetic linkage and functional experimental study"]
["10.1002/humu.22232","Choi et al., 2013","Molecular and functional in vitro study"]
["10.1111/j.1399-0004.2012.01884.x","Husu et al., 2013","Retrospective nationwide descriptive study"]
["10.4067/S0716-97602013000300003","Cifuentes et al., 2013","Cross-sectional genetic prevalence study"]
["10.33549/physiolres.932475","Groh et al., 2013","Observational cross-sectional study"]
["10.1371/journal.pone.0057369","Wu et al., 2013","Observational genetic study / diagnostic cohort study"]
["10.1371/journal.pone.0055178","Sang et al., 2013","Family-based genetic linkage and molecular characterization study"]
["10.1016/j.gene.2012.09.023","Lezirovitz et al., 2012","Family-based genetic linkage and molecular functional study"]
["10.1007/s11033-012-1929-9","Hashemi et al., 2012","Cross-sectional genetic prevalence study"]
["10.1007/s11033-012-2003-3","Charif et al., 2012","Cross-sectional genetic prevalence study"]
["10.1002/ajmg.a.35572","Babanejad et al., 2012","Genetic mapping and mutation screening study (cross-sectional, family-based)"]
["10.1017/S0022215112001119","Battelino, S. et al. (2012)","Cross-sectional genetic association study"]
["10.3109/00016489.2012.669498","Löppönen T et al. / 2012","Observational familial case series with retrospective review and systematic follow-up"]
["10.1016/j.gene.2012.03.060","Minami SB et al. / 2012","Observational familial genetic case study"]
["10.3109/14992027.2012.660575","Homøe P et al. / 2012","Prospective observational genetic study"]
["10.1007/s00405-011-1817-2","Popova DP et al. / 2012","Prospective observational genetic study"]
["10.1016/j.ijporl.2011.12.020","Minárik G et al. / 2012","Observational genetic study / cross-sectional mutation screening"]
["10.1007/s00439-011-1083-9","Taokesen M et al. / 2011","Observational genetic study / case report of a familial kindred"]
["10.1016/j.ijporl.2011.11.019","Davarnia B et al. / 2012","Observational genetic study focused on mutation screening"]
["10.1016/j.ijporl.2011.11.009","Qu C et al. / 2012","Observational cross-sectional genetic study"]
["10.1371/journal.pone.0051566","Khateb S et al. / 2012","Observational genetic study using a combined approach of homozygosity mapping and whole exome sequencing (WES)"]
["10.1371/journal.pone.0049984","Yuan Y et al. / 2012","Observational, cross-sectional, genetic epidemiology study"]
["10.1371/journal.pone.0036354","Danilenko N et al. / 2012","Observational, cross-sectional genetic study comparing two cohorts:"]
["10.1371/journal.pone.0030720","Yuan Y et al. / 2012","Observational genetic cohort study (cross-sectional design)"]
["10.1136/jmedgenet-2011-100468","Le Quesne Stabej P et al. / 2012","Observational genetic cohort study (cross-sectional design)"]
["10.1186/1750-1172-6-88","Swinnen FKR et al. / 2011","Observational cross-sectional and family-based study"]
["10.3109/14992027.2011.603757","Chinetti V et al. / 2011","Observational cross-sectional genetic study (neonatal cohort)"]
["10.1186/1479-5876-9-167","Huang S et al. / 2011","Observational cross-sectional genetic association study"]
["10.1186/1479-5876-9-154","Chen Y et al. / 2011","Observational cross-sectional comparative genetic study"]
["10.1016/S1674-8301(11)60042-0","Lu et al. / 2011","Observational cross-sectional genetic study"]
["10.1016/j.ijporl.2011.06.011","Chen  et al. / 2011","Observational cross-sectional genetic study"]
["10.1038/jhg.2011.72","Yoong SY et al. / 2011","Observational, cross-sectional, genetic association study in a population isolate"]
["10.1136/adc.2010.209262","Zhao F-F et al. / 2011","Retrospective cohort study"]
["10.1089/gtmb.2010.0192","Hildebrand MS et al. / 2011","Observational, cross-sectional study"]
["10.1002/humu.21512","Rezaei H, Vallian S / 2011","genetic cohort study"]
["10.1007/s10571-011-9683-4","Pauw RJ et al. / 2011","Observational, cross-sectional genetic study"]
["10.1177/000348941112000612","Chen Y et al. / 2011","Retrospective observational study (family-based genotype–phenotype study)"]
["10.1002/lary.21751","Kabahuma RI et al. / 2011","Prospective cohort study"]
["10.1016/j.ijporl.2011.01.029","Zhang J et al. / 2011","Observational, cross-sectional genetic prevalence study"]
["10.1089/gtmb.2010.0182","al-Achkar W et al. / 2011","Observational, cross-sectional genetic association study"]
["10.3892/mmr.2011.428","Sun Y et al. / 2011","Observational, cross-sectional genetic prevalence study"]
["10.1016/j.jcg.2011.01.001","Sun et al. / 2011","Observational genetic study (family-based linkage study + sporadic patient screening)"]
["10.3109/00016489.2010.483479","Jones SM et al. / 2011","Observational cross-sectional genetic prevalence study"]
["10.1007/s11033-010-0231-y","Elia A et al. / 2011","Observational genetic prevalence study (cross-sectional)"]
["10.1001/archoto.2010.234","Sun Y et al. / 2011","Prospective observational genetic family study"]
["10.1038/jhg.2010.147","Chan DK et al. / 2011","Observational genetic family study (case series with linkage analysis)"]
["10.1097/MAO.0b013e3181fc786f","Radulescu L et al. / 2011","Retrospective observational case series"]
["10.1159/000320192","Tsukada K et al. / 2010","Observational genetic case series / cohort study"]
["10.1111/j.1399-0004.2010.01407.x","Teek R et al. / 2010","Large-scale observational genetic association study (cross-sectional / cohort description)"]
["10.1016/j.ijporl.2010.05.026","Cengiz FB et al. / 2010","Observational, cross-sectional familial genetic study"]
["10.1089/gtmb.2010.0039","Hochman JB et al. / 2010","Observational, cross-sectional genetic prevalence study"]
["10.1097/MAO.0b013e3181e3d324","Cordeiro-Silva MF et al. / 2010","Observational, cross-sectional genetic prevalence study"]
["10.1590/S1808-86942010000400004","Pourová R et al. / 2010","Observational, cross-sectional genetic prevalence study"]
["10.1111/j.1469-1809.2010.00581.x","Chen H et al. / 2010","Observational, cross-sectional genetic and phenotypic study"]
["10.1016/j.bbrc.2010.05.066","Chen H et al. / 2010","Observational, cross-sectional familial genetic study"]
["10.1016/j.ijporl.2010.03.004","Shan et al./2010","Observational, cross-sectional genetic prevalence study"]
["10.3390/genes1010023","Sand et al./2010","Observational, cross-sectional genetic association study"]
["10.3109/14992021003601756","Franzè et al./2010","Observational, cross-sectional genetic screening study"]
["10.1016/j.ijporl.2009.12.015","Lazăr et al./2010","Observational, cross-sectional genetic prevalence study"]
["10.1159/000297216","Bartsch et al./2010","Observational, cross-sectional and retrospective cohort study"]
["10.1001/archoto.2009.202","Kenna et al./2010","Prospective observational cohort study"]
["10.1002/ajmg.a.33114","Campbell et al./2010","Observational, case-control genetic association study"]
["10.1159/000255339","Topsakal et al./2010","Observational, familial cohort study (genetic/phenotype correlation)"]
["10.1159/000254487","Dalamón et al./2010","Observational, genetic screening study"]
["10.1002/lary.20691","Fujikawa et al./2010","Observational, family-based genetic study"]
["10.1002/lary.20621","Wu et al./2009","Observational, diagnostic development and validation study"]
["10.1089/gtmb.2009.0044","Kunishima et al./2009","Observational, genetic screening study"]
["10.1016/j.ijporl.2009.06.009","Dietz et al./2009","Observational, retrospective cohort study"]
["10.1152/physiolgenomics.00047.2009","Dai et al./2009","Observational, genetic screening + functional validation study"]
["10.1016/j.bbrc.2009.05.083","Bhalla et al./2009","Observational, genetic screening study"]
["10.1111/j.1399-0004.2009.01183.x","Sırmacı et al./2009","Observational, genetic epidemiology study"]
["10.1177/000348940911800511","de Heer et al./2009","Observational, family-based genetic study"]
["10.1038/jhg.2009.21","Anwar et al./2009","Genetic epidemiology study in consanguineous families"]
["10.1038/ejhg.2008.231","Doucette et al./2009","family-based genetic linkage and candidate gene sequencing study"]
["10.1177/000348940911800413","de Heer et al./2009","Observational family-based genetic study with cross-sectional analysis of hearing and vestibular function"]
["10.1111/j.1749-4486.2009.01888.x","Bajaj et al./2009","Cross-sectional survey"]
["10.1016/j.mrfmmm.2008.11.019","Wang et al./2009","Family/Genetic linkage and mutation analysis study"]
["10.1016/j.ijporl.2008.11.010","Joseph & Rasool/2009","Mutation detection and haplotype analysis"]
["10.1017/S0022215108002892","Khandelwal et al./2009","Case-control study"]
["10.1016/j.ijporl.2008.10.002","Fischer et al./2009","Retrospective case series review"]
["10.1016/j.ijporl.2008.10.001","Tamayo, ML. et al. 2009","Pilot screening program (cross-sectional genetic study)"]
["10.1097/GIM.0b013e318187e106","Hildebrand et al./2008","Audioprofile-directed mutation screening"]
["10.1097/MLG.0b013e31817fb7ad","Angeli/2008","Prospective cohort study"]
["10.1097/MAO.0b013e3181825651","Kallman et al./2008","Family study/Genetic modifier analysis"]
["10.1111/j.1749-4486.2008.01754.x","Bajaj et al./2008","Cross-sectional survey"]
["10.1016/j.ajhg.2008.07.008","Ruel et al./2008","Linkage analysis and candidate gene study/Mouse model functional analysis"]
["10.1097/gim.0b013e31817d2ef1","Dai et al./2008","Population screening/Prevalence study"]
["10.1186/1471-2350-9-48","Evirgen et al./2008","Cross-sectional genotyping study"]
["10.1089/gte.2007.0106","Bramhall et al./2008","Family/Genetic and audiovestibular analysis study"]
["10.1016/j.heares.2008.03.004","Matos et al./2008","Research paper/Family study/In vitro functional studies"]
["10.1089/gte.2007.0107","Auslender et al./2008","Family/Linkage and mutation analysis study"]
["10.1001/archotol.134.4.403","Brownstein, ZN. et al. (2008)","Experimental Design (audiometric analysis)"]
["10.1001/archotol.134.3.294","Pauw, RJ. et al. (2008)","Case report/Case-control screening"]
["10.1002/ajmg.a.32078","Doherty, ES. et al (2007)","Experimental Design (Audiometric analysis)"]
["10.1111/j.1399-0004.2007.00833.x","Wagatsuma, M. et al (2007)","Experimental Design (Audiometric analysis)"]
["10.1002/ajmg.a.31718","Meyer, NC. et al (2007)","Experimental Design (Audiometric analysis)"]
["10.1097/gim.0b013e3180a03276","Putcha, GV. Et al (2007)","Multicenter Retrospective cohort study"]
["10.1186/1471-2350-8-26","Tsai, HT. et al (2007)","Experimental Design (Audiometric analysis)"]
["10.1007/s10162-006-0060-9","Plantinga, RF. Et al (2006)","Experimental Design (Audiometric analysis)"]
["10.1111/j.1399-0004.2007.00739.x","Kitajiri, S. et al (2007)","Experimental Design (Audiometric analysis)"]
["10.1007/s10038-007-0144-3","Fukuoka, H. et al (2007)","Cross-sectional genetic screening study"]
["10.1007/BF02935334","Sirmaci A, Akcayoz-Duman D, Tekin M (2006)","Cross-sectional genetic screening study"]
["10.1002/ajmg.a.31525","Tang, Hsiao-Yuan. et al (2006)","Cross-sectional sequencing study"]
["10.1136/jmg.2006.041954","Seeman P, Skmaryova (2006)","National/Clinical study"]
["10.1136/jmg.2005.034892","Eiberg,  H.et al (2006)","Family study/linkage analysis"]
["10.1002/humu.9044","Kupka, S. et al (2002)","Cross-sectional genetic screening"]
["10.1038/sj.ejhg.5200826","Frei, K. et al (2002)","Cross-sectional genetic study"]
["10.1007/s00439-002-0719-1","Cryns, K. et al (2001)","Multi-family study"]
["10.1002/humu.9033","Najmabadi, H. et al (2002)","Cross-sectional genetic study"]
["10.1177/000348940211100312","Leenheer, EMRD. et al (2002)","Family study"]
["10.1002/humu.10049","Brederlow, BV. et al (2002)","Case report"]
["10.1007/s100380200057","Komatsu, K. et al (2002)","Family study/genome wide linkage analysis study"]
["10.1093/hmg/10.22.2501","Bespalova, IN. et al (2001)","Gene discovery study"]
["10.1001/archotol.127.9.1037","Kenna, MA. et al (2001)","Prospective clinical study"]
["10.5694/j.1326-5377.2001.tb143093.x","Dahl, HH. et al (2001)","Experimental Design (Audiometric analysis)"]
["10.1002/humu.37","Kamarinos, M. et al (2001)","Family-based genetic linkage study"]
["10.1038/sj.ejhg.5200607","Loffler, J. et al (2001)","Cross sectional study"]
["10.1001/archotol.127.1.13","Leenheer, EMRD. et al (2001)","Cross-sectional/Family study"]
["10.1086/316954","Bork, JM. et al (2001)","Gene discovery"]
["10.1097/00005537-200008000-00030","Khetarpal, U (2009)","Prospective vestibular testing"]
["10.1076/1381-6810(200006)2121-8FT123","Beneyto, M. et al (2000)","Cross sectional genetic epidemiology"]
["10.1001/archotol.126.5.633","Frydman, M. et al (2000)","Family-based Case Series"]
["10.1007/s004390000273","Wilcox, SA. et al (2000)","Cross-sectional genetic epidemiology"]
["10.1097/00005537-200003000-00025","Admiraal, RJC. et al (2009)","Familial based case series"]
["10.1002/(sici)1096-8628(20000117)90:2<141::aid-ajmg10>3.0.co;2-g","Kudo, T. et al (2000)","Cross-sectional genetic epidemiology"]
["10.1007/s004390051007","Rabionet, R. et al (1999)","Cross-sectional genetic epidemiology"]
["10.1002/1098-1004(200007)16:1<7::AID-HUMU2>3.0.CO;2-A","Antoniadi, T. et al (2000)","Cross-sectional genetic epidemiology"]
["10.3109/03005369909090112","Orzan, E. et al. (2009)","Experimental Design (Screening analysis, audiometric)"]
["10.1097/00005537-199909000-00031","Bom, SJH. et al (2009)","Family based case series"]
["10.1093/hmg/8.8.1425","Fransen, E. et al (1999)","Family based case series"]
["10.1001/jama.281.23.2211","Green, GE. et al (1999)","Cross-sectional genetic epidemiology"]
["10.1002/(SICI)1098-1004(199912)14:6<493::AID-HUMU8>3.0.CO;2-P","Talebizadeh, Z. et al (1999)","Family based case series"]
["10.1006/mcpr.1997.0149","Wang, C. et al (1998)","Family based case series"]
["10.1002/(SICI)1098-1004(1998)11:5<387::AID-HUMU6>3.0.CO;2-8","Scott, DA. et al (1999)","Cross-sectional genetic epidemiology"]
["10.1097/00005537-199607000-00021","Lalwani, K. et al (1996)","Family based case series"]
["10.1080/00016489.2025.2479632","Li, Y. et al (2025)","Experimental functional analysis"]
["10.3390/genes15111451","Alsebeyi, M. et al (2024)","Family based case series"]
["10.1002/ohn.1200","Wang, Y. et al (2025)","Experimental Design (Screening analysis and audiometric analysis)"]
["10.1016/j.gene.2023.147335","Lee, SJ. Et al (2023)","Experimental Design (Screening analysis and structural modeling)"]
[" 10.1186/s12920-024-02023-1","Du, Q. et al (2024)","Family based case series"]
["10.46903/gjms/21.02.1189","Ukaegbu, M. et al (2023)","Cross-sectional genetic epidemiology"]
["10.3390/jcm11071837","Kraatari-Tiri, M. et al (2022)","Family based case series"]
["10.26650/IUITFD.1011501","Güleç, Ç. Et al  (2022)","Cross-sectional genetic epidemiology"]
["10.3389/fgene.2021.643546","Zhang, S. et al (2021)","Family based case series"]
["10.1159/000513607","Li, Y. et al (2021)","Family based case series"]
["10.1134/S1022795422050106","Stepanova, AA. Et al (2021)","Cross-sectional genetic epidemiology"]
["10.3390/genes10100735","Maekawa, K. et al (2019)","Cross-sectional genetic epidemiology"]
["10.1038/s41431-021-00820-1","Nash, BM. Et al (2021)","Family based case series"]
["10.3390/genes11101233","Buonfiglio, P. et al (2020)","Experimental Design (Screening analysis)"]
["10.3390/ijms20174174","Lee, SY. Et al (2019)","Family based case series"]
["10.14715/cmb/2019.65.3.12","Xiao, SY. Et al (2019)","Experimental Design (Bioinformatic analysis)"]
["10.5152/TurkPediatriArs.2017.4254","Subaşıoğlu, A. et al (2017)","Experimental Design (Screening analysis)"]
["10.1590/1678-4685-gmb-2017-0318","Xia, H. et al (2019)","Single-case family report"]
["10.1155/2016/5310192","Gu, X. et al (2016)","Family based case series"]
["10.1371/journal.pone.0129662","Huang, S. et al (2015)","Experimental Design (Screening analysis)"]
["10.1186/s12881-016-0269-3","Ryu, N. et al (2016)","Gene Screen/case series"]
["10.4103/1012-5574.152707","Barbary, NE. et al (2014)","Targeted mutation screen/case series"]
["https://www.scopus.com/pages/publications/84981190748?inward","Ben-Rebeh. Et al (2016)","Experimental Design (Screening analysis)"]
["10.3906/biy-1012-174","Biyikli, AT. (2012)","Cross-sectional genetic epidemiology"]
["10.1002/ajmg.a.36068","Yongchuan, C. et al (2013)","Experimental Design (Screening analysis)"]
["10.3889/MJMS.1857-5773.2013.0287","Meguid, N. et al (2013)","Cross-sectional genetic epidemiology"]
["10.4103/0971-7749.94491","Nayyar, SS. Et al (2011)","Cross-sectional genetic epidemiology"]
["10.1371/journal.pone.0021665","Rodriguez-Paris, J. et al (2011)","Allele-specific expression study"]
["10.1002/ajmg.a.36017","Vona, B. et al (2013)","Family based case series"]
["https://www.scopus.com/pages/publications/79551708550?inward","Aparisi, MJ. Et al (2010)","Targeted gene screen"]
["10.2478/v10046-009-0031-8","Sterna, O. et al (2009)","Cross-sectional genetic epidemiology"]
["10.1038/ejhg.2008.30","Pera, A. et al (2008)","Cross-sectional genetic epidemiology"]
["10.1007/s00109-005-0719-4","Kalay, E. et al (2005)","Family based case series"]
["10.1002/ajmg.a.30980","Street, VA. Et al (2005)","Experimental Design (Screening analysis)"]
["10.1016/j.heares.2005.08.001","Gazzaz, B. et al (2005)","Experimental Design (Screening analysis)"]
["10.1038/sj.ejhg.5201491","Hansen, L. et al (2005)","Familial-based case series"]
["10.1080/00016480510044232","Noguchi, Y. et al (2009)","Familial-based case series"]
["10.1111/j.1399-0004.2005.00481.x","Bernal, S. et al (2005)","Cross-sectional genetic epidemiology"]
["10.1016/j.heares.2005.04.012","Dalamo, V. et al (2005)","Cross-sectional genetic epidemiology"]
["10.1016/j.anl.2005.01.011","Asamura, K. et al (2005)","Cross-sectional genetic epidemiology"]
["10.1111/j.1399-0004.2004.00386.x","Park, HJ. et al (2005)","Cross-sectional genetic epidemiology"]
["10.1046/j.1529-8817.2003.00120.x","Seeman, P. et al (2005)","Experimental Design (Screening analysis)"]
["10.1111/j.1399-0004.2004.00334.x","Tekin, M. et al (2004)","Cross-sectional genetic epidemiology"]
["https://mednexus.org/doi/pdf/10.3760/cma.j.issn.0366-6999.2004.12.107","Xiao, Z. Xie, D. (2004)","Cross-sectional genetic survey"]
["10.1111/j.1399-0004.2004.00325.x","Wattanasirichaigoon, D. et al (2004)","Cross-sectional genetic survey"]
["10.1016/j.heares.2004.07.001","Frei, K. et al (2004)","Cross-sectional genetic epidemiology"]
["10.1016/j.heares.2004.05.007","Piatto, VB. et al (2004)","Cross-sectional genetic epidemiology"]
["10.1097/00129492-200409000-00011","Makishima, T. et al (2004)","Familial-based case series"]
["10.1007/s00405-003-0679-7","Iliadou, V. et al (2004)","Cross-sectional genetic epidemiology"]
["10.1038/sj.ejhg.5201138","Aller, E. et al (2004)","Cross-sectional genetic epidemiology"]
["10.1186/s40246-023-00489-1","Asaad, M. et al. (2023)","Experimental Design (Screening analysis)"]
["10.1007/s00439-023-02581-x","Roux, I. et al. (2023)","Experimental Design (Screening analysis)"]
["10.1097/00129492-200501000-00009","Topsakal, V. et al (2005)","Experimental Design (Screening analysis, audiometric analysis)"]
["10.1097/00005537-200404000-00003","Erbe, CB. et al (2009)","Cross-sectional genetic epidemiology"]
["10.1186/1471-2350-5-5","Roux, AF. Et al (2004)","Experimental Design (audiometric analysis)"]
["https://pubmed.ncbi.nlm.nih.gov/15113126/","Minarik, G. et al (2003)","Experimental Design (Screening analysis)"]
["10.1097/00005537-200310000-00018","Lopponen, T. et al (2010)","Cross-sectional genetic epidemiology"]
["10.1001/archotol.129.8.836","Lim, LHY. Et al (2003)","Retrospective Cross-sectional study"]
["10.1034/j.1399-0004.2003.00101.x","Uyguner, O. et al (2003)","Cross-sectional genetic epidemiology"]
["10.1001/archotol.129.4.421","Pennings, RJE. Et al (2003)","Experimental Design (Screening analysis)"]
["10.1016/s0165-5876(02)00177-5","Pampanos, A. et al (2002)","Experimental Design (Screening analysis)"]
["10.1177/0003489415575043","Ichinose (2015)","A genetic screening study with mild to moderate hearing loss"]
["https://doi.org/10.1016/j.jgg.2012.11.002","Zong, L. et al (2012)","Familial-based Case series / Linkage-mapping study"]
["https://doi.org/10.1007/s00405-017-4699-0","Parzefall, T. et al (2017)","Familial-based case series"]
["https://doi.org/10.1016/j.ijporl.2018.01.005","Cheng, H. et al (2018)","familial-based case study"]
["https://doi.org/10.1371/journal.pone.0193359","Kobayashi, M. et al (2018)","Cross-sectional genetic epidemiology"]
["https://doi.org/10.1002/lary.26528","Kasakura-Kimura, N. et al (2017)","Retrospective case series"]
["https://doi.org/10.1016/j.heares.2016.02.009","Jung, J. et al (2016)","Retrospective case series"]
["https://doi.org/10.3109/14017431.2014.988172","Winbo, A. and Rydberg, A. et al (2015)","Retrospective case series/Prospective vestibular testing"]
["https://doi.org/10.1007/s00439-022-02431-2","Usami, S. et al (2022)","Cross-sectional genetic epidemiology"]
["https://doi.org/10.1111/j.1399-0004.2009.01344.x","Hildebrand, M.S. et al (2010)","Familial-based case series/linkage"]
["https://doi.org/10.1016/j.heares.2011.08.010","Weegerink, N.J.D. et al (2011)","Familial-based case series/linkage"]
["https://doi.org/10.1002/ajmg.a.31486","Huculak, C., Rogala, L. and Rogaeva, E. (2006)","Case-control genetic association"]
["https://doi.org/10.1016/j.heares.2014.12.006","Lenarduzzi, S. et al (2015)","Observational diagnostic sequencing study"]
["https://doi.org/10.3389/fgene.2021.780874","Moon, I.S. et al (2021)","Retrospective case series"]
["https://doi.org/10.1002/(sici)1098-1004(200004)15:4%3C388::aid-humu27%3E3.0.co;2-n","Adato, A. et al (2000)","Genetic case series"]
["https://doi.org/10.1097/mao.0000000000003825","Achard, S. et al (2023)","Observational descriptive epidemiological study"]
["https://doi.org/10.1038/ejhg.2013.5","Abdelfatah, N. et al (2013)","Familial-based case series"]
["10.1016/j.jgg.2012.11.002","Zong, L. et al (2012)","Family-based linkage study"]
["https://doi.org/10.1097/aud.0000000000000878","Roman-Naranjo, P. et al (2020)","Case-control genetic association study"]
["https://doi.org/10.1007/s00405-016-3896-6","Acke, F.R. et al (2016)","Obsevational/Cross-sectional audiometric phenotype study"]
["https://doi.org/10.1002/ajmg.a.35572","Babanejad, M. et al (2012)","Familial-based case series"]
["https://doi.org/10.3390/ijms252212169","Ogorodova, N. et al (2024)","Cross-sectional genetic epidemiology"]
["10.1136/jmedgenet-2017-104721","Chattaraj, P. et al. (2017)","Genotype-phenotype association study"]
["https://doi.org/10.1136/jmg.38.8.515","Laer, LV. et al. (2001)","Case-control genetic association study"]
["https://doi.org/10.1007/s00439-021-02405-w","Solovyev, AV. et al. (2022)","Genetic epidemiology"]
["https://doi.org/10.1007/s00438-014-0979-1","Sang, Q. et al. (2015)","Familial-based genetic study"]

{"sheet":"Supplementary Table S6.","index":6,"n_rows":19,"n_cols":23,"rows_kept":19,"merged":[[0,13,0,22]]}
["Supplementary Table S6.- Risk of Bias Assessment for the selected animal (Mus musculus) studies ",{"$nulls":12},"SYRCLE Items"]
[{"$nulls":13},1,"Sequency Generation",3,"Allocation concealmeant",5,"Blinding",7,"Blinding",9,"Selective outcome reporting"]
["DOI","First Author","Item 1","Item 2 ","Item 3 ","Item 4","Item 5","Item 6","Item 7 ","Item 8 ","Item 9 ","Item 10 ",null,2,"Baseline Characteristics",4,"Random Housing",6,"Random outcome assessment",8,"Incomplete outcome data",10,"Other sources of bias"]
["Mus musculus "]
["https://doi.org/10.1016/j.bpj.2021.09.029","Mansour, A. et al. (2021)","Low","Low","Low","Low","Low","Low","Low","Low","Low","Low"]
["https://doi.org/10.1186/s12915-022-01257-8","Lewis, MA. et al. (2022)","High ","Low","Unclear ","Unclear","High ","Unclear","Unclear","Unclear","Unclear","High "]
["https://doi.org/10.1038/s41598-018-29709-8","Nakanishi, H. et al. (2018)","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Unclear "]
["https://doi.org/10.1523/jneurosci.3635-11.2012","Goodyear, RJ. et al. (2012)","Unclear ","Unclear ","High ","Unclear ","High ","Unclear ","High ","Low","Low","Unclear "]
["https://doi.org/10.1007/s10162-011-0270-7","Keller, JM. et al. (2011)","Unclear ","Unclear ","High ","Unclear ","High ","Unclear ","High ","Low","Low","Unclear "]
["https://doi.org/10.3389/fnins.2019.01255","Calabro, KR. et al. (2019)","Unclear ","Low","Unclear ","Unclear ","Moderate","Moderate","Low","Unclear ","Moderate","Low"]
["https://doi.org/10.1016/j.ajhg.2010.01.016","Odeh, H. et al. 2010","Unclear ","Low","Unclear ","Unclear ","Unclear ","Low","Unclear","Unclear","Low","Low"]
["https://doi.org/10.1007/s00335-004-2344-x","Rhodes, CR. et al. (2004)","Unclear ","Low","Unclear ","Unclear ","Unclear ","Low","Unclear","Unclear","Low","Low"]
["https://doi.org/10.1038/nn1828","Russel, IJ. et al. (2007)","Unclear ","Low","Unclear ","Unclear","High ","Low","Unclear","Low","Low","Unclear "]
["https://doi.org/10.1016/j.heares.2011.08.005","Hurd, EA. et al. (2011)","Unclear ","Low","Unclear ","Unclear","Unclear ","Unclear","Low","High","Low","Low"]
["https://doi.org/10.1002/jnr.24905","Zhao, T. et al. (2021)","Low","Low","Unclear ","Low","Low","Low","Low","Low","Low","Low"]
["10.1016/j.heares.2010.11.002","Jones et al., (2010)","Low","Low","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Low","Low","Low"]
["10.1016/j.neuroscience.2009.08.043","Minekawa et al./2009","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Unclear ","Low","Unclear ","Low"]
["10.1093/hmg/ddn311","Mansour et al./2009","Unclear ","Low","Unclear ","Unclear","Low","Low","Unclear","Low","Low","Moderate"]
["10.1093/hmg/ddn236","Robertson et al./2008","Unclear ","Low","Unclear ","Unclear","Low","Low","Unclear","Low","Low","Moderate"]

{"sheet":"Supplementary Table S7.","index":7,"n_rows":9,"n_cols":31,"rows_kept":9,"merged":[[0,21,0,26],[4,21,4,30]]}
["Supplementary Table S7.- Risk of Bias Assessment for the selected human and animal (Mus musculus) studies",{"$nulls":20},"ROBINS-E Domains "]
[{"$nulls":21},"D1","Confounding-induced bias","D3","Bias in participant selection for the study","D6","Bias in outcome measurement"]
["DOI","First Author","Item 1","Item 2 ","Item 3 ","Item 4","Item 5","Item 6","Item 7 ","Item 8 ","Item 9 ","Item 10 ","D1","D2","D3","D4","D5","D6","D7",null,null,"D2","Bias in exposure measurement","D5","Bias due to missing data","D7","Bias in the selection of reported results"]
["https://doi.org/10.1007/s12035-021-02422-w","Fu, X. et al. (2021)","Unclear ","Low","Unclear","Unclear","Unclear","Moderate","Unclear","Moderate","Low","Low"]
["https://doi.org/10.1016/j.ajhg.2018.05.011","Wesdorp, M. et al. (2018)","Low","Low","Unclear","Unclear","Unclear","Unclear","Low","Low","Low","Low",{"$nulls":9},"SYRCLE Items"]
["https://doi.org/10.1111/cge.12915","Neuhaus, C. et al. (2016)","Unclear","Low","Unclear","Unclear","Unclear","Unclear","Low","Low","Low","Low",{"$nulls":9},1,"Sequency Generation",3,"Allocation concealmeant",5,"Blinding",7,"Blinding",9,"Selective outcome reporting"]
["https://doi.org/10.1038/70516","McGuirt, WT. et al. (1999)","Unclear","Unclear","Low","Unclear","Low","Unclear","Unclear","Low","Low","Low",{"$nulls":9},2,"Baseline Characteristics",4,"Random Housing",6,"Random outcome assessment",8,"Incomplete outcome data",10,"Other sources of bias"]
["https://doi.org/10.1007/s00439-018-1901-4","Bademci, G. et al. (2018)","Unclear ","Unclear ","High ","Unclear ","High ","Unclear ","High ","Low","Low","Unclear "]
["https://doi.org/10.1007/s00438-014-0979-1","Sang, Q. et al. (2015)","Unclear ","Low","Unclear","Unclear","High ","Low","Unclear","Low","Low","Moderate"]

{"sheet":"Supplementary Table S8.","index":8,"n_rows":356,"n_cols":3,"rows_kept":356}
["Supplementary Table S8.- Deafness Variation Database (DVD) and International Mouse Phenotyping Consortium (IMPC) Gene Lists "]
[]
["Deafness Variation Database ","International Mouse Phenotyping Consortium","Overlapping Genes Between Databases"]
["ABHD12","AA986860","ADGRV1"]
["ACTB","Aak1","CABP2"]
["ACTG1","Abca12","CHSY1"]
["ADCY1","Acad11","CIB2"]
["ADGRV1","Actl6b","CLPP"]
["AIFM1","Adamts15","CLRN1"]
["ALMS1","Adgrv1","COL9A2"]
["AMMECR1","Adipor1","COL9A3"]
["ANKH","Adrb2","EPS8L2"]
["ATP2B2","Afap1l2","GIPC3"]
["ATP6V0A4","Agap1","GJB3"]
["ATP6V1B1","Ahrr","GRXCR1"]
["ATP6V1B2","Ahsg","HARS2"]
["BCS1L","Akr1c12","HOMER2"]
["BDP1","Aldoc","HOXA2"]
["BSND","Alg10b","HSD17B4"]
["BTD","Ankrd11","KCNE1"]
["CABP2","Ankrd24","MARVELD2"]
["CACNA1D","Aqp9","MIR96"]
["CCDC50","Arhgap21","MPZL2"]
["CD164","Arhgap29","MYO3A"]
["CDC14A","Arv1","MYO6"]
["CDH23","Asic3","NR2F1"]
["CEACAM16","Aspn","OTOA"]
["CEP78","Atad2b","OTOG"]
["CHD7","Atg2b","OTOGL"]
["CHSY1","Atg4b","PJVK"]
["CIB2","Atp2b1","REST"]
["CISD2","Atp8b1","SLC17A8"]
["CLDN9","Avpi1","TPRN"]
["CLIC5","Baiap2l2","TRIOBP"]
["CLPP","Bap1"]
["CLRN1","Bicd1"]
["COCH","Blvrb"]
["COL11A1","Bod1"]
["COL11A2","Brd2"]
["COL2A1","Btbd10"]
["COL4A3","Bzw1"]
["COL4A4","C2cd2l"]
["COL4A5","Cabp2"]
["COL4A6","Camsap3"]
["COL9A1","Cbln3"]
["COL9A2","Ccdc117"]
["COL9A3","Ccdc166"]
["CRYM","Ccdc88c"]
["DCAF17","Ccdc92"]
["DCDC2","Ccn5"]
["DIABLO","Cdc37l1"]
["DIAPH1","Cdca5"]
["DIAPH3","Cep128"]
["DLX5","Cep250"]
["DMXL2","Cep85l"]
["DNMT1","Ces1f"]
["DSPP","Chsy1"]
["EDN3","Cib2"]
["EDNRB","Cib3"]
["ELMOD3","Cidec"]
["EPS8","Cimap1d"]
["EPS8L2","Cimip2b"]
["ERAL1","Ckb"]
["ESPN","Clcn1"]
["ESRRB","Clec16a"]
["EYA1","Clec3a"]
["EYA4","Clpp"]
["FDXR","Clrn1"]
["FGF3","Clrn2"]
["FGFR1","Cntnap5b"]
["FGFR2","Col9a2"]
["FGFR3","Col9a3"]
["FITM2","Csnk1g2"]
["FOXI1","Csnk1g3"]
["GAB1","Cstb"]
["GATA3","Ctf2"]
["GIPC3","Ctu1"]
["GJB2","Cyp17a1"]
["GJB3","D6Wsu163e"]
["GPRASP2","Dbnl"]
["GPSM2","Dctd"]
["GRAP","Defb43"]
["GREB1L","Dennd6b"]
["GRHL2","Depdc1a"]
["GRXCR1","Dhrs1"]
["GRXCR2","Dlec1"]
["GSDME","Dnajb14"]
["HARS2","Dnajc14"]
["HGF","Dnajc16"]
["HOMER2","Dnajc17"]
["HOXA2","Dnase1"]
["HOXB1","Dnmbp"]
["HSD17B4","Dok7"]
["IFNLR1","Dpp4"]
["ILDR1","Dpp8"]
["KARS1","Duoxa2"]
["KCNE1","Dyrk1b"]
["KCNJ10","Dzip1l"]
["KCNQ1 ","Ect2"]
["KCNQ4","Eef1d"]
["KITLG","Efcab7"]
["KMT2D","Efhb"]
["LARS2","Eif1b"]
["LHFPL5","Eif4b"]
["LHX3","Elmo3"]
["LMX1A","Elmod1"]
["LOXHD1","Emsy"]
["LOXL3","Ensa"]
["LRP2","Epn3"]
["LRTOMT","Eps8l2"]
["MAN2B1","Erlec1"]
["MANBA","Espnl"]
["MARVELD2","Fads3"]
["MASP1","Fam120a"]
["MCM2","Fam53b"]
["MET","Fbxl15"]
["MGP","Fbxl8"]
["MIR96","Fbxo24"]
["MITF","Fbxo33"]
["MPZL2","Fbxo41"]
["MSRB3","Fbxo42"]
["MT-CO1","Fbxo48"]
["MT-ND1","Fer"]
["MT-RNR1","Fezf2"]
["MT-TH","Frmd3"]
["MT-TI","Frs2"]
["MT-TK","Fuca1"]
["MT-TL1","Fyb1"]
["MT-TS1","Gabpa"]
["MT-TS2","Gas2l2"]
["MYH14","Gata2"]
["MYH9","Gga1"]
["MYO15A","Ghrhr"]
["MYO3A","Gipc3"]
["MYO6","Gjb3"]
["MYO7A","Gm12258"]
["NARS2","Gm5447"]
["NDP","Golph3"]
["NEFL","Gp6"]
["NF2","Gpr108"]
["NLRP3","Gpr152"]
["NOG","Grxcr1"]
["NR2F1","Gtf2h3"]
["OPA1","Gzf1"]
["OSBPL2","Hars2"]
["OTOA","Haus4"]
["OTOF","Hcn1"]
["OTOG","Herc1"]
["OTOGL","Hhat"]
["P2RX2","Hipk3"]
["PAX1","Hirip3"]
["PAX3","Hmgcs1"]
["PCDH15","Hmx2"]
["PDE1C","Hnf4g"]
["PDZD7","Homer2"]
["PEX1","Hoxa2"]
["PEX26","Hsd17b4"]
["PEX6","Hsfy2"]
["PJVK","Idua"]
["PLS1","Igfbp6"]
["PNTP1","Ikzf2"]
["POLR1B","Il10ra"]
["POLR1C","Il1r2"]
["POLR1D","Il2rb"]
["POU3F4","Iqgap2"]
["POU4F3","Ist1"]
["PPIP5K2","Jakmip2"]
["PRPS1","Kcne1"]
["PTPRQ","Kcnj11"]
["RAI1","Kcnma1"]
["RDX","Kif13a"]
["REST","Kif1b"]
["RIPOR2","Kif5a"]
["ROR1","Klc2"]
["S1PR2","Klhdc7b"]
["SEMA3E","Klhdc8b"]
["SERPINB6","Klk5"]
["SIX1","Klkb1"]
["SIX2","Krit1"]
["SIX5","Krtcap2"]
["SLC17A8","Lcorl"]
["SLC19A2","Ldhal6b"]
["SLC22A4","Ldlr"]
["SLC26A4","Lrba"]
["SLC26A5","Lsm1"]
["SLC33A1","Lsm14a"]
["SLC44A4","Mag"]
["SLC4A11","Map7"]
["SLC52A2","Marveld2"]
["SLC52A3","Maz"]
["SLITRK6","Mcidas"]
["SMPX","Med10"]
["SNAI2","Med25"]
["SOX10","Med28"]
["SPATA5","Mettl5"]
["SPNS2","Mgrn1"]
["STRC","Mical3"]
["SUCLA2","Minar2"]
["SYNE4","Mir96"]
["TBC1D24","Mkrn2"]
["TBL1X","Mllt10"]
["TBX1","Mpdz"]
["TCOF1","Mphosph8"]
["TECTA","Mpzl2"]
["TFAP2A","Mreg"]
["TIMM8A","Mrpl39"]
["TJP2","Msantd3"]
["TMC1","Myh1"]
["TMEM126A","Myo18b"]
["TMEM132E","Myo1d"]
["TMIE","Myo3a"]
["TMPRSS3","Myo6"]
["TNC","Nacc1"]
["TPRN","Ncoa2"]
["TRIOBP","Nedd4l"]
["TRRAP","Nek2"]
["TSPEAR","Nin"]
["TUBB4B","Nipsnap3b"]
["TWNK","Nlk"]
["USH1C","Nptn"]
["USH1G","Nr2f1"]
["USH2A","Nrp1"]
["WBP2","Osbpl8"]
["WFS1","Otoa"]
["WHRN","Otog"]
[null,"Otogl"]
[null,"Oxsm"]
[null,"Pacsin2"]
[null,"Padi3"]
[null,"Pax5"]
[null,"Pcdhb9"]
[null,"Pcnp"]
[null,"Pcnx4"]
[null,"Pcp4l1"]
[null,"Pcyox1l"]
[null,"Phf3"]
[null,"Phf6"]
[null,"Pigq"]
[null,"Pip4k2c"]
[null,"Pjvk"]
[null,"Plag1"]
[null,"Plcb4"]
[null,"Plekhf2"]
[null,"Plin4"]
[null,"Plod3"]
[null,"Plscr5"]
[null,"Ppia"]
[null,"Ppox"]
[null,"Ppp1r14a"]
[null,"Ppp2r5e"]
[null,"Ppp6c"]
[null,"Pramel17"]
[null,"Prdm5"]
[null,"Prkra"]
[null,"Prmt9"]
[null,"Prrc2c"]
[null,"Prss36"]
[null,"Ptafr"]
[null,"Ptchd1"]
[null,"Ptgs1"]
[null,"Pycr3"]
[null,"Rab10"]
[null,"Rab11fip3"]
[null,"Rab39b"]
[null,"Rap1gap2"]
[null,"Rcor3"]
[null,"Reg2"]
[null,"Relch"]
[null,"Rell1"]
[null,"Rest"]
[null,"Rfxap"]
[null,"Rnf10"]
[null,"Rnf123"]
[null,"Rpain"]
[null,"Rrbp1"]
[null,"Rtn4"]
[null,"Rtn4rl2"]
[null,"S100a1"]
[null,"Satb1"]
[null,"Scamp2"]
[null,"Scrn1"]
[null,"Secisbp2l"]
[null,"Selenok"]
[null,"Serinc3"]
[null,"Serpina3i"]
[null,"Serpinb9c"]
[null,"Serpine3"]
[null,"Setd5"]
[null,"Slc17a8"]
[null,"Slc20a2"]
[null,"Slc25a1"]
[null,"Slc4a10"]
[null,"Slc5a5"]
[null,"Slc7a11"]
[null,"Slx9"]
[null,"Smarcc2"]
[null,"Smim22"]
[null,"Snx29"]
[null,"Srd5a3"]
[null,"Stim2"]
[null,"Stk38"]
[null,"Stradb"]
[null,"Sun1"]
[null,"Syncrip"]
[null,"Tbl1xr1"]
[null,"Tbx20"]
[null,"Tesk2"]
[null,"Thoc3"]
[null,"Tle4"]
[null,"Tmco6"]
[null,"Tmem108"]
[null,"Tmem131l"]
[null,"Tmem145"]
[null,"Tmem30b"]
[null,"Tmem51"]
[null,"Tmprss2"]
[null,"Tmtc4"]
[null,"Tnfrsf11b"]
[null,"Tomt"]
[null,"Topors"]
[null,"Tox"]
[null,"Tprn"]
[null,"Trappc11"]
[null,"Trim10"]
[null,"Trim35"]
[null,"Trim37"]
[null,"Trim39"]
[null,"Trim69"]
[null,"Triobp"]
[null,"Ttbk1"]
[null,"Tti1"]
[null,"U2af1"]
[null,"U2af2"]
[null,"Ube2g1"]
[null,"Ube2w"]
[null,"Uqcc3"]
[null,"Usp30"]
[null,"Usp39"]
[null,"Usp43"]
[null,"Usp53"]
[null,"Vti1a"]
[null,"Wdfy1"]
[null,"Wdr45"]
[null,"Ypel3"]
[null,"Zbtb16"]
[null,"Zc3h7a"]
[null,"Zdhhc11"]
[null,"Zdhhc5"]
[null,"Zfp385c"]
[null,"Zfp438"]
[null,"Zfp445"]
[null,"Zfp469"]
[null,"Zfp652"]
[null,"Zfp719"]
[null,"Zfp74"]
[null,"Zmat4"]

{"sheet":"Supplementary Table S9.","index":9,"n_rows":334,"n_cols":3,"rows_kept":334}
["Supplementary Table S9.- Auditory, Vestibular and Audiovestibular Phenotype Genes According to IMPC "]
[]
["Auditory Phenotype","Vestibular Phenotype","Overlapping Genes (A + V)"]
["Lsm1","Gabpa","Cib2"]
["Map7","Slc25a1","Col9a2"]
["Hnf4g","Kcnma1","Elmod1"]
["Baiap2l2","Col9a2","Grxcr1"]
["Nipsnap3b","Zfp385c","Klhdc7b"]
["Bicd1","Elmod1","Marveld2"]
["Atp8b1","Kcnj11","Mgrn1"]
["Slc17a8","Marveld2","Nptn"]
["Nin","Nptn"]
["Pcdhb9","Cib2"]
["Smarcc2","Grxcr1"]
["Nptn","Prkra"]
["Rab11fip3","Eps8l2"]
["Gipc3","Ikzf2"]
["Cep85l","Klhdc7b"]
["Fbxo42","Mpzl2"]
["Lcorl","Mgrn1"]
["Fbxo48","Cib3"]
["Tmco6","Il2rb"]
["Mir96","Hhat"]
["Duoxa2","Krit1"]
["Mcidas","Kif1b"]
["Tmtc4","Abca12"]
["Relch","Pcnp"]
["Ppia","Tbx20"]
["Plag1","Uqcc3"]
["Zfp74","Pigq"]
["Tmem51","Emsy"]
["Dnajc17","Alg10b"]
["Myh1","Lrba"]
["Plod3"]
["Tprn"]
["Espnl"]
["Mical3"]
["Ppp2r5e"]
["Prdm5"]
["Gata2"]
["Myo6"]
["Rtn4"]
["Arhgap21"]
["Satb1"]
["Slc7a11"]
["Cdca5"]
["Cimap1d"]
["Trim35"]
["Homer2"]
["Wdfy1"]
["Eif4b"]
["Osbpl8"]
["Med10"]
["Col9a3"]
["Eif1b"]
["Col9a2"]
["Myo3a"]
["Pcyox1l"]
["Tesk2"]
["Mettl5"]
["Reg2"]
["Ptafr"]
["Hars2"]
["Ankrd11"]
["Mpdz"]
["Fads3"]
["Golph3"]
["Tmem30b"]
["Rcor3"]
["Ube2w"]
["Rnf123"]
["Ppp6c"]
["Idua"]
["Maz"]
["Plekhf2"]
["Nr2f1"]
["Hsfy2"]
["Nrp1"]
["Ccdc166"]
["Usp30"]
["Elmod1"]
["Tnfrsf11b"]
["Dnajb14"]
["Gzf1"]
["Agap1"]
["Zfp469"]
["Dennd6b"]
["Serpinb9c"]
["Kcne1"]
["Kif13a"]
["Plin4"]
["Fezf2"]
["Rab10"]
["Slc4a10"]
["Csnk1g2"]
["Hsd17b4"]
["Ptgs1"]
["Rpain"]
["Dzip1l"]
["Otoa"]
["Marveld2"]
["Frs2"]
["Msantd3"]
["Nedd4l"]
["Fbxl8"]
["Ncoa2"]
["Serinc3"]
["Defb43"]
["Ctf2"]
["Mphosph8"]
["Scamp2"]
["Selenok"]
["Mgrn1"]
["Cntnap5b"]
["Eef1d"]
["Rtn4rl2"]
["Zmat4"]
["Sun1"]
["Setd5"]
["Zfp719"]
["Tmem145"]
["Mreg"]
["Gp6"]
["Prss36"]
["Klhdc7b"]
["Dpp8"]
["Trim10"]
["Adgrv1"]
["Slc5a5"]
["Pjvk"]
["Zbtb16"]
["Usp53"]
["Prmt9"]
["Padi3"]
["Tox"]
["Ahrr"]
["U2af1"]
["Clrn2"]
["Stk38"]
["Trim37"]
["Otog"]
["Cep250"]
["Zfp652"]
["Acad11"]
["Gtf2h3"]
["C2cd2l"]
["Ckb"]
["Clpp"]
["Adipor1"]
["Chsy1"]
["Camsap3"]
["Bzw1"]
["Ppox"]
["Dhrs1"]
["Trim39"]
["Rest"]
["Minar2"]
["Tmem108"]
["Topors"]
["Herc1"]
["Dnase1"]
["Grxcr1"]
["Fbxl15"]
["Myo18b"]
["Arv1"]
["Gpr108"]
["Ccdc88c"]
["Fyb1"]
["Snx29"]
["Clrn1"]
["Ces1f"]
["Cabp2"]
["Stradb"]
["Trim69"]
["Pax5"]
["Ube2g1"]
["Plscr5"]
["Dok7"]
["Akr1c12"]
["Atg2b"]
["Srd5a3"]
["Ypel3"]
["Dyrk1b"]
["Tbl1xr1"]
["Blvrb"]
["Hoxa2"]
["Afap1l2"]
["Mag"]
["Erlec1"]
["Ttbk1"]
["Rell1"]
["Dctd"]
["Tmprss2"]
["Fam120a"]
["Jakmip2"]
["Cbln3"]
["Slx9"]
["D6Wsu163e"]
["Il10ra"]
["Iqgap2"]
["Gm5447"]
["Adamts15"]
["AA986860"]
["Rap1gap2"]
["Aak1"]
["Ptchd1"]
["Dnajc16"]
["Btbd10"]
["Aldoc"]
["Klkb1"]
["Pacsin2"]
["Klc2"]
["Frmd3"]
["Cib2"]
["Pcnx4"]
["Krtcap2"]
["Rfxap"]
["Smim22"]
["Hirip3"]
["Cdc37l1"]
["Actl6b"]
["Fuca1"]
["Hipk3"]
["Stim2"]
["Zdhhc11"]
["Tomt"]
["S100a1"]
["Pycr3"]
["Secisbp2l"]
["Ldlr"]
["Ahsg"]
["Epn3"]
["Ldhal6b"]
["Dnmbp"]
["Scrn1"]
["Ccdc117"]
["Ensa"]
["Efhb"]
["Dnajc14"]
["Ccdc92"]
["Pcp4l1"]
["Lsm14a"]
["Fbxo41"]
["Ccn5"]
["Mrpl39"]
["Serpine3"]
["Mkrn2"]
["Ppp1r14a"]
["Nek2"]
["Avpi1"]
["Tti1"]
["Clec3a"]
["Phf6"]
["Dpp4"]
["Zc3h7a"]
["Tmem131l"]
["Cyp17a1"]
["Dbnl"]
["Prrc2c"]
["Rrbp1"]
["Nacc1"]
["Ist1"]
["Depdc1a"]
["Bod1"]
["Fbxo33"]
["Otogl"]
["Oxsm"]
["Zfp438"]
["Bap1"]
["Clcn1"]
["U2af2"]
["Asic3"]
["Nlk"]
["Dlec1"]
["Triobp"]
["Gjb3"]
["Adrb2"]
["Mllt10"]
["Cep128"]
["Wdr45"]
["Igfbp6"]
["Ghrhr"]
["Haus4"]
["Arhgap29"]
["Ankrd24"]
["Zdhhc5"]
["Zfp445"]
["Gm12258"]
["Atg4b"]
["Cidec"]
["Csnk1g3"]
["Vti1a"]
["Aspn"]
["Rnf10"]
["Aqp9"]
["Plcb4"]
["Myo1d"]
["Hmx2"]
["Klhdc8b"]
["Il1r2"]
["Usp43"]
["Trappc11"]
["Slc20a2"]
["Serpina3i"]
["Fbxo24"]
["Klk5"]
["Gas2l2"]
["Fam53b"]
["Pip4k2c"]
["Thoc3"]
["Med25"]
["Elmo3"]
["Fer"]
["Gpr152"]
["Cstb"]
["Pramel17"]
["Kif5a"]
["Ect2"]
["Tle4"]
["Rab39b"]
["Clec16a"]
["Med28"]
["Atad2b"]
["Hmgcs1"]
["Cimip2b"]
["Hcn1"]
["Phf3"]
["Gga1"]
["Ctu1"]
["Syncrip"]
["Efcab7"]
["Atp2b1"]
["Brd2"]
["Usp39"]

{"sheet":"Supplementary Table S10. ","index":10,"n_rows":104,"n_cols":79,"rows_kept":104,"merged":[[2,0,2,9],[2,10,2,19],[2,20,2,29],[2,30,2,39],[2,40,2,49],[2,50,2,59],[2,60,2,69],[2,70,2,80]]}
["Supplementary Table S10. - Gene Homology Analysis Using BLAST Tool for CIB2, COL9A2, ELMOD1,GRXCR1, KLHDC7B, MARVELD2, MGRN1, NPTN"]
[]
["CIB2 - Cib2",{"$nulls":9},"COL9A2 - Col9a2",{"$nulls":9},"ELMOD1 - Elmod1",{"$nulls":9},"GRXCR1 - Grxcr1",{"$nulls":9},"KLHDC7B - Klhdc7b",{"$nulls":9},"MARVELD2 - Marveld2",{"$nulls":9},"MGRN1 - Mgrn1",{"$nulls":9},"NPTN - Nptn"]
["Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  ",null,"Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  ",null,"Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  ",null,"Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  ",null,"Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  ",null,"Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  ",null,"Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  ",null,"Description","Scientific Name","Max Score","Total Score","Query Cover","E value","Per. ident","Acc. Len","Accession  "]
["Mus musculus musculus strain C57BL/10 chromosome 15 sequence","Mus musculus musculus",49731,{"v":415600,"d":"4.16E+05"},{"v":1,"d":"100%"},0,100,2566542,"OK040660.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",436,{"v":332800,"d":"3.33E+05"},{"v":0.08,"d":"8%"},{"v":3e-118,"d":"3.00E-118"},92.06,4855227,"OK040670.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",549,{"v":3009000,"d":"3.01E+06"},{"v":0.12,"d":"12%"},{"v":2e-151,"d":"2.00E-151"},87.95,16711841,"OK040661.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",2808,{"v":2791000,"d":"2.79E+06"},{"v":0.11,"d":"11%"},0,97.91,16711841,"OK040661.1",null,"Mus musculus kelch domain containing 7B (Klhdc7b), mRNA","Mus musculus",987,1091,{"v":0.29,"d":"29%"},0,80.06,5764,"NM_001160178.2",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",1616,{"v":2820000,"d":"2.82E+06"},{"v":0.37,"d":"37%"},0,93.63,15712434,"OK040665.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",915,{"v":2625000,"d":"2.63E+06"},{"v":0.26,"d":"26%"},0,85.21,4352563,"OK040673.1",null,"Mus musculus BAC clone RP23-117L24 from chromosome 9, complete sequence","Mus musculus",2076,9787,{"v":0.15,"d":"15%"},0,85.67,222698,"AC140054.5"]
["Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",462,{"v":2468000,"d":"2.47E+06"},{"v":0.14,"d":"14%"},{"v":8e-126,"d":"8.00E-126"},80.67,15712434,"OK040665.1",null,"Mus musculus musculus strain C57BL/10 chromosome 1 sequence","Mus musculus musculus",427,{"v":298100,"d":"2.98E+05"},{"v":0.08,"d":"8%"},{"v":2e-115,"d":"2.00E-115"},93.43,1899750,"OK040659.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",545,{"v":2273000,"d":"2.27E+06"},{"v":0.17,"d":"17%"},{"v":2E-150,"d":"2.00E-150"},87.85,4855227,"OK040670.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",2806,{"v":1466000,"d":"1.47E+06"},{"v":0.14,"d":"14%"},0,97.56,9609886,"OK040671.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Tymp:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",987,1091,{"v":0.29,"d":"29%"},0,80.06,39946,"JN950069.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",1410,{"v":999900,"d":"1.00E+06"},{"v":0.44,"d":"44%"},0,90.2,3752979,"OK040666.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",915,{"v":2625000,"d":"2.63E+06"},{"v":0.26,"d":"26%"},0,85.21,4352532,"OK040663.1",null,"Mouse DNA sequence from clone RP24-78F21 on chromosome 9, complete sequence","Mus musculus",2076,9787,{"v":0.15,"d":"15%"},0,85.67,225365,"CT030640.9"]
["Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",459,{"v":1179000,"d":"1.18E+06"},{"v":0.18,"d":"18%"},{"v":1e-124,"d":"1.00E-124"},80.57,4352563,"OK040673.1",null,"Mus musculus musculus strain O20 chromosome 1 sequence","Mus musculus musculus",427,{"v":298100,"d":"2.98E+05"},{"v":0.08,"d":"8%"},{"v":2e-115,"d":"2.00E-115"},93.43,1899751,"OK040667.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",545,{"v":2992000,"d":"2.99E+06"},{"v":0.12,"d":"12%"},{"v":2E-150,"d":"2.00E-150"},87.32,15712434,"OK040665.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",2798,{"v":1545000,"d":"1.55E+06"},{"v":0.12,"d":"12%"},0,97.5,4352563,"OK040673.1",null,"Mus musculus chromosome 15, clone RP23-146F23, complete sequence","Mus musculus",987,1091,{"v":0.29,"d":"29%"},0,80.06,184010,"AC113976.13",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",1386,{"v":2207000,"d":"2.21E+06"},{"v":0.39,"d":"39%"},0,89.63,9609886,"OK040671.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",898,{"v":3251000,"d":"3.25E+06"},{"v":0.21,"d":"21%"},0,84.74,15712434,"OK040665.1",null,"Mus musculus BAC clone RP24-144C11 from chromosome 9, complete sequence","Mus musculus",2076,8688,{"v":0.13,"d":"13%"},0,85.67,177653,"AC159102.2"]
["Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",459,{"v":1179000,"d":"1.18E+06"},{"v":0.18,"d":"18%"},{"v":1e-124,"d":"1.00E-124"},80.57,4352532,"OK040663.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",418,{"v":2167000,"d":"2.17E+06"},{"v":0.09,"d":"9%"},{"v":1e-112,"d":"1.00E-112"},91.5,15712434,"OK040665.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",518,{"v":2383000,"d":"2.38E+06"},{"v":0.17,"d":"17%"},{"v":4e-142,"d":"4.00E-142"},87.01,5060266,"OK040664.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",2798,{"v":1545000,"d":"1.55E+06"},{"v":0.12,"d":"12%"},0,97.5,4352532,"OK040663.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Tymp:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",987,1091,{"v":0.29,"d":"29%"},0,80.06,39899,"JN964347.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",1363,{"v":2807000,"d":"2.81E+06"},{"v":0.35,"d":"35%"},0,90.13,16711841,"OK040661.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",869,{"v":2421000,"d":"2.42E+06"},{"v":0.24,"d":"24%"},0,84.15,5060266,"OK040664.1",null,"Mus musculus targeted deletion, lacZ-tagged mutant allele 2410076I21Rik:tm1(KOMP)Wtsi; transgenic","Mus musculus",1373,3615,{"v":0.05,"d":"5%"},0,87.85,37222,"JN961940.1"]
["Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",440,{"v":2484000,"d":"2.48E+06"},{"v":0.14,"d":"14%"},{"v":4e-119,"d":"4.00E-119"},79.81,16711841,"OK040661.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",416,{"v":2153000,"d":"2.15E+06"},{"v":0.09,"d":"9%"},{"v":4e-112,"d":"4.00E-112"},91.48,16711841,"OK040661.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",518,{"v":2487000,"d":"2.49E+06"},{"v":0.17,"d":"17%"},{"v":4e-142,"d":"4.00E-142"},87.01,5060235,"OK040674.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",2796,{"v":1305000,"d":"1.31E+06"},{"v":0.13,"d":"13%"},0,97.78,5060266,"OK040664.1",null,"Mus musculus BAC clone RP24-460O22 from 15, complete sequence","Mus musculus",987,1091,{"v":0.29,"d":"29%"},0,80.06,179386,"AC137513.3",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",1301,{"v":2350000,"d":"2.35E+06"},{"v":0.39,"d":"39%"},0,88.83,4352563,"OK040673.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",869,{"v":2524000,"d":"2.52E+06"},{"v":0.24,"d":"24%"},0,84.15,5060235,"OK040674.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Nptn:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",1373,4842,{"v":0.07,"d":"7%"},0,87.85,40925,"JN959621.1"]
["Mus musculus musculus strain C57BL/10 chromosome 1 sequence","Mus musculus musculus",436,{"v":590800,"d":"5.91E+05"},{"v":0.19,"d":"19%"},{"v":5e-118,"d":"5.00E-118"},79.6,1899750,"OK040659.1",null,"Mus musculus musculus strain C57BL/10 chromosome 15 sequence","Mus musculus musculus",409,{"v":199800,"d":"2.00E+05"},{"v":0.08,"d":"8%"},{"v":6e-110,"d":"6.00E-110"},90.88,2566542,"OK040660.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",514,{"v":2561000,"d":"2.56E+06"},{"v":0.15,"d":"15%"},{"v":6e-141,"d":"6.00E-141"},86.78,4352563,"OK040673.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",2796,{"v":1305000,"d":"1.31E+06"},{"v":0.13,"d":"13%"},0,97.78,5060235,"OK040674.1",null,"Mus musculus targeted deletion, lacZ-tagged mutant allele Odf3b:tm1(KOMP)Wtsi; transgenic","Mus musculus",987,1091,{"v":0.29,"d":"29%"},0,80.06,37222,"JN957851.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",1301,{"v":2350000,"d":"2.35E+06"},{"v":0.39,"d":"39%"},0,88.83,4352532,"OK040663.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",832,{"v":3172000,"d":"3.17E+06"},{"v":0.22,"d":"22%"},0,79.83,16711841,"OK040661.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Nptn:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",1373,4837,{"v":0.07,"d":"7%"},0,87.85,40995,"JN949106.1"]
["Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",436,{"v":354300,"d":"3.54E+05"},{"v":0.18,"d":"18%"},{"v":5e-118,"d":"5.00E-118"},93.81,3752979,"OK040666.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",399,{"v":470800,"d":"4.71E+05"},{"v":0.08,"d":"8%"},{"v":4E-107,"d":"4.00E-107"},90.49,9609886,"OK040671.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",514,{"v":2561000,"d":"2.56E+06"},{"v":0.15,"d":"15%"},{"v":6e-141,"d":"6.00E-141"},86.78,4352532,"OK040663.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",2776,{"v":882600,"d":"8.83E+05"},{"v":0.11,"d":"11%"},0,97.54,4855227,"OK040670.1",{"$nulls":11},"Mus musculus musculus strain C57BL/10 chromosome 15 sequence","Mus musculus musculus",1279,{"v":1092000,"d":"1.09E+06"},{"v":0.45,"d":"45%"},0,88.54,2566542,"OK040660.1",null,"Mus musculus musculus strain C57BL/10 chromosome 1 sequence","Mus musculus musculus",782,{"v":2262000,"d":"2.26E+06"},{"v":0.27,"d":"27%"},0,82.69,1899750,"OK040659.1",null,"Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4932441D17 product:SDR1 PROTEIN homolog [Mus musculus], full insert sequence","Mus musculus",1373,2146,{"v":0.02,"d":"2%"},0,87.85,4533,"AK030091.1"]
["Mus musculus musculus strain O20 chromosome 1 sequence","Mus musculus musculus",436,{"v":590800,"d":"5.91E+05"},{"v":0.19,"d":"19%"},{"v":5e-118,"d":"5.00E-118"},79.6,1899751,"OK040667.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",394,{"v":622000,"d":"6.22E+05"},{"v":0.08,"d":"8%"},{"v":2e-105,"d":"2.00E-105"},91.1,4352563,"OK040673.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",512,{"v":2447000,"d":"2.45E+06"},{"v":0.16,"d":"16%"},{"v":2E-140,"d":"2.00E-140"},97.34,9609886,"OK040671.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",2776,{"v":584500,"d":"5.85E+05"},{"v":0.13,"d":"13%"},0,97.54,3752979,"OK040666.1",{"$nulls":11},"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",1251,{"v":2152000,"d":"2.15E+06"},{"v":0.4,"d":"40%"},0,88.1,5060266,"OK040664.1",null,"Mus musculus musculus strain O20 chromosome 1 sequence","Mus musculus musculus",782,{"v":2262000,"d":"2.26E+06"},{"v":0.27,"d":"27%"},0,82.69,1899751,"OK040667.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X2, mRNA","Mus musculus",1284,2982,{"v":0.03,"d":"3%"},0,89.22,2462,"XM_006510883.3"]
["Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",427,{"v":657300,"d":"6.57E+05"},{"v":0.19,"d":"19%"},{"v":3e-115,"d":"3.00E-115"},92.91,4855227,"OK040670.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",394,{"v":622000,"d":"6.22E+05"},{"v":0.08,"d":"8%"},{"v":2e-105,"d":"2.00E-105"},91.1,4352532,"OK040663.1",null,"Mus musculus MOB1, Mps One Binder kinase activator-like 3 (yeast), mRNA (cDNA clone MGC:68122 IMAGE:4980300), complete cds","Mus musculus",508,508,{"v":0.01,"d":"1%"},{"v":3e-139,"d":"3.00E-139"},87.44,1981,"BC058168.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",2769,{"v":2709000,"d":"2.71E+06"},{"v":0.09,"d":"9%"},0,97.42,15712434,"OK040665.1",{"$nulls":11},"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",1251,{"v":2242000,"d":"2.24E+06"},{"v":0.41,"d":"41%"},0,88.1,5060235,"OK040674.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",719,{"v":2237000,"d":"2.24E+06"},{"v":0.26,"d":"26%"},0,88.27,4855227,"OK040670.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X7, misc_RNA","Mus musculus",1284,2617,{"v":0.03,"d":"3%"},0,89.22,2344,"XR_004935353.1"]
["Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",425,{"v":894200,"d":"8.94E+05"},{"v":0.18,"d":"18%"},{"v":1e-114,"d":"1.00E-114"},93.4,9609886,"OK040671.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",392,{"v":493500,"d":"4.94E+05"},{"v":0.08,"d":"8%"},{"v":6e-105,"d":"6.00E-105"},89.84,5060266,"OK040664.1",null,"Mus musculus MOB1, Mps One Binder kinase activator-like 3 (yeast), mRNA (cDNA clone MGC:47908 IMAGE:1512578), complete cds","Mus musculus",508,508,{"v":0.01,"d":"1%"},{"v":3e-139,"d":"3.00E-139"},87.44,976,"BC037499.1",null,"Mus musculus musculus strain C57BL/10 chromosome 15 sequence","Mus musculus musculus",2767,{"v":520600,"d":"5.21E+05"},{"v":0.12,"d":"12%"},0,97.53,2566542,"OK040660.1",{"$nulls":11},"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",1232,{"v":119300,"d":"1.19E+05"},{"v":0.33,"d":"33%"},0,87.74,596397,"OK040662.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",645,{"v":2483000,"d":"2.48E+06"},{"v":0.23,"d":"23%"},{"v":2E-180,"d":"2.00E-180"},80,9609886,"OK040671.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X12, misc_RNA","Mus musculus",1284,1983,{"v":0.02,"d":"2%"},0,89.22,1996,"XR_004935354.1"]
["Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",416,{"v":943800,"d":"9.44E+05"},{"v":0.18,"d":"18%"},{"v":6e-112,"d":"6.00E-112"},92.2,5060266,"OK040664.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",392,{"v":493500,"d":"4.94E+05"},{"v":0.08,"d":"8%"},{"v":6e-105,"d":"6.00E-105"},89.84,5060235,"OK040674.1",null,"Mus musculus MOB1, Mps One Binder kinase activator-like 3 (yeast), mRNA (cDNA clone IMAGE:6833894)","Mus musculus",508,508,{"v":0.01,"d":"1%"},{"v":3e-139,"d":"3.00E-139"},87.44,2790,"BC052475.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",2710,{"v":107200,"d":"1.07E+05"},{"v":0.08,"d":"8%"},0,96.42,596397,"OK040662.1",{"$nulls":11},"Mus musculus BAC clone RP23-234N1 from chromosome 13, complete sequence","Mus musculus",1134,1510,{"v":0.05,"d":"5%"},0,83.94,215158,"AC165159.2",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",612,{"v":1536000,"d":"1.54E+06"},{"v":0.28,"d":"28%"},{"v":2E-170,"d":"2.00E-170"},85.09,3752979,"OK040666.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X10, mRNA","Mus musculus",1284,2348,{"v":0.02,"d":"2%"},0,89.22,2100,"XM_030244148.2"]
["Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",416,{"v":943800,"d":"9.44E+05"},{"v":0.18,"d":"18%"},{"v":6e-112,"d":"6.00E-112"},92.2,5060235,"OK040674.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",392,{"v":181800,"d":"1.82E+05"},{"v":0.08,"d":"8%"},{"v":6e-105,"d":"6.00E-105"},90.29,3752979,"OK040666.1",null,"Mus musculus MOB family member 4, phocein (Mob4), transcript variant 1, mRNA","Mus musculus",508,508,{"v":0.01,"d":"1%"},{"v":3e-139,"d":"3.00E-139"},87.44,2845,"NM_025283.3",null,"Mus musculus musculus strain C57BL/10 chromosome 1 sequence","Mus musculus musculus",2545,{"v":727100,"d":"7.27E+05"},{"v":0.06,"d":"6%"},0,95.06,1899750,"OK040659.1",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Marveld2:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",1134,1510,{"v":0.05,"d":"5%"},0,83.9,39000,"JN947835.1",null,"Mus musculus musculus strain C57BL/10 chromosome 15 sequence","Mus musculus musculus",584,{"v":1645000,"d":"1.65E+06"},{"v":0.28,"d":"28%"},{"v":4e-162,"d":"4.00E-162"},84.25,2566542,"OK040660.1",null,"Mus musculus, clone IMAGE:4011135, mRNA","Mus musculus",1280,2333,{"v":0.02,"d":"2%"},0,89.4,1957,"BC039191.1"]
["Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",374,63520,{"v":0.15,"d":"15%"},{"v":4e-99,"d":"4.00E-99"},77.97,596397,"OK040662.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",316,31609,{"v":0.08,"d":"8%"},{"v":4e-82,"d":"4.00E-82"},86.18,596397,"OK040662.1",null,"Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130016J02 product:thyroid hormone receptor associated protein 5, full insert sequence","Mus musculus",508,508,{"v":0.01,"d":"1%"},{"v":3e-139,"d":"3.00E-139"},87.44,2000,"AK162327.1",null,"Mus musculus musculus strain O20 chromosome 1 sequence","Mus musculus musculus",2545,{"v":727100,"d":"7.27E+05"},{"v":0.06,"d":"6%"},0,95.06,1899751,"OK040667.1",{"$nulls":11},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Marveld2:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",1134,1510,{"v":0.05,"d":"5%"},0,83.9,39011,"JN951803.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",531,{"v":124800,"d":"1.25E+05"},{"v":0.2,"d":"20%"},{"v":5e-146,"d":"5.00E-146"},82.9,596397,"OK040662.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X3, misc_RNA","Mus musculus",1271,3233,{"v":0.03,"d":"3%"},0,89.22,2630,"XR_003947819.2"]
["Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005C04 product:unclassifiable, full insert sequence","Mus musculus",348,1565,{"v":0.05,"d":"5%"},{"v":2E-91,"d":"2.00E-91"},89.08,2680,"AK169942.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530108P09 product:unclassifiable, full insert sequence","Mus musculus",292,292,{"v":0.01,"d":"1%"},{"v":7e-75,"d":"7.00E-75"},91.51,3590,"AK165488.1",null,"Mus musculus musculus strain C57BL/10 chromosome 15 sequence","Mus musculus musculus",508,{"v":1564000,"d":"1.56E+06"},{"v":0.19,"d":"19%"},{"v":3e-139,"d":"3.00E-139"},97.02,2566542,"OK040660.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530008A19 product:hypothetical protein, full insert sequence","Mus musculus",859,2882,{"v":0.02,"d":"2%"},0,91.3,4959,"AK149653.1",{"$nulls":11},"Mus musculus MARVEL (membrane-associating) domain containing 2 (Marveld2), transcript variant 1, mRNA","Mus musculus",1098,1458,{"v":0.05,"d":"5%"},0,83.76,3061,"NM_001038602.4",null,"Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030463G20 product:unclassifiable, full insert sequence","Mus musculus",518,4049,{"v":0.06,"d":"6%"},{"v":4e-142,"d":"4.00E-142"},83.84,1883,"AK078768.1",null,"Mus musculus neuroplastin (Nptn), transcript variant 3, mRNA","Mus musculus",1271,2969,{"v":0.03,"d":"3%"},0,89.22,2390,"NM_001357751.2"]
["Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208N06 product:hypothetical protein, full insert sequence","Mus musculus",322,2662,{"v":0.09,"d":"9%"},{"v":1E-83,"d":"1.00E-83"},78.27,2137,"AK155211.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208N06 product:hypothetical protein, full insert sequence","Mus musculus",281,996,{"v":0.05,"d":"5%"},{"v":1e-71,"d":"1.00E-71"},84.12,2137,"AK155211.1",null,"Mus musculus melanocyte cDNA, RIKEN full-length enriched library, clone:G270069M09 product:preimplantation protein 3, full insert sequence","Mus musculus",508,508,{"v":0.01,"d":"1%"},{"v":3e-139,"d":"3.00E-139"},87.44,2786,"AK147857.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630221F08 product:unclassifiable, full insert sequence","Mus musculus",859,2882,{"v":0.02,"d":"2%"},0,91.3,6620,"AK171052.1",{"$nulls":11},"Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730403P06 product:MARVEL (membrane-associating) domain containing 2, full insert sequence","Mus musculus",1098,1458,{"v":0.05,"d":"5%"},0,83.76,3037,"AK133741.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208N06 product:hypothetical protein, full insert sequence","Mus musculus",424,5313,{"v":0.09,"d":"9%"},{"v":9e-114,"d":"9.00E-114"},81.26,2137,"AK155211.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X11, misc_RNA","Mus musculus",1271,2598,{"v":0.03,"d":"3%"},0,89.22,2268,"XR_003947820.2"]
["Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530108P09 product:unclassifiable, full insert sequence","Mus musculus",283,1152,{"v":0.04,"d":"4%"},{"v":6e-72,"d":"6.00E-72"},89.04,3590,"AK165488.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",272,4254,{"v":0.05,"d":"5%"},{"v":9e-69,"d":"9.00E-69"},83.39,70497,"ON637244.1",null,"Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430030N12 product:preimplantation protein 3, full insert sequence","Mus musculus",503,503,{"v":0.01,"d":"1%"},{"v":1e-137,"d":"1.00E-137"},87.22,1139,"AK020446.1",null,"Mus musculus chromosome 5, clone RP23-387L12, complete sequence","Mus musculus",640,1096,{"v":0.01,"d":"1%"},{"v":2e-178,"d":"2.00E-178"},79.91,196977,"AC160555.4",{"$nulls":11},"PREDICTED: Mus musculus MARVEL (membrane-associating) domain containing 2 (Marveld2), transcript variant X1, mRNA","Mus musculus",1094,1454,{"v":0.05,"d":"5%"},0,83.73,3376,"XM_006517605.2",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005C04 product:unclassifiable, full insert sequence","Mus musculus",379,7332,{"v":0.09,"d":"9%"},{"v":2E-100,"d":"2.00E-100"},90.17,2680,"AK169942.1",null,"Mus musculus neuroplastin (Nptn), transcript variant 1, mRNA","Mus musculus",1271,2335,{"v":0.02,"d":"2%"},0,89.22,2054,"NM_009145.3"]
["Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",281,9759,{"v":0.05,"d":"5%"},{"v":2e-71,"d":"2.00E-71"},84.54,70497,"ON637244.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014J03 product:unclassifiable, full insert sequence","Mus musculus",272,760,{"v":0.05,"d":"5%"},{"v":9e-69,"d":"9.00E-69"},84.08,1592,"AK156276.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",501,{"v":1478000,"d":"1.48E+06"},{"v":0.2,"d":"20%"},{"v":5E-137,"d":"5.00E-137"},96.69,3752979,"OK040666.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530025L07 product:unclassifiable, full insert sequence","Mus musculus",508,1115,{"v":0.01,"d":"1%"},{"v":5e-139,"d":"5.00E-139"},83.66,2026,"AK149887.1",{"$nulls":11},"Mus musculus tricellulin isoform a (Tric) mRNA, complete cds","Mus musculus",1088,1449,{"v":0.05,"d":"5%"},0,83.65,1888,"DQ143929.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530101D17 product:unclassifiable, full insert sequence","Mus musculus",372,4481,{"v":0.06,"d":"6%"},{"v":3E-98,"d":"3.00E-98"},88.5,3223,"AK144007.1",null,"Mus musculus neuroplastin (Nptn), transcript variant 2, mRNA","Mus musculus",1271,2335,{"v":0.02,"d":"2%"},0,89.22,2042,"NM_001293673.2"]
["Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030463G20 product:unclassifiable, full insert sequence","Mus musculus",270,931,{"v":0.04,"d":"4%"},{"v":5e-68,"d":"5.00E-68"},84.15,1883,"AK078768.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",265,5627,{"v":0.05,"d":"5%"},{"v":1e-66,"d":"1.00E-66"},82.87,79250,"ON637243.1",null,"Mus musculus musculus strain C57BL/10 chromosome 1 sequence","Mus musculus musculus",494,{"v":2235000,"d":"2.24E+06"},{"v":0.17,"d":"17%"},{"v":8e-135,"d":"8.00E-135"},96.04,1899750,"OK040659.1",null,"Mus musculus glutaredoxin, cysteine rich 1 (Grxcr1), mRNA","Mus musculus",483,591,{"v":0,"d":"0%"},{"v":3E-131,"d":"3.00E-131"},84.26,1127,"NM_001018019.3",{"$nulls":11},"Mus musculus Tric mRNA, complete cds","Mus musculus",1075,1436,{"v":0.05,"d":"5%"},0,83.69,1668,"AB219935.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014J03 product:unclassifiable, full insert sequence","Mus musculus",366,2214,{"v":0.04,"d":"4%"},{"v":1e-96,"d":"1.00E-96"},79.13,1592,"AK156276.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X4, misc_RNA","Mus musculus",1271,3116,{"v":0.03,"d":"3%"},0,89.22,2537,"XR_004935351.1"]
["Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",270,13105,{"v":0.05,"d":"5%"},{"v":5e-68,"d":"5.00E-68"},83.9,79250,"ON637243.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005C04 product:unclassifiable, full insert sequence","Mus musculus",263,452,{"v":0.03,"d":"3%"},{"v":5e-66,"d":"5.00E-66"},83.22,2680,"AK169942.1",null,"Mus musculus musculus strain O20 chromosome 1 sequence","Mus musculus musculus",494,{"v":2235000,"d":"2.24E+06"},{"v":0.17,"d":"17%"},{"v":8e-135,"d":"8.00E-135"},96.04,1899751,"OK040667.1",null,"Mus musculus glutaredoxin, cysteine rich 1, mRNA (cDNA clone MGC:182434 IMAGE:9056328), complete cds","Mus musculus",473,582,{"v":0,"d":"0%"},{"v":2e-128,"d":"2.00E-128"},86.82,964,"BC147268.1",{"$nulls":11},"Mus musculus MARVEL (membrane-associating) domain containing 2, mRNA (cDNA clone IMAGE:3583970), partial cds","Mus musculus",756,982,{"v":0.03,"d":"3%"},0,85.04,2617,"BC003296.2",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",337,29275,{"v":0.05,"d":"5%"},{"v":1E-87,"d":"1.00E-87"},86.34,79250,"ON637243.1",null,"Mus musculus neuroplastin (Nptn), transcript variant 5, mRNA","Mus musculus",1271,2969,{"v":0.03,"d":"3%"},0,89.22,2402,"NM_001406062.1"]
["Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630031M20 product:unclassifiable, full insert sequence","Mus musculus",268,1303,{"v":0.05,"d":"5%"},{"v":2e-67,"d":"2.00E-67"},87.45,1707,"AK170220.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830103D19 product:unclassifiable, full insert sequence","Mus musculus",259,434,{"v":0.03,"d":"3%"},{"v":7e-65,"d":"7.00E-65"},83.22,1265,"AK156850.1",null,"Mus musculus B6D2F1 clone 2C4D mRNA","Mus musculus",492,492,{"v":0.01,"d":"1%"},{"v":3E-134,"d":"3.00E-134"},86.83,959,"U01138.1",null,"Mus musculus glutaredoxin cysteine-rich 1 protein (Grxcr1) mRNA, complete cds","Mus musculus",473,582,{"v":0,"d":"0%"},{"v":2e-128,"d":"2.00E-128"},86.82,1088,"AY616753.1",{"$nulls":11},"Mus musculus strain C57BL/6J tricellulin isoform b (Marveld2) mRNA, complete cds","Mus musculus",730,1091,{"v":0.03,"d":"3%"},0,85.94,1437,"DQ682660.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",331,22702,{"v":0.06,"d":"6%"},{"v":5e-86,"d":"5.00E-86"},86.16,70497,"ON637244.1",null,"Mus musculus neuroplastin (Nptn), transcript variant 4, non-coding RNA","Mus musculus",1271,1970,{"v":0.02,"d":"2%"},0,89.22,1936,"NR_151824.2"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Cib2:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",257,696,{"v":0.02,"d":"2%"},{"v":4e-64,"d":"4.00E-64"},86.7,37996,"JN962237.1",null,"Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030463G20 product:unclassifiable, full insert sequence","Mus musculus",246,246,{"v":0.02,"d":"2%"},{"v":5e-61,"d":"5.00E-61"},82.21,1883,"AK078768.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",460,{"v":122700,"d":"1.23E+05"},{"v":0.11,"d":"11%"},{"v":8e-125,"d":"8.00E-125"},84.78,596397,"OK040662.1",null,"Mus musculus clone C42 LINE element sequence","Mus musculus",416,416,{"v":0,"d":"0%"},{"v":3e-111,"d":"3.00E-111"},94.07,278,"KT283024.1",{"$nulls":11},"Mus musculus musculus strain C57BL/10 chromosome 1 sequence","Mus musculus musculus",617,{"v":1707000,"d":"1.71E+06"},{"v":0.43,"d":"43%"},{"v":2e-172,"d":"2.00E-172"},83.73,1899750,"OK040659.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530008A19 product:hypothetical protein, full insert sequence","Mus musculus",324,4087,{"v":0.07,"d":"7%"},{"v":9e-84,"d":"9.00E-84"},86.42,4959,"AK149653.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X6, misc_RNA","Mus musculus",1271,2604,{"v":0.03,"d":"3%"},0,89.22,2326,"XR_004935352.1"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Sh2d7:tm2e(KOMP)Ucd; transgenic","Mus musculus",257,575,{"v":0.02,"d":"2%"},{"v":4e-64,"d":"4.00E-64"},86.7,38583,"JN952832.1",null,"Mus musculus clone 19 dsRNA sequence","Mus musculus",241,241,{"v":0.01,"d":"1%"},{"v":2e-59,"d":"2.00E-59"},85.48,241,"FJ041342.1",null,"Mus musculus MOB family member 4, phocein (Mob4), transcript variant 2, mRNA","Mus musculus",449,449,{"v":0.01,"d":"1%"},{"v":2E-121,"d":"2.00E-121"},87.22,2782,"NM_001310585.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530101D17 product:unclassifiable, full insert sequence","Mus musculus",363,1557,{"v":0.01,"d":"1%"},{"v":4E-95,"d":"4.00E-95"},89.58,3223,"AK144007.1",{"$nulls":11},"Mus musculus musculus strain O20 chromosome 1 sequence","Mus musculus musculus",617,{"v":1707000,"d":"1.71E+06"},{"v":0.43,"d":"43%"},{"v":2e-172,"d":"2.00E-172"},83.73,1899751,"OK040667.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630221F08 product:unclassifiable, full insert sequence","Mus musculus",324,4191,{"v":0.08,"d":"8%"},{"v":9e-84,"d":"9.00E-84"},86.42,6620,"AK171052.1",null,"Mus musculus adult male brain cDNA, RIKEN full-length enriched library, clone:0710007A22 product:stromal cell derived factor receptor 1, full insert sequence","Mus musculus",1269,2327,{"v":0.02,"d":"2%"},0,89.21,1899,"AK075610.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Sh2d7:tm2a(KOMP)Ucd tm1a(KOMP)Ucd; transgenic","Mus musculus",257,575,{"v":0.02,"d":"2%"},{"v":4e-64,"d":"4.00E-64"},86.7,38565,"JN950676.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530101D17 product:unclassifiable, full insert sequence","Mus musculus",239,239,{"v":0.02,"d":"2%"},{"v":9e-59,"d":"9.00E-59"},81.55,3223,"AK144007.1",null,"Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430045P06 product:preimplantation protein 3, full insert sequence","Mus musculus",442,442,{"v":0,"d":"0%"},{"v":3e-119,"d":"3.00E-119"},88.77,3548,"AK034840.1",null,"Mus musculus partial mRNA for Grxcr1 novel isoform (Grxcr1 gene), strain Mus musculus","Mus musculus",361,471,{"v":0,"d":"0%"},{"v":1e-94,"d":"1.00E-94"},85.84,453,"OW028383.1",{"$nulls":11},"Mus musculus strain C57BL/6J tricellulin isoform c (Marveld2) mRNA, complete cds","Mus musculus",599,959,{"v":0.03,"d":"3%"},{"v":6e-167,"d":"6.00E-167"},86.67,1291,"DQ682661.1",null,"Mus musculus clone 19 dsRNA sequence","Mus musculus",311,2438,{"v":0.03,"d":"3%"},{"v":7e-80,"d":"7.00E-80"},90.04,241,"FJ041342.1",null,"Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430007B05 product:stromal cell derived factor receptor 1, full insert sequence","Mus musculus",1253,2311,{"v":0.02,"d":"2%"},0,89.11,1900,"AK153930.1"]
["Mus musculus BAC clone RP23-311C13 from chromosome 9, complete sequence","Mus musculus",257,696,{"v":0.02,"d":"2%"},{"v":4e-64,"d":"4.00E-64"},86.7,213461,"AC157591.2",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630024B09 product:unclassifiable, full insert sequence","Mus musculus",237,237,{"v":0.02,"d":"2%"},{"v":3e-58,"d":"3.00E-58"},83.33,3677,"AK154362.1",null,"Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030463G20 product:unclassifiable, full insert sequence","Mus musculus",427,4298,{"v":0.05,"d":"5%"},{"v":8e-115,"d":"8.00E-115"},84.68,1883,"AK078768.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005C04 product:unclassifiable, full insert sequence","Mus musculus",344,1859,{"v":0.01,"d":"1%"},{"v":1E-89,"d":"1.00E-89"},87.06,2680,"AK169942.1",{"$nulls":11},"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",590,{"v":1843000,"d":"1.84E+06"},{"v":0.42,"d":"42%"},{"v":4e-164,"d":"4.00E-164"},97.14,4855227,"OK040670.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530108P09 product:unclassifiable, full insert sequence","Mus musculus",302,2434,{"v":0.03,"d":"3%"},{"v":4e-77,"d":"4.00E-77"},90.25,3590,"AK165488.1",null,"Mus musculus SDR1 mRNA, complete cds","Mus musculus",1212,2270,{"v":0.02,"d":"2%"},0,88.37,1900,"D50463.1"]
["Mouse DNA sequence from clone RP23-259G10 on chromosome 9, complete sequence","Mus musculus",257,696,{"v":0.02,"d":"2%"},{"v":4e-64,"d":"4.00E-64"},86.7,213433,"CT010507.11",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Col9a2:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",235,621,{"v":0.08,"d":"8%"},{"v":1e-57,"d":"1.00E-57"},72.33,40352,"JN960378.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Elmod1:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",414,665,{"v":0.01,"d":"1%"},{"v":6e-111,"d":"6.00E-111"},84.06,38052,"JN954993.1",null,"Mus musculus chromosome 5, clone RP23-206B16, complete sequence","Mus musculus",339,692,{"v":0.01,"d":"1%"},{"v":7e-88,"d":"7.00E-88"},82.74,188575,"AC107758.19",{"$nulls":11},"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208N06 product:hypothetical protein, full insert sequence","Mus musculus",448,4113,{"v":0.15,"d":"15%"},{"v":2E-121,"d":"2.00E-121"},82.06,2137,"AK155211.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530113L21 product:unclassifiable, full insert sequence","Mus musculus",302,5183,{"v":0.06,"d":"6%"},{"v":4e-77,"d":"4.00E-77"},89.87,1204,"AK144028.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",689,{"v":1975000,"d":"1.98E+06"},{"v":0.12,"d":"12%"},0,88.52,4352563,"OK040673.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Cib2:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",257,696,{"v":0.02,"d":"2%"},{"v":4e-64,"d":"4.00E-64"},86.7,37971,"JN958343.1",null,"Mouse DNA sequence from clone RP23-227I2 on chromosome 4, complete sequence","Mus musculus",235,621,{"v":0.08,"d":"8%"},{"v":1e-57,"d":"1.00E-57"},72.33,124454,"AL669949.11",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Elmod1:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",414,665,{"v":0.01,"d":"1%"},{"v":6e-111,"d":"6.00E-111"},84.06,38094,"JN951040.1",null,"Mus musculus 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F430014O19 product:unclassifiable, full insert sequence","Mus musculus",333,333,{"v":0,"d":"0%"},{"v":3e-86,"d":"3.00E-86"},96.97,3061,"AK143738.1",{"$nulls":11},"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530008A19 product:hypothetical protein, full insert sequence","Mus musculus",407,2315,{"v":0.1,"d":"10%"},{"v":4E-109,"d":"4.00E-109"},86.63,4959,"AK149653.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630031M20 product:unclassifiable, full insert sequence","Mus musculus",302,3735,{"v":0.05,"d":"5%"},{"v":4e-77,"d":"4.00E-77"},90.39,1707,"AK170220.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",689,{"v":1975000,"d":"1.98E+06"},{"v":0.12,"d":"12%"},0,88.52,4352532,"OK040663.1"]
["Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830212P19 product:unclassifiable, full insert sequence","Mus musculus",250,1273,{"v":0.05,"d":"5%"},{"v":6e-62,"d":"6.00E-62"},86.38,3152,"AK157386.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Col9a2:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",235,621,{"v":0.08,"d":"8%"},{"v":1e-57,"d":"1.00E-57"},72.33,40276,"JN960550.1",null,"Mus musculus BAC clone RP24-174O15 from chromosome 9, complete sequence","Mus musculus",414,1748,{"v":0.03,"d":"3%"},{"v":6e-111,"d":"6.00E-111"},84.06,161849,"AC157476.2",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",333,6510,{"v":0.01,"d":"1%"},{"v":3e-86,"d":"3.00E-86"},88.11,79250,"ON637243.1",{"$nulls":11},"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630221F08 product:unclassifiable, full insert sequence","Mus musculus",407,2315,{"v":0.1,"d":"10%"},{"v":4E-109,"d":"4.00E-109"},86.63,6620,"AK171052.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630024B09 product:unclassifiable, full insert sequence","Mus musculus",279,1680,{"v":0.03,"d":"3%"},{"v":2E-70,"d":"2.00E-70"},84.54,3677,"AK154362.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X8, mRNA","Mus musculus",634,1202,{"v":0.01,"d":"1%"},{"v":4e-177,"d":"4.00E-177"},99.43,1241,"XM_036154740.1"]
["Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630024B09 product:unclassifiable, full insert sequence","Mus musculus",243,243,{"v":0.01,"d":"1%"},{"v":1E-59,"d":"1.00E-59"},85.71,3677,"AK154362.1",null,"M.musculus alpha2 (IX) collagen gene, complete CDS","Mus musculus",231,600,{"v":0.08,"d":"8%"},{"v":1E-56,"d":"1.00E-56"},72.18,19479,"Z22923.1",null,"Mus musculus ELMO/CED-12 domain containing 1 (Elmod1), transcript variant 1, mRNA","Mus musculus",411,759,{"v":0.01,"d":"1%"},{"v":8e-110,"d":"8.00E-110"},79.15,2668,"NM_001405021.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",327,5116,{"v":0.01,"d":"1%"},{"v":1E-84,"d":"1.00E-84"},85.76,70497,"ON637244.1",{"$nulls":11},"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530101D17 product:unclassifiable, full insert sequence","Mus musculus",366,3098,{"v":0.1,"d":"10%"},{"v":7e-97,"d":"7.00E-97"},82.52,3223,"AK144007.1",null,"Mus musculus transgenic strain FVB/N genomic sequence","Mus musculus",274,1227,{"v":0.02,"d":"2%"},{"v":9e-69,"d":"9.00E-69"},86.69,1477,"KU665646.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X9, mRNA","Mus musculus",634,1316,{"v":0.01,"d":"1%"},{"v":4e-177,"d":"4.00E-177"},99.43,1279,"XM_036154741.1"]
["Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630014M05 product:unclassifiable, full insert sequence","Mus musculus",243,690,{"v":0.02,"d":"2%"},{"v":1E-59,"d":"1.00E-59"},87.62,2096,"AK170071.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530113L21 product:unclassifiable, full insert sequence","Mus musculus",224,441,{"v":0.03,"d":"3%"},{"v":2e-54,"d":"2.00E-54"},85.41,1204,"AK144028.1",null,"Mus musculus ELMO domain containing 1, mRNA (cDNA clone IMAGE:6392251), with apparent retained intron","Mus musculus",411,759,{"v":0.01,"d":"1%"},{"v":8e-110,"d":"8.00E-110"},79.15,2291,"BC049160.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530108P09 product:unclassifiable, full insert sequence","Mus musculus",327,630,{"v":0,"d":"0%"},{"v":1E-84,"d":"1.00E-84"},92.54,3590,"AK165488.1",{"$nulls":11},"Mus musculus clone 19 dsRNA sequence","Mus musculus",320,1690,{"v":0.05,"d":"5%"},{"v":5e-83,"d":"5.00E-83"},91.14,241,"FJ041342.1",null,"Mus musculus strain 129/Sv transgenic line PWScrdel genomic sequence","Mus musculus",274,1775,{"v":0.03,"d":"3%"},{"v":9e-69,"d":"9.00E-69"},86.22,4737,"EU233428.1",null,"PREDICTED: Mus musculus neuroplastin (Nptn), transcript variant X5, mRNA","Mus musculus",634,1311,{"v":0.01,"d":"1%"},{"v":4e-177,"d":"4.00E-177"},99.43,1268,"XM_036154739.1"]
["Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810434I23 product:kinase interacting protein 2, full insert sequence","Mus musculus",237,527,{"v":0.02,"d":"2%"},{"v":5e-58,"d":"5.00E-58"},88.32,1401,"AK013240.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830212P19 product:unclassifiable, full insert sequence","Mus musculus",220,603,{"v":0.04,"d":"4%"},{"v":3e-53,"d":"3.00E-53"},84.82,3152,"AK157386.1",null,"Mus musculus ELMO/CED-12 domain containing 1 (Elmod1), transcript variant 3, mRNA","Mus musculus",411,759,{"v":0.01,"d":"1%"},{"v":8e-110,"d":"8.00E-110"},79.15,2682,"NM_001405022.1",null,"Mus musculus clone 19 dsRNA sequence","Mus musculus",307,1082,{"v":0.01,"d":"1%"},{"v":2E-78,"d":"2.00E-78"},89.63,241,"FJ041342.1",{"$nulls":11},"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",318,14673,{"v":0.08,"d":"8%"},{"v":2e-82,"d":"2.00E-82"},86.24,70497,"ON637244.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530102J11 product:unclassifiable, full insert sequence","Mus musculus",265,2098,{"v":0.04,"d":"4%"},{"v":6e-66,"d":"6.00E-66"},82.74,687,"AK144010.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",630,{"v":2576000,"d":"2.58E+06"},{"v":0.09,"d":"9%"},{"v":5E-176,"d":"5.00E-176"},86.76,15712434,"OK040665.1"]
["Mus musculus mRNA for calcium binding protein Kip 2, complete cds","Mus musculus",237,527,{"v":0.02,"d":"2%"},{"v":5e-58,"d":"5.00E-58"},88.32,736,"AB016080.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530115C12 product:unclassifiable, full insert sequence","Mus musculus",217,661,{"v":0.04,"d":"4%"},{"v":4E-52,"d":"4.00E-52"},80.99,2020,"AK165491.1",null,"Mus musculus ELMO/CED-12 domain containing 1 (Elmod1), transcript variant 2, mRNA","Mus musculus",411,759,{"v":0.01,"d":"1%"},{"v":8e-110,"d":"8.00E-110"},79.15,2644,"NM_177769.5",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005B03 product:unclassifiable, full insert sequence","Mus musculus",303,303,{"v":0,"d":"0%"},{"v":2e-77,"d":"2.00E-77"},94.44,3064,"AK154154.1",{"$nulls":11},"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",318,19100,{"v":0.07,"d":"7%"},{"v":2e-82,"d":"2.00E-82"},86.24,79250,"ON637243.1",null,"Mus musculus clone 29 dsRNA sequence","Mus musculus",263,393,{"v":0.01,"d":"1%"},{"v":2e-65,"d":"2.00E-65"},83.94,280,"FJ041345.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",614,{"v":2558000,"d":"2.56E+06"},{"v":0.09,"d":"9%"},{"v":5e-171,"d":"5.00E-171"},85.98,16711841,"OK040661.1"]
["PREDICTED: Mus musculus calcium and integrin binding family member 2 (Cib2), transcript variant X1, mRNA","Mus musculus",237,525,{"v":0.02,"d":"2%"},{"v":5e-58,"d":"5.00E-58"},88.32,1520,"XM_036155147.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530102J11 product:unclassifiable, full insert sequence","Mus musculus",213,412,{"v":0.03,"d":"3%"},{"v":5E-51,"d":"5.00E-51"},80.34,687,"AK144010.1",null,"PREDICTED: Mus musculus ELMO/CED-12 domain containing 1 (Elmod1), transcript variant X2, mRNA","Mus musculus",411,759,{"v":0.01,"d":"1%"},{"v":8e-110,"d":"8.00E-110"},79.15,2713,"XM_006511206.4",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630031M20 product:unclassifiable, full insert sequence","Mus musculus",300,780,{"v":0,"d":"0%"},{"v":3e-76,"d":"3.00E-76"},90.04,1707,"AK170220.1",{"$nulls":11},"Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030463G20 product:unclassifiable, full insert sequence","Mus musculus",300,3513,{"v":0.13,"d":"13%"},{"v":7e-77,"d":"7.00E-77"},77.38,1883,"AK078768.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830212P19 product:unclassifiable, full insert sequence","Mus musculus",259,1917,{"v":0.03,"d":"3%"},{"v":3e-64,"d":"3.00E-64"},87.28,3152,"AK157386.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",564,{"v":601300,"d":"6.01E+05"},{"v":0.13,"d":"13%"},{"v":5e-156,"d":"5.00E-156"},84.54,3752979,"OK040666.1"]
["PREDICTED: Mus musculus calcium and integrin binding family member 2 (Cib2), transcript variant X2, mRNA","Mus musculus",237,430,{"v":0.01,"d":"1%"},{"v":5e-58,"d":"5.00E-58"},88.32,1306,"XM_036155148.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630031M20 product:unclassifiable, full insert sequence","Mus musculus",211,575,{"v":0.04,"d":"4%"},{"v":2E-50,"d":"2.00E-50"},84.21,1707,"AK170220.1",null,"Mus musculus adult male brain cDNA, RIKEN full-length enriched library, clone:3632436G04 product:hypothetical Engulfment and cell motility, ELM containing protein, full insert sequence","Mus musculus",407,755,{"v":0.01,"d":"1%"},{"v":1E-108,"d":"1.00E-108"},79.15,2607,"AK132239.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530113L21 product:unclassifiable, full insert sequence","Mus musculus",296,1163,{"v":0.01,"d":"1%"},{"v":4e-75,"d":"4.00E-75"},90.04,1204,"AK144028.1",{"$nulls":11},"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630024B09 product:unclassifiable, full insert sequence","Mus musculus",274,1474,{"v":0.06,"d":"6%"},{"v":4e-69,"d":"4.00E-69"},87.5,3677,"AK154362.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630014M05 product:unclassifiable, full insert sequence","Mus musculus",246,1797,{"v":0.03,"d":"3%"},{"v":2e-60,"d":"2.00E-60"},86.4,2096,"AK170071.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",556,{"v":1732000,"d":"1.73E+06"},{"v":0.13,"d":"13%"},{"v":9e-154,"d":"9.00E-154"},84.42,5060266,"OK040664.1"]
["Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA","Mus musculus",237,527,{"v":0.02,"d":"2%"},{"v":5e-58,"d":"5.00E-58"},88.32,1421,"NM_019686.6",null,"Mus musculus clone 100 dsRNA sequence","Mus musculus",202,202,{"v":0.02,"d":"2%"},{"v":1e-47,"d":"1.00E-47"},81.08,256,"FJ041375.1",null,"Mus musculus 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530013I15 product:hypothetical Engulfment and cell motility, ELM containing protein, full insert sequence","Mus musculus",405,753,{"v":0.01,"d":"1%"},{"v":4e-108,"d":"4.00E-108"},79,3000,"AK164094.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630024B09 product:unclassifiable, full insert sequence","Mus musculus",292,572,{"v":0,"d":"0%"},{"v":5E-74,"d":"5.00E-74"},86.59,3677,"AK154362.1",{"$nulls":11},"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005C04 product:unclassifiable, full insert sequence","Mus musculus",272,2637,{"v":0.08,"d":"8%"},{"v":1e-68,"d":"1.00E-68"},83.85,2680,"AK169942.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630037E14 product:unclassifiable, full insert sequence","Mus musculus",239,3676,{"v":0.04,"d":"4%"},{"v":3e-58,"d":"3.00E-58"},93.71,1663,"AK089204.1",null,"Mus musculus musculus strain O20 chromosome 17 sequence","Mus musculus musculus",556,{"v":1731000,"d":"1.73E+06"},{"v":0.13,"d":"13%"},{"v":9e-154,"d":"9.00E-154"},84.42,5060235,"OK040674.1"]
["Mus musculus adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500032N14 product:kinase interacting protein 2, full insert sequence","Mus musculus",237,527,{"v":0.02,"d":"2%"},{"v":5e-58,"d":"5.00E-58"},88.32,893,"AK005347.1",null,"Mus musculus clone 22 dsRNA sequence","Mus musculus",193,193,{"v":0.01,"d":"1%"},{"v":7E-45,"d":"7.00E-45"},89.03,185,"FJ041343.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530101D17 product:unclassifiable, full insert sequence","Mus musculus",383,5292,{"v":0.05,"d":"5%"},{"v":2e-101,"d":"2.00E-101"},89.67,3223,"AK144007.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208N06 product:hypothetical protein, full insert sequence","Mus musculus",292,1925,{"v":0.01,"d":"1%"},{"v":5E-74,"d":"5.00E-74"},84.39,2137,"AK155211.1",{"$nulls":11},"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530102J11 product:unclassifiable, full insert sequence","Mus musculus",272,1506,{"v":0.06,"d":"6%"},{"v":1e-68,"d":"1.00E-68"},83.67,687,"AK144010.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530115C12 product:unclassifiable, full insert sequence","Mus musculus",231,2699,{"v":0.05,"d":"5%"},{"v":6e-56,"d":"6.00E-56"},82.01,2020,"AK165491.1",null,"Mus musculus musculus strain C57BL/10 chromosome 1 sequence","Mus musculus musculus",542,{"v":1073000,"d":"1.07E+06"},{"v":0.12,"d":"12%"},{"v":3e-149,"d":"3.00E-149"},83.64,1899750,"OK040659.1"]
["Mus musculus calcium and integrin binding family member 2, mRNA (cDNA clone MGC:11420 IMAGE:3599342), complete cds","Mus musculus",231,522,{"v":0.02,"d":"2%"},{"v":2e-56,"d":"2.00E-56"},87.82,867,"BC005739.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630014M05 product:unclassifiable, full insert sequence","Mus musculus",193,378,{"v":0.03,"d":"3%"},{"v":7E-45,"d":"7.00E-45"},82.73,2096,"AK170071.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005C04 product:unclassifiable, full insert sequence","Mus musculus",383,4285,{"v":0.05,"d":"5%"},{"v":2e-101,"d":"2.00E-101"},89.74,2680,"AK169942.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530102J11 product:unclassifiable, full insert sequence","Mus musculus",283,487,{"v":0,"d":"0%"},{"v":3e-71,"d":"3.00E-71"},84.12,687,"AK144010.1",{"$nulls":11},"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830212P19 product:unclassifiable, full insert sequence","Mus musculus",261,2022,{"v":0.07,"d":"7%"},{"v":3E-65,"d":"3.00E-65"},87.07,3152,"AK157386.1",null,"Mus musculus BAC clone RP23-354F11 from chromosome 16, complete sequence","Mus musculus",222,996,{"v":0.01,"d":"1%"},{"v":3e-53,"d":"3.00E-53"},90.48,199488,"AC167018.4",null,"Mus musculus musculus strain O20 chromosome 1 sequence","Mus musculus musculus",542,{"v":1073000,"d":"1.07E+06"},{"v":0.12,"d":"12%"},{"v":3e-149,"d":"3.00E-149"},83.64,1899751,"OK040667.1"]
["Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530115C12 product:unclassifiable, full insert sequence","Mus musculus",231,805,{"v":0.03,"d":"3%"},{"v":2e-56,"d":"2.00E-56"},88.21,2020,"AK165491.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530008A19 product:hypothetical protein, full insert sequence","Mus musculus",193,373,{"v":0.03,"d":"3%"},{"v":7E-45,"d":"7.00E-45"},79.02,4959,"AK149653.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208N06 product:hypothetical protein, full insert sequence","Mus musculus",375,6596,{"v":0.07,"d":"7%"},{"v":3e-99,"d":"3.00E-99"},81.84,2137,"AK155211.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014J03 product:unclassifiable, full insert sequence","Mus musculus",272,924,{"v":0.01,"d":"1%"},{"v":7e-68,"d":"7.00E-68"},83.5,1592,"AK156276.1",{"$nulls":11},"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014J03 product:unclassifiable, full insert sequence","Mus musculus",259,1491,{"v":0.06,"d":"6%"},{"v":1e-64,"d":"1.00E-64"},83.57,1592,"AK156276.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Mgrn1:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",222,756,{"v":0.01,"d":"1%"},{"v":3e-53,"d":"3.00E-53"},89.27,40303,"JN952430.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",538,{"v":1563000,"d":"1.56E+06"},{"v":0.13,"d":"13%"},{"v":3E-148,"d":"3.00E-148"},83.72,9609886,"OK040671.1"]
["Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014J03 product:unclassifiable, full insert sequence","Mus musculus",230,884,{"v":0.04,"d":"4%"},{"v":8e-56,"d":"8.00E-56"},81.17,1592,"AK156276.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630221F08 product:unclassifiable, full insert sequence","Mus musculus",193,373,{"v":0.03,"d":"3%"},{"v":7E-45,"d":"7.00E-45"},79.02,6620,"AK171052.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",363,24789,{"v":0.05,"d":"5%"},{"v":2E-95,"d":"2.00E-95"},88.7,70497,"ON637244.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630036A16 product:hypothetical protein, full insert sequence","Mus musculus",270,270,{"v":0,"d":"0%"},{"v":3e-67,"d":"3.00E-67"},91.41,4754,"AK154459.1",{"$nulls":11},"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530108P09 product:unclassifiable, full insert sequence","Mus musculus",257,1310,{"v":0.04,"d":"4%"},{"v":4e-64,"d":"4.00E-64"},90.31,3590,"AK165488.1",null,"Mus musculus BAC clone CH25-5C6 from chromosome 16, complete sequence","Mus musculus",222,996,{"v":0.01,"d":"1%"},{"v":3e-53,"d":"3.00E-53"},90.48,126852,"AC240849.2",null,"Mus musculus musculus strain C57BL/10 chromosome 15 sequence","Mus musculus musculus",534,{"v":651800,"d":"6.52E+05"},{"v":0.12,"d":"12%"},{"v":4e-147,"d":"4.00E-147"},83.58,2566542,"OK040660.1"]
["Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530101D17 product:unclassifiable, full insert sequence","Mus musculus",220,351,{"v":0.02,"d":"2%"},{"v":5E-53,"d":"5.00E-53"},80.84,3223,"AK144007.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630037E14 product:unclassifiable, full insert sequence","Mus musculus",161,527,{"v":0.03,"d":"3%"},{"v":2E-35,"d":"2.00E-35"},86.49,1663,"AK089204.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",363,31872,{"v":0.05,"d":"5%"},{"v":2E-95,"d":"2.00E-95"},88.93,79250,"ON637243.1",null,"Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030463G20 product:unclassifiable, full insert sequence","Mus musculus",267,959,{"v":0.01,"d":"1%"},{"v":3e-66,"d":"3.00E-66"},84.31,1883,"AK078768.1",{"$nulls":11},"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630031M20 product:unclassifiable, full insert sequence","Mus musculus",250,1957,{"v":0.07,"d":"7%"},{"v":7e-62,"d":"7.00E-62"},87.61,1707,"AK170220.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Mgrn1:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",222,756,{"v":0.01,"d":"1%"},{"v":3e-53,"d":"3.00E-53"},89.27,40325,"JN962722.1",null,"Mus musculus musculus strain C57BL/10 chromosome 18 sequence","Mus musculus musculus",527,{"v":1123000,"d":"1.12E+06"},{"v":0.13,"d":"13%"},{"v":7e-145,"d":"7.00E-145"},83.39,4855227,"OK040670.1"]
["Mus musculus clone 100 dsRNA sequence","Mus musculus",207,793,{"v":0.04,"d":"4%"},{"v":4e-49,"d":"4.00E-49"},81.71,256,"FJ041375.1",null,"M.musculus mRNA for alpha2(IX)collagen fragment","Mus musculus",106,106,{"v":0,"d":"0%"},{"v":9e-19,"d":"9.00E-19"},90.12,444,"X63014.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530008A19 product:hypothetical protein, full insert sequence","Mus musculus",333,2582,{"v":0.04,"d":"4%"},{"v":2e-86,"d":"2.00E-86"},87.13,4959,"AK149653.1",null,"Mus musculus clone C10 LINE element sequence","Mus musculus",254,254,{"v":0,"d":"0%"},{"v":3e-62,"d":"3.00E-62"},94.58,229,"KT283013.1",{"$nulls":11},"Mus musculus clone 1 dsRNA sequence","Mus musculus",250,620,{"v":0.02,"d":"2%"},{"v":7e-62,"d":"7.00E-62"},87.91,216,"FJ041333.1",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 7, mRNA","Mus musculus",211,852,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3209,"NM_001379014.1",null,"Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030463G20 product:unclassifiable, full insert sequence","Mus musculus",385,1902,{"v":0.02,"d":"2%"},{"v":5e-102,"d":"5.00E-102"},80.26,1883,"AK078768.1"]
["Mus musculus clone 1 dsRNA sequence","Mus musculus",204,490,{"v":0.02,"d":"2%"},{"v":5e-48,"d":"5.00E-48"},84.51,216,"FJ041333.1",null,"Mus musculus collagen, type IX, alpha 2 (Col9a2), mRNA","Mus musculus",106,383,{"v":0.01,"d":"1%"},{"v":9e-19,"d":"9.00E-19"},90.12,2746,"NM_007741.2",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630221F08 product:unclassifiable, full insert sequence","Mus musculus",333,2582,{"v":0.04,"d":"4%"},{"v":2e-86,"d":"2.00E-86"},87.13,6620,"AK171052.1",null,"Mus musculus clone contig 75 chromocenter region genomic sequence","Mus musculus",239,239,{"v":0,"d":"0%"},{"v":7e-58,"d":"7.00E-58"},98.52,354,"KX121681.1",{"$nulls":11},"Mus musculus clone 29 dsRNA sequence","Mus musculus",241,241,{"v":0.01,"d":"1%"},{"v":4e-59,"d":"4.00E-59"},82.5,280,"FJ041345.1",null,"Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430019K14 product:hypothetical Crystallin/RING finger containing protein, full insert sequence","Mus musculus",211,735,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3069,"AK088533.1",null,"Mus musculus musculus strain C57BL/10 chromosome 17 sequence","Mus musculus musculus",377,98512,{"v":0.1,"d":"10%"},{"v":8e-100,"d":"8.00E-100"},83.22,596397,"OK040662.1"]
["Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530102J11 product:unclassifiable, full insert sequence","Mus musculus",200,647,{"v":0.03,"d":"3%"},{"v":7e-47,"d":"7.00E-47"},90.73,687,"AK144010.1",null,"Mus musculus collagen, type IX, alpha 2, mRNA (cDNA clone MGC:36115 IMAGE:5355825), complete cds","Mus musculus",102,377,{"v":0.01,"d":"1%"},{"v":1e-17,"d":"1.00E-17"},100,2718,"BC029697.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530102J11 product:unclassifiable, full insert sequence","Mus musculus",333,1437,{"v":0.02,"d":"2%"},{"v":2e-86,"d":"2.00E-86"},80.74,687,"AK144010.1",null,"Mus musculus clone 100 dsRNA sequence","Mus musculus",235,410,{"v":0,"d":"0%"},{"v":9e-57,"d":"9.00E-57"},83.4,256,"FJ041375.1",{"$nulls":11},"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530113L21 product:unclassifiable, full insert sequence","Mus musculus",235,1564,{"v":0.05,"d":"5%"},{"v":2e-57,"d":"2.00E-57"},85.28,1204,"AK144028.1",null,"Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610042J20 product:hypothetical Crystallin/RING finger containing protein, full insert sequence","Mus musculus",211,648,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,2009,"AK011747.2",null,"Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4921539A16 product:stromal cell derived factor receptor 1, full insert sequence","Mus musculus",364,889,{"v":0.01,"d":"1%"},{"v":6e-96,"d":"6.00E-96"},90.36,1401,"AK076624.1"]
["Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530113L21 product:unclassifiable, full insert sequence","Mus musculus",191,600,{"v":0.02,"d":"2%"},{"v":4e-44,"d":"4.00E-44"},82.3,1204,"AK144028.1",null,"Mus musculus targeted deletion, lacZ-tagged mutant allele 2810405K02Rik:tm1(KOMP)Ucd; transgenic","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},91.67,37222,"JN961483.1",null,"Mus musculus clone 19 dsRNA sequence","Mus musculus",324,1666,{"v":0.02,"d":"2%"},{"v":1E-83,"d":"1.00E-83"},90.87,241,"FJ041342.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630014M05 product:unclassifiable, full insert sequence","Mus musculus",230,230,{"v":0,"d":"0%"},{"v":4E-55,"d":"4.00E-55"},84.39,2096,"AK170071.1",{"$nulls":11},"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530115C12 product:unclassifiable, full insert sequence","Mus musculus",230,2411,{"v":0.08,"d":"8%"},{"v":9e-56,"d":"9.00E-56"},81.88,2020,"AK165491.1",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 2, mRNA","Mus musculus",211,738,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3290,"NM_029657.4",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530101D17 product:unclassifiable, full insert sequence","Mus musculus",350,2299,{"v":0.03,"d":"3%"},{"v":2E-91,"d":"2.00E-91"},87.79,3223,"AK144007.1"]
["Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830103D19 product:unclassifiable, full insert sequence","Mus musculus",189,189,{"v":0.01,"d":"1%"},{"v":1e-43,"d":"1.00E-43"},84.58,1265,"AK156850.1",null,"Mouse DNA sequence from clone RP23-15L19 on chromosome 4, complete sequence","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},92.98,136416,"AL607032.16",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014J03 product:unclassifiable, full insert sequence","Mus musculus",318,4115,{"v":0.06,"d":"6%"},{"v":5e-82,"d":"5.00E-82"},86.53,1592,"AK156276.1",null,"Mus musculus clone 22 dsRNA sequence","Mus musculus",226,586,{"v":0,"d":"0%"},{"v":6e-54,"d":"6.00E-54"},92.9,185,"FJ041343.1",{"$nulls":11},"Mus musculus transgenic strain FVB/N genomic sequence","Mus musculus",230,401,{"v":0.01,"d":"1%"},{"v":9e-56,"d":"9.00E-56"},83.27,1477,"KU665646.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530141N15 product:mahogunin, ring finger 1, full insert sequence","Mus musculus",211,634,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,2251,"AK150176.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",331,11201,{"v":0.03,"d":"3%"},{"v":6e-86,"d":"6.00E-86"},86.89,70497,"ON637244.1"]
["Mus musculus clone 87 dsRNA sequence","Mus musculus",169,169,{"v":0.01,"d":"1%"},{"v":2e-37,"d":"2.00E-37"},86.36,205,"FJ041370.1",null,"Mus musculus BAC clone RP23-364E18 from 5, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":6E-11,"d":"6.00E-11"},84.52,190505,"AC125048.2",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530108P09 product:unclassifiable, full insert sequence","Mus musculus",313,1522,{"v":0.02,"d":"2%"},{"v":2e-80,"d":"2.00E-80"},92.63,3590,"AK165488.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830212P19 product:unclassifiable, full insert sequence","Mus musculus",220,406,{"v":0,"d":"0%"},{"v":3E-52,"d":"3.00E-52"},84.21,3152,"AK157386.1",{"$nulls":11},"Mus musculus strain 129/Sv transgenic line PWScrdel genomic sequence","Mus musculus",230,836,{"v":0.03,"d":"3%"},{"v":9e-56,"d":"9.00E-56"},83.27,4737,"EU233428.1",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 9, non-coding RNA","Mus musculus",211,850,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3213,"NR_166412.1",null,"Mus musculus transgenic K18-hACE2_PrlmnJ sequence","Mus musculus",331,14412,{"v":0.02,"d":"2%"},{"v":6e-86,"d":"6.00E-86"},86.89,79250,"ON637243.1"]
["Mus musculus clone 22 dsRNA sequence","Mus musculus",163,398,{"v":0.02,"d":"2%"},{"v":9e-36,"d":"9.00E-36"},84.85,185,"FJ041343.1",null,"Mus musculus BAC clone RP23-237H9 from chromosome 5, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":6E-11,"d":"6.00E-11"},89.23,194736,"AC126271.4",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630031M20 product:unclassifiable, full insert sequence","Mus musculus",311,2193,{"v":0.03,"d":"3%"},{"v":8e-80,"d":"8.00E-80"},91.23,1707,"AK170220.1",null,"Mus musculus clone 724 CTCF-binding site sequence","Mus musculus",220,220,{"v":0,"d":"0%"},{"v":3E-52,"d":"3.00E-52"},92.41,165,"AY457434.1",{"$nulls":11},"Mus musculus MARVEL (membrane-associating) domain containing 2 (Marveld2), transcript variant 2, mRNA","Mus musculus",226,360,{"v":0.01,"d":"1%"},{"v":1E-54,"d":"1.00E-54"},90.17,2203,"NM_178410.3",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 8, mRNA","Mus musculus",211,648,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,2590,"NM_001379015.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530008A19 product:hypothetical protein, full insert sequence","Mus musculus",316,1167,{"v":0.02,"d":"2%"},{"v":2e-81,"d":"2.00E-81"},86.2,4959,"AK149653.1"]
["Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630037E14 product:unclassifiable, full insert sequence","Mus musculus",161,466,{"v":0.02,"d":"2%"},{"v":3e-35,"d":"3.00E-35"},85.19,1663,"AK089204.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Ssr2:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},93.75,37860,"JN963998.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530113L21 product:unclassifiable, full insert sequence","Mus musculus",307,3042,{"v":0.03,"d":"3%"},{"v":1E-78,"d":"1.00E-78"},90.91,1204,"AK144028.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530115C12 product:unclassifiable, full insert sequence","Mus musculus",215,802,{"v":0.01,"d":"1%"},{"v":1E-50,"d":"1.00E-50"},81.34,2020,"AK165491.1",{"$nulls":11},"Mus musculus MARVEL (membrane-associating) domain containing 2, mRNA (cDNA clone IMAGE:40130633), complete cds","Mus musculus",226,360,{"v":0.01,"d":"1%"},{"v":1E-54,"d":"1.00E-54"},90.17,584,"BC132356.1",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 1, mRNA","Mus musculus",211,740,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3293,"NM_001252437.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630221F08 product:unclassifiable, full insert sequence","Mus musculus",316,1167,{"v":0.02,"d":"2%"},{"v":2e-81,"d":"2.00E-81"},86.2,6620,"AK171052.1"]
["Mus musculus clone 193 CTCF-binding site sequence","Mus musculus",124,359,{"v":0.01,"d":"1%"},{"v":4e-24,"d":"4.00E-24"},86.32,170,"AY457245.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Xpr1:tm1a(KOMP)Wtsi; transgenic","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},93.75,37974,"JN963226.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630024B09 product:unclassifiable, full insert sequence","Mus musculus",300,1086,{"v":0.01,"d":"1%"},{"v":2e-76,"d":"2.00E-76"},89.54,3677,"AK154362.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630037E14 product:unclassifiable, full insert sequence","Mus musculus",206,784,{"v":0,"d":"0%"},{"v":7e-48,"d":"7.00E-48"},88.37,1663,"AK089204.1",{"$nulls":11},"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630014M05 product:unclassifiable, full insert sequence","Mus musculus",224,1317,{"v":0.05,"d":"5%"},{"v":4e-54,"d":"4.00E-54"},86.12,2096,"AK170071.1",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 3, mRNA","Mus musculus",211,738,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3245,"NM_001357061.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830014J03 product:unclassifiable, full insert sequence","Mus musculus",309,1955,{"v":0.03,"d":"3%"},{"v":3E-79,"d":"3.00E-79"},85.52,1592,"AK156276.1"]
["Mus musculus clone 161 CTCF-binding site sequence","Mus musculus",124,359,{"v":0.01,"d":"1%"},{"v":4e-24,"d":"4.00E-24"},86.32,169,"AY457231.1",null,"Mus musculus chromosome 1, clone RP23-105A17, complete sequence","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},93.75,179782,"AC116712.11",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530115C12 product:unclassifiable, full insert sequence","Mus musculus",285,2349,{"v":0.03,"d":"3%"},{"v":5e-72,"d":"5.00E-72"},84.64,2020,"AK165491.1",null,"Mus musculus clone C7 LINE element sequence","Mus musculus",204,204,{"v":0,"d":"0%"},{"v":3e-47,"d":"3.00E-47"},94.7,149,"KT283012.1",{"$nulls":11},"Mus musculus MARVEL (membrane-associating) domain containing 2, mRNA (cDNA clone IMAGE:5066185), complete cds","Mus musculus",220,220,{"v":0.01,"d":"1%"},{"v":5E-53,"d":"5.00E-53"},89.6,1848,"BC049919.1",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 5, mRNA","Mus musculus",211,850,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3161,"NM_001379012.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630005C04 product:unclassifiable, full insert sequence","Mus musculus",302,2159,{"v":0.03,"d":"3%"},{"v":5e-77,"d":"5.00E-77"},87.55,2680,"AK169942.1"]
["Mus musculus clone 50 CTCF-binding site sequence","Mus musculus",102,102,{"v":0,"d":"0%"},{"v":2e-17,"d":"2.00E-17"},82.46,171,"AY457193.1",null,"Mus musculus BAC clone RP23-398K14 from 3, complete sequence","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},93.75,217058,"AC145168.5",null,"Mus musculus transgenic strain FVB/N genomic sequence","Mus musculus",268,1566,{"v":0.02,"d":"2%"},{"v":5e-67,"d":"5.00E-67"},86.4,1477,"KU665646.1",null,"Mus musculus clone 87 dsRNA sequence","Mus musculus",189,373,{"v":0,"d":"0%"},{"v":7e-43,"d":"7.00E-43"},83.66,205,"FJ041370.1",{"$nulls":11},"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830013F03 product:MARVEL (membrane-associating) domain containing 2, full insert sequence","Mus musculus",217,351,{"v":0.01,"d":"1%"},{"v":7e-52,"d":"7.00E-52"},89.53,2190,"AK156238.1",null,"Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant 6, mRNA","Mus musculus",211,740,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3098,"NM_001379013.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630014M05 product:unclassifiable, full insert sequence","Mus musculus",294,813,{"v":0.01,"d":"1%"},{"v":8e-75,"d":"8.00E-75"},89.36,2096,"AK170071.1"]
["Mus musculus transgenic strain FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J survival motor neuron protein isoform 6B (SMN2) mRNA, partial cds, alternatively spliced","Mus musculus",97.1,192,{"v":0.01,"d":"1%"},{"v":9e-16,"d":"9.00E-16"},91.43,883,"KJ780720.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Ssr2:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},93.75,37901,"JN955921.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830212P19 product:unclassifiable, full insert sequence","Mus musculus",268,1930,{"v":0.03,"d":"3%"},{"v":5e-67,"d":"5.00E-67"},88.69,3152,"AK157386.1",null,"Mus musculus BAC clone RP23-353B7 from 6, complete sequence","Mus musculus",187,358,{"v":0.01,"d":"1%"},{"v":3e-42,"d":"3.00E-42"},73.1,193668,"AC147235.3",{"$nulls":11},"Mus musculus clone 100 dsRNA sequence","Mus musculus",211,739,{"v":0.03,"d":"3%"},{"v":3e-50,"d":"3.00E-50"},82.07,256,"FJ041375.1",null,"Mus musculus mahogunin, ring finger 1, mRNA (cDNA clone MGC:61217 IMAGE:6811606), complete cds","Mus musculus",211,738,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,3165,"BC046830.1",null,"Mus musculus clone 19 dsRNA sequence","Mus musculus",289,983,{"v":0.01,"d":"1%"},{"v":4E-73,"d":"4.00E-73"},88.43,241,"FJ041342.1"]
["Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530008A19 product:hypothetical protein, full insert sequence","Mus musculus",97.1,97.1,{"v":0.01,"d":"1%"},{"v":9e-16,"d":"9.00E-16"},78.95,4959,"AK149653.1",null,"Mouse DNA sequence from clone RP23-456N11 on chromosome 2, complete sequence","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},95.45,123489,"AL929175.6",null,"Mus musculus strain 129/Sv transgenic line PWScrdel genomic sequence","Mus musculus",268,1898,{"v":0.02,"d":"2%"},{"v":5e-67,"d":"5.00E-67"},86.4,4737,"EU233428.1",null,"Mus musculus BAC clone RP23-301L2 from chromosome 6, complete sequence","Mus musculus",187,358,{"v":0.01,"d":"1%"},{"v":3e-42,"d":"3.00E-42"},73.06,196798,"AC163035.2",{"$nulls":11},"Mus musculus clone 22 dsRNA sequence","Mus musculus",195,790,{"v":0.03,"d":"3%"},{"v":3e-45,"d":"3.00E-45"},86.41,185,"FJ041343.1",null,"PREDICTED: Mus musculus mahogunin, ring finger 1 (Mgrn1), transcript variant X1, mRNA","Mus musculus",211,762,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,2469,"XM_006521837.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630208N06 product:hypothetical protein, full insert sequence","Mus musculus",289,1713,{"v":0.03,"d":"3%"},{"v":4E-73,"d":"4.00E-73"},77.65,2137,"AK155211.1"]
["Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630221F08 product:unclassifiable, full insert sequence","Mus musculus",97.1,97.1,{"v":0.01,"d":"1%"},{"v":9e-16,"d":"9.00E-16"},78.95,6620,"AK171052.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Ubqln4:tm1a(KOMP)Wtsi; transgenic","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},93.75,37970,"JN946630.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630014M05 product:unclassifiable, full insert sequence","Mus musculus",241,1320,{"v":0.02,"d":"2%"},{"v":1E-58,"d":"1.00E-58"},85.29,2096,"AK170071.1",null,"Mus musculus BAC clone RP24-147G24 from 12, complete sequence","Mus musculus",185,185,{"v":0.01,"d":"1%"},{"v":9e-42,"d":"9.00E-42"},71.76,170987,"AC147256.3",{"$nulls":11},"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630037E14 product:unclassifiable, full insert sequence","Mus musculus",183,952,{"v":0.03,"d":"3%"},{"v":7e-42,"d":"7.00E-42"},87.5,1663,"AK089204.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830155P03 product:mahogunin, ring finger 1, full insert sequence","Mus musculus",211,650,{"v":0.01,"d":"1%"},{"v":7e-50,"d":"7.00E-50"},90.12,2039,"AK153407.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530108P09 product:unclassifiable, full insert sequence","Mus musculus",272,831,{"v":0.01,"d":"1%"},{"v":4e-68,"d":"4.00E-68"},89.5,3590,"AK165488.1"]
["Mus musculus BAC clone RP23-132B15 from chromosome 8, complete sequence","Mus musculus",86.1,86.1,{"v":0,"d":"0%"},{"v":2E-12,"d":"2.00E-12"},90.77,209957,"AC158236.2",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Dtwd1:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},95.45,39519,"JN949871.1",null,"Mus musculus clone 29 dsRNA sequence","Mus musculus",233,609,{"v":0.01,"d":"1%"},{"v":2e-56,"d":"2.00E-56"},83.01,280,"FJ041345.1",null,"Mus musculus clone 1 dsRNA sequence","Mus musculus",185,185,{"v":0,"d":"0%"},{"v":9e-42,"d":"9.00E-42"},82.95,216,"FJ041333.1",{"$nulls":11},"Mus musculus transgenic Tg_GFAP-Mir183/Mir96/Mir182-Prm1 genomic sequence","Mus musculus",183,813,{"v":0.04,"d":"4%"},{"v":7e-42,"d":"7.00E-42"},79.7,3793,"JX912274.1",null,"Mus musculus clone 1 dsRNA sequence","Mus musculus",202,1147,{"v":0.02,"d":"2%"},{"v":4e-47,"d":"4.00E-47"},83.87,216,"FJ041333.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530115C12 product:unclassifiable, full insert sequence","Mus musculus",265,1675,{"v":0.02,"d":"2%"},{"v":6e-66,"d":"6.00E-66"},84.06,2020,"AK165491.1"]
["Mus musculus chromosome 8, clone RP23-171P5, complete sequence","Mus musculus",86.1,86.1,{"v":0,"d":"0%"},{"v":2E-12,"d":"2.00E-12"},90.77,242745,"AC114995.7",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Ubqln4:tm1e(KOMP)Wtsi; transgenic","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":3e-08,"d":"3.00E-08"},93.75,38024,"JN962411.1",null,"Mus musculus clone 100 dsRNA sequence","Mus musculus",233,1841,{"v":0.03,"d":"3%"},{"v":2e-56,"d":"2.00E-56"},83.2,256,"FJ041375.1",null,"Mus musculus chromosome 15, clone RP24-222C16, complete sequence","Mus musculus",180,180,{"v":0.01,"d":"1%"},{"v":4e-40,"d":"4.00E-40"},71.68,128868,"AC158750.5",{"$nulls":11},"Mus musculus clone 87 dsRNA sequence","Mus musculus",178,509,{"v":0.02,"d":"2%"},{"v":3e-40,"d":"3.00E-40"},84.13,205,"FJ041370.1",null,"Mus musculus clone 100 dsRNA sequence","Mus musculus",189,827,{"v":0.02,"d":"2%"},{"v":3E-43,"d":"3.00E-43"},80.8,256,"FJ041375.1",null,"Mus musculus transgenic strain FVB/N genomic sequence","Mus musculus",261,725,{"v":0.01,"d":"1%"},{"v":8e-65,"d":"8.00E-65"},85.21,1477,"KU665646.1"]
["Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370083M23 product:unclassifiable, full insert sequence","Mus musculus",84.2,84.2,{"v":0,"d":"0%"},{"v":7e-12,"d":"7.00E-12"},87.67,1100,"AK148303.1",null,"Mouse DNA sequence from clone DN-258P20 on chromosome 4, complete sequence","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},97.5,203649,"CU210866.8",null,"Mus musculus clone 1 dsRNA sequence","Mus musculus",231,1043,{"v":0.01,"d":"1%"},{"v":7e-56,"d":"7.00E-56"},86.73,216,"FJ041333.1",null,"Mus musculus chromosome 15, clone RP23-329G19, complete sequence","Mus musculus",180,180,{"v":0.01,"d":"1%"},{"v":4e-40,"d":"4.00E-40"},71.66,191771,"AC130477.12",{"$nulls":11},"Mus musculus clone C7 LINE element sequence","Mus musculus",174,174,{"v":0,"d":"0%"},{"v":4e-39,"d":"4.00E-39"},95.45,149,"KT283012.1",null,"Mus musculus targeted deletion, lacZ-tagged mutant allele Nudt16l1:tm1(KOMP)Ucd; transgenic","Mus musculus",183,273,{"v":0,"d":"0%"},{"v":2E-41,"d":"2.00E-41"},86.55,36785,"JN961521.1",null,"Mus musculus strain 129/Sv transgenic line PWScrdel genomic sequence","Mus musculus",261,981,{"v":0.01,"d":"1%"},{"v":8e-65,"d":"8.00E-65"},85.21,4737,"EU233428.1"]
["Mus musculus clone 47 dsRNA sequence","Mus musculus",84.2,84.2,{"v":0.01,"d":"1%"},{"v":7e-12,"d":"7.00E-12"},77.56,262,"FJ041355.1",null,"Mus musculus BAC clone RP23-345D18 from chromosome 7, complete sequence","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},93.48,189323,"AC149057.7",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630037E14 product:unclassifiable, full insert sequence","Mus musculus",220,2548,{"v":0.02,"d":"2%"},{"v":1E-52,"d":"1.00E-52"},87.89,1663,"AK089204.1",null,"Mouse DNA sequence from clone RP24-209I24 on chromosome 12, complete sequence","Mus musculus",176,314,{"v":0.01,"d":"1%"},{"v":6e-39,"d":"6.00E-39"},74.12,172025,"CU041254.6",{"$nulls":11},"Mus musculus clone 193 CTCF-binding site sequence","Mus musculus",121,236,{"v":0.01,"d":"1%"},{"v":6e-23,"d":"6.00E-23"},86.92,170,"AY457245.1",null,"Mus musculus cDNA, clone:Y1G0107K24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023159, based on BLAT search","Mus musculus",178,178,{"v":0,"d":"0%"},{"v":8e-40,"d":"8.00E-40"},93.33,201,"AK192041.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630024B09 product:unclassifiable, full insert sequence","Mus musculus",252,452,{"v":0.01,"d":"1%"},{"v":5e-62,"d":"5.00E-62"},84.79,3677,"AK154362.1"]
["Mouse DNA sequence from clone RP23-283C20 on chromosome 2, complete sequence","Mus musculus",84.2,243,{"v":0.01,"d":"1%"},{"v":7e-12,"d":"7.00E-12"},94.55,103659,"AL845520.9",null,"Mus musculus 10 BAC RP23-17L11 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},89.29,224120,"AC152983.2",null,"Mus musculus transgenic Tg_GFAP-Mir183/Mir96/Mir182-Prm1 genomic sequence","Mus musculus",215,380,{"v":0.01,"d":"1%"},{"v":7e-51,"d":"7.00E-51"},79.25,3793,"JX912274.1",null,"Mus musculus BAC clone RP23-118L13 from chromosome 12, complete sequence","Mus musculus",176,314,{"v":0.01,"d":"1%"},{"v":6e-39,"d":"6.00E-39"},74.12,218860,"AC241534.2",{"$nulls":11},"Mus musculus clone 161 CTCF-binding site sequence","Mus musculus",121,236,{"v":0.01,"d":"1%"},{"v":6e-23,"d":"6.00E-23"},86.92,169,"AY457231.1",null,"Mus musculus clone 22 dsRNA sequence","Mus musculus",172,1006,{"v":0.02,"d":"2%"},{"v":4e-38,"d":"4.00E-38"},87.01,185,"FJ041343.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830103D19 product:unclassifiable, full insert sequence","Mus musculus",246,609,{"v":0.01,"d":"1%"},{"v":2e-60,"d":"2.00E-60"},78.12,1265,"AK156850.1"]
["Mouse DNA sequence from clone RP23-396N8 on chromosome 2, complete sequence","Mus musculus",80.5,80.5,{"v":0.01,"d":"1%"},{"v":9e-11,"d":"9.00E-11"},75.63,98566,"AL928568.17",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fut1:tm1a(KOMP)Wtsi; transgenic","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},91.84,38891,"JN952415.1",null,"Mus musculus clone 87 dsRNA sequence","Mus musculus",191,548,{"v":0.01,"d":"1%"},{"v":1e-43,"d":"1.00E-43"},83.82,205,"FJ041370.1",null,"Mus musculus BAC clone RP23-390G15 from chromosome 10, complete sequence","Mus musculus",169,169,{"v":0.01,"d":"1%"},{"v":9e-37,"d":"9.00E-37"},71.41,214856,"AC127593.4",{"$nulls":11},"Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370022D09 product:unclassifiable, full insert sequence","Mus musculus",119,544,{"v":0.02,"d":"2%"},{"v":2e-22,"d":"2.00E-22"},82.27,2138,"AK148113.1",null,"Mus musculus clone 87 dsRNA sequence","Mus musculus",167,650,{"v":0.01,"d":"1%"},{"v":2e-36,"d":"2.00E-36"},81.68,205,"FJ041370.1",null,"Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530113L21 product:unclassifiable, full insert sequence","Mus musculus",239,1392,{"v":0.02,"d":"2%"},{"v":4e-58,"d":"4.00E-58"},87.92,1204,"AK144028.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Xpr1:tm1a(KOMP)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":9e-11,"d":"9.00E-11"},89.39,37974,"JN963226.1",null,"Mus musculus BAC clone RP24-354I16 from chromosome 7, complete sequence","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},91.84,202422,"AC167242.4",null,"Mus musculus clone 22 dsRNA sequence","Mus musculus",180,1207,{"v":0.02,"d":"2%"},{"v":2e-40,"d":"2.00E-40"},86.9,185,"FJ041343.1",null,"Mus musculus BAC clone CH25-265J18 from chromosome 9, complete sequence","Mus musculus",169,169,{"v":0.01,"d":"1%"},{"v":9e-37,"d":"9.00E-37"},71.58,84102,"AC242667.3",{"$nulls":11},"Mus musculus clone 50 CTCF-binding site sequence","Mus musculus",113,113,{"v":0,"d":"0%"},{"v":1e-20,"d":"1.00E-20"},84.68,171,"AY457193.1",null,"Mouse DNA sequence from clone RP23-184G6 on chromosome 11, complete sequence","Mus musculus",159,159,{"v":0,"d":"0%"},{"v":3E-34,"d":"3.00E-34"},85.91,212385,"AL645861.12",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630031M20 product:unclassifiable, full insert sequence","Mus musculus",235,1051,{"v":0.02,"d":"2%"},{"v":5e-57,"d":"5.00E-57"},85.53,1707,"AK170220.1"]
["Mus musculus chromosome 1, clone RP23-105A17, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":9e-11,"d":"9.00E-11"},89.39,179782,"AC116712.11",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fgf21:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},93.48,38092,"JN948424.1",null,"Mouse DNA sequence from clone RP24-209I24 on chromosome 12, complete sequence","Mus musculus",135,135,{"v":0.01,"d":"1%"},{"v":5e-27,"d":"5.00E-27"},73.14,172025,"CU041254.6",null,"Mus musculus BAC clone RP24-444O21 from chromosome 10, complete sequence","Mus musculus",169,169,{"v":0.01,"d":"1%"},{"v":9e-37,"d":"9.00E-37"},71.41,141420,"AC133078.3",{"$nulls":11},"Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370083M23 product:unclassifiable, full insert sequence","Mus musculus",111,205,{"v":0.01,"d":"1%"},{"v":3e-20,"d":"3.00E-20"},91.46,1100,"AK148303.1",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 9, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,3458,"NM_001405144.1",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830212P19 product:unclassifiable, full insert sequence","Mus musculus",222,942,{"v":0.01,"d":"1%"},{"v":4e-53,"d":"4.00E-53"},84.58,3152,"AK157386.1"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Gmip:tm1e(KOMP)Wtsi; transgenic","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":3E-10,"d":"3.00E-10"},94.23,39461,"JN962178.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Fgf21:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},93.48,38020,"JN948623.1",null,"Mus musculus BAC clone RP23-118L13 from chromosome 12, complete sequence","Mus musculus",135,135,{"v":0.01,"d":"1%"},{"v":5e-27,"d":"5.00E-27"},73.14,218860,"AC241534.2",null,"Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830103D19 product:unclassifiable, full insert sequence","Mus musculus",167,334,{"v":0,"d":"0%"},{"v":3e-36,"d":"3.00E-36"},80.34,1265,"AK156850.1",{"$nulls":11},"Mouse DNA sequence from clone RP23-291M22 on chromosome 4, complete sequence","Mus musculus",84.2,84.2,{"v":0,"d":"0%"},{"v":7e-12,"d":"7.00E-12"},89.55,193162,"AL670941.11",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 8, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,3518,"NM_001405143.1",null,"Mus musculus clone 1 dsRNA sequence","Mus musculus",222,618,{"v":0.01,"d":"1%"},{"v":4e-53,"d":"4.00E-53"},86.19,216,"FJ041333.1"]
["Mus musculus chromosome 8, clone RP24-373M3, complete sequence","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":3E-10,"d":"3.00E-10"},94.23,144461,"AC158564.7",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Rasip1:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},91.84,38545,"JN957840.1",null,"Mus musculus clone 47 dsRNA sequence","Mus musculus",119,481,{"v":0.01,"d":"1%"},{"v":5e-22,"d":"5.00E-22"},77.06,262,"FJ041355.1",null,"Mouse DNA sequence from clone RP23-64B4 on chromosome 11, complete sequence","Mus musculus",165,165,{"v":0,"d":"0%"},{"v":1E-35,"d":"1.00E-35"},72.22,51154,"AL645725.17",{"$nulls":11},"Mus musculus predicted gene 4707 (Gm4707) pseudogene on chromosome 17","Mus musculus",82.4,309,{"v":0.01,"d":"1%"},{"v":3E-11,"d":"3.00E-11"},94.44,1922,"NG_028543.2",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 10, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,3311,"NM_001405145.1",null,"Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530025L07 product:unclassifiable, full insert sequence","Mus musculus",217,217,{"v":0,"d":"0%"},{"v":2E-51,"d":"2.00E-51"},92.67,2026,"AK149887.1"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Lpar2:tm1e(EUCOMM)Wtsi tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":3E-10,"d":"3.00E-10"},94.23,39067,"JN956042.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rasip1:tm1e(EUCOMM)Wtsi tm2e(EUCOMM)Wtsi; transgenic","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":1e-07,"d":"1.00E-07"},91.84,38559,"JN946004.1",null,"Mouse DNA sequence from clone RP23-354G20 on chromosome 2, complete sequence","Mus musculus",115,115,{"v":0,"d":"0%"},{"v":7e-21,"d":"7.00E-21"},88,228433,"AL844842.29",null,"Mouse DNA sequence from clone RP23-141N2 on chromosome 2, complete sequence","Mus musculus",158,158,{"v":0,"d":"0%"},{"v":2e-33,"d":"2.00E-33"},71.76,206168,"AL672307.9",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Csda:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",82.4,414,{"v":0.01,"d":"1%"},{"v":3E-11,"d":"3.00E-11"},90.32,38784,"JN956491.1",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 5, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,4686,"NM_001405140.1",null,"Mus musculus clone 100 dsRNA sequence","Mus musculus",202,288,{"v":0.01,"d":"1%"},{"v":5e-47,"d":"5.00E-47"},81.35,256,"FJ041375.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Lpar2:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":3E-10,"d":"3.00E-10"},94.23,39136,"JN955793.1",null,"Mus musculus chromosome 18, clone RP23-37O16, complete sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,186860,"AC161511.3",null,"Mus musculus chromosome 3, clone RP24-93G19, complete sequence","Mus musculus",104,104,{"v":0,"d":"0%"},{"v":1e-17,"d":"1.00E-17"},92.11,208878,"AC118591.7",null,"Mouse DNA sequence from clone RP24-69K11 on chromosome X, complete sequence","Mus musculus",158,158,{"v":0.01,"d":"1%"},{"v":2e-33,"d":"2.00E-33"},71.28,88912,"BX088729.7",{"$nulls":11},"Mus musculus chromosome 17, clone RP23-103F2, complete sequence","Mus musculus",82.4,309,{"v":0.01,"d":"1%"},{"v":3E-11,"d":"3.00E-11"},94.44,208198,"AC107664.8",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 6, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,4578,"NM_001405141.1",null,"Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230106P21 product:unclassifiable, full insert sequence","Mus musculus",165,165,{"v":0,"d":"0%"},{"v":7e-36,"d":"7.00E-36"},80.16,1174,"AK039199.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Gmip:tm1a(KOMP)Wtsi; transgenic","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":3E-10,"d":"3.00E-10"},94.23,39448,"JN946397.1",null,"Mus musculus BAC clone RP24-262O15 from chromosome 16, complete sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},97.44,173200,"AC154654.2",null,"Mouse DNA sequence from clone RP23-330I16 on chromosome X, complete sequence","Mus musculus",97.1,168,{"v":0,"d":"0%"},{"v":2e-15,"d":"2.00E-15"},87.95,203422,"AL713863.7",null,"Mus musculus BAC clone RP24-326C5 from chromosome y, complete sequence","Mus musculus",128,128,{"v":0,"d":"0%"},{"v":2e-24,"d":"2.00E-24"},70.97,155993,"AC194787.4",{"$nulls":11},"Mouse DNA sequence from clone DN-10I6 on chromosome 1, complete sequence","Mus musculus",82.4,290,{"v":0.01,"d":"1%"},{"v":3E-11,"d":"3.00E-11"},87.01,147389,"CU407006.6",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 2, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,4627,"NM_001405137.1",null,"Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370022D09 product:unclassifiable, full insert sequence","Mus musculus",152,152,{"v":0,"d":"0%"},{"v":5e-32,"d":"5.00E-32"},84.42,2138,"AK148113.1"]
["Mus musculus lysophosphatidic acid receptor LPA2 (Edg4) gene, complete cds","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":3E-10,"d":"3.00E-10"},94.23,5618,"AF218844.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Polr2d:tm1e(KOMP)Wtsi; transgenic","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,38059,"JN956481.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Lipc:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",93.5,252,{"v":0,"d":"0%"},{"v":3e-14,"d":"3.00E-14"},86.36,39567,"JN964003.1",null,"Mus musculus BAC clone RP24-146P3 from chromosome y, complete sequence","Mus musculus",128,128,{"v":0,"d":"0%"},{"v":2e-24,"d":"2.00E-24"},70.97,57169,"AC191597.2",{"$nulls":11},"Mus musculus BAC clone RP23-42J4 from 6, complete sequence","Mus musculus",82.4,414,{"v":0.01,"d":"1%"},{"v":3E-11,"d":"3.00E-11"},90.32,250147,"AC122191.4",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 4, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,4689,"NM_001405139.1",null,"Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630037E14 product:unclassifiable, full insert sequence","Mus musculus",145,383,{"v":0.01,"d":"1%"},{"v":8e-30,"d":"8.00E-30"},83.12,1663,"AK089204.1"]
["Mus musculus BAC clone RP23-345D18 from chromosome 7, complete sequence","Mus musculus",76.8,277,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94,189323,"AC149057.7",null,"Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610028L19 product:RIKEN cDNA 2610028L19 gene (DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE, EC 2.7.7.6), full insert sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,958,"AK011600.1",null,"Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370083M23 product:unclassifiable, full insert sequence","Mus musculus",93.5,93.5,{"v":0,"d":"0%"},{"v":3e-14,"d":"3.00E-14"},86.9,1100,"AK148303.1",null,"Mouse DNA sequence from clone RP23-20A22 on chromosome 13, complete sequence","Mus musculus",126,126,{"v":0,"d":"0%"},{"v":6e-24,"d":"6.00E-24"},78.53,184504,"AL627326.16",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Rnaset2b:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},92.86,38251,"JN952331.1",null,"Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130073L17 product:hypothetical protein, full insert sequence","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,1906,"AK038042.1",null,"Mus musculus adult male brain cDNA, RIKEN full-length enriched library, clone:0710005I21 product:unclassifiable, full insert sequence","Mus musculus",128,128,{"v":0,"d":"0%"},{"v":9e-25,"d":"9.00E-25"},86.84,326,"AK002995.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fut1:tm1a(KOMP)Wtsi; transgenic","Mus musculus",76.8,277,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94,38891,"JN952415.1",null,"Mouse DNA sequence from clone RP23-193B21 on chromosome 16, complete sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},97.44,208110,"CT010576.9",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Lipc:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",93.5,252,{"v":0,"d":"0%"},{"v":3e-14,"d":"3.00E-14"},86.36,39518,"JN955199.1",null,"Mouse DNA sequence from clone RP23-38L5 on chromosome 13, complete sequence","Mus musculus",122,122,{"v":0,"d":"0%"},{"v":7e-23,"d":"7.00E-23"},72.31,199424,"CT030187.7",{"$nulls":11},"Mus musculus targeted deletion, lacZ-tagged mutant allele 2810405K02Rik:tm1(KOMP)Ucd; transgenic","Mus musculus",80.5,294,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},90.32,37222,"JN961483.1",null,"Mus musculus ring finger protein 157, mRNA (cDNA clone IMAGE:6401088)","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,4436,"BC053070.1",null,"Mus musculus clone 87 dsRNA sequence","Mus musculus",121,229,{"v":0,"d":"0%"},{"v":1E-22,"d":"1.00E-22"},79.43,205,"FJ041370.1"]
["Mus musculus BAC clone RP24-354I16 from chromosome 7, complete sequence","Mus musculus",76.8,277,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94,202422,"AC167242.4",null,"Mus musculus polymerase (RNA) II (DNA directed) polypeptide D (Polr2d), transcript variant 1, mRNA","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,1074,"NM_027002.4",null,"Mus musculus chromosome 15, clone RP23-74H8, complete sequence","Mus musculus",91.6,91.6,{"v":0,"d":"0%"},{"v":1E-13,"d":"1.00E-13"},94.83,246325,"AC104225.18",null,"Mouse DNA sequence from clone RP24-125H1 on chromosome 13, complete sequence","Mus musculus",122,122,{"v":0,"d":"0%"},{"v":7e-23,"d":"7.00E-23"},72.31,86103,"CT033784.5",{"$nulls":11},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Gmip:tm1e(KOMP)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},88.41,39461,"JN962178.1",null,"Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:C920006G23 product:weakly similar to 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610042J20 product:hypothetical crystallin/RING finger containing protein, full insert sequence (Hypothetical crystallin/RING finger containing protein) (Mahogunin, ring finger 1) [Mus musculus], full insert sequence","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,1996,"AK169566.1",null,"Mus musculus transgenic Tg_GFAP-Mir183/Mir96/Mir182-Prm1 genomic sequence","Mus musculus",119,205,{"v":0.01,"d":"1%"},{"v":5e-22,"d":"5.00E-22"},74.22,3793,"JX912274.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fgf21:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",76.8,277,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94,38092,"JN948424.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Polr2d:tm1a(KOMP)Wtsi; transgenic","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,38076,"JN949873.1",null,"Mouse DNA sequence from clone RP24-82E11 on chromosome 9, complete sequence","Mus musculus",91.6,91.6,{"v":0,"d":"0%"},{"v":1E-13,"d":"1.00E-13"},84.21,211707,"CT030644.8",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Grxcr1:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",117,117,{"v":0,"d":"0%"},{"v":3e-21,"d":"3.00E-21"},77.93,38114,"JN955796.1",{"$nulls":11},"Mus musculus chromosome 8, clone RP24-373M3, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},88.41,144461,"AC158564.7",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 3, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,4749,"NM_001405138.1",null,"Mus musculus clone 193 CTCF-binding site sequence","Mus musculus",113,113,{"v":0,"d":"0%"},{"v":2e-20,"d":"2.00E-20"},86.54,170,"AY457245.1"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Fgf21:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",76.8,277,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94,38020,"JN948623.1",null,"Mus musculus polymerase (RNA) II (DNA directed) polypeptide D, mRNA (cDNA clone MGC:8083 IMAGE:3588284), complete cds","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,1027,"BC004810.1",null,"Mus musculus BAC clone RP24-80J11 from chromosome 9, complete sequence","Mus musculus",91.6,91.6,{"v":0,"d":"0%"},{"v":1E-13,"d":"1.00E-13"},84.21,226770,"AC159890.2",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Grxcr1:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",117,117,{"v":0,"d":"0%"},{"v":3e-21,"d":"3.00E-21"},77.93,38106,"JN962910.1",{"$nulls":11},"Mus musculus BAC clone RP23-345D18 from chromosome 7, complete sequence","Mus musculus",80.5,228,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},86.84,189323,"AC149057.7",null,"Mus musculus ring finger protein 157 (Rnf157), transcript variant 1, mRNA","Mus musculus",154,154,{"v":0,"d":"0%"},{"v":1e-32,"d":"1.00E-32"},86.01,4648,"NM_027258.2",null,"Mus musculus clone 161 CTCF-binding site sequence","Mus musculus",113,113,{"v":0,"d":"0%"},{"v":2e-20,"d":"2.00E-20"},86.54,169,"AY457231.1"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Rasip1:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",76.8,277,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94,38545,"JN957840.1",null,"Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310002G05 product:DNA-DIRECTED RNA POLYMERASE II 16 KDA POLYPEPTIDE (EC 2.7.7.6) (RPB4) homolog [Homo sapiens], full insert sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,1020,"AK009093.1",null,"Mus musculus chromosome 15, clone RP24-299A13, complete sequence","Mus musculus",91.6,91.6,{"v":0,"d":"0%"},{"v":1E-13,"d":"1.00E-13"},94.83,165791,"AC161206.10",null,"Mus musculus chromosome 15, clone RP23-408O11, complete sequence","Mus musculus",110,110,{"v":0,"d":"0%"},{"v":6e-19,"d":"6.00E-19"},72.43,201092,"AC099614.9",{"$nulls":11},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Lpar2:tm1e(EUCOMM)Wtsi tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},88.41,39067,"JN956042.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Fam100a:tm1e(KOMP)Wtsi; transgenic","Mus musculus",150,150,{"v":0,"d":"0%"},{"v":2e-31,"d":"2.00E-31"},93.14,38739,"JN952268.1",null,"Mus musculus clone 18 dsRNA sequence","Mus musculus",108,108,{"v":0,"d":"0%"},{"v":1e-18,"d":"1.00E-18"},84.35,159,"FJ041341.1"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rasip1:tm1e(EUCOMM)Wtsi tm2e(EUCOMM)Wtsi; transgenic","Mus musculus",76.8,277,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94,38559,"JN946004.1",null,"Mus musculus polymerase (RNA) II (DNA directed) polypeptide D (Polr2d), transcript variant 3, mRNA","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,978,"NM_001357480.1",null,"Mus musculus mRNA for mKIAA1483 protein","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},91.04,6794,"AK173184.1",null,"Mus musculus strain 129S6/SvEvTac clone rp22-121i21 map 11, complete sequence","Mus musculus",100,100,{"v":0,"d":"0%"},{"v":4e-16,"d":"4.00E-16"},76.8,168186,"AC119420.12",{"$nulls":11},"Mus musculus BAC clone RP24-484L12 from chromosome 17, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},92.86,192097,"AC168980.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fam100a:tm1a(KOMP)Wtsi; transgenic","Mus musculus",150,150,{"v":0,"d":"0%"},{"v":2e-31,"d":"2.00E-31"},93.14,38799,"JN949860.1",null,"Mus musculus clone 50 CTCF-binding site sequence","Mus musculus",106,106,{"v":0,"d":"0%"},{"v":4e-18,"d":"4.00E-18"},84.62,171,"AY457193.1"]
["Mouse DNA sequence from clone RP23-456N11 on chromosome 2, complete sequence","Mus musculus",73.1,275,{"v":0.01,"d":"1%"},{"v":1E-8,"d":"1.00E-08"},97.62,123489,"AL929175.6",null,"Mus musculus BAC clone RP24-331E1 from chromosome 18, complete sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":4e-07,"d":"4.00E-07"},90.38,171769,"AC124393.5",null,"Mus musculus BAC clone RP23-257K20 from 10, complete sequence","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},91.04,177430,"AC117205.3",null,"Mouse DNA sequence from clone DN-11O12 on chromosome 11, complete sequence","Mus musculus",100,100,{"v":0,"d":"0%"},{"v":4e-16,"d":"4.00E-16"},76.47,154996,"CU207341.13",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Lpar2:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},88.41,39136,"JN955793.1",null,"Mus musculus cDNA, clone:Y2G0123D09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023159, based on BLAT search","Mus musculus",117,117,{"v":0,"d":"0%"},{"v":2e-21,"d":"2.00E-21"},91.67,166,"AK211892.1",null,"Mus musculus transgenic strain FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J survival motor neuron protein isoform 6B (SMN2) mRNA, partial cds, alternatively spliced","Mus musculus",97.1,97.1,{"v":0,"d":"0%"},{"v":2e-15,"d":"2.00E-15"},91.43,883,"KJ780720.1"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Dtwd1:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",73.1,275,{"v":0.01,"d":"1%"},{"v":1E-8,"d":"1.00E-08"},97.62,39519,"JN949871.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Arhgap23:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",63.9,63.9,{"v":0,"d":"0%"},{"v":6e-06,"d":"6.00E-06"},93.18,38688,"JN959094.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Zbtb2:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},91.04,40691,"JN952338.1",null,"Mouse DNA sequence from clone RP23-221M24 on chromosome 11, complete sequence","Mus musculus",100,100,{"v":0,"d":"0%"},{"v":4e-16,"d":"4.00E-16"},76.47,109397,"AL611937.6",{"$nulls":11},"Mouse DNA sequence from clone RP23-15L19 on chromosome 4, complete sequence","Mus musculus",80.5,294,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},88.41,136416,"AL607032.16",null,"Mus musculus clone 193 CTCF-binding site sequence","Mus musculus",117,229,{"v":0,"d":"0%"},{"v":2e-21,"d":"2.00E-21"},87.25,170,"AY457245.1",null,"Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370083M23 product:unclassifiable, full insert sequence","Mus musculus",93.5,159,{"v":0,"d":"0%"},{"v":3e-14,"d":"3.00E-14"},90.14,1100,"AK148303.1"]
["Mus musculus chromosome 9, clone RP23-174F7, complete sequence","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":5e-08,"d":"5.00E-08"},90.74,230293,"AC112676.8",null,"Mouse DNA sequence from clone RP23-157O10 on chromosome 11, complete sequence","Mus musculus",63.9,63.9,{"v":0,"d":"0%"},{"v":6e-06,"d":"6.00E-06"},93.18,233204,"AL596088.14",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Zbtb2:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},91.04,40689,"JN948075.1",null,"Mus musculus STARR-seq mESC enhancer starr_04962 (LOC131297731) on chromosome 2","Mus musculus",93.5,93.5,{"v":0,"d":"0%"},{"v":6e-14,"d":"6.00E-14"},76.06,2150,"NG_206143.1",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fut1:tm1a(KOMP)Wtsi; transgenic","Mus musculus",80.5,228,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},86.84,38891,"JN952415.1",null,"Mus musculus clone 161 CTCF-binding site sequence","Mus musculus",117,229,{"v":0,"d":"0%"},{"v":2e-21,"d":"2.00E-21"},87.25,169,"AY457231.1",null,"Mouse DNA sequence from clone RP23-176N9 on chromosome 2, complete sequence","Mus musculus",93.5,93.5,{"v":0,"d":"0%"},{"v":3e-14,"d":"3.00E-14"},92.42,194864,"AL691489.21"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fam96a:tm2a(EUCOMM)Wtsi tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":5e-08,"d":"5.00E-08"},90.74,37860,"JN957735.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Arhgap23:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",63.9,63.9,{"v":0,"d":"0%"},{"v":6e-06,"d":"6.00E-06"},93.18,38712,"JN959095.1",null,"Mus musculus chromosome 6, clone RP24-170E4, complete sequence","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},88.31,190612,"AC118212.7",null,"Mouse DNA sequence from clone RP23-143O19 on chromosome 2, complete sequence","Mus musculus",93.5,93.5,{"v":0,"d":"0%"},{"v":6e-14,"d":"6.00E-14"},76.06,207403,"AL772188.8",{"$nulls":11},"Mus musculus BAC clone RP24-354I16 from chromosome 7, complete sequence","Mus musculus",80.5,228,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},86.84,202422,"AC167242.4",null,"Mus musculus cDNA, clone:Y0G0107D24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",111,111,{"v":0,"d":"0%"},{"v":8e-20,"d":"8.00E-20"},96.97,222,"AK178579.1",null,"Mus musculus clone 47 dsRNA sequence","Mus musculus",91.6,151,{"v":0,"d":"0%"},{"v":1E-13,"d":"1.00E-13"},80.47,262,"FJ041355.1"]
["Mus musculus BAC clone RP24-261N14 from chromosome 9, complete sequence","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":5e-08,"d":"5.00E-08"},90.74,162530,"AC124439.4",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Acacb:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},92.86,37970,"JN962344.1",null,"Mus musculus targeted deletion, lacZ-tagged mutant allele BC030867:tm1(KOMP)Wtsi; transgenic","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},87.34,37222,"JN950664.1",null,"Mouse DNA sequence from clone RP23-94I24 on chromosome X, complete sequence","Mus musculus",91.6,91.6,{"v":0,"d":"0%"},{"v":2e-13,"d":"2.00E-13"},88.16,184898,"AL683822.8",{"$nulls":11},"Mus musculus BAC clone RP23-46B12 from chromosome 9, complete sequence","Mus musculus",80.5,153,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},89.06,213408,"AC163666.2",null,"Mus musculus cDNA, clone:Y0G0112B08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",111,111,{"v":0,"d":"0%"},{"v":8e-20,"d":"8.00E-20"},96.97,223,"AK179898.1",null,"Mouse DNA sequence from clone RP23-81G14 on chromosome 11, complete sequence","Mus musculus",86.1,153,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},86.25,228391,"AL596331.15"]
["Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830022I15 product:sorting nexin 1, full insert sequence","Mus musculus",71.3,71.3,{"v":0,"d":"0%"},{"v":5e-08,"d":"5.00E-08"},92.16,3636,"AK171966.1",null,"Mus musculus chromosome 9, clone RP24-308L17, complete sequence","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},91.3,138507,"AC120390.12",null,"Mouse DNA sequence from clone RP23-461C4 on chromosome 11, complete sequence","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},87.34,193721,"AL954730.15",null,"Mouse DNA sequence from clone RP23-47A2 on chromosome 13 Contains part of a novel gene (6620401C13Rik, complete sequence","Mus musculus",86.1,86.1,{"v":0,"d":"0%"},{"v":1e-11,"d":"1.00E-11"},96.23,199848,"AL512647.14",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Fgf21:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",80.5,228,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},86.84,38092,"JN948424.1",null,"Mus musculus cDNA, clone:Y0G0101M10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",111,111,{"v":0,"d":"0%"},{"v":8e-20,"d":"8.00E-20"},96.97,222,"AK177150.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Prdm4:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",84.2,84.2,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},93.1,39215,"JN954025.1"]
["Mus musculus chromosome 8, clone RP24-487J5, complete sequence","Mus musculus",69.4,197,{"v":0.01,"d":"1%"},{"v":2e-07,"d":"2.00E-07"},87.93,163170,"AC115914.6",null,"Mus musculus strain 129/Sv transgenic line PWScrdel genomic sequence","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},97.22,4737,"EU233428.1",null,"Mus musculus BAC clone RP23-193O18 from chromosome 18, complete sequence","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},89.04,220193,"AC131713.3",null,"Mus musculus BAC clone RP23-46B12 from chromosome 9, complete sequence","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},85.9,213408,"AC163666.2",{"$nulls":11},"Mus musculus targeted deletion, lacZ-tagged mutant allele Rnaset2a:tm1(KOMP)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},92.86,37222,"JN961631.1",null,"Mus musculus cDNA, clone:Y0G0112E17, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",111,111,{"v":0,"d":"0%"},{"v":8e-20,"d":"8.00E-20"},96.97,278,"AK179943.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Prdm4:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",84.2,84.2,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},93.1,39234,"JN950060.1"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Tmem170:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",69.4,197,{"v":0.01,"d":"1%"},{"v":2e-07,"d":"2.00E-07"},87.93,37985,"JN960865.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Acacb:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},92.86,37979,"JN947690.1",null,"Mouse DNA sequence from clone RP23-335A19 on chromosome 3, complete sequence","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},81.65,207366,"AL606750.13",null,"Mouse DNA sequence from clone RP24-225E17 on chromosome 4, complete sequence","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},81.63,28163,"AL929431.15",{"$nulls":11},"Mouse DNA sequence from clone RP23-399H17 on chromosome 4, complete sequence","Mus musculus",80.5,146,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},87.5,201590,"AL844182.10",null,"Mus musculus cDNA, clone:Y2G0131G06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",111,111,{"v":0,"d":"0%"},{"v":8e-20,"d":"8.00E-20"},96.97,227,"AK214313.1",null,"Mus musculus BAC clone RP23-271E15 from chromosome 10, complete sequence","Mus musculus",84.2,84.2,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},93.1,182748,"AC151901.3"]
["Mouse DNA sequence from clone RP23-123O10 on chromosome 11, complete sequence","Mus musculus",69.4,69.4,{"v":0,"d":"0%"},{"v":2e-07,"d":"2.00E-07"},90.57,187803,"AL596252.11",null,"Mus musculus chromosome 5, clone RP24-67M11, complete sequence","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},91.11,167898,"AC102677.9",null,"Mus musculus BAC clone RP23-294G5 from chromosome 18, complete sequence","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},89.04,229447,"AC132421.4",null,"Mouse DNA sequence from clone RP24-286H7 on chromosome 9, complete sequence","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},85.9,148870,"CT025673.8",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Gmip:tm1a(KOMP)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},88.41,39448,"JN946397.1",null,"Mus musculus adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330156J07 product:mahogunin, ring finger 1, full insert sequence","Mus musculus",111,111,{"v":0,"d":"0%"},{"v":8e-20,"d":"8.00E-20"},96.97,1570,"AK034100.1",null,"Mus musculus BAC clone RP23-30C12 from 10, complete sequence","Mus musculus",84.2,84.2,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},93.1,221920,"AC122919.3"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Tmem170:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",69.4,197,{"v":0.01,"d":"1%"},{"v":2e-07,"d":"2.00E-07"},87.93,38036,"JN945060.1",null,"Mus musculus targeted deletion, lacZ-tagged mutant allele Ppp2r3a:tm1(KOMP)Ucd tm1(KOMP)Wtsi; transgenic","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},91.3,37222,"JN946780.1",null,"Mouse DNA sequence from clone DN-384L23 on chromosome 3, complete sequence","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},81.65,177135,"AL663099.7",null,"Mus musculus predicted gene 4707 (Gm4707) pseudogene on chromosome 17","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":5e-10,"d":"5.00E-10"},96,1922,"NG_028543.2",{"$nulls":11},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rnaset2b:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},92.86,38185,"JN960485.1",null,"Mus musculus cDNA, clone:Y1G0111P15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",111,111,{"v":0,"d":"0%"},{"v":8e-20,"d":"8.00E-20"},96.97,222,"AK193360.1",null,"Genomic sequence for Mus musculus, clone RP23-105K11, complete sequence","Mus musculus",84.2,84.2,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},93.1,222520,"AC063968.5"]
["Mus musculus BAC clone RP23-218F21 from chromosome 8, complete sequence","Mus musculus",69.4,197,{"v":0.01,"d":"1%"},{"v":2e-07,"d":"2.00E-07"},87.93,207577,"AC127315.4",null,"Mouse DNA sequence from clone RP23-393E22 on chromosome 16, complete sequence","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},97.3,220149,"CT025520.10",null,"Mus musculus STARR-seq mESC enhancer starr_08495 (LOC131338597) on chromosome 3","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},81.65,1575,"NG_208158.1",null,"Mus musculus chromosome 7, clone RP23-124B2, complete sequence","Mus musculus",80.5,140,{"v":0,"d":"0%"},{"v":5e-10,"d":"5.00E-10"},78.74,211123,"AC023248.20",{"$nulls":11},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Fgf21:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",80.5,228,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},86.84,38020,"JN948623.1",null,"Mus musculus clone 50 CTCF-binding site sequence","Mus musculus",110,214,{"v":0,"d":"0%"},{"v":3e-19,"d":"3.00E-19"},85.29,171,"AY457193.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Csda:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",82.4,221,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},94.34,38784,"JN956491.1"]
["Mus musculus transmembrane protein 170 (Tmem170), transcript variant 1, mRNA","Mus musculus",69.4,197,{"v":0.01,"d":"1%"},{"v":2e-07,"d":"2.00E-07"},87.93,3845,"NM_025781.3",null,"Mus musculus BAC clone RP23-240B12 from chromosome 5, complete sequence","Mus musculus",62.1,62.1,{"v":0,"d":"0%"},{"v":2e-05,"d":"2.00E-05"},92.86,227388,"AC122282.5",null,"Mouse DNA sequence from clone RP23-13I22 on chromosome 11, complete sequence","Mus musculus",86.1,86.1,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},91.94,58200,"AL645850.6",null,"Mus musculus partial Kcnq1 gene for potassium channel protein and associated 187740 bp genomic fragment","Mus musculus domesticus",80.5,140,{"v":0,"d":"0%"},{"v":5e-10,"d":"5.00E-10"},78.74,187740,"AJ271885.2",{"$nulls":11},"Mouse DNA sequence from clone RP24-286H7 on chromosome 9, complete sequence","Mus musculus",80.5,153,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},89.06,148870,"CT025673.8",null,"Mus musculus cDNA, clone:Y0G0107J01, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",106,106,{"v":0,"d":"0%"},{"v":4e-18,"d":"4.00E-18"},94.2,223,"AK178682.1",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Tmed8:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},96,37908,"JN956282.1"]
["Mus musculus chromosome 2, clone RPCI-22-255I01 and RPCI-22-91F12 strain 129/Sv, complete sequence","Mus musculus",69.4,195,{"v":0,"d":"0%"},{"v":2e-07,"d":"2.00E-07"},97.5,122877,"CR932797.1",null,"Mus musculus BAC clone RP23-274I8 from chromosome 1, complete sequence","Mus musculus",60.2,60.2,{"v":0,"d":"0%"},{"v":7e-05,"d":"7.00E-05"},97.14,225058,"AC124547.4",null,"Mus musculus distal-less homeo box 7 (Dlx7) and distal-less homeo box 3 (Dlx3) genes, complete cds","Mus musculus",86.1,86.1,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},91.94,78651,"AF452637.1",null,"Mouse DNA sequence from clone RP23-456N11 on chromosome 2, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":5e-10,"d":"5.00E-10"},92.73,123489,"AL929175.6",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Rasip1:tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,228,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},86.84,38545,"JN957840.1",null,"Mus musculus cDNA, clone:Y2G0121P21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",102,102,{"v":0,"d":"0%"},{"v":5e-17,"d":"5.00E-17"},94.12,209,"AK211507.1",null,"Mouse DNA sequence from clone CH29-607J18 on chromosome 6, complete sequence","Mus musculus",82.4,149,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},91.67,187081,"CU207334.6"]
["Mouse DNA sequence from clone RP23-333P17 on chromosome 2, complete sequence","Mus musculus",69.4,195,{"v":0,"d":"0%"},{"v":2e-07,"d":"2.00E-07"},97.5,154074,"AL928572.5",null,"Mouse DNA sequence from clone RP23-247I20 on chromosome 4, complete sequence","Mus musculus",60.2,60.2,{"v":0,"d":"0%"},{"v":7e-05,"d":"7.00E-05"},87.04,188633,"AL606932.10",null,"Mus musculus BAC clone RP23-46B12 from chromosome 9, complete sequence","Mus musculus",86.1,168,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},90.62,213408,"AC163666.2",null,"Mus musculus genomic DNA, chromosome 7, clone:B96, complete sequence","Mus musculus",80.5,140,{"v":0,"d":"0%"},{"v":5e-10,"d":"5.00E-10"},78.74,191373,"AP001295.1",{"$nulls":11},"Mus musculus BAC clone RP24-148B13 from 17, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},92.86,172633,"AC122413.4",null,"Mus musculus cDNA, clone:Y1G0135C09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070658, based on BLAT search","Mus musculus",100,100,{"v":0,"d":"0%"},{"v":2E-16,"d":"2.00E-16"},93.94,222,"AK200602.1",null,"Mus musculus BAC clone RP23-351O8 from 12, complete sequence","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},94.34,200045,"AC132609.3"]
["Mus musculus adult male colon cDNA, RIKEN full-length enriched library, clone:9030409E16 product:RIKEN cDNA 9030409E16 gene, full insert sequence","Mus musculus",69.4,197,{"v":0.01,"d":"1%"},{"v":2e-07,"d":"2.00E-07"},87.93,1944,"AK018496.1",null,"Mus musculus BAC clone RP23-433L22 from 8, complete sequence","Mus musculus",60.2,60.2,{"v":0,"d":"0%"},{"v":7e-05,"d":"7.00E-05"},94.87,182152,"AC147616.3",null,"Mus musculus BAC clone RP23-39N24 from 15, complete sequence","Mus musculus",86.1,86.1,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},90.77,203855,"AC122900.3",null,"Mus musculus chromosome 17, clone RP23-103F2, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":5e-10,"d":"5.00E-10"},96,208198,"AC107664.8",{"$nulls":11},"Mus musculus lysophosphatidic acid receptor LPA2 (Edg4) gene, complete cds","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":1E-10,"d":"1.00E-10"},88.41,5618,"AF218844.1",null,"Mouse DNA sequence from clone RP23-64F17 on chromosome 4, complete sequence","Mus musculus",91.6,161,{"v":0,"d":"0%"},{"v":1E-13,"d":"1.00E-13"},93.55,223133,"AL683829.15",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Tmed8:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},96,37964,"JN948643.1"]
["Mus musculus transmembrane protein 170 (Tmem170), transcript variant 2, mRNA","Mus musculus",69.4,197,{"v":0.01,"d":"1%"},{"v":2e-07,"d":"2.00E-07"},87.93,3776,"NM_001442530.1",null,"Mus musculus chromosome 5, clone RP23-377E6, complete sequence","Mus musculus",60.2,60.2,{"v":0,"d":"0%"},{"v":7e-05,"d":"7.00E-05"},92.68,194045,"AC121298.10",null,"Mouse DNA sequence from clone RP24-286H7 on chromosome 9, complete sequence","Mus musculus",86.1,168,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},90.62,148870,"CT025673.8",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Dtwd1:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":5e-10,"d":"5.00E-10"},92.73,39519,"JN949871.1",{"$nulls":11},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rasip1:tm1e(EUCOMM)Wtsi tm2e(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,228,{"v":0.01,"d":"1%"},{"v":1E-10,"d":"1.00E-10"},86.84,38559,"JN946004.1",null,"Mus musculus cDNA, clone:Y0G0117K01, strand:unspecified","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},84.78,422,"AK181299.1",null,"Mus musculus BAC clone RP24-235L23 from chromosome 12, complete sequence","Mus musculus",82.4,82.4,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},94.34,184240,"AC151967.6"]
["Mus musculus chromosome 2, clone RPCI-21-331C08 strain 129/Sv, complete sequence","Mus musculus",69.4,195,{"v":0,"d":"0%"},{"v":2e-07,"d":"2.00E-07"},97.5,107646,"CR932801.1",null,"Mus musculus BAC clone RP23-36C8 from 1, complete sequence","Mus musculus",60.2,60.2,{"v":0,"d":"0%"},{"v":7e-05,"d":"7.00E-05"},97.14,247309,"AC122189.4",null,"Mus musculus chromosome 8, clone RP23-23D6, complete sequence","Mus musculus",84.2,422,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},96.15,185866,"AC109510.7",null,"Mus musculus, clone RP23-279K17, complete sequence","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":2e-09,"d":"2.00E-09"},79.65,174802,"AC101711.7",{"$nulls":11},"Mus musculus BAC clone RP23-364E18 from 5, complete sequence","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":3E-10,"d":"3.00E-10"},90.32,190505,"AC125048.2",null,"Mus musculus cDNA, clone:Y0G0126J06, strand:unspecified","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},84.78,424,"AK183627.1",null,"Mus musculus BAC clone RP23-355N5 from chromosome 6, complete sequence","Mus musculus",82.4,149,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},91.67,171747,"AC132412.2"]
["Mus musculus 10 BAC RP23-17L11 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":7e-07,"d":"7.00E-07"},87.93,224120,"AC152983.2",null,"Mus musculus 6 BAC RP24-441P8 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence","Mus musculus",60.2,60.2,{"v":0,"d":"0%"},{"v":7e-05,"d":"7.00E-05"},91.11,196288,"AC155838.7",null,"Mouse DNA sequence from clone RP23-81G14 on chromosome 11, complete sequence","Mus musculus",84.2,226,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},90.62,228391,"AL596331.15",null,"Mus musculus chromosome 14, clone RP23-450N9, complete sequence","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":2e-09,"d":"2.00E-09"},79.65,201436,"AC131920.7",{"$nulls":11},"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Foxj2:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",76.8,76.8,{"v":0,"d":"0%"},{"v":1e-09,"d":"1.00E-09"},94,38770,"JN959657.1",null,"Mus musculus cDNA, clone:Y0G0112D24, strand:unspecified","Mus musculus",89.8,89.8,{"v":0,"d":"0%"},{"v":4e-13,"d":"4.00E-13"},84.78,438,"AK179931.1",null,"Mus musculus BAC clone RP23-42J4 from 6, complete sequence","Mus musculus",82.4,221,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},92.86,250147,"AC122191.4"]
["Mus musculus 10 BAC RP24-293I2 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence","Mus musculus",67.6,191,{"v":0,"d":"0%"},{"v":7e-07,"d":"7.00E-07"},95.24,199258,"AC159503.10",null,"Mus musculus 6 BAC RP24-462N21 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence","Mus musculus",58.4,58.4,{"v":0,"d":"0%"},{"v":0.0003,"d":"3.00E-04"},100,152279,"AC155915.2",null,"Mus musculus chromosome 8, clone RP23-338K3, complete sequence","Mus musculus",84.2,422,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},96.15,213363,"AC164399.4",null,"Mouse DNA sequence from clone RP23-8O24 on chromosome 4, complete sequence","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":2e-09,"d":"2.00E-09"},90,109835,"AL772139.9",{"$nulls":11},"Mus musculus chromosome 8, clone RP23-23D6, complete sequence","Mus musculus",76.8,337,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94.12,185866,"AC109510.7",null,"Mus musculus strain B6.C3H LTR repeat regions; and mutant mahoganoid (md) gene, partial sequence","Mus musculus",87.9,87.9,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},83.67,1612,"AH012208.2",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Dok3:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},92.86,39205,"JN956307.1"]
["Mus musculus BAC clone RP23-153F8 from 16, complete sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":7e-07,"d":"7.00E-07"},95.24,195017,"AC154667.2",null,"Mus musculus 6 BAC RP24-365C10 (Roswell Park Cancer Institute (C57BL/6J Male) Mouse BAC Library) complete sequence","Mus musculus",58.4,58.4,{"v":0,"d":"0%"},{"v":0.0003,"d":"3.00E-04"},100,172981,"AC154020.3",null,"Mus musculus chromosome 8, clone RP23-73E9, complete sequence","Mus musculus",84.2,422,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},96.15,225655,"AC099690.8",null,"Mus musculus BAC clone RP23-315K10 from chromosome 13, complete sequence","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":2e-09,"d":"2.00E-09"},83.33,165570,"AC156569.3",{"$nulls":11},"Mus musculus chromosome 1, clone RP23-244H18, complete sequence","Mus musculus",76.8,270,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},85.71,173113,"AC101699.9",null,"Mouse DNA sequence from clone RP23-81G14 on chromosome 11, complete sequence","Mus musculus",87.9,162,{"v":0,"d":"0%"},{"v":1e-12,"d":"1.00E-12"},92.06,228391,"AL596331.15",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Dok3:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},92.86,39162,"JN960477.1"]
["Mouse DNA sequence from clone RP23-399H17 on chromosome 4, complete sequence","Mus musculus",67.6,67.6,{"v":0,"d":"0%"},{"v":7e-07,"d":"7.00E-07"},97.5,201590,"AL844182.10",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Noc3l:tm1a(KOMP)Wtsi; transgenic","Mus musculus",56.5,56.5,{"v":0,"d":"0%"},1E-3,92.5,38031,"JN962273.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Dtwd1:tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",84.2,228,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},94.44,39519,"JN949871.1",null,"Mouse DNA sequence from clone RP23-17N7 on chromosome 11, complete sequence","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":2e-09,"d":"2.00E-09"},91.38,201123,"AL713875.14",{"$nulls":11},"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Foxj2:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",76.8,76.8,{"v":0,"d":"0%"},{"v":1e-09,"d":"1.00E-09"},94,38840,"JN963559.1",null,"Mus musculus BAC clone RP24-208P4 from chromosome 8, complete sequence","Mus musculus",86.1,153,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},91.94,212819,"AC140672.5",null,"Mus musculus chromosome 13, clone RP23-216P14, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},92.86,238967,"AC126408.6"]
["Mus musculus 10 BAC RP23-182J19 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence","Mus musculus",67.6,191,{"v":0,"d":"0%"},{"v":7e-07,"d":"7.00E-07"},95.24,219859,"AC153911.5",null,"Mus musculus BAC RP23-128O3 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence","Mus musculus",56.5,56.5,{"v":0,"d":"0%"},1E-3,100,174134,"AC153800.1",null,"PREDICTED: Mus musculus slingshot protein phosphatase 2 (Ssh2), transcript variant X4, mRNA","Mus musculus",82.4,144,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},87.5,9233,"XM_030245966.2",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Rnf185:tm2a(EUCOMM)Wtsi tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":2e-09,"d":"2.00E-09"},91.38,36607,"JN962024.1",{"$nulls":11},"Mouse DNA sequence from clone RP23-190O8 on chromosome 4, complete sequence","Mus musculus",76.8,76.8,{"v":0,"d":"0%"},{"v":1e-09,"d":"1.00E-09"},89.06,189819,"AL732615.15",null,"Mus musculus chromosome 8, clone RP23-401L9, complete sequence","Mus musculus",86.1,153,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},91.94,209525,"AC104882.30",null,"Mouse DNA sequence from clone RP23-211O9 on chromosome 13, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},92.86,229171,"CT009762.8"]
["Mouse DNA sequence from clone DN-258P20 on chromosome 4, complete sequence","Mus musculus",65.8,246,{"v":0.01,"d":"1%"},{"v":2e-06,"d":"2.00E-06"},97.37,203649,"CU210866.8",null,"Mus musculus BAC clone RP23-283B12 from chromosome 14, complete sequence","Mus musculus",56.5,56.5,{"v":0,"d":"0%"},1E-3,96.97,189102,"AC154646.2",null,"PREDICTED: Mus musculus slingshot protein phosphatase 2 (Ssh2), transcript variant X6, mRNA","Mus musculus",82.4,144,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},87.5,27013,"XM_036156661.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rnf185:tm2e(EUCOMM)Wtsi tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",78.7,78.7,{"v":0,"d":"0%"},{"v":2e-09,"d":"2.00E-09"},91.38,36705,"JN950155.1",{"$nulls":11},"Mus musculus chromosome 8, clone RP23-338K3, complete sequence","Mus musculus",76.8,337,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94.12,213363,"AC164399.4",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Slc38a8:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",86.1,153,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},91.94,37962,"JN956747.1",null,"Mus musculus chromosome 17, clone RP23-166P7, complete sequence","Mus musculus",80.5,80.5,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},92.86,229687,"AC107765.9"]
["Mus musculus targeted non-conditional, lacZ-tagged mutant allele Naaa:tm1e(KOMP)Wtsi; transgenic","Mus musculus",65.8,189,{"v":0,"d":"0%"},{"v":2e-06,"d":"2.00E-06"},95.12,37865,"JN953652.1",null,"Mus musculus chromosome 14, clone RP24-218I13, complete sequence","Mus musculus",56.5,56.5,{"v":0,"d":"0%"},1E-3,96.97,138803,"AC119886.7",null,"PREDICTED: Mus musculus slingshot protein phosphatase 2 (Ssh2), transcript variant X3, mRNA","Mus musculus",82.4,144,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},87.5,27148,"XM_006533229.5",null,"Mouse DNA sequence from clone RP23-391P24 on chromosome 2, complete sequence","Mus musculus",76.8,76.8,{"v":0,"d":"0%"},{"v":6E-9,"d":"6.00E-09"},78.95,176778,"AL845336.9",{"$nulls":11},"Mus musculus BAC clone RP23-46L17 from chromosome 6, complete sequence","Mus musculus",76.8,76.8,{"v":0,"d":"0%"},{"v":1e-09,"d":"1.00E-09"},94,234330,"AC163108.5",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Slc38a8:tm1a(EUCOMM)Hmgu; transgenic","Mus musculus",86.1,153,{"v":0,"d":"0%"},{"v":5e-12,"d":"5.00E-12"},91.94,37966,"JN947047.1",null,"Mouse DNA sequence from clone RP23-17N7 on chromosome 11, complete sequence","Mus musculus",80.5,153,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},96,201123,"AL713875.14"]
["Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Naaa:tm1a(KOMP)Wtsi; transgenic","Mus musculus",65.8,189,{"v":0,"d":"0%"},{"v":2e-06,"d":"2.00E-06"},95.12,37921,"JN949702.1",null,"Mus musculus 10 BAC RP23-36F22 (Roswell Park Cancer Institute (C57BL/6J Female) Mouse BAC Library) complete sequence","Mus musculus",56.5,56.5,{"v":0,"d":"0%"},1E-3,100,214493,"AC152982.1",null,"PREDICTED: Mus musculus slingshot protein phosphatase 2 (Ssh2), transcript variant X7, mRNA","Mus musculus",82.4,144,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},87.5,9107,"XM_036156662.1",null,"TPA: Mus musculus SRP RNA for signal recognition particle RNA","Mus musculus",75,75,{"v":0,"d":"0%"},{"v":2E-8,"d":"2.00E-08"},85.14,290,"HG323688.1",{"$nulls":11},"Mus musculus chromosome 8, clone RP23-73E9, complete sequence","Mus musculus",76.8,337,{"v":0.01,"d":"1%"},{"v":1e-09,"d":"1.00E-09"},94.12,225655,"AC099690.8",null,"Mouse DNA sequence from clone RP23-283C20 on chromosome 2, complete sequence","Mus musculus",84.2,239,{"v":0,"d":"0%"},{"v":2e-11,"d":"2.00E-11"},92.98,103659,"AL845520.9",null,"Mus musculus targeted KO-first, conditional ready, lacZ-tagged mutant allele Rnf185:tm2a(EUCOMM)Wtsi tm1a(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,153,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},96,36607,"JN962024.1"]
["Mus musculus chromosome 18, clone RP24-122C12, complete sequence","Mus musculus",65.8,193,{"v":0.01,"d":"1%"},{"v":2e-06,"d":"2.00E-06"},91.49,172481,"AC102240.12",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Noc3l:tm1e(KOMP)Wtsi; transgenic","Mus musculus",56.5,56.5,{"v":0,"d":"0%"},1E-3,92.5,38012,"JN950393.1",null,"PREDICTED: Mus musculus slingshot protein phosphatase 2 (Ssh2), transcript variant X5, mRNA","Mus musculus",82.4,144,{"v":0,"d":"0%"},{"v":7e-11,"d":"7.00E-11"},87.5,8978,"XM_036156660.1",null,"Mus musculus STARR-positive B cell enhancer ABC_E600 (LOC132442538) on chromosome 12","Mus musculus",75,75,{"v":0,"d":"0%"},{"v":2E-8,"d":"2.00E-08"},85.14,502,"NG_238960.1",{"$nulls":11},"Mus musculus complement component 3a receptor 1 (C3ar1) gene, complete cds","Mus musculus",76.8,76.8,{"v":0,"d":"0%"},{"v":1e-09,"d":"1.00E-09"},94,518084,"EU007909.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Stx12:tm1e(EUCOMM)Hmgu; transgenic","Mus musculus",82.4,409,{"v":0.01,"d":"1%"},{"v":6E-11,"d":"6.00E-11"},85.54,38001,"JN958365.1",null,"Mus musculus targeted non-conditional, lacZ-tagged mutant allele Rnf185:tm2e(EUCOMM)Wtsi tm1e(EUCOMM)Wtsi; transgenic","Mus musculus",80.5,153,{"v":0,"d":"0%"},{"v":2e-10,"d":"2.00E-10"},96,36705,"JN950155.1"]

{"sheet":"Supplementary Table S11.","index":11,"n_rows":71,"n_cols":5,"rows_kept":71}
["Supplementary Table S11. - Average expression of genes in P0 mouse auditory and vestibular epithelia, comparing hair cells, epithelial non-hair cells, and non-epithelial cells (Elkon et al., 2015)"]
[null,"Cochlea",null,"Vestibular"]
["Genes","Cochlear_Epithelial_HC","Cochlear_Epithelial_Nonsensory","Vestibular_Epithelial_HC","Vestibular_Epithelial_Nonsensory"]
["CABP2",4.554589,4.491853,8.02098,4.392317]
["CHSY1",10.48884,11.71671,11.73164,9.429407]
["CIB2",9.85915,5.321928,8.561288,5.348728]
["CLPP",4.392317,4.820179,4.392317,5.434628]
["CLRN1",10.36359,4.942514,9.87537,4.672425]
["COL9A2",7.398744,10.09144,6.758223,11.27088]
["COL9A3",8.296913,11.44799,7.426265,12.67854]
["EPS8L2",7.638436,4.491853,7.044394,5.554589]
["GRXCR1",9.645658,4.554589,9.414685,4.392317]
["HARS2",7.48748,6.933691,6.731319,6.546895]
["HOMER2",11.27176,9.016809,9.81738,8.915133]
["HSD17B4",7.667111,9.117643,7.782998,9.302068]
["KCNE1",4.643856,7.131857,4.930737,9.391244]
["MARVELD2",8.835261,8.226412,8.059344,8.340962]
["MPZL2",8.764872,12.17804,9.658212,12.58918]
["MYO3A",12.15054,6.108524,9.265615,4.392317]
["MYO6",14.86888,10.64813,14.4232,10.33092]
["NR2F1",13.65648,13.7059,10.55099,9.96651]
["OTOA",5.965784,10.07948,7.776433,11.05138]
["OTOG",9.81458,10.48558,10.85954,13.41283]
["OTOGL",9.057315,11.23826,9.438792,9.673751]
["REST",10.78279,11.88595,10.65441,11.3903]
["SLC17A8",10.04849,6.948367,13.52903,6.23362]
["TPRN",5.971544,5.266787,5.721099,5.219169]
["TRIOBP",8.800091,7.076816,9.257977,7.473706]
["Tprn",5.971544,5.266787,5.721099,5.219169]
["Ush1c",7.912889,6.361944,9.328114,8.884933]
["A730017C20Rik",11.28584,8.918118,11.27612,9.569856]
["Eps8l1",4.392317,4.857981,4.409391,5.761551]
["Klc2",6.022368,5.247928,5.839204,5.022368]
["Nedd4l",8.606405,9.652397,9.032045,8.950556]
["Nptn",11.58496,11.74494,12.0601,10.2799]
["Spns2",4.392317,4.392317,4.392317,5.076816]
["Tmtc4",11.22234,9.724514,11.8008,8.634811]
["Tox",11.13987,10.86902,11.60096,10.77684]
["Zfp719",8.432542,7.495855,9.091435,7.571753]
["Acvr2a",11.04678,11.09968,11.02722,9.99223]
["Ankrd11",10.20182,9.392318,9.584963,10.2662]
["Ap3m2",8.799282,5.936638,8.158609,6.139551]
["Ap3s1",9.145932,10.16239,9.735979,8.483816]
["Baiap2l2",6.707359,4.392317,5.523562,4.392317]
["Ccdc92",6.154818,4.629356,5.839204,5.693487]
["Cyb5r2",4.942514,4.39217,5.864186,4.392317]
["Gga1",4.392317,5.238405,4.392317,5.459432]
["Mpdz",11.51742,10.10852,11.66322,10.29978]
["Nisch",9.98157,10.04508,10.32615,11.45777]
["Tram2",8.262094,9.514714,6.618385,9.703038]
["Ube2b",10.81898,11.06878,10.92611,10.71768]
["Ube2g1",10.61747,10.53916,9.88798,10.28106]
["Vti1a",7.473706,7.451211,7.131857,7.609179]
["Aak1",9.97621,7.583083,10.03995,7.820179]
["Acsl4",13.62005,10.90839,13.00834,9.767771]
["Ccdc88c",8.98014,6.867279,8.076816,6.60733]
["Dnase1",7.571753,6.139551,6.049849,6.784635]
["Emb",9.497353,8.161132,9.80292,6.957102]
["Ewsr1",9.88912,9.133142,10.05257,9.79969]
["Gpr152",5.761551,4.392317,5.348728,4.392317]
["Ikzf5",9.042343,9.270295,9.101319,8.78054]
["Nin",10.971,8.447038,10.46684,7.465567]
["Phf6",11.37816,10.42574,10.61195,9.715533]
["Ppm1a",9.8498,10.3122,9.603626,9.642954]
["Wdtc1",7.355351,6.430452,7.550747,7.144658]
["Atp2b1",13.20274,11.95065,12.18696,12.78984]
["Klhl18",5.442944,5.930737,4.554589,6.228819]
["Med28",7.932215,7.592457,8.266787,7.674192]
["Nfatc3",9.84823,9.517178,9.83329,10.40408]
["Sema3f",4.507795,5.409391,4.672425,6.807355]
["Zcchc14",8.099348,8.507794,8.200898,8.79279]

{"sheet":"Supplementary Table S12.","index":12,"n_rows":16,"n_cols":8,"rows_kept":16}
["Supplementary Table S12. - Average expression of genes in P2 mouse cochlea across apical, middle, and basal turns (Yoshimura et al., 2014)"]
[]
[null,null,"Fold Change"]
["Position","Gene","apex/basal","up in apex/basal","apex/middle","up in apex/middle","middle/basal","up in middle/basal"]
[1,"Cabp2",1.7791357,"apex",1.1396064,"middle",2.0275145,"middle"]
[2,"Clrn1",3.0172749,"apex",1.0656272,"apex",2.8314543,"middle"]
[3,"Grxcr1",{"v":3.925346,"d":"3.9253460"},"apex",{"v":1.482661,"d":"1.4826610"},"apex",2.6475008,"middle"]
[4,"Otog",2.4337175,"apex",1.5385773,"apex",1.5817974,"middle"]
[5,"Slc17a8",3.1493604,"apex",1.3340826,"apex",2.3606937,"middle"]
[6,"Elmod1",{"v":2.87728,"d":"2.8772800"},"apex",1.1764473,"apex",2.4457364,"middle"]
[7,"Ocm",3.7825994,"apex",1.4431521,"apex",{"v":2.621068,"d":"2.6210680"},"middle"]
[8,"Ush1c",2.0442185,"apex",1.3303728,"apex",1.5365758,"middle"]
[9,"Tox",3.1935737,"apex",1.5801938,"apex",2.0210013,"middle"]
[10,"Slc4a10",{"v":3.501798,"d":"3.5017980"},"basal",1.8278946,"middle",1.9157548,"basal"]
[11,"Gpr152",4.7057457,"apex",1.2752459,"apex",3.6900694,"middle"]
[12,"Nin",{"v":2.204199,"d":"2.2041990"},"apex",1.2406529,"apex",1.7766443,"middle"]

{"sheet":"Supplementary Table S13.","index":13,"n_rows":6,"n_cols":10,"rows_kept":6}
["Supplementary Table S13. - Average expression of genes in adult (6-week) mouse cochlea (Waldhaus et al., 2015)"]
[]
["Genes","Inner_HC","Outer_HC","Deiter_1_and_2","Deiter_3","Inner_Border","Inner_Phala","Inner_Pillar","Outer_Pillar","GER"]
["CLRN1",3.220994,3.23445,2.223478,2.404771,1.096703,2.419497,2.546715,2.276602,1.702886]
["GJB3",1.987367,1.685598,2.087259,2.212704,0.6006858,2.355456,2.350133,2.231647,1.716381]
["MYO6",3.590753,3.625383,3.029564,2.964382,2.235961,2.567687,2.860104,3.069965,2.539687]

{"sheet":"Supplementary Table S14.","index":14,"n_rows":352,"n_cols":9,"rows_kept":352}
["Supplementary Table S14. -  Auditory Brainstem Response (ABR) of genes according to IMPC"]
[]
[null,"Frequency (kHz) "]
["Gene","Click ",6,12,18,24,30,null,"Frequency_Categories"]
["ATP2B1",{"$nulls":7},"Low Frequency "]
["Male Het",20,75,47.5,37.5,40,50,null,"High Frequency "]
["Male WT",13.324,43.432,24,25.27,35.108,49.754,null,"Mild Hearing Loss "]
["Female Het",20,67.5,30,35,37.5,55,null,"Severe Hearing Loss"]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["KLHL18"]
["Male Hom",50,79.286,66.429,56.429,49.286,53.571]
["Male WT",25,32.045,16.25,19.318,29.205,38.75]
["Female Hom",60,85,80,55,65,50]
["Female WT",25.093,31.852,17.13,20.185,28.611,29.259]
["MED28"]
["Male Het",15,72.5,25,27.5,37.5,45]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Het",12.5,75,25,27.5,32.5,47.5]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["SEMA3F"]
["Male Hom",46,68,43,41,38,48]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.283]
["Female Hom",40,65,47.5,35,50,62.5]
["Female WT",37.273,46.472,31.299,37.013,37.485,50.974]
["ZCCHC14"]
["Male Hom",27.5,50,32.5,32.5,35,47.5]
["Male WT",25,32.045,16.25,19.318,29.205,38.75]
["Female Hom",30,55,30,30,35,60]
["Female WT",25.093,31.852,17.13,20.185,28.611,39.259]
["Male WT_Median",{"$f":"AVERAGE(B11,B15,B19,B23,B27)","v":32.18575},{"$f":"AVERAGE(C11,C15,C19,C23,C27)","v":54.711},38.260000000000005,34.164,41.153499999999994,51.89375]
["Female WT_Median",{"$f":"AVERAGE(B13,B17,B21,B25,B29)","v":36.10425},{"$f":"AVERAGE(C13,C17,C21,C25,C29)","v":57.071000000000005},41.0325,35.363749999999996,41.67975,46.753249999999994]
["AAK1"]
["Male Hom",20,70,40,42.5,50,87.5]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",22.5,60,45,47.5,45,60]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["ACSL4"]
["Male Hom"]
["Male WT",25,35,18.333,20,30,40]
["Female Hom",30,30,20,28.333,66.667,91.667]
["Female WT",26.25,32.5,17.5,23.125,30,41.25]
["CCDC88C"]
["Male Hom",20,57.5,37.5,47.5,82.5,100]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",17.5,57.5,35,60,75,100]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["DNASE1"]
["Male Hom",30,57.5,30,50,65,100]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",42.5,62.5,45,60,82.5,100]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["EMB"]
["Male Hom"]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",17.5,40,37.5,55,82.5,100]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["EWSR1"]
["Male Hom"]
["Male WT",19.297,33.516,20.078,25.137,33.242,47.031]
["Female Het",20,31.25,22.5,23.75,46.25,61.25]
["Female WT",20.04,33.261,20.059,25.257,33.715,48.3]
["GPR152"]
["Male Hom",26.429,31.429,17.143,20,35.714,70.714]
["Male WT",24.622,31.822,17.433,19.963,26.76,36.919]
["Female Hom",25,32.5,15,25,45,87.5]
["Female WT",25.882,31.587,17.733,21.373,28.363,39.521]
["IKZF5"]
["Male Hom",16.65,6.8,8.95,41.75,69.25,82.15]
["Male WT",13.354,4.484,5.772,9.51,24.542,36.905]
["Female Hom"]
["Female WT",10.689,3.712,3.007,8.658,24.807,41.804]
["NIN"]
["Male Hom",41.65,26.8,46.45,78,91.75,95.9]
["Male WT",13.354,4.484,5.772,9.51,24.542,36.905]
["Female Hom"]
["Female WT",10.689,3.712,3.007,8.658,24.807,41.804]
["PHF6"]
["Male Hom"]
["Male WT",null,36.137,14.898,16.052,26.207,41.475]
["Female Hom",null,40.833,19.167,25.833,63.333,75]
["Female WT",null,36.449,15.333,17.412,29.28,48.462]
["PPM1A"]
["Male Hom",42.5,60,35,32.5,62.5,77.5]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.238]
["Female Hom",42.5,52.5,32.5,40,50,77.5]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["WDTC1"]
["Male Hom",25,31.667,16.667,18.333,28.333,38.333]
["Male WT",25,32.045,16.25,19.318,29.205,38.75]
["Female Hom",40,38.75,30,61.25,95,95]
["Female WT",25.093,31.852,17.13,20.185,28.611,39.259]
["Male WT_Median",{"$f":"AVERAGE(B89,B85,B81,B76,B72,B68,B65,B62,B58,B54,B51, B79)","v":20.98657142857143},{"$f":"AVERAGE(C89,C85,C81,C76,C72,C68,C65,C62,C58,C54,C51, C79)","v":31.787555555555553},16.977666666666668,24.37433333333333,38.331111111111106,57.794333333333334]
["Female WT_Median",{"$f":"AVERAGE(B91,B87, B83,B80,B77,B74,B70,B67,B64,B60,B56,B53)","v":23.218666666666667},{"$f":"AVERAGE(C91,C87, C83,C80,C77,C74,C70,C67,C64,C60,C56,C53)","v":34.67914285714286},19.980428571428572,22.521428571428572,41.15985714285715,54.226714285714294]
["ACVR2A"]
["Male Het",15,27.5,17.5,20,25,42.5]
["Male WT",17.7,34,19.9,21.9,27.8,39.1]
["Female Het",22.5,27.5,20,27.5,32.5,37.5]
["Female WT",18.137,31.275,19.412,22.745,28.725,42.255]
["ANKRD11"]
["Male Hom",null,47.857,26.429,21.429,30.714,49.286]
["Male WT",null,36.137,14.898,16.052,26.207,41.475]
["Female Hom",null,69.375,39.375,38.125,60,81.875]
["Female WT",null,36.449,15.332,17.412,29.28,48.462]
["AP3M2"]
["Male Hom"]
["Male WT"]
["Female Hom"]
["Female WT"]
["AP3S1"]
["Male Hom"]
["Male WT"]
["Female Hom"]
["Female WT"]
["BAIAP2L2"]
["Male Hom",null,70.3,89.7,92.867,87.7,94.4]
["Male WT",null,36.137,14.898,16.052,26.207,41.475]
["Female Hom",null,75.767,93.233,92.167,87.2,94.4]
["Female WT",null,36.449,15.332,17.412,29.28,48.462]
["CCDC92"]
["Male Hom",25,67.5,52.5,45,60,80]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",17.5,65,32.5,32.5,50,70]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["CYB5R2"]
["Male Hom",42.5,47.5,47.5,47.5,60,80]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.238]
["Female Hom",46.25,48.75,48.75,52.5,50,70]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["GGA1"]
["Male Hom",40,75,65,65,75,90]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",15,65,42.5,42.5,45,62.5]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["MPDZ"]
["Male Hom",null,65,78.75,81.25,71.25,86.25]
["Male WT",null,48.156,45.474,34.357,44.907,60.415]
["Female Hom",null,82.5,83.75,87.5,76.25,87.5]
["Female WT",null,46.881,44.703,34.48,44.447,59.051]
["NISCH"]
["Male Hom",55,72.5,50,60,62.5,82.5]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.238]
["Female Hom",60,57.5,52.5,52.5,52.5,47.5]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["SLC4A10"]
["Male Hom",67.5,75,37.5,62.5,72.5,70]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.238]
["Female Hom",77.5,82.5,65,75,72.5,80]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["TRAM2"]
["Male Hom",60,71.667,51.667,48.333,63.333,68.333]
["Male WT",25,32.045,16.25,19.318,29.205,38.75]
["Female Hom",65,84,64,60,62,75]
["Female WT",25.093,31.852,17.13,20.185,28.611,39.259]
["UBE2B"]
["Male Hom",47.5,60,40,50,47.5,57.5]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.283]
["Female Hom",55,70,57.5,52.5,60,57.5]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["UBE2G1"]
["Male Hom",51.65,44.3,38.95,36.75,51.75,57.15]
["Male WT",13.354,4.484,5.772,9.51,24.542,36.905]
["Female Hom"]
["Female WT",10.689,3.712,3.007,8.658,24.807,41.804]
["VTI1A"]
["Male Hom",20,70,40,42.5,50,87.5]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",22.5,60,45,47.5,45,60]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["REST"]
["Male Het",35,42.5,25,25,37.5,42.5]
["Male WT",35.401,47.472,30.267,34.388,42.659,58.477]
["Female Het",31.25,35,21.25,23.75,35,40]
["Female WT",36.236,46.729,30.241,34.737,44.12,61.891]
["OTOG"]
["Male Hom",null,83.75,95,77.5,85,86.25]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Hom",null,85,88.75,78.75,81.25,93.75]
["Female WT",null,48.239,46.969,36.285,43.967,61.36]
["NR2F1"]
["Male Het",null,65,55,42.5,52.5,66.25]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Het",null,58.75,50,37.5,45,58.75]
["Female WT",null,48.239,46.969,36.285,43.967,61.36]
["MYO3A"]
["Male Hom",null,57.5,66.25,45,43.75,58.75]
["Male WT",null,48.156,45.747,34.357,44.907,60.415]
["Female Hom",null,60,70,58.75,50,71.25]
["Female WT",null,46.881,44.703,34.48,44.447,59.051]
["MPZL2"]
["Male Hom"]
["Male WT",37.083,47.348,41.657,37.866,41.636,49.114]
["Female Hom",66.25,62.5,51.25,67.5,65,68.333]
["Female WT",37.415,47.869,42.186,36.215,39.451,51.667]
["CHSY1"]
["Male Hom",37.5,82.5,42.5,32.5,32.5,85]
["Male WT",13.35,38.2,21.4,23.9,32.75,46.786]
["Female Hom",47.5,77.5,50,50,47.5,80]
["Female WT",13.824,37.843,21.324,25.294,35.098,54.554]
["CLPP"]
["Male Hom",35,38.333,23.333,23.333,35,80]
["Male WT",24.622,31.822,17.433,19.963,26.76,36.919]
["Female Hom",30,40,20,23.75,36.25,57.5]
["Female WT",25.882,31.587,17.733,21.373,28.363,39.521]
["COL9A3"]
["Male Hom",31.667,40,23.333,35,46.667,56.667]
["Male WT",19.297,33.516,20.078,25.137,33.242,47.031]
["Female Hom",36.667,41.667,28.333,36.667,46.667,58.333]
["Female WT",20.04,33.261,20.059,25.257,33.615,48.3]
["HOMER2"]
["Male Hom",null,76.25,77.5,95,81.25,80]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Hom",null,82.5,78.75,90,80,85]
["Female WT",null,48.239,49.969,36.285,43.967,61.36]
["HSD17B4"]
["Male Hom",27.5,47.5,25,32.5,37.5,52.5]
["Male WT",19.297,33.516,20.078,25.137,33.242,47.031]
["Female Hom",25,45,30,35,45,55]
["Female WT",20.04,33.262,20.059,25.257,33.715,48.3]
["HARS2"]
["Male Het",null,35,35,30,38.75,53.75]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Het",null,33.75,31.25,38.75,48.75,63.75]
["Female WT",null,48.239,46.969,36.285,43.967,61.36]
["GJB3"]
["Male Het",25,56.25,37.5,38.75,45,63.75]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Het",15,50,30,32.5,50,65]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["Male WT_Median",{"$f":"AVERAGE(B132,B136,B140,B144,B148,B152,B156,B160,B164,B168,B172,B176,B179,B183,B187,B191,B195,B198,B202,B206,B210,B214,B218,B222,B226)","v":31.738666666666674},{"$f":"AVERAGE(C132,C136,C140,C144,C148,C152,C156,C160,C164,C168,C172,C176,C179,C183, C187,C191,C195,C198,C202,C206,C210,C214,C218,C222,C226)","v":50.994571428571426},{"$f":"AVERAGE(D132,D136,D140,D144,D148,D152,D156,D160,D164,D168,D172,D176,D179,D183,D187,D191,D195,D198,D202,D206,D210,D214,D218,D222,D226)","v":38.46947619047618},{"$f":"AVERAGE(E132,E136,E140,E144,E148,E152,E156,E160,E164,E168,E172,E176,E179,E183,E187,E191,E195,E198,E202,E206,E210,E214,E218,E222,E226)","v":38.86519047619048},{"$f":"AVERAGE(F132,F136,F140,F144,F148,F152,F156,F160,F164,F168,F172,F176,F179,F183,F187,F191,F195,F198,F202,F206,F210,F214,F218,F222,F226)","v":44.179666666666655},{"$f":"AVERAGE(G132,G136,G140,G144,G148,G152,G156,G160,G164,G168,G172,G176,G179,G183,G187,G191,G195,G198,G202,G206,G210,G214,G218,G222,G226)","v":59.86542857142856}]
["Female WT_median",{"$f":"AVERAGE(B134,B138,B142,B146,B150,B154,B158,B162,B166,B170,B174,B177,B181,B185,B189,B193,B197,B200,B204,B208,B212,B216,B220, B224,B228)","v":34.55733333333334},{"$f":"AVERAGE(C134,C138,C142,C146,C150,C154,C158,C162,C166,C170,C174,C177,C181,C185,C189,C193,C197,C200,C204,C208,C212,C216,C220, C224,C228)","v":52.124944444444445},41.81244444444443,40.23488888888889,45.58588888888889,59.85205555555555]
["CIB2"]
["Male Hom",100,100,100,100,100,100]
["Male WT",36.096,47.566,29.048,36.123,38.04,48.283]
["Female Hom",100,100,100,100,100,100]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["CLRN1"]
["Male Hom",100,100,100,100,100,100]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",100,100,100,100,100,100]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["COL9A2"]
["Male Hom",80,92.5,67.5,72.5,92.5,90]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.238]
["Female Hom",80,72.5,62.5,67.5,70,90]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["ELMOD1"]
["Male Hom",100,100,100,100,100,100]
["Male WT",35.927,41.732,37.098,36.244,36.78,48.878]
["Female Hom",100,100,100,100,100,100]
["Female WT",34.667,39.333,35.0501,35.718,35.128,48.385]
["MARVELD2"]
["Male Hom",100,100,100,100,100,100]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.238]
["Female Hom",100,92.5,100,90,90,90]
["Female WT",37.273,46.472,31.299,37.013,38.485,50.974]
["OTOA"]
["Male Hom",55,86.25,72.5,73.75,78.75,88.75]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",55,88.75,75,77.5,81.25,93.75]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["TPRN"]
["Male Hom",null,100,100,100,100,100]
["Male WT",null,48.156,45.474,34.357,44.907,60.415]
["Female Hom",null,100,100,100,100,100]
["Female WT",null,46.881,44.703,34.48,44.447,59.051]
["USH1C"]
["Male Hom",95,95,95,93.75,95,95]
["Male WT",25,32.045,16.25,19.318,29.205,38.75]
["Female Hom",95,95,95,95,95,95]
["Female WT",25.093,31.852,17.13,20.185,28.611,39.259]
["A730017C20RIK"]
["Male Hom",95,95,95,95,95,95]
["Male WT",24.622,31.822,17.433,19.963,26.76,36.919]
["Female Hom",95,95,95,95,95,95]
["Female WT",25.882,31.587,17.733,21.373,28.363,39.521]
["EPS8L1"]
["Male Hom",83.571,89.286,80.714,82.857,84.286,90]
["Male WT",24.622,31.822,17.433,19.963,26.76,36.919]
["Female Hom",58.333,75,65.833,50.833,55.833,71.667]
["Female WT",25.882,31.587,17.733,21.373,28.363,39.521]
["KLC2"]
["Male Hom",83.571,89.286,80.714,82.857,84.286,90]
["Male WT",24.622,31.822,17.433,19.963,26.76,36.919]
["Female Hom",58.333,75,65.833,50.833,55.833,71.667]
["Female WT",25.882,31.587,17.733,21.373,28.363,39.521]
["NEDD4L"]
["Male Hom",100,100,100,100,100,100]
["Male WT",36.096,47.566,29.408,36.123,38.04,48.238]
["Female Hom",100,100,100,100,100,100]
["Female WT",37.73,46.472,31.299,37.013,38.485,50.974]
["NPTN"]
["Male Hom",92.5,85,90,85,80,92.5]
["Male WT",35.927,41.732,37.098,36.244,36.78,48.878]
["Female Hom",90,100,87.5,100,90,100]
["Female WT",34.677,39.333,35.051,35.718,35.128,48.385]
["SPNS2"]
["Male Hom",95,95,95,95,95,95]
["Male WT",25,29.773,15.455,19.318,27.182,43.636]
["Female Hom",95,95,95,95,95,95]
["Female WT",26.19,31.667,16.905,20.952,31.905,44.286]
["TOX"]
["Male Hom",82.5,100,95,95,100,100]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",100,100,100,100,100,100]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["TMTC4"]
["Male Hom",60,100,100,100,90,100]
["Male WT",13.324,43.432,24,25.27,35.108,49.754]
["Female Hom",85,100,100,100,100,100]
["Female WT",13.743,42.513,22.861,25.909,36.123,52.754]
["ZFP719"]
["Male Hom",60,57.5,76.25,95,95,95]
["Male WT",24.622,31.822,17.433,19.963,26.76,36.919]
["Female Hom",75.833,72.5,82.5,92.5,95,95]
["Female WT",25.882,31.587,17.733,21.373,28.363,39.521]
["TRIOBP"]
["Male Hom",null,100,100,100,100,100]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Hom",null,100,100,100,100,100]
["Female WT",null,48.239,46.969,36.285,43.967,61.36]
["SLC17A8"]
["Male Hom",87.5,100,100,100,100,100]
["Male WT",13.35,38.2,21.4,23.9,32.75,46.786]
["Female Hom",67.5,100,100,100,100,100]
["Female WT",13.824,37.843,21.324,25.294,35.098,54.554]
["OTOGL"]
["Male Hom",null,93.333,100,100,93.333,100]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Hom",null,100,100,100,100,100]
["Female WT",null,48.239,46.969,36.285,43.967,61.36]
["MYO6"]
["Male Hom",85,85,85,85,85,85]
["Male WT",19.297,33.516,20.078,25.137,33.242,47.031]
["Female Hom",85,85,85,85,85,85]
["Female WT",20.04,33.261,20.059,25.257,33.715,48.3]
["CABP2"]
["Male Hom",null,94,100,93,83,94]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Hom",null,90,100,100,92.5,88.75]
["Female WT",null,48.239,46.969,36.285,42.967,61.36]
["GRXCR1"]
["Male Hom",null,100,100,93.75,95,95]
["Male WT",null,49.239,46.78,35.908,42.452,59.985]
["Female Hom",null,100,100,100,100,100]
["Female WT",null,48.239,46.969,36.285,43.967,61.36]
["KCNE1"]
["Male Hom",null,91.667,91.667,91.667,91.667,91.667]
["Male WT",null,36.137,14.898,16.052,26.207,41.475]
["Female Hom",null,95,95,95,95,95]
["Female WT",null,36.449,15.332,17.412,29.28,48.462]
["Male WT_Median",{"$f":"AVERAGE(B348,B344,B340,B336,B332,B328,B324,B320,B316,B312,B308,B304,B300,B296,B292,B288,B284,B280,B276,B272,B268,B264,B260,B256)","v":53.736},{"$f":"AVERAGE(C348,C344,C340,C336,C332,C328,C324,C320,C316,C312,C308,C304,C300,C296,C292,C288,C284,C280,C276,C272,C268,C264,C260,C256)","v":63.58757894736842},{"$f":"AVERAGE(D348,D344,D340,D336,D332,D328,D324,D320,D316,D312,D308,D304,D300,D296,D292,D288,D284,D280,D276,D272,D268,D264,D260,D256)","v":57.624},57.06884210526316,61.32473684210525,70.35000000000001]
["Female WT_median",{"$f":"AVERAGE(B258,B262,B266,B270,B274,B278,B286,B290,B294,B302,B306,B310,B314,B318,B322,B330,B338, B350,B346,B342,B334,B326,B298,B282)","v":56.83969230769231},{"$f":"AVERAGE(C258,C262,C266,C270,C274,C278,C286,C290,C294,C302,C306,C310,C314,C318,C322,C330,C338, C350,C346,C342,C334,C326,C298,C282)","v":65.83242105263157},{"$f":"AVERAGE(D258,D262,D266,D270,D274,D278,D286,D290,D294,D302,D306,D310,D314,D318,D322,D330,D338, D350,D346,D342,D334,D326,D298,D282)","v":58.40805263157895},58.80410526315789,62.879263157894734,71.74147368421052]

{"sheet":"Supplementary Table S15.","index":15,"n_rows":486,"n_cols":11,"rows_kept":486}
["Supplementary Table S15.- Active biochemical pathways according to Gene Ontology - Biological Processes in Homosapiens."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["sensory perception of sound","GO:0007605",18,67,165,18228,{"v":4.12396962338416e-22,"d":"4.12E-22"},{"v":1.99187732809455e-19,"d":"1.99E-19"},29.6792401628223,0,"TRIOBP, OTOGL, KCNE1, MYO6, TPRN, CLRN1, CABP2, SPNS2, GRXCR1, USH1C, OTOG, SLC17A8, TMTC4, MARVELD2, MYO3A, HOMER2, OTOA, EPS8L2"]
["auditory receptor cell stereocilium organization","GO:0060088",4,67,21,18228,{"v":9.51761241926277e-07,"d":"9.52E-07"},0.000229850339925196,51.8208955223881,0,"TRIOBP, TPRN, CLRN1, REST"]
["inner ear receptor cell stereocilium organization","GO:0060122",4,67,27,18228,{"v":2.74495036179606E-6,"d":"2.74E-06"},0.000441937008249165,40.3051409618574,0,"OTOGL, GRXCR1, USH1C, OTOG"]
["L-arabinose metabolic process","GO:0046373",2,67,2,18228,{"v":1.33095853249704E-5,"d":"1.33E-05"},0.00128570594239214,272.059701492537,0,"OTOGL, OTOG"]
["vibrational conductance of sound to the inner ear","GO:0055127",2,67,2,18228,{"v":1.33095853249704E-5,"d":"1.33E-05"},0.00128570594239214,272.059701492537,0,"OTOGL, OTOG"]
["inner ear auditory receptor cell differentiation","GO:0042491",3,67,20,18228,{"v":5.17417943499288e-05,"d":"5.17E-05"},0.00416521444516927,40.8089552238806,0,"MYO6, GRXCR1, USH1C"]
["protein localization","GO:0008104",6,67,190,18228,{"v":6.97623096082007e-05,"d":"6.98E-05"},0.00481359936296585,8.59135899450118,0,"OTOGL, MYO6, OTOG, ELMOD1, GGA1, NIN"]
["synaptic vesicle coating","GO:0016183",2,67,5,18228,0.000132149022751269,0.00797849724860787,108.823880597015,0,"AP3S1, AP3M2"]
["equilibrioception","GO:0050957",2,67,7,18228,2.76196095823867E-4,0.0133402714282928,77.7313432835821,0,"CLRN1, USH1C"]
["clathrin-coated vesicle cargo loading, AP-3-mediated","GO:0035654",2,67,7,18228,2.76196095823867E-4,0.0133402714282928,77.7313432835821,0,"AP3S1, AP3M2"]
["photoreceptor cell maintenance","GO:0045494",3,67,45,18228,0.000603111217758372,0.0242752265147745,18.1373134328358,0,"CLRN1, USH1C, CIB2"]
["Golgi to vacuole transport","GO:0006896",2,67,10,18228,0.000587643831185771,0.0242752265147745,54.4119402985075,0,"AP3S1, VTI1A"]
["sensory perception of light stimulus","GO:0050953",2,67,13,18228,1.01135145239778E-3,0.0375755962698561,41.8553386911596,0,"CLRN1, USH1C"]
["synaptic vesicle recycling","GO:0036465",2,67,14,18228,0.00117711268052094,0.0406103874779724,38.865671641791,0,"AP3S1, AP3M2"]
["positive regulation of ruffle assembly","GO:1900029",2,67,15,18228,1.35498771920167E-3,0.0436306045582937,36.2746268656716,0,"EPS8L1, EPS8L2"]
["ventricular cardiac muscle cell action potential","GO:0086005",2,67,16,18228,1.54488795933496E-3,0.0466363052724242,34.0074626865672,0,"KCNE1, NEDD4L"]
["anterograde synaptic vesicle transport","GO:0048490",2,67,17,18228,1.74672526266311E-3,0.0496275471686047,32.0070237050044,0,"AP3S1, AP3M2"]
["vestibular receptor cell development","GO:0060118",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"GRXCR1"]
["NK T cell lineage commitment","GO:0002364",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"TOX"]
["very long-chain fatty-acyl-CoA metabolic process","GO:0036111",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"HSD17B4"]
["negative regulation of dense core granule biogenesis","GO:2000706",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"REST"]
["intracellular protein transport","GO:0006886",5,67,275,18228,0.00339673523085392,0.0589062910226368,4.94654002713704,0,"MYO6, AP3S1, GGA1, AP3M2, VTI1A"]
["synaptonemal complex organization","GO:0070193",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"UBE2B"]
["lymph node development","GO:0048535",2,67,21,18228,2.6716987005762E-3,0.0589062910226368,25.910447761194,0,"SPNS2, TOX"]
["intracellular chemical homeostasis","GO:0055082",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"WDTC1"]
["negative regulation of prostaglandin secretion","GO:0032307",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"ACSL4"]
["regulation of receptor localization to synapse","GO:1902683",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"NPTN"]
["regulation of eye pigmentation","GO:0048073",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"SPNS2"]
["regulation of Rho protein signal transduction","GO:0035023",2,67,25,18228,0.00378073503457917,0.0589062910226368,21.764776119403,0,"EPS8L1, EPS8L2"]
["regulation of acetylcholine uptake","GO:0051631",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"SLC17A8"]
["negative regulation of amniotic stem cell differentiation","GO:2000798",1,67,1,18228,0.00367566381391266,0.0589062910226368,272.059701492537,0,"REST"]
["monoatomic anion transport","GO:0006820",2,67,26,18228,4.0861163028439E-3,0.0616748179460502,20.9276693455798,0,"SLC17A8, SLC4A10"]
["cochlea development","GO:0090102",2,67,31,18228,0.00577758382578429,0.0656344947134754,17.5522388059702,0,"GRXCR1, SLC17A8"]
["negative regulation of miRNA transcription","GO:1902894",2,67,29,18228,0.00506841476211205,0.0656344947134754,18.7627380339681,0,"REST, NFATC3"]
["medium-chain fatty-acyl-CoA metabolic process","GO:0036112",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"HSD17B4"]
["protein modification by small protein conjugation","GO:0032446",2,67,31,18228,0.00577758382578429,0.0656344947134754,17.5522388059702,0,"UBE2B, UBE2G1"]
["CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment","GO:0002362",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"TOX"]
["vestibular nucleus development","GO:0021750",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"KCNE1"]
["CD4-positive, alpha-beta T cell lineage commitment","GO:0043373",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"TOX"]
["CD8-positive, alpha-beta T cell lineage commitment","GO:0043375",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"TOX"]
["regulation of humoral immune response","GO:0002920",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"SPNS2"]
["negative regulation of mesenchymal stem cell differentiation","GO:2000740",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"REST"]
["DN4 thymocyte differentiation","GO:1904157",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"NFATC3"]
["respiratory basal cell differentiation","GO:1902691",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"CCDC88C"]
["penile erection","GO:0043084",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"ACVR2A"]
["protein K48-linked ubiquitination","GO:0070936",3,67,95,18228,0.00516242693558797,0.0656344947134754,8.59135899450118,0,"NEDD4L, UBE2B, UBE2G1"]
["positive regulation of glutamate uptake involved in transmission of nerve impulse","GO:0051951",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"SLC17A8"]
["regulation of positive thymic T cell selection","GO:1902232",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"TOX"]
["histidyl-tRNA aminoacylation","GO:0006427",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"HARS2"]
["anterograde axonal transport","GO:0008089",2,67,31,18228,0.00577758382578429,0.0656344947134754,17.5522388059702,0,"AP3S1, AP3M2"]
["protein localization to microvillus","GO:1904106",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"USH1C"]
["multicellular organism growth","GO:0035264",3,67,102,18228,0.00628824643890163,0.0656344947134754,8.0017559262511,0,"WDTC1, OTOA, SLC4A10"]
["regulation of neutrophil mediated cytotoxicity","GO:0070948",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"DNASE1"]
["centrosome-templated microtubule nucleation","GO:0090222",1,67,2,18228,0.00733801804250035,0.0656344947134754,136.029850746269,0,"NIN"]
["membrane organization","GO:0061024",2,67,36,18228,0.00773582395582208,0.067934599466583,15.1144278606965,0,"AAK1, BAIAP2L2"]
["bicarbonate transport","GO:0015701",2,67,37,18228,0.00815859959455065,0.0691333965643502,14.7059298104074,0,"CYB5R2, SLC4A10"]
["visual perception","GO:0007601",4,67,215,18228,0.00808195659524589,0.0691333965643502,5.06157584172162,0,"CLRN1, CABP2, MYO3A, SLC4A10"]
["actin filament bundle assembly","GO:0051017",2,67,38,18228,0.00859156637821805,0.0715470096668848,14.318931657502,0,"USH1C, BAIAP2L2"]
["parallel actin filament bundle assembly","GO:0030046",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"USH1C"]
["positive regulation of endoplasmic reticulum calcium ion concentration","GO:0032470",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"TMTC4"]
["positive regulation of bone mineralization","GO:0030501",2,67,42,18228,0.0104237849923794,0.0774705831485878,12.955223880597,0,"ACVR2A, ATP2B1"]
["ventral trunk neural crest cell migration","GO:0036486",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"SEMA3F"]
["positive regulation of caveolin-mediated endocytosis","GO:2001288",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"NEDD4L"]
["outer hair cell apoptotic process","GO:1905584",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"TMTC4"]
["positive regulation of mitotic cell cycle phase transition","GO:1901992",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"KLHL18"]
["plasma membrane lactate transport","GO:0035879",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"EMB"]
["negative regulation of cytokine production","GO:0001818",2,67,41,18228,0.00995083256039275,0.0774705831485878,13.2712049508555,0,"ATP2B1, NPTN"]
["actin modification","GO:0030047",1,67,3,18228,0.0109871101521872,0.0774705831485878,90.6865671641791,0,"TRIOBP"]
["protein transport","GO:0015031",7,67,667,18228,0.011067226164084,0.0774705831485878,2.85519926603862,0,"MYO6, AP3S1, ELMOD1, TRAM2, GGA1, AP3M2, VTI1A"]
["regulation of actin filament length","GO:0030832",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"MYO3A"]
["trunk neural crest cell migration","GO:0036484",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"SEMA3F"]
["modification of synaptic structure","GO:0099563",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"REST"]
["synaptic vesicle to endosome fusion","GO:0016189",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"VTI1A"]
["positive regulation of reciprocal meiotic recombination","GO:0010845",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"UBE2B"]
["sympathetic neuron projection guidance","GO:0097491",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"SEMA3F"]
["negative regulation of cortisol biosynthetic process","GO:2000065",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"REST"]
["N-terminal protein myristoylation","GO:0006499",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"PPM1A"]
["negative regulation of post-translational protein modification","GO:1901874",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"UBE2B"]
["regulation of acute inflammatory response","GO:0002673",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"DNASE1"]
["presynaptic endocytosis","GO:0140238",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"AAK1"]
["stereocilium maintenance","GO:0120045",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"TPRN"]
["neuromuscular process controlling balance","GO:0050885",2,67,50,18228,0.0145539898529717,0.0830929757038777,10.8823880597015,0,"CLRN1, REST"]
["negative regulation of aldosterone biosynthetic process","GO:0032348",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"REST"]
["regulation of vascular associated smooth muscle contraction","GO:0003056",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"ATP2B1"]
["apical constriction","GO:0003383",1,67,4,18228,0.0146229874427114,0.0830929757038777,68.0149253731343,0,"CCDC88C"]
["intracellular transport","GO:0046907",2,67,53,18228,0.0162567458099872,0.0913024212351609,10.2664038299071,0,"AP3S1, AP3M2"]
["regulation of secretion","GO:0051046",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"MYO6"]
["auditory receptor cell morphogenesis","GO:0002093",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"USH1C"]
["secretory granule organization","GO:0033363",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"KCNE1"]
["Sertoli cell proliferation","GO:0060011",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"ACVR2A"]
["calcium ion export across plasma membrane","GO:1990034",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"ATP2B1"]
["lymphocyte migration","GO:0072676",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"SPNS2"]
["somatic stem cell population maintenance","GO:0035019",2,67,54,18228,0.0168424030322365,0.0927649649898925,10.0762852404643,0,"REST, MED28"]
["positive regulation of artery morphogenesis","GO:1905653",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"NFATC3"]
["protein localization to ciliary membrane","GO:1903441",1,67,5,18228,0.0182456970477014,0.0927649649898925,54.4119402985075,0,"GGA1"]
["odontogenesis of dentin-containing tooth","GO:0042475",2,67,59,18228,0.0199030070882485,0.0934168416524418,9.22236276245889,0,"ACVR2A, ANKRD11"]
["negative regulation of protein targeting to membrane","GO:0090315",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"KCNE1"]
["Peyer's patch development","GO:0048541",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"TOX"]
["neurotransmitter loading into synaptic vesicle","GO:0098700",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"SLC17A8"]
["corpus callosum morphogenesis","GO:0021540",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"NIN"]
["corticospinal tract morphogenesis","GO:0021957",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"NIN"]
["inner ear receptor cell development","GO:0060119",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"GRXCR1"]
["regulation of potassium ion transmembrane transporter activity","GO:1901016",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"NEDD4L"]
["L-glutamate import","GO:0051938",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"SLC17A8"]
["protein K63-linked ubiquitination","GO:0070534",2,67,61,18228,0.0211876808393397,0.0934168416524418,8.91999021287008,0,"UBE2B, UBE2G1"]
["Rho protein signal transduction","GO:0007266",2,67,62,18228,0.0218426888728307,0.0934168416524418,8.77611940298507,0,"EPS8L1, EPS8L2"]
["sympathetic neuron projection extension","GO:0097490",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"SEMA3F"]
["trigeminal nerve structural organization","GO:0021637",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"SEMA3F"]
["negative regulation of sodium ion transmembrane transport","GO:1902306",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"NEDD4L"]
["sperm ejaculation","GO:0042713",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"ACVR2A"]
["regulation of cellular pH","GO:0030641",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"SLC4A10"]
["regulation of synapse structure or activity","GO:0050803",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"SLC17A8"]
["neural crest cell migration involved in autonomic nervous system development","GO:1901166",1,67,6,18228,0.0218552859352503,0.0934168416524418,45.3432835820896,0,"SEMA3F"]
["inner ear morphogenesis","GO:0042472",2,67,66,18228,0.0245455969700686,0.0967970066047225,8.24423337856174,0,"MYO6, USH1C"]
["negative regulation of potassium ion transmembrane transporter activity","GO:1901017",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"NEDD4L"]
["voluntary musculoskeletal movement","GO:0050882",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"VTI1A"]
["long-chain fatty-acyl-CoA metabolic process","GO:0035336",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"ACSL4"]
["positive regulation of activin receptor signaling pathway","GO:0032927",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"ACVR2A"]
["regulation of delayed rectifier potassium channel activity","GO:1902259",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"KCNE1"]
["regulation of microvillus length","GO:0032532",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"USH1C"]
["tight junction assembly","GO:0120192",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"MPDZ"]
["homophilic cell adhesion via plasma membrane adhesion molecules","GO:0007156",3,67,167,18228,0.0235967128896319,0.0967970066047225,4.88730002681205,0,"MPZL2, EMB, NPTN"]
["branchiomotor neuron axon guidance","GO:0021785",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"SEMA3F"]
["cytokine production","GO:0001816",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"NFATC3"]
["vesicle-mediated transport","GO:0016192",4,67,303,18228,0.0253198916678088,0.0967970066047225,3.59154721442294,0,"AP3S1, GGA1, AP3M2, VTI1A"]
["leukocyte differentiation","GO:0002521",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"TOX"]
["embryonic process involved in female pregnancy","GO:0060136",1,67,7,18228,0.0254518009084881,0.0967970066047225,38.865671641791,0,"ACSL4"]
["monoatomic ion transmembrane transport","GO:0034220",4,67,305,18228,0.0258584733241749,0.0975753329341913,3.56799608514803,0,"ATP2B1, NEDD4L, SLC17A8, SLC4A10"]
["sodium-dependent phosphate transport","GO:0044341",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"SLC17A8"]
["regulation of defense response to virus","GO:0050688",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"CCDC92"]
["positive regulation of natural killer cell differentiation","GO:0032825",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"TOX"]
["chiasma assembly","GO:0051026",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"UBE2B"]
["brush border assembly","GO:1904970",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"USH1C"]
["SRP-dependent cotranslational protein targeting to membrane, translocation","GO:0006616",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"TRAM2"]
["regulation of T cell migration","GO:2000404",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"SPNS2"]
["cardiac muscle cell contraction","GO:0086003",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"KCNE1"]
["neutrophil activation involved in immune response","GO:0002283",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"DNASE1"]
["negative regulation of calcium ion-dependent exocytosis","GO:0045955",1,67,8,18228,0.0290352886061518,0.101623510121531,34.0074626865672,0,"REST"]
["regulation of nitric oxide biosynthetic process","GO:0045428",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"ACVR2A"]
["pyramidal neuron development","GO:0021860",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"SLC4A10"]
["lymphocyte differentiation","GO:0030098",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"TOX"]
["sympathetic ganglion development","GO:0061549",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"SEMA3F"]
["vesicle fusion with Golgi apparatus","GO:0048280",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"VTI1A"]
["negative regulation of vascular associated smooth muscle cell differentiation","GO:1905064",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"NFATC3"]
["positive regulation of long-term neuronal synaptic plasticity","GO:0048170",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"NPTN"]
["negative regulation of sodium ion transmembrane transporter activity","GO:2000650",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"NEDD4L"]
["membrane repolarization during action potential","GO:0086011",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"KCNE1"]
["meiotic telomere clustering","GO:0045141",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"UBE2B"]
["facial nerve structural organization","GO:0021612",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"SEMA3F"]
["inorganic ion transmembrane transport","GO:0098660",1,67,9,18228,0.0326057955031545,0.104990661520157,30.228855721393,0,"SLC4A10"]
["negative regulation of cAMP-mediated signaling","GO:0043951",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"UBE2B"]
["mucociliary clearance","GO:0120197",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"CCDC88C"]
["regulation of membrane depolarization","GO:0003254",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"NEDD4L"]
["membrane repolarization during cardiac muscle cell action potential","GO:0086013",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"KCNE1"]
["regulation of cellular response to insulin stimulus","GO:1900076",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"ATP2B1"]
["positive regulation of fibroblast growth factor receptor signaling pathway","GO:0045743",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"NPTN"]
["negative regulation of reproductive process","GO:2000242",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"UBE2B"]
["auditory receptor cell development","GO:0060117",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"CLRN1"]
["excitatory synapse assembly","GO:1904861",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"NPTN"]
["negative regulation of smooth muscle cell differentiation","GO:0051151",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"MED28"]
["negative regulation of axon extension involved in axon guidance","GO:0048843",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"SEMA3F"]
["negative regulation of cytosolic calcium ion concentration","GO:0051481",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"ATP2B1"]
["protein insertion into ER membrane","GO:0045048",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"TRAM2"]
["mitochondrial protein catabolic process","GO:0035694",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"CLPP"]
["chloride transport","GO:0006821",2,67,80,18228,0.0349969027519549,0.105222329524614,6.80149253731343,0,"SLC17A8, SLC4A10"]
["Sertoli cell development","GO:0060009",1,67,10,18228,0.036163367911151,0.105222329524614,27.2059701492537,0,"HSD17B4"]
["positive regulation of protein catabolic process","GO:0045732",2,67,82,18228,0.0366089084086331,0.105880854858502,6.63560247542774,0,"NEDD4L, GGA1"]
["microtubule anchoring at centrosome","GO:0034454",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"NIN"]
["transforming growth factor beta receptor superfamily signaling pathway","GO:0141091",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"ACVR2A"]
["retinal cone cell development","GO:0046549",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"USH1C"]
["negative regulation of delayed rectifier potassium channel activity","GO:1902260",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"KCNE1"]
["negative regulation of developmental process","GO:0051093",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"UBE2B"]
["cardiac muscle cell myoblast differentiation","GO:0060379",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"REST"]
["axon extension involved in axon guidance","GO:0048846",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"SEMA3F"]
["epithelial cell maturation","GO:0002070",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"KCNE1"]
["retrograde transport, endosome to Golgi","GO:0042147",2,67,84,18228,0.0382491500220538,0.108355870654841,6.47761194029851,0,"GGA1, VTI1A"]
["regulation of potassium ion transport","GO:0043266",1,67,11,18228,0.0397080519791032,0.108355870654841,24.7327001356852,0,"KCNE1"]
["regulation of clathrin-dependent endocytosis","GO:2000369",1,67,12,18228,0.0432398936938422,0.113504720946336,22.6716417910448,0,"AAK1"]
["negative regulation of protein localization to cell surface","GO:2000009",1,67,12,18228,0.0432398936938422,0.113504720946336,22.6716417910448,0,"NEDD4L"]
["negative regulation of potassium ion transmembrane transport","GO:1901380",1,67,12,18228,0.0432398936938422,0.113504720946336,22.6716417910448,0,"NEDD4L"]
["positive thymic T cell selection","GO:0045059",1,67,12,18228,0.0432398936938422,0.113504720946336,22.6716417910448,0,"NFATC3"]
["collagen biosynthetic process","GO:0032964",1,67,12,18228,0.0432398936938422,0.113504720946336,22.6716417910448,0,"TRAM2"]
["regulation of sodium ion transmembrane transport","GO:1902305",1,67,12,18228,0.0432398936938422,0.113504720946336,22.6716417910448,0,"NEDD4L"]
["phosphate ion transport","GO:0006817",1,67,12,18228,0.0432398936938422,0.113504720946336,22.6716417910448,0,"SLC17A8"]
["centriole-centriole cohesion","GO:0010457",1,67,13,18228,0.0467589388806292,0.118278116732482,20.9276693455798,0,"NIN"]
["cellular response to electrical stimulus","GO:0071257",1,67,13,18228,0.0467589388806292,0.118278116732482,20.9276693455798,0,"REST"]
["collateral sprouting","GO:0048668",1,67,13,18228,0.0467589388806292,0.118278116732482,20.9276693455798,0,"NIN"]
["postreplication repair","GO:0006301",1,67,13,18228,0.0467589388806292,0.118278116732482,20.9276693455798,0,"UBE2B"]
["endocytosis","GO:0006897",3,67,219,18228,0.0467725057886212,0.118278116732482,3.72684522592517,0,"MYO6, AAK1, AP3M2"]
["negative regulation by host of viral transcription","GO:0043922",1,67,13,18228,0.0467589388806292,0.118278116732482,20.9276693455798,0,"REST"]
["membrane repolarization during ventricular cardiac muscle cell action potential","GO:0098915",1,67,13,18228,0.0467589388806292,0.118278116732482,20.9276693455798,0,"KCNE1"]
["membrane protein proteolysis","GO:0033619",1,67,14,18228,0.0502652332037145,0.123867896109153,19.4328358208955,0,"CLPP"]
["actin crosslink formation","GO:0051764",1,67,14,18228,0.0502652332037145,0.123867896109153,19.4328358208955,0,"BAIAP2L2"]
["DNA catabolic process","GO:0006308",1,67,14,18228,0.0502652332037145,0.123867896109153,19.4328358208955,0,"DNASE1"]
["membrane repolarization","GO:0086009",1,67,14,18228,0.0502652332037145,0.123867896109153,19.4328358208955,0,"KCNE1"]
["dendrite self-avoidance","GO:0070593",1,67,14,18228,0.0502652332037145,0.123867896109153,19.4328358208955,0,"EMB"]
["sphingosine-1-phosphate receptor signaling pathway","GO:0003376",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"SPNS2"]
["G protein-coupled glutamate receptor signaling pathway","GO:0007216",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"HOMER2"]
["lymphocyte homeostasis","GO:0002260",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"SPNS2"]
["phosphate ion homeostasis","GO:0055062",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"SLC17A8"]
["cellular response to acidic pH","GO:0071468",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"KCNE1"]
["negative regulation of calcineurin-NFAT signaling cascade","GO:0070885",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"HOMER2"]
["positive regulation of programmed cell death","GO:0043068",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"REST"]
["regulation of short-term neuronal synaptic plasticity","GO:0048172",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"SLC4A10"]
["regulation of membrane repolarization","GO:0060306",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"NEDD4L"]
["regulation of store-operated calcium entry","GO:2001256",1,67,15,18228,0.0537588221668939,0.126046170420436,18.1373134328358,0,"HOMER2"]
["cerebral cortex neuron differentiation","GO:0021895",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"TOX"]
["sulfation","GO:0051923",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"CHSY1"]
["protein quality control for misfolded or incompletely synthesized proteins","GO:0006515",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"CLPP"]
["negative regulation of transcription by RNA polymerase II","GO:0000122",7,67,941,18228,0.0567917924782536,0.128589766456247,2.02382349675639,0,"PHF6, REST, IKZF5, NFATC3, WDTC1, NR2F1, PPM1A"]
["natural killer cell differentiation","GO:0001779",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"TOX"]
["locomotory exploration behavior","GO:0035641",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"SLC4A10"]
["potassium ion export across plasma membrane","GO:0097623",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"KCNE1"]
["regulation of osteoblast differentiation","GO:0045667",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"REST"]
["behavioral response to cocaine","GO:0048148",1,67,16,18228,0.0572397511140645,0.128589766456247,17.0037313432836,0,"HOMER2"]
["positive regulation of potassium ion transmembrane transport","GO:1901381",1,67,17,18228,0.0607080652297771,0.131488769085123,16.0035118525022,0,"KCNE1"]
["gastrulation with mouth forming second","GO:0001702",1,67,17,18228,0.0607080652297771,0.131488769085123,16.0035118525022,0,"ACVR2A"]
["protein ubiquitination","GO:0016567",5,67,575,18228,0.0600860998432217,0.131488769085123,2.36573653471772,0,"KLHL18, NEDD4L, UBE2B, WDTC1, UBE2G1"]
["cellular response to light stimulus","GO:0071482",1,67,17,18228,0.0607080652297771,0.131488769085123,16.0035118525022,0,"KCNE1"]
["ubiquitin-dependent protein catabolic process","GO:0006511",3,67,242,18228,0.0595961582271343,0.131488769085123,3.37264092759344,0,"NEDD4L, UBE2B, UBE2G1"]
["peptidyl-threonine dephosphorylation","GO:0035970",1,67,17,18228,0.0607080652297771,0.131488769085123,16.0035118525022,0,"PPM1A"]
["sterol biosynthetic process","GO:0016126",1,67,17,18228,0.0607080652297771,0.131488769085123,16.0035118525022,0,"CYB5R2"]
["regulation of multicellular organismal process","GO:0051239",1,67,17,18228,0.0607080652297771,0.131488769085123,16.0035118525022,0,"ACVR2A"]
["in utero embryonic development","GO:0001701",3,67,245,18228,0.0613795747552862,0.132349708066086,3.33134328358209,0,"GJB3, UBE2B, WDTC1"]
["proteasome-mediated ubiquitin-dependent protein catabolic process","GO:0043161",3,67,249,18228,0.0637962446148768,0.135925964946129,3.27782772882575,0,"NEDD4L, UBE2B, UBE2G1"]
["centrosome localization","GO:0051642",1,67,18,18228,0.0641638095397878,0.135925964946129,15.1144278606965,0,"NIN"]
["detection of mechanical stimulus involved in sensory perception of sound","GO:0050910",1,67,18,18228,0.0641638095397878,0.135925964946129,15.1144278606965,0,"REST"]
["ectopic germ cell programmed cell death","GO:0035234",1,67,18,18228,0.0641638095397878,0.135925964946129,15.1144278606965,0,"UBE2B"]
["melanosome assembly","GO:1903232",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"AP3S1"]
["intracellular calcium ion homeostasis","GO:0006874",2,67,114,18228,0.0659221626846947,0.137202499850027,4.77297721916732,0,"ATP2B1, NPTN"]
["calcineurin-NFAT signaling cascade","GO:0033173",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"NFATC3"]
["DNA damage response, signal transduction by p53 class mediator","GO:0030330",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"MYO6"]
["nervous system process","GO:0050877",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"REST"]
["cell surface receptor protein serine/threonine kinase signaling pathway","GO:0007178",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"ACVR2A"]
["cellular response to ATP","GO:0071318",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"CIB2"]
["protein O-linked mannosylation","GO:0035269",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"TMTC4"]
["chondroitin sulfate biosynthetic process","GO:0030206",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"CHSY1"]
["long-chain fatty-acyl-CoA biosynthetic process","GO:0035338",1,67,19,18228,0.0676070289116074,0.137202499850027,14.318931657502,0,"ACSL4"]
["positive regulation of canonical Wnt signaling pathway","GO:0090263",2,67,116,18228,0.0679514478800021,0.137324474167536,4.69068450849202,0,"UBE2B, PPM1A"]
["positive regulation of protein export from nucleus","GO:0046827",1,67,20,18228,0.0710377680550487,0.140619844141756,13.6029850746269,0,"PPM1A"]
["nerve development","GO:0021675",1,67,20,18228,0.0710377680550487,0.140619844141756,13.6029850746269,0,"SEMA3F"]
["neural retina development","GO:0003407",1,67,20,18228,0.0710377680550487,0.140619844141756,13.6029850746269,0,"SLC17A8"]
["barbed-end actin filament capping","GO:0051016",1,67,20,18228,0.0710377680550487,0.140619844141756,13.6029850746269,0,"TRIOBP"]
["cytoskeleton-dependent intracellular transport","GO:0030705",1,67,20,18228,0.0710377680550487,0.140619844141756,13.6029850746269,0,"CCDC88C"]
["activin receptor signaling pathway","GO:0032924",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"ACVR2A"]
["androgen metabolic process","GO:0008209",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"HSD17B4"]
["positive regulation of neuron projection development","GO:0010976",2,67,122,18228,0.0741616200096635,0.141583789549209,4.45999510643504,0,"NPTN, TOX"]
["actin filament-based movement","GO:0030048",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"MYO6"]
["negative regulation of fatty acid biosynthetic process","GO:0045717",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"WDTC1"]
["positive regulation of neural precursor cell proliferation","GO:2000179",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"TOX"]
["plasma membrane organization","GO:0007009",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"BAIAP2L2"]
["establishment of endothelial barrier","GO:0061028",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"MARVELD2"]
["male gonad development","GO:0008584",2,67,121,18228,0.0731141408595946,0.141583789549209,4.49685457012458,0,"ACVR2A, KCNE1"]
["chondrocyte development","GO:0002063",1,67,21,18228,0.0744560715227723,0.141583789549209,12.955223880597,0,"CHSY1"]
["regulation of dendrite morphogenesis","GO:0048814",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"NEDD4L"]
["regulation of ventricular cardiac muscle cell membrane repolarization","GO:0060307",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"KCNE1"]
["brain morphogenesis","GO:0048854",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"SLC4A10"]
["regulation of pH","GO:0006885",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"SLC4A10"]
["very long-chain fatty acid metabolic process","GO:0000038",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"HSD17B4"]
["inorganic anion transport","GO:0015698",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"SLC4A10"]
["regulation of cardiac conduction","GO:1903779",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"ATP2B1"]
["heart contraction","GO:0060047",1,67,22,18228,0.0778619837108304,0.143539458520348,12.3663500678426,0,"KCNE1"]
["negative regulation of ossification","GO:0030279",1,67,23,18228,0.0812555488592087,0.148099736222633,11.8286826735886,0,"CHSY1"]
["L-glutamate transmembrane transport","GO:0015813",1,67,23,18228,0.0812555488592087,0.148099736222633,11.8286826735886,0,"SLC17A8"]
["cellular response to glucocorticoid stimulus","GO:0071385",1,67,23,18228,0.0812555488592087,0.148099736222633,11.8286826735886,0,"REST"]
["positive regulation of cardiac muscle hypertrophy","GO:0010613",1,67,24,18228,0.0846368110523662,0.150847157705878,11.3358208955224,0,"NFATC3"]
["cardiac muscle cell action potential involved in contraction","GO:0086002",1,67,24,18228,0.0846368110523662,0.150847157705878,11.3358208955224,0,"KCNE1"]
["outer dynein arm assembly","GO:0036158",1,67,24,18228,0.0846368110523662,0.150847157705878,11.3358208955224,0,"NISCH"]
["transmission of nerve impulse","GO:0019226",1,67,24,18228,0.0846368110523662,0.150847157705878,11.3358208955224,0,"OTOA"]
["tRNA aminoacylation for protein translation","GO:0006418",1,67,24,18228,0.0846368110523662,0.150847157705878,11.3358208955224,0,"HARS2"]
["positive regulation of dendrite extension","GO:1903861",1,67,24,18228,0.0846368110523662,0.150847157705878,11.3358208955224,0,"NEDD4L"]
["cochlea morphogenesis","GO:0090103",1,67,25,18228,0.088005814219774,0.154010174884605,10.8823880597015,0,"MYO3A"]
["Rac protein signal transduction","GO:0016601",1,67,25,18228,0.088005814219774,0.154010174884605,10.8823880597015,0,"NISCH"]
["platelet dense granule organization","GO:0060155",1,67,25,18228,0.088005814219774,0.154010174884605,10.8823880597015,0,"AP3S1"]
["regulation of monoatomic ion transmembrane transport","GO:0034765",1,67,25,18228,0.088005814219774,0.154010174884605,10.8823880597015,0,"NEDD4L"]
["neuronal stem cell population maintenance","GO:0097150",1,67,25,18228,0.088005814219774,0.154010174884605,10.8823880597015,0,"REST"]
["sodium ion transmembrane transport","GO:0035725",2,67,136,18228,0.0893154389285745,0.155737750911558,4.00087796312555,0,"SLC17A8, SLC4A10"]
["blastocyst hatching","GO:0001835",1,67,26,18228,0.0913626021364513,0.157600488685378,10.4638346727899,0,"PHF6"]
["positive regulation of calcium ion transport","GO:0051928",1,67,26,18228,0.0913626021364513,0.157600488685378,10.4638346727899,0,"ATP2B1"]
["proximal/distal pattern formation","GO:0009954",1,67,26,18228,0.0913626021364513,0.157600488685378,10.4638346727899,0,"CHSY1"]
["regulation of cell size","GO:0008361",1,67,27,18228,0.0947072184234998,0.160503812275615,10.0762852404643,0,"WDTC1"]
["sodium ion transport","GO:0006814",2,67,140,18228,0.0938021633200506,0.160503812275615,3.8865671641791,0,"SLC17A8, SLC4A10"]
["regulation of potassium ion transmembrane transport","GO:1901379",1,67,27,18228,0.0947072184234998,0.160503812275615,10.0762852404643,0,"KCNE1"]
["response to light stimulus","GO:0009416",1,67,27,18228,0.0947072184234998,0.160503812275615,10.0762852404643,0,"SLC4A10"]
["lipid biosynthetic process","GO:0008610",1,67,27,18228,0.0947072184234998,0.160503812275615,10.0762852404643,0,"ACSL4"]
["positive regulation of lamellipodium assembly","GO:0010592",1,67,28,18228,0.0980397065486371,0.163809287762364,9.71641791044776,0,"CLRN1"]
["regulation of intracellular pH","GO:0051453",1,67,28,18228,0.0980397065486371,0.163809287762364,9.71641791044776,0,"SLC4A10"]
["negative regulation of neurogenesis","GO:0050768",1,67,28,18228,0.0980397065486371,0.163809287762364,9.71641791044776,0,"REST"]
["B cell homeostasis","GO:0001782",1,67,28,18228,0.0980397065486371,0.163809287762364,9.71641791044776,0,"SPNS2"]
["positive regulation of cytosolic calcium ion concentration","GO:0007204",2,67,144,18228,0.0983534025902394,0.163809287762364,3.77860696517413,0,"NPTN, CIB2"]
["non-canonical Wnt signaling pathway","GO:0035567",1,67,29,18228,0.101360109826727,0.167088508690475,9.38136901698405,0,"CCDC88C"]
["cell-cell junction organization","GO:0045216",1,67,29,18228,0.101360109826727,0.167088508690475,9.38136901698405,0,"MARVELD2"]
["Golgi to plasma membrane transport","GO:0006893",1,67,29,18228,0.101360109826727,0.167088508690475,9.38136901698405,0,"GGA1"]
["negative regulation of interleukin-2 production","GO:0032703",1,67,30,18228,0.10466847142031,0.170793485459492,9.06865671641791,0,"HOMER2"]
["negative regulation of microtubule depolymerization","GO:0007026",1,67,30,18228,0.10466847142031,0.170793485459492,9.06865671641791,0,"CCDC88C"]
["system development","GO:0048731",1,67,30,18228,0.10466847142031,0.170793485459492,9.06865671641791,0,"SEMA3F"]
["actin filament organization","GO:0007015",2,67,152,18228,0.107638384857594,0.173823383287605,3.57973291437549,0,"MYO6, CLRN1"]
["regulation of macromolecule metabolic process","GO:0060255",1,67,31,18228,0.107964834340127,0.173823383287605,8.77611940298507,0,"ACVR2A"]
["estrogen metabolic process","GO:0008210",1,67,31,18228,0.107964834340127,0.173823383287605,8.77611940298507,0,"HSD17B4"]
["positive regulation of filopodium assembly","GO:0051491",1,67,31,18228,0.107964834340127,0.173823383287605,8.77611940298507,0,"MYO3A"]
["face morphogenesis","GO:0060325",1,67,32,18228,0.111249241445651,0.175599292870096,8.50186567164179,0,"ANKRD11"]
["microtubule bundle formation","GO:0001578",1,67,32,18228,0.111249241445651,0.175599292870096,8.50186567164179,0,"CCDC88C"]
["protein localization to cell surface","GO:0034394",1,67,32,18228,0.111249241445651,0.175599292870096,8.50186567164179,0,"GGA1"]
["lysosome localization","GO:0032418",1,67,32,18228,0.111249241445651,0.175599292870096,8.50186567164179,0,"KLC2"]
["sperm axoneme assembly","GO:0007288",1,67,32,18228,0.111249241445651,0.175599292870096,8.50186567164179,0,"UBE2B"]
["intra-Golgi vesicle-mediated transport","GO:0006891",1,67,32,18228,0.111249241445651,0.175599292870096,8.50186567164179,0,"VTI1A"]
["long-chain fatty acid metabolic process","GO:0001676",1,67,33,18228,0.114521735445604,0.177858515177578,8.24423337856174,0,"ACSL4"]
["positive regulation of axonogenesis","GO:0050772",1,67,33,18228,0.114521735445604,0.177858515177578,8.24423337856174,0,"NIN"]
["protein export from nucleus","GO:0006611",1,67,33,18228,0.114521735445604,0.177858515177578,8.24423337856174,0,"PPM1A"]
["Golgi to plasma membrane protein transport","GO:0043001",1,67,33,18228,0.114521735445604,0.177858515177578,8.24423337856174,0,"GGA1"]
["cellular response to BMP stimulus","GO:0071773",1,67,33,18228,0.114521735445604,0.177858515177578,8.24423337856174,0,"ACVR2A"]
["positive regulation of erythrocyte differentiation","GO:0045648",1,67,34,18228,0.117782358898483,0.181174774993527,8.0017559262511,0,"ACVR2A"]
["bone morphogenesis","GO:0060349",1,67,34,18228,0.117782358898483,0.181174774993527,8.0017559262511,0,"CHSY1"]
["Wnt signaling pathway, planar cell polarity pathway","GO:0060071",1,67,34,18228,0.117782358898483,0.181174774993527,8.0017559262511,0,"CCDC88C"]
["regulation of primary metabolic process","GO:0080090",1,67,35,18228,0.121031154213082,0.184628686928284,7.77313432835821,0,"ACVR2A"]
["phosphorylation","GO:0016310",5,67,713,18228,0.121174521234505,0.184628686928284,1.90785204412719,0,"ACVR2A, AAK1, MYO3A, EPS8L1, CIB2"]
["fatty acid metabolic process","GO:0006631",2,67,163,18228,0.12076936574827,0.184628686928284,3.3381558465342,0,"HSD17B4, ACSL4"]
["extracellular matrix organization","GO:0030198",2,67,165,18228,0.123198483599711,0.187122225090128,3.29769335142469,0,"COL9A2, COL9A3"]
["negative regulation of insulin secretion","GO:0046676",1,67,36,18228,0.124268163649003,0.188155244647237,7.55721393034826,0,"REST"]
["cilium organization","GO:0044782",1,67,37,18228,0.127493429317183,0.191835907664172,7.35296490520371,0,"CCDC88C"]
["mesoderm development","GO:0007498",1,67,37,18228,0.127493429317183,0.191835907664172,7.35296490520371,0,"ACVR2A"]
["positive regulation of smoothened signaling pathway","GO:0045880",1,67,38,18228,0.130706993180398,0.194850239833741,7.15946582875098,0,"CHSY1"]
["T cell homeostasis","GO:0043029",1,67,38,18228,0.130706993180398,0.194850239833741,7.15946582875098,0,"SPNS2"]
["regulation of postsynapse organization","GO:0099175",1,67,38,18228,0.130706993180398,0.194850239833741,7.15946582875098,0,"SEMA3F"]
["protein polyubiquitination","GO:0000209",2,67,173,18228,0.133032465424455,0.197706710153882,3.1451988611854,0,"UBE2B, UBE2G1"]
["protein K11-linked ubiquitination","GO:0070979",1,67,39,18228,0.133908897053785,0.198398764653307,6.97588978185993,0,"UBE2B"]
["intracellular receptor signaling pathway","GO:0030522",1,67,40,18228,0.137099182605349,0.199454533730071,6.80149253731343,0,"NR2F1"]
["positive regulation of SMAD protein signal transduction","GO:0060391",1,67,40,18228,0.137099182605349,0.199454533730071,6.80149253731343,0,"ACVR2A"]
["regulation of heart rate by cardiac conduction","GO:0086091",1,67,40,18228,0.137099182605349,0.199454533730071,6.80149253731343,0,"KCNE1"]
["regulation of cytosolic calcium ion concentration","GO:0051480",1,67,40,18228,0.137099182605349,0.199454533730071,6.80149253731343,0,"ATP2B1"]
["positive regulation of cysteine-type endopeptidase activity involved in apoptotic process","GO:0043280",1,67,40,18228,0.137099182605349,0.199454533730071,6.80149253731343,0,"REST"]
["negative regulation of non-canonical NF-kappaB signal transduction","GO:1901223",1,67,40,18228,0.137099182605349,0.199454533730071,6.80149253731343,0,"PPM1A"]
["calcium ion homeostasis","GO:0055074",1,67,41,18228,0.140277891356473,0.202856950674181,6.63560247542774,0,"CIB2"]
["negative chemotaxis","GO:0050919",1,67,41,18228,0.140277891356473,0.202856950674181,6.63560247542774,0,"SEMA3F"]
["synaptic transmission, glutamatergic","GO:0035249",1,67,42,18228,0.143445064682426,0.206817809676454,6.47761194029851,0,"SLC17A8"]
["anatomical structure development","GO:0048856",1,67,43,18228,0.146600743812872,0.208873626140463,6.32696980215203,0,"NR2F1"]
["semaphorin-plexin signaling pathway","GO:0071526",1,67,43,18228,0.146600743812872,0.208873626140463,6.32696980215203,0,"SEMA3F"]
["protein monoubiquitination","GO:0006513",1,67,43,18228,0.146600743812872,0.208873626140463,6.32696980215203,0,"NEDD4L"]
["positive regulation of substrate adhesion-dependent cell spreading","GO:1900026",1,67,43,18228,0.146600743812872,0.208873626140463,6.32696980215203,0,"TRIOBP"]
["positive regulation of nitric oxide biosynthetic process","GO:0045429",1,67,44,18228,0.149744969832368,0.210252384968121,6.1831750339213,0,"NFATC3"]
["axon guidance","GO:0007411",2,67,185,18228,0.148104003055033,0.210252384968121,2.94118596208148,0,"EMB, SEMA3F"]
["sphingolipid biosynthetic process","GO:0030148",1,67,44,18228,0.149744969832368,0.210252384968121,6.1831750339213,0,"SPNS2"]
["placenta development","GO:0001890",1,67,44,18228,0.149744969832368,0.210252384968121,6.1831750339213,0,"GJB3"]
["cellular response to stress","GO:0033554",1,67,44,18228,0.149744969832368,0.210252384968121,6.1831750339213,0,"REST"]
["skeletal system morphogenesis","GO:0048705",1,67,45,18228,0.152877783680874,0.212183820453627,6.04577114427861,0,"ANKRD11"]
["neural crest cell migration","GO:0001755",1,67,45,18228,0.152877783680874,0.212183820453627,6.04577114427861,0,"SEMA3F"]
["transmembrane transport","GO:0055085",4,67,563,18228,0.152520115140335,0.212183820453627,1.93292860740701,0,"GJB3, SPNS2, SLC17A8, SLC4A10"]
["membrane fusion","GO:0061025",1,67,45,18228,0.152877783680874,0.212183820453627,6.04577114427861,0,"VTI1A"]
["proteolysis involved in protein catabolic process","GO:0051603",1,67,46,18228,0.155999226154249,0.214055756342336,5.91434133679429,0,"CLPP"]
["cell motility","GO:0048870",1,67,46,18228,0.155999226154249,0.214055756342336,5.91434133679429,0,"CLRN1"]
["embryonic skeletal system development","GO:0048706",1,67,46,18228,0.155999226154249,0.214055756342336,5.91434133679429,0,"ACVR2A"]
["cytoplasmic microtubule organization","GO:0031122",1,67,46,18228,0.155999226154249,0.214055756342336,5.91434133679429,0,"CCDC88C"]
["positive regulation of stem cell population maintenance","GO:1902459",1,67,47,18228,0.159109337904753,0.217704844781857,5.78850428707526,0,"REST"]
["regulation of G protein-coupled receptor signaling pathway","GO:0008277",1,67,48,18228,0.162208159441543,0.221317912458377,5.66791044776119,0,"HOMER2"]
["fatty acid beta-oxidation","GO:0006635",1,67,49,18228,0.16529573113117,0.222195959056472,5.55223880597015,0,"HSD17B4"]
["G2/M transition of mitotic cell cycle","GO:0000086",1,67,50,18228,0.168372093198072,0.222195959056472,5.44119402985075,0,"USH1C"]
["positive regulation of Notch signaling pathway","GO:0045747",1,67,50,18228,0.168372093198072,0.222195959056472,5.44119402985075,0,"AAK1"]
["endoplasmic reticulum unfolded protein response","GO:0030968",1,67,50,18228,0.168372093198072,0.222195959056472,5.44119402985075,0,"TMTC4"]
["cilium movement","GO:0003341",1,67,49,18228,0.16529573113117,0.222195959056472,5.55223880597015,0,"CCDC88C"]
["bicellular tight junction assembly","GO:0070830",1,67,50,18228,0.168372093198072,0.222195959056472,5.44119402985075,0,"MARVELD2"]
["positive regulation of protein phosphorylation","GO:0001934",2,67,200,18228,0.167403286020851,0.222195959056472,2.72059701492537,0,"ACVR2A, NPTN"]
["positive regulation of transcription elongation by RNA polymerase II","GO:0032968",1,67,50,18228,0.168372093198072,0.222195959056472,5.44119402985075,0,"MED28"]
["positive regulation of actin filament polymerization","GO:0030838",1,67,50,18228,0.168372093198072,0.222195959056472,5.44119402985075,0,"BAIAP2L2"]
["monoatomic anion transmembrane transport","GO:0098656",1,67,49,18228,0.16529573113117,0.222195959056472,5.55223880597015,0,"SLC4A10"]
["synaptic vesicle endocytosis","GO:0048488",1,67,49,18228,0.16529573113117,0.222195959056472,5.55223880597015,0,"AP3M2"]
["sphingolipid metabolic process","GO:0006665",1,67,50,18228,0.168372093198072,0.222195959056472,5.44119402985075,0,"SPNS2"]
["skin development","GO:0043588",1,67,52,18228,0.174491348653847,0.229643927519913,5.23191733639495,0,"GJB3"]
["regulation of protein phosphorylation","GO:0001932",1,67,53,18228,0.17753432178546,0.231129588739561,5.13320191495354,0,"CCDC88C"]
["protein destabilization","GO:0031648",1,67,53,18228,0.17753432178546,0.231129588739561,5.13320191495354,0,"CCDC88C"]
["cellular response to cAMP","GO:0071320",1,67,53,18228,0.17753432178546,0.231129588739561,5.13320191495354,0,"KCNE1"]
["RNA polymerase II preinitiation complex assembly","GO:0051123",1,67,53,18228,0.17753432178546,0.231129588739561,5.13320191495354,0,"MED28"]
["response to UV","GO:0009411",1,67,54,18228,0.180566244780803,0.234444882336366,5.03814262023217,0,"UBE2B"]
["adult locomotory behavior","GO:0008344",1,67,56,18228,0.186597098308428,0.241625733198313,4.85820895522388,0,"OTOG"]
["regulation of alternative mRNA splicing, via spliceosome","GO:0000381",1,67,57,18228,0.189596107466106,0.244199786416345,4.77297721916732,0,"REST"]
["neurotransmitter transport","GO:0006836",1,67,57,18228,0.189596107466106,0.244199786416345,4.77297721916732,0,"SLC17A8"]
["regulation of signal transduction","GO:0009966",1,67,59,18228,0.195561486095329,0.249884121121809,4.61118138122945,0,"ACVR2A"]
["inner ear development","GO:0048839",1,67,59,18228,0.195561486095329,0.249884121121809,4.61118138122945,0,"GRXCR1"]
["positive regulation of transcription initiation by RNA polymerase II","GO:0060261",1,67,59,18228,0.195561486095329,0.249884121121809,4.61118138122945,0,"MED28"]
["positive regulation of insulin secretion","GO:0032024",1,67,60,18228,0.198527933364392,0.253005255448552,4.53432835820896,0,"ACSL4"]
["dephosphorylation","GO:0016311",1,67,62,18228,0.204428537278612,0.259157437022493,4.38805970149254,0,"PPM1A"]
["glucose metabolic process","GO:0006006",1,67,62,18228,0.204428537278612,0.259157437022493,4.38805970149254,0,"WDTC1"]
["negative regulation of neuron differentiation","GO:0045665",1,67,63,18228,0.207362770901993,0.262189053260897,4.318407960199,0,"REST"]
["endocytic recycling","GO:0032456",1,67,64,18228,0.210286343395776,0.265191393890756,4.2509328358209,0,"VTI1A"]
["monoatomic ion transport","GO:0006811",2,67,237,18228,0.216562634266326,0.27028359780526,2.29586245985264,0,"SLC17A8, SLC4A10"]
["response to ischemia","GO:0002931",1,67,66,18228,0.216101657463823,0.27028359780526,4.12211668928087,0,"REST"]
["long-term synaptic potentiation","GO:0060291",1,67,66,18228,0.216101657463823,0.27028359780526,4.12211668928087,0,"NPTN"]
["protein stabilization","GO:0050821",2,67,236,18228,0.215213411883415,0.27028359780526,2.30559069061472,0,"AAK1, UBE2B"]
["synapse organization","GO:0050808",1,67,67,18228,0.218993474937115,0.272613011326357,4.06059255959011,0,"NPTN"]
["negative regulation of canonical NF-kappaB signal transduction","GO:0043124",1,67,69,18228,0.224745619507859,0.279054329620298,3.94289422452953,0,"PPM1A"]
["cellular response to growth factor stimulus","GO:0071363",1,67,70,18228,0.22760602170473,0.280443133886185,3.8865671641791,0,"ACVR2A"]
["protein autoubiquitination","GO:0051865",1,67,70,18228,0.22760602170473,0.280443133886185,3.8865671641791,0,"UBE2B"]
["insulin receptor signaling pathway","GO:0008286",1,67,70,18228,0.22760602170473,0.280443133886185,3.8865671641791,0,"AP3S1"]
["cellular response to retinoic acid","GO:0071300",1,67,71,18228,0.230456027021713,0.283232216415998,3.83182678158503,0,"GJB3"]
["cellular response to xenobiotic stimulus","GO:0071466",1,67,72,18228,0.23329567267846,0.285994441379939,3.77860696517413,0,"REST"]
["negative regulation of BMP signaling pathway","GO:0030514",1,67,73,18228,0.23612499576342,0.288000941802353,3.72684522592517,0,"PPM1A"]
["response to nutrient levels","GO:0031667",1,67,73,18228,0.23612499576342,0.288000941802353,3.72684522592517,0,"CHSY1"]
["cellular response to transforming growth factor beta stimulus","GO:0071560",1,67,74,18228,0.238944033234301,0.290705209199415,3.67648245260186,0,"PPM1A"]
["negative regulation of neuron projection development","GO:0010977",1,67,75,18228,0.24175282191852,0.291188561063953,3.62746268656716,0,"NR2F1"]
["macroautophagy","GO:0016236",1,67,75,18228,0.24175282191852,0.291188561063953,3.62746268656716,0,"VTI1A"]
["post-embryonic development","GO:0009791",1,67,75,18228,0.24175282191852,0.291188561063953,3.62746268656716,0,"SLC4A10"]
["hematopoietic progenitor cell differentiation","GO:0002244",1,67,75,18228,0.24175282191852,0.291188561063953,3.62746268656716,0,"REST"]
["bone development","GO:0060348",1,67,76,18228,0.244551398513653,0.293826680303718,3.57973291437549,0,"SPNS2"]
["BMP signaling pathway","GO:0030509",1,67,78,18228,0.250118061580489,0.299027286493505,3.48794489092997,0,"ACVR2A"]
["positive regulation of osteoblast differentiation","GO:0045669",1,67,78,18228,0.250118061580489,0.299027286493505,3.48794489092997,0,"ACVR2A"]
["response to xenobiotic stimulus","GO:0009410",2,67,263,18228,0.251863899601222,0.300371021005902,2.06889506838431,0,"MYO6, UBE2B"]
["regulation of blood pressure","GO:0008217",1,67,82,18228,0.261130443031649,0.309891901681293,3.31780123771387,0,"ATP2B1"]
["determination of left/right symmetry","GO:0007368",1,67,82,18228,0.261130443031649,0.309891901681293,3.31780123771387,0,"ACVR2A"]
["microtubule-based movement","GO:0007018",1,67,83,18228,0.263858551723199,0.312361961966434,3.27782772882575,0,"KLC2"]
["cartilage development","GO:0051216",1,67,85,18228,0.26928503526877,0.318006533092459,3.20070237050044,0,"CHSY1"]
["positive regulation of neuron differentiation","GO:0045666",1,67,88,18228,0.277350957351819,0.325146874759535,3.09158751696065,0,"REST"]
["cell communication","GO:0007154",1,67,88,18228,0.277350957351819,0.325146874759535,3.09158751696065,0,"GJB3"]
["positive regulation of cell growth","GO:0030307",1,67,88,18228,0.277350957351819,0.325146874759535,3.09158751696065,0,"ACSL4"]
["protein catabolic process","GO:0030163",1,67,89,18228,0.280020058005481,0.327481084786071,3.05685057856784,0,"GGA1"]
["regulation of membrane potential","GO:0042391",1,67,90,18228,0.282679446952701,0.329792688111485,3.0228855721393,0,"NEDD4L"]
["regulation of protein stability","GO:0031647",1,67,93,18228,0.290599690974353,0.338216025880994,2.92537313432836,0,"NEDD4L"]
["cellular response to insulin stimulus","GO:0032869",1,67,96,18228,0.29843377520857,0.346498830350335,2.8339552238806,0,"WDTC1"]
["regulation of protein localization","GO:0032880",1,67,98,18228,0.303609087802812,0.351662324721243,2.77611940298507,0,"AAK1"]
["positive regulation of JNK cascade","GO:0046330",1,67,99,18228,0.306182622889255,0.353794753242847,2.74807779285391,0,"CCDC88C"]
["spermatogenesis","GO:0007283",3,67,540,18228,0.319119692929632,0.367863512374731,1.51144278606965,0,"ACVR2A, GJB3, UBE2B"]
["protein import into nucleus","GO:0006606",1,67,106,18228,0.32393690529429,0.372527441088433,2.56660095747677,0,"NFATC3"]
["cell-matrix adhesion","GO:0007160",1,67,107,18228,0.326436421205629,0.374510193449688,2.54261403264054,0,"OTOA"]
["protein phosphorylation","GO:0006468",3,67,558,18228,0.337335361263377,0.386097107796708,1.46268656716418,0,"ACVR2A, AAK1, MYO3A"]
["chloride transmembrane transport","GO:1902476",1,67,112,18228,0.338798096750048,0.386854564374168,2.42910447761194,0,"SLC17A8"]
["positive regulation of apoptotic process","GO:0043065",2,67,328,18228,0.340196678140288,0.387535366843771,1.65890061885693,0,"REST, NFATC3"]
["anterior/posterior pattern specification","GO:0009952",1,67,114,18228,0.343679949861145,0.390582154783372,2.38648860958366,0,"ACVR2A"]
["modulation of chemical synaptic transmission","GO:0050804",1,67,115,18228,0.346107544172689,0.392417708533823,2.36573653471772,0,"NPTN"]
["calcium-mediated signaling","GO:0019722",1,67,118,18228,0.353337380086738,0.399676708622704,2.30559069061472,0,"HOMER2"]
["calcium ion transport","GO:0006816",1,67,119,18228,0.355729781827997,0.401442721081594,2.28621597892889,0,"ATP2B1"]
["chromatin remodeling","GO:0006338",3,67,580,18228,0.35957851075522,0.404840141479653,1.40720535254761,0,"AAK1, REST, MYO3A"]
["small GTPase-mediated signal transduction","GO:0007264",1,67,121,18228,0.3604884585914,0.404920756975922,2.24842728506229,0,"CCDC88C"]
["endoplasmic reticulum to Golgi vesicle-mediated transport","GO:0006888",1,67,127,18228,0.374557714745303,0.41974797267281,2.14220237395699,0,"VTI1A"]
["nervous system development","GO:0007399",3,67,596,18228,0.375704467365205,0.420058466984708,1.369428027647,0,"NPTN, TOX, NR2F1"]
["negative regulation of transforming growth factor beta receptor signaling pathway","GO:0030512",1,67,130,18228,0.381477555849501,0.42552808192912,2.09276693455798,0,"PPM1A"]
["osteoblast differentiation","GO:0001649",1,67,135,18228,0.392843401744222,0.437196689037924,2.01525704809287,0,"HSD17B4"]
["potassium ion transport","GO:0006813",1,67,138,18228,0.399563890910742,0.443653699562962,1.97144711226476,0,"KCNE1"]
["anatomical structure morphogenesis","GO:0009653",1,67,139,18228,0.401787728351813,0.445099708242949,1.95726403951466,0,"MPZL2"]
["calcium ion transmembrane transport","GO:0070588",1,67,144,18228,0.412785787893838,0.456236923461611,1.88930348258706,0,"ATP2B1"]
["skeletal system development","GO:0001501",1,67,148,18228,0.421440614861546,0.464739308169239,1.83824122630093,0,"COL9A2"]
["protein-containing complex assembly","GO:0065003",1,67,149,18228,0.423584612583022,0.464980381539999,1.82590403686267,0,"USH1C"]
["negative regulation of canonical Wnt signaling pathway","GO:0090090",1,67,149,18228,0.423584612583022,0.464980381539999,1.82590403686267,0,"CCDC88C"]
["protein autophosphorylation","GO:0046777",1,67,150,18228,0.425720783331234,0.466265619838971,1.81373134328358,0,"MYO3A"]
["potassium ion transmembrane transport","GO:0071805",1,67,155,18228,0.43628521396766,0.47574305271491,1.75522388059701,0,"KCNE1"]
["cell adhesion","GO:0007155",3,67,657,18228,0.436344042138106,0.47574305271491,1.24228174197506,0,"MPZL2, EMB, NPTN"]
["protein dephosphorylation","GO:0006470",1,67,159,18228,0.444598716998722,0.482564450135692,1.71106730498451,0,"PPM1A"]
["peptidyl-serine phosphorylation","GO:0018105",1,67,159,18228,0.444598716998722,0.482564450135692,1.71106730498451,0,"MYO3A"]
["chromatin organization","GO:0006325",2,67,413,18228,0.450478043930047,0.487849540848011,1.31748039463698,0,"UBE2B, TOX"]
["cell division","GO:0051301",2,67,417,18228,0.455429954235258,0.492108876724004,1.30484269300977,0,"TRIOBP, KLHL18"]
["positive regulation of transcription by RNA polymerase II","GO:0045944",5,67,1219,18228,0.467513826694885,0.504038344405423,1.11591345977251,0,"ACVR2A, REST, TOX, NFATC3, NR2F1"]
["proton transmembrane transport","GO:1902600",1,67,171,18228,0.468821307216778,0.504322252529407,1.59099240638911,0,"SLC4A10"]
["response to hypoxia","GO:0001666",1,67,174,18228,0.474712491856588,0.509524741259404,1.56356150283067,0,"REST"]
["protein glycosylation","GO:0006486",1,67,182,18228,0.490109482231193,0.524884434407243,1.49483352468427,0,"TMTC4"]
["negative regulation of cell migration","GO:0030336",1,67,185,18228,0.495767998910849,0.52976978644677,1.47059298104074,0,"NISCH"]
["lipid transport","GO:0006869",1,67,191,18228,0.506900093162731,0.540469635756289,1.42439634289287,0,"SPNS2"]
["apoptotic process","GO:0006915",3,67,745,18228,0.519783968860436,0.552986028545354,1.0955424221176,0,"UBE2B, NISCH, DNASE1"]
["cell-cell adhesion","GO:0098609",1,67,205,18228,0.531942129240588,0.564677029501547,1.32712049508555,0,"MPZL2"]
["lipid metabolic process","GO:0006629",2,67,496,18228,0.547791831903321,0.580226874581807,1.09701492537313,0,"HSD17B4, ACSL4"]
["positive regulation of canonical NF-kappaB signal transduction","GO:0043123",1,67,218,18228,0.554071511465952,0.585594179514343,1.24798028207586,0,"PPM1A"]
["positive regulation of DNA-templated transcription","GO:0045893",3,67,787,18228,0.557301956820399,0.587722369310595,1.0370763716361,0,"REST, NFATC3, PPM1A"]
["autophagy","GO:0006914",1,67,223,18228,0.562305550260631,0.59170714765988,1.21999866140151,0,"VTI1A"]
["Wnt signaling pathway","GO:0016055",1,67,227,18228,0.568784786330153,0.597224025646661,1.19850088763232,0,"CCDC88C"]
["neuron differentiation","GO:0030182",1,67,232,18228,0.576751097279052,0.604275010815146,1.17267112712301,0,"ACSL4"]
["actin cytoskeleton organization","GO:0030036",1,67,234,18228,0.579896871113607,0.60625581980059,1.16264829697666,0,"NISCH"]
["cell-cell signaling","GO:0007267",1,67,236,18228,0.583019610570339,0.608204042992384,1.15279534530736,0,"GJB3"]
["cilium assembly","GO:0060271",1,67,237,18228,0.584572394368237,0.608509626034178,1.14793122992632,0,"ELMOD1"]
["regulation of cell cycle","GO:0051726",1,67,263,18228,0.623004277560875,0.647120572176134,1.03444753419216,0,"PPM1A"]
["positive regulation of cell migration","GO:0030335",1,67,284,18228,0.651469868400773,0.675235936561316,0.957956695396258,0,"SEMA3F"]
["translation","GO:0006412",1,67,310,18228,0.683793574361667,0.707221191470418,0.877611940298507,0,"HARS2"]
["negative regulation of gene expression","GO:0010629",1,67,325,18228,0.701079018343981,0.72354949970116,0.837106773823192,0,"REST"]
["regulation of gene expression","GO:0010468",1,67,339,18228,0.716370609659525,0.737754806962794,0.802535992603355,0,"REST"]
["DNA damage response","GO:0006974",1,67,344,18228,0.721642969409433,0.741603306861184,0.790871225269004,0,"UBE2B"]
["cell differentiation","GO:0030154",3,67,1035,18228,0.740800557073694,0.759674456616973,0.788578844905905,0,"NEDD4L, USH1C, NR2F1"]
["regulation of DNA-templated transcription","GO:0006355",4,67,1379,18228,0.75607241678876,0.773692748535956,0.789150693234336,0,"REST, NFATC3, NR2F1, EWSR1"]
["DNA repair","GO:0006281",1,67,416,18228,0.787674423098644,0.804327159316374,0.653989667049369,0,"UBE2B"]
["signal transduction","GO:0007165",4,67,1487,18228,0.806861784404387,0.821105463171727,0.731835108251614,0,"GPR152, CABP2, SEMA3F, NR2F1"]
["inflammatory response","GO:0006954",1,67,442,18228,0.807505372684411,0.821105463171727,0.6155196866347,0,"NFATC3"]
["negative regulation of cell population proliferation","GO:0008285",1,67,452,18228,0.814636740440412,0.826616692505713,0.601901994452516,0,"REST"]
["negative regulation of apoptotic process","GO:0043066",1,67,518,18228,0.855594193441475,0.866356384553946,0.525211778943122,0,"UBE2B"]
["positive regulation of gene expression","GO:0010628",1,67,526,18228,0.859908097962597,0.868902952543796,0.517223767096079,0,"REST"]
["innate immune response","GO:0045087",1,67,578,18228,0.885012182852221,0.892402681247647,0.470691525073594,0,"CCDC92"]
["proteolysis","GO:0006508",1,67,589,18228,0.889724864280809,0.895285644682564,0.461901021209741,0,"CLPP"]
["negative regulation of DNA-templated transcription","GO:0045892",1,67,616,18228,0.90050071853705,0.904245004269013,0.441655359565807,0,"REST"]
["regulation of transcription by RNA polymerase II","GO:0006357",3,67,1625,18228,0.9451732333485,0.947134173666651,0.502264064293915,0,"IKZF5, TOX, NFATC3"]
["G protein-coupled receptor signaling pathway","GO:0007186",1,67,942,18228,0.971611670546076,0.971611670546076,0.2888107234528,0,"GPR152"]

{"sheet":"Supplementary Table S16.","index":16,"n_rows":191,"n_cols":11,"rows_kept":191}
["Supplementary Table S16.- Active biochemical pathways according to Gene Ontology - Cellular Component in Homosapiens."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["stereocilium","GO:0032420",8,67,53,19099,{"v":1.16491335856138E-11,"d":"1.16E-11"},{"v":2.1900371140954e-09,"d":"2.19E-09"},43.0278794705717,0,"TPRN, CLRN1, GRXCR1, USH1C, MYO3A, HOMER2, EPS8L2, CIB2"]
["stereocilium tip","GO:0032426",4,67,21,19099,{"v":7.91348734557635e-07,"d":"7.91E-07"},{"v":7.43867810484177e-05,"d":"7.44E-05"},54.2970859985785,0,"USH1C, MYO3A, HOMER2, EPS8L2"]
["microvillus","GO:0005902",5,67,75,19099,{"v":6.51592477198723e-06,"d":"6.52E-06"},0.0004083312857112,19.0039800995025,0,"MYO6, TPRN, CLRN1, GRXCR1, USH1C"]
["apical part of cell","GO:0045177",5,67,95,19099,{"v":2.07235098184262e-05,"d":"2.07E-05"},9.74004961466032E-4,15.0031421838178,0,"MYO6, MPDZ, USH1C, HOMER2, NIN"]
["plasma membrane","GO:0005886",34,67,5399,19099,{"v":8.26620420963379e-05,"d":"8.27E-05"},0.00259007731901859,1.7951527784305,0,"ACVR2A, GJB3, ATP2B1, KCNE1, MYO6, MPZL2, NEDD4L, ACSL4, GPR152, AAK1, EMB, CLRN1, CABP2, KLC2, SPNS2, MPDZ, SEMA3F, USH1C, OTOG, SLC17A8, MARVELD2, UBE2B, NPTN, BAIAP2L2, HOMER2, NISCH, OTOA, EPS8L1, EPS8L2, EWSR1, CIB2, SLC4A10, NIN, PPM1A"]
["collagen type IX trimer","GO:0005594",2,67,4,19099,{"v":7.24099992798424e-05,"d":"7.24E-05"},0.00259007731901859,142.529850746269,0,"COL9A2, COL9A3"]
["basal dendrite","GO:0097441",2,67,6,19099,0.000180204898815832,0.00483978871105378,95.0199004975124,0,"SLC17A8, SLC4A10"]
["AP-type membrane coat adaptor complex","GO:0030119",2,67,7,19099,0.000251714951622781,0.00591530136313535,81.4456289978678,0,"AP3S1, AP3M2"]
["stereocilium base","GO:0120044",2,67,8,19099,0.000334859308974068,0.00699483889856943,71.2649253731343,0,"TRIOBP, TPRN"]
["AP-3 adaptor complex","GO:0030123",2,67,13,19099,0.000922307480105985,0.0173393806259925,43.8553386911596,0,"AP3S1, AP3M2"]
["synaptic vesicle","GO:0008021",4,67,140,19099,1.48244556482615E-3,0.0214384435528705,8.14456289978678,0,"AP3S1, SLC17A8, AP3M2, VTI1A"]
["cytoplasmic vesicle","GO:0031410",9,67,761,19099,0.00130319654166151,0.0214384435528705,3.37127110832173,0,"ATP2B1, MYO6, AP3S1, SLC17A8, MARVELD2, BAIAP2L2, DNASE1, AP3M2, VTI1A"]
["apical dendrite","GO:0097440",2,67,16,19099,1.40932568885487E-3,0.0214384435528705,35.6324626865672,0,"SLC17A8, SLC4A10"]
["synapse","GO:0045202",10,67,961,19099,1.81170393152667E-3,0.0243285956519296,2.96628201344992,0,"ATP2B1, AAK1, EMB, MPDZ, USH1C, SLC17A8, NPTN, ELMOD1, HOMER2, SLC4A10"]
["photoreceptor inner segment","GO:0001917",3,67,71,19099,0.00198892513321889,0.0249278616696767,12.044776119403,0,"USH1C, MYO3A, CIB2"]
["clathrin-coated vesicle","GO:0030136",3,67,78,19099,0.00260154730841158,0.030568180873836,10.9638346727899,0,"MYO6, AAK1, VTI1A"]
["apical plasma membrane","GO:0016324",6,67,405,19099,0.0029402332804113,0.0325155209833721,4.22310668877833,0,"KCNE1, MPDZ, OTOG, MARVELD2, OTOA, SLC4A10"]
["kinesin I complex","GO:0016938",1,67,1,19099,0.00350803707000367,0.0366394982867049,285.059701492537,0,"KLC2"]
["ruffle membrane","GO:0032587",3,67,102,19099,0.0055312176278258,0.0528126802341514,8.38410886742757,0,"MYO6, EPS8L1, EPS8L2"]
["filamentous actin","GO:0031941",2,67,32,19099,5.61837023767569E-3,0.0528126802341514,17.8162313432836,0,"MYO6, MYO3A"]
["cell projection","GO:0042995",9,67,976,19099,6.82038557286062E-3,0.0548642817181927,2.62862429655004,0,"ATP2B1, MYO6, TPRN, AAK1, USH1C, MYO3A, HOMER2, EPS8L2, SLC4A10"]
["endopeptidase Clp complex","GO:0009368",1,67,2,19099,0.00700395085764162,0.0548642817181927,142.529850746269,0,"CLPP"]
["pericellular basket","GO:1990030",1,67,2,19099,0.00700395085764162,0.0548642817181927,142.529850746269,0,"SLC17A8"]
["CA3 pyramidal cell dendrite","GO:0097442",1,67,2,19099,0.00700395085764162,0.0548642817181927,142.529850746269,0,"SLC4A10"]
["glial limiting end-foot","GO:0097451",1,67,3,19099,0.0104877826266387,0.073026041992892,95.0199004975124,0,"SLC17A8"]
["zymogen granule","GO:0042588",1,67,3,19099,0.0104877826266387,0.073026041992892,95.0199004975124,0,"DNASE1"]
["inhibin-betaglycan-ActRII complex","GO:0034673",1,67,3,19099,0.0104877826266387,0.073026041992892,95.0199004975124,0,"ACVR2A"]
["presynapse","GO:0098793",4,67,247,19099,0.0110752186890159,0.0743621826262493,4.61635144117469,0,"AAK1, AP3S1, AP3M2, SLC4A10"]
["multivesicular body","GO:0005771",2,67,48,19099,0.0123253596971592,0.0747473426795463,11.8774875621891,0,"NEDD4L, SLC17A8"]
["synaptic vesicle membrane","GO:0030672",3,67,136,19099,0.012141922353791,0.0747473426795463,6.28808165057068,0,"ATP2B1, SLC17A8, VTI1A"]
["immunological synapse","GO:0001772",2,67,47,19099,0.011838364715779,0.0747473426795463,12.1302000635122,0,"ATP2B1, NPTN"]
["cytoplasmic vesicle membrane","GO:0030659",3,67,144,19099,0.0141486079028609,0.0759982367353672,5.93874378109453,0,"AP3S1, BAIAP2L2, AP3M2"]
["muscle tendon junction","GO:0005927",1,67,4,19099,0.013959573502425,0.0759982367353672,71.2649253731343,0,"CIB2"]
["HULC complex","GO:0033503",1,67,4,19099,0.013959573502425,0.0759982367353672,71.2649253731343,0,"UBE2B"]
["tricellular tight junction","GO:0061689",1,67,4,19099,0.013959573502425,0.0759982367353672,71.2649253731343,0,"MARVELD2"]
["myosin complex","GO:0016459",2,67,56,19099,0.0165278394092954,0.0863120502485425,10.1807036247335,0,"MYO6, MYO3A"]
["glutamatergic synapse","GO:0098978",6,67,593,19099,0.0176073183913679,0.0894642123669505,2.88424655810324,0,"ATP2B1, SEMA3F, SLC17A8, ELMOD1, HOMER2, AP3M2"]
["intracellular membrane-bounded organelle","GO:0043231",8,67,962,19099,0.0189306716533869,0.0936570071272826,2.37055884817079,0,"GJB3, ATP2B1, CCDC92, AAK1, AP3S1, NISCH, GGA1, VTI1A"]
["axon terminus","GO:0043679",2,67,63,19099,0.0206343147596083,0.095652822712922,9.04951433309642,0,"SLC17A8, SLC4A10"]
["axon cytoplasm","GO:1904115",2,67,65,19099,0.02187803923753,0.095652822712922,8.77106773823192,0,"AP3S1, AP3M2"]
["peroxisomal membrane","GO:0005778",2,67,65,19099,0.02187803923753,0.095652822712922,8.77106773823192,0,"HSD17B4, ACSL4"]
["stereocilia ankle link complex","GO:0002142",1,67,6,19099,0.0208671963873472,0.095652822712922,47.5099502487562,0,"USH1C"]
["activin receptor complex","GO:0048179",1,67,6,19099,0.0208671963873472,0.095652822712922,47.5099502487562,0,"ACVR2A"]
["bounding membrane of organelle","GO:0098588",1,67,7,19099,0.0243031099599679,0.0993257537494341,40.7228144989339,0,"VTI1A"]
["intracellular organelle","GO:0043229",1,67,7,19099,0.0243031099599679,0.0993257537494341,40.7228144989339,0,"HOMER2"]
["unconventional myosin complex","GO:0016461",1,67,7,19099,0.0243031099599679,0.0993257537494341,40.7228144989339,0,"MYO6"]
["clathrin-coated pit","GO:0005905",2,67,72,19099,0.0264675824826147,0.105870329930459,7.91832504145937,0,"MYO6, AAK1"]
["early endosome","GO:0005769",4,67,327,19099,0.0278348291495964,0.106439940345359,3.48696882559679,0,"AP3S1, NISCH, GGA1, AP3M2"]
["paranodal junction","GO:0033010",1,67,9,19099,0.0311393442499721,0.106439940345359,31.6733001658375,0,"MARVELD2"]
["dendrite","GO:0030425",5,67,494,19099,0.0295404404859027,0.106439940345359,2.88521965073418,0,"MPDZ, SLC17A8, HOMER2, SLC4A10, NIN"]
["ciliary transition fiber","GO:0097539",1,67,9,19099,0.0311393442499721,0.106439940345359,31.6733001658375,0,"NIN"]
["photoreceptor ribbon synapse","GO:0098684",1,67,9,19099,0.0311393442499721,0.106439940345359,31.6733001658375,0,"ATP2B1"]
["photoreceptor outer segment","GO:0001750",2,67,78,19099,0.0306829605492475,0.106439940345359,7.30922311519326,0,"USH1C, CIB2"]
["clathrin complex","GO:0071439",1,67,8,19099,0.0277271457672528,0.106439940345359,35.6324626865672,0,"BAIAP2L2"]
["kinocilium","GO:0060091",1,67,9,19099,0.0311393442499721,0.106439940345359,31.6733001658375,0,"GRXCR1"]
["clathrin adaptor complex","GO:0030131",1,67,10,19099,0.0345397457133168,0.106450363837763,28.5059701492537,0,"AP3M2"]
["centriolar subdistal appendage","GO:0120103",1,67,10,19099,0.0345397457133168,0.106450363837763,28.5059701492537,0,"NIN"]
["cell junction","GO:0030054",3,67,202,19099,0.0340708407985298,0.106450363837763,4.23355992315649,0,"GJB3, CCDC88C, MARVELD2"]
["cilium","GO:0005929",4,67,344,19099,0.0326618561437771,0.106450363837763,3.31464769177369,0,"GRXCR1, USH1C, ELMOD1, CIB2"]
["autophagosome","GO:0005776",2,67,82,19099,0.0336311388276017,0.106450363837763,6.95267564615945,0,"MYO6, VTI1A"]
["filopodium","GO:0030175",2,67,82,19099,0.0336311388276017,0.106450363837763,6.95267564615945,0,"MYO6, MYO3A"]
["cuticular plate","GO:0032437",1,67,11,19099,0.0379283903273463,0.115008667444211,25.9145183175034,0,"CIB2"]
["Schmidt-Lanterman incisure","GO:0043220",1,67,12,19099,0.0413053181274336,0.121334371999336,23.7549751243781,0,"MARVELD2"]
["stereocilium bundle","GO:0032421",1,67,12,19099,0.0413053181274336,0.121334371999336,23.7549751243781,0,"EPS8L2"]
["microtubule cytoskeleton","GO:0015630",3,67,221,19099,0.0426481257925253,0.123351502292227,3.86958870804349,0,"CLRN1, NISCH, NIN"]
["lateral plasma membrane","GO:0016328",2,67,98,19099,0.0464520215858725,0.132317879668849,5.81754492841913,0,"ATP2B1, SLC4A10"]
["collagen trimer","GO:0005581",2,67,99,19099,0.0473048343551451,0.13273595311593,5.75878184833409,0,"COL9A2, COL9A3"]
["nucleoplasm","GO:0005654",20,67,3955,19099,0.0490014952517454,0.13547472216659,1.44151555748439,0,"ANKRD11, ATP2B1, CCDC92, MYO6, TPRN, NEDD4L, PHF6, KLC2, REST, UBE2B, MED28, BAIAP2L2, NFATC3, WDTC1, NISCH, NR2F1, GGA1, EWSR1, NIN, PPM1A"]
["protein-containing complex","GO:0032991",6,67,766,19099,0.051635236428587,0.138677492122491,2.23284361482405,0,"MYO6, KLC2, IKZF5, EPS8L1, EPS8L2, GGA1"]
["basal part of cell","GO:0045178",1,67,15,19099,0.051366198986814,0.138677492122491,19.0039800995025,0,"CLRN1"]
["GABA-ergic synapse","GO:0098982",2,67,108,19099,0.0552332333218853,0.146251378373443,5.27888336097291,0,"AP3M2, SLC4A10"]
["XY body","GO:0001741",1,67,17,19099,0.0580155967846873,0.147390975615151,16.7682177348551,0,"UBE2B"]
["endosome","GO:0005768",6,67,786,19099,0.0571543230919667,0.147390975615151,2.17602825566822,0,"MYO6, NEDD4L, SPNS2, NISCH, GGA1, VTI1A"]
["somatodendritic compartment","GO:0036477",1,67,17,19099,0.0580155967846873,0.147390975615151,16.7682177348551,0,"SLC4A10"]
["Golgi apparatus","GO:0005794",9,67,1426,19099,0.060363925581815,0.151312240125083,1.79911452554897,0,"MYO6, NEDD4L, CABP2, AP3S1, ELMOD1, CHSY1, GGA1, AP3M2, VTI1A"]
["trans-Golgi network transport vesicle","GO:0030140",1,67,18,19099,0.0613230569573854,0.15169387773669,15.8366500829187,0,"CLRN1"]
["filopodium tip","GO:0032433",1,67,19,19099,0.0646190768297115,0.157771252519296,15.0031421838178,0,"MYO3A"]
["neuron projection terminus","GO:0044306",1,67,20,19099,0.0679036953754354,0.159815715559224,14.2529850746269,0,"VTI1A"]
["postsynaptic density","GO:0014069",3,67,268,19099,0.0680066874720103,0.159815715559224,3.19096680775228,0,"MPDZ, NPTN, HOMER2"]
["basolateral plasma membrane","GO:0016323",3,67,266,19099,0.066812686528962,0.159815715559224,3.21495903938952,0,"ATP2B1, MARVELD2, SLC4A10"]
["connexin complex","GO:0005922",1,67,21,19099,0.0711769514375899,0.165200825558851,13.5742714996446,0,"GJB3"]
["bicellular tight junction","GO:0005923",2,67,128,19099,0.0743459110836787,0.168608555916071,4.4540578358209,0,"MPDZ, MARVELD2"]
["pericentriolar material","GO:0000242",1,67,22,19099,0.0744388837289035,0.168608555916071,12.9572591587517,0,"NIN"]
["mitochondria-associated endoplasmic reticulum membrane contact site","GO:0044233",1,67,23,19099,0.0776895308322302,0.171830962311286,12.3939000648929,0,"ACSL4"]
["intracellular vesicle","GO:0097708",1,67,23,19099,0.0776895308322302,0.171830962311286,12.3939000648929,0,"GGA1"]
["apicolateral plasma membrane","GO:0016327",1,67,24,19099,0.0809289312009783,0.174489269677205,11.8774875621891,0,"MPDZ"]
["peroxisome","GO:0005777",2,67,135,19099,0.0814712645304269,0.174489269677205,4.22310668877833,0,"HSD17B4, ACSL4"]
["centrosome","GO:0005813",5,67,660,19099,0.0816758283595428,0.174489269677205,2.15954319312528,0,"TRIOBP, CCDC92, CCDC88C, EPS8L2, NIN"]
["clathrin-coated endocytic vesicle","GO:0045334",1,67,25,19099,0.0841571231595384,0.177770102853856,11.4023880597015,0,"MYO6"]
["cell-cell contact zone","GO:0044291",1,67,26,19099,0.0873741449037091,0.178547165672797,10.9638346727899,0,"BAIAP2L2"]
["core mediator complex","GO:0070847",1,67,26,19099,0.0873741449037091,0.178547165672797,10.9638346727899,0,"MED28"]
["membrane coat","GO:0030117",1,67,26,19099,0.0873741449037091,0.178547165672797,10.9638346727899,0,"AP3S1"]
["presynaptic membrane","GO:0042734",2,67,144,19099,0.0909280996296311,0.18381164226205,3.95916252072968,0,"ATP2B1, NPTN"]
["replication fork","GO:0005657",1,67,31,19099,0.103293028313644,0.196152417403687,9.19547424169475,0,"UBE2B"]
["gap junction","GO:0005921",1,67,31,19099,0.103293028313644,0.196152417403687,9.19547424169475,0,"GJB3"]
["perikaryon","GO:0043204",2,67,154,19099,0.101793232052343,0.196152417403687,3.70207404535763,0,"SLC17A8, SLC4A10"]
["axonal growth cone","GO:0044295",1,67,30,19099,0.100131289175501,0.196152417403687,9.50199004975124,0,"NIN"]
["Cul4-RING E3 ubiquitin ligase complex","GO:0080008",1,67,31,19099,0.103293028313644,0.196152417403687,9.19547424169475,0,"WDTC1"]
["apical junction complex","GO:0043296",1,67,31,19099,0.103293028313644,0.196152417403687,9.19547424169475,0,"CCDC88C"]
["centriole","GO:0005814",2,67,162,19099,0.110731872625061,0.208175920535115,3.51925557398194,0,"CCDC92, NIN"]
["excitatory synapse","GO:0060076",1,67,34,19099,0.112712732534703,0.209801917985388,8.38410886742757,0,"SLC17A8"]
["clathrin-coated vesicle membrane","GO:0030665",1,67,35,19099,0.115830920151812,0.213492284201378,8.14456289978678,0,"MYO6"]
["cytoplasm","GO:0005737",31,67,7344,19099,0.117321915988193,0.214140972871653,1.20327488375118,0,"OCM, ACVR2A, TRIOBP, GJB3, CCDC92, HARS2, MYO6, TPRN, NEDD4L, ACSL4, CABP2, CCDC88C, KLC2, REST, MPDZ, USH1C, MARVELD2, UBE2B, MED28, MYO3A, HOMER2, NFATC3, WDTC1, NISCH, EPS8L1, EPS8L2, EWSR1, VTI1A, CIB2, NIN, PPM1A"]
["mediator complex","GO:0016592",1,67,37,19099,0.122034946486478,0.218500666090075,7.70431625655506,0,"MED28"]
["tight junction","GO:0070160",1,67,37,19099,0.122034946486478,0.218500666090075,7.70431625655506,0,"MARVELD2"]
["mitotic spindle pole","GO:0097431",1,67,39,19099,0.12819608573103,0.225241720723679,7.30922311519326,0,"NIN"]
["vesicle membrane","GO:0012506",1,67,39,19099,0.12819608573103,0.225241720723679,7.30922311519326,0,"BAIAP2L2"]
["terminal bouton","GO:0043195",1,67,44,19099,0.143413214309463,0.249645224909065,6.47862957937585,0,"AAK1"]
["kinesin complex","GO:0005871",1,67,47,19099,0.152417582674216,0.262885371951859,6.06510003175611,0,"KLC2"]
["SNARE complex","GO:0031201",1,67,48,19099,0.155398268269473,0.265589767587826,5.93874378109453,0,"VTI1A"]
["hippocampal mossy fiber to CA3 synapse","GO:0098686",1,67,49,19099,0.15836862762205,0.267784905631046,5.81754492841913,0,"VTI1A"]
["neuronal cell body","GO:0043025",3,67,393,19099,0.1595314331419,0.267784905631046,2.17602825566822,0,"SLC17A8, VTI1A, SLC4A10"]
["peroxisomal matrix","GO:0005782",1,67,52,19099,0.167218099971198,0.275763182408642,5.48191733639495,0,"HSD17B4"]
["cytoskeleton","GO:0005856",8,67,1530,19099,0.165786577551276,0.275763182408642,1.49050824309823,0,"TRIOBP, CCDC92, MPZL2, KLC2, USH1C, MED28, MYO3A, NIN"]
["chloride channel complex","GO:0034707",1,67,56,19099,0.178874953076255,0.292421662420312,5.09035181236674,0,"SLC17A8"]
["cytoplasmic microtubule","GO:0005881",1,67,57,19099,0.181763961013234,0.29458297129731,5.00104739460592,0,"NIN"]
["axon","GO:0030424",3,67,431,19099,0.192508624805688,0.302711647211085,1.98417425632857,0,"EMB, SLC4A10, NIN"]
["ER to Golgi transport vesicle membrane","GO:0012507",1,67,61,19099,0.193220200347501,0.302711647211085,4.6731098605334,0,"VTI1A"]
["brush border","GO:0005903",1,67,61,19099,0.193220200347501,0.302711647211085,4.6731098605334,0,"USH1C"]
["cortical actin cytoskeleton","GO:0030864",1,67,60,19099,0.190371041240569,0.302711647211085,4.75099502487562,0,"MED28"]
["transcription repressor complex","GO:0017053",1,67,63,19099,0.198888920313474,0.306484565728959,4.52475716654821,0,"REST"]
["cell leading edge","GO:0031252",1,67,63,19099,0.198888920313474,0.306484565728959,4.52475716654821,0,"AAK1"]
["cell surface","GO:0009986",4,67,665,19099,0.204633294268906,0.312772840020767,1.71464482100774,0,"ACVR2A, KCNE1, NPTN, OTOA"]
["endocytic vesicle","GO:0030139",1,67,69,19099,0.215660708201158,0.32696946082111,4.13130002163098,0,"MYO6"]
["extracellular matrix","GO:0031012",2,67,249,19099,0.217436976233809,0.327025212255648,2.28963615656657,0,"OTOGL, OTOG"]
["Cajal body","GO:0015030",1,67,80,19099,0.245515434864221,0.366324617098996,3.56324626865672,0,"EWSR1"]
["neuromuscular junction","GO:0031594",1,67,81,19099,0.248173327806231,0.367374689980878,3.51925557398194,0,"CIB2"]
["anchoring junction","GO:0070161",2,67,287,19099,0.266751442969795,0.385763625217858,1.98647875604556,0,"CCDC88C, BAIAP2L2"]
["cytosol","GO:0005829",22,67,5480,19099,0.265234772638444,0.385763625217858,1.14440026146639,0,"ANKRD11, HSD17B4, HARS2, MYO6, NEDD4L, AAK1, KLC2, REST, USH1C, OTOG, BAIAP2L2, HOMER2, NFATC3, WDTC1, NISCH, UBE2G1, EPS8L1, NR2F1, EPS8L2, GGA1, VTI1A, PPM1A"]
["voltage-gated potassium channel complex","GO:0008076",1,67,87,19099,0.263928082422538,0.385763625217858,3.27654829301767,0,"KCNE1"]
["endosome membrane","GO:0010008",2,67,294,19099,0.275869718258308,0.392905356307287,1.93918164280638,0,"SPNS2, GGA1"]
["actin cytoskeleton","GO:0015629",2,67,293,19099,0.274567199466983,0.392905356307287,1.94580001018797,0,"TRIOBP, MYO6"]
["intercellular bridge","GO:0045171",1,67,94,19099,0.281897927759047,0.398472258787225,3.03255001587806,0,"NISCH"]
["actin filament","GO:0005884",1,67,97,19099,0.289466346973638,0.403108690600325,2.93875980920142,0,"MYO6"]
["endoplasmic reticulum lumen","GO:0005788",2,67,304,19099,0.288888449900643,0.403108690600325,1.87539277297722,0,"COL9A2, COL9A3"]
["Golgi cisterna membrane","GO:0032580",1,67,98,19099,0.291971649297223,0.403607868146162,2.90877246420956,0,"CHSY1"]
["cell periphery","GO:0071944",1,67,100,19099,0.296956177201634,0.407501907400782,2.85059701492537,0,"CIB2"]
["ruffle","GO:0001726",1,67,103,19099,0.304368222257849,0.41464656365562,2.76756991740328,0,"MYO6"]
["transport vesicle","GO:0030133",1,67,104,19099,0.306821756112804,0.414981943519476,2.74095866819747,0,"AP3S1"]
["lipid droplet","GO:0005811",1,67,106,19099,0.31170327786082,0.418572973127387,2.68924246691073,0,"ACSL4"]
["trans-Golgi network membrane","GO:0032588",1,67,112,19099,0.326145563580736,0.434860751440981,2.54517590618337,0,"VTI1A"]
["sarcolemma","GO:0042383",1,67,117,19099,0.337952438633511,0.447429989176761,2.43640770506442,0,"CIB2"]
["microtubule","GO:0005874",2,67,359,19099,0.359749653003024,0.472957585766213,1.58807633143475,0,"KLC2, NIN"]
["neuron projection","GO:0043005",2,67,364,19099,0.366087655241147,0.477947772120387,1.56626209611284,0,"MPDZ, SLC17A8"]
["Z disc","GO:0030018",1,67,135,19099,0.378794115059085,0.491126162973158,2.11155334438917,0,"KCNE1"]
["lysosomal membrane","GO:0005765",2,67,391,19099,0.399889477213613,0.491995710536249,1.4581058899874,0,"MYO6, KLC2"]
["monoatomic ion channel complex","GO:0034702",1,67,141,19099,0.391848416793026,0.491995710536249,2.02170001058537,0,"KCNE1"]
["blood microparticle","GO:0072562",1,67,141,19099,0.391848416793026,0.491995710536249,2.02170001058537,0,"CIB2"]
["membrane","GO:0016020",25,67,6708,19099,0.397504321038106,0.491995710536249,1.0623870806967,0,"ACVR2A, HSD17B4, ATP2B1, KCNE1, MYO6, MPZL2, ACSL4, GPR152, EMB, CLRN1, KLC2, SPNS2, AP3S1, TMTC4, MARVELD2, MED28, CYB5R2, TRAM2, CHSY1, NISCH, GGA1, AP3M2, VTI1A, SLC4A10, PPM1A"]
["collagen-containing extracellular matrix","GO:0062023",2,67,383,19099,0.389953727570108,0.491995710536249,1.4885624098827,0,"COL9A2, COL9A3"]
["side of membrane","GO:0098552",1,67,145,19099,0.400400764425777,0.491995710536249,1.9659289758106,0,"OTOA"]
["mitotic spindle","GO:0072686",1,67,137,19099,0.383175929496499,0.491995710536249,2.08072774812071,0,"NIN"]
["recycling endosome","GO:0055037",1,67,142,19099,0.393997702375623,0.491995710536249,2.00746268656716,0,"NISCH"]
["spindle pole","GO:0000922",1,67,156,19099,0.423313556053223,0.516772393103934,1.82730577879832,0,"NIN"]
["late endosome membrane","GO:0031902",1,67,159,19099,0.429411352378392,0.520834414497663,1.79282831127382,0,"VTI1A"]
["mitochondrial matrix","GO:0005759",2,67,421,19099,0.436471429052245,0.523817148066106,1.35420285744673,0,"CLPP, HARS2"]
["chromosome, centromeric region","GO:0000775",1,67,163,19099,0.437443043863716,0.523817148066106,1.74883252449409,0,"PHF6"]
["kinetochore","GO:0000776",1,67,169,19099,0.449282198709575,0.534588945300001,1.68674379581383,0,"PHF6"]
["chromosome, telomeric region","GO:0000781",1,67,172,19099,0.455109391558383,0.538116764861484,1.65732384588685,0,"TRIOBP"]
["cell cortex","GO:0005938",1,67,182,19099,0.474098128912755,0.557065301472487,1.56626209611284,0,"MYO6"]
["perinuclear region of cytoplasm","GO:0048471",3,67,740,19099,0.483760697507177,0.560352876723735,1.15564743848326,0,"MYO6, CABP2, VTI1A"]
["lamellipodium","GO:0030027",1,67,190,19099,0.488818466929215,0.560352876723735,1.50031421838178,0,"CLRN1"]
["trans-Golgi network","GO:0005802",1,67,186,19099,0.481509755932138,0.560352876723735,1.53257904028246,0,"GGA1"]
["midbody","GO:0030496",1,67,190,19099,0.488818466929215,0.560352876723735,1.50031421838178,0,"TRIOBP"]
["vesicle","GO:0031982",1,67,193,19099,0.494233309078531,0.56312643701069,1.47699327198206,0,"EPS8L2"]
["cell-cell junction","GO:0005911",1,67,203,19099,0.511877898902981,0.573692720529997,1.40423498272186,0,"GJB3"]
["extracellular exosome","GO:0070062",8,67,2209,19099,0.518327477561136,0.573692720529997,1.03235745221381,0,"ATP2B1, MYO6, NEDD4L, ACSL4, UBE2G1, EPS8L1, DNASE1, EPS8L2"]
["extracellular region","GO:0005576",9,67,2479,19099,0.510455908469438,0.573692720529997,1.03490815386561,0,"OTOGL, CCDC88C, SEMA3F, OTOG, COL9A2, CHSY1, OTOA, COL9A3, DNASE1"]
["early endosome membrane","GO:0031901",1,67,204,19099,0.513608645133586,0.573692720529997,1.39735147790459,0,"GGA1"]
["receptor complex","GO:0043235",1,67,207,19099,0.518764694096274,0.573692720529997,1.37710000721033,0,"ACVR2A"]
["lysosome","GO:0005764",2,67,499,19099,0.525690703688449,0.577952352593149,1.1425238536775,0,"KCNE1, KLC2"]
["mitochondrial outer membrane","GO:0005741",1,67,217,19099,0.535565708288317,0.5820020413769,1.31363917738496,0,"ACSL4"]
["membrane raft","GO:0045121",1,67,217,19099,0.535565708288317,0.5820020413769,1.31363917738496,0,"KCNE1"]
["nuclear envelope","GO:0005635",1,67,224,19099,0.546981264294208,0.5909912510765,1.27258795309168,0,"DNASE1"]
["endomembrane system","GO:0012505",1,67,245,19099,0.579595156757184,0.619113008354265,1.16350898568383,0,"VTI1A"]
["transcription regulator complex","GO:0005667",1,67,243,19099,0.576591474009026,0.619113008354265,1.17308519132731,0,"NFATC3"]
["postsynapse","GO:0098794",1,67,254,19099,0.592854024733666,0.624182642810096,1.1222822893407,0,"SLC4A10"]
["endoplasmic reticulum membrane","GO:0005789",4,67,1164,19099,0.589528133658629,0.624182642810096,0.979586603067139,0,"ACSL4, CYB5R2, TRAM2, VTI1A"]
["nuclear membrane","GO:0031965",1,67,255,19099,0.594301558845783,0.624182642810096,1.11788118232368,0,"MYO6"]
["chromosome","GO:0005694",2,67,674,19099,0.689695838441384,0.720348986816557,0.84587448514106,0,"TRIOBP, PHF6"]
["Golgi membrane","GO:0000139",2,67,696,19099,0.706709651256292,0.734040963735817,0.819137073254418,0,"CHSY1, VTI1A"]
["nucleolus","GO:0005730",3,67,1073,19099,0.734116203111407,0.758317836181014,0.796998233436731,0,"PHF6, EWSR1, NIN"]
["mitochondrion","GO:0005739",5,67,1757,19099,0.74990567750048,0.770394903661696,0.81121144420187,0,"CLPP, HARS2, ACSL4, KLC2, CYB5R2"]
["extracellular space","GO:0005615",5,67,1841,19099,0.78617498135853,0.798923764840019,0.77419799427631,0,"OTOGL, SEMA3F, OTOG, COL9A2, COL9A3"]
["focal adhesion","GO:0005925",1,67,429,19099,0.782329682776582,0.798923764840019,0.664474828653933,0,"TRIOBP"]
["chromatin","GO:0000785",2,67,1104,19099,0.905786031904866,0.915525666656531,0.516412502703872,0,"UBE2B, NFATC3"]
["nucleus","GO:0005634",17,67,6764,19099,0.970523635418838,0.975713601383644,0.716442182935117,0,"TRIOBP, ANKRD11, MYO6, TPRN, PHF6, REST, UBE2B, MED28, IKZF5, CYB5R2, TOX, NFATC3, WDTC1, DNASE1, NR2F1, EWSR1, PPM1A"]
["endoplasmic reticulum","GO:0005783",2,67,1666,19099,0.983773230731148,0.983773230731148,0.342208525201125,0,"ACSL4, TMTC4"]

{"sheet":"Supplementary Table S17.","index":17,"n_rows":189,"n_cols":11,"rows_kept":189}
["Supplementary Table S17.- Active biochemical pathways according to Gene Ontology - Molecular Function in Homosapiens."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["actin binding","GO:0003779",9,67,388,18329,{"v":1.12508792445829E-5,"d":"1.13E-05"},1.2241872145376E-3,6.34563009693799,0,"TRIOBP, MYO6, TPRN, MED28, MYO3A, HOMER2, EPS8L1, DNASE1, EPS8L2"]
["alpha-L-arabinofuranosidase activity","GO:0046556",2,67,2,18329,{"v":1.31633033821248e-05,"d":"1.32E-05"},1.2241872145376E-3,273.567164179104,0,"OTOGL, OTOG"]
["17-beta-hydroxysteroid dehydrogenase (NAD+) activity","GO:0044594",1,67,2,18329,0.00729765561745371,0.104037272925032,136.783582089552,0,"HSD17B4"]
["N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity","GO:0050510",1,67,4,18329,0.0145428446024239,0.104037272925032,68.3917910447761,0,"CHSY1"]
["(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity","GO:0106386",1,67,2,18329,0.00729765561745371,0.104037272925032,136.783582089552,0,"HSD17B4"]
["3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity","GO:0033989",1,67,1,18329,3.65540946041792E-3,0.104037272925032,273.567164179104,0,"HSD17B4"]
["palmitoyl-CoA ligase activity","GO:0090433",1,67,3,18329,0.0109267851571291,0.104037272925032,91.1890547263682,0,"ACSL4"]
["sodium,bicarbonate:chloride antiporter activity","GO:0140892",1,67,3,18329,0.0109267851571291,0.104037272925032,91.1890547263682,0,"SLC4A10"]
["synaptic receptor adaptor activity","GO:0030160",1,67,4,18329,0.0145428446024239,0.104037272925032,68.3917910447761,0,"HOMER2"]
["PDZ domain binding","GO:0030165",3,67,88,18329,0.00410460058689005,0.104037272925032,9.32615332428765,0,"ACVR2A, ATP2B1, CCDC88C"]
["histidine-tRNA ligase activity","GO:0004821",1,67,2,18329,0.00729765561745371,0.104037272925032,136.783582089552,0,"HARS2"]
["inhibin binding","GO:0034711",1,67,4,18329,0.0145428446024239,0.104037272925032,68.3917910447761,0,"ACVR2A"]
["G protein-coupled glutamate receptor binding","GO:0035256",1,67,3,18329,0.0109267851571291,0.104037272925032,91.1890547263682,0,"HOMER2"]
["ADP binding","GO:0043531",2,67,39,18329,0.00893965123098451,0.104037272925032,14.0290853425182,0,"MYO6, MYO3A"]
["ubiquitin-like protein transferase activity","GO:0019787",2,67,35,18329,0.00724594338792877,0.104037272925032,15.6324093816631,0,"UBE2B, UBE2G1"]
["minus-end directed microfilament motor activity","GO:0060001",1,67,1,18329,3.65540946041792E-3,0.104037272925032,273.567164179104,0,"MYO6"]
["activin receptor activity","GO:0017002",1,67,4,18329,0.0145428446024239,0.104037272925032,68.3917910447761,0,"ACVR2A"]
["phosphatidylinositol binding","GO:0035091",3,67,112,18329,0.00801184765922157,0.104037272925032,7.32769189765458,0,"NISCH, GGA1, ZCCHC14"]
["plus-end directed microfilament motor activity","GO:0060002",1,67,3,18329,0.0109267851571291,0.104037272925032,91.1890547263682,0,"MYO3A"]
["L-glutamate uniporter activity","GO:0140788",1,67,3,18329,0.0109267851571291,0.104037272925032,91.1890547263682,0,"SLC17A8"]
["extracellular matrix structural constituent conferring tensile strength","GO:0030020",2,67,45,18329,0.0117769345635919,0.104037272925032,12.1585406301824,0,"COL9A2, COL9A3"]
["ubiquitin conjugating enzyme activity","GO:0061631",2,67,34,18329,0.00684794725290218,0.104037272925032,16.0921861281826,0,"UBE2B, UBE2G1"]
["sphingolipid transporter activity","GO:0046624",1,67,4,18329,0.0145428446024239,0.104037272925032,68.3917910447761,0,"SPNS2"]
["potassium channel regulator activity","GO:0015459",2,67,47,18329,0.0127994063979944,0.104037272925032,11.6411559225151,0,"KCNE1, NEDD4L"]
["microfilament motor activity","GO:0000146",2,67,38,18329,0.00850112082908388,0.104037272925032,14.3982717989002,0,"MYO6, MYO3A"]
["calmodulin binding","GO:0005516",4,67,207,18329,0.00695600638587858,0.104037272925032,5.28632201312279,0,"ATP2B1, MYO6, MYO3A, EWSR1"]
["cytochrome-b5 reductase activity, acting on NAD(P)H","GO:0004128",1,67,6,18329,0.0217359384899429,0.112100717172362,45.5945273631841,0,"CYB5R2"]
["ATP-dependent peptidase activity","GO:0004176",1,67,7,18329,0.0253130651679527,0.112100717172362,39.0810234541578,0,"CLPP"]
["secondary active transmembrane transporter activity","GO:0015291",1,67,7,18329,0.0253130651679527,0.112100717172362,39.0810234541578,0,"SLC4A10"]
["glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity","GO:0047238",1,67,6,18329,0.0217359384899429,0.112100717172362,45.5945273631841,0,"CHSY1"]
["retinoic acid-responsive element binding","GO:0044323",1,67,6,18329,0.0217359384899429,0.112100717172362,45.5945273631841,0,"NR2F1"]
["calmodulin-dependent protein phosphatase activity","GO:0033192",1,67,5,18329,0.0181458803138366,0.112100717172362,54.7134328358209,0,"PPM1A"]
["DNA-binding transcription repressor activity, RNA polymerase II-specific","GO:0001227",4,67,271,18329,0.0173084017942796,0.112100717172362,4.0378917222008,0,"REST, IKZF5, NFATC3, NR2F1"]
["voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization","GO:0086008",1,67,7,18329,0.0253130651679527,0.112100717172362,39.0810234541578,0,"KCNE1"]
["deoxyribonuclease I activity","GO:0004530",1,67,5,18329,0.0181458803138366,0.112100717172362,54.7134328358209,0,"DNASE1"]
["type 1 fibroblast growth factor receptor binding","GO:0005105",1,67,6,18329,0.0217359384899429,0.112100717172362,45.5945273631841,0,"NPTN"]
["sodium:bicarbonate symporter activity","GO:0008510",1,67,6,18329,0.0217359384899429,0.112100717172362,45.5945273631841,0,"SLC4A10"]
["3-hydroxyacyl-CoA dehydrogenase activity","GO:0003857",1,67,6,18329,0.0217359384899429,0.112100717172362,45.5945273631841,0,"HSD17B4"]
["potassium channel inhibitor activity","GO:0019870",1,67,6,18329,0.0217359384899429,0.112100717172362,45.5945273631841,0,"NEDD4L"]
["DNA nuclease activity","GO:0004536",1,67,7,18329,0.0253130651679527,0.112100717172362,39.0810234541578,0,"DNASE1"]
["telethonin binding","GO:0031433",1,67,7,18329,0.0253130651679527,0.112100717172362,39.0810234541578,0,"KCNE1"]
["enoyl-CoA hydratase activity","GO:0004300",1,67,7,18329,0.0253130651679527,0.112100717172362,39.0810234541578,0,"HSD17B4"]
["BMP receptor activity","GO:0098821",1,67,8,18329,0.0288773062242647,0.116764759950288,34.1958955223881,0,"ACVR2A"]
["sodium channel inhibitor activity","GO:0019871",1,67,8,18329,0.0288773062242647,0.116764759950288,34.1958955223881,0,"NEDD4L"]
["dolichyl-phosphate-mannose-protein mannosyltransferase activity","GO:0004169",1,67,8,18329,0.0288773062242647,0.116764759950288,34.1958955223881,0,"TMTC4"]
["3-hydroxyacyl-CoA dehydratase activity","GO:0018812",1,67,8,18329,0.0288773062242647,0.116764759950288,34.1958955223881,0,"HSD17B4"]
["P-type calcium transporter activity","GO:0005388",1,67,9,18329,0.0324287073750192,0.128334884505395,30.3963515754561,0,"ATP2B1"]
["ATPase binding","GO:0051117",2,67,84,18329,0.0378686530373406,0.131173749944936,6.5135039090263,0,"CLPP, TMTC4"]
["activin binding","GO:0048185",1,67,11,18329,0.0394931720264323,0.131173749944936,24.8697421981004,0,"ACVR2A"]
["myosin II binding","GO:0045159",1,67,10,18329,0.0359673141766499,0.131173749944936,27.3567164179104,0,"TRIOBP"]
["T cell receptor binding","GO:0042608",1,67,11,18329,0.0394931720264323,0.131173749944936,24.8697421981004,0,"EPS8L1"]
["AP-2 adaptor complex binding","GO:0035612",1,67,10,18329,0.0359673141766499,0.131173749944936,27.3567164179104,0,"AAK1"]
["cytoskeletal motor activity","GO:0003774",2,67,81,18329,0.035441882143984,0.131173749944936,6.75474479454579,0,"MYO6, MYO3A"]
["acetylgalactosaminyltransferase activity","GO:0008376",1,67,11,18329,0.0394931720264323,0.131173749944936,24.8697421981004,0,"CHSY1"]
["arachidonate-CoA ligase activity","GO:0047676",1,67,11,18329,0.0394931720264323,0.131173749944936,24.8697421981004,0,"ACSL4"]
["very long-chain fatty acid-CoA ligase activity","GO:0031957",1,67,10,18329,0.0359673141766499,0.131173749944936,27.3567164179104,0,"ACSL4"]
["voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization","GO:1902282",1,67,12,18329,0.0430063261630318,0.133319611105399,22.797263681592,0,"KCNE1"]
["sodium:phosphate symporter activity","GO:0005436",1,67,12,18329,0.0430063261630318,0.133319611105399,22.797263681592,0,"SLC17A8"]
["calcium ion transmembrane transporter activity","GO:0015085",1,67,12,18329,0.0430063261630318,0.133319611105399,22.797263681592,0,"ATP2B1"]
["transmembrane receptor protein serine/threonine kinase activity","GO:0004675",1,67,12,18329,0.0430063261630318,0.133319611105399,22.797263681592,0,"ACVR2A"]
["L-glutamate transmembrane transporter activity","GO:0005313",1,67,13,18329,0.0465068216670487,0.14180768573887,21.0436280137773,0,"SLC17A8"]
["protein serine/threonine phosphatase inhibitor activity","GO:0004865",1,67,14,18329,0.0499947034615621,0.14760341021985,19.5405117270789,0,"TPRN"]
["microtubule minus-end binding","GO:0051011",1,67,14,18329,0.0499947034615621,0.14760341021985,19.5405117270789,0,"NIN"]
["monoatomic anion transmembrane transporter activity","GO:0008509",1,67,15,18329,0.0534700163126718,0.150688227790257,18.2378109452736,0,"SLC4A10"]
["guanyl-nucleotide exchange factor activity","GO:0005085",3,67,231,18329,0.0525659974833257,0.150688227790257,3.55282031401434,0,"CCDC88C, EPS8L1, EPS8L2"]
["long-chain fatty acid-CoA ligase activity","GO:0004467",1,67,15,18329,0.0534700163126718,0.150688227790257,18.2378109452736,0,"ACSL4"]
["protein binding","GO:0005515",56,67,13681,18329,0.0565622026502084,0.155727966152752,1.11978372882317,0,"OCM, ACVR2A, TRIOBP, OTOGL, GJB3, KLHL18, CLPP, ATP2B1, CCDC92, KCNE1, HARS2, MYO6, TPRN, MPZL2, NEDD4L, GPR152, PHF6, AAK1, EMB, CLRN1, CABP2, CCDC88C, KLC2, REST, MPDZ, GRXCR1, AP3S1, USH1C, SLC17A8, MARVELD2, UBE2B, MED28, NPTN, IKZF5, CYB5R2, COL9A2, TRAM2, MYO3A, TOX, HOMER2, NFATC3, WDTC1, NISCH, UBE2G1, EPS8L1, DNASE1, NR2F1, EPS8L2, GGA1, EWSR1, AP3M2, VTI1A, CIB2, ZCCHC14, NIN, PPM1A"]
["dynein heavy chain binding","GO:0045504",1,67,16,18329,0.0569328048300384,0.155727966152752,17.097947761194,0,"NISCH"]
["ubiquitin-protein transferase activity","GO:0004842",3,67,245,18329,0.0605757544789908,0.16095843332989,3.34980201035638,0,"NEDD4L, UBE2B, UBE2G1"]
["transforming growth factor beta receptor activity","GO:0005024",1,67,17,18329,0.060383113467421,0.16095843332989,16.0921861281826,0,"ACVR2A"]
["ligase activity","GO:0016874",2,67,116,18329,0.0673022639209065,0.171482480675186,4.71667524446732,0,"HARS2, ACSL4"]
["mannosyltransferase activity","GO:0000030",1,67,19,18329,0.0672464681409817,0.171482480675186,14.3982717989002,0,"TMTC4"]
["neurotransmitter transmembrane transporter activity","GO:0005326",1,67,19,18329,0.0672464681409817,0.171482480675186,14.3982717989002,0,"SLC17A8"]
["solute:inorganic anion antiporter activity","GO:0005452",1,67,20,18329,0.0706596023099907,0.172930079337609,13.6783582089552,0,"SLC4A10"]
["estradiol 17-beta-dehydrogenase [NAD(P)+] activity","GO:0004303",1,67,20,18329,0.0706596023099907,0.172930079337609,13.6783582089552,0,"HSD17B4"]
["RNA polymerase II core promoter sequence-specific DNA binding","GO:0000979",1,67,20,18329,0.0706596023099907,0.172930079337609,13.6783582089552,0,"REST"]
["monoatomic ion transmembrane transporter activity","GO:0015075",1,67,21,18329,0.0740604328657409,0.176605647602921,13.0270078180526,0,"SLC4A10"]
["bicarbonate transmembrane transporter activity","GO:0015106",1,67,21,18329,0.0740604328657409,0.176605647602921,13.0270078180526,0,"SLC4A10"]
["symporter activity","GO:0015293",2,67,124,18329,0.0755498861609758,0.177876947163817,4.41237361579201,0,"SLC17A8, SLC4A10"]
["gap junction channel activity","GO:0005243",1,67,22,18329,0.0774490034904949,0.180068933115401,12.4348710990502,0,"GJB3"]
["histone deacetylase binding","GO:0042826",2,67,127,18329,0.0787224212927892,0.180770004450109,4.30814431778117,0,"PHF6, WDTC1"]
["transferase activity","GO:0016740",5,67,637,18329,0.0831998505960344,0.188665713708737,2.14730898099768,0,"NEDD4L, TMTC4, UBE2B, CHSY1, UBE2G1"]
["semaphorin receptor binding","GO:0030215",1,67,24,18329,0.0841895389130388,0.188665713708737,11.398631840796,0,"SEMA3F"]
["protein phosphatase 1 binding","GO:0008157",1,67,26,18329,0.0908815549909668,0.194298496877239,10.5218140068886,0,"TPRN"]
["R-SMAD binding","GO:0070412",1,67,26,18329,0.0908815549909668,0.194298496877239,10.5218140068886,0,"PPM1A"]
["spectrin binding","GO:0030507",1,67,26,18329,0.0908815549909668,0.194298496877239,10.5218140068886,0,"USH1C"]
["cell-cell adhesion mediator activity","GO:0098632",1,67,26,18329,0.0908815549909668,0.194298496877239,10.5218140068886,0,"EMB"]
["Notch binding","GO:0005112",1,67,27,18329,0.0942094758681785,0.197170908737023,10.1321171918187,0,"AAK1"]
["dynein light intermediate chain binding","GO:0051959",1,67,28,18329,0.0975253957193878,0.197170908737023,9.77025586353945,0,"CCDC88C"]
["chemorepellent activity","GO:0045499",1,67,28,18329,0.0975253957193878,0.197170908737023,9.77025586353945,0,"SEMA3F"]
["transmembrane transporter binding","GO:0044325",2,67,143,18329,0.0963127552228833,0.197170908737023,3.82611418432314,0,"KCNE1, NEDD4L"]
["ATP binding","GO:0005524",9,67,1499,18329,0.0944141663987786,0.197170908737023,1.64249798373045,0,"ACVR2A, ATP2B1, HARS2, MYO6, ACSL4, AAK1, UBE2B, MYO3A, UBE2G1"]
["ubiquitin protein ligase binding","GO:0031625",3,67,306,18329,0.101484426749244,0.202968853498487,2.68203102136377,0,"TRIOBP, UBE2B, UBE2G1"]
["delayed rectifier potassium channel activity","GO:0005251",1,67,30,18329,0.104121402691794,0.203858746322881,9.11890547263682,0,"KCNE1"]
["G-protein alpha-subunit binding","GO:0001965",1,67,30,18329,0.104121402691794,0.203858746322881,9.11890547263682,0,"CCDC88C"]
["identical protein binding","GO:0042802",10,67,1779,18329,0.111382455680485,0.213578729449177,1.53775808982071,0,"ACVR2A, CLPP, CCDC92, HARS2, MYO6, GPR152, CCDC88C, REST, NISCH, EWSR1"]
["molecular function inhibitor activity","GO:0140678",1,67,32,18329,0.110669915116569,0.213578729449177,8.54897388059701,0,"ATP2B1"]
["cadherin binding","GO:0045296",3,67,321,18329,0.112895609568238,0.214271258976453,2.55670246896359,0,"KLC2, EPS8L1, EPS8L2"]
["integrin binding","GO:0005178",2,67,159,18329,0.114900808349255,0.215874245989509,3.44109640476861,0,"NISCH, CIB2"]
["SNAP receptor activity","GO:0005484",1,67,37,18329,0.126835612257744,0.228172590250771,7.3937071399758,0,"VTI1A"]
["sodium channel regulator activity","GO:0017080",1,67,36,18329,0.12362580132947,0.228172590250771,7.59908789386401,0,"NEDD4L"]
["aminoacyl-tRNA ligase activity","GO:0004812",1,67,38,18329,0.130033841755816,0.228172590250771,7.19913589945012,0,"HARS2"]
["hexosyltransferase activity","GO:0016758",1,67,37,18329,0.126835612257744,0.228172590250771,7.3937071399758,0,"CHSY1"]
["phosphoprotein binding","GO:0051219",1,67,38,18329,0.130033841755816,0.228172590250771,7.19913589945012,0,"PHF6"]
["frizzled binding","GO:0005109",1,67,38,18329,0.130033841755816,0.228172590250771,7.19913589945012,0,"CCDC88C"]
["ribonucleoprotein complex binding","GO:0043021",1,67,37,18329,0.126835612257744,0.228172590250771,7.3937071399758,0,"PHF6"]
["histone binding","GO:0042393",2,67,173,18329,0.131852431483731,0.229201422953028,3.16262617548098,0,"PHF6, WDTC1"]
["calcium channel regulator activity","GO:0005246",1,67,40,18329,0.136395720943212,0.232748661426031,6.83917910447761,0,"CABP2"]
["FAD binding","GO:0071949",1,67,40,18329,0.136395720943212,0.232748661426031,6.83917910447761,0,"CYB5R2"]
["kinesin binding","GO:0019894",1,67,43,18329,0.14585270323945,0.246623661841251,6.36202707393266,0,"KLC2"]
["alpha-tubulin binding","GO:0043014",1,67,45,18329,0.152100607256606,0.254871287835394,6.07927031509121,0,"NISCH"]
["protein phosphatase inhibitor activity","GO:0004864",1,67,46,18329,0.155207654911048,0.255474547021724,5.94711226476314,0,"TPRN"]
["enzyme inhibitor activity","GO:0004857",1,67,46,18329,0.155207654911048,0.255474547021724,5.94711226476314,0,"WDTC1"]
["transmembrane transporter activity","GO:0022857",2,67,198,18329,0.163390299874397,0.26599885919803,2.76330468867782,0,"SPNS2, SLC17A8"]
["growth factor binding","GO:0019838",1,67,49,18329,0.164461660256846,0.26599885919803,5.58300335059397,0,"ACVR2A"]
["phosphatase binding","GO:0019902",1,67,52,18329,0.173615792228059,0.276004592772812,5.26090700344432,0,"TPRN"]
["nuclear receptor activity","GO:0004879",1,67,52,18329,0.173615792228059,0.276004592772812,5.26090700344432,0,"NR2F1"]
["actin filament binding","GO:0051015",2,67,215,18329,0.185544958296635,0.292469171552323,2.54481082957307,0,"TRIOBP, MYO6"]
["protein serine/threonine kinase activity","GO:0004674",3,67,411,18329,0.190068464787344,0.294606120420383,1.99684061444602,0,"ACVR2A, AAK1, MYO3A"]
["transcription factor binding","GO:0008134",1,67,57,18329,0.188653616664719,0.294606120420383,4.79942393296675,0,"NFATC3"]
["coreceptor activity","GO:0015026",1,67,61,18329,0.200489509638922,0.308190485891235,4.48470760949352,0,"ACVR2A"]
["magnesium ion binding","GO:0000287",2,67,231,18329,0.206770770777473,0.315240683316475,2.36854687600956,0,"CIB2, PPM1A"]
["voltage-gated potassium channel activity","GO:0005249",1,67,64,18329,0.209254654738752,0.316433868141528,4.27448694029851,0,"KCNE1"]
["SNARE binding","GO:0000149",1,67,67,18329,0.217925125056608,0.326887687584911,4.0830920026732,0,"VTI1A"]
["cell adhesion molecule binding","GO:0050839",1,67,69,18329,0.223653339358323,0.327555284414552,3.96474150984209,0,"NPTN"]
["manganese ion binding","GO:0030145",1,67,69,18329,0.223653339358323,0.327555284414552,3.96474150984209,0,"PPM1A"]
["tubulin binding","GO:0015631",1,67,69,18329,0.223653339358323,0.327555284414552,3.96474150984209,0,"PHF6"]
["scaffold protein binding","GO:0097110",1,67,70,18329,0.226501927872179,0.329105533201955,3.90810234541578,0,"PHF6"]
["histone H2AS1 kinase activity","GO:0044024",2,67,247,18329,0.22825061173684,0.329105533201955,2.21511873829234,0,"AAK1, MYO3A"]
["DNA-binding transcription factor activity","GO:0003700",4,67,677,18329,0.234658478024907,0.335742130097174,1.61634956678939,0,"REST, IKZF5, NFATC3, NR2F1"]
["transcription cis-regulatory region binding","GO:0000976",2,67,259,18329,0.244469100487539,0.346855878322095,2.1124877542788,0,"REST, NFATC3"]
["chloride channel activity","GO:0005254",1,67,77,18329,0.24615578461568,0.346855878322095,3.55282031401434,0,"SLC17A8"]
["chromatin DNA binding","GO:0031490",1,67,84,18329,0.265317521887084,0.371045556924794,3.25675195451315,0,"TOX"]
["myosin phosphatase activity","GO:0017018",1,67,85,18329,0.268015451513479,0.371917189632851,3.21843722563652,0,"PPM1A"]
["calcium ion binding","GO:0005509",4,67,721,18329,0.269939895701263,0.371917189632851,1.51770964870516,0,"OCM, CABP2, CIB2, NIN"]
["endonuclease activity","GO:0004519",1,67,89,18329,0.278709916113165,0.378394484649991,3.07378836156297,0,"DNASE1"]
["potassium channel activity","GO:0005267",1,67,89,18329,0.278709916113165,0.378394484649991,3.07378836156297,0,"KCNE1"]
["small GTPase binding","GO:0031267",2,67,288,18329,0.283812464179448,0.382529843024473,1.899771973466,0,"TRIOBP, GGA1"]
["protein phosphatase binding","GO:0019903",1,67,92,18329,0.286629614861793,0.383547542189162,2.97355613238157,0,"TPRN"]
["protein homodimerization activity","GO:0042803",4,67,746,18329,0.290422544276048,0.385847094538178,1.46684806530351,0,"HSD17B4, COL9A2, COL9A3, CIB2"]
["protein serine/threonine phosphatase activity","GO:0004722",1,67,95,18329,0.29446363986927,0.388441397274356,2.87965435978005,0,"PPM1A"]
["endopeptidase activity","GO:0004175",1,67,98,18329,0.302212904044557,0.395856339100617,2.79150167529698,0,"CLPP"]
["ubiquitin binding","GO:0043130",1,67,102,18329,0.31241496603756,0.40635792785305,2.68203102136377,0,"GGA1"]
["kinase binding","GO:0019900",1,67,104,18329,0.317460753735632,0.410053473575191,2.63045350172216,0,"NIN"]
["antiporter activity","GO:0015297",1,67,116,18329,0.346978439884744,0.445089584955603,2.35833762223366,0,"SLC4A10"]
["phospholipid binding","GO:0005543",1,67,125,18329,0.368288009736046,0.469188834321264,2.18853731343284,0,"BAIAP2L2"]
["transcription coregulator activity","GO:0003712",1,67,127,18329,0.372929624040759,0.471870136541369,2.15407215889059,0,"EWSR1"]
["nucleotide binding","GO:0000166",1,67,129,18329,0.377537638617215,0.474472978262176,2.12067569131089,0,"ACSL4"]
["kinase activity","GO:0016301",2,67,363,18329,0.384029078168691,0.479392003619977,1.50725710291518,0,"EPS8L1, CIB2"]
["protein serine kinase activity","GO:0106310",2,67,365,18329,0.386634907598573,0.479427285422231,1.4989981598855,0,"AAK1, MYO3A"]
["protein-containing complex binding","GO:0044877",2,67,369,18329,0.391832725976805,0.482654881004542,1.48274885733932,0,"KCNE1, CIB2"]
["protein kinase activity","GO:0004672",2,67,375,18329,0.399593794610509,0.485780691487285,1.45902487562189,0,"AAK1, MYO3A"]
["isomerase activity","GO:0016853",1,67,138,18329,0.397864291529915,0.485780691487285,1.98237075492105,0,"HSD17B4"]
["serine-type peptidase activity","GO:0008236",1,67,140,18329,0.402291744961839,0.485884834824039,1.95405117270789,0,"CLPP"]
["lyase activity","GO:0016829",1,67,155,18329,0.43449099259267,0.518046952706645,1.7649494463168,0,"HSD17B4"]
["phosphoprotein phosphatase activity","GO:0004721",1,67,155,18329,0.43449099259267,0.518046952706645,1.7649494463168,0,"PPM1A"]
["ATP hydrolysis activity","GO:0016887",2,67,427,18329,0.464825721703401,0.55068524991613,1.28134503128386,0,"ATP2B1, MYO3A"]
["serine-type endopeptidase activity","GO:0004252",1,67,180,18329,0.48440057661346,0.561722631115119,1.5198175787728,0,"CLPP"]
["structural molecule activity","GO:0005198",1,67,181,18329,0.486303996160921,0.561722631115119,1.51142079656964,0,"OTOG"]
["peptidase activity","GO:0008233",1,67,182,18329,0.488200493419971,0.561722631115119,1.50311628669838,0,"CLPP"]
["oxidoreductase activity","GO:0016491",2,67,440,18329,0.480500916108046,0.561722631115119,1.24348710990502,0,"HSD17B4, CYB5R2"]
["molecular_function","GO:0003674",3,67,716,18329,0.489242291616394,0.561722631115119,1.14623113482865,0,"TPRN, GRXCR1, GGA1"]
["RNA polymerase II-specific DNA-binding transcription factor binding","GO:0061629",1,67,187,18329,0.497580010147846,0.567790686426376,1.46292601165297,0,"REST"]
["sequence-specific DNA binding","GO:0043565",2,67,462,18329,0.506395824463345,0.574326971647453,1.18427343800478,0,"REST, NR2F1"]
["protein dimerization activity","GO:0046983",1,67,194,18329,0.510427460357386,0.575390955311962,1.41014002154178,0,"CCDC88C"]
["chromatin binding","GO:0003682",2,67,487,18329,0.534815440316285,0.599251035535114,1.12347911367189,0,"REST, IKZF5"]
["protein domain specific binding","GO:0019904",1,67,222,18329,0.558659214727165,0.622219245145225,1.2322845233293,0,"IKZF5"]
["glycosyltransferase activity","GO:0016757",1,67,239,18329,0.58562601808885,0.648371662884084,1.14463248610504,0,"CHSY1"]
["zinc ion binding","GO:0008270",3,67,846,18329,0.603240743180206,0.66392176468354,0.970096326876257,0,"IKZF5, NR2F1, ZCCHC14"]
["sequence-specific double-stranded DNA binding","GO:1990837",2,67,571,18329,0.622053337226023,0.680599533670825,0.958203727422432,0,"NFATC3, NR2F1"]
["RNA polymerase II cis-regulatory region sequence-specific DNA binding","GO:0000978",4,67,1170,18329,0.62672362265774,0.681699379031226,0.935272356167879,0,"REST, IKZF5, NFATC3, NR2F1"]
["microtubule binding","GO:0008017",1,67,271,18329,0.632056896099341,0.68350338764231,1.0094729305502,0,"CCDC88C"]
["GTPase activator activity","GO:0005096",1,67,276,18329,0.638833012922757,0.686837805801346,0.991185377460524,0,"ELMOD1"]
["nucleic acid binding","GO:0003676",1,67,289,18329,0.655880927932444,0.701114095376061,0.946599184010742,0,"ZCCHC14"]
["ubiquitin protein ligase activity","GO:0061630",1,67,351,18329,0.72688270679114,0.763842844424587,0.779393630139899,0,"NEDD4L"]
["lipid binding","GO:0008289",1,67,344,18329,0.719651997833733,0.763842844424587,0.795253384241583,0,"BAIAP2L2"]
["metal ion binding","GO:0046872",13,67,3986,18329,0.724467882229569,0.763842844424587,0.892216039721114,0,"OCM, ACVR2A, ATP2B1, PHF6, CABP2, REST, IKZF5, CHSY1, NR2F1, EWSR1, CIB2, ZCCHC14, PPM1A"]
["DNA binding","GO:0003677",7,67,2282,18329,0.744403064246463,0.777859381740686,0.839163080304001,0,"PHF6, REST, IKZF5, TOX, NFATC3, DNASE1, NR2F1"]
["GTP binding","GO:0005525",1,67,383,18329,0.757665651334736,0.783210216935614,0.7142745801021,0,"NIN"]
["RNA polymerase II transcription regulatory region sequence-specific DNA binding","GO:0000977",1,67,384,18329,0.758570387842067,0.783210216935614,0.712414490049751,0,"IKZF5"]
["enzyme binding","GO:0019899",1,67,388,18329,0.762156178845947,0.783210216935614,0.705070010770888,0,"PHF6"]
["signaling receptor binding","GO:0005102",1,67,419,18329,0.788223404833732,0.805546996148759,0.652904926441777,0,"SEMA3F"]
["DNA-binding transcription activator activity, RNA polymerase II-specific","GO:0001228",1,67,482,18329,0.832831684597604,0.84648466303363,0.567566730662042,0,"NFATC3"]
["RNA binding","GO:0003723",3,67,1530,18329,0.926359194873154,0.936428316556558,0.536406204272754,0,"HARS2, PHF6, EWSR1"]
["G protein-coupled receptor activity","GO:0004930",1,67,738,18329,0.936618218510605,0.941681019691744,0.37068721433483,0,"GPR152"]
["DNA-binding transcription factor activity, RNA polymerase II-specific","GO:0000981",1,67,1236,18329,0.990780015309814,0.990780015309814,0.221332657102835,0,"NFATC3"]

{"sheet":"Supplementary Table S18.","index":18,"n_rows":78,"n_cols":11,"rows_kept":78}
["Supplementary Table S18.- Active biochemical pathways according to KEGG Reactome in Homosapiens."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["Tight junction","hsa04530",3,31,170,8377,0.0243432974006874,0.455635497708366,4.76869070208729,0,"NEDD4L, MPDZ, MARVELD2"]
["Fatty acid metabolism","hsa01212",2,31,57,8377,0.0186419388037459,0.455635497708366,9.48160724391624,0,"HSD17B4, ACSL4"]
["Peroxisome","hsa04146",2,31,83,8377,0.0374619415389785,0.455635497708366,6.51146521570152,0,"HSD17B4, ACSL4"]
["Motor proteins","hsa04814",3,31,194,8377,0.034168639238285,0.455635497708366,4.17874958430329,0,"MYO6, KLC2, MYO3A"]
["ECM-receptor interaction","hsa04512",2,31,89,8377,0.0425259797861141,0.455635497708366,6.07249003262051,0,"COL9A2, COL9A3"]
["Lysosome","hsa04142",3,31,132,8377,0.0124579786446319,0.455635497708366,6.14149560117302,0,"AP3S1, GGA1, AP3M2"]
["Ubiquitin mediated proteolysis","hsa04120",3,31,142,8377,0.0151534071151298,0.455635497708366,5.70899591094957,0,"NEDD4L, UBE2B, UBE2G1"]
["Primary bile acid biosynthesis","hsa00120",1,31,17,8377,0.0611386077568564,0.464601272658125,15.8956356736243,0,"HSD17B4"]
["Protein digestion and absorption","hsa04974",2,31,103,8377,0.0552642834160235,0.464601272658125,5.2471030378954,0,"COL9A2, COL9A3"]
["Glutamatergic synapse","hsa04724",2,31,116,8377,0.0681415199898584,0.464601272658125,4.65906562847608,0,"SLC17A8, HOMER2"]
["Fatty acid biosynthesis","hsa00061",1,31,18,8377,0.0646200315797676,0.464601272658125,15.0125448028674,0,"ACSL4"]
["Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate","hsa00532",1,31,21,8377,0.0749895084617822,0.468684427886139,12.8678955453149,0,"CHSY1"]
["Fatty acid degradation","hsa00071",1,31,43,8377,0.147705445292828,0.471486648168027,6.28432108027007,0,"ACSL4"]
["Signaling pathways regulating pluripotency of stem cells","hsa04550",2,31,144,8377,0.0987693115356682,0.471486648168027,3.75313620071685,0,"ACVR2A, REST"]
["Biosynthesis of unsaturated fatty acids","hsa01040",1,31,27,8377,0.0953957590623877,0.471486648168027,10.0083632019116,0,"HSD17B4"]
["Adrenergic signaling in cardiomyocytes","hsa04261",2,31,153,8377,0.109323087953365,0.471486648168027,3.53236348302762,0,"ATP2B1, KCNE1"]
["Aminoacyl-tRNA biosynthesis","hsa00970",1,31,44,8377,0.150875727413769,0.471486648168027,6.14149560117302,0,"HARS2"]
["SNARE interactions in vesicular transport","hsa04130",1,31,33,8377,0.115366047225372,0.471486648168027,8.18866080156403,0,"VTI1A"]
["Wnt signaling pathway","hsa04310",2,31,174,8377,0.135032500806981,0.471486648168027,3.10604375231739,0,"CCDC88C, NFATC3"]
["Nicotine addiction","hsa05033",1,31,41,8377,0.141330481063289,0.471486648168027,6.59087332808812,0,"SLC17A8"]
["Ferroptosis","hsa04216",1,31,42,8377,0.144523709840525,0.471486648168027,6.43394777265745,0,"ACSL4"]
["Aldosterone-regulated sodium reabsorption","hsa04960",1,31,38,8377,0.131681432821331,0.471486648168027,7.11120543293718,0,"NEDD4L"]
["Axon guidance","hsa04360",2,31,184,8377,0.147729214613665,0.471486648168027,2.93723702664797,0,"SEMA3F, NFATC3"]
["cGMP-PKG signaling pathway","hsa04022",2,31,166,8377,0.125074505026687,0.471486648168027,3.25573260785076,0,"ATP2B1, NFATC3"]
["Amino sugar and nucleotide sugar metabolism","hsa00520",1,31,49,8377,0.166556728440526,0.496942775983035,5.51481237656353,0,"CYB5R2"]
["Endocrine and other factor-regulated calcium reabsorption","hsa04961",1,31,53,8377,0.178899399353893,0.496942775983035,5.09860012172855,0,"ATP2B1"]
["Focal adhesion","hsa04510",2,31,203,8377,0.172498726459217,0.496942775983035,2.66232321627205,0,"COL9A2, COL9A3"]
["Mineral absorption","hsa04978",1,31,60,8377,0.200074707193289,0.535914394267738,4.50376344086022,0,"ATP2B1"]
["Cytoskeleton in muscle cells","hsa04820",2,31,232,8377,0.211515852986276,0.540273113124627,2.32953281423804,0,"COL9A2, COL9A3"]
["PPAR signaling pathway","hsa03320",1,31,76,8377,0.246509820710649,0.540273113124627,3.55560271646859,0,"ACSL4"]
["Salmonella infection","hsa05132",2,31,248,8377,0.233454785373527,0.540273113124627,2.17924037460978,0,"MYO6, KLC2"]
["Adipocytokine signaling pathway","hsa04920",1,31,70,8377,0.229410821516076,0.540273113124627,3.86036866359447,0,"ACSL4"]
["Calcium signaling pathway","hsa04020",2,31,252,8377,0.238968973634108,0.540273113124627,2.14464925755248,0,"ATP2B1, NFATC3"]
["Parkinson disease","hsa05012",2,31,254,8377,0.241729473081208,0.540273113124627,2.12776225552451,0,"KLC2, UBE2G1"]
["Synaptic vesicle cycle","hsa04721",1,31,78,8377,0.252127452791492,0.540273113124627,3.46443341604632,0,"SLC17A8"]
["Th1 and Th2 cell differentiation","hsa04658",1,31,92,8377,0.290331441970677,0.54078591971311,2.93723702664797,0,"NFATC3"]
["PD-L1 expression and PD-1 checkpoint pathway in cancer","hsa05235",1,31,90,8377,0.284991721624208,0.54078591971311,3.00250896057348,0,"NFATC3"]
["Salivary secretion","hsa04970",1,31,93,8377,0.292986810141939,0.54078591971311,2.90565383281304,0,"ATP2B1"]
["TGF-beta signaling pathway","hsa04350",1,31,108,8377,0.331682030757374,0.54078591971311,2.5020908004779,0,"ACVR2A"]
["Pancreatic secretion","hsa04972",1,31,102,8377,0.316456408609565,0.54078591971311,2.64927261227072,0,"ATP2B1"]
["B cell receptor signaling pathway","hsa04662",1,31,83,8377,0.265994784984601,0.54078591971311,3.25573260785076,0,"NFATC3"]
["C-type lectin receptor signaling pathway","hsa04625",1,31,105,8377,0.324110708528053,0.54078591971311,2.57357910906298,0,"NFATC3"]
["Th17 cell differentiation","hsa04659",1,31,108,8377,0.331682030757374,0.54078591971311,2.5020908004779,0,"NFATC3"]
["Aldosterone synthesis and secretion","hsa04925",1,31,98,8377,0.306120078846862,0.54078591971311,2.75740618828176,0,"ATP2B1"]
["MAPK signaling pathway","hsa04010",2,31,300,8377,0.305453476235865,0.54078591971311,1.80150537634409,0,"NFATC3, PPM1A"]
["Huntington disease","hsa05016",2,31,294,8377,0.2971483760164,0.54078591971311,1.83827079218784,0,"KLC2, REST"]
["ATP-dependent chromatin remodeling","hsa03082",1,31,116,8377,0.351473142050945,0.549176784454601,2.32953281423804,0,"PHF6"]
["Human papillomavirus infection","hsa05165",2,31,332,8377,0.349451246861849,0.549176784454601,1.62786630392538,0,"COL9A2, COL9A3"]
["T cell receptor signaling pathway","hsa04660",1,31,122,8377,0.365943041337039,0.560116900005671,2.21496562665257,0,"NFATC3"]
["Yersinia infection","hsa05135",1,31,137,8377,0.400764150996685,0.569073111965527,1.97245114198258,0,"NFATC3"]
["Retrograde endocannabinoid signaling","hsa04723",1,31,141,8377,0.409732640615179,0.569073111965527,1.91649508121711,0,"SLC17A8"]
["Fluid shear stress and atherosclerosis","hsa05418",1,31,141,8377,0.409732640615179,0.569073111965527,1.91649508121711,0,"ACVR2A"]
["FoxO signaling pathway","hsa04068",1,31,133,8377,0.391663854866845,0.569073111965527,2.03177298083919,0,"HOMER2"]
["PI3K-Akt signaling pathway","hsa04151",2,31,361,8377,0.388624579168411,0.569073111965527,1.49709588061835,0,"COL9A2, COL9A3"]
["Efferocytosis","hsa04148",1,31,156,8377,0.442221800195661,0.584638272908671,1.73221670802316,0,"NFATC3"]
["Oxytocin signaling pathway","hsa04921",1,31,154,8377,0.43799208827088,0.584638272908671,1.75471302890658,0,"NFATC3"]
["Cellular senescence","hsa04218",1,31,157,8377,0.44432508741059,0.584638272908671,1.72118348058352,0,"NFATC3"]
["Hepatitis B","hsa05161",1,31,163,8377,0.456784554602767,0.590669682675992,1.65782703344548,0,"NFATC3"]
["Protein processing in endoplasmic reticulum","hsa04141",1,31,168,8377,0.466960528782596,0.59359389252025,1.60848694316436,0,"UBE2G1"]
["Lipid and atherosclerosis","hsa05417",1,31,215,8377,0.554021693431642,0.622081922949919,1.25686421605401,0,"NFATC3"]
["Human T-cell leukemia virus 1 infection","hsa05166",1,31,223,8377,0.567399501600815,0.622081922949919,1.21177491682338,0,"NFATC3"]
["cAMP signaling pathway","hsa04024",1,31,226,8377,0.572315369113925,0.622081922949919,1.19568940907793,0,"ATP2B1"]
["Pathogenic Escherichia coli infection","hsa05130",1,31,199,8377,0.526054666259516,0.622081922949919,1.35791862538499,0,"MYO6"]
["Thermogenesis","hsa04714",1,31,220,8377,0.562428973361083,0.622081922949919,1.2282991202346,0,"ACSL4"]
["Transcriptional misregulation in cancer","hsa05202",1,31,192,8377,0.513292177256119,0.622081922949919,1.40742607526882,0,"EWSR1"]
["Kaposi sarcoma-associated herpesvirus infection","hsa05167",1,31,196,8377,0.52062518973429,0.622081922949919,1.37870309414088,0,"NFATC3"]
["Pathways of neurodegeneration - multiple diseases","hsa05022",2,31,466,8377,0.521089478063405,0.622081922949919,1.15976740966357,0,"KLC2, UBE2G1"]
["Human immunodeficiency virus 1 infection","hsa05170",1,31,212,8377,0.548902515396523,0.622081922949919,1.27465003043214,0,"NFATC3"]
["Human cytomegalovirus infection","hsa05163",1,31,224,8377,0.569044168690633,0.622081922949919,1.20636520737327,0,"NFATC3"]
["Endocytosis","hsa04144",1,31,250,8377,0.60974303747572,0.653296111581129,1.08090322580645,0,"NEDD4L"]
["Prion disease","hsa05020",1,31,261,8377,0.625818739705294,0.661076133491508,1.03534791743913,0,"KLC2"]
["Cytokine-cytokine receptor interaction","hsa04060",1,31,296,8377,0.672818218699517,0.70085231114533,0.91292502179599,0,"ACVR2A"]
["Amyotrophic lateral sclerosis","hsa05014",1,31,354,8377,0.738404515620632,0.758634776322567,0.76334973573902,0,"KLC2"]
["Alzheimer disease","hsa05010",1,31,374,8377,0.757917194116967,0.76815931836179,0.72252889425565,0,"KLC2"]
["Metabolic pathways","hsa01100",3,31,1539,8377,0.942006528643221,0.942006528643221,0.526755957995347,0,"HSD17B4, ACSL4, CHSY1"]

{"sheet":"Supplementary Table S19.","index":19,"n_rows":72,"n_cols":11,"rows_kept":72}
["Supplementary Table S19.- Possible Transcription Factors according to CollecTRI in Homosapiens."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["SUPT3H","SUPT3H",1,25,1,6637,0.00376676209130631,0.259906584300136,265.48,0,"NEDD4L"]
["POU4F3","POU4F3",1,25,6,6637,0.0223971695350483,0.513278684539961,44.2466666666667,0,"MYO6"]
["ZNF335","ZNF335",1,25,8,6637,0.0297552860602876,0.513278684539961,33.185,0,"REST"]
["ZEB1","ZEB1",2,25,63,6637,0.0231215444840664,0.513278684539961,8.42793650793651,0,"REST, SEMA3F"]
["IRX1","IRX1",1,25,20,6637,0.0727999539331447,0.627899602673373,13.274,0,"COL9A3"]
["TOX","TOX",1,25,19,6637,0.0692841036143715,0.627899602673373,13.9726315789474,0,"TOX"]
["ZBTB7B","ZBTB7B",1,25,16,6637,0.0586595947370776,0.627899602673373,16.5925,0,"TOX"]
["NEUROD2","NEUROD2",1,25,13,6637,0.0479187070952924,0.627899602673373,20.4215384615385,0,"REST"]
["CREB1","CREB1",4,25,465,6637,0.0934684652852558,0.646038781787595,2.28369892473118,0,"NEDD4L, ACSL4, REST, NR2F1"]
["ESRRG","ESRRG",1,25,26,6637,0.093628808954724,0.646038781787595,10.2107692307692,0,"DNASE1"]
["MEF2C","MEF2C",1,25,90,6637,0.289617009132334,0.67636289193032,2.94977777777778,0,"NR2F1"]
["TAF1","TAF1",1,25,44,6637,0.153454864467836,0.67636289193032,6.03363636363636,0,"UBE2B"]
["RUNX3","RUNX3",1,25,69,6637,0.230291254387289,0.67636289193032,3.84753623188406,0,"DNASE1"]
["SNAI1","SNAI1",1,25,99,6637,0.313675544083627,0.67636289193032,2.68161616161616,0,"SEMA3F"]
["SMARCA1","SMARCA1",1,25,54,6637,0.185033966520475,0.67636289193032,4.9162962962963,0,"DNASE1"]
["GATA3","GATA3",2,25,194,6637,0.164909999014009,0.67636289193032,2.73690721649485,0,"ATP2B1, TOX"]
["TWIST1","TWIST1",1,25,78,6637,0.256276843826531,0.67636289193032,3.40358974358974,0,"NR2F1"]
["FOXM1","FOXM1",1,25,97,6637,0.308397768529461,0.67636289193032,2.73690721649485,0,"NFATC3"]
["NKX2-5","NKX2-5",1,25,74,6637,0.2448333982684,0.67636289193032,3.58756756756757,0,"NR2F1"]
["RORA","RORA",1,25,89,6637,0.286894400704971,0.67636289193032,2.98292134831461,0,"SEMA3F"]
["ID2","ID2",1,25,82,6637,0.267553715957032,0.67636289193032,3.23756097560976,0,"SEMA3F"]
["THRA","THRA",1,25,83,6637,0.270347180045677,0.67636289193032,3.19855421686747,0,"KCNE1"]
["EWSR1","EWSR1",1,25,59,6637,0.20039633047547,0.67636289193032,4.49966101694915,0,"EWSR1"]
["ATF1","ATF1",1,25,86,6637,0.278666339724589,0.67636289193032,3.08697674418605,0,"EWSR1"]
["NCOR2","NCOR2",1,25,69,6637,0.230291254387289,0.67636289193032,3.84753623188406,0,"NR2F1"]
["HES1","HES1",1,25,93,6637,0.297725091320608,0.67636289193032,2.85462365591398,0,"REST"]
["EGR2","EGR2",1,25,74,6637,0.2448333982684,0.67636289193032,3.58756756756757,0,"GJB3"]
["NR0B1","NR0B1",1,25,59,6637,0.20039633047547,0.67636289193032,4.49966101694915,0,"EWSR1"]
["CTNNB1","CTNNB1",3,25,340,6637,0.133697909610942,0.67636289193032,2.34247058823529,0,"NEDD4L, REST, UBE2B"]
["FLI1","FLI1",1,25,95,6637,0.303081042739351,0.67636289193032,2.79452631578947,0,"EWSR1"]
["TWIST2","TWIST2",1,25,35,6637,0.124032020393172,0.67636289193032,7.58514285714286,0,"NR2F1"]
["ESRRA","ESRRA",1,25,49,6637,0.169388476756443,0.67636289193032,5.41795918367347,0,"NR2F1"]
["SOX9","SOX9",1,25,105,6637,0.329277895579041,0.67822444095704,2.52838095238095,0,"COL9A2"]
["TFAP2A","TFAP2A",2,25,315,6637,0.334197550616513,0.67822444095704,1.6855873015873,0,"KCNE1, WDTC1"]
["RUNX2","RUNX2",1,25,129,6637,0.388349855566072,0.693998768966087,2.05798449612403,0,"TRAM2"]
["TCF3","TCF3",1,25,129,6637,0.388349855566072,0.693998768966087,2.05798449612403,0,"SEMA3F"]
["TCF7L2","TCF7L2",1,25,117,6637,0.359467296847774,0.693998768966087,2.26905982905983,0,"UBE2B"]
["SP1","SP1",6,25,1333,6637,0.387380662125371,0.693998768966087,1.19495873968492,0,"HSD17B4, KCNE1, ACSL4, EMB, REST, UBE2B"]
["KLF1","KLF1",1,25,133,6637,0.397696416052498,0.693998768966087,1.99609022556391,0,"DNASE1"]
["NR1H4","NR1H4",1,25,135,6637,0.402318126936862,0.693998768966087,1.96651851851852,0,"NISCH"]
["SSRP1","SSRP1",1,25,147,6637,0.429341577626281,0.702974886856036,1.80598639455782,0,"WDTC1"]
["MYOD1","MYOD1",1,25,144,6637,0.422697840412043,0.702974886856036,1.84361111111111,0,"DNASE1"]
["GLI2","GLI2",1,25,151,6637,0.438085799055211,0.702974886856036,1.75814569536424,0,"NR2F1"]
["SP3","SP3",2,25,449,6637,0.511970442059454,0.768633340077343,1.18253897550111,0,"REST, DNASE1"]
["TP53","TP53",4,25,976,6637,0.512422226718229,0.768633340077343,1.08803278688525,0,"ANKRD11, MYO6, UBE2B, PPM1A"]
["GLI1","GLI1",1,25,179,6637,0.495791570545794,0.768633340077343,1.48312849162011,0,"EMB"]
["FOXO3","FOXO3",1,25,196,6637,0.528004149419299,0.775155027870886,1.35448979591837,0,"SEMA3F"]
["CEBPG","CEBPG",1,25,205,6637,0.544248381956958,0.782357049063128,1.2950243902439,0,"WDTC1"]
["MYB","MYB",1,25,214,6637,0.559955172629314,0.788508304314748,1.24056074766355,0,"ATP2B1"]
["ETS1","ETS1",1,25,231,6637,0.58821714529691,0.795823196578173,1.14926406926407,0,"NR2F1"]
["NR1I2","NR1I2",1,25,231,6637,0.58821714529691,0.795823196578173,1.14926406926407,0,"UBE2B"]
["FOXO1","FOXO1",1,25,280,6637,0.660262868673542,0.828329780699534,0.948142857142857,0,"SEMA3F"]
["HNF4A","HNF4A",1,25,280,6637,0.660262868673542,0.828329780699534,0.948142857142857,0,"UBE2B"]
["YY1","YY1",1,25,264,6637,0.638184407227161,0.828329780699534,1.00560606060606,0,"REST"]
["PPARA","PPARA",1,25,269,6637,0.645227790918185,0.828329780699534,0.986914498141264,0,"HSD17B4"]
["STAT1","STAT1",1,25,304,6637,0.69097254914159,0.851376890906602,0.873289473684211,0,"REST"]
["AR","AR",4,25,1244,6637,0.716245091037421,0.867033531255825,0.853633440514469,0,"HSD17B4, REST, UBE2B, DNASE1"]
["FOS","FOS",1,25,403,6637,0.791741735966215,0.941899651408084,0.658759305210918,0,"UBE2B"]
["HIF1A","HIF1A",1,25,460,6637,0.834545355631041,0.942648916974032,0.577130434782609,0,"DNASE1"]
["REL","REL",2,25,986,6637,0.904227950942936,0.942648916974032,0.538498985801217,0,"CLPP, WDTC1"]
["NFKB1","NFKB1",2,25,932,6637,0.884769133029906,0.942648916974032,0.569699570815451,0,"UBE2B, WDTC1"]
["MYC","MYC",2,25,968,6637,0.898090974005022,0.942648916974032,0.548512396694215,0,"ACSL4, NFATC3"]
["JUNB","JUNB",1,25,620,6637,0.914261312383287,0.942648916974032,0.428193548387097,0,"DNASE1"]
["JUND","JUND",1,25,623,6637,0.915325759960292,0.942648916974032,0.426131621187801,0,"DNASE1"]
["JUN","JUN",2,25,930,6637,0.883986191506335,0.942648916974032,0.570924731182796,0,"UBE2B, DNASE1"]
["STAT3","STAT3",1,25,434,6637,0.816188744377812,0.942648916974032,0.611705069124424,0,"UBE2G1"]
["RELB","RELB",2,25,812,6637,0.828796212782006,0.942648916974032,0.653891625615764,0,"CLPP, WDTC1"]
["NFKB2","NFKB2",1,25,816,6637,0.962598810656037,0.976754675518626,0.325343137254902,0,"WDTC1"]
["RELA","RELA",1,25,960,6637,0.980031362863126,0.980031362863126,0.276541666666667,0,"WDTC1"]

{"sheet":"Supplementary Table S20.","index":20,"n_rows":557,"n_cols":11,"rows_kept":557}
["Supplementary Table S20.- Active biochemical pathways according to Gene Ontology - Biological Processes in Mus musculus."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["sensory perception of sound","GO:0007605",17,70,273,25033,{"v":1.24275035845853e-18,"d":"1.24E-18"},{"v":6.88483698586023e-16,"d":"6.88E-16"},22.2690214547357,0,"Tprn, Tmtc4, Cabp2, Grxcr1, Marveld2, Myo3a, Slc17a8, Spns2, Triobp, Ush1c, Otog, Otogl, Otoa, Myo6, Clrn1, Homer2, Eps8l2"]
["auditory receptor cell stereocilium organization","GO:0060088",5,70,25,25033,{"v":7.51986176804754e-09,"d":"7.52E-09"},{"v":2.08300170974917e-06,"d":"2.08E-06"},71.5228571428572,0,"Tprn, Rest, Myo3a, Triobp, Clrn1"]
["inner ear receptor cell stereocilium organization","GO:0060122",4,70,33,25033,{"v":2.15745956857592e-06,"d":"2.16E-06"},3.9841086699702E-4,43.3471861471862,0,"Grxcr1, Ush1c, Otog, Otogl"]
["vibrational conductance of sound to the inner ear","GO:0055127",2,70,2,25033,{"v":7.7079463162317e-06,"d":"7.71E-06"},0.000854040451838473,357.614285714286,0,"Otog, Otogl"]
["L-arabinose metabolic process","GO:0046373",2,70,2,25033,{"v":7.7079463162317e-06,"d":"7.71E-06"},0.000854040451838473,357.614285714286,0,"Otog, Otogl"]
["protein localization","GO:0008104",6,70,214,25033,{"v":3.02449819592428e-05,"d":"3.02E-05"},0.00279262000090342,10.0265687583445,0,"Gga1, Otog, Otogl, Myo6, Elmod1, Nin"]
["inner ear auditory receptor cell differentiation","GO:0042491",3,70,24,25033,{"v":4.0632237259298e-05,"d":"4.06E-05"},0.0032157513488073,44.7017857142857,0,"Grxcr1, Ush1c, Myo6"]
["Rac protein signal transduction","GO:0016601",3,70,27,25033,{"v":5.83678573679223e-05,"d":"5.84E-05"},0.00404197412272862,39.7349206349206,0,"Nisch, Eps8l1, Eps8l2"]
["synaptic vesicle coating","GO:0016183",2,70,5,25033,{"v":7.66615103597563e-05,"d":"7.67E-05"},0.00471894185992278,143.045714285714,0,"Ap3m2, Ap3s1"]
["cochlea development","GO:0090102",3,70,38,25033,0.00016466938219675,0.00829334888518176,28.2327067669173,0,"Grxcr1, Slc17a8, Ocm"]
["clathrin-coated vesicle cargo loading, AP-3-mediated","GO:0035654",2,70,7,25033,1.60406970176485E-4,0.00829334888518176,102.175510204082,0,"Ap3m2, Ap3s1"]
["equilibrioception","GO:0050957",2,70,8,25033,2.13488993842421E-4,0.00985607521572508,89.4035714285714,0,"Ush1c, Clrn1"]
["actin filament bundle assembly","GO:0051017",3,70,44,25033,0.000255434323009867,0.0108854319190359,24.3827922077922,0,"Baiap2l2, Triobp, Ush1c"]
["photoreceptor cell maintenance","GO:0045494",3,70,47,25033,0.000310863816233293,0.0123013252995175,22.826443768997,0,"Ush1c, Cib2, Clrn1"]
["Golgi to vacuole transport","GO:0006896",2,70,10,25033,0.000341867232059922,0.0126262964374131,71.5228571428571,0,"Ap3s1, Vti1a"]
["sensory perception of light stimulus","GO:0050953",2,70,13,25033,0.000589361805326091,0.0192062611853326,55.0175824175824,0,"Ush1c, Clrn1"]
["synaptic vesicle recycling","GO:0036465",2,70,13,25033,0.000589361805326091,0.0192062611853326,55.0175824175824,0,"Ap3m2, Ap3s1"]
["cellular component organization","GO:0016043",2,70,15,25033,0.000790507045773848,0.0212994561714478,47.6819047619048,0,"Otog, Otogl"]
["visual perception","GO:0007601",4,70,152,25033,0.000877622192391989,0.0212994561714478,9.4109022556391,0,"Cabp2, Slc4a10, Myo3a, Clrn1"]
["intracellular protein transport","GO:0006886",5,70,265,25033,0.000884273451161191,0.0212994561714478,6.74743935309973,0,"Ap3m2, Mpdz, Ap3s1, Gga1, Vti1a"]
["neuromuscular process controlling balance","GO:0050885",3,70,66,25033,0.000844594949455228,0.0212994561714478,16.2551948051948,0,"Rest, Ush1c, Clrn1"]
["positive regulation of ruffle assembly","GO:1900029",2,70,15,25033,0.000790507045773848,0.0212994561714478,47.6819047619048,0,"Eps8l1, Eps8l2"]
["cellular response to electrical stimulus","GO:0071257",2,70,15,25033,0.000790507045773848,0.0212994561714478,47.6819047619048,0,"Rest, Myo6"]
["inner ear development","GO:0048839",3,70,70,25033,1.00230479410215E-3,0.0226076175063851,15.3263265306122,0,"Grxcr1, Myo3a, Myo6"]
["ventricular cardiac muscle cell action potential","GO:0086005",2,70,17,25033,1.02019934595601E-3,0.0226076175063851,42.072268907563,0,"Kcne1, Nedd4l"]
["multicellular organism growth","GO:0035264",4,70,161,25033,1.0864990193013E-3,0.0231507867958815,8.88482697426797,0,"Ankrd11, Slc4a10, Wdtc1, Otoa"]
["regulation of store-operated calcium entry","GO:2001256",2,70,18,25033,0.00114565179760699,0.023507077624973,39.7349206349206,0,"Homer2, Nfatc3"]
["anterograde synaptic vesicle transport","GO:0048490",2,70,19,25033,0.00127812271882853,0.0252885709368217,37.6436090225564,0,"Ap3m2, Ap3s1"]
["negative regulation of dense core granule biogenesis","GO:2000706",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Rest"]
["intracellular chemical homeostasis","GO:0055082",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Wdtc1"]
["very long-chain fatty-acyl-CoA metabolic process","GO:0036111",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Hsd17b4"]
["regulation of Rho protein signal transduction","GO:0035023",2,70,25,25033,0.00221815757163942,0.0368846456011398,28.6091428571429,0,"Eps8l1, Eps8l2"]
["regulation of receptor localization to synapse","GO:1902683",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Nptn"]
["negative regulation of amniotic stem cell differentiation","GO:2000798",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Rest"]
["vestibular receptor cell development","GO:0060118",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Grxcr1"]
["medium-chain fatty-acyl-CoA metabolic process","GO:0036112",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Hsd17b4"]
["protein transport","GO:0015031",7,70,645,25033,0.00214757122115,0.0368846456011398,3.88108527131783,0,"Ap3m2, Ap3s1, Gga1, Vti1a, Tram2, Myo6, Elmod1"]
["protein K48-linked ubiquitination","GO:0070936",3,70,99,25033,0.00271070933574031,0.0368846456011398,10.8367965367965,0,"Ube2g1, Ube2b, Nedd4l"]
["regulation of acetylcholine uptake","GO:0051631",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Slc17a8"]
["monoatomic anion transport","GO:0006820",2,70,28,25033,0.00277979267279182,0.0368846456011398,25.5438775510204,0,"Slc4a10, Slc17a8"]
["regulation of eye pigmentation","GO:0048073",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Spns2"]
["NK T cell lineage commitment","GO:0002364",1,70,1,25033,0.00279630887228858,0.0368846456011398,357.614285714286,0,"Tox"]
["negative regulation of miRNA transcription","GO:1902894",2,70,29,25033,2.98032374569522E-3,0.0383976594212827,24.6630541871921,0,"Rest, Nfatc3"]
["anterograde axonal transport","GO:0008089",2,70,32,25033,0.00362134950177334,0.045596082363237,22.3508928571429,0,"Ap3m2, Ap3s1"]
["lymph node development","GO:0048535",2,70,33,25033,0.00384804481232247,0.0473737072450367,21.6735930735931,0,"Spns2, Tox"]
["CD8-positive, alpha-beta T cell lineage commitment","GO:0043375",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Tox"]
["centrosome-templated microtubule nucleation","GO:0090222",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Nin"]
["CD4-positive, alpha-beta T cell lineage commitment","GO:0043373",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Tox"]
["positive regulation of glutamate uptake involved in transmission of nerve impulse","GO:0051951",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Slc17a8"]
["norepinephrine secretion","GO:0048243",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Nisch"]
["regulation of neutrophil mediated cytotoxicity","GO:0070948",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Dnase1"]
["regulation of humoral immune response","GO:0002920",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Spns2"]
["penile erection","GO:0043084",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Acvr2a"]
["negative regulation of prostaglandin secretion","GO:0032307",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Acsl4"]
["respiratory basal cell differentiation","GO:1902691",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Ccdc88c"]
["histidyl-tRNA aminoacylation","GO:0006427",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Hars2"]
["protein localization to microvillus","GO:1904106",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Ush1c"]
["regulation of positive thymic T cell selection","GO:1902232",1,70,2,25033,0.00558490979826093,0.052441356410789,178.807142857143,0,"Tox"]
["negative regulation of cytokine production","GO:0001818",2,70,38,25033,0.00507751318922517,0.052441356410789,18.8218045112782,0,"Nptn, Atp2b1"]
["intracellular transport","GO:0046907",2,70,42,25033,0.00617409579153307,0.0570074844751553,17.0292517006803,0,"Ap3m2, Ap3s1"]
["protein catabolic process","GO:0030163",3,70,137,25033,0.00671868064591363,0.0610188373415763,7.83096976016684,0,"Ube2g1, Ankrd11, Gga1"]
["sodium ion transport","GO:0006814",3,70,144,25033,0.00770297440769675,0.063488579993582,7.45029761904762,0,"Slc4a10, Slc17a8, Nedd4l"]
["vestibular nucleus development","GO:0021750",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Kcne1"]
["outer hair cell apoptotic process","GO:1905584",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Tmtc4"]
["positive regulation of mitotic cell cycle phase transition","GO:1901992",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Klhl18"]
["positive regulation of reciprocal meiotic recombination","GO:0010845",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Ube2b"]
["trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission","GO:0099557",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Nptn"]
["positive regulation of endoplasmic reticulum calcium ion concentration","GO:0032470",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Tmtc4"]
["negative regulation of sodium ion transmembrane transport","GO:1902306",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Nedd4l"]
["synaptonemal complex organization","GO:0070193",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Ube2b"]
["CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment","GO:0002362",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Tox"]
["negative regulation of mesenchymal stem cell differentiation","GO:2000740",1,70,3,25033,0.00836582371756586,0.063488579993582,119.204761904762,0,"Rest"]
["positive regulation of bone mineralization","GO:0030501",2,70,46,25033,0.00736864400506388,0.063488579993582,15.5484472049689,0,"Atp2b1, Acvr2a"]
["male gonad development","GO:0008584",3,70,154,25033,0.00924989773321673,0.0663638913343828,6.9665120593692,0,"Kcne1, Col9a3, Acvr2a"]
["calcium ion export","GO:1901660",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Atp2b1"]
["negative regulation of protein localization to centrosome","GO:1904780",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Nin"]
["negative regulation of post-translational protein modification","GO:1901874",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Ube2b"]
["regulation of acute inflammatory response","GO:0002673",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Dnase1"]
["parallel actin filament bundle assembly","GO:0030046",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Ush1c"]
["stereocilium maintenance","GO:0120045",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Tprn"]
["negative regulation of cortisol biosynthetic process","GO:2000065",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Rest"]
["modification of synaptic structure","GO:0099563",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Rest"]
["negative regulation of aldosterone biosynthetic process","GO:0032348",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Rest"]
["ventral trunk neural crest cell migration","GO:0036486",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Sema3f"]
["trunk neural crest cell migration","GO:0036484",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Sema3f"]
["N-terminal protein myristoylation","GO:0006499",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Ppm1a"]
["positive regulation of caveolin-mediated endocytosis","GO:2001288",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Nedd4l"]
["vesicle-mediated transport","GO:0016192",4,70,292,25033,0.0091009212877709,0.0663638913343828,4.89882583170254,0,"Ap3m2, Ap3s1, Gga1, Vti1a"]
["sympathetic neuron projection guidance","GO:0097491",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Sema3f"]
["plasma membrane lactate transport","GO:0035879",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Emb"]
["dendrite development","GO:0016358",2,70,57,25033,0.0111405088341112,0.0663638913343828,12.5478696741855,0,"Mpdz, Myo6"]
["regulation of actin filament length","GO:0030832",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Myo3a"]
["DN4 thymocyte differentiation","GO:1904157",1,70,4,25033,0.0111390715138012,0.0663638913343828,89.4035714285714,0,"Nfatc3"]
["cellular response to oxygen-glucose deprivation","GO:0090650",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Acvr2a"]
["positive regulation of artery morphogenesis","GO:1905653",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Nfatc3"]
["negative regulation of vascular associated smooth muscle cell differentiation","GO:1905064",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Nfatc3"]
["synaptic vesicle to endosome fusion","GO:0016189",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Vti1a"]
["apical constriction","GO:0003383",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Ccdc88c"]
["Rho protein signal transduction","GO:0007266",2,70,64,25033,0.013896833698624,0.0740691288857932,11.1754464285714,0,"Eps8l1, Eps8l2"]
["trigeminal nerve structural organization","GO:0021637",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Sema3f"]
["regulation of vascular associated smooth muscle contraction","GO:0003056",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Atp2b1"]
["protein localization to ciliary membrane","GO:1903441",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Gga1"]
["lymphocyte migration","GO:0072676",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Spns2"]
["positive regulation of follicle-stimulating hormone secretion","GO:0046881",1,70,5,25033,0.0139046740146615,0.0740691288857932,71.5228571428571,0,"Acvr2a"]
["protein K63-linked ubiquitination","GO:0070534",2,70,66,25033,0.0147332256833717,0.0777353050341707,10.8367965367965,0,"Ube2g1, Ube2b"]
["negative regulation of potassium ion transmembrane transporter activity","GO:1901017",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Nedd4l"]
["presynaptic endocytosis","GO:0140238",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Aak1"]
["regulation of secretion","GO:0051046",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Myo6"]
["calcium ion export across plasma membrane","GO:1990034",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Atp2b1"]
["leptotene","GO:0000237",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Ube2b"]
["branchiomotor neuron axon guidance","GO:0021785",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Sema3f"]
["regulation of delayed rectifier potassium channel activity","GO:1902259",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Kcne1"]
["sympathetic neuron projection extension","GO:0097490",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Sema3f"]
["membrane repolarization during cardiac muscle cell action potential","GO:0086013",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Kcne1"]
["secretory granule organization","GO:0033363",1,70,6,25033,0.0166626519920858,0.0788983692616712,59.602380952381,0,"Kcne1"]
["odontogenesis of dentin-containing tooth","GO:0042475",2,70,68,25033,0.0155908617149004,0.0788983692616712,10.5180672268908,0,"Ankrd11, Acvr2a"]
["anatomical structure morphogenesis","GO:0009653",2,70,70,25033,0.0164694855334177,0.0788983692616712,10.2175510204082,0,"Ankrd11, Sema3f"]
["in utero embryonic development","GO:0001701",4,70,351,25033,0.0168761735588932,0.0792322046748034,4.07537647537648,0,"Gjb3, Ube2b, Ankrd11, Wdtc1"]
["negative regulation of protein targeting to membrane","GO:0090315",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Kcne1"]
["protein ubiquitination","GO:0016567",5,70,548,25033,0.0186351705414306,0.0808632819095625,3.26290406673618,0,"Ube2g1, Klhl18, Ube2b, Wdtc1, Nedd4l"]
["localization of cell","GO:0051674",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Ankrd11"]
["neurotransmitter loading into synaptic vesicle","GO:0098700",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Slc17a8"]
["inner ear morphogenesis","GO:0042472",2,70,75,25033,0.0187562041026034,0.0808632819095625,9.53638095238095,0,"Ush1c, Myo6"]
["regulation of potassium ion transmembrane transporter activity","GO:1901016",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Nedd4l"]
["auditory receptor cell morphogenesis","GO:0002093",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Ush1c"]
["long-chain fatty-acyl-CoA metabolic process","GO:0035336",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Acsl4"]
["somatic stem cell population maintenance","GO:0035019",2,70,75,25033,0.0187562041026034,0.0808632819095625,9.53638095238095,0,"Rest, Med28"]
["regulation of microvillus length","GO:0032532",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Ush1c"]
["retrograde transport, endosome to Golgi","GO:0042147",2,70,76,25033,0.0192287529401086,0.0808632819095625,9.4109022556391,0,"Gga1, Vti1a"]
["neural crest cell migration involved in autonomic nervous system development","GO:1901166",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Sema3f"]
["myotube cell development","GO:0014904",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Nfatc3"]
["sperm ejaculation","GO:0042713",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Acvr2a"]
["neutrophil activation involved in immune response","GO:0002283",1,70,7,25033,0.019413026162404,0.0808632819095625,51.0877551020408,0,"Dnase1"]
["tight junction assembly","GO:0120192",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Mpdz"]
["postreplication repair","GO:0006301",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Ube2b"]
["corpus callosum morphogenesis","GO:0021540",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Nin"]
["brush border assembly","GO:1904970",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Ush1c"]
["Sertoli cell proliferation","GO:0060011",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Acvr2a"]
["membrane repolarization during ventricular cardiac muscle cell action potential","GO:0098915",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Kcne1"]
["L-glutamate import","GO:0051938",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Slc17a8"]
["positive regulation of activin receptor signaling pathway","GO:0032927",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Acvr2a"]
["excitatory synapse assembly","GO:1904861",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Nptn"]
["corticospinal tract morphogenesis","GO:0021957",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Nin"]
["inorganic ion transmembrane transport","GO:0098660",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Slc4a10"]
["regulation of nitric oxide biosynthetic process","GO:0045428",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Acvr2a"]
["regulation of synapse structure or activity","GO:0050803",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Slc17a8"]
["regulation of T cell migration","GO:2000404",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Spns2"]
["negative regulation of sodium ion transmembrane transporter activity","GO:2000650",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Nedd4l"]
["sodium-dependent phosphate transport","GO:0044341",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Slc17a8"]
["glucose metabolic process","GO:0006006",2,70,78,25033,0.0201888076387556,0.081286905439154,9.16959706959707,0,"Nisch, Wdtc1"]
["negative regulation of sodium ion transport","GO:0010766",1,70,8,25033,0.0221558171864842,0.081286905439154,44.7017857142857,0,"Nedd4l"]
["regulation of blood pressure","GO:0008217",2,70,83,25033,0.0226747660109301,0.0826435550661531,8.61721170395869,0,"Nisch, Atp2b1"]
["sympathetic ganglion development","GO:0061549",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Sema3f"]
["response to stimulus","GO:0050896",3,70,222,25033,0.0243838828797757,0.0835735715218957,4.83262548262548,0,"Cabp2, Myo3a, Clrn1"]
["endocytosis","GO:0006897",3,70,218,25033,0.0232654844819212,0.0835735715218957,4.92129750982962,0,"Ap3m2, Aak1, Myo6"]
["regulation of cellular pH","GO:0030641",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Slc4a10"]
["vesicle fusion with Golgi apparatus","GO:0048280",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Vti1a"]
["leukocyte differentiation","GO:0002521",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Tox"]
["protein insertion into ER membrane","GO:0045048",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Tram2"]
["cardiac muscle cell contraction","GO:0086003",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Kcne1"]
["membrane repolarization during action potential","GO:0086011",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Kcne1"]
["negative regulation of delayed rectifier potassium channel activity","GO:1902260",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Kcne1"]
["voluntary musculoskeletal movement","GO:0050882",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Vti1a"]
["chiasma assembly","GO:0051026",1,70,9,25033,0.0248910456698787,0.0835735715218957,39.7349206349206,0,"Ube2b"]
["positive regulation of protein catabolic process","GO:0045732",2,70,84,25033,0.0231864275184995,0.0835735715218957,8.51462585034014,0,"Gga1, Nedd4l"]
["inner ear receptor cell development","GO:0060119",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Grxcr1"]
["cerebral cortex regionalization","GO:0021796",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Nr2f1"]
["negative regulation of calcium ion-dependent exocytosis","GO:0045955",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Rest"]
["negative regulation of smooth muscle cell differentiation","GO:0051151",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Med28"]
["negative regulation of transcription regulatory region DNA binding","GO:2000678",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Rest"]
["head morphogenesis","GO:0060323",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Ankrd11"]
["SRP-dependent cotranslational protein targeting to membrane, translocation","GO:0006616",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Tram2"]
["positive regulation of fibroblast growth factor receptor signaling pathway","GO:0045743",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Nptn"]
["regulation protein catabolic process at postsynapse","GO:0140252",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Nedd4l"]
["axo-dendritic transport","GO:0008088",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Klc2"]
["long-chain fatty-acyl-CoA biosynthetic process","GO:0035338",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Acsl4"]
["auditory receptor cell development","GO:0060117",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Clrn1"]
["pyramidal neuron development","GO:0021860",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Slc4a10"]
["positive regulation of cation channel activity","GO:2001259",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Nedd4l"]
["facial nerve structural organization","GO:0021612",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Sema3f"]
["embryonic process involved in female pregnancy","GO:0060136",1,70,10,25033,0.0276187321629696,0.0845346829739513,35.7614285714286,0,"Acsl4"]
["phosphate ion transport","GO:0006817",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Slc17a8"]
["regulation of cellular response to insulin stimulus","GO:1900076",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Atp2b1"]
["Peyer's patch development","GO:0048541",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Tox"]
["negative regulation of axon extension involved in axon guidance","GO:0048843",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Sema3f"]
["vascular associated smooth muscle cell development","GO:0097084",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Nfatc3"]
["bone development","GO:0060348",2,70,96,25033,0.0296886926554198,0.0857538215676415,7.45029761904762,0,"Ankrd11, Spns2"]
["negative regulation of potassium ion transmembrane transport","GO:1901380",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Nedd4l"]
["epithelial cell maturation","GO:0002070",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Kcne1"]
["negative regulation of reproductive process","GO:2000242",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Ube2b"]
["positive regulation of long-term neuronal synaptic plasticity","GO:0048170",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Nptn"]
["microtubule anchoring at centrosome","GO:0034454",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Nin"]
["regulation of clathrin-dependent endocytosis","GO:2000369",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Aak1"]
["regulation of sodium ion transmembrane transport","GO:1902305",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Nedd4l"]
["vascular associated smooth muscle cell differentiation","GO:0035886",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Nfatc3"]
["meiotic telomere clustering","GO:0045141",1,70,11,25033,0.030338897161115,0.0857538215676415,32.5103896103896,0,"Ube2b"]
["regulation of bicellular tight junction assembly","GO:2000810",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Nedd4l"]
["dendrite self-avoidance","GO:0070593",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Emb"]
["negative regulation of protein localization to cell surface","GO:2000009",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Nedd4l"]
["positive regulation of natural killer cell differentiation","GO:0032825",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Tox"]
["collagen biosynthetic process","GO:0032964",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Tram2"]
["cardiac muscle cell myoblast differentiation","GO:0060379",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Rest"]
["negative regulation by host of viral transcription","GO:0043922",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Rest"]
["axon extension involved in axon guidance","GO:0048846",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Sema3f"]
["centriole-centriole cohesion","GO:0010457",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Nin"]
["interneuron migration","GO:1904936",1,70,12,25033,0.0330515611047935,0.0888862371459009,29.8011904761905,0,"Nr2f1"]
["proteasome-mediated ubiquitin-dependent protein catabolic process","GO:0043161",3,70,253,25033,0.034023670829061,0.0910585199966175,4.24048560135517,0,"Ube2g1, Ube2b, Nedd4l"]
["regulation of membrane repolarization","GO:0060306",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Nedd4l"]
["mucociliary clearance","GO:0120197",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Ccdc88c"]
["membrane repolarization","GO:0086009",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Kcne1"]
["negative regulation of developmental process","GO:0051093",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Ube2b"]
["cellular response to acidic pH","GO:0071468",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Kcne1"]
["regulation of membrane depolarization","GO:0003254",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Nedd4l"]
["postsynaptic neurotransmitter receptor internalization","GO:0098884",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Myo6"]
["glutamate secretion","GO:0014047",1,70,13,25033,0.0357567443797491,0.0921359831924697,27.5087912087912,0,"Myo6"]
["positive regulation of neuron differentiation","GO:0045666",2,70,110,25033,0.0380730973446067,0.0959629499715914,6.50207792207792,0,"Rest, Nin"]
["regulation of fatty acid metabolic process","GO:0019217",1,70,14,25033,0.0384544673171359,0.0959629499715914,25.5438775510204,0,"Acsl4"]
["regulation of potassium ion transport","GO:0043266",1,70,14,25033,0.0384544673171359,0.0959629499715914,25.5438775510204,0,"Kcne1"]
["response to salt stress","GO:0009651",1,70,14,25033,0.0384544673171359,0.0959629499715914,25.5438775510204,0,"Nedd4l"]
["membrane protein proteolysis","GO:0033619",1,70,14,25033,0.0384544673171359,0.0959629499715914,25.5438775510204,0,"Clpp"]
["protein quality control for misfolded or incompletely synthesized proteins","GO:0006515",1,70,14,25033,0.0384544673171359,0.0959629499715914,25.5438775510204,0,"Clpp"]
["positive regulation of canonical Wnt signaling pathway","GO:0090263",2,70,109,25033,0.0374472079782695,0.0959629499715914,6.56173001310616,0,"Ube2b, Ppm1a"]
["negative regulation of cAMP-mediated signaling","GO:0043951",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Ube2b"]
["peptidyl-threonine dephosphorylation","GO:0035970",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Ppm1a"]
["actin crosslink formation","GO:0051764",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Baiap2l2"]
["cellular response to light stimulus","GO:0071482",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Kcne1"]
["DNA catabolic process","GO:0006308",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Dnase1"]
["cardiac muscle cell action potential involved in contraction","GO:0086002",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Kcne1"]
["sphingosine-1-phosphate receptor signaling pathway","GO:0003376",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Spns2"]
["cellular response to ATP","GO:0071318",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Cib2"]
["positive thymic T cell selection","GO:0045059",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Nfatc3"]
["lymphocyte differentiation","GO:0030098",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Tox"]
["positive regulation of protein localization","GO:1903829",1,70,15,25033,0.0411447501936617,0.0978291485291356,23.8409523809524,0,"Nptn"]
["inorganic anion transport","GO:0015698",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Slc4a10"]
["G protein-coupled glutamate receptor signaling pathway","GO:0007216",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Homer2"]
["positive regulation of programmed cell death","GO:0043068",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Rest"]
["protein acetylation","GO:0006473",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Ankrd11"]
["intracellular calcium ion homeostasis","GO:0006874",2,70,118,25033,0.0432226625789501,0.100332635249502,6.06125907990315,0,"Nptn, Atp2b1"]
["positive regulation of potassium ion transmembrane transport","GO:1901381",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Kcne1"]
["cytoskeleton-dependent intracellular transport","GO:0030705",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Ccdc88c"]
["negative regulation of calcineurin-NFAT signaling cascade","GO:0070885",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Homer2"]
["lymphocyte homeostasis","GO:0002260",1,70,16,25033,0.0438276132317321,0.100332635249502,22.3508928571429,0,"Spns2"]
["negative regulation of fatty acid biosynthetic process","GO:0045717",1,70,17,25033,0.0465030765995931,0.1034646764505,21.0361344537815,0,"Wdtc1"]
["potassium ion export across plasma membrane","GO:0097623",1,70,17,25033,0.0465030765995931,0.1034646764505,21.0361344537815,0,"Kcne1"]
["Sertoli cell development","GO:0060009",1,70,17,25033,0.0465030765995931,0.1034646764505,21.0361344537815,0,"Hsd17b4"]
["regulation of synaptic transmission, GABAergic","GO:0032228",1,70,17,25033,0.0465030765995931,0.1034646764505,21.0361344537815,0,"Nisch"]
["collateral sprouting","GO:0048668",1,70,17,25033,0.0465030765995931,0.1034646764505,21.0361344537815,0,"Nin"]
["protein O-linked mannosylation","GO:0035269",1,70,17,25033,0.0465030765995931,0.1034646764505,21.0361344537815,0,"Tmtc4"]
["phosphate ion homeostasis","GO:0055062",1,70,17,25033,0.0465030765995931,0.1034646764505,21.0361344537815,0,"Slc17a8"]
["retinal cone cell development","GO:0046549",1,70,18,25033,0.0491711604114747,0.108529174772737,19.8674603174603,0,"Ush1c"]
["cellular response to lithium ion","GO:0071285",1,70,18,25033,0.0491711604114747,0.108529174772737,19.8674603174603,0,"Nfatc3"]
["melanosome assembly","GO:1903232",1,70,19,25033,0.0518318847277327,0.112607310349662,18.8218045112782,0,"Ap3s1"]
["cerebral cortex neuron differentiation","GO:0021895",1,70,19,25033,0.0518318847277327,0.112607310349662,18.8218045112782,0,"Tox"]
["neural retina development","GO:0003407",1,70,19,25033,0.0518318847277327,0.112607310349662,18.8218045112782,0,"Slc17a8"]
["DNA damage response, signal transduction by p53 class mediator","GO:0030330",1,70,19,25033,0.0518318847277327,0.112607310349662,18.8218045112782,0,"Myo6"]
["calcineurin-NFAT signaling cascade","GO:0033173",1,70,20,25033,0.0544852695549918,0.115209310433074,17.8807142857143,0,"Nfatc3"]
["very long-chain fatty acid metabolic process","GO:0000038",1,70,20,25033,0.0544852695549918,0.115209310433074,17.8807142857143,0,"Hsd17b4"]
["activin receptor signaling pathway","GO:0032924",1,70,20,25033,0.0544852695549918,0.115209310433074,17.8807142857143,0,"Acvr2a"]
["actin filament-based movement","GO:0030048",1,70,20,25033,0.0544852695549918,0.115209310433074,17.8807142857143,0,"Myo6"]
["Wnt signaling pathway, planar cell polarity pathway","GO:0060071",1,70,20,25033,0.0544852695549918,0.115209310433074,17.8807142857143,0,"Ccdc88c"]
["chondroitin sulfate biosynthetic process","GO:0030206",1,70,20,25033,0.0544852695549918,0.115209310433074,17.8807142857143,0,"Chsy1"]
["sodium ion transmembrane transport","GO:0035725",2,70,133,25033,0.0535249660738012,0.115209310433074,5.37765843179377,0,"Slc4a10, Slc17a8"]
["regulation of short-term neuronal synaptic plasticity","GO:0048172",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Slc4a10"]
["establishment of endothelial barrier","GO:0061028",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Marveld2"]
["regulation of ventricular cardiac muscle cell membrane repolarization","GO:0060307",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Kcne1"]
["locomotory exploration behavior","GO:0035641",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Slc4a10"]
["centrosome localization","GO:0051642",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Nin"]
["positive regulation of protein export from nucleus","GO:0046827",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Ppm1a"]
["negative regulation of cytosolic calcium ion concentration","GO:0051481",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Atp2b1"]
["ectopic germ cell programmed cell death","GO:0035234",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Ube2b"]
["androgen metabolic process","GO:0008209",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Hsd17b4"]
["regulation of osteoblast differentiation","GO:0045667",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Rest"]
["platelet dense granule organization","GO:0060155",1,70,21,25033,0.0571313348462864,0.115936848003087,17.0292517006803,0,"Ap3s1"]
["negative regulation of transcription by RNA polymerase II","GO:0000122",6,70,993,25033,0.0589855708023262,0.119110200279375,2.16081139404402,0,"Rest, Nr2f1, Phf6, Wdtc1, Ikzf5, Nfatc3"]
["L-glutamate transmembrane transport","GO:0015813",1,70,22,25033,0.0597701005012024,0.119110200279375,16.2551948051948,0,"Slc17a8"]
["detection of mechanical stimulus involved in sensory perception of sound","GO:0050910",1,70,22,25033,0.0597701005012024,0.119110200279375,16.2551948051948,0,"Rest"]
["triglyceride biosynthetic process","GO:0019432",1,70,22,25033,0.0597701005012024,0.119110200279375,16.2551948051948,0,"Acsl4"]
["negative regulation of systemic arterial blood pressure","GO:0003085",1,70,22,25033,0.0597701005012024,0.119110200279375,16.2551948051948,0,"Nedd4l"]
["cell surface receptor protein serine/threonine kinase signaling pathway","GO:0007178",1,70,23,25033,0.0624015863660186,0.121299925778155,15.5484472049689,0,"Acvr2a"]
["dendritic spine development","GO:0060996",1,70,23,25033,0.0624015863660186,0.121299925778155,15.5484472049689,0,"Acsl4"]
["chondrocyte development","GO:0002063",1,70,23,25033,0.0624015863660186,0.121299925778155,15.5484472049689,0,"Chsy1"]
["face development","GO:0060324",1,70,23,25033,0.0624015863660186,0.121299925778155,15.5484472049689,0,"Ankrd11"]
["behavioral response to cocaine","GO:0048148",1,70,23,25033,0.0624015863660186,0.121299925778155,15.5484472049689,0,"Homer2"]
["bicarbonate transport","GO:0015701",1,70,23,25033,0.0624015863660186,0.121299925778155,15.5484472049689,0,"Slc4a10"]
["cardiac muscle hypertrophy in response to stress","GO:0014898",1,70,23,25033,0.0624015863660186,0.121299925778155,15.5484472049689,0,"Nfatc3"]
["outer dynein arm assembly","GO:0036158",1,70,24,25033,0.0650258122338466,0.12379484528368,14.9005952380952,0,"Nisch"]
["myotube differentiation","GO:0014902",1,70,24,25033,0.0650258122338466,0.12379484528368,14.9005952380952,0,"Nfatc3"]
["plasma membrane organization","GO:0007009",1,70,24,25033,0.0650258122338466,0.12379484528368,14.9005952380952,0,"Baiap2l2"]
["regulation of monoatomic ion transmembrane transport","GO:0034765",1,70,24,25033,0.0650258122338466,0.12379484528368,14.9005952380952,0,"Nedd4l"]
["heart contraction","GO:0060047",1,70,24,25033,0.0650258122338466,0.12379484528368,14.9005952380952,0,"Kcne1"]
["regulation of sodium ion transport","GO:0002028",1,70,24,25033,0.0650258122338466,0.12379484528368,14.9005952380952,0,"Nedd4l"]
["cellular respiration","GO:0045333",1,70,25,25033,0.0676427978447718,0.127030881376283,14.3045714285714,0,"Nfatc3"]
["nerve development","GO:0021675",1,70,25,25033,0.0676427978447718,0.127030881376283,14.3045714285714,0,"Sema3f"]
["head development","GO:0060322",1,70,25,25033,0.0676427978447718,0.127030881376283,14.3045714285714,0,"Ankrd11"]
["positive regulation of sodium ion transport","GO:0010765",1,70,25,25033,0.0676427978447718,0.127030881376283,14.3045714285714,0,"Nedd4l"]
["regulation of dendrite morphogenesis","GO:0048814",1,70,26,25033,0.0702525628859933,0.129733066129468,13.7543956043956,0,"Nedd4l"]
["sulfation","GO:0051923",1,70,26,25033,0.0702525628859933,0.129733066129468,13.7543956043956,0,"Chsy1"]
["natural killer cell differentiation","GO:0001779",1,70,26,25033,0.0702525628859933,0.129733066129468,13.7543956043956,0,"Tox"]
["regulation of potassium ion transmembrane transport","GO:1901379",1,70,26,25033,0.0702525628859933,0.129733066129468,13.7543956043956,0,"Kcne1"]
["intra-Golgi vesicle-mediated transport","GO:0006891",1,70,26,25033,0.0702525628859933,0.129733066129468,13.7543956043956,0,"Vti1a"]
["actin filament organization","GO:0007015",2,70,156,25033,0.0707957096970162,0.130301738113445,4.58479853479853,0,"Myo6, Clrn1"]
["gastrulation with mouth forming second","GO:0001702",1,70,27,25033,0.0728551269919628,0.132768882741932,13.2449735449735,0,"Acvr2a"]
["nitrogen compound transport","GO:0071705",1,70,27,25033,0.0728551269919628,0.132768882741932,13.2449735449735,0,"Myo6"]
["mesoderm development","GO:0007498",1,70,27,25033,0.0728551269919628,0.132768882741932,13.2449735449735,0,"Acvr2a"]
["proximal/distal pattern formation","GO:0009954",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Chsy1"]
["nervous system process","GO:0050877",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Rest"]
["neuronal stem cell population maintenance","GO:0097150",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Rest"]
["positive regulation of cardiac muscle hypertrophy","GO:0010613",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Nfatc3"]
["positive regulation of erythrocyte differentiation","GO:0045648",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Acvr2a"]
["negative regulation of non-canonical NF-kappaB signal transduction","GO:1901223",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Ppm1a"]
["brain morphogenesis","GO:0048854",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Slc4a10"]
["Golgi to plasma membrane transport","GO:0006893",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Gga1"]
["cochlea morphogenesis","GO:0090103",1,70,28,25033,0.0754505097445247,0.133544991688392,12.7719387755102,0,"Myo3a"]
["protein polyubiquitination","GO:0000209",2,70,163,25033,0.0763695787850224,0.134741231359562,4.38790534618756,0,"Ube2g1, Ube2b"]
["regulation of intracellular pH","GO:0051453",1,70,29,25033,0.0780387306730544,0.135104552477725,12.3315270935961,0,"Slc4a10"]
["positive regulation of neural precursor cell proliferation","GO:2000179",1,70,29,25033,0.0780387306730544,0.135104552477725,12.3315270935961,0,"Tox"]
["positive regulation of dendrite extension","GO:1903861",1,70,29,25033,0.0780387306730544,0.135104552477725,12.3315270935961,0,"Nedd4l"]
["regulation of cell size","GO:0008361",1,70,29,25033,0.0780387306730544,0.135104552477725,12.3315270935961,0,"Wdtc1"]
["negative regulation of interleukin-2 production","GO:0032703",1,70,29,25033,0.0780387306730544,0.135104552477725,12.3315270935961,0,"Homer2"]
["non-canonical Wnt signaling pathway","GO:0035567",1,70,29,25033,0.0780387306730544,0.135104552477725,12.3315270935961,0,"Ccdc88c"]
["positive regulation of lamellipodium assembly","GO:0010592",1,70,30,25033,0.0806198092545967,0.138706131450455,11.9204761904762,0,"Clrn1"]
["regulation of pH","GO:0006885",1,70,30,25033,0.0806198092545967,0.138706131450455,11.9204761904762,0,"Slc4a10"]
["proteasomal protein catabolic process","GO:0010498",1,70,31,25033,0.0831937649140047,0.139664684128359,11.5359447004608,0,"Ankrd11"]
["negative regulation of ossification","GO:0030279",1,70,31,25033,0.0831937649140047,0.139664684128359,11.5359447004608,0,"Chsy1"]
["monoatomic ion transmembrane transport","GO:0034220",3,70,364,25033,0.0820004358929954,0.139664684128359,2.9473704866562,0,"Slc4a10, Kcne1, Slc17a8"]
["membrane organization","GO:0061024",1,70,31,25033,0.0831937649140047,0.139664684128359,11.5359447004608,0,"Baiap2l2"]
["cellular response to glucocorticoid stimulus","GO:0071385",1,70,31,25033,0.0831937649140047,0.139664684128359,11.5359447004608,0,"Rest"]
["sterol biosynthetic process","GO:0016126",1,70,31,25033,0.0831937649140047,0.139664684128359,11.5359447004608,0,"Cyb5r2"]
["estrogen metabolic process","GO:0008210",1,70,31,25033,0.0831937649140047,0.139664684128359,11.5359447004608,0,"Hsd17b4"]
["Golgi to plasma membrane protein transport","GO:0043001",1,70,31,25033,0.0831937649140047,0.139664684128359,11.5359447004608,0,"Gga1"]
["homophilic cell adhesion via plasma membrane adhesion molecules","GO:0007156",2,70,172,25033,0.0837332509704515,0.140145682893142,4.15830564784053,0,"Nptn, Emb"]
["cell-cell junction organization","GO:0045216",1,70,32,25033,0.0857606170240767,0.140983328876375,11.1754464285714,0,"Marveld2"]
["long-chain fatty acid metabolic process","GO:0001676",1,70,32,25033,0.0857606170240767,0.140983328876375,11.1754464285714,0,"Acsl4"]
["cellular response to stress","GO:0033554",1,70,32,25033,0.0857606170240767,0.140983328876375,11.1754464285714,0,"Rest"]
["SMAD protein signal transduction","GO:0060395",1,70,32,25033,0.0857606170240767,0.140983328876375,11.1754464285714,0,"Acvr2a"]
["positive regulation of long-term synaptic potentiation","GO:1900273",1,70,32,25033,0.0857606170240767,0.140983328876375,11.1754464285714,0,"Nptn"]
["response to light stimulus","GO:0009416",1,70,32,25033,0.0857606170240767,0.140983328876375,11.1754464285714,0,"Slc4a10"]
["positive regulation of cytosolic calcium ion concentration","GO:0007204",2,70,175,25033,0.0862347448492097,0.141343339190716,4.08702040816327,0,"Nptn, Cib2"]
["cellular response to BMP stimulus","GO:0071773",1,70,33,25033,0.088320384905694,0.143488249964089,10.8367965367965,0,"Acvr2a"]
["positive regulation of calcium ion transport","GO:0051928",1,70,33,25033,0.088320384905694,0.143488249964089,10.8367965367965,0,"Atp2b1"]
["lysosome localization","GO:0032418",1,70,33,25033,0.088320384905694,0.143488249964089,10.8367965367965,0,"Klc2"]
["extracellular matrix organization","GO:0030198",2,70,178,25033,0.0887587899817699,0.14377885862544,4.01813804173355,0,"Col9a2, Col9a3"]
["protein glycosylation","GO:0006486",2,70,179,25033,0.0896050563440701,0.144726534153396,3.99569034317638,0,"Tmtc4, Slc4a10"]
["lipid biosynthetic process","GO:0008610",1,70,34,25033,0.090873087827958,0.145197254301162,10.5180672268908,0,"Acsl4"]
["negative regulation of neurogenesis","GO:0050768",1,70,34,25033,0.090873087827958,0.145197254301162,10.5180672268908,0,"Rest"]
["female gonad development","GO:0008585",1,70,34,25033,0.090873087827958,0.145197254301162,10.5180672268908,0,"Col9a3"]
["monoatomic ion transport","GO:0006811",4,70,609,25033,0.0909448506182366,0.145197254301162,2.34886230354211,0,"Slc4a10, Kcne1, Slc17a8, Atp2b1"]
["fatty acid transport","GO:0015908",1,70,35,25033,0.093418745008327,0.146611854772275,10.2175510204082,0,"Acsl4"]
["skeletal muscle fiber development","GO:0048741",1,70,35,25033,0.093418745008327,0.146611854772275,10.2175510204082,0,"Nfatc3"]
["cell adhesion","GO:0007155",4,70,612,25033,0.0921944389549336,0.146611854772275,2.33734827264239,0,"Mpdz, Nptn, Emb, Mpzl2"]
["transmission of nerve impulse","GO:0019226",1,70,35,25033,0.093418745008327,0.146611854772275,10.2175510204082,0,"Otoa"]
["sperm axoneme assembly","GO:0007288",1,70,35,25033,0.093418745008327,0.146611854772275,10.2175510204082,0,"Ube2b"]
["tissue homeostasis","GO:0001894",1,70,35,25033,0.093418745008327,0.146611854772275,10.2175510204082,0,"Ankrd11"]
["positive regulation of neuron projection development","GO:0010976",2,70,186,25033,0.0955957497408481,0.149604647899519,3.84531490015361,0,"Nptn, Tox"]
["B cell homeostasis","GO:0001782",1,70,36,25033,0.095957375612752,0.149747566449196,9.93373015873016,0,"Spns2"]
["protein K11-linked ubiquitination","GO:0070979",1,70,37,25033,0.0984889987558136,0.15198580866496,9.66525096525097,0,"Ube2b"]
["microtubule bundle formation","GO:0001578",1,70,37,25033,0.0984889987558136,0.15198580866496,9.66525096525097,0,"Ccdc88c"]
["protein export from nucleus","GO:0006611",1,70,37,25033,0.0984889987558136,0.15198580866496,9.66525096525097,0,"Ppm1a"]
["protein localization to cell surface","GO:0034394",1,70,37,25033,0.0984889987558136,0.15198580866496,9.66525096525097,0,"Gga1"]
["axon guidance","GO:0007411",2,70,191,25033,0.0999439029397872,0.153802561746228,3.74465220643231,0,"Sema3f, Emb"]
["negative regulation of microtubule depolymerization","GO:0007026",1,70,38,25033,0.101013633500857,0.155018152242312,9.4109022556391,0,"Ccdc88c"]
["monoatomic anion transmembrane transport","GO:0098656",1,70,39,25033,0.103531298860126,0.15757236145195,9.16959706959707,0,"Slc4a10"]
["regulation of heart rate by cardiac conduction","GO:0086091",1,70,39,25033,0.103531298860126,0.15757236145195,9.16959706959707,0,"Kcne1"]
["cilium organization","GO:0044782",1,70,39,25033,0.103531298860126,0.15757236145195,9.16959706959707,0,"Ccdc88c"]
["bone morphogenesis","GO:0060349",1,70,40,25033,0.106042013794902,0.159639335984716,8.94035714285714,0,"Chsy1"]
["blastocyst hatching","GO:0001835",1,70,40,25033,0.106042013794902,0.159639335984716,8.94035714285714,0,"Phf6"]
["positive regulation of filopodium assembly","GO:0051491",1,70,40,25033,0.106042013794902,0.159639335984716,8.94035714285714,0,"Myo3a"]
["regulation of postsynaptic neurotransmitter receptor internalization","GO:0099149",1,70,40,25033,0.106042013794902,0.159639335984716,8.94035714285714,0,"Nedd4l"]
["T cell homeostasis","GO:0043029",1,70,41,25033,0.108545797215634,0.160358324419897,8.72229965156794,0,"Spns2"]
["system development","GO:0048731",1,70,41,25033,0.108545797215634,0.160358324419897,8.72229965156794,0,"Sema3f"]
["branching involved in blood vessel morphogenesis","GO:0001569",1,70,41,25033,0.108545797215634,0.160358324419897,8.72229965156794,0,"Nfatc3"]
["cell motility","GO:0048870",1,70,41,25033,0.108545797215634,0.160358324419897,8.72229965156794,0,"Clrn1"]
["positive regulation of axonogenesis","GO:0050772",1,70,41,25033,0.108545797215634,0.160358324419897,8.72229965156794,0,"Nin"]
["positive regulation of SMAD protein signal transduction","GO:0060391",1,70,41,25033,0.108545797215634,0.160358324419897,8.72229965156794,0,"Acvr2a"]
["negative chemotaxis","GO:0050919",1,70,41,25033,0.108545797215634,0.160358324419897,8.72229965156794,0,"Sema3f"]
["G2/M transition of mitotic cell cycle","GO:0000086",1,70,42,25033,0.111042667982075,0.16274507423828,8.51462585034014,0,"Ush1c"]
["face morphogenesis","GO:0060325",1,70,42,25033,0.111042667982075,0.16274507423828,8.51462585034014,0,"Ankrd11"]
["positive regulation of substrate adhesion-dependent cell spreading","GO:1900026",1,70,42,25033,0.111042667982075,0.16274507423828,8.51462585034014,0,"Triobp"]
["fatty acid metabolic process","GO:0006631",2,70,204,25033,0.111500213876878,0.162984481498128,3.50602240896359,0,"Acsl4, Hsd17b4"]
["semaphorin-plexin signaling pathway","GO:0071526",1,70,43,25033,0.113532644903417,0.165084213324129,8.31661129568106,0,"Sema3f"]
["macroautophagy","GO:0016236",1,70,43,25033,0.113532644903417,0.165084213324129,8.31661129568106,0,"Vti1a"]
["DNA metabolic process","GO:0006259",1,70,44,25033,0.116015746738422,0.168253203385041,8.1275974025974,0,"Dnase1"]
["response to hypoxia","GO:0001666",2,70,212,25033,0.118778896312957,0.17047541077041,3.37371967654987,0,"Rest, Nfatc3"]
["positive regulation of smoothened signaling pathway","GO:0045880",1,70,45,25033,0.118491992195555,0.17047541077041,7.94698412698413,0,"Chsy1"]
["negative regulation of insulin secretion","GO:0046676",1,70,45,25033,0.118491992195555,0.17047541077041,7.94698412698413,0,"Rest"]
["protein targeting","GO:0006605",1,70,45,25033,0.118491992195555,0.17047541077041,7.94698412698413,0,"Myo6"]
["neural precursor cell proliferation","GO:0061351",1,70,46,25033,0.120961399933122,0.172268934609125,7.77422360248447,0,"Ankrd11"]
["positive regulation of Notch signaling pathway","GO:0045747",1,70,46,25033,0.120961399933122,0.172268934609125,7.77422360248447,0,"Aak1"]
["regulation of G protein-coupled receptor signaling pathway","GO:0008277",1,70,46,25033,0.120961399933122,0.172268934609125,7.77422360248447,0,"Homer2"]
["calcium ion homeostasis","GO:0055074",1,70,47,25033,0.123423988559395,0.174430840974247,7.60881458966565,0,"Cib2"]
["protein stabilization","GO:0050821",2,70,217,25033,0.12338780557012,0.174430840974247,3.29598420013167,0,"Ube2b, Aak1"]
["T cell differentiation in thymus","GO:0033077",1,70,47,25033,0.123423988559395,0.174430840974247,7.60881458966565,0,"Mpzl2"]
["cytoplasmic microtubule organization","GO:0031122",1,70,48,25033,0.12587977663275,0.176550370264666,7.45029761904762,0,"Ccdc88c"]
["positive regulation of stem cell population maintenance","GO:1902459",1,70,48,25033,0.12587977663275,0.176550370264666,7.45029761904762,0,"Rest"]
["positive regulation of cysteine-type endopeptidase activity involved in apoptotic process","GO:0043280",1,70,48,25033,0.12587977663275,0.176550370264666,7.45029761904762,0,"Rest"]
["neurotransmitter transport","GO:0006836",1,70,49,25033,0.128328782661795,0.178628506519182,7.29825072886297,0,"Slc17a8"]
["neural crest cell migration","GO:0001755",1,70,49,25033,0.128328782661795,0.178628506519182,7.29825072886297,0,"Sema3f"]
["regulation of cytosolic calcium ion concentration","GO:0051480",1,70,49,25033,0.128328782661795,0.178628506519182,7.29825072886297,0,"Atp2b1"]
["autophagy","GO:0006914",2,70,225,25033,0.13085151712784,0.179435001209959,3.17879365079365,0,"Vti1a, Acvr2a"]
["RNA polymerase II preinitiation complex assembly","GO:0051123",1,70,50,25033,0.130771025105506,0.179435001209959,7.15228571428572,0,"Med28"]
["cytokine production","GO:0001816",1,70,50,25033,0.130771025105506,0.179435001209959,7.15228571428572,0,"Nfatc3"]
["cell communication","GO:0007154",1,70,50,25033,0.130771025105506,0.179435001209959,7.15228571428572,0,"Gjb3"]
["endoplasmic reticulum unfolded protein response","GO:0030968",1,70,50,25033,0.130771025105506,0.179435001209959,7.15228571428572,0,"Tmtc4"]
["nervous system development","GO:0007399",3,70,447,25033,0.129753084073365,0.179435001209959,2.40009587727709,0,"Nr2f1, Nptn, Tox"]
["protein monoubiquitination","GO:0006513",1,70,51,25033,0.133206522373353,0.180431328593735,7.01204481792717,0,"Nedd4l"]
["mitotic spindle organization","GO:0007052",1,70,51,25033,0.133206522373353,0.180431328593735,7.01204481792717,0,"Nin"]
["blood vessel remodeling","GO:0001974",1,70,51,25033,0.133206522373353,0.180431328593735,7.01204481792717,0,"Nfatc3"]
["sphingolipid metabolic process","GO:0006665",1,70,51,25033,0.133206522373353,0.180431328593735,7.01204481792717,0,"Spns2"]
["positive regulation of nitric oxide biosynthetic process","GO:0045429",1,70,51,25033,0.133206522373353,0.180431328593735,7.01204481792717,0,"Nfatc3"]
["regulation of postsynapse organization","GO:0099175",1,70,53,25033,0.138057354772602,0.186091908866232,6.74743935309973,0,"Sema3f"]
["positive regulation of transcription elongation by RNA polymerase II","GO:0032968",1,70,53,25033,0.138057354772602,0.186091908866232,6.74743935309973,0,"Med28"]
["embryonic skeletal system development","GO:0048706",1,70,54,25033,0.140472726476602,0.188888083660285,6.62248677248677,0,"Acvr2a"]
["response to UV","GO:0009411",1,70,55,25033,0.142881426150193,0.190279591555786,6.50207792207792,0,"Ube2b"]
["ubiquitin-dependent protein catabolic process","GO:0006511",2,70,237,25033,0.142237351752254,0.190279591555786,3.01784207353828,0,"Ube2b, Nedd4l"]
["synaptic transmission, glutamatergic","GO:0035249",1,70,55,25033,0.142881426150193,0.190279591555786,6.50207792207792,0,"Slc17a8"]
["skeletal system morphogenesis","GO:0048705",1,70,55,25033,0.142881426150193,0.190279591555786,6.50207792207792,0,"Ankrd11"]
["placenta development","GO:0001890",1,70,57,25033,0.147678882013054,0.195727513481415,6.27393483709273,0,"Gjb3"]
["cellular response to cAMP","GO:0071320",1,70,57,25033,0.147678882013054,0.195727513481415,6.27393483709273,0,"Kcne1"]
["positive regulation of actin filament polymerization","GO:0030838",1,70,58,25033,0.150067674384093,0.197946408592351,6.16576354679803,0,"Baiap2l2"]
["presynaptic modulation of chemical synaptic transmission","GO:0099171",1,70,58,25033,0.150067674384093,0.197946408592351,6.16576354679803,0,"Myo6"]
["negative regulation of BMP signaling pathway","GO:0030514",1,70,59,25033,0.152449867088522,0.198256399922632,6.06125907990315,0,"Ppm1a"]
["regulation of signal transduction","GO:0009966",1,70,59,25033,0.152449867088522,0.198256399922632,6.06125907990315,0,"Acvr2a"]
["protein destabilization","GO:0031648",1,70,59,25033,0.152449867088522,0.198256399922632,6.06125907990315,0,"Ccdc88c"]
["establishment of protein localization","GO:0045184",1,70,59,25033,0.152449867088522,0.198256399922632,6.06125907990315,0,"Myo6"]
["fatty acid beta-oxidation","GO:0006635",1,70,59,25033,0.152449867088522,0.198256399922632,6.06125907990315,0,"Hsd17b4"]
["anatomical structure development","GO:0048856",1,70,59,25033,0.152449867088522,0.198256399922632,6.06125907990315,0,"Nr2f1"]
["positive regulation of miRNA transcription","GO:1902895",1,70,60,25033,0.154825478096122,0.199472825268027,5.9602380952381,0,"Nr2f1"]
["thymus development","GO:0048538",1,70,60,25033,0.154825478096122,0.199472825268027,5.9602380952381,0,"Nfatc3"]
["synaptic vesicle endocytosis","GO:0048488",1,70,60,25033,0.154825478096122,0.199472825268027,5.9602380952381,0,"Ap3m2"]
["T cell differentiation","GO:0030217",1,70,60,25033,0.154825478096122,0.199472825268027,5.9602380952381,0,"Nfatc3"]
["synapse assembly","GO:0007416",1,70,61,25033,0.157194525328464,0.202055143925682,5.86252927400468,0,"Myo6"]
["regulation of alternative mRNA splicing, via spliceosome","GO:0000381",1,70,62,25033,0.159557026659034,0.203205960388747,5.76797235023041,0,"Rest"]
["endocytic recycling","GO:0032456",1,70,62,25033,0.159557026659034,0.203205960388747,5.76797235023041,0,"Vti1a"]
["positive regulation of protein phosphorylation","GO:0001934",2,70,254,25033,0.158711308017291,0.203205960388747,2.81586051743532,0,"Nptn, Acvr2a"]
["peptidyl-threonine phosphorylation","GO:0018107",1,70,62,25033,0.159557026659034,0.203205960388747,5.76797235023041,0,"Myo3a"]
["proteolysis involved in protein catabolic process","GO:0051603",1,70,63,25033,0.161912999913364,0.20479406838357,5.67641723356009,0,"Clpp"]
["positive regulation of transcription initiation by RNA polymerase II","GO:0060261",1,70,63,25033,0.161912999913364,0.20479406838357,5.67641723356009,0,"Med28"]
["cognition","GO:0050890",1,70,63,25033,0.161912999913364,0.20479406838357,5.67641723356009,0,"Ankrd11"]
["cilium movement","GO:0003341",1,70,64,25033,0.164262462869154,0.206821373703434,5.58772321428571,0,"Ccdc88c"]
["negative regulation of canonical NF-kappaB signal transduction","GO:0043124",1,70,64,25033,0.164262462869154,0.206821373703434,5.58772321428571,0,"Ppm1a"]
["skin development","GO:0043588",1,70,65,25033,0.1666054332564,0.20929571434024,5.50175824175824,0,"Gjb3"]
["response to ischemia","GO:0002931",1,70,68,25033,0.173595565593949,0.217092422887241,5.25903361344538,0,"Rest"]
["bicellular tight junction assembly","GO:0070830",1,70,68,25033,0.173595565593949,0.217092422887241,5.25903361344538,0,"Marveld2"]
["cellular response to retinoic acid","GO:0071300",1,70,69,25033,0.175912742057335,0.21949472770217,5.18281573498965,0,"Gjb3"]
["social behavior","GO:0035176",1,70,70,25033,0.178223513891015,0.221878262237353,5.10877551020408,0,"Ankrd11"]
["steroid biosynthetic process","GO:0006694",1,70,71,25033,0.180527898541403,0.224243174421384,5.03682092555332,0,"Cyb5r2"]
["regulation of protein phosphorylation","GO:0001932",1,70,72,25033,0.182825913408084,0.225580302957859,4.96686507936508,0,"Ccdc88c"]
["regulation of synaptic plasticity","GO:0048167",1,70,72,25033,0.182825913408084,0.225580302957859,4.96686507936508,0,"Myo6"]
["adult locomotory behavior","GO:0008344",1,70,72,25033,0.182825913408084,0.225580302957859,4.96686507936508,0,"Otog"]
["protein autoubiquitination","GO:0051865",1,70,73,25033,0.185117575843941,0.22739498230054,4.89882583170254,0,"Ube2b"]
["embryo development","GO:0009790",1,70,73,25033,0.185117575843941,0.22739498230054,4.89882583170254,0,"Ankrd11"]
["positive regulation of insulin secretion","GO:0032024",1,70,75,25033,0.189681912601934,0.232486238012105,4.76819047619048,0,"Acsl4"]
["visual learning","GO:0008542",1,70,79,25033,0.198735115319562,0.242509369795236,4.52676311030742,0,"Nptn"]
["positive regulation of osteoblast differentiation","GO:0045669",1,70,79,25033,0.198735115319562,0.242509369795236,4.52676311030742,0,"Acvr2a"]
["negative regulation of neuron differentiation","GO:0045665",1,70,80,25033,0.200982792723089,0.244713114656245,4.47017857142857,0,"Rest"]
["spermatogenesis","GO:0007283",3,70,554,25033,0.202112545878244,0.245549014071375,1.93653945332646,0,"Gjb3, Ube2b, Acvr2a"]
["synapse organization","GO:0050808",1,70,81,25033,0.203224254852268,0.246359381155703,4.41499118165785,0,"Nptn"]
["cellular response to growth factor stimulus","GO:0071363",1,70,82,25033,0.205459518645164,0.248525269278211,4.36114982578397,0,"Acvr2a"]
["cellular response to transforming growth factor beta stimulus","GO:0071560",1,70,83,25033,0.207688600994362,0.250674259152236,4.30860585197935,0,"Ppm1a"]
["roof of mouth development","GO:0060021",1,70,84,25033,0.209911518747083,0.25280648127366,4.25731292517007,0,"Ankrd11"]
["microtubule-based movement","GO:0007018",1,70,85,25033,0.212128288705306,0.254922064951712,4.2072268907563,0,"Klc2"]
["determination of left/right symmetry","GO:0007368",1,70,87,25033,0.216543452220674,0.259664659156393,4.11050903119869,0,"Acvr2a"]
["cellular response to xenobiotic stimulus","GO:0071466",1,70,88,25033,0.218741879156638,0.261734343526517,4.0637987012987,0,"Rest"]
["transmembrane transport","GO:0055085",3,70,580,25033,0.220985332871381,0.262716468692586,1.84972906403941,0,"Slc4a10, Slc17a8, Spns2"]
["chloride transport","GO:0006821",1,70,89,25033,0.220934225055978,0.262716468692586,4.01813804173355,0,"Slc17a8"]
["cell-cell signaling","GO:0007267",1,70,89,25033,0.220934225055978,0.262716468692586,4.01813804173355,0,"Gjb3"]
["cellular response to calcium ion","GO:0071277",1,70,90,25033,0.223120506496248,0.264121283331028,3.97349206349206,0,"Nfatc3"]
["negative regulation of neuron projection development","GO:0010977",1,70,90,25033,0.223120506496248,0.264121283331028,3.97349206349206,0,"Nr2f1"]
["response to xenobiotic stimulus","GO:0009410",2,70,321,25033,0.226337320397573,0.267357943497346,2.22812639074321,0,"Ube2b, Myo6"]
["myelination","GO:0042552",1,70,92,25033,0.227474942087259,0.268130038119876,3.88711180124224,0,"Mpdz"]
["regulation of protein stability","GO:0031647",1,70,95,25033,0.233961523915438,0.274607381883798,3.76436090225564,0,"Nedd4l"]
["negative regulation of transforming growth factor beta receptor signaling pathway","GO:0030512",1,70,95,25033,0.233961523915438,0.274607381883798,3.76436090225564,0,"Ppm1a"]
["response to nutrient levels","GO:0031667",1,70,96,25033,0.236111764244491,0.276545279897353,3.72514880952381,0,"Chsy1"]
["BMP signaling pathway","GO:0030509",1,70,97,25033,0.238256054917101,0.278468047308173,3.68674521354934,0,"Acvr2a"]
["cell-matrix adhesion","GO:0007160",1,70,98,25033,0.24039441215787,0.280375798600968,3.64912536443149,0,"Otoa"]
["forebrain development","GO:0030900",1,70,99,25033,0.242526852147802,0.282268647247651,3.61226551226551,0,"Nr2f1"]
["cartilage development","GO:0051216",1,70,100,25033,0.244653391024422,0.28355225654295,3.57614285714286,0,"Chsy1"]
["positive regulation of cell growth","GO:0030307",1,70,100,25033,0.244653391024422,0.28355225654295,3.57614285714286,0,"Acsl4"]
["small GTPase-mediated signal transduction","GO:0007264",1,70,106,25033,0.257289599156502,0.297575026999378,3.37371967654987,0,"Ccdc88c"]
["cellular response to insulin stimulus","GO:0032869",1,70,108,25033,0.261455184203736,0.301762858435145,3.31124338624339,0,"Wdtc1"]
["DNA-templated transcription","GO:0006351",1,70,109,25033,0.26352933213175,0.302894709545621,3.28086500655308,0,"Nfatc3"]
["regulation of membrane potential","GO:0042391",1,70,109,25033,0.26352933213175,0.302894709545621,3.28086500655308,0,"Nedd4l"]
["neurogenesis","GO:0022008",1,70,110,25033,0.265597737955485,0.304640055543144,3.25103896103896,0,"Ankrd11"]
["protein phosphorylation","GO:0006468",3,70,641,25033,0.266523341459115,0.305070105719731,1.67370180521507,0,"Aak1, Myo3a, Acvr2a"]
["hematopoietic progenitor cell differentiation","GO:0002244",1,70,111,25033,0.267660417341719,0.305110846105581,3.22175032175032,0,"Rest"]
["chloride transmembrane transport","GO:1902476",1,70,111,25033,0.267660417341719,0.305110846105581,3.22175032175032,0,"Slc17a8"]
["response to wounding","GO:0009611",1,70,113,25033,0.271768659258314,0.30852425661702,3.16472819216182,0,"Ocm"]
["post-embryonic development","GO:0009791",1,70,113,25033,0.271768659258314,0.30852425661702,3.16472819216182,0,"Slc4a10"]
["positive regulation of JNK cascade","GO:0046330",1,70,114,25033,0.273814252912082,0.310210830497533,3.13696741854637,0,"Ccdc88c"]
["dephosphorylation","GO:0016311",1,70,115,25033,0.27585418237539,0.310616294788548,3.10968944099379,0,"Ppm1a"]
["positive regulation of transcription by RNA polymerase II","GO:0045944",5,70,1258,25033,0.275336691863524,0.310616294788548,1.42136043606632,0,"Rest, Nr2f1, Tox, Nfatc3, Acvr2a"]
["calcium-mediated signaling","GO:0019722",1,70,115,25033,0.27585418237539,0.310616294788548,3.10968944099379,0,"Homer2"]
["endoplasmic reticulum to Golgi vesicle-mediated transport","GO:0006888",1,70,116,25033,0.277888463105533,0.312272228317374,3.08288177339901,0,"Vti1a"]
["apoptotic process","GO:0006915",3,70,660,25033,0.280963325231554,0.314908946679938,1.62551948051948,0,"Ube2b, Nisch, Dnase1"]
["regulation of protein localization","GO:0032880",1,70,118,25033,0.281940139987815,0.314908946679938,3.03062953995157,0,"Aak1"]
["protein import into nucleus","GO:0006606",1,70,118,25033,0.281940139987815,0.314908946679938,3.03062953995157,0,"Nfatc3"]
["phosphorylation","GO:0016310",3,70,673,25033,0.290889560845851,0.324251140258755,1.59412014434303,0,"Aak1, Myo3a, Acvr2a"]
["locomotory behavior","GO:0007626",1,70,125,25033,0.295945326651614,0.329224319206816,2.86091428571429,0,"Myo6"]
["positive regulation of apoptotic process","GO:0043065",2,70,389,25033,0.296771238099986,0.329481494804394,1.83863385971355,0,"Rest, Nfatc3"]
["proton transmembrane transport","GO:1902600",1,70,128,25033,0.30186480073192,0.333798602006953,2.79386160714286,0,"Slc4a10"]
["anterior/posterior pattern specification","GO:0009952",1,70,128,25033,0.30186480073192,0.333798602006953,2.79386160714286,0,"Acvr2a"]
["protein-containing complex assembly","GO:0065003",1,70,129,25033,0.303827035783065,0.33529915901159,2.77220376522702,0,"Ush1c"]
["cell division","GO:0051301",2,70,402,25033,0.310207567034754,0.341660024129729,1.77917555081734,0,"Klhl18, Triobp"]
["calcium ion transmembrane transport","GO:0070588",1,70,133,25033,0.311621757786197,0.342536614709431,2.68882921589689,0,"Atp2b1"]
["negative regulation of canonical Wnt signaling pathway","GO:0090090",1,70,138,25033,0.32124427526954,0.352414511879851,2.59140786749482,0,"Ccdc88c"]
["chromatin organization","GO:0006325",2,70,421,25033,0.329755702246699,0.361036875582354,1.69888021717,0,"Ube2b, Tox"]
["modulation of chemical synaptic transmission","GO:0050804",1,70,143,25033,0.330734179121923,0.36139395509575,2.5007992007992,0,"Nptn"]
["steroid metabolic process","GO:0008202",1,70,145,25033,0.334493413196024,0.364487611769066,2.46630541871921,0,"Cyb5r2"]
["regulation of DNA-templated transcription","GO:0006355",5,70,1366,25033,0.33488121731129,0.364487611769066,1.3089834762602,0,"Rest, Nr2f1, Zfp719, Ewsr1, Nfatc3"]
["neuron migration","GO:0001764",1,70,146,25033,0.336365217321558,0.365384961561065,2.44941291585127,0,"Nr2f1"]
["potassium ion transport","GO:0006813",1,70,148,25033,0.340093270843468,0.368711686980981,2.41631274131274,0,"Kcne1"]
["negative regulation of cell migration","GO:0030336",1,70,150,25033,0.343800679072204,0.372003078527346,2.38409523809524,0,"Nisch"]
["protein dephosphorylation","GO:0006470",1,70,154,25033,0.351154009772247,0.379218950124415,2.3221706864564,0,"Ppm1a"]
["regulation of gene expression","GO:0010468",2,70,446,25033,0.355252241424433,0.382898330251237,1.60365150544523,0,"Rest, Nr2f1"]
["calcium ion transport","GO:0006816",1,70,157,25033,0.35661564757611,0.383621492732359,2.27779799818016,0,"Atp2b1"]
["lipid metabolic process","GO:0006629",3,70,760,25033,0.357707739278834,0.38405055728774,1.41163533834586,0,"Acsl4, Hsd17b4, Cyb5r2"]
["potassium ion transmembrane transport","GO:0071805",1,70,158,25033,0.358426103624899,0.38407748821701,2.26338155515371,0,"Kcne1"]
["protein autophosphorylation","GO:0046777",1,70,159,25033,0.360231537705151,0.38526693414798,2.24914645103324,0,"Myo3a"]
["chemical synaptic transmission","GO:0007268",1,70,166,25033,0.372730109732206,0.397866051621661,2.15430292598967,0,"Myo6"]
["peptidyl-serine phosphorylation","GO:0018105",1,70,170,25033,0.379763762827797,0.404594470397307,2.10361344537815,0,"Myo3a"]
["positive regulation of DNA-templated transcription","GO:0045893",3,70,790,25033,0.380672959558901,0.404784682525203,1.35802893309222,0,"Rest, Ppm1a, Nfatc3"]
["ossification","GO:0001503",1,70,173,25033,0.384987929463678,0.408588722074478,2.06713459950454,0,"Ankrd11"]
["lipid transport","GO:0006869",1,70,184,25033,0.403774765933222,0.427707878254311,1.94355590062112,0,"Spns2"]
["long-term synaptic potentiation","GO:0060291",1,70,199,25033,0.428484437859144,0.453015989644973,1.79705671213209,0,"Nptn"]
["establishment of localization in cell","GO:0051649",1,70,217,25033,0.456806420723734,0.482039537297045,1.64799210006583,0,"Nedd4l"]
["cell-cell adhesion","GO:0098609",1,70,220,25033,0.461390308507248,0.485951009340333,1.62551948051948,0,"Mpzl2"]
["positive regulation of ERK1 and ERK2 cascade","GO:0070374",1,70,227,25033,0.471938286359657,0.496117287748102,1.57539332913782,0,"Nptn"]
["actin cytoskeleton organization","GO:0030036",1,70,233,25033,0.480817154090017,0.503799494061563,1.53482526057633,0,"Nisch"]
["chromatin remodeling","GO:0006338",2,70,576,25033,0.481064859853009,0.503799494061563,1.24171626984127,0,"Rest, Aak1"]
["cilium assembly","GO:0060271",1,70,234,25033,0.482282589542182,0.504121801144092,1.52826617826618,0,"Elmod1"]
["Wnt signaling pathway","GO:0016055",1,70,242,25033,0.493860222727962,0.514283013893405,1.47774498229044,0,"Ccdc88c"]
["transcription by RNA polymerase II","GO:0006366",1,70,242,25033,0.493860222727962,0.514283013893405,1.47774498229044,0,"Nfatc3"]
["neuron differentiation","GO:0030182",1,70,253,25033,0.509363761183066,0.529432502242811,1.41349520045172,0,"Acsl4"]
["positive regulation of cell migration","GO:0030335",1,70,269,25033,0.531082159925758,0.550972877525973,1.32942113648433,0,"Sema3f"]
["cell cycle","GO:0007049",2,70,636,25033,0.534051916599294,0.553018246347681,1.12457322551662,0,"Klhl18, Triobp"]
["cell differentiation","GO:0030154",3,70,1020,25033,0.547342483344751,0.56572338763618,1.05180672268908,0,"Nr2f1, Ush1c, Nedd4l"]
["heart development","GO:0007507",1,70,312,25033,0.584864667933475,0.603379936750735,1.14619963369963,0,"Nfatc3"]
["translation","GO:0006412",1,70,319,25033,0.593024561810116,0.610660980005213,1.12104791759964,0,"Hars2"]
["gene expression","GO:0010467",1,70,339,25033,0.615477403454455,0.632605717094189,1.05490939738727,0,"Ankrd11"]
["negative regulation of gene expression","GO:0010629",1,70,393,25033,0.670180151784705,0.687555192756901,0.909960014540167,0,"Rest"]
["negative regulation of cell population proliferation","GO:0008285",1,70,396,25033,0.672983251709209,0.689154753136603,0.903066378066378,0,"Rest"]
["DNA repair","GO:0006281",1,70,399,25033,0.675762865896977,0.69072440536333,0.896276405298962,0,"Ube2b"]
["innate immune response","GO:0045087",1,70,544,25033,0.7856427533084,0.801558168200467,0.657379201680672,0,"Ccdc92"]
["DNA damage response","GO:0006974",1,70,549,25033,0.788689158296449,0.803187120765133,0.651392141556076,0,"Ube2b"]
["regulation of transcription by RNA polymerase II","GO:0006357",3,70,1479,25033,0.790355837401304,0.803407585174903,0.725383946682121,0,"Tox, Ikzf5, Nfatc3"]
["immune system process","GO:0002376",1,70,556,25033,0.792882546616909,0.804499873307267,0.643191161356629,0,"Ccdc92"]
["positive regulation of gene expression","GO:0010628",1,70,596,25033,0.815317606395389,0.825751286915988,0.600023969319271,0,"Rest"]
["negative regulation of apoptotic process","GO:0043066",1,70,630,25033,0.832490763578731,0.841605625953681,0.567641723356009,0,"Ube2b"]
["proteolysis","GO:0006508",1,70,634,25033,0.834404627460131,0.842003941007127,0.564060387561965,0,"Clpp"]
["negative regulation of DNA-templated transcription","GO:0045892",1,70,661,25033,0.846771180841465,0.85292951670213,0.541020099416469,0,"Rest"]
["multicellular organism development","GO:0007275",1,70,1109,25033,0.958263430027137,0.963480835272294,0.322465541672034,0,"Nfatc3"]
["signal transduction","GO:0007165",1,70,1585,25033,0.989798456833974,0.993384683126851,0.225624155024786,0,"Gpr152"]
["G protein-coupled receptor signaling pathway","GO:0007186",1,70,1929,25033,0.996380117396508,0.998181889760697,0.185388432200252,0,"Gpr152"]
["biological_process","GO:0008150",3,70,6411,25033,0.999999692595611,0.999999692595611,0.167344073801725,0,"Zcchc14, Ccdc92, Otogl"]

{"sheet":"Supplementary Table S21.","index":21,"n_rows":197,"n_cols":11,"rows_kept":197}
["Supplementary Table S21.- Active biochemical pathways according to Gene Ontology - Cellular Component in Mus musculus."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["stereocilium","GO:0032420",9,67,61,24814,{"v":6.77074751013309e-14,"d":"6.77E-14"},{"v":1.31352501696582E-11,"d":"1.31E-11"},54.6430144360166,0,"Tprn, Grxcr1, Triobp, Ush1c, Cib2, Ocm, Clrn1, Homer2, Eps8l2"]
["stereocilium tip","GO:0032426",4,67,21,24814,{"v":2.80599529651772E-7,"d":"2.81E-07"},{"v":2.72181543762219e-05,"d":"2.72E-05"},70.544420753376,0,"Myo3a, Ush1c, Homer2, Eps8l2"]
["apical part of cell","GO:0045177",6,67,146,24814,{"v":2.77924839530036e-06,"d":"2.78E-06"},0.000134793547172067,15.2202003680229,0,"Mpdz, Atp2b1, Ush1c, Myo6, Homer2, Nin"]
["plasma membrane","GO:0005886",34,67,5991,24814,{"v":2.20792131427365e-06,"d":"2.21E-06"},0.000134793547172067,2.10184929134996,0,"Gjb3, Baiap2l2, Cabp2, Acsl4, Ube2b, Nisch, Eps8l1, Aak1, Slc4a10, Sema3f, Marveld2, Kcne1, Mpdz, Nptn, Emb, Slc17a8, Gpr152, Atp2b1, Spns2, Ush1c, Cib2, Ppm1a, Ewsr1, Otog, Mpzl2, Nedd4l, Otoa, Myo6, Clrn1, Homer2, Nin, Eps8l2, Klc2, Acvr2a"]
["microvillus","GO:0005902",5,67,94,24814,{"v":5.62027284078766e-06,"d":"5.62E-06"},2.18066586222561E-4,19.6999047316608,0,"Tprn, Grxcr1, Ush1c, Myo6, Clrn1"]
["cuticular plate","GO:0032437",3,67,16,24814,{"v":1.02743779883323E-5,"d":"1.03E-05"},0.00033220488828941,69.4421641791045,0,"Triobp, Cib2, Ocm"]
["cytosol","GO:0005829",26,67,4179,24814,{"v":1.4986698225043e-05,"d":"1.50E-05"},0.000415345636522621,2.30421474822585,0,"Tprn, Rest, Baiap2l2, Nr2f1, Nisch, Eps8l1, Grxcr1, Aak1, Ankrd11, Hars2, Myo3a, Gga1, Vti1a, Triobp, Ush1c, Cib2, Ppm1a, Otog, Wdtc1, Ccdc88c, Myo6, Homer2, Nin, Eps8l2, Nfatc3, Klc2"]
["collagen type IX trimer","GO:0005594",2,67,4,24814,{"v":4.29413595591002E-5,"d":"4.29E-05"},0.00092562486160727,185.179104477612,0,"Col9a2, Col9a3"]
["cell projection","GO:0042995",13,67,1305,24814,{"v":3.95134582716704e-05,"d":"3.95E-05"},0.00092562486160727,3.68939211986047,0,"Tprn, Grxcr1, Aak1, Slc4a10, Mpdz, Myo3a, Atp2b1, Triobp, Ush1c, Cib2, Myo6, Homer2, Eps8l2"]
["synapse","GO:0045202",11,67,1032,24814,{"v":9.26754408075838e-05,"d":"9.27E-05"},1.7176050641833E-3,3.94761656832119,0,"Aak1, Slc4a10, Mpdz, Nptn, Emb, Slc17a8, Atp2b1, Ush1c, Myo6, Homer2, Elmod1"]
["glutamatergic synapse","GO:0098978",10,67,859,24814,{"v":9.73899778660634e-05,"d":"9.74E-05"},1.7176050641833E-3,4.31150417875697,0,"Ap3m2, Sema3f, Mpdz, Nptn, Slc17a8, Atp2b1, Nedd4l, Myo6, Homer2, Elmod1"]
["stereocilium base","GO:0120044",2,67,8,24814,0.0001989976748892,0.00296965760988498,92.589552238806,0,"Tprn, Triobp"]
["clathrin complex","GO:0071439",2,67,8,24814,0.0001989976748892,0.00296965760988498,92.589552238806,0,"Baiap2l2, Aak1"]
["apical plasma membrane","GO:0016324",7,67,480,24814,3.09950794825374E-4,0.00412189127615522,5.40105721393035,0,"Slc4a10, Marveld2, Kcne1, Mpdz, Atp2b1, Otog, Otoa"]
["basal dendrite","GO:0097441",2,67,10,24814,3.18702933723342E-4,0.00412189127615522,74.0716417910448,0,"Slc4a10, Slc17a8"]
["membrane","GO:0016020",37,67,8561,24814,0.000399348414898026,0.00484209953063856,1.60066040548339,0,"Chsy1, Gjb3, Tmtc4, Baiap2l2, Cabp2, Acsl4, Ap3m2, Ube2b, Nisch, Aak1, Slc4a10, Marveld2, Kcne1, Mpdz, Nptn, Emb, Slc17a8, Gpr152, Ap3s1, Atp2b1, Gga1, Vti1a, Spns2, Cib2, Med28, Ppm1a, Ewsr1, Otog, Mpzl2, Tram2, Otoa, Myo6, Clrn1, Homer2, Cyb5r2, Klc2, Acvr2a"]
["AP-3 adaptor complex","GO:0030123",2,67,13,24814,0.000549534033098469,0.0062711530835943,56.9781859931114,0,"Ap3m2, Ap3s1"]
["cytoplasmic vesicle","GO:0031410",9,67,899,24814,0.000671389101060435,0.00723608253365136,3.70770175817243,0,"Baiap2l2, Ap3m2, Marveld2, Mpdz, Slc17a8, Ap3s1, Atp2b1, Dnase1, Myo6"]
["Schmidt-Lanterman incisure","GO:0043220",2,67,17,24814,0.000951501566575626,0.00971533178503534,43.5715539947322,0,"Marveld2, Mpdz"]
["clathrin-coated vesicle","GO:0030136",3,67,80,24814,1.33241763744185E-3,0.0117495009847145,13.8884328358209,0,"Aak1, Vti1a, Myo6"]
["photoreceptor inner segment","GO:0001917",3,67,79,24814,1.28491895792025E-3,0.0117495009847145,14.0642357831098,0,"Myo3a, Ush1c, Cib2"]
["GABA-ergic synapse","GO:0098982",4,67,174,24814,0.00126908678804014,0.0117495009847145,8.51398181506262,0,"Ap3m2, Slc4a10, Nptn, Atp2b1"]
["synaptic vesicle","GO:0008021",4,67,186,24814,0.00162117892623272,0.0136742918125716,7.96469266570374,0,"Ap3m2, Slc17a8, Ap3s1, Vti1a"]
["ruffle membrane","GO:0032587",3,67,102,24814,0.00266938033673694,0.0214231569892164,10.8928884986831,0,"Eps8l1, Myo6, Eps8l2"]
["intracellular membrane-bounded organelle","GO:0043231",9,67,1103,24814,0.00276071610685778,0.0214231569892164,3.02196181377789,0,"Gjb3, Acsl4, Nisch, Aak1, Ap3s1, Atp2b1, Gga1, Vti1a, Ccdc92"]
["apical dendrite","GO:0097440",2,67,31,24814,0.00317496470254625,0.0236901212420758,23.8940779971112,0,"Slc4a10, Slc17a8"]
["cytoplasm","GO:0005737",31,67,7424,24814,0.00342234456641361,0.0245901794771941,1.54648497812661,0,"Tprn, Rest, Gjb3, Cabp2, Acsl4, Ube2b, Nisch, Eps8l1, Marveld2, Mpdz, Hars2, Myo3a, Vti1a, Triobp, Ush1c, Ccdc92, Cib2, Med28, Ppm1a, Ewsr1, Wdtc1, Ocm, Ccdc88c, Nedd4l, Myo6, Homer2, Nin, Eps8l2, Nfatc3, Klc2, Acvr2a"]
["ruffle","GO:0001726",3,67,113,24814,0.0035641368437624,0.0246943767032109,9.8325188218201,0,"Eps8l1, Myo6, Eps8l2"]
["protein-containing complex","GO:0032991",8,67,943,24814,0.00379158200582326,0.0253643761768866,3.14195723397857,0,"Rest, Eps8l1, Gga1, Ocm, Myo6, Ikzf5, Eps8l2, Klc2"]
["anchoring junction","GO:0070161",5,67,395,24814,0.00428986752433746,0.0277411433240489,4.68807859436992,0,"Gjb3, Baiap2l2, Marveld2, Mpdz, Ccdc88c"]
["vesicle membrane","GO:0012506",2,67,37,24814,0.00450020827324473,0.0281625937099832,20.0193626462283,0,"Baiap2l2, Myo6"]
["filamentous actin","GO:0031941",2,67,38,24814,0.00474197899522504,0.0287482476585518,19.4925373134328,0,"Myo3a, Myo6"]
["endopeptidase Clp complex","GO:0009368",1,67,2,24814,0.0053929953641698,0.0307717970779101,185.179104477612,0,"Clpp"]
["upper tip-link density","GO:1990435",1,67,2,24814,0.0053929953641698,0.0307717970779101,185.179104477612,0,"Ush1c"]
["cytoplasmic vesicle membrane","GO:0030659",3,67,141,24814,0.00659848711995051,0.0365744714648685,7.87996189266434,0,"Baiap2l2, Ap3m2, Ap3s1"]
["dendrite","GO:0030425",6,67,650,24814,0.00815113369845105,0.0376504747023691,3.41869115958668,0,"Slc4a10, Mpdz, Nptn, Slc17a8, Homer2, Nin"]
["immunological synapse","GO:0001772",2,67,49,24814,0.00778262952390698,0.0376504747023691,15.1166615900091,0,"Nptn, Atp2b1"]
["pericellular basket","GO:1990030",1,67,3,24814,0.0080787389281953,0.0376504747023691,123.452736318408,0,"Slc17a8"]
["inhibin-betaglycan-ActRII complex","GO:0034673",1,67,3,24814,0.0080787389281953,0.0376504747023691,123.452736318408,0,"Acvr2a"]
["glial limiting end-foot","GO:0097451",1,67,3,24814,0.0080787389281953,0.0376504747023691,123.452736318408,0,"Slc17a8"]
["CA3 pyramidal cell dendrite","GO:0097442",1,67,3,24814,0.0080787389281953,0.0376504747023691,123.452736318408,0,"Slc4a10"]
["stereocilium shaft","GO:0120043",1,67,3,24814,0.0080787389281953,0.0376504747023691,123.452736318408,0,"Triobp"]
["neuronal cell body","GO:0043025",6,67,658,24814,0.00862913020300904,0.0389314246368315,3.37712652542757,0,"Acsl4, Slc4a10, Slc17a8, Vti1a, Myo6, Homer2"]
["myosin complex","GO:0016459",2,67,53,24814,0.00905648830452284,0.0399308802517598,13.9757814700085,0,"Myo3a, Myo6"]
["synaptic vesicle membrane","GO:0030672",3,67,160,24814,0.00932219961319254,0.0401890383324301,6.94421641791045,0,"Slc17a8, Atp2b1, Vti1a"]
["HULC complex","GO:0033503",1,67,4,24814,0.0107573381177407,0.0435298072372986,92.589552238806,0,"Ube2b"]
["axon cytoplasm","GO:1904115",2,67,58,24814,0.0107702615844862,0.0435298072372986,12.7709727225939,0,"Ap3m2, Ap3s1"]
["tricellular tight junction","GO:0061689",1,67,4,24814,0.0107573381177407,0.0435298072372986,92.589552238806,0,"Marveld2"]
["Golgi apparatus","GO:0005794",9,67,1411,24814,0.0132411714155429,0.0510821462781201,2.3623131683891,0,"Chsy1, Cabp2, Ap3m2, Ap3s1, Gga1, Vti1a, Nedd4l, Myo6, Elmod1"]
["presynaptic endocytic zone","GO:0098833",1,67,5,24814,0.0134288116504336,0.0510821462781201,74.0716417910448,0,"Myo6"]
["subapical complex","GO:0035003",1,67,5,24814,0.0134288116504336,0.0510821462781201,74.0716417910448,0,"Mpdz"]
["postsynaptic density","GO:0014069",4,67,345,24814,0.0141673437854012,0.0518578244220345,4.29400821977071,0,"Mpdz, Nptn, Myo6, Homer2"]
["early endosome","GO:0005769",4,67,344,24814,0.0140310060966785,0.0518578244220345,4.30649080180493,0,"Ap3m2, Nisch, Ap3s1, Gga1"]
["stereocilia ankle link complex","GO:0002142",1,67,6,24814,0.0160931781956157,0.0538289063784386,61.726368159204,0,"Ush1c"]
["muscle tendon junction","GO:0005927",1,67,6,24814,0.0160931781956157,0.0538289063784386,61.726368159204,0,"Cib2"]
["clathrin-coated pit","GO:0005905",2,67,71,24814,0.015831728239988,0.0538289063784386,10.4326256043725,0,"Aak1, Myo6"]
["cochlear hair cell ribbon synapse","GO:0098683",1,67,6,24814,0.0160931781956157,0.0538289063784386,61.726368159204,0,"Myo6"]
["activin receptor complex","GO:0048179",1,67,6,24814,0.0160931781956157,0.0538289063784386,61.726368159204,0,"Acvr2a"]
["presynaptic active zone membrane","GO:0048787",2,67,76,24814,0.0180012601858262,0.0591905843398354,9.74626865671642,0,"Nptn, Atp2b1"]
["clathrin-sculpted glutamate transport vesicle membrane","GO:0060203",1,67,7,24814,0.018750456374465,0.0597180438320477,52.908315565032,0,"Slc17a8"]
["cell junction","GO:0030054",3,67,208,24814,0.0187773230605923,0.0597180438320477,5.34170493685419,0,"Gjb3, Marveld2, Ccdc88c"]
["nucleoplasm","GO:0005654",16,67,3477,24814,0.0207652208128806,0.0649750457693362,1.70426555745861,0,"Tprn, Rest, Baiap2l2, Nr2f1, Phf6, Nisch, Ankrd11, Atp2b1, Gga1, Ccdc92, Med28, Ewsr1, Myo6, Nin, Nfatc3, Klc2"]
["photoreceptor outer segment","GO:0001750",2,67,83,24814,0.021236591919559,0.0653952195618165,8.92429419169214,0,"Ush1c, Cib2"]
["collagen trimer","GO:0005581",2,67,84,24814,0.0217171569882967,0.0658301321207743,8.818052594172,0,"Col9a2, Col9a3"]
["brush border","GO:0005903",2,67,85,24814,0.0222022336686443,0.0662651281802616,8.71431079894644,0,"Ush1c, Myo6"]
["neuron projection","GO:0043005",4,67,398,24814,0.022635771261333,0.0665354488590698,3.72219305482637,0,"Mpdz, Slc17a8, Ppm1a, Klc2"]
["microtubule cytoskeleton","GO:0015630",3,67,228,24814,0.0238430137389061,0.0685956094748849,4.87313432835821,0,"Nisch, Clrn1, Nin"]
["bounding membrane of organelle","GO:0098588",1,67,9,24814,0.0240438218777947,0.0685956094748849,41.150912106136,0,"Vti1a"]
["filopodium","GO:0030175",2,67,90,24814,0.0246943469678439,0.0694304827791553,8.2301824212272,0,"Myo3a, Myo6"]
["centriolar subdistal appendage","GO:0120103",1,67,10,24814,0.0266799462049137,0.0709028707363461,37.0358208955224,0,"Nin"]
["supramolecular fiber","GO:0099512",1,67,10,24814,0.0266799462049137,0.0709028707363461,37.0358208955224,0,"Ocm"]
["ciliary transition fiber","GO:0097539",1,67,10,24814,0.0266799462049137,0.0709028707363461,37.0358208955224,0,"Nin"]
["intracellular organelle","GO:0043229",1,67,10,24814,0.0266799462049137,0.0709028707363461,37.0358208955224,0,"Homer2"]
["kinocilium","GO:0060091",1,67,11,24814,0.0293090561712204,0.076837255367794,33.6689280868385,0,"Grxcr1"]
["paranodal junction","GO:0033010",1,67,12,24814,0.0319311701589045,0.0815085133003614,30.863184079602,0,"Marveld2"]
["zymogen granule","GO:0042588",1,67,12,24814,0.0319311701589045,0.0815085133003614,30.863184079602,0,"Dnase1"]
["centrosome","GO:0005813",5,67,659,24814,0.0326316449774752,0.0822147938393532,2.81000158539624,0,"Triobp, Ccdc92, Ccdc88c, Nin, Eps8l2"]
["axon terminus","GO:0043679",2,67,106,24814,0.0333840094814387,0.0830320235820399,6.98789073500423,0,"Slc4a10, Slc17a8"]
["clathrin-coated endocytic vesicle","GO:0045334",1,67,13,24814,0.0345463065027217,0.0837747932691,28.4890929965557,0,"Myo6"]
["clathrin adaptor complex","GO:0030131",1,67,13,24814,0.0345463065027217,0.0837747932691,28.4890929965557,0,"Ap3m2"]
["ciliary rootlet","GO:0035253",1,67,16,24814,0.0423500323095455,0.100193978878681,23.1473880597015,0,"Klc2"]
["stereocilium bundle","GO:0032421",1,67,16,24814,0.0423500323095455,0.100193978878681,23.1473880597015,0,"Eps8l2"]
["photoreceptor ribbon synapse","GO:0098684",1,67,18,24814,0.0475179619750238,0.111066079797043,20.575456053068,0,"Atp2b1"]
["filopodium tip","GO:0032433",1,67,20,24814,0.052658417095017,0.113508143515926,18.5179104477612,0,"Myo3a"]
["postsynaptic actin cytoskeleton","GO:0098871",1,67,20,24814,0.052658417095017,0.113508143515926,18.5179104477612,0,"Myo6"]
["connexin complex","GO:0005922",1,67,20,24814,0.052658417095017,0.113508143515926,18.5179104477612,0,"Gjb3"]
["basolateral plasma membrane","GO:0016323",3,67,308,24814,0.0507374601299936,0.113508143515926,3.60738515216127,0,"Slc4a10, Marveld2, Atp2b1"]
["dendritic spine membrane","GO:0032591",1,67,19,24814,0.0500916148443443,0.113508143515926,19.4925373134328,0,"Atp2b1"]
["trans-Golgi network transport vesicle","GO:0030140",1,67,19,24814,0.0500916148443443,0.113508143515926,19.4925373134328,0,"Clrn1"]
["basal part of cell","GO:0045178",1,67,20,24814,0.052658417095017,0.113508143515926,18.5179104477612,0,"Clrn1"]
["endosome","GO:0005768",5,67,763,24814,0.055097041397095,0.117459626714686,2.4269869525244,0,"Nisch, Gga1, Vti1a, Spns2, Nedd4l"]
["somatodendritic compartment","GO:0036477",1,67,22,24814,0.0577715415324403,0.121822598448842,16.8344640434193,0,"Slc4a10"]
["peroxisome","GO:0005777",2,67,145,24814,0.0585973073537668,0.122235243297105,5.10838908903757,0,"Acsl4, Hsd17b4"]
["bicellular tight junction","GO:0005923",2,67,148,24814,0.0607453586921451,0.122756245690377,5.00484066155708,0,"Marveld2, Mpdz"]
["mitochondria-associated endoplasmic reticulum membrane contact site","GO:0044233",1,67,23,24814,0.0603178994994187,0.122756245690377,16.1025308241402,0,"Acsl4"]
["axon","GO:0030424",4,67,545,24814,0.0597949855655195,0.122756245690377,2.71822538682733,0,"Slc4a10, Emb, Myo6, Nin"]
["ER to Golgi transport vesicle membrane","GO:0012507",1,67,24,24814,0.0628574784084396,0.123298294352434,15.431592039801,0,"Vti1a"]
["pericentriolar material","GO:0000242",1,67,24,24814,0.0628574784084396,0.123298294352434,15.431592039801,0,"Nin"]
["Schaffer collateral - CA1 synapse","GO:0098685",2,67,151,24814,0.06292026361284,0.123298294352434,4.90540674112879,0,"Nptn, Myo6"]
["core mediator complex","GO:0070847",1,67,26,24814,0.0679163701061566,0.129174272554847,14.2445464982778,0,"Med28"]
["XY body","GO:0001741",1,67,26,24814,0.0679163701061566,0.129174272554847,14.2445464982778,0,"Ube2b"]
["neuron projection terminus","GO:0044306",1,67,26,24814,0.0679163701061566,0.129174272554847,14.2445464982778,0,"Vti1a"]
["Cul4-RING E3 ubiquitin ligase complex","GO:0080008",1,67,27,24814,0.0704357183070154,0.132665333510301,13.7169707020453,0,"Wdtc1"]
["centriole","GO:0005814",2,67,164,24814,0.0726416618737225,0.134780776240459,4.51656352384419,0,"Ccdc92, Nin"]
["cell-cell contact zone","GO:0044291",1,67,28,24814,0.0729483582744754,0.134780776240459,13.227078891258,0,"Baiap2l2"]
["apicolateral plasma membrane","GO:0016327",1,67,29,24814,0.0754543076005308,0.135538293282435,12.7709727225939,0,"Mpdz"]
["inhibitory synapse","GO:0060077",1,67,29,24814,0.0754543076005308,0.135538293282435,12.7709727225939,0,"Nptn"]
["apical junction complex","GO:0043296",1,67,29,24814,0.0754543076005308,0.135538293282435,12.7709727225939,0,"Ccdc88c"]
["membrane coat","GO:0030117",1,67,30,24814,0.0779535838317499,0.138743075810637,12.3452736318408,0,"Ap3s1"]
["replication fork","GO:0005657",1,67,32,24814,0.0829321869695131,0.144944542991762,11.5736940298507,0,"Ube2b"]
["peroxisomal matrix","GO:0005782",1,67,32,24814,0.0829321869695131,0.144944542991762,11.5736940298507,0,"Hsd17b4"]
["gap junction","GO:0005921",1,67,33,24814,0.0854115487431004,0.14794500407287,11.2229760289462,0,"Gjb3"]
["calyx of Held","GO:0044305",1,67,36,24814,0.0928100831406567,0.157939966046381,10.287728026534,0,"Aak1"]
["tight junction","GO:0070160",1,67,36,24814,0.0928100831406567,0.157939966046381,10.287728026534,0,"Marveld2"]
["mediator complex","GO:0016592",1,67,39,24814,0.10014965349099,0.167491661872863,9.49636433218523,0,"Med28"]
["neuronal cell body membrane","GO:0032809",1,67,39,24814,0.10014965349099,0.167491661872863,9.49636433218523,0,"Atp2b1"]
["cytoskeleton","GO:0005856",7,67,1481,24814,0.103791961242996,0.172099491291805,1.75051145353583,0,"Myo3a, Triobp, Ush1c, Ccdc92, Med28, Nin, Klc2"]
["mitotic spindle pole","GO:0097431",1,67,41,24814,0.105010171308169,0.172643840964278,9.03312704768839,0,"Nin"]
["presynaptic membrane","GO:0042734",2,67,205,24814,0.106056077240115,0.172898142727582,3.61325081907536,0,"Nptn, Atp2b1"]
["dendrite membrane","GO:0032590",1,67,44,24814,0.112252495058889,0.181474867011871,8.41723202170963,0,"Atp2b1"]
["SNARE complex","GO:0031201",1,67,46,24814,0.117048606340401,0.187664707686263,8.05126541207008,0,"Vti1a"]
["trans-Golgi network","GO:0005802",2,67,219,24814,0.118268253263053,0.188065910926494,3.38226674844953,0,"Ap3s1, Gga1"]
["excitatory synapse","GO:0060076",1,67,47,24814,0.119437081121376,0.188380436890626,7.87996189266434,0,"Slc17a8"]
["kinesin complex","GO:0005871",1,67,48,24814,0.121819191008115,0.189063384444595,7.7157960199005,0,"Klc2"]
["perikaryon","GO:0043204",2,67,222,24814,0.120930156659242,0.189063384444595,3.33656044103805,0,"Slc4a10, Slc17a8"]
["axonal growth cone","GO:0044295",1,67,49,24814,0.124194952705703,0.189931017659829,7.55833079500457,0,"Nin"]
["cilium","GO:0005929",3,67,454,24814,0.124336284756692,0.189931017659829,2.44730094023276,0,"Grxcr1, Ush1c, Elmod1"]
["multivesicular body","GO:0005771",1,67,50,24814,0.126564382876053,0.191824142796518,7.40716417910448,0,"Slc17a8"]
["chloride channel complex","GO:0034707",1,67,54,24814,0.135979120018516,0.204495730880559,6.85848535102266,0,"Slc17a8"]
["Cajal body","GO:0015030",1,67,56,24814,0.140648929481429,0.209891479379979,6.613539445629,0,"Ewsr1"]
["peroxisomal membrane","GO:0005778",1,67,58,24814,0.145293874528309,0.21516802792742,6.38548636129696,0,"Acsl4"]
["extracellular matrix","GO:0031012",2,67,257,24814,0.15298787206129,0.224845811968865,2.88216505023521,0,"Otog, Otogl"]
["extracellular region","GO:0005576",8,67,1974,24814,0.161433792408091,0.231986338719775,1.50094512241225,0,"Chsy1, Col9a2, Sema3f, Dnase1, Otog, Otogl, Ccdc88c, Otoa"]
["transcription repressor complex","GO:0017053",1,67,65,24814,0.161357251431084,0.231986338719775,5.69781859931114,0,"Rest"]
["cortical actin cytoskeleton","GO:0030864",1,67,64,24814,0.159080823762076,0.231986338719775,5.78684701492537,0,"Med28"]
["chromatin","GO:0000785",3,67,520,24814,0.165730194679373,0.233210367014201,2.13668197474168,0,"Rest, Ube2b, Ankrd11"]
["cytoplasmic microtubule","GO:0005881",1,67,67,24814,0.165891910556494,0.233210367014201,5.52773446201827,0,"Nin"]
["hippocampal mossy fiber to CA3 synapse","GO:0098686",1,67,67,24814,0.165891910556494,0.233210367014201,5.52773446201827,0,"Vti1a"]
["actin cytoskeleton","GO:0015629",2,67,272,24814,0.167200551359488,0.233359042904609,2.72322212467076,0,"Triobp, Myo6"]
["cell surface","GO:0009986",4,67,799,24814,0.169391267147366,0.234727898761351,1.8541086806269,0,"Kcne1, Nptn, Otoa, Acvr2a"]
["Golgi cisterna membrane","GO:0032580",1,67,72,24814,0.177123154996789,0.241985155418149,5.143864013267,0,"Chsy1"]
["endocytic vesicle","GO:0030139",1,67,72,24814,0.177123154996789,0.241985155418149,5.143864013267,0,"Myo6"]
["cell leading edge","GO:0031252",1,67,76,24814,0.186000775813221,0.252336716837517,4.87313432835821,0,"Aak1"]
["voltage-gated potassium channel complex","GO:0008076",1,67,77,24814,0.188205398176408,0.253554494765438,4.80984686954836,0,"Kcne1"]
["autophagosome","GO:0005776",1,67,78,24814,0.190404138457047,0.254747605935636,4.74818216609261,0,"Vti1a"]
["synaptic membrane","GO:0097060",1,67,87,24814,0.209930644462518,0.278948938532387,4.25699090753131,0,"Nptn"]
["terminal bouton","GO:0043195",1,67,92,24814,0.220577467090907,0.289135328484027,4.02563270603504,0,"Aak1"]
["collagen-containing extracellular matrix","GO:0062023",2,67,326,24814,0.219929312969283,0.289135328484027,2.27213625125904,0,"Col9a2, Col9a3"]
["intercellular bridge","GO:0045171",1,67,102,24814,0.24144887643196,0.314369678038928,3.63096283289435,0,"Nisch"]
["presynapse","GO:0098793",2,67,353,24814,0.246844313039852,0.319251978198209,2.09834679294744,0,"Aak1, Slc4a10"]
["lateral plasma membrane","GO:0016328",1,67,106,24814,0.24964241310615,0.320732636705914,3.49394536750211,0,"Slc4a10"]
["microtubule","GO:0005874",2,67,366,24814,0.259859532295776,0.331662824114346,2.0238153494821,0,"Nin, Klc2"]
["neuromuscular junction","GO:0031594",1,67,112,24814,0.261769511397136,0.331916896804211,3.3067697228145,0,"Cib2"]
["lipid droplet","GO:0005811",1,67,119,24814,0.275673928237415,0.347277545961419,3.11225385676659,0,"Acsl4"]
["cytoplasmic side of plasma membrane","GO:0009898",1,67,120,24814,0.277639097170725,0.347496676458843,3.0863184079602,0,"Atp2b1"]
["mitotic spindle","GO:0072686",1,67,134,24814,0.304606209228464,0.376392385925618,2.76386723100913,0,"Nin"]
["cell periphery","GO:0071944",1,67,134,24814,0.304606209228464,0.376392385925618,2.76386723100913,0,"Cib2"]
["monoatomic ion channel complex","GO:0034702",1,67,144,24814,0.323258802156811,0.395349364222724,2.5719320066335,0,"Kcne1"]
["recycling endosome","GO:0055037",1,67,148,24814,0.330581058750341,0.395349364222724,2.50242033077854,0,"Nisch"]
["late endosome membrane","GO:0031902",1,67,146,24814,0.326929739019747,0.395349364222724,2.53670006133715,0,"Vti1a"]
["side of membrane","GO:0098552",1,67,147,24814,0.328757844560758,0.395349364222724,2.51944359833486,0,"Otoa"]
["sarcolemma","GO:0042383",1,67,149,24814,0.332399394478215,0.395349364222724,2.48562556345788,0,"Cib2"]
["postsynaptic density membrane","GO:0098839",1,67,148,24814,0.330581058750341,0.395349364222724,2.50242033077854,0,"Nptn"]
["Z disc","GO:0030018",1,67,150,24814,0.334212864600653,0.395349364222724,2.46905472636816,0,"Kcne1"]
["spindle pole","GO:0000922",1,67,152,24814,0.33782525928761,0.397200607889674,2.4365671641791,0,"Nin"]
["chromosome, centromeric region","GO:0000775",1,67,163,24814,0.357350995357279,0.415126305983905,2.27213625125904,0,"Phf6"]
["extracellular space","GO:0005615",6,67,1797,24814,0.356968339528406,0.415126305983905,1.23658834375701,0,"Col9a2, Sema3f, Otog, Otogl, Ocm, Col9a3"]
["kinetochore","GO:0000776",1,67,168,24814,0.36603776648859,0.422686468445157,2.204513148543,0,"Phf6"]
["vesicle","GO:0031982",1,67,180,24814,0.386416883749814,0.440969855573317,2.0575456053068,0,"Ocm"]
["mitochondrion","GO:0005739",6,67,1855,24814,0.385515368606447,0.440969855573317,1.19792412600072,0,"Acsl4, Hsd17b4, Hars2, Clpp, Cyb5r2, Klc2"]
["perinuclear region of cytoplasm","GO:0048471",3,67,841,24814,0.397512685384465,0.450979303886469,1.32113510923385,0,"Cabp2, Vti1a, Myo6"]
["early endosome membrane","GO:0031901",1,67,193,24814,0.407766318571662,0.45992247559827,1.9189544505452,0,"Gga1"]
["endosome membrane","GO:0010008",1,67,204,24814,0.425258374546194,0.473911078607767,1.81548141644718,0,"Spns2"]
["receptor complex","GO:0043235",1,67,207,24814,0.429939947602923,0.473911078607767,1.78917009157113,0,"Acvr2a"]
["midbody","GO:0030496",1,67,206,24814,0.428383612347204,0.473911078607767,1.79785538327779,0,"Triobp"]
["lamellipodium","GO:0030027",1,67,203,24814,0.423689449802656,0.473911078607767,1.82442467465628,0,"Clrn1"]
["mitochondrial outer membrane","GO:0005741",1,67,209,24814,0.433040106104075,0.47463152872424,1.77204884667571,0,"Acsl4"]
["mitochondrial membrane","GO:0031966",1,67,211,24814,0.436123655295411,0.4753257816141,1.75525217514324,0,"Acsl4"]
["endomembrane system","GO:0012505",1,67,228,24814,0.461675487915316,0.500363377964086,1.62437810945274,0,"Vti1a"]
["cell-cell junction","GO:0005911",1,67,233,24814,0.468971225601756,0.505446765370781,1.58952021010826,0,"Gjb3"]
["membrane raft","GO:0045121",1,67,235,24814,0.471862170739863,0.505752823886924,1.57599237853287,0,"Kcne1"]
["nucleolus","GO:0005730",3,67,963,24814,0.484791610985802,0.513932090334675,1.15376389082624,0,"Phf6, Ewsr1, Nin"]
["nuclear envelope","GO:0005635",1,67,243,24814,0.483271720220575,0.513932090334675,1.52410785578281,0,"Dnase1"]
["mitochondrial matrix","GO:0005759",1,67,258,24814,0.504013983817463,0.531406048155369,1.43549693393498,0,"Clpp"]
["nuclear membrane","GO:0031965",1,67,270,24814,0.520015342293041,0.545313385972162,1.37169707020453,0,"Myo6"]
["transcription regulator complex","GO:0005667",1,67,299,24814,0.55661581540296,0.580556280581582,1.23865621724155,0,"Nfatc3"]
["endoplasmic reticulum membrane","GO:0005789",3,67,1094,24814,0.571586056629843,0.592982326129356,1.0156075199869,0,"Acsl4, Vti1a, Tram2"]
["postsynapse","GO:0098794",1,67,403,24814,0.66664335188485,0.68791920354075,0.919002999888893,0,"Slc4a10"]
["nucleus","GO:0005634",16,67,6469,24814,0.702576677250228,0.721163361833568,0.916019685157456,0,"Tprn, Rest, Nr2f1, Ube2b, Phf6, Ankrd11, Dnase1, Triobp, Med28, Ppm1a, Ewsr1, Wdtc1, Tox, Myo6, Ikzf5, Nfatc3"]
["lysosome","GO:0005764",1,67,487,24814,0.735471173788236,0.750954777446935,0.760489135431671,0,"Klc2"]
["Golgi membrane","GO:0000139",1,67,583,24814,0.797109009391006,0.809629046187723,0.635262794091293,0,"Vti1a"]
["chromosome","GO:0005694",1,67,671,24814,0.841053437599746,0.849814410908077,0.551949640767845,0,"Phf6"]
["endoplasmic reticulum","GO:0005783",2,67,1715,24814,0.950964131649752,0.955891406943274,0.431904616857404,0,"Tmtc4, Acsl4"]
["cellular_component","GO:0005575",1,67,6105,24814,0.999999994110875,0.999999994110875,0.060664735291601,0,"Zcchc14"]

{"sheet":"Supplementary Table S22.","index":22,"n_rows":192,"n_cols":11,"rows_kept":192}
["Supplementary Table S22.- Active biochemical pathways according to Gene Ontology - Molecular Function in Mus musculus."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["actin binding","GO:0003779",9,67,393,24273,{"v":1.30270469167902e-06,"d":"1.30E-06"},0.000246211186727335,8.29657058220349,0,"Tprn, Eps8l1, Myo3a, Dnase1, Triobp, Med28, Myo6, Homer2, Eps8l2"]
["alpha-L-arabinofuranosidase activity","GO:0046556",2,67,2,24273,{"v":7.50567437129742e-06,"d":"7.51E-06"},0.000709286228087606,362.283582089552,0,"Otog, Otogl"]
["actin filament binding","GO:0051015",5,67,225,24273,0.000396198054930792,0.0249604774606399,8.05074626865672,0,"Eps8l1, Myo3a, Triobp, Myo6, Eps8l2"]
["protein binding","GO:0005515",28,67,5671,24273,6.18666677727053E-4,0.0292320005226033,1.78873925207326,0,"Tprn, Rest, Gjb3, Klhl18, Ube2b, Marveld2, Kcne1, Mpdz, Nptn, Hsd17b4, Myo3a, Atp2b1, Gga1, Triobp, Ush1c, Cib2, Med28, Ewsr1, Tram2, Ccdc88c, Nedd4l, Myo6, Homer2, Clpp, Nin, Nfatc3, Klc2, Acvr2a"]
["transmembrane transporter binding","GO:0044325",4,67,176,24273,0.00143451996006802,0.0451873787421426,8.23371777476255,0,"Kcne1, Nptn, Ppm1a, Nedd4l"]
["identical protein binding","GO:0042802",14,67,2057,24273,1.2687806551641E-3,0.0451873787421426,2.4657122747952,0,"Rest, Baiap2l2, Nisch, Hsd17b4, Hars2, Gpr152, Ccdc92, Ewsr1, Ocm, Ccdc88c, Myo6, Homer2, Clpp, Acvr2a"]
["3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity","GO:0033989",1,67,1,24273,0.00276026861121411,0.0612919389754563,362.283582089552,0,"Hsd17b4"]
["(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity","GO:0106386",1,67,2,24273,5.51303154805692E-3,0.0612919389754563,181.141791044776,0,"Hsd17b4"]
["17-beta-hydroxysteroid dehydrogenase (NAD+) activity","GO:0044594",1,67,2,24273,5.51303154805692E-3,0.0612919389754563,181.141791044776,0,"Hsd17b4"]
["calmodulin binding","GO:0005516",4,67,202,24273,0.00237009227592306,0.0612919389754563,7.173932318605,0,"Myo3a, Atp2b1, Ewsr1, Myo6"]
["sphingolipid transporter activity","GO:0046624",1,67,2,24273,5.51303154805692E-3,0.0612919389754563,181.141791044776,0,"Spns2"]
["microfilament motor activity","GO:0000146",2,67,38,24273,0.00494881322363923,0.0612919389754563,19.0675569520817,0,"Myo3a, Myo6"]
["phosphatidylinositol binding","GO:0035091",3,67,115,24273,3.98103664656286E-3,0.0612919389754563,9.45087605451006,0,"Nisch, Zcchc14, Gga1"]
["PDZ domain binding","GO:0030165",3,67,124,24273,0.00491311391382184,0.0612919389754563,8.76492537313433,0,"Atp2b1, Ccdc88c, Acvr2a"]
["histidine-tRNA ligase activity","GO:0004821",1,67,2,24273,5.51303154805692E-3,0.0612919389754563,181.141791044776,0,"Hars2"]
["ubiquitin conjugating enzyme activity","GO:0061631",2,67,38,24273,0.00494881322363923,0.0612919389754563,19.0675569520817,0,"Ube2g1, Ube2b"]
["myosin tail binding","GO:0032029",1,67,2,24273,5.51303154805692E-3,0.0612919389754563,181.141791044776,0,"Ush1c"]
["potassium channel regulator activity","GO:0015459",2,67,44,24273,0.00658893679077482,0.0684696145213919,16.4674355495251,0,"Kcne1, Nedd4l"]
["extracellular matrix structural constituent conferring tensile strength","GO:0030020",2,67,45,24273,6.88318876140976E-3,0.0684696145213919,16.1014925373134,0,"Col9a2, Col9a3"]
["plus-end directed microfilament motor activity","GO:0060002",1,67,3,24273,0.0082583089114239,0.0709463811026872,120.761194029851,0,"Myo3a"]
["L-glutamate uniporter activity","GO:0140788",1,67,3,24273,0.0082583089114239,0.0709463811026872,120.761194029851,0,"Slc17a8"]
["sodium,bicarbonate:chloride antiporter activity","GO:0140892",1,67,3,24273,0.0082583089114239,0.0709463811026872,120.761194029851,0,"Slc4a10"]
["synaptic receptor adaptor activity","GO:0030160",1,67,4,24273,0.0109961207492045,0.0799333392922941,90.5708955223881,0,"Homer2"]
["N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity","GO:0050510",1,67,4,24273,0.0109961207492045,0.0799333392922941,90.5708955223881,0,"Chsy1"]
["DNA-binding transcription repressor activity, RNA polymerase II-specific","GO:0001227",4,67,308,24273,0.010417497791114,0.0799333392922941,4.7049815855786,0,"Rest, Nr2f1, Ikzf5, Nfatc3"]
["G protein-coupled glutamate receptor binding","GO:0035256",1,67,4,24273,0.0109961207492045,0.0799333392922941,90.5708955223881,0,"Homer2"]
["voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization","GO:0086008",1,67,5,24273,0.0137264870564196,0.0810720641769781,72.4567164179104,0,"Kcne1"]
["calmodulin-dependent protein phosphatase activity","GO:0033192",1,67,5,24273,0.0137264870564196,0.0810720641769781,72.4567164179104,0,"Ppm1a"]
["3-hydroxyacyl-CoA dehydrogenase activity","GO:0003857",1,67,5,24273,0.0137264870564196,0.0810720641769781,72.4567164179104,0,"Hsd17b4"]
["inhibin binding","GO:0034711",1,67,5,24273,0.0137264870564196,0.0810720641769781,72.4567164179104,0,"Acvr2a"]
["deoxyribonuclease I activity","GO:0004530",1,67,5,24273,0.0137264870564196,0.0810720641769781,72.4567164179104,0,"Dnase1"]
["activin receptor activity","GO:0017002",1,67,5,24273,0.0137264870564196,0.0810720641769781,72.4567164179104,0,"Acvr2a"]
["cytochrome-b5 reductase activity, acting on NAD(P)H","GO:0004128",1,67,6,24273,0.0164494277753589,0.0840254553930496,60.3805970149254,0,"Cyb5r2"]
["3-hydroxyacyl-CoA dehydratase activity","GO:0018812",1,67,6,24273,0.0164494277753589,0.0840254553930496,60.3805970149254,0,"Hsd17b4"]
["enoyl-CoA hydratase activity","GO:0004300",1,67,6,24273,0.0164494277753589,0.0840254553930496,60.3805970149254,0,"Hsd17b4"]
["type 1 fibroblast growth factor receptor binding","GO:0005105",1,67,6,24273,0.0164494277753589,0.0840254553930496,60.3805970149254,0,"Nptn"]
["sodium:bicarbonate symporter activity","GO:0008510",1,67,6,24273,0.0164494277753589,0.0840254553930496,60.3805970149254,0,"Slc4a10"]
["retinoic acid-responsive element binding","GO:0044323",1,67,7,24273,0.0191649627957179,0.0843677175396886,51.7547974413646,0,"Nr2f1"]
["sodium:phosphate symporter activity","GO:0005436",1,67,8,24273,0.0218731119547341,0.0843677175396886,45.285447761194,0,"Slc17a8"]
["BMP receptor activity","GO:0098821",1,67,8,24273,0.0218731119547341,0.0843677175396886,45.285447761194,0,"Acvr2a"]
["cytoskeletal motor activity","GO:0003774",2,67,78,24273,0.0196967946133804,0.0843677175396886,9.28932261768083,0,"Myo3a, Myo6"]
["telethonin binding","GO:0031433",1,67,7,24273,0.0191649627957179,0.0843677175396886,51.7547974413646,0,"Kcne1"]
["nucleotide binding","GO:0000166",10,67,1741,24273,0.0205378735455911,0.0843677175396886,2.08089363635584,0,"Ube2g1, Acsl4, Ube2b, Aak1, Hars2, Myo3a, Atp2b1, Myo6, Nin, Acvr2a"]
["active monoatomic ion transmembrane transporter activity","GO:0022853",1,67,8,24273,0.0218731119547341,0.0843677175396886,45.285447761194,0,"Slc4a10"]
["DNA nuclease activity","GO:0004536",1,67,7,24273,0.0191649627957179,0.0843677175396886,51.7547974413646,0,"Dnase1"]
["sodium channel inhibitor activity","GO:0019871",1,67,8,24273,0.0218731119547341,0.0843677175396886,45.285447761194,0,"Nedd4l"]
["glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity","GO:0047238",1,67,8,24273,0.0218731119547341,0.0843677175396886,45.285447761194,0,"Chsy1"]
["dolichyl-phosphate-mannose-protein mannosyltransferase activity","GO:0004169",1,67,8,24273,0.0218731119547341,0.0843677175396886,45.285447761194,0,"Tmtc4"]
["ATP-dependent peptidase activity","GO:0004176",1,67,8,24273,0.0218731119547341,0.0843677175396886,45.285447761194,0,"Clpp"]
["ATP binding","GO:0005524",9,67,1512,24273,0.0226321730029352,0.085549613951095,2.15644989339019,0,"Ube2g1, Acsl4, Ube2b, Aak1, Hars2, Myo3a, Atp2b1, Myo6, Acvr2a"]
["very long-chain fatty acid-CoA ligase activity","GO:0031957",1,67,9,24273,0.0245738950373235,0.0877722487095989,40.2537313432836,0,"Acsl4"]
["guanyl-nucleotide exchange factor activity","GO:0005085",3,67,227,24273,0.0249486953066135,0.0877722487095989,4.78788875008219,0,"Eps8l1, Ccdc88c, Eps8l2"]
["calcium ion transmembrane transporter activity","GO:0015085",1,67,9,24273,0.0245738950373235,0.0877722487095989,40.2537313432836,0,"Atp2b1"]
["protein homodimerization activity","GO:0042803",6,67,817,24273,0.0250777853455997,0.0877722487095989,2.66058934215093,0,"Col9a2, Ankrd11, Hsd17b4, Cib2, Ocm, Col9a3"]
["potassium channel inhibitor activity","GO:0019870",1,67,10,24273,0.0272673317762165,0.0920272447447307,36.2283582089552,0,"Nedd4l"]
["voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization","GO:1902282",1,67,10,24273,0.0272673317762165,0.0920272447447307,36.2283582089552,0,"Kcne1"]
["acetylgalactosaminyltransferase activity","GO:0008376",1,67,11,24273,0.0299534418520931,0.0943533418340932,32.9348710990502,0,"Chsy1"]
["activin binding","GO:0048185",1,67,11,24273,0.0299534418520931,0.0943533418340932,32.9348710990502,0,"Acvr2a"]
["arachidonate-CoA ligase activity","GO:0047676",1,67,11,24273,0.0299534418520931,0.0943533418340932,32.9348710990502,0,"Acsl4"]
["P-type calcium transporter activity","GO:0005388",1,67,11,24273,0.0299534418520931,0.0943533418340932,32.9348710990502,0,"Atp2b1"]
["ATPase binding","GO:0051117",2,67,100,24273,0.0312365800159741,0.09522118746805,7.24567164179104,0,"Tmtc4, Clpp"]
["ubiquitin-protein transferase activity","GO:0004842",3,67,247,24273,0.0309577346598759,0.09522118746805,4.40020545048039,0,"Ube2g1, Ube2b, Nedd4l"]
["AP-2 adaptor complex binding","GO:0035612",1,67,12,24273,0.0326322448937183,0.0963670982017617,30.1902985074627,0,"Aak1"]
["secondary active transmembrane transporter activity","GO:0015291",1,67,12,24273,0.0326322448937183,0.0963670982017617,30.1902985074627,0,"Slc4a10"]
["transmembrane receptor protein serine/threonine kinase activity","GO:0004675",1,67,13,24273,0.0353037604780767,0.102652472774715,27.8679678530425,0,"Acvr2a"]
["protein serine/threonine phosphatase inhibitor activity","GO:0004865",1,67,14,24273,0.0379680081305074,0.107103784129342,25.8773987206823,0,"Tprn"]
["L-glutamate transmembrane transporter activity","GO:0005313",1,67,14,24273,0.0379680081305074,0.107103784129342,25.8773987206823,0,"Slc17a8"]
["microtubule minus-end binding","GO:0051011",1,67,15,24273,0.0406250073248376,0.108142625132314,24.1522388059702,0,"Nin"]
["protein-containing complex binding","GO:0044877",5,67,679,24273,0.0394187226921404,0.108142625132314,2.66777306398787,0,"Rest, Kcne1, Cib2, Ocm, Homer2"]
["long-chain fatty acid-CoA ligase activity","GO:0004467",1,67,15,24273,0.0406250073248376,0.108142625132314,24.1522388059702,0,"Acsl4"]
["transforming growth factor beta receptor activity","GO:0005024",1,67,15,24273,0.0406250073248376,0.108142625132314,24.1522388059702,0,"Acvr2a"]
["symporter activity","GO:0015293",2,67,121,24273,0.0441618285581122,0.115711691703929,5.98815838164549,0,"Slc4a10, Slc17a8"]
["dynein heavy chain binding","GO:0045504",1,67,17,24273,0.0459173379777494,0.115711691703929,21.3107989464442,0,"Nisch"]
["mannosyltransferase activity","GO:0000030",1,67,17,24273,0.0459173379777494,0.115711691703929,21.3107989464442,0,"Tmtc4"]
["neurotransmitter transmembrane transporter activity","GO:0005326",1,67,17,24273,0.0459173379777494,0.115711691703929,21.3107989464442,0,"Slc17a8"]
["glutamate receptor binding","GO:0035254",1,67,18,24273,0.0485527081276295,0.117646946616948,20.1268656716418,0,"Homer2"]
["estradiol 17-beta-dehydrogenase [NAD(P)+] activity","GO:0004303",1,67,18,24273,0.0485527081276295,0.117646946616948,20.1268656716418,0,"Hsd17b4"]
["solute:inorganic anion antiporter activity","GO:0005452",1,67,18,24273,0.0485527081276295,0.117646946616948,20.1268656716418,0,"Slc4a10"]
["ion binding","GO:0043167",1,67,19,24273,0.0511809072022718,0.119422116805301,19.0675569520817,0,"Ocm"]
["monoatomic anion transmembrane transporter activity","GO:0008509",1,67,19,24273,0.0511809072022718,0.119422116805301,19.0675569520817,0,"Slc4a10"]
["cation binding","GO:0043169",1,67,19,24273,0.0511809072022718,0.119422116805301,19.0675569520817,0,"Ppm1a"]
["bicarbonate transmembrane transporter activity","GO:0015106",1,67,20,24273,0.053801954419945,0.12400694372402,18.1141791044776,0,"Slc4a10"]
["ligase activity","GO:0016874",2,67,139,24273,0.0565406412355094,0.12874917100616,5.21271341136046,0,"Acsl4, Hars2"]
["gap junction channel activity","GO:0005243",1,67,22,24273,0.0590226699040208,0.132164839528546,16.4674355495251,0,"Gjb3"]
["histone deacetylase binding","GO:0042826",2,67,143,24273,0.059439213544584,0.132164839528546,5.06690324600772,0,"Phf6, Wdtc1"]
["semaphorin receptor binding","GO:0030215",1,67,23,24273,0.0616223763539169,0.135425920126631,15.7514600908501,0,"Sema3f"]
["RNA polymerase II core promoter sequence-specific DNA binding","GO:0000979",1,67,24,24273,0.0642150073140937,0.139501567613376,15.0951492537313,0,"Rest"]
["ubiquitin protein ligase binding","GO:0031625",3,67,337,24273,0.0663862479023031,0.141857415178163,3.22507639842331,0,"Ube2g1, Ube2b, Triobp"]
["Notch binding","GO:0005112",1,67,25,24273,0.0668005817505635,0.141857415178163,14.4913432835821,0,"Aak1"]
["integrin binding","GO:0005178",2,67,155,24273,0.0684324514948749,0.143708148139237,4.67462686567164,0,"Nisch, Cib2"]
["R-SMAD binding","GO:0070412",1,67,27,24273,0.0719506366662674,0.147811634020919,13.4179104477612,0,"Ppm1a"]
["cell-cell adhesion mediator activity","GO:0098632",1,67,27,24273,0.0719506366662674,0.147811634020919,13.4179104477612,0,"Emb"]
["delayed rectifier potassium channel activity","GO:0005251",1,67,28,24273,0.0745151548277522,0.151434024327367,12.9386993603412,0,"Kcne1"]
["chemorepellent activity","GO:0045499",1,67,29,24273,0.0770726918302905,0.154965305914095,12.4925373134328,0,"Sema3f"]
["dynein light intermediate chain binding","GO:0051959",1,67,30,24273,0.079623266390898,0.156758305707081,12.0761194029851,0,"Ccdc88c"]
["histone binding","GO:0042393",2,67,169,24273,0.0794492383843948,0.156758305707081,4.28737966969884,0,"Phf6, Wdtc1"]
["sodium channel regulator activity","GO:0017080",1,67,32,24273,0.0847036028074541,0.165041040521741,11.3213619402985,0,"Nedd4l"]
["spectrin binding","GO:0030507",1,67,33,24273,0.0872334018508889,0.166536494442606,10.9782903663501,0,"Ush1c"]
["protein phosphatase 1 binding","GO:0008157",1,67,33,24273,0.0872334018508889,0.166536494442606,10.9782903663501,0,"Tprn"]
["T cell receptor binding","GO:0042608",1,67,35,24273,0.092272354208889,0.172668068767129,10.3509594882729,0,"Eps8l1"]
["SNAP receptor activity","GO:0005484",1,67,35,24273,0.092272354208889,0.172668068767129,10.3509594882729,0,"Vti1a"]
["calcium channel regulator activity","GO:0005246",1,67,36,24273,0.094781544417157,0.175624626420026,10.0634328358209,0,"Cabp2"]
["molecular function inhibitor activity","GO:0140678",1,67,37,24273,0.0972839018262445,0.17679478312654,9.79144816458249,0,"Atp2b1"]
["DNA-binding transcription factor activity","GO:0003700",4,67,631,24273,0.0966809456505264,0.17679478312654,2.2965678737848,0,"Rest, Nr2f1, Ikzf5, Nfatc3"]
["aminoacyl-tRNA ligase activity","GO:0004812",1,67,40,24273,0.104750160269569,0.188550288485225,9.05708955223881,0,"Hars2"]
["G-protein alpha-subunit binding","GO:0001965",1,67,42,24273,0.109693836578297,0.190203074433929,8.62579957356077,0,"Ccdc88c"]
["frizzled binding","GO:0005109",1,67,42,24273,0.109693836578297,0.190203074433929,8.62579957356077,0,"Ccdc88c"]
["protein phosphatase inhibitor activity","GO:0004864",1,67,42,24273,0.109693836578297,0.190203074433929,8.62579957356077,0,"Tprn"]
["ADP binding","GO:0043531",1,67,42,24273,0.109693836578297,0.190203074433929,8.62579957356077,0,"Myo3a"]
["transmembrane transporter activity","GO:0022857",2,67,211,24273,0.115356184832341,0.1972836753881,3.43396760274457,0,"Slc17a8, Spns2"]
["protein serine/threonine kinase activity","GO:0004674",3,67,430,24273,0.115865015704122,0.1972836753881,2.52755987504339,0,"Aak1, Myo3a, Acvr2a"]
["FAD binding","GO:0071949",1,67,45,24273,0.117058969233292,0.197537010581181,8.05074626865672,0,"Cyb5r2"]
["transporter activity","GO:0005215",1,67,46,24273,0.119500650307313,0.198119499193703,7.87573004542505,0,"Atp2b1"]
["coreceptor activity","GO:0015026",1,67,46,24273,0.119500650307313,0.198119499193703,7.87573004542505,0,"Acvr2a"]
["alpha-tubulin binding","GO:0043014",1,67,49,24273,0.126785854616925,0.206573504505162,7.39354249162352,0,"Nisch"]
["transferase activity","GO:0016740",8,67,1816,24273,0.126163950880618,0.206573504505162,1.59596291669406,0,"Ube2g1, Chsy1, Tmtc4, Ube2b, Aak1, Myo3a, Nedd4l, Acvr2a"]
["enzyme inhibitor activity","GO:0004857",1,67,51,24273,0.13160963627751,0.212600181679055,7.10359964881475,0,"Wdtc1"]
["nuclear receptor activity","GO:0004879",1,67,53,24273,0.136407166114555,0.216646675593705,6.83553928470853,0,"Nr2f1"]
["kinesin binding","GO:0019894",1,67,53,24273,0.136407166114555,0.216646675593705,6.83553928470853,0,"Klc2"]
["growth factor binding","GO:0019838",1,67,54,24273,0.138796130601357,0.2167972618484,6.7089552238806,0,"Acvr2a"]
["ribonucleoprotein complex binding","GO:0043021",1,67,54,24273,0.138796130601357,0.2167972618484,6.7089552238806,0,"Phf6"]
["calcium ion binding","GO:0005509",4,67,727,24273,0.141064937641571,0.218535026346369,1.99330719168942,0,"Cabp2, Cib2, Ocm, Nin"]
["magnesium ion binding","GO:0000287",2,67,241,24273,0.143070828100694,0.218804913326026,3.00650275592989,0,"Cib2, Ppm1a"]
["phosphoprotein binding","GO:0051219",1,67,56,24273,0.143554546309139,0.218804913326026,6.46934968017058,0,"Phf6"]
["phosphatase binding","GO:0019902",1,67,62,24273,0.157674939573208,0.23840450863469,5.84328358208955,0,"Tprn"]
["sequence-specific DNA binding","GO:0043565",3,67,502,24273,0.161273215098894,0.241909822648341,2.1650413272284,0,"Rest, Nr2f1, Nfatc3"]
["voltage-gated potassium channel activity","GO:0005249",1,67,65,24273,0.16464888503908,0.24502865568808,5.5735935706085,0,"Kcne1"]
["metal ion binding","GO:0046872",14,67,3865,24273,0.170477303921046,0.25172039407092,1.312282056728,0,"Rest, Chsy1, Cabp2, Nr2f1, Phf6, Zcchc14, Zfp719, Atp2b1, Cib2, Ppm1a, Ewsr1, Ocm, Ikzf5, Acvr2a"]
["manganese ion binding","GO:0030145",1,67,69,24273,0.173859069814648,0.254723753449368,5.25048669695003,0,"Ppm1a"]
["transcription cis-regulatory region binding","GO:0000976",2,67,276,24273,0.17694490235367,0.257250665729567,2.62524334847502,0,"Rest, Nfatc3"]
["tubulin binding","GO:0015631",1,67,73,24273,0.182969206616227,0.261978636745962,4.96278879574729,0,"Phf6"]
["protein kinase activity","GO:0004672",3,67,532,24273,0.181604417749612,0.261978636745962,2.04295253058018,0,"Aak1, Myo3a, Acvr2a"]
["RNA polymerase II cis-regulatory region sequence-specific DNA binding","GO:0000978",5,67,1102,24273,0.18770569893326,0.265631515990575,1.64375490966222,0,"Rest, Nr2f1, Zfp719, Ikzf5, Nfatc3"]
["SNARE binding","GO:0000149",1,67,76,24273,0.189736797136125,0.265631515990575,4.76688923802042,0,"Vti1a"]
["cell adhesion molecule binding","GO:0050839",1,67,76,24273,0.189736797136125,0.265631515990575,4.76688923802042,0,"Nptn"]
["myosin phosphatase activity","GO:0017018",1,67,77,24273,0.191980365950106,0.266796243857132,4.7049815855786,0,"Ppm1a"]
["chloride channel activity","GO:0005254",1,67,79,24273,0.196449160512294,0.271013805378275,4.58586812771585,0,"Slc17a8"]
["chromatin binding","GO:0003682",3,67,560,24273,0.201179980518879,0.275529103754117,1.94080490405117,0,"Rest, Ikzf5, Nfatc3"]
["scaffold protein binding","GO:0097110",1,67,88,24273,0.21625930933069,0.294050427794967,4.11685888738128,0,"Phf6"]
["protein serine/threonine phosphatase activity","GO:0004722",1,67,89,24273,0.218430515709638,0.294881196208011,4.07060204595003,0,"Ppm1a"]
["potassium channel activity","GO:0005267",1,67,90,24273,0.22059579669903,0.295692238128487,4.02537313432836,0,"Kcne1"]
["endonuclease activity","GO:0004519",1,67,92,24273,0.224908646172958,0.299350240328797,3.93786502271252,0,"Dnase1"]
["cis-regulatory region sequence-specific DNA binding","GO:0000987",1,67,94,24273,0.229197984659247,0.302926007696487,3.85408066052715,0,"Nfatc3"]
["protein domain specific binding","GO:0019904",2,67,332,24273,0.233259216374298,0.306152721491267,2.18243121740694,0,"Homer2, Ikzf5"]
["chromatin DNA binding","GO:0031490",1,67,98,24273,0.237706632944939,0.309838300873058,3.69677124581176,0,"Tox"]
["ubiquitin binding","GO:0043130",1,67,100,24273,0.241926193217291,0.313178428205945,3.62283582089552,0,"Gga1"]
["antiporter activity","GO:0015297",1,67,104,24273,0.250296407244524,0.321809666457246,3.48349598163031,0,"Slc4a10"]
["endopeptidase activity","GO:0004175",1,67,114,24273,0.270825709455303,0.345851750588191,3.17792615868028,0,"Clpp"]
["DNA binding","GO:0003677",7,67,1912,24273,0.274532359397307,0.348232321651617,1.32635202647849,0,"Rest, Nr2f1, Phf6, Dnase1, Tox, Ikzf5, Nfatc3"]
["protein phosphatase binding","GO:0019903",1,67,118,24273,0.278881478130048,0.35139066244386,3.07019984821654,0,"Tprn"]
["kinase activity","GO:0016301",3,67,673,24273,0.284237836002778,0.354208021010816,1.61493424408419,0,"Aak1, Myo3a, Acvr2a"]
["phospholipid binding","GO:0005543",1,67,121,24273,0.28486571001928,0.354208021010816,2.99407919082275,0,"Baiap2l2"]
["nuclease activity","GO:0004518",1,67,124,24273,0.290801016648922,0.359224785272197,2.92164179104478,0,"Dnase1"]
["transcription coregulator activity","GO:0003712",1,67,126,24273,0.294730901725551,0.361715197572267,2.87526652452026,0,"Ewsr1"]
["kinase binding","GO:0019900",1,67,127,24273,0.296687792005271,0.361767694767717,2.8526266306264,0,"Nin"]
["transcription factor binding","GO:0008134",1,67,134,24273,0.310237058222286,0.375864128230847,2.70360882156382,0,"Nfatc3"]
["structural molecule activity","GO:0005198",1,67,140,24273,0.321645818372184,0.387204201734667,2.58773987206823,0,"Otog"]
["phosphoprotein phosphatase activity","GO:0004721",1,67,150,24273,0.340248712992857,0.407006371871202,2.41522388059702,0,"Ppm1a"]
["zinc ion binding","GO:0008270",3,67,767,24273,0.355512670676778,0.422590533068623,1.41701531456148,0,"Nr2f1, Zcchc14, Ikzf5"]
["isomerase activity","GO:0016853",1,67,161,24273,0.360131739544729,0.425405617337212,2.25020858440716,0,"Hsd17b4"]
["lyase activity","GO:0016829",1,67,172,24273,0.379424225499147,0.445411047325086,2.10629989586949,0,"Hsd17b4"]
["serine-type peptidase activity","GO:0008236",1,67,181,24273,0.394781832596211,0.45970475570014,2.00156675187598,0,"Clpp"]
["protein dimerization activity","GO:0046983",1,67,182,24273,0.396464948037687,0.45970475570014,1.99056913236018,0,"Ccdc88c"]
["RNA polymerase II-specific DNA-binding transcription factor binding","GO:0061629",1,67,202,24273,0.429175280641669,0.49160077600773,1.79348307965125,0,"Rest"]
["serine-type endopeptidase activity","GO:0004252",1,67,201,24273,0.427582060221048,0.49160077600773,1.80240588104255,0,"Clpp"]
["sequence-specific double-stranded DNA binding","GO:1990837",2,67,548,24273,0.448569740751989,0.507662760491772,1.32220285434143,0,"Nr2f1, Nfatc3"]
["nucleic acid binding","GO:0003676",2,67,548,24273,0.448569740751989,0.507662760491772,1.32220285434143,0,"Zcchc14, Ewsr1"]
["glycosyltransferase activity","GO:0016757",1,67,235,24273,0.479370023370918,0.539291276292283,1.54163226421086,0,"Chsy1"]
["GTPase activator activity","GO:0005096",1,67,242,24273,0.489444619993946,0.547308016575094,1.49703959541137,0,"Elmod1"]
["histone H2AS1 kinase activity","GO:0044024",1,67,244,24273,0.492287633956434,0.547308016575094,1.48476877905554,0,"Aak1"]
["microtubule binding","GO:0008017",1,67,270,24273,0.527857785867349,0.580029776330982,1.34179104477612,0,"Ccdc88c"]
["oxidoreductase activity","GO:0016491",2,67,635,24273,0.526304473272805,0.580029776330982,1.14105065225056,0,"Hsd17b4, Cyb5r2"]
["small GTPase binding","GO:0031267",1,67,301,24273,0.567070833942929,0.619516691417419,1.20359994049685,0,"Gga1"]
["catalytic activity","GO:0003824",1,67,332,24273,0.603071701271414,0.655060641036191,1.09121560870347,0,"Dnase1"]
["ubiquitin protein ligase activity","GO:0061630",1,67,346,24273,0.618347537695589,0.667815340711237,1.04706237598136,0,"Nedd4l"]
["protein serine kinase activity","GO:0106310",1,67,356,24273,0.628902804792158,0.675355852873397,1.01765051148751,0,"Aak1"]
["lipid binding","GO:0008289",1,67,362,24273,0.635097376548212,0.678154825805718,1.00078337593799,0,"Baiap2l2"]
["GTP binding","GO:0005525",1,67,380,24273,0.653076355599515,0.693435006788249,0.953377847604085,0,"Nin"]
["RNA polymerase II transcription regulatory region sequence-specific DNA binding","GO:0000977",1,67,399,24273,0.67110763809789,0.708599684919002,0.907978902480081,0,"Ikzf5"]
["ATP hydrolysis activity","GO:0016887",1,67,416,24273,0.686456340404818,0.716796952135418,0.870873995407578,0,"Atp2b1"]
["signaling receptor binding","GO:0005102",1,67,416,24273,0.686456340404818,0.716796952135418,0.870873995407578,0,"Sema3f"]
["enzyme binding","GO:0019899",1,67,463,24273,0.725313529412689,0.753210203620869,0.782469939718255,0,"Phf6"]
["RNA binding","GO:0003723",2,67,931,24273,0.733171482790923,0.757209892062757,0.778267630697212,0,"Hars2, Ewsr1"]
["peptidase activity","GO:0008233",1,67,521,24273,0.766776943878875,0.787613273875584,0.695361961784169,0,"Clpp"]
["DNA-binding transcription activator activity, RNA polymerase II-specific","GO:0001228",1,67,531,24273,0.773274066562067,0.789993505839085,0.68226663293701,0,"Nfatc3"]
["DNA-binding transcription factor activity, RNA polymerase II-specific","GO:0000981",2,67,1052,24273,0.793097171346653,0.805889061207083,0.688752057204472,0,"Zfp719, Nfatc3"]
["hydrolase activity","GO:0016787",3,67,1696,24273,0.855897922424444,0.865051910899571,0.640831807941425,0,"Dnase1, Ppm1a, Clpp"]
["G protein-coupled receptor activity","GO:0004930",1,67,1778,24273,0.993927639134338,0.99921448827867,0.203759045044743,0,"Gpr152"]
["molecular_function","GO:0003674",8,67,7573,24273,0.999941686082516,0.999941686082516,0.382710769406631,0,"Tprn, Grxcr1, Ankrd11, Zcchc14, Ccdc92, Otogl, Mpzl2, Otoa"]

{"sheet":"Supplementary Table S23.","index":23,"n_rows":78,"n_cols":11,"rows_kept":78}
["Supplementary Table S23.- Active biochemical pathways according to KEGG Reactome in Mus musculus."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["Fatty acid metabolism","mmu01212",2,32,61,9242,0.0187183955369542,0.378809191255032,9.46926229508197,0,"Acsl4, Hsd17b4"]
["Tight junction","mmu04530",3,32,169,9242,0.0202031568669351,0.378809191255032,5.12684911242604,0,"Marveld2, Mpdz, Nedd4l"]
["Ubiquitin mediated proteolysis","mmu04120",3,32,154,9242,0.0158022167278214,0.378809191255032,5.62621753246753,0,"Ube2g1, Ube2b, Nedd4l"]
["Lysosome","mmu04142",3,32,134,9242,0.0108750902282699,0.378809191255032,6.46595149253731,0,"Ap3m2, Ap3s1, Gga1"]
["ECM-receptor interaction","mmu04512",2,32,89,9242,0.0377301676519936,0.40425179627136,6.49016853932584,0,"Col9a2, Col9a3"]
["Motor proteins","mmu04814",3,32,198,9242,0.0304547940536463,0.40425179627136,4.37594696969697,0,"Myo3a, Myo6, Klc2"]
["Peroxisome","mmu04146",2,32,87,9242,0.0361979371847836,0.40425179627136,6.63936781609195,0,"Acsl4, Hsd17b4"]
["Fatty acid biosynthesis","mmu00061",1,32,18,9242,0.0605774600481133,0.413753779708034,16.0451388888889,0,"Acsl4"]
["Protein digestion and absorption","mmu04974",2,32,108,9242,0.0534671839571684,0.413753779708034,5.34837962962963,0,"Col9a2, Col9a3"]
["Glutamatergic synapse","mmu04724",2,32,116,9242,0.0606838876905117,0.413753779708034,4.97952586206897,0,"Slc17a8, Homer2"]
["Primary bile acid biosynthesis","mmu00120",1,32,18,9242,0.0605774600481133,0.413753779708034,16.0451388888889,0,"Hsd17b4"]
["Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate","mmu00532",1,32,21,9242,0.0703217973828879,0.439511233643049,13.7529761904762,0,"Chsy1"]
["Axon guidance","mmu04360",2,32,181,9242,0.129281608679752,0.452817384930354,3.19129834254144,0,"Sema3f, Nfatc3"]
["Signaling pathways regulating pluripotency of stem cells","mmu04550",2,32,140,9242,0.0841494780677416,0.452817384930354,4.12589285714286,0,"Rest, Acvr2a"]
["Wnt signaling pathway","mmu04310",2,32,175,9242,0.122352467020645,0.452817384930354,3.30071428571429,0,"Ccdc88c, Nfatc3"]
["Ferroptosis","mmu04216",1,32,41,9242,0.132826432912904,0.452817384930354,7.04420731707317,0,"Acsl4"]
["Nicotine addiction","mmu05033",1,32,40,9242,0.129800309232774,0.452817384930354,7.2203125,0,"Slc17a8"]
["Adrenergic signaling in cardiomyocytes","mmu04261",2,32,156,9242,0.10110158016735,0.452817384930354,3.70272435897436,0,"Kcne1, Atp2b1"]
["SNARE interactions in vesicular transport","mmu04130",1,32,32,9242,0.105220253298785,0.452817384930354,9.025390625,0,"Vti1a"]
["Biosynthesis of unsaturated fatty acids","mmu01040",1,32,34,9242,0.111427584187065,0.452817384930354,8.49448529411765,0,"Hsd17b4"]
["cGMP-PKG signaling pathway","mmu04022",2,32,171,9242,0.117788049421146,0.452817384930354,3.37792397660819,0,"Atp2b1, Nfatc3"]
["Aldosterone-regulated sodium reabsorption","mmu04960",1,32,38,9242,0.123717341521656,0.452817384930354,7.60032894736842,0,"Nedd4l"]
["Aminoacyl-tRNA biosynthesis","mmu00970",1,32,44,9242,0.141843763157473,0.462534010296107,6.56392045454545,0,"Hars2"]
["Fatty acid degradation","mmu00071",1,32,52,9242,0.165448145559157,0.477254266036029,5.55408653846154,0,"Acsl4"]
["Amino sugar and nucleotide sugar metabolism","mmu00520",1,32,51,9242,0.162532362248522,0.477254266036029,5.66299019607843,0,"Cyb5r2"]
["Focal adhesion","mmu04510",2,32,202,9242,0.15422499601041,0.477254266036029,2.8595297029703,0,"Col9a2, Col9a3"]
["Mineral absorption","mmu04978",1,32,55,9242,0.174136610156437,0.483712805990102,5.25113636363636,0,"Atp2b1"]
["Endocrine and other factor-regulated calcium reabsorption","mmu04961",1,32,61,9242,0.191251424893094,0.494795372314336,4.73463114754098,0,"Atp2b1"]
["Cytoskeleton in muscle cells","mmu04820",2,32,232,9242,0.191320877294877,0.494795372314336,2.48976293103448,0,"Col9a2, Col9a3"]
["Salmonella infection","mmu05132",2,32,251,9242,0.215434185835228,0.507438150777677,2.30129482071713,0,"Myo6, Klc2"]
["Synaptic vesicle cycle","mmu04721",1,32,77,9242,0.235228147747926,0.507438150777677,3.75081168831169,0,"Slc17a8"]
["Th1 and Th2 cell differentiation","mmu04658",1,32,88,9242,0.264108768144223,0.507438150777677,3.28196022727273,0,"Nfatc3"]
["Parkinson disease","mmu05012",2,32,261,9242,0.228255073239417,0.507438150777677,2.21312260536399,0,"Ube2g1, Klc2"]
["Calcium signaling pathway","mmu04020",2,32,253,9242,0.217992358555157,0.507438150777677,2.28310276679842,0,"Atp2b1, Nfatc3"]
["Huntington disease","mmu05016",2,32,295,9242,0.272212068858871,0.507438150777677,1.95805084745763,0,"Rest, Klc2"]
["PPAR signaling pathway","mmu03320",1,32,89,9242,0.266681252240726,0.507438150777677,3.24508426966292,0,"Acsl4"]
["MAPK signaling pathway","mmu04010",2,32,299,9242,0.27739952242513,0.507438150777677,1.93185618729097,0,"Ppm1a, Nfatc3"]
["Salivary secretion","mmu04970",1,32,87,9242,0.261527542733789,0.507438150777677,3.31968390804598,0,"Atp2b1"]
["B cell receptor signaling pathway","mmu04662",1,32,80,9242,0.243211782221868,0.507438150777677,3.61015625,0,"Nfatc3"]
["PD-L1 expression and PD-1 checkpoint pathway in cancer","mmu05235",1,32,88,9242,0.264108768144223,0.507438150777677,3.28196022727273,0,"Nfatc3"]
["Adipocytokine signaling pathway","mmu04920",1,32,72,9242,0.221740440396465,0.507438150777677,4.01128472222222,0,"Acsl4"]
["Aldosterone synthesis and secretion","mmu04925",1,32,102,9242,0.299340998882102,0.534537498003754,2.83149509803922,0,"Atp2b1"]
["Th17 cell differentiation","mmu04659",1,32,105,9242,0.306675282583482,0.534898748692119,2.75059523809524,0,"Nfatc3"]
["T cell receptor signaling pathway","mmu04660",1,32,122,9242,0.346852204161034,0.535860021824098,2.36731557377049,0,"Nfatc3"]
["PI3K-Akt signaling pathway","mmu04151",2,32,361,9242,0.357240014549399,0.535860021824098,1.60006925207756,0,"Col9a2, Col9a3"]
["TGF-beta signaling pathway","mmu04350",1,32,110,9242,0.318734120413303,0.535860021824098,2.62556818181818,0,"Acvr2a"]
["ATP-dependent chromatin remodeling","mmu03082",1,32,125,9242,0.353704097402733,0.535860021824098,2.3105,0,"Phf6"]
["Human papillomavirus infection","mmu05165",2,32,350,9242,0.343216907382125,0.535860021824098,1.65035714285714,0,"Col9a2, Col9a3"]
["Pancreatic secretion","mmu04972",1,32,115,9242,0.330589665257383,0.535860021824098,2.51141304347826,0,"Atp2b1"]
["C-type lectin receptor signaling pathway","mmu04625",1,32,112,9242,0.323500546492976,0.535860021824098,2.57868303571429,0,"Nfatc3"]
["FoxO signaling pathway","mmu04068",1,32,133,9242,0.371637126978451,0.545534055925136,2.17152255639098,0,"Homer2"]
["Yersinia infection","mmu05135",1,32,136,9242,0.378236945441427,0.545534055925136,2.12362132352941,0,"Nfatc3"]
["Retrograde endocannabinoid signaling","mmu04723",1,32,146,9242,0.399754893555584,0.561070911711681,1.97816780821918,0,"Slc17a8"]
["Fluid shear stress and atherosclerosis","mmu05418",1,32,148,9242,0.40397105643241,0.561070911711681,1.95143581081081,0,"Acvr2a"]
["Oxytocin signaling pathway","mmu04921",1,32,153,9242,0.414386334181209,0.565072273883467,1.88766339869281,0,"Nfatc3"]
["Hepatitis B","mmu05161",1,32,158,9242,0.424625201750203,0.566690856421875,1.82792721518987,0,"Nfatc3"]
["Efferocytosis","mmu04148",1,32,161,9242,0.430685050880625,0.566690856421875,1.79386645962733,0,"Nfatc3"]
["Protein processing in endoplasmic reticulum","mmu04141",1,32,174,9242,0.456237508263406,0.589962295168197,1.65984195402299,0,"Ube2g1"]
["Cellular senescence","mmu04218",1,32,179,9242,0.465766516411747,0.592076080184424,1.61347765363129,0,"Nfatc3"]
["Pathways of neurodegeneration - multiple diseases","mmu05022",2,32,468,9242,0.487134982976955,0.608918728721194,1.23424145299145,0,"Ube2g1, Klc2"]
["Lipid and atherosclerosis","mmu05417",1,32,211,9242,0.523030857987716,0.628332307983799,1.36877962085308,0,"Nfatc3"]
["Thermogenesis","mmu04714",1,32,224,9242,0.544554666919293,0.628332307983799,1.28934151785714,0,"Acsl4"]
["Kaposi sarcoma-associated herpesvirus infection","mmu05167",1,32,214,9242,0.528083678042537,0.628332307983799,1.34959112149533,0,"Nfatc3"]
["cAMP signaling pathway","mmu04024",1,32,224,9242,0.544554666919293,0.628332307983799,1.28934151785714,0,"Atp2b1"]
["Transcriptional misregulation in cancer","mmu05202",1,32,209,9242,0.519633236671405,0.628332307983799,1.38187799043062,0,"Ewsr1"]
["Human immunodeficiency virus 1 infection","mmu05170",1,32,232,9242,0.557329156692721,0.633328587150819,1.24488146551724,0,"Nfatc3"]
["Human T-cell leukemia virus 1 infection","mmu05166",1,32,244,9242,0.575842363580499,0.6367839869476,1.18365778688525,0,"Nfatc3"]
["Human cytomegalovirus infection","mmu05163",1,32,245,9242,0.57735081483249,0.6367839869476,1.17882653061225,0,"Nfatc3"]
["Endocytosis","mmu04144",1,32,266,9242,0.607853954719613,0.651272094342443,1.08576127819549,0,"Nedd4l"]
["Prion disease","mmu05020",1,32,260,9242,0.599363487911019,0.651272094342443,1.11081730769231,0,"Klc2"]
["Cytokine-cytokine receptor interaction","mmu04060",1,32,286,9242,0.634915131196942,0.670684997743248,1.00983391608392,0,"Acvr2a"]
["Amyotrophic lateral sclerosis","mmu05014",1,32,360,9242,0.720174777434946,0.750182059828068,0.802256944444445,0,"Klc2"]
["Alzheimer disease","mmu05010",1,32,376,9242,0.735889512430251,0.75605086893519,0.76811835106383,0,"Klc2"]
["Herpes simplex virus 1 infection","mmu05168",1,32,443,9242,0.792900473438763,0.803615344701449,0.651946952595937,0,"Zfp719"]
["Metabolic pathways","mmu01100",3,32,1625,9242,0.937874077806577,0.937874077806577,0.533192307692308,0,"Chsy1, Acsl4, Hsd17b4"]

{"sheet":"Supplementary Table S24.","index":24,"n_rows":57,"n_cols":11,"rows_kept":57}
["Supplementary Table S24.- Possible Transcription Factors according to CollecTRI in Mus musculus."]
[]
["description","annotation_id","genes_found","input_size","term_genes","universe","pval","pval_adj","relative_enrichment","annotsbias","genes"]
["Pou4f3","Pou4f3",1,22,6,5921,0.0220967156069291,0.596611321387087,44.8560606060606,0,"Myo6"]
["Zeb1","Zeb1",2,22,59,5921,0.0198426667484994,0.596611321387087,9.12326656394453,0,"Rest, Sema3f"]
["Egr2","Egr2",1,22,70,5921,0.230572662763514,0.608000048051451,3.84480519480519,0,"Gjb3"]
["Hes1","Hes1",1,22,92,5921,0.291875210235334,0.608000048051451,2.925395256917,0,"Rest"]
["Ctnnb1","Ctnnb1",2,22,340,5921,0.362997467218542,0.608000048051451,1.5831550802139,0,"Rest, Ube2b"]
["Rora","Rora",1,22,88,5921,0.281087732950327,0.608000048051451,3.05836776859504,0,"Sema3f"]
["Relb","Relb",1,22,58,5921,0.195032575311171,0.608000048051451,4.64028213166144,0,"Clpp"]
["Taf1","Taf1",1,22,43,5921,0.148400879459829,0.608000048051451,6.25898520084567,0,"Ube2b"]
["Sp1","Sp1",6,22,1255,5921,0.316675795408466,0.608000048051451,1.28670771459616,0,"Rest, Acsl4, Ube2b, Kcne1, Emb, Hsd17b4"]
["Foxm1","Foxm1",1,22,95,5921,0.299864234832356,0.608000048051451,2.83301435406699,0,"Nfatc3"]
["Zbtb7b","Zbtb7b",1,22,18,5921,0.0648999161884451,0.608000048051451,14.9520202020202,0,"Tox"]
["Runx2","Runx2",1,22,137,5921,0.403062857564455,0.608000048051451,1.96449900464499,0,"Tram2"]
["Twist2","Twist2",1,22,34,5921,0.119195854146166,0.608000048051451,7.91577540106952,0,"Nr2f1"]
["Id2","Id2",1,22,61,5921,0.204061697188707,0.608000048051451,4.41207153502235,0,"Sema3f"]
["Myod1","Myod1",1,22,136,5921,0.400784076177403,0.608000048051451,1.97894385026738,0,"Dnase1"]
["Creb1","Creb1",3,22,448,5921,0.229558960529654,0.608000048051451,1.80225243506494,0,"Rest, Nr2f1, Acsl4"]
["Mef2c","Mef2c",1,22,89,5921,0.283799214156412,0.608000048051451,3.02400408580184,0,"Nr2f1"]
["Tcf3","Tcf3",1,22,119,5921,0.360750746239448,0.608000048051451,2.26165011459129,0,"Sema3f"]
["Twist1","Twist1",1,22,76,5921,0.24777606022119,0.608000048051451,3.54126794258373,0,"Nr2f1"]
["Tfap2a","Tfap2a",2,22,304,5921,0.313012563416274,0.608000048051451,1.77063397129187,0,"Kcne1, Wdtc1"]
["Nkx2-5","Nkx2-5",1,22,71,5921,0.233465741112378,0.608000048051451,3.79065300896287,0,"Nr2f1"]
["Neurod2","Neurod2",1,22,13,5921,0.0472872238798633,0.608000048051451,20.7027972027972,0,"Rest"]
["Sox9","Sox9",1,22,102,5921,0.318172066737615,0.608000048051451,2.63859180035651,0,"Col9a2"]
["Ssrp1","Ssrp1",1,22,138,5921,0.405333365367634,0.608000048051451,1.95026350461133,0,"Wdtc1"]
["Thra","Thra",1,22,78,5921,0.253428478690757,0.608000048051451,3.4504662004662,0,"Kcne1"]
["Tox","Tox",1,22,14,5921,0.050834901786878,0.608000048051451,19.224025974026,0,"Tox"]
["Gata3","Gata3",2,22,177,5921,0.139167571662592,0.608000048051451,3.04108885464818,0,"Atp2b1, Tox"]
["Nr1h4","Nr1h4",1,22,122,5921,0.367996160597774,0.608000048051451,2.20603576751118,0,"Nisch"]
["Gli2","Gli2",1,22,138,5921,0.405333365367634,0.608000048051451,1.95026350461133,0,"Nr2f1"]
["Esrrg","Esrrg",1,22,26,5921,0.0924353896901631,0.608000048051451,10.3513986013986,0,"Dnase1"]
["Snai1","Snai1",1,22,95,5921,0.299864234832356,0.608000048051451,2.83301435406699,0,"Sema3f"]
["Ar","Ar",3,22,584,5921,0.371452964211267,0.608000048051451,1.3825498132005,0,"Rest, Ube2b, Dnase1"]
["Ncor2","Ncor2",1,22,79,5921,0.256239461656494,0.608000048051451,3.40678941311853,0,"Nr2f1"]
["Runx3","Runx3",1,22,63,5921,0.210027315476014,0.608000048051451,4.27200577200577,0,"Dnase1"]
["Tcf7l2","Tcf7l2",1,22,110,5921,0.338535718893646,0.608000048051451,2.44669421487603,0,"Ube2b"]
["Smarca1","Smarca1",1,22,64,5921,0.21299409578662,0.608000048051451,4.20525568181818,0,"Dnase1"]
["Tp53","Tp53",4,22,915,5921,0.448875844310737,0.655116097102157,1.17655240933929,0,"Ube2b, Ankrd11, Ppm1a, Myo6"]
["Cebpg","Cebpg",1,22,186,5921,0.505127781985903,0.667790550101921,1.4469696969697,0,"Wdtc1"]
["Sp3","Sp3",2,22,435,5921,0.488197134996499,0.667790550101921,1.23740856844305,0,"Rest, Dnase1"]
["Foxo3","Foxo3",1,22,187,5921,0.507026158410718,0.667790550101921,1.43923189110355,0,"Sema3f"]
["Gli1","Gli1",1,22,170,5921,0.473788105555657,0.667790550101921,1.5831550802139,0,"Emb"]
["Myb","Myb",1,22,200,5921,0.531081118806763,0.680401998012404,1.34568181818182,0,"Atp2b1"]
["Nr1i2","Nr1i2",1,22,206,5921,0.541801591009877,0.680401998012404,1.30648720211827,0,"Ube2b"]
["Ets1","Ets1",1,22,218,5921,0.562544825563424,0.690395922282384,1.23457047539616,0,"Nr2f1"]
["Foxo1","Foxo1",1,22,265,5921,0.635481434360354,0.719684137260046,1.0156089193825,0,"Sema3f"]
["Ppara","Ppara",1,22,257,5921,0.62394676019884,0.719684137260046,1.04722320481075,0,"Hsd17b4"]
["Yy1","Yy1",1,22,262,5921,0.631196079715629,0.719684137260046,1.02723802914643,0,"Rest"]
["Hnf4a","Hnf4a",1,22,268,5921,0.639719233120041,0.719684137260046,1.00424016282225,0,"Ube2b"]
["Fos","Fos",1,22,379,5921,0.767292429986431,0.845587575903413,0.710122331494363,0,"Ube2b"]
["Stat3","Stat3",1,22,423,5921,0.804788241574743,0.852128726373257,0.63625617880937,0,"Ube2g1"]
["Nfkb1","Nfkb1",1,22,413,5921,0.796810387575085,0.852128726373257,0.651661897424609,0,"Ube2b"]
["Hif1a","Hif1a",1,22,445,5921,0.821300243579026,0.852888714485912,0.604800817160368,0,"Dnase1"]
["Myc","Myc",2,22,919,5921,0.877138635416666,0.893688420990565,0.585715698882184,0,"Acsl4, Nfatc3"]
["Jun","Jun",1,22,674,5921,0.930310076415319,0.930310076415319,0.399312112220124,0,"Ube2b"]

{"sheet":"Supplementary Table S25.","index":25,"n_rows":165,"n_cols":13,"rows_kept":165}
["Supplementary Table S25. – Protein-Protein Interaction Networks According to STRING in Homo Sapiens. "]
[]
["#node1","node2","node1_string_id","node2_string_id","neighborhood_on_chromosome","gene_fusion","phylogenetic_cooccurrence","homology","coexpression","experimentally_determined_interaction","database_annotated","automated_textmining","combined_score"]
["AAK1","NEDD4L","9606.ENSP00000386456","9606.ENSP00000383199",0,0,0,0,0,0,0,0.412,0.412]
["ACSL4","HSD17B4","9606.ENSP00000339787","9606.ENSP00000411960",0,0,0,0,0,0,0.218,0.337,0.459]
["ANKRD11","ZCCHC14","9606.ENSP00000301030","9606.ENSP00000268616",0,0,0,0,0,0.05,0,0.417,0.423]
["AP3M2","AP3S1","9606.ENSP00000428787","9606.ENSP00000325369",0,0,0,0,0,0.777,0.9,0.656,0.991]
["AP3S1","AP3M2","9606.ENSP00000325369","9606.ENSP00000428787",0,0,0,0,0,0.777,0.9,0.656,0.991]
["ATP2B1","TRAM2","9606.ENSP00000392043","9606.ENSP00000182527",0,0,0,0,0,0,0,0.427,0.426]
["ATP2B1","NPTN","9606.ENSP00000392043","9606.ENSP00000290401",0,0,0,0,0,0.36,0,0.619,0.746]
["ATP2B1","SLC17A8","9606.ENSP00000392043","9606.ENSP00000316909",0,0,0,0,0,0,0,0.46,0.46]
["CABP2","MYO6","9606.ENSP00000294288","9606.ENSP00000358994",0,0,0,0,0,0.301,0,0.199,0.416]
["CABP2","GRXCR1","9606.ENSP00000294288","9606.ENSP00000382670",0,0,0,0,0,0,0,0.425,0.425]
["CABP2","MYO3A","9606.ENSP00000294288","9606.ENSP00000495965",0,0,0,0,0,0.179,0,0.36,0.452]
["CABP2","OTOG","9606.ENSP00000294288","9606.ENSP00000382323",0,0,0,0,0,0.075,0,0.468,0.487]
["CCDC88C","MPDZ","9606.ENSP00000374507","9606.ENSP00000320006",0,0,0,0,0,0.292,0,0.551,0.668]
["CIB2","USH1C","9606.ENSP00000258930","9606.ENSP00000005226",0,0,0,0,0,0.077,0,0.812,0.819]
["CIB2","TRIOBP","9606.ENSP00000258930","9606.ENSP00000496394",0,0,0,0,0,0,0,0.439,0.439]
["CIB2","NIN","9606.ENSP00000258930","9606.ENSP00000371472",0,0,0,0,0,0.189,0,0.348,0.448]
["CIB2","TPRN","9606.ENSP00000258930","9606.ENSP00000387100",0,0,0,0,0,0.058,0,0.431,0.441]
["CIB2","MYO3A","9606.ENSP00000258930","9606.ENSP00000495965",0,0,0,0,0,0.179,0,0.359,0.452]
["CIB2","MYO6","9606.ENSP00000258930","9606.ENSP00000358994",0,0,0,0,0,0.272,0,0.289,0.46]
["CIB2","CLRN1","9606.ENSP00000258930","9606.ENSP00000329158",0,0,0,0,0,0,0,0.807,0.807]
["CLPP","HARS2","9606.ENSP00000245816","9606.ENSP00000494965",0,0,0,0,0,0.299,0,0.411,0.57]
["CLPP","HSD17B4","9606.ENSP00000245816","9606.ENSP00000411960",0,0,0,0,0,0.166,0,0.677,0.719]
["CLRN1","USH1C","9606.ENSP00000329158","9606.ENSP00000005226",0,0,0,0,0,0,0,0.909,0.909]
["CLRN1","CIB2","9606.ENSP00000329158","9606.ENSP00000258930",0,0,0,0,0,0,0,0.807,0.807]
["CLRN1","SLC17A8","9606.ENSP00000329158","9606.ENSP00000316909",0,0,0,0,0,0,0,0.421,0.421]
["COL9A2","COL9A3","9606.ENSP00000361834","9606.ENSP00000496793",0,0,0,0.882,0,0.9,0.8,0.576,0.99]
["COL9A3","COL9A2","9606.ENSP00000496793","9606.ENSP00000361834",0,0,0,0.882,0,0.9,0.8,0.576,0.99]
["DNASE1","EMB","9606.ENSP00000385905","9606.ENSP00000302289",0,0,0,0,0,0,0,0.454,0.454]
["EMB","DNASE1","9606.ENSP00000302289","9606.ENSP00000385905",0,0,0,0,0,0,0,0.454,0.454]
["EPS8L2","GRXCR1","9606.ENSP00000435585","9606.ENSP00000382670",0,0,0,0,0,0,0.5,0.295,0.632]
["EPS8L2","TPRN","9606.ENSP00000435585","9606.ENSP00000387100",0,0,0,0,0,0,0.5,0.251,0.609]
["EPS8L2","TRIOBP","9606.ENSP00000435585","9606.ENSP00000496394",0,0,0,0,0,0,0.5,0.299,0.634]
["EPS8L2","MYO3A","9606.ENSP00000435585","9606.ENSP00000495965",0,0,0,0,0,0.051,0.8,0.598,0.917]
["GJB3","USH1C","9606.ENSP00000362464","9606.ENSP00000005226",0,0,0,0,0,0,0,0.417,0.416]
["GJB3","MYO6","9606.ENSP00000362464","9606.ENSP00000358994",0,0,0,0,0,0,0,0.45,0.45]
["GJB3","GRXCR1","9606.ENSP00000362464","9606.ENSP00000382670",0,0,0,0,0,0,0,0.431,0.43]
["GJB3","TRIOBP","9606.ENSP00000362464","9606.ENSP00000496394",0,0,0,0,0,0,0,0.445,0.445]
["GJB3","TPRN","9606.ENSP00000362464","9606.ENSP00000387100",0,0,0,0,0,0,0,0.447,0.447]
["GJB3","MYO3A","9606.ENSP00000362464","9606.ENSP00000495965",0,0,0,0,0,0,0,0.474,0.474]
["GJB3","OTOA","9606.ENSP00000362464","9606.ENSP00000496564",0,0,0,0,0,0,0,0.475,0.475]
["GPR152","KLHL18","9606.ENSP00000310255","9606.ENSP00000232766",0,0,0,0,0,0,0,0.427,0.427]
["GPR152","ZCCHC14","9606.ENSP00000310255","9606.ENSP00000268616",0,0,0,0,0,0.069,0,0.407,0.424]
["GRXCR1","USH1C","9606.ENSP00000382670","9606.ENSP00000005226",0,0,0,0,0,0,0,0.777,0.777]
["GRXCR1","CABP2","9606.ENSP00000382670","9606.ENSP00000294288",0,0,0,0,0,0,0,0.425,0.425]
["GRXCR1","MARVELD2","9606.ENSP00000382670","9606.ENSP00000323264",0,0,0,0,0,0,0,0.468,0.468]
["GRXCR1","MYO6","9606.ENSP00000382670","9606.ENSP00000358994",0,0,0,0,0,0,0,0.451,0.451]
["GRXCR1","GJB3","9606.ENSP00000382670","9606.ENSP00000362464",0,0,0,0,0,0,0,0.431,0.43]
["GRXCR1","OTOA","9606.ENSP00000382670","9606.ENSP00000496564",0,0,0,0,0,0,0,0.541,0.541]
["GRXCR1","EPS8L2","9606.ENSP00000382670","9606.ENSP00000435585",0,0,0,0,0,0,0.5,0.295,0.632]
["GRXCR1","TRIOBP","9606.ENSP00000382670","9606.ENSP00000496394",0,0,0,0,0,0,0.5,0.513,0.746]
["GRXCR1","MYO3A","9606.ENSP00000382670","9606.ENSP00000495965",0,0,0,0,0,0,0.5,0.586,0.784]
["GRXCR1","TPRN","9606.ENSP00000382670","9606.ENSP00000387100",0,0,0,0,0,0,0.8,0.656,0.928]
["HARS2","CLPP","9606.ENSP00000494965","9606.ENSP00000245816",0,0,0,0,0,0.299,0,0.411,0.57]
["HARS2","HSD17B4","9606.ENSP00000494965","9606.ENSP00000411960",0,0,0,0,0,0,0,0.422,0.422]
["HSD17B4","CLPP","9606.ENSP00000411960","9606.ENSP00000245816",0,0,0,0,0,0.166,0,0.677,0.719]
["HSD17B4","ACSL4","9606.ENSP00000411960","9606.ENSP00000339787",0,0,0,0,0,0,0.218,0.337,0.459]
["HSD17B4","HARS2","9606.ENSP00000411960","9606.ENSP00000494965",0,0,0,0,0,0,0,0.422,0.422]
["KCNE1","NEDD4L","9606.ENSP00000382226","9606.ENSP00000383199",0,0,0,0,0,0,0,0.616,0.616]
["KLHL18","USH1C","9606.ENSP00000232766","9606.ENSP00000005226",0,0,0,0,0,0.052,0,0.394,0.401]
["KLHL18","TRAM2","9606.ENSP00000232766","9606.ENSP00000182527",0,0,0,0,0,0.053,0,0.434,0.441]
["KLHL18","GPR152","9606.ENSP00000232766","9606.ENSP00000310255",0,0,0,0,0,0,0,0.427,0.427]
["KLHL18","ZCCHC14","9606.ENSP00000232766","9606.ENSP00000268616",0,0,0,0,0,0,0,0.426,0.426]
["MARVELD2","MPDZ","9606.ENSP00000323264","9606.ENSP00000320006",0,0,0,0,0,0,0,0.737,0.737]
["MARVELD2","TRIOBP","9606.ENSP00000323264","9606.ENSP00000496394",0,0,0,0,0,0,0,0.426,0.426]
["MARVELD2","OTOA","9606.ENSP00000323264","9606.ENSP00000496564",0,0,0,0,0,0,0,0.447,0.447]
["MARVELD2","GRXCR1","9606.ENSP00000323264","9606.ENSP00000382670",0,0,0,0,0,0,0,0.468,0.468]
["MPDZ","CCDC88C","9606.ENSP00000320006","9606.ENSP00000374507",0,0,0,0,0,0.292,0,0.551,0.668]
["MPDZ","MARVELD2","9606.ENSP00000320006","9606.ENSP00000323264",0,0,0,0,0,0,0,0.737,0.737]
["MYO3A","USH1C","9606.ENSP00000495965","9606.ENSP00000005226",0,0,0,0,0,0.091,0,0.617,0.637]
["MYO3A","CIB2","9606.ENSP00000495965","9606.ENSP00000258930",0,0,0,0,0,0.179,0,0.359,0.452]
["MYO3A","CABP2","9606.ENSP00000495965","9606.ENSP00000294288",0,0,0,0,0,0.179,0,0.36,0.452]
["MYO3A","MYO6","9606.ENSP00000495965","9606.ENSP00000358994",0,0,0,0.663,0,0.103,0.9,0.34,0.935]
["MYO3A","GJB3","9606.ENSP00000495965","9606.ENSP00000362464",0,0,0,0,0,0,0,0.474,0.474]
["MYO3A","GRXCR1","9606.ENSP00000495965","9606.ENSP00000382670",0,0,0,0,0,0,0.5,0.586,0.784]
["MYO3A","TPRN","9606.ENSP00000495965","9606.ENSP00000387100",0,0,0,0,0,0,0.5,0.559,0.77]
["MYO3A","EPS8L2","9606.ENSP00000495965","9606.ENSP00000435585",0,0,0,0,0,0.051,0.8,0.598,0.917]
["MYO3A","OTOA","9606.ENSP00000495965","9606.ENSP00000496564",0,0,0,0,0,0,0,0.58,0.58]
["MYO3A","TRIOBP","9606.ENSP00000495965","9606.ENSP00000496394",0,0,0,0,0,0,0.5,0.538,0.759]
["MYO6","USH1C","9606.ENSP00000358994","9606.ENSP00000005226",0,0,0,0,0,0,0,0.525,0.525]
["MYO6","OCM","9606.ENSP00000358994","9606.ENSP00000242104",0,0,0,0,0,0.301,0,0.309,0.497]
["MYO6","CIB2","9606.ENSP00000358994","9606.ENSP00000258930",0,0,0,0,0,0.272,0,0.289,0.46]
["MYO6","CABP2","9606.ENSP00000358994","9606.ENSP00000294288",0,0,0,0,0,0.301,0,0.199,0.416]
["MYO6","SLC17A8","9606.ENSP00000358994","9606.ENSP00000316909",0,0,0,0,0,0,0,0.573,0.573]
["MYO6","OTOGL","9606.ENSP00000358994","9606.ENSP00000447211",0,0,0,0,0,0,0,0.42,0.42]
["MYO6","GJB3","9606.ENSP00000358994","9606.ENSP00000362464",0,0,0,0,0,0,0,0.45,0.45]
["MYO6","GRXCR1","9606.ENSP00000358994","9606.ENSP00000382670",0,0,0,0,0,0,0,0.451,0.451]
["MYO6","OTOA","9606.ENSP00000358994","9606.ENSP00000496564",0,0,0,0,0,0,0,0.507,0.507]
["MYO6","TRIOBP","9606.ENSP00000358994","9606.ENSP00000496394",0,0,0,0,0,0,0,0.583,0.583]
["MYO6","OTOG","9606.ENSP00000358994","9606.ENSP00000382323",0,0,0,0,0,0,0,0.595,0.595]
["MYO6","TPRN","9606.ENSP00000358994","9606.ENSP00000387100",0,0,0,0,0,0,0,0.715,0.715]
["MYO6","MYO3A","9606.ENSP00000358994","9606.ENSP00000495965",0,0,0,0.663,0,0.103,0.9,0.34,0.935]
["NEDD4L","UBE2G1","9606.ENSP00000383199","9606.ENSP00000380178",0,0,0,0,0,0.133,0,0.358,0.419]
["NEDD4L","KCNE1","9606.ENSP00000383199","9606.ENSP00000382226",0,0,0,0,0,0,0,0.616,0.616]
["NEDD4L","AAK1","9606.ENSP00000383199","9606.ENSP00000386456",0,0,0,0,0,0,0,0.412,0.412]
["NIN","CIB2","9606.ENSP00000371472","9606.ENSP00000258930",0,0,0,0,0,0.189,0,0.348,0.448]
["NPTN","ATP2B1","9606.ENSP00000290401","9606.ENSP00000392043",0,0,0,0,0,0.36,0,0.619,0.746]
["OCM","SLC17A8","9606.ENSP00000242104","9606.ENSP00000316909",0,0,0,0,0,0.051,0,0.412,0.418]
["OCM","MYO6","9606.ENSP00000242104","9606.ENSP00000358994",0,0,0,0,0,0.301,0,0.309,0.497]
["OTOA","USH1C","9606.ENSP00000496564","9606.ENSP00000005226",0,0,0,0,0,0,0,0.501,0.501]
["OTOA","MARVELD2","9606.ENSP00000496564","9606.ENSP00000323264",0,0,0,0,0,0,0,0.447,0.447]
["OTOA","MYO6","9606.ENSP00000496564","9606.ENSP00000358994",0,0,0,0,0,0,0,0.507,0.507]
["OTOA","GJB3","9606.ENSP00000496564","9606.ENSP00000362464",0,0,0,0,0,0,0,0.475,0.475]
["OTOA","OTOG","9606.ENSP00000496564","9606.ENSP00000382323",0,0,0,0,0,0,0,0.955,0.955]
["OTOA","GRXCR1","9606.ENSP00000496564","9606.ENSP00000382670",0,0,0,0,0,0,0,0.541,0.541]
["OTOA","TPRN","9606.ENSP00000496564","9606.ENSP00000387100",0,0,0,0,0,0,0,0.545,0.545]
["OTOA","MYO3A","9606.ENSP00000496564","9606.ENSP00000495965",0,0,0,0,0,0,0,0.58,0.58]
["OTOA","TRIOBP","9606.ENSP00000496564","9606.ENSP00000496394",0,0,0,0,0,0,0,0.582,0.582]
["OTOG","USH1C","9606.ENSP00000382323","9606.ENSP00000005226",0,0,0,0,0,0.045,0,0.843,0.843]
["OTOG","CABP2","9606.ENSP00000382323","9606.ENSP00000294288",0,0,0,0,0,0.075,0,0.468,0.487]
["OTOG","SLC17A8","9606.ENSP00000382323","9606.ENSP00000316909",0,0,0,0,0,0,0,0.507,0.507]
["OTOG","MYO6","9606.ENSP00000382323","9606.ENSP00000358994",0,0,0,0,0,0,0,0.595,0.595]
["OTOG","OTOGL","9606.ENSP00000382323","9606.ENSP00000447211",0,0,0,0.888,0,0,0.8,0.516,0.899]
["OTOG","OTOA","9606.ENSP00000382323","9606.ENSP00000496564",0,0,0,0,0,0,0,0.955,0.955]
["OTOGL","SLC17A8","9606.ENSP00000447211","9606.ENSP00000316909",0,0,0,0,0,0,0,0.468,0.468]
["OTOGL","MYO6","9606.ENSP00000447211","9606.ENSP00000358994",0,0,0,0,0,0,0,0.42,0.42]
["OTOGL","OTOG","9606.ENSP00000447211","9606.ENSP00000382323",0,0,0,0.888,0,0,0.8,0.516,0.899]
["OTOGL","TPRN","9606.ENSP00000447211","9606.ENSP00000387100",0,0,0,0,0,0,0,0.445,0.445]
["SLC17A8","USH1C","9606.ENSP00000316909","9606.ENSP00000005226",0,0,0,0,0,0,0,0.577,0.577]
["SLC17A8","OCM","9606.ENSP00000316909","9606.ENSP00000242104",0,0,0,0,0,0.051,0,0.412,0.418]
["SLC17A8","CLRN1","9606.ENSP00000316909","9606.ENSP00000329158",0,0,0,0,0,0,0,0.421,0.421]
["SLC17A8","ATP2B1","9606.ENSP00000316909","9606.ENSP00000392043",0,0,0,0,0,0,0,0.46,0.46]
["SLC17A8","OTOGL","9606.ENSP00000316909","9606.ENSP00000447211",0,0,0,0,0,0,0,0.468,0.468]
["SLC17A8","OTOG","9606.ENSP00000316909","9606.ENSP00000382323",0,0,0,0,0,0,0,0.507,0.507]
["SLC17A8","MYO6","9606.ENSP00000316909","9606.ENSP00000358994",0,0,0,0,0,0,0,0.573,0.573]
["TPRN","USH1C","9606.ENSP00000387100","9606.ENSP00000005226",0,0,0,0,0,0.111,0,0.505,0.541]
["TPRN","CIB2","9606.ENSP00000387100","9606.ENSP00000258930",0,0,0,0,0,0.058,0,0.431,0.441]
["TPRN","MYO6","9606.ENSP00000387100","9606.ENSP00000358994",0,0,0,0,0,0,0,0.715,0.715]
["TPRN","GJB3","9606.ENSP00000387100","9606.ENSP00000362464",0,0,0,0,0,0,0,0.447,0.447]
["TPRN","GRXCR1","9606.ENSP00000387100","9606.ENSP00000382670",0,0,0,0,0,0,0.8,0.656,0.928]
["TPRN","OTOGL","9606.ENSP00000387100","9606.ENSP00000447211",0,0,0,0,0,0,0,0.445,0.445]
["TPRN","OTOA","9606.ENSP00000387100","9606.ENSP00000496564",0,0,0,0,0,0,0,0.545,0.545]
["TPRN","EPS8L2","9606.ENSP00000387100","9606.ENSP00000435585",0,0,0,0,0,0,0.5,0.251,0.609]
["TPRN","MYO3A","9606.ENSP00000387100","9606.ENSP00000495965",0,0,0,0,0,0,0.5,0.559,0.77]
["TPRN","TRIOBP","9606.ENSP00000387100","9606.ENSP00000496394",0,0,0,0,0,0,0.5,0.671,0.828]
["TRAM2","ATP2B1","9606.ENSP00000182527","9606.ENSP00000392043",0,0,0,0,0,0,0,0.427,0.426]
["TRAM2","KLHL18","9606.ENSP00000182527","9606.ENSP00000232766",0,0,0,0,0,0.053,0,0.434,0.441]
["TRIOBP","USH1C","9606.ENSP00000496394","9606.ENSP00000005226",0,0,0,0,0,0,0,0.511,0.511]
["TRIOBP","CIB2","9606.ENSP00000496394","9606.ENSP00000258930",0,0,0,0,0,0,0,0.439,0.439]
["TRIOBP","MARVELD2","9606.ENSP00000496394","9606.ENSP00000323264",0,0,0,0,0,0,0,0.426,0.426]
["TRIOBP","MYO6","9606.ENSP00000496394","9606.ENSP00000358994",0,0,0,0,0,0,0,0.583,0.583]
["TRIOBP","GJB3","9606.ENSP00000496394","9606.ENSP00000362464",0,0,0,0,0,0,0,0.445,0.445]
["TRIOBP","GRXCR1","9606.ENSP00000496394","9606.ENSP00000382670",0,0,0,0,0,0,0.5,0.513,0.746]
["TRIOBP","TPRN","9606.ENSP00000496394","9606.ENSP00000387100",0,0,0,0,0,0,0.5,0.671,0.828]
["TRIOBP","EPS8L2","9606.ENSP00000496394","9606.ENSP00000435585",0,0,0,0,0,0,0.5,0.299,0.634]
["TRIOBP","MYO3A","9606.ENSP00000496394","9606.ENSP00000495965",0,0,0,0,0,0,0.5,0.538,0.759]
["TRIOBP","OTOA","9606.ENSP00000496394","9606.ENSP00000496564",0,0,0,0,0,0,0,0.582,0.582]
["UBE2G1","NEDD4L","9606.ENSP00000380178","9606.ENSP00000383199",0,0,0,0,0,0.133,0,0.358,0.419]
["USH1C","KLHL18","9606.ENSP00000005226","9606.ENSP00000232766",0,0,0,0,0,0.052,0,0.394,0.401]
["USH1C","GJB3","9606.ENSP00000005226","9606.ENSP00000362464",0,0,0,0,0,0,0,0.417,0.416]
["USH1C","OTOA","9606.ENSP00000005226","9606.ENSP00000496564",0,0,0,0,0,0,0,0.501,0.501]
["USH1C","TRIOBP","9606.ENSP00000005226","9606.ENSP00000496394",0,0,0,0,0,0,0,0.511,0.511]
["USH1C","MYO6","9606.ENSP00000005226","9606.ENSP00000358994",0,0,0,0,0,0,0,0.525,0.525]
["USH1C","TPRN","9606.ENSP00000005226","9606.ENSP00000387100",0,0,0,0,0,0.111,0,0.505,0.541]
["USH1C","SLC17A8","9606.ENSP00000005226","9606.ENSP00000316909",0,0,0,0,0,0,0,0.577,0.577]
["USH1C","MYO3A","9606.ENSP00000005226","9606.ENSP00000495965",0,0,0,0,0,0.091,0,0.617,0.637]
["USH1C","GRXCR1","9606.ENSP00000005226","9606.ENSP00000382670",0,0,0,0,0,0,0,0.777,0.777]
["USH1C","CIB2","9606.ENSP00000005226","9606.ENSP00000258930",0,0,0,0,0,0.077,0,0.812,0.819]
["USH1C","OTOG","9606.ENSP00000005226","9606.ENSP00000382323",0,0,0,0,0,0.045,0,0.843,0.843]
["USH1C","CLRN1","9606.ENSP00000005226","9606.ENSP00000329158",0,0,0,0,0,0,0,0.909,0.909]
["ZCCHC14","KLHL18","9606.ENSP00000268616","9606.ENSP00000232766",0,0,0,0,0,0,0,0.426,0.426]
["ZCCHC14","GPR152","9606.ENSP00000268616","9606.ENSP00000310255",0,0,0,0,0,0.069,0,0.407,0.424]
["ZCCHC14","ANKRD11","9606.ENSP00000268616","9606.ENSP00000301030",0,0,0,0,0,0.05,0,0.417,0.423]

{"sheet":"Supplementary Table S26.","index":26,"n_rows":13,"n_cols":7,"rows_kept":13}
["Supplementary Table S26. – Human Phenotype Ontology (HPO) Enrichment "]
[]
["Phenotype","Description","Count in Network","Genes","Strength","Signal","False Discovery Rate"]
["HP:0000407","Sensorineural hearing impairment","22 of 753","USH1C, CLPP, CHSY1, CIB2, MPZL2, SLC17A8, MPDZ, MARVELD2, CLRN1, ACSL4, MYO6, COL9A2, GJB3, KCNE1, GRXCR1, TPRN, HSD17B4, HARS2, MYO3A, TRIOBP, OTOA, COL9A3",0.92,1.55,{"v":2.12e-11,"d":"2.12E-11"}]
["HP:0011389","Functional abnormality of the inner ear","23 of 812","USH1C, CLPP, CHSY1, CIB2, MPZL2, SLC17A8, MPDZ, MARVELD2, CLRN1, ACSL4, MYO6, COL9A2, GJB3, KCNE1, GRXCR1, TPRN, HSD17B4, OTOGL, HARS2, MYO3A, TRIOBP, OTOA, COL9A3",0.91,1.54,{"v":1.06e-11,"d":"1.06E-11"}]
["HP:0000365","Hearing impairment","30 of 1288","USH1C, CLPP, CHSY1, CIB2, MPZL2, CABP2, ANKRD11, SLC17A8, MPDZ, MARVELD2, NR2F1, PHF6, CLRN1, ACSL4, MYO6, COL9A2, GJB3, KCNE1, OTOG, GRXCR1, NEDD4L, TPRN, HSD17B4, EPS8L2, OTOGL, HARS2, MYO3A, TRIOBP, OTOA, COL9A3",0.82,1.45,{"v":1.16e-13,"d":"1.16E-13"}]
["HP:0031704","Abnormal ear physiology","30 of 1362","USH1C, CLPP, CHSY1, CIB2, MPZL2, CABP2, ANKRD11, SLC17A8, MPDZ, MARVELD2, NR2F1, PHF6, CLRN1, ACSL4, MYO6, COL9A2, GJB3, KCNE1, OTOG, GRXCR1, NEDD4L, TPRN, HSD17B4, EPS8L2, OTOGL, HARS2, MYO3A, TRIOBP, OTOA, COL9A3",0.8,1.39,{"v":1.75e-13,"d":"1.75E-13"}]
["HP:0001756","Vestibular hypofunction","4 of 12","USH1C, CIB2, CLRN1, OTOGL",1.98,1.1,{"v":0.00036,"d":"3.60E-04"}]
["HP:0000598","Abnormality of the ear","31 of 1919","USH1C, CLPP, CHSY1, CIB2, MPZL2, CABP2, ANKRD11, SLC17A8, MPDZ, MARVELD2, NR2F1, PHF6, CLRN1, ACSL4, MYO6, COL9A2, GJB3, NIN, KCNE1, OTOG, GRXCR1, NEDD4L, TPRN, HSD17B4, EPS8L2, OTOGL, HARS2, MYO3A, TRIOBP, OTOA, COL9A3",0.66,1.05,{"v":9.99e-11,"d":"9.99E-11"}]
["HP:0000408","\t\nProgressive sensorineural hearing impairment","5 of 34","MPZL2, MYO6, GRXCR1, TPRN, MYO3A",1.62,1.05,{"v":0.00036,"d":"3.60E-04"}]
["HP:0001751","\t\nVestibular dysfunction","6 of 101","USH1C, CIB2, CLRN1, MYO6, GJB3, OTOGL",1.23,0.76,{"v":0.0022,"d":"2.20E-03"}]
["HP:0030973","\t\nPostexertional symptom exacerbation","3 of 13","COL9A2, KCNE1, COL9A3",1.82,0.53,{"v":0.0224,"d":"2.24E-02"}]
["HP:0000118","\t\nPhenotypic abnormality","41 of 5129\t","SEMA3F, USH1C, CLPP, CHSY1, CIB2, ELMOD1, ZCCHC14, MPZL2, CABP2, ANKRD11, REST, SLC17A8, MPDZ, MARVELD2, NR2F1, PHF6, CLRN1, ACSL4, IKZF5, MYO6, COL9A2, GJB3, NIN, CCDC88C, KCNE1, OTOG, GRXCR1, NEDD4L, DNASE1, TPRN, KLC2, EWSR1, HSD17B4, NISCH, EPS8L2, OTOGL, HARS2, MYO3A, TRIOBP, OTOA, COL9A3",0.36,0.52,{"v":9.62e-06,"d":"9.62E-06"}]

{"sheet":"Supplementary Table S27. ","index":27,"n_rows":77,"n_cols":13,"rows_kept":77}
["Supplementary Table S27. – Protein-Protein Interaction Networks According to STRING in Mus musculus. "]
[]
["#node1","node2","node1_string_id","node2_string_id","neighborhood_on_chromosome","gene_fusion","phylogenetic_cooccurrence","homology","coexpression","experimentally_determined_interaction","database_annotated","automated_textmining","combined_score"]
["Aak1","Baiap2l2","10090.ENSMUSP00000086948","10090.ENSMUSP00000127816",0,0,0,0,0,0,0.72,0,0.72]
["Ankrd11","Wdtc1","10090.ENSMUSP00000095939","10090.ENSMUSP00000040647",0,0,0,0,0,0,0,0.443,0.443]
["Ap3m2","Ap3s1","10090.ENSMUSP00000128446","10090.ENSMUSP00000025357",0,0,0,0,0,0.628,0.9,0.423,0.976]
["Baiap2l2","Tprn","10090.ENSMUSP00000127816","10090.ENSMUSP00000109975",0,0,0,0,0,0,0,0.416,0.416]
["Cabp2","Myo6","10090.ENSMUSP00000125255","10090.ENSMUSP00000036181",0,0,0,0,0,0.295,0,0.208,0.417]
["Cabp2","Otoa","10090.ENSMUSP00000125255","10090.ENSMUSP00000044177",0,0,0,0,0,0.111,0,0.452,0.492]
["Cabp2","Myo3a","10090.ENSMUSP00000125255","10090.ENSMUSP00000046329",0,0,0,0,0,0.261,0,0.367,0.512]
["Cabp2","Grxcr1","10090.ENSMUSP00000125255","10090.ENSMUSP00000092305",0,0,0,0,0,0,0,0.477,0.477]
["Cabp2","Otog","10090.ENSMUSP00000125255","10090.ENSMUSP00000130949",0,0,0,0,0,0.072,0,0.425,0.444]
["Ccdc88c","Mpdz","10090.ENSMUSP00000068629","10090.ENSMUSP00000099894",0,0,0,0,0,0.093,0,0.606,0.627]
["Cib2","Ush1c","10090.ENSMUSP00000038527","10090.ENSMUSP00000009667",0,0,0,0,0,0,0,0.76,0.76]
["Cib2","Myo6","10090.ENSMUSP00000038527","10090.ENSMUSP00000036181",0,0,0,0,0,0.262,0,0.314,0.472]
["Cib2","Tprn","10090.ENSMUSP00000038527","10090.ENSMUSP00000109975",0,0,0,0,0,0,0,0.449,0.449]
["Cib2","Triobp","10090.ENSMUSP00000038527","10090.ENSMUSP00000105312",0,0,0,0,0,0,0,0.453,0.453]
["Cib2","Nin","10090.ENSMUSP00000038527","10090.ENSMUSP00000152240",0,0,0,0,0,0.223,0,0.346,0.47]
["Cib2","Myo3a","10090.ENSMUSP00000038527","10090.ENSMUSP00000046329",0,0,0,0,0,0.224,0,0.4,0.514]
["Cib2","Clrn1","10090.ENSMUSP00000038527","10090.ENSMUSP00000052254",0,0,0,0,0,0,0,0.78,0.78]
["Clpp","Hars2","10090.ENSMUSP00000002735","10090.ENSMUSP00000117231",0,0,0,0,0,0.094,0,0.416,0.448]
["Clpp","Hsd17b4","10090.ENSMUSP00000002735","10090.ENSMUSP00000025385",0,0,0,0,0,0.072,0,0.522,0.538]
["Clrn1","Ush1c","10090.ENSMUSP00000052254","10090.ENSMUSP00000009667",0,0,0,0,0,0,0,0.867,0.867]
["Clrn1","Slc17a8","10090.ENSMUSP00000052254","10090.ENSMUSP00000020102",0,0,0,0,0,0,0,0.433,0.433]
["Clrn1","Hars2","10090.ENSMUSP00000052254","10090.ENSMUSP00000117231",0,0,0,0,0,0,0,0.408,0.408]
["Col9a2","Col9a3","10090.ENSMUSP00000030372","10090.ENSMUSP00000128718",0,0,0,0.876,0,0.747,0.8,0.472,0.97]
["Eps8l2","Tprn","10090.ENSMUSP00000026577","10090.ENSMUSP00000109975",0,0,0,0,0,0,0.5,0.3,0.635]
["Eps8l2","Grxcr1","10090.ENSMUSP00000026577","10090.ENSMUSP00000092305",0,0,0,0,0,0,0.5,0.355,0.663]
["Eps8l2","Triobp","10090.ENSMUSP00000026577","10090.ENSMUSP00000105312",0,0,0,0,0,0,0.5,0.341,0.656]
["Eps8l2","Myo3a","10090.ENSMUSP00000026577","10090.ENSMUSP00000046329",0,0,0,0,0,0,0.8,0.66,0.929]
["Gpr152","Zcchc14","10090.ENSMUSP00000094062","10090.ENSMUSP00000040360",0,0,0,0,0,0.087,0,0.479,0.504]
["Gpr152","Zfp719","10090.ENSMUSP00000094062","10090.ENSMUSP00000050968",0,0,0,0,0,0.094,0,0.517,0.543]
["Gpr152","Klhl18","10090.ENSMUSP00000094062","10090.ENSMUSP00000069674",0,0,0,0,0,0,0,0.483,0.483]
["Gpr152","Minar2","10090.ENSMUSP00000094062","10090.ENSMUSP00000125952",0,0,0,0,0,0,0,0.578,0.578]
["Grxcr1","Ush1c","10090.ENSMUSP00000092305","10090.ENSMUSP00000009667",0,0,0,0,0,0,0,0.769,0.769]
["Grxcr1","Myo6","10090.ENSMUSP00000092305","10090.ENSMUSP00000036181",0,0,0,0,0,0,0,0.403,0.403]
["Grxcr1","Myo3a","10090.ENSMUSP00000092305","10090.ENSMUSP00000046329",0,0,0,0,0,0,0.5,0.61,0.797]
["Grxcr1","Triobp","10090.ENSMUSP00000092305","10090.ENSMUSP00000105312",0,0,0,0,0,0,0.5,0.433,0.704]
["Grxcr1","Tprn","10090.ENSMUSP00000092305","10090.ENSMUSP00000109975",0,0,0,0,0,0,0.8,0.66,0.929]
["Hsd17b4","Tprn","10090.ENSMUSP00000025385","10090.ENSMUSP00000109975",0,0,0,0,0,0,0,0.429,0.429]
["Kcne1","Nedd4l","10090.ENSMUSP00000052248","10090.ENSMUSP00000158026",0,0,0,0,0,0,0,0.598,0.598]
["Klhl18","Zcchc14","10090.ENSMUSP00000069674","10090.ENSMUSP00000040360",0,0,0,0,0,0,0,0.466,0.466]
["Klhl18","Tram2","10090.ENSMUSP00000069674","10090.ENSMUSP00000047992",0,0,0,0,0,0.042,0,0.422,0.423]
["Klhl18","Zfp719","10090.ENSMUSP00000069674","10090.ENSMUSP00000050968",0,0,0,0,0,0.054,0,0.489,0.495]
["Klhl18","Minar2","10090.ENSMUSP00000069674","10090.ENSMUSP00000125952",0,0,0,0,0,0,0,0.52,0.52]
["Marveld2","Mpdz","10090.ENSMUSP00000153294","10090.ENSMUSP00000099894",0,0,0,0,0,0,0,0.51,0.51]
["Minar2","Zcchc14","10090.ENSMUSP00000125952","10090.ENSMUSP00000040360",0,0,0,0,0,0,0,0.48,0.48]
["Minar2","Tram2","10090.ENSMUSP00000125952","10090.ENSMUSP00000047992",0,0,0,0,0,0,0,0.456,0.456]
["Minar2","Zfp719","10090.ENSMUSP00000125952","10090.ENSMUSP00000050968",0,0,0,0,0,0,0,0.766,0.766]
["Myo3a","Ush1c","10090.ENSMUSP00000046329","10090.ENSMUSP00000009667",0,0,0,0,0,0.08,0,0.599,0.615]
["Myo3a","Ocm","10090.ENSMUSP00000046329","10090.ENSMUSP00000031622",0,0,0,0,0,0.261,0,0.294,0.456]
["Myo3a","Myo6","10090.ENSMUSP00000046329","10090.ENSMUSP00000036181",0,0,0,0.661,0,0.322,0.72,0.29,0.853]
["Myo3a","Triobp","10090.ENSMUSP00000046329","10090.ENSMUSP00000105312",0,0,0,0,0,0,0.5,0.515,0.747]
["Myo3a","Tprn","10090.ENSMUSP00000046329","10090.ENSMUSP00000109975",0,0,0,0,0,0,0.5,0.557,0.769]
["Myo6","Ush1c","10090.ENSMUSP00000036181","10090.ENSMUSP00000009667",0,0,0,0,0,0,0,0.421,0.421]
["Myo6","Slc17a8","10090.ENSMUSP00000036181","10090.ENSMUSP00000020102",0,0,0,0,0,0,0,0.667,0.667]
["Myo6","Ocm","10090.ENSMUSP00000036181","10090.ENSMUSP00000031622",0,0,0,0,0,0.295,0,0.36,0.529]
["Myo6","Otogl","10090.ENSMUSP00000036181","10090.ENSMUSP00000129467",0,0,0,0,0,0.095,0,0.389,0.423]
["Myo6","Triobp","10090.ENSMUSP00000036181","10090.ENSMUSP00000105312",0,0,0,0,0,0,0,0.553,0.553]
["Myo6","Otog","10090.ENSMUSP00000036181","10090.ENSMUSP00000130949",0,0,0,0,0,0.095,0,0.601,0.624]
["Myo6","Tprn","10090.ENSMUSP00000036181","10090.ENSMUSP00000109975",0,0,0,0,0,0,0,0.714,0.714]
["Nedd4l","Ube2g1","10090.ENSMUSP00000158026","10090.ENSMUSP00000021148",0,0,0,0,0,0.146,0,0.347,0.418]
["Ocm","Slc17a8","10090.ENSMUSP00000031622","10090.ENSMUSP00000020102",0,0,0,0,0,0.063,0,0.42,0.433]
["Otoa","Otogl","10090.ENSMUSP00000044177","10090.ENSMUSP00000129467",0,0,0,0,0,0.089,0,0.651,0.668]
["Otoa","Otog","10090.ENSMUSP00000044177","10090.ENSMUSP00000130949",0,0,0,0,0,0.089,0,0.696,0.712]
["Otog","Ush1c","10090.ENSMUSP00000130949","10090.ENSMUSP00000009667",0,0,0,0,0,0.051,0,0.468,0.473]
["Otog","Slc17a8","10090.ENSMUSP00000130949","10090.ENSMUSP00000020102",0,0,0,0,0,0,0,0.457,0.457]
["Otog","Otogl","10090.ENSMUSP00000130949","10090.ENSMUSP00000129467",0,0,0,0.89,0,0,0.8,0.518,0.899]
["Otogl","Slc17a8","10090.ENSMUSP00000129467","10090.ENSMUSP00000020102",0,0,0,0,0,0,0,0.425,0.425]
["Otogl","Tprn","10090.ENSMUSP00000129467","10090.ENSMUSP00000109975",0,0,0,0,0,0,0,0.44,0.44]
["Slc17a8","Ush1c","10090.ENSMUSP00000020102","10090.ENSMUSP00000009667",0,0,0,0,0,0,0,0.561,0.561]
["Tprn","Ush1c","10090.ENSMUSP00000109975","10090.ENSMUSP00000009667",0,0,0,0,0,0,0,0.405,0.405]
["Tprn","Triobp","10090.ENSMUSP00000109975","10090.ENSMUSP00000105312",0,0,0,0,0,0,0.5,0.706,0.846]
["Tram2","Zfp719","10090.ENSMUSP00000047992","10090.ENSMUSP00000050968",0,0,0,0,0,0,0,0.41,0.41]
["Triobp","Ush1c","10090.ENSMUSP00000105312","10090.ENSMUSP00000009667",0,0,0,0,0,0,0,0.425,0.425]
["Ube2b","Ube2g1","10090.ENSMUSP00000020657","10090.ENSMUSP00000021148",0,0,0,0.859,0,0.062,0.5,0.212,0.598]
["Zcchc14","Zfp719","10090.ENSMUSP00000040360","10090.ENSMUSP00000050968",0,0,0,0,0,0.069,0,0.432,0.448]