Supplementary Data: CDS annotation for each MGE used in the Synteny analysis (Supplementary Figure S5) Plasmid-1 (H4301R1_000000002678) Gene ID MGE start end orientation annotation 9542 H4301R1_000000002678 1 1240 r COG14_FUNCTION COG3505 Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase 1.9e-152 9543 H4301R1_000000002678 1254 2271 r COG14_FUNCTION COG0630 Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase 2e-160 9544 H4301R1_000000002678 2274 3537 r COG14_FUNCTION COG2948 Type IV secretory pathway, VirB10 components 3.3e-144 9545 H4301R1_000000002678 3538 4549 r COG14_FUNCTION COG3504 Type IV secretory pathway, VirB9 components 2.4e-121 9546 H4301R1_000000002678 4550 5228 r COG14_FUNCTION COG3736 Type IV secretory pathway, component VirB8 1e-88 9548 H4301R1_000000002678 5663 6716 r COG14_FUNCTION COG3704 Type IV secretory pathway, VirB6 components 7.5e-118 9551 H4301R1_000000002678 7714 10081 r COG14_FUNCTION COG3451 Type IV secretory pathway, VirB4 component 0 9552 H4301R1_000000002678 10073 10409 r COG14_FUNCTION COG3702 Type IV secretory pathway, VirB3 components 8.9e-49 9554 H4301R1_000000002678 10740 12345 r COG14_FUNCTION COG3843 Type IV secretory pathway, VirD2 components (relaxase) 4.9e-20 9555 H4301R1_000000002678 12341 12938 r COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 1.5e-59 9557 H4301R1_000000002678 13278 14082 r COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 7.4e-25 9551 H4301R1_000000002678 7714 10081 r Pfam PF03135.14 CagE, TrbE, VirB family, component of type IV transporter system 4.8e-43 9545 H4301R1_000000002678 3538 4549 r Pfam PF03524.15 Conjugal transfer protein 5.3e-60 9554 H4301R1_000000002678 10740 12345 r Pfam PF18821.1 Large polyvalent protein-associated domain 7 5.1e-21 9555 H4301R1_000000002678 12341 12938 r Pfam PF01464.20 Transglycosylase SLT domain 5.4e-16 9543 H4301R1_000000002678 1254 2271 r Pfam PF00437.20 Type II/IV secretion system protein 1.4e-62 9550 H4301R1_000000002678 6989 7715 r Pfam PF07996.11 Type IV secretion system proteins 1.4e-44 9542 H4301R1_000000002678 1 1240 r Pfam PF02534.14 Type IV secretory system Conjugative DNA transfer 5e-62 9555 H4301R1_000000002678 12341 12938 r Pfam PF06871.11 TraH_2 9.3e-08 9553 H4301R1_000000002678 10415 10733 r Pfam PF04956.13 TrbC/VIRB2 family 8e-19 9544 H4301R1_000000002678 2274 3537 r Pfam PF03743.14 Bacterial conjugation TrbI-like protein 3.1e-50 9548 H4301R1_000000002678 5663 6716 r Pfam PF04610.14 TrbL/VirB6 plasmid conjugal transfer protein 8.4e-29 9552 H4301R1_000000002678 10073 10409 r Pfam PF05101.13 Type IV secretory pathway, VirB3-like protein 4.6e-22 9546 H4301R1_000000002678 4550 5228 r Pfam PF04335.13 VirB8 protein 3.2e-58 9552 H4301R1_000000002678 10073 10409 r KOfam K03198 type IV secretion system protein VirB3 4e-30 9542 H4301R1_000000002678 1 1240 r KOfam K03205 type IV secretion system protein VirD4 [EC:7.4.2.8] 2.1e-100 9545 H4301R1_000000002678 3538 4549 r KOfam K03204 type IV secretion system protein VirB9 9e-100 9551 H4301R1_000000002678 7714 10081 r KOfam K03199 type IV secretion system protein VirB4 [EC:7.4.2.8] 0 9550 H4301R1_000000002678 6989 7715 r KOfam K03200 type IV secretion system protein VirB5 8.6e-35 9548 H4301R1_000000002678 5663 6716 r KOfam K03201 type IV secretion system protein VirB6 2.8e-33 9546 H4301R1_000000002678 4550 5228 r KOfam K03203 type IV secretion system protein VirB8 2.9e-71 9547 H4301R1_000000002678 5244 5592 r KOfam K03202 type IV secretion system protein VirB7 3.3e-07 9555 H4301R1_000000002678 12341 12938 r KOfam K03194 type IV secretion system protein VirB1 7.9e-53 9544 H4301R1_000000002678 2274 3537 r KOfam K03195 type IV secretion system protein VirB10 3.1e-95 9553 H4301R1_000000002678 10415 10733 r KOfam K03197 type IV secretion system protein VirB2 3.4e-25 9543 H4301R1_000000002678 1254 2271 r KOfam K03196 type IV secretion system protein VirB11 [EC:7.4.2.8] 2.6e-124 9557 H4301R1_000000002678 13278 14082 r KOfam K03194 type IV secretion system protein VirB1 4.6e-15 9542 H4301R1_000000002678 1 1240 r EGGNOG_BACT 1112214.AHIS01000142_gene3380 TraM recognition site of TraD and TraG 2.92e-211 9542 H4301R1_000000002678 1 1240 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3380 U 2.92e-211 9543 H4301R1_000000002678 1254 2271 r EGGNOG_BACT 1112214.AHIS01000142_gene3381 Type IV secretion protein VirB11 3.18e-221 9543 H4301R1_000000002678 1254 2271 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3381 NU 3.18e-221 9544 H4301R1_000000002678 2274 3537 r EGGNOG_BACT 1112214.AHIS01000142_gene3382 Bacterial conjugation TrbI-like protein 2.48e-192 9544 H4301R1_000000002678 2274 3537 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3382 U 2.48e-192 9545 H4301R1_000000002678 3538 4549 r EGGNOG_BACT 1112214.AHIS01000142_gene3383 virB9 :: Conjugal transfer protein trbG 2.77e-188 9545 H4301R1_000000002678 3538 4549 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3383 U 2.77e-188 9546 H4301R1_000000002678 4550 5228 r EGGNOG_BACT 1096930.L284_07015 Conjugal transfer protein TraJ 6.28e-130 9546 H4301R1_000000002678 4550 5228 r EGGNOG_COG_CATEGORY 1096930.L284_07015 U 6.28e-130 9548 H4301R1_000000002678 5663 6716 r EGGNOG_BACT 1096930.L284_07020 TrbL/VirB6 plasmid conjugal transfer protein 9.59e-198 9548 H4301R1_000000002678 5663 6716 r EGGNOG_COG_CATEGORY 1096930.L284_07020 U 9.59e-198 9550 H4301R1_000000002678 6989 7715 r EGGNOG_BACT 1096930.L284_07030 Type IV secretion system proteins 2.85e-101 9550 H4301R1_000000002678 6989 7715 r EGGNOG_COG_CATEGORY 1096930.L284_07030 S 2.85e-101 9551 H4301R1_000000002678 7714 10081 r EGGNOG_BACT 1096930.L284_07035 type IV secretion system 0 9551 H4301R1_000000002678 7714 10081 r EGGNOG_COG_CATEGORY 1096930.L284_07035 U 0 9552 H4301R1_000000002678 10073 10409 r EGGNOG_BACT 1096930.L284_07040 Type IV secretory pathway, VirB3-like protein 4.3e-68 9552 H4301R1_000000002678 10073 10409 r EGGNOG_COG_CATEGORY 1096930.L284_07040 U 4.3e-68 9553 H4301R1_000000002678 10415 10733 r EGGNOG_BACT 1096930.L284_07045 TrbC/VIRB2 family 5.01e-49 9553 H4301R1_000000002678 10415 10733 r EGGNOG_COG_CATEGORY 1096930.L284_07045 S 5.01e-49 9554 H4301R1_000000002678 10740 12345 r EGGNOG_BACT 1096930.L284_07050 relaxase mobilization nuclease domain protein 4.69e-90 9554 H4301R1_000000002678 10740 12345 r EGGNOG_COG_CATEGORY 1096930.L284_07050 U 4.69e-90 9555 H4301R1_000000002678 12341 12938 r EGGNOG_BACT 1096930.L284_07055 Transglycosylase SLT domain 1.59e-94 9555 H4301R1_000000002678 12341 12938 r EGGNOG_COG_CATEGORY 1096930.L284_07055 M 1.59e-94 9557 H4301R1_000000002678 13278 14082 r EGGNOG_BACT 1112214.AHIS01000142_gene3392 lytic transglycosylase activity 9.2e-117 9557 H4301R1_000000002678 13278 14082 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3392 M 9.2e-117 Plasmid-2 (H5101R2_000000001804) Gene ID MGE start end orientation annotation 322 H5101R2_000000001804 2151 2982 r COG14_FUNCTION COG5285 Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family 2.9e-40 324 H5101R2_000000001804 3769 5713 r COG14_FUNCTION COG3505 Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase 1.1e-212 325 H5101R2_000000001804 5727 6744 r COG14_FUNCTION COG0630 Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase 2e-160 326 H5101R2_000000001804 6747 8010 r COG14_FUNCTION COG2948 Type IV secretory pathway, VirB10 components 3.3e-144 327 H5101R2_000000001804 8011 9022 r COG14_FUNCTION COG3504 Type IV secretory pathway, VirB9 components 2.4e-121 328 H5101R2_000000001804 9023 9701 r COG14_FUNCTION COG3736 Type IV secretory pathway, component VirB8 1e-88 330 H5101R2_000000001804 10136 11189 r COG14_FUNCTION COG3704 Type IV secretory pathway, VirB6 components 7.5e-118 333 H5101R2_000000001804 12187 14554 r COG14_FUNCTION COG3451 Type IV secretory pathway, VirB4 component 0 334 H5101R2_000000001804 14550 14910 r COG14_FUNCTION COG3702 Type IV secretory pathway, VirB3 components 7.8e-43 336 H5101R2_000000001804 15241 16846 r COG14_FUNCTION COG3843 Type IV secretory pathway, VirD2 components (relaxase) 4.9e-20 337 H5101R2_000000001804 16842 17439 r COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 1.5e-59 339 H5101R2_000000001804 17779 18583 r COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 7.4e-25 340 H5101R2_000000001804 18823 19471 f COG14_FUNCTION COG1961 Site-specific DNA recombinase related to the DNA invertase Pin 8.1e-06 333 H5101R2_000000001804 12187 14554 r Pfam PF03135.14 CagE, TrbE, VirB family, component of type IV transporter system 2.5e-43 327 H5101R2_000000001804 8011 9022 r Pfam PF03524.15 Conjugal transfer protein 2.8e-60 340 H5101R2_000000001804 18823 19471 f Pfam PF13384.6 Homeodomain-like domain 1.3e-07 341 H5101R2_000000001804 19336 19600 r Pfam PF01381.22 Helix-turn-helix 8.3e-08 341 H5101R2_000000001804 19336 19600 r Pfam PF13560.6 Helix-turn-helix domain 1.3e-08 340 H5101R2_000000001804 18823 19471 f Pfam PF02796.15 Helix-turn-helix domain of resolvase 1.6e-08 336 H5101R2_000000001804 15241 16846 r Pfam PF18821.1 Large polyvalent protein-associated domain 7 2.6e-21 322 H5101R2_000000001804 2151 2982 r Pfam PF05721.13 Phytanoyl-CoA dioxygenase (PhyH) 4.1e-30 337 H5101R2_000000001804 16842 17439 r Pfam PF01464.20 Transglycosylase SLT domain 2.8e-16 325 H5101R2_000000001804 5727 6744 r Pfam PF00437.20 Type II/IV secretion system protein 7.2e-63 332 H5101R2_000000001804 11462 12188 r Pfam PF07996.11 Type IV secretion system proteins 7.4e-45 324 H5101R2_000000001804 3769 5713 r Pfam PF02534.14 Type IV secretory system Conjugative DNA transfer 4.4e-93 324 H5101R2_000000001804 3769 5713 r Pfam PF12696.7 TraM recognition site of TraD and TraG 2.4e-27 337 H5101R2_000000001804 16842 17439 r Pfam PF06871.11 TraH_2 4.8e-08 335 H5101R2_000000001804 14916 15234 r Pfam PF04956.13 TrbC/VIRB2 family 4.2e-19 326 H5101R2_000000001804 6747 8010 r Pfam PF03743.14 Bacterial conjugation TrbI-like protein 1.6e-50 330 H5101R2_000000001804 10136 11189 r Pfam PF04610.14 TrbL/VirB6 plasmid conjugal transfer protein 4.4e-29 324 H5101R2_000000001804 3769 5713 r Pfam PF10412.9 Type IV secretion-system coupling protein DNA-binding domain 3.5e-21 334 H5101R2_000000001804 14550 14910 r Pfam PF05101.13 Type IV secretory pathway, VirB3-like protein 3.1e-22 328 H5101R2_000000001804 9023 9701 r Pfam PF04335.13 VirB8 protein 1.6e-58 334 H5101R2_000000001804 14550 14910 r KOfam K03198 type IV secretion system protein VirB3 3e-30 324 H5101R2_000000001804 3769 5713 r KOfam K03205 type IV secretion system protein VirD4 [EC:7.4.2.8] 2.1e-145 327 H5101R2_000000001804 8011 9022 r KOfam K03204 type IV secretion system protein VirB9 4.7e-100 333 H5101R2_000000001804 12187 14554 r KOfam K03199 type IV secretion system protein VirB4 [EC:7.4.2.8] 0 332 H5101R2_000000001804 11462 12188 r KOfam K03200 type IV secretion system protein VirB5 4.5e-35 330 H5101R2_000000001804 10136 11189 r KOfam K03201 type IV secretion system protein VirB6 1.4e-33 328 H5101R2_000000001804 9023 9701 r KOfam K03203 type IV secretion system protein VirB8 1.5e-71 329 H5101R2_000000001804 9717 10065 r KOfam K03202 type IV secretion system protein VirB7 1.7e-07 337 H5101R2_000000001804 16842 17439 r KOfam K03194 type IV secretion system protein VirB1 4.1e-53 326 H5101R2_000000001804 6747 8010 r KOfam K03195 type IV secretion system protein VirB10 1.6e-95 335 H5101R2_000000001804 14916 15234 r KOfam K03197 type IV secretion system protein VirB2 1.8e-25 325 H5101R2_000000001804 5727 6744 r KOfam K03196 type IV secretion system protein VirB11 [EC:7.4.2.8] 1.3e-124 322 H5101R2_000000001804 2151 2982 r KOfam K00477 phytanoyl-CoA hydroxylase [EC:1.14.11.18] 6.9e-41 339 H5101R2_000000001804 17779 18583 r KOfam K03194 type IV secretion system protein VirB1 2.4e-15 322 H5101R2_000000001804 2151 2982 r EGGNOG_BACT 1120950.KB892758_gene6313 Phytanoyl-CoA dioxygenase (PhyH) 2.67e-56 322 H5101R2_000000001804 2151 2982 r EGGNOG_COG_CATEGORY 1120950.KB892758_gene6313 Q 2.67e-56 324 H5101R2_000000001804 3769 5713 r EGGNOG_BACT 1112214.AHIS01000142_gene3380 TraM recognition site of TraD and TraG 2.26e-306 324 H5101R2_000000001804 3769 5713 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3380 U 2.26e-306 325 H5101R2_000000001804 5727 6744 r EGGNOG_BACT 1112214.AHIS01000142_gene3381 Type IV secretion protein VirB11 3.18e-221 325 H5101R2_000000001804 5727 6744 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3381 NU 3.18e-221 326 H5101R2_000000001804 6747 8010 r EGGNOG_BACT 1112214.AHIS01000142_gene3382 Bacterial conjugation TrbI-like protein 2.48e-192 326 H5101R2_000000001804 6747 8010 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3382 U 2.48e-192 327 H5101R2_000000001804 8011 9022 r EGGNOG_BACT 1112214.AHIS01000142_gene3383 virB9 :: Conjugal transfer protein trbG 2.77e-188 327 H5101R2_000000001804 8011 9022 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3383 U 2.77e-188 328 H5101R2_000000001804 9023 9701 r EGGNOG_BACT 1096930.L284_07015 Conjugal transfer protein TraJ 6.28e-130 328 H5101R2_000000001804 9023 9701 r EGGNOG_COG_CATEGORY 1096930.L284_07015 U 6.28e-130 330 H5101R2_000000001804 10136 11189 r EGGNOG_BACT 1096930.L284_07020 TrbL/VirB6 plasmid conjugal transfer protein 9.59e-198 330 H5101R2_000000001804 10136 11189 r EGGNOG_COG_CATEGORY 1096930.L284_07020 U 9.59e-198 332 H5101R2_000000001804 11462 12188 r EGGNOG_BACT 1096930.L284_07030 Type IV secretion system proteins 2.85e-101 332 H5101R2_000000001804 11462 12188 r EGGNOG_COG_CATEGORY 1096930.L284_07030 S 2.85e-101 333 H5101R2_000000001804 12187 14554 r EGGNOG_BACT 1096930.L284_07035 type IV secretion system 0 333 H5101R2_000000001804 12187 14554 r EGGNOG_COG_CATEGORY 1096930.L284_07035 U 0 334 H5101R2_000000001804 14550 14910 r EGGNOG_BACT 1096930.L284_07040 Type IV secretory pathway, VirB3-like protein 3.06e-61 334 H5101R2_000000001804 14550 14910 r EGGNOG_COG_CATEGORY 1096930.L284_07040 U 3.06e-61 335 H5101R2_000000001804 14916 15234 r EGGNOG_BACT 1096930.L284_07045 TrbC/VIRB2 family 5.01e-49 335 H5101R2_000000001804 14916 15234 r EGGNOG_COG_CATEGORY 1096930.L284_07045 S 5.01e-49 336 H5101R2_000000001804 15241 16846 r EGGNOG_BACT 1096930.L284_07050 relaxase mobilization nuclease domain protein 4.69e-90 336 H5101R2_000000001804 15241 16846 r EGGNOG_COG_CATEGORY 1096930.L284_07050 U 4.69e-90 337 H5101R2_000000001804 16842 17439 r EGGNOG_BACT 1096930.L284_07055 Transglycosylase SLT domain 1.59e-94 337 H5101R2_000000001804 16842 17439 r EGGNOG_COG_CATEGORY 1096930.L284_07055 M 1.59e-94 339 H5101R2_000000001804 17779 18583 r EGGNOG_BACT 1112214.AHIS01000142_gene3392 lytic transglycosylase activity 9.2e-117 339 H5101R2_000000001804 17779 18583 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3392 M 9.2e-117 340 H5101R2_000000001804 18823 19471 f EGGNOG_BACT 1029824.AFID01000016_gene1155 Helix-turn-helix domain 2.1e-07 340 H5101R2_000000001804 18823 19471 f EGGNOG_COG_CATEGORY 1029824.AFID01000016_gene1155 L 2.1e-07 341 H5101R2_000000001804 19336 19600 r EGGNOG_BACT 1120983.KB894570_gene1760 MA20_09785 :: Helix-turn-helix XRE-family like proteins 0.000823 341 H5101R2_000000001804 19336 19600 r EGGNOG_COG_CATEGORY 1120983.KB894570_gene1760 K 0.000823 Plasmid-3 (H4301R3_000000001191) Gene ID MGE start end orientation annotation 7600 H4301R3_000000001191 136 940 f COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 7.4e-25 7602 H4301R3_000000001191 1280 1877 f COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 1.5e-59 7603 H4301R3_000000001191 1873 3478 f COG14_FUNCTION COG3843 Type IV secretory pathway, VirD2 components (relaxase) 4.9e-20 7605 H4301R3_000000001191 3809 4145 f COG14_FUNCTION COG3702 Type IV secretory pathway, VirB3 components 8.9e-49 7606 H4301R3_000000001191 4137 6504 f COG14_FUNCTION COG3451 Type IV secretory pathway, VirB4 component 0 7609 H4301R3_000000001191 7502 8555 f COG14_FUNCTION COG3704 Type IV secretory pathway, VirB6 components 7.5e-118 7611 H4301R3_000000001191 8990 9668 f COG14_FUNCTION COG3736 Type IV secretory pathway, component VirB8 1e-88 7612 H4301R3_000000001191 9669 10680 f COG14_FUNCTION COG3504 Type IV secretory pathway, VirB9 components 2.4e-121 7613 H4301R3_000000001191 10681 11944 f COG14_FUNCTION COG2948 Type IV secretory pathway, VirB10 components 3.3e-144 7614 H4301R3_000000001191 11947 12964 f COG14_FUNCTION COG0630 Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase 2e-160 7615 H4301R3_000000001191 12978 14922 f COG14_FUNCTION COG3505 Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase 1.1e-212 7617 H4301R3_000000001191 15709 16540 f COG14_FUNCTION COG5285 Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family 2.9e-40 7623 H4301R3_000000001191 19726 21367 f COG14_FUNCTION COG0367 Asparagine synthetase B (glutamine-hydrolyzing) 6.4e-31 7624 H4301R3_000000001191 21350 22883 f COG14_FUNCTION COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II 1.1e-29 7625 H4301R3_000000001191 22869 23583 f COG14_FUNCTION COG5285 Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family 4.6e-10 7628 H4301R3_000000001191 25044 25803 f COG14_FUNCTION COG2226 Ubiquinone/menaquinone biosynthesis C-methylase UbiE 1.2e-53 7629 H4301R3_000000001191 25799 27482 f COG14_FUNCTION COG0119 Isopropylmalate/homocitrate/citramalate synthases 6.4e-103 7630 H4301R3_000000001191 27501 28335 r COG14_FUNCTION COG3293 Transposase 2.6e-137 7626 H4301R3_000000001191 23579 24146 f Pfam PF02230.16 Phospholipase/Carboxylesterase 8.4e-10 7626 H4301R3_000000001191 23579 24146 f Pfam PF12697.7 Alpha/beta hydrolase family 6.7e-08 7622 H4301R3_000000001191 18651 19695 f Pfam PF08545.10 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 7e-08 7622 H4301R3_000000001191 18651 19695 f Pfam PF08541.10 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 6.4e-08 7624 H4301R3_000000001191 21350 22883 f Pfam PF00501.28 AMP-binding enzyme 4.3e-55 7624 H4301R3_000000001191 21350 22883 f Pfam PF13193.6 AMP-binding enzyme C-terminal domain 2.9e-07 7623 H4301R3_000000001191 19726 21367 f Pfam PF00733.21 Asparagine synthase 1e-29 7606 H4301R3_000000001191 4137 6504 f Pfam PF03135.14 CagE, TrbE, VirB family, component of type IV transporter system 4.8e-43 7612 H4301R3_000000001191 9669 10680 f Pfam PF03524.15 Conjugal transfer protein 5.3e-60 7630 H4301R3_000000001191 27501 28335 r Pfam PF01609.21 Transposase DDE domain 5.4e-30 7630 H4301R3_000000001191 27501 28335 r Pfam PF13586.6 Transposase DDE domain 2e-15 7626 H4301R3_000000001191 23579 24146 f Pfam PF01738.18 Dienelactone hydrolase family 5.4e-06 7630 H4301R3_000000001191 27501 28335 r Pfam PF13340.6 Putative transposase of IS4/5 family (DUF4096) 4.4e-26 7629 H4301R3_000000001191 25799 27482 f Pfam PF00682.19 HMGL-like 4.4e-61 7603 H4301R3_000000001191 1873 3478 f Pfam PF18821.1 Large polyvalent protein-associated domain 7 5.1e-21 7628 H4301R3_000000001191 25044 25803 f Pfam PF08241.12 Methyltransferase domain 1.5e-16 7628 H4301R3_000000001191 25044 25803 f Pfam PF13649.6 Methyltransferase domain 7.7e-13 7617 H4301R3_000000001191 15709 16540 f Pfam PF05721.13 Phytanoyl-CoA dioxygenase (PhyH) 7.8e-30 7625 H4301R3_000000001191 22869 23583 f Pfam PF05721.13 Phytanoyl-CoA dioxygenase (PhyH) 2.3e-26 7602 H4301R3_000000001191 1280 1877 f Pfam PF01464.20 Transglycosylase SLT domain 5.4e-16 7614 H4301R3_000000001191 11947 12964 f Pfam PF00437.20 Type II/IV secretion system protein 1.4e-62 7607 H4301R3_000000001191 6503 7229 f Pfam PF07996.11 Type IV secretion system proteins 1.4e-44 7615 H4301R3_000000001191 12978 14922 f Pfam PF02534.14 Type IV secretory system Conjugative DNA transfer 8.5e-93 7627 H4301R3_000000001191 24142 25033 f Pfam PF02668.16 Taurine catabolism dioxygenase TauD, TfdA family 2.6e-18 7615 H4301R3_000000001191 12978 14922 f Pfam PF12696.7 TraM recognition site of TraD and TraG 4.7e-27 7602 H4301R3_000000001191 1280 1877 f Pfam PF06871.11 TraH_2 9.3e-08 7604 H4301R3_000000001191 3485 3803 f Pfam PF04956.13 TrbC/VIRB2 family 8e-19 7613 H4301R3_000000001191 10681 11944 f Pfam PF03743.14 Bacterial conjugation TrbI-like protein 3.1e-50 7609 H4301R3_000000001191 7502 8555 f Pfam PF04610.14 TrbL/VirB6 plasmid conjugal transfer protein 8.4e-29 7615 H4301R3_000000001191 12978 14922 f Pfam PF10412.9 Type IV secretion-system coupling protein DNA-binding domain 6.8e-21 7605 H4301R3_000000001191 3809 4145 f Pfam PF05101.13 Type IV secretory pathway, VirB3-like protein 4.6e-22 7611 H4301R3_000000001191 8990 9668 f Pfam PF04335.13 VirB8 protein 3.2e-58 7605 H4301R3_000000001191 3809 4145 f KOfam K03198 type IV secretion system protein VirB3 4e-30 7615 H4301R3_000000001191 12978 14922 f KOfam K03205 type IV secretion system protein VirD4 [EC:7.4.2.8] 4e-145 7612 H4301R3_000000001191 9669 10680 f KOfam K03204 type IV secretion system protein VirB9 9e-100 7606 H4301R3_000000001191 4137 6504 f KOfam K03199 type IV secretion system protein VirB4 [EC:7.4.2.8] 0 7607 H4301R3_000000001191 6503 7229 f KOfam K03200 type IV secretion system protein VirB5 8.6e-35 7609 H4301R3_000000001191 7502 8555 f KOfam K03201 type IV secretion system protein VirB6 2.8e-33 7623 H4301R3_000000001191 19726 21367 f KOfam K01953 asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 1.6e-65 7611 H4301R3_000000001191 8990 9668 f KOfam K03203 type IV secretion system protein VirB8 2.9e-71 7610 H4301R3_000000001191 8626 8974 f KOfam K03202 type IV secretion system protein VirB7 3.3e-07 7630 H4301R3_000000001191 27501 28335 r KOfam K07492 putative transposase 2.4e-99 7628 H4301R3_000000001191 25044 25803 f KOfam K22438 trans-aconitate 3-methyltransferase [EC:2.1.1.145] 1.3e-44 7602 H4301R3_000000001191 1280 1877 f KOfam K03194 type IV secretion system protein VirB1 7.9e-53 7613 H4301R3_000000001191 10681 11944 f KOfam K03195 type IV secretion system protein VirB10 3.1e-95 7604 H4301R3_000000001191 3485 3803 f KOfam K03197 type IV secretion system protein VirB2 3.4e-25 7614 H4301R3_000000001191 11947 12964 f KOfam K03196 type IV secretion system protein VirB11 [EC:7.4.2.8] 2.6e-124 7600 H4301R3_000000001191 136 940 f KOfam K03194 type IV secretion system protein VirB1 4.6e-15 7617 H4301R3_000000001191 15709 16540 f KOfam K00477 phytanoyl-CoA hydroxylase [EC:1.14.11.18] 1.3e-40 7600 H4301R3_000000001191 136 940 f EGGNOG_BACT 1112214.AHIS01000142_gene3392 lytic transglycosylase activity 9.2e-117 7600 H4301R3_000000001191 136 940 f EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3392 M 9.2e-117 7602 H4301R3_000000001191 1280 1877 f EGGNOG_BACT 1096930.L284_07055 Transglycosylase SLT domain 1.59e-94 7602 H4301R3_000000001191 1280 1877 f EGGNOG_COG_CATEGORY 1096930.L284_07055 M 1.59e-94 7603 H4301R3_000000001191 1873 3478 f EGGNOG_BACT 1096930.L284_07050 relaxase mobilization nuclease domain protein 4.69e-90 7603 H4301R3_000000001191 1873 3478 f EGGNOG_COG_CATEGORY 1096930.L284_07050 U 4.69e-90 7604 H4301R3_000000001191 3485 3803 f EGGNOG_BACT 1096930.L284_07045 TrbC/VIRB2 family 5.01e-49 7604 H4301R3_000000001191 3485 3803 f EGGNOG_COG_CATEGORY 1096930.L284_07045 S 5.01e-49 7605 H4301R3_000000001191 3809 4145 f EGGNOG_BACT 1096930.L284_07040 Type IV secretory pathway, VirB3-like protein 4.3e-68 7605 H4301R3_000000001191 3809 4145 f EGGNOG_COG_CATEGORY 1096930.L284_07040 U 4.3e-68 7606 H4301R3_000000001191 4137 6504 f EGGNOG_BACT 1096930.L284_07035 type IV secretion system 0 7606 H4301R3_000000001191 4137 6504 f EGGNOG_COG_CATEGORY 1096930.L284_07035 U 0 7607 H4301R3_000000001191 6503 7229 f EGGNOG_BACT 1096930.L284_07030 Type IV secretion system proteins 2.85e-101 7607 H4301R3_000000001191 6503 7229 f EGGNOG_COG_CATEGORY 1096930.L284_07030 S 2.85e-101 7609 H4301R3_000000001191 7502 8555 f EGGNOG_BACT 1096930.L284_07020 TrbL/VirB6 plasmid conjugal transfer protein 9.59e-198 7609 H4301R3_000000001191 7502 8555 f EGGNOG_COG_CATEGORY 1096930.L284_07020 U 9.59e-198 7611 H4301R3_000000001191 8990 9668 f EGGNOG_BACT 1096930.L284_07015 Conjugal transfer protein TraJ 6.28e-130 7611 H4301R3_000000001191 8990 9668 f EGGNOG_COG_CATEGORY 1096930.L284_07015 U 6.28e-130 7612 H4301R3_000000001191 9669 10680 f EGGNOG_BACT 1112214.AHIS01000142_gene3383 virB9 :: Conjugal transfer protein trbG 2.77e-188 7612 H4301R3_000000001191 9669 10680 f EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3383 U 2.77e-188 7613 H4301R3_000000001191 10681 11944 f EGGNOG_BACT 1112214.AHIS01000142_gene3382 Bacterial conjugation TrbI-like protein 2.48e-192 7613 H4301R3_000000001191 10681 11944 f EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3382 U 2.48e-192 7614 H4301R3_000000001191 11947 12964 f EGGNOG_BACT 1112214.AHIS01000142_gene3381 Type IV secretion protein VirB11 3.18e-221 7614 H4301R3_000000001191 11947 12964 f EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3381 NU 3.18e-221 7615 H4301R3_000000001191 12978 14922 f EGGNOG_BACT 1112214.AHIS01000142_gene3380 TraM recognition site of TraD and TraG 2.26e-306 7615 H4301R3_000000001191 12978 14922 f EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3380 U 2.26e-306 7617 H4301R3_000000001191 15709 16540 f EGGNOG_BACT 1120950.KB892758_gene6313 Phytanoyl-CoA dioxygenase (PhyH) 2.67e-56 7617 H4301R3_000000001191 15709 16540 f EGGNOG_COG_CATEGORY 1120950.KB892758_gene6313 Q 2.67e-56 7622 H4301R3_000000001191 18651 19695 f EGGNOG_BACT 953739.SVEN_6208 beta-ketoacyl-acyl-carrier-protein synthase III activity 5.41e-15 7622 H4301R3_000000001191 18651 19695 f EGGNOG_COG_CATEGORY 953739.SVEN_6208 I 5.41e-15 7623 H4301R3_000000001191 19726 21367 f EGGNOG_BACT 1463920.JOGB01000090_gene133 Asparagine synthase 1.02e-57 7623 H4301R3_000000001191 19726 21367 f EGGNOG_COG_CATEGORY 1463920.JOGB01000090_gene133 E 1.02e-57 7624 H4301R3_000000001191 21350 22883 f EGGNOG_BACT 1246474.ANBE01000014_gene2911 PFAM AMP-dependent synthetase and ligase 3.27e-51 7624 H4301R3_000000001191 21350 22883 f EGGNOG_COG_CATEGORY 1246474.ANBE01000014_gene2911 IQ 3.27e-51 7625 H4301R3_000000001191 22869 23583 f EGGNOG_BACT 83219.PM02_15200 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin 3.03e-15 7625 H4301R3_000000001191 22869 23583 f EGGNOG_COG_CATEGORY 83219.PM02_15200 Q 3.03e-15 7626 H4301R3_000000001191 23579 24146 f EGGNOG_BACT 89187.ISM_12205 palmitoyl-(protein) hydrolase activity 1.45e-07 7626 H4301R3_000000001191 23579 24146 f EGGNOG_COG_CATEGORY 89187.ISM_12205 S 1.45e-07 7627 H4301R3_000000001191 24142 25033 f EGGNOG_BACT 68260.JOAY01000014_gene2705 Taurine catabolism dioxygenase TauD, TfdA family 1.18e-36 7627 H4301R3_000000001191 24142 25033 f EGGNOG_COG_CATEGORY 68260.JOAY01000014_gene2705 Q 1.18e-36 7628 H4301R3_000000001191 25044 25803 f EGGNOG_BACT 1247963.JPHU01000006_gene160 Methyltransferase domain 3.08e-66 7628 H4301R3_000000001191 25044 25803 f EGGNOG_COG_CATEGORY 1247963.JPHU01000006_gene160 Q 3.08e-66 7629 H4301R3_000000001191 25799 27482 f EGGNOG_BACT 1463920.JOGB01000090_gene131 HMGL-like 3.01e-143 7629 H4301R3_000000001191 25799 27482 f EGGNOG_COG_CATEGORY 1463920.JOGB01000090_gene131 E 3.01e-143 7630 H4301R3_000000001191 27501 28335 r EGGNOG_BACT 1346791.M529_22425 Transposase 9.38e-187 7630 H4301R3_000000001191 27501 28335 r EGGNOG_COG_CATEGORY 1346791.M529_22425 L 9.38e-187 Plasmid-4 (H5101R1_000000000624) Gene ID MGE start end orientation annotation 4778 H5101R1_000000000624 177 1011 f COG14_FUNCTION COG3293 Transposase 2.6e-137 4779 H5101R1_000000000624 1030 2713 r COG14_FUNCTION COG0119 Isopropylmalate/homocitrate/citramalate synthases 6.4e-103 4780 H5101R1_000000000624 2709 3468 r COG14_FUNCTION COG2226 Ubiquinone/menaquinone biosynthesis C-methylase UbiE 1.2e-53 4783 H5101R1_000000000624 4929 5643 r COG14_FUNCTION COG5285 Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family 4.6e-10 4784 H5101R1_000000000624 5629 7162 r COG14_FUNCTION COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II 1.1e-29 4785 H5101R1_000000000624 7145 8786 r COG14_FUNCTION COG0367 Asparagine synthetase B (glutamine-hydrolyzing) 6.4e-31 4791 H5101R1_000000000624 11972 12803 r COG14_FUNCTION COG5285 Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family 2.9e-40 4793 H5101R1_000000000624 13590 15534 r COG14_FUNCTION COG3505 Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase 1.1e-212 4794 H5101R1_000000000624 15548 16565 r COG14_FUNCTION COG0630 Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase 2e-160 4795 H5101R1_000000000624 16568 17831 r COG14_FUNCTION COG2948 Type IV secretory pathway, VirB10 components 3.3e-144 4796 H5101R1_000000000624 17832 18843 r COG14_FUNCTION COG3504 Type IV secretory pathway, VirB9 components 2.4e-121 4797 H5101R1_000000000624 18844 19522 r COG14_FUNCTION COG3736 Type IV secretory pathway, component VirB8 1e-88 4799 H5101R1_000000000624 19957 21010 r COG14_FUNCTION COG3704 Type IV secretory pathway, VirB6 components 7.5e-118 4802 H5101R1_000000000624 22008 24375 r COG14_FUNCTION COG3451 Type IV secretory pathway, VirB4 component 0 4803 H5101R1_000000000624 24367 24703 r COG14_FUNCTION COG3702 Type IV secretory pathway, VirB3 components 8.9e-49 4805 H5101R1_000000000624 25034 26639 r COG14_FUNCTION COG3843 Type IV secretory pathway, VirD2 components (relaxase) 4.9e-20 4806 H5101R1_000000000624 26635 27232 r COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 1.5e-59 4808 H5101R1_000000000624 27572 28376 r COG14_FUNCTION COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 7.4e-25 4809 H5101R1_000000000624 28616 29264 f COG14_FUNCTION COG1961 Site-specific DNA recombinase related to the DNA invertase Pin 8.1e-06 4811 H5101R1_000000000624 29544 29793 r COG14_FUNCTION COG1396 Transcriptional regulator, contains XRE-family HTH domain 5.6e-08 4813 H5101R1_000000000624 30450 31311 f COG14_FUNCTION COG5534 Plasmid replication initiator protein 1.1e-66 4815 H5101R1_000000000624 33086 33950 f COG14_FUNCTION COG4643 Uncharacterized domain associated with phage/plasmid primase 8.8e-40 4817 H5101R1_000000000624 34874 36740 r COG14_FUNCTION COG3344 Retron-type reverse transcriptase 3.9e-312 4782 H5101R1_000000000624 4366 4933 r Pfam PF02230.16 Phospholipase/Carboxylesterase 4.3e-10 4782 H5101R1_000000000624 4366 4933 r Pfam PF12697.7 Alpha/beta hydrolase family 3.5e-08 4786 H5101R1_000000000624 8817 9861 r Pfam PF08545.10 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 3.6e-08 4786 H5101R1_000000000624 8817 9861 r Pfam PF08541.10 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 3.3e-08 4784 H5101R1_000000000624 5629 7162 r Pfam PF00501.28 AMP-binding enzyme 2.2e-55 4784 H5101R1_000000000624 5629 7162 r Pfam PF13193.6 AMP-binding enzyme C-terminal domain 1.5e-07 4785 H5101R1_000000000624 7145 8786 r Pfam PF00733.21 Asparagine synthase 5.2e-30 4802 H5101R1_000000000624 22008 24375 r Pfam PF03135.14 CagE, TrbE, VirB family, component of type IV transporter system 2.5e-43 4796 H5101R1_000000000624 17832 18843 r Pfam PF03524.15 Conjugal transfer protein 2.8e-60 4778 H5101R1_000000000624 177 1011 f Pfam PF01609.21 Transposase DDE domain 2.8e-30 4778 H5101R1_000000000624 177 1011 f Pfam PF13586.6 Transposase DDE domain 1e-15 4782 H5101R1_000000000624 4366 4933 r Pfam PF01738.18 Dienelactone hydrolase family 2.8e-06 4778 H5101R1_000000000624 177 1011 f Pfam PF13340.6 Putative transposase of IS4/5 family (DUF4096) 2.3e-26 4779 H5101R1_000000000624 1030 2713 r Pfam PF00682.19 HMGL-like 2.3e-61 4811 H5101R1_000000000624 29544 29793 r Pfam PF12844.7 Helix-turn-helix domain 1.4e-12 4809 H5101R1_000000000624 28616 29264 f Pfam PF13384.6 Homeodomain-like domain 1.3e-07 4811 H5101R1_000000000624 29544 29793 r Pfam PF13413.6 Helix-turn-helix domain 8.1e-08 4811 H5101R1_000000000624 29544 29793 r Pfam PF01381.22 Helix-turn-helix 2.6e-17 4810 H5101R1_000000000624 29129 29393 r Pfam PF01381.22 Helix-turn-helix 8.3e-08 4811 H5101R1_000000000624 29544 29793 r Pfam PF13560.6 Helix-turn-helix domain 2.5e-15 4810 H5101R1_000000000624 29129 29393 r Pfam PF13560.6 Helix-turn-helix domain 1.3e-08 4809 H5101R1_000000000624 28616 29264 f Pfam PF02796.15 Helix-turn-helix domain of resolvase 1.6e-08 4817 H5101R1_000000000624 34874 36740 r Pfam PF01348.21 Type II intron maturase 5.1e-08 4805 H5101R1_000000000624 25034 26639 r Pfam PF18821.1 Large polyvalent protein-associated domain 7 2.6e-21 4780 H5101R1_000000000624 2709 3468 r Pfam PF08241.12 Methyltransferase domain 7.9e-17 4780 H5101R1_000000000624 2709 3468 r Pfam PF13649.6 Methyltransferase domain 4e-13 4791 H5101R1_000000000624 11972 12803 r Pfam PF05721.13 Phytanoyl-CoA dioxygenase (PhyH) 4.1e-30 4783 H5101R1_000000000624 4929 5643 r Pfam PF05721.13 Phytanoyl-CoA dioxygenase (PhyH) 1.2e-26 4813 H5101R1_000000000624 30450 31311 f Pfam PF01051.21 Initiator Replication protein 3.1e-08 4813 H5101R1_000000000624 30450 31311 f Pfam PF10134.9 Replication initiator protein A 1.2e-56 4817 H5101R1_000000000624 34874 36740 r Pfam PF00078.27 Reverse transcriptase (RNA-dependent DNA polymerase) 2.3e-37 4806 H5101R1_000000000624 26635 27232 r Pfam PF01464.20 Transglycosylase SLT domain 2.8e-16 4794 H5101R1_000000000624 15548 16565 r Pfam PF00437.20 Type II/IV secretion system protein 7.2e-63 4801 H5101R1_000000000624 21283 22009 r Pfam PF07996.11 Type IV secretion system proteins 7.4e-45 4793 H5101R1_000000000624 13590 15534 r Pfam PF02534.14 Type IV secretory system Conjugative DNA transfer 4.4e-93 4781 H5101R1_000000000624 3479 4370 r Pfam PF02668.16 Taurine catabolism dioxygenase TauD, TfdA family 1.4e-18 4815 H5101R1_000000000624 33086 33950 f Pfam PF13362.6 Toprim domain 2.8e-11 4793 H5101R1_000000000624 13590 15534 r Pfam PF12696.7 TraM recognition site of TraD and TraG 2.4e-27 4806 H5101R1_000000000624 26635 27232 r Pfam PF06871.11 TraH_2 4.8e-08 4804 H5101R1_000000000624 24709 25027 r Pfam PF04956.13 TrbC/VIRB2 family 4.2e-19 4795 H5101R1_000000000624 16568 17831 r Pfam PF03743.14 Bacterial conjugation TrbI-like protein 1.6e-50 4799 H5101R1_000000000624 19957 21010 r Pfam PF04610.14 TrbL/VirB6 plasmid conjugal transfer protein 4.4e-29 4793 H5101R1_000000000624 13590 15534 r Pfam PF10412.9 Type IV secretion-system coupling protein DNA-binding domain 3.5e-21 4803 H5101R1_000000000624 24367 24703 r Pfam PF05101.13 Type IV secretory pathway, VirB3-like protein 2.4e-22 4797 H5101R1_000000000624 18844 19522 r Pfam PF04335.13 VirB8 protein 1.6e-58 4803 H5101R1_000000000624 24367 24703 r KOfam K03198 type IV secretion system protein VirB3 2.1e-30 4793 H5101R1_000000000624 13590 15534 r KOfam K03205 type IV secretion system protein VirD4 [EC:7.4.2.8] 2.1e-145 4796 H5101R1_000000000624 17832 18843 r KOfam K03204 type IV secretion system protein VirB9 4.7e-100 4802 H5101R1_000000000624 22008 24375 r KOfam K03199 type IV secretion system protein VirB4 [EC:7.4.2.8] 0 4801 H5101R1_000000000624 21283 22009 r KOfam K03200 type IV secretion system protein VirB5 4.5e-35 4799 H5101R1_000000000624 19957 21010 r KOfam K03201 type IV secretion system protein VirB6 1.4e-33 4785 H5101R1_000000000624 7145 8786 r KOfam K01953 asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 8.2e-66 4797 H5101R1_000000000624 18844 19522 r KOfam K03203 type IV secretion system protein VirB8 1.5e-71 4798 H5101R1_000000000624 19538 19886 r KOfam K03202 type IV secretion system protein VirB7 1.7e-07 4817 H5101R1_000000000624 34874 36740 r KOfam K00986 RNA-directed DNA polymerase [EC:2.7.7.49] 2.4e-84 4778 H5101R1_000000000624 177 1011 f KOfam K07492 putative transposase 1.2e-99 4780 H5101R1_000000000624 2709 3468 r KOfam K22438 trans-aconitate 3-methyltransferase [EC:2.1.1.145] 6.9e-45 4806 H5101R1_000000000624 26635 27232 r KOfam K03194 type IV secretion system protein VirB1 4.1e-53 4795 H5101R1_000000000624 16568 17831 r KOfam K03195 type IV secretion system protein VirB10 1.6e-95 4804 H5101R1_000000000624 24709 25027 r KOfam K03197 type IV secretion system protein VirB2 1.8e-25 4794 H5101R1_000000000624 15548 16565 r KOfam K03196 type IV secretion system protein VirB11 [EC:7.4.2.8] 1.3e-124 4791 H5101R1_000000000624 11972 12803 r KOfam K00477 phytanoyl-CoA hydroxylase [EC:1.14.11.18] 6.9e-41 4808 H5101R1_000000000624 27572 28376 r KOfam K03194 type IV secretion system protein VirB1 2.4e-15 4811 H5101R1_000000000624 29544 29793 r KOfam K07729 putative transcriptional regulator 4.4e-14 4778 H5101R1_000000000624 177 1011 f EGGNOG_BACT 1346791.M529_22425 Transposase 9.38e-187 4778 H5101R1_000000000624 177 1011 f EGGNOG_COG_CATEGORY 1346791.M529_22425 L 9.38e-187 4779 H5101R1_000000000624 1030 2713 r EGGNOG_BACT 1463920.JOGB01000090_gene131 HMGL-like 3.01e-143 4779 H5101R1_000000000624 1030 2713 r EGGNOG_COG_CATEGORY 1463920.JOGB01000090_gene131 E 3.01e-143 4780 H5101R1_000000000624 2709 3468 r EGGNOG_BACT 1247963.JPHU01000006_gene160 Methyltransferase domain 3.08e-66 4780 H5101R1_000000000624 2709 3468 r EGGNOG_COG_CATEGORY 1247963.JPHU01000006_gene160 Q 3.08e-66 4781 H5101R1_000000000624 3479 4370 r EGGNOG_BACT 68260.JOAY01000014_gene2705 Taurine catabolism dioxygenase TauD, TfdA family 1.18e-36 4781 H5101R1_000000000624 3479 4370 r EGGNOG_COG_CATEGORY 68260.JOAY01000014_gene2705 Q 1.18e-36 4782 H5101R1_000000000624 4366 4933 r EGGNOG_BACT 89187.ISM_12205 palmitoyl-(protein) hydrolase activity 1.45e-07 4782 H5101R1_000000000624 4366 4933 r EGGNOG_COG_CATEGORY 89187.ISM_12205 S 1.45e-07 4783 H5101R1_000000000624 4929 5643 r EGGNOG_BACT 83219.PM02_15200 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin 3.03e-15 4783 H5101R1_000000000624 4929 5643 r EGGNOG_COG_CATEGORY 83219.PM02_15200 Q 3.03e-15 4784 H5101R1_000000000624 5629 7162 r EGGNOG_BACT 1246474.ANBE01000014_gene2911 PFAM AMP-dependent synthetase and ligase 3.27e-51 4784 H5101R1_000000000624 5629 7162 r EGGNOG_COG_CATEGORY 1246474.ANBE01000014_gene2911 IQ 3.27e-51 4785 H5101R1_000000000624 7145 8786 r EGGNOG_BACT 1463920.JOGB01000090_gene133 Asparagine synthase 1.02e-57 4785 H5101R1_000000000624 7145 8786 r EGGNOG_COG_CATEGORY 1463920.JOGB01000090_gene133 E 1.02e-57 4786 H5101R1_000000000624 8817 9861 r EGGNOG_BACT 953739.SVEN_6208 beta-ketoacyl-acyl-carrier-protein synthase III activity 5.41e-15 4786 H5101R1_000000000624 8817 9861 r EGGNOG_COG_CATEGORY 953739.SVEN_6208 I 5.41e-15 4791 H5101R1_000000000624 11972 12803 r EGGNOG_BACT 1120950.KB892758_gene6313 Phytanoyl-CoA dioxygenase (PhyH) 2.67e-56 4791 H5101R1_000000000624 11972 12803 r EGGNOG_COG_CATEGORY 1120950.KB892758_gene6313 Q 2.67e-56 4793 H5101R1_000000000624 13590 15534 r EGGNOG_BACT 1112214.AHIS01000142_gene3380 TraM recognition site of TraD and TraG 2.26e-306 4793 H5101R1_000000000624 13590 15534 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3380 U 2.26e-306 4794 H5101R1_000000000624 15548 16565 r EGGNOG_BACT 1112214.AHIS01000142_gene3381 Type IV secretion protein VirB11 3.18e-221 4794 H5101R1_000000000624 15548 16565 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3381 NU 3.18e-221 4795 H5101R1_000000000624 16568 17831 r EGGNOG_BACT 1112214.AHIS01000142_gene3382 Bacterial conjugation TrbI-like protein 2.48e-192 4795 H5101R1_000000000624 16568 17831 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3382 U 2.48e-192 4796 H5101R1_000000000624 17832 18843 r EGGNOG_BACT 1112214.AHIS01000142_gene3383 virB9 :: Conjugal transfer protein trbG 2.77e-188 4796 H5101R1_000000000624 17832 18843 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3383 U 2.77e-188 4797 H5101R1_000000000624 18844 19522 r EGGNOG_BACT 1096930.L284_07015 Conjugal transfer protein TraJ 6.28e-130 4797 H5101R1_000000000624 18844 19522 r EGGNOG_COG_CATEGORY 1096930.L284_07015 U 6.28e-130 4799 H5101R1_000000000624 19957 21010 r EGGNOG_BACT 1096930.L284_07020 TrbL/VirB6 plasmid conjugal transfer protein 9.59e-198 4799 H5101R1_000000000624 19957 21010 r EGGNOG_COG_CATEGORY 1096930.L284_07020 U 9.59e-198 4801 H5101R1_000000000624 21283 22009 r EGGNOG_BACT 1096930.L284_07030 Type IV secretion system proteins 2.85e-101 4801 H5101R1_000000000624 21283 22009 r EGGNOG_COG_CATEGORY 1096930.L284_07030 S 2.85e-101 4802 H5101R1_000000000624 22008 24375 r EGGNOG_BACT 1096930.L284_07035 type IV secretion system 0 4802 H5101R1_000000000624 22008 24375 r EGGNOG_COG_CATEGORY 1096930.L284_07035 U 0 4803 H5101R1_000000000624 24367 24703 r EGGNOG_BACT 1096930.L284_07040 Type IV secretory pathway, VirB3-like protein 4.3e-68 4803 H5101R1_000000000624 24367 24703 r EGGNOG_COG_CATEGORY 1096930.L284_07040 U 4.3e-68 4804 H5101R1_000000000624 24709 25027 r EGGNOG_BACT 1096930.L284_07045 TrbC/VIRB2 family 5.01e-49 4804 H5101R1_000000000624 24709 25027 r EGGNOG_COG_CATEGORY 1096930.L284_07045 S 5.01e-49 4805 H5101R1_000000000624 25034 26639 r EGGNOG_BACT 1096930.L284_07050 relaxase mobilization nuclease domain protein 4.69e-90 4805 H5101R1_000000000624 25034 26639 r EGGNOG_COG_CATEGORY 1096930.L284_07050 U 4.69e-90 4806 H5101R1_000000000624 26635 27232 r EGGNOG_BACT 1096930.L284_07055 Transglycosylase SLT domain 1.59e-94 4806 H5101R1_000000000624 26635 27232 r EGGNOG_COG_CATEGORY 1096930.L284_07055 M 1.59e-94 4808 H5101R1_000000000624 27572 28376 r EGGNOG_BACT 1112214.AHIS01000142_gene3392 lytic transglycosylase activity 9.2e-117 4808 H5101R1_000000000624 27572 28376 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3392 M 9.2e-117 4809 H5101R1_000000000624 28616 29264 f EGGNOG_BACT 1029824.AFID01000016_gene1155 Helix-turn-helix domain 2.1e-07 4809 H5101R1_000000000624 28616 29264 f EGGNOG_COG_CATEGORY 1029824.AFID01000016_gene1155 L 2.1e-07 4810 H5101R1_000000000624 29129 29393 r EGGNOG_BACT 1120983.KB894570_gene1760 MA20_09785 :: Helix-turn-helix XRE-family like proteins 0.000823 4810 H5101R1_000000000624 29129 29393 r EGGNOG_COG_CATEGORY 1120983.KB894570_gene1760 K 0.000823 4811 H5101R1_000000000624 29544 29793 r EGGNOG_BACT 1096930.L284_07070 sequence-specific DNA binding 3.19e-38 4811 H5101R1_000000000624 29544 29793 r EGGNOG_COG_CATEGORY 1096930.L284_07070 K 3.19e-38 4813 H5101R1_000000000624 30450 31311 f EGGNOG_BACT 1096930.L284_07085 Replication initiator protein A 4.5e-167 4813 H5101R1_000000000624 30450 31311 f EGGNOG_COG_CATEGORY 1096930.L284_07085 L 4.5e-167 4814 H5101R1_000000000624 31758 32784 f EGGNOG_BACT 1122612.AUBA01000021_gene2602 repA :: purine nucleotide biosynthetic process 2.56e-66 4814 H5101R1_000000000624 31758 32784 f EGGNOG_COG_CATEGORY 1122612.AUBA01000021_gene2602 K 2.56e-66 4815 H5101R1_000000000624 33086 33950 f EGGNOG_BACT 1096930.L284_07100 Toprim domain 1.27e-146 4815 H5101R1_000000000624 33086 33950 f EGGNOG_COG_CATEGORY 1096930.L284_07100 S 1.27e-146 4817 H5101R1_000000000624 34874 36740 r EGGNOG_BACT 1114964.L485_02535 Type II intron maturase 0 4817 H5101R1_000000000624 34874 36740 r EGGNOG_COG_CATEGORY 1114964.L485_02535 L 0 Plasmid-5 (H4101R2_000000009191) Gene ID MGE start end orientation annotation 6797 H4101R2_000000009191 601 1249 f COG14_FUNCTION COG1961 Site-specific DNA recombinase related to the DNA invertase Pin 8.1e-06 6799 H4101R2_000000009191 1529 1778 r COG14_FUNCTION COG1396 Transcriptional regulator, contains XRE-family HTH domain 5.6e-08 6801 H4101R2_000000009191 2435 3296 f COG14_FUNCTION COG5534 Plasmid replication initiator protein 1.1e-66 6803 H4101R2_000000009191 5071 5935 f COG14_FUNCTION COG4643 Uncharacterized domain associated with phage/plasmid primase 8.8e-40 6799 H4101R2_000000009191 1529 1778 r Pfam PF12844.7 Helix-turn-helix domain 2.6e-12 6797 H4101R2_000000009191 601 1249 f Pfam PF13384.6 Homeodomain-like domain 2.4e-07 6799 H4101R2_000000009191 1529 1778 r Pfam PF13413.6 Helix-turn-helix domain 1.5e-07 6799 H4101R2_000000009191 1529 1778 r Pfam PF01381.22 Helix-turn-helix 4.8e-17 6798 H4101R2_000000009191 1114 1378 r Pfam PF01381.22 Helix-turn-helix 1.5e-07 6799 H4101R2_000000009191 1529 1778 r Pfam PF13560.6 Helix-turn-helix domain 4.5e-15 6798 H4101R2_000000009191 1114 1378 r Pfam PF13560.6 Helix-turn-helix domain 2.4e-08 6797 H4101R2_000000009191 601 1249 f Pfam PF02796.15 Helix-turn-helix domain of resolvase 2.9e-08 6801 H4101R2_000000009191 2435 3296 f Pfam PF01051.21 Initiator Replication protein 5.7e-08 6801 H4101R2_000000009191 2435 3296 f Pfam PF10134.9 Replication initiator protein A 2.3e-56 6803 H4101R2_000000009191 5071 5935 f Pfam PF13362.6 Toprim domain 5.1e-11 6796 H4101R2_000000009191 1 361 r KOfam K03194 type IV secretion system protein VirB1 2.3e-14 6799 H4101R2_000000009191 1529 1778 r KOfam K07729 putative transcriptional regulator 8.1e-14 6796 H4101R2_000000009191 1 361 r EGGNOG_BACT 1112214.AHIS01000142_gene3392 lytic transglycosylase activity 5.21e-35 6796 H4101R2_000000009191 1 361 r EGGNOG_COG_CATEGORY 1112214.AHIS01000142_gene3392 M 5.21e-35 6797 H4101R2_000000009191 601 1249 f EGGNOG_BACT 1029824.AFID01000016_gene1155 Helix-turn-helix domain 2.1e-07 6797 H4101R2_000000009191 601 1249 f EGGNOG_COG_CATEGORY 1029824.AFID01000016_gene1155 L 2.1e-07 6798 H4101R2_000000009191 1114 1378 r EGGNOG_BACT 1120983.KB894570_gene1760 MA20_09785 :: Helix-turn-helix XRE-family like proteins 0.000823 6798 H4101R2_000000009191 1114 1378 r EGGNOG_COG_CATEGORY 1120983.KB894570_gene1760 K 0.000823 6799 H4101R2_000000009191 1529 1778 r EGGNOG_BACT 1096930.L284_07070 sequence-specific DNA binding 3.19e-38 6799 H4101R2_000000009191 1529 1778 r EGGNOG_COG_CATEGORY 1096930.L284_07070 K 3.19e-38 6801 H4101R2_000000009191 2435 3296 f EGGNOG_BACT 1096930.L284_07085 Replication initiator protein A 4.5e-167 6801 H4101R2_000000009191 2435 3296 f EGGNOG_COG_CATEGORY 1096930.L284_07085 L 4.5e-167 6802 H4101R2_000000009191 3743 4769 f EGGNOG_BACT 1122612.AUBA01000021_gene2602 repA :: purine nucleotide biosynthetic process 2.56e-66 6802 H4101R2_000000009191 3743 4769 f EGGNOG_COG_CATEGORY 1122612.AUBA01000021_gene2602 K 2.56e-66 6803 H4101R2_000000009191 5071 5935 f EGGNOG_BACT 1096930.L284_07100 Toprim domain 1.27e-146 6803 H4101R2_000000009191 5071 5935 f EGGNOG_COG_CATEGORY 1096930.L284_07100 S 1.27e-146 Plasmid-6 (H1401R2_000000026216) Gene ID MGE start end orientation annotation 8057 H1401R2_000000026216 1 667 r EGGNOG_BACT 1096930.L284_07085 Replication initiator protein A 7.84e-135 8057 H1401R2_000000026216 1 667 r EGGNOG_COG_CATEGORY 1096930.L284_07085 L 7.84e-135 8059 H1401R2_000000026216 1324 1573 f EGGNOG_BACT 1096930.L284_07070 sequence-specific DNA binding 3.19e-38 8059 H1401R2_000000026216 1324 1573 f EGGNOG_COG_CATEGORY 1096930.L284_07070 K 3.19e-38 8060 H1401R2_000000026216 1853 2159 r EGGNOG_BACT 1285583.CCASEI_00535 Site-specific recombinases, DNA invertase Pin homologs 2.91e-06 8060 H1401R2_000000026216 1853 2159 r EGGNOG_COG_CATEGORY 1285583.CCASEI_00535 L 2.91e-06 8057 H1401R2_000000026216 1 667 r COG14_FUNCTION COG5534 Plasmid replication initiator protein 4.2e-58 8059 H1401R2_000000026216 1324 1573 f COG14_FUNCTION COG1396 Transcriptional regulator, contains XRE-family HTH domain 5.6e-08 8059 H1401R2_000000026216 1324 1573 f Pfam PF12844.7 Helix-turn-helix domain 2.2e-12 8060 H1401R2_000000026216 1853 2159 r Pfam PF13384.6 Homeodomain-like domain 1.2e-07 8059 H1401R2_000000026216 1324 1573 f Pfam PF13413.6 Helix-turn-helix domain 1.3e-07 8059 H1401R2_000000026216 1324 1573 f Pfam PF01381.22 Helix-turn-helix 4.2e-17 8059 H1401R2_000000026216 1324 1573 f Pfam PF13560.6 Helix-turn-helix domain 3.9e-15 8060 H1401R2_000000026216 1853 2159 r Pfam PF02796.15 Helix-turn-helix domain of resolvase 1e-08 8057 H1401R2_000000026216 1 667 r Pfam PF01051.21 Initiator Replication protein 1.2e-07 8057 H1401R2_000000026216 1 667 r Pfam PF10134.9 Replication initiator protein A 2.4e-49 8059 H1401R2_000000026216 1324 1573 f KOfam K07729 putative transcriptional regulator 7.1e-14 Phage-1 (H5101R2_000000018434) Gene ID MGE start end orientation annotation 4860 H5101R2_000000018434 0 222 r COG14_FUNCTION COG1396 Transcriptional regulator, contains XRE-family HTH domain 5.6e-07 4862 H5101R2_000000018434 879 1740 f COG14_FUNCTION COG5534 Plasmid replication initiator protein 1.1e-66 4864 H5101R2_000000018434 3515 4379 f COG14_FUNCTION COG4643 Uncharacterized domain associated with phage/plasmid primase 8.8e-40 4860 H5101R2_000000018434 0 222 r Pfam PF12844.7 Helix-turn-helix domain 1.4e-12 4860 H5101R2_000000018434 0 222 r Pfam PF13413.6 Helix-turn-helix domain 8.5e-08 4860 H5101R2_000000018434 0 222 r Pfam PF01381.22 Helix-turn-helix 2e-17 4860 H5101R2_000000018434 0 222 r Pfam PF13560.6 Helix-turn-helix domain 2.3e-15 4862 H5101R2_000000018434 879 1740 f Pfam PF01051.21 Initiator Replication protein 3.1e-08 4862 H5101R2_000000018434 879 1740 f Pfam PF10134.9 Replication initiator protein A 1.2e-56 4864 H5101R2_000000018434 3515 4379 f Pfam PF13362.6 Toprim domain 2.8e-11 4860 H5101R2_000000018434 0 222 r KOfam K07729 putative transcriptional regulator 9.9e-14 4860 H5101R2_000000018434 0 222 r EGGNOG_BACT 1096930.L284_07070 sequence-specific DNA binding 1.22e-33 4860 H5101R2_000000018434 0 222 r EGGNOG_COG_CATEGORY 1096930.L284_07070 K 1.22e-33 4862 H5101R2_000000018434 879 1740 f EGGNOG_BACT 1096930.L284_07085 Replication initiator protein A 4.5e-167 4862 H5101R2_000000018434 879 1740 f EGGNOG_COG_CATEGORY 1096930.L284_07085 L 4.5e-167 4863 H5101R2_000000018434 2187 3213 f EGGNOG_BACT 1122612.AUBA01000021_gene2602 repA :: purine nucleotide biosynthetic process 2.56e-66 4863 H5101R2_000000018434 2187 3213 f EGGNOG_COG_CATEGORY 1122612.AUBA01000021_gene2602 K 2.56e-66 4864 H5101R2_000000018434 3515 4379 f EGGNOG_BACT 1096930.L284_07100 Toprim domain 1.27e-146 4864 H5101R2_000000018434 3515 4379 f EGGNOG_COG_CATEGORY 1096930.L284_07100 S 1.27e-146