{"text_format":"3","workbook":"xls","n_sheets":8,"sheets":["Descriptions","Supplementary Table 1","Supplementary Table 2","Supplementary Table 3","Supplementary Table 4","Supplementary Table 5","Supplementary Table 6","TableS7"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Descriptions","index":0,"n_rows":6,"n_cols":1,"rows_kept":6,"flags":["formulas_cached_only"]}
["Supplementary Table 1. GO biological processes that are enriched for HepScope gene set and its treemap classification. "]
["Supplementary Table 2. KEGG pathways that are enriched for HepScope gene set. "]
["Supplementary Table 3. Ranks of genes in HepScope gene set based on Log2FC. "]
["Supplementary Table 4. Description of RNA-seq datasets. "]
["Supplementary Table 5. Description of stRNA-seq datasets. "]
["Supplementary Table 6. Description of the 5 publicly available HCC related gene set used in this study. "]

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["Supplementary Table 1. GO biological processes that are enriched for HepScope gene set and its treemap classification. "]
["GO ID","GO Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Tree map cluster","Tree Map cluster GO ID","parentSimScore","Treep Map cluster description"]
["GO:0006119","oxidative phosphorylation","13/107","110/16199",{"v":3.36069835315449e-13,"d":"3.36E-13"},{"v":8.3446140108826e-10,"d":"8.34E-10"},{"v":6.49852934183663e-10,"d":"6.50E-10"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/NUPR1/COX5B/NDUFA13/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.998,"oxidative phosphorylation"]
["GO:0042773","ATP synthesis coupled electron transport","11/107","82/16199",{"v":5.8536971757124e-12,"d":"5.85E-12"},{"v":3.95937232443308e-09,"d":"3.96E-09"},{"v":3.08343767513135e-09,"d":"3.08E-09"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/COX5B/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.96,"oxidative phosphorylation"]
["GO:0042775","mitochondrial ATP synthesis coupled electron transport","11/107","82/16199",{"v":5.8536971757124e-12,"d":"5.85E-12"},{"v":3.95937232443308e-09,"d":"3.96E-09"},{"v":3.08343767513135e-09,"d":"3.08E-09"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/COX5B/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.958,"oxidative phosphorylation"]
["GO:0006457","protein folding","15/107","207/16199",{"v":6.37836862574802e-12,"d":"6.38E-12"},{"v":3.95937232443308e-09,"d":"3.96E-09"},{"v":3.08343767513135e-09,"d":"3.08E-09"},"HSPA1A/HSPB1/HSP90AB1/HSP90AA1/PPIA/HSPA1B/HSPE1/PPIB/B2M/CALR/PTGES3/HSPA8/CCT3/DNAJB1/HSPD1",2,"GO:0006457",0.998,"protein folding"]
["GO:0006123","mitochondrial electron transport, cytochrome c to oxygen","7/107","18/16199",{"v":1.3479998136588e-11,"d":"1.35E-11"},{"v":6.6941670746296e-09,"d":"6.69E-09"},{"v":5.21321191092887e-09,"d":"5.21E-09"},"COX6A1/NDUFA4/COX6C/COX6B1/COX5B/COX4I1/COX8A",1,"GO:0006119",0.862,"oxidative phosphorylation"]
["GO:0009060","aerobic respiration","13/107","156/16199",{"v":3.07389739690772e-11,"d":"3.07E-11"},{"v":1.27208120608698e-08,"d":"1.27E-08"},{"v":9.90657810196402e-09,"d":"9.91E-09"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/NUPR1/COX5B/NDUFA13/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.963,"oxidative phosphorylation"]
["GO:0019646","aerobic electron transport chain","10/107","75/16199",{"v":5.97228703773094e-11,"d":"5.97E-11"},{"v":1.8590927308325e-08,"d":"1.86E-08"},{"v":1.44780437354614e-08,"d":"1.45E-08"},"COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/COX5B/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.951,"oxidative phosphorylation"]
["GO:0022904","respiratory electron transport chain","11/107","101/16199",{"v":5.98982756611358e-11,"d":"5.99E-11"},{"v":1.8590927308325e-08,"d":"1.86E-08"},{"v":1.44780437354614e-08,"d":"1.45E-08"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/COX5B/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.877,"oxidative phosphorylation"]
["GO:0042026","protein refolding","7/107","26/16199",{"v":2.66815909037053e-10,"d":"2.67E-10"},{"v":7.36115446821114e-08,"d":"7.36E-08"},{"v":5.73264122691305e-08,"d":"5.73E-08"},"HSPA1A/HSPB1/HSP90AA1/HSPA1B/B2M/HSPA8/HSPD1",2,"GO:0006457",0.845,"protein folding"]
["GO:0045333","cellular respiration","13/107","199/16199",{"v":6.45652508315725e-10,"d":"6.46E-10"},{"v":1.56490115972205e-07,"d":"1.56E-07"},{"v":1.21869700507002e-07,"d":"1.22E-07"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/NUPR1/COX5B/NDUFA13/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.946,"oxidative phosphorylation"]
["GO:0061077","chaperone-mediated protein folding","9/107","69/16199",{"v":6.93270751387137e-10,"d":"6.93E-10"},{"v":1.56490115972205e-07,"d":"1.56E-07"},{"v":1.21869700507002e-07,"d":"1.22E-07"},"HSPA1A/HSPB1/HSPA1B/HSPE1/PPIB/PTGES3/HSPA8/CCT3/DNAJB1",2,"GO:0006457",0.892,"protein folding"]
["GO:0015980","energy derivation by oxidation of organic compounds","14/107","283/16199",{"v":5.09051142123176e-09,"d":"5.09E-09"},{"v":9.51092573847841e-07,"d":"9.51E-07"},{"v":7.40681712766172e-07,"d":"7.41E-07"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/NUPR1/PTGES3/COX5B/NDUFA13/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.921,"oxidative phosphorylation"]
["GO:0022900","electron transport chain","11/107","153/16199",{"v":5.29021532359191e-09,"d":"5.29E-09"},{"v":9.51092573847841e-07,"d":"9.51E-07"},{"v":7.40681712766172e-07,"d":"7.41E-07"},"COX6A1/CHCHD2/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/COX5B/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.79,"oxidative phosphorylation"]
["GO:0050821","protein stabilization","12/107","193/16199",{"v":5.36258398464349e-09,"d":"5.36E-09"},{"v":9.51092573847841e-07,"d":"9.51E-07"},{"v":7.40681712766172e-07,"d":"7.41E-07"},"HSPA1A/APOA2/HSP90AB1/GAPDH/HSP90AA1/HSPA1B/PPIB/NPM1/CALR/PTGES3/CCT3/HSPD1",3,"GO:0050821",0.998,"protein stabilization"]
["GO:0006458","'de novo' protein folding","7/107","39/16199",{"v":5.81478177583821e-09,"d":"5.81E-09"},{"v":9.62540209960418e-07,"d":"9.63E-07"},{"v":7.49596780506301e-07,"d":"7.50E-07"},"HSPA1A/HSPA1B/HSPE1/PTGES3/HSPA8/DNAJB1/HSPD1",2,"GO:0006457",0.856,"protein folding"]
["GO:0044403","biological process involved in symbiotic interaction","14/107","296/16199",{"v":9.02698953976069e-09,"d":"9.03E-09"},{"v":1.37620979288685e-06,"d":"1.38E-06"},{"v":1.07174995846838e-06,"d":"1.07E-06"},"HSPA1A/HSP90AB1/GAPDH/APOE/EEF1A1/PPIA/IFI27/HSPA1B/IFITM3/PPIB/CFL1/HSPA8/CFHR1/HSPD1",4,"GO:0044403",0.997,"biological process involved in symbiotic interaction"]
["GO:0031647","regulation of protein stability","14/107","297/16199",{"v":9.42229821952333e-09,"d":"9.42E-09"},{"v":1.37620979288685e-06,"d":"1.38E-06"},{"v":1.07174995846838e-06,"d":"1.07E-06"},"HSPA1A/APOA2/HSP90AB1/GAPDH/HSP90AA1/HSPA1B/SERF2/PPIB/NPM1/CALR/PTGES3/HSPA8/CCT3/HSPD1",3,"GO:0050821",0.961,"protein stabilization"]
["GO:1902600","proton transmembrane transport","10/107","128/16199",{"v":1.22329555824535e-08,"d":"1.22E-08"},{"v":1.68746826173512e-06,"d":"1.69E-06"},{"v":1.31414850321445e-06,"d":"1.31E-06"},"COX6A1/TMSB4X/NDUFA4/COX6B1/SLC25A5/COX5B/SLC25A3/UQCRH/COX4I1/COX8A",5,"GO:1902600",0.999,"proton transmembrane transport"]
["GO:0006986","response to unfolded protein","10/107","136/16199",{"v":2.19412989823357e-08,"d":"2.19E-08"},{"v":2.8673813354284e-06,"d":"2.87E-06"},{"v":2.23302860003051e-06,"d":"2.23E-06"},"HSPA1A/HSPB1/HSP90AB1/HSP90AA1/HSPA1B/HSPE1/RACK1/HSPA8/DNAJB1/HSPD1",6,"GO:0006986",0.999,"response to unfolded protein"]
["GO:0006091","generation of precursor metabolites and energy","16/107","449/16199",{"v":3.98871699693773e-08,"d":"3.99E-08"},{"v":4.9519921516982e-06,"d":"4.95E-06"},{"v":3.85645953861822e-06,"d":"3.86E-06"},"GAPDH/COX6A1/CHCHD2/NDUFC2/NDUFA4/TPI1/COX6C/UQCRB/COX6B1/NUPR1/PTGES3/COX5B/NDUFA13/UQCRH/COX4I1/COX8A",1,"GO:0006119",0.883,"oxidative phosphorylation"]
["GO:0051702","biological process involved in interaction with symbiont","9/107","109/16199",{"v":4.19185941034905e-08,"d":"4.19E-08"},{"v":4.95637472185557e-06,"d":"4.96E-06"},{"v":3.85987254978006e-06,"d":"3.86E-06"},"GAPDH/APOE/EEF1A1/IFI27/PPIB/CFL1/HSPA8/CFHR1/HSPD1",4,"GO:0044403",0.916,"biological process involved in symbiotic interaction"]
["GO:0051085","chaperone cofactor-dependent protein refolding","6/107","31/16199",{"v":4.64200884082172e-08,"d":"4.64E-08"},{"v":5.23913997807288e-06,"d":"5.24E-06"},{"v":4.08008145482751e-06,"d":"4.08E-06"},"HSPA1A/HSPA1B/HSPE1/PTGES3/HSPA8/DNAJB1",2,"GO:0006457",0.84,"protein folding"]
["GO:0035966","response to topologically incorrect protein","10/107","157/16199",{"v":8.61195567661597e-08,"d":"8.61E-08"},{"v":9.29716780219019e-06,"d":"9.30E-06"},{"v":7.24034900592381e-06,"d":"7.24E-06"},"HSPA1A/HSPB1/HSP90AB1/HSP90AA1/HSPA1B/HSPE1/RACK1/HSPA8/DNAJB1/HSPD1",6,"GO:0006986",0.988,"response to unfolded protein"]
["GO:0009205","purine ribonucleoside triphosphate metabolic process","11/107","202/16199",{"v":9.41659011080595e-08,"d":"9.42E-08"},{"v":9.74224718547132e-06,"d":"9.74E-06"},{"v":7.58696317260988e-06,"d":"7.59E-06"},"HSPA1A/GAPDH/HSPA1B/TMSB4X/NDUFC2/NME2/TPI1/NUPR1/HSPA8/NDUFA13/RAN",7,"GO:0009205",0.998,"purine ribonucleoside triphosphate metabolic process"]
["GO:0051084","'de novo' post-translational protein folding","6/107","35/16199",{"v":1.0016736051788e-07,"d":"1.00E-07"},{"v":9.94862224663587e-06,"d":"9.95E-06"},{"v":7.74768173774089e-06,"d":"7.75E-06"},"HSPA1A/HSPA1B/HSPE1/PTGES3/HSPA8/DNAJB1",2,"GO:0006457",0.848,"protein folding"]
["GO:0009144","purine nucleoside triphosphate metabolic process","11/107","207/16199",{"v":1.20722599843687e-07,"d":"1.21E-07"},{"v":1.15290082850721e-05,"d":"1.15E-05"},{"v":8.97843789120864e-06,"d":"8.98E-06"},"HSPA1A/GAPDH/HSPA1B/TMSB4X/NDUFC2/NME2/TPI1/NUPR1/HSPA8/NDUFA13/RAN",7,"GO:0009205",0.995,"purine ribonucleoside triphosphate metabolic process"]
["GO:0009199","ribonucleoside triphosphate metabolic process","11/107","209/16199",{"v":1.33081560515802e-07,"d":"1.33E-07"},{"v":1.2238574620768e-05,"d":"1.22E-05"},{"v":9.53102638080034e-06,"d":"9.53E-06"},"HSPA1A/GAPDH/HSPA1B/TMSB4X/NDUFC2/NME2/TPI1/NUPR1/HSPA8/NDUFA13/RAN",7,"GO:0009205",0.99,"purine ribonucleoside triphosphate metabolic process"]
["GO:0044794","positive regulation by host of viral process","5/107","20/16199",{"v":1.63968648739102e-07,"d":"1.64E-07"},{"v":1.45405055292568e-05,"d":"1.45E-05"},{"v":1.13236995388621e-05,"d":"1.13E-05"},"APOE/EEF1A1/PPIB/CFL1/HSPA8",4,"GO:0044403",0.8,"biological process involved in symbiotic interaction"]
["GO:0051131","chaperone-mediated protein complex assembly","5/107","22/16199",{"v":2.75594049904139e-07,"d":"2.76E-07"},{"v":2.35965526176544e-05,"d":"2.36E-05"},{"v":1.83762711315391e-05,"d":"1.84E-05"},"HSPA1A/HSP90AB1/HSP90AA1/PTGES3/HSPD1",8,"GO:0051131",1,"chaperone-mediated protein complex assembly"]
["GO:0009141","nucleoside triphosphate metabolic process","11/107","226/16199",{"v":2.92560740243827e-07,"d":"2.93E-07"},{"v":2.42142772675141e-05,"d":"2.42E-05"},{"v":1.88573361343126e-05,"d":"1.89E-05"},"HSPA1A/GAPDH/HSPA1B/TMSB4X/NDUFC2/NME2/TPI1/NUPR1/HSPA8/NDUFA13/RAN",7,"GO:0009205",0.98,"purine ribonucleoside triphosphate metabolic process"]
["GO:0044788","modulation by host of viral process","6/107","42/16199",{"v":3.11824668778304e-07,"d":"3.12E-07"},{"v":2.49761500831138e-05,"d":"2.50E-05"},{"v":1.94506593054582e-05,"d":"1.95E-05"},"APOE/EEF1A1/IFI27/PPIB/CFL1/HSPA8",4,"GO:0044403",0.854,"biological process involved in symbiotic interaction"]
["GO:2001242","regulation of intrinsic apoptotic signaling pathway","9/107","153/16199",{"v":7.70235831212028e-07,"d":"7.70E-07"},{"v":5.97654865281083e-05,"d":"5.98E-05"},{"v":4.65435270373847e-05,"d":"4.65E-05"},"HSPA1A/HSPB1/PPIA/UBB/RACK1/TPT1/NUPR1/MIF/NDUFA13",9,"GO:2001242",0.999,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0033700","phospholipid efflux","4/107","13/16199",{"v":1.22885718876395e-06,"d":"1.23E-06"},{"v":9.24621939303297e-05,"d":"9.25E-05"},{"v":7.20067194819576e-05,"d":"7.20E-05"},"APOA2/APOE/APOC2/APOC1",10,"GO:0033700",1,"phospholipid efflux"]
["GO:0009150","purine ribonucleotide metabolic process","13/107","399/16199",{"v":2.25130366777026e-06,"d":"2.25E-06"},0.000164411382560987,0.000128038539866686,"HSPA1A/GAPDH/MPC2/HSPA1B/TMSB4X/NDUFC2/NME2/HINT1/TPI1/NUPR1/HSPA8/NDUFA13/RAN",11,"GO:0009150",0.995,"purine ribonucleotide metabolic process"]
["GO:0046034","ATP metabolic process","9/107","178/16199",{"v":2.71501475432034e-06,"d":"2.72E-06"},0.000192610903856497,0.000149999461765007,"HSPA1A/GAPDH/HSPA1B/TMSB4X/NDUFC2/TPI1/NUPR1/HSPA8/NDUFA13",7,"GO:0009205",0.991,"purine ribonucleoside triphosphate metabolic process"]
["GO:0042176","regulation of protein catabolic process","12/107","345/16199",{"v":2.90740969677698e-06,"d":"2.91E-06"},0.000200530507697145,0.000156167006227465,"HSPA1A/HSP90AB1/APOE/HSP90AA1/EEF1A1/UBB/HSPA1B/GPC3/RACK1/SUMO2/NUPR1/NDUFA13",12,"GO:0042176",0.997,"regulation of protein catabolic process"]
["GO:0009259","ribonucleotide metabolic process","13/107","418/16199",{"v":3.74933537474083e-06,"d":"3.75E-06"},0.000251610803661662,0.000195946773354165,"HSPA1A/GAPDH/MPC2/HSPA1B/TMSB4X/NDUFC2/NME2/HINT1/TPI1/NUPR1/HSPA8/NDUFA13/RAN",7,"GO:0009205",0.849,"purine ribonucleoside triphosphate metabolic process"]
["GO:0051098","regulation of binding","12/107","356/16199",{"v":4.01398350923229e-06,"d":"4.01E-06"},0.000262282132984836,0.00020425727718725,"HSP90AB1/APOE/S100A10/ACTB/TXN/TMSB4X/RACK1/B2M/VTN/CALM2/RAN/CFHR1",13,"GO:0051098",0.997,"regulation of binding"]
["GO:1990748","cellular detoxification","7/107","100/16199",{"v":4.35148948074653e-06,"d":"4.35E-06"},0.000277044830274195,0.000215754012851049,"APOE/TXN/PRDX1/GSTA1/GPX4/PRDX5/ALDH1A1",14,"GO:1990748",0.999,"cellular detoxification"]
["GO:0019693","ribose phosphate metabolic process","13/107","427/16199",{"v":4.72733018647924e-06,"d":"4.73E-06"},0.000286291728122633,0.000222955213159496,"HSPA1A/GAPDH/MPC2/HSPA1B/TMSB4X/NDUFC2/NME2/HINT1/TPI1/NUPR1/HSPA8/NDUFA13/RAN",7,"GO:0009205",0.733,"purine ribonucleoside triphosphate metabolic process"]
["GO:0006163","purine nucleotide metabolic process","13/107","427/16199",{"v":4.72733018647924e-06,"d":"4.73E-06"},0.000286291728122633,0.000222955213159496,"HSPA1A/GAPDH/MPC2/HSPA1B/TMSB4X/NDUFC2/NME2/HINT1/TPI1/NUPR1/HSPA8/NDUFA13/RAN",11,"GO:0009150",0.986,"purine ribonucleotide metabolic process"]
["GO:0044827","modulation by host of viral genome replication","4/107","19/16199",{"v":6.46118527821155e-06,"d":"6.46E-06"},0.000381979120138078,0.000297473617946732,"EEF1A1/IFI27/PPIB/HSPA8",4,"GO:0044403",0.81,"biological process involved in symbiotic interaction"]
["GO:0097237","cellular response to toxic substance","7/107","107/16199",{"v":6.82555774255299e-06,"d":"6.83E-06"},0.000394136276157188,0.000306941238018846,"APOE/TXN/PRDX1/GSTA1/GPX4/PRDX5/ALDH1A1",14,"GO:1990748",0.995,"cellular detoxification"]
["GO:0070527","platelet aggregation","6/107","71/16199",{"v":7.29113145516383e-06,"d":"7.29E-06"},0.000411451804617541,0.000320426040266411,"HSPB1/PPIA/ACTB/ACTG1/MYL12A/CLIC1",15,"GO:0070527",0.999,"platelet aggregation"]
["GO:0045732","positive regulation of protein catabolic process","9/107","202/16199",{"v":7.62119771111852e-06,"d":"7.62E-06"},0.000420520753704607,0.00032748865953976,"HSPA1A/APOE/HSP90AA1/HSPA1B/GPC3/RACK1/SUMO2/NUPR1/NDUFA13",12,"GO:0042176",0.949,"regulation of protein catabolic process"]
["GO:0072521","purine-containing compound metabolic process","13/107","454/16199",{"v":9.1519255362739e-06,"d":"9.15E-06"},0.000494005024055828,0.000384715954465335,"HSPA1A/GAPDH/MPC2/HSPA1B/TMSB4X/NDUFC2/NME2/HINT1/TPI1/NUPR1/HSPA8/NDUFA13/RAN",11,"GO:0009150",0.976,"purine ribonucleotide metabolic process"]
["GO:0034599","cellular response to oxidative stress","10/107","263/16199",{"v":9.45709828381034e-06,"d":"9.46E-06"},0.000499616490185129,0.000389085992102119,"HSPA1A/HSPB1/AKR1C3/PPIA/TXN/PRDX1/HSPA1B/CHCHD2/RACK1/PRDX5",6,"GO:0006986",0.407,"response to unfolded protein"]
["GO:0006979","response to oxidative stress","12/107","401/16199",{"v":1.33724555269275e-05,"d":"1.34E-05"},0.00069174598069502,0.000538710543924688,"HSPA1A/HSPB1/APOE/AKR1C3/PPIA/TXN/PRDX1/HSPA1B/CHCHD2/RACK1/GPX4/PRDX5",6,"GO:0006986",0.422,"response to unfolded protein"]
["GO:0051851","modulation by host of symbiont process","6/107","80/16199",{"v":1.45806716060943e-05,"d":"1.46E-05"},0.000696227069191004,0.000542200278145653,"APOE/EEF1A1/IFI27/PPIB/CFL1/HSPA8",4,"GO:0044403",0.893,"biological process involved in symbiotic interaction"]
["GO:0009636","response to toxic substance","9/107","219/16199",{"v":1.45795788020208e-05,"d":"1.46E-05"},0.000696227069191004,0.000542200278145653,"APOE/TXN/PRDX1/GSTA1/EPHX1/NUPR1/GPX4/PRDX5/ALDH1A1",14,"GO:1990748",0.94,"cellular detoxification"]
["GO:0097193","intrinsic apoptotic signaling pathway","10/107","276/16199",{"v":1.43879951685548e-05,"d":"1.44E-05"},0.000696227069191004,0.000542200278145653,"HSPA1A/HSPB1/PPIA/UBB/RACK1/TPT1/HINT1/NUPR1/MIF/NDUFA13",9,"GO:2001242",0.942,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0016032","viral process","12/107","403/16199",{"v":1.40523018633038e-05,"d":"1.41E-05"},0.000696227069191004,0.000542200278145653,"HSPA1A/HSP90AB1/APOE/EEF1A1/PPIA/IFI27/HSPA1B/IFITM3/PPIB/CFL1/HSPA8/RAN",16,"GO:0016032",0.996,"viral process"]
["GO:0051099","positive regulation of binding","8/107","169/16199",{"v":1.61248267145062e-05,"d":"1.61E-05"},0.000755432919473941,0.000588307977647426,"HSP90AB1/APOE/S100A10/TXN/B2M/VTN/CALM2/RAN",13,"GO:0051098",0.934,"regulation of binding"]
["GO:1902532","negative regulation of intracellular signal transduction","13/107","481/16199",{"v":1.68977712740281e-05,"d":"1.69E-05"},0.000776984556915031,0.000605091731586541,"HSPA1A/HSPB1/APOE/PPIA/AMBP/PEBP1/TMSB4X/RACK1/NDUFC2/TPT1/PRAP1/MIF/NDUFA13",9,"GO:2001242",0.65,"regulation of intrinsic apoptotic signaling pathway"]
["GO:2001233","regulation of apoptotic signaling pathway","11/107","345/16199",{"v":1.74455879274489e-05,"d":"1.74E-05"},0.000787588996797373,0.000613350143975571,"HSPA1A/HSPB1/PPIA/UBB/HSPA1B/RACK1/TPT1/SLC25A5/NUPR1/MIF/NDUFA13",9,"GO:2001242",0.927,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0098754","detoxification","7/107","125/16199",{"v":1.89404112041159e-05,"d":"1.89E-05"},0.000839804303925353,0.00065401382296919,"APOE/TXN/PRDX1/GSTA1/GPX4/PRDX5/ALDH1A1",14,"GO:1990748",0.975,"cellular detoxification"]
["GO:0098869","cellular oxidant detoxification","6/107","87/16199",{"v":2.36043167804536e-05,"d":"2.36E-05"},0.00102823716782222,0.000800759555414465,"APOE/TXN/PRDX1/GSTA1/GPX4/PRDX5",14,"GO:1990748",0.988,"cellular detoxification"]
["GO:0070201","regulation of establishment of protein localization","13/107","500/16199",{"v":2.53597864191192e-05,"d":"2.54E-05"},0.00108566120135643,0.000845479630706387,"HSP90AB1/APOE/HSP90AA1/PPIA/RBP4/TXN/MPC2/IFI27/GLUL/RACK1/HSPA8/CCT3/RAN",17,"GO:0070201",0.996,"regulation of establishment of protein localization"]
["GO:0061136","regulation of proteasomal protein catabolic process","8/107","182/16199",{"v":2.75165425914457e-05,"d":"2.75E-05"},0.00115802669922982,0.000901835659955142,"HSPA1A/HSP90AB1/APOE/UBB/HSPA1B/RACK1/SUMO2/NUPR1",11,"GO:0009150",0.33,"purine ribonucleotide metabolic process"]
["GO:0030168","platelet activation","7/107","133/16199",{"v":2.82997970718981e-05,"d":"2.83E-05"},0.00117113993549205,0.000912047845983804,"HSPB1/APOE/PPIA/ACTB/ACTG1/MYL12A/CLIC1",18,"GO:0030168",0.999,"platelet activation"]
["GO:0019058","viral life cycle","10/107","305/16199",{"v":3.38781082601825e-05,"d":"3.39E-05"},0.00137900561983661,0.00107392726270846,"HSPA1A/HSP90AB1/APOE/EEF1A1/PPIA/IFI27/HSPA1B/IFITM3/PPIB/HSPA8",16,"GO:0016032",0.969,"viral process"]
["GO:2001243","negative regulation of intrinsic apoptotic signaling pathway","6/107","93/16199",{"v":3.45077971832939e-05,"d":"3.45E-05"},0.00138198161945353,0.00107624487989322,"HSPA1A/HSPB1/PPIA/TPT1/MIF/NDUFA13",9,"GO:2001242",0.96,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0034109","homotypic cell-cell adhesion","6/107","94/16199",{"v":3.66646358902575e-05,"d":"3.67E-05"},0.00144505223675412,0.00112536234136012,"HSPB1/PPIA/ACTB/ACTG1/MYL12A/CLIC1",15,"GO:0070527",0.981,"platelet aggregation"]
["GO:0002474","antigen processing and presentation of peptide antigen via MHC class I","4/107","29/16199",{"v":3.76294835275083e-05,"d":"3.76E-05"},0.0014599063687313,0.00113693028355317,"HLA-A/B2M/HLA-C/CALR",19,"GO:0002474",1,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0043393","regulation of protein binding","8/107","192/16199",{"v":4.03110192871909e-05,"d":"4.03E-05"},0.00153988093677069,0.00119921202316712,"HSP90AB1/APOE/ACTB/RACK1/B2M/VTN/RAN/CFHR1",13,"GO:0051098",0.943,"regulation of binding"]
["GO:0034368","protein-lipid complex remodeling","4/107","30/16199",{"v":4.31986332151953e-05,"d":"4.32E-05"},0.00160084591497521,0.00124668967751636,"APOA2/APOE/APOC2/APOC1",8,"GO:0051131",0.492,"chaperone-mediated protein complex assembly"]
["GO:0034369","plasma lipoprotein particle remodeling","4/107","30/16199",{"v":4.31986332151953e-05,"d":"4.32E-05"},0.00160084591497521,0.00124668967751636,"APOA2/APOE/APOC2/APOC1",8,"GO:0051131",0.492,"chaperone-mediated protein complex assembly"]
["GO:0034384","high-density lipoprotein particle clearance","3/107","11/16199",{"v":4.44858510403905e-05,"d":"4.45E-05"},0.00160084591497521,0.00124668967751636,"APOA2/APOE/APOC2",21,"GO:0034384",1,"high-density lipoprotein particle clearance"]
["GO:0090084","negative regulation of inclusion body assembly","3/107","11/16199",{"v":4.44858510403905e-05,"d":"4.45E-05"},0.00160084591497521,0.00124668967751636,"HSPA1A/HSPA1B/DNAJB1",20,"GO:0090084",1,"negative regulation of inclusion body assembly"]
["GO:0034605","cellular response to heat","5/107","60/16199",{"v":4.6830528380451e-05,"d":"4.68E-05"},0.00166114574240943,0.00129364933285547,"HSPA1A/HSP90AB1/HSP90AA1/HSPA1B/DNAJB1",22,"GO:0034605",1,"cellular response to heat"]
["GO:0062197","cellular response to chemical stress","10/107","320/16199",{"v":5.08002637028173e-05,"d":"5.08E-05"},0.00177657823625486,0.00138354461708044,"HSPA1A/HSPB1/AKR1C3/PPIA/TXN/PRDX1/HSPA1B/CHCHD2/RACK1/PRDX5",6,"GO:0006986",0.413,"response to unfolded protein"]
["GO:0034367","protein-containing complex remodeling","4/107","32/16199",{"v":5.61110883230585e-05,"d":"5.61E-05"},0.00193505322647437,0.00150696007674647,"APOA2/APOE/APOC2/APOC1",8,"GO:0051131",0.492,"chaperone-mediated protein complex assembly"]
["GO:0034370","triglyceride-rich lipoprotein particle remodeling","3/107","12/16199",{"v":5.90294372793826e-05,"d":"5.90E-05"},0.0019806769292528,0.00154249041653237,"APOA2/APOE/APOC2",8,"GO:0051131",0.464,"chaperone-mediated protein complex assembly"]
["GO:0034372","very-low-density lipoprotein particle remodeling","3/107","12/16199",{"v":5.90294372793826e-05,"d":"5.90E-05"},0.0019806769292528,0.00154249041653237,"APOA2/APOE/APOC2",8,"GO:0051131",0.456,"chaperone-mediated protein complex assembly"]
["GO:0051223","regulation of protein transport","12/107","475/16199",{"v":6.98540640761789e-05,"d":"6.99E-05"},0.00231263521468203,0.00180100934326934,"HSP90AB1/APOE/HSP90AA1/PPIA/RBP4/TXN/MPC2/IFI27/GLUL/RACK1/HSPA8/RAN",17,"GO:0070201",0.992,"regulation of establishment of protein localization"]
["GO:0033559","unsaturated fatty acid metabolic process","6/107","106/16199",{"v":7.20600524869341e-05,"d":"7.21E-05"},0.00235427776743497,0.00183343928557476,"AKR1C3/GSTA1/EPHX1/PTGES3/GPX4/MIF",23,"GO:0033559",0.999,"unsaturated fatty acid metabolic process"]
["GO:0009408","response to heat","6/107","107/16199",{"v":7.59353690064025e-05,"d":"7.59E-05"},0.00237032181092762,0.00184593389434429,"HSPA1A/HSPB1/HSP90AB1/HSP90AA1/HSPA1B/DNAJB1",22,"GO:0034605",0.962,"cellular response to heat"]
["GO:0032372","negative regulation of sterol transport","3/107","13/16199",{"v":7.63696113065684e-05,"d":"7.64E-05"},0.00237032181092762,0.00184593389434429,"APOA2/APOC2/APOC1",24,"GO:0032372",1,"negative regulation of sterol transport"]
["GO:0032375","negative regulation of cholesterol transport","3/107","13/16199",{"v":7.63696113065684e-05,"d":"7.64E-05"},0.00237032181092762,0.00184593389434429,"APOA2/APOC2/APOC1",24,"GO:0032372",1,"negative regulation of sterol transport"]
["GO:0120254","olefinic compound metabolic process","7/107","155/16199",{"v":7.51075194116461e-05,"d":"7.51E-05"},0.00237032181092762,0.00184593389434429,"AKR1C3/RBP4/GSTA1/EPHX1/PTGES3/GPX4/ALDH1A1",25,"GO:0120254",0.998,"olefinic compound metabolic process"]
["GO:1903050","regulation of proteolysis involved in protein catabolic process","8/107","211/16199",{"v":7.84025363276432e-05,"d":"7.84E-05"},0.0024033765148338,0.00187167588348123,"HSPA1A/HSP90AB1/APOE/UBB/HSPA1B/RACK1/SUMO2/NUPR1",11,"GO:0009150",0.335,"purine ribonucleotide metabolic process"]
["GO:0019730","antimicrobial humoral response","6/107","112/16199",{"v":9.78814393608721e-05,"d":"9.79E-05"},0.00290950133324889,0.00226583036190441,"GAPDH/FAU/RARRES2/HLA-A/HMGN2/LGALS4",19,"GO:0002474",0.367,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0051651","maintenance of location in cell","8/107","218/16199",{"v":9.84285589983515e-05,"d":"9.84E-05"},0.00290950133324889,0.00226583036190441,"FTL/FTH1/APOE/TXN/TMSB10/TMSB4X/CALR/CALM2",26,"GO:0051651",0.998,"maintenance of location in cell"]
["GO:2001234","negative regulation of apoptotic signaling pathway","8/107","218/16199",{"v":9.84285589983515e-05,"d":"9.84E-05"},0.00290950133324889,0.00226583036190441,"HSPA1A/HSPB1/PPIA/HSPA1B/TPT1/SLC25A5/MIF/NDUFA13",9,"GO:2001242",0.893,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0010498","proteasomal protein catabolic process","12/107","498/16199",0.000109330326223822,0.00315659534899708,0.00245825959942668,"HSPA1A/HSP90AB1/APOE/IFI27/UBB/HSPA1B/RACK1/SUMO2/CALR/PSMA7/NUPR1/SEC61B",11,"GO:0009150",0.371,"purine ribonucleotide metabolic process"]
["GO:0009896","positive regulation of catabolic process","12/107","498/16199",0.000109330326223822,0.00315659534899708,0.00245825959942668,"HSPA1A/APOA2/APOE/APOC2/HSP90AA1/HSPA1B/GPC3/RACK1/SUMO2/SLC25A5/NUPR1/NDUFA13",12,"GO:0042176",0.82,"regulation of protein catabolic process"]
["GO:0006690","icosanoid metabolic process","6/107","115/16199",0.000113295438486831,0.00323347785934254,0.00251813333938667,"AKR1C3/GSTA1/EPHX1/PTGES3/GPX4/MIF",23,"GO:0033559",0.648,"unsaturated fatty acid metabolic process"]
["GO:0045862","positive regulation of proteolysis","10/107","353/16199",0.000114703849628792,0.0032364733935033,0.00252046616947477,"HSPA1A/APOE/S100A10/HSPA1B/HSPE1/RACK1/SUMO2/NUPR1/NDUFA13/HSPD1",11,"GO:0009150",0.351,"purine ribonucleotide metabolic process"]
["GO:0007596","blood coagulation","8/107","224/16199",0.000118807923469845,0.00331460757275983,0.00258131467077593,"HSPB1/APOE/PPIA/ACTB/VTN/ACTG1/MYL12A/CLIC1",18,"GO:0030168",0.938,"platelet activation"]
["GO:1902570","protein localization to nucleolus","3/107","15/16199",0.000120333032426332,0.00331985466127314,0.0025854009423061,"GLUL/NPM1/RAN",17,"GO:0070201",0.494,"regulation of establishment of protein localization"]
["GO:0050817","coagulation","8/107","228/16199",0.000134242805043617,0.00366291082333299,0.00285256255483083,"HSPB1/APOE/PPIA/ACTB/VTN/ACTG1/MYL12A/CLIC1",18,"GO:0030168",0.936,"platelet activation"]
["GO:0034381","plasma lipoprotein particle clearance","4/107","40/16199",0.00013692981791197,0.00369561671603719,0.00287803290050674,"APOA2/APOE/APOC2/APOC1",21,"GO:0034384",0.902,"high-density lipoprotein particle clearance"]
["GO:0007599","hemostasis","8/107","230/16199",0.000142560110168228,0.00380620165105065,0.00296415305465801,"HSPB1/APOE/PPIA/ACTB/VTN/ACTG1/MYL12A/CLIC1",3,"GO:0050821",0.443,"protein stabilization"]
["GO:0019885","antigen processing and presentation of endogenous peptide antigen via MHC class I","3/107","16/16199",0.000147391292072178,0.00381221435640851,0.00296883556509419,"HLA-A/B2M/HLA-C",19,"GO:0002474",0.959,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0034375","high-density lipoprotein particle remodeling","3/107","16/16199",0.000147391292072178,0.00381221435640851,0.00296883556509419,"APOA2/APOE/APOC1",8,"GO:0051131",0.458,"chaperone-mediated protein complex assembly"]
["GO:0061684","chaperone-mediated autophagy","3/107","16/16199",0.000147391292072178,0.00381221435640851,0.00296883556509419,"HSP90AA1/EEF1A1/HSPA8",12,"GO:0042176",0.61,"regulation of protein catabolic process"]
["GO:0021762","substantia nigra development","4/107","41/16199",0.000150965658756811,0.00382497684380777,0.00297877459867091,"ACTB/DYNLL1/COX6B1/CALM2",27,"GO:0021762",1,"substantia nigra development"]
["GO:0019079","viral genome replication","6/107","121/16199",0.000149889652570421,0.00382497684380777,0.00297877459867091,"EEF1A1/PPIA/IFI27/IFITM3/PPIB/HSPA8",16,"GO:0016032",0.881,"viral process"]
["GO:0001906","cell killing","7/107","175/16199",0.000160238014176567,0.00401889888081227,0.00312979513070019,"HSP90AB1/GAPDH/PRDX1/HLA-A/B2M/HMGN2/TUBB",28,"GO:0001906",0.998,"cell killing"]
["GO:0009266","response to temperature stimulus","7/107","177/16199",0.000171886379046958,0.00426793879173596,0.00332373977167643,"HSPA1A/HSPB1/HSP90AB1/HSP90AA1/HSPA1B/DNAJB1/HSPD1",22,"GO:0034605",0.921,"cellular response to heat"]
["GO:0090083","regulation of inclusion body assembly","3/107","17/16199",0.000178116286155602,0.00429381299538213,0.00334388980754052,"HSPA1A/HSPA1B/DNAJB1",20,"GO:0090084",0.972,"negative regulation of inclusion body assembly"]
["GO:0043691","reverse cholesterol transport","3/107","17/16199",0.000178116286155602,0.00429381299538213,0.00334388980754052,"APOA2/APOE/APOC2",24,"GO:0032372",0.74,"negative regulation of sterol transport"]
["GO:0001895","retina homeostasis","5/107","79/16199",0.000174979476735231,0.00429381299538213,0.00334388980754052,"HSPB1/ACTB/PRDX1/B2M/ACTG1",3,"GO:0050821",0.396,"protein stabilization"]
["GO:1904951","positive regulation of establishment of protein localization","9/107","306/16199",0.000193185050795156,0.00461229308773434,0.00359191233107997,"HSP90AB1/HSP90AA1/PPIA/RBP4/MPC2/GLUL/RACK1/CCT3/RAN",17,"GO:0070201",0.946,"regulation of establishment of protein localization"]
["GO:0071827","plasma lipoprotein particle organization","4/107","44/16199",0.000199313492502747,0.0046688245460785,0.00363593729620205,"APOA2/APOE/APOC2/APOC1",8,"GO:0051131",0.504,"chaperone-mediated protein complex assembly"]
["GO:1903202","negative regulation of oxidative stress-induced cell death","4/107","44/16199",0.000199313492502747,0.0046688245460785,0.00363593729620205,"HSPB1/PPIA/TXN/RACK1",6,"GO:0006986",0.357,"response to unfolded protein"]
["GO:0002483","antigen processing and presentation of endogenous peptide antigen","3/107","18/16199",0.000212714150996561,0.00493616109275197,0.00384413079567813,"HLA-A/B2M/HLA-C",19,"GO:0002474",0.852,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0006692","prostanoid metabolic process","4/107","45/16199",0.000217653117545436,0.00495809808133318,0.00386121464926089,"AKR1C3/GSTA1/PTGES3/MIF",23,"GO:0033559",0.922,"unsaturated fatty acid metabolic process"]
["GO:0006693","prostaglandin metabolic process","4/107","45/16199",0.000217653117545436,0.00495809808133318,0.00386121464926089,"AKR1C3/GSTA1/PTGES3/MIF",23,"GO:0033559",0.922,"unsaturated fatty acid metabolic process"]
["GO:0032092","positive regulation of protein binding","5/107","83/16199",0.000220762133753367,0.00498320343736009,0.00388076593019077,"HSP90AB1/APOE/B2M/VTN/RAN",13,"GO:0051098",0.88,"regulation of binding"]
["GO:0032368","regulation of lipid transport","6/107","131/16199",0.000231113784891491,0.00516986962059073,0.0040261358259428,"APOA2/APOE/APOC2/APOC1/PRAP1/MIF",24,"GO:0032372",0.886,"negative regulation of sterol transport"]
["GO:0006414","translational elongation","4/107","46/16199",0.000237177427417396,0.00525813885961959,0.00409487720080598,"EEF1A1/RACK1/EEF1G/EEF1B2",29,"GO:0006414",0.999,"translational elongation"]
["GO:1900180","regulation of protein localization to nucleus","6/107","133/16199",0.000250876679505675,0.00551262650630612,0.00429306437123359,"HSP90AB1/HSP90AA1/GLUL/NPM1/CCT3/RAN",17,"GO:0070201",0.788,"regulation of establishment of protein localization"]
["GO:0071825","protein-lipid complex subunit organization","4/107","47/16199",0.000257930715349319,0.00561791198431894,0.00437505747088364,"APOA2/APOE/APOC2/APOC1",8,"GO:0051131",0.505,"chaperone-mediated protein complex assembly"]
["GO:1900182","positive regulation of protein localization to nucleus","5/107","86/16199",0.000260687319783017,0.00562857926105419,0.00438336481868561,"HSP90AB1/HSP90AA1/NPM1/CCT3/RAN",17,"GO:0070201",0.761,"regulation of establishment of protein localization"]
["GO:0031396","regulation of protein ubiquitination","7/107","191/16199",0.000274045748034356,0.0058659964859423,0.004568258068413,"HSPA1A/HSP90AB1/HSP90AA1/PPIA/UBB/HSPA1B/NPM1",11,"GO:0009150",0.334,"purine ribonucleotide metabolic process"]
["GO:0015748","organophosphate ester transport","6/107","142/16199",0.000356864516068385,0.00757345806322905,0.0058979767522953,"APOA2/APOE/APOC2/APOC1/SLC25A5/PRAP1",10,"GO:0033700",0.837,"phospholipid efflux"]
["GO:0030100","regulation of endocytosis","7/107","202/16199",0.000384615059545542,0.00809321349874221,0.00630274633706656,"APOE/APOC2/APOC1/CD63/GPC3/B2M/VTN",30,"GO:0030100",0.998,"regulation of endocytosis"]
["GO:0051258","protein polymerization","8/107","267/16199",0.000391421915976593,0.00816723207873849,0.0063603897359487,"HSPA1A/HSP90AA1/TMSB10/HSPA1B/TMSB4X/VTN/GPX4/ARPC3",8,"GO:0051131",0.572,"chaperone-mediated protein complex assembly"]
["GO:0045807","positive regulation of endocytosis","5/107","95/16199",0.000413819915236823,0.0085626237461086,0.0066683086341232,"APOE/CD63/GPC3/B2M/VTN",30,"GO:0030100",0.937,"regulation of endocytosis"]
["GO:0034620","cellular response to unfolded protein","5/107","96/16199",0.000434287885384252,0.00891187454057105,0.00694029443628421,"HSPA1A/HSPA1B/RACK1/HSPA8/HSPD1",6,"GO:0006986",0.978,"response to unfolded protein"]
["GO:0070841","inclusion body assembly","3/107","23/16199",0.000450703708949955,0.00917292876494047,0.00714359545591947,"HSPA1A/HSPA1B/DNAJB1",20,"GO:0090084",0.955,"negative regulation of inclusion body assembly"]
["GO:0033344","cholesterol efflux","4/107","55/16199",0.000473624598547329,0.00948395063058885,0.00738580974135351,"APOA2/APOE/APOC2/APOC1",24,"GO:0032372",0.815,"negative regulation of sterol transport"]
["GO:0019369","arachidonic acid metabolic process","4/107","55/16199",0.000473624598547329,0.00948395063058885,0.00738580974135351,"AKR1C3/EPHX1/PTGES3/GPX4",23,"GO:0033559",0.939,"unsaturated fatty acid metabolic process"]
["GO:0045833","negative regulation of lipid metabolic process","5/107","98/16199",0.000477505658566191,0.00948517240175882,0.00738676121925131,"APOA2/APOE/APOC2/AKR1C3/APOC1",31,"GO:0045833",0.999,"negative regulation of lipid metabolic process"]
["GO:0048144","fibroblast proliferation","5/107","99/16199",0.000500291531406363,0.00978129033450393,0.00761736877905917,"FTH1/PRDX1/NUPR1/PTGES3/MIF",32,"GO:0048144",0.999,"fibroblast proliferation"]
["GO:0015914","phospholipid transport","5/107","99/16199",0.000500291531406363,0.00978129033450393,0.00761736877905917,"APOA2/APOE/APOC2/APOC1/PRAP1",10,"GO:0033700",0.868,"phospholipid efflux"]
["GO:0052547","regulation of peptidase activity","10/107","426/16199",0.000515605818094324,0.00992441276223415,0.00772882813414339,"GAPDH/AMBP/GPC3/PEBP1/HSPE1/RACK1/VTN/NDUFA13/PRDX5/HSPD1",11,"GO:0009150",0.357,"purine ribonucleotide metabolic process"]
["GO:0006633","fatty acid biosynthetic process","6/107","152/16199",0.000512711990798659,0.00992441276223415,0.00772882813414339,"APOC2/AKR1C3/APOC1/PTGES3/GPX4/MIF",23,"GO:0033559",0.802,"unsaturated fatty acid metabolic process"]
["GO:1902903","regulation of supramolecular fiber organization","9/107","353/16199",0.000549806866772268,0.0105013111553503,0.008178098900896,"HSPA1A/APOE/S100A10/TMSB10/HSPA1B/TMSB4X/ACTG1/HSPA8/ARPC3",30,"GO:0030100",0.581,"regulation of endocytosis"]
["GO:0019883","antigen processing and presentation of endogenous antigen","3/107","25/16199",0.00057973707911724,0.0107531738226037,0.00837424181788713,"HLA-A/B2M/HLA-C",19,"GO:0002474",0.812,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0034377","plasma lipoprotein particle assembly","3/107","25/16199",0.00057973707911724,0.0107531738226037,0.00837424181788713,"APOA2/APOE/APOC1",8,"GO:0051131",0.492,"chaperone-mediated protein complex assembly"]
["GO:0006611","protein export from nucleus","4/107","58/16199",0.000580316267510633,0.0107531738226037,0.00837424181788713,"TXN/IFI27/CALR/RAN",17,"GO:0070201",0.628,"regulation of establishment of protein localization"]
["GO:0072331","signal transduction by p53 class mediator","6/107","155/16199",0.00056851051876562,0.0107531738226037,0.00837424181788713,"UBB/HINT1/NPM1/NUPR1/PRAP1/MIF",9,"GO:2001242",0.497,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0048002","antigen processing and presentation of peptide antigen","4/107","59/16199",0.00061938267040421,0.011308288019218,0.00880654772084005,"HLA-A/B2M/HLA-C/CALR",19,"GO:0002474",0.929,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0050994","regulation of lipid catabolic process","4/107","59/16199",0.00061938267040421,0.011308288019218,0.00880654772084005,"APOA2/APOC2/RARRES2/APOC1",31,"GO:0045833",0.784,"negative regulation of lipid metabolic process"]
["GO:1903829","positive regulation of protein localization","10/107","437/16199",0.000628222086420472,0.0113859521210367,0.00886703014025668,"HSP90AB1/HSP90AA1/PPIA/RBP4/MPC2/GLUL/RACK1/NPM1/CCT3/RAN",17,"GO:0070201",0.884,"regulation of establishment of protein localization"]
["GO:1905952","regulation of lipid localization","6/107","159/16199",0.000650127245603845,0.0116941325797172,0.00910703162513111,"APOA2/APOE/APOC2/APOC1/PRAP1/MIF",24,"GO:0032372",0.866,"negative regulation of sterol transport"]
["GO:0048259","regulation of receptor-mediated endocytosis","5/107","105/16199",0.000654645359879457,0.0116941325797172,0.00910703162513111,"APOC2/APOC1/CD63/B2M/VTN",30,"GO:0030100",0.949,"regulation of endocytosis"]
["GO:0051222","positive regulation of protein transport","8/107","290/16199",0.000675044055027569,0.011972388490239,0.00932372879011763,"HSP90AB1/HSP90AA1/PPIA/RBP4/MPC2/GLUL/RACK1/RAN",17,"GO:0070201",0.942,"regulation of establishment of protein localization"]
["GO:0001676","long-chain fatty acid metabolic process","5/107","107/16199",0.000713268120978845,0.0125606010240459,0.0097818106624721,"AKR1C3/GSTA1/EPHX1/PTGES3/GPX4",23,"GO:0033559",0.784,"unsaturated fatty acid metabolic process"]
["GO:0048857","neural nucleus development","4/107","62/16199",0.000747753173371724,0.013075148799169,0.0101825246811257,"ACTB/DYNLL1/COX6B1/CALM2",27,"GO:0021762",0.972,"substantia nigra development"]
["GO:0065005","protein-lipid complex assembly","3/107","28/16199",0.000813949746026633,0.0133843524462525,0.0104233229937325,"APOA2/APOE/APOC1",8,"GO:0051131",0.495,"chaperone-mediated protein complex assembly"]
["GO:0032369","negative regulation of lipid transport","3/107","28/16199",0.000813949746026633,0.0133843524462525,0.0104233229937325,"APOA2/APOC2/APOC1",24,"GO:0032372",0.974,"negative regulation of sterol transport"]
["GO:0032371","regulation of sterol transport","4/107","63/16199",0.000794425847160273,0.0133843524462525,0.0104233229937325,"APOA2/APOE/APOC2/APOC1",24,"GO:0032372",0.934,"negative regulation of sterol transport"]
["GO:0032374","regulation of cholesterol transport","4/107","63/16199",0.000794425847160273,0.0133843524462525,0.0104233229937325,"APOA2/APOE/APOC2/APOC1",24,"GO:0032372",0.934,"negative regulation of sterol transport"]
["GO:0051881","regulation of mitochondrial membrane potential","4/107","63/16199",0.000794425847160273,0.0133843524462525,0.0104233229937325,"UBB/RACK1/NDUFC2/CLIC1",3,"GO:0050821",0.392,"protein stabilization"]
["GO:0034504","protein localization to nucleus","8/107","297/16199",0.000788412848497546,0.0133843524462525,0.0104233229937325,"HSP90AB1/HSP90AA1/TXN/GLUL/NPM1/CALR/CCT3/RAN",17,"GO:0070201",0.619,"regulation of establishment of protein localization"]
["GO:0046822","regulation of nucleocytoplasmic transport","5/107","109/16199",0.000775732906412347,0.0133843524462525,0.0104233229937325,"HSP90AB1/HSP90AA1/TXN/IFI27/RAN",17,"GO:0070201",0.753,"regulation of establishment of protein localization"]
["GO:0001516","prostaglandin biosynthetic process","3/107","28/16199",0.000813949746026633,0.0133843524462525,0.0104233229937325,"AKR1C3/PTGES3/MIF",23,"GO:0033559",0.895,"unsaturated fatty acid metabolic process"]
["GO:0046457","prostanoid biosynthetic process","3/107","28/16199",0.000813949746026633,0.0133843524462525,0.0104233229937325,"AKR1C3/PTGES3/MIF",23,"GO:0033559",0.895,"unsaturated fatty acid metabolic process"]
["GO:0007004","telomere maintenance via telomerase","4/107","64/16199",0.000843119335496565,0.0137727980923551,0.0107258325436786,"HSP90AB1/HSP90AA1/PTGES3/CCT3",29,"GO:0006414",0.381,"translational elongation"]
["GO:1903320","regulation of protein modification by small protein conjugation or removal","7/107","231/16199",0.000853105069506152,0.0138448358665606,0.0107819333517909,"HSPA1A/HSP90AB1/HSP90AA1/PPIA/UBB/HSPA1B/NPM1",11,"GO:0009150",0.34,"purine ribonucleotide metabolic process"]
["GO:0006278","RNA-templated DNA biosynthetic process","4/107","65/16199",0.000893881456657138,0.0144123873823355,0.0112239250572738,"HSP90AB1/HSP90AA1/PTGES3/CCT3",29,"GO:0006414",0.383,"translational elongation"]
["GO:0001819","positive regulation of cytokine production","10/107","458/16199",0.000899966960075878,0.0144168900765704,0.0112274316173812,"HSPA1A/APOA2/HSPB1/GAPDH/HSP90AA1/HSPA1B/HLA-A/B2M/MIF/HSPD1",33,"GO:0001819",0.992,"positive regulation of cytokine production"]
["GO:1901800","positive regulation of proteasomal protein catabolic process","5/107","113/16199",0.000912818326774166,0.0144970479780731,0.011289856131471,"HSPA1A/HSPA1B/RACK1/SUMO2/NUPR1",11,"GO:0009150",0.315,"purine ribonucleotide metabolic process"]
["GO:0046394","carboxylic acid biosynthetic process","8/107","304/16199",0.000916647818186661,0.0144970479780731,0.011289856131471,"APOC2/AKR1C3/APOC1/GLUL/PTGES3/GPX4/MIF/ALDH1A1",23,"GO:0033559",0.691,"unsaturated fatty acid metabolic process"]
["GO:0016053","organic acid biosynthetic process","8/107","306/16199",0.000956208817830677,0.0150270031308454,0.011702568943071,"APOC2/AKR1C3/APOC1/GLUL/PTGES3/GPX4/MIF/ALDH1A1",23,"GO:0033559",0.686,"unsaturated fatty acid metabolic process"]
["GO:0035967","cellular response to topologically incorrect protein","5/107","115/16199",0.000987758692316098,0.0154251876290621,0.0120126628122123,"HSPA1A/HSPA1B/RACK1/HSPA8/HSPD1",6,"GO:0006986",0.969,"response to unfolded protein"]
["GO:0043254","regulation of protein-containing complex assembly","9/107","385/16199",0.00101742971773431,0.0157892374320893,0.0122961736281442,"HSPA1A/APOE/HSP90AA1/TMSB10/HSPA1B/TMSB4X/RACK1/HSPA8/ARPC3",8,"GO:0051131",0.583,"chaperone-mediated protein complex assembly"]
["GO:1903201","regulation of oxidative stress-induced cell death","4/107","68/16199",0.00105905820295224,0.0163331771300026,0.0127197771743921,"HSPB1/PPIA/TXN/RACK1",6,"GO:0006986",0.367,"response to unfolded protein"]
["GO:0061844","antimicrobial humoral immune response mediated by antimicrobial peptide","4/107","69/16199",0.00111857347286676,0.0171445551427665,0.0133516534740496,"GAPDH/FAU/HMGN2/LGALS4",19,"GO:0002474",0.353,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0097006","regulation of plasma lipoprotein particle levels","4/107","70/16199",0.00118039666598844,0.0179811344886461,0.0140031557986488,"APOA2/APOE/APOC2/APOC1",21,"GO:0034384",0.846,"high-density lipoprotein particle clearance"]
["GO:0052548","regulation of endopeptidase activity","9/107","397/16199",0.00126001820648112,0.0190769829676379,0.0148565689685867,"GAPDH/AMBP/PEBP1/HSPE1/RACK1/VTN/NDUFA13/PRDX5/HSPD1",11,"GO:0009150",0.354,"purine ribonucleotide metabolic process"]
["GO:0090150","establishment of protein localization to membrane","7/107","248/16199",0.00128837485789083,0.019388089528139,0.0150988492117732,"NACA/HSP90AA1/SRP14/RACK1/KRT18/NDUFA13/SEC61B",17,"GO:0070201",0.721,"regulation of establishment of protein localization"]
["GO:0045936","negative regulation of phosphate metabolic process","9/107","401/16199",0.00135056378776406,0.0202015053314347,0.0157323124801685,"HSPB1/APOE/PPIA/APOC1/DYNLL1/RACK1/NPM1/CALM2/NUPR1",7,"GO:0009205",0.523,"purine ribonucleoside triphosphate metabolic process"]
["GO:0010563","negative regulation of phosphorus metabolic process","9/107","402/16199",0.00137400246314254,0.0203989016338777,0.0158860386635154,"HSPB1/APOE/PPIA/APOC1/DYNLL1/RACK1/NPM1/CALM2/NUPR1",7,"GO:0009205",0.521,"purine ribonucleoside triphosphate metabolic process"]
["GO:0072332","intrinsic apoptotic signaling pathway by p53 class mediator","4/107","73/16199",0.00138019149194178,0.0203989016338777,0.0158860386635154,"UBB/HINT1/NUPR1/MIF",9,"GO:2001242",0.842,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0051235","maintenance of location","8/107","327/16199",0.0014603170335067,0.0211395574873254,0.0164628387155677,"FTL/FTH1/APOE/TXN/TMSB10/TMSB4X/CALR/CALM2",26,"GO:0051651",0.963,"maintenance of location in cell"]
["GO:0000302","response to reactive oxygen species","6/107","186/16199",0.00146435919767216,0.0211395574873254,0.0164628387155677,"APOE/AKR1C3/TXN/PRDX1/RACK1/PRDX5",6,"GO:0006986",0.393,"response to unfolded protein"]
["GO:0051973","positive regulation of telomerase activity","3/107","34/16199",0.00144464888114984,0.0211395574873254,0.0164628387155677,"HSP90AB1/HSP90AA1/PTGES3",29,"GO:0006414",0.356,"translational elongation"]
["GO:2000573","positive regulation of DNA biosynthetic process","4/107","74/16199",0.00145172377376212,0.0211395574873254,0.0164628387155677,"HSP90AB1/HSP90AA1/PTGES3/CCT3",29,"GO:0006414",0.38,"translational elongation"]
["GO:0034101","erythrocyte homeostasis","5/107","126/16199",0.00148447287233465,0.0213060470636239,0.0165924956889489,"HSPA1A/PRDX1/HSPA1B/B2M/SLC25A5",3,"GO:0050821",0.417,"protein stabilization"]
["GO:0032271","regulation of protein polymerization","6/107","189/16199",0.00158859820015057,0.0226694789136429,0.0176542945775959,"HSPA1A/HSP90AA1/TMSB10/HSPA1B/TMSB4X/ARPC3",8,"GO:0051131",0.557,"chaperone-mediated protein complex assembly"]
["GO:0010833","telomere maintenance via telomere lengthening","4/107","76/16199",0.00160247454295118,0.0227368245151302,0.0177067412655719,"HSP90AB1/HSP90AA1/PTGES3/CCT3",29,"GO:0006414",0.386,"translational elongation"]
["GO:0033135","regulation of peptidyl-serine phosphorylation","5/107","130/16199",0.00170413507453287,0.0239060304523452,0.0186172829730412,"HSP90AB1/HSP90AA1/TXN/RACK1/MIF",7,"GO:0009205",0.467,"purine ribonucleoside triphosphate metabolic process"]
["GO:1903052","positive regulation of proteolysis involved in protein catabolic process","5/107","130/16199",0.00170413507453287,0.0239060304523452,0.0186172829730412,"HSPA1A/HSPA1B/RACK1/SUMO2/NUPR1",11,"GO:0009150",0.32,"purine ribonucleotide metabolic process"]
["GO:0009206","purine ribonucleoside triphosphate biosynthetic process","4/107","79/16199",0.00184852558591431,0.0256418381554482,0.019969076749924,"TMSB4X/NDUFC2/NME2/NDUFA13",7,"GO:0009205",0.939,"purine ribonucleoside triphosphate metabolic process"]
["GO:1900407","regulation of cellular response to oxidative stress","4/107","79/16199",0.00184852558591431,0.0256418381554482,0.019969076749924,"HSPB1/PPIA/TXN/RACK1",6,"GO:0006986",0.372,"response to unfolded protein"]
["GO:0042989","sequestering of actin monomers","2/107","10/16199",0.00187901759678173,0.0257016605924364,0.0200156646282323,"TMSB10/TMSB4X",8,"GO:0051131",0.466,"chaperone-mediated protein complex assembly"]
["GO:0032434","regulation of proteasomal ubiquitin-dependent protein catabolic process","5/107","133/16199",0.00188389135232518,0.0257016605924364,0.0200156646282323,"HSPA1A/HSP90AB1/HSPA1B/RACK1/SUMO2",11,"GO:0009150",0.321,"purine ribonucleotide metabolic process"]
["GO:0051342","regulation of cyclic-nucleotide phosphodiesterase activity","2/107","10/16199",0.00187901759678173,0.0257016605924364,0.0200156646282323,"RACK1/CALM2",13,"GO:0051098",0.427,"regulation of binding"]
["GO:0009145","purine nucleoside triphosphate biosynthetic process","4/107","80/16199",0.00193604415725661,0.0262688395763288,0.020457366217316,"TMSB4X/NDUFC2/NME2/NDUFA13",7,"GO:0009205",0.936,"purine ribonucleoside triphosphate metabolic process"]
["GO:0051346","negative regulation of hydrolase activity","8/107","343/16199",0.00197078491206373,0.0265564329031874,0.0206813350756323,"APOA2/GAPDH/AMBP/APOC1/GPC3/PEBP1/VTN/PRDX5",13,"GO:0051098",0.561,"regulation of binding"]
["GO:0042060","wound healing","9/107","424/16199",0.00197863072375742,0.0265564329031874,0.0206813350756323,"HSPB1/APOE/S100A10/PPIA/ACTB/VTN/ACTG1/MYL12A/CLIC1",6,"GO:0006986",0.425,"response to unfolded protein"]
["GO:0045454","cell redox homeostasis","3/107","38/16199",0.00199800842719995,0.0266723383050402,0.0207715986461025,"TXN/PRDX1/PRDX5",3,"GO:0050821",0.378,"protein stabilization"]
["GO:0032677","regulation of interleukin-8 production","4/107","81/16199",0.00202639151299431,0.026906578217994,0.0209540175027895,"HSPA1A/APOA2/HSPA1B/TMSB4X",33,"GO:0001819",0.705,"positive regulation of cytokine production"]
["GO:0071383","cellular response to steroid hormone stimulus","6/107","200/16199",0.0021139460770073,0.0271288766933308,0.0211271367342767,"HSPA1A/AKR1C3/HSPA1B/CALR/PTGES3/HSPA8",34,"GO:0071383",0.998,"cellular response to steroid hormone stimulus"]
["GO:0032637","interleukin-8 production","4/107","82/16199",0.00211961420801698,0.0271288766933308,0.0211271367342767,"HSPA1A/APOA2/HSPA1B/TMSB4X",33,"GO:0001819",0.703,"positive regulation of cytokine production"]
["GO:0001894","tissue homeostasis","7/107","270/16199",0.00209071420785014,0.0271288766933308,0.0211271367342767,"HSPB1/ACTB/RBP4/PRDX1/B2M/ACTG1/ALDH1A1",3,"GO:0050821",0.435,"protein stabilization"]
["GO:0042326","negative regulation of phosphorylation","8/107","346/16199",0.00208051649064782,0.0271288766933308,0.0211271367342767,"HSPB1/APOE/PPIA/DYNLL1/RACK1/NPM1/CALM2/NUPR1",7,"GO:0009205",0.517,"purine ribonucleoside triphosphate metabolic process"]
["GO:0030705","cytoskeleton-dependent intracellular transport","6/107","200/16199",0.0021139460770073,0.0271288766933308,0.0211271367342767,"HSPB1/UBB/DYNLL1/TUBA1B/HSPA8/TUBB",17,"GO:0070201",0.509,"regulation of establishment of protein localization"]
["GO:0072594","establishment of protein localization to organelle","9/107","427/16199",0.00207542523246393,0.0271288766933308,0.0211271367342767,"HSP90AB1/HSP90AA1/SRP14/HSPA8/NDUFA13/CCT3/RAN/SEC61B/HSPD1",17,"GO:0070201",0.751,"regulation of establishment of protein localization"]
["GO:0034614","cellular response to reactive oxygen species","5/107","136/16199",0.00207716378699136,0.0271288766933308,0.0211271367342767,"AKR1C3/TXN/PRDX1/RACK1/PRDX5",6,"GO:0006986",0.382,"response to unfolded protein"]
["GO:0042921","glucocorticoid receptor signaling pathway","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"CALR/PTGES3",34,"GO:0071383",0.807,"cellular response to steroid hormone stimulus"]
["GO:1903265","positive regulation of tumor necrosis factor-mediated signaling pathway","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"HSPA1A/HSPA1B",34,"GO:0071383",0.423,"cellular response to steroid hormone stimulus"]
["GO:0010968","regulation of microtubule nucleation","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"HSPA1A/HSPA1B",8,"GO:0051131",0.46,"chaperone-mediated protein complex assembly"]
["GO:0010985","negative regulation of lipoprotein particle clearance","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"APOC2/APOC1",21,"GO:0034384",0.844,"high-density lipoprotein particle clearance"]
["GO:0006122","mitochondrial electron transport, ubiquinol to cytochrome c","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"UQCRB/UQCRH",1,"GO:0006119",0.837,"oxidative phosphorylation"]
["GO:0099188","postsynaptic cytoskeleton organization","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"ACTB/ACTG1",35,"GO:0099188",1,"postsynaptic cytoskeleton organization"]
["GO:0045793","positive regulation of cell size","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"HSP90AB1/HSP90AA1",3,"GO:0050821",0.346,"protein stabilization"]
["GO:1902947","regulation of tau-protein kinase activity","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"HSP90AB1/HSP90AA1",7,"GO:0009205",0.394,"purine ribonucleoside triphosphate metabolic process"]
["GO:2001171","positive regulation of ATP biosynthetic process","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"TMSB4X/NDUFC2",7,"GO:0009205",0.794,"purine ribonucleoside triphosphate metabolic process"]
["GO:0043161","proteasome-mediated ubiquitin-dependent protein catabolic process","9/107","431/16199",0.00221034036412098,0.0276968514279853,0.0215694580296369,"HSPA1A/HSP90AB1/IFI27/HSPA1B/RACK1/SUMO2/CALR/PSMA7/SEC61B",11,"GO:0009150",0.363,"purine ribonucleotide metabolic process"]
["GO:1904729","regulation of intestinal lipid absorption","2/107","11/16199",0.00228669131805759,0.0276968514279853,0.0215694580296369,"APOA2/PRAP1",36,"GO:1904729",1,"regulation of intestinal lipid absorption"]
["GO:0042307","positive regulation of protein import into nucleus","3/107","40/16199",0.00231774858917907,0.0279367463443283,0.0217562808294428,"HSP90AB1/HSP90AA1/RAN",17,"GO:0070201",0.8,"regulation of establishment of protein localization"]
["GO:0072330","monocarboxylic acid biosynthetic process","6/107","204/16199",0.00233434767126228,0.0280008950132571,0.0218062378444383,"APOC2/AKR1C3/APOC1/PTGES3/GPX4/MIF",23,"GO:0033559",0.753,"unsaturated fatty acid metabolic process"]
["GO:0009201","ribonucleoside triphosphate biosynthetic process","4/107","85/16199",0.00241699711171139,0.0288529030210547,0.0224697555375193,"TMSB4X/NDUFC2/NME2/NDUFA13",7,"GO:0009205",0.937,"purine ribonucleoside triphosphate metabolic process"]
["GO:0001523","retinoid metabolic process","4/107","86/16199",0.00252218295522009,0.0298218108467214,0.0232243112217509,"AKR1C3/RBP4/RARRES2/ALDH1A1",31,"GO:0045833",0.523,"negative regulation of lipid metabolic process"]
["GO:1902882","regulation of response to oxidative stress","4/107","86/16199",0.00252218295522009,0.0298218108467214,0.0232243112217509,"HSPB1/PPIA/TXN/RACK1",6,"GO:0006986",0.374,"response to unfolded protein"]
["GO:0030901","midbrain development","4/107","87/16199",0.00263047400846184,0.0308088064292959,0.0239929530960496,"ACTB/DYNLL1/COX6B1/CALM2",37,"GO:0030901",0.999,"midbrain development"]
["GO:0036473","cell death in response to oxidative stress","4/107","87/16199",0.00263047400846184,0.0308088064292959,0.0239929530960496,"HSPB1/PPIA/TXN/RACK1",6,"GO:0006986",0.373,"response to unfolded protein"]
["GO:0031958","corticosteroid receptor signaling pathway","2/107","12/16199",0.00273222369421323,0.0318502884165795,0.0248040273104507,"CALR/PTGES3",34,"GO:0071383",0.811,"cellular response to steroid hormone stimulus"]
["GO:1990542","mitochondrial transmembrane transport","4/107","89/16199",0.00285655281064122,0.0326858093494108,0.0254547053754446,"MPC2/SLC25A5/SLC25A3/HSPD1",26,"GO:0051651",0.312,"maintenance of location in cell"]
["GO:0016101","diterpenoid metabolic process","4/107","89/16199",0.00285655281064122,0.0326858093494108,0.0254547053754446,"AKR1C3/RBP4/RARRES2/ALDH1A1",31,"GO:0045833",0.524,"negative regulation of lipid metabolic process"]
["GO:0045646","regulation of erythrocyte differentiation","3/107","43/16199",0.00285389005394287,0.0326858093494108,0.0254547053754446,"HSPA1A/HSPA1B/B2M",3,"GO:0050821",0.382,"protein stabilization"]
["GO:0032436","positive regulation of proteasomal ubiquitin-dependent protein catabolic process","4/107","89/16199",0.00285655281064122,0.0326858093494108,0.0254547053754446,"HSPA1A/HSPA1B/RACK1/SUMO2",11,"GO:0009150",0.31,"purine ribonucleotide metabolic process"]
["GO:0006959","humoral immune response","7/107","286/16199",0.00288438396558838,0.0328528687456695,0.0255848061071263,"GAPDH/FAU/RARRES2/HLA-A/HMGN2/LGALS4/CFHR1",19,"GO:0002474",0.391,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:1901029","negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway","2/107","13/16199",0.00321510625474171,0.0360156391940623,0.0280478746844829,"HSPA1A/SLC25A5",39,"GO:1901029",1,"negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"]
["GO:0032091","negative regulation of protein binding","4/107","92/16199",0.00322008534074983,0.0360156391940623,0.0280478746844829,"ACTB/RACK1/B2M/CFHR1",13,"GO:0051098",0.887,"regulation of binding"]
["GO:1904478","regulation of intestinal absorption","2/107","13/16199",0.00321510625474171,0.0360156391940623,0.0280478746844829,"APOA2/PRAP1",36,"GO:1904729",0.993,"regulation of intestinal lipid absorption"]
["GO:0070424","regulation of nucleotide-binding oligomerization domain containing signaling pathway","2/107","13/16199",0.00321510625474171,0.0360156391940623,0.0280478746844829,"HSPA1A/HSPA1B",38,"GO:0070424",1,"regulation of nucleotide-binding oligomerization domain containing signaling pathway"]
["GO:1905953","negative regulation of lipid localization","3/107","45/16199",0.00325030409515734,0.0361906056873348,0.028184133220694,"APOA2/APOC2/APOC1",24,"GO:0032372",0.948,"negative regulation of sterol transport"]
["GO:0060326","cell chemotaxis","7/107","294/16199",0.00335914693086809,0.036906025793564,0.0287412804471574,"HSPB1/PPIA/RARRES2/TMSB4X/PPIB/CALR/MIF",40,"GO:0060326",0.996,"cell chemotaxis"]
["GO:1901222","regulation of NIK/NF-kappaB signaling","4/107","93/16199",0.00334795089053147,0.036906025793564,0.0287412804471574,"PRDX1/TMSB4X/NDUFC2/CALR",9,"GO:2001242",0.561,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0090398","cellular senescence","4/107","93/16199",0.00334795089053147,0.036906025793564,0.0287412804471574,"B2M/NPM1/CALR/MIF",6,"GO:0006986",0.374,"response to unfolded protein"]
["GO:0009615","response to virus","8/107","375/16199",0.00340882798131858,0.0372868717075508,0.0290378715589252,"HSPB1/HSP90AA1/IFI27/IFITM3/CFL1/TPT1/EEF1G/CALR",4,"GO:0044403",0.632,"biological process involved in symbiotic interaction"]
["GO:0035307","positive regulation of protein dephosphorylation","3/107","46/16199",0.0034605222347671,0.0375217323533917,0.0292207738233379,"HSP90AB1/PPIA/CALM2",11,"GO:0009150",0.461,"purine ribonucleotide metabolic process"]
["GO:0051972","regulation of telomerase activity","3/107","46/16199",0.0034605222347671,0.0375217323533917,0.0292207738233379,"HSP90AB1/HSP90AA1/PTGES3",29,"GO:0006414",0.365,"translational elongation"]
["GO:0006631","fatty acid metabolic process","8/107","378/16199",0.00357704741633774,0.0386165597163766,0.0300733917794619,"APOC2/AKR1C3/APOC1/GSTA1/EPHX1/PTGES3/GPX4/MIF",23,"GO:0033559",0.879,"unsaturated fatty acid metabolic process"]
["GO:0006641","triglyceride metabolic process","4/107","95/16199",0.00361397711187947,0.0388463427220638,0.0302523397335274,"APOA2/APOE/APOC2/APOC1",31,"GO:0045833",0.518,"negative regulation of lipid metabolic process"]
["GO:0034380","high-density lipoprotein particle assembly","2/107","14/16199",0.00373483548538424,0.0390094972377752,0.0303793994640579,"APOA2/APOE",8,"GO:0051131",0.476,"chaperone-mediated protein complex assembly"]
["GO:2001140","positive regulation of phospholipid transport","2/107","14/16199",0.00373483548538424,0.0390094972377752,0.0303793994640579,"APOE/PRAP1",24,"GO:0032372",0.756,"negative regulation of sterol transport"]
["GO:0009142","nucleoside triphosphate biosynthetic process","4/107","96/16199",0.00375222446955318,0.0390094972377752,0.0303793994640579,"TMSB4X/NDUFC2/NME2/NDUFA13",7,"GO:0009205",0.927,"purine ribonucleoside triphosphate metabolic process"]
["GO:0051896","regulation of protein kinase B signaling","5/107","156/16199",0.00375484085373672,0.0390094972377752,0.0303793994640579,"HSP90AB1/HSP90AA1/AKR1C3/TXN/RACK1",9,"GO:2001242",0.582,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0000054","ribosomal subunit export from nucleus","2/107","14/16199",0.00373483548538424,0.0390094972377752,0.0303793994640579,"NPM1/RAN",41,"GO:0033750",1,"ribosome localization"]
["GO:0033750","ribosome localization","2/107","14/16199",0.00373483548538424,0.0390094972377752,0.0303793994640579,"NPM1/RAN",41,"GO:0033750",1,"ribosome localization"]
["GO:0006636","unsaturated fatty acid biosynthetic process","3/107","47/16199",0.00367888074745468,0.0390094972377752,0.0303793994640579,"AKR1C3/PTGES3/MIF",23,"GO:0033559",0.92,"unsaturated fatty acid metabolic process"]
["GO:0062014","negative regulation of small molecule metabolic process","4/107","96/16199",0.00375222446955318,0.0390094972377752,0.0303793994640579,"APOE/AKR1C3/APOC1/NUPR1",23,"GO:0033559",0.493,"unsaturated fatty acid metabolic process"]
["GO:0051100","negative regulation of binding","5/107","157/16199",0.00385834693060497,0.0399178142862172,0.0310867689101812,"ACTB/TMSB4X/RACK1/B2M/CFHR1",13,"GO:0051098",0.928,"regulation of binding"]
["GO:0050878","regulation of body fluid levels","8/107","384/16199",0.00393279710293333,0.040519233222338,0.0315551355234266,"HSPB1/APOE/PPIA/ACTB/VTN/ACTG1/MYL12A/CLIC1",3,"GO:0050821",0.46,"protein stabilization"]
["GO:0002262","myeloid cell homeostasis","5/107","158/16199",0.00396388371918565,0.0406707573336279,0.0316731378518662,"HSPA1A/PRDX1/HSPA1B/B2M/SLC25A5",3,"GO:0050821",0.425,"protein stabilization"]
["GO:0006165","nucleoside diphosphate phosphorylation","4/107","98/16199",0.00403940214982463,0.0412750433663151,0.0321437372719422,"GAPDH/NME2/TPI1/NUPR1",7,"GO:0009205",0.739,"purine ribonucleoside triphosphate metabolic process"]
["GO:2000058","regulation of ubiquitin-dependent protein catabolic process","5/107","159/16199",0.00407147321508116,0.0414322458731415,0.0322661617605871,"HSPA1A/HSP90AB1/HSPA1B/RACK1/SUMO2",11,"GO:0009150",0.327,"purine ribonucleotide metabolic process"]
["GO:2001028","positive regulation of endothelial cell chemotaxis","2/107","15/16199",0.00429091278583931,0.0421314867451065,0.0328107090958563,"HSPB1/TMSB4X",40,"GO:0060326",0.767,"cell chemotaxis"]
["GO:2001138","regulation of phospholipid transport","2/107","15/16199",0.00429091278583931,0.0421314867451065,0.0328107090958563,"APOE/PRAP1",24,"GO:0032372",0.758,"negative regulation of sterol transport"]
["GO:0017014","protein nitrosylation","2/107","15/16199",0.00429091278583931,0.0421314867451065,0.0328107090958563,"GAPDH/TXN",42,"GO:0018119",1,"peptidyl-cysteine S-nitrosylation"]
["GO:0018119","peptidyl-cysteine S-nitrosylation","2/107","15/16199",0.00429091278583931,0.0421314867451065,0.0328107090958563,"GAPDH/TXN",42,"GO:0018119",1,"peptidyl-cysteine S-nitrosylation"]
["GO:0099173","postsynapse organization","5/107","160/16199",0.00418113738542451,0.0421314867451065,0.0328107090958563,"APOE/ACTB/CFL1/ACTG1/HSPA8",35,"GO:0099188",0.818,"postsynaptic cytoskeleton organization"]
["GO:0033138","positive regulation of peptidyl-serine phosphorylation","4/107","99/16199",0.00418841733375803,0.0421314867451065,0.0328107090958563,"HSP90AB1/HSP90AA1/TXN/MIF",7,"GO:0009205",0.457,"purine ribonucleoside triphosphate metabolic process"]
["GO:0006605","protein targeting","7/107","307/16199",0.00425537207764191,0.0421314867451065,0.0328107090958563,"NACA/HSP90AA1/SRP14/HSPA8/NDUFA13/SEC61B/HSPD1",17,"GO:0070201",0.733,"regulation of establishment of protein localization"]
["GO:0051168","nuclear export","5/107","161/16199",0.00429289816613449,0.0421314867451065,0.0328107090958563,"TXN/IFI27/NPM1/CALR/RAN",17,"GO:0070201",0.496,"regulation of establishment of protein localization"]
["GO:0070431","nucleotide-binding oligomerization domain containing 2 signaling pathway","2/107","15/16199",0.00429091278583931,0.0421314867451065,0.0328107090958563,"HSPA1A/HSPA1B",38,"GO:0070424",0.927,"regulation of nucleotide-binding oligomerization domain containing signaling pathway"]
["GO:0006721","terpenoid metabolic process","4/107","100/16199",0.00434110612376895,0.0422704568836012,0.0329189347754946,"AKR1C3/RBP4/RARRES2/ALDH1A1",31,"GO:0045833",0.529,"negative regulation of lipid metabolic process"]
["GO:0046939","nucleotide phosphorylation","4/107","100/16199",0.00434110612376895,0.0422704568836012,0.0329189347754946,"GAPDH/NME2/TPI1/NUPR1",7,"GO:0009205",0.467,"purine ribonucleoside triphosphate metabolic process"]
["GO:0010594","regulation of endothelial cell migration","5/107","162/16199",0.00440677745919263,0.0427422985592785,0.0332863905943127,"HSPB1/APOE/GLUL/TMSB4X/CALR",40,"GO:0060326",0.678,"cell chemotaxis"]
["GO:0033209","tumor necrosis factor-mediated signaling pathway","4/107","101/16199",0.0044975101448303,0.0434525980140608,0.0338395500145536,"HSPA1A/HSPA1B/TMSB4X/KRT18",34,"GO:0071383",0.495,"cellular response to steroid hormone stimulus"]
["GO:0062012","regulation of small molecule metabolic process","7/107","311/16199",0.00456461387111925,0.0439299854340663,0.0342113246888864,"APOE/APOC2/AKR1C3/APOC1/TMSB4X/NDUFC2/NUPR1",23,"GO:0033559",0.547,"unsaturated fatty acid metabolic process"]
["GO:0019882","antigen processing and presentation","4/107","102/16199",0.0046576706882902,0.0444807550731714,0.0346402471837615,"HLA-A/B2M/HLA-C/CALR",19,"GO:0002474",0.899,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0030301","cholesterol transport","4/107","102/16199",0.0046576706882902,0.0444807550731714,0.0346402471837615,"APOA2/APOE/APOC2/APOC1",24,"GO:0032372",0.861,"negative regulation of sterol transport"]
["GO:0045926","negative regulation of growth","6/107","235/16199",0.00467784984434334,0.0445023033084464,0.0346570282881981,"HSPA1A/RBP4/HSPA1B/GPC3/RACK1/NDUFA13",43,"GO:0045926",0.998,"negative regulation of growth"]
["GO:0002440","production of molecular mediator of immune response","7/107","313/16199",0.00472547111420479,0.0447837586892003,0.0348762171024274,"APOA2/RBP4/HLA-A/B2M/MIF/LGALS4/HSPD1",19,"GO:0002474",0.388,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0034374","low-density lipoprotein particle remodeling","2/107","16/16199",0.00488284442780605,0.0450254040166159,0.0350644030686663,"APOA2/APOE",8,"GO:0051131",0.453,"chaperone-mediated protein complex assembly"]
["GO:2001169","regulation of ATP biosynthetic process","2/107","16/16199",0.00488284442780605,0.0450254040166159,0.0350644030686663,"TMSB4X/NDUFC2",7,"GO:0009205",0.824,"purine ribonucleoside triphosphate metabolic process"]
["GO:0060192","negative regulation of lipase activity","2/107","16/16199",0.00488284442780605,0.0450254040166159,0.0350644030686663,"APOA2/APOC1",13,"GO:0051098",0.448,"regulation of binding"]
["GO:0048260","positive regulation of receptor-mediated endocytosis","3/107","52/16199",0.00489603668324055,0.0450254040166159,0.0350644030686663,"CD63/B2M/VTN",30,"GO:0030100",0.894,"regulation of endocytosis"]
["GO:2001244","positive regulation of intrinsic apoptotic signaling pathway","3/107","52/16199",0.00489603668324055,0.0450254040166159,0.0350644030686663,"UBB/RACK1/NUPR1",9,"GO:2001242",0.923,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0048385","regulation of retinoic acid receptor signaling pathway","2/107","16/16199",0.00488284442780605,0.0450254040166159,0.0350644030686663,"AKR1C3/CALR",38,"GO:0070424",0.661,"regulation of nucleotide-binding oligomerization domain containing signaling pathway"]
["GO:1901032","negative regulation of response to reactive oxygen species","2/107","16/16199",0.00488284442780605,0.0450254040166159,0.0350644030686663,"TXN/RACK1",6,"GO:0006986",0.337,"response to unfolded protein"]
["GO:1903206","negative regulation of hydrogen peroxide-induced cell death","2/107","16/16199",0.00488284442780605,0.0450254040166159,0.0350644030686663,"TXN/RACK1",6,"GO:0006986",0.334,"response to unfolded protein"]
["GO:0019731","antibacterial humoral response","3/107","53/16199",0.00516515195629696,0.046636626572674,0.0363191737558565,"FAU/HLA-A/LGALS4",19,"GO:0002474",0.345,"antigen processing and presentation of peptide antigen via MHC class I"]
["GO:0009395","phospholipid catabolic process","3/107","53/16199",0.00516515195629696,0.046636626572674,0.0363191737558565,"APOA2/APOC2/APOC1",31,"GO:0045833",0.494,"negative regulation of lipid metabolic process"]
["GO:2000060","positive regulation of ubiquitin-dependent protein catabolic process","4/107","105/16199",0.00516109923721065,0.046636626572674,0.0363191737558565,"HSPA1A/HSPA1B/RACK1/SUMO2",11,"GO:0009150",0.314,"purine ribonucleotide metabolic process"]
["GO:0051897","positive regulation of protein kinase B signaling","4/107","105/16199",0.00516109923721065,0.046636626572674,0.0363191737558565,"HSP90AB1/HSP90AA1/AKR1C3/TXN",9,"GO:2001242",0.561,"regulation of intrinsic apoptotic signaling pathway"]
["GO:0046164","alcohol catabolic process","3/107","53/16199",0.00516515195629696,0.046636626572674,0.0363191737558565,"APOE/AKR1C3/TPI1",12,"GO:0042176",0.521,"regulation of protein catabolic process"]
["GO:0045861","negative regulation of proteolysis","7/107","319/16199",0.00523382624161403,0.0470854730359697,0.0366687216088672,"HSP90AB1/GAPDH/AMBP/GPC3/PEBP1/VTN/PRDX5",11,"GO:0009150",0.348,"purine ribonucleotide metabolic process"]
["GO:0042572","retinol metabolic process","3/107","54/16199",0.00544301936004859,0.0480590517101128,0.0374269148065698,"AKR1C3/RBP4/ALDH1A1",31,"GO:0045833",0.489,"negative regulation of lipid metabolic process"]
["GO:0007006","mitochondrial membrane organization","4/107","107/16199",0.00551624234288448,0.0480590517101128,0.0374269148065698,"HSPA1A/HSP90AA1/SLC25A5/NDUFA13",39,"GO:1901029",0.836,"negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"]
["GO:0010466","negative regulation of peptidase activity","6/107","242/16199",0.00538685677117241,0.0480590517101128,0.0374269148065698,"GAPDH/AMBP/GPC3/PEBP1/VTN/PRDX5",13,"GO:0051098",0.544,"regulation of binding"]
["GO:0006614","SRP-dependent cotranslational protein targeting to membrane","2/107","17/16199",0.00551014151335944,0.0480590517101128,0.0374269148065698,"SRP14/SEC61B",17,"GO:0070201",0.59,"regulation of establishment of protein localization"]
["GO:0006913","nucleocytoplasmic transport","7/107","322/16199",0.00550294138629962,0.0480590517101128,0.0374269148065698,"HSP90AB1/HSP90AA1/TXN/IFI27/NPM1/CALR/RAN",17,"GO:0070201",0.528,"regulation of establishment of protein localization"]
["GO:0051169","nuclear transport","7/107","322/16199",0.00550294138629962,0.0480590517101128,0.0374269148065698,"HSP90AB1/HSP90AA1/TXN/IFI27/NPM1/CALR/RAN",17,"GO:0070201",0.528,"regulation of establishment of protein localization"]
["GO:1902176","negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway","2/107","17/16199",0.00551014151335944,0.0480590517101128,0.0374269148065698,"HSPB1/PPIA",6,"GO:0006986",0.332,"response to unfolded protein"]
["GO:0006090","pyruvate metabolic process","4/107","107/16199",0.00551624234288448,0.0480590517101128,0.0374269148065698,"GAPDH/MPC2/TPI1/NUPR1",23,"GO:0033559",0.705,"unsaturated fatty acid metabolic process"]
["GO:0046456","icosanoid biosynthetic process","3/107","54/16199",0.00544301936004859,0.0480590517101128,0.0374269148065698,"AKR1C3/PTGES3/MIF",23,"GO:0033559",0.598,"unsaturated fatty acid metabolic process"]
["GO:0060249","anatomical structure homeostasis","7/107","324/16199",0.00568804545700741,0.0493825764676552,0.0384576352761229,"HSPB1/ACTB/RBP4/PRDX1/B2M/ACTG1/ALDH1A1",3,"GO:0050821",0.442,"protein stabilization"]
["GO:0051055","negative regulation of lipid biosynthetic process","3/107","55/16199",0.00572971521167367,0.0493988988562004,0.0384703466514785,"APOE/AKR1C3/APOC1",31,"GO:0045833",0.958,"negative regulation of lipid metabolic process"]
["GO:0006826","iron ion transport","3/107","55/16199",0.00572971521167367,0.0493988988562004,0.0384703466514785,"FTL/FTH1/B2M",5,"GO:1902600",0.553,"proton transmembrane transport"]

{"sheet":"Supplementary Table 2","index":2,"n_rows":31,"n_cols":8,"rows_kept":31,"merged":[[0,0,0,7]],"flags":["formulas_cached_only"]}
["Supplementary Table 2. KEGG pathways that are enriched for HepScope gene set. "]
["KEGG ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID"]
["hsa05012","Parkinson disease","20/79","237/7675",{"v":1.46905430620654e-13,"d":"1.47E-13"},{"v":2.46801123442699e-11,"d":"2.47E-11"},{"v":1.88657500375998e-11,"d":"1.89E-11"},"TXN/UBB/UBA52/UBC/COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/TUBA1B/SLC25A5/CALM2/PSMA7/COX5B/NDUFA13/UQCRH/COX4I1/TUBB/COX8A"]
["hsa05020","Prion disease","18/79","245/7675",{"v":3.07992912639671e-11,"d":"3.08E-11"},{"v":2.58714046617324e-09,"d":"2.59E-09"},{"v":1.97763870221263e-09,"d":"1.98E-09"},"HSPA1A/HSPA1B/COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/TUBA1B/SLC25A5/PSMA7/HSPA8/COX5B/NDUFA13/UQCRH/COX4I1/TUBB/COX8A"]
["hsa05208","Chemical carcinogenesis - reactive oxygen species","15/79","195/7675",{"v":8.96181937760612e-10,"d":"8.96E-10"},{"v":5.01861885145943e-08,"d":"5.02E-08"},{"v":3.83628759322086e-08,"d":"3.84E-08"},"AKR1C3/COX6A1/GSTA1/EPHX1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/SLC25A5/COX5B/NDUFA13/UQCRH/COX4I1/COX8A"]
["hsa05415","Diabetic cardiomyopathy","14/79","176/7675",{"v":2.25114703739869e-09,"d":"2.25E-09"},{"v":9.4548175570745e-08,"d":"9.45E-08"},{"v":7.22736680428e-08,"d":"7.23E-08"},"GAPDH/MPC2/COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/SLC25A5/COX5B/NDUFA13/UQCRH/COX4I1/COX8A"]
["hsa00190","Oxidative phosphorylation","11/79","105/7675",{"v":7.70108511867965e-09,"d":"7.70E-09"},{"v":2.58756459987636e-07,"d":"2.59E-07"},{"v":1.97796291469246e-07,"d":"1.98E-07"},"COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/COX5B/NDUFA13/UQCRH/COX4I1/COX8A"]
["hsa05010","Alzheimer disease","18/79","356/7675",{"v":1.32422353521992e-08,"d":"1.32E-08"},{"v":3.70782589861577e-07,"d":"3.71E-07"},{"v":2.83430300520755e-07,"d":"2.83E-07"},"GAPDH/APOE/COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/TUBA1B/SLC25A5/CALM2/PSMA7/COX5B/NDUFA13/UQCRH/COX4I1/TUBB/COX8A"]
["hsa04612","Antigen processing and presentation","9/79","68/7675",{"v":2.45805773386005e-08,"d":"2.46E-08"},{"v":5.89933856126411e-07,"d":"5.90E-07"},{"v":4.50951945159287e-07,"d":"4.51E-07"},"HSPA1A/HSP90AB1/HSP90AA1/HSPA1B/HLA-A/B2M/HLA-C/CALR/HSPA8"]
["hsa04714","Thermogenesis","13/79","193/7675",{"v":6.61458021989615e-08,"d":"6.61E-08"},{"v":1.35164975571547e-06,"d":"1.35E-06"},{"v":1.03321597867974e-06,"d":"1.03E-06"},"ACTB/COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/ACTG1/COX6B1/COX5B/NDUFA13/UQCRH/COX4I1/COX8A"]
["hsa05022","Pathways of neurodegeneration - multiple diseases","19/79","444/7675",{"v":7.24098083419001e-08,"d":"7.24E-08"},{"v":1.35164975571547e-06,"d":"1.35E-06"},{"v":1.03321597867974e-06,"d":"1.03E-06"},"UBB/UBA52/UBC/COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/TUBA1B/SLC25A5/CALM2/PSMA7/COX5B/NDUFA13/UQCRH/COX4I1/TUBB/COX8A"]
["hsa05016","Huntington disease","15/79","279/7675",{"v":1.1664968320435e-07,"d":"1.17E-07"},{"v":1.95971467783307e-06,"d":"1.96E-06"},{"v":1.49802751062428e-06,"d":"1.50E-06"},"COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/TUBA1B/SLC25A5/PSMA7/COX5B/NDUFA13/UQCRH/COX4I1/TUBB/COX8A"]
["hsa05014","Amyotrophic lateral sclerosis","16/79","334/7675",{"v":2.04760243004087e-07,"d":"2.05E-07"},{"v":3.12724734769879e-06,"d":"3.13E-06"},{"v":2.39050235851662e-06,"d":"2.39E-06"},"ACTB/COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/ACTG1/COX6B1/TUBA1B/PSMA7/COX5B/NDUFA13/UQCRH/COX4I1/TUBB/COX8A"]
["hsa04932","Non-alcoholic fatty liver disease","11/79","150/7675",{"v":3.17809014045515e-07,"d":"3.18E-07"},{"v":4.44932619663721e-06,"d":"4.45E-06"},{"v":3.40111400996077e-06,"d":"3.40E-06"},"COX6A1/NDUFC2/NDUFA4/COX6C/UQCRB/COX6B1/COX5B/NDUFA13/UQCRH/COX4I1/COX8A"]
["hsa05132","Salmonella infection","13/79","247/7675",{"v":1.15328677633839e-06,"d":"1.15E-06"},{"v":1.49040137249885e-05,"d":"1.49E-05"},{"v":1.13927924464198e-05,"d":"1.14E-05"},"HSP90AB1/GAPDH/HSP90AA1/S100A10/ACTB/TXN/DYNLL1/MYL12B/ACTG1/TUBA1B/MYL12A/TUBB/ARPC3"]
["hsa04260","Cardiac muscle contraction","8/79","83/7675",{"v":1.86031407276408e-06,"d":"1.86E-06"},{"v":2.2323768873169e-05,"d":"2.23E-05"},{"v":1.70645351035502e-05,"d":"1.71E-05"},"COX6A1/COX6C/UQCRB/COX6B1/COX5B/UQCRH/COX4I1/COX8A"]
["hsa05134","Legionellosis","6/79","56/7675",{"v":2.11610577972258e-05,"d":"2.12E-05"},0.000237003847328929,0.000181168354474494,"HSPA1A/EEF1A1/HSPA1B/EEF1G/HSPA8/HSPD1"]
["hsa05418","Fluid shear stress and atherosclerosis","8/79","136/7675",{"v":7.16099205774434e-05,"d":"7.16E-05"},0.000751904166063156,0.000574763836213691,"HSP90AB1/HSP90AA1/ACTB/TXN/GSTA1/SUMO2/ACTG1/CALM2"]
["hsa04145","Phagosome","8/79","148/7675",0.000129775142254974,0.00128248375875504,0.00098034472787039,"ACTB/HLA-A/HLA-C/ACTG1/TUBA1B/CALR/TUBB/SEC61B"]
["hsa04217","Necroptosis","7/79","122/7675",0.000242559085825374,0.00223423674726979,0.00170787520781275,"FTL/FTH1/HSP90AB1/HSP90AA1/PPIA/GLUL/SLC25A5"]
["hsa04141","Protein processing in endoplasmic reticulum","8/79","163/7675",0.000252681536893608,0.00223423674726979,0.00170787520781275,"HSPA1A/HSP90AB1/HSP90AA1/HSPA1B/CALR/HSPA8/SEC61B/DNAJB1"]
["hsa04915","Estrogen signaling pathway","7/79","134/7675",0.000430657679149122,0.00361752450485263,0.00276527562401015,"HSPA1A/HSP90AB1/HSP90AA1/HSPA1B/KRT18/CALM2/HSPA8"]
["hsa04814","Motor proteins","8/79","185/7675",0.000592443628253925,0.0047395490260314,0.00362296354120195,"ACTB/DYNLL1/MYL6/MYL12B/ACTG1/TUBA1B/MYL12A/TUBB"]
["hsa05131","Shigellosis","8/79","213/7675",0.00148174730075299,0.011173049548548,0.00854080228648403,"ACTB/UBB/UBA52/UBC/MYL12B/ACTG1/MYL12A/ARPC3"]
["hsa04530","Tight junction","7/79","166/7675",0.00152964368819407,0.011173049548548,0.00854080228648403,"ACTB/MYL6/MYL12B/ACTG1/TUBA1B/MYL12A/ARPC3"]
["hsa04979","Cholesterol metabolism","4/79","50/7675",0.00167221222953267,0.0117054856067287,0.00894780228083273,"APOA2/APOE/APOC2/APOC1"]
["hsa05416","Viral myocarditis","4/79","64/7675",0.00413891096995216,0.0278134817180785,0.0212609321403858,"ACTB/HLA-A/HLA-C/ACTG1"]
["hsa05417","Lipid and atherosclerosis","7/79","206/7675",0.005123308282634,0.0331044535185582,0.0253054093312287,"HSPA1A/HSP90AB1/HSP90AA1/HSPA1B/CALM2/HSPA8/HSPD1"]
["hsa04810","Regulation of actin cytoskeleton","7/79","224/7675",0.00801599477821209,0.0489415241448656,0.037411440762366,"ACTB/MYL12B/TMSB4X/CFL1/ACTG1/MYL12A/ARPC3"]
["hsa04216","Ferroptosis","3/79","41/7675",0.00844823928691133,0.0489415241448656,0.037411440762366,"FTL/FTH1/GPX4"]
["hsa04940","Type I diabetes mellitus","3/79","41/7675",0.00844823928691133,0.0489415241448656,0.037411440762366,"HLA-A/HLA-C/HSPD1"]

{"sheet":"Supplementary Table 3","index":3,"n_rows":115,"n_cols":7,"rows_kept":115,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
["Supplementary Table 3. Ranks of genes in HepScope gene set based on Log2FC. "]
["Rank","feature","avgExpr","logFC","auc","pval","padj"]
[1,"HSPA1A",2.31210655,1.53878173,0.76679492,0,0]
[2,"FTL",4.98373555,1.5034502,0.68234517,0,0]
[3,"APOA2",4.93489472,1.48044876,0.68298438,0,0]
[4,"FTH1",3.93553203,1.40681941,0.70206742,0,0]
[5,"HSPB1",2.17180435,1.39950154,0.77321453,0,0]
[6,"HSP90AB1",2.32545947,1.27907096,0.7625148,0,0]
[7,"GAPDH",2.85789241,1.27184951,0.72493114,0,0]
[8,"PTMA",2.90085577,1.25764253,0.7510906,0,0]
[9,"H3F3A",2.31344925,1.17898729,0.74902235,0,0]
[10,"APOE",3.7357086,1.16514921,0.66138635,{"v":1.49e-290,"d":"1.49E-290"},{"v":1.96e-288,"d":"1.96E-288"}]
[11,"APOC2",3.45538069,1.13172257,0.65833415,{"v":2.88e-280,"d":"2.88E-280"},{"v":3.42e-278,"d":"3.42E-278"}]
[12,"NACA",2.44839502,1.12933379,0.73838692,0,0]
[13,"HSP90AA1",2.71272207,1.10286546,0.72007273,0,0]
[14,"AKR1C3",1.65172777,1.07797171,0.73148111,0,0]
[15,"FAU",2.5339731,1.04282437,0.70514094,0,0]
[16,"S100A10",1.60152427,1.0187644,0.71272268,0,0]
[17,"EEF1A1",3.45135037,1.01170988,0.70900718,0,0]
[18,"PPIA",2.14049669,0.97860869,0.70993821,0,0]
[19,"ACTB",2.82229354,0.97292611,0.704225,0,0]
[20,"RBP4",3.48739113,0.97059197,0.63224834,{"v":2.03e-195,"d":"2.03E-195"},{"v":1.03e-193,"d":"1.03E-193"}]
[21,"TXN",1.98259989,0.9647248,0.69966516,0,0]
[22,"RARRES2",2.50292215,0.96340919,0.68153937,0,0]
[23,"PRDX1",1.93329478,0.95754781,0.70682114,0,0]
[24,"MPC2",1.85042356,0.94791394,0.70450993,0,0]
[25,"AMBP",3.4826026,0.94575958,0.64198855,{"v":9.46e-225,"d":"9.46E-225"},{"v":6.39e-223,"d":"6.39E-223"}]
[26,"IFI27",1.32396649,0.94269406,0.65784566,0,0]
[27,"H3F3B",2.08254438,0.94103619,0.69992267,0,0]
[28,"UBB",2.38943278,0.93604402,0.70092922,0,0]
[29,"EIF1",2.65996563,0.9280685,0.68300411,0,0]
[30,"SRP14",1.86040316,0.92613752,0.71498668,0,0]
[31,"TMSB10",2.03004309,0.92399399,0.6802421,0,0]
[32,"HSPA1B",1.37840004,0.92168434,0.68995321,0,0]
[33,"SERF2",2.67840688,0.92114279,0.6709363,0,0]
[34,"APOC1",4.2380166,0.90942661,0.59218585,{"v":8.23e-96,"d":"8.23E-96"},{"v":1.36e-94,"d":"1.36E-94"}]
[35,"HLA-A",2.04113582,0.90261679,0.68368223,0,0]
[36,"UBA52",2.43209644,0.90125249,0.69118427,0,0]
[37,"IFITM3",2.50084214,0.89877723,0.67830047,0,0]
[38,"CD63",1.7878259,0.88094531,0.69180514,0,0]
[39,"UBC",2.21110668,0.8754159,0.68802733,0,0]
[40,"GPC3",1.02903258,0.86438289,0.70123424,0,0]
[41,"DYNLL1",1.49569441,0.86314839,0.70887024,0,0]
[42,"MYL6",2.11806611,0.85675069,0.69312427,0,0]
[43,"PEBP1",2.58721199,0.85652603,0.67826346,0,0]
[44,"HSPE1",2.06338215,0.85462536,0.69482593,0,0]
[45,"COX6A1",1.78062744,0.85027297,0.68268257,0,0]
[46,"GLUL",1.40710118,0.83104602,0.66376861,0,0]
[47,"GSTA1",2.0958716,0.82623761,0.64106791,{"v":6.76e-230,"d":"6.76E-230"},{"v":4.93e-228,"d":"4.93E-228"}]
[48,"CHCHD2",1.75331233,0.82544663,0.6913931,0,0]
[49,"MYL12B",1.50231557,0.82514849,0.70417254,0,0]
[50,"TMSB4X",2.43480162,0.8155677,0.64678174,{"v":1.87e-241,"d":"1.87E-241"},{"v":1.56e-239,"d":"1.56E-239"}]
[51,"EPHX1",1.76604753,0.81225433,0.66612644,0,0]
[52,"PPIB",1.61427309,0.80312711,0.68394162,0,0]
[53,"CFL1",1.56779109,0.80148296,0.69451916,0,0]
[54,"RACK1",2.04557918,0.80127397,0.67656945,0,0]
[55,"SUB1",1.56039195,0.79979536,0.69662135,0,0]
[56,"B2M",3.42460227,0.7945824,0.63690256,{"v":7.12e-209,"d":"7.12E-209"},{"v":4.12e-207,"d":"4.12E-207"}]
[57,"NDUFC2",1.61771456,0.78737063,0.69042313,0,0]
[58,"NME2",1.66192393,0.78399765,0.68148326,0,0]
[59,"NDUFA4",2.06031759,0.77834866,0.66012275,{"v":1.67e-289,"d":"1.67E-289"},{"v":2.19e-287,"d":"2.19E-287"}]
[60,"TPT1",3.23245072,0.77546937,0.6468948,{"v":2.24e-240,"d":"2.24E-240"},{"v":1.83e-238,"d":"1.83E-238"}]
[61,"HINT1",2.28128379,0.77018297,0.64771161,{"v":4.06e-245,"d":"4.06E-245"},{"v":3.48e-243,"d":"3.48E-243"}]
[62,"KRT18",1.6686214,0.77018065,0.68011691,0,0]
[63,"EEF1G",1.9134208,0.76988511,0.67445431,0,0]
[64,"TPI1",1.53706927,0.76764746,0.67861199,0,0]
[65,"SUMO2",1.41977009,0.766968,0.6914976,0,0]
[66,"COX6C",1.97864199,0.75285508,0.65558697,{"v":6.17e-274,"d":"6.17E-274"},{"v":6.94e-272,"d":"6.94E-272"}]
[67,"VTN",3.34715678,0.74497049,0.65432094,{"v":2.57e-265,"d":"2.57E-265"},{"v":2.68e-263,"d":"2.68E-263"}]
[68,"HLA-C",1.81891621,0.74367616,0.65815098,{"v":2.2e-286,"d":"2.20E-286"},{"v":2.75e-284,"d":"2.75E-284"}]
[69,"UQCRB",1.86275993,0.74169446,0.66763937,0,0]
[70,"ACTG1",1.85882275,0.74103204,0.66733224,0,0]
[71,"BTF3",1.5423124,0.74008199,0.67927553,0,0]
[72,"ATP5G2",1.60458439,0.7287787,0.67475216,0,0]
[73,"NPM1",1.48819117,0.72173718,0.67197646,0,0]
[74,"COX6B1",1.71644541,0.71932656,0.66427671,{"v":9.35e-308,"d":"9.35E-308"},{"v":1.3e-305,"d":"1.30E-305"}]
[75,"TUBA1B",1.03251004,0.71057119,0.67721271,0,0]
[76,"SLC25A5",1.371312,0.70966846,0.67419753,0,0]
[77,"CALR",1.56440182,0.70872785,0.66864074,0,0]
[78,"TMEM176B",1.91535411,0.69993271,0.6564684,{"v":6.23e-279,"d":"6.23E-279"},{"v":7.21e-277,"d":"7.21E-277"}]
[79,"CALM2",1.5930315,0.69723883,0.67103368,0,0]
[80,"PSMA7",1.53487991,0.69498311,0.66998304,0,0]
[81,"NUPR1",1.67857355,0.6889608,0.64470765,{"v":2.29e-242,"d":"2.29E-242"},{"v":1.92e-240,"d":"1.92E-240"}]
[82,"PTGES3",1.27404723,0.68563347,0.68335636,0,0]
[83,"PRAP1",1.65043642,0.68254423,0.64097115,{"v":4.74e-233,"d":"4.74E-233"},{"v":3.6e-231,"d":"3.60E-231"}]
[84,"KRT8",1.37317463,0.67972889,0.66818902,0,0]
[85,"GPX4",1.81951182,0.67878052,0.64881945,{"v":9.01e-252,"d":"9.01E-252"},{"v":8.32e-250,"d":"8.32E-250"}]
[86,"HSPA8",1.40356529,0.67679454,0.66589256,0,0]
[87,"COX5B",1.68563437,0.66778749,0.65055861,{"v":2.03e-259,"d":"2.03E-259"},{"v":2.04e-257,"d":"2.04E-257"}]
[88,"ATP5B",1.27564302,0.66058877,0.67399301,0,0]
[89,"SEPP1",2.66440039,0.65704357,0.63730179,{"v":6.49e-211,"d":"6.49E-211"},{"v":3.83e-209,"d":"3.83E-209"}]
[90,"EEF1B2",1.59577568,0.65672281,0.6495352,{"v":6.4e-259,"d":"6.40E-259"},{"v":6.33e-257,"d":"6.33E-257"}]
[91,"MIF",2.01283038,0.65302624,0.62680243,{"v":1.35e-184,"d":"1.35E-184"},{"v":6.29e-183,"d":"6.29E-183"}]
[92,"NDUFA13",1.47356201,0.64717205,0.66344425,0,0]
[93,"MYL12A",1.22841444,0.64594132,0.67085562,0,0]
[94,"SLC25A3",1.39080756,0.64345555,0.66936225,0,0]
[95,"HMGN2",1.20047956,0.6373491,0.66021716,{"v":6.37e-308,"d":"6.37E-308"},{"v":8.96e-306,"d":"8.96E-306"}]
[96,"PRDX5",1.25858471,0.63553746,0.66862676,0,0]
[97,"ATP5C1",1.14650315,0.63528007,0.67412233,0,0]
[98,"UQCRH",1.43317029,0.63448332,0.65705063,{"v":1.54e-286,"d":"1.54E-286"},{"v":1.93e-284,"d":"1.93E-284"}]
[99,"COX4I1",1.77100836,0.6314295,0.6450067,{"v":3.32e-239,"d":"3.32E-239"},{"v":2.7e-237,"d":"2.70E-237"}]
[100,"CCT3",0.95237336,0.62991425,0.68281594,0,0]
[101,"RAN",1.03039227,0.62876732,0.67764591,0,0]
[102,"KRTCAP2",1.39449968,0.62776,0.65638121,{"v":2.5e-286,"d":"2.50E-286"},{"v":3.1e-284,"d":"3.10E-284"}]
[103,"TUBB",1.09901473,0.62303392,0.65297344,{"v":6.19e-288,"d":"6.19E-288"},{"v":7.94e-286,"d":"7.94E-286"}]
[104,"LGALS4",0.99800623,0.6228638,0.64170605,{"v":9.76e-269,"d":"9.76E-269"},{"v":1.04e-266,"d":"1.04E-266"}]
[105,"CFHR1",1.60350183,0.62181773,0.62964519,{"v":5.02e-199,"d":"5.02E-199"},{"v":2.62e-197,"d":"2.62E-197"}]
[106,"COX8A",1.42615915,0.61902714,0.64943069,{"v":7.66e-260,"d":"7.66E-260"},{"v":7.78e-258,"d":"7.78E-258"}]
[107,"SEC61B",1.45184234,0.61606408,0.65294422,{"v":3.36e-271,"d":"3.36E-271"},{"v":3.67e-269,"d":"3.67E-269"}]
[108,"DNAJB1",1.21728432,0.61594848,0.64769623,{"v":3.23e-267,"d":"3.23E-267"},{"v":3.41e-265,"d":"3.41E-265"}]
[109,"CLIC1",0.90710822,0.61517592,0.6735005,0,0]
[110,"HSPD1",1.73733905,0.6109909,0.64136181,{"v":1.07e-228,"d":"1.07E-228"},{"v":7.69e-227,"d":"7.69E-227"}]
[111,"ALDH1A1",1.46208486,0.60644841,0.63831268,{"v":5.92e-225,"d":"5.92E-225"},{"v":4.01e-223,"d":"4.01E-223"}]
[112,"ARPC3",1.10625126,0.60115228,0.67183629,0,0]
[113,"CUTA",1.26597454,0.60008976,0.65601,{"v":4.87e-287,"d":"4.87E-287"},{"v":6.17e-285,"d":"6.17E-285"}]

{"sheet":"Supplementary Table 4","index":4,"n_rows":39,"n_cols":8,"rows_kept":39,"merged":[[0,0,0,7],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,2,4],[1,5,1,7],[3,0,3,7],[4,0,14,0],[4,3,13,3],[16,0,16,7],[17,0,38,0],[17,3,37,3]],"flags":["formulas_cached_only"]}
["Supplementary Table 4. Description of RNA-seq datasets. "]
["Download source","Repository","Dataset (Web link)","Tissue","Total no. of included cells/samples","Distribution of included cells/samples"]
[{"$nulls":5},"Normal","ADJ_HCC","HCC"]
["scRNA-seq"]
["GepLiver","NCBI GEO","GSE115469","Liver",1382,1382,0,0]
[null,"NCBI GEO","GSE136103",null,42,42,0,0]
[null,"NCBI GEO","GSE156625",null,7139,0,49,7090]
[null,"NCBI GEO","GSE159977",null,22,22,0,0]
[null,"NCBI GEO","GSE168933",null,269,269,0,0]
[null,"NCBI GEO","GSE174748",null,1349,1349,0,0]
[null,"NCBI GEO","GSE186328",null,66,66,0,0]
[null,"NCBI GEO","GSE192740",null,405,405,0,0]
[null,"National Genomics Data Center","HRA001748",null,19498,0,421,19077]
[null,"NCBI SRA","SRP318499",null,4268,0,0,4268]
[null,null,"Total",null,34440,3535,470,30435]
["scAtlas","NCBI GEO","GSE151530",null,13769,0,0,13769]
["Bulk RNA-seq"]
["GepLiver","NCBI GEO","GSE112221","Liver",10,2,4,4]
[null,"NCBI GEO","GSE114564",null,78,15,0,63]
[null,"NCBI GEO","GSE124535",null,70,0,35,35]
[null,"NCBI GEO","GSE126848",null,26,26,0,0]
[null,"NCBI GEO","GSE130970",null,4,4,0,0]
[null,"NCBI GEO","GSE135251",null,10,10,0,0]
[null,"NCBI GEO","GSE140462",null,14,0,7,7]
[null,"NCBI GEO","GSE142530",null,12,12,0,0]
[null,"NCBI GEO","GSE143318",null,5,5,0,0]
[null,"NCBI GEO","GSE144269",null,140,0,70,70]
[null,"NCBI GEO","GSE148355",null,74,15,1,58]
[null,"NCBI GEO","GSE155907",null,4,4,0,0]
[null,"NCBI GEO","GSE162694",null,31,31,0,0]
[null,"NCBI GEO","GSE77314",null,100,0,50,50]
[null,"NCBI GEO","GSE77509",null,38,0,19,19]
[null,"NCBI GEO","GSE81928",null,3,3,0,0]
[null,"NCBI GEO","GSE84346",null,6,6,0,0]
[null,"NCBI GEO","GSE89775",null,3,3,0,0]
[null,"NCBI GEO","GSE94660",null,42,0,21,21]
[null,"GTEx","GTEx",null,226,226,0,0]
[null,"TCGA","TCGA-LIHC",null,413,0,49,364]
[null,null,"Total",null,1309,362,256,691]

{"sheet":"Supplementary Table 5","index":5,"n_rows":6,"n_cols":9,"rows_kept":6,"merged":[[0,0,0,8],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,2,4],[1,5,2,5],[1,6,1,8],[3,4,5,4]],"flags":["formulas_cached_only"]}
["Supplementary Table 5. Description of stRNA-seq datasets. "]
["Download source","Repository","Dataset (Web link)","Technology","Tissue type","Total no. of tissue samples","Distribution of included cells/samples"]
[{"$nulls":6},"Normal","ADJ_HCC","HCC"]
["nanoString","nanoString","CosMx SMI Human Liver FFPE Dataset","CosMx","Liver",2,1,0,1]
["Genome Sequence Archive","National Genomics Data Center","HRA000437","Visium 10X",null,8,0,4,4]
["Mendeley Data","Mendeley Data","skrx2fz79n","Visium 10X",null,4,0,0,4]

{"sheet":"Supplementary Table 6","index":6,"n_rows":9,"n_cols":5,"rows_kept":9,"merged":[[0,0,0,4]],"flags":["formulas_cached_only"]}
["Supplementary Table 6. Description of the 5 publicly available HCC related gene set used in this study. "]
["Name of gene set","no. of genes","*no. of used genes","Tissue comparisons","Description"]
["ACEVEDO_LIVER_CANCER_UP",972,944,"HCC vs Normal liver","Genes up-regulated in HCC compared to normal liver samples."]
["ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP",863,837,"HCC vs ADJ_HCC","Genes up-regulated in liver tumor compared to the normal adjacent tissue."]
["MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER",55,44,"HCC vs peripheral blood lymphocytes","Genes found to have genomic amplification in HCC compared to peripheral blood lymphocytes"]
["PATIL_LIVER_CANCER",660,636,"HCC vs Normal liver","Genes up-regulated in HCC compared to normal liver samples."]
["SMITH_LIVER_CANCER",47,47,"HCC vs cirrhotic ADJ_HCC","Genes up-regulated in HCC compared to  adjacent non-tumor tissue that was cirrhotic in all of the cases."]
[]
["*no. of used genes = The number of genes which is used for scRNA-seq, AI tasks"]

{"sheet":"TableS7","index":7,"n_rows":39,"n_cols":11,"rows_kept":39,"hidden":true,"merged":[[0,0,0,10],[1,2,1,5],[1,7,1,10],[2,0,3,1],[2,2,3,2],[2,3,2,4],[2,5,3,5],[2,7,3,7],[2,8,2,9],[2,10,3,10],[10,2,10,5],[10,7,10,10]],"flags":["formulas_cached_only"]}
["Table S7: Univariate and multivariate Cox Regression Analyses of clinical factors and HepScope risk score for HCC patients."]
[null,null,"Univariate",{"$nulls":4},"Multivariate"]
["Variable",null,"HR","95% CI",null,"log-rank,p",null,"HR","95% CI",null,"log-rank, p"]
[{"$nulls":3},"Lower","Upper",{"$nulls":3},"Lower","Upper"]
["Age(y/o)"]
[null,">=70","Reference",{"$nulls":4},"Reference"]
[null,"2024-01-17",0,0,"Inf",1,null,0,0,"Inf",">0.9"]
[null,"18-49",0.5,0.3,0.84,"0.03*",null,0.59,0.34,1.02,0.06]
[null,"50-69",0.62,0.42,0.91,"0.04*",null,0.77,0.5,1.18,0.2]
["Sex"]
[null,"Female","Reference",{"$nulls":4},"Reference"]
[null,"Male",0.7,0.49,0.99,"0.04*",null,0.89,0.61,1.31,0.6]
["Tumour grade"]
[null,"G1","Reference"]
[null,"G2",1.31,0.77,2.21,0.31]
[null,"G3",1.53,0.89,2.63,0.13]
[null,"G4",1.88,0.63,5.57,0.26]
["AJCC stage"]
[null,"I","Reference",{"$nulls":4},"Reference"]
[null,"II",1.01,0.62,1.62,1,null,0.64,0.13,3.17,0.6]
[null,"III",2.39,1.57,3.64,"<0.01*",null,0.46,0.05,4.01,0.5]
[null,"IV",2.2,0.93,5.19,0.07,null,0.42,0.04,4.16,0.5]
["T stage"]
[null,"T1","Reference",{"$nulls":4},"Reference"]
[null,"T2",1.49,0.94,2.37,0.09,null,1.92,0.38,9.77,0.4]
[null,"T3",2.63,1.73,4,"<0.01*",null,4.81,0.54,42.9,0.2]
[null,"T4",5.29,2.64,10.6,"<0.01*",null,10.2,1.05,99.4,0.5]
[null,"TX",0.23,0.1,0.53,"<0.01*",null,0.37,0.09,1.47,0.2]
["N stage"]
[null,"N0","Reference",{"$nulls":4},"Reference"]
[null,"N1",2.62,0.64,10.7,0.18,null,2.06,0.2,21.6,0.5]
[null,"NX",1.72,1.19,2.48,"<0.01*",null,1.03,0.61,1.73,">0.9"]
["M stage"]
[null,"M0","Reference",{"$nulls":4},"Reference"]
[null,"M1",1.58,0.58,4.33,0.37,null,0.49,0.05,5.11,0.5]
[null,"MX",1.71,1.18,2.48,"<0.01*",null,1.55,0.92,2.64,0.1]
["HepScope Risk"]
[null,"Low","Reference",{"$nulls":4},"Reference"]
[null,"High",3.28,2.33,4.63,"<0.01*",null,2.98,2.03,4.37,"<0.01*"]